                         SEQUENCE LISTING

<110>  WANG, Lai-Xi
       ZHANG, Xiao
 
<120>  SITE-SPECIFIC GLYCAN REMODELING OF LYSOSOMAL ENZYMES AND 
       APPLICATIONS THEREOF

<130>  171351.00039

<150>  63/178,731
<151>  2021-04-23

<150>  63/264,011
<151>  2021-11-12

<160>  27    

<170>  PatentIn version 3.5

<210>  1
<211>  621
<212>  PRT
<213>  Arthrobacter protophormiae

<400>  1

Ser Thr Tyr Asn Gly Pro Leu Ser Ser His Trp Phe Pro Glu Glu Leu 
1               5                   10                  15      


Ala Gln Trp Glu Pro Asp Ser Asp Pro Asp Ala Pro Phe Asn Arg Ser 
            20                  25                  30          


His Val Pro Leu Glu Pro Gly Arg Val Ala Asn Arg Val Asn Ala Asn 
        35                  40                  45              


Ala Asp Lys Asp Ala His Leu Val Ser Leu Ser Ala Leu Asn Arg His 
    50                  55                  60                  


Thr Ser Gly Val Pro Ser Gln Gly Ala Pro Val Phe Tyr Glu Asn Thr 
65                  70                  75                  80  


Phe Ser Tyr Trp His Tyr Thr Asp Leu Met Val Tyr Trp Ala Gly Ser 
                85                  90                  95      


Ala Gly Glu Gly Ile Ile Val Pro Pro Ser Ala Asp Val Ile Asp Ala 
            100                 105                 110         


Ser His Arg Asn Gly Val Pro Ile Leu Gly Asn Val Phe Phe Pro Pro 
        115                 120                 125             


Thr Val Tyr Gly Gly Gln Leu Glu Trp Leu Glu Gln Met Leu Glu Gln 
    130                 135                 140                 


Glu Glu Asp Gly Ser Phe Pro Leu Ala Asp Lys Leu Leu Glu Val Ala 
145                 150                 155                 160 


Asp Tyr Tyr Gly Phe Asp Gly Trp Phe Ile Asn Gln Glu Thr Glu Gly 
                165                 170                 175     


Ala Asp Glu Gly Thr Ala Glu Ala Met Gln Ala Phe Leu Val Tyr Leu 
            180                 185                 190         


Gln Glu Gln Lys Pro Glu Gly Met His Ile Met Trp Tyr Asp Ser Met 
        195                 200                 205             


Ile Asp Thr Gly Ala Ile Ala Trp Gln Asn His Leu Thr Asp Arg Asn 
    210                 215                 220                 


Lys Met Tyr Leu Gln Asn Gly Ser Thr Arg Val Ala Asp Ser Met Phe 
225                 230                 235                 240 


Leu Asn Phe Trp Trp Arg Asp Gln Arg Gln Ser Asn Glu Leu Ala Gln 
                245                 250                 255     


Ala Leu Gly Arg Ser Pro Tyr Asp Leu Tyr Ala Gly Val Asp Val Glu 
            260                 265                 270         


Ala Arg Gly Thr Ser Thr Pro Val Gln Trp Glu Gly Leu Phe Pro Glu 
        275                 280                 285             


Gly Glu Lys Ala His Thr Ser Leu Gly Leu Tyr Arg Pro Asp Trp Ala 
    290                 295                 300                 


Phe Gln Ser Ser Glu Thr Met Glu Ala Phe Tyr Glu Lys Glu Leu Gln 
305                 310                 315                 320 


Phe Trp Val Gly Ser Thr Gly Asn Pro Ala Glu Thr Asp Gly Gln Ser 
                325                 330                 335     


Asn Trp Pro Gly Met Ala His Trp Phe Pro Ala Lys Ser Thr Ala Thr 
            340                 345                 350         


Ser Val Pro Phe Val Thr His Phe Asn Thr Gly Ser Gly Ala Gln Phe 
        355                 360                 365             


Ser Ala Glu Gly Lys Thr Val Ser Glu Gln Glu Trp Asn Asn Arg Ser 
    370                 375                 380                 


Leu Gln Asp Val Leu Pro Thr Trp Arg Trp Ile Gln His Gly Gly Asp 
385                 390                 395                 400 


Leu Glu Ala Thr Phe Ser Trp Glu Glu Ala Phe Glu Gly Gly Ser Ser 
                405                 410                 415     


Leu Gln Trp His Gly Ser Leu Ala Glu Gly Glu His Ala Gln Ile Glu 
            420                 425                 430         


Leu Tyr Gln Thr Glu Leu Pro Ile Ser Glu Gly Thr Ser Leu Thr Trp 
        435                 440                 445             


Thr Phe Lys Ser Glu His Gly Asn Asp Leu Asn Val Gly Phe Arg Leu 
    450                 455                 460                 


Asp Gly Glu Glu Asp Phe Arg Tyr Val Glu Gly Glu Gln Arg Glu Ser 
465                 470                 475                 480 


Ile Asn Gly Trp Thr Gln Trp Thr Leu Pro Leu Asp Ala Phe Ala Gly 
                485                 490                 495     


Gln Thr Ile Thr Gly Leu Ala Phe Ala Ala Glu Gly Asn Glu Thr Gly 
            500                 505                 510         


Leu Ala Glu Phe Tyr Ile Gly Gln Leu Ala Val Gly Ala Asp Ser Glu 
        515                 520                 525             


Lys Pro Ala Ala Pro Asn Val Asn Val Arg Gln Tyr Asp Pro Asp Pro 
    530                 535                 540                 


Ser Gly Ile Gln Leu Val Trp Glu Lys Gln Ser Asn Val His His Tyr 
545                 550                 555                 560 


Arg Val Tyr Lys Glu Thr Lys His Gly Lys Glu Leu Ile Gly Thr Ser 
                565                 570                 575     


Ala Gly Asp Arg Ile Tyr Leu Glu Gly Leu Val Glu Glu Ser Lys Gln 
            580                 585                 590         


Asn Asp Val Arg Leu His Ile Glu Ala Leu Ser Glu Thr Phe Val Pro 
        595                 600                 605             


Ser Asp Ala Arg Met Ile Asp Ile Lys Ser Gly Ser Phe 
    610                 615                 620     


<210>  2
<211>  290
<212>  PRT
<213>  Elizabethkingia meningoseptica

<400>  2

Thr Ala Leu Ala Gly Ser Asn Gly Val Cys Ile Ala Tyr Tyr Ile Thr 
1               5                   10                  15      


Asp Gly Arg Asn Ala Pro Thr Phe Lys Leu Lys Asp Ile Pro Asp Lys 
            20                  25                  30          


Val Asp Met Val Ile Leu Phe Gly Leu Lys Tyr Trp Ser Leu Gln Asp 
        35                  40                  45              


Thr Thr Lys Leu Pro Gly Gly Thr Gly Met Met Gly Ser Phe Lys Ser 
    50                  55                  60                  


Tyr Lys Asp Leu Asp Thr Gln Ile Arg Ser Leu Gln Ser Arg Gly Ile 
65                  70                  75                  80  


Lys Val Leu Gln Asn Ile Asp Asp Asp Val Ser Trp Gln Ser Ser Lys 
                85                  90                  95      


Pro Gly Gly Phe Ala Ser Ala Ala Ala Tyr Gly Asp Ala Ile Lys Ser 
            100                 105                 110         


Ile Val Ile Asp Lys Trp Lys Leu Asp Gly Ile Ser Leu Asp Ile Glu 
        115                 120                 125             


His Ser Gly Ala Lys Pro Asn Pro Ile Pro Thr Phe Pro Gly Tyr Ala 
    130                 135                 140                 


Ala Thr Gly Tyr Asn Gly Trp Tyr Ser Gly Ser Met Ala Ala Thr Pro 
145                 150                 155                 160 


Ala Phe Leu Asn Val Ile Ser Glu Leu Thr Lys Tyr Phe Gly Thr Thr 
                165                 170                 175     


Ala Pro Asn Asn Lys Gln Leu Gln Ile Ala Ser Gly Ile Asp Val Tyr 
            180                 185                 190         


Ala Trp Asn Lys Ile Met Glu Asn Phe Arg Asn Asn Phe Asn Tyr Ile 
        195                 200                 205             


Gln Leu Gln Ser Tyr Gly Ala Asn Val Ser Arg Thr Gln Leu Met Met 
    210                 215                 220                 


Asn Tyr Ala Thr Gly Thr Asn Lys Ile Pro Ala Ser Lys Met Val Phe 
225                 230                 235                 240 


Gly Ala Tyr Ala Glu Gly Gly Thr Asn Gln Ala Asn Asp Val Glu Val 
                245                 250                 255     


Ala Lys Trp Thr Pro Thr Gln Gly Ala Lys Gly Gly Met Met Ile Tyr 
            260                 265                 270         


Thr Tyr Asn Ser Asn Val Ser Tyr Ala Asn Ala Val Arg Asp Ala Val 
        275                 280                 285             


Lys Asn 
    290 


<210>  3
<211>  787
<212>  PRT
<213>  Coprinus cinereus

<400>  3

Met Pro Ile Ala Gly Lys Lys Phe His Pro Arg Ala Leu Pro Glu Phe 
1               5                   10                  15      


Trp Arg Thr Phe Arg Glu Met Asp Glu Trp Arg Ala Thr Gln Thr Gly 
            20                  25                  30          


Pro Gln Ala Arg Pro Ala Glu Gly Ile Leu Lys Tyr Val Pro Arg Lys 
        35                  40                  45              


Ile Arg Pro Ala Asp Ile Ala Gly Lys Gly Arg Leu Leu Val Ser His 
    50                  55                  60                  


Asp Tyr Lys Gly Gly Tyr Val Glu Asp Pro Phe Ser Lys Ser Tyr Ser 
65                  70                  75                  80  


Phe Asn Trp Trp Phe Ser Thr Asp Ser Phe Asn Tyr Phe Ala His His 
                85                  90                  95      


Arg Ile Thr Ile Pro Pro Pro Glu Trp Ile Asn Ala Ala His Arg Gln 
            100                 105                 110         


Gly Val Pro Ile Leu Gly Thr Ile Ile Phe Glu Gly Gly Ser Asp Glu 
        115                 120                 125             


Asp Ile Leu Arg Met Val Ile Gly Lys Thr Pro Gly Ser Thr Ser Asn 
    130                 135                 140                 


Phe His Ala Glu Arg Asn Ala Glu Tyr Thr Val Pro Val Ser Ser Tyr 
145                 150                 155                 160 


Tyr Ala Glu Leu Phe Ala Asp Leu Ala Val Glu Arg Gly Phe Asp Gly 
                165                 170                 175     


Trp Leu Leu Asn Val Glu Ile Gly Leu Gln Gly Gly Ser Glu Gln Ala 
            180                 185                 190         


Arg Gly Leu Ala Ala Trp Val Ala Leu Leu Gln Gln Glu Val Leu Lys 
        195                 200                 205             


Lys Val Gly Pro His Gly Leu Val Ile Trp Tyr Asp Ser Val Thr Val 
    210                 215                 220                 


Arg Gly Asp Leu Trp Trp Gln Asp Arg Leu Asn Ala Phe Asn Leu Pro 
225                 230                 235                 240 


Phe Phe Leu Asn Ser Ser Gly Ile Phe Thr Asn Tyr Trp Trp Tyr Asn 
                245                 250                 255     


Asp Ala Pro Gln Lys Gln Ile Asp Phe Leu Ser Arg Val Asp Pro Asn 
            260                 265                 270         


Leu Thr Gly Gln Thr Ala Glu Pro His Gln Tyr Asn Leu Gln Lys Thr 
        275                 280                 285             


Ile Gln Asp Ile Tyr Ile Gly Val Asp Val Trp Gly Arg Gly Ser His 
    290                 295                 300                 


Gly Gly Gly Gly Phe Gly Ala Tyr Lys Ala Ile Glu His Ala Asp Pro 
305                 310                 315                 320 


Lys Gly Leu Gly Phe Ser Val Ala Leu Phe Ala Gln Gly Trp Thr Trp 
                325                 330                 335     


Glu Thr Glu Glu Glu Lys Pro Gly Trp Asn Trp Ala Gln Phe Trp Asp 
            340                 345                 350         


Tyr Asp Ser Lys Leu Trp Val Gly Pro Pro Gly Val Val Glu Ala Pro 
        355                 360                 365             


Asp His Thr Val Lys Pro Gly Glu Tyr Pro Cys Val His Gly Pro Phe 
    370                 375                 380                 


Gln Pro Ile Ser Ser Phe Phe Leu Thr Tyr Pro Pro Pro Asp Pro Leu 
385                 390                 395                 400 


Asp Leu Pro Phe Tyr Thr Asn Phe Cys Pro Gly Ile Gly Asp Ala Trp 
                405                 410                 415     


Phe Val Glu Gly Lys Glu Val Phe Arg Ser Glu Thr Gly Trp Thr Asp 
            420                 425                 430         


Met Asp Lys Gln Thr Thr Val Gly Asp Leu Val Trp Pro Arg Pro Lys 
        435                 440                 445             


Ile Tyr Asp Leu Pro Ser Gln Asn Ala Ser Gln Ala Thr Leu Asn Ala 
    450                 455                 460                 


Ala Phe Asn Phe Asn Asp Ala Trp Asn Gly Gly Asn Ser Leu Gln Ile 
465                 470                 475                 480 


Asn Leu Thr Val Pro Gly Gly Ala Thr Thr Tyr Gly Ala Tyr Trp Val 
                485                 490                 495     


Pro Ile Gln Thr Phe Thr Phe Ser Ser Arg Arg Gln Tyr Glu Ala Ser 
            500                 505                 510         


Ile Val Tyr Lys Pro Gly Leu Ser Gly Lys Thr Arg Phe Asp Ala Lys 
        515                 520                 525             


Tyr Glu Val Gly Ile Arg Thr Ile Thr Gly Glu Asp Gln Gly Lys Ile 
    530                 535                 540                 


Ile Ser Asn Thr Thr Thr Glu Val Gly Asn Gly Trp Arg Lys Val His 
545                 550                 555                 560 


Ile Leu Phe Glu Ile Glu Thr Pro Val Glu Gly Gly Ser Ile Ile Val 
                565                 570                 575     


Pro Ser Ser Ile Gly Leu Val Ile Ala Val Ser Asn Val Ser Thr Thr 
            580                 585                 590         


Glu Gln Phe Glu Phe Pro Phe Leu Val Gly Gln Ile Thr Ile His Pro 
        595                 600                 605             


His Leu Pro Asp Arg Tyr Lys Glu Phe Lys Pro Ala Leu Leu Trp Leu 
    610                 615                 620                 


Leu Phe Thr Pro Ser Ala Gly Thr Asn Ser Leu Asp Gly Thr Leu Thr 
625                 630                 635                 640 


Trp Asp Val Val Ala Ala Ile Glu Arg Pro Pro Pro Val Glu Ile Asn 
                645                 650                 655     


Asn Pro Asp Asp Ala Gln Ile Pro Trp Asn Leu Gln Pro Thr Lys Gln 
            660                 665                 670         


Glu Trp Phe Pro Asp Phe Leu Tyr Phe Asn Val Tyr Val Leu Glu Leu 
        675                 680                 685             


Leu Asp Gly Gly Gly Gln Gly Pro Pro Gln Trp Ile Gly Thr Thr Gly 
    690                 695                 700                 


Tyr Asp Gly Glu Lys Lys Arg Phe Phe Ile Tyr Asp Glu Ser Leu Pro 
705                 710                 715                 720 


Pro Thr Ser Gly Leu Arg Arg Phe Thr Phe Gln Ile Glu Gly Val Leu 
                725                 730                 735     


Glu Thr Gly Glu Ser Thr His Trp Tyr Asp Ala Pro Ala Ala Pro Ser 
            740                 745                 750         


Ala Thr Ala Gly Gly Glu Gln Lys Arg Thr Arg Arg Thr Ser Leu Lys 
        755                 760                 765             


Ser Val Leu Ser Pro Leu Arg Arg Lys Lys Ser Lys Gly Asp Ile Ser 
    770                 775                 780                 


Val Ala Lys 
785         


<210>  4
<211>  429
<212>  PRT
<213>  Homo sapiens

<400>  4

Met Gln Leu Arg Asn Pro Glu Leu His Leu Gly Cys Ala Leu Ala Leu 
1               5                   10                  15      


Arg Phe Leu Ala Leu Val Ser Trp Asp Ile Pro Gly Ala Arg Ala Leu 
            20                  25                  30          


Asp Asn Gly Leu Ala Arg Thr Pro Thr Met Gly Trp Leu His Trp Glu 
        35                  40                  45              


Arg Phe Met Cys Asn Leu Asp Cys Gln Glu Glu Pro Asp Ser Cys Ile 
    50                  55                  60                  


Ser Glu Lys Leu Phe Met Glu Met Ala Glu Leu Met Val Ser Glu Gly 
65                  70                  75                  80  


Trp Lys Asp Ala Gly Tyr Glu Tyr Leu Cys Ile Asp Asp Cys Trp Met 
                85                  90                  95      


Ala Pro Gln Arg Asp Ser Glu Gly Arg Leu Gln Ala Asp Pro Gln Arg 
            100                 105                 110         


Phe Pro His Gly Ile Arg Gln Leu Ala Asn Tyr Val His Ser Lys Gly 
        115                 120                 125             


Leu Lys Leu Gly Ile Tyr Ala Asp Val Gly Asn Lys Thr Cys Ala Gly 
    130                 135                 140                 


Phe Pro Gly Ser Phe Gly Tyr Tyr Asp Ile Asp Ala Gln Thr Phe Ala 
145                 150                 155                 160 


Asp Trp Gly Val Asp Leu Leu Lys Phe Asp Gly Cys Tyr Cys Asp Ser 
                165                 170                 175     


Leu Glu Asn Leu Ala Asp Gly Tyr Lys His Met Ser Leu Ala Leu Asn 
            180                 185                 190         


Arg Thr Gly Arg Ser Ile Val Tyr Ser Cys Glu Trp Pro Leu Tyr Met 
        195                 200                 205             


Trp Pro Phe Gln Lys Pro Asn Tyr Thr Glu Ile Arg Gln Tyr Cys Asn 
    210                 215                 220                 


His Trp Arg Asn Phe Ala Asp Ile Asp Asp Ser Trp Lys Ser Ile Lys 
225                 230                 235                 240 


Ser Ile Leu Asp Trp Thr Ser Phe Asn Gln Glu Arg Ile Val Asp Val 
                245                 250                 255     


Ala Gly Pro Gly Gly Trp Asn Asp Pro Asp Met Leu Val Ile Gly Asn 
            260                 265                 270         


