                         SEQUENCE LISTING

<110>  Asimov Inc.
 
<120>  STABLE PRODUCTION SYSTEMS FOR LENTIVIRAL PRODUCTION

<130>  A1210.70003WO00

<140>  Not Yet Assigned
<141>  Concurrently Herewith

<150>  US 63/179,129
<151>  2021-04-23

<160>  28    

<170>  PatentIn version 3.5

<210>  1
<211>  346
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Synthetic

<400>  1
ctcgagttta ctccctatca gtgatagaga acgtatgtcg agtttactcc ctatcagtga       60

tagagaacga tgtcgagttt actccctatc agtgatagag aacgtatgtc gagtttactc      120

cctatcagtg atagagaacg tatgtcgagt ttactcccta tcagtgatag agaacgtatg      180

tcgagtttat ccctatcagt gatagagaac gtatgtcgag tttactccct atcagtgata      240

gagaacgtat gtcgaggtag gcgtgtacgg tgggaggcct atataagcag agctcgttta      300

gtgaaccgtc agatcgcctg gagaattcga gctcggtacc cgggga                     346


<210>  2
<211>  423
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Synthetic

<400>  2
gtttactccc tatcagtgat agagaacgta tgaagagttt actccctatc agtgatagag       60

aacgtatgca gactttactc cctatcagtg atagagaacg tataaggagt ttactcccta      120

tcagtgatag agaacgtatg accagtttac tccctatcag tgatagagaa cgtatctaca      180

gtttactccc tatcagtgat agagaacgta tatccagttt actccctatc agtgatagag      240

aacgtataag ctttaggcgt gtacggtggg cgcctataaa agcagagctc gtttagtgaa      300

ccgtcagatc gcctggagca attccacaac acttttgtct tataccaact ttccgtacca      360

cttcctaccc tcgtaaagtc gacaccgggg cccagatcta tcgatcggcc ggataacgcc      420

acc                                                                    423


<210>  3
<211>  496
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Synthetic

<400>  3
gaattctcca ggcgatctga cggttcacta aacgagctct gcttatatag gcctcccacc       60

gtacacgcca cctcgacata ctcgagttta ctccctatca gtgatagaga acgtatgaag      120

agtttactcc ctatcagtga tagagaacgt atgcagactt tactccctat cagtgataga      180

gaacgtataa ggagtttact ccctatcagt gatagagaac gtatgaccag tttactccct      240

atcagtgata gagaacgtat ctacagttta ctccctatca gtgatagaga acgtatatcc      300

agtttactcc ctatcagtga tagagaacgt ataagcttta ggcgtgtacg gtgggcgcct      360

ataaaagcag agctcgttta gtgaaccgtc agatcgcctg gagcaattcc acaacacttt      420

tgtcttatac caactttccg taccacttcc taccctcgta aagtcgacac cggggcccag      480

atctccgcgg ggatcc                                                      496


<210>  4
<211>  12
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Synthetic

<400>  4
attggatcca at                                                           12


<210>  5
<211>  28
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Synthetic

<400>  5
tatttacaaa caaccatgaa tgtaagta                                          28


<210>  6
<211>  18
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Synthetic

<400>  6
cggagtactg tcctccga                                                     18


<210>  7
<211>  30
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Synthetic

<400>  7
atgatacgaa acgtaccgta tcgttaaggt                                        30


<210>  8
<211>  26
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Synthetic

<400>  8
agaaacaaac caacctgtct gtatta                                            26


<210>  9
<211>  28
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Synthetic

<400>  9
aacaaacaga caatctggtc tgtttgta                                          28


<210>  10
<211>  249
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic

<400>  10

Met Ser Arg Leu Asp Lys Ser Lys Val Ile Asn Ser Ala Leu Glu Leu 
1               5                   10                  15      


Leu Asn Gly Val Gly Ile Glu Gly Leu Thr Thr Arg Lys Leu Ala Gln 
            20                  25                  30          


Lys Leu Gly Val Glu Gln Pro Thr Leu Tyr Trp His Val Lys Asn Lys 
        35                  40                  45              


Arg Ala Leu Leu Asp Ala Leu Pro Ile Glu Met Leu Asp Arg His His 
    50                  55                  60                  


Thr His Ser Cys Pro Leu Glu Gly Glu Ser Trp Gln Asp Phe Leu Arg 
65                  70                  75                  80  


Asn Asn Ala Lys Ser Tyr Arg Cys Ala Leu Leu Ser His Arg Asp Gly 
                85                  90                  95      


Ala Lys Val His Leu Gly Thr Arg Pro Thr Glu Lys Gln Tyr Glu Leu 
            100                 105                 110         


Thr Leu Glu Asn Gln Leu Ala Phe Leu Cys Gln Gln Gly Phe Ser Leu 
        115                 120                 125             


Glu Asn Ala Leu Tyr Ala Leu Ser Ala Val Gly His Phe Thr Leu Gly 
    130                 135                 140                 


Cys Val Leu Glu Glu Gln Glu His Gln Val Ala Lys Glu Glu Arg Glu 
145                 150                 155                 160 


Thr Pro Thr Thr Asp Ser Met Pro Pro Leu Leu Lys Gln Ala Ile Glu 
                165                 170                 175     


Leu Phe Asp Arg Gln Gly Ala Glu Pro Ala Phe Leu Phe Gly Leu Glu 
            180                 185                 190         


Leu Ile Ile Cys Gly Leu Glu Lys Gln Leu Lys Cys Glu Ser Gly Gly 
        195                 200                 205             


Pro Thr Asp Ala Leu Asp Asp Phe Asp Leu Asp Met Leu Pro Ala Asp 
    210                 215                 220                 


Ala Leu Asp Asp Phe Asp Leu Asp Met Leu Pro Ala Asp Ala Leu Asp 
225                 230                 235                 240 


Asp Phe Asp Leu Asp Met Leu Pro Gly 
                245                 


<210>  11
<211>  248
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic

<400>  11

Met Ser Arg Leu Asp Lys Ser Lys Val Ile Asn Ser Ala Leu Glu Leu 
1               5                   10                  15      


