                               SEQUENCE LISTING

<110> UNIVERSITY OF MARYLAND, COLLEGE PARK
 
<120> AN Fc GLYCAN REMODELING PLATFORM METHOD FOR SITE-SPECIFIC 
      ANTIBODY CONJUGATION AND APPLICATIONS THEREOF

<130> 1475-79PCT

<140> PCT/US2022/026213
<141> 2022-04-25

<150> 63/264,012
<151> 2021-11-12

<150> 63/264,013
<151> 2021-11-12

<150> 63/178,719
<151> 2021-04-23

<160> 16    

<170> PatentIn version 3.5

<210> 1
<211> 815
<212> PRT
<213> Streptococcus pyogenes

<400> 1
Met Asp Lys His Leu Leu Val Lys Arg Thr Leu Gly Cys Val Cys Ala 
1               5                   10                  15      


Ala Thr Leu Met Gly Ala Ala Leu Ala Thr His His Asp Ser Leu Asn 
            20                  25                  30          


Thr Val Lys Ala Glu Glu Lys Thr Val Gln Thr Gly Lys Thr Asp Gln 
        35                  40                  45              


Gln Val Gly Ala Lys Leu Val Gln Glu Ile Arg Glu Gly Lys Arg Gly 
    50                  55                  60                  


Pro Leu Tyr Ala Gly Tyr Phe Arg Thr Trp His Asp Arg Ala Ser Thr 
65                  70                  75                  80  


Gly Ile Asp Gly Lys Gln Gln His Pro Glu Asn Thr Met Ala Glu Val 
                85                  90                  95      


Pro Lys Glu Val Asp Ile Leu Phe Val Phe His Asp His Thr Ala Ser 
            100                 105                 110         


Asp Ser Pro Phe Trp Ser Glu Leu Lys Asp Ser Tyr Val His Lys Leu 
        115                 120                 125             


His Gln Gln Gly Thr Ala Leu Val Gln Thr Ile Gly Val Asn Glu Leu 
    130                 135                 140                 


Asn Gly Arg Thr Gly Leu Ser Lys Asp Tyr Pro Asp Thr Pro Glu Gly 
145                 150                 155                 160 


Asn Lys Ala Leu Ala Ala Ala Ile Val Lys Ala Phe Val Thr Asp Arg 
                165                 170                 175     


Gly Val Asp Gly Leu Asp Ile Asp Ile Glu His Glu Phe Thr Asn Lys 
            180                 185                 190         


Arg Thr Pro Glu Glu Asp Ala Arg Ala Leu Asn Val Phe Lys Glu Ile 
        195                 200                 205             


Ala Gln Leu Ile Gly Lys Asn Gly Ser Asp Lys Ser Lys Leu Leu Ile 
    210                 215                 220                 


Met Asp Thr Thr Leu Ser Val Glu Asn Asn Pro Ile Phe Lys Gly Ile 
225                 230                 235                 240 


Ala Glu Asp Leu Asp Tyr Leu Leu Arg Gln Tyr Tyr Gly Ser Gln Gly 
                245                 250                 255     


Gly Glu Ala Glu Val Asp Thr Ile Asn Ser Asp Trp Asn Gln Tyr Gln 
            260                 265                 270         


Asn Tyr Ile Asp Ala Ser Gln Phe Met Ile Gly Phe Ser Phe Phe Glu 
        275                 280                 285             


Glu Ser Ala Ser Lys Gly Asn Leu Trp Phe Asp Val Asn Glu Tyr Asp 
    290                 295                 300                 


Pro Asn Asn Pro Glu Lys Gly Lys Asp Ile Glu Gly Thr Arg Ala Lys 
305                 310                 315                 320 


Lys Tyr Ala Glu Trp Gln Pro Ser Thr Gly Gly Leu Lys Ala Gly Ile 
                325                 330                 335     


Phe Ser Tyr Ala Ile Asp Arg Asp Gly Val Ala His Val Pro Ser Thr 
            340                 345                 350         


Tyr Lys Asn Arg Thr Ser Thr Asn Leu Gln Arg His Glu Val Asp Asn 
        355                 360                 365             


Ile Ser His Thr Asp Tyr Thr Val Ser Arg Lys Leu Lys Thr Leu Met 
    370                 375                 380                 


Thr Glu Asp Lys Arg Tyr Asp Val Ile Asp Gln Lys Asp Ile Pro Asp 
385                 390                 395                 400 


Pro Ala Leu Arg Glu Gln Ile Ile Gln Gln Val Gly Gln Tyr Lys Gly 
                405                 410                 415     


Asp Leu Glu Arg Tyr Asn Lys Thr Leu Val Leu Thr Gly Asp Lys Ile 
            420                 425                 430         


Gln Asn Leu Lys Gly Leu Glu Lys Leu Ser Lys Leu Gln Lys Leu Glu 
        435                 440                 445             


Leu Arg Gln Leu Ser Asn Val Lys Glu Ile Thr Pro Glu Leu Leu Pro 
    450                 455                 460                 


Glu Ser Met Lys Lys Asp Ala Glu Leu Val Met Val Gly Met Thr Gly 
465                 470                 475                 480 


Leu Glu Lys Leu Asn Leu Ser Gly Leu Asn Arg Gln Thr Leu Asp Gly 
                485                 490                 495     


Ile Asp Val Asn Ser Ile Thr His Leu Thr Ser Phe Asp Ile Ser His 
            500                 505                 510         


Asn Ser Leu Asp Leu Ser Glu Lys Ser Glu Asp Arg Lys Leu Leu Met 
        515                 520                 525             


Thr Leu Met Glu Gln Val Ser Asn His Gln Lys Ile Thr Val Lys Asn 
    530                 535                 540                 


Thr Ala Phe Glu Asn Gln Lys Pro Lys Gly Tyr Tyr Pro Gln Thr Tyr 
545                 550                 555                 560 


Asp Thr Lys Glu Gly His Tyr Asp Val Asp Asn Ala Glu His Asp Ile 
                565                 570                 575     


Leu Thr Asp Phe Val Phe Gly Thr Val Thr Lys Arg Asn Thr Phe Ile 
            580                 585                 590         


Gly Asp Glu Glu Ala Phe Ala Ile Tyr Lys Glu Gly Ala Val Asp Gly 
        595                 600                 605             


Arg Gln Tyr Val Ser Lys Asp Tyr Thr Tyr Glu Ala Phe Arg Lys Asp 
    610                 615                 620                 


Tyr Lys Gly Tyr Lys Val His Leu Thr Ala Ser Asn Leu Gly Glu Thr 
625                 630                 635                 640 


Val Thr Ser Lys Val Thr Ala Thr Thr Asp Glu Thr Tyr Leu Val Asp 
                645                 650                 655     


Val Ser Asp Gly Glu Lys Val Val His His Met Lys Leu Asn Ile Gly 
            660                 665                 670         


Ser Gly Ala Ile Met Met Glu Asn Leu Ala Lys Gly Ala Lys Val Ile 
        675                 680                 685             


Gly Thr Ser Gly Asp Phe Glu Gln Ala Lys Lys Ile Phe Asp Gly Glu 
    690                 695                 700                 


Lys Ser Asp Arg Phe Phe Thr Trp Gly Gln Thr Asn Trp Ile Ala Phe 
705                 710                 715                 720 


Asp Leu Gly Glu Ile Asn Leu Ala Lys Glu Trp Arg Leu Phe Asn Ala 
                725                 730                 735     


Glu Thr Asn Thr Glu Ile Lys Thr Asp Ser Ser Leu Asn Val Ala Lys 
            740                 745                 750         


Gly Arg Leu Gln Ile Leu Lys Asp Thr Thr Ile Asp Leu Glu Lys Met 
        755                 760                 765             


Asp Ile Lys Asn Arg Lys Glu Tyr Leu Ser Asn Asp Glu Asn Trp Thr 
    770                 775                 780                 


Asp Val Ala Gln Met Asp Asp Ala Lys Ala Ile Phe Asn Ser Lys Leu 
785                 790                 795                 800 


Ser Asn Val Leu Ser Arg Tyr Trp Arg Phe Cys Val Asp Gly Gly 
                805                 810                 815 


<210> 2
<211> 995
<212> PRT
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: 
      Synthetic polypeptide

<400> 2
Met Asp Lys His Leu Leu Val Lys Arg Thr Leu Gly Cys Val Cys Ala 
1               5                   10                  15      


Ala Thr Leu Met Gly Ala Ala Leu Ala Thr His His Asp Ser Leu Asn 
            20                  25                  30          


Thr Val Lys Ala Glu Glu Lys Thr Val Gln Val Gln Lys Gly Leu Pro 
        35                  40                  45              


Ser Ile Asp Ser Leu His Tyr Leu Ser Glu Asn Ser Lys Lys Glu Phe 
    50                  55                  60                  


Lys Glu Glu Leu Ser Lys Ala Gly Gln Glu Ser Gln Lys Val Lys Glu 
65                  70                  75                  80  


Ile Leu Ala Lys Ala Gln Gln Ala Asp Lys Gln Ala Gln Glu Leu Ala 
                85                  90                  95      


Lys Met Lys Ile Pro Glu Lys Ile Pro Met Lys Pro Leu His Gly Pro 
            100                 105                 110         


Leu Tyr Gly Gly Tyr Phe Arg Thr Trp His Asp Lys Thr Ser Asp Pro 
        115                 120                 125             


Thr Glu Lys Asp Lys Val Asn Ser Met Gly Glu Leu Pro Lys Glu Val 
    130                 135                 140                 


Asp Leu Ala Phe Ile Phe His Asp Trp Thr Lys Asp Tyr Ser Leu Phe 
145                 150                 155                 160 


Trp Lys Glu Leu Ala Thr Lys His Val Pro Lys Leu Asn Lys Gln Gly 
                165                 170                 175     


Thr Arg Val Ile Arg Thr Ile Pro Trp Arg Phe Leu Ala Gly Gly Asp 
            180                 185                 190         


Asn Ser Gly Ile Ala Glu Asp Thr Ser Lys Tyr Pro Asn Thr Pro Glu 
        195                 200                 205             


Gly Asn Lys Ala Leu Ala Lys Ala Ile Val Asp Glu Tyr Val Tyr Lys 
    210                 215                 220                 


Tyr Asn Leu Asp Gly Leu Asp Val Gln Val Glu His Asp Ser Ile Pro 
225                 230                 235                 240 


Lys Val Asp Lys Lys Glu Asp Thr Ala Gly Val Glu Arg Ser Ile Gln 
                245                 250                 255     


Val Phe Glu Glu Ile Gly Lys Leu Ile Gly Pro Lys Gly Val Asp Lys 
            260                 265                 270         


Ser Arg Leu Phe Ile Met Asp Ser Thr Tyr Met Ala Asp Lys Asn Pro 
        275                 280                 285             


Leu Ile Glu Arg Gly Ala Pro Tyr Ile Asn Leu Leu Leu Val Gln Val 
    290                 295                 300                 


Tyr Gly Ser Gln Gly Glu Lys Gly Gly Trp Glu Pro Val Ser Asn Arg 
305                 310                 315                 320 


Pro Glu Lys Thr Met Glu Glu Arg Trp Gln Gly Tyr Ser Lys Tyr Ile 
                325                 330                 335     


Arg Pro Glu Gln Tyr Met Ile Gly Phe Ser Phe Tyr Glu Glu Asn Ala 
            340                 345                 350         


Gln Glu Gly Asn Leu Trp Tyr Asp Ile Asn Ser Arg Lys Asp Glu Asp 
        355                 360                 365             


Lys Ala Asn Gly Ile Asn Thr Asp Ile Thr Gly Thr Arg Ala Glu Arg 
    370                 375                 380                 


Tyr Ala Arg Trp Gln Pro Lys Thr Gly Gly Val Lys Gly Gly Ile Phe 
385                 390                 395                 400 


Ser Tyr Ala Ile Asp Arg Asp Gly Val Ala His Gln Pro Lys Lys Tyr 
                405                 410                 415     


Ala Lys Gln Lys Glu Phe Lys Asp Ala Thr Asp Asn Ile Phe His Ser 
            420                 425                 430         


Asp Tyr Ser Val Ser Lys Ala Leu Lys Thr Val Met Leu Lys Asp Lys 
        435                 440                 445             


Ser Tyr Asp Leu Ile Asp Glu Lys Asp Phe Pro Asp Lys Ala Leu Arg 
    450                 455                 460                 


Glu Ala Val Met Ala Gln Val Gly Thr Arg Lys Gly Asp Leu Glu Arg 
465                 470                 475                 480 


Phe Asn Gly Thr Leu Arg Leu Asp Asn Pro Ala Ile Gln Ser Leu Glu 
                485                 490                 495     


Gly Leu Asn Lys Phe Lys Lys Leu Ala Gln Leu Asp Leu Ile Gly Leu 
            500                 505                 510         


Ser Arg Ile Thr Lys Leu Asp Arg Ser Val Leu Pro Ala Asn Met Lys 
        515                 520                 525             


Pro Gly Lys Asp Thr Leu Glu Thr Val Leu Glu Thr Tyr Lys Lys Asp 
    530                 535                 540                 


Asn Lys Glu Glu Pro Ala Thr Ile Pro Pro Val Ser Leu Lys Val Ser 
545                 550                 555                 560 


Gly Leu Thr Gly Leu Lys Glu Leu Asp Leu Ser Gly Phe Asp Arg Glu 
                565                 570                 575     


Thr Leu Ala Gly Leu Asp Ala Ala Thr Leu Thr Ser Leu Glu Lys Val 
            580                 585                 590         


Asp Ile Ser Gly Asn Lys Leu Asp Leu Ala Pro Gly Thr Glu Asn Arg 
        595                 600                 605             


Gln Ile Phe Asp Thr Met Leu Ser Thr Ile Ser Asn His Val Gly Ser 
    610                 615                 620                 


Asn Glu Gln Thr Val Lys Phe Asp Lys Gln Lys Pro Thr Gly His Tyr 
625                 630                 635                 640 


Pro Asp Thr Tyr Gly Lys Thr Ser Leu Arg Leu Pro Val Ala Asn Glu 
                645                 650                 655     


Lys Val Asp Leu Gln Ser Gln Leu Leu Phe Gly Thr Val Thr Asn Gln 
            660                 665                 670         


Gly Thr Leu Ile Asn Ser Glu Ala Asp Tyr Lys Ala Tyr Gln Asn His 
        675                 680                 685             


Lys Ile Ala Gly Arg Ser Phe Val Asp Ser Asn Tyr His Tyr Asn Asn 
    690                 695                 700                 


Phe Lys Val Ser Tyr Glu Asn Tyr Thr Val Lys Val Thr Asp Ser Thr 
705                 710                 715                 720 


Leu Gly Thr Thr Thr Asp Lys Thr Leu Ala Thr Asp Lys Glu Glu Thr 
                725                 730                 735     