Phe Gly Leu Ser Trp Asn Gln Gln Val Thr Gln Met Ala Leu Trp Ala 
        275                 280                 285             


Ile Met Ala Ala Pro Leu Phe Met Ser Asn Asp Leu Arg His Ile Ser 
    290                 295                 300                 


Pro Gln Ala Lys Ala Leu Leu Gln Asp Lys Asp Val Ile Ala Ile Asn 
305                 310                 315                 320 


Gln Asp Pro Leu Gly Lys Gln Gly Tyr Gln Leu Arg Gln Gly Asp Asn 
                325                 330                 335     


Phe Glu Val Trp Glu Arg Pro Leu Ser Gly Leu Ala Trp Ala Val Ala 
            340                 345                 350         


Met Ile Asn Arg Gln Glu Ile Gly Gly Pro Arg Ser Tyr Thr Ile Ala 
        355                 360                 365             


Val Ala Ser Leu Gly Lys Gly Val Ala Cys Asn Pro Ala Cys Phe Ile 
    370                 375                 380                 


Thr Gln Leu Leu Pro Val Lys Arg Lys Leu Gly Phe Tyr Glu Trp Thr 
385                 390                 395                 400 


Ser Arg Leu Arg Ser His Ile Asn Pro Thr Gly Thr Val Leu Leu Gln 
                405                 410                 415     


Leu Glu Asn Thr Met Gln Met Ser Leu Lys Asp Leu Leu 
            420                 425                 


<210>  5
<211>  395
<212>  PRT
<213>  Homo sapiens

<400>  5

Met Pro Gly Arg Ser Cys Val Ala Leu Val Leu Leu Ala Ala Ala Val 
1               5                   10                  15      


Ser Cys Ala Val Ala Gln His Ala Pro Pro Trp Thr Glu Asp Cys Arg 
            20                  25                  30          


Lys Ser Thr Tyr Pro Pro Ser Gly Pro Thr Tyr Arg Gly Ala Val Pro 
        35                  40                  45              


Trp Tyr Thr Ile Asn Leu Asp Leu Pro Pro Tyr Lys Arg Trp His Glu 
    50                  55                  60                  


Leu Met Leu Asp Lys Ala Pro Val Leu Lys Val Ile Val Asn Ser Leu 
65                  70                  75                  80  


Lys Asn Met Ile Asn Thr Phe Val Pro Ser Gly Lys Ile Met Gln Val 
                85                  90                  95      


Val Asp Glu Lys Leu Pro Gly Leu Leu Gly Asn Phe Pro Gly Pro Phe 
            100                 105                 110         


Glu Glu Glu Met Lys Gly Ile Ala Ala Val Thr Asp Ile Pro Leu Gly 
        115                 120                 125             


Glu Ile Ile Ser Phe Asn Ile Phe Tyr Glu Leu Phe Thr Ile Cys Thr 
    130                 135                 140                 


Ser Ile Val Ala Glu Asp Lys Lys Gly His Leu Ile His Gly Arg Asn 
145                 150                 155                 160 


Met Asp Phe Gly Val Phe Leu Gly Trp Asn Ile Asn Asn Asp Thr Trp 
                165                 170                 175     


Val Ile Thr Glu Gln Leu Lys Pro Leu Thr Val Asn Leu Asp Phe Gln 
            180                 185                 190         


Arg Asn Asn Lys Thr Val Phe Lys Ala Ser Ser Phe Ala Gly Tyr Val 
        195                 200                 205             


Gly Met Leu Thr Gly Phe Lys Pro Gly Leu Phe Ser Leu Thr Leu Asn 
    210                 215                 220                 


Glu Arg Phe Ser Ile Asn Gly Gly Tyr Leu Gly Ile Leu Glu Trp Ile 
225                 230                 235                 240 


Leu Gly Lys Lys Asp Val Met Trp Ile Gly Phe Leu Thr Arg Thr Val 
                245                 250                 255     


Leu Glu Asn Ser Thr Ser Tyr Glu Glu Ala Lys Asn Leu Leu Thr Lys 
            260                 265                 270         


Thr Lys Ile Leu Ala Pro Ala Tyr Phe Ile Leu Gly Gly Asn Gln Ser 
        275                 280                 285             


Gly Glu Gly Cys Val Ile Thr Arg Asp Arg Lys Glu Ser Leu Asp Val 
    290                 295                 300                 


Tyr Glu Leu Asp Ala Lys Gln Gly Arg Trp Tyr Val Val Gln Thr Asn 
305                 310                 315                 320 


Tyr Asp Arg Trp Lys His Pro Phe Phe Leu Asp Asp Arg Arg Thr Pro 
                325                 330                 335     


Ala Lys Met Cys Leu Asn Arg Thr Ser Gln Glu Asn Ile Ser Phe Glu 
            340                 345                 350         


Thr Met Tyr Asp Val Leu Ser Thr Lys Pro Val Leu Asn Lys Leu Thr 
        355                 360                 365             


Val Tyr Thr Thr Leu Ile Asp Val Thr Lys Gly Gln Phe Glu Thr Tyr 
    370                 375                 380                 


Leu Arg Asp Cys Pro Asp Pro Cys Ile Gly Trp 
385                 390                 395 


<210>  6
<211>  466
<212>  PRT
<213>  Homo sapiens

<400>  6

Met Arg Ala Pro Gly Met Arg Ser Arg Pro Ala Gly Pro Ala Leu Leu 
1               5                   10                  15      


Leu Leu Leu Leu Phe Leu Gly Ala Ala Glu Ser Val Arg Arg Ala Gln 
            20                  25                  30          


Pro Pro Arg Arg Tyr Thr Pro Asp Trp Pro Ser Leu Asp Ser Arg Pro 
        35                  40                  45              


Leu Pro Ala Trp Phe Asp Glu Ala Lys Phe Gly Val Phe Ile His Trp 
    50                  55                  60                  


Gly Val Phe Ser Val Pro Ala Trp Gly Ser Glu Trp Phe Trp Trp His 
65                  70                  75                  80  


Trp Gln Gly Glu Gly Arg Pro Gln Tyr Gln Arg Phe Met Arg Asp Asn 
                85                  90                  95      


Tyr Pro Pro Gly Phe Ser Tyr Ala Asp Phe Gly Pro Gln Phe Thr Ala 
            100                 105                 110         


Arg Phe Phe His Pro Glu Glu Trp Ala Asp Leu Phe Gln Ala Ala Gly 
        115                 120                 125             


Ala Lys Tyr Val Val Leu Thr Thr Lys His His Glu Gly Phe Thr Asn 
    130                 135                 140                 


Trp Pro Ser Pro Val Ser Trp Asn Trp Asn Ser Lys Asp Val Gly Pro 
145                 150                 155                 160 


His Arg Asp Leu Val Gly Glu Leu Gly Thr Ala Leu Arg Lys Arg Asn 
                165                 170                 175     


Ile Arg Tyr Gly Leu Tyr His Ser Leu Leu Glu Trp Phe His Pro Leu 
            180                 185                 190         


Tyr Leu Leu Asp Lys Lys Asn Gly Phe Lys Thr Gln His Phe Val Ser 
        195                 200                 205             


Ala Lys Thr Met Pro Glu Leu Tyr Asp Leu Val Asn Ser Tyr Lys Pro 
    210                 215                 220                 


Asp Leu Ile Trp Ser Asp Gly Glu Trp Glu Cys Pro Asp Thr Tyr Trp 
225                 230                 235                 240 


Asn Ser Thr Asn Phe Leu Ser Trp Leu Tyr Asn Asp Ser Pro Val Lys 
                245                 250                 255     


Asp Glu Val Val Val Asn Asp Arg Trp Gly Gln Asn Cys Ser Cys His 
            260                 265                 270         


His Gly Gly Tyr Tyr Asn Cys Glu Asp Lys Phe Lys Pro Gln Ser Leu 
        275                 280                 285             


Pro Asp His Lys Trp Glu Met Cys Thr Ser Ile Asp Lys Phe Ser Trp 
    290                 295                 300                 


Gly Tyr Arg Arg Asp Met Ala Leu Ser Asp Val Thr Glu Glu Ser Glu 
305                 310                 315                 320 


Ile Ile Ser Glu Leu Val Gln Thr Val Ser Leu Gly Gly Asn Tyr Leu 
                325                 330                 335     


Leu Asn Ile Gly Pro Thr Lys Asp Gly Leu Ile Val Pro Ile Phe Gln 
            340                 345                 350         


Glu Arg Leu Leu Ala Val Gly Lys Trp Leu Ser Ile Asn Gly Glu Ala 
        355                 360                 365             


Ile Tyr Ala Ser Lys Pro Trp Arg Val Gln Trp Glu Lys Asn Thr Thr 
    370                 375                 380                 


Ser Val Trp Tyr Thr Ser Lys Gly Ser Ala Val Tyr Ala Ile Phe Leu 
385                 390                 395                 400 


His Trp Pro Glu Asn Gly Val Leu Asn Leu Glu Ser Pro Ile Thr Thr 
                405                 410                 415     


Ser Thr Thr Lys Ile Thr Met Leu Gly Ile Gln Gly Asp Leu Lys Trp 
            420                 425                 430         


Ser Thr Asp Pro Asp Lys Gly Leu Phe Ile Ser Leu Pro Gln Leu Pro 
        435                 440                 445             


Pro Ser Ala Val Pro Ala Glu Phe Ala Trp Thr Ile Lys Leu Thr Gly 
    450                 455                 460                 


Val Lys 
465     


<210>  7
<211>  536
<212>  PRT
<213>  Homo sapiens

<400>  7

Met Glu Phe Ser Ser Pro Ser Arg Glu Glu Cys Pro Lys Pro Leu Ser 
1               5                   10                  15      


Arg Val Ser Ile Met Ala Gly Ser Leu Thr Gly Leu Leu Leu Leu Gln 
            20                  25                  30          


Ala Val Ser Trp Ala Ser Gly Ala Arg Pro Cys Ile Pro Lys Ser Phe 
        35                  40                  45              


Gly Tyr Ser Ser Val Val Cys Val Cys Asn Ala Thr Tyr Cys Asp Ser 
    50                  55                  60                  


Phe Asp Pro Pro Thr Phe Pro Ala Leu Gly Thr Phe Ser Arg Tyr Glu 
65                  70                  75                  80  


Ser Thr Arg Ser Gly Arg Arg Met Glu Leu Ser Met Gly Pro Ile Gln 
                85                  90                  95      


Ala Asn His Thr Gly Thr Gly Leu Leu Leu Thr Leu Gln Pro Glu Gln 
            100                 105                 110         


Lys Phe Gln Lys Val Lys Gly Phe Gly Gly Ala Met Thr Asp Ala Ala 
        115                 120                 125             


Ala Leu Asn Ile Leu Ala Leu Ser Pro Pro Ala Gln Asn Leu Leu Leu 
    130                 135                 140                 


Lys Ser Tyr Phe Ser Glu Glu Gly Ile Gly Tyr Asn Ile Ile Arg Val 
145                 150                 155                 160 


Pro Met Ala Ser Cys Asp Phe Ser Ile Arg Thr Tyr Thr Tyr Ala Asp 
                165                 170                 175     


Thr Pro Asp Asp Phe Gln Leu His Asn Phe Ser Leu Pro Glu Glu Asp 
            180                 185                 190         


Thr Lys Leu Lys Ile Pro Leu Ile His Arg Ala Leu Gln Leu Ala Gln 
        195                 200                 205             


Arg Pro Val Ser Leu Leu Ala Ser Pro Trp Thr Ser Pro Thr Trp Leu 
    210                 215                 220                 


Lys Thr Asn Gly Ala Val Asn Gly Lys Gly Ser Leu Lys Gly Gln Pro 
225                 230                 235                 240 


Gly Asp Ile Tyr His Gln Thr Trp Ala Arg Tyr Phe Val Lys Phe Leu 
                245                 250                 255     


Asp Ala Tyr Ala Glu His Lys Leu Gln Phe Trp Ala Val Thr Ala Glu 
            260                 265                 270         


Asn Glu Pro Ser Ala Gly Leu Leu Ser Gly Tyr Pro Phe Gln Cys Leu 
        275                 280                 285             


Gly Phe Thr Pro Glu His Gln Arg Asp Phe Ile Ala Arg Asp Leu Gly 
    290                 295                 300                 


Pro Thr Leu Ala Asn Ser Thr His His Asn Val Arg Leu Leu Met Leu 
305                 310                 315                 320 


Asp Asp Gln Arg Leu Leu Leu Pro His Trp Ala Lys Val Val Leu Thr 
                325                 330                 335     


Asp Pro Glu Ala Ala Lys Tyr Val His Gly Ile Ala Val His Trp Tyr 
            340                 345                 350         


Leu Asp Phe Leu Ala Pro Ala Lys Ala Thr Leu Gly Glu Thr His Arg 
        355                 360                 365             


Leu Phe Pro Asn Thr Met Leu Phe Ala Ser Glu Ala Cys Val Gly Ser 
    370                 375                 380                 


Lys Phe Trp Glu Gln Ser Val Arg Leu Gly Ser Trp Asp Arg Gly Met 
385                 390                 395                 400 


Gln Tyr Ser His Ser Ile Ile Thr Asn Leu Leu Tyr His Val Val Gly 
                405                 410                 415     


Trp Thr Asp Trp Asn Leu Ala Leu Asn Pro Glu Gly Gly Pro Asn Trp 
            420                 425                 430         


Val Arg Asn Phe Val Asp Ser Pro Ile Ile Val Asp Ile Thr Lys Asp 
        435                 440                 445             


Thr Phe Tyr Lys Gln Pro Met Phe Tyr His Leu Gly His Phe Ser Lys 
    450                 455                 460                 


Phe Ile Pro Glu Gly Ser Gln Arg Val Gly Leu Val Ala Ser Gln Lys 
465                 470                 475                 480 


Asn Asp Leu Asp Ala Val Ala Leu Met His Pro Asp Gly Ser Ala Val 
                485                 490                 495     


Val Val Val Leu Asn Arg Ser Ser Lys Asp Val Pro Leu Thr Ile Lys 
            500                 505                 510         


Asp Pro Ala Val Gly Phe Leu Glu Thr Ile Ser Pro Gly Tyr Ser Ile 
        515                 520                 525             


His Thr Tyr Leu Trp Arg Arg Gln 
    530                 535     


<210>  8
<211>  677
<212>  PRT
<213>  Homo sapiens

<400>  8

Met Pro Gly Phe Leu Val Arg Ile Leu Pro Leu Leu Leu Val Leu Leu 
1               5                   10                  15      


Leu Leu Gly Pro Thr Arg Gly Leu Arg Asn Ala Thr Gln Arg Met Phe 
            20                  25                  30          


Glu Ile Asp Tyr Ser Arg Asp Ser Phe Leu Lys Asp Gly Gln Pro Phe 
        35                  40                  45              


Arg Tyr Ile Ser Gly Ser Ile His Tyr Ser Arg Val Pro Arg Phe Tyr 
    50                  55                  60                  


Trp Lys Asp Arg Leu Leu Lys Met Lys Met Ala Gly Leu Asn Ala Ile 
65                  70                  75                  80  


Gln Thr Tyr Val Pro Trp Asn Phe His Glu Pro Trp Pro Gly Gln Tyr 
                85                  90                  95      


Gln Phe Ser Glu Asp His Asp Val Glu Tyr Phe Leu Arg Leu Ala His 
            100                 105                 110         


Glu Leu Gly Leu Leu Val Ile Leu Arg Pro Gly Pro Tyr Ile Cys Ala 
        115                 120                 125             


Glu Trp Glu Met Gly Gly Leu Pro Ala Trp Leu Leu Glu Lys Glu Ser 
    130                 135                 140                 


Ile Leu Leu Arg Ser Ser Asp Pro Asp Tyr Leu Ala Ala Val Asp Lys 
145                 150                 155                 160 


Trp Leu Gly Val Leu Leu Pro Lys Met Lys Pro Leu Leu Tyr Gln Asn 
                165                 170                 175     


Gly Gly Pro Val Ile Thr Val Gln Val Glu Asn Glu Tyr Gly Ser Tyr 
            180                 185                 190         


Phe Ala Cys Asp Phe Asp Tyr Leu Arg Phe Leu Gln Lys Arg Phe Arg 
        195                 200                 205             


His His Leu Gly Asp Asp Val Val Leu Phe Thr Thr Asp Gly Ala His 
    210                 215                 220                 


Lys Thr Phe Leu Lys Cys Gly Ala Leu Gln Gly Leu Tyr Thr Thr Val 
225                 230                 235                 240 


Asp Phe Gly Thr Gly Ser Asn Ile Thr Asp Ala Phe Leu Ser Gln Arg 
                245                 250                 255     


Lys Cys Glu Pro Lys Gly Pro Leu Ile Asn Ser Glu Phe Tyr Thr Gly 
            260                 265                 270         


Trp Leu Asp His Trp Gly Gln Pro His Ser Thr Ile Lys Thr Glu Ala 
        275                 280                 285             


Val Ala Ser Ser Leu Tyr Asp Ile Leu Ala Arg Gly Ala Ser Val Asn 
    290                 295                 300                 


Leu Tyr Met Phe Ile Gly Gly Thr Asn Phe Ala Tyr Trp Asn Gly Ala 
305                 310                 315                 320 


Asn Ser Pro Tyr Ala Ala Gln Pro Thr Ser Tyr Asp Tyr Asp Ala Pro 
                325                 330                 335     


Leu Ser Glu Ala Gly Asp Leu Thr Glu Lys Tyr Phe Ala Leu Arg Asn 
            340                 345                 350         


Ile Ile Gln Lys Phe Glu Lys Val Pro Glu Gly Pro Ile Pro Pro Ser 
        355                 360                 365             


Thr Pro Lys Phe Ala Tyr Gly Lys Val Thr Leu Glu Lys Leu Lys Thr 
    370                 375                 380                 


Val Gly Ala Ala Leu Asp Ile Leu Cys Pro Ser Gly Pro Ile Lys Ser 
385                 390                 395                 400 


Leu Tyr Pro Leu Thr Phe Ile Gln Val Lys Gln His Tyr Gly Phe Val 
                405                 410                 415     


Leu Tyr Arg Thr Thr Leu Pro Gln Asp Cys Ser Asn Pro Ala Pro Leu 
            420                 425                 430         


Ser Ser Pro Leu Asn Gly Val His Asp Arg Ala Tyr Val Ala Val Asp 
        435                 440                 445             


Gly Ile Pro Gln Gly Val Leu Glu Arg Asn Asn Val Ile Thr Leu Asn 
    450                 455                 460                 


Ile Thr Gly Lys Ala Gly Ala Thr Leu Asp Leu Leu Val Glu Asn Met 
465                 470                 475                 480 