Leu Asn Glu Val Gly Ile Glu Gly Leu Thr Thr Arg Lys Leu Ala Gln 
            20                  25                  30          


Lys Leu Gly Val Glu Gln Pro Thr Leu Tyr Trp His Val Lys Asn Lys 
        35                  40                  45              


Arg Ala Leu Leu Asp Ala Leu Ala Ile Glu Met Leu Asp Arg His His 
    50                  55                  60                  


Thr His Phe Cys Pro Leu Glu Gly Glu Ser Trp Gln Asp Phe Leu Arg 
65                  70                  75                  80  


Asn Asn Ala Lys Ser Phe Arg Cys Ala Leu Leu Ser His Arg Asp Gly 
                85                  90                  95      


Ala Lys Val His Leu Gly Thr Arg Pro Thr Glu Lys Gln Tyr Glu Thr 
            100                 105                 110         


Leu Glu Asn Gln Leu Ala Phe Leu Cys Gln Gln Gly Phe Ser Leu Glu 
        115                 120                 125             


Asn Ala Leu Tyr Ala Leu Ser Ala Val Gly His Phe Thr Leu Gly Cys 
    130                 135                 140                 


Val Leu Glu Asp Gln Glu His Gln Val Ala Lys Glu Glu Arg Glu Thr 
145                 150                 155                 160 


Pro Thr Thr Asp Ser Met Pro Pro Leu Leu Arg Gln Ala Ile Glu Leu 
                165                 170                 175     


Phe Asp His Gln Gly Ala Glu Pro Ala Phe Leu Phe Gly Leu Glu Leu 
            180                 185                 190         


Ile Ile Cys Gly Leu Glu Lys Gln Leu Lys Cys Glu Ser Gly Gly Pro 
        195                 200                 205             


Ala Asp Ala Leu Asp Asp Phe Asp Leu Asp Met Leu Pro Ala Asp Ala 
    210                 215                 220                 


Leu Asp Asp Phe Asp Leu Asp Met Leu Pro Ala Asp Ala Leu Asp Asp 
225                 230                 235                 240 


Phe Asp Leu Asp Met Leu Pro Gly 
                245             


<210>  12
<211>  298
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic

<400>  12

Met Asp Met Pro Arg Ile Lys Pro Gly Gln Arg Val Met Met Ala Leu 
1               5                   10                  15      


Arg Lys Met Ile Ala Ser Gly Glu Ile Lys Ser Gly Glu Arg Ile Ala 
            20                  25                  30          


Glu Ile Pro Thr Ala Ala Ala Leu Gly Val Ser Arg Met Pro Val Arg 
        35                  40                  45              


Ile Ala Leu Arg Ser Leu Glu Gln Glu Gly Leu Val Val Arg Leu Gly 
    50                  55                  60                  


Ala Arg Gly Tyr Ala Ala Arg Gly Val Ser Ser Asp Gln Ile Arg Asp 
65                  70                  75                  80  


Ala Ile Glu Val Arg Gly Val Leu Glu Gly Phe Ala Ala Arg Arg Leu 
                85                  90                  95      


Ala Glu Arg Gly Met Thr Ala Glu Thr His Ala Arg Phe Val Val Leu 
            100                 105                 110         


Ile Ala Glu Gly Glu Ala Leu Phe Ala Ala Gly Arg Leu Asn Gly Glu 
        115                 120                 125             


Asp Leu Asp Arg Tyr Ala Ala Tyr Asn Gln Ala Phe His Asp Thr Leu 
    130                 135                 140                 


Val Ser Ala Ala Gly Asn Gly Ala Val Glu Ser Ala Leu Ala Arg Asn 
145                 150                 155                 160 


Gly Phe Glu Pro Phe Ala Ala Ala Gly Ala Leu Ala Leu Asp Leu Met 
                165                 170                 175     


Asp Leu Ser Ala Glu Tyr Glu His Leu Leu Ala Ala His Arg Gln His 
            180                 185                 190         


Gln Ala Val Leu Asp Ala Val Ser Cys Gly Asp Ala Glu Gly Ala Glu 
        195                 200                 205             


Arg Ile Met Arg Asp His Ala Leu Ala Ala Ile Arg Asn Ala Lys Val 
    210                 215                 220                 


Phe Glu Ala Ala Ala Ser Ala Gly Ala Pro Leu Gly Ala Ala Trp Ser 
225                 230                 235                 240 


Ile Arg Ala Asp Ser Gly Gly Gly Gly Pro Thr Asp Ala Leu Asp Asp 
                245                 250                 255     


Phe Asp Leu Asp Met Leu Pro Ala Asp Ala Leu Asp Asp Phe Asp Leu 
            260                 265                 270         


Asp Met Leu Pro Ala Asp Ala Leu Asp Asp Phe Asp Leu Asp Met Leu 
        275                 280                 285             


Pro Gly Pro Pro Lys Lys Lys Arg Lys Val 
    290                 295             


<210>  13
<211>  264
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic

<400>  13

Met Val Arg Arg Thr Lys Glu Glu Ala Gln Glu Thr Arg Ala Gln Ile 
1               5                   10                  15      


Ile Glu Ala Ala Glu Arg Ala Phe Tyr Lys Arg Gly Val Ala Arg Thr 
            20                  25                  30          


Thr Leu Ala Asp Ile Ala Glu Leu Ala Gly Val Thr Arg Gly Ala Ile 
        35                  40                  45              


Tyr Trp His Phe Asn Asn Lys Ala Glu Leu Val Gln Ala Leu Leu Asp 
    50                  55                  60                  


Ser Leu His Glu Thr His Asp His Leu Ala Arg Ala Ser Glu Ser Glu 
65                  70                  75                  80  


Asp Glu Val Asp Pro Leu Gly Cys Met Arg Lys Leu Leu Leu Gln Val 
                85                  90                  95      


Phe Asn Glu Leu Val Leu Asp Ala Arg Thr Arg Arg Ile Asn Glu Ile 
            100                 105                 110         


Leu His His Lys Cys Glu Phe Thr Asp Asp Met Cys Glu Ile Arg Gln 
        115                 120                 125             


