                         SEQUENCE LISTING

<110>  The Trustees of the University of Pennsylvania
 
<120>  NOVEL COMPOSITIONS WITH TISSUE-SPECIFIC TARGETING MOTIFS AND 
       COMPOSITIONS CONTAINING SAME

<130>  UPN-21-9637.PCT

<140>  PCT/US22/25879
<141>  2022-04-22

<150>  US 63/178,881
<151>  2021-04-23

<160>  65    

<170>  PatentIn version 3.5

<210>  1
<211>  13
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  YGY peptide sequence

<400>  1

Tyr Gly Tyr Gly Asn Pro Ala Thr Arg Tyr Phe Asp Val 
1               5                   10              


<210>  2
<211>  13
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  YGY2A peptide sequence

<400>  2

Tyr Ala Tyr Gly Asn Pro Ala Thr Arg Tyr Phe Asp Val 
1               5                   10              


<210>  3
<211>  13
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  YGY2K peptide sequence

<400>  3

Tyr Lys Tyr Gly Asn Pro Ala Thr Arg Tyr Phe Asp Val 
1               5                   10              


<210>  4
<211>  13
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  YGY2R peptide sequence

<400>  4

Tyr Arg Tyr Gly Asn Pro Ala Thr Arg Tyr Phe Asp Val 
1               5                   10              


<210>  5
<211>  13
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  YGY3H peptide sequence

<400>  5

Tyr Gly His Gly Asn Pro Ala Thr Arg Tyr Phe Asp Val 
1               5                   10              


<210>  6
<211>  13
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  YGY8R peptide sequence

<400>  6

Tyr Gly Tyr Gly Asn Pro Ala Arg Arg Tyr Phe Asp Val 
1               5                   10              


<210>  7
<211>  13
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  YGY8H peptide sequence

<400>  7

Tyr Gly Tyr Gly Asn Pro Ala His Arg Tyr Phe Asp Val 
1               5                   10              


<210>  8
<211>  13
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  YGY13K peptide sequence

<400>  8

Tyr Gly Tyr Gly Asn Pro Ala Thr Arg Tyr Phe Asp Lys 
1               5                   10              


<210>  9
<211>  736
<212>  PRT
<213>  adeno-associated virus 9

<400>  9

Met Ala Ala Asp Gly Tyr Leu Pro Asp Trp Leu Glu Asp Asn Leu Ser 
1               5                   10                  15      


Glu Gly Ile Arg Glu Trp Trp Ala Leu Lys Pro Gly Ala Pro Gln Pro 
            20                  25                  30          


Lys Ala Asn Gln Gln His Gln Asp Asn Ala Arg Gly Leu Val Leu Pro 
        35                  40                  45              


Gly Tyr Lys Tyr Leu Gly Pro Gly Asn Gly Leu Asp Lys Gly Glu Pro 
    50                  55                  60                  


Val Asn Ala Ala Asp Ala Ala Ala Leu Glu His Asp Lys Ala Tyr Asp 
65                  70                  75                  80  


Gln Gln Leu Lys Ala Gly Asp Asn Pro Tyr Leu Lys Tyr Asn His Ala 
                85                  90                  95      


Asp Ala Glu Phe Gln Glu Arg Leu Lys Glu Asp Thr Ser Phe Gly Gly 
            100                 105                 110         


Asn Leu Gly Arg Ala Val Phe Gln Ala Lys Lys Arg Leu Leu Glu Pro 
        115                 120                 125             


Leu Gly Leu Val Glu Glu Ala Ala Lys Thr Ala Pro Gly Lys Lys Arg 
    130                 135                 140                 


Pro Val Glu Gln Ser Pro Gln Glu Pro Asp Ser Ser Ala Gly Ile Gly 
145                 150                 155                 160 


Lys Ser Gly Ala Gln Pro Ala Lys Lys Arg Leu Asn Phe Gly Gln Thr 
                165                 170                 175     


Gly Asp Thr Glu Ser Val Pro Asp Pro Gln Pro Ile Gly Glu Pro Pro 
            180                 185                 190         


Ala Ala Pro Ser Gly Val Gly Ser Leu Thr Met Ala Ser Gly Gly Gly 
        195                 200                 205             