Gly Arg Val Asn Tyr Gly Ala Tyr Ile Asn Asp Phe Lys Gly Leu Val 
                485                 490                 495     


Ser Asn Leu Thr Leu Ser Ser Asn Ile Leu Thr Asp Trp Thr Ile Phe 
            500                 505                 510         


Pro Leu Asp Thr Glu Asp Ala Val Arg Ser His Leu Gly Gly Trp Gly 
        515                 520                 525             


His Arg Asp Ser Gly His His Asp Glu Ala Trp Ala His Asn Ser Ser 
    530                 535                 540                 


Asn Tyr Thr Leu Pro Ala Phe Tyr Met Gly Asn Phe Ser Ile Pro Ser 
545                 550                 555                 560 


Gly Ile Pro Asp Leu Pro Gln Asp Thr Phe Ile Gln Phe Pro Gly Trp 
                565                 570                 575     


Thr Lys Gly Gln Val Trp Ile Asn Gly Phe Asn Leu Gly Arg Tyr Trp 
            580                 585                 590         


Pro Ala Arg Gly Pro Gln Leu Thr Leu Phe Val Pro Gln His Ile Leu 
        595                 600                 605             


Met Thr Ser Ala Pro Asn Thr Ile Thr Val Leu Glu Leu Glu Trp Ala 
    610                 615                 620                 


Pro Cys Ser Ser Asp Asp Pro Glu Leu Cys Ala Val Thr Phe Val Asp 
625                 630                 635                 640 


Arg Pro Val Ile Gly Ser Ser Val Thr Tyr Asp His Pro Ser Lys Pro 
                645                 650                 655     


Val Glu Lys Arg Leu Met Pro Pro Pro Pro Gln Lys Asn Lys Asp Ser 
            660                 665                 670         


Trp Leu Asp His Val 
        675         


<210>  9
<211>  550
<212>  PRT
<213>  Homo sapiens

<400>  9

Met Pro Pro Pro Arg Thr Gly Arg Gly Leu Leu Trp Leu Gly Leu Val 
1               5                   10                  15      


Leu Ser Ser Val Cys Val Ala Leu Gly Ser Glu Thr Gln Ala Asn Ser 
            20                  25                  30          


Thr Thr Asp Ala Leu Asn Val Leu Leu Ile Ile Val Asp Asp Leu Arg 
        35                  40                  45              


Pro Ser Leu Gly Cys Tyr Gly Asp Lys Leu Val Arg Ser Pro Asn Ile 
    50                  55                  60                  


Asp Gln Leu Ala Ser His Ser Leu Leu Phe Gln Asn Ala Phe Ala Gln 
65                  70                  75                  80  


Gln Ala Val Cys Ala Pro Ser Arg Val Ser Phe Leu Thr Gly Arg Arg 
                85                  90                  95      


Pro Asp Thr Thr Arg Leu Tyr Asp Phe Asn Ser Tyr Trp Arg Val His 
            100                 105                 110         


Ala Gly Asn Phe Ser Thr Ile Pro Gln Tyr Phe Lys Glu Asn Gly Tyr 
        115                 120                 125             


Val Thr Met Ser Val Gly Lys Val Phe His Pro Gly Ile Ser Ser Asn 
    130                 135                 140                 


His Thr Asp Asp Ser Pro Tyr Ser Trp Ser Phe Pro Pro Tyr His Pro 
145                 150                 155                 160 


Ser Ser Glu Lys Tyr Glu Asn Thr Lys Thr Cys Arg Gly Pro Asp Gly 
                165                 170                 175     


Glu Leu His Ala Asn Leu Leu Cys Pro Val Asp Val Leu Asp Val Pro 
            180                 185                 190         


Glu Gly Thr Leu Pro Asp Lys Gln Ser Thr Glu Gln Ala Ile Gln Leu 
        195                 200                 205             


Leu Glu Lys Met Lys Thr Ser Ala Ser Pro Phe Phe Leu Ala Val Gly 
    210                 215                 220                 


Tyr His Lys Pro His Ile Pro Phe Arg Tyr Pro Lys Glu Phe Gln Lys 
225                 230                 235                 240 


Leu Tyr Pro Leu Glu Asn Ile Thr Leu Ala Pro Asp Pro Glu Val Pro 
                245                 250                 255     


Asp Gly Leu Pro Pro Val Ala Tyr Asn Pro Trp Met Asp Ile Arg Gln 
            260                 265                 270         


Arg Glu Asp Val Gln Ala Leu Asn Ile Ser Val Pro Tyr Gly Pro Ile 
        275                 280                 285             


Pro Val Asp Phe Gln Arg Lys Ile Arg Gln Ser Tyr Phe Ala Ser Val 
    290                 295                 300                 


Ser Tyr Leu Asp Thr Gln Val Gly Arg Leu Leu Ser Ala Leu Asp Asp 
305                 310                 315                 320 


Leu Gln Leu Ala Asn Ser Thr Ile Ile Ala Phe Thr Ser Asp His Gly 
                325                 330                 335     


Trp Ala Leu Gly Glu His Gly Glu Trp Ala Lys Tyr Ser Asn Phe Asp 
            340                 345                 350         


Val Ala Thr His Val Pro Leu Ile Phe Tyr Val Pro Gly Arg Thr Ala 
        355                 360                 365             


Ser Leu Pro Glu Ala Gly Glu Lys Leu Phe Pro Tyr Leu Asp Pro Phe 
    370                 375                 380                 


Asp Ser Ala Ser Gln Leu Met Glu Pro Gly Arg Gln Ser Met Asp Leu 
385                 390                 395                 400 


Val Glu Leu Val Ser Leu Phe Pro Thr Leu Ala Gly Leu Ala Gly Leu 
                405                 410                 415     


Gln Val Pro Pro Arg Cys Pro Val Pro Ser Phe His Val Glu Leu Cys 
            420                 425                 430         


Arg Glu Gly Lys Asn Leu Leu Lys His Phe Arg Phe Arg Asp Leu Glu 
        435                 440                 445             


Glu Asp Pro Tyr Leu Pro Gly Asn Pro Arg Glu Leu Ile Ala Tyr Ser 
    450                 455                 460                 


Gln Tyr Pro Arg Pro Ser Asp Ile Pro Gln Trp Asn Ser Asp Lys Pro 
465                 470                 475                 480 


Ser Leu Lys Asp Ile Lys Ile Met Gly Tyr Ser Ile Arg Thr Ile Asp 
                485                 490                 495     


Tyr Arg Tyr Thr Val Trp Val Gly Phe Asn Pro Asp Glu Phe Leu Ala 
            500                 505                 510         


Asn Phe Ser Asp Ile His Ala Gly Glu Leu Tyr Phe Val Asp Ser Asp 
        515                 520                 525             


Pro Leu Gln Asp His Asn Met Tyr Asn Asp Ser Gln Gly Gly Asp Leu 
    530                 535                 540                 


Phe Gln Leu Leu Met Pro 
545                 550 


<210>  10
<211>  653
<212>  PRT
<213>  Homo sapiens

<400>  10

Met Arg Pro Leu Arg Pro Arg Ala Ala Leu Leu Ala Leu Leu Ala Ser 
1               5                   10                  15      


Leu Leu Ala Ala Pro Pro Val Ala Pro Ala Glu Ala Pro His Leu Val 
            20                  25                  30          


His Val Asp Ala Ala Arg Ala Leu Trp Pro Leu Arg Arg Phe Trp Arg 
        35                  40                  45              


Ser Thr Gly Phe Cys Pro Pro Leu Pro His Ser Gln Ala Asp Gln Tyr 
    50                  55                  60                  


Val Leu Ser Trp Asp Gln Gln Leu Asn Leu Ala Tyr Val Gly Ala Val 
65                  70                  75                  80  


Pro His Arg Gly Ile Lys Gln Val Arg Thr His Trp Leu Leu Glu Leu 
                85                  90                  95      


Val Thr Thr Arg Gly Ser Thr Gly Arg Gly Leu Ser Tyr Asn Phe Thr 
            100                 105                 110         


His Leu Asp Gly Tyr Leu Asp Leu Leu Arg Glu Asn Gln Leu Leu Pro 
        115                 120                 125             


Gly Phe Glu Leu Met Gly Ser Ala Ser Gly His Phe Thr Asp Phe Glu 
    130                 135                 140                 


Asp Lys Gln Gln Val Phe Glu Trp Lys Asp Leu Val Ser Ser Leu Ala 
145                 150                 155                 160 


Arg Arg Tyr Ile Gly Arg Tyr Gly Leu Ala His Val Ser Lys Trp Asn 
                165                 170                 175     


Phe Glu Thr Trp Asn Glu Pro Asp His His Asp Phe Asp Asn Val Ser 
            180                 185                 190         


Met Thr Met Gln Gly Phe Leu Asn Tyr Tyr Asp Ala Cys Ser Glu Gly 
        195                 200                 205             


Leu Arg Ala Ala Ser Pro Ala Leu Arg Leu Gly Gly Pro Gly Asp Ser 
    210                 215                 220                 


Phe His Thr Pro Pro Arg Ser Pro Leu Ser Trp Gly Leu Leu Arg His 
225                 230                 235                 240 


Cys His Asp Gly Thr Asn Phe Phe Thr Gly Glu Ala Gly Val Arg Leu 
                245                 250                 255     


Asp Tyr Ile Ser Leu His Arg Lys Gly Ala Arg Ser Ser Ile Ser Ile 
            260                 265                 270         


Leu Glu Gln Glu Lys Val Val Ala Gln Gln Ile Arg Gln Leu Phe Pro 
        275                 280                 285             


Lys Phe Ala Asp Thr Pro Ile Tyr Asn Asp Glu Ala Asp Pro Leu Val 
    290                 295                 300                 


Gly Trp Ser Leu Pro Gln Pro Trp Arg Ala Asp Val Thr Tyr Ala Ala 
305                 310                 315                 320 


Met Val Val Lys Val Ile Ala Gln His Gln Asn Leu Leu Leu Ala Asn 
                325                 330                 335     


Thr Thr Ser Ala Phe Pro Tyr Ala Leu Leu Ser Asn Asp Asn Ala Phe 
            340                 345                 350         


Leu Ser Tyr His Pro His Pro Phe Ala Gln Arg Thr Leu Thr Ala Arg 
        355                 360                 365             


Phe Gln Val Asn Asn Thr Arg Pro Pro His Val Gln Leu Leu Arg Lys 
    370                 375                 380                 


Pro Val Leu Thr Ala Met Gly Leu Leu Ala Leu Leu Asp Glu Glu Gln 
385                 390                 395                 400 


Leu Trp Ala Glu Val Ser Gln Ala Gly Thr Val Leu Asp Ser Asn His 
                405                 410                 415     


Thr Val Gly Val Leu Ala Ser Ala His Arg Pro Gln Gly Pro Ala Asp 
            420                 425                 430         


Ala Trp Arg Ala Ala Val Leu Ile Tyr Ala Ser Asp Asp Thr Arg Ala 
        435                 440                 445             


His Pro Asn Arg Ser Val Ala Val Thr Leu Arg Leu Arg Gly Val Pro 
    450                 455                 460                 


Pro Gly Pro Gly Leu Val Tyr Val Thr Arg Tyr Leu Asp Asn Gly Leu 
465                 470                 475                 480 


Cys Ser Pro Asp Gly Glu Trp Arg Arg Leu Gly Arg Pro Val Phe Pro 
                485                 490                 495     


Thr Ala Glu Gln Phe Arg Arg Met Arg Ala Ala Glu Asp Pro Val Ala 
            500                 505                 510         


Ala Ala Pro Arg Pro Leu Pro Ala Gly Gly Arg Leu Thr Leu Arg Pro 
        515                 520                 525             


Ala Leu Arg Leu Pro Ser Leu Leu Leu Val His Val Cys Ala Arg Pro 
    530                 535                 540                 


Glu Lys Pro Pro Gly Gln Val Thr Arg Leu Arg Ala Leu Pro Leu Thr 
545                 550                 555                 560 


Gln Gly Gln Leu Val Leu Val Trp Ser Asp Glu His Val Gly Ser Lys 
                565                 570                 575     


Cys Leu Trp Thr Tyr Glu Ile Gln Phe Ser Gln Asp Gly Lys Ala Tyr 
            580                 585                 590         


Thr Pro Val Ser Arg Lys Pro Ser Thr Phe Asn Leu Phe Val Phe Ser 
        595                 600                 605             


Pro Asp Thr Gly Ala Val Ser Gly Ser Tyr Arg Val Arg Ala Leu Asp 
    610                 615                 620                 


Tyr Trp Ala Arg Pro Gly Pro Phe Ser Asp Pro Val Pro Tyr Leu Glu 
625                 630                 635                 640 


Val Pro Val Pro Arg Gly Pro Pro Ser Pro Gly Asn Pro 
                645                 650             


<210>  11
<211>  685
<212>  PRT
<213>  Homo sapiens

<400>  11

Met Ala Glu Trp Leu Leu Ser Ala Ser Trp Gln Arg Arg Ala Lys Ala 
1               5                   10                  15      


Met Thr Ala Ala Ala Gly Ser Ala Gly Arg Ala Ala Val Pro Leu Leu 
            20                  25                  30          


Leu Cys Ala Leu Leu Ala Pro Gly Gly Ala Tyr Val Leu Asp Asp Ser 
        35                  40                  45              


Asp Gly Leu Gly Arg Glu Phe Asp Gly Ile Gly Ala Val Ser Gly Gly 
    50                  55                  60                  


Gly Ala Thr Ser Arg Leu Leu Val Asn Tyr Pro Glu Pro Tyr Arg Ser 
65                  70                  75                  80  


Gln Ile Leu Asp Tyr Leu Phe Lys Pro Asn Phe Gly Ala Ser Leu His 
                85                  90                  95      


Ile Leu Lys Val Glu Ile Gly Gly Asp Gly Gln Thr Thr Asp Gly Thr 
            100                 105                 110         


Glu Pro Ser His Met His Tyr Ala Leu Asp Glu Asn Tyr Phe Arg Gly 
        115                 120                 125             


Tyr Glu Trp Trp Leu Met Lys Glu Ala Lys Lys Arg Asn Pro Asn Ile 
    130                 135                 140                 


Thr Leu Ile Gly Leu Pro Trp Ser Phe Pro Gly Trp Leu Gly Lys Gly 
145                 150                 155                 160 


Phe Asp Trp Pro Tyr Val Asn Leu Gln Leu Thr Ala Tyr Tyr Val Val 
                165                 170                 175     


Thr Trp Ile Val Gly Ala Lys Arg Tyr His Asp Leu Asp Ile Asp Tyr 
            180                 185                 190         


Ile Gly Ile Trp Asn Glu Arg Ser Tyr Asn Ala Asn Tyr Ile Lys Ile 
        195                 200                 205             


Leu Arg Lys Met Leu Asn Tyr Gln Gly Leu Gln Arg Val Lys Ile Ile 
    210                 215                 220                 


Ala Ser Asp Asn Leu Trp Glu Ser Ile Ser Ala Ser Met Leu Leu Asp 
225                 230                 235                 240 


Ala Glu Leu Phe Lys Val Val Asp Val Ile Gly Ala His Tyr Pro Gly 
                245                 250                 255     


Thr His Ser Ala Lys Asp Ala Lys Leu Thr Gly Lys Lys Leu Trp Ser 
            260                 265                 270         


Ser Glu Asp Phe Ser Thr Leu Asn Ser Asp Met Gly Ala Gly Cys Trp 
        275                 280                 285             


Gly Arg Ile Leu Asn Gln Asn Tyr Ile Asn Gly Tyr Met Thr Ser Thr 
    290                 295                 300                 


Ile Ala Trp Asn Leu Val Ala Ser Tyr Tyr Glu Gln Leu Pro Tyr Gly 
305                 310                 315                 320 


Arg Cys Gly Leu Met Thr Ala Gln Glu Pro Trp Ser Gly His Tyr Val 
                325                 330                 335     


Val Glu Ser Pro Val Trp Val Ser Ala His Thr Thr Gln Phe Thr Gln 
            340                 345                 350         


Pro Gly Trp Tyr Tyr Leu Lys Thr Val Gly His Leu Glu Lys Gly Gly 
        355                 360                 365             


Ser Tyr Val Ala Leu Thr Asp Gly Leu Gly Asn Leu Thr Ile Ile Ile 
    370                 375                 380                 


Glu Thr Met Ser His Lys His Ser Lys Cys Ile Arg Pro Phe Leu Pro 
385                 390                 395                 400 


Tyr Phe Asn Val Ser Gln Gln Phe Ala Thr Phe Val Leu Lys Gly Ser 
                405                 410                 415     


Phe Ser Glu Ile Pro Glu Leu Gln Val Trp Tyr Thr Lys Leu Gly Lys 
            420                 425                 430         


Thr Ser Glu Arg Phe Leu Phe Lys Gln Leu Asp Ser Leu Trp Leu Leu 
        435                 440                 445             


Asp Ser Asp Gly Ser Phe Thr Leu Ser Leu His Glu Asp Glu Leu Phe 
    450                 455                 460                 


Thr Leu Thr Thr Leu Thr Thr Gly Arg Lys Gly Ser Tyr Pro Leu Pro 
465                 470                 475                 480 


Pro Lys Ser Gln Pro Phe Pro Ser Thr Tyr Lys Asp Asp Phe Asn Val 
                485                 490                 495     


Asp Tyr Pro Phe Phe Ser Glu Ala Pro Asn Phe Ala Asp Gln Thr Gly 
            500                 505                 510         


Val Phe Glu Tyr Phe Thr Asn Ile Glu Asp Pro Gly Glu His His Phe 
        515                 520                 525             


Thr Leu Arg Gln Val Leu Asn Gln Arg Pro Ile Thr Trp Ala Ala Asp 
    530                 535                 540                 


Ala Ser Asn Thr Ile Ser Ile Ile Gly Asp Tyr Asn Trp Thr Asn Leu 
545                 550                 555                 560 


Thr Ile Lys Cys Asp Val Tyr Ile Glu Thr Pro Asp Thr Gly Gly Val 
                565                 570                 575     


Phe Ile Ala Gly Arg Val Asn Lys Gly Gly Ile Leu Ile Arg Ser Ala 
            580                 585                 590         


Arg Gly Ile Phe Phe Trp Ile Phe Ala Asn Gly Ser Tyr Arg Val Thr 
        595                 600                 605             


Gly Asp Leu Ala Gly Trp Ile Ile Tyr Ala Leu Gly Arg Val Glu Val 
    610                 615                 620                 


Thr Ala Lys Lys Trp Tyr Thr Leu Thr Leu Thr Ile Lys Gly His Phe 
625                 630                 635                 640 


Thr Ser Gly Met Leu Asn Asp Lys Ser Leu Trp Thr Asp Ile Pro Val 
                645                 650                 655     