Tyr Lys Val Asp Phe Phe Ser Pro Ala Asp Lys Thr Lys Ala Val His 
            740                 745                 750         


Thr Ala Lys Val Ile Val Gly Asp Glu Lys Thr Met Met Val Asn Leu 
        755                 760                 765             


Ala Glu Gly Ala Thr Val Ile Gly Gly Ser Ala Asp Pro Val Asn Ala 
    770                 775                 780                 


Arg Lys Val Phe Asp Gly Gln Leu Gly Ser Glu Thr Asp Asn Ile Ser 
785                 790                 795                 800 


Leu Gly Trp Asp Ser Lys Gln Ser Ile Ile Phe Lys Leu Lys Glu Asp 
                805                 810                 815     


Gly Leu Ile Lys His Trp Arg Phe Phe Asn Asp Ser Ala Arg Asn Pro 
            820                 825                 830         


Glu Thr Thr Asn Lys Pro Ile Gln Glu Ala Ser Leu Gln Ile Phe Asn 
        835                 840                 845             


Ile Lys Asp Tyr Asn Leu Asp Asn Leu Leu Glu Asn Pro Asn Lys Phe 
    850                 855                 860                 


Asp Asp Glu Lys Tyr Trp Ile Thr Val Asp Thr Tyr Ser Ala Gln Gly 
865                 870                 875                 880 


Glu Arg Ala Thr Ala Phe Ser Asn Thr Leu Asn Asn Ile Thr Ser Lys 
                885                 890                 895     


Tyr Trp Arg Val Val Phe Asp Thr Lys Gly Asp Arg Tyr Ser Ser Pro 
            900                 905                 910         


Val Val Pro Glu Leu Gln Ile Leu Gly Tyr Pro Leu Pro Asn Ala Asp 
        915                 920                 925             


Thr Ile Met Lys Thr Val Thr Thr Ala Lys Glu Leu Ser Gln Gln Lys 
    930                 935                 940                 


Asp Lys Phe Ser Gln Lys Met Leu Asp Glu Leu Lys Ile Lys Glu Met 
945                 950                 955                 960 


Ala Leu Glu Thr Ser Leu Asn Ser Lys Ile Phe Asp Val Thr Ala Ile 
                965                 970                 975     


Asn Ala Asn Ala Gly Val Leu Lys Asp Cys Ile Glu Lys Arg Gln Leu 
            980                 985                 990         


Leu Lys Lys 
        995 


<210> 3
<211> 995
<212> PRT
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: 
      Synthetic polypeptide

<400> 3
Met Asp Lys His Leu Leu Val Lys Arg Thr Leu Gly Cys Val Cys Ala 
1               5                   10                  15      


Ala Thr Leu Met Gly Ala Ala Leu Ala Thr His His Asp Ser Leu Asn 
            20                  25                  30          


Thr Val Lys Ala Glu Glu Lys Thr Val Gln Val Gln Lys Gly Leu Pro 
        35                  40                  45              


Ser Ile Asp Ser Leu His Tyr Leu Ser Glu Asn Ser Lys Lys Glu Phe 
    50                  55                  60                  


Lys Glu Glu Leu Ser Lys Ala Gly Gln Glu Ser Gln Lys Val Lys Glu 
65                  70                  75                  80  


Ile Leu Ala Lys Ala Gln Gln Ala Asp Lys Gln Ala Gln Glu Leu Ala 
                85                  90                  95      


Lys Met Lys Ile Pro Glu Lys Ile Pro Met Lys Pro Leu His Gly Pro 
            100                 105                 110         


Leu Tyr Gly Gly Tyr Phe Arg Thr Trp His Asp Lys Thr Ser Asp Pro 
        115                 120                 125             


Thr Glu Lys Asp Lys Val Asn Ser Met Gly Glu Leu Pro Lys Glu Val 
    130                 135                 140                 


Asp Leu Ala Phe Ile Phe His Asp Trp Thr Lys Asp Tyr Ser Leu Phe 
145                 150                 155                 160 


Trp Lys Glu Leu Ala Thr Lys His Val Pro Lys Leu Asn Lys Gln Gly 
                165                 170                 175     


Thr Arg Val Ile Arg Thr Ile Pro Trp Arg Phe Leu Ala Gly Gly Asp 
            180                 185                 190         


Asn Ser Gly Ile Ala Glu Asp Thr Ser Lys Tyr Pro Asn Thr Pro Glu 
        195                 200                 205             


Gly Asn Lys Ala Leu Ala Lys Ala Ile Val Asp Glu Tyr Val Tyr Lys 
    210                 215                 220                 


Tyr Asn Leu Asp Gly Leu Asp Val Ala Val Glu His Asp Ser Ile Pro 
225                 230                 235                 240 


Lys Val Asp Lys Lys Glu Asp Thr Ala Gly Val Glu Arg Ser Ile Gln 
                245                 250                 255     


Val Phe Glu Glu Ile Gly Lys Leu Ile Gly Pro Lys Gly Val Asp Lys 
            260                 265                 270         


Ser Arg Leu Phe Ile Met Asp Ser Thr Tyr Met Ala Asp Lys Asn Pro 
        275                 280                 285             


Leu Ile Glu Arg Gly Ala Pro Tyr Ile Asn Leu Leu Leu Val Gln Val 
    290                 295                 300                 


Tyr Gly Ser Gln Gly Glu Lys Gly Gly Trp Glu Pro Val Ser Asn Arg 
305                 310                 315                 320 


Pro Glu Lys Thr Met Glu Glu Arg Trp Gln Gly Tyr Ser Lys Tyr Ile 
                325                 330                 335     


Arg Pro Glu Gln Tyr Met Ile Gly Phe Ser Phe Tyr Glu Glu Asn Ala 
            340                 345                 350         


Gln Glu Gly Asn Leu Trp Tyr Asp Ile Asn Ser Arg Lys Asp Glu Asp 
        355                 360                 365             


Lys Ala Asn Gly Ile Asn Thr Asp Ile Thr Gly Thr Arg Ala Glu Arg 
    370                 375                 380                 


Tyr Ala Arg Trp Gln Pro Lys Thr Gly Gly Val Lys Gly Gly Ile Phe 
385                 390                 395                 400 


Ser Tyr Ala Ile Asp Arg Asp Gly Val Ala His Gln Pro Lys Lys Tyr 
                405                 410                 415     


Ala Lys Gln Lys Glu Phe Lys Asp Ala Thr Asp Asn Ile Phe His Ser 
            420                 425                 430         


Asp Tyr Ser Val Ser Lys Ala Leu Lys Thr Val Met Leu Lys Asp Lys 
        435                 440                 445             


Ser Tyr Asp Leu Ile Asp Glu Lys Asp Phe Pro Asp Lys Ala Leu Arg 
    450                 455                 460                 


Glu Ala Val Met Ala Gln Val Gly Thr Arg Lys Gly Asp Leu Glu Arg 
465                 470                 475                 480 


Phe Asn Gly Thr Leu Arg Leu Asp Asn Pro Ala Ile Gln Ser Leu Glu 
                485                 490                 495     


Gly Leu Asn Lys Phe Lys Lys Leu Ala Gln Leu Asp Leu Ile Gly Leu 
            500                 505                 510         


Ser Arg Ile Thr Lys Leu Asp Arg Ser Val Leu Pro Ala Asn Met Lys 
        515                 520                 525             


Pro Gly Lys Asp Thr Leu Glu Thr Val Leu Glu Thr Tyr Lys Lys Asp 
    530                 535                 540                 


Asn Lys Glu Glu Pro Ala Thr Ile Pro Pro Val Ser Leu Lys Val Ser 
545                 550                 555                 560 


Gly Leu Thr Gly Leu Lys Glu Leu Asp Leu Ser Gly Phe Asp Arg Glu 
                565                 570                 575     


Thr Leu Ala Gly Leu Asp Ala Ala Thr Leu Thr Ser Leu Glu Lys Val 
            580                 585                 590         


Asp Ile Ser Gly Asn Lys Leu Asp Leu Ala Pro Gly Thr Glu Asn Arg 
        595                 600                 605             


Gln Ile Phe Asp Thr Met Leu Ser Thr Ile Ser Asn His Val Gly Ser 
    610                 615                 620                 


Asn Glu Gln Thr Val Lys Phe Asp Lys Gln Lys Pro Thr Gly His Tyr 
625                 630                 635                 640 


Pro Asp Thr Tyr Gly Lys Thr Ser Leu Arg Leu Pro Val Ala Asn Glu 
                645                 650                 655     


Lys Val Asp Leu Gln Ser Gln Leu Leu Phe Gly Thr Val Thr Asn Gln 
            660                 665                 670         


Gly Thr Leu Ile Asn Ser Glu Ala Asp Tyr Lys Ala Tyr Gln Asn His 
        675                 680                 685             


Lys Ile Ala Gly Arg Ser Phe Val Asp Ser Asn Tyr His Tyr Asn Asn 
    690                 695                 700                 


Phe Lys Val Ser Tyr Glu Asn Tyr Thr Val Lys Val Thr Asp Ser Thr 
705                 710                 715                 720 


Leu Gly Thr Thr Thr Asp Lys Thr Leu Ala Thr Asp Lys Glu Glu Thr 
                725                 730                 735     


Tyr Lys Val Asp Phe Phe Ser Pro Ala Asp Lys Thr Lys Ala Val His 
            740                 745                 750         


Thr Ala Lys Val Ile Val Gly Asp Glu Lys Thr Met Met Val Asn Leu 
        755                 760                 765             


Ala Glu Gly Ala Thr Val Ile Gly Gly Ser Ala Asp Pro Val Asn Ala 
    770                 775                 780                 


Arg Lys Val Phe Asp Gly Gln Leu Gly Ser Glu Thr Asp Asn Ile Ser 
785                 790                 795                 800 


Leu Gly Trp Asp Ser Lys Gln Ser Ile Ile Phe Lys Leu Lys Glu Asp 
                805                 810                 815     


Gly Leu Ile Lys His Trp Arg Phe Phe Asn Asp Ser Ala Arg Asn Pro 
            820                 825                 830         


Glu Thr Thr Asn Lys Pro Ile Gln Glu Ala Ser Leu Gln Ile Phe Asn 
        835                 840                 845             


Ile Lys Asp Tyr Asn Leu Asp Asn Leu Leu Glu Asn Pro Asn Lys Phe 
    850                 855                 860                 


Asp Asp Glu Lys Tyr Trp Ile Thr Val Asp Thr Tyr Ser Ala Gln Gly 
865                 870                 875                 880 


Glu Arg Ala Thr Ala Phe Ser Asn Thr Leu Asn Asn Ile Thr Ser Lys 
                885                 890                 895     


Tyr Trp Arg Val Val Phe Asp Thr Lys Gly Asp Arg Tyr Ser Ser Pro 
            900                 905                 910         


Val Val Pro Glu Leu Gln Ile Leu Gly Tyr Pro Leu Pro Asn Ala Asp 
        915                 920                 925             


Thr Ile Met Lys Thr Val Thr Thr Ala Lys Glu Leu Ser Gln Gln Lys 
    930                 935                 940                 


Asp Lys Phe Ser Gln Lys Met Leu Asp Glu Leu Lys Ile Lys Glu Met 
945                 950                 955                 960 


Ala Leu Glu Thr Ser Leu Asn Ser Lys Ile Phe Asp Val Thr Ala Ile 
                965                 970                 975     


Asn Ala Asn Ala Gly Val Leu Lys Asp Cys Ile Glu Lys Arg Gln Leu 
            980                 985                 990         


Leu Lys Lys 
        995 


<210> 4
<211> 995
<212> PRT
<213> Streptococcus pyogenes

<400> 4
Met Asp Lys His Leu Leu Val Lys Arg Thr Leu Gly Cys Val Cys Ala 
1               5                   10                  15      


Ala Thr Leu Met Gly Ala Ala Leu Ala Thr His His Asp Ser Leu Asn 
            20                  25                  30          


Thr Val Lys Ala Glu Glu Lys Thr Val Gln Val Gln Lys Gly Leu Pro 
        35                  40                  45              


Ser Ile Asp Ser Leu His Tyr Leu Ser Glu Asn Ser Lys Lys Glu Phe 
    50                  55                  60                  


Lys Glu Glu Leu Ser Lys Ala Gly Gln Glu Ser Gln Lys Val Lys Glu 
65                  70                  75                  80  


Ile Leu Ala Lys Ala Gln Gln Ala Asp Lys Gln Ala Gln Glu Leu Ala 
                85                  90                  95      


Lys Met Lys Ile Pro Glu Lys Ile Pro Met Lys Pro Leu His Gly Pro 
            100                 105                 110         


Leu Tyr Gly Gly Tyr Phe Arg Thr Trp His Asp Lys Thr Ser Asp Pro 
        115                 120                 125             


Thr Glu Lys Asp Lys Val Asn Ser Met Gly Glu Leu Pro Lys Glu Val 
    130                 135                 140                 


Asp Leu Ala Phe Ile Phe His Asp Trp Thr Lys Asp Tyr Ser Leu Phe 
145                 150                 155                 160 


Trp Lys Glu Leu Ala Thr Lys His Val Pro Lys Leu Asn Lys Gln Gly 
                165                 170                 175     


Thr Arg Val Ile Arg Thr Ile Pro Trp Arg Phe Leu Ala Gly Gly Asp 
            180                 185                 190         


Asn Ser Gly Ile Ala Glu Asp Thr Ser Lys Tyr Pro Asn Thr Pro Glu 
        195                 200                 205             


Gly Asn Lys Ala Leu Ala Lys Ala Ile Val Asp Glu Tyr Val Tyr Lys 
    210                 215                 220                 


Tyr Asn Leu Asp Gly Leu Asp Val Asp Val Glu His Asp Ser Ile Pro 
225                 230                 235                 240 


Lys Val Asp Lys Lys Glu Asp Thr Ala Gly Val Glu Arg Ser Ile Gln 
                245                 250                 255     


Val Phe Glu Glu Ile Gly Lys Leu Ile Gly Pro Lys Gly Val Asp Lys 
            260                 265                 270         


Ser Arg Leu Phe Ile Met Asp Ser Thr Tyr Met Ala Asp Lys Asn Pro 
        275                 280                 285             


Leu Ile Glu Arg Gly Ala Pro Tyr Ile Asn Leu Leu Leu Val Gln Val 
    290                 295                 300                 


Tyr Gly Ser Gln Gly Glu Lys Gly Gly Trp Glu Pro Val Ser Asn Arg 
305                 310                 315                 320 


Pro Glu Lys Thr Met Glu Glu Arg Trp Gln Gly Tyr Ser Lys Tyr Ile 
                325                 330                 335     


Arg Pro Glu Gln Tyr Met Ile Gly Phe Ser Phe Tyr Glu Glu Asn Ala 
            340                 345                 350         


