                         SEQUENCE LISTING

<110>  Moraes, Carlos
       Smith, James J.
       Tomberlin, Ginger
       Morris, John
       Shoop, Wendy
 
<120>  ENGINEERED MEGANUCLEASES THAT TARGET HUMAN MITOCHONDRIAL GENOMES

<130>  P89339 1180WO (0139.5)

<150>  US 63/178,263
<151>  2021-04-22

<150>  US 63/318,192
<151>  2022-03-09

<150>  US 63/178,250
<151>  2021-04-22

<150>  US 63/318,191
<151>  2022-03-09

<160>  72    

<170>  PatentIn version 3.5

<210>  1
<211>  22
<212>  DNA
<213>  Homo sapiens

<400>  1
cagggcccgg taatcgcata aa                                                22


<210>  2
<211>  22
<212>  DNA
<213>  Homo sapiens

<400>  2
gtcccgggcc attagcgtat tt                                                22


<210>  3
<211>  354
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthesized

<400>  3

Met Asn Thr Lys Tyr Asn Lys Glu Phe Leu Leu Tyr Leu Ala Gly Phe 
1               5                   10                  15      


Val Asp Ser Asp Gly Ser Ile Phe Ala Arg Ile Glu Pro Thr Gln Ser 
            20                  25                  30          


Ala Lys Phe Lys His Lys Leu Arg Leu Thr Phe Arg Val His Gln Lys 
        35                  40                  45              


Thr Gln Arg Arg Trp Phe Leu Asp Lys Leu Val Asp Glu Ile Gly Val 
    50                  55                  60                  


Gly Tyr Val Tyr Asp Thr Gly Ser Val Ser Asp Tyr Thr Leu Ser Gln 
65                  70                  75                  80  


Ile Lys Pro Leu His Asn Phe Leu Thr Gln Leu Gln Pro Phe Leu Lys 
                85                  90                  95      


Leu Lys Gln Lys Gln Ala Asn Leu Val Leu Lys Ile Ile Glu Gln Leu 
            100                 105                 110         


Pro Ser Ala Lys Glu Ser Pro Asp Lys Phe Leu Glu Val Cys Thr Trp 
        115                 120                 125             


Val Asp Gln Ile Ala Ala Leu Asn Asp Ser Lys Thr Arg Lys Thr Thr 
    130                 135                 140                 


Ser Glu Thr Val Arg Ala Val Leu Asp Ser Leu Pro Gly Ser Val Gly 
145                 150                 155                 160 


Gly Leu Ser Pro Ser Gln Ala Ser Ser Ala Ala Ser Ser Ala Ser Ser 
                165                 170                 175     


Ser Pro Gly Ser Gly Ile Ser Glu Ala Leu Arg Ala Gly Ala Gly Ser 
            180                 185                 190         


Gly Thr Gly Tyr Asn Lys Glu Phe Leu Leu Tyr Leu Ala Gly Phe Val 
        195                 200                 205             


Asp Gly Asp Gly Ser Ile Tyr Ala Cys Ile Leu Pro Asn Gln Gly Ser 
    210                 215                 220                 


Lys Phe Lys His Ala Leu Gln Leu Phe Phe Thr Val Gly Gln Lys Thr 
225                 230                 235                 240 


Cys Arg Arg Trp Phe Leu Asp Lys Leu Val Asp Glu Ile Gly Val Gly 
                245                 250                 255     


Tyr Val His Asp His Gly Thr Ile Ser Gln Tyr Arg Leu Ser Glu Ile 
            260                 265                 270         


Lys Pro Leu His Asn Phe Leu Thr Gln Leu Gln Pro Phe Leu Lys Leu 
        275                 280                 285             


Lys Gln Lys Gln Ala Asn Leu Val Leu Lys Ile Ile Glu Gln Leu Pro 
    290                 295                 300                 


Ser Ala Lys Glu Ser Pro Asp Lys Phe Leu Glu Val Cys Thr Trp Val 
305                 310                 315                 320 


Asp Gln Ile Ala Ala Leu Asn Asp Ser Arg Thr Arg Lys Thr Thr Ser 
                325                 330                 335     


Glu Thr Val Arg Ala Val Leu Asp Ser Leu Ser Glu Lys Lys Lys Ser 
            340                 345                 350         


Ser Pro 
        


<210>  4
<211>  354
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthesized

<400>  4

Met Asn Thr Lys Tyr Asn Lys Glu Phe Leu Leu Tyr Leu Ala Gly Phe 
1               5                   10                  15      


Val Asp Ala Asp Gly Ser Ile Phe Ala Arg Ile Glu Pro Thr Gln Ser 
            20                  25                  30          


Ala Lys Phe Lys His Lys Leu Arg Leu Thr Phe Arg Val His Gln Lys 
        35                  40                  45              


Thr Gln Arg Arg Trp Phe Leu Asp Lys Leu Val Asp Glu Ile Gly Val 
    50                  55                  60                  


Gly Tyr Val Tyr Asp Thr Gly Ser Val Ser Asp Tyr Thr Leu Ser Glu 
65                  70                  75                  80  


Ile Lys Pro Leu His Asn Phe Leu Thr Gln Leu Gln Pro Phe Leu Lys 
                85                  90                  95      


Leu Lys Gln Lys Gln Ala Asn Leu Val Leu Lys Ile Ile Glu Gln Leu 
            100                 105                 110         


Pro Ser Ala Lys Glu Ser Pro Asp Lys Phe Leu Glu Val Cys Thr Trp 
        115                 120                 125             


Val Asp Gln Ile Ala Ala Leu Asn Asp Ser Lys Thr Arg Lys Thr Thr 
    130                 135                 140                 


Ser Glu Thr Val Arg Ala Val Leu Asp Ser Leu Pro Gly Ser Val Gly 
145                 150                 155                 160 


Gly Leu Ser Pro Ser Gln Ala Ser Ser Ala Ala Ser Ser Ala Ser Ser 
                165                 170                 175     


Ser Pro Gly Ser Gly Ile Ser Glu Ala Leu Arg Ala Gly Ala Gly Ser 
            180                 185                 190         


Gly Thr Gly Tyr Asn Lys Glu Phe Leu Leu Tyr Leu Ala Gly Phe Val 
        195                 200                 205             


Asp Gly Asp Gly Ser Ile Tyr Ala Cys Ile Leu Pro Asn Gln Gly Ser 
    210                 215                 220                 


Lys Phe Lys His Ala Leu Gln Leu Phe Phe Thr Val Gly Gln Lys Thr 
225                 230                 235                 240 


Cys Arg Arg Trp Phe Leu Asp Lys Leu Val Asp Glu Ile Gly Val Gly 
                245                 250                 255     


Tyr Val Asn Asp Phe Gly Ser Ile Ser Gln Tyr Arg Leu Ser Glu Ile 
            260                 265                 270         


Lys Pro Leu Tyr Asn Phe Leu Thr Gln Leu Gln Pro Phe Leu Lys Leu 
        275                 280                 285             


Lys Gln Lys Gln Ala Asn Leu Val Leu Lys Ile Ile Glu Gln Leu Pro 
    290                 295                 300                 


Ser Ala Lys Glu Ser Pro Asp Lys Phe Leu Glu Val Cys Thr Trp Val 
305                 310                 315                 320 


Asp Gln Ile Ala Ala Leu Asn Asp Ser Arg Thr Arg Lys Thr Thr Ser 
                325                 330                 335     


Glu Thr Val Arg Ala Val Leu Asp Ser Leu Ser Glu Lys Lys Lys Ser 
            340                 345                 350         


Ser Pro 
        


<210>  5
<211>  354
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthesized

<400>  5

Met Asn Thr Lys Tyr Asn Lys Glu Phe Leu Leu Tyr Leu Ala Gly Phe 
1               5                   10                  15      


Val Asp Ala Asp Gly Ser Ile Phe Ala Arg Ile Glu Pro Thr Gln Ser 
            20                  25                  30          


Ala Lys Phe Lys His Lys Leu Arg Leu Thr Phe Arg Val His Gln Lys 
        35                  40                  45              


Thr Gln Arg Arg Trp Phe Leu Asp Lys Leu Val Asp Glu Ile Gly Val 
    50                  55                  60                  


Gly Tyr Val Tyr Asp Thr Gly Ser Val Ser Asp Tyr Thr Leu Ser Gln 
65                  70                  75                  80  


Ile Lys Pro Leu His Asn Phe Leu Thr Gln Leu Gln Pro Phe Leu Lys 
                85                  90                  95      


Leu Lys Gln Lys Gln Ala Asn Leu Val Leu Lys Ile Ile Glu Gln Leu 
            100                 105                 110         


Pro Ser Ala Lys Glu Ser Pro Asp Lys Phe Leu Glu Val Cys Thr Trp 
        115                 120                 125             


Val Asp Gln Ile Ala Ala Leu Asn Asp Ser Lys Thr Arg Lys Thr Thr 
    130                 135                 140                 


Ser Glu Thr Val Arg Ala Val Leu Asp Ser Leu Pro Gly Ser Val Gly 
145                 150                 155                 160 


Gly Leu Ser Pro Ser Gln Ala Ser Ser Ala Ala Ser Ser Ala Ser Ser 
                165                 170                 175     


Ser Pro Gly Ser Gly Ile Ser Glu Ala Leu Arg Ala Gly Ala Gly Ser 
            180                 185                 190         


Gly Thr Gly Tyr Asn Lys Glu Phe Leu Leu Tyr Leu Ala Gly Phe Val 
        195                 200                 205             


Asp Gly Asp Gly Ser Ile Tyr Ala Cys Ile Leu Pro Asn Gln Gly Ser 
    210                 215                 220                 


Lys Phe Lys His Ala Leu Gln Leu Phe Phe Thr Val Gly Gln Lys Thr 
225                 230                 235                 240 


Cys Arg Arg Trp Phe Leu Asp Lys Leu Val Asp Glu Ile Gly Val Gly 
                245                 250                 255     


Tyr Val His Asp Phe Gly Leu Ile Ser Gln Tyr Arg Leu Ser Glu Ile 
            260                 265                 270         


Lys Pro Leu His Asn Phe Leu Thr Gln Leu Gln Pro Phe Leu Lys Leu 
        275                 280                 285             


Lys Gln Lys Gln Ala Asn Leu Val Leu Lys Ile Ile Glu Gln Leu Pro 
    290                 295                 300                 


Ser Ala Lys Glu Ser Pro Asp Lys Phe Leu Glu Val Cys Thr Trp Val 
305                 310                 315                 320 


Asp Gln Ile Ala Ala Leu Asn Asp Ser Arg Thr Arg Lys Thr Thr Ser 
                325                 330                 335     


Glu Thr Val Arg Ala Val Leu Asp Ser Leu Ser Glu Lys Lys Lys Ser 
            340                 345                 350         


Ser Pro 
        


<210>  6
<211>  354
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthesized

<400>  6

Met Asn Thr Lys Tyr Asn Lys Glu Phe Leu Leu Tyr Leu Ala Gly Phe 
1               5                   10                  15      


