                         б

<110>  ѧ

<120>  һҸβ浰ͻ弰ڿҸβеӦ

<160>  31

<170>  SIPOSequenceListing 1.0

<210>  1
<211>  226
<212>  PRT
<213>  AS(Hepatitis B virus)

<400>  1
Met Glu Asn Ile Thr Ser Gly Phe Leu Gly Pro Leu Leu Val Leu Gln 
1               5                   10                  15      
Ala Gly Phe Phe Leu Leu Thr Arg Ile Leu Thr Ile Pro Gln Ser Leu 
            20                  25                  30          
Asp Ser Trp Trp Thr Ser Leu Asn Phe Leu Gly Gly Ser Pro Val Cys 
        35                  40                  45              
Leu Gly Gln Asn Ser Gln Ser Pro Thr Ser Asn His Ser Pro Thr Ser 
    50                  55                  60                  
Cys Pro Pro Ile Cys Pro Gly Tyr Arg Trp Met Cys Leu Arg Arg Phe 
65                  70                  75                  80  
Ile Ile Phe Leu Phe Ile Leu Leu Leu Cys Leu Ile Phe Leu Leu Val 
                85                  90                  95      
Leu Leu Asp Tyr Gln Gly Met Leu Pro Val Cys Pro Leu Ile Pro Gly 
            100                 105                 110         
Ser Thr Thr Thr Ser Thr Gly Pro Cys Lys Thr Cys Thr Thr Pro Ala 
        115                 120                 125             
Gln Gly Asn Ser Met Phe Pro Ser Cys Cys Cys Thr Lys Pro Thr Asp 
    130                 135                 140                 
Gly Asn Cys Thr Cys Ile Pro Ile Pro Ser Ser Trp Ala Phe Ala Lys 
145                 150                 155                 160 
Tyr Leu Trp Glu Trp Ala Ser Val Arg Phe Ser Trp Leu Ser Leu Leu 
                165                 170                 175     
Val Pro Phe Val Gln Trp Phe Val Gly Leu Ser Pro Thr Val Trp Leu 
            180                 185                 190         
Ser Ala Ile Trp Met Met Trp Tyr Trp Gly Pro Ser Leu Tyr Ser Ile 
        195                 200                 205             
Val Ser Pro Phe Ile Pro Leu Leu Pro Ile Phe Phe Cys Leu Trp Val 
    210                 215                 220                 
Tyr Ile 
225     

<210>  2
<211>  226
<212>  PRT
<213>  BS(Hepatitis B virus)

<400>  2
Met Glu Asn Ile Ala Ser Gly Leu Leu Gly Pro Leu Leu Val Leu Gln 
1               5                   10                  15      
Ala Gly Phe Phe Leu Leu Thr Lys Ile Leu Thr Ile Pro Gln Ser Leu 
            20                  25                  30          
Asp Ser Trp Trp Thr Ser Leu Asn Phe Leu Gly Gly Thr Pro Val Cys 
        35                  40                  45              
Leu Gly Gln Asn Ser Gln Ser Gln Ile Ser Ser His Ser Pro Thr Cys 
    50                  55                  60                  
Cys Pro Pro Ile Cys Pro Gly Tyr Arg Trp Met Cys Leu Arg Arg Phe 
65                  70                  75                  80  
Ile Ile Phe Leu Cys Ile Leu Leu Leu Cys Leu Ile Phe Leu Leu Val 
                85                  90                  95      
Leu Leu Asp Tyr Gln Gly Met Leu Pro Val Cys Pro Leu Ile Pro Gly 
            100                 105                 110         
Ser Ser Thr Thr Ser Thr Gly Pro Cys Lys Thr Cys Thr Thr Pro Ala 
        115                 120                 125             
Gln Gly Thr Ser Met Phe Pro Ser Cys Cys Cys Thr Lys Pro Thr Asp 
    130                 135                 140                 
Gly Asn Cys Thr Cys Ile Pro Ile Pro Ser Ser Trp Ala Phe Ala Lys 
145                 150                 155                 160 
Tyr Leu Trp Glu Trp Ala Ser Val Arg Phe Ser Trp Leu Ser Leu Leu 
                165                 170                 175     
Val Pro Phe Val Gln Trp Phe Val Gly Leu Ser Pro Thr Val Trp Leu 
            180                 185                 190         
Ser Val Ile Trp Met Met Trp Tyr Trp Gly Pro Ser Leu Tyr Asn Ile 
        195                 200                 205             
Leu Ser Pro Phe Met Pro Leu Leu Pro Ile Phe Phe Cys Leu Trp Val 
    210                 215                 220                 
Tyr Ile 
225     

<210>  3
<211>  226
<212>  PRT
<213>  CS(Hepatitis B virus)

