                         б

<110>  ҽƴѧ
 
<120>  һữøƱӦ

<130>  FPCH22160065P

<160>  28    

<170>  PatentIn version 3.5

<210>  1
<211>  390
<212>  PRT
<213>  ˹

<220>
<223>  Adenylase

<400>  1

Met His His His His His His His His Glu Asn Met Val Ser Ser Lys 
1               5                   10                  15      


Phe Lys Glu Leu Leu Tyr Thr Leu Gly Ile Pro Glu Asp Lys Val Glu 
            20                  25                  30          


Ile Leu Glu Ala Arg Gly Gly Ile Met Glu Asp Glu Phe Glu Gly Ile 
        35                  40                  45              


Arg Tyr Leu Arg Phe Lys Asn Ser Val Gly Lys Leu Arg Arg Gly Thr 
    50                  55                  60                  


Val Leu Phe Glu Asp Gly Thr Thr Val Phe Gly Phe Pro His Ile Lys 
65                  70                  75                  80  


Arg Ile Val Asn Leu Ser Ala Gly Val Arg Lys Ile Phe Lys Ser Ser 
                85                  90                  95      


Glu Phe Tyr Val Glu Glu Lys Val Asp Gly Tyr Asn Val Arg Val Val 
            100                 105                 110         


Lys Phe Lys Asp Arg Ile Leu Gly Ile Thr Arg Gly Gly Phe Ile Cys 
        115                 120                 125             


Pro Tyr Thr Thr Glu Arg Ile Ala Glu Phe Val Pro Glu Glu Phe Phe 
    130                 135                 140                 


Lys Asp His Lys Asp Leu Val Leu Val Gly Glu Met Ala Gly Pro Glu 
145                 150                 155                 160 


Ser Pro Tyr Leu Val Glu Gly Pro Pro Tyr Val Lys Glu Asp Ile Gln 
                165                 170                 175     


Phe Phe Leu Phe Asp Ile Gln Asp Ile Lys Thr Gly Ser Ser Leu Pro 
            180                 185                 190         


Val Glu Glu Arg Leu Lys Leu Ala Glu Glu Tyr Gly Ile Asn His Val 
        195                 200                 205             


Glu Val Phe Gly Arg Tyr Ser Tyr Lys Asp Ile Asp Asp Leu Tyr Glu 
    210                 215                 220                 


Leu Ile Glu Arg Leu Ser Arg Glu Gly Arg Glu Gly Ile Val Met Lys 
225                 230                 235                 240 


Ser Pro Asp Met Lys Lys Ile Val Lys Tyr Val Thr Pro Tyr Ala Asn 
                245                 250                 255     


Ile Asn Asp Ile Lys Ile Gly Ala Arg Val Phe Tyr Glu Leu Pro Gly 
            260                 265                 270         


Gly Tyr Phe Thr Ser Arg Ile Ser Arg Leu Ala Phe Tyr Ile Ala Glu 
        275                 280                 285             


Lys Lys Ile Arg Gly Glu Glu Leu His Asn Leu Ala Leu Gln Leu Gly 
    290                 295                 300                 


Lys Ala Leu Leu Gln Pro Leu Val Glu Ala Ile His Asp Val Thr Gln 
305                 310                 315                 320 


Gly Asp Val Ile Ala Glu Arg Phe Arg Val Arg Val Arg Lys Ile Glu 
                325                 330                 335     


Thr Ala Tyr Lys Met Val Thr His Phe Glu Lys Leu Gly Leu Glu Ile 
            340                 345                 350         


Glu Ile Glu Asp Ile Glu Glu Ile Glu Gly Gly Trp Arg Val Thr Phe 
        355                 360                 365             


Lys Arg Val Tyr Pro Glu Ala Thr Arg Glu Ile Arg Asp Leu Ile Gly 
    370                 375                 380                 


Gly Lys Ala Phe Val Asp 
385                 390 


<210>  2
<211>  306
<212>  PRT
<213>  ˹

<220>
<223>  T4 PNK

<400>  2

Met Lys Lys Ile Ile Leu Thr Ile Gly Cys Pro Gly Ser Gly Lys Ser 
1               5                   10                  15      


Thr Trp Ala Arg Glu Phe Ile Ala Lys Asn Pro Gly Phe Tyr Asn Ile 
            20                  25                  30          


Asn Arg Asp Asp Tyr Arg Gln Ser Ile Met Ala His Glu Glu Arg Asp 
        35                  40                  45              


Glu Tyr Lys Tyr Thr Lys Lys Lys Glu Gly Ile Val Thr Gly Met Gln 
    50                  55                  60                  


Phe Asp Thr Ala Lys Ser Ile Leu Tyr Gly Gly Asp Ser Val Lys Gly 
65                  70                  75                  80  