Gln His Gln Ser Ala Val Leu Asp Cys His Lys Gly Ile Thr Leu Thr 
    130                 135                 140                 


Leu Ala Asn Val Val Arg Arg Gly Gln Leu Pro Gly Glu Leu Asp Ala 
145                 150                 155                 160 


Glu Arg Ala Ala Val Ala Met Phe Ala Tyr Val Asp Gly Leu Ile Arg 
                165                 170                 175     


Arg Trp Leu Leu Leu Pro Asp Ser Val Asp Leu Leu Gly Asp Val Glu 
            180                 185                 190         


Lys Trp Val Asp Thr Gly Leu Asp Met Leu Arg Leu Ser Pro Ala Leu 
        195                 200                 205             


Arg Lys Ser Gly Gly Gly Gly Pro Thr Asp Ala Leu Asp Asp Phe Asp 
    210                 215                 220                 


Leu Asp Met Leu Pro Ala Asp Ala Leu Asp Asp Phe Asp Leu Asp Met 
225                 230                 235                 240 


Leu Pro Ala Asp Ala Leu Asp Asp Phe Asp Leu Asp Met Leu Pro Gly 
                245                 250                 255     


Pro Pro Lys Lys Lys Arg Lys Val 
            260                 


<210>  14
<211>  254
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic

<400>  14

Met Ala Arg Thr Pro Ser Arg Ser Ser Ile Gly Ser Leu Arg Ser Pro 
1               5                   10                  15      


His Thr His Lys Ala Ile Leu Thr Ser Thr Ile Glu Ile Leu Lys Glu 
            20                  25                  30          


Cys Gly Tyr Ser Gly Leu Ser Ile Glu Ser Val Ala Arg Arg Ala Gly 
        35                  40                  45              


Ala Gly Lys Pro Thr Ile Tyr Arg Trp Trp Thr Asn Lys Ala Ala Leu 
    50                  55                  60                  


Ile Ala Glu Val Tyr Glu Asn Glu Ile Glu Gln Val Arg Lys Phe Pro 
65                  70                  75                  80  


Asp Leu Gly Ser Phe Lys Ala Asp Leu Asp Phe Leu Leu His Asn Leu 
                85                  90                  95      


Trp Lys Val Trp Arg Glu Thr Ile Cys Gly Glu Ala Phe Arg Cys Val 
            100                 105                 110         


Ile Ala Glu Ala Gln Leu Asp Pro Val Thr Leu Thr Gln Leu Lys Asp 
        115                 120                 125             


Gln Phe Met Glu Arg Arg Arg Glu Ile Pro Lys Lys Leu Val Glu Asp 
    130                 135                 140                 


Ala Ile Ser Asn Gly Glu Leu Pro Lys Asp Ile Asn Arg Glu Leu Leu 
145                 150                 155                 160 


Leu Asp Met Ile Phe Gly Phe Cys Trp Tyr Arg Leu Leu Thr Glu Gln 
                165                 170                 175     


Leu Thr Val Glu Gln Asp Ile Glu Glu Phe Thr Phe Leu Leu Ile Asn 
            180                 185                 190         


Gly Val Cys Pro Gly Thr Gln Cys Ser Gly Gly Gly Gly Pro Thr Asp 
        195                 200                 205             


Ala Leu Asp Asp Phe Asp Leu Asp Met Leu Pro Ala Asp Ala Leu Asp 
    210                 215                 220                 


Asp Phe Asp Leu Asp Met Leu Pro Ala Asp Ala Leu Asp Asp Phe Asp 
225                 230                 235                 240 


Leu Asp Met Leu Pro Gly Pro Pro Lys Lys Lys Arg Lys Val 
                245                 250                 


<210>  15
<211>  257
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic

<400>  15

Met Ser Pro Lys Arg Arg Thr Gln Ala Glu Arg Ala Met Glu Thr Gln 
1               5                   10                  15      


Gly Lys Leu Ile Ala Ala Ala Leu Gly Val Leu Arg Glu Lys Gly Tyr 
            20                  25                  30          


Ala Gly Phe Arg Ile Ala Asp Val Pro Gly Ala Ala Gly Val Ser Arg 
        35                  40                  45              


Gly Ala Gln Ser His His Phe Pro Thr Lys Leu Glu Leu Leu Leu Ala 
    50                  55                  60                  


Thr Phe Glu Trp Leu Tyr Glu Gln Ile Thr Glu Arg Ser Arg Ala Arg 
65                  70                  75                  80  


Leu Ala Lys Leu Lys Pro Glu Asp Asp Val Ile Gln Gln Met Leu Asp 
                85                  90                  95      


Asp Ala Ala Glu Phe Phe Leu Asp Asp Asp Phe Ser Ile Gly Leu Asp 
            100                 105                 110         


Leu Ile Val Ala Ala Asp Arg Asp Pro Ala Leu Arg Glu Gly Ile Gln 
        115                 120                 125             


Arg Thr Val Glu Arg Asn Arg Phe Val Val Glu Asp Met Trp Leu Gly 
    130                 135                 140                 


Val Leu Val Ser Arg Gly Leu Ser Arg Asp Asp Ala Glu Asp Ile Leu 
145                 150                 155                 160 


Trp Leu Ile Phe Asn Ser Val Arg Gly Leu Val Val Arg Ser Leu Trp 
                165                 170                 175     


Gln Lys Asp Lys Glu Arg Phe Glu Arg Val Arg Asn Ser Thr Leu Glu 
            180                 185                 190         


Ile Ala Arg Glu Arg Tyr Ala Lys Phe Lys Arg Ser Gly Gly Gly Gly 
        195                 200                 205             


Pro Thr Asp Ala Leu Asp Asp Phe Asp Leu Asp Met Leu Pro Ala Asp 
    210                 215                 220                 


Ala Leu Asp Asp Phe Asp Leu Asp Met Leu Pro Ala Asp Ala Leu Asp 
225                 230                 235                 240 


Asp Phe Asp Leu Asp Met Leu Pro Gly Pro Pro Lys Lys Lys Arg Lys 
                245                 250                 255     


Val 
    


<210>  16
<211>  260
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic

<400>  16

Met Val Ile Met Ser Pro Lys Arg Arg Thr Gln Ala Glu Arg Ala Met 
1               5                   10                  15      