Val Asp Ala Asp Gly Ser Ile Phe Ala Arg Ile Glu Pro Thr Gln Ser 
            20                  25                  30          


Ala Lys Phe Lys His Lys Leu Arg Leu Thr Phe Arg Val His Gln Lys 
        35                  40                  45              


Thr Gln Arg Arg Trp Phe Leu Asp Lys Leu Val Asp Glu Ile Gly Val 
    50                  55                  60                  


Gly Tyr Val Tyr Asp Thr Gly Ser Val Ser Asp Tyr Thr Leu Ser Glu 
65                  70                  75                  80  


Ile Lys Pro Leu His Asn Phe Leu Thr Gln Leu Gln Pro Phe Leu Lys 
                85                  90                  95      


Leu Lys Gln Lys Gln Ala Asn Leu Val Leu Lys Ile Ile Glu Gln Leu 
            100                 105                 110         


Pro Ser Ala Lys Glu Ser Pro Asp Lys Phe Leu Glu Val Cys Thr Trp 
        115                 120                 125             


Val Asp Gln Ile Ala Ala Leu Asn Asp Ser Lys Thr Arg Lys Thr Thr 
    130                 135                 140                 


Ser Glu Thr Val Arg Ala Val Leu Asp Ser Leu Pro Gly Ser Val Gly 
145                 150                 155                 160 


Gly Leu Ser Pro Ser Gln Ala Ser Ser Ala Ala Ser Ser Ala Ser Ser 
                165                 170                 175     


Ser Pro Gly Ser Gly Ile Ser Glu Ala Pro Arg Ala Gly Ala Gly Ser 
            180                 185                 190         


Gly Thr Gly Tyr Asn Lys Glu Phe Leu Leu Tyr Leu Ala Gly Phe Val 
        195                 200                 205             


Asp Gly Asp Gly Ser Ile Tyr Ala Cys Ile Leu Pro Asn Gln Gly Ser 
    210                 215                 220                 


Lys Phe Lys His Ala Leu Gln Leu Phe Phe Thr Val Gly Gln Lys Thr 
225                 230                 235                 240 


Cys Arg Arg Trp Phe Leu Asp Lys Leu Val Asp Glu Ile Gly Val Gly 
                245                 250                 255     


Tyr Val His Asp His Gly Leu Ile Ala Gln Tyr Arg Leu Ser Glu Ile 
            260                 265                 270         


Lys Pro Leu His Asn Phe Leu Thr Gln Leu Gln Pro Phe Leu Lys Leu 
        275                 280                 285             


Lys Gln Lys Gln Ala Asn Leu Val Leu Lys Ile Ile Glu Gln Leu Pro 
    290                 295                 300                 


Ser Ala Lys Glu Ser Pro Asp Lys Phe Leu Glu Val Cys Thr Trp Val 
305                 310                 315                 320 


Asp Gln Ile Ala Ala Leu Asn Asp Ser Arg Thr Arg Lys Thr Thr Ser 
                325                 330                 335     


Glu Thr Val Arg Ala Val Leu Asp Ser Leu Ser Glu Lys Lys Lys Ser 
            340                 345                 350         


Ser Pro 
        


<210>  7
<211>  354
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthesized

<400>  7

Met Asn Thr Lys Tyr Asn Lys Glu Phe Leu Leu Tyr Leu Ala Gly Phe 
1               5                   10                  15      


Val Asp Ala Asp Gly Ser Ile Phe Ala Arg Ile Glu Pro Thr Gln Ser 
            20                  25                  30          


Ala Lys Phe Lys His Lys Leu Arg Leu Thr Phe Arg Val His Gln Lys 
        35                  40                  45              


Thr Gln Arg Arg Trp Phe Leu Asp Lys Leu Val Asp Glu Ile Gly Val 
    50                  55                  60                  


Gly Tyr Val Tyr Asp Thr Gly Ser Val Ser Asp Tyr Thr Leu Ser Gln 
65                  70                  75                  80  


Ile Lys Pro Leu His Asn Phe Leu Thr Gln Leu Gln Pro Phe Leu Lys 
                85                  90                  95      


Leu Lys Gln Lys Gln Ala Asn Leu Val Leu Lys Ile Ile Glu Gln Leu 
            100                 105                 110         


Pro Ser Ala Lys Glu Ser Pro Asp Lys Phe Leu Glu Val Cys Thr Trp 
        115                 120                 125             


Val Asp Gln Ile Ala Ala Leu Asn Asp Ser Lys Thr Arg Lys Thr Thr 
    130                 135                 140                 


Ser Glu Thr Val Arg Ala Val Leu Asp Ser Leu Pro Gly Ser Val Gly 
145                 150                 155                 160 


Gly Leu Ser Pro Ser Gln Ala Ser Ser Ala Ala Ser Ser Ala Ser Ser 
                165                 170                 175     


Ser Pro Gly Ser Gly Ile Ser Glu Ala Leu Arg Ala Gly Ala Gly Ser 
            180                 185                 190         


Gly Thr Gly Tyr Asn Lys Glu Phe Leu Leu Tyr Leu Ala Gly Phe Val 
        195                 200                 205             


Asp Gly Asp Gly Ser Ile Tyr Ala Cys Ile Leu Pro Asn Gln Gly Ser 
    210                 215                 220                 


Lys Phe Lys His Ala Leu Gln Leu Phe Phe Thr Val Gly Gln Lys Thr 
225                 230                 235                 240 


Cys Arg Arg Trp Phe Leu Asp Lys Leu Val Asp Glu Ile Gly Val Gly 
                245                 250                 255     


Tyr Val Asn Asp Phe Gly Pro Val Ser Gln Tyr Arg Leu Ser Glu Ile 
            260                 265                 270         


Lys Pro Leu His Asn Phe Leu Thr Gln Leu Gln Pro Phe Leu Lys Leu 
        275                 280                 285             


Lys Gln Lys Gln Ala Asn Leu Val Leu Lys Ile Ile Glu Gln Leu Pro 
    290                 295                 300                 


Ser Ala Lys Glu Ser Pro Asp Lys Phe Leu Glu Val Cys Thr Trp Val 
305                 310                 315                 320 


Asp Gln Ile Ala Ala Leu Asn Asp Ser Arg Thr Arg Lys Thr Thr Ser 
                325                 330                 335     


Glu Thr Val Arg Ala Val Leu Asp Ser Leu Ser Glu Lys Lys Lys Ser 
            340                 345                 350         


Ser Pro 
        


<210>  8
<211>  354
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthesized

<400>  8

Met Asn Thr Lys Tyr Asn Lys Glu Phe Leu Leu Tyr Leu Ala Gly Phe 
1               5                   10                  15      


Val Asp Ala Asp Gly Ser Ile Phe Ala Arg Ile Glu Pro Thr Gln Ser 
            20                  25                  30          


Ala Lys Phe Lys His Lys Leu Arg Leu Thr Phe Arg Val Trp Gln Lys 
        35                  40                  45              


Thr Gln Arg Arg Trp Phe Leu Asp Lys Leu Val Asp Glu Ile Gly Val 
    50                  55                  60                  


Gly Tyr Val Tyr Asp Glu Gly Ser Val Ser Ser Tyr Thr Leu Ser Glu 
65                  70                  75                  80  


Ile Lys Pro Leu His Asn Phe Leu Thr Gln Leu Gln Pro Phe Leu Lys 
                85                  90                  95      


Leu Lys Gln Lys Gln Ala Asn Leu Val Leu Lys Ile Ile Glu Gln Leu 
            100                 105                 110         


Pro Ser Ala Lys Glu Ser Pro Asp Lys Phe Leu Glu Val Cys Thr Trp 
        115                 120                 125             


Val Asp Gln Ile Ala Ala Leu Asn Asp Ser Lys Thr Arg Lys Thr Thr 
    130                 135                 140                 


Ser Glu Thr Val Arg Ala Val Leu Asp Ser Leu Pro Gly Ser Val Gly 
145                 150                 155                 160 


Gly Leu Ser Pro Ser Gln Ala Ser Ser Ala Ala Ser Ser Ala Ser Ser 
                165                 170                 175     


Ser Pro Gly Ser Gly Ile Ser Glu Ala Leu Arg Ala Gly Ala Gly Ser 
            180                 185                 190         


Gly Thr Gly Tyr Asn Lys Glu Phe Leu Leu Tyr Leu Ala Gly Phe Val 
        195                 200                 205             


Asp Gly Asp Gly Ser Ile Tyr Ala Cys Ile Leu Pro Asn Gln Gly Ser 
    210                 215                 220                 


Lys Phe Lys His Ala Leu Gln Leu Phe Phe Thr Val Gly Gln Lys Thr 
225                 230                 235                 240 


Cys Arg Arg Trp Phe Leu Asp Lys Leu Val Asp Glu Ile Gly Val Gly 
                245                 250                 255     


Tyr Val Gln Asp His Gly Arg Ile Ser Gln Tyr Arg Leu Ser Glu Ile 
            260                 265                 270         


Lys Pro Leu His Asn Phe Leu Thr Gln Leu Gln Pro Phe Leu Lys Leu 
        275                 280                 285             


Lys Gln Lys Gln Ala Asn Leu Val Leu Lys Ile Ile Glu Gln Leu Pro 
    290                 295                 300                 


Ser Ala Lys Glu Ser Pro Asp Lys Phe Leu Glu Val Cys Thr Trp Val 
305                 310                 315                 320 


Asp Gln Ile Ala Ala Leu Asn Asp Ser Arg Thr Arg Lys Thr Thr Ser 
                325                 330                 335     


Glu Thr Val Arg Ala Val Leu Asp Ser Leu Ser Glu Lys Lys Lys Ser 
            340                 345                 350         


Ser Pro 
        


<210>  9
<211>  354
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthesized

<400>  9

Met Asn Thr Lys Tyr Asn Lys Glu Phe Leu Leu Tyr Leu Ala Gly Phe 
1               5                   10                  15      


Val Asp Ser Asp Gly Ser Ile Phe Ala Arg Ile Glu Pro Thr Gln Ser 
            20                  25                  30          


Ala Lys Phe Lys His Lys Leu Arg Leu Thr Phe Arg Val His Gln Lys 
        35                  40                  45              


Thr Gln Arg Arg Trp Phe Leu Asp Lys Leu Val Asp Glu Ile Gly Val 
    50                  55                  60                  


Gly Tyr Val Tyr Asp Thr Gly Ser Val Ser Asp Tyr Thr Leu Ser Gln 
65                  70                  75                  80  


Ile Lys Pro Leu His Asn Phe Leu Thr Gln Leu Gln Pro Phe Leu Lys 
                85                  90                  95      


Leu Lys Gln Lys Gln Ala Asn Leu Val Leu Lys Ile Ile Glu Gln Leu 
            100                 105                 110         


Pro Ser Ala Lys Glu Ser Pro Asp Lys Phe Leu Glu Val Cys Thr Trp 
        115                 120                 125             


Val Asp Gln Ile Ala Ala Leu Asn Asp Ser Lys Thr Arg Lys Thr Thr 
    130                 135                 140                 


Ser Glu Thr Val Arg Ala Val Leu Asp Ser Leu Pro Gly Ser Val Gly 
145                 150                 155                 160 