Val Ile Ile Ser Asp Thr Asn Leu Asn Pro Glu Arg Arg Leu Ala Trp 
                85                  90                  95      


Glu Thr Phe Ala Lys Glu Tyr Gly Trp Lys Val Glu His Lys Val Phe 
            100                 105                 110         


Asp Val Pro Trp Thr Glu Leu Val Lys Arg Asn Ser Lys Arg Gly Thr 
        115                 120                 125             


Lys Ala Val Pro Ile Asp Val Leu Arg Ser Met Tyr Lys Ser Met Arg 
    130                 135                 140                 


Glu Tyr Leu Gly Leu Pro Val Tyr Asn Gly Thr Pro Gly Lys Pro Lys 
145                 150                 155                 160 


Ala Val Ile Phe Asp Val Asp Gly Thr Leu Ala Lys Met Asn Gly Arg 
                165                 170                 175     


Gly Pro Tyr Asp Leu Glu Lys Cys Asp Thr Asp Val Ile Asn Pro Met 
            180                 185                 190         


Val Val Glu Leu Ser Lys Met Tyr Ala Leu Met Gly Tyr Gln Ile Val 
        195                 200                 205             


Val Val Ser Gly Arg Glu Ser Gly Thr Lys Glu Asp Pro Thr Lys Tyr 
    210                 215                 220                 


Tyr Arg Met Thr Arg Lys Trp Val Glu Asp Ile Ala Gly Val Pro Leu 
225                 230                 235                 240 


Val Met Gln Cys Gln Arg Glu Gln Gly Asp Thr Arg Lys Asp Asp Val 
                245                 250                 255     


Val Lys Glu Glu Ile Phe Trp Lys His Ile Ala Pro His Phe Asp Val 
            260                 265                 270         


Lys Leu Ala Ile Asp Asp Arg Thr Gln Val Val Glu Met Trp Arg Arg 
        275                 280                 285             


Ile Gly Val Glu Cys Trp Gln Val Ala Ser Gly Asp His His His His 
    290                 295                 300                 


His His 
305     


<210>  3
<211>  703
<212>  PRT
<213>  ˹

<220>
<223>  ںø

<400>  3

Met His His His His His His His His Glu Asn Met Val Ser Ser Lys 
1               5                   10                  15      


Phe Lys Glu Leu Leu Tyr Thr Leu Gly Ile Pro Glu Asp Lys Val Glu 
            20                  25                  30          


Ile Leu Glu Ala Arg Gly Gly Ile Met Glu Asp Glu Phe Glu Gly Ile 
        35                  40                  45              


Arg Tyr Leu Arg Phe Lys Asn Ser Val Gly Lys Leu Arg Arg Gly Thr 
    50                  55                  60                  


Val Leu Phe Glu Asp Gly Thr Thr Val Phe Gly Phe Pro His Ile Lys 
65                  70                  75                  80  


Arg Ile Val Asn Leu Ser Ala Gly Val Arg Lys Ile Phe Lys Ser Ser 
                85                  90                  95      


Glu Phe Tyr Val Glu Glu Lys Val Asp Gly Tyr Asn Val Arg Val Val 
            100                 105                 110         


Lys Phe Lys Asp Arg Ile Leu Gly Ile Thr Arg Gly Gly Phe Ile Cys 
        115                 120                 125             


Pro Tyr Thr Thr Glu Arg Ile Ala Glu Phe Val Pro Glu Glu Phe Phe 
    130                 135                 140                 


Lys Asp His Lys Asp Leu Val Leu Val Gly Glu Met Ala Gly Pro Glu 
145                 150                 155                 160 


Ser Pro Tyr Leu Val Glu Gly Pro Pro Tyr Val Lys Glu Asp Ile Gln 
                165                 170                 175     


Phe Phe Leu Phe Asp Ile Gln Asp Ile Lys Thr Gly Ser Ser Leu Pro 
            180                 185                 190         


Val Glu Glu Arg Leu Lys Leu Ala Glu Glu Tyr Gly Ile Asn His Val 
        195                 200                 205             


Glu Val Phe Gly Arg Tyr Ser Tyr Lys Asp Ile Asp Asp Leu Tyr Glu 
    210                 215                 220                 


Leu Ile Glu Arg Leu Ser Arg Glu Gly Arg Glu Gly Ile Val Met Lys 
225                 230                 235                 240 


Ser Pro Asp Met Lys Lys Ile Val Lys Tyr Val Thr Pro Tyr Ala Asn 
                245                 250                 255     


Ile Asn Asp Ile Lys Ile Gly Ala Arg Val Phe Tyr Glu Leu Pro Gly 
            260                 265                 270         