<400>  3
Met Glu Ser Thr Thr Ser Gly Phe Leu Gly Pro Leu Leu Val Leu Gln 
1               5                   10                  15      
Ala Gly Phe Phe Leu Leu Thr Arg Ile Leu Thr Ile Pro Gln Ser Leu 
            20                  25                  30          
Asp Ser Trp Trp Thr Ser Leu Asn Phe Leu Gly Gly Ala Pro Thr Cys 
        35                  40                  45              
Pro Gly Gln Asn Ser Gln Ser Pro Thr Ser Asn His Ser Pro Thr Ser 
    50                  55                  60                  
Cys Pro Pro Ile Cys Pro Gly Tyr Arg Trp Met Cys Leu Arg Arg Phe 
65                  70                  75                  80  
Ile Ile Phe Leu Phe Ile Leu Leu Leu Cys Leu Ile Phe Leu Leu Val 
                85                  90                  95      
Leu Leu Asp Tyr Gln Gly Met Leu Pro Val Cys Pro Leu Leu Pro Gly 
            100                 105                 110         
Thr Ser Thr Thr Ser Thr Gly Pro Cys Lys Thr Cys Thr Ser Pro Ala 
        115                 120                 125             
Gln Gly Thr Ser Met Phe Pro Ser Cys Cys Cys Thr Lys Pro Ser Asp 
    130                 135                 140                 
Gly Asn Cys Thr Cys Ile Pro Ile Pro Ser Ser Trp Ala Phe Ala Arg 
145                 150                 155                 160 
Phe Leu Trp Glu Trp Ala Ser Val Arg Phe Ser Trp Leu Ser Leu Leu 
                165                 170                 175     
Val Pro Phe Val Gln Trp Phe Val Gly Leu Ser Pro Thr Val Trp Leu 
            180                 185                 190         
Ser Val Ile Trp Met Met Trp Tyr Trp Gly Pro Cys Leu Tyr Asn Ile 
        195                 200                 205             
Leu Ser Pro Phe Leu Pro Leu Leu Pro Ile Phe Phe Cys Leu Trp Val 
    210                 215                 220                 
Tyr Ile 
225     

<210>  4
<211>  226
<212>  PRT
<213>  DS(Hepatitis B virus)

<400>  4
Met Glu Asn Ile Thr Ser Gly Phe Leu Gly Pro Leu Leu Val Leu Gln 
1               5                   10                  15      
Ala Gly Phe Phe Leu Leu Thr Arg Ile Leu Thr Ile Pro Gln Ser Leu 
            20                  25                  30          
Asp Ser Trp Trp Thr Ser Leu Asn Phe Leu Gly Gly Thr Thr Val Cys 
        35                  40                  45              
Leu Gly Gln Asn Ser Gln Ser Pro Thr Ser Asn His Ser Pro Thr Ser 
    50                  55                  60                  
Cys Pro Pro Thr Cys Pro Gly Tyr Arg Trp Met Cys Leu Arg Arg Phe 
65                  70                  75                  80  
Ile Ile Phe Leu Phe Ile Leu Leu Leu Cys Leu Ile Phe Leu Leu Val 
                85                  90                  95      
Leu Leu Asp Tyr Gln Gly Met Leu Pro Val Cys Pro Leu Ile Pro Gly 
            100                 105                 110         
Ser Ser Thr Thr Ser Val Gly Pro Cys Arg Thr Cys Thr Thr Thr Val 
        115                 120                 125             
Gln Gly Thr Ser Met Tyr Pro Ser Cys Cys Cys Thr Lys Pro Ser Asp 
    130                 135                 140                 
Gly Asn Cys Thr Cys Ile Pro Ile Pro Ser Ser Trp Ala Phe Gly Lys 
145                 150                 155                 160 
Phe Leu Trp Glu Trp Ala Ser Ala Arg Phe Ser Trp Leu Ser Leu Leu 
                165                 170                 175     
Val Pro Phe Val Gln Trp Phe Val Gly Leu Ser Pro Thr Val Trp Leu 
            180                 185                 190         
Ser Val Ile Trp Met Met Trp Tyr Trp Gly Pro Ser Leu Tyr Ser Ile 
        195                 200                 205             
Leu Ser Pro Phe Leu Pro Leu Leu Pro Ile Phe Phe Cys Leu Trp Val 
    210                 215                 220                 
Tyr Ile 
225     

<210>  5
<211>  226
<212>  PRT
<213>  ES(Hepatitis B virus)

<400>  5
Met Glu Gly Ile Thr Ser Gly Phe Leu Gly Pro Leu Leu Val Leu Gln 
1               5                   10                  15      
Ala Gly Phe Phe Leu Leu Thr Lys Ile Leu Thr Ile Pro Gln Ser Leu 
            20                  25                  30          
Asp Ser Trp Trp Thr Ser Leu Asn Phe Leu Gly Gly Ala Pro Val Cys 
        35                  40                  45              
Leu Gly Gln Asn Ser Gln Ser Pro Ile Ser Asn His Ser Pro Thr Ser 
    50                  55                  60                  
Cys Pro Pro Ile Cys Pro Gly Tyr Arg Trp Met Cys Leu Arg Arg Phe 
65                  70                  75                  80  
Ile Ile Phe Leu Phe Ile Leu Leu Leu Cys Leu Ile Phe Leu Leu Val 
                85                  90                  95      
Leu Leu Asp Tyr Gln Gly Met Leu Pro Val Cys Pro Leu Ile Pro Gly 
            100                 105                 110         
Ser Ser Thr Thr Ser Thr Gly Pro Cys Arg Thr Cys Thr Thr Leu Ala 
        115                 120                 125             
Gln Gly Thr Ser Met Phe Pro Ser Cys Cys Cys Leu Lys Pro Ser Asp 
    130                 135                 140                 
Gly Asn Cys Thr Cys Ile Pro Ile Pro Ser Ser Trp Ala Phe Gly Lys 
145                 150                 155                 160 
Phe Leu Trp Glu Trp Ala Ser Ala Arg Phe Ser Trp Leu Ser Leu Leu 
                165                 170                 175     
Val Pro Phe Val Gln Trp Phe Ala Gly Leu Ser Pro Thr Val Trp Leu 
            180                 185                 190         
Ser Val Ile Trp Met Met Trp Tyr Trp Gly Pro Ser Leu Tyr Asn Ile 
        195                 200                 205             
Leu Ser Pro Phe Ile Pro Leu Leu Pro Ile Phe Phe Cys Leu Trp Val 
    210                 215                 220                 
Tyr Ile 
225     