Gln Glu Gly Asn Leu Trp Tyr Asp Ile Asn Ser Arg Lys Asp Glu Asp 
        355                 360                 365             


Lys Ala Asn Gly Ile Asn Thr Asp Ile Thr Gly Thr Arg Ala Glu Arg 
    370                 375                 380                 


Tyr Ala Arg Trp Gln Pro Lys Thr Gly Gly Val Lys Gly Gly Ile Phe 
385                 390                 395                 400 


Ser Tyr Ala Ile Asp Arg Asp Gly Val Ala His Gln Pro Lys Lys Tyr 
                405                 410                 415     


Ala Lys Gln Lys Glu Phe Lys Asp Ala Thr Asp Asn Ile Phe His Ser 
            420                 425                 430         


Asp Tyr Ser Val Ser Lys Ala Leu Lys Thr Val Met Leu Lys Asp Lys 
        435                 440                 445             


Ser Tyr Asp Leu Ile Asp Glu Lys Asp Phe Pro Asp Lys Ala Leu Arg 
    450                 455                 460                 


Glu Ala Val Met Ala Gln Val Gly Thr Arg Lys Gly Asp Leu Glu Arg 
465                 470                 475                 480 


Phe Asn Gly Thr Leu Arg Leu Asp Asn Pro Ala Ile Gln Ser Leu Glu 
                485                 490                 495     


Gly Leu Asn Lys Phe Lys Lys Leu Ala Gln Leu Asp Leu Ile Gly Leu 
            500                 505                 510         


Ser Arg Ile Thr Lys Leu Asp Arg Ser Val Leu Pro Ala Asn Met Lys 
        515                 520                 525             


Pro Gly Lys Asp Thr Leu Glu Thr Val Leu Glu Thr Tyr Lys Lys Asp 
    530                 535                 540                 


Asn Lys Glu Glu Pro Ala Thr Ile Pro Pro Val Ser Leu Lys Val Ser 
545                 550                 555                 560 


Gly Leu Thr Gly Leu Lys Glu Leu Asp Leu Ser Gly Phe Asp Arg Glu 
                565                 570                 575     


Thr Leu Ala Gly Leu Asp Ala Ala Thr Leu Thr Ser Leu Glu Lys Val 
            580                 585                 590         


Asp Ile Ser Gly Asn Lys Leu Asp Leu Ala Pro Gly Thr Glu Asn Arg 
        595                 600                 605             


Gln Ile Phe Asp Thr Met Leu Ser Thr Ile Ser Asn His Val Gly Ser 
    610                 615                 620                 


Asn Glu Gln Thr Val Lys Phe Asp Lys Gln Lys Pro Thr Gly His Tyr 
625                 630                 635                 640 


Pro Asp Thr Tyr Gly Lys Thr Ser Leu Arg Leu Pro Val Ala Asn Glu 
                645                 650                 655     


Lys Val Asp Leu Gln Ser Gln Leu Leu Phe Gly Thr Val Thr Asn Gln 
            660                 665                 670         


Gly Thr Leu Ile Asn Ser Glu Ala Asp Tyr Lys Ala Tyr Gln Asn His 
        675                 680                 685             


Lys Ile Ala Gly Arg Ser Phe Val Asp Ser Asn Tyr His Tyr Asn Asn 
    690                 695                 700                 


Phe Lys Val Ser Tyr Glu Asn Tyr Thr Val Lys Val Thr Asp Ser Thr 
705                 710                 715                 720 


Leu Gly Thr Thr Thr Asp Lys Thr Leu Ala Thr Asp Lys Glu Glu Thr 
                725                 730                 735     


Tyr Lys Val Asp Phe Phe Ser Pro Ala Asp Lys Thr Lys Ala Val His 
            740                 745                 750         


Thr Ala Lys Val Ile Val Gly Asp Glu Lys Thr Met Met Val Asn Leu 
        755                 760                 765             


Ala Glu Gly Ala Thr Val Ile Gly Gly Ser Ala Asp Pro Val Asn Ala 
    770                 775                 780                 


Arg Lys Val Phe Asp Gly Gln Leu Gly Ser Glu Thr Asp Asn Ile Ser 
785                 790                 795                 800 


Leu Gly Trp Asp Ser Lys Gln Ser Ile Ile Phe Lys Leu Lys Glu Asp 
                805                 810                 815     


Gly Leu Ile Lys His Trp Arg Phe Phe Asn Asp Ser Ala Arg Asn Pro 
            820                 825                 830         


Glu Thr Thr Asn Lys Pro Ile Gln Glu Ala Ser Leu Gln Ile Phe Asn 
        835                 840                 845             


Ile Lys Asp Tyr Asn Leu Asp Asn Leu Leu Glu Asn Pro Asn Lys Phe 
    850                 855                 860                 


Asp Asp Glu Lys Tyr Trp Ile Thr Val Asp Thr Tyr Ser Ala Gln Gly 
865                 870                 875                 880 


Glu Arg Ala Thr Ala Phe Ser Asn Thr Leu Asn Asn Ile Thr Ser Lys 
                885                 890                 895     


Tyr Trp Arg Val Val Phe Asp Thr Lys Gly Asp Arg Tyr Ser Ser Pro 
            900                 905                 910         


Val Val Pro Glu Leu Gln Ile Leu Gly Tyr Pro Leu Pro Asn Ala Asp 
        915                 920                 925             


Thr Ile Met Lys Thr Val Thr Thr Ala Lys Glu Leu Ser Gln Gln Lys 
    930                 935                 940                 


Asp Lys Phe Ser Gln Lys Met Leu Asp Glu Leu Lys Ile Lys Glu Met 
945                 950                 955                 960 


Ala Leu Glu Thr Ser Leu Asn Ser Lys Ile Phe Asp Val Thr Ala Ile 
                965                 970                 975     


Asn Ala Asn Ala Gly Val Leu Lys Asp Cys Ile Glu Lys Arg Gln Leu 
            980                 985                 990         


Leu Lys Lys 
        995 


<210> 5
<211> 329
<212> PRT
<213> Elizabethkingia meningoseptica

<400> 5
Met Lys Lys Ile Phe Phe Ala Gln Cys Ser Ile Leu Leu Leu Met Leu 
1               5                   10                  15      


Gly Ser Cys Ser Lys Met Thr Glu Asp Met Thr Pro Glu Ser Val Asn 
            20                  25                  30          


Lys Glu Ala Ser Val Lys Ser Ala Thr Ala Leu Ala Gly Ser Asn Gly 
        35                  40                  45              


Val Cys Ile Ala Tyr Tyr Ile Thr Asp Gly Arg Asn Pro Thr Phe Lys 
    50                  55                  60                  


Leu Lys Asp Ile Pro Asp Lys Val Asp Met Val Ile Leu Phe Gly Leu 
65                  70                  75                  80  


Lys Tyr Trp Ser Leu Gln Asp Thr Thr Lys Leu Pro Gly Gly Thr Gly 
                85                  90                  95      


Met Met Gly Ser Phe Lys Ser Tyr Lys Asp Leu Asp Thr Gln Ile Arg 
            100                 105                 110         


Ser Leu Gln Ser Arg Gly Ile Lys Val Leu Gln Asn Ile Asp Asp Asp 
        115                 120                 125             


Val Ser Trp Gln Ser Ser Lys Pro Gly Gly Phe Ala Ser Ala Ala Ala 
    130                 135                 140                 


Tyr Gly Asp Ala Ile Lys Ser Ile Val Ile Asp Lys Trp Lys Leu Asp 
145                 150                 155                 160 


Gly Ile Ser Leu Asp Ile Glu His Ser Gly Ala Lys Pro Asn Pro Ile 
                165                 170                 175     


Pro Thr Phe Pro Gly Tyr Ala Ala Thr Gly Tyr Asn Gly Trp Tyr Ser 
            180                 185                 190         


Gly Ser Met Ala Ala Thr Pro Ala Phe Leu Asn Val Ile Ser Glu Leu 
        195                 200                 205             


Thr Lys Tyr Phe Gly Thr Thr Ala Pro Asn Asn Lys Gln Leu Gln Ile 
    210                 215                 220                 


Ala Ser Gly Ile Asp Val Tyr Ala Trp Asn Lys Ile Met Glu Asn Phe 
225                 230                 235                 240 


Arg Asn Asn Phe Asn Tyr Ile Gln Leu Gln Ser Tyr Gly Ala Asn Val 
                245                 250                 255     


Ser Arg Thr Gln Leu Met Met Asn Tyr Ala Thr Gly Thr Asn Lys Ile 
            260                 265                 270         


Pro Ala Ser Lys Met Val Phe Gly Ala Tyr Ala Glu Gly Gly Thr Asn 
        275                 280                 285             


Gln Ala Asn Asp Val Glu Val Ala Lys Trp Thr Pro Thr Gln Gly Ala 
    290                 295                 300                 


Lys Gly Gly Met Met Ile Tyr Thr Tyr Asn Ser Asn Val Ser Tyr Ala 
305                 310                 315                 320 


Asn Ala Val Arg Asp Ala Val Lys Asn 
                325                 


<210> 6
<211> 819
<212> PRT
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: 
      Synthetic polypeptide

<400> 6
Met Asp Lys His Leu Leu Val Lys Arg Thr Leu Gly Cys Val Cys Ala 
1               5                   10                  15      


Ala Thr Leu Met Gly Ala Ala Leu Ala Thr His His Asp Ser Leu Asn 
            20                  25                  30          


Thr Val Lys Ala Glu Glu Lys Thr Val Gln Thr Gly Lys Thr Asp Gln 
        35                  40                  45              


Gln Val Gly Ala Lys Leu Val Gln Glu Ile Arg Glu Gly Lys Arg Gly 
    50                  55                  60                  


Pro Leu Tyr Ala Gly Tyr Phe Arg Thr Trp His Asp Arg Ala Ser Thr 
65                  70                  75                  80  


Gly Ile Asp Gly Lys Gln Gln His Pro Glu Asn Thr Met Ala Glu Val 
                85                  90                  95      


Pro Lys Glu Val Asp Ile Leu Phe Val Phe His Asp His Thr Ala Ser 
            100                 105                 110         


Asp Ser Pro Phe Trp Ser Glu Leu Lys Asp Ser Tyr Val His Lys Leu 
        115                 120                 125             


His Gln Gln Gly Thr Ala Leu Val Gln Thr Ile Gly Val Asn Glu Leu 
    130                 135                 140                 


Asn Gly Arg Thr Gly Leu Ser Lys Asp Tyr Pro Asp Thr Pro Glu Gly 
145                 150                 155                 160 


Asn Lys Ala Leu Ala Ala Ala Ile Val Lys Ala Phe Val Thr Asp Arg 
                165                 170                 175     


Gly Val Asp Gly Leu Asp Ile Ala Ile Glu His Glu Phe Thr Asn Lys 
            180                 185                 190         


Arg Thr Pro Glu Glu Asp Ala Arg Ala Leu Asn Val Phe Lys Glu Ile 
        195                 200                 205             


Ala Gln Leu Ile Gly Lys Asn Gly Ser Asp Lys Ser Lys Leu Leu Ile 
    210                 215                 220                 


Met Asp Thr Thr Leu Ser Val Glu Asn Asn Pro Ile Phe Lys Gly Ile 
225                 230                 235                 240 


Ala Glu Asp Leu Asp Tyr Leu Leu Arg Gln Tyr Tyr Gly Ser Gln Gly 
                245                 250                 255     


Gly Glu Ala Glu Val Asp Thr Ile Asn Ser Asp Trp Asn Gln Tyr Gln 
            260                 265                 270         


Asn Tyr Ile Asp Ala Ser Gln Phe Met Ile Gly Phe Ser Phe Phe Glu 
        275                 280                 285             


Glu Ser Ala Ser Lys Gly Asn Leu Trp Phe Asp Val Asn Glu Tyr Asp 
    290                 295                 300                 


Pro Asn Asn Pro Glu Lys Gly Lys Asp Ile Glu Gly Thr Arg Ala Lys 
305                 310                 315                 320 


Lys Tyr Ala Glu Trp Gln Pro Ser Thr Gly Gly Leu Lys Ala Gly Ile 
                325                 330                 335     


Phe Ser Tyr Ala Ile Asp Arg Asp Gly Val Ala His Val Pro Ser Thr 
            340                 345                 350         


Tyr Lys Asn Arg Thr Ser Thr Asn Leu Gln Arg His Glu Val Asp Asn 
        355                 360                 365             


Ile Ser His Thr Asp Tyr Thr Val Ser Arg Lys Leu Lys Thr Leu Met 
    370                 375                 380                 


Thr Glu Asp Lys Arg Tyr Asp Val Ile Asp Gln Lys Asp Ile Pro Asp 
385                 390                 395                 400 


Pro Ala Leu Arg Glu Gln Ile Ile Gln Gln Val Gly Gln Tyr Lys Gly 
                405                 410                 415     


Asp Leu Glu Arg Tyr Asn Lys Thr Leu Val Leu Thr Gly Asp Lys Ile 
            420                 425                 430         


Gln Asn Leu Lys Gly Leu Glu Lys Leu Ser Lys Leu Gln Lys Leu Glu 
        435                 440                 445             


Leu Arg Gln Leu Ser Asn Val Lys Glu Ile Thr Pro Glu Leu Leu Pro 
    450                 455                 460                 


Glu Ser Met Lys Lys Asp Ala Glu Leu Val Met Val Gly Met Thr Gly 
465                 470                 475                 480 


Leu Glu Lys Leu Asn Leu Ser Gly Leu Asn Arg Gln Thr Leu Asp Gly 
                485                 490                 495     


Ile Asp Val Asn Ser Ile Thr His Leu Thr Ser Phe Asp Ile Ser His 
            500                 505                 510         


Asn Ser Leu Asp Leu Ser Glu Lys Ser Glu Asp Arg Lys Leu Leu Met 
        515                 520                 525             


Thr Leu Met Glu Gln Val Ser Asn His Gln Lys Ile Thr Val Lys Asn 
    530                 535                 540                 


Thr Ala Phe Glu Asn Gln Lys Pro Lys Gly Tyr Tyr Pro Gln Thr Tyr 
545                 550                 555                 560 


Asp Thr Lys Glu Gly His Tyr Asp Val Asp Asn Ala Glu His Asp Ile 
                565                 570                 575     


Leu Thr Asp Phe Val Phe Gly Thr Val Thr Lys Arg Asn Thr Phe Ile 
            580                 585                 590         


Gly Asp Glu Glu Ala Phe Ala Ile Tyr Lys Glu Gly Ala Val Asp Gly 
        595                 600                 605             


Arg Gln Tyr Val Ser Lys Asp Tyr Thr Tyr Glu Ala Phe Arg Lys Asp 
    610                 615                 620                 