Gly Leu Ser Pro Ser Gln Ala Ser Ser Ala Ala Ser Ser Ala Ser Ser 
                165                 170                 175     


Ser Pro Gly Ser Gly Ile Ser Glu Ala Leu Arg Ala Gly Ala Gly Ser 
            180                 185                 190         


Gly Thr Gly Tyr Asn Lys Glu Phe Leu Leu Tyr Leu Ala Gly Phe Val 
        195                 200                 205             


Asp Gly Asp Gly Ser Ile Tyr Ala Cys Ile Leu Pro Asn Gln Gly Ser 
    210                 215                 220                 


Lys Phe Lys His Ala Leu Gln Leu Phe Phe Thr Val Gly Gln Lys Thr 
225                 230                 235                 240 


Cys Arg Arg Trp Phe Leu Asp Lys Leu Val Asp Glu Ile Gly Val Gly 
                245                 250                 255     


Tyr Val Gln Asp His Gly Thr Ile Ser Gln Tyr Arg Leu Ser Glu Ile 
            260                 265                 270         


Lys Pro Leu His Asn Phe Leu Thr Gln Leu Gln Pro Phe Leu Lys Leu 
        275                 280                 285             


Lys Gln Lys Gln Ala Asn Leu Val Leu Lys Ile Ile Glu Gln Leu Pro 
    290                 295                 300                 


Ser Ala Lys Glu Ser Pro Asp Lys Phe Leu Glu Val Cys Thr Trp Val 
305                 310                 315                 320 


Asp Gln Ile Ala Ala Leu Asn Asp Ser Arg Thr Arg Lys Thr Thr Ser 
                325                 330                 335     


Glu Thr Val Arg Ala Val Leu Asp Ser Leu Ser Glu Lys Lys Lys Ser 
            340                 345                 350         


Ser Pro 
        


<210>  10
<211>  354
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthesized

<400>  10

Met Asn Thr Lys Tyr Asn Lys Glu Phe Leu Leu Tyr Leu Ala Gly Phe 
1               5                   10                  15      


Val Asp Ser Asp Gly Ser Ile Phe Ala Arg Ile Glu Pro Thr Gln Ser 
            20                  25                  30          


Ala Lys Phe Lys His Lys Leu Arg Leu Thr Phe Arg Val Trp Gln Lys 
        35                  40                  45              


Thr Gln Arg Arg Trp Phe Leu Asp Lys Leu Val Asp Glu Ile Gly Val 
    50                  55                  60                  


Gly Tyr Val Tyr Asp Glu Gly Ser Val Ser Ser Tyr Thr Leu Ser Glu 
65                  70                  75                  80  


Ile Lys Pro Leu His Asn Phe Leu Thr Gln Leu Gln Pro Phe Leu Lys 
                85                  90                  95      


Leu Lys Gln Lys Gln Ala Asn Leu Val Leu Lys Ile Ile Glu Gln Leu 
            100                 105                 110         


Pro Ser Ala Lys Glu Ser Pro Asp Lys Phe Leu Glu Val Cys Thr Trp 
        115                 120                 125             


Val Asp Gln Ile Ala Ala Leu Asn Asp Ser Lys Thr Arg Lys Thr Thr 
    130                 135                 140                 


Ser Glu Thr Val Arg Ala Val Leu Asp Ser Leu Pro Gly Ser Val Gly 
145                 150                 155                 160 


Gly Leu Ser Pro Ser Gln Ala Ser Ser Ala Ala Ser Ser Ala Ser Ser 
                165                 170                 175     


Ser Pro Gly Ser Gly Ile Ser Glu Ala Leu Arg Ala Gly Ala Gly Ser 
            180                 185                 190         


Gly Thr Gly Tyr Asn Lys Glu Phe Leu Leu Tyr Leu Ala Gly Phe Val 
        195                 200                 205             


Asp Gly Asp Gly Ser Ile Tyr Ala Cys Ile Leu Pro Asn Gln Gly Ser 
    210                 215                 220                 


Lys Phe Lys His Ala Leu Gln Leu Phe Phe Thr Val Gly Gln Lys Thr 
225                 230                 235                 240 


Cys Arg Arg Trp Phe Leu Asp Lys Leu Val Asp Glu Ile Gly Val Gly 
                245                 250                 255     


Tyr Val Gln Asp His Gly Arg Ile Ser Gln Tyr Arg Leu Ser Glu Ile 
            260                 265                 270         


Lys Pro Leu His Asn Phe Leu Thr Gln Leu Gln Pro Phe Leu Lys Leu 
        275                 280                 285             


Lys Gln Lys Gln Ala Asn Leu Val Leu Lys Ile Ile Glu Gln Leu Pro 
    290                 295                 300                 


Ser Ala Lys Glu Ser Pro Asp Lys Phe Leu Glu Val Cys Thr Trp Val 
305                 310                 315                 320 


Asp Gln Ile Ala Ala Leu Asn Asp Ser Arg Thr Arg Lys Thr Thr Ser 
                325                 330                 335     


Glu Thr Val Arg Ala Val Leu Asp Ser Leu Ser Glu Lys Lys Lys Ser 
            340                 345                 350         


Ser Pro 
        


<210>  11
<211>  354
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthesized

<400>  11

Met Asn Thr Lys Tyr Asn Lys Glu Phe Leu Leu Tyr Leu Ala Gly Phe 
1               5                   10                  15      


Val Asp Ser Asp Gly Ser Ile Phe Ala Arg Ile Glu Pro Thr Gln Ser 
            20                  25                  30          


Ala Lys Phe Lys His Lys Leu Arg Leu Thr Phe Arg Val His Gln Lys 
        35                  40                  45              


Thr Gln Arg Arg Trp Phe Leu Asp Lys Leu Val Asp Glu Ile Gly Val 
    50                  55                  60                  


Gly Tyr Val Tyr Asp Thr Gly Ser Val Ser Asp Tyr Thr Leu Ser Gln 
65                  70                  75                  80  


Ile Lys Pro Leu His Asn Phe Leu Thr Gln Leu Gln Pro Phe Leu Lys 
                85                  90                  95      


Leu Lys Gln Lys Gln Ala Asn Leu Val Leu Lys Ile Ile Glu Gln Leu 
            100                 105                 110         


Pro Ser Ala Lys Glu Ser Pro Asp Lys Phe Leu Glu Val Cys Thr Trp 
        115                 120                 125             


Val Asp Gln Ile Ala Ala Leu Asn Asp Ser Lys Thr Arg Lys Thr Thr 
    130                 135                 140                 


Ser Glu Thr Val Arg Ala Val Leu Asp Ser Leu Pro Gly Ser Val Gly 
145                 150                 155                 160 


Gly Leu Ser Pro Ser Gln Ala Ser Ser Ala Ala Ser Ser Ala Ser Ser 
                165                 170                 175     


Ser Pro Gly Ser Gly Ile Ser Glu Ala Leu Arg Ala Gly Ala Gly Ser 
            180                 185                 190         


Gly Thr Gly Tyr Asn Lys Glu Phe Leu Leu Tyr Leu Ala Gly Phe Val 
        195                 200                 205             


Asp Gly Asp Gly Ser Ile Tyr Ala Cys Ile Leu Pro Asn Gln Gly Ser 
    210                 215                 220                 


Lys Phe Lys His Ala Leu Gln Leu Phe Phe Thr Val Gly Gln Lys Thr 
225                 230                 235                 240 


Cys Arg Arg Trp Phe Leu Asp Lys Leu Val Asp Glu Ile Gly Val Gly 
                245                 250                 255     


Tyr Val His Asp His Gly Arg Ile Ser Gln Tyr Arg Leu Ser Glu Ile 
            260                 265                 270         


Lys Pro Leu His Asn Phe Leu Thr Gln Leu Gln Pro Phe Leu Lys Leu 
        275                 280                 285             


Lys Gln Lys Gln Ala Asn Leu Val Leu Lys Ile Ile Glu Gln Leu Pro 
    290                 295                 300                 


Ser Ala Lys Glu Ser Pro Asp Lys Phe Leu Glu Val Cys Thr Trp Val 
305                 310                 315                 320 


Asp Gln Ile Ala Ala Leu Asn Asp Ser Arg Thr Arg Lys Thr Thr Ser 
                325                 330                 335     


Glu Thr Val Arg Ala Val Leu Asp Ser Leu Ser Glu Lys Lys Lys Ser 
            340                 345                 350         


Ser Pro 
        


<210>  12
<211>  354
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthesized

<400>  12

Met Asn Thr Lys Tyr Asn Lys Glu Phe Leu Leu Tyr Leu Ala Gly Phe 
1               5                   10                  15      


Val Asp Ser Asp Gly Ser Ile Phe Ala Arg Ile Glu Pro Thr Gln Ser 
            20                  25                  30          


Ala Lys Phe Lys His Lys Leu Arg Leu Thr Phe Arg Val Trp Gln Lys 
        35                  40                  45              


Thr Gln Arg Arg Trp Phe Leu Asp Lys Leu Val Asp Glu Ile Gly Val 
    50                  55                  60                  


Gly Tyr Val Tyr Asp Thr Gly Ser Val Ser Asp Tyr Thr Leu Ser Gln 
65                  70                  75                  80  


Ile Lys Pro Leu His Asn Phe Leu Thr Gln Leu Gln Pro Phe Leu Lys 
                85                  90                  95      


Leu Lys Gln Lys Gln Ala Asn Leu Val Leu Lys Ile Ile Glu Gln Leu 
            100                 105                 110         


Pro Ser Ala Lys Glu Ser Pro Asp Lys Phe Leu Glu Val Cys Thr Trp 
        115                 120                 125             


Val Asp Gln Ile Ala Ala Leu Asn Asp Ser Lys Thr Arg Lys Thr Thr 
    130                 135                 140                 


Ser Glu Thr Val Arg Ala Val Leu Asp Ser Leu Pro Gly Ser Val Gly 
145                 150                 155                 160 


Gly Leu Ser Pro Ser Gln Ala Ser Ser Ala Ala Ser Ser Ala Ser Ser 
                165                 170                 175     


Ser Pro Gly Ser Gly Ile Ser Glu Ala Leu Arg Ala Gly Ala Gly Ser 
            180                 185                 190         


Gly Thr Gly Tyr Asn Lys Glu Phe Leu Leu Tyr Leu Ala Gly Phe Val 
        195                 200                 205             


Asp Gly Asp Gly Ser Ile Tyr Ala Cys Ile Leu Pro Asn Gln Gly Ser 
    210                 215                 220                 


Lys Phe Lys His Ala Leu Gln Leu Phe Phe Thr Val Gly Gln Lys Thr 
225                 230                 235                 240 


Cys Arg Arg Trp Phe Leu Asp Lys Leu Val Asp Glu Ile Gly Val Gly 
                245                 250                 255     


Tyr Val His Asp His Gly Thr Ile Ser Gln Tyr Arg Leu Ser Glu Ile 
            260                 265                 270         


Lys Pro Leu His Asn Phe Leu Thr Gln Leu Gln Pro Phe Leu Lys Leu 
        275                 280                 285             