Gly Tyr Phe Thr Ser Arg Ile Ser Arg Leu Ala Phe Tyr Ile Ala Glu 
        275                 280                 285             


Lys Lys Ile Arg Gly Glu Glu Leu His Asn Leu Ala Leu Gln Leu Gly 
    290                 295                 300                 


Lys Ala Leu Leu Gln Pro Leu Val Glu Ala Ile His Asp Val Thr Gln 
305                 310                 315                 320 


Gly Asp Val Ile Ala Glu Arg Phe Arg Val Arg Val Arg Lys Ile Glu 
                325                 330                 335     


Thr Ala Tyr Lys Met Val Thr His Phe Glu Lys Leu Gly Leu Glu Ile 
            340                 345                 350         


Glu Ile Glu Asp Ile Glu Glu Ile Glu Gly Gly Trp Arg Val Thr Phe 
        355                 360                 365             


Lys Arg Val Tyr Pro Glu Ala Thr Arg Glu Ile Arg Asp Leu Ile Gly 
    370                 375                 380                 


Gly Lys Ala Phe Val Asp Ser Ser Gly Gly Ser Gly Gly Ser Gly Gly 
385                 390                 395                 400 


Ser Ala Gly Met Lys Lys Ile Ile Leu Thr Ile Gly Cys Pro Gly Ser 
                405                 410                 415     


Gly Lys Ser Thr Trp Ala Arg Glu Phe Ile Ala Lys Asn Pro Gly Phe 
            420                 425                 430         


Tyr Asn Ile Asn Arg Asp Asp Tyr Arg Gln Ser Ile Met Ala His Glu 
        435                 440                 445             


Glu Arg Asp Glu Tyr Lys Tyr Thr Lys Lys Lys Glu Gly Ile Val Thr 
    450                 455                 460                 


Gly Met Gln Phe Asp Thr Ala Lys Ser Ile Leu Tyr Gly Gly Asp Ser 
465                 470                 475                 480 


Val Lys Gly Val Ile Ile Ser Asp Thr Asn Leu Asn Pro Glu Arg Arg 
                485                 490                 495     


Leu Ala Trp Glu Thr Phe Ala Lys Glu Tyr Gly Trp Lys Val Glu His 
            500                 505                 510         


Lys Val Phe Asp Val Pro Trp Thr Glu Leu Val Lys Arg Asn Ser Lys 
        515                 520                 525             


Arg Gly Thr Lys Ala Val Pro Ile Asp Val Leu Arg Ser Met Tyr Lys 
    530                 535                 540                 


Ser Met Arg Glu Tyr Leu Gly Leu Pro Val Tyr Asn Gly Thr Pro Gly 
545                 550                 555                 560 


Lys Pro Lys Ala Val Ile Phe Asp Val Asp Gly Thr Leu Ala Lys Met 
                565                 570                 575     


Asn Gly Arg Gly Pro Tyr Asp Leu Glu Lys Cys Asp Thr Asp Val Ile 
            580                 585                 590         


Asn Pro Met Val Val Glu Leu Ser Lys Met Tyr Ala Leu Met Gly Tyr 
        595                 600                 605             


Gln Ile Val Val Val Ser Gly Arg Glu Ser Gly Thr Lys Glu Asp Pro 
    610                 615                 620                 


Thr Lys Tyr Tyr Arg Met Thr Arg Lys Trp Val Glu Asp Ile Ala Gly 
625                 630                 635                 640 


Val Pro Leu Val Met Gln Cys Gln Arg Glu Gln Gly Asp Thr Arg Lys 
                645                 650                 655     


Asp Asp Val Val Lys Glu Glu Ile Phe Trp Lys His Ile Ala Pro His 
            660                 665                 670         


Phe Asp Val Lys Leu Ala Ile Asp Asp Arg Thr Gln Val Val Glu Met 
        675                 680                 685             


Trp Arg Arg Ile Gly Val Glu Cys Trp Gln Val Ala Ser Gly Asp 
    690                 695                 700             


<210>  4
<211>  700
<212>  PRT
<213>  ˹

<220>
<223>  ںø

<400>  4

Met Glu Asn Met Val Ser Ser Lys Phe Lys Glu Leu Leu Tyr Thr Leu 
1               5                   10                  15      


Gly Ile Pro Glu Asp Lys Val Glu Ile Leu Glu Ala Arg Gly Gly Ile 
            20                  25                  30          


Met Glu Asp Glu Phe Glu Gly Ile Arg Tyr Leu Arg Phe Lys Asn Ser 
        35                  40                  45              


Val Gly Lys Leu Arg Arg Gly Thr Val Leu Phe Glu Asp Gly Thr Thr 
    50                  55                  60                  