Tyr Lys Gly Tyr Lys Val His Leu Thr Ala Ser Asn Leu Gly Glu Thr 
625                 630                 635                 640 


Val Thr Ser Lys Val Thr Ala Thr Thr Asp Glu Thr Tyr Leu Val Asp 
                645                 650                 655     


Val Ser Asp Gly Glu Lys Val Val His His Met Lys Leu Asn Ile Gly 
            660                 665                 670         


Ser Gly Ala Ile Met Met Glu Asn Leu Ala Lys Gly Ala Lys Val Ile 
        675                 680                 685             


Gly Thr Ser Gly Asp Phe Glu Gln Ala Lys Lys Ile Phe Asp Gly Glu 
    690                 695                 700                 


Lys Ser Asp Arg Phe Phe Thr Trp Gly Gln Thr Asn Trp Ile Ala Phe 
705                 710                 715                 720 


Asp Leu Gly Glu Ile Asn Leu Ala Lys Glu Trp Arg Leu Phe Asn Ala 
                725                 730                 735     


Glu Thr Asn Thr Glu Ile Lys Thr Asp Ser Ser Leu Asn Val Ala Lys 
            740                 745                 750         


Gly Arg Leu Gln Ile Leu Lys Asp Thr Thr Ile Asp Leu Glu Lys Met 
        755                 760                 765             


Asp Ile Lys Asn Arg Lys Glu Tyr Leu Ser Asn Asp Glu Asn Trp Thr 
    770                 775                 780                 


Asp Val Ala Gln Met Asp Asp Ala Lys Ala Ile Phe Asn Ser Lys Leu 
785                 790                 795                 800 


Ser Asn Val Leu Ser Arg Tyr Trp Arg Phe Cys Val Asp Gly Gly Ala 
                805                 810                 815     


Ser Ser Tyr 
            


<210> 7
<211> 819
<212> PRT
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: 
      Synthetic polypeptide

<400> 7
Met Asp Lys His Leu Leu Val Lys Arg Thr Leu Gly Cys Val Cys Ala 
1               5                   10                  15      


Ala Thr Leu Met Gly Ala Ala Leu Ala Thr His His Asp Ser Leu Asn 
            20                  25                  30          


Thr Val Lys Ala Glu Glu Lys Thr Val Gln Thr Gly Lys Thr Asp Gln 
        35                  40                  45              


Gln Val Gly Ala Lys Leu Val Gln Glu Ile Arg Glu Gly Lys Arg Gly 
    50                  55                  60                  


Pro Leu Tyr Ala Gly Tyr Phe Arg Thr Trp His Asp Arg Ala Ser Thr 
65                  70                  75                  80  


Gly Ile Asp Gly Lys Gln Gln His Pro Glu Asn Thr Met Ala Glu Val 
                85                  90                  95      


Pro Lys Glu Val Asp Ile Leu Phe Val Phe His Asp His Thr Ala Ser 
            100                 105                 110         


Asp Ser Pro Phe Trp Ser Glu Leu Lys Asp Ser Tyr Val His Lys Leu 
        115                 120                 125             


His Gln Gln Gly Thr Ala Leu Val Gln Thr Ile Gly Val Asn Glu Leu 
    130                 135                 140                 


Asn Gly Arg Thr Gly Leu Ser Lys Asp Tyr Pro Asp Thr Pro Glu Gly 
145                 150                 155                 160 


Asn Lys Ala Leu Ala Ala Ala Ile Val Lys Ala Phe Val Thr Asp Arg 
                165                 170                 175     


Gly Val Asp Gly Leu Asp Ile Cys Ile Glu His Glu Phe Thr Asn Lys 
            180                 185                 190         


Arg Thr Pro Glu Glu Asp Ala Arg Ala Leu Asn Val Phe Lys Glu Ile 
        195                 200                 205             


Ala Gln Leu Ile Gly Lys Asn Gly Ser Asp Lys Ser Lys Leu Leu Ile 
    210                 215                 220                 


Met Asp Thr Thr Leu Ser Val Glu Asn Asn Pro Ile Phe Lys Gly Ile 
225                 230                 235                 240 


Ala Glu Asp Leu Asp Tyr Leu Leu Arg Gln Tyr Tyr Gly Ser Gln Gly 
                245                 250                 255     


Gly Glu Ala Glu Val Asp Thr Ile Asn Ser Asp Trp Asn Gln Tyr Gln 
            260                 265                 270         


Asn Tyr Ile Asp Ala Ser Gln Phe Met Ile Gly Phe Ser Phe Phe Glu 
        275                 280                 285             


Glu Ser Ala Ser Lys Gly Asn Leu Trp Phe Asp Val Asn Glu Tyr Asp 
    290                 295                 300                 


Pro Asn Asn Pro Glu Lys Gly Lys Asp Ile Glu Gly Thr Arg Ala Lys 
305                 310                 315                 320 


Lys Tyr Ala Glu Trp Gln Pro Ser Thr Gly Gly Leu Lys Ala Gly Ile 
                325                 330                 335     


Phe Ser Tyr Ala Ile Asp Arg Asp Gly Val Ala His Val Pro Ser Thr 
            340                 345                 350         


Tyr Lys Asn Arg Thr Ser Thr Asn Leu Gln Arg His Glu Val Asp Asn 
        355                 360                 365             


Ile Ser His Thr Asp Tyr Thr Val Ser Arg Lys Leu Lys Thr Leu Met 
    370                 375                 380                 


Thr Glu Asp Lys Arg Tyr Asp Val Ile Asp Gln Lys Asp Ile Pro Asp 
385                 390                 395                 400 


Pro Ala Leu Arg Glu Gln Ile Ile Gln Gln Val Gly Gln Tyr Lys Gly 
                405                 410                 415     


Asp Leu Glu Arg Tyr Asn Lys Thr Leu Val Leu Thr Gly Asp Lys Ile 
            420                 425                 430         


Gln Asn Leu Lys Gly Leu Glu Lys Leu Ser Lys Leu Gln Lys Leu Glu 
        435                 440                 445             


Leu Arg Gln Leu Ser Asn Val Lys Glu Ile Thr Pro Glu Leu Leu Pro 
    450                 455                 460                 


Glu Ser Met Lys Lys Asp Ala Glu Leu Val Met Val Gly Met Thr Gly 
465                 470                 475                 480 


Leu Glu Lys Leu Asn Leu Ser Gly Leu Asn Arg Gln Thr Leu Asp Gly 
                485                 490                 495     


Ile Asp Val Asn Ser Ile Thr His Leu Thr Ser Phe Asp Ile Ser His 
            500                 505                 510         


Asn Ser Leu Asp Leu Ser Glu Lys Ser Glu Asp Arg Lys Leu Leu Met 
        515                 520                 525             


Thr Leu Met Glu Gln Val Ser Asn His Gln Lys Ile Thr Val Lys Asn 
    530                 535                 540                 


Thr Ala Phe Glu Asn Gln Lys Pro Lys Gly Tyr Tyr Pro Gln Thr Tyr 
545                 550                 555                 560 


Asp Thr Lys Glu Gly His Tyr Asp Val Asp Asn Ala Glu His Asp Ile 
                565                 570                 575     


Leu Thr Asp Phe Val Phe Gly Thr Val Thr Lys Arg Asn Thr Phe Ile 
            580                 585                 590         


Gly Asp Glu Glu Ala Phe Ala Ile Tyr Lys Glu Gly Ala Val Asp Gly 
        595                 600                 605             


Arg Gln Tyr Val Ser Lys Asp Tyr Thr Tyr Glu Ala Phe Arg Lys Asp 
    610                 615                 620                 


Tyr Lys Gly Tyr Lys Val His Leu Thr Ala Ser Asn Leu Gly Glu Thr 
625                 630                 635                 640 


Val Thr Ser Lys Val Thr Ala Thr Thr Asp Glu Thr Tyr Leu Val Asp 
                645                 650                 655     


Val Ser Asp Gly Glu Lys Val Val His His Met Lys Leu Asn Ile Gly 
            660                 665                 670         


Ser Gly Ala Ile Met Met Glu Asn Leu Ala Lys Gly Ala Lys Val Ile 
        675                 680                 685             


Gly Thr Ser Gly Asp Phe Glu Gln Ala Lys Lys Ile Phe Asp Gly Glu 
    690                 695                 700                 


Lys Ser Asp Arg Phe Phe Thr Trp Gly Gln Thr Asn Trp Ile Ala Phe 
705                 710                 715                 720 


Asp Leu Gly Glu Ile Asn Leu Ala Lys Glu Trp Arg Leu Phe Asn Ala 
                725                 730                 735     


Glu Thr Asn Thr Glu Ile Lys Thr Asp Ser Ser Leu Asn Val Ala Lys 
            740                 745                 750         


Gly Arg Leu Gln Ile Leu Lys Asp Thr Thr Ile Asp Leu Glu Lys Met 
        755                 760                 765             


Asp Ile Lys Asn Arg Lys Glu Tyr Leu Ser Asn Asp Glu Asn Trp Thr 
    770                 775                 780                 


Asp Val Ala Gln Met Asp Asp Ala Lys Ala Ile Phe Asn Ser Lys Leu 
785                 790                 795                 800 


Ser Asn Val Leu Ser Arg Tyr Trp Arg Phe Cys Val Asp Gly Gly Ala 
                805                 810                 815     


Ser Ser Tyr 
            


<210> 8
<211> 819
<212> PRT
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: 
      Synthetic polypeptide

<400> 8
Met Asp Lys His Leu Leu Val Lys Arg Thr Leu Gly Cys Val Cys Ala 
1               5                   10                  15      


Ala Thr Leu Met Gly Ala Ala Leu Ala Thr His His Asp Ser Leu Asn 
            20                  25                  30          


Thr Val Lys Ala Glu Glu Lys Thr Val Gln Thr Gly Lys Thr Asp Gln 
        35                  40                  45              


Gln Val Gly Ala Lys Leu Val Gln Glu Ile Arg Glu Gly Lys Arg Gly 
    50                  55                  60                  


Pro Leu Tyr Ala Gly Tyr Phe Arg Thr Trp His Asp Arg Ala Ser Thr 
65                  70                  75                  80  


Gly Ile Asp Gly Lys Gln Gln His Pro Glu Asn Thr Met Ala Glu Val 
                85                  90                  95      


Pro Lys Glu Val Asp Ile Leu Phe Val Phe His Asp His Thr Ala Ser 
            100                 105                 110         


Asp Ser Pro Phe Trp Ser Glu Leu Lys Asp Ser Tyr Val His Lys Leu 
        115                 120                 125             


His Gln Gln Gly Thr Ala Leu Val Gln Thr Ile Gly Val Asn Glu Leu 
    130                 135                 140                 


Asn Gly Arg Thr Gly Leu Ser Lys Asp Tyr Pro Asp Thr Pro Glu Gly 
145                 150                 155                 160 


Asn Lys Ala Leu Ala Ala Ala Ile Val Lys Ala Phe Val Thr Asp Arg 
                165                 170                 175     


Gly Val Asp Gly Leu Asp Ile Glu Ile Glu His Glu Phe Thr Asn Lys 
            180                 185                 190         


Arg Thr Pro Glu Glu Asp Ala Arg Ala Leu Asn Val Phe Lys Glu Ile 
        195                 200                 205             


Ala Gln Leu Ile Gly Lys Asn Gly Ser Asp Lys Ser Lys Leu Leu Ile 
    210                 215                 220                 


Met Asp Thr Thr Leu Ser Val Glu Asn Asn Pro Ile Phe Lys Gly Ile 
225                 230                 235                 240 


Ala Glu Asp Leu Asp Tyr Leu Leu Arg Gln Tyr Tyr Gly Ser Gln Gly 
                245                 250                 255     


Gly Glu Ala Glu Val Asp Thr Ile Asn Ser Asp Trp Asn Gln Tyr Gln 
            260                 265                 270         


Asn Tyr Ile Asp Ala Ser Gln Phe Met Ile Gly Phe Ser Phe Phe Glu 
        275                 280                 285             


Glu Ser Ala Ser Lys Gly Asn Leu Trp Phe Asp Val Asn Glu Tyr Asp 
    290                 295                 300                 


Pro Asn Asn Pro Glu Lys Gly Lys Asp Ile Glu Gly Thr Arg Ala Lys 
305                 310                 315                 320 


Lys Tyr Ala Glu Trp Gln Pro Ser Thr Gly Gly Leu Lys Ala Gly Ile 
                325                 330                 335     


Phe Ser Tyr Ala Ile Asp Arg Asp Gly Val Ala His Val Pro Ser Thr 
            340                 345                 350         


Tyr Lys Asn Arg Thr Ser Thr Asn Leu Gln Arg His Glu Val Asp Asn 
        355                 360                 365             


Ile Ser His Thr Asp Tyr Thr Val Ser Arg Lys Leu Lys Thr Leu Met 
    370                 375                 380                 


Thr Glu Asp Lys Arg Tyr Asp Val Ile Asp Gln Lys Asp Ile Pro Asp 
385                 390                 395                 400 


Pro Ala Leu Arg Glu Gln Ile Ile Gln Gln Val Gly Gln Tyr Lys Gly 
                405                 410                 415     


Asp Leu Glu Arg Tyr Asn Lys Thr Leu Val Leu Thr Gly Asp Lys Ile 
            420                 425                 430         


Gln Asn Leu Lys Gly Leu Glu Lys Leu Ser Lys Leu Gln Lys Leu Glu 
        435                 440                 445             


Leu Arg Gln Leu Ser Asn Val Lys Glu Ile Thr Pro Glu Leu Leu Pro 
    450                 455                 460                 


Glu Ser Met Lys Lys Asp Ala Glu Leu Val Met Val Gly Met Thr Gly 
465                 470                 475                 480 


Leu Glu Lys Leu Asn Leu Ser Gly Leu Asn Arg Gln Thr Leu Asp Gly 
                485                 490                 495     


Ile Asp Val Asn Ser Ile Thr His Leu Thr Ser Phe Asp Ile Ser His 
            500                 505                 510         


Asn Ser Leu Asp Leu Ser Glu Lys Ser Glu Asp Arg Lys Leu Leu Met 
        515                 520                 525             


Thr Leu Met Glu Gln Val Ser Asn His Gln Lys Ile Thr Val Lys Asn 
    530                 535                 540                 


Thr Ala Phe Glu Asn Gln Lys Pro Lys Gly Tyr Tyr Pro Gln Thr Tyr 
545                 550                 555                 560 


Asp Thr Lys Glu Gly His Tyr Asp Val Asp Asn Ala Glu His Asp Ile 
                565                 570                 575     


Leu Thr Asp Phe Val Phe Gly Thr Val Thr Lys Arg Asn Thr Phe Ile 
            580                 585                 590         


Gly Asp Glu Glu Ala Phe Ala Ile Tyr Lys Glu Gly Ala Val Asp Gly 
        595                 600                 605             