<210>  6
<211>  226
<212>  PRT
<213>  FS(Hepatitis B virus)

<400>  6
Met Asp Ser Ile Thr Ser Gly Leu Leu Gly Pro Leu Leu Val Leu Gln 
1               5                   10                  15      
Ala Val Cys Phe Leu Leu Thr Lys Ile Leu Thr Ile Pro Gln Ser Leu 
            20                  25                  30          
Asp Ser Trp Trp Thr Ser Leu Asn Phe Leu Gly Gly Thr Pro Gly Cys 
        35                  40                  45              
Pro Gly Gln Asn Ser Gln Ser Pro Thr Ser Asn His Leu Pro Thr Ser 
    50                  55                  60                  
Cys Pro Pro Thr Cys Pro Gly Tyr Arg Trp Met Cys Leu Arg Arg Phe 
65                  70                  75                  80  
Ile Ile Phe Leu Phe Ile Leu Leu Leu Cys Leu Ile Phe Leu Leu Val 
                85                  90                  95      
Leu Leu Asp Tyr Gln Gly Met Leu Pro Val Cys Pro Leu Leu Pro Gly 
            100                 105                 110         
Ser Thr Thr Thr Ser Thr Gly Pro Cys Lys Thr Cys Thr Thr Leu Ala 
        115                 120                 125             
Gln Gly Thr Ser Met Phe Pro Ser Cys Cys Cys Ser Lys Pro Trp Asp 
    130                 135                 140                 
Gly Asn Cys Thr Cys Ile Pro Ile Pro Ser Ser Trp Ala Leu Gly Lys 
145                 150                 155                 160 
Tyr Leu Trp Glu Trp Ala Ser Ala Arg Phe Ser Trp Leu Ser Leu Leu 
                165                 170                 175     
Val Gln Phe Val Gln Trp Cys Val Gly Leu Ser Pro Thr Val Trp Leu 
            180                 185                 190         
Leu Val Ile Trp Met Ile Trp Tyr Trp Gly Pro Asn Leu Cys Ser Ile 
        195                 200                 205             
Leu Ser Pro Phe Ile Pro Leu Leu Pro Ile Phe Cys Tyr Leu Trp Val 
    210                 215                 220                 
Ser Ile 
225     

<210>  7
<211>  226
<212>  PRT
<213>  GS(Hepatitis B virus)

<400>  7
Met Glu Asn Ile Thr Ser Gly Phe Leu Gly Pro Leu Leu Val Leu Gln 
1               5                   10                  15      
Ala Gly Phe Phe Leu Leu Thr Arg Ile Leu Thr Ile Pro Gln Asn Leu 
            20                  25                  30          
Asp Ser Trp Trp Thr Ser Leu Asn Phe Leu Gly Gly Val Pro Val Cys 
        35                  40                  45              
Pro Gly Leu Asn Ser Gln Ser Pro Thr Ser Asn His Ser Pro Ile Ser 
    50                  55                  60                  
Cys Pro Pro Thr Cys Pro Gly Tyr Arg Trp Met Cys Leu Arg Arg Phe 
65                  70                  75                  80  
Ile Ile Phe Leu Phe Ile Leu Leu Leu Cys Leu Ile Phe Leu Leu Val 
                85                  90                  95      
Leu Leu Asp Tyr Gln Gly Met Leu Pro Val Cys Pro Leu Ile Pro Gly 
            100                 105                 110         
Ser Ser Thr Thr Ser Thr Gly Pro Cys Lys Thr Cys Thr Thr Pro Ala 
        115                 120                 125             
Gln Gly Asn Ser Met Tyr Pro Ser Cys Cys Cys Thr Lys Pro Ser Asp 
    130                 135                 140                 
Gly Asn Cys Thr Cys Ile Pro Ile Pro Ser Ser Trp Ala Phe Ala Lys 
145                 150                 155                 160 
Tyr Leu Trp Glu Trp Ala Ser Val Arg Phe Ser Trp Leu Ser Leu Leu 
                165                 170                 175     
Val Pro Phe Val Gln Trp Phe Val Gly Leu Ser Pro Thr Val Trp Leu 
            180                 185                 190         
Ser Ala Ile Trp Met Met Trp Tyr Trp Gly Pro Asn Leu Tyr Asn Ile 
        195                 200                 205             
Leu Ser Pro Phe Ile Pro Leu Leu Pro Ile Phe Phe Cys Leu Trp Val 
    210                 215                 220                 
Tyr Ile 
225     

<210>  8
<211>  226
<212>  PRT
<213>  HS(Hepatitis B virus)