Val Phe Gly Phe Pro His Ile Lys Arg Ile Val Asn Leu Ser Ala Gly 
65                  70                  75                  80  


Val Arg Lys Ile Phe Lys Ser Ser Glu Phe Tyr Val Glu Glu Lys Val 
                85                  90                  95      


Asp Gly Tyr Asn Val Arg Val Val Lys Phe Lys Asp Arg Ile Leu Gly 
            100                 105                 110         


Ile Thr Arg Gly Gly Phe Ile Cys Pro Tyr Thr Thr Glu Arg Ile Ala 
        115                 120                 125             


Glu Phe Val Pro Glu Glu Phe Phe Lys Asp His Lys Asp Leu Val Leu 
    130                 135                 140                 


Val Gly Glu Met Ala Gly Pro Glu Ser Pro Tyr Leu Val Glu Gly Pro 
145                 150                 155                 160 


Pro Tyr Val Lys Glu Asp Ile Gln Phe Phe Leu Phe Asp Ile Gln Asp 
                165                 170                 175     


Ile Lys Thr Gly Ser Ser Leu Pro Val Glu Glu Arg Leu Lys Leu Ala 
            180                 185                 190         


Glu Glu Tyr Gly Ile Asn His Val Glu Val Phe Gly Arg Tyr Ser Tyr 
        195                 200                 205             


Lys Asp Ile Asp Asp Leu Tyr Glu Leu Ile Glu Arg Leu Ser Arg Glu 
    210                 215                 220                 


Gly Arg Glu Gly Ile Val Met Lys Ser Pro Asp Met Lys Lys Ile Val 
225                 230                 235                 240 


Lys Tyr Val Thr Pro Tyr Ala Asn Ile Asn Asp Ile Lys Ile Gly Ala 
                245                 250                 255     


Arg Val Phe Tyr Glu Leu Pro Gly Gly Tyr Phe Thr Ser Arg Ile Ser 
            260                 265                 270         


Arg Leu Ala Phe Tyr Ile Ala Glu Lys Lys Ile Arg Gly Glu Glu Leu 
        275                 280                 285             


His Asn Leu Ala Leu Gln Leu Gly Lys Ala Leu Leu Gln Pro Leu Val 
    290                 295                 300                 


Glu Ala Ile His Asp Val Thr Gln Gly Asp Val Ile Ala Glu Arg Phe 
305                 310                 315                 320 


Arg Val Arg Val Arg Lys Ile Glu Thr Ala Tyr Lys Met Val Thr His 
                325                 330                 335     


Phe Glu Lys Leu Gly Leu Glu Ile Glu Ile Glu Asp Ile Glu Glu Ile 
            340                 345                 350         


Glu Gly Gly Trp Arg Val Thr Phe Lys Arg Val Tyr Pro Glu Ala Thr 
        355                 360                 365             


Arg Glu Ile Arg Asp Leu Ile Gly Gly Lys Ala Phe Val Asp Ser Ser 
    370                 375                 380                 


Gly Gly Ser Gly Gly Ser Gly Gly Ser Ala Gly Lys Lys Ile Ile Leu 
385                 390                 395                 400 


Thr Ile Gly Cys Pro Gly Ser Gly Lys Ser Thr Trp Ala Arg Glu Phe 
                405                 410                 415     


Ile Ala Lys Asn Pro Gly Phe Tyr Asn Ile Asn Arg Asp Asp Tyr Arg 
            420                 425                 430         


Gln Ser Ile Met Ala His Glu Glu Arg Asp Glu Tyr Lys Tyr Thr Lys 
        435                 440                 445             


Lys Lys Glu Gly Ile Val Thr Gly Met Gln Phe Asp Thr Ala Lys Ser 
    450                 455                 460                 


Ile Leu Tyr Gly Gly Asp Ser Val Lys Gly Val Ile Ile Ser Asp Thr 
465                 470                 475                 480 


Asn Leu Asn Pro Glu Arg Arg Leu Ala Trp Glu Thr Phe Ala Lys Glu 
                485                 490                 495     


Tyr Gly Trp Lys Val Glu His Lys Val Phe Asp Val Pro Trp Thr Glu 
            500                 505                 510         


Leu Val Lys Arg Asn Ser Lys Arg Gly Thr Lys Ala Val Pro Ile Asp 
        515                 520                 525             


Val Leu Arg Ser Met Tyr Lys Ser Met Arg Glu Tyr Leu Gly Leu Pro 
    530                 535                 540                 


Val Tyr Asn Gly Thr Pro Gly Lys Pro Lys Ala Val Ile Phe Asp Val 
545                 550                 555                 560 