Lys Gln Lys Gln Ala Asn Leu Val Leu Lys Ile Ile Glu Gln Leu Pro 
    290                 295                 300                 


Ser Ala Lys Glu Ser Pro Asp Lys Phe Leu Glu Val Cys Thr Trp Val 
305                 310                 315                 320 


Asp Gln Ile Ala Ala Leu Asn Asp Ser Arg Thr Arg Lys Thr Thr Ser 
                325                 330                 335     


Glu Thr Val Arg Ala Val Leu Asp Ser Leu Ser Glu Lys Lys Lys Ser 
            340                 345                 350         


Ser Pro 
        


<210>  13
<211>  147
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthesized

<400>  13

Lys Glu Phe Leu Leu Tyr Leu Ala Gly Phe Val Asp Ser Asp Gly Ser 
1               5                   10                  15      


Ile Phe Ala Arg Ile Glu Pro Thr Gln Ser Ala Lys Phe Lys His Lys 
            20                  25                  30          


Leu Arg Leu Thr Phe Arg Val His Gln Lys Thr Gln Arg Arg Trp Phe 
        35                  40                  45              


Leu Asp Lys Leu Val Asp Glu Ile Gly Val Gly Tyr Val Tyr Asp Thr 
    50                  55                  60                  


Gly Ser Val Ser Asp Tyr Thr Leu Ser Gln Ile Lys Pro Leu His Asn 
65                  70                  75                  80  


Phe Leu Thr Gln Leu Gln Pro Phe Leu Lys Leu Lys Gln Lys Gln Ala 
                85                  90                  95      


Asn Leu Val Leu Lys Ile Ile Glu Gln Leu Pro Ser Ala Lys Glu Ser 
            100                 105                 110         


Pro Asp Lys Phe Leu Glu Val Cys Thr Trp Val Asp Gln Ile Ala Ala 
        115                 120                 125             


Leu Asn Asp Ser Lys Thr Arg Lys Thr Thr Ser Glu Thr Val Arg Ala 
    130                 135                 140                 


Val Leu Asp 
145         


<210>  14
<211>  147
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthesized

<400>  14

Lys Glu Phe Leu Leu Tyr Leu Ala Gly Phe Val Asp Ala Asp Gly Ser 
1               5                   10                  15      


Ile Phe Ala Arg Ile Glu Pro Thr Gln Ser Ala Lys Phe Lys His Lys 
            20                  25                  30          


Leu Arg Leu Thr Phe Arg Val His Gln Lys Thr Gln Arg Arg Trp Phe 
        35                  40                  45              


Leu Asp Lys Leu Val Asp Glu Ile Gly Val Gly Tyr Val Tyr Asp Thr 
    50                  55                  60                  


Gly Ser Val Ser Asp Tyr Thr Leu Ser Glu Ile Lys Pro Leu His Asn 
65                  70                  75                  80  


Phe Leu Thr Gln Leu Gln Pro Phe Leu Lys Leu Lys Gln Lys Gln Ala 
                85                  90                  95      


Asn Leu Val Leu Lys Ile Ile Glu Gln Leu Pro Ser Ala Lys Glu Ser 
            100                 105                 110         


Pro Asp Lys Phe Leu Glu Val Cys Thr Trp Val Asp Gln Ile Ala Ala 
        115                 120                 125             


Leu Asn Asp Ser Lys Thr Arg Lys Thr Thr Ser Glu Thr Val Arg Ala 
    130                 135                 140                 


Val Leu Asp 
145         


<210>  15
<211>  147
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthesized

<400>  15

Lys Glu Phe Leu Leu Tyr Leu Ala Gly Phe Val Asp Ala Asp Gly Ser 
1               5                   10                  15      


Ile Phe Ala Arg Ile Glu Pro Thr Gln Ser Ala Lys Phe Lys His Lys 
            20                  25                  30          


Leu Arg Leu Thr Phe Arg Val His Gln Lys Thr Gln Arg Arg Trp Phe 
        35                  40                  45              


Leu Asp Lys Leu Val Asp Glu Ile Gly Val Gly Tyr Val Tyr Asp Thr 
    50                  55                  60                  


Gly Ser Val Ser Asp Tyr Thr Leu Ser Gln Ile Lys Pro Leu His Asn 
65                  70                  75                  80  


Phe Leu Thr Gln Leu Gln Pro Phe Leu Lys Leu Lys Gln Lys Gln Ala 
                85                  90                  95      


Asn Leu Val Leu Lys Ile Ile Glu Gln Leu Pro Ser Ala Lys Glu Ser 
            100                 105                 110         


Pro Asp Lys Phe Leu Glu Val Cys Thr Trp Val Asp Gln Ile Ala Ala 
        115                 120                 125             


Leu Asn Asp Ser Lys Thr Arg Lys Thr Thr Ser Glu Thr Val Arg Ala 
    130                 135                 140                 


Val Leu Asp 
145         


<210>  16
<211>  147
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthesized

<400>  16

Lys Glu Phe Leu Leu Tyr Leu Ala Gly Phe Val Asp Ala Asp Gly Ser 
1               5                   10                  15      


Ile Phe Ala Arg Ile Glu Pro Thr Gln Ser Ala Lys Phe Lys His Lys 
            20                  25                  30          


Leu Arg Leu Thr Phe Arg Val His Gln Lys Thr Gln Arg Arg Trp Phe 
        35                  40                  45              


Leu Asp Lys Leu Val Asp Glu Ile Gly Val Gly Tyr Val Tyr Asp Thr 
    50                  55                  60                  


Gly Ser Val Ser Asp Tyr Thr Leu Ser Glu Ile Lys Pro Leu His Asn 
65                  70                  75                  80  


Phe Leu Thr Gln Leu Gln Pro Phe Leu Lys Leu Lys Gln Lys Gln Ala 
                85                  90                  95      


Asn Leu Val Leu Lys Ile Ile Glu Gln Leu Pro Ser Ala Lys Glu Ser 
            100                 105                 110         


Pro Asp Lys Phe Leu Glu Val Cys Thr Trp Val Asp Gln Ile Ala Ala 
        115                 120                 125             


Leu Asn Asp Ser Lys Thr Arg Lys Thr Thr Ser Glu Thr Val Arg Ala 
    130                 135                 140                 


Val Leu Asp 
145         


<210>  17
<211>  147
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthesized

<400>  17

Lys Glu Phe Leu Leu Tyr Leu Ala Gly Phe Val Asp Ala Asp Gly Ser 
1               5                   10                  15      


Ile Phe Ala Arg Ile Glu Pro Thr Gln Ser Ala Lys Phe Lys His Lys 
            20                  25                  30          


Leu Arg Leu Thr Phe Arg Val His Gln Lys Thr Gln Arg Arg Trp Phe 
        35                  40                  45              


Leu Asp Lys Leu Val Asp Glu Ile Gly Val Gly Tyr Val Tyr Asp Thr 
    50                  55                  60                  


Gly Ser Val Ser Asp Tyr Thr Leu Ser Gln Ile Lys Pro Leu His Asn 
65                  70                  75                  80  


Phe Leu Thr Gln Leu Gln Pro Phe Leu Lys Leu Lys Gln Lys Gln Ala 
                85                  90                  95      


Asn Leu Val Leu Lys Ile Ile Glu Gln Leu Pro Ser Ala Lys Glu Ser 
            100                 105                 110         


Pro Asp Lys Phe Leu Glu Val Cys Thr Trp Val Asp Gln Ile Ala Ala 
        115                 120                 125             


Leu Asn Asp Ser Lys Thr Arg Lys Thr Thr Ser Glu Thr Val Arg Ala 
    130                 135                 140                 


Val Leu Asp 
145         


<210>  18
<211>  147
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthesized

<400>  18

Lys Glu Phe Leu Leu Tyr Leu Ala Gly Phe Val Asp Ala Asp Gly Ser 
1               5                   10                  15      


Ile Phe Ala Arg Ile Glu Pro Thr Gln Ser Ala Lys Phe Lys His Lys 
            20                  25                  30          


Leu Arg Leu Thr Phe Arg Val Trp Gln Lys Thr Gln Arg Arg Trp Phe 
        35                  40                  45              


Leu Asp Lys Leu Val Asp Glu Ile Gly Val Gly Tyr Val Tyr Asp Glu 
    50                  55                  60                  


Gly Ser Val Ser Ser Tyr Thr Leu Ser Glu Ile Lys Pro Leu His Asn 
65                  70                  75                  80  


Phe Leu Thr Gln Leu Gln Pro Phe Leu Lys Leu Lys Gln Lys Gln Ala 
                85                  90                  95      


Asn Leu Val Leu Lys Ile Ile Glu Gln Leu Pro Ser Ala Lys Glu Ser 
            100                 105                 110         


Pro Asp Lys Phe Leu Glu Val Cys Thr Trp Val Asp Gln Ile Ala Ala 
        115                 120                 125             


Leu Asn Asp Ser Lys Thr Arg Lys Thr Thr Ser Glu Thr Val Arg Ala 
    130                 135                 140                 


Val Leu Asp 
145         


<210>  19
<211>  147
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthesized

<400>  19

Lys Glu Phe Leu Leu Tyr Leu Ala Gly Phe Val Asp Ser Asp Gly Ser 
1               5                   10                  15      


Ile Phe Ala Arg Ile Glu Pro Thr Gln Ser Ala Lys Phe Lys His Lys 
            20                  25                  30          


Leu Arg Leu Thr Phe Arg Val His Gln Lys Thr Gln Arg Arg Trp Phe 
        35                  40                  45              


Leu Asp Lys Leu Val Asp Glu Ile Gly Val Gly Tyr Val Tyr Asp Thr 
    50                  55                  60                  


Gly Ser Val Ser Asp Tyr Thr Leu Ser Gln Ile Lys Pro Leu His Asn 
65                  70                  75                  80  


Phe Leu Thr Gln Leu Gln Pro Phe Leu Lys Leu Lys Gln Lys Gln Ala 
                85                  90                  95      


Asn Leu Val Leu Lys Ile Ile Glu Gln Leu Pro Ser Ala Lys Glu Ser 
            100                 105                 110         


Pro Asp Lys Phe Leu Glu Val Cys Thr Trp Val Asp Gln Ile Ala Ala 
        115                 120                 125             


Leu Asn Asp Ser Lys Thr Arg Lys Thr Thr Ser Glu Thr Val Arg Ala 
    130                 135                 140                 


Val Leu Asp 
145         


<210>  20
<211>  147
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthesized

<400>  20

Lys Glu Phe Leu Leu Tyr Leu Ala Gly Phe Val Asp Ser Asp Gly Ser 
1               5                   10                  15      


Ile Phe Ala Arg Ile Glu Pro Thr Gln Ser Ala Lys Phe Lys His Lys 
            20                  25                  30          


Leu Arg Leu Thr Phe Arg Val Trp Gln Lys Thr Gln Arg Arg Trp Phe 
        35                  40                  45              


Leu Asp Lys Leu Val Asp Glu Ile Gly Val Gly Tyr Val Tyr Asp Glu 
    50                  55                  60                  