Glu Thr Gln Gly Lys Leu Ile Ala Ala Ala Leu Gly Val Leu Arg Glu 
            20                  25                  30          


Lys Gly Tyr Ala Gly Phe Arg Ile Ala Asp Val Pro Gly Ala Ala Gly 
        35                  40                  45              


Val Ser Arg Gly Ala Gln Ser His His Phe Pro Thr Lys Leu Glu Leu 
    50                  55                  60                  


Leu Leu Ala Thr Phe Glu Trp Leu Tyr Glu Gln Ile Thr Glu Arg Ser 
65                  70                  75                  80  


Arg Ala Arg Leu Ala Lys Leu Lys Pro Glu Asp Asp Val Ile Gln Gln 
                85                  90                  95      


Met Leu Asp Asp Ala Ala Glu Phe Phe Leu Asp Asp Asp Phe Ser Ile 
            100                 105                 110         


Gly Leu Asp Leu Ile Val Ala Ala Asp Arg Asp Pro Val Leu Arg Glu 
        115                 120                 125             


Gly Ile Gln Arg Thr Val Glu Arg Asn Arg Phe Val Val Gly Asp Ile 
    130                 135                 140                 


Trp Leu Gly Val Leu Val Ser Arg Gly Leu Ser Arg Asp Asp Ala Glu 
145                 150                 155                 160 


Asp Ile Leu Trp Leu Ile Phe Asn Ser Val Arg Gly Leu Val Val Arg 
                165                 170                 175     


Ser Leu Trp Gln Lys Asp Lys Glu Arg Phe Glu Arg Val Arg Asn Ser 
            180                 185                 190         


Thr Leu Glu Ile Ala Arg Glu Arg Tyr Ala Lys Phe Lys Arg Ser Gly 
        195                 200                 205             


Gly Gly Gly Pro Thr Asp Ala Leu Asp Asp Phe Asp Leu Asp Met Leu 
    210                 215                 220                 


Pro Ala Asp Ala Leu Asp Asp Phe Asp Leu Asp Met Leu Pro Ala Asp 
225                 230                 235                 240 


Ala Leu Asp Asp Phe Asp Leu Asp Met Leu Pro Gly Pro Pro Lys Lys 
                245                 250                 255     


Lys Arg Lys Val 
            260 


<210>  17
<211>  432
<212>  PRT
<213>  Unknown

<220>
<223>  Lentivirus

<400>  17

Met Gly Ala Arg Ala Ser Val Leu Ser Gly Gly Glu Leu Asp Arg Trp 
1               5                   10                  15      


Glu Lys Ile Arg Leu Arg Pro Gly Gly Lys Lys Lys Tyr Lys Leu Lys 
            20                  25                  30          


His Ile Val Trp Ala Ser Arg Glu Leu Glu Arg Phe Ala Val Asn Pro 
        35                  40                  45              


Gly Leu Leu Glu Thr Ser Glu Gly Cys Arg Gln Ile Leu Gly Gln Leu 
    50                  55                  60                  


Gln Pro Ser Leu Gln Thr Gly Ser Glu Glu Leu Arg Ser Leu Tyr Asn 
65                  70                  75                  80  


Thr Val Ala Thr Leu Tyr Cys Val His Gln Arg Ile Glu Ile Lys Asp 
                85                  90                  95      


Thr Lys Glu Ala Leu Asp Lys Ile Glu Glu Glu Gln Asn Lys Ser Lys 
            100                 105                 110         


Lys Lys Ala Gln Gln Ala Ala Ala Asp Thr Gly His Ser Asn Gln Val 
        115                 120                 125             


Ser Gln Asn Tyr Pro Ile Val Gln Asn Ile Gln Gly Gln Met Val His 
    130                 135                 140                 


Gln Ala Ile Ser Pro Arg Thr Leu Asn Ala Trp Val Lys Val Val Glu 
145                 150                 155                 160 


Glu Lys Ala Phe Ser Pro Glu Val Ile Pro Met Phe Ser Ala Leu Ser 
                165                 170                 175     


Glu Gly Ala Thr Pro Gln Asp Leu Asn Thr Met Leu Asn Thr Val Gly 
            180                 185                 190         


Gly His Gln Ala Ala Met Gln Met Leu Lys Glu Thr Ile Asn Glu Glu 
        195                 200                 205             


Ala Ala Glu Trp Asp Arg Val His Pro Val His Ala Gly Pro Ile Ala 
    210                 215                 220                 


Pro Gly Gln Met Arg Glu Pro Arg Gly Ser Asp Ile Ala Gly Thr Thr 
225                 230                 235                 240 


Ser Thr Leu Gln Glu Gln Ile Gly Trp Met Thr His Asn Pro Pro Ile 
                245                 250                 255     


Pro Val Gly Glu Ile Tyr Lys Arg Trp Ile Ile Leu Gly Leu Asn Lys 
            260                 265                 270         


Ile Val Arg Met Tyr Ser Pro Thr Ser Ile Leu Asp Ile Arg Gln Gly 
        275                 280                 285             


Pro Lys Glu Pro Phe Arg Asp Tyr Val Asp Arg Phe Tyr Lys Thr Leu 
    290                 295                 300                 


Arg Ala Glu Gln Ala Ser Gln Glu Val Lys Asn Trp Met Thr Glu Thr 
305                 310                 315                 320 


Leu Leu Val Gln Asn Ala Asn Pro Asp Cys Lys Thr Ile Leu Lys Ala 
                325                 330                 335     


Leu Gly Pro Gly Ala Thr Leu Glu Glu Met Met Thr Ala Cys Gln Gly 
            340                 345                 350         


Val Gly Gly Pro Gly His Lys Ala Arg Val Leu Ala Glu Ala Met Ser 
        355                 360                 365             


Gln Val Thr Asn Pro Ala Thr Ile Met Ile Gln Lys Gly Asn Phe Arg 
    370                 375                 380                 


Asn Gln Arg Lys Thr Val Lys Cys Phe Asn Cys Gly Lys Glu Gly His 
385                 390                 395                 400 