<400>  8
Met Glu Asn Ile Thr Ser Gly Leu Leu Gly Pro Leu Leu Val Leu Gln 
1               5                   10                  15      
Ala Val Cys Phe Leu Leu Thr Lys Ile Leu Thr Ile Pro Lys Ser Leu 
            20                  25                  30          
Asp Ser Trp Trp Thr Ser Leu Asn Phe Leu Gly Val Pro Pro Gly Cys 
        35                  40                  45              
Pro Gly Gln Asn Ser Gln Ser Pro Ile Ser Asn His Leu Pro Thr Ser 
    50                  55                  60                  
Cys Pro Pro Thr Cys Pro Gly Tyr Arg Trp Met Cys Leu Arg Arg Phe 
65                  70                  75                  80  
Ile Ile Phe Leu Phe Ile Leu Leu Leu Cys Leu Ile Phe Leu Leu Val 
                85                  90                  95      
Leu Leu Asp Tyr Gln Gly Met Leu Pro Val Cys Pro Leu Leu Pro Gly 
            100                 105                 110         
Ser Thr Thr Thr Ser Thr Gly Pro Cys Lys Thr Cys Thr Thr Leu Ala 
        115                 120                 125             
Gln Gly Thr Ser Met Phe Pro Ser Cys Cys Cys Thr Lys Pro Ser Asp 
    130                 135                 140                 
Gly Asn Cys Thr Cys Ile Pro Ile Pro Ser Ser Trp Ala Phe Gly Lys 
145                 150                 155                 160 
Tyr Leu Trp Glu Trp Ala Ser Ala Arg Phe Ser Trp Leu Ser Leu Leu 
                165                 170                 175     
Val Gln Phe Val Gln Trp Cys Val Gly Leu Ser Pro Thr Val Trp Leu 
            180                 185                 190         
Leu Val Ile Trp Met Ile Trp Tyr Trp Gly Pro Asn Leu Cys Ser Ile 
        195                 200                 205             
Leu Ser Pro Phe Ile Pro Leu Leu Pro Ile Phe Cys Tyr Leu Trp Ala 
    210                 215                 220                 
Ser Ile 
225     

<210>  9
<211>  226
<212>  PRT
<213>  BS-L13Rͻ(Artificial Sequence)

<400>  9
Met Glu Asn Ile Ala Ser Gly Leu Leu Gly Pro Leu Arg Val Leu Gln 
1               5                   10                  15      
Ala Gly Phe Phe Leu Leu Thr Lys Ile Leu Thr Ile Pro Gln Ser Leu 
            20                  25                  30          
Asp Ser Trp Trp Thr Ser Leu Asn Phe Leu Gly Glu Thr Pro Val Cys 
        35                  40                  45              
Leu Gly Gln Asn Ser Gln Ser Gln Ile Ser Ser His Ser Pro Thr Cys 
    50                  55                  60                  
Cys Pro Pro Ile Cys Pro Gly Tyr Arg Trp Met Cys Leu Arg Arg Phe 
65                  70                  75                  80  
Ile Ile Phe Leu Cys Ile Leu Leu Leu Cys Leu Ile Phe Leu Leu Val 
                85                  90                  95      
Leu Leu Asp Tyr Gln Gly Met Leu Pro Val Cys Pro Leu Ile Pro Gly 
            100                 105                 110         
Ser Ser Thr Thr Ser Thr Gly Pro Cys Lys Thr Cys Thr Thr Pro Ala 
        115                 120                 125             
Gln Gly Thr Ser Met Phe Pro Ser Cys Cys Cys Thr Lys Pro Thr Asp 
    130                 135                 140                 
Gly Asn Cys Thr Cys Ile Pro Ile Pro Ser Ser Trp Ala Phe Ala Lys 
145                 150                 155                 160 
Tyr Leu Trp Glu Trp Ala Ser Val Arg Phe Ser Trp Leu Ser Leu Leu 
                165                 170                 175     
Val Pro Phe Val Gln Trp Phe Val Gly Leu Ser Pro Thr Val Trp Leu 
            180                 185                 190         
Ser Val Ile Trp Met Met Trp Tyr Trp Gly Pro Ser Leu Tyr Asn Ile 
        195                 200                 205             
Leu Ser Pro Phe Met Pro Leu Leu Pro Ile Phe Phe Cys Leu Trp Val 
    210                 215                 220                 
Tyr Ile 
225     

<210>  10
<211>  226
<212>  PRT
<213>  BS-L13Dͻ(Artificial Sequence)

<400>  10
Met Glu Asn Ile Ala Ser Gly Leu Leu Gly Pro Leu Asp Val Leu Gln 
1               5                   10                  15      
Ala Gly Phe Phe Leu Leu Thr Lys Ile Leu Thr Ile Pro Gln Ser Leu 
            20                  25                  30          
Asp Ser Trp Trp Thr Ser Leu Asn Phe Leu Gly Glu Thr Pro Val Cys 
        35                  40                  45              
Leu Gly Gln Asn Ser Gln Ser Gln Ile Ser Ser His Ser Pro Thr Cys 
    50                  55                  60                  
Cys Pro Pro Ile Cys Pro Gly Tyr Arg Trp Met Cys Leu Arg Arg Phe 
65                  70                  75                  80  
Ile Ile Phe Leu Cys Ile Leu Leu Leu Cys Leu Ile Phe Leu Leu Val 
                85                  90                  95      
Leu Leu Asp Tyr Gln Gly Met Leu Pro Val Cys Pro Leu Ile Pro Gly 
            100                 105                 110         
Ser Ser Thr Thr Ser Thr Gly Pro Cys Lys Thr Cys Thr Thr Pro Ala 
        115                 120                 125             
Gln Gly Thr Ser Met Phe Pro Ser Cys Cys Cys Thr Lys Pro Thr Asp 
    130                 135                 140                 
Gly Asn Cys Thr Cys Ile Pro Ile Pro Ser Ser Trp Ala Phe Ala Lys 
145                 150                 155                 160 
Tyr Leu Trp Glu Trp Ala Ser Val Arg Phe Ser Trp Leu Ser Leu Leu 
                165                 170                 175     
Val Pro Phe Val Gln Trp Phe Val Gly Leu Ser Pro Thr Val Trp Leu 
            180                 185                 190         
Ser Val Ile Trp Met Met Trp Tyr Trp Gly Pro Ser Leu Tyr Asn Ile 
        195                 200                 205             
Leu Ser Pro Phe Met Pro Leu Leu Pro Ile Phe Phe Cys Leu Trp Val 
    210                 215                 220                 
Tyr Ile 
225     