Ala Pro Val Ala Asp Asn Asn Glu Gly Ala Asp Gly Val Gly Ser Ser 
    210                 215                 220                 


Ser Gly Asn Trp His Cys Asp Ser Gln Trp Leu Gly Asp Arg Val Ile 
225                 230                 235                 240 


Thr Thr Ser Thr Arg Thr Trp Ala Leu Pro Thr Tyr Asn Asn His Leu 
                245                 250                 255     


Tyr Lys Gln Ile Ser Asn Ser Thr Ser Gly Gly Ser Ser Asn Asp Asn 
            260                 265                 270         


Ala Tyr Phe Gly Tyr Ser Thr Pro Trp Gly Tyr Phe Asp Phe Asn Arg 
        275                 280                 285             


Phe His Cys His Phe Ser Pro Arg Asp Trp Gln Arg Leu Ile Asn Asn 
    290                 295                 300                 


Asn Trp Gly Phe Arg Pro Lys Arg Leu Asn Phe Lys Leu Phe Asn Ile 
305                 310                 315                 320 


Gln Val Lys Glu Val Thr Asp Asn Asn Gly Val Lys Thr Ile Ala Asn 
                325                 330                 335     


Asn Leu Thr Ser Thr Val Gln Val Phe Thr Asp Ser Asp Tyr Gln Leu 
            340                 345                 350         


Pro Tyr Val Leu Gly Ser Ala His Glu Gly Cys Leu Pro Pro Phe Pro 
        355                 360                 365             


Ala Asp Val Phe Met Ile Pro Gln Tyr Gly Tyr Leu Thr Leu Asn Asp 
    370                 375                 380                 


Gly Ser Gln Ala Val Gly Arg Ser Ser Phe Tyr Cys Leu Glu Tyr Phe 
385                 390                 395                 400 


Pro Ser Gln Met Leu Arg Thr Gly Asn Asn Phe Gln Phe Ser Tyr Glu 
                405                 410                 415     


Phe Glu Asn Val Pro Phe His Ser Ser Tyr Ala His Ser Gln Ser Leu 
            420                 425                 430         


Asp Arg Leu Met Asn Pro Leu Ile Asp Gln Tyr Leu Tyr Tyr Leu Ser 
        435                 440                 445             


Lys Thr Ile Asn Gly Ser Gly Gln Asn Gln Gln Thr Leu Lys Phe Ser 
    450                 455                 460                 


Val Ala Gly Pro Ser Asn Met Ala Val Gln Gly Arg Asn Tyr Ile Pro 
465                 470                 475                 480 


Gly Pro Ser Tyr Arg Gln Gln Arg Val Ser Thr Thr Val Thr Gln Asn 
                485                 490                 495     


Asn Asn Ser Glu Phe Ala Trp Pro Gly Ala Ser Ser Trp Ala Leu Asn 
            500                 505                 510         


Gly Arg Asn Ser Leu Met Asn Pro Gly Pro Ala Met Ala Ser His Lys 
        515                 520                 525             


Glu Gly Glu Asp Arg Phe Phe Pro Leu Ser Gly Ser Leu Ile Phe Gly 
    530                 535                 540                 


Lys Gln Gly Thr Gly Arg Asp Asn Val Asp Ala Asp Lys Val Met Ile 
545                 550                 555                 560 


Thr Asn Glu Glu Glu Ile Lys Thr Thr Asn Pro Val Ala Thr Glu Ser 
                565                 570                 575     


Tyr Gly Gln Val Ala Thr Asn His Gln Ser Ala Gln Ala Gln Ala Gln 
            580                 585                 590         


Thr Gly Trp Val Gln Asn Gln Gly Ile Leu Pro Gly Met Val Trp Gln 
        595                 600                 605             


Asp Arg Asp Val Tyr Leu Gln Gly Pro Ile Trp Ala Lys Ile Pro His 
    610                 615                 620                 


Thr Asp Gly Asn Phe His Pro Ser Pro Leu Met Gly Gly Phe Gly Met 
625                 630                 635                 640 


Lys His Pro Pro Pro Gln Ile Leu Ile Lys Asn Thr Pro Val Pro Ala 
                645                 650                 655     