Asp Gly Thr Leu Ala Lys Met Asn Gly Arg Gly Pro Tyr Asp Leu Glu 
                565                 570                 575     


Lys Cys Asp Thr Asp Val Ile Asn Pro Met Val Val Glu Leu Ser Lys 
            580                 585                 590         


Met Tyr Ala Leu Met Gly Tyr Gln Ile Val Val Val Ser Gly Arg Glu 
        595                 600                 605             


Ser Gly Thr Lys Glu Asp Pro Thr Lys Tyr Tyr Arg Met Thr Arg Lys 
    610                 615                 620                 


Trp Val Glu Asp Ile Ala Gly Val Pro Leu Val Met Gln Cys Gln Arg 
625                 630                 635                 640 


Glu Gln Gly Asp Thr Arg Lys Asp Asp Val Val Lys Glu Glu Ile Phe 
                645                 650                 655     


Trp Lys His Ile Ala Pro His Phe Asp Val Lys Leu Ala Ile Asp Asp 
            660                 665                 670         


Arg Thr Gln Val Val Glu Met Trp Arg Arg Ile Gly Val Glu Cys Trp 
        675                 680                 685             


Gln Val Ala Ser Gly Asp His His His His His His 
    690                 695                 700 


<210>  5
<211>  702
<212>  PRT
<213>  ˹

<220>
<223>  ںø

<400>  5

Met His His His His His His His His Lys Lys Ile Ile Leu Thr Ile 
1               5                   10                  15      


Gly Cys Pro Gly Ser Gly Lys Ser Thr Trp Ala Arg Glu Phe Ile Ala 
            20                  25                  30          


Lys Asn Pro Gly Phe Tyr Asn Ile Asn Arg Asp Asp Tyr Arg Gln Ser 
        35                  40                  45              


Ile Met Ala His Glu Glu Arg Asp Glu Tyr Lys Tyr Thr Lys Lys Lys 
    50                  55                  60                  


Glu Gly Ile Val Thr Gly Met Gln Phe Asp Thr Ala Lys Ser Ile Leu 
65                  70                  75                  80  


Tyr Gly Gly Asp Ser Val Lys Gly Val Ile Ile Ser Asp Thr Asn Leu 
                85                  90                  95      


Asn Pro Glu Arg Arg Leu Ala Trp Glu Thr Phe Ala Lys Glu Tyr Gly 
            100                 105                 110         


Trp Lys Val Glu His Lys Val Phe Asp Val Pro Trp Thr Glu Leu Val 
        115                 120                 125             


Lys Arg Asn Ser Lys Arg Gly Thr Lys Ala Val Pro Ile Asp Val Leu 
    130                 135                 140                 


Arg Ser Met Tyr Lys Ser Met Arg Glu Tyr Leu Gly Leu Pro Val Tyr 
145                 150                 155                 160 


Asn Gly Thr Pro Gly Lys Pro Lys Ala Val Ile Phe Asp Val Asp Gly 
                165                 170                 175     


Thr Leu Ala Lys Met Asn Gly Arg Gly Pro Tyr Asp Leu Glu Lys Cys 
            180                 185                 190         


Asp Thr Asp Val Ile Asn Pro Met Val Val Glu Leu Ser Lys Met Tyr 
        195                 200                 205             


Ala Leu Met Gly Tyr Gln Ile Val Val Val Ser Gly Arg Glu Ser Gly 
    210                 215                 220                 


Thr Lys Glu Asp Pro Thr Lys Tyr Tyr Arg Met Thr Arg Lys Trp Val 
225                 230                 235                 240 


Glu Asp Ile Ala Gly Val Pro Leu Val Met Gln Cys Gln Arg Glu Gln 
                245                 250                 255     


Gly Asp Thr Arg Lys Asp Asp Val Val Lys Glu Glu Ile Phe Trp Lys 
            260                 265                 270         


His Ile Ala Pro His Phe Asp Val Lys Leu Ala Ile Asp Asp Arg Thr 
        275                 280                 285             


Gln Val Val Glu Met Trp Arg Arg Ile Gly Val Glu Cys Trp Gln Val 
    290                 295                 300                 


Ala Ser Gly Asp Ser Ser Gly Gly Ser Gly Gly Ser Gly Gly Ser Ala 
305                 310                 315                 320 


Gly Glu Asn Met Val Ser Ser Lys Phe Lys Glu Leu Leu Tyr Thr Leu 
                325                 330                 335     


Gly Ile Pro Glu Asp Lys Val Glu Ile Leu Glu Ala Arg Gly Gly Ile 
            340                 345                 350         


Met Glu Asp Glu Phe Glu Gly Ile Arg Tyr Leu Arg Phe Lys Asn Ser 
        355                 360                 365             