Asn Phe Pro Lys Asn Gly Trp Ala Ala Ile Gly Thr His Ser Phe Glu 
            660                 665                 670         


Phe Ala Gln Phe Asp Asn Phe Leu Val Glu Ala Thr Arg 
        675                 680                 685 


<210>  12
<211>  1011
<212>  PRT
<213>  Homo sapiens

<400>  12

Met Gly Ala Tyr Ala Arg Ala Ser Gly Val Cys Ala Arg Gly Cys Leu 
1               5                   10                  15      


Asp Ser Ala Gly Pro Trp Thr Met Ser Arg Ala Leu Arg Pro Pro Leu 
            20                  25                  30          


Pro Pro Leu Cys Phe Phe Leu Leu Leu Leu Ala Ala Ala Gly Ala Arg 
        35                  40                  45              


Ala Gly Gly Tyr Glu Thr Cys Pro Thr Val Gln Pro Asn Met Leu Asn 
    50                  55                  60                  


Val His Leu Leu Pro His Thr His Asp Asp Val Gly Trp Leu Lys Thr 
65                  70                  75                  80  


Val Asp Gln Tyr Phe Tyr Gly Ile Lys Asn Asp Ile Gln His Ala Gly 
                85                  90                  95      


Val Gln Tyr Ile Leu Asp Ser Val Ile Ser Ala Leu Leu Ala Asp Pro 
            100                 105                 110         


Thr Arg Arg Phe Ile Tyr Val Glu Ile Ala Phe Phe Ser Arg Trp Trp 
        115                 120                 125             


His Gln Gln Thr Asn Ala Thr Gln Glu Val Val Arg Asp Leu Val Arg 
    130                 135                 140                 


Gln Gly Arg Leu Glu Phe Ala Asn Gly Gly Trp Val Met Asn Asp Glu 
145                 150                 155                 160 


Ala Ala Thr His Tyr Gly Ala Ile Val Asp Gln Met Thr Leu Gly Leu 
                165                 170                 175     


Arg Phe Leu Glu Asp Thr Phe Gly Asn Asp Gly Arg Pro Arg Val Ala 
            180                 185                 190         


Trp His Ile Asp Pro Phe Gly His Ser Arg Glu Gln Ala Ser Leu Phe 
        195                 200                 205             


Ala Gln Met Gly Phe Asp Gly Phe Phe Phe Gly Arg Leu Asp Tyr Gln 
    210                 215                 220                 


Asp Lys Trp Val Arg Met Gln Lys Leu Glu Met Glu Gln Val Trp Arg 
225                 230                 235                 240 


Ala Ser Thr Ser Leu Lys Pro Pro Thr Ala Asp Leu Phe Thr Gly Val 
                245                 250                 255     


Leu Pro Asn Gly Tyr Asn Pro Pro Arg Asn Leu Cys Trp Asp Val Leu 
            260                 265                 270         


Cys Val Asp Gln Pro Leu Val Glu Asp Pro Arg Ser Pro Glu Tyr Asn 
        275                 280                 285             


Ala Lys Glu Leu Val Asp Tyr Phe Leu Asn Val Ala Thr Ala Gln Gly 
    290                 295                 300                 


Arg Tyr Tyr Arg Thr Asn His Thr Val Met Thr Met Gly Ser Asp Phe 
305                 310                 315                 320 


Gln Tyr Glu Asn Ala Asn Met Trp Phe Lys Asn Leu Asp Lys Leu Ile 
                325                 330                 335     


Arg Leu Val Asn Ala Gln Gln Ala Lys Gly Ser Ser Val His Val Leu 
            340                 345                 350         


Tyr Ser Thr Pro Ala Cys Tyr Leu Trp Glu Leu Asn Lys Ala Asn Leu 
        355                 360                 365             


Thr Trp Ser Val Lys His Asp Asp Phe Phe Pro Tyr Ala Asp Gly Pro 
    370                 375                 380                 


His Gln Phe Trp Thr Gly Tyr Phe Ser Ser Arg Pro Ala Leu Lys Arg 
385                 390                 395                 400 


Tyr Glu Arg Leu Ser Tyr Asn Phe Leu Gln Val Cys Asn Gln Leu Glu 
                405                 410                 415     


Ala Leu Val Gly Leu Ala Ala Asn Val Gly Pro Tyr Gly Ser Gly Asp 
            420                 425                 430         


Ser Ala Pro Leu Asn Glu Ala Met Ala Val Leu Gln His His Asp Ala 
        435                 440                 445             


Val Ser Gly Thr Ser Arg Gln His Val Ala Asn Asp Tyr Ala Arg Gln 
    450                 455                 460                 


Leu Ala Ala Gly Trp Gly Pro Cys Glu Val Leu Leu Ser Asn Ala Leu 
465                 470                 475                 480 


Ala Arg Leu Arg Gly Phe Lys Asp His Phe Thr Phe Cys Gln Gln Leu 
                485                 490                 495     


Asn Ile Ser Ile Cys Pro Leu Ser Gln Thr Ala Ala Arg Phe Gln Val 
            500                 505                 510         


Ile Val Tyr Asn Pro Leu Gly Arg Lys Val Asn Trp Met Val Arg Leu 
        515                 520                 525             


Pro Val Ser Glu Gly Val Phe Val Val Lys Asp Pro Asn Gly Arg Thr 
    530                 535                 540                 


Val Pro Ser Asp Val Val Ile Phe Pro Ser Ser Asp Ser Gln Ala His 
545                 550                 555                 560 


Pro Pro Glu Leu Leu Phe Ser Ala Ser Leu Pro Ala Leu Gly Phe Ser 
                565                 570                 575     


Thr Tyr Ser Val Ala Gln Val Pro Arg Trp Lys Pro Gln Ala Arg Ala 
            580                 585                 590         


Pro Gln Pro Ile Pro Arg Arg Ser Trp Ser Pro Ala Leu Thr Ile Glu 
        595                 600                 605             


Asn Glu His Ile Arg Ala Thr Phe Asp Pro Asp Thr Gly Leu Leu Met 
    610                 615                 620                 


Glu Ile Met Asn Met Asn Gln Gln Leu Leu Leu Pro Val Arg Gln Thr 
625                 630                 635                 640 


Phe Phe Trp Tyr Asn Ala Ser Ile Gly Asp Asn Glu Ser Asp Gln Ala 
                645                 650                 655     


Ser Gly Ala Tyr Ile Phe Arg Pro Asn Gln Gln Lys Pro Leu Pro Val 
            660                 665                 670         


Ser Arg Trp Ala Gln Ile His Leu Val Lys Thr Pro Leu Val Gln Glu 
        675                 680                 685             


Val His Gln Asn Phe Ser Ala Trp Cys Ser Gln Val Val Arg Leu Tyr 
    690                 695                 700                 


Pro Gly Gln Arg His Leu Glu Leu Glu Trp Ser Val Gly Pro Ile Pro 
705                 710                 715                 720 


Val Gly Asp Thr Trp Gly Lys Glu Val Ile Ser Arg Phe Asp Thr Pro 
                725                 730                 735     


Leu Glu Thr Lys Gly Arg Phe Tyr Thr Asp Ser Asn Gly Arg Glu Ile 
            740                 745                 750         


Leu Glu Arg Arg Arg Asp Tyr Arg Pro Thr Trp Lys Leu Asn Gln Thr 
        755                 760                 765             


Glu Pro Val Ala Gly Asn Tyr Tyr Pro Val Asn Thr Arg Ile Tyr Ile 
    770                 775                 780                 


Thr Asp Gly Asn Met Gln Leu Thr Val Leu Thr Asp Arg Ser Gln Gly 
785                 790                 795                 800 


Gly Ser Ser Leu Arg Asp Gly Ser Leu Glu Leu Met Val His Arg Arg 
                805                 810                 815     


Leu Leu Lys Asp Asp Gly Arg Gly Val Ser Glu Pro Leu Met Glu Asn 
            820                 825                 830         


Gly Ser Gly Ala Trp Val Arg Gly Arg His Leu Val Leu Leu Asp Thr 
        835                 840                 845             


Ala Gln Ala Ala Ala Ala Gly His Arg Leu Leu Ala Glu Gln Glu Val 
    850                 855                 860                 


Leu Ala Pro Gln Val Val Leu Ala Pro Gly Gly Gly Ala Ala Tyr Asn 
865                 870                 875                 880 


Leu Gly Ala Pro Pro Arg Thr Gln Phe Ser Gly Leu Arg Arg Asp Leu 
                885                 890                 895     


Pro Pro Ser Val His Leu Leu Thr Leu Ala Ser Trp Gly Pro Glu Met 
            900                 905                 910         


Val Leu Leu Arg Leu Glu His Gln Phe Ala Val Gly Glu Asp Ser Gly 
        915                 920                 925             


Arg Asn Leu Ser Ala Pro Val Thr Leu Asn Leu Arg Asp Leu Phe Ser 
    930                 935                 940                 


Thr Phe Thr Ile Thr Arg Leu Gln Glu Thr Thr Leu Val Ala Asn Gln 
945                 950                 955                 960 


Leu Arg Glu Ala Ala Ser Arg Leu Lys Trp Thr Thr Asn Thr Gly Pro 
                965                 970                 975     


Thr Pro His Gln Thr Pro Tyr Gln Leu Asp Pro Ala Asn Ile Thr Leu 
            980                 985                 990         


Glu Pro Met Glu Ile Arg Thr Phe  Leu Ala Ser Val Gln  Trp Lys Glu 
        995                 1000                 1005             


Val Asp  Gly 
    1010     


<210>  13
<211>  879
<212>  PRT
<213>  Homo sapiens

<400>  13

Met Arg Leu His Leu Leu Leu Leu Leu Ala Leu Cys Gly Ala Gly Thr 
1               5                   10                  15      


Thr Ala Ala Glu Leu Ser Tyr Ser Leu Arg Gly Asn Trp Ser Ile Cys 
            20                  25                  30          


Asn Gly Asn Gly Ser Leu Glu Leu Pro Gly Ala Val Pro Gly Cys Val 
        35                  40                  45              


His Ser Ala Leu Phe Gln Gln Gly Leu Ile Gln Asp Ser Tyr Tyr Arg 
    50                  55                  60                  


Phe Asn Asp Leu Asn Tyr Arg Trp Val Ser Leu Asp Asn Trp Thr Tyr 
65                  70                  75                  80  


Ser Lys Glu Phe Lys Ile Pro Phe Glu Ile Ser Lys Trp Gln Lys Val 
                85                  90                  95      


Asn Leu Ile Leu Glu Gly Val Asp Thr Val Ser Lys Ile Leu Phe Asn 
            100                 105                 110         


Glu Val Thr Ile Gly Glu Thr Asp Asn Met Phe Asn Arg Tyr Ser Phe 
        115                 120                 125             


Asp Ile Thr Asn Val Val Arg Asp Val Asn Ser Ile Glu Leu Arg Phe 
    130                 135                 140                 


Gln Ser Ala Val Leu Tyr Ala Ala Gln Gln Ser Lys Ala His Thr Arg 
145                 150                 155                 160 


Tyr Gln Val Pro Pro Asp Cys Pro Pro Leu Val Gln Lys Gly Glu Cys 
                165                 170                 175     


His Val Asn Phe Val Arg Lys Glu Gln Cys Ser Phe Ser Trp Asp Trp 
            180                 185                 190         


Gly Pro Ser Phe Pro Thr Gln Gly Ile Trp Lys Asp Val Arg Ile Glu 
        195                 200                 205             


Ala Tyr Asn Ile Cys His Leu Asn Tyr Phe Thr Phe Ser Pro Ile Tyr 
    210                 215                 220                 


Asp Lys Ser Ala Gln Glu Trp Asn Leu Glu Ile Glu Ser Thr Phe Asp 
225                 230                 235                 240 


Val Val Ser Ser Lys Pro Val Gly Gly Gln Val Ile Val Ala Ile Pro 
                245                 250                 255     


Lys Leu Gln Thr Gln Gln Thr Tyr Ser Ile Glu Leu Gln Pro Gly Lys 
            260                 265                 270         


Arg Ile Val Glu Leu Phe Val Asn Ile Ser Lys Asn Ile Thr Val Glu 
        275                 280                 285             


Thr Trp Trp Pro His Gly His Gly Asn Gln Thr Gly Tyr Asn Met Thr 
    290                 295                 300                 


Val Leu Phe Glu Leu Asp Gly Gly Leu Asn Ile Glu Lys Ser Ala Lys 
305                 310                 315                 320 


Val Tyr Phe Arg Thr Val Glu Leu Ile Glu Glu Pro Ile Lys Gly Ser 
                325                 330                 335     


Pro Gly Leu Ser Phe Tyr Phe Lys Ile Asn Gly Phe Pro Ile Phe Leu 
            340                 345                 350         


Lys Gly Ser Asn Trp Ile Pro Ala Asp Ser Phe Gln Asp Arg Val Thr 
        355                 360                 365             


Ser Glu Leu Leu Arg Leu Leu Leu Gln Ser Val Val Asp Ala Asn Met 
    370                 375                 380                 


Asn Thr Leu Arg Val Trp Gly Gly Gly Ile Tyr Glu Gln Asp Glu Phe 
385                 390                 395                 400 


Tyr Glu Leu Cys Asp Glu Leu Gly Ile Met Val Trp Gln Asp Phe Met 
                405                 410                 415     


Phe Ala Cys Ala Leu Tyr Pro Thr Asp Gln Gly Phe Leu Asp Ser Val 
            420                 425                 430         


Thr Ala Glu Val Ala Tyr Gln Ile Lys Arg Leu Lys Ser His Pro Ser 
        435                 440                 445             


Ile Ile Ile Trp Ser Gly Asn Asn Glu Asn Glu Glu Ala Leu Met Met 
    450                 455                 460                 


Asn Trp Tyr His Ile Ser Phe Thr Asp Arg Pro Ile Tyr Ile Lys Asp 
465                 470                 475                 480 


Tyr Val Thr Leu Tyr Val Lys Asn Ile Arg Glu Leu Val Leu Ala Gly 
                485                 490                 495     


Asp Lys Ser Arg Pro Phe Ile Thr Ser Ser Pro Thr Asn Gly Ala Glu 
            500                 505                 510         


Thr Val Ala Glu Ala Trp Val Ser Gln Asn Pro Asn Ser Asn Tyr Phe 
        515                 520                 525             


Gly Asp Val His Phe Tyr Asp Tyr Ile Ser Asp Cys Trp Asn Trp Lys 
    530                 535                 540                 


Val Phe Pro Lys Ala Arg Phe Ala Ser Glu Tyr Gly Tyr Gln Ser Trp 
545                 550                 555                 560 


Pro Ser Phe Ser Thr Leu Glu Lys Val Ser Ser Thr Glu Asp Trp Ser 
                565                 570                 575     


Phe Asn Ser Lys Phe Ser Leu His Arg Gln His His Glu Gly Gly Asn 
            580                 585                 590         


Lys Gln Met Leu Tyr Gln Ala Gly Leu His Phe Lys Leu Pro Gln Ser 
        595                 600                 605             


Thr Asp Pro Leu Arg Thr Phe Lys Asp Thr Ile Tyr Leu Thr Gln Val 
    610                 615                 620                 


Met Gln Ala Gln Cys Val Lys Thr Glu Thr Glu Phe Tyr Arg Arg Ser 
625                 630                 635                 640 


Arg Ser Glu Ile Val Asp Gln Gln Gly His Thr Met Gly Ala Leu Tyr 
                645                 650                 655     


Trp Gln Leu Asn Asp Ile Trp Gln Ala Pro Ser Trp Ala Ser Leu Glu 
            660                 665                 670         


Tyr Gly Gly Lys Trp Lys Met Leu His Tyr Phe Ala Gln Asn Phe Phe 
        675                 680                 685             


Ala Pro Leu Leu Pro Val Gly Phe Glu Asn Glu Asn Thr Phe Tyr Ile 
    690                 695                 700                 


Tyr Gly Val Ser Asp Leu His Ser Asp Tyr Ser Met Thr Leu Ser Val 
705                 710                 715                 720 


Arg Val His Thr Trp Ser Ser Leu Glu Pro Val Cys Ser Arg Val Thr 
                725                 730                 735     


Glu Arg Phe Val Met Lys Gly Gly Glu Ala Val Cys Leu Tyr Glu Glu 
            740                 745                 750         


Pro Val Ser Glu Leu Leu Arg Arg Cys Gly Asn Cys Thr Arg Glu Ser 
        755                 760                 765             


Cys Val Val Ser Phe Tyr Leu Ser Ala Asp His Glu Leu Leu Ser Pro 
    770                 775                 780                 


Thr Asn Tyr His Phe Leu Ser Ser Pro Lys Glu Ala Val Gly Leu Cys 
785                 790                 795                 800 


Lys Ala Gln Ile Thr Ala Ile Ile Ser Gln Gln Gly Asp Ile Phe Val 
                805                 810                 815     


Phe Asp Leu Glu Thr Ser Ala Val Ala Pro Phe Val Trp Leu Asp Val 
            820                 825                 830         


Gly Ser Ile Pro Gly Arg Phe Ser Asp Asn Gly Phe Leu Met Thr Glu 
        835                 840                 845             


Lys Thr Arg Thr Ile Leu Phe Tyr Pro Trp Glu Pro Thr Ser Lys Asn 
    850                 855                 860                 


Glu Leu Glu Gln Ser Phe His Val Thr Ser Leu Thr Asp Ile Tyr 
865                 870                 875                 


<210>  14
<211>  507
<212>  PRT
<213>  Homo sapiens

<400>  14

Met Gly Ala Pro Arg Ser Leu Leu Leu Ala Leu Ala Ala Gly Leu Ala 
1               5                   10                  15      


Val Ala Arg Pro Pro Asn Ile Val Leu Ile Phe Ala Asp Asp Leu Gly 
            20                  25                  30          


Tyr Gly Asp Leu Gly Cys Tyr Gly His Pro Ser Ser Thr Thr Pro Asn 
        35                  40                  45              


Leu Asp Gln Leu Ala Ala Gly Gly Leu Arg Phe Thr Asp Phe Tyr Val 
    50                  55                  60                  


Pro Val Ser Leu Cys Thr Pro Ser Arg Ala Ala Leu Leu Thr Gly Arg 
65                  70                  75                  80  


Leu Pro Val Arg Met Gly Met Tyr Pro Gly Val Leu Val Pro Ser Ser 
                85                  90                  95      


Arg Gly Gly Leu Pro Leu Glu Glu Val Thr Val Ala Glu Val Leu Ala 
            100                 105                 110         


Ala Arg Gly Tyr Leu Thr Gly Met Ala Gly Lys Trp His Leu Gly Val 
        115                 120                 125             