<210>  11
<211>  226
<212>  PRT
<213>  BS-L13Eͻ(Artificial Sequence)

<400>  11
Met Glu Asn Ile Ala Ser Gly Leu Leu Gly Pro Leu Glu Val Leu Gln 
1               5                   10                  15      
Ala Gly Phe Phe Leu Leu Thr Lys Ile Leu Thr Ile Pro Gln Ser Leu 
            20                  25                  30          
Asp Ser Trp Trp Thr Ser Leu Asn Phe Leu Gly Glu Thr Pro Val Cys 
        35                  40                  45              
Leu Gly Gln Asn Ser Gln Ser Gln Ile Ser Ser His Ser Pro Thr Cys 
    50                  55                  60                  
Cys Pro Pro Ile Cys Pro Gly Tyr Arg Trp Met Cys Leu Arg Arg Phe 
65                  70                  75                  80  
Ile Ile Phe Leu Cys Ile Leu Leu Leu Cys Leu Ile Phe Leu Leu Val 
                85                  90                  95      
Leu Leu Asp Tyr Gln Gly Met Leu Pro Val Cys Pro Leu Ile Pro Gly 
            100                 105                 110         
Ser Ser Thr Thr Ser Thr Gly Pro Cys Lys Thr Cys Thr Thr Pro Ala 
        115                 120                 125             
Gln Gly Thr Ser Met Phe Pro Ser Cys Cys Cys Thr Lys Pro Thr Asp 
    130                 135                 140                 
Gly Asn Cys Thr Cys Ile Pro Ile Pro Ser Ser Trp Ala Phe Ala Lys 
145                 150                 155                 160 
Tyr Leu Trp Glu Trp Ala Ser Val Arg Phe Ser Trp Leu Ser Leu Leu 
                165                 170                 175     
Val Pro Phe Val Gln Trp Phe Val Gly Leu Ser Pro Thr Val Trp Leu 
            180                 185                 190         
Ser Val Ile Trp Met Met Trp Tyr Trp Gly Pro Ser Leu Tyr Asn Ile 
        195                 200                 205             
Leu Ser Pro Phe Met Pro Leu Leu Pro Ile Phe Phe Cys Leu Trp Val 
    210                 215                 220                 
Tyr Ile 
225     

<210>  12
<211>  226
<212>  PRT
<213>  BS-L13Kͻ(Artificial Sequence)

<400>  12
Met Glu Asn Ile Ala Ser Gly Leu Leu Gly Pro Leu Lys Val Leu Gln 
1               5                   10                  15      
Ala Gly Phe Phe Leu Leu Thr Lys Ile Leu Thr Ile Pro Gln Ser Leu 
            20                  25                  30          
Asp Ser Trp Trp Thr Ser Leu Asn Phe Leu Gly Glu Thr Pro Val Cys 
        35                  40                  45              
Leu Gly Gln Asn Ser Gln Ser Gln Ile Ser Ser His Ser Pro Thr Cys 
    50                  55                  60                  
Cys Pro Pro Ile Cys Pro Gly Tyr Arg Trp Met Cys Leu Arg Arg Phe 
65                  70                  75                  80  
Ile Ile Phe Leu Cys Ile Leu Leu Leu Cys Leu Ile Phe Leu Leu Val 
                85                  90                  95      
Leu Leu Asp Tyr Gln Gly Met Leu Pro Val Cys Pro Leu Ile Pro Gly 
            100                 105                 110         
Ser Ser Thr Thr Ser Thr Gly Pro Cys Lys Thr Cys Thr Thr Pro Ala 
        115                 120                 125             
Gln Gly Thr Ser Met Phe Pro Ser Cys Cys Cys Thr Lys Pro Thr Asp 
    130                 135                 140                 
Gly Asn Cys Thr Cys Ile Pro Ile Pro Ser Ser Trp Ala Phe Ala Lys 
145                 150                 155                 160 
Tyr Leu Trp Glu Trp Ala Ser Val Arg Phe Ser Trp Leu Ser Leu Leu 
                165                 170                 175     
Val Pro Phe Val Gln Trp Phe Val Gly Leu Ser Pro Thr Val Trp Leu 
            180                 185                 190         
Ser Val Ile Trp Met Met Trp Tyr Trp Gly Pro Ser Leu Tyr Asn Ile 
        195                 200                 205             
Leu Ser Pro Phe Met Pro Leu Leu Pro Ile Phe Phe Cys Leu Trp Val 
    210                 215                 220                 
Tyr Ile 
225     

<210>  13
<211>  681
<212>  DNA
<213>  AS׵ĺ(Hepatitis B virus)

<400>  13
atggagaaca tcacatcagg attcctagga cccctgctcg tgttacaggc ggggtttttc        60
ttgttgacaa gaatcctcac aataccgcag agtctagact cgtggtggac ttctctcaat       120
tttctagggg gatcacccgt gtgtcttggc caaaattcgc agtccccaac ctccaatcac       180
tcaccaacct cctgtcctcc aatttgtcct ggttatcgct ggatgtgtct gcggcgtttt       240
atcatattcc tcttcatcct gctgctatgc ctcatcttct tattggttct tctggattat       300
caaggtatgt tgcccgtttg tcctctaatt ccaggatcaa caacaaccag tacgggacca       360
tgcaaaacct gcacgactcc tgctcaaggc aactctatgt ttccctcatg ttgctgtaca       420
aaacctacgg atggaaattg cacctgtatt cccatcccat cgtcctgggc tttcgcaaaa       480
tacctatggg agtgggcctc agtccgtttc tcttggctca gtttactagt gccatttgtt       540
cagtggttcg tagggctttc ccccactgtt tggctttcag ctatatggat gatgtggtat       600
tgggggccaa gtctgtacag catcgtgagt ccctttatac cgctgttacc aattttcttt       660
tgtctctggg tatacattta a                                                 681