Ile Ala Lys Asn Cys Arg Ala Pro Arg Lys Lys Gly Cys Trp Lys Cys 
                405                 410                 415     


Gly Lys Glu Gly His Gln Met Lys Asp Cys Thr Glu Arg Gln Ala Asn 
            420                 425                 430         


<210>  18
<211>  1003
<212>  PRT
<213>  Unknown

<220>
<223>  Lentivirus

<400>  18

Phe Phe Arg Glu Asp Leu Ala Phe Pro Gln Gly Lys Ala Arg Glu Phe 
1               5                   10                  15      


Ser Ser Glu Gln Thr Arg Ala Asn Ser Pro Thr Arg Arg Glu Leu Gln 
            20                  25                  30          


Val Trp Gly Arg Asp Asn Asn Ser Leu Ser Glu Ala Gly Ala Asp Arg 
        35                  40                  45              


Gln Gly Thr Val Ser Phe Ser Phe Pro Gln Ile Thr Leu Trp Gln Arg 
    50                  55                  60                  


Pro Leu Val Thr Ile Lys Ile Gly Gly Gln Leu Lys Glu Ala Leu Leu 
65                  70                  75                  80  


Asp Thr Gly Ala Asp Asp Thr Val Leu Glu Glu Met Asn Leu Pro Gly 
                85                  90                  95      


Arg Trp Lys Pro Lys Met Ile Gly Gly Ile Gly Gly Phe Ile Lys Val 
            100                 105                 110         


Arg Gln Tyr Asp Gln Ile Leu Ile Glu Ile Cys Gly His Lys Ala Ile 
        115                 120                 125             


Gly Thr Val Leu Val Gly Pro Thr Pro Val Asn Ile Ile Gly Arg Asn 
    130                 135                 140                 


Leu Leu Thr Gln Ile Gly Cys Thr Leu Asn Phe Pro Ile Ser Pro Ile 
145                 150                 155                 160 


Glu Thr Val Pro Val Lys Leu Lys Pro Gly Met Asp Gly Pro Lys Val 
                165                 170                 175     


Lys Gln Trp Pro Leu Thr Glu Glu Lys Ile Lys Ala Leu Val Glu Ile 
            180                 185                 190         


Cys Thr Glu Met Glu Lys Glu Gly Lys Ile Ser Lys Ile Gly Pro Glu 
        195                 200                 205             


Asn Pro Tyr Asn Thr Pro Val Phe Ala Ile Lys Lys Lys Asp Ser Thr 
    210                 215                 220                 


Lys Trp Arg Lys Leu Val Asp Phe Arg Glu Leu Asn Lys Arg Thr Gln 
225                 230                 235                 240 


Asp Phe Trp Glu Val Gln Leu Gly Ile Pro His Pro Ala Gly Leu Lys 
                245                 250                 255     


Gln Lys Lys Ser Val Thr Val Leu Asp Val Gly Asp Ala Tyr Phe Ser 
            260                 265                 270         


Val Pro Leu Asp Lys Asp Phe Arg Lys Tyr Thr Ala Phe Thr Ile Pro 
        275                 280                 285             


Ser Ile Asn Asn Glu Thr Pro Gly Ile Arg Tyr Gln Tyr Asn Val Leu 
    290                 295                 300                 


Pro Gln Gly Trp Lys Gly Ser Pro Ala Ile Phe Gln Cys Ser Met Thr 
305                 310                 315                 320 


Lys Ile Leu Glu Pro Phe Arg Lys Gln Asn Pro Asp Ile Val Ile Tyr 
                325                 330                 335     


Gln Tyr Met Asp Asp Leu Tyr Val Gly Ser Asp Leu Glu Ile Gly Gln 
            340                 345                 350         


His Arg Thr Lys Ile Glu Glu Leu Arg Gln His Leu Leu Arg Trp Gly 
        355                 360                 365             


Phe Thr Thr Pro Asp Lys Lys His Gln Lys Glu Pro Pro Phe Leu Trp 
    370                 375                 380                 


Met Gly Tyr Glu Leu His Pro Asp Lys Trp Thr Val Gln Pro Ile Val 
385                 390                 395                 400 


Leu Pro Glu Lys Asp Ser Trp Thr Val Asn Asp Ile Gln Lys Leu Val 
                405                 410                 415     


Gly Lys Leu Asn Trp Ala Ser Gln Ile Tyr Ala Gly Ile Lys Val Arg 
            420                 425                 430         


Gln Leu Cys Lys Leu Leu Arg Gly Thr Lys Ala Leu Thr Glu Val Val 
        435                 440                 445             


Pro Leu Thr Glu Glu Ala Glu Leu Glu Leu Ala Glu Asn Arg Glu Ile 
    450                 455                 460                 


Leu Lys Glu Pro Val His Gly Val Tyr Tyr Asp Pro Ser Lys Asp Leu 
465                 470                 475                 480 


Ile Ala Glu Ile Gln Lys Gln Gly Gln Gly Gln Trp Thr Tyr Gln Ile 
                485                 490                 495     


Tyr Gln Glu Pro Phe Lys Asn Leu Lys Thr Gly Lys Tyr Ala Arg Met 
            500                 505                 510         


Lys Gly Ala His Thr Asn Asp Val Lys Gln Leu Thr Glu Ala Val Gln 
        515                 520                 525             


Lys Ile Ala Thr Glu Ser Ile Val Ile Trp Gly Lys Thr Pro Lys Phe 
    530                 535                 540                 


Lys Leu Pro Ile Gln Lys Glu Thr Trp Glu Ala Trp Trp Thr Glu Tyr 
545                 550                 555                 560 


Trp Gln Ala Thr Trp Ile Pro Glu Trp Glu Phe Val Asn Thr Pro Pro 
                565                 570                 575     


Leu Val Lys Leu Trp Tyr Gln Leu Glu Lys Glu Pro Ile Ile Gly Ala 
            580                 585                 590         


Glu Thr Phe Tyr Val Asp Gly Ala Ala Asn Arg Glu Thr Lys Leu Gly 
        595                 600                 605             


Lys Ala Gly Tyr Val Thr Asp Arg Gly Arg Gln Lys Val Val Pro Leu 
    610                 615                 620                 