Gly Ser Val Ser Ser Tyr Thr Leu Ser Glu Ile Lys Pro Leu His Asn 
65                  70                  75                  80  


Phe Leu Thr Gln Leu Gln Pro Phe Leu Lys Leu Lys Gln Lys Gln Ala 
                85                  90                  95      


Asn Leu Val Leu Lys Ile Ile Glu Gln Leu Pro Ser Ala Lys Glu Ser 
            100                 105                 110         


Pro Asp Lys Phe Leu Glu Val Cys Thr Trp Val Asp Gln Ile Ala Ala 
        115                 120                 125             


Leu Asn Asp Ser Lys Thr Arg Lys Thr Thr Ser Glu Thr Val Arg Ala 
    130                 135                 140                 


Val Leu Asp 
145         


<210>  21
<211>  147
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthesized

<400>  21

Lys Glu Phe Leu Leu Tyr Leu Ala Gly Phe Val Asp Ser Asp Gly Ser 
1               5                   10                  15      


Ile Phe Ala Arg Ile Glu Pro Thr Gln Ser Ala Lys Phe Lys His Lys 
            20                  25                  30          


Leu Arg Leu Thr Phe Arg Val His Gln Lys Thr Gln Arg Arg Trp Phe 
        35                  40                  45              


Leu Asp Lys Leu Val Asp Glu Ile Gly Val Gly Tyr Val Tyr Asp Thr 
    50                  55                  60                  


Gly Ser Val Ser Asp Tyr Thr Leu Ser Gln Ile Lys Pro Leu His Asn 
65                  70                  75                  80  


Phe Leu Thr Gln Leu Gln Pro Phe Leu Lys Leu Lys Gln Lys Gln Ala 
                85                  90                  95      


Asn Leu Val Leu Lys Ile Ile Glu Gln Leu Pro Ser Ala Lys Glu Ser 
            100                 105                 110         


Pro Asp Lys Phe Leu Glu Val Cys Thr Trp Val Asp Gln Ile Ala Ala 
        115                 120                 125             


Leu Asn Asp Ser Lys Thr Arg Lys Thr Thr Ser Glu Thr Val Arg Ala 
    130                 135                 140                 


Val Leu Asp 
145         


<210>  22
<211>  147
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthesized

<400>  22

Lys Glu Phe Leu Leu Tyr Leu Ala Gly Phe Val Asp Ser Asp Gly Ser 
1               5                   10                  15      


Ile Phe Ala Arg Ile Glu Pro Thr Gln Ser Ala Lys Phe Lys His Lys 
            20                  25                  30          


Leu Arg Leu Thr Phe Arg Val Trp Gln Lys Thr Gln Arg Arg Trp Phe 
        35                  40                  45              


Leu Asp Lys Leu Val Asp Glu Ile Gly Val Gly Tyr Val Tyr Asp Thr 
    50                  55                  60                  


Gly Ser Val Ser Asp Tyr Thr Leu Ser Gln Ile Lys Pro Leu His Asn 
65                  70                  75                  80  


Phe Leu Thr Gln Leu Gln Pro Phe Leu Lys Leu Lys Gln Lys Gln Ala 
                85                  90                  95      


Asn Leu Val Leu Lys Ile Ile Glu Gln Leu Pro Ser Ala Lys Glu Ser 
            100                 105                 110         


Pro Asp Lys Phe Leu Glu Val Cys Thr Trp Val Asp Gln Ile Ala Ala 
        115                 120                 125             


Leu Asn Asp Ser Lys Thr Arg Lys Thr Thr Ser Glu Thr Val Arg Ala 
    130                 135                 140                 


Val Leu Asp 
145         


<210>  23
<211>  147
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthesized

<400>  23

Lys Glu Phe Leu Leu Tyr Leu Ala Gly Phe Val Asp Gly Asp Gly Ser 
1               5                   10                  15      


Ile Tyr Ala Cys Ile Leu Pro Asn Gln Gly Ser Lys Phe Lys His Ala 
            20                  25                  30          


Leu Gln Leu Phe Phe Thr Val Gly Gln Lys Thr Cys Arg Arg Trp Phe 
        35                  40                  45              


Leu Asp Lys Leu Val Asp Glu Ile Gly Val Gly Tyr Val His Asp His 
    50                  55                  60                  


Gly Thr Ile Ser Gln Tyr Arg Leu Ser Glu Ile Lys Pro Leu His Asn 
65                  70                  75                  80  


Phe Leu Thr Gln Leu Gln Pro Phe Leu Lys Leu Lys Gln Lys Gln Ala 
                85                  90                  95      


Asn Leu Val Leu Lys Ile Ile Glu Gln Leu Pro Ser Ala Lys Glu Ser 
            100                 105                 110         


Pro Asp Lys Phe Leu Glu Val Cys Thr Trp Val Asp Gln Ile Ala Ala 
        115                 120                 125             


Leu Asn Asp Ser Arg Thr Arg Lys Thr Thr Ser Glu Thr Val Arg Ala 
    130                 135                 140                 


Val Leu Asp 
145         


<210>  24
<211>  147
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthesized

<400>  24

Lys Glu Phe Leu Leu Tyr Leu Ala Gly Phe Val Asp Gly Asp Gly Ser 
1               5                   10                  15      


Ile Tyr Ala Cys Ile Leu Pro Asn Gln Gly Ser Lys Phe Lys His Ala 
            20                  25                  30          


Leu Gln Leu Phe Phe Thr Val Gly Gln Lys Thr Cys Arg Arg Trp Phe 
        35                  40                  45              


Leu Asp Lys Leu Val Asp Glu Ile Gly Val Gly Tyr Val Asn Asp Phe 
    50                  55                  60                  


Gly Ser Ile Ser Gln Tyr Arg Leu Ser Glu Ile Lys Pro Leu Tyr Asn 
65                  70                  75                  80  


Phe Leu Thr Gln Leu Gln Pro Phe Leu Lys Leu Lys Gln Lys Gln Ala 
                85                  90                  95      


Asn Leu Val Leu Lys Ile Ile Glu Gln Leu Pro Ser Ala Lys Glu Ser 
            100                 105                 110         


Pro Asp Lys Phe Leu Glu Val Cys Thr Trp Val Asp Gln Ile Ala Ala 
        115                 120                 125             


Leu Asn Asp Ser Arg Thr Arg Lys Thr Thr Ser Glu Thr Val Arg Ala 
    130                 135                 140                 


Val Leu Asp 
145         


<210>  25
<211>  147
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthesized

<400>  25

Lys Glu Phe Leu Leu Tyr Leu Ala Gly Phe Val Asp Gly Asp Gly Ser 
1               5                   10                  15      


Ile Tyr Ala Cys Ile Leu Pro Asn Gln Gly Ser Lys Phe Lys His Ala 
            20                  25                  30          


Leu Gln Leu Phe Phe Thr Val Gly Gln Lys Thr Cys Arg Arg Trp Phe 
        35                  40                  45              


Leu Asp Lys Leu Val Asp Glu Ile Gly Val Gly Tyr Val His Asp Phe 
    50                  55                  60                  


Gly Leu Ile Ser Gln Tyr Arg Leu Ser Glu Ile Lys Pro Leu His Asn 
65                  70                  75                  80  


Phe Leu Thr Gln Leu Gln Pro Phe Leu Lys Leu Lys Gln Lys Gln Ala 
                85                  90                  95      


Asn Leu Val Leu Lys Ile Ile Glu Gln Leu Pro Ser Ala Lys Glu Ser 
            100                 105                 110         


Pro Asp Lys Phe Leu Glu Val Cys Thr Trp Val Asp Gln Ile Ala Ala 
        115                 120                 125             


Leu Asn Asp Ser Arg Thr Arg Lys Thr Thr Ser Glu Thr Val Arg Ala 
    130                 135                 140                 


Val Leu Asp 
145         


<210>  26
<211>  147
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthesized

<400>  26

Lys Glu Phe Leu Leu Tyr Leu Ala Gly Phe Val Asp Gly Asp Gly Ser 
1               5                   10                  15      


Ile Tyr Ala Cys Ile Leu Pro Asn Gln Gly Ser Lys Phe Lys His Ala 
            20                  25                  30          


Leu Gln Leu Phe Phe Thr Val Gly Gln Lys Thr Cys Arg Arg Trp Phe 
        35                  40                  45              


Leu Asp Lys Leu Val Asp Glu Ile Gly Val Gly Tyr Val His Asp His 
    50                  55                  60                  


Gly Leu Ile Ala Gln Tyr Arg Leu Ser Glu Ile Lys Pro Leu His Asn 
65                  70                  75                  80  


Phe Leu Thr Gln Leu Gln Pro Phe Leu Lys Leu Lys Gln Lys Gln Ala 
                85                  90                  95      


Asn Leu Val Leu Lys Ile Ile Glu Gln Leu Pro Ser Ala Lys Glu Ser 
            100                 105                 110         


Pro Asp Lys Phe Leu Glu Val Cys Thr Trp Val Asp Gln Ile Ala Ala 
        115                 120                 125             


Leu Asn Asp Ser Arg Thr Arg Lys Thr Thr Ser Glu Thr Val Arg Ala 
    130                 135                 140                 


Val Leu Asp 
145         


<210>  27
<211>  147
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthesized

<400>  27

Lys Glu Phe Leu Leu Tyr Leu Ala Gly Phe Val Asp Gly Asp Gly Ser 
1               5                   10                  15      


Ile Tyr Ala Cys Ile Leu Pro Asn Gln Gly Ser Lys Phe Lys His Ala 
            20                  25                  30          


Leu Gln Leu Phe Phe Thr Val Gly Gln Lys Thr Cys Arg Arg Trp Phe 
        35                  40                  45              


Leu Asp Lys Leu Val Asp Glu Ile Gly Val Gly Tyr Val Asn Asp Phe 
    50                  55                  60                  


Gly Pro Val Ser Gln Tyr Arg Leu Ser Glu Ile Lys Pro Leu His Asn 
65                  70                  75                  80  


Phe Leu Thr Gln Leu Gln Pro Phe Leu Lys Leu Lys Gln Lys Gln Ala 
                85                  90                  95      


Asn Leu Val Leu Lys Ile Ile Glu Gln Leu Pro Ser Ala Lys Glu Ser 
            100                 105                 110         


Pro Asp Lys Phe Leu Glu Val Cys Thr Trp Val Asp Gln Ile Ala Ala 
        115                 120                 125             


Leu Asn Asp Ser Arg Thr Arg Lys Thr Thr Ser Glu Thr Val Arg Ala 
    130                 135                 140                 


Val Leu Asp 
145         


<210>  28
<211>  147
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthesized

<400>  28

Lys Glu Phe Leu Leu Tyr Leu Ala Gly Phe Val Asp Gly Asp Gly Ser 
1               5                   10                  15      


Ile Tyr Ala Cys Ile Leu Pro Asn Gln Gly Ser Lys Phe Lys His Ala 
            20                  25                  30          


Leu Gln Leu Phe Phe Thr Val Gly Gln Lys Thr Cys Arg Arg Trp Phe 
        35                  40                  45              