Gly Pro Glu Gly Ala Phe Leu Pro Pro His Gln Gly Phe His Arg Phe 
    130                 135                 140                 


Leu Gly Ile Pro Tyr Ser His Asp Gln Gly Pro Cys Gln Asn Leu Thr 
145                 150                 155                 160 


Cys Phe Pro Pro Ala Thr Pro Cys Asp Gly Gly Cys Asp Gln Gly Leu 
                165                 170                 175     


Val Pro Ile Pro Leu Leu Ala Asn Leu Ser Val Glu Ala Gln Pro Pro 
            180                 185                 190         


Trp Leu Pro Gly Leu Glu Ala Arg Tyr Met Ala Phe Ala His Asp Leu 
        195                 200                 205             


Met Ala Asp Ala Gln Arg Gln Asp Arg Pro Phe Phe Leu Tyr Tyr Ala 
    210                 215                 220                 


Ser His His Thr His Tyr Pro Gln Phe Ser Gly Gln Ser Phe Ala Glu 
225                 230                 235                 240 


Arg Ser Gly Arg Gly Pro Phe Gly Asp Ser Leu Met Glu Leu Asp Ala 
                245                 250                 255     


Ala Val Gly Thr Leu Met Thr Ala Ile Gly Asp Leu Gly Leu Leu Glu 
            260                 265                 270         


Glu Thr Leu Val Ile Phe Thr Ala Asp Asn Gly Pro Glu Thr Met Arg 
        275                 280                 285             


Met Ser Arg Gly Gly Cys Ser Gly Leu Leu Arg Cys Gly Lys Gly Thr 
    290                 295                 300                 


Thr Tyr Glu Gly Gly Val Arg Glu Pro Ala Leu Ala Phe Trp Pro Gly 
305                 310                 315                 320 


His Ile Ala Pro Gly Val Thr His Glu Leu Ala Ser Ser Leu Asp Leu 
                325                 330                 335     


Leu Pro Thr Leu Ala Ala Leu Ala Gly Ala Pro Leu Pro Asn Val Thr 
            340                 345                 350         


Leu Asp Gly Phe Asp Leu Ser Pro Leu Leu Leu Gly Thr Gly Lys Ser 
        355                 360                 365             


Pro Arg Gln Ser Leu Phe Phe Tyr Pro Ser Tyr Pro Asp Glu Val Arg 
    370                 375                 380                 


Gly Val Phe Ala Val Arg Thr Gly Lys Tyr Lys Ala His Phe Phe Thr 
385                 390                 395                 400 


Gln Gly Ser Ala His Ser Asp Thr Thr Ala Asp Pro Ala Cys His Ala 
                405                 410                 415     


Ser Ser Ser Leu Thr Ala His Glu Pro Pro Leu Leu Tyr Asp Leu Ser 
            420                 425                 430         


Lys Asp Pro Gly Glu Asn Tyr Asn Leu Leu Gly Gly Val Ala Gly Ala 
        435                 440                 445             


Thr Pro Glu Val Leu Gln Ala Leu Lys Gln Leu Gln Leu Leu Lys Ala 
    450                 455                 460                 


Gln Leu Asp Ala Ala Val Thr Phe Gly Pro Ser Gln Val Ala Arg Gly 
465                 470                 475                 480 


Glu Asp Pro Ala Leu Gln Ile Cys Cys His Pro Gly Cys Thr Pro Arg 
                485                 490                 495     


Pro Ala Cys Cys His Cys Pro Asp Pro His Ala 
            500                 505         


<210>  15
<211>  507
<212>  PRT
<213>  Homo sapiens

<400>  15

Met Gly Ala Pro Arg Ser Leu Leu Leu Ala Leu Ala Ala Gly Leu Ala 
1               5                   10                  15      


Val Ala Arg Pro Pro Asn Ile Val Leu Ile Phe Ala Asp Asp Leu Gly 
            20                  25                  30          


Tyr Gly Asp Leu Gly Cys Tyr Gly His Pro Ser Ser Thr Thr Pro Asn 
        35                  40                  45              


Leu Asp Gln Leu Ala Ala Gly Gly Leu Arg Phe Thr Asp Phe Tyr Val 
    50                  55                  60                  


Pro Val Ser Leu Cys Thr Pro Ser Arg Ala Ala Leu Leu Thr Gly Arg 
65                  70                  75                  80  


Leu Pro Val Arg Met Gly Met Tyr Pro Gly Val Leu Val Pro Ser Ser 
                85                  90                  95      


Arg Gly Gly Leu Pro Leu Glu Glu Val Thr Val Ala Glu Val Leu Ala 
            100                 105                 110         


Ala Arg Gly Tyr Leu Thr Gly Met Ala Gly Lys Trp His Leu Gly Val 
        115                 120                 125             


Gly Pro Glu Gly Ala Phe Leu Pro Pro His Gln Gly Phe His Arg Phe 
    130                 135                 140                 


Leu Gly Ile Pro Tyr Ser His Asp Gln Gly Pro Cys Gln Asn Leu Thr 
145                 150                 155                 160 


Cys Phe Pro Pro Ala Thr Pro Cys Asp Gly Gly Cys Asp Gln Gly Leu 
                165                 170                 175     


Val Pro Ile Pro Leu Leu Ala Asn Leu Ser Val Glu Ala Gln Pro Pro 
            180                 185                 190         


Trp Leu Pro Gly Leu Glu Ala Arg Tyr Met Ala Phe Ala His Asp Leu 
        195                 200                 205             


Met Ala Asp Ala Gln Arg Gln Asp Arg Pro Phe Phe Leu Tyr Tyr Ala 
    210                 215                 220                 


Ser His His Thr His Tyr Pro Gln Phe Ser Gly Gln Ser Phe Ala Glu 
225                 230                 235                 240 


Arg Ser Gly Arg Gly Pro Phe Gly Asp Ser Leu Met Glu Leu Asp Ala 
                245                 250                 255     


Ala Val Gly Thr Leu Met Thr Ala Ile Gly Asp Leu Gly Leu Leu Glu 
            260                 265                 270         


Glu Thr Leu Val Ile Phe Thr Ala Asp Asn Gly Pro Glu Thr Met Arg 
        275                 280                 285             


Met Ser Arg Gly Gly Cys Ser Gly Leu Leu Arg Cys Gly Lys Gly Thr 
    290                 295                 300                 


Thr Tyr Glu Gly Gly Val Arg Glu Pro Ala Leu Ala Phe Trp Pro Gly 
305                 310                 315                 320 


His Ile Ala Pro Gly Val Thr His Glu Leu Ala Ser Ser Leu Asp Leu 
                325                 330                 335     


Leu Pro Thr Leu Ala Ala Leu Ala Gly Ala Pro Leu Pro Asn Val Thr 
            340                 345                 350         


Leu Asp Gly Phe Asp Leu Ser Pro Leu Leu Leu Gly Thr Gly Lys Ser 
        355                 360                 365             


Pro Arg Gln Ser Leu Phe Phe Tyr Pro Ser Tyr Pro Asp Glu Val Arg 
    370                 375                 380                 


Gly Val Phe Ala Val Arg Thr Gly Lys Tyr Lys Ala His Phe Phe Thr 
385                 390                 395                 400 


Gln Gly Ser Ala His Ser Asp Thr Thr Ala Asp Pro Ala Cys His Ala 
                405                 410                 415     


Ser Ser Ser Leu Thr Ala His Glu Pro Pro Leu Leu Tyr Asp Leu Ser 
            420                 425                 430         


Lys Asp Pro Gly Glu Asn Tyr Asn Leu Leu Gly Gly Val Ala Gly Ala 
        435                 440                 445             


Thr Pro Glu Val Leu Gln Ala Leu Lys Gln Leu Gln Leu Leu Lys Ala 
    450                 455                 460                 


Gln Leu Asp Ala Ala Val Thr Phe Gly Pro Ser Gln Val Ala Arg Gly 
465                 470                 475                 480 


Glu Asp Pro Ala Leu Gln Ile Cys Cys His Pro Gly Cys Thr Pro Arg 
                485                 490                 495     


Pro Ala Cys Cys His Cys Pro Asp Pro His Ala 
            500                 505         


<210>  16
<211>  522
<212>  PRT
<213>  Homo sapiens

<400>  16

Met Ala Ala Val Val Ala Ala Thr Arg Trp Trp Gln Leu Leu Leu Val 
1               5                   10                  15      


Leu Ser Ala Ala Gly Met Gly Ala Ser Gly Ala Pro Gln Pro Pro Asn 
            20                  25                  30          


Ile Leu Leu Leu Leu Met Asp Asp Met Gly Trp Gly Asp Leu Gly Val 
        35                  40                  45              


Tyr Gly Glu Pro Ser Arg Glu Thr Pro Asn Leu Asp Arg Met Ala Ala 
    50                  55                  60                  


Glu Gly Leu Leu Phe Pro Asn Phe Tyr Ser Ala Asn Pro Leu Cys Ser 
65                  70                  75                  80  


Pro Ser Arg Ala Ala Leu Leu Thr Gly Arg Leu Pro Ile Arg Asn Gly 
                85                  90                  95      


Phe Tyr Thr Thr Asn Ala His Ala Arg Asn Ala Tyr Thr Pro Gln Glu 
            100                 105                 110         


Ile Val Gly Gly Ile Pro Asp Ser Glu Gln Leu Leu Pro Glu Leu Leu 
        115                 120                 125             


Lys Lys Ala Gly Tyr Val Ser Lys Ile Val Gly Lys Trp His Leu Gly 
    130                 135                 140                 


His Arg Pro Gln Phe His Pro Leu Lys His Gly Phe Asp Glu Trp Phe 
145                 150                 155                 160 


Gly Ser Pro Asn Cys His Phe Gly Pro Tyr Asp Asn Lys Ala Arg Pro 
                165                 170                 175     


Asn Ile Pro Val Tyr Arg Asp Trp Glu Met Val Gly Arg Tyr Tyr Glu 
            180                 185                 190         


Glu Phe Pro Ile Asn Leu Lys Thr Gly Glu Ala Asn Leu Thr Gln Ile 
        195                 200                 205             


Tyr Leu Gln Glu Ala Leu Asp Phe Ile Lys Arg Gln Ala Arg His His 
    210                 215                 220                 


Pro Phe Phe Leu Tyr Trp Ala Val Asp Ala Thr His Ala Pro Val Tyr 
225                 230                 235                 240 


Ala Ser Lys Pro Phe Leu Gly Thr Ser Gln Arg Gly Arg Tyr Gly Asp 
                245                 250                 255     


Ala Val Arg Glu Ile Asp Asp Ser Ile Gly Lys Ile Leu Glu Leu Leu 
            260                 265                 270         


Gln Asp Leu His Val Ala Asp Asn Thr Phe Val Phe Phe Thr Ser Asp 
        275                 280                 285             


Asn Gly Ala Ala Leu Ile Ser Ala Pro Glu Gln Gly Gly Ser Asn Gly 
    290                 295                 300                 


Pro Phe Leu Cys Gly Lys Gln Thr Thr Phe Glu Gly Gly Met Arg Glu 
305                 310                 315                 320 


Pro Ala Leu Ala Trp Trp Pro Gly His Val Thr Ala Gly Gln Val Ser 
                325                 330                 335     


His Gln Leu Gly Ser Ile Met Asp Leu Phe Thr Thr Ser Leu Ala Leu 
            340                 345                 350         


Ala Gly Leu Thr Pro Pro Ser Asp Arg Ala Ile Asp Gly Leu Asn Leu 
        355                 360                 365             


Leu Pro Thr Leu Leu Gln Gly Arg Leu Met Asp Arg Pro Ile Phe Tyr 
    370                 375                 380                 


Tyr Arg Gly Asp Thr Leu Met Ala Ala Thr Leu Gly Gln His Lys Ala 
385                 390                 395                 400 


His Phe Trp Thr Trp Thr Asn Ser Trp Glu Asn Phe Arg Gln Gly Ile 
                405                 410                 415     


Asp Phe Cys Pro Gly Gln Asn Val Ser Gly Val Thr Thr His Asn Leu 
            420                 425                 430         


Glu Asp His Thr Lys Leu Pro Leu Ile Phe His Leu Gly Arg Asp Pro 
        435                 440                 445             


Gly Glu Arg Phe Pro Leu Ser Phe Ala Ser Ala Glu Tyr Gln Glu Ala 
    450                 455                 460                 


Leu Ser Arg Ile Thr Ser Val Val Gln Gln His Gln Glu Ala Leu Val 
465                 470                 475                 480 


Pro Ala Gln Pro Gln Leu Asn Val Cys Asn Trp Ala Val Met Asn Trp 
                485                 490                 495     


Ala Pro Pro Gly Cys Glu Lys Leu Gly Lys Cys Leu Thr Pro Pro Glu 
            500                 505                 510         


Ser Ile Pro Lys Lys Cys Leu Trp Ser His 
        515                 520         


<210>  17
<211>  631
<212>  PRT
<213>  Homo sapiens

<400>  17

Met Pro Arg Tyr Gly Ala Ser Leu Arg Gln Ser Cys Pro Arg Ser Gly 
1               5                   10                  15      


Arg Glu Gln Gly Gln Asp Gly Thr Ala Gly Ala Pro Gly Leu Leu Trp 
            20                  25                  30          


Met Gly Leu Val Leu Ala Leu Ala Leu Ala Leu Ala Leu Ala Leu Ala 
        35                  40                  45              


Leu Ser Asp Ser Arg Val Leu Trp Ala Pro Ala Glu Ala His Pro Leu 
    50                  55                  60                  


Ser Pro Gln Gly His Pro Ala Arg Leu His Arg Ile Val Pro Arg Leu 
65                  70                  75                  80  


Arg Asp Val Phe Gly Trp Gly Asn Leu Thr Cys Pro Ile Cys Lys Gly 
                85                  90                  95      


Leu Phe Thr Ala Ile Asn Leu Gly Leu Lys Lys Glu Pro Asn Val Ala 
            100                 105                 110         


Arg Val Gly Ser Val Ala Ile Lys Leu Cys Asn Leu Leu Lys Ile Ala 
        115                 120                 125             


Pro Pro Ala Val Cys Gln Ser Ile Val His Leu Phe Glu Asp Asp Met 
    130                 135                 140                 


Val Glu Val Trp Arg Arg Ser Val Leu Ser Pro Ser Glu Ala Cys Gly 
145                 150                 155                 160 


Leu Leu Leu Gly Ser Thr Cys Gly His Trp Asp Ile Phe Ser Ser Trp 
                165                 170                 175     


Asn Ile Ser Leu Pro Thr Val Pro Lys Pro Pro Pro Lys Pro Pro Ser 
            180                 185                 190         


Pro Pro Ala Pro Gly Ala Pro Val Ser Arg Ile Leu Phe Leu Thr Asp 
        195                 200                 205             


Leu His Trp Asp His Asp Tyr Leu Glu Gly Thr Asp Pro Asp Cys Ala 
    210                 215                 220                 


Asp Pro Leu Cys Cys Arg Arg Gly Ser Gly Leu Pro Pro Ala Ser Arg 
225                 230                 235                 240 


Pro Gly Ala Gly Tyr Trp Gly Glu Tyr Ser Lys Cys Asp Leu Pro Leu 
                245                 250                 255     


Arg Thr Leu Glu Ser Leu Leu Ser Gly Leu Gly Pro Ala Gly Pro Phe 
            260                 265                 270         


Asp Met Val Tyr Trp Thr Gly Asp Ile Pro Ala His Asp Val Trp His 
        275                 280                 285             


Gln Thr Arg Gln Asp Gln Leu Arg Ala Leu Thr Thr Val Thr Ala Leu 
    290                 295                 300                 


Val Arg Lys Phe Leu Gly Pro Val Pro Val Tyr Pro Ala Val Gly Asn 
305                 310                 315                 320 


His Glu Ser Thr Pro Val Asn Ser Phe Pro Pro Pro Phe Ile Glu Gly 
                325                 330                 335     


Asn His Ser Ser Arg Trp Leu Tyr Glu Ala Met Ala Lys Ala Trp Glu 
            340                 345                 350         


Pro Trp Leu Pro Ala Glu Ala Leu Arg Thr Leu Arg Ile Gly Gly Phe 
        355                 360                 365             


Tyr Ala Leu Ser Pro Tyr Pro Gly Leu Arg Leu Ile Ser Leu Asn Met 
    370                 375                 380                 


Asn Phe Cys Ser Arg Glu Asn Phe Trp Leu Leu Ile Asn Ser Thr Asp 
385                 390                 395                 400 


Pro Ala Gly Gln Leu Gln Trp Leu Val Gly Glu Leu Gln Ala Ala Glu 
                405                 410                 415     


Asp Arg Gly Asp Lys Val His Ile Ile Gly His Ile Pro Pro Gly His 
            420                 425                 430         


Cys Leu Lys Ser Trp Ser Trp Asn Tyr Tyr Arg Ile Val Ala Arg Tyr 
        435                 440                 445             


Glu Asn Thr Leu Ala Ala Gln Phe Phe Gly His Thr His Val Asp Glu 
    450                 455                 460                 


Phe Glu Val Phe Tyr Asp Glu Glu Thr Leu Ser Arg Pro Leu Ala Val 
465                 470                 475                 480 


Ala Phe Leu Ala Pro Ser Ala Thr Thr Tyr Ile Gly Leu Asn Pro Gly 
                485                 490                 495     


Tyr Arg Val Tyr Gln Ile Asp Gly Asn Tyr Ser Gly Ser Ser His Val 
            500                 505                 510         


Val Leu Asp His Glu Thr Tyr Ile Leu Asn Leu Thr Gln Ala Asn Ile 
        515                 520                 525             


Pro Gly Ala Ile Pro His Trp Gln Leu Leu Tyr Arg Ala Arg Glu Thr 
    530                 535                 540                 


Tyr Gly Leu Pro Asn Thr Leu Pro Thr Ala Trp His Asn Leu Val Tyr 
545                 550                 555                 560 


Arg Met Arg Gly Asp Met Gln Leu Phe Gln Thr Phe Trp Phe Leu Tyr 
                565                 570                 575     


His Lys Gly His Pro Pro Ser Glu Pro Cys Gly Thr Pro Cys Arg Leu 
            580                 585                 590         


Ala Thr Leu Cys Ala Gln Leu Ser Ala Arg Ala Asp Ser Pro Ala Leu 
        595                 600                 605             


Cys Arg His Leu Met Pro Asp Gly Ser Leu Pro Glu Ala Gln Ser Leu 
    610                 615                 620                 


Trp Pro Arg Pro Leu Phe Cys 
625                 630     


<210>  18
<211>  952
<212>  PRT
<213>  Homo sapiens

<400>  18

Met Gly Val Arg His Pro Pro Cys Ser His Arg Leu Leu Ala Val Cys 
1               5                   10                  15      