Thr Asp Thr Thr Asn Gln Lys Thr Glu Leu Gln Ala Ile His Leu Ala 
625                 630                 635                 640 


Leu Gln Asp Ser Gly Leu Glu Val Asn Ile Val Thr Asp Ser Gln Tyr 
                645                 650                 655     


Ala Leu Gly Ile Ile Gln Ala Gln Pro Asp Lys Ser Glu Ser Glu Leu 
            660                 665                 670         


Val Ser Gln Ile Ile Glu Gln Leu Ile Lys Lys Glu Lys Val Tyr Leu 
        675                 680                 685             


Ala Trp Val Pro Ala His Lys Gly Ile Gly Gly Asn Glu Gln Val Asp 
    690                 695                 700                 


Lys Leu Val Ser Ala Gly Ile Arg Lys Val Leu Phe Leu Asp Gly Ile 
705                 710                 715                 720 


Asp Lys Ala Gln Glu Glu His Glu Lys Tyr His Ser Asn Trp Arg Ala 
                725                 730                 735     


Met Ala Ser Asp Phe Asn Leu Pro Pro Val Val Ala Lys Glu Ile Val 
            740                 745                 750         


Ala Ser Cys Asp Lys Cys Gln Leu Lys Gly Glu Ala Met His Gly Gln 
        755                 760                 765             


Val Asp Cys Ser Pro Gly Ile Trp Gln Leu Asp Cys Thr His Leu Glu 
    770                 775                 780                 


Gly Lys Val Ile Leu Val Ala Val His Val Ala Ser Gly Tyr Ile Glu 
785                 790                 795                 800 


Ala Glu Val Ile Pro Ala Glu Thr Gly Gln Glu Thr Ala Tyr Phe Leu 
                805                 810                 815     


Leu Lys Leu Ala Gly Arg Trp Pro Val Lys Thr Val His Thr Asp Asn 
            820                 825                 830         


Gly Ser Asn Phe Thr Ser Thr Thr Val Lys Ala Ala Cys Trp Trp Ala 
        835                 840                 845             


Gly Ile Lys Gln Glu Phe Gly Ile Pro Tyr Asn Pro Gln Ser Gln Gly 
    850                 855                 860                 


Val Ile Glu Ser Met Asn Lys Glu Leu Lys Lys Ile Ile Gly Gln Val 
865                 870                 875                 880 


Arg Asp Gln Ala Glu His Leu Lys Thr Ala Val Gln Met Ala Val Phe 
                885                 890                 895     


Ile His Asn Phe Lys Arg Lys Gly Gly Ile Gly Gly Tyr Ser Ala Gly 
            900                 905                 910         


Glu Arg Ile Val Asp Ile Ile Ala Thr Asp Ile Gln Thr Lys Glu Leu 
        915                 920                 925             


Gln Lys Gln Ile Thr Lys Ile Gln Asn Phe Arg Val Tyr Tyr Arg Asp 
    930                 935                 940                 


Ser Arg Asp Pro Val Trp Lys Gly Pro Ala Lys Leu Leu Trp Lys Gly 
945                 950                 955                 960 


Glu Gly Ala Val Val Ile Gln Asp Asn Ser Asp Ile Lys Val Val Pro 
                965                 970                 975     


Arg Arg Lys Ala Lys Ile Ile Arg Asp Tyr Gly Lys Gln Met Ala Gly 
            980                 985                 990         


Asp Asp Cys Val Ala Ser Arg Gln  Asp Glu Asp 
        995                 1000             


<210>  19
<211>  511
<212>  PRT
<213>  Unknown

<220>
<223>  Lentivirus

<400>  19

Met Lys Cys Leu Leu Tyr Leu Ala Phe Leu Phe Ile Gly Val Asn Cys 
1               5                   10                  15      


Lys Phe Thr Ile Val Phe Pro His Asn Gln Lys Gly Asn Trp Lys Asn 
            20                  25                  30          


Val Pro Ser Asn Tyr His Tyr Cys Pro Ser Ser Ser Asp Leu Asn Trp 
        35                  40                  45              


His Asn Asp Leu Ile Gly Thr Ala Leu Gln Val Lys Met Pro Lys Ser 
    50                  55                  60                  


His Lys Ala Ile Gln Ala Asp Gly Trp Met Cys His Ala Ser Lys Trp 
65                  70                  75                  80  


Val Thr Thr Cys Asp Phe Arg Trp Tyr Gly Pro Lys Tyr Ile Thr His 
                85                  90                  95      


Ser Ile Arg Ser Phe Thr Pro Ser Val Glu Gln Cys Lys Glu Ser Ile 
            100                 105                 110         


Glu Gln Thr Lys Gln Gly Thr Trp Leu Asn Pro Gly Phe Pro Pro Gln 
        115                 120                 125             


Ser Cys Gly Tyr Ala Thr Val Thr Asp Ala Glu Ala Val Ile Val Gln 
    130                 135                 140                 


Val Thr Pro His His Val Leu Val Asp Glu Tyr Thr Gly Glu Trp Val 
145                 150                 155                 160 


Asp Ser Gln Phe Ile Asn Gly Lys Cys Ser Asn Tyr Ile Cys Pro Thr 
                165                 170                 175     


Val His Asn Ser Thr Thr Trp His Ser Asp Tyr Lys Val Lys Gly Leu 
            180                 185                 190         


Cys Asp Ser Asn Leu Ile Ser Met Asp Ile Thr Phe Phe Ser Glu Asp 
        195                 200                 205             


Gly Glu Leu Ser Ser Leu Gly Lys Glu Gly Thr Gly Phe Arg Ser Asn 
    210                 215                 220                 


Tyr Phe Ala Tyr Glu Thr Gly Gly Lys Ala Cys Lys Met Gln Tyr Cys 
225                 230                 235                 240 


Lys His Trp Gly Val Arg Leu Pro Ser Gly Val Trp Phe Glu Met Ala 
                245                 250                 255     


Asp Lys Asp Leu Phe Ala Ala Ala Arg Phe Pro Glu Cys Pro Glu Gly 
            260                 265                 270         