<210>  14
<211>  681
<212>  DNA
<213>  BS׵ĺ(Hepatitis B virus)

<400>  14
atggagaaca tcgcatcagg actcctagga cccctgctcg tgttacaggc ggggtttttc        60
ttgttgacaa aaatcctcac aataccacag agtctagact cgtggtggac ttctctcaat       120
tttctagggg gaacacccgt gtgtcttggc caaaattcgc agtcccaaat ctccagtcac       180
tcaccaacct gttgtcctcc aatttgtcct ggttatcgct ggatgtgtct gcggcgtttt       240
atcatcttcc tctgcatcct gctgctatgc ctcatcttct tgttggttct tctggactat       300
caaggtatgt tgcccgtttg tcctctaatt ccaggatcat caacaaccag caccggacca       360
tgcaaaacct gcacaactcc tgctcaagga acctctatgt ttccctcatg ttgctgtaca       420
aaacctacgg acggaaactg cacctgtatt cccatcccat catcttgggc tttcgcaaaa       480
tacctatggg agtgggcctc agtccgtttc tcttggctca gtttactagt gccatttgtt       540
cagtggttcg tagggctttc ccccactgtc tggctttcag ttatatggat gatgtggtat       600
tgggggccaa gtctgtacaa catcttgagt ccctttatgc cgctgttacc aattttcttt       660
tgtctttggg tatacattta a                                                 681

<210>  15
<211>  681
<212>  DNA
<213>  CS׵ĺ(Hepatitis B virus)

<400>  15
atggagagca caacatcagg attcctagga cccctgctcg tgttacaggc ggggtttttc        60
ttgttgacaa gaatcctcac aataccacag agtctagact cgtggtggac ttctctcaat       120
tttctagggg gagcacccac gtgtcctggc caaaattcgc agtccccaac ctccaatcac       180
tcaccaacct cttgtcctcc aatttgtcct ggctatcgct ggatgtgtct gcggcgtttt       240
atcatattcc tcttcatcct gctgctatgc ctcatcttct tgttggttct tctggactac       300
caaggtatgt tgcccgtttg tcctctactt ccaggaacat caactaccag cacgggacca       360
tgcaagacct gcacgagtcc tgctcaagga acctctatgt ttccctcttg ttgctgtaca       420
aaaccttcgg acggaaactg cacttgtatt cccatcccat catcctgggc tttcgcaaga       480
ttcctatggg agtgggcctc agtccgtttc tcctggctca gtttactagt gccatttgtt       540
cagtggttcg tagggctttc ccccactgtt tggctttcag ttatatggat gatgtggtat       600
tgggggccat gtctgtacaa catcttgagt ccctttttac ctctattacc aattttcttt       660
tgtctttggg tatacatttg a                                                 681

<210>  16
<211>  681
<212>  DNA
<213>  DS׵ĺ(Hepatitis B virus)

<400>  16
atggagaaca tcacatcagg attcctagga cccctgctcg tgttacaggc ggggtttttc        60
ttgttgacaa gaatcctcac aataccgcag agtctagact cgtggtggac ttctctcaat       120
tttctagggg ggaccaccgt gtgtcttggc caaaattcgc agtccccaac ctccaatcac       180
tcaccaacct cctgtcctcc aacttgtcct ggttatcgct ggatgtgtct gcggcgtttt       240
atcatcttcc tcttcatcct gctgctatgc ctcatcttct tgttggttct tctggactat       300
caaggtatgt tgcccgtttg tcctctaatt ccaggatctt caaccaccag cgtgggacca       360
tgcagaacct gcacgactac tgttcaagga acctctatgt atccctcctg ttgctgtacc       420
aaaccttcgg acggaaattg cacctgtatt cccatcccat catcctgggc tttcggaaaa       480
ttcctatggg agtgggcctc agcccgtttc tcctggctca gtttactagt gccatttgtt       540
cagtggttcg tagggctttc ccccactgtt tggctttcag ttatatggat gatgtggtat       600
tgggggccaa gtctgtacag catcttgagt ccctttttac cgctgttacc aattttcttt       660
tgtctttggg tatacattta a                                                 681

<210>  17
<211>  681
<212>  DNA
<213>  ES׵ĺ(Hepatitis B virus)

<400>  17
atggaaggca tcacatcagg attcctagga cccctgctcg tgttacaggc ggggtttttc        60
ttgttgacaa aaatcctcac aataccgcag agtctagact cgtggtggac ttctctcaat       120
tttctagggg gagctcccgt gtgtcttggc caaaattcgc agtccccaat ctccaatcac       180
tcaccaacct cttgtcctcc aatttgtcct ggctatcgct ggatgtgtct gcggcgtttt       240
atcatcttcc tcttcatcct gctgctatgc ctcatcttct tgttggttct tctggactat       300
caaggtatgt tgcccgtttg tcctctaatt ccaggatcat caaccaccag tacgggaccc       360
tgccgaacct gcacgactct tgctcaagga acctctatgt ttccctcatg ttgttgttta       420
aaaccttcgg acggaaattg cacttgtatt cccatcccat catcatgggc tttcggaaaa       480
ttcctatggg agtgggcctc agcccgtttc tcctggctca gtttactagt gccatttgtt       540
cagtggttcg ccgggctttc ccccactgtc tggctttcag ttatatggat gatgtggtat       600
tgggggccaa gtctgtacaa catcttgagt ccctttatac ctctgttacc aattttcttt       660
tgtctttggg tatacattta a                                                 681