Ala Leu Val Ser Leu Ala Thr Ala Ala Leu Leu Gly His Ile Leu Leu 
            20                  25                  30          


His Asp Phe Leu Leu Val Pro Arg Glu Leu Ser Gly Ser Ser Pro Val 
        35                  40                  45              


Leu Glu Glu Thr His Pro Ala His Gln Gln Gly Ala Ser Arg Pro Gly 
    50                  55                  60                  


Pro Arg Asp Ala Gln Ala His Pro Gly Arg Pro Arg Ala Val Pro Thr 
65                  70                  75                  80  


Gln Cys Asp Val Pro Pro Asn Ser Arg Phe Asp Cys Ala Pro Asp Lys 
                85                  90                  95      


Ala Ile Thr Gln Glu Gln Cys Glu Ala Arg Gly Cys Cys Tyr Ile Pro 
            100                 105                 110         


Ala Lys Gln Gly Leu Gln Gly Ala Gln Met Gly Gln Pro Trp Cys Phe 
        115                 120                 125             


Phe Pro Pro Ser Tyr Pro Ser Tyr Lys Leu Glu Asn Leu Ser Ser Ser 
    130                 135                 140                 


Glu Met Gly Tyr Thr Ala Thr Leu Thr Arg Thr Thr Pro Thr Phe Phe 
145                 150                 155                 160 


Pro Lys Asp Ile Leu Thr Leu Arg Leu Asp Val Met Met Glu Thr Glu 
                165                 170                 175     


Asn Arg Leu His Phe Thr Ile Lys Asp Pro Ala Asn Arg Arg Tyr Glu 
            180                 185                 190         


Val Pro Leu Glu Thr Pro His Val His Ser Arg Ala Pro Ser Pro Leu 
        195                 200                 205             


Tyr Ser Val Glu Phe Ser Glu Glu Pro Phe Gly Val Ile Val Arg Arg 
    210                 215                 220                 


Gln Leu Asp Gly Arg Val Leu Leu Asn Thr Thr Val Ala Pro Leu Phe 
225                 230                 235                 240 


Phe Ala Asp Gln Phe Leu Gln Leu Ser Thr Ser Leu Pro Ser Gln Tyr 
                245                 250                 255     


Ile Thr Gly Leu Ala Glu His Leu Ser Pro Leu Met Leu Ser Thr Ser 
            260                 265                 270         


Trp Thr Arg Ile Thr Leu Trp Asn Arg Asp Leu Ala Pro Thr Pro Gly 
        275                 280                 285             


Ala Asn Leu Tyr Gly Ser His Pro Phe Tyr Leu Ala Leu Glu Asp Gly 
    290                 295                 300                 


Gly Ser Ala His Gly Val Phe Leu Leu Asn Ser Asn Ala Met Asp Val 
305                 310                 315                 320 


Val Leu Gln Pro Ser Pro Ala Leu Ser Trp Arg Ser Thr Gly Gly Ile 
                325                 330                 335     


Leu Asp Val Tyr Ile Phe Leu Gly Pro Glu Pro Lys Ser Val Val Gln 
            340                 345                 350         


Gln Tyr Leu Asp Val Val Gly Tyr Pro Phe Met Pro Pro Tyr Trp Gly 
        355                 360                 365             


Leu Gly Phe His Leu Cys Arg Trp Gly Tyr Ser Ser Thr Ala Ile Thr 
    370                 375                 380                 


Arg Gln Val Val Glu Asn Met Thr Arg Ala His Phe Pro Leu Asp Val 
385                 390                 395                 400 


Gln Trp Asn Asp Leu Asp Tyr Met Asp Ser Arg Arg Asp Phe Thr Phe 
                405                 410                 415     


Asn Lys Asp Gly Phe Arg Asp Phe Pro Ala Met Val Gln Glu Leu His 
            420                 425                 430         


Gln Gly Gly Arg Arg Tyr Met Met Ile Val Asp Pro Ala Ile Ser Ser 
        435                 440                 445             


Ser Gly Pro Ala Gly Ser Tyr Arg Pro Tyr Asp Glu Gly Leu Arg Arg 
    450                 455                 460                 


Gly Val Phe Ile Thr Asn Glu Thr Gly Gln Pro Leu Ile Gly Lys Val 
465                 470                 475                 480 


Trp Pro Gly Ser Thr Ala Phe Pro Asp Phe Thr Asn Pro Thr Ala Leu 
                485                 490                 495     


Ala Trp Trp Glu Asp Met Val Ala Glu Phe His Asp Gln Val Pro Phe 
            500                 505                 510         


Asp Gly Met Trp Ile Asp Met Asn Glu Pro Ser Asn Phe Ile Arg Gly 
        515                 520                 525             


Ser Glu Asp Gly Cys Pro Asn Asn Glu Leu Glu Asn Pro Pro Tyr Val 
    530                 535                 540                 


Pro Gly Val Val Gly Gly Thr Leu Gln Ala Ala Thr Ile Cys Ala Ser 
545                 550                 555                 560 


Ser His Gln Phe Leu Ser Thr His Tyr Asn Leu His Asn Leu Tyr Gly 
                565                 570                 575     


Leu Thr Glu Ala Ile Ala Ser His Arg Ala Leu Val Lys Ala Arg Gly 
            580                 585                 590         


Thr Arg Pro Phe Val Ile Ser Arg Ser Thr Phe Ala Gly His Gly Arg 
        595                 600                 605             


Tyr Ala Gly His Trp Thr Gly Asp Val Trp Ser Ser Trp Glu Gln Leu 
    610                 615                 620                 


Ala Ser Ser Val Pro Glu Ile Leu Gln Phe Asn Leu Leu Gly Val Pro 
625                 630                 635                 640 


Leu Val Gly Ala Asp Val Cys Gly Phe Leu Gly Asn Thr Ser Glu Glu 
                645                 650                 655     


Leu Cys Val Arg Trp Thr Gln Leu Gly Ala Phe Tyr Pro Phe Met Arg 
            660                 665                 670         


Asn His Asn Ser Leu Leu Ser Leu Pro Gln Glu Pro Tyr Ser Phe Ser 
        675                 680                 685             


Glu Pro Ala Gln Gln Ala Met Arg Lys Ala Leu Thr Leu Arg Tyr Ala 
    690                 695                 700                 


Leu Leu Pro His Leu Tyr Thr Leu Phe His Gln Ala His Val Ala Gly 
705                 710                 715                 720 


Glu Thr Val Ala Arg Pro Leu Phe Leu Glu Phe Pro Lys Asp Ser Ser 
                725                 730                 735     


Thr Trp Thr Val Asp His Gln Leu Leu Trp Gly Glu Ala Leu Leu Ile 
            740                 745                 750         


Thr Pro Val Leu Gln Ala Gly Lys Ala Glu Val Thr Gly Tyr Phe Pro 
        755                 760                 765             


Leu Gly Thr Trp Tyr Asp Leu Gln Thr Val Pro Val Glu Ala Leu Gly 
    770                 775                 780                 


Ser Leu Pro Pro Pro Pro Ala Ala Pro Arg Glu Pro Ala Ile His Ser 
785                 790                 795                 800 


Glu Gly Gln Trp Val Thr Leu Pro Ala Pro Leu Asp Thr Ile Asn Val 
                805                 810                 815     


His Leu Arg Ala Gly Tyr Ile Ile Pro Leu Gln Gly Pro Gly Leu Thr 
            820                 825                 830         


Thr Thr Glu Ser Arg Gln Gln Pro Met Ala Leu Ala Val Ala Leu Thr 
        835                 840                 845             


Lys Gly Gly Glu Ala Arg Gly Glu Leu Phe Trp Asp Asp Gly Glu Ser 
    850                 855                 860                 


Leu Glu Val Leu Glu Arg Gly Ala Tyr Thr Gln Val Ile Phe Leu Ala 
865                 870                 875                 880 


Arg Asn Asn Thr Ile Val Asn Glu Leu Val Arg Val Thr Ser Glu Gly 
                885                 890                 895     


Ala Gly Leu Gln Leu Gln Lys Val Thr Val Leu Gly Val Ala Thr Ala 
            900                 905                 910         


Pro Gln Gln Val Leu Ser Asn Gly Val Pro Val Ser Asn Phe Thr Tyr 
        915                 920                 925             


Ser Pro Asp Thr Lys Val Leu Asp Ile Cys Val Ser Leu Leu Met Gly 
    930                 935                 940                 


Glu Gln Phe Leu Val Ser Trp Cys 
945                 950         


<210>  19
<211>  556
<212>  PRT
<213>  Homo sapiens

<400>  19

Met Glu Leu Cys Gly Leu Gly Leu Pro Arg Pro Pro Met Leu Leu Ala 
1               5                   10                  15      


Leu Leu Leu Ala Thr Leu Leu Ala Ala Met Leu Ala Leu Leu Thr Gln 
            20                  25                  30          


Val Ala Leu Val Val Gln Val Ala Glu Ala Ala Arg Ala Pro Ser Val 
        35                  40                  45              


Ser Ala Lys Pro Gly Pro Ala Leu Trp Pro Leu Pro Leu Leu Val Lys 
    50                  55                  60                  


Met Thr Pro Asn Leu Leu His Leu Ala Pro Glu Asn Phe Tyr Ile Ser 
65                  70                  75                  80  


His Ser Pro Asn Ser Thr Ala Gly Pro Ser Cys Thr Leu Leu Glu Glu 
                85                  90                  95      


Ala Phe Arg Arg Tyr His Gly Tyr Ile Phe Gly Phe Tyr Lys Trp His 
            100                 105                 110         


His Glu Pro Ala Glu Phe Gln Ala Lys Thr Gln Val Gln Gln Leu Leu 
        115                 120                 125             


Val Ser Ile Thr Leu Gln Ser Glu Cys Asp Ala Phe Pro Asn Ile Ser 
    130                 135                 140                 


Ser Asp Glu Ser Tyr Thr Leu Leu Val Lys Glu Pro Val Ala Val Leu 
145                 150                 155                 160 


Lys Ala Asn Arg Val Trp Gly Ala Leu Arg Gly Leu Glu Thr Phe Ser 
                165                 170                 175     


Gln Leu Val Tyr Gln Asp Ser Tyr Gly Thr Phe Thr Ile Asn Glu Ser 
            180                 185                 190         


Thr Ile Ile Asp Ser Pro Arg Phe Ser His Arg Gly Ile Leu Ile Asp 
        195                 200                 205             


Thr Ser Arg His Tyr Leu Pro Val Lys Ile Ile Leu Lys Thr Leu Asp 
    210                 215                 220                 


Ala Met Ala Phe Asn Lys Phe Asn Val Leu His Trp His Ile Val Asp 
225                 230                 235                 240 


Asp Gln Ser Phe Pro Tyr Gln Ser Ile Thr Phe Pro Glu Leu Ser Asn 
                245                 250                 255     


Lys Gly Ser Tyr Ser Leu Ser His Val Tyr Thr Pro Asn Asp Val Arg 
            260                 265                 270         


Met Val Ile Glu Tyr Ala Arg Leu Arg Gly Ile Arg Val Leu Pro Glu 
        275                 280                 285             


Phe Asp Thr Pro Gly His Thr Leu Ser Trp Gly Lys Gly Gln Lys Asp 
    290                 295                 300                 


Leu Leu Thr Pro Cys Tyr Ser Arg Gln Asn Lys Leu Asp Ser Phe Gly 
305                 310                 315                 320 


Pro Ile Asn Pro Thr Leu Asn Thr Thr Tyr Ser Phe Leu Thr Thr Phe 
                325                 330                 335     


Phe Lys Glu Ile Ser Glu Val Phe Pro Asp Gln Phe Ile His Leu Gly 
            340                 345                 350         


Gly Asp Glu Val Glu Phe Lys Cys Trp Glu Ser Asn Pro Lys Ile Gln 
        355                 360                 365             


Asp Phe Met Arg Gln Lys Gly Phe Gly Thr Asp Phe Lys Lys Leu Glu 
    370                 375                 380                 


Ser Phe Tyr Ile Gln Lys Val Leu Asp Ile Ile Ala Thr Ile Asn Lys 
385                 390                 395                 400 


Gly Ser Ile Val Trp Gln Glu Val Phe Asp Asp Lys Ala Lys Leu Ala 
                405                 410                 415     


Pro Gly Thr Ile Val Glu Val Trp Lys Asp Ser Ala Tyr Pro Glu Glu 
            420                 425                 430         


Leu Ser Arg Val Thr Ala Ser Gly Phe Pro Val Ile Leu Ser Ala Pro 
        435                 440                 445             


Trp Tyr Leu Asp Leu Ile Ser Tyr Gly Gln Asp Trp Arg Lys Tyr Tyr 
    450                 455                 460                 


Lys Val Glu Pro Leu Asp Phe Gly Gly Thr Gln Lys Gln Lys Gln Leu 
465                 470                 475                 480 


Phe Ile Gly Gly Glu Ala Cys Leu Trp Gly Glu Tyr Val Asp Ala Thr 
                485                 490                 495     


Asn Leu Thr Pro Arg Leu Trp Pro Arg Ala Ser Ala Val Gly Glu Arg 
            500                 505                 510         


Leu Trp Ser Ser Lys Asp Val Arg Asp Met Asp Asp Ala Tyr Asp Arg 
        515                 520                 525             


Leu Thr Arg His Arg Cys Arg Met Val Glu Arg Gly Ile Ala Ala Gln 
    530                 535                 540                 


Pro Leu Tyr Ala Gly Tyr Cys Asn His Glu Asn Met 
545                 550                 555     


<210>  20
<211>  663
<212>  PRT
<213>  Homo sapiens

<400>  20

Met Thr Gly Ala Arg Ala Ser Ala Ala Glu Gln Arg Arg Ala Gly Arg 
1               5                   10                  15      


Ser Gly Gln Ala Arg Ala Ala Glu Arg Ala Ala Gly Met Ser Gly Ala 
            20                  25                  30          


Gly Arg Ala Leu Ala Ala Leu Leu Leu Ala Ala Ser Val Leu Ser Ala 
        35                  40                  45              


Ala Leu Leu Ala Pro Gly Gly Ser Ser Gly Arg Asp Ala Gln Ala Ala 
    50                  55                  60                  


Pro Pro Arg Asp Leu Asp Lys Lys Arg His Ala Glu Leu Lys Met Asp 
65                  70                  75                  80  


Gln Ala Leu Leu Leu Ile His Asn Glu Leu Leu Trp Thr Asn Leu Thr 
                85                  90                  95      


Val Tyr Trp Lys Ser Glu Cys Cys Tyr His Cys Leu Phe Gln Val Leu 
            100                 105                 110         


Val Asn Val Pro Gln Ser Pro Lys Ala Gly Lys Pro Ser Ala Ala Ala 
        115                 120                 125             


Ala Ser Val Ser Thr Gln His Gly Ser Ile Leu Gln Leu Asn Asp Thr 
    130                 135                 140                 


Leu Glu Glu Lys Glu Val Cys Arg Leu Glu Tyr Arg Phe Gly Glu Phe 
145                 150                 155                 160 


Gly Asn Tyr Ser Leu Leu Val Lys Asn Ile His Asn Gly Val Ser Glu 
                165                 170                 175     


Ile Ala Cys Asp Leu Ala Val Asn Glu Asp Pro Val Asp Ser Asn Leu 
            180                 185                 190         


Pro Val Ser Ile Ala Phe Leu Ile Gly Leu Ala Val Ile Ile Val Ile 
        195                 200                 205             


Ser Phe Leu Arg Leu Leu Leu Ser Leu Asp Asp Phe Asn Asn Trp Ile 
    210                 215                 220                 


Ser Lys Ala Ile Ser Ser Arg Glu Thr Asp Arg Leu Ile Asn Ser Glu 
225                 230                 235                 240 


Leu Gly Ser Pro Ser Arg Thr Asp Pro Leu Asp Gly Asp Val Gln Pro 
                245                 250                 255     


Ala Thr Trp Arg Leu Ser Ala Leu Pro Pro Arg Leu Arg Ser Val Asp 
            260                 265                 270         


Thr Phe Arg Gly Ile Ala Leu Ile Leu Met Val Phe Val Asn Tyr Gly 
        275                 280                 285             


Gly Gly Lys Tyr Trp Tyr Phe Lys His Ala Ser Trp Asn Gly Leu Thr 
    290                 295                 300                 


Val Ala Asp Leu Val Phe Pro Trp Phe Val Phe Ile Met Gly Ser Ser 
305                 310                 315                 320 


Ile Phe Leu Ser Met Thr Ser Ile Leu Gln Arg Gly Cys Ser Lys Phe 
                325                 330                 335     


Arg Leu Leu Gly Lys Ile Ala Trp Arg Ser Phe Leu Leu Ile Cys Ile 
            340                 345                 350         


Gly Ile Ile Ile Val Asn Pro Asn Tyr Cys Leu Gly Pro Leu Ser Trp 
        355                 360                 365             


Asp Lys Val Arg Ile Pro Gly Val Leu Gln Arg Leu Gly Val Thr Tyr 
    370                 375                 380                 


Phe Val Val Ala Val Leu Glu Leu Leu Phe Ala Lys Pro Val Pro Glu 
385                 390                 395                 400 


His Cys Ala Ser Glu Arg Ser Cys Leu Ser Leu Arg Asp Ile Thr Ser 
                405                 410                 415     


Ser Trp Pro Gln Trp Leu Leu Ile Leu Val Leu Glu Gly Leu Trp Leu 
            420                 425                 430         


Gly Leu Thr Phe Leu Leu Pro Val Pro Gly Cys Pro Thr Gly Tyr Leu 
        435                 440                 445             


Gly Pro Gly Gly Ile Gly Asp Phe Gly Lys Tyr Pro Asn Cys Thr Gly 
    450                 455                 460                 


Gly Ala Ala Gly Tyr Ile Asp Arg Leu Leu Leu Gly Asp Asp His Leu 
465                 470                 475                 480 


Tyr Gln His Pro Ser Ser Ala Val Leu Tyr His Thr Glu Val Ala Tyr 
                485                 490                 495     


Asp Pro Glu Gly Ile Leu Gly Thr Ile Asn Ser Ile Val Met Ala Phe 
            500                 505                 510         


Leu Gly Val Gln Ala Gly Lys Ile Leu Leu Tyr Tyr Lys Ala Arg Thr 
        515                 520                 525             


Lys Asp Ile Leu Ile Arg Phe Thr Ala Trp Cys Cys Ile Leu Gly Leu 
    530                 535                 540                 


Ile Ser Val Ala Leu Thr Lys Val Ser Glu Asn Glu Gly Phe Ile Pro 
545                 550                 555                 560 


Val Asn Lys Asn Leu Trp Ser Leu Ser Tyr Val Thr Thr Leu Ser Ser 
                565                 570                 575     