Arg Gln Tyr Val Ser Lys Asp Tyr Thr Tyr Glu Ala Phe Arg Lys Asp 
    610                 615                 620                 


Tyr Lys Gly Tyr Lys Val His Leu Thr Ala Ser Asn Leu Gly Glu Thr 
625                 630                 635                 640 


Val Thr Ser Lys Val Thr Ala Thr Thr Asp Glu Thr Tyr Leu Val Asp 
                645                 650                 655     


Val Ser Asp Gly Glu Lys Val Val His His Met Lys Leu Asn Ile Gly 
            660                 665                 670         


Ser Gly Ala Ile Met Met Glu Asn Leu Ala Lys Gly Ala Lys Val Ile 
        675                 680                 685             


Gly Thr Ser Gly Asp Phe Glu Gln Ala Lys Lys Ile Phe Asp Gly Glu 
    690                 695                 700                 


Lys Ser Asp Arg Phe Phe Thr Trp Gly Gln Thr Asn Trp Ile Ala Phe 
705                 710                 715                 720 


Asp Leu Gly Glu Ile Asn Leu Ala Lys Glu Trp Arg Leu Phe Asn Ala 
                725                 730                 735     


Glu Thr Asn Thr Glu Ile Lys Thr Asp Ser Ser Leu Asn Val Ala Lys 
            740                 745                 750         


Gly Arg Leu Gln Ile Leu Lys Asp Thr Thr Ile Asp Leu Glu Lys Met 
        755                 760                 765             


Asp Ile Lys Asn Arg Lys Glu Tyr Leu Ser Asn Asp Glu Asn Trp Thr 
    770                 775                 780                 


Asp Val Ala Gln Met Asp Asp Ala Lys Ala Ile Phe Asn Ser Lys Leu 
785                 790                 795                 800 


Ser Asn Val Leu Ser Arg Tyr Trp Arg Phe Cys Val Asp Gly Gly Ala 
                805                 810                 815     


Ser Ser Tyr 
            


<210> 9
<211> 819
<212> PRT
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: 
      Synthetic polypeptide

<400> 9
Met Asp Lys His Leu Leu Val Lys Arg Thr Leu Gly Cys Val Cys Ala 
1               5                   10                  15      


Ala Thr Leu Met Gly Ala Ala Leu Ala Thr His His Asp Ser Leu Asn 
            20                  25                  30          


Thr Val Lys Ala Glu Glu Lys Thr Val Gln Thr Gly Lys Thr Asp Gln 
        35                  40                  45              


Gln Val Gly Ala Lys Leu Val Gln Glu Ile Arg Glu Gly Lys Arg Gly 
    50                  55                  60                  


Pro Leu Tyr Ala Gly Tyr Phe Arg Thr Trp His Asp Arg Ala Ser Thr 
65                  70                  75                  80  


Gly Ile Asp Gly Lys Gln Gln His Pro Glu Asn Thr Met Ala Glu Val 
                85                  90                  95      


Pro Lys Glu Val Asp Ile Leu Phe Val Phe His Asp His Thr Ala Ser 
            100                 105                 110         


Asp Ser Pro Phe Trp Ser Glu Leu Lys Asp Ser Tyr Val His Lys Leu 
        115                 120                 125             


His Gln Gln Gly Thr Ala Leu Val Gln Thr Ile Gly Val Asn Glu Leu 
    130                 135                 140                 


Asn Gly Arg Thr Gly Leu Ser Lys Asp Tyr Pro Asp Thr Pro Glu Gly 
145                 150                 155                 160 


Asn Lys Ala Leu Ala Ala Ala Ile Val Lys Ala Phe Val Thr Asp Arg 
                165                 170                 175     


Gly Val Asp Gly Leu Asp Ile Gly Ile Glu His Glu Phe Thr Asn Lys 
            180                 185                 190         


Arg Thr Pro Glu Glu Asp Ala Arg Ala Leu Asn Val Phe Lys Glu Ile 
        195                 200                 205             


Ala Gln Leu Ile Gly Lys Asn Gly Ser Asp Lys Ser Lys Leu Leu Ile 
    210                 215                 220                 


Met Asp Thr Thr Leu Ser Val Glu Asn Asn Pro Ile Phe Lys Gly Ile 
225                 230                 235                 240 


Ala Glu Asp Leu Asp Tyr Leu Leu Arg Gln Tyr Tyr Gly Ser Gln Gly 
                245                 250                 255     


Gly Glu Ala Glu Val Asp Thr Ile Asn Ser Asp Trp Asn Gln Tyr Gln 
            260                 265                 270         


Asn Tyr Ile Asp Ala Ser Gln Phe Met Ile Gly Phe Ser Phe Phe Glu 
        275                 280                 285             


Glu Ser Ala Ser Lys Gly Asn Leu Trp Phe Asp Val Asn Glu Tyr Asp 
    290                 295                 300                 


Pro Asn Asn Pro Glu Lys Gly Lys Asp Ile Glu Gly Thr Arg Ala Lys 
305                 310                 315                 320 


Lys Tyr Ala Glu Trp Gln Pro Ser Thr Gly Gly Leu Lys Ala Gly Ile 
                325                 330                 335     


Phe Ser Tyr Ala Ile Asp Arg Asp Gly Val Ala His Val Pro Ser Thr 
            340                 345                 350         


Tyr Lys Asn Arg Thr Ser Thr Asn Leu Gln Arg His Glu Val Asp Asn 
        355                 360                 365             


Ile Ser His Thr Asp Tyr Thr Val Ser Arg Lys Leu Lys Thr Leu Met 
    370                 375                 380                 


Thr Glu Asp Lys Arg Tyr Asp Val Ile Asp Gln Lys Asp Ile Pro Asp 
385                 390                 395                 400 


Pro Ala Leu Arg Glu Gln Ile Ile Gln Gln Val Gly Gln Tyr Lys Gly 
                405                 410                 415     


Asp Leu Glu Arg Tyr Asn Lys Thr Leu Val Leu Thr Gly Asp Lys Ile 
            420                 425                 430         


Gln Asn Leu Lys Gly Leu Glu Lys Leu Ser Lys Leu Gln Lys Leu Glu 
        435                 440                 445             


Leu Arg Gln Leu Ser Asn Val Lys Glu Ile Thr Pro Glu Leu Leu Pro 
    450                 455                 460                 


Glu Ser Met Lys Lys Asp Ala Glu Leu Val Met Val Gly Met Thr Gly 
465                 470                 475                 480 


Leu Glu Lys Leu Asn Leu Ser Gly Leu Asn Arg Gln Thr Leu Asp Gly 
                485                 490                 495     


Ile Asp Val Asn Ser Ile Thr His Leu Thr Ser Phe Asp Ile Ser His 
            500                 505                 510         


Asn Ser Leu Asp Leu Ser Glu Lys Ser Glu Asp Arg Lys Leu Leu Met 
        515                 520                 525             


Thr Leu Met Glu Gln Val Ser Asn His Gln Lys Ile Thr Val Lys Asn 
    530                 535                 540                 


Thr Ala Phe Glu Asn Gln Lys Pro Lys Gly Tyr Tyr Pro Gln Thr Tyr 
545                 550                 555                 560 


Asp Thr Lys Glu Gly His Tyr Asp Val Asp Asn Ala Glu His Asp Ile 
                565                 570                 575     


Leu Thr Asp Phe Val Phe Gly Thr Val Thr Lys Arg Asn Thr Phe Ile 
            580                 585                 590         


Gly Asp Glu Glu Ala Phe Ala Ile Tyr Lys Glu Gly Ala Val Asp Gly 
        595                 600                 605             


Arg Gln Tyr Val Ser Lys Asp Tyr Thr Tyr Glu Ala Phe Arg Lys Asp 
    610                 615                 620                 


Tyr Lys Gly Tyr Lys Val His Leu Thr Ala Ser Asn Leu Gly Glu Thr 
625                 630                 635                 640 


Val Thr Ser Lys Val Thr Ala Thr Thr Asp Glu Thr Tyr Leu Val Asp 
                645                 650                 655     


Val Ser Asp Gly Glu Lys Val Val His His Met Lys Leu Asn Ile Gly 
            660                 665                 670         


Ser Gly Ala Ile Met Met Glu Asn Leu Ala Lys Gly Ala Lys Val Ile 
        675                 680                 685             


Gly Thr Ser Gly Asp Phe Glu Gln Ala Lys Lys Ile Phe Asp Gly Glu 
    690                 695                 700                 


Lys Ser Asp Arg Phe Phe Thr Trp Gly Gln Thr Asn Trp Ile Ala Phe 
705                 710                 715                 720 


Asp Leu Gly Glu Ile Asn Leu Ala Lys Glu Trp Arg Leu Phe Asn Ala 
                725                 730                 735     


Glu Thr Asn Thr Glu Ile Lys Thr Asp Ser Ser Leu Asn Val Ala Lys 
            740                 745                 750         


Gly Arg Leu Gln Ile Leu Lys Asp Thr Thr Ile Asp Leu Glu Lys Met 
        755                 760                 765             


Asp Ile Lys Asn Arg Lys Glu Tyr Leu Ser Asn Asp Glu Asn Trp Thr 
    770                 775                 780                 


Asp Val Ala Gln Met Asp Asp Ala Lys Ala Ile Phe Asn Ser Lys Leu 
785                 790                 795                 800 


Ser Asn Val Leu Ser Arg Tyr Trp Arg Phe Cys Val Asp Gly Gly Ala 
                805                 810                 815     


Ser Ser Tyr 
            


<210> 10
<211> 819
<212> PRT
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: 
      Synthetic polypeptide

<400> 10
Met Asp Lys His Leu Leu Val Lys Arg Thr Leu Gly Cys Val Cys Ala 
1               5                   10                  15      


Ala Thr Leu Met Gly Ala Ala Leu Ala Thr His His Asp Ser Leu Asn 
            20                  25                  30          


Thr Val Lys Ala Glu Glu Lys Thr Val Gln Thr Gly Lys Thr Asp Gln 
        35                  40                  45              


Gln Val Gly Ala Lys Leu Val Gln Glu Ile Arg Glu Gly Lys Arg Gly 
    50                  55                  60                  


Pro Leu Tyr Ala Gly Tyr Phe Arg Thr Trp His Asp Arg Ala Ser Thr 
65                  70                  75                  80  


Gly Ile Asp Gly Lys Gln Gln His Pro Glu Asn Thr Met Ala Glu Val 
                85                  90                  95      


Pro Lys Glu Val Asp Ile Leu Phe Val Phe His Asp His Thr Ala Ser 
            100                 105                 110         


Asp Ser Pro Phe Trp Ser Glu Leu Lys Asp Ser Tyr Val His Lys Leu 
        115                 120                 125             


His Gln Gln Gly Thr Ala Leu Val Gln Thr Ile Gly Val Asn Glu Leu 
    130                 135                 140                 


Asn Gly Arg Thr Gly Leu Ser Lys Asp Tyr Pro Asp Thr Pro Glu Gly 
145                 150                 155                 160 


Asn Lys Ala Leu Ala Ala Ala Ile Val Lys Ala Phe Val Thr Asp Arg 
                165                 170                 175     


Gly Val Asp Gly Leu Asp Ile Met Ile Glu His Glu Phe Thr Asn Lys 
            180                 185                 190         


Arg Thr Pro Glu Glu Asp Ala Arg Ala Leu Asn Val Phe Lys Glu Ile 
        195                 200                 205             


Ala Gln Leu Ile Gly Lys Asn Gly Ser Asp Lys Ser Lys Leu Leu Ile 
    210                 215                 220                 


Met Asp Thr Thr Leu Ser Val Glu Asn Asn Pro Ile Phe Lys Gly Ile 
225                 230                 235                 240 


Ala Glu Asp Leu Asp Tyr Leu Leu Arg Gln Tyr Tyr Gly Ser Gln Gly 
                245                 250                 255     


Gly Glu Ala Glu Val Asp Thr Ile Asn Ser Asp Trp Asn Gln Tyr Gln 
            260                 265                 270         


Asn Tyr Ile Asp Ala Ser Gln Phe Met Ile Gly Phe Ser Phe Phe Glu 
        275                 280                 285             


Glu Ser Ala Ser Lys Gly Asn Leu Trp Phe Asp Val Asn Glu Tyr Asp 
    290                 295                 300                 


Pro Asn Asn Pro Glu Lys Gly Lys Asp Ile Glu Gly Thr Arg Ala Lys 
305                 310                 315                 320 


Lys Tyr Ala Glu Trp Gln Pro Ser Thr Gly Gly Leu Lys Ala Gly Ile 
                325                 330                 335     


Phe Ser Tyr Ala Ile Asp Arg Asp Gly Val Ala His Val Pro Ser Thr 
            340                 345                 350         


Tyr Lys Asn Arg Thr Ser Thr Asn Leu Gln Arg His Glu Val Asp Asn 
        355                 360                 365             


Ile Ser His Thr Asp Tyr Thr Val Ser Arg Lys Leu Lys Thr Leu Met 
    370                 375                 380                 


Thr Glu Asp Lys Arg Tyr Asp Val Ile Asp Gln Lys Asp Ile Pro Asp 
385                 390                 395                 400 


Pro Ala Leu Arg Glu Gln Ile Ile Gln Gln Val Gly Gln Tyr Lys Gly 
                405                 410                 415     


Asp Leu Glu Arg Tyr Asn Lys Thr Leu Val Leu Thr Gly Asp Lys Ile 
            420                 425                 430         


Gln Asn Leu Lys Gly Leu Glu Lys Leu Ser Lys Leu Gln Lys Leu Glu 
        435                 440                 445             


Leu Arg Gln Leu Ser Asn Val Lys Glu Ile Thr Pro Glu Leu Leu Pro 
    450                 455                 460                 


Glu Ser Met Lys Lys Asp Ala Glu Leu Val Met Val Gly Met Thr Gly 
465                 470                 475                 480 


Leu Glu Lys Leu Asn Leu Ser Gly Leu Asn Arg Gln Thr Leu Asp Gly 
                485                 490                 495     


Ile Asp Val Asn Ser Ile Thr His Leu Thr Ser Phe Asp Ile Ser His 
            500                 505                 510         


Asn Ser Leu Asp Leu Ser Glu Lys Ser Glu Asp Arg Lys Leu Leu Met 
        515                 520                 525             


Thr Leu Met Glu Gln Val Ser Asn His Gln Lys Ile Thr Val Lys Asn 
    530                 535                 540                 


Thr Ala Phe Glu Asn Gln Lys Pro Lys Gly Tyr Tyr Pro Gln Thr Tyr 
545                 550                 555                 560 


Asp Thr Lys Glu Gly His Tyr Asp Val Asp Asn Ala Glu His Asp Ile 
                565                 570                 575     


Leu Thr Asp Phe Val Phe Gly Thr Val Thr Lys Arg Asn Thr Phe Ile 
            580                 585                 590         