Asp Pro Pro Thr Ala Phe Asn Lys Asp Lys Leu Asn Ser Phe Ile Thr 
            660                 665                 670         


Gln Tyr Ser Thr Gly Gln Val Ser Val Glu Ile Glu Trp Glu Leu Gln 
        675                 680                 685             


Lys Glu Asn Ser Lys Arg Trp Asn Pro Glu Ile Gln Tyr Thr Ser Asn 
    690                 695                 700                 


Tyr Tyr Lys Ser Asn Asn Val Glu Phe Ala Val Asn Thr Glu Gly Val 
705                 710                 715                 720 


Tyr Ser Glu Pro Arg Pro Ile Gly Thr Arg Tyr Leu Thr Arg Asn Leu 
                725                 730                 735     


<210>  10
<211>  736
<212>  PRT
<213>  adeno-associated virus hu68

<400>  10

Met Ala Ala Asp Gly Tyr Leu Pro Asp Trp Leu Glu Asp Asn Leu Ser 
1               5                   10                  15      


Glu Gly Ile Arg Glu Trp Trp Ala Leu Lys Pro Gly Ala Pro Gln Pro 
            20                  25                  30          


Lys Ala Asn Gln Gln His Gln Asp Asn Ala Arg Gly Leu Val Leu Pro 
        35                  40                  45              


Gly Tyr Lys Tyr Leu Gly Pro Gly Asn Gly Leu Asp Lys Gly Glu Pro 
    50                  55                  60                  


Val Asn Glu Ala Asp Ala Ala Ala Leu Glu His Asp Lys Ala Tyr Asp 
65                  70                  75                  80  


Gln Gln Leu Lys Ala Gly Asp Asn Pro Tyr Leu Lys Tyr Asn His Ala 
                85                  90                  95      


Asp Ala Glu Phe Gln Glu Arg Leu Lys Glu Asp Thr Ser Phe Gly Gly 
            100                 105                 110         


Asn Leu Gly Arg Ala Val Phe Gln Ala Lys Lys Arg Leu Leu Glu Pro 
        115                 120                 125             


Leu Gly Leu Val Glu Glu Ala Ala Lys Thr Ala Pro Gly Lys Lys Arg 
    130                 135                 140                 


Pro Val Glu Gln Ser Pro Gln Glu Pro Asp Ser Ser Val Gly Ile Gly 
145                 150                 155                 160 


Lys Ser Gly Ala Gln Pro Ala Lys Lys Arg Leu Asn Phe Gly Gln Thr 
                165                 170                 175     


Gly Asp Thr Glu Ser Val Pro Asp Pro Gln Pro Ile Gly Glu Pro Pro 
            180                 185                 190         


Ala Ala Pro Ser Gly Val Gly Ser Leu Thr Met Ala Ser Gly Gly Gly 
        195                 200                 205             


Ala Pro Val Ala Asp Asn Asn Glu Gly Ala Asp Gly Val Gly Ser Ser 
    210                 215                 220                 


Ser Gly Asn Trp His Cys Asp Ser Gln Trp Leu Gly Asp Arg Val Ile 
225                 230                 235                 240 


Thr Thr Ser Thr Arg Thr Trp Ala Leu Pro Thr Tyr Asn Asn His Leu 
                245                 250                 255     


Tyr Lys Gln Ile Ser Asn Ser Thr Ser Gly Gly Ser Ser Asn Asp Asn 
            260                 265                 270         


Ala Tyr Phe Gly Tyr Ser Thr Pro Trp Gly Tyr Phe Asp Phe Asn Arg 
        275                 280                 285             


Phe His Cys His Phe Ser Pro Arg Asp Trp Gln Arg Leu Ile Asn Asn 
    290                 295                 300                 


Asn Trp Gly Phe Arg Pro Lys Arg Leu Asn Phe Lys Leu Phe Asn Ile 
305                 310                 315                 320 


Gln Val Lys Glu Val Thr Asp Asn Asn Gly Val Lys Thr Ile Ala Asn 
                325                 330                 335     


Asn Leu Thr Ser Thr Val Gln Val Phe Thr Asp Ser Asp Tyr Gln Leu 
            340                 345                 350         


Pro Tyr Val Leu Gly Ser Ala His Glu Gly Cys Leu Pro Pro Phe Pro 
        355                 360                 365             