Phe Ala Phe Phe Ile Leu Leu Val Leu Tyr Pro Val Val Asp Val Lys 
            580                 585                 590         


Gly Leu Trp Thr Gly Thr Pro Phe Phe Tyr Pro Gly Met Asn Ser Ile 
        595                 600                 605             


Leu Val Tyr Val Gly His Glu Val Phe Glu Asn Tyr Phe Pro Phe Gln 
    610                 615                 620                 


Trp Lys Leu Lys Asp Asn Gln Ser His Lys Glu His Leu Thr Gln Asn 
625                 630                 635                 640 


Ile Val Ala Thr Ala Leu Trp Val Leu Ile Ala Tyr Ile Leu Tyr Arg 
                645                 650                 655     


Lys Lys Ile Phe Trp Lys Ile 
            660             


<210>  21
<211>  743
<212>  PRT
<213>  Homo sapiens

<400>  21

Met Glu Ala Val Ala Val Ala Ala Ala Val Gly Val Leu Leu Leu Ala 
1               5                   10                  15      


Gly Ala Gly Gly Ala Ala Gly Asp Glu Ala Arg Glu Ala Ala Ala Val 
            20                  25                  30          


Arg Ala Leu Val Ala Arg Leu Leu Gly Pro Gly Pro Ala Ala Asp Phe 
        35                  40                  45              


Ser Val Ser Val Glu Arg Ala Leu Ala Ala Lys Pro Gly Leu Asp Thr 
    50                  55                  60                  


Tyr Ser Leu Gly Gly Gly Gly Ala Ala Arg Val Arg Val Arg Gly Ser 
65                  70                  75                  80  


Thr Gly Val Ala Ala Ala Ala Gly Leu His Arg Tyr Leu Arg Asp Phe 
                85                  90                  95      


Cys Gly Cys His Val Ala Trp Ser Gly Ser Gln Leu Arg Leu Pro Arg 
            100                 105                 110         


Pro Leu Pro Ala Val Pro Gly Glu Leu Thr Glu Ala Thr Pro Asn Arg 
        115                 120                 125             


Tyr Arg Tyr Tyr Gln Asn Val Cys Thr Gln Ser Tyr Ser Phe Val Trp 
    130                 135                 140                 


Trp Asp Trp Ala Arg Trp Glu Arg Glu Ile Asp Trp Met Ala Leu Asn 
145                 150                 155                 160 


Gly Ile Asn Leu Ala Leu Ala Trp Ser Gly Gln Glu Ala Ile Trp Gln 
                165                 170                 175     


Arg Val Tyr Leu Ala Leu Gly Leu Thr Gln Ala Glu Ile Asn Glu Phe 
            180                 185                 190         


Phe Thr Gly Pro Ala Phe Leu Ala Trp Gly Arg Met Gly Asn Leu His 
        195                 200                 205             


Thr Trp Asp Gly Pro Leu Pro Pro Ser Trp His Ile Lys Gln Leu Tyr 
    210                 215                 220                 


Leu Gln His Arg Val Leu Asp Gln Met Arg Ser Phe Gly Met Thr Pro 
225                 230                 235                 240 


Val Leu Pro Ala Phe Ala Gly His Val Pro Glu Ala Val Thr Arg Val 
                245                 250                 255     


Phe Pro Gln Val Asn Val Thr Lys Met Gly Ser Trp Gly His Phe Asn 
            260                 265                 270         


Cys Ser Tyr Ser Cys Ser Phe Leu Leu Ala Pro Glu Asp Pro Ile Phe 
        275                 280                 285             


Pro Ile Ile Gly Ser Leu Phe Leu Arg Glu Leu Ile Lys Glu Phe Gly 
    290                 295                 300                 


Thr Asp His Ile Tyr Gly Ala Asp Thr Phe Asn Glu Met Gln Pro Pro 
305                 310                 315                 320 


Ser Ser Glu Pro Ser Tyr Leu Ala Ala Ala Thr Thr Ala Val Tyr Glu 
                325                 330                 335     


Ala Met Thr Ala Val Asp Thr Glu Ala Val Trp Leu Leu Gln Gly Trp 
            340                 345                 350         


Leu Phe Gln His Gln Pro Gln Phe Trp Gly Pro Ala Gln Ile Arg Ala 
        355                 360                 365             


Val Leu Gly Ala Val Pro Arg Gly Arg Leu Leu Val Leu Asp Leu Phe 
    370                 375                 380                 


Ala Glu Ser Gln Pro Val Tyr Thr Arg Thr Ala Ser Phe Gln Gly Gln 
385                 390                 395                 400 


Pro Phe Ile Trp Cys Met Leu His Asn Phe Gly Gly Asn His Gly Leu 
                405                 410                 415     


Phe Gly Ala Leu Glu Ala Val Asn Gly Gly Pro Glu Ala Ala Arg Leu 
            420                 425                 430         


Phe Pro Asn Ser Thr Met Val Gly Thr Gly Met Ala Pro Glu Gly Ile 
        435                 440                 445             


Ser Gln Asn Glu Val Val Tyr Ser Leu Met Ala Glu Leu Gly Trp Arg 
    450                 455                 460                 


Lys Asp Pro Val Pro Asp Leu Ala Ala Trp Val Thr Ser Phe Ala Ala 
465                 470                 475                 480 


Arg Arg Tyr Gly Val Ser His Pro Asp Ala Gly Ala Ala Trp Arg Leu 
                485                 490                 495     


Leu Leu Arg Ser Val Tyr Asn Cys Ser Gly Glu Ala Cys Arg Gly His 
            500                 505                 510         


Asn Arg Ser Pro Leu Val Arg Arg Pro Ser Leu Gln Met Asn Thr Ser 
        515                 520                 525             


Ile Trp Tyr Asn Arg Ser Asp Val Phe Glu Ala Trp Arg Leu Leu Leu 
    530                 535                 540                 


Thr Ser Ala Pro Ser Leu Ala Thr Ser Pro Ala Phe Arg Tyr Asp Leu 
545                 550                 555                 560 


Leu Asp Leu Thr Arg Gln Ala Val Gln Glu Leu Val Ser Leu Tyr Tyr 
                565                 570                 575     


Glu Glu Ala Arg Ser Ala Tyr Leu Ser Lys Glu Leu Ala Ser Leu Leu 
            580                 585                 590         


Arg Ala Gly Gly Val Leu Ala Tyr Glu Leu Leu Pro Ala Leu Asp Glu 
        595                 600                 605             


Val Leu Ala Ser Asp Ser Arg Phe Leu Leu Gly Ser Trp Leu Glu Gln 
    610                 615                 620                 


Ala Arg Ala Ala Ala Val Ser Glu Ala Glu Ala Asp Phe Tyr Glu Gln 
625                 630                 635                 640 


Asn Ser Arg Tyr Gln Leu Thr Leu Trp Gly Pro Glu Gly Asn Ile Leu 
                645                 650                 655     


Asp Tyr Ala Asn Lys Gln Leu Ala Gly Leu Val Ala Asn Tyr Tyr Thr 
            660                 665                 670         


Pro Arg Trp Arg Leu Phe Leu Glu Ala Leu Val Asp Ser Val Ala Gln 
        675                 680                 685             


Gly Ile Pro Phe Gln Gln His Gln Phe Asp Lys Asn Val Phe Gln Leu 
    690                 695                 700                 


Glu Gln Ala Phe Val Leu Ser Lys Gln Arg Tyr Pro Ser Gln Pro Arg 
705                 710                 715                 720 


Gly Asp Thr Val Asp Leu Ala Lys Lys Ile Phe Leu Lys Tyr Tyr Pro 
                725                 730                 735     


Arg Trp Val Ala Gly Ser Trp 
            740             


<210>  22
<211>  663
<212>  PRT
<213>  Homo sapiens

<400>  22

Met Thr Gly Ala Arg Ala Ser Ala Ala Glu Gln Arg Arg Ala Gly Arg 
1               5                   10                  15      


Ser Gly Gln Ala Arg Ala Ala Glu Arg Ala Ala Gly Met Ser Gly Ala 
            20                  25                  30          


Gly Arg Ala Leu Ala Ala Leu Leu Leu Ala Ala Ser Val Leu Ser Ala 
        35                  40                  45              


Ala Leu Leu Ala Pro Gly Gly Ser Ser Gly Arg Asp Ala Gln Ala Ala 
    50                  55                  60                  


Pro Pro Arg Asp Leu Asp Lys Lys Arg His Ala Glu Leu Lys Met Asp 
65                  70                  75                  80  


Gln Ala Leu Leu Leu Ile His Asn Glu Leu Leu Trp Thr Asn Leu Thr 
                85                  90                  95      


Val Tyr Trp Lys Ser Glu Cys Cys Tyr His Cys Leu Phe Gln Val Leu 
            100                 105                 110         


Val Asn Val Pro Gln Ser Pro Lys Ala Gly Lys Pro Ser Ala Ala Ala 
        115                 120                 125             


Ala Ser Val Ser Thr Gln His Gly Ser Ile Leu Gln Leu Asn Asp Thr 
    130                 135                 140                 


Leu Glu Glu Lys Glu Val Cys Arg Leu Glu Tyr Arg Phe Gly Glu Phe 
145                 150                 155                 160 


Gly Asn Tyr Ser Leu Leu Val Lys Asn Ile His Asn Gly Val Ser Glu 
                165                 170                 175     


Ile Ala Cys Asp Leu Ala Val Asn Glu Asp Pro Val Asp Ser Asn Leu 
            180                 185                 190         


Pro Val Ser Ile Ala Phe Leu Ile Gly Leu Ala Val Ile Ile Val Ile 
        195                 200                 205             


Ser Phe Leu Arg Leu Leu Leu Ser Leu Asp Asp Phe Asn Asn Trp Ile 
    210                 215                 220                 


Ser Lys Ala Ile Ser Ser Arg Glu Thr Asp Arg Leu Ile Asn Ser Glu 
225                 230                 235                 240 


Leu Gly Ser Pro Ser Arg Thr Asp Pro Leu Asp Gly Asp Val Gln Pro 
                245                 250                 255     


Ala Thr Trp Arg Leu Ser Ala Leu Pro Pro Arg Leu Arg Ser Val Asp 
            260                 265                 270         


Thr Phe Arg Gly Ile Ala Leu Ile Leu Met Val Phe Val Asn Tyr Gly 
        275                 280                 285             


Gly Gly Lys Tyr Trp Tyr Phe Lys His Ala Ser Trp Asn Gly Leu Thr 
    290                 295                 300                 


Val Ala Asp Leu Val Phe Pro Trp Phe Val Phe Ile Met Gly Ser Ser 
305                 310                 315                 320 


Ile Phe Leu Ser Met Thr Ser Ile Leu Gln Arg Gly Cys Ser Lys Phe 
                325                 330                 335     


Arg Leu Leu Gly Lys Ile Ala Trp Arg Ser Phe Leu Leu Ile Cys Ile 
            340                 345                 350         


Gly Ile Ile Ile Val Asn Pro Asn Tyr Cys Leu Gly Pro Leu Ser Trp 
        355                 360                 365             


Asp Lys Val Arg Ile Pro Gly Val Leu Gln Arg Leu Gly Val Thr Tyr 
    370                 375                 380                 


Phe Val Val Ala Val Leu Glu Leu Leu Phe Ala Lys Pro Val Pro Glu 
385                 390                 395                 400 


His Cys Ala Ser Glu Arg Ser Cys Leu Ser Leu Arg Asp Ile Thr Ser 
                405                 410                 415     


Ser Trp Pro Gln Trp Leu Leu Ile Leu Val Leu Glu Gly Leu Trp Leu 
            420                 425                 430         


Gly Leu Thr Phe Leu Leu Pro Val Pro Gly Cys Pro Thr Gly Tyr Leu 
        435                 440                 445             


Gly Pro Gly Gly Ile Gly Asp Phe Gly Lys Tyr Pro Asn Cys Thr Gly 
    450                 455                 460                 


Gly Ala Ala Gly Tyr Ile Asp Arg Leu Leu Leu Gly Asp Asp His Leu 
465                 470                 475                 480 


Tyr Gln His Pro Ser Ser Ala Val Leu Tyr His Thr Glu Val Ala Tyr 
                485                 490                 495     


Asp Pro Glu Gly Ile Leu Gly Thr Ile Asn Ser Ile Val Met Ala Phe 
            500                 505                 510         


Leu Gly Val Gln Ala Gly Lys Ile Leu Leu Tyr Tyr Lys Ala Arg Thr 
        515                 520                 525             


Lys Asp Ile Leu Ile Arg Phe Thr Ala Trp Cys Cys Ile Leu Gly Leu 
    530                 535                 540                 


Ile Ser Val Ala Leu Thr Lys Val Ser Glu Asn Glu Gly Phe Ile Pro 
545                 550                 555                 560 


Val Asn Lys Asn Leu Trp Ser Leu Ser Tyr Val Thr Thr Leu Ser Ser 
                565                 570                 575     


Phe Ala Phe Phe Ile Leu Leu Val Leu Tyr Pro Val Val Asp Val Lys 
            580                 585                 590         


Gly Leu Trp Thr Gly Thr Pro Phe Phe Tyr Pro Gly Met Asn Ser Ile 
        595                 600                 605             


Leu Val Tyr Val Gly His Glu Val Phe Glu Asn Tyr Phe Pro Phe Gln 
    610                 615                 620                 


Trp Lys Leu Lys Asp Asn Gln Ser His Lys Glu His Leu Thr Gln Asn 
625                 630                 635                 640 


Ile Val Ala Thr Ala Leu Trp Val Leu Ile Ala Tyr Ile Leu Tyr Arg 
                645                 650                 655     


Lys Lys Ile Phe Trp Lys Ile 
            660             


<210>  23
<211>  552
<212>  PRT
<213>  Homo sapiens

<400>  23

Met Arg Leu Leu Pro Leu Ala Pro Gly Arg Leu Arg Arg Gly Ser Pro 
1               5                   10                  15      


Arg His Leu Pro Ser Cys Ser Pro Ala Leu Leu Leu Leu Val Leu Gly 
            20                  25                  30          


Gly Cys Leu Gly Val Phe Gly Val Ala Ala Gly Thr Arg Arg Pro Asn 
        35                  40                  45              


Val Val Leu Leu Leu Thr Asp Asp Gln Asp Glu Val Leu Gly Gly Met 
    50                  55                  60                  


Thr Pro Leu Lys Lys Thr Lys Ala Leu Ile Gly Glu Met Gly Met Thr 
65                  70                  75                  80  


Phe Ser Ser Ala Tyr Val Pro Ser Ala Leu Cys Cys Pro Ser Arg Ala 
                85                  90                  95      


Ser Ile Leu Thr Gly Lys Tyr Pro His Asn His His Val Val Asn Asn 
            100                 105                 110         


Thr Leu Glu Gly Asn Cys Ser Ser Lys Ser Trp Gln Lys Ile Gln Glu 
        115                 120                 125             


Pro Asn Thr Phe Pro Ala Ile Leu Arg Ser Met Cys Gly Tyr Gln Thr 
    130                 135                 140                 


Phe Phe Ala Gly Lys Tyr Leu Asn Glu Tyr Gly Ala Pro Asp Ala Gly 
145                 150                 155                 160 


Gly Leu Glu His Val Pro Leu Gly Trp Ser Tyr Trp Tyr Ala Leu Glu 
                165                 170                 175     


Lys Asn Ser Lys Tyr Tyr Asn Tyr Thr Leu Ser Ile Asn Gly Lys Ala 
            180                 185                 190         


Arg Lys His Gly Glu Asn Tyr Ser Val Asp Tyr Leu Thr Asp Val Leu 
        195                 200                 205             


Ala Asn Val Ser Leu Asp Phe Leu Asp Tyr Lys Ser Asn Phe Glu Pro 
    210                 215                 220                 


Phe Phe Met Met Ile Ala Thr Pro Ala Pro His Ser Pro Trp Thr Ala 
225                 230                 235                 240 


Ala Pro Gln Tyr Gln Lys Ala Phe Gln Asn Val Phe Ala Pro Arg Asn 
                245                 250                 255     


Lys Asn Phe Asn Ile His Gly Thr Asn Lys His Trp Leu Ile Arg Gln 
            260                 265                 270         


Ala Lys Thr Pro Met Thr Asn Ser Ser Ile Gln Phe Leu Asp Asn Ala 
        275                 280                 285             


Phe Arg Lys Arg Trp Gln Thr Leu Leu Ser Val Asp Asp Leu Val Glu 
    290                 295                 300                 


Lys Leu Val Lys Arg Leu Glu Phe Thr Gly Glu Leu Asn Asn Thr Tyr 
305                 310                 315                 320 


Ile Phe Tyr Thr Ser Asp Asn Gly Tyr His Thr Gly Gln Phe Ser Leu 
                325                 330                 335     


Pro Ile Asp Lys Arg Gln Leu Tyr Glu Phe Asp Ile Lys Val Pro Leu 
            340                 345                 350         


Leu Val Arg Gly Pro Gly Ile Lys Pro Asn Gln Thr Ser Lys Met Leu 
        355                 360                 365             


Val Ala Asn Ile Asp Leu Gly Pro Thr Ile Leu Asp Ile Ala Gly Tyr 
    370                 375                 380                 


Asp Leu Asn Lys Thr Gln Met Asp Gly Met Ser Leu Leu Pro Ile Leu 
385                 390                 395                 400 


Arg Gly Ala Ser Asn Leu Thr Trp Arg Ser Asp Val Leu Val Glu Tyr 
                405                 410                 415     


Gln Gly Glu Gly Arg Asn Val Thr Asp Pro Thr Cys Pro Ser Leu Ser 
            420                 425                 430         


Pro Gly Val Ser Gln Cys Phe Pro Asp Cys Val Cys Glu Asp Ala Tyr 
        435                 440                 445             


Asn Asn Thr Tyr Ala Cys Val Arg Thr Met Ser Ala Leu Trp Asn Leu 
    450                 455                 460                 


Gln Tyr Cys Glu Phe Asp Asp Gln Glu Val Phe Val Glu Val Tyr Asn 
465                 470                 475                 480 


Leu Thr Ala Asp Pro Asp Gln Ile Thr Asn Ile Ala Lys Thr Ile Asp 
                485                 490                 495     


Pro Glu Leu Leu Gly Lys Met Asn Tyr Arg Leu Met Met Leu Gln Ser 
            500                 505                 510         


Cys Ser Gly Pro Thr Cys Arg Thr Pro Gly Val Phe Asp Pro Gly Tyr 
        515                 520                 525             


Arg Phe Asp Pro Arg Leu Met Phe Ser Asn Arg Gly Ser Val Arg Thr 
    530                 535                 540                 