Val Gly Lys Leu Arg Arg Gly Thr Val Leu Phe Glu Asp Gly Thr Thr 
    370                 375                 380                 


Val Phe Gly Phe Pro His Ile Lys Arg Ile Val Asn Leu Ser Ala Gly 
385                 390                 395                 400 


Val Arg Lys Ile Phe Lys Ser Ser Glu Phe Tyr Val Glu Glu Lys Val 
                405                 410                 415     


Asp Gly Tyr Asn Val Arg Val Val Lys Phe Lys Asp Arg Ile Leu Gly 
            420                 425                 430         


Ile Thr Arg Gly Gly Phe Ile Cys Pro Tyr Thr Thr Glu Arg Ile Ala 
        435                 440                 445             


Glu Phe Val Pro Glu Glu Phe Phe Lys Asp His Lys Asp Leu Val Leu 
    450                 455                 460                 


Val Gly Glu Met Ala Gly Pro Glu Ser Pro Tyr Leu Val Glu Gly Pro 
465                 470                 475                 480 


Pro Tyr Val Lys Glu Asp Ile Gln Phe Phe Leu Phe Asp Ile Gln Asp 
                485                 490                 495     


Ile Lys Thr Gly Ser Ser Leu Pro Val Glu Glu Arg Leu Lys Leu Ala 
            500                 505                 510         


Glu Glu Tyr Gly Ile Asn His Val Glu Val Phe Gly Arg Tyr Ser Tyr 
        515                 520                 525             


Lys Asp Ile Asp Asp Leu Tyr Glu Leu Ile Glu Arg Leu Ser Arg Glu 
    530                 535                 540                 


Gly Arg Glu Gly Ile Val Met Lys Ser Pro Asp Met Lys Lys Ile Val 
545                 550                 555                 560 


Lys Tyr Val Thr Pro Tyr Ala Asn Ile Asn Asp Ile Lys Ile Gly Ala 
                565                 570                 575     


Arg Val Phe Tyr Glu Leu Pro Gly Gly Tyr Phe Thr Ser Arg Ile Ser 
            580                 585                 590         


Arg Leu Ala Phe Tyr Ile Ala Glu Lys Lys Ile Arg Gly Glu Glu Leu 
        595                 600                 605             


His Asn Leu Ala Leu Gln Leu Gly Lys Ala Leu Leu Gln Pro Leu Val 
    610                 615                 620                 


Glu Ala Ile His Asp Val Thr Gln Gly Asp Val Ile Ala Glu Arg Phe 
625                 630                 635                 640 


Arg Val Arg Val Arg Lys Ile Glu Thr Ala Tyr Lys Met Val Thr His 
                645                 650                 655     


Phe Glu Lys Leu Gly Leu Glu Ile Glu Ile Glu Asp Ile Glu Glu Ile 
            660                 665                 670         


Glu Gly Gly Trp Arg Val Thr Phe Lys Arg Val Tyr Pro Glu Ala Thr 
        675                 680                 685             


Arg Glu Ile Arg Asp Leu Ile Gly Gly Lys Ala Phe Val Asp 
    690                 695                 700         


<210>  6
<211>  700
<212>  PRT
<213>  ˹

<220>
<223>  ںø

<400>  6

Met Lys Lys Ile Ile Leu Thr Ile Gly Cys Pro Gly Ser Gly Lys Ser 
1               5                   10                  15      


Thr Trp Ala Arg Glu Phe Ile Ala Lys Asn Pro Gly Phe Tyr Asn Ile 
            20                  25                  30          


Asn Arg Asp Asp Tyr Arg Gln Ser Ile Met Ala His Glu Glu Arg Asp 
        35                  40                  45              


Glu Tyr Lys Tyr Thr Lys Lys Lys Glu Gly Ile Val Thr Gly Met Gln 
    50                  55                  60                  


Phe Asp Thr Ala Lys Ser Ile Leu Tyr Gly Gly Asp Ser Val Lys Gly 
65                  70                  75                  80  


Val Ile Ile Ser Asp Thr Asn Leu Asn Pro Glu Arg Arg Leu Ala Trp 
                85                  90                  95      


Glu Thr Phe Ala Lys Glu Tyr Gly Trp Lys Val Glu His Lys Val Phe 
            100                 105                 110         


Asp Val Pro Trp Thr Glu Leu Val Lys Arg Asn Ser Lys Arg Gly Thr 
        115                 120                 125             


Lys Ala Val Pro Ile Asp Val Leu Arg Ser Met Tyr Lys Ser Met Arg 
    130                 135                 140                 


Glu Tyr Leu Gly Leu Pro Val Tyr Asn Gly Thr Pro Gly Lys Pro Lys 
145                 150                 155                 160 