Ala Asp Val Phe Met Ile Pro Gln Tyr Gly Tyr Leu Thr Leu Asn Asp 
    370                 375                 380                 


Gly Ser Gln Ala Val Gly Arg Ser Ser Phe Tyr Cys Leu Glu Tyr Phe 
385                 390                 395                 400 


Pro Ser Gln Met Leu Arg Thr Gly Asn Asn Phe Gln Phe Ser Tyr Glu 
                405                 410                 415     


Phe Glu Asn Val Pro Phe His Ser Ser Tyr Ala His Ser Gln Ser Leu 
            420                 425                 430         


Asp Arg Leu Met Asn Pro Leu Ile Asp Gln Tyr Leu Tyr Tyr Leu Ser 
        435                 440                 445             


Lys Thr Ile Asn Gly Ser Gly Gln Asn Gln Gln Thr Leu Lys Phe Ser 
    450                 455                 460                 


Val Ala Gly Pro Ser Asn Met Ala Val Gln Gly Arg Asn Tyr Ile Pro 
465                 470                 475                 480 


Gly Pro Ser Tyr Arg Gln Gln Arg Val Ser Thr Thr Val Thr Gln Asn 
                485                 490                 495     


Asn Asn Ser Glu Phe Ala Trp Pro Gly Ala Ser Ser Trp Ala Leu Asn 
            500                 505                 510         


Gly Arg Asn Ser Leu Met Asn Pro Gly Pro Ala Met Ala Ser His Lys 
        515                 520                 525             


Glu Gly Glu Asp Arg Phe Phe Pro Leu Ser Gly Ser Leu Ile Phe Gly 
    530                 535                 540                 


Lys Gln Gly Thr Gly Arg Asp Asn Val Asp Ala Asp Lys Val Met Ile 
545                 550                 555                 560 


Thr Asn Glu Glu Glu Ile Lys Thr Thr Asn Pro Val Ala Thr Glu Ser 
                565                 570                 575     


Tyr Gly Gln Val Ala Thr Asn His Gln Ser Ala Gln Ala Gln Ala Gln 
            580                 585                 590         


Thr Gly Trp Val Gln Asn Gln Gly Ile Leu Pro Gly Met Val Trp Gln 
        595                 600                 605             


Asp Arg Asp Val Tyr Leu Gln Gly Pro Ile Trp Ala Lys Ile Pro His 
    610                 615                 620                 


Thr Asp Gly Asn Phe His Pro Ser Pro Leu Met Gly Gly Phe Gly Met 
625                 630                 635                 640 


Lys His Pro Pro Pro Gln Ile Leu Ile Lys Asn Thr Pro Val Pro Ala 
                645                 650                 655     


Asp Pro Pro Thr Ala Phe Asn Lys Asp Lys Leu Asn Ser Phe Ile Thr 
            660                 665                 670         


Gln Tyr Ser Thr Gly Gln Val Ser Val Glu Ile Glu Trp Glu Leu Gln 
        675                 680                 685             


Lys Glu Asn Ser Lys Arg Trp Asn Pro Glu Ile Gln Tyr Thr Ser Asn 
    690                 695                 700                 


Tyr Tyr Lys Ser Asn Asn Val Glu Phe Ala Val Asn Thr Glu Gly Val 
705                 710                 715                 720 


Tyr Ser Glu Pro Arg Pro Ile Gly Thr Arg Tyr Leu Thr Arg Asn Leu 
                725                 730                 735     


<210>  11
<211>  7
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  PHP.B peptide sequence

<400>  11

Thr Leu Ala Val Pro Phe Lys 
1               5           


<210>  12
<211>  7
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  AAV2 variant peptide sequence

<400>  12

Asn Asp Val Arg Ala Val Ser 
1               5           


<210>  13
<211>  621
<212>  PRT
<213>  adeno-associated virus 2

<400>  13

Met Pro Gly Phe Tyr Glu Ile Val Ile Lys Val Pro Ser Asp Leu Asp 
1               5                   10                  15      


Glu His Leu Pro Gly Ile Ser Asp Ser Phe Val Asn Trp Val Ala Glu 
            20                  25                  30          