<210>  18
<211>  681
<212>  DNA
<213>  FS׵ĺ(Hepatitis B virus)

<400>  18
atggacagca tcacatcagg actcctagga cccctgctcg tgttacaggc ggtgtgtttc        60
ttgttgacaa aaatcctcac aataccacag agtctagact cgtggtggac ttctctcaat       120
tttctagggg gaacacccgg gtgtcctggc caaaattcgc agtccccaac ctccaatcac       180
ttaccaacct cctgtcctcc aacttgtcct ggctatcgct ggatgtgtct gcggcgtttt       240
atcatcttcc tcttcatcct gctgctatgc ctcatcttct tgttggttct tctggactat       300
caaggtatgt tgcccgtttg tcctctactt ccaggatcaa cgaccaccag cacgggacca       360
tgcaaaacct gcacaactct tgctcaagga acctctatgt ttccctcttg ctgctgttcc       420
aaaccctggg acggaaactg cacttgtatt cccatcccat catcctgggc tttaggaaaa       480
tacctatggg agtgggcctc agcccgtttc tcctggctca gtttactagt gcaatttgtt       540
cagtggtgcg tagggctttc ccccactgtc tggcttttag ttatatggat gatttggtat       600
tgggggccaa atctgtgcag catcttgagt ccctttatac cgctgttacc aattttctgt       660
tatctgtggg tatccattta a                                                 681

<210>  19
<211>  681
<212>  DNA
<213>  GS׵ĺ(Hepatitis B virus)

<400>  19
atggagaaca tcacatcagg attcctagga cccctgctcg tgttacaggc ggggtttttc        60
ttgttgacaa gaatcctcac aataccgcag aatctagact cgtggtggac ttctctcaat       120
tttctagggg gagtgcccgt gtgtcctggc ctaaattcgc agtccccaac ctccaatcac       180
tcaccaatct cctgtcctcc aacttgtcct ggctatcgct ggatgtgtct gcggcgtttt       240
atcatattcc tcttcatcct gctgctatgc ctcatcttct tgttggttct tctggactat       300
caaggtatgt tgcccgtttg tcctctgatt ccaggatcct cgaccaccag tacgggaccc       360
tgcaaaacct gcacgactcc tgctcaaggc aactctatgt atccctcatg ttgctgtaca       420
aaaccttcgg acggaaattg cacctgtatt cccatcccat catcttgggc tttcgcaaaa       480
tacctatggg agtgggcctc agtccgtttc tcttggctca gtttactagt gccatttgtt       540
cagtggttcg tagggctttc ccccactgtc tggctttcag ctatatggat gatgtggtat       600
tgggggccaa atctgtacaa catcttgagt ccctttatac cgctgttacc aattttcttt       660
tgtctttggg tatacatcta a                                                 681

<210>  20
<211>  681
<212>  DNA
<213>  HS׵ĺ(Hepatitis B virus)

<400>  20
atggagaaca tcacatcagg actcctagga ccccttctcg tgttacaggc ggtgtgtttc        60
ttgttgacaa aaatcctcac aataccaaag agtctagact cgtggtggac ttctctcaat       120
tttctagggg taccacccgg gtgtcctggc caaaattcgc agtccccaat ctccaatcac       180
ttaccaacct cctgtcctcc aacttgtcct ggctatcgtt ggatgtgtct gcggcgtttt       240
atcatcttcc tcttcatcct gctgctatgc ctcatcttct tgttggttct tctggactat       300
caaggtatgt tgcccgtgtg tcctctactt ccaggatcta caaccaccag cacgggaccc       360
tgcaaaacct gcaccactct tgctcaagga acctctatgt ttccctcctg ctgctgtacc       420
aaaccttcgg acggaaattg cacctgtatt cccatcccat catcttgggc tttcggaaaa       480
tacctatggg agtgggcctc agcccgtttc tcttggctca gtttactagt gcaatttgtt       540
cagtggtgcg tagggctttc ccccactgtc tggcttttag ttatatggat gatctggtat       600
tgggggccaa atctgtgcag catcttgagt ccctttatac cgctgttacc aattttttgt       660
tatctgtggg catccatttg a                                                 681

<210>  21
<211>  681
<212>  DNA
<213>  BS-L13Rͻĺ(Artificial Sequence)

<400>  21
atggagaaca tcgcatcagg actcctagga cccctgcgcg tgttacaggc ggggtttttc        60
ttgttgacaa aaatcctcac aataccacag agtctagact cgtggtggac ttctctcaat       120
tttctagggg aaacacccgt gtgtcttggc caaaattcgc agtcccaaat ctccagtcac       180
tcaccaacct gttgtcctcc aatttgtcct ggttatcgct ggatgtgtct gcggcgtttt       240
atcatcttcc tctgcatcct gctgctatgc ctcatcttct tgttggttct tctggactat       300
caaggtatgt tgcccgtttg tcctctaatt ccaggatcat caactaccag caccggacca       360
tgcaaaacct gcacaactcc tgctcaagga acctctatgt ttccctcatg ttgctgtacc       420
aaacctacgg acggaaactg cacctgtatt cccatcccat catcttgggc tttcgcaaaa       480
tacctatggg agtgggcctc agtccgtttc tcttggctca gtttactagt gccatttgtt       540
cagtggttcg tagggctttc ccccactgtc tggctttcag ttatatggat gatgtggtat       600
tgggggccaa gtctgtacaa catcttgagt ccctttatgc cgctgttacc aattttcttt       660
tgtctttggg tatacattta a                                                 681