Gly Asp Glu Glu Ala Phe Ala Ile Tyr Lys Glu Gly Ala Val Asp Gly 
        595                 600                 605             


Arg Gln Tyr Val Ser Lys Asp Tyr Thr Tyr Glu Ala Phe Arg Lys Asp 
    610                 615                 620                 


Tyr Lys Gly Tyr Lys Val His Leu Thr Ala Ser Asn Leu Gly Glu Thr 
625                 630                 635                 640 


Val Thr Ser Lys Val Thr Ala Thr Thr Asp Glu Thr Tyr Leu Val Asp 
                645                 650                 655     


Val Ser Asp Gly Glu Lys Val Val His His Met Lys Leu Asn Ile Gly 
            660                 665                 670         


Ser Gly Ala Ile Met Met Glu Asn Leu Ala Lys Gly Ala Lys Val Ile 
        675                 680                 685             


Gly Thr Ser Gly Asp Phe Glu Gln Ala Lys Lys Ile Phe Asp Gly Glu 
    690                 695                 700                 


Lys Ser Asp Arg Phe Phe Thr Trp Gly Gln Thr Asn Trp Ile Ala Phe 
705                 710                 715                 720 


Asp Leu Gly Glu Ile Asn Leu Ala Lys Glu Trp Arg Leu Phe Asn Ala 
                725                 730                 735     


Glu Thr Asn Thr Glu Ile Lys Thr Asp Ser Ser Leu Asn Val Ala Lys 
            740                 745                 750         


Gly Arg Leu Gln Ile Leu Lys Asp Thr Thr Ile Asp Leu Glu Lys Met 
        755                 760                 765             


Asp Ile Lys Asn Arg Lys Glu Tyr Leu Ser Asn Asp Glu Asn Trp Thr 
    770                 775                 780                 


Asp Val Ala Gln Met Asp Asp Ala Lys Ala Ile Phe Asn Ser Lys Leu 
785                 790                 795                 800 


Ser Asn Val Leu Ser Arg Tyr Trp Arg Phe Cys Val Asp Gly Gly Ala 
                805                 810                 815     


Ser Ser Tyr 
            


<210> 11
<211> 819
<212> PRT
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: 
      Synthetic polypeptide

<400> 11
Met Asp Lys His Leu Leu Val Lys Arg Thr Leu Gly Cys Val Cys Ala 
1               5                   10                  15      


Ala Thr Leu Met Gly Ala Ala Leu Ala Thr His His Asp Ser Leu Asn 
            20                  25                  30          


Thr Val Lys Ala Glu Glu Lys Thr Val Gln Thr Gly Lys Thr Asp Gln 
        35                  40                  45              


Gln Val Gly Ala Lys Leu Val Gln Glu Ile Arg Glu Gly Lys Arg Gly 
    50                  55                  60                  


Pro Leu Tyr Ala Gly Tyr Phe Arg Thr Trp His Asp Arg Ala Ser Thr 
65                  70                  75                  80  


Gly Ile Asp Gly Lys Gln Gln His Pro Glu Asn Thr Met Ala Glu Val 
                85                  90                  95      


Pro Lys Glu Val Asp Ile Leu Phe Val Phe His Asp His Thr Ala Ser 
            100                 105                 110         


Asp Ser Pro Phe Trp Ser Glu Leu Lys Asp Ser Tyr Val His Lys Leu 
        115                 120                 125             


His Gln Gln Gly Thr Ala Leu Val Gln Thr Ile Gly Val Asn Glu Leu 
    130                 135                 140                 


Asn Gly Arg Thr Gly Leu Ser Lys Asp Tyr Pro Asp Thr Pro Glu Gly 
145                 150                 155                 160 


Asn Lys Ala Leu Ala Ala Ala Ile Val Lys Ala Phe Val Thr Asp Arg 
                165                 170                 175     


Gly Val Asp Gly Leu Asp Ile Asn Ile Glu His Glu Phe Thr Asn Lys 
            180                 185                 190         


Arg Thr Pro Glu Glu Asp Ala Arg Ala Leu Asn Val Phe Lys Glu Ile 
        195                 200                 205             


Ala Gln Leu Ile Gly Lys Asn Gly Ser Asp Lys Ser Lys Leu Leu Ile 
    210                 215                 220                 


Met Asp Thr Thr Leu Ser Val Glu Asn Asn Pro Ile Phe Lys Gly Ile 
225                 230                 235                 240 


Ala Glu Asp Leu Asp Tyr Leu Leu Arg Gln Tyr Tyr Gly Ser Gln Gly 
                245                 250                 255     


Gly Glu Ala Glu Val Asp Thr Ile Asn Ser Asp Trp Asn Gln Tyr Gln 
            260                 265                 270         


Asn Tyr Ile Asp Ala Ser Gln Phe Met Ile Gly Phe Ser Phe Phe Glu 
        275                 280                 285             


Glu Ser Ala Ser Lys Gly Asn Leu Trp Phe Asp Val Asn Glu Tyr Asp 
    290                 295                 300                 


Pro Asn Asn Pro Glu Lys Gly Lys Asp Ile Glu Gly Thr Arg Ala Lys 
305                 310                 315                 320 


Lys Tyr Ala Glu Trp Gln Pro Ser Thr Gly Gly Leu Lys Ala Gly Ile 
                325                 330                 335     


Phe Ser Tyr Ala Ile Asp Arg Asp Gly Val Ala His Val Pro Ser Thr 
            340                 345                 350         


Tyr Lys Asn Arg Thr Ser Thr Asn Leu Gln Arg His Glu Val Asp Asn 
        355                 360                 365             


Ile Ser His Thr Asp Tyr Thr Val Ser Arg Lys Leu Lys Thr Leu Met 
    370                 375                 380                 


Thr Glu Asp Lys Arg Tyr Asp Val Ile Asp Gln Lys Asp Ile Pro Asp 
385                 390                 395                 400 


Pro Ala Leu Arg Glu Gln Ile Ile Gln Gln Val Gly Gln Tyr Lys Gly 
                405                 410                 415     


Asp Leu Glu Arg Tyr Asn Lys Thr Leu Val Leu Thr Gly Asp Lys Ile 
            420                 425                 430         


Gln Asn Leu Lys Gly Leu Glu Lys Leu Ser Lys Leu Gln Lys Leu Glu 
        435                 440                 445             


Leu Arg Gln Leu Ser Asn Val Lys Glu Ile Thr Pro Glu Leu Leu Pro 
    450                 455                 460                 


Glu Ser Met Lys Lys Asp Ala Glu Leu Val Met Val Gly Met Thr Gly 
465                 470                 475                 480 


Leu Glu Lys Leu Asn Leu Ser Gly Leu Asn Arg Gln Thr Leu Asp Gly 
                485                 490                 495     


Ile Asp Val Asn Ser Ile Thr His Leu Thr Ser Phe Asp Ile Ser His 
            500                 505                 510         


Asn Ser Leu Asp Leu Ser Glu Lys Ser Glu Asp Arg Lys Leu Leu Met 
        515                 520                 525             


Thr Leu Met Glu Gln Val Ser Asn His Gln Lys Ile Thr Val Lys Asn 
    530                 535                 540                 


Thr Ala Phe Glu Asn Gln Lys Pro Lys Gly Tyr Tyr Pro Gln Thr Tyr 
545                 550                 555                 560 


Asp Thr Lys Glu Gly His Tyr Asp Val Asp Asn Ala Glu His Asp Ile 
                565                 570                 575     


Leu Thr Asp Phe Val Phe Gly Thr Val Thr Lys Arg Asn Thr Phe Ile 
            580                 585                 590         


Gly Asp Glu Glu Ala Phe Ala Ile Tyr Lys Glu Gly Ala Val Asp Gly 
        595                 600                 605             


Arg Gln Tyr Val Ser Lys Asp Tyr Thr Tyr Glu Ala Phe Arg Lys Asp 
    610                 615                 620                 


Tyr Lys Gly Tyr Lys Val His Leu Thr Ala Ser Asn Leu Gly Glu Thr 
625                 630                 635                 640 


Val Thr Ser Lys Val Thr Ala Thr Thr Asp Glu Thr Tyr Leu Val Asp 
                645                 650                 655     


Val Ser Asp Gly Glu Lys Val Val His His Met Lys Leu Asn Ile Gly 
            660                 665                 670         


Ser Gly Ala Ile Met Met Glu Asn Leu Ala Lys Gly Ala Lys Val Ile 
        675                 680                 685             


Gly Thr Ser Gly Asp Phe Glu Gln Ala Lys Lys Ile Phe Asp Gly Glu 
    690                 695                 700                 


Lys Ser Asp Arg Phe Phe Thr Trp Gly Gln Thr Asn Trp Ile Ala Phe 
705                 710                 715                 720 


Asp Leu Gly Glu Ile Asn Leu Ala Lys Glu Trp Arg Leu Phe Asn Ala 
                725                 730                 735     


Glu Thr Asn Thr Glu Ile Lys Thr Asp Ser Ser Leu Asn Val Ala Lys 
            740                 745                 750         


Gly Arg Leu Gln Ile Leu Lys Asp Thr Thr Ile Asp Leu Glu Lys Met 
        755                 760                 765             


Asp Ile Lys Asn Arg Lys Glu Tyr Leu Ser Asn Asp Glu Asn Trp Thr 
    770                 775                 780                 


Asp Val Ala Gln Met Asp Asp Ala Lys Ala Ile Phe Asn Ser Lys Leu 
785                 790                 795                 800 


Ser Asn Val Leu Ser Arg Tyr Trp Arg Phe Cys Val Asp Gly Gly Ala 
                805                 810                 815     


Ser Ser Tyr 
            


<210> 12
<211> 819
<212> PRT
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: 
      Synthetic polypeptide

<400> 12
Met Asp Lys His Leu Leu Val Lys Arg Thr Leu Gly Cys Val Cys Ala 
1               5                   10                  15      


Ala Thr Leu Met Gly Ala Ala Leu Ala Thr His His Asp Ser Leu Asn 
            20                  25                  30          


Thr Val Lys Ala Glu Glu Lys Thr Val Gln Thr Gly Lys Thr Asp Gln 
        35                  40                  45              


Gln Val Gly Ala Lys Leu Val Gln Glu Ile Arg Glu Gly Lys Arg Gly 
    50                  55                  60                  


Pro Leu Tyr Ala Gly Tyr Phe Arg Thr Trp His Asp Arg Ala Ser Thr 
65                  70                  75                  80  


Gly Ile Asp Gly Lys Gln Gln His Pro Glu Asn Thr Met Ala Glu Val 
                85                  90                  95      


Pro Lys Glu Val Asp Ile Leu Phe Val Phe His Asp His Thr Ala Ser 
            100                 105                 110         


Asp Ser Pro Phe Trp Ser Glu Leu Lys Asp Ser Tyr Val His Lys Leu 
        115                 120                 125             


His Gln Gln Gly Thr Ala Leu Val Gln Thr Ile Gly Val Asn Glu Leu 
    130                 135                 140                 


Asn Gly Arg Thr Gly Leu Ser Lys Asp Tyr Pro Asp Thr Pro Glu Gly 
145                 150                 155                 160 


Asn Lys Ala Leu Ala Ala Ala Ile Val Lys Ala Phe Val Thr Asp Arg 
                165                 170                 175     


Gly Val Asp Gly Leu Asp Ile Gln Ile Glu His Glu Phe Thr Asn Lys 
            180                 185                 190         


Arg Thr Pro Glu Glu Asp Ala Arg Ala Leu Asn Val Phe Lys Glu Ile 
        195                 200                 205             


Ala Gln Leu Ile Gly Lys Asn Gly Ser Asp Lys Ser Lys Leu Leu Ile 
    210                 215                 220                 


Met Asp Thr Thr Leu Ser Val Glu Asn Asn Pro Ile Phe Lys Gly Ile 
225                 230                 235                 240 


Ala Glu Asp Leu Asp Tyr Leu Leu Arg Gln Tyr Tyr Gly Ser Gln Gly 
                245                 250                 255     


Gly Glu Ala Glu Val Asp Thr Ile Asn Ser Asp Trp Asn Gln Tyr Gln 
            260                 265                 270         


Asn Tyr Ile Asp Ala Ser Gln Phe Met Ile Gly Phe Ser Phe Phe Glu 
        275                 280                 285             


Glu Ser Ala Ser Lys Gly Asn Leu Trp Phe Asp Val Asn Glu Tyr Asp 
    290                 295                 300                 


Pro Asn Asn Pro Glu Lys Gly Lys Asp Ile Glu Gly Thr Arg Ala Lys 
305                 310                 315                 320 


Lys Tyr Ala Glu Trp Gln Pro Ser Thr Gly Gly Leu Lys Ala Gly Ile 
                325                 330                 335     


Phe Ser Tyr Ala Ile Asp Arg Asp Gly Val Ala His Val Pro Ser Thr 
            340                 345                 350         


Tyr Lys Asn Arg Thr Ser Thr Asn Leu Gln Arg His Glu Val Asp Asn 
        355                 360                 365             


Ile Ser His Thr Asp Tyr Thr Val Ser Arg Lys Leu Lys Thr Leu Met 
    370                 375                 380                 


Thr Glu Asp Lys Arg Tyr Asp Val Ile Asp Gln Lys Asp Ile Pro Asp 
385                 390                 395                 400 


Pro Ala Leu Arg Glu Gln Ile Ile Gln Gln Val Gly Gln Tyr Lys Gly 
                405                 410                 415     


Asp Leu Glu Arg Tyr Asn Lys Thr Leu Val Leu Thr Gly Asp Lys Ile 
            420                 425                 430         


Gln Asn Leu Lys Gly Leu Glu Lys Leu Ser Lys Leu Gln Lys Leu Glu 
        435                 440                 445             


Leu Arg Gln Leu Ser Asn Val Lys Glu Ile Thr Pro Glu Leu Leu Pro 
    450                 455                 460                 


Glu Ser Met Lys Lys Asp Ala Glu Leu Val Met Val Gly Met Thr Gly 
465                 470                 475                 480 


Leu Glu Lys Leu Asn Leu Ser Gly Leu Asn Arg Gln Thr Leu Asp Gly 
                485                 490                 495     


Ile Asp Val Asn Ser Ile Thr His Leu Thr Ser Phe Asp Ile Ser His 
            500                 505                 510         


Asn Ser Leu Asp Leu Ser Glu Lys Ser Glu Asp Arg Lys Leu Leu Met 
        515                 520                 525             


Thr Leu Met Glu Gln Val Ser Asn His Gln Lys Ile Thr Val Lys Asn 
    530                 535                 540                 


Thr Ala Phe Glu Asn Gln Lys Pro Lys Gly Tyr Tyr Pro Gln Thr Tyr 
545                 550                 555                 560 