Leu Asp Lys Leu Val Asp Glu Ile Gly Val Gly Tyr Val Gln Asp His 
    50                  55                  60                  


Gly Arg Ile Ser Gln Tyr Arg Leu Ser Glu Ile Lys Pro Leu His Asn 
65                  70                  75                  80  


Phe Leu Thr Gln Leu Gln Pro Phe Leu Lys Leu Lys Gln Lys Gln Ala 
                85                  90                  95      


Asn Leu Val Leu Lys Ile Ile Glu Gln Leu Pro Ser Ala Lys Glu Ser 
            100                 105                 110         


Pro Asp Lys Phe Leu Glu Val Cys Thr Trp Val Asp Gln Ile Ala Ala 
        115                 120                 125             


Leu Asn Asp Ser Arg Thr Arg Lys Thr Thr Ser Glu Thr Val Arg Ala 
    130                 135                 140                 


Val Leu Asp 
145         


<210>  29
<211>  147
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthesized

<400>  29

Lys Glu Phe Leu Leu Tyr Leu Ala Gly Phe Val Asp Gly Asp Gly Ser 
1               5                   10                  15      


Ile Tyr Ala Cys Ile Leu Pro Asn Gln Gly Ser Lys Phe Lys His Ala 
            20                  25                  30          


Leu Gln Leu Phe Phe Thr Val Gly Gln Lys Thr Cys Arg Arg Trp Phe 
        35                  40                  45              


Leu Asp Lys Leu Val Asp Glu Ile Gly Val Gly Tyr Val Gln Asp His 
    50                  55                  60                  


Gly Thr Ile Ser Gln Tyr Arg Leu Ser Glu Ile Lys Pro Leu His Asn 
65                  70                  75                  80  


Phe Leu Thr Gln Leu Gln Pro Phe Leu Lys Leu Lys Gln Lys Gln Ala 
                85                  90                  95      


Asn Leu Val Leu Lys Ile Ile Glu Gln Leu Pro Ser Ala Lys Glu Ser 
            100                 105                 110         


Pro Asp Lys Phe Leu Glu Val Cys Thr Trp Val Asp Gln Ile Ala Ala 
        115                 120                 125             


Leu Asn Asp Ser Arg Thr Arg Lys Thr Thr Ser Glu Thr Val Arg Ala 
    130                 135                 140                 


Val Leu Asp 
145         


<210>  30
<211>  147
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthesized

<400>  30

Lys Glu Phe Leu Leu Tyr Leu Ala Gly Phe Val Asp Gly Asp Gly Ser 
1               5                   10                  15      


Ile Tyr Ala Cys Ile Leu Pro Asn Gln Gly Ser Lys Phe Lys His Ala 
            20                  25                  30          


Leu Gln Leu Phe Phe Thr Val Gly Gln Lys Thr Cys Arg Arg Trp Phe 
        35                  40                  45              


Leu Asp Lys Leu Val Asp Glu Ile Gly Val Gly Tyr Val Gln Asp His 
    50                  55                  60                  


Gly Arg Ile Ser Gln Tyr Arg Leu Ser Glu Ile Lys Pro Leu His Asn 
65                  70                  75                  80  


Phe Leu Thr Gln Leu Gln Pro Phe Leu Lys Leu Lys Gln Lys Gln Ala 
                85                  90                  95      


Asn Leu Val Leu Lys Ile Ile Glu Gln Leu Pro Ser Ala Lys Glu Ser 
            100                 105                 110         


Pro Asp Lys Phe Leu Glu Val Cys Thr Trp Val Asp Gln Ile Ala Ala 
        115                 120                 125             


Leu Asn Asp Ser Arg Thr Arg Lys Thr Thr Ser Glu Thr Val Arg Ala 
    130                 135                 140                 


Val Leu Asp 
145         


<210>  31
<211>  147
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthesized

<400>  31

Lys Glu Phe Leu Leu Tyr Leu Ala Gly Phe Val Asp Gly Asp Gly Ser 
1               5                   10                  15      


Ile Tyr Ala Cys Ile Leu Pro Asn Gln Gly Ser Lys Phe Lys His Ala 
            20                  25                  30          


Leu Gln Leu Phe Phe Thr Val Gly Gln Lys Thr Cys Arg Arg Trp Phe 
        35                  40                  45              


Leu Asp Lys Leu Val Asp Glu Ile Gly Val Gly Tyr Val His Asp His 
    50                  55                  60                  


Gly Arg Ile Ser Gln Tyr Arg Leu Ser Glu Ile Lys Pro Leu His Asn 
65                  70                  75                  80  


Phe Leu Thr Gln Leu Gln Pro Phe Leu Lys Leu Lys Gln Lys Gln Ala 
                85                  90                  95      


Asn Leu Val Leu Lys Ile Ile Glu Gln Leu Pro Ser Ala Lys Glu Ser 
            100                 105                 110         


Pro Asp Lys Phe Leu Glu Val Cys Thr Trp Val Asp Gln Ile Ala Ala 
        115                 120                 125             


Leu Asn Asp Ser Arg Thr Arg Lys Thr Thr Ser Glu Thr Val Arg Ala 
    130                 135                 140                 


Val Leu Asp 
145         


<210>  32
<211>  147
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthesized

<400>  32

Lys Glu Phe Leu Leu Tyr Leu Ala Gly Phe Val Asp Gly Asp Gly Ser 
1               5                   10                  15      


Ile Tyr Ala Cys Ile Leu Pro Asn Gln Gly Ser Lys Phe Lys His Ala 
            20                  25                  30          


Leu Gln Leu Phe Phe Thr Val Gly Gln Lys Thr Cys Arg Arg Trp Phe 
        35                  40                  45              


Leu Asp Lys Leu Val Asp Glu Ile Gly Val Gly Tyr Val His Asp His 
    50                  55                  60                  


Gly Thr Ile Ser Gln Tyr Arg Leu Ser Glu Ile Lys Pro Leu His Asn 
65                  70                  75                  80  


Phe Leu Thr Gln Leu Gln Pro Phe Leu Lys Leu Lys Gln Lys Gln Ala 
                85                  90                  95      


Asn Leu Val Leu Lys Ile Ile Glu Gln Leu Pro Ser Ala Lys Glu Ser 
            100                 105                 110         


Pro Asp Lys Phe Leu Glu Val Cys Thr Trp Val Asp Gln Ile Ala Ala 
        115                 120                 125             


Leu Asn Asp Ser Arg Thr Arg Lys Thr Thr Ser Glu Thr Val Arg Ala 
    130                 135                 140                 


Val Leu Asp 
145         


<210>  33
<211>  1062
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Synthesized

<400>  33
atgaatacaa aatataataa agagttctta ctctacttag cagggtttgt agactctgac       60

ggttccatct ttgcccgtat cgagcctact caaagtgcta agttcaagca caagctgagg      120

ctcacgttcc gggtccatca gaagacacag cgccgttggt tcctcgacaa gctggtggac      180

gagatcggtg tgggttacgt gtatgacact ggcagcgtct ccgattacac tctgtcccag      240

atcaagcctt tgcataattt tttaacacaa ctacaacctt ttctaaaact aaaacaaaaa      300

caagcaaatt tagttttaaa aattattgaa caacttccgt cagcaaaaga atccccggac      360

aaattcttag aagtttgtac atgggtggat caaattgcag ctctgaatga ttcgaagacg      420

cgtaaaacaa cttctgaaac cgttcgtgct gtgctagaca gtttaccagg atccgtggga      480

ggtctatcgc catctcaggc atccagcgcc gcatcctcgg cttcctcaag cccgggttca      540

gggatctccg aagcactcag agctggagca ggttccggca ctggatacaa caaggaattc      600

ctgctctacc tggcgggctt cgtcgacggg gacggctcca tctatgcctg tatccttcct      660

aatcaaggga gtaagttcaa gcacgctctg cagctctttt tcacggtcgg ccagaagaca      720

tgccgccgtt ggttcctcga caagctggtg gacgagatcg gtgtgggtta cgtgcacgac      780

cacggcacta tctcgcagta ccgcctgtcc gagatcaagc ctctgcacaa cttcctgacc      840

cagctccagc ccttcctgaa gctcaagcag aagcaggcca acctcgtgct gaagatcatc      900

gagcagctgc cctccgccaa ggaatccccg gacaagttcc tggaggtgtg cacctgggtg      960

gaccagatcg ccgctctgaa cgactccagg acccgcaaga ccacttccga aaccgtccgc     1020

gccgttctag acagtctctc cgagaagaag aagtcgtccc cc                        1062


<210>  34
<211>  1062
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Synthesized

<400>  34
atgaatacaa aatataataa agagttctta ctctacttag cagggtttgt agacgctgac       60

ggttccatct ttgcccgtat cgagcctact caaagtgcta agttcaagca caagctgagg      120

ctcacgttcc gggtccatca gaagacacag cgccgttggt tcctcgacaa gctggtggac      180

gagatcggtg tgggttacgt gtatgacact ggcagcgtct ccgattacac tctgtccgag      240

atcaagcctt tgcataattt tttaacacaa ctacaacctt ttctaaaact aaaacaaaaa      300

caagcaaatt tagttttaaa aattattgaa caacttccgt cagcaaaaga atccccggac      360

aaattcttag aagtttgtac atgggtggat caaattgcag ctctgaatga ttcgaagacg      420

cgtaaaacaa cttctgaaac cgttcgtgct gtgctagaca gtttaccagg atccgtggga      480

ggtctatcgc catctcaggc atccagcgcc gcatcctcgg cttcctcaag cccgggttca      540

gggatctccg aagcactcag agctggagca ggttccggca ctggatacaa caaggaattc      600

ctgctctacc tggcgggctt cgtcgacggg gacggctcca tctatgcctg tatccttcct      660

aatcaaggga gtaagttcaa gcacgctctg cagctctttt tcacggtcgg ccagaagaca      720

tgccgccgtt ggttcctcga caagctggtg gacgagatcg gtgtgggtta cgtgaacgac      780

ttcggctcta tctcgcagta ccgcctgtcc gagatcaagc ctctgtacaa cttcctgacc      840

cagctccagc ccttcctgaa gctcaagcag aagcaggcca acctcgtgct gaagatcatc      900

gagcagctgc cctccgccaa ggaatccccg gacaagttcc tggaggtgtg cacctgggtg      960

gaccagatcg ccgctctgaa cgactccagg acccgcaaga ccacttccga aaccgtccgc     1020

gccgttctag acagtctctc cgagaagaag aagtcgtccc cc                        1062


<210>  35
<211>  1062
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Synthesized