<210>  22
<211>  681
<212>  DNA
<213>  BS-L13Dͻĺ(Artificial Sequence)

<400>  22
atggagaaca tcgcatcagg actcctagga cccctggacg tgttacaggc ggggtttttc        60
ttgttgacaa aaatcctcac aataccacag agtctagact cgtggtggac ttctctcaat       120
tttctagggg aaacacccgt gtgtcttggc caaaattcgc agtcccaaat ctccagtcac       180
tcaccaacct gttgtcctcc aatttgtcct ggttatcgct ggatgtgtct gcggcgtttt       240
atcatcttcc tctgcatcct gctgctatgc ctcatcttct tgttggttct tctggactat       300
caaggtatgt tgcccgtttg tcctctaatt ccaggatcat caactaccag caccggacca       360
tgcaaaacct gcacaactcc tgctcaagga acctctatgt ttccctcatg ttgctgtacc       420
aaacctacgg acggaaactg cacctgtatt cccatcccat catcttgggc tttcgcaaaa       480
tacctatggg agtgggcctc agtccgtttc tcttggctca gtttactagt gccatttgtt       540
cagtggttcg tagggctttc ccccactgtc tggctttcag ttatatggat gatgtggtat       600
tgggggccaa gtctgtacaa catcttgagt ccctttatgc cgctgttacc aattttcttt       660
tgtctttggg tatacattta a                                                 681

<210>  23
<211>  681
<212>  DNA
<213>  BS-L13Eͻĺ(Artificial Sequence)

<400>  23
atggagaaca tcgcatcagg actcctagga cccctgcagg tgttacaggc ggggtttttc        60
ttgttgacaa aaatcctcac aataccacag agtctagact cgtggtggac ttctctcaat       120
tttctagggg aaacacccgt gtgtcttggc caaaattcgc agtcccaaat ctccagtcac       180
tcaccaacct gttgtcctcc aatttgtcct ggttatcgct ggatgtgtct gcggcgtttt       240
atcatcttcc tctgcatcct gctgctatgc ctcatcttct tgttggttct tctggactat       300
caaggtatgt tgcccgtttg tcctctaatt ccaggatcat caactaccag caccggacca       360
tgcaaaacct gcacaactcc tgctcaagga acctctatgt ttccctcatg ttgctgtacc       420
aaacctacgg acggaaactg cacctgtatt cccatcccat catcttgggc tttcgcaaaa       480
tacctatggg agtgggcctc agtccgtttc tcttggctca gtttactagt gccatttgtt       540
cagtggttcg tagggctttc ccccactgtc tggctttcag ttatatggat gatgtggtat       600
tgggggccaa gtctgtacaa catcttgagt ccctttatgc cgctgttacc aattttcttt       660
tgtctttggg tatacattta a                                                 681

<210>  24
<211>  681
<212>  DNA
<213>  BS-L13Kͻĺ(Artificial Sequence)

<400>  24
atggagaaca tcgcatcagg actcctagga cccctgaagg tgttacaggc ggggtttttc        60
ttgttgacaa aaatcctcac aataccacag agtctagact cgtggtggac ttctctcaat       120
tttctagggg aaacacccgt gtgtcttggc caaaattcgc agtcccaaat ctccagtcac       180
tcaccaacct gttgtcctcc aatttgtcct ggttatcgct ggatgtgtct gcggcgtttt       240
atcatcttcc tctgcatcct gctgctatgc ctcatcttct tgttggttct tctggactat       300
caaggtatgt tgcccgtttg tcctctaatt ccaggatcat caactaccag caccggacca       360
tgcaaaacct gcacaactcc tgctcaagga acctctatgt ttccctcatg ttgctgtacc       420
aaacctacgg acggaaactg cacctgtatt cccatcccat catcttgggc tttcgcaaaa       480
tacctatggg agtgggcctc agtccgtttc tcttggctca gtttactagt gccatttgtt       540
cagtggttcg tagggctttc ccccactgtc tggctttcag ttatatggat gatgtggtat       600
tgggggccaa gtctgtacaa catcttgagt ccctttatgc cgctgttacc aattttcttt       660
tgtctttggg tatacattta a                                                 681

<210>  25
<211>  33
<212>  DNA
<213>  BL13R-F(Artificial Sequence)

<400>  25
cccctgcgcg tgttacaggc ggggtttttc ttg                                     33

<210>  26
<211>  33
<212>  DNA
<213>  BL13D-F(Artificial Sequence)

<400>  26
cccctggacg tgttacaggc ggggtttttc ttg                                     33

<210>  27
<211>  33
<212>  DNA
<213>  BL13E-F(Artificial Sequence)

<400>  27
cccctggagg tgttacaggc ggggtttttc ttg                                     33

<210>  28
<211>  33
<212>  DNA
<213>  BL13K-F(Artificial Sequence)

<400>  28
cccctgaagg tgttacaggc ggggtttttc ttg                                     33

<210>  29
<211>  24
<212>  DNA
<213>  BL13-R(Artificial Sequence)

<400>  29
tcctaggagt cctgatgcga tgtt                                               24

<210>  30
<211>  32
<212>  DNA
<213>  S-F(Artificial Sequence)

<400>  30
cgcggatcca tggagaacat cgcatcagga ct                                      32

<210>  31
<211>  34
<212>  DNA
<213>  S-R(Artificial Sequence)

<400>  31
atttgcggcc gcttaaatgt atacccaaag acaa                                    34