Asp Thr Lys Glu Gly His Tyr Asp Val Asp Asn Ala Glu His Asp Ile 
                565                 570                 575     


Leu Thr Asp Phe Val Phe Gly Thr Val Thr Lys Arg Asn Thr Phe Ile 
            580                 585                 590         


Gly Asp Glu Glu Ala Phe Ala Ile Tyr Lys Glu Gly Ala Val Asp Gly 
        595                 600                 605             


Arg Gln Tyr Val Ser Lys Asp Tyr Thr Tyr Glu Ala Phe Arg Lys Asp 
    610                 615                 620                 


Tyr Lys Gly Tyr Lys Val His Leu Thr Ala Ser Asn Leu Gly Glu Thr 
625                 630                 635                 640 


Val Thr Ser Lys Val Thr Ala Thr Thr Asp Glu Thr Tyr Leu Val Asp 
                645                 650                 655     


Val Ser Asp Gly Glu Lys Val Val His His Met Lys Leu Asn Ile Gly 
            660                 665                 670         


Ser Gly Ala Ile Met Met Glu Asn Leu Ala Lys Gly Ala Lys Val Ile 
        675                 680                 685             


Gly Thr Ser Gly Asp Phe Glu Gln Ala Lys Lys Ile Phe Asp Gly Glu 
    690                 695                 700                 


Lys Ser Asp Arg Phe Phe Thr Trp Gly Gln Thr Asn Trp Ile Ala Phe 
705                 710                 715                 720 


Asp Leu Gly Glu Ile Asn Leu Ala Lys Glu Trp Arg Leu Phe Asn Ala 
                725                 730                 735     


Glu Thr Asn Thr Glu Ile Lys Thr Asp Ser Ser Leu Asn Val Ala Lys 
            740                 745                 750         


Gly Arg Leu Gln Ile Leu Lys Asp Thr Thr Ile Asp Leu Glu Lys Met 
        755                 760                 765             


Asp Ile Lys Asn Arg Lys Glu Tyr Leu Ser Asn Asp Glu Asn Trp Thr 
    770                 775                 780                 


Asp Val Ala Gln Met Asp Asp Ala Lys Ala Ile Phe Asn Ser Lys Leu 
785                 790                 795                 800 


Ser Asn Val Leu Ser Arg Tyr Trp Arg Phe Cys Val Asp Gly Gly Ala 
                805                 810                 815     


Ser Ser Tyr 
            


<210> 13
<211> 819
<212> PRT
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: 
      Synthetic polypeptide

<400> 13
Met Asp Lys His Leu Leu Val Lys Arg Thr Leu Gly Cys Val Cys Ala 
1               5                   10                  15      


Ala Thr Leu Met Gly Ala Ala Leu Ala Thr His His Asp Ser Leu Asn 
            20                  25                  30          


Thr Val Lys Ala Glu Glu Lys Thr Val Gln Thr Gly Lys Thr Asp Gln 
        35                  40                  45              


Gln Val Gly Ala Lys Leu Val Gln Glu Ile Arg Glu Gly Lys Arg Gly 
    50                  55                  60                  


Pro Leu Tyr Ala Gly Tyr Phe Arg Thr Trp His Asp Arg Ala Ser Thr 
65                  70                  75                  80  


Gly Ile Asp Gly Lys Gln Gln His Pro Glu Asn Thr Met Ala Glu Val 
                85                  90                  95      


Pro Lys Glu Val Asp Ile Leu Phe Val Phe His Asp His Thr Ala Ser 
            100                 105                 110         


Asp Ser Pro Phe Trp Ser Glu Leu Lys Asp Ser Tyr Val His Lys Leu 
        115                 120                 125             


His Gln Gln Gly Thr Ala Leu Val Gln Thr Ile Gly Val Asn Glu Leu 
    130                 135                 140                 


Asn Gly Arg Thr Gly Leu Ser Lys Asp Tyr Pro Asp Thr Pro Glu Gly 
145                 150                 155                 160 


Asn Lys Ala Leu Ala Ala Ala Ile Val Lys Ala Phe Val Thr Asp Arg 
                165                 170                 175     


Gly Val Asp Gly Leu Asp Ile Ser Ile Glu His Glu Phe Thr Asn Lys 
            180                 185                 190         


Arg Thr Pro Glu Glu Asp Ala Arg Ala Leu Asn Val Phe Lys Glu Ile 
        195                 200                 205             


Ala Gln Leu Ile Gly Lys Asn Gly Ser Asp Lys Ser Lys Leu Leu Ile 
    210                 215                 220                 


Met Asp Thr Thr Leu Ser Val Glu Asn Asn Pro Ile Phe Lys Gly Ile 
225                 230                 235                 240 


Ala Glu Asp Leu Asp Tyr Leu Leu Arg Gln Tyr Tyr Gly Ser Gln Gly 
                245                 250                 255     


Gly Glu Ala Glu Val Asp Thr Ile Asn Ser Asp Trp Asn Gln Tyr Gln 
            260                 265                 270         


Asn Tyr Ile Asp Ala Ser Gln Phe Met Ile Gly Phe Ser Phe Phe Glu 
        275                 280                 285             


Glu Ser Ala Ser Lys Gly Asn Leu Trp Phe Asp Val Asn Glu Tyr Asp 
    290                 295                 300                 


Pro Asn Asn Pro Glu Lys Gly Lys Asp Ile Glu Gly Thr Arg Ala Lys 
305                 310                 315                 320 


Lys Tyr Ala Glu Trp Gln Pro Ser Thr Gly Gly Leu Lys Ala Gly Ile 
                325                 330                 335     


Phe Ser Tyr Ala Ile Asp Arg Asp Gly Val Ala His Val Pro Ser Thr 
            340                 345                 350         


Tyr Lys Asn Arg Thr Ser Thr Asn Leu Gln Arg His Glu Val Asp Asn 
        355                 360                 365             


Ile Ser His Thr Asp Tyr Thr Val Ser Arg Lys Leu Lys Thr Leu Met 
    370                 375                 380                 


Thr Glu Asp Lys Arg Tyr Asp Val Ile Asp Gln Lys Asp Ile Pro Asp 
385                 390                 395                 400 


Pro Ala Leu Arg Glu Gln Ile Ile Gln Gln Val Gly Gln Tyr Lys Gly 
                405                 410                 415     


Asp Leu Glu Arg Tyr Asn Lys Thr Leu Val Leu Thr Gly Asp Lys Ile 
            420                 425                 430         


Gln Asn Leu Lys Gly Leu Glu Lys Leu Ser Lys Leu Gln Lys Leu Glu 
        435                 440                 445             


Leu Arg Gln Leu Ser Asn Val Lys Glu Ile Thr Pro Glu Leu Leu Pro 
    450                 455                 460                 


Glu Ser Met Lys Lys Asp Ala Glu Leu Val Met Val Gly Met Thr Gly 
465                 470                 475                 480 


Leu Glu Lys Leu Asn Leu Ser Gly Leu Asn Arg Gln Thr Leu Asp Gly 
                485                 490                 495     


Ile Asp Val Asn Ser Ile Thr His Leu Thr Ser Phe Asp Ile Ser His 
            500                 505                 510         


Asn Ser Leu Asp Leu Ser Glu Lys Ser Glu Asp Arg Lys Leu Leu Met 
        515                 520                 525             


Thr Leu Met Glu Gln Val Ser Asn His Gln Lys Ile Thr Val Lys Asn 
    530                 535                 540                 


Thr Ala Phe Glu Asn Gln Lys Pro Lys Gly Tyr Tyr Pro Gln Thr Tyr 
545                 550                 555                 560 


Asp Thr Lys Glu Gly His Tyr Asp Val Asp Asn Ala Glu His Asp Ile 
                565                 570                 575     


Leu Thr Asp Phe Val Phe Gly Thr Val Thr Lys Arg Asn Thr Phe Ile 
            580                 585                 590         


Gly Asp Glu Glu Ala Phe Ala Ile Tyr Lys Glu Gly Ala Val Asp Gly 
        595                 600                 605             


Arg Gln Tyr Val Ser Lys Asp Tyr Thr Tyr Glu Ala Phe Arg Lys Asp 
    610                 615                 620                 


Tyr Lys Gly Tyr Lys Val His Leu Thr Ala Ser Asn Leu Gly Glu Thr 
625                 630                 635                 640 


Val Thr Ser Lys Val Thr Ala Thr Thr Asp Glu Thr Tyr Leu Val Asp 
                645                 650                 655     


Val Ser Asp Gly Glu Lys Val Val His His Met Lys Leu Asn Ile Gly 
            660                 665                 670         


Ser Gly Ala Ile Met Met Glu Asn Leu Ala Lys Gly Ala Lys Val Ile 
        675                 680                 685             


Gly Thr Ser Gly Asp Phe Glu Gln Ala Lys Lys Ile Phe Asp Gly Glu 
    690                 695                 700                 


Lys Ser Asp Arg Phe Phe Thr Trp Gly Gln Thr Asn Trp Ile Ala Phe 
705                 710                 715                 720 


Asp Leu Gly Glu Ile Asn Leu Ala Lys Glu Trp Arg Leu Phe Asn Ala 
                725                 730                 735     


Glu Thr Asn Thr Glu Ile Lys Thr Asp Ser Ser Leu Asn Val Ala Lys 
            740                 745                 750         


Gly Arg Leu Gln Ile Leu Lys Asp Thr Thr Ile Asp Leu Glu Lys Met 
        755                 760                 765             


Asp Ile Lys Asn Arg Lys Glu Tyr Leu Ser Asn Asp Glu Asn Trp Thr 
    770                 775                 780                 


Asp Val Ala Gln Met Asp Asp Ala Lys Ala Ile Phe Asn Ser Lys Leu 
785                 790                 795                 800 


Ser Asn Val Leu Ser Arg Tyr Trp Arg Phe Cys Val Asp Gly Gly Ala 
                805                 810                 815     


Ser Ser Tyr 
            


<210> 14
<211> 819
<212> PRT
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: 
      Synthetic polypeptide

<400> 14
Met Asp Lys His Leu Leu Val Lys Arg Thr Leu Gly Cys Val Cys Ala 
1               5                   10                  15      


Ala Thr Leu Met Gly Ala Ala Leu Ala Thr His His Asp Ser Leu Asn 
            20                  25                  30          


Thr Val Lys Ala Glu Glu Lys Thr Val Gln Thr Gly Lys Thr Asp Gln 
        35                  40                  45              


Gln Val Gly Ala Lys Leu Val Gln Glu Ile Arg Glu Gly Lys Arg Gly 
    50                  55                  60                  


Pro Leu Tyr Ala Gly Tyr Phe Arg Thr Trp His Asp Arg Ala Ser Thr 
65                  70                  75                  80  


Gly Ile Asp Gly Lys Gln Gln His Pro Glu Asn Thr Met Ala Glu Val 
                85                  90                  95      


Pro Lys Glu Val Asp Ile Leu Phe Val Phe His Asp His Thr Ala Ser 
            100                 105                 110         


Asp Ser Pro Phe Trp Ser Glu Leu Lys Asp Ser Tyr Val His Lys Leu 
        115                 120                 125             


His Gln Gln Gly Thr Ala Leu Val Gln Thr Ile Gly Val Asn Glu Leu 
    130                 135                 140                 


Asn Gly Arg Thr Gly Leu Ser Lys Asp Tyr Pro Asp Thr Pro Glu Gly 
145                 150                 155                 160 


Asn Lys Ala Leu Ala Ala Ala Ile Val Lys Ala Phe Val Thr Asp Arg 
                165                 170                 175     


Gly Val Asp Gly Leu Asp Ile Thr Ile Glu His Glu Phe Thr Asn Lys 
            180                 185                 190         


Arg Thr Pro Glu Glu Asp Ala Arg Ala Leu Asn Val Phe Lys Glu Ile 
        195                 200                 205             


Ala Gln Leu Ile Gly Lys Asn Gly Ser Asp Lys Ser Lys Leu Leu Ile 
    210                 215                 220                 


Met Asp Thr Thr Leu Ser Val Glu Asn Asn Pro Ile Phe Lys Gly Ile 
225                 230                 235                 240 


Ala Glu Asp Leu Asp Tyr Leu Leu Arg Gln Tyr Tyr Gly Ser Gln Gly 
                245                 250                 255     


Gly Glu Ala Glu Val Asp Thr Ile Asn Ser Asp Trp Asn Gln Tyr Gln 
            260                 265                 270         


Asn Tyr Ile Asp Ala Ser Gln Phe Met Ile Gly Phe Ser Phe Phe Glu 
        275                 280                 285             


Glu Ser Ala Ser Lys Gly Asn Leu Trp Phe Asp Val Asn Glu Tyr Asp 
    290                 295                 300                 


Pro Asn Asn Pro Glu Lys Gly Lys Asp Ile Glu Gly Thr Arg Ala Lys 
305                 310                 315                 320 


Lys Tyr Ala Glu Trp Gln Pro Ser Thr Gly Gly Leu Lys Ala Gly Ile 
                325                 330                 335     


Phe Ser Tyr Ala Ile Asp Arg Asp Gly Val Ala His Val Pro Ser Thr 
            340                 345                 350         


Tyr Lys Asn Arg Thr Ser Thr Asn Leu Gln Arg His Glu Val Asp Asn 
        355                 360                 365             


Ile Ser His Thr Asp Tyr Thr Val Ser Arg Lys Leu Lys Thr Leu Met 
    370                 375                 380                 


Thr Glu Asp Lys Arg Tyr Asp Val Ile Asp Gln Lys Asp Ile Pro Asp 
385                 390                 395                 400 


Pro Ala Leu Arg Glu Gln Ile Ile Gln Gln Val Gly Gln Tyr Lys Gly 
                405                 410                 415     


Asp Leu Glu Arg Tyr Asn Lys Thr Leu Val Leu Thr Gly Asp Lys Ile 
            420                 425                 430         


Gln Asn Leu Lys Gly Leu Glu Lys Leu Ser Lys Leu Gln Lys Leu Glu 
        435                 440                 445             


Leu Arg Gln Leu Ser Asn Val Lys Glu Ile Thr Pro Glu Leu Leu Pro 
    450                 455                 460                 


Glu Ser Met Lys Lys Asp Ala Glu Leu Val Met Val Gly Met Thr Gly 
465                 470                 475                 480 


Leu Glu Lys Leu Asn Leu Ser Gly Leu Asn Arg Gln Thr Leu Asp Gly 
                485                 490                 495     


Ile Asp Val Asn Ser Ile Thr His Leu Thr Ser Phe Asp Ile Ser His 
            500                 505                 510         


Asn Ser Leu Asp Leu Ser Glu Lys Ser Glu Asp Arg Lys Leu Leu Met 
        515                 520                 525             


Thr Leu Met Glu Gln Val Ser Asn His Gln Lys Ile Thr Val Lys Asn 
    530                 535                 540                 