Lys Glu Trp Glu Leu Pro Pro Asp Ser Asp Met Asp Leu Asn Leu Ile 
        35                  40                  45              


Glu Gln Ala Pro Leu Thr Val Ala Glu Lys Leu Gln Arg Asp Phe Leu 
    50                  55                  60                  


Thr Glu Trp Arg Arg Val Ser Lys Ala Pro Glu Ala Leu Phe Phe Val 
65                  70                  75                  80  


Gln Phe Glu Lys Gly Glu Ser Tyr Phe His Met His Val Leu Val Glu 
                85                  90                  95      


Thr Thr Gly Val Lys Ser Met Val Leu Gly Arg Phe Leu Ser Gln Ile 
            100                 105                 110         


Arg Glu Lys Leu Ile Gln Arg Ile Tyr Arg Gly Ile Glu Pro Thr Leu 
        115                 120                 125             


Pro Asn Trp Phe Ala Val Thr Lys Thr Arg Asn Gly Ala Gly Gly Gly 
    130                 135                 140                 


Asn Lys Val Val Asp Glu Cys Tyr Ile Pro Asn Tyr Leu Leu Pro Lys 
145                 150                 155                 160 


Thr Gln Pro Glu Leu Gln Trp Ala Trp Thr Asn Met Glu Gln Tyr Leu 
                165                 170                 175     


Ser Ala Cys Leu Asn Leu Thr Glu Arg Lys Arg Leu Val Ala Gln His 
            180                 185                 190         


Leu Thr His Val Ser Gln Thr Gln Glu Gln Asn Lys Glu Asn Gln Asn 
        195                 200                 205             


Pro Asn Ser Asp Ala Pro Val Ile Arg Ser Lys Thr Ser Ala Arg Tyr 
    210                 215                 220                 


Met Glu Leu Val Gly Trp Leu Val Asp Lys Gly Ile Thr Ser Glu Lys 
225                 230                 235                 240 


Gln Trp Ile Gln Glu Asp Gln Ala Ser Tyr Ile Ser Phe Asn Ala Ala 
                245                 250                 255     


Ser Asn Ser Arg Ser Gln Ile Lys Ala Ala Leu Asp Asn Ala Gly Lys 
            260                 265                 270         


Ile Met Ser Leu Thr Lys Thr Ala Pro Asp Tyr Leu Val Gly Gln Gln 
        275                 280                 285             


Pro Val Glu Asp Ile Ser Ser Asn Arg Ile Tyr Lys Ile Leu Glu Leu 
    290                 295                 300                 


Asn Gly Tyr Asp Pro Gln Tyr Ala Ala Ser Val Phe Leu Gly Trp Ala 
305                 310                 315                 320 


Thr Lys Lys Phe Gly Lys Arg Asn Thr Ile Trp Leu Phe Gly Pro Ala 
                325                 330                 335     


Thr Thr Gly Lys Thr Asn Ile Ala Glu Ala Ile Ala His Thr Val Pro 
            340                 345                 350         


Phe Tyr Gly Cys Val Asn Trp Thr Asn Glu Asn Phe Pro Phe Asn Asp 
        355                 360                 365             


Cys Val Asp Lys Met Val Ile Trp Trp Glu Glu Gly Lys Met Thr Ala 
    370                 375                 380                 


Lys Val Val Glu Ser Ala Lys Ala Ile Leu Gly Gly Ser Lys Val Arg 
385                 390                 395                 400 


Val Asp Gln Lys Cys Lys Ser Ser Ala Gln Ile Asp Pro Thr Pro Val 
                405                 410                 415     


Ile Val Thr Ser Asn Thr Asn Met Cys Ala Val Ile Asp Gly Asn Ser 
            420                 425                 430         


Thr Thr Phe Glu His Gln Gln Pro Leu Gln Asp Arg Met Phe Lys Phe 
        435                 440                 445             


Glu Leu Thr Arg Arg Leu Asp His Asp Phe Gly Lys Val Thr Lys Gln 
    450                 455                 460                 


Glu Val Lys Asp Phe Phe Arg Trp Ala Lys Asp His Val Val Glu Val 
465                 470                 475                 480 


Glu His Glu Phe Tyr Val Lys Lys Gly Gly Ala Lys Lys Arg Pro Ala 
                485                 490                 495     