Ser Ser Ile Ser Ala Pro Ser Gln Thr Ser Val Asp Val Ser Leu Ile 
        275                 280                 285             


Gln Asp Val Glu Arg Ile Leu Asp Tyr Ser Leu Cys Gln Glu Thr Trp 
    290                 295                 300                 


Ser Lys Ile Arg Ala Gly Leu Pro Ile Ser Pro Val Asp Leu Ser Tyr 
305                 310                 315                 320 


Leu Ala Pro Lys Asn Pro Gly Thr Gly Pro Ala Phe Thr Ile Ile Asn 
                325                 330                 335     


Gly Thr Leu Lys Tyr Phe Glu Thr Arg Tyr Ile Arg Val Asp Ile Ala 
            340                 345                 350         


Ala Pro Ile Leu Ser Arg Met Val Gly Met Ile Ser Gly Thr Thr Thr 
        355                 360                 365             


Glu Arg Glu Leu Trp Asp Asp Trp Ala Pro Tyr Glu Asp Val Glu Ile 
    370                 375                 380                 


Gly Pro Asn Gly Val Leu Arg Thr Ser Ser Gly Tyr Lys Phe Pro Leu 
385                 390                 395                 400 


Tyr Met Ile Gly His Gly Met Leu Asp Ser Asp Leu His Leu Ser Ser 
                405                 410                 415     


Lys Ala Gln Val Phe Glu His Pro His Ile Gln Asp Ala Ala Ser Gln 
            420                 425                 430         


Leu Pro Asp Asp Glu Ser Leu Phe Phe Gly Asp Thr Gly Leu Ser Lys 
        435                 440                 445             


Asn Pro Ile Glu Leu Val Glu Gly Trp Phe Ser Ser Trp Lys Ser Ser 
    450                 455                 460                 


Ile Ala Ser Phe Phe Phe Ile Ile Gly Leu Ile Ile Gly Leu Phe Leu 
465                 470                 475                 480 


Val Leu Arg Val Gly Ile His Leu Cys Ile Lys Leu Lys His Thr Lys 
                485                 490                 495     


Lys Arg Gln Ile Tyr Thr Asp Ile Glu Met Asn Arg Leu Gly Lys 
            500                 505                 510     


<210>  20
<211>  116
<212>  PRT
<213>  Unknown

<220>
<223>  Lentivirus

<400>  20

Met Ala Gly Arg Ser Gly Asp Ser Asp Glu Asp Leu Leu Lys Ala Val 
1               5                   10                  15      


Arg Leu Ile Lys Phe Leu Tyr Gln Ser Asn Pro Pro Pro Asn Pro Glu 
            20                  25                  30          


Gly Thr Arg Gln Ala Arg Arg Asn Arg Arg Arg Arg Trp Arg Glu Arg 
        35                  40                  45              


Gln Arg Gln Ile His Ser Ile Ser Glu Arg Ile Leu Ser Thr Tyr Leu 
    50                  55                  60                  


Gly Arg Ser Ala Glu Pro Val Pro Leu Gln Leu Pro Pro Leu Glu Arg 
65                  70                  75                  80  


Leu Thr Leu Asp Cys Asn Glu Asp Cys Gly Thr Ser Gly Thr Gln Gly 
                85                  90                  95      


Val Gly Ser Pro Gln Ile Leu Val Glu Ser Pro Thr Ile Leu Glu Ser 
            100                 105                 110         


Gly Ala Lys Glu 
        115     


<210>  21
<211>  578
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Synthetic

<400>  21
cccctctccc tccccccccc ctaacgttac tggccgaagc cgcttggaat aaggccggtg       60

tgcgtttgtc tatatgttat tttccaccat attgccgtct tttggcaatg tgagggcccg      120

gaaacctggc cctgtcttct tgacgagcat tcctaggggt ctttcccctc tcgccaaagg      180

aatgcaaggt ctgttgaatg tcgtgaagga agcagttcct ctggaagctt cttgaagaca      240

aacaacgtct gtagcgaccc tttgcaggca gcggaacccc ccacctggcg acaggtgcct      300

ctgcggccaa aagccacgtg tataagatac acctgcaaag gcggcacaac cccagtgcca      360

cgttgtgagt tggatagttg tggaaagagt caaatggctc tcctcaagcg tattcaacaa      420

ggggctgaag gatgcccaga aggtacccca ttgtatggga tctgatctgg ggcctcggtg      480

cacatgcttt acatgtgttt agtcgaggtt aaaaaaacgt ctaggccccc cgaaccacgg      540

ggacgtggtt ttcctttgaa aaacacgatg ataatatg                              578


<210>  22
<211>  571
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Synthetic

<400>  22
cccccccccc taacgttact ggccgaagcc gcttggaata aggccggtgt gcgtttgtct       60

atatgttatt ttccaccata ttgccgtctt ttggcaatgt gagggcccgg aaacctggcc      120

ctgtcttctt gacgagcatt cctaggggtc tttcccctct cgccaaagga atgcaaggtc      180

tgttgaatgt cgtgaaggaa gcagttcctc tggaagcttc ttgaagacaa acaacgtctg      240

tagcgaccct ttgcaggcag cggaaccccc cacctggcga caggtgcctc tgcggccaaa      300

agccacgtgt ataagataca cctgcaaagg cggcacaacc ccagtgccac gttgtgagtt      360

ggatagttgt ggaaagagtc aaatggctct cctcaagcgt attcaacaag gggctgaagg      420

atgcccagaa ggtaccccat tgtatgggat ctgatctggg gcctcggtgc acatgcttta      480

catgtgttta gtcgaggtta aaaaaacgtc taggcccccc gaaccacggg gacgtggttt      540

tcctttgaaa aacacgatga taatagttat c                                     571


<210>  23
<211>  19
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic

<400>  23

Ala Thr Asn Phe Ser Leu Leu Lys Gln Ala Gly Asp Val Glu Glu Asn 
1               5                   10                  15      


Pro Gly Pro 
            


<210>  24
<211>  18
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic

<400>  24

Glu Gly Arg Gly Ser Leu Leu Thr Cys Gly Asp Val Glu Glu Asn Pro 
1               5                   10                  15      