Thr Ala Phe Glu Asn Gln Lys Pro Lys Gly Tyr Tyr Pro Gln Thr Tyr 
545                 550                 555                 560 


Asp Thr Lys Glu Gly His Tyr Asp Val Asp Asn Ala Glu His Asp Ile 
                565                 570                 575     


Leu Thr Asp Phe Val Phe Gly Thr Val Thr Lys Arg Asn Thr Phe Ile 
            580                 585                 590         


Gly Asp Glu Glu Ala Phe Ala Ile Tyr Lys Glu Gly Ala Val Asp Gly 
        595                 600                 605             


Arg Gln Tyr Val Ser Lys Asp Tyr Thr Tyr Glu Ala Phe Arg Lys Asp 
    610                 615                 620                 


Tyr Lys Gly Tyr Lys Val His Leu Thr Ala Ser Asn Leu Gly Glu Thr 
625                 630                 635                 640 


Val Thr Ser Lys Val Thr Ala Thr Thr Asp Glu Thr Tyr Leu Val Asp 
                645                 650                 655     


Val Ser Asp Gly Glu Lys Val Val His His Met Lys Leu Asn Ile Gly 
            660                 665                 670         


Ser Gly Ala Ile Met Met Glu Asn Leu Ala Lys Gly Ala Lys Val Ile 
        675                 680                 685             


Gly Thr Ser Gly Asp Phe Glu Gln Ala Lys Lys Ile Phe Asp Gly Glu 
    690                 695                 700                 


Lys Ser Asp Arg Phe Phe Thr Trp Gly Gln Thr Asn Trp Ile Ala Phe 
705                 710                 715                 720 


Asp Leu Gly Glu Ile Asn Leu Ala Lys Glu Trp Arg Leu Phe Asn Ala 
                725                 730                 735     


Glu Thr Asn Thr Glu Ile Lys Thr Asp Ser Ser Leu Asn Val Ala Lys 
            740                 745                 750         


Gly Arg Leu Gln Ile Leu Lys Asp Thr Thr Ile Asp Leu Glu Lys Met 
        755                 760                 765             


Asp Ile Lys Asn Arg Lys Glu Tyr Leu Ser Asn Asp Glu Asn Trp Thr 
    770                 775                 780                 


Asp Val Ala Gln Met Asp Asp Ala Lys Ala Ile Phe Asn Ser Lys Leu 
785                 790                 795                 800 


Ser Asn Val Leu Ser Arg Tyr Trp Arg Phe Cys Val Asp Gly Gly Ala 
                805                 810                 815     


Ser Ser Tyr 
            


<210> 15
<211> 995
<212> PRT
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: 
      Synthetic polypeptide

<400> 15
Met Asp Lys His Leu Leu Val Lys Arg Thr Leu Gly Cys Val Cys Ala 
1               5                   10                  15      


Ala Thr Leu Met Gly Ala Ala Leu Ala Thr His His Asp Ser Leu Asn 
            20                  25                  30          


Thr Val Lys Ala Glu Glu Lys Thr Val Gln Val Gln Lys Gly Leu Pro 
        35                  40                  45              


Ser Ile Asp Ser Leu His Tyr Leu Ser Glu Asn Ser Lys Lys Glu Phe 
    50                  55                  60                  


Lys Glu Glu Leu Ser Lys Ala Gly Gln Glu Ser Gln Lys Val Lys Glu 
65                  70                  75                  80  


Ile Leu Ala Lys Ala Gln Gln Ala Asp Lys Gln Ala Gln Glu Leu Ala 
                85                  90                  95      


Lys Met Lys Ile Pro Glu Lys Ile Pro Met Lys Pro Leu His Gly Pro 
            100                 105                 110         


Leu Tyr Gly Gly Tyr Phe Arg Thr Trp His Asp Lys Thr Ser Asp Pro 
        115                 120                 125             


Thr Glu Lys Asp Lys Val Asn Ser Met Gly Glu Leu Pro Lys Glu Val 
    130                 135                 140                 


Asp Leu Ala Phe Ile Phe His Asp Trp Thr Lys Asp Tyr Ser Leu Phe 
145                 150                 155                 160 


Trp Lys Glu Leu Ala Thr Lys His Val Pro Lys Leu Asn Lys Gln Gly 
                165                 170                 175     


Thr Arg Val Ile Arg Thr Ile Pro Trp Arg Phe Leu Ala Gly Gly Asp 
            180                 185                 190         


Asn Ser Gly Ile Ala Glu Asp Thr Ser Lys Tyr Pro Asn Thr Pro Glu 
        195                 200                 205             


Gly Asn Lys Ala Leu Ala Lys Ala Ile Val Asp Glu Tyr Val Tyr Lys 
    210                 215                 220                 


Tyr Asn Leu Asp Gly Leu Asp Val Met Val Glu His Asp Ser Ile Pro 
225                 230                 235                 240 


Lys Val Asp Lys Lys Glu Asp Thr Ala Gly Val Glu Arg Ser Ile Gln 
                245                 250                 255     


Val Phe Glu Glu Ile Gly Lys Leu Ile Gly Pro Lys Gly Val Asp Lys 
            260                 265                 270         


Ser Arg Leu Phe Ile Met Asp Ser Thr Tyr Met Ala Asp Lys Asn Pro 
        275                 280                 285             


Leu Ile Glu Arg Gly Ala Pro Tyr Ile Asn Leu Leu Leu Val Gln Val 
    290                 295                 300                 


Tyr Gly Ser Gln Gly Glu Lys Gly Gly Trp Glu Pro Val Ser Asn Arg 
305                 310                 315                 320 


Pro Glu Lys Thr Met Glu Glu Arg Trp Gln Gly Tyr Ser Lys Tyr Ile 
                325                 330                 335     


Arg Pro Glu Gln Tyr Met Ile Gly Phe Ser Phe Tyr Glu Glu Asn Ala 
            340                 345                 350         


Gln Glu Gly Asn Leu Trp Tyr Asp Ile Asn Ser Arg Lys Asp Glu Asp 
        355                 360                 365             


Lys Ala Asn Gly Ile Asn Thr Asp Ile Thr Gly Thr Arg Ala Glu Arg 
    370                 375                 380                 


Tyr Ala Arg Trp Gln Pro Lys Thr Gly Gly Val Lys Gly Gly Ile Phe 
385                 390                 395                 400 


Ser Tyr Ala Ile Asp Arg Asp Gly Val Ala His Gln Pro Lys Lys Tyr 
                405                 410                 415     


Ala Lys Gln Lys Glu Phe Lys Asp Ala Thr Asp Asn Ile Phe His Ser 
            420                 425                 430         


Asp Tyr Ser Val Ser Lys Ala Leu Lys Thr Val Met Leu Lys Asp Lys 
        435                 440                 445             


Ser Tyr Asp Leu Ile Asp Glu Lys Asp Phe Pro Asp Lys Ala Leu Arg 
    450                 455                 460                 


Glu Ala Val Met Ala Gln Val Gly Thr Arg Lys Gly Asp Leu Glu Arg 
465                 470                 475                 480 


Phe Asn Gly Thr Leu Arg Leu Asp Asn Pro Ala Ile Gln Ser Leu Glu 
                485                 490                 495     


Gly Leu Asn Lys Phe Lys Lys Leu Ala Gln Leu Asp Leu Ile Gly Leu 
            500                 505                 510         


Ser Arg Ile Thr Lys Leu Asp Arg Ser Val Leu Pro Ala Asn Met Lys 
        515                 520                 525             


Pro Gly Lys Asp Thr Leu Glu Thr Val Leu Glu Thr Tyr Lys Lys Asp 
    530                 535                 540                 


Asn Lys Glu Glu Pro Ala Thr Ile Pro Pro Val Ser Leu Lys Val Ser 
545                 550                 555                 560 


Gly Leu Thr Gly Leu Lys Glu Leu Asp Leu Ser Gly Phe Asp Arg Glu 
                565                 570                 575     


Thr Leu Ala Gly Leu Asp Ala Ala Thr Leu Thr Ser Leu Glu Lys Val 
            580                 585                 590         


Asp Ile Ser Gly Asn Lys Leu Asp Leu Ala Pro Gly Thr Glu Asn Arg 
        595                 600                 605             


Gln Ile Phe Asp Thr Met Leu Ser Thr Ile Ser Asn His Val Gly Ser 
    610                 615                 620                 


Asn Glu Gln Thr Val Lys Phe Asp Lys Gln Lys Pro Thr Gly His Tyr 
625                 630                 635                 640 


Pro Asp Thr Tyr Gly Lys Thr Ser Leu Arg Leu Pro Val Ala Asn Glu 
                645                 650                 655     


Lys Val Asp Leu Gln Ser Gln Leu Leu Phe Gly Thr Val Thr Asn Gln 
            660                 665                 670         


Gly Thr Leu Ile Asn Ser Glu Ala Asp Tyr Lys Ala Tyr Gln Asn His 
        675                 680                 685             


Lys Ile Ala Gly Arg Ser Phe Val Asp Ser Asn Tyr His Tyr Asn Asn 
    690                 695                 700                 


Phe Lys Val Ser Tyr Glu Asn Tyr Thr Val Lys Val Thr Asp Ser Thr 
705                 710                 715                 720 


Leu Gly Thr Thr Thr Asp Lys Thr Leu Ala Thr Asp Lys Glu Glu Thr 
                725                 730                 735     


Tyr Lys Val Asp Phe Phe Ser Pro Ala Asp Lys Thr Lys Ala Val His 
            740                 745                 750         


Thr Ala Lys Val Ile Val Gly Asp Glu Lys Thr Met Met Val Asn Leu 
        755                 760                 765             


Ala Glu Gly Ala Thr Val Ile Gly Gly Ser Ala Asp Pro Val Asn Ala 
    770                 775                 780                 


Arg Lys Val Phe Asp Gly Gln Leu Gly Ser Glu Thr Asp Asn Ile Ser 
785                 790                 795                 800 


Leu Gly Trp Asp Ser Lys Gln Ser Ile Ile Phe Lys Leu Lys Glu Asp 
                805                 810                 815     


Gly Leu Ile Lys His Trp Arg Phe Phe Asn Asp Ser Ala Arg Asn Pro 
            820                 825                 830         


Glu Thr Thr Asn Lys Pro Ile Gln Glu Ala Ser Leu Gln Ile Phe Asn 
        835                 840                 845             


Ile Lys Asp Tyr Asn Leu Asp Asn Leu Leu Glu Asn Pro Asn Lys Phe 
    850                 855                 860                 


Asp Asp Glu Lys Tyr Trp Ile Thr Val Asp Thr Tyr Ser Ala Gln Gly 
865                 870                 875                 880 


Glu Arg Ala Thr Ala Phe Ser Asn Thr Leu Asn Asn Ile Thr Ser Lys 
                885                 890                 895     


Tyr Trp Arg Val Val Phe Asp Thr Lys Gly Asp Arg Tyr Ser Ser Pro 
            900                 905                 910         


Val Val Pro Glu Leu Gln Ile Leu Gly Tyr Pro Leu Pro Asn Ala Asp 
        915                 920                 925             


Thr Ile Met Lys Thr Val Thr Thr Ala Lys Glu Leu Ser Gln Gln Lys 
    930                 935                 940                 


Asp Lys Phe Ser Gln Lys Met Leu Asp Glu Leu Lys Ile Lys Glu Met 
945                 950                 955                 960 


Ala Leu Glu Thr Ser Leu Asn Ser Lys Ile Phe Asp Val Thr Ala Ile 
                965                 970                 975     


Asn Ala Asn Ala Gly Val Leu Lys Asp Cys Ile Glu Lys Arg Gln Leu 
            980                 985                 990         


Leu Lys Lys 
        995 


<210> 16
<211> 329
<212> PRT
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: 
      Synthetic polypeptide

<400> 16
Met Lys Lys Ile Phe Phe Ala Gln Cys Ser Ile Leu Leu Leu Met Leu 
1               5                   10                  15      


Gly Ser Cys Ser Lys Met Thr Glu Asp Met Thr Pro Glu Ser Val Asn 
            20                  25                  30          


Lys Glu Ala Ser Val Lys Ser Ala Thr Ala Leu Ala Gly Ser Asn Gly 
        35                  40                  45              


Val Cys Ile Ala Tyr Tyr Ile Thr Asp Gly Arg Asn Pro Thr Phe Lys 
    50                  55                  60                  


Leu Lys Asp Ile Pro Asp Lys Val Asp Met Val Ile Leu Phe Gly Leu 
65                  70                  75                  80  


Lys Tyr Trp Ser Leu Gln Asp Thr Thr Lys Leu Pro Gly Gly Thr Gly 
                85                  90                  95      


Met Met Gly Ser Phe Lys Ser Tyr Lys Asp Leu Asp Thr Gln Ile Arg 
            100                 105                 110         


Ser Leu Gln Ser Arg Gly Ile Lys Val Leu Gln Asn Ile Asp Asp Asp 
        115                 120                 125             


Val Ser Trp Gln Ser Ser Lys Pro Gly Gly Phe Ala Ser Ala Ala Ala 
    130                 135                 140                 


Tyr Gly Asp Ala Ile Lys Ser Ile Val Ile Asp Lys Trp Lys Leu Asp 
145                 150                 155                 160 


Gly Ile Ser Leu Ala Ile Glu His Ser Gly Ala Lys Pro Asn Pro Ile 
                165                 170                 175     


Pro Thr Phe Pro Gly Tyr Ala Ala Thr Gly Tyr Asn Gly Trp Tyr Ser 
            180                 185                 190         


Gly Ser Met Ala Ala Thr Pro Ala Phe Leu Asn Val Ile Ser Glu Leu 
        195                 200                 205             


Thr Lys Tyr Phe Gly Thr Thr Ala Pro Asn Asn Lys Gln Leu Gln Ile 
    210                 215                 220                 


Ala Ser Gly Ile Asp Val Tyr Ala Trp Asn Lys Ile Met Glu Asn Phe 
225                 230                 235                 240 


Arg Asn Asn Phe Asn Tyr Ile Gln Leu Gln Ser Tyr Gly Ala Asn Val 
                245                 250                 255     


Ser Arg Thr Gln Leu Met Met Asn Tyr Ala Thr Gly Thr Asn Lys Ile 
            260                 265                 270         


Pro Ala Ser Lys Met Val Phe Gly Ala Tyr Ala Glu Gly Gly Thr Asn 
        275                 280                 285             


Gln Ala Asn Asp Val Glu Val Ala Lys Trp Thr Pro Thr Gln Gly Ala 
    290                 295                 300                 


Lys Gly Gly Met Met Ile Tyr Thr Tyr Asn Ser Asn Val Ser Tyr Ala 
305                 310                 315                 320 


Asn Ala Val Arg Asp Ala Val Lys Asn 
                325                 