Pro Ser Asp Ala Asp Ile Ser Glu Pro Lys Arg Val Arg Glu Ser Val 
            500                 505                 510         


Ala Gln Pro Ser Thr Ser Asp Ala Glu Ala Ser Ile Asn Tyr Ala Asp 
        515                 520                 525             


Arg Tyr Gln Asn Lys Cys Ser Arg His Val Gly Met Asn Leu Met Leu 
    530                 535                 540                 


Phe Pro Cys Arg Gln Cys Glu Arg Met Asn Gln Asn Ser Asn Ile Cys 
545                 550                 555                 560 


Phe Thr His Gly Gln Lys Asp Cys Leu Glu Cys Phe Pro Val Ser Glu 
                565                 570                 575     


Ser Gln Pro Val Ser Val Val Lys Lys Ala Tyr Gln Lys Leu Cys Tyr 
            580                 585                 590         


Ile His His Ile Met Gly Lys Val Pro Asp Ala Cys Thr Ala Cys Asp 
        595                 600                 605             


Leu Val Asn Val Asp Leu Asp Asp Cys Ile Phe Glu Gln 
    610                 615                 620     


<210>  14
<211>  13
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Y-G/A/R/K-Y/H-GNPA-T/R/H-RYFD-V/K motif


<220>
<221>  MISC_FEATURE
<222>  (2)..(2)
<223>  Xaa is selected from Glycine (G), Alanine (A),  Arginine (R), or 
       Lysine (K)

<220>
<221>  MISC_FEATURE
<222>  (3)..(3)
<223>  Xaa is selected from Tyrosine (Y), or Histidine (H)

<220>
<221>  MISC_FEATURE
<222>  (8)..(8)
<223>  Xaa is selected from Threonine (T), Arginine (R), or Histidine 
       (H)

<220>
<221>  MISC_FEATURE
<222>  (13)..(13)
<223>  Xaa is selected from Valine (V), or Lysine (K)

<400>  14

Tyr Xaa Xaa Gly Asn Pro Ala Xaa Arg Tyr Phe Asp Xaa 
1               5                   10              


<210>  15
<211>  10
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  HYL peptide

<400>  15

His Tyr Leu Gly Tyr Ala Trp Val Gly Gly 
1               5                   10  


<210>  16
<211>  11
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  EFS peptide

<400>  16

Glu Phe Ser Ser Asn Thr Val Lys Leu Thr Ser 
1               5                   10      


<210>  17
<211>  10
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  SAN peptide

<400>  17

Ser Ala Asn Phe Ile Lys Pro Thr Ser Tyr 
1               5                   10  


<210>  18
<211>  4731
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  AAV2/9 n588 YGY2A nucleic acid sequence expression cassette


<220>
<221>  misc_feature
<222>  (1)..(36)
<223>  truncated promoter

<220>
<221>  misc_feature
<222>  (1)..(7)
<223>  p5 promoter

<220>
<221>  CDS
<222>  (37)..(1902)
<223>  AAV2 rep

<220>
<221>  CDS
<222>  (1919)..(4168)
<223>  AAV9-YGY2A Cap

<220>
<221>  misc_feature
<222>  (3683)..(3721)
<223>  YGY2A

<220>
<221>  misc_feature
<222>  (4258)..(4389)
<223>  P5 promoter

<220>
<221>  misc_feature
<222>  (4437)..(4731)
<223>  LacZ promoter

<400>  18
ccattttgaa gcgggaggtt tgaacgcgca gccgcc atg ccg ggg ttt tac gag         54
                                        Met Pro Gly Phe Tyr Glu           
                                        1               5                 

att gtg att aag gtc ccc agc gac ctt gac gag cat ctg ccc ggc att        102
Ile Val Ile Lys Val Pro Ser Asp Leu Asp Glu His Leu Pro Gly Ile           
            10                  15                  20                    

tct gac agc ttt gtg aac tgg gtg gcc gag aag gaa tgg gag ttg ccg        150
Ser Asp Ser Phe Val Asn Trp Val Ala Glu Lys Glu Trp Glu Leu Pro           
        25                  30                  35                        