<400>  35
atgaatacaa aatataataa agagttctta ctctacttag cagggtttgt agacgctgac       60

ggttccatct ttgcccgtat cgagcctact caaagtgcta agttcaagca caagctgagg      120

ctcacgttcc gggtccatca gaagacacag cgccgttggt tcctcgacaa gctggtggac      180

gagatcggtg tgggttacgt gtatgacact ggcagcgtct ccgattacac tctgtcccag      240

atcaagcctt tgcataattt tttaacacaa ctacaacctt ttctaaaact aaaacaaaaa      300

caagcaaatt tagttttaaa aattattgaa caacttccgt cagcaaaaga atccccggac      360

aaattcttag aagtttgtac atgggtggat caaattgcag ctctgaatga ttcgaagacg      420

cgtaaaacaa cttctgaaac cgttcgtgct gtgctagaca gtttaccagg atccgtggga      480

ggtctatcgc catctcaggc atccagcgcc gcatcctcgg cttcctcaag cccgggttca      540

gggatctccg aagcactcag agctggagca ggttccggca ctggatacaa caaggaattc      600

ctgctctacc tggcgggctt cgtcgacggg gacggctcca tctatgcctg tatccttcct      660

aatcaaggga gtaagttcaa gcacgctctg cagctctttt tcacggtcgg ccagaagaca      720

tgccgccgtt ggttcctcga caagctggtg gacgagatcg gtgtgggtta cgtgcacgac      780

ttcggcctga tctcgcagta ccgcctgtcc gagatcaagc ctctgcacaa cttcctgacc      840

cagctccagc ccttcctgaa gctcaagcag aagcaggcca acctcgtgct gaagatcatc      900

gagcagctgc cctccgccaa ggaatccccg gacaagttcc tggaggtgtg cacctgggtg      960

gaccagatcg ccgctctgaa cgactccagg acccgcaaga ccacttccga aaccgtccgc     1020

gccgttctag acagtctctc cgagaagaag aagtcgtccc cc                        1062


<210>  36
<211>  1062
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Synthesized

<400>  36
atgaatacaa aatataataa agagttctta ctctacttag cagggtttgt agacgctgac       60

ggttccatct ttgcccgtat cgagcctact caaagtgcta agttcaagca caagctgagg      120

ctcacgttcc gggtccatca gaagacacag cgccgttggt tcctcgacaa gctggtggac      180

gagatcggtg tgggttacgt gtatgacact ggcagcgtct ccgattacac tctgtccgag      240

atcaagcctt tgcataattt tttaacacaa ctacaacctt ttctaaaact aaaacaaaaa      300

caagcaaatt tagttttaaa aattattgaa caacttccgt cagcaaaaga atccccggac      360

aaattcttag aagtttgtac atgggtggat caaattgcag ctctgaatga ttcgaagacg      420

cgtaaaacaa cttctgaaac cgttcgtgct gtgctagaca gtttaccagg atccgtggga      480

ggtctatcgc catctcaggc atccagcgcc gcatcctcgg cttcctcaag cccgggttca      540

gggatctccg aagcacccag agctggagca ggttccggca ctggatacaa caaggaattc      600

ctgctctacc tggcgggctt cgtcgacggg gacggctcca tctatgcctg tatccttcct      660

aatcaaggga gtaagttcaa gcacgctctg cagctctttt tcacggtcgg ccagaagaca      720

tgccgccgtt ggttcctcga caagctggtg gacgagatcg gtgtgggtta cgtgcacgac      780

cacggcctta tcgcgcagta ccgcctgtcc gagatcaagc ctctgcacaa cttcctgacc      840

cagctccagc ccttcctgaa gctcaagcag aagcaggcca acctcgtgct gaagatcatc      900

gagcagctgc cctccgccaa ggaatccccg gacaagttcc tggaggtgtg cacctgggtg      960

gaccagatcg ccgctctgaa cgactccagg acccgcaaga ccacttccga aaccgtccgc     1020

gccgttctag acagtctctc cgagaagaag aagtcgtccc cc                        1062


<210>  37
<211>  1062
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Synthesized

<400>  37
atgaatacaa aatataataa agagttctta ctctacttag cagggtttgt agacgctgac       60

ggttccatct ttgcccgtat cgagcctact caaagtgcta agttcaagca caagctgagg      120

ctcacgttcc gggtccatca gaagacacag cgccgttggt tcctcgacaa gctggtggac      180

gagatcggtg tgggttacgt gtatgacact ggcagcgtct ccgattacac tctgtcccag      240

atcaagcctt tgcataattt tttaacacaa ctacaacctt ttctaaaact aaaacaaaaa      300

caagcaaatt tagttttaaa aattattgaa caacttccgt cagcaaaaga atccccggac      360

aaattcttag aagtttgtac atgggtggat caaattgcag ctctgaatga ttcgaagacg      420

cgtaaaacaa cttctgaaac tgttcgtgct gtgctagaca gtttaccagg atccgtggga      480

ggtctatcgc catctcaggc atccagcgcc gcatcctcgg cttcctcaag cccgggttca      540

gggatctccg aagcactcag agctggagca ggttccggca ctggatacaa caaggaattc      600

ctgctctacc tggcgggctt cgtcgacggg gacggctcca tctatgcctg tatccttcct      660

aatcaaggga gtaagttcaa gcacgctctg cagctctttt tcacggtcgg ccagaagaca      720

tgccgccgtt ggttcctcga caagctggtg gacgagatcg gtgtgggtta cgtgaacgac      780

ttcggccctg tctcgcagta ccgcctgtcc gagatcaagc ctctgcacaa cttcctgacc      840

cagctccagc ccttcctgaa gctcaagcag aagcaggcca acctcgtgct gaagatcatc      900

gagcagctgc cctccgccaa ggaatccccg gacaagttcc tggaggtgtg cacctgggtg      960

gaccagatcg ccgctctgaa cgactccagg acccgcaaga ccacttccga aaccgtccgc     1020

gccgttctag acagtctctc cgagaagaag aagtcgtccc cc                        1062


<210>  38
<211>  1062
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Synthesized

<400>  38
atgaatacaa aatataataa agagttctta ctctacttag cagggtttgt agacgctgac       60

ggttccatct ttgcccgtat cgagcctact caaagtgcta agttcaagca caagctgagg      120

ctcacgttcc gggtctggca gaagacacag cgccgttggt tcctcgacaa gctggtggac      180

gagatcggtg tgggttacgt gtatgacgag ggcagcgtct cctcttacac tctgtccgag      240

atcaagcctt tgcataattt tttaacacaa ctacaacctt ttctaaaact aaaacaaaaa      300

caagcaaatt tagttttaaa aattattgaa caacttccgt cagcaaaaga atccccggac      360

aaattcttag aagtttgtac atgggtggat caaattgcag ctctgaatga ttcgaagacg      420

cgtaaaacaa cttctgaaac cgttcgtgct gtgctagaca gtttaccagg atccgtggga      480

ggtctatcgc catctcaggc atccagcgcc gcatcctcgg cttcctcaag cccgggttca      540

gggatctccg aagcactcag agctggagca ggttccggca ctggatacaa caaggaattc      600

ctgctctacc tggcgggctt cgtcgacggg gacggctcca tctatgcctg tatccttcct      660

aatcaaggga gtaagttcaa gcacgctctg cagctattct tcacggtcgg ccagaagaca      720

tgccgccgtt ggttcctcga caagctggtg gacgagatcg gtgtgggtta cgtgcaggac      780

cacggcagga tctcgcagta ccgcctgtcc gagatcaagc ctctgcacaa cttcctgacc      840

cagctccagc ccttcctgaa gctcaagcag aagcaggcca acctcgtgct gaagatcatc      900

gagcagctgc cctccgccaa ggaatccccg gacaagttcc tggaggtgtg cacctgggtg      960

gaccagatcg ccgctctgaa cgactccagg acccgcaaga ccacttccga aaccgtccgc     1020

gccgttctag acagtctctc cgagaagaag aagtcgtccc cc                        1062


<210>  39
<211>  1062
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Synthesized

<400>  39
atgaatacaa aatataataa agagttctta ctctacttag cagggtttgt agactctgac       60

ggttccatct ttgcccgtat cgagcctact caaagtgcta agttcaagca caagctgagg      120

ctcacgttcc gggtccatca gaagacacag cgccgttggt tcctcgacaa gctggtggac      180

gagatcggtg tgggttacgt gtatgacact ggcagcgtct ccgattacac tctgtcccag      240

atcaagcctt tgcataattt tttaacacaa ctacaacctt ttctaaaact aaaacaaaaa      300

caagcaaatt tagttttaaa aattattgaa caacttccgt cagcaaaaga atccccggac      360

aaattcttag aagtttgtac atgggtggat caaattgcag ctctgaatga ttcgaagacg      420

cgtaaaacaa cttctgaaac cgttcgtgct gtgctagaca gtttaccagg atccgtggga      480

ggtctatcgc catctcaggc atccagcgcc gcatcctcgg cttcctcaag cccgggttca      540

gggatctccg aagcactcag agctggagca ggttccggca ctggatacaa caaggaattc      600

ctgctctacc tggcgggctt cgtcgacggg gacggctcca tctatgcctg tatccttcct      660

aatcaaggga gtaagttcaa gcacgctctg cagctctttt tcacggtcgg ccagaagaca      720

tgccgccgtt ggttcctcga caagctggtg gacgagatcg gtgtgggtta cgtgcaggac      780

cacggcacta tctcgcagta ccgcctgtcc gagatcaagc ctctgcacaa cttcctgacc      840

cagctccagc ccttcctgaa gctcaagcag aagcaggcca acctcgtgct gaagatcatc      900

gagcagctgc cctccgccaa ggaatccccg gacaagttcc tggaggtgtg cacctgggtg      960

gaccagatcg ccgctctgaa cgactccagg acccgcaaga ccacttccga aaccgtccgc     1020

gccgttctag acagtctctc cgagaagaag aagtcgtccc cc                        1062


<210>  40
<211>  1062
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Synthesized

<400>  40
atgaatacaa aatataataa agagttctta ctctacttag cagggtttgt agactctgac       60

ggttccatct ttgcccgtat cgagcctact caaagtgcta agttcaagca caagctgagg      120

ctcacgttcc gggtctggca gaagacacag cgccgttggt tcctcgacaa gctggtggac      180

gagatcggtg tgggttacgt gtatgacgag ggcagcgtct cctcttacac tctgtccgag      240

atcaagcctt tgcataattt tttaacacaa ctacaacctt ttctaaaact aaaacaaaaa      300

caagcaaatt tagttttaaa aattattgaa caacttccgt cagcaaaaga atccccggac      360

aaattcttag aagtttgtac atgggtggat caaattgcag ctctgaatga ttcgaagacg      420

cgtaaaacaa cttctgaaac cgttcgtgct gtgctagaca gtttaccagg atccgtggga      480

ggtctatcgc catctcaggc atccagcgcc gcatcctcgg cttcctcaag cccgggttca      540

gggatctccg aagcactcag agctggagca ggttccggca ctggatacaa caaggaattc      600

ctgctctacc tggcgggctt cgtcgacggg gacggctcca tctatgcctg tatccttcct      660

aatcaaggga gtaagttcaa gcacgctctg cagctattct tcacggtcgg ccagaagaca      720

tgccgccgtt ggttcctcga caagctggtg gacgagatcg gtgtgggtta cgtgcaggac      780

cacggcagga tctcgcagta ccgcctgtcc gagatcaagc ctctgcacaa cttcctgacc      840

cagctccagc ccttcctgaa gctcaagcag aagcaggcca acctcgtgct gaagatcatc      900

gagcagctgc cctccgccaa ggaatccccg gacaagttcc tggaggtgtg cacctgggtg      960

gaccagatcg ccgctctgaa cgactccagg acccgcaaga ccacttccga aaccgtccgc     1020

gccgttctag acagtctctc cgagaagaag aagtcgtccc cc                        1062


<210>  41
<211>  1062
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Synthesized