Gly Pro 
        


<210>  25
<211>  20
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic

<400>  25

Gln Cys Thr Asn Tyr Ala Leu Leu Lys Leu Ala Gly Asp Val Glu Ser 
1               5                   10                  15      


Asn Pro Gly Pro 
            20  


<210>  26
<211>  22
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic

<400>  26

Val Lys Gln Thr Leu Asn Phe Asp Leu Leu Lys Leu Ala Gly Asp Val 
1               5                   10                  15      


Glu Ser Asn Pro Gly Pro 
            20          


<210>  27
<211>  261
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic

<400>  27

Met Ser Arg Leu Asp Lys Ser Lys Val Ile Asn Ser Ala Leu Glu Leu 
1               5                   10                  15      


Leu Asn Glu Val Gly Ile Glu Gly Leu Thr Thr Arg Lys Leu Ala Gln 
            20                  25                  30          


Lys Leu Gly Val Glu Gln Pro Thr Leu Tyr Trp His Val Lys Asn Lys 
        35                  40                  45              


Arg Ala Leu Leu Asp Ala Leu Ala Ile Glu Met Leu Asp Arg His His 
    50                  55                  60                  


Thr His Phe Cys Pro Leu Glu Gly Glu Ser Trp Gln Asp Phe Leu Arg 
65                  70                  75                  80  


Asn Asn Ala Lys Ser Phe Arg Cys Ala Leu Leu Ser His Arg Asp Gly 
                85                  90                  95      


Ala Lys Val His Leu Gly Thr Arg Pro Thr Glu Lys Gln Tyr Glu Thr 
            100                 105                 110         


Leu Glu Asn Gln Leu Ala Phe Leu Cys Gln Gln Gly Phe Ser Leu Glu 
        115                 120                 125             


Asn Ala Leu Tyr Ala Leu Ser Ala Val Gly His Phe Thr Leu Gly Cys 
    130                 135                 140                 


Val Leu Glu Asp Gln Glu His Gln Val Ala Lys Glu Glu Arg Glu Thr 
145                 150                 155                 160 


Pro Thr Thr Asp Ser Met Pro Pro Leu Leu Arg Gln Ala Ile Glu Leu 
                165                 170                 175     


Phe Asp His Gln Gly Ala Glu Pro Ala Phe Leu Phe Gly Leu Glu Leu 
            180                 185                 190         


Ile Ile Cys Gly Leu Glu Lys Gln Leu Lys Cys Glu Ser Gly Ser Pro 
        195                 200                 205             


Lys Lys Lys Arg Lys Val Asp Tyr Lys Asp Asp Asp Asp Lys Pro Ala 
    210                 215                 220                 


Asp Ala Leu Asp Asp Phe Asp Leu Asp Met Leu Pro Ala Asp Ala Leu 
225                 230                 235                 240 


Asp Asp Phe Asp Leu Asp Met Leu Pro Ala Asp Ala Leu Asp Asp Phe 
                245                 250                 255     


Asp Leu Asp Met Leu 
            260     


<210>  28
<211>  335
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic

<400>  28

Met Ser Arg Leu Asp Lys Ser Lys Val Ile Asn Ser Ala Leu Glu Leu 
1               5                   10                  15      


Leu Asn Glu Val Gly Ile Glu Gly Leu Thr Thr Arg Lys Leu Ala Gln 
            20                  25                  30          


Lys Leu Gly Val Glu Gln Pro Thr Leu Tyr Trp His Val Lys Asn Lys 
        35                  40                  45              


Arg Ala Leu Leu Asp Ala Leu Ala Ile Glu Met Leu Asp Arg His His 
    50                  55                  60                  


Thr His Phe Cys Pro Leu Glu Gly Glu Ser Trp Gln Asp Phe Leu Arg 
65                  70                  75                  80  


Asn Asn Ala Lys Ser Phe Arg Cys Ala Leu Leu Ser His Arg Asp Gly 
                85                  90                  95      


Ala Lys Val His Leu Gly Thr Arg Pro Thr Glu Lys Gln Tyr Glu Thr 
            100                 105                 110         


Leu Glu Asn Gln Leu Ala Phe Leu Cys Gln Gln Gly Phe Ser Leu Glu 
        115                 120                 125             


Asn Ala Leu Tyr Ala Leu Ser Ala Val Gly His Phe Thr Leu Gly Cys 
    130                 135                 140                 


Val Leu Glu Asp Gln Glu His Gln Val Ala Lys Glu Glu Arg Glu Thr 
145                 150                 155                 160 


Pro Thr Thr Asp Ser Met Pro Pro Leu Leu Arg Gln Ala Ile Glu Leu 
                165                 170                 175     


Phe Asp His Gln Gly Ala Glu Pro Ala Phe Leu Phe Gly Leu Glu Leu 
            180                 185                 190         


Ile Ile Cys Gly Leu Glu Lys Gln Leu Lys Cys Glu Ser Gly Ser Ala 
        195                 200                 205             


Tyr Ser Arg Ala Arg Thr Lys Asn Asn Tyr Gly Ser Thr Ile Glu Gly 
    210                 215                 220                 


Leu Leu Asp Leu Pro Asp Asp Asp Ala Pro Glu Glu Ala Gly Leu Ala 
225                 230                 235                 240 


Ala Pro Arg Leu Ser Phe Leu Pro Ala Gly His Thr Arg Arg Leu Ser 
                245                 250                 255     


Thr Ala Pro Pro Thr Asp Val Ser Leu Gly Asp Glu Leu His Leu Asp 
            260                 265                 270         


Gly Glu Asp Val Ala Met Ala His Ala Asp Ala Leu Asp Asp Phe Asp 
        275                 280                 285             


Leu Asp Met Leu Gly Asp Gly Asp Ser Pro Gly Pro Gly Phe Thr Pro 
    290                 295                 300                 


His Asp Ser Ala Pro Tyr Gly Ala Leu Asp Met Ala Asp Phe Glu Phe 
305                 310                 315                 320 


Glu Gln Met Phe Thr Asp Ala Leu Gly Ile Asp Glu Tyr Gly Gly 
                325                 330                 335 