Arg Arg Phe Ser Lys His Leu Leu 
545                 550         


<210>  24
<211>  411
<212>  PRT
<213>  Homo sapiens

<400>  24

Met Leu Leu Lys Thr Val Leu Leu Leu Gly His Val Ala Gln Val Leu 
1               5                   10                  15      


Met Leu Asp Asn Gly Leu Leu Gln Thr Pro Pro Met Gly Trp Leu Ala 
            20                  25                  30          


Trp Glu Arg Phe Arg Cys Asn Ile Asn Cys Asp Glu Asp Pro Lys Asn 
        35                  40                  45              


Cys Ile Ser Glu Gln Leu Phe Met Glu Met Ala Asp Arg Met Ala Gln 
    50                  55                  60                  


Asp Gly Trp Arg Asp Met Gly Tyr Thr Tyr Leu Asn Ile Asp Asp Cys 
65                  70                  75                  80  


Trp Ile Gly Gly Arg Asp Ala Ser Gly Arg Leu Met Pro Asp Pro Lys 
                85                  90                  95      


Arg Phe Pro His Gly Ile Pro Phe Leu Ala Asp Tyr Val His Ser Leu 
            100                 105                 110         


Gly Leu Lys Leu Gly Ile Tyr Ala Asp Met Gly Asn Phe Thr Cys Met 
        115                 120                 125             


Gly Tyr Pro Gly Thr Thr Leu Asp Lys Val Val Gln Asp Ala Gln Thr 
    130                 135                 140                 


Phe Ala Glu Trp Lys Val Asp Met Leu Lys Leu Asp Gly Cys Phe Ser 
145                 150                 155                 160 


Thr Pro Glu Glu Arg Ala Gln Gly Tyr Pro Lys Met Ala Ala Ala Leu 
                165                 170                 175     


Asn Ala Thr Gly Arg Pro Ile Ala Phe Ser Cys Ser Trp Pro Ala Tyr 
            180                 185                 190         


Glu Gly Gly Leu Pro Pro Arg Val Asn Tyr Ser Leu Leu Ala Asp Ile 
        195                 200                 205             


Cys Asn Leu Trp Arg Asn Tyr Asp Asp Ile Gln Asp Ser Trp Trp Ser 
    210                 215                 220                 


Val Leu Ser Ile Leu Asn Trp Phe Val Glu His Gln Asp Ile Leu Gln 
225                 230                 235                 240 


Pro Val Ala Gly Pro Gly His Trp Asn Asp Pro Asp Met Leu Leu Ile 
                245                 250                 255     


Gly Asn Phe Gly Leu Ser Leu Glu Gln Ser Arg Ala Gln Met Ala Leu 
            260                 265                 270         


Trp Thr Val Leu Ala Ala Pro Leu Leu Met Ser Thr Asp Leu Arg Thr 
        275                 280                 285             


Ile Ser Ala Gln Asn Met Asp Ile Leu Gln Asn Pro Leu Met Ile Lys 
    290                 295                 300                 


Ile Asn Gln Asp Pro Leu Gly Ile Gln Gly Arg Arg Ile His Lys Glu 
305                 310                 315                 320 


Lys Ser Leu Ile Glu Val Tyr Met Arg Pro Leu Ser Asn Lys Ala Ser 
                325                 330                 335     


Ala Leu Val Phe Phe Ser Cys Arg Thr Asp Met Pro Tyr Arg Tyr His 
            340                 345                 350         


Ser Ser Leu Gly Gln Leu Asn Phe Thr Gly Ser Val Ile Tyr Glu Ala 
        355                 360                 365             


Gln Asp Val Tyr Ser Gly Asp Ile Ile Ser Gly Leu Arg Asp Glu Thr 
    370                 375                 380                 


Asn Phe Thr Val Ile Ile Asn Pro Ser Gly Val Val Met Trp Tyr Leu 
385                 390                 395                 400 


Tyr Pro Ile Lys Asn Leu Glu Met Ser Gln Gln 
                405                 410     


<210>  25
<211>  415
<212>  PRT
<213>  Homo sapiens

<400>  25

Met Thr Gly Glu Arg Pro Ser Thr Ala Leu Pro Asp Arg Arg Trp Gly 
1               5                   10                  15      


Pro Arg Ile Leu Gly Phe Trp Gly Gly Cys Arg Val Trp Val Phe Ala 
            20                  25                  30          


Ala Ile Phe Leu Leu Leu Ser Leu Ala Ala Ser Trp Ser Lys Ala Glu 
        35                  40                  45              


Asn Asp Phe Gly Leu Val Gln Pro Leu Val Thr Met Glu Gln Leu Leu 
    50                  55                  60                  


Trp Val Ser Gly Arg Gln Ile Gly Ser Val Asp Thr Phe Arg Ile Pro 
65                  70                  75                  80  


Leu Ile Thr Ala Thr Pro Arg Gly Thr Leu Leu Ala Phe Ala Glu Ala 
                85                  90                  95      


Arg Lys Met Ser Ser Ser Asp Glu Gly Ala Lys Phe Ile Ala Leu Arg 
            100                 105                 110         


Arg Ser Met Asp Gln Gly Ser Thr Trp Ser Pro Thr Ala Phe Ile Val 
        115                 120                 125             


Asn Asp Gly Asp Val Pro Asp Gly Leu Asn Leu Gly Ala Val Val Ser 
    130                 135                 140                 


Asp Val Glu Thr Gly Val Val Phe Leu Phe Tyr Ser Leu Cys Ala His 
145                 150                 155                 160 


Lys Ala Gly Cys Gln Val Ala Ser Thr Met Leu Val Trp Ser Lys Asp 
                165                 170                 175     


Asp Gly Val Ser Trp Ser Thr Pro Arg Asn Leu Ser Leu Asp Ile Gly 
            180                 185                 190         


Thr Glu Val Phe Ala Pro Gly Pro Gly Ser Gly Ile Gln Lys Gln Arg 
        195                 200                 205             


Glu Pro Arg Lys Gly Arg Leu Ile Val Cys Gly His Gly Thr Leu Glu 
    210                 215                 220                 


Arg Asp Gly Val Phe Cys Leu Leu Ser Asp Asp His Gly Ala Ser Trp 
225                 230                 235                 240 


Arg Tyr Gly Ser Gly Val Ser Gly Ile Pro Tyr Gly Gln Pro Lys Gln 
                245                 250                 255     


Glu Asn Asp Phe Asn Pro Asp Glu Cys Gln Pro Tyr Glu Leu Pro Asp 
            260                 265                 270         


Gly Ser Val Val Ile Asn Ala Arg Asn Gln Asn Asn Tyr His Cys His 
        275                 280                 285             


Cys Arg Ile Val Leu Arg Ser Tyr Asp Ala Cys Asp Thr Leu Arg Pro 
    290                 295                 300                 


Arg Asp Val Thr Phe Asp Pro Glu Leu Val Asp Pro Val Val Ala Ala 
305                 310                 315                 320 


Gly Ala Val Val Thr Ser Ser Gly Ile Val Phe Phe Ser Asn Pro Ala 
                325                 330                 335     


His Pro Glu Phe Arg Val Asn Leu Thr Leu Arg Trp Ser Phe Ser Asn 
            340                 345                 350         


Gly Thr Ser Trp Arg Lys Glu Thr Val Gln Leu Trp Pro Gly Pro Ser 
        355                 360                 365             


Gly Tyr Ser Ser Leu Ala Thr Leu Glu Gly Ser Met Asp Gly Glu Glu 
    370                 375                 380                 


Gln Ala Pro Gln Leu Tyr Val Leu Tyr Glu Lys Gly Arg Asn His Tyr 
385                 390                 395                 400 


Thr Glu Ser Ile Ser Val Ala Lys Ile Ser Val Tyr Gly Thr Leu 
                405                 410                 415 


<210>  26
<211>  651
<212>  PRT
<213>  Homo sapiens

<400>  26

Met Ala Arg Gly Ser Ala Val Ala Trp Ala Ala Leu Gly Pro Leu Leu 
1               5                   10                  15      


Trp Gly Cys Ala Leu Gly Leu Gln Gly Gly Met Leu Tyr Pro Gln Glu 
            20                  25                  30          


Ser Pro Ser Arg Glu Cys Lys Glu Leu Asp Gly Leu Trp Ser Phe Arg 
        35                  40                  45              


Ala Asp Phe Ser Asp Asn Arg Arg Arg Gly Phe Glu Glu Gln Trp Tyr 
    50                  55                  60                  


Arg Arg Pro Leu Trp Glu Ser Gly Pro Thr Val Asp Met Pro Val Pro 
65                  70                  75                  80  


Ser Ser Phe Asn Asp Ile Ser Gln Asp Trp Arg Leu Arg His Phe Val 
                85                  90                  95      


Gly Trp Val Trp Tyr Glu Arg Glu Val Ile Leu Pro Glu Arg Trp Thr 
            100                 105                 110         


Gln Asp Leu Arg Thr Arg Val Val Leu Arg Ile Gly Ser Ala His Ser 
        115                 120                 125             


Tyr Ala Ile Val Trp Val Asn Gly Val Asp Thr Leu Glu His Glu Gly 
    130                 135                 140                 


Gly Tyr Leu Pro Phe Glu Ala Asp Ile Ser Asn Leu Val Gln Val Gly 
145                 150                 155                 160 


Pro Leu Pro Ser Arg Leu Arg Ile Thr Ile Ala Ile Asn Asn Thr Leu 
                165                 170                 175     


Thr Pro Thr Thr Leu Pro Pro Gly Thr Ile Gln Tyr Leu Thr Asp Thr 
            180                 185                 190         


Ser Lys Tyr Pro Lys Gly Tyr Phe Val Gln Asn Thr Tyr Phe Asp Phe 
        195                 200                 205             


Phe Asn Tyr Ala Gly Leu Gln Arg Ser Val Leu Leu Tyr Thr Thr Pro 
    210                 215                 220                 


Thr Thr Tyr Ile Asp Asp Ile Thr Val Thr Thr Ser Val Glu Gln Asp 
225                 230                 235                 240 


Ser Gly Leu Val Asn Tyr Gln Ile Ser Val Lys Gly Ser Asn Leu Phe 
                245                 250                 255     


Lys Leu Glu Val Arg Leu Leu Asp Ala Glu Asn Lys Val Val Ala Asn 
            260                 265                 270         


Gly Thr Gly Thr Gln Gly Gln Leu Lys Val Pro Gly Val Ser Leu Trp 
        275                 280                 285             


Trp Pro Tyr Leu Met His Glu Arg Pro Ala Tyr Leu Tyr Ser Leu Glu 
    290                 295                 300                 


Val Gln Leu Thr Ala Gln Thr Ser Leu Gly Pro Val Ser Asp Phe Tyr 
305                 310                 315                 320 


Thr Leu Pro Val Gly Ile Arg Thr Val Ala Val Thr Lys Ser Gln Phe 
                325                 330                 335     


Leu Ile Asn Gly Lys Pro Phe Tyr Phe His Gly Val Asn Lys His Glu 
            340                 345                 350         


Asp Ala Asp Ile Arg Gly Lys Gly Phe Asp Trp Pro Leu Leu Val Lys 
        355                 360                 365             


Asp Phe Asn Leu Leu Arg Trp Leu Gly Ala Asn Ala Phe Arg Thr Ser 
    370                 375                 380                 


His Tyr Pro Tyr Ala Glu Glu Val Met Gln Met Cys Asp Arg Tyr Gly 
385                 390                 395                 400 


Ile Val Val Ile Asp Glu Cys Pro Gly Val Gly Leu Ala Leu Pro Gln 
                405                 410                 415     


Phe Phe Asn Asn Val Ser Leu His His His Met Gln Val Met Glu Glu 
            420                 425                 430         


Val Val Arg Arg Asp Lys Asn His Pro Ala Val Val Met Trp Ser Val 
        435                 440                 445             


Ala Asn Glu Pro Ala Ser His Leu Glu Ser Ala Gly Tyr Tyr Leu Lys 
    450                 455                 460                 


Met Val Ile Ala His Thr Lys Ser Leu Asp Pro Ser Arg Ser Val Thr 
465                 470                 475                 480 


Phe Val Ser Asn Ser Asn Tyr Ala Ala Asp Lys Gly Ala Pro Tyr Val 
                485                 490                 495     


Asp Val Ile Cys Leu Asn Ser Tyr Tyr Ser Trp Tyr His Asp Tyr Gly 
            500                 505                 510         


His Leu Glu Leu Ile Gln Leu Gln Leu Ala Thr Gln Phe Glu Asn Trp 
        515                 520                 525             


Tyr Lys Lys Tyr Gln Lys Pro Ile Ile Gln Ser Glu Tyr Gly Ala Glu 
    530                 535                 540                 


Thr Ile Ala Gly Phe His Gln Asp Pro Pro Leu Met Phe Thr Glu Glu 
545                 550                 555                 560 


Tyr Gln Lys Ser Leu Leu Glu Gln Tyr His Leu Gly Leu Asp Gln Lys 
                565                 570                 575     


Arg Arg Lys Tyr Val Val Gly Glu Leu Ile Trp Asn Phe Ala Asp Phe 
            580                 585                 590         


Met Thr Glu Gln Ser Pro Thr Arg Val Leu Gly Asn Lys Lys Gly Ile 
        595                 600                 605             


Phe Thr Arg Gln Arg Gln Pro Lys Ser Ala Ala Phe Leu Leu Arg Glu 
    610                 615                 620                 


Arg Tyr Trp Lys Ile Ala Asn Glu Thr Arg Tyr Pro His Ser Val Ala 
625                 630                 635                 640 


Lys Ser Gln Cys Leu Glu Asn Ser Pro Phe Thr 
                645                 650     


<210>  27
<211>  556
<212>  PRT
<213>  Homo sapiens

<400>  27

Met Glu Leu Cys Gly Leu Gly Leu Pro Arg Pro Pro Met Leu Leu Ala 
1               5                   10                  15      


Leu Leu Leu Ala Thr Leu Leu Ala Ala Met Leu Ala Leu Leu Thr Gln 
            20                  25                  30          


Val Ala Leu Val Val Gln Val Ala Glu Ala Ala Arg Ala Pro Ser Val 
        35                  40                  45              


Ser Ala Lys Pro Gly Pro Ala Leu Trp Pro Leu Pro Leu Leu Val Lys 
    50                  55                  60                  


Met Thr Pro Asn Leu Leu His Leu Ala Pro Glu Asn Phe Tyr Ile Ser 
65                  70                  75                  80  


His Ser Pro Asn Ser Thr Ala Gly Pro Ser Cys Thr Leu Leu Glu Glu 
                85                  90                  95      


Ala Phe Arg Arg Tyr His Gly Tyr Ile Phe Gly Phe Tyr Lys Trp His 
            100                 105                 110         


His Glu Pro Ala Glu Phe Gln Ala Lys Thr Gln Val Gln Gln Leu Leu 
        115                 120                 125             


Val Ser Ile Thr Leu Gln Ser Glu Cys Asp Ala Phe Pro Asn Ile Ser 
    130                 135                 140                 


Ser Asp Glu Ser Tyr Thr Leu Leu Val Lys Glu Pro Val Ala Val Leu 
145                 150                 155                 160 


Lys Ala Asn Arg Val Trp Gly Ala Leu Arg Gly Leu Glu Thr Phe Ser 
                165                 170                 175     


Gln Leu Val Tyr Gln Asp Ser Tyr Gly Thr Phe Thr Ile Asn Glu Ser 
            180                 185                 190         


Thr Ile Ile Asp Ser Pro Arg Phe Ser His Arg Gly Ile Leu Ile Asp 
        195                 200                 205             


Thr Ser Arg His Tyr Leu Pro Val Lys Ile Ile Leu Lys Thr Leu Asp 
    210                 215                 220                 


Ala Met Ala Phe Asn Lys Phe Asn Val Leu His Trp His Ile Val Asp 
225                 230                 235                 240 


Asp Gln Ser Phe Pro Tyr Gln Ser Ile Thr Phe Pro Glu Leu Ser Asn 
                245                 250                 255     


Lys Gly Ser Tyr Ser Leu Ser His Val Tyr Thr Pro Asn Asp Val Arg 
            260                 265                 270         


Met Val Ile Glu Tyr Ala Arg Leu Arg Gly Ile Arg Val Leu Pro Glu 
        275                 280                 285             


Phe Asp Thr Pro Gly His Thr Leu Ser Trp Gly Lys Gly Gln Lys Asp 
    290                 295                 300                 


Leu Leu Thr Pro Cys Tyr Ser Arg Gln Asn Lys Leu Asp Ser Phe Gly 
305                 310                 315                 320 


Pro Ile Asn Pro Thr Leu Asn Thr Thr Tyr Ser Phe Leu Thr Thr Phe 
                325                 330                 335     


Phe Lys Glu Ile Ser Glu Val Phe Pro Asp Gln Phe Ile His Leu Gly 
            340                 345                 350         


Gly Asp Glu Val Glu Phe Lys Cys Trp Glu Ser Asn Pro Lys Ile Gln 
        355                 360                 365             


Asp Phe Met Arg Gln Lys Gly Phe Gly Thr Asp Phe Lys Lys Leu Glu 
    370                 375                 380                 


Ser Phe Tyr Ile Gln Lys Val Leu Asp Ile Ile Ala Thr Ile Asn Lys 
385                 390                 395                 400 


Gly Ser Ile Val Trp Gln Glu Val Phe Asp Asp Lys Ala Lys Leu Ala 
                405                 410                 415     


Pro Gly Thr Ile Val Glu Val Trp Lys Asp Ser Ala Tyr Pro Glu Glu 
            420                 425                 430         


Leu Ser Arg Val Thr Ala Ser Gly Phe Pro Val Ile Leu Ser Ala Pro 
        435                 440                 445             


Trp Tyr Leu Asp Leu Ile Ser Tyr Gly Gln Asp Trp Arg Lys Tyr Tyr 
    450                 455                 460                 


Lys Val Glu Pro Leu Asp Phe Gly Gly Thr Gln Lys Gln Lys Gln Leu 
465                 470                 475                 480 


Phe Ile Gly Gly Glu Ala Cys Leu Trp Gly Glu Tyr Val Asp Ala Thr 
                485                 490                 495     


Asn Leu Thr Pro Arg Leu Trp Pro Arg Ala Ser Ala Val Gly Glu Arg 
            500                 505                 510         


Leu Trp Ser Ser Lys Asp Val Arg Asp Met Asp Asp Ala Tyr Asp Arg 
        515                 520                 525             


Leu Thr Arg His Arg Cys Arg Met Val Glu Arg Gly Ile Ala Ala Gln 
    530                 535                 540                 


Pro Leu Tyr Ala Gly Tyr Cys Asn His Glu Asn Met 
545                 550                 555     