<400>  41
atgaatacaa aatataataa agagttctta ctctacttag cagggtttgt agactctgac       60

ggttccatct ttgcccgtat cgagcctact caaagtgcta agttcaagca caagctgagg      120

ctcacgttcc gggtccatca gaagacacag cgccgttggt tcctcgacaa gctggtggac      180

gagatcggtg tgggttacgt gtatgacact ggcagcgtct ccgattacac tctgtcccag      240

atcaagcctt tgcataattt tttaacacaa ctacaacctt ttctaaaact aaaacaaaaa      300

caagcaaatt tagttttaaa aattattgaa caacttccgt cagcaaaaga atccccggac      360

aaattcttag aagtttgtac atgggtggat caaattgcag ctctgaatga ttcgaagacg      420

cgtaaaacaa cttctgaaac cgttcgtgct gtgctagaca gtttaccagg atccgtggga      480

ggtctatcgc catctcaggc atccagcgcc gcatcctcgg cttcctcaag cccgggttca      540

gggatctccg aagcactcag agctggagca ggttccggca ctggatacaa caaggaattc      600

ctgctctacc tggcgggctt cgtcgacggg gacggctcca tctatgcctg tatccttcct      660

aatcaaggga gtaagttcaa gcacgctctg cagctctttt tcacggtcgg ccagaagaca      720

tgccgccgtt ggttcctcga caagctggtg gacgagatcg gtgtgggtta cgtgcacgac      780

cacggcagga tctcgcagta ccgcctgtcc gagatcaagc ctctgcacaa cttcctgacc      840

cagctccagc ccttcctgaa gctcaagcag aagcaggcca acctcgtgct gaagatcatc      900

gagcagctgc cctccgccaa ggaatccccg gacaagttcc tggaggtgtg cacctgggtg      960

gaccagatcg ccgctctgaa cgactccagg acccgcaaga ccacttccga aaccgtccgc     1020

gccgttctag acagtctctc cgagaagaag aagtcgtccc cc                        1062


<210>  42
<211>  1062
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Synthesized

<400>  42
atgaatacaa aatataataa agagttctta ctctacttag cagggtttgt agactctgac       60

ggttccatct ttgcccgtat cgagcctact caaagtgcta agttcaagca caagctgagg      120

ctcacgttcc gggtctggca gaagacacag cgccgttggt tcctcgacaa gctggtggac      180

gagatcggtg tgggttacgt gtatgacact ggcagcgtct ccgattacac tctgtcccag      240

atcaagcctt tgcataattt tttaacacaa ctacaacctt ttctaaaact aaaacaaaaa      300

caagcaaatt tagttttaaa aattattgaa caacttccgt cagcaaaaga atccccggac      360

aaattcttag aagtttgtac atgggtggat caaattgcag ctctgaatga ttcgaagacg      420

cgtaaaacaa cttctgaaac cgttcgtgct gtgctagaca gtttaccagg atccgtggga      480

ggtctatcgc catctcaggc atccagcgcc gcatcctcgg cttcctcaag cccgggttca      540

gggatctccg aagcactcag agctggagca ggttccggca ctggatacaa caaggaattc      600

ctgctctacc tggcgggctt cgtcgacggg gacggctcca tctatgcctg tatccttcct      660

aatcaaggga gtaagttcaa gcacgctctg cagctctttt tcacggtcgg ccagaagaca      720

tgccgccgtt ggttcctcga caagctggtg gacgagatcg gtgtgggtta cgtgcacgac      780

cacggcacta tctcgcagta ccgcctgtcc gagatcaagc ctctgcacaa cttcctgacc      840

cagctccagc ccttcctgaa gctcaagcag aagcaggcca acctcgtgct gaagatcatc      900

gagcagctgc cctccgccaa ggaatccccg gacaagttcc tggaggtgtg cacctgggtg      960

gaccagatcg ccgctctgaa cgactccagg acccgcaaga ccacttccga aaccgtccgc     1020

gccgttctag acagtctctc cgagaagaag aagtcgtccc cc                        1062


<210>  43
<211>  35
<212>  PRT
<213>  Homo sapiens

<400>  43

Met Ser Val Leu Thr Pro Leu Leu Leu Arg Gly Leu Thr Gly Ser Ala 
1               5                   10                  15      


Arg Arg Leu Pro Val Pro Arg Ala Lys Ile His Ser Leu Pro Pro Glu 
            20                  25                  30          


Gly Lys Leu 
        35  


<210>  44
<211>  63
<212>  PRT
<213>  Neurospora crassa

<400>  44

Met Ala Ser Thr Arg Val Leu Ala Ser Arg Leu Ala Ser Gln Met Ala 
1               5                   10                  15      


Ala Ser Ala Lys Val Ala Arg Pro Ala Val Arg Val Ala Gln Val Ser 
            20                  25                  30          


Lys Arg Thr Ile Gln Thr Gly Ser Pro Leu Gln Thr Leu Lys Arg Thr 
        35                  40                  45              


Gln Met Thr Ser Ile Val Asn Ala Thr Thr Arg Gln Ala Phe Gln 
    50                  55                  60              


<210>  45
<211>  98
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthesized

<400>  45

Met Ser Val Leu Thr Pro Leu Leu Leu Arg Gly Leu Thr Gly Ser Ala 
1               5                   10                  15      


Arg Arg Leu Pro Val Pro Arg Ala Lys Ile His Ser Leu Pro Pro Glu 
            20                  25                  30          


Gly Lys Leu Met Ala Ser Thr Arg Val Leu Ala Ser Arg Leu Ala Ser 
        35                  40                  45              


Gln Met Ala Ala Ser Ala Lys Val Ala Arg Pro Ala Val Arg Val Ala 
    50                  55                  60                  


Gln Val Ser Lys Arg Thr Ile Gln Thr Gly Ser Pro Leu Gln Thr Leu 
65                  70                  75                  80  


Lys Arg Thr Gln Met Thr Ser Ile Val Asn Ala Thr Thr Arg Gln Ala 
                85                  90                  95      


Phe Gln 
        


<210>  46
<211>  18
<212>  PRT
<213>  Mouse parovirus NS2

<400>  46

Val Asp Glu Met Thr Lys Lys Phe Gly Thr Leu Thr Ile His Asp Thr 
1               5                   10                  15      


Glu Lys 
        


<210>  47
<211>  10
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthesized

<400>  47

Leu Gly Ala Gly Leu Gly Ala Leu Gly Leu 
1               5                   10  


<210>  48
<211>  163
<212>  PRT
<213>  Chlamydomonas reinhardtii

<400>  48

Met Asn Thr Lys Tyr Asn Lys Glu Phe Leu Leu Tyr Leu Ala Gly Phe 
1               5                   10                  15      


Val Asp Gly Asp Gly Ser Ile Ile Ala Gln Ile Lys Pro Asn Gln Ser 
            20                  25                  30          


Tyr Lys Phe Lys His Gln Leu Ser Leu Ala Phe Gln Val Thr Gln Lys 
        35                  40                  45              


Thr Gln Arg Arg Trp Phe Leu Asp Lys Leu Val Asp Glu Ile Gly Val 
    50                  55                  60                  


Gly Tyr Val Arg Asp Arg Gly Ser Val Ser Asp Tyr Ile Leu Ser Glu 
65                  70                  75                  80  


Ile Lys Pro Leu His Asn Phe Leu Thr Gln Leu Gln Pro Phe Leu Lys 
                85                  90                  95      


Leu Lys Gln Lys Gln Ala Asn Leu Val Leu Lys Ile Ile Trp Arg Leu 
            100                 105                 110         


Pro Ser Ala Lys Glu Ser Pro Asp Lys Phe Leu Glu Val Cys Thr Trp 
        115                 120                 125             


Val Asp Gln Ile Ala Ala Leu Asn Asp Ser Lys Thr Arg Lys Thr Thr 
    130                 135                 140                 


Ser Glu Thr Val Arg Ala Val Leu Asp Ser Leu Ser Glu Lys Lys Lys 
145                 150                 155                 160 


Ser Ser Pro 
            


<210>  49
<211>  20
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Synthesized

<400>  49
agccccgggt actccttgtt                                                   20


<210>  50
<211>  18
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Synthesized

<400>  50
ttccttgcag gaacagag                                                     18


<210>  51
<211>  17
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Synthesized

<400>  51
ctgcttgacc acccatt                                                      17


<210>  52
<211>  19
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Synthesized

<400>  52
ccagcaggcc aggtacacc                                                    19


<210>  53
<211>  16
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Synthesized

<400>  53
accgccaagg atgcac                                                       16


<210>  54
<211>  16
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Synthesized

<400>  54
gcgggtggga atggag                                                       16


<210>  55
<211>  27
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Synthesized

<400>  55
gctggctagc gtttaaactt aagcttg                                           27


<210>  56
<211>  34
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Synthesized

<400>  56
gggtatgttg ttaagaagag gaattgaacc tctg                                   34


<210>  57
<211>  31
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Synthesized

<400>  57
tgtgagtgca tataatgaaa tgggatgaca g                                      31


<210>  58
<211>  29
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Synthesized

<400>  58
cagtccccac ctcttaagtt tcaaatgac                                         29


<210>  59
<211>  20
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Synthesized

<400>  59
ccgcaagccc cttggtactg                                                   20


<210>  60
<211>  23
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Synthesized

<400>  60
gtctgcactc aaggaaggag ctc                                               23


<210>  61
<211>  32
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Synthesized

<400>  61
gaccttatgc tgaggaaaag ctgtcattct ag                                     32


<210>  62
<211>  32
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Synthesized

<400>  62
ggccatttat ttcagagttt agatcgctat gc                                     32


<210>  63
<211>  14
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Synthesized

<400>  63
tggcagggcc cggt                                                         14


<210>  64
<211>  22
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Synthesized

<400>  64
cccaagaaca gggtttgtta ag                                                22


<210>  65
<211>  19
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Synthesized

<400>  65
ggaatgccat tgcgattag                                                    19


<210>  66
<211>  26
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Synthesized

<400>  66
agcagttcta ccgtacaacc ctaaca                                            26


<210>  67
<211>  18
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Synthesized

<400>  67
ggcagttgag gtggatta                                                     18


<210>  68
<211>  20
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Synthesized

<400>  68
ggaatgcggt agtagttagg                                                   20


<210>  69
<211>  24
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Synthesized

<400>  69
aaccagacaa atcgctccac caac                                              24


<210>  70
<211>  19
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Synthesized

<400>  70
cggacaggat tgacagatt                                                    19


<210>  71
<211>  20
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Synthesized

<400>  71
ccagagtctc gttcgttatc                                                   20


<210>  72
<211>  15
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Synthesized

<400>  72
accgggctct gccat                                                        15