Ala Val Ile Phe Asp Val Asp Gly Thr Leu Ala Lys Met Asn Gly Arg 
                165                 170                 175     


Gly Pro Tyr Asp Leu Glu Lys Cys Asp Thr Asp Val Ile Asn Pro Met 
            180                 185                 190         


Val Val Glu Leu Ser Lys Met Tyr Ala Leu Met Gly Tyr Gln Ile Val 
        195                 200                 205             


Val Val Ser Gly Arg Glu Ser Gly Thr Lys Glu Asp Pro Thr Lys Tyr 
    210                 215                 220                 


Tyr Arg Met Thr Arg Lys Trp Val Glu Asp Ile Ala Gly Val Pro Leu 
225                 230                 235                 240 


Val Met Gln Cys Gln Arg Glu Gln Gly Asp Thr Arg Lys Asp Asp Val 
                245                 250                 255     


Val Lys Glu Glu Ile Phe Trp Lys His Ile Ala Pro His Phe Asp Val 
            260                 265                 270         


Lys Leu Ala Ile Asp Asp Arg Thr Gln Val Val Glu Met Trp Arg Arg 
        275                 280                 285             


Ile Gly Val Glu Cys Trp Gln Val Ala Ser Gly Asp Ser Ser Gly Gly 
    290                 295                 300                 


Ser Gly Gly Ser Gly Gly Ser Ala Gly Glu Asn Met Val Ser Ser Lys 
305                 310                 315                 320 


Phe Lys Glu Leu Leu Tyr Thr Leu Gly Ile Pro Glu Asp Lys Val Glu 
                325                 330                 335     


Ile Leu Glu Ala Arg Gly Gly Ile Met Glu Asp Glu Phe Glu Gly Ile 
            340                 345                 350         


Arg Tyr Leu Arg Phe Lys Asn Ser Val Gly Lys Leu Arg Arg Gly Thr 
        355                 360                 365             


Val Leu Phe Glu Asp Gly Thr Thr Val Phe Gly Phe Pro His Ile Lys 
    370                 375                 380                 


Arg Ile Val Asn Leu Ser Ala Gly Val Arg Lys Ile Phe Lys Ser Ser 
385                 390                 395                 400 


Glu Phe Tyr Val Glu Glu Lys Val Asp Gly Tyr Asn Val Arg Val Val 
                405                 410                 415     


Lys Phe Lys Asp Arg Ile Leu Gly Ile Thr Arg Gly Gly Phe Ile Cys 
            420                 425                 430         


Pro Tyr Thr Thr Glu Arg Ile Ala Glu Phe Val Pro Glu Glu Phe Phe 
        435                 440                 445             


Lys Asp His Lys Asp Leu Val Leu Val Gly Glu Met Ala Gly Pro Glu 
    450                 455                 460                 


Ser Pro Tyr Leu Val Glu Gly Pro Pro Tyr Val Lys Glu Asp Ile Gln 
465                 470                 475                 480 


Phe Phe Leu Phe Asp Ile Gln Asp Ile Lys Thr Gly Ser Ser Leu Pro 
                485                 490                 495     


Val Glu Glu Arg Leu Lys Leu Ala Glu Glu Tyr Gly Ile Asn His Val 
            500                 505                 510         


Glu Val Phe Gly Arg Tyr Ser Tyr Lys Asp Ile Asp Asp Leu Tyr Glu 
        515                 520                 525             


Leu Ile Glu Arg Leu Ser Arg Glu Gly Arg Glu Gly Ile Val Met Lys 
    530                 535                 540                 


Ser Pro Asp Met Lys Lys Ile Val Lys Tyr Val Thr Pro Tyr Ala Asn 
545                 550                 555                 560 


Ile Asn Asp Ile Lys Ile Gly Ala Arg Val Phe Tyr Glu Leu Pro Gly 
                565                 570                 575     


Gly Tyr Phe Thr Ser Arg Ile Ser Arg Leu Ala Phe Tyr Ile Ala Glu 
            580                 585                 590         


Lys Lys Ile Arg Gly Glu Glu Leu His Asn Leu Ala Leu Gln Leu Gly 
        595                 600                 605             


Lys Ala Leu Leu Gln Pro Leu Val Glu Ala Ile His Asp Val Thr Gln 
    610                 615                 620                 


Gly Asp Val Ile Ala Glu Arg Phe Arg Val Arg Val Arg Lys Ile Glu 
625                 630                 635                 640 


Thr Ala Tyr Lys Met Val Thr His Phe Glu Lys Leu Gly Leu Glu Ile 
                645                 650                 655     


Glu Ile Glu Asp Ile Glu Glu Ile Glu Gly Gly Trp Arg Val Thr Phe 
            660                 665                 670         


Lys Arg Val Tyr Pro Glu Ala Thr Arg Glu Ile Arg Asp Leu Ile Gly 
        675                 680                 685             


Gly Lys Ala Phe Val Asp His His His His His His 
    690                 695                 700 


<210>  7
<211>  58
<212>  DNA
<213>  ˹

<220>
<223>  

<400>  7
agcggtggca gtggcggtag cggtggcagt gcgggtatga agaagataat tctgacca         58


<210>  8
<211>  38
<212>  DNA
<213>  ˹

<220>
<223>  

<400>  8
tggtggtggt gctcgagtta gtcgccgctc gccacctg                               38


<210>  9
<211>  34
<212>  DNA
<213>  ˹

<220>
<223>  

<400>  9
taactcgagc accaccacca ccaccactga gatc                                   34


<210>  10
<211>  46
<212>  DNA
<213>  ˹

<220>
<223>  

<400>  10
ctaccgccac tgccaccgct actatcaaca aaggctttac caccaa                      46


<210>  11
<211>  45
<212>  DNA
<213>  ˹

<220>
<223>  

<400>  11
atcatcatca ccatcatcat aagaagataa ttctgaccat tggct                       45


<210>  12
<211>  57
<212>  DNA
<213>  ˹

<220>
<223>  

<400>  12
acccgcactg ccaccgctac cgccactgcc accgctactg tcgccgctcg ccacctg          57


<210>  13
<211>  47
<212>  DNA
<213>  ˹

<220>
<223>  

<400>  13
gtagcggtgg cagtgcgggt gaaaatatgg tgagtagcaa attcaaa                     47


<210>  14
<211>  35
<212>  DNA
<213>  ˹

<220>
<223>  

<400>  14
atgatgatgg tgatgatgat gatgcatggt atatc                                  35


<210>  15
<211>  47
<212>  DNA
<213>  ˹

<220>
<223>  

<400>  15
gaaggagata ggatccgatg gaaaatatgg tgagtagcaa attcaaa                     47


<210>  16
<211>  59
<212>  DNA
<213>  ˹

<220>
<223>  

<400>  16
acccgcactg ccaccgctac cgccactgcc accgctacta tcaacaaagg ctttaccac        59


<210>  17
<211>  45
<212>  DNA
<213>  ˹

<220>
<223>  

<400>  17
gtagcggtgg cagtgcgggt aagaagataa ttctgaccat tggct                       45


<210>  18
<211>  25
<212>  DNA
<213>  ˹

<220>
<223>  

<400>  18
catcggatcc tatctccttc ttaaa                                             25


<210>  19
<211>  59
<212>  DNA
<213>  ˹

<220>
<223>  

<400>  19
agcggtggca gtggcggtag cggtggcagt gcgggtgaaa atatggtgag tagcaaatt        59


<210>  20
<211>  43
<212>  DNA
<213>  ˹

<220>
<223>  

<400>  20
tagtgatggt ggtgatgatg atcaacaaag gctttaccac caa                         43


<210>  21
<211>  25
<212>  DNA
<213>  ˹

<220>
<223>  

<400>  21
catcatcacc accatcacta actcg                                             25


<210>  22
<211>  41
<212>  DNA
<213>  ˹

<220>
<223>  

<400>  22
ctaccgccac tgccaccgct actgtcgccg ctcgccacct g                           41


<210>  23
<211>  17
<212>  DNA
<213>  ˹

<220>
<223>  oligo

<400>  23
gtgtaggcac catcaat                                                      17


<210>  24
<211>  17
<212>  DNA
<213>  ˹

<220>
<223>  oligo


<220>
<221>  modified_base
<222>  (1)..(1)
<223>  phos

<400>  24
gtgtaggcac catcaat                                                      17


<210>  25
<211>  17
<212>  DNA
<213>  ˹

<220>
<223>  oligo


<220>
<221>  modified_base
<222>  (1)..(1)
<223>  APP

<400>  25
gtgtaggcac catcaat                                                      17


<210>  26
<211>  19
<212>  RNA
<213>  ˹

<220>
<223>  oligo

<400>  26
caguggcugg uugagauuu                                                    19


<210>  27
<211>  55
<212>  DNA
<213>  ˹

<220>
<223>  oligo


<220>
<221>  modified_base
<222>  (1)..(1)
<223>  phos

<400>  27
gtcctcagtc ccaaaagaag cggagcttct tttttttttt tccgtctgaa gagga            55


<210>  28
<211>  12
<212>  DNA
<213>  ˹

<220>
<223>  linker

<400>  28
sggsggsggs ag                                                           12