cca gat tct gac atg gat ctg aat ctg att gag cag gca ccc ctg acc        198
Pro Asp Ser Asp Met Asp Leu Asn Leu Ile Glu Gln Ala Pro Leu Thr           
    40                  45                  50                            

gtg gcc gag aag ctg cag cgc gac ttt ctg acg gaa tgg cgc cgt gtg        246
Val Ala Glu Lys Leu Gln Arg Asp Phe Leu Thr Glu Trp Arg Arg Val           
55                  60                  65                  70            

agt aag gcc ccg gag gct ctt ttc ttt gtg caa ttt gag aag gga gag        294
Ser Lys Ala Pro Glu Ala Leu Phe Phe Val Gln Phe Glu Lys Gly Glu           
                75                  80                  85                

agc tac ttc cac atg cac gtg ctc gtg gaa acc acc ggg gtg aaa tcc        342
Ser Tyr Phe His Met His Val Leu Val Glu Thr Thr Gly Val Lys Ser           
            90                  95                  100                   

atg gtt ttg gga cgt ttc ctg agt cag att cgc gaa aaa ctg att cag        390
Met Val Leu Gly Arg Phe Leu Ser Gln Ile Arg Glu Lys Leu Ile Gln           
        105                 110                 115                       

aga att tac cgc ggg atc gag ccg act ttg cca aac tgg ttc gcg gtc        438
Arg Ile Tyr Arg Gly Ile Glu Pro Thr Leu Pro Asn Trp Phe Ala Val           
    120                 125                 130                           

aca aag acc aga aat ggc gcc gga ggc ggg aac aag gtg gtg gat gag        486
Thr Lys Thr Arg Asn Gly Ala Gly Gly Gly Asn Lys Val Val Asp Glu           
135                 140                 145                 150           

tgc tac atc ccc aat tac ttg ctc ccc aaa acc cag cct gag ctc cag        534
Cys Tyr Ile Pro Asn Tyr Leu Leu Pro Lys Thr Gln Pro Glu Leu Gln           
                155                 160                 165               

tgg gcg tgg act aat atg gaa cag tat tta agc gcc tgt ttg aat ctc        582
Trp Ala Trp Thr Asn Met Glu Gln Tyr Leu Ser Ala Cys Leu Asn Leu           
            170                 175                 180                   

acg gag cgt aaa cgg ttg gtg gcg cag cat ctg acg cac gtg tcg cag        630
Thr Glu Arg Lys Arg Leu Val Ala Gln His Leu Thr His Val Ser Gln           
        185                 190                 195                       

acg cag gag cag aac aaa gag aat cag aat ccc aat tct gat gcg ccg        678
Thr Gln Glu Gln Asn Lys Glu Asn Gln Asn Pro Asn Ser Asp Ala Pro           
    200                 205                 210                           

gtg atc aga tca aaa act tca gcc agg tac atg gag ctg gtc ggg tgg        726
Val Ile Arg Ser Lys Thr Ser Ala Arg Tyr Met Glu Leu Val Gly Trp           
215                 220                 225                 230           

ctc gtg gac aag ggg att acc tcg gag aag cag tgg atc cag gag gac        774
Leu Val Asp Lys Gly Ile Thr Ser Glu Lys Gln Trp Ile Gln Glu Asp           
                235                 240                 245               

cag gcc tca tac atc tcc ttc aat gcg gcc tcc aac tcg cgg tcc caa        822
Gln Ala Ser Tyr Ile Ser Phe Asn Ala Ala Ser Asn Ser Arg Ser Gln           
            250                 255                 260                   

atc aag gct gcc ttg gac aat gcg gga aag att atg agc ctg act aaa        870
Ile Lys Ala Ala Leu Asp Asn Ala Gly Lys Ile Met Ser Leu Thr Lys           
        265                 270                 275                       

acc gcc ccc gac tac ctg gtg ggc cag cag ccc gtg gag gac att tcc        918
Thr Ala Pro Asp Tyr Leu Val Gly Gln Gln Pro Val Glu Asp Ile Ser           
    280                 285                 290                           

agc aat cgg att tat aaa att ttg gaa cta aac ggg tac gat ccc caa        966
Ser Asn Arg Ile Tyr Lys Ile Leu Glu Leu Asn Gly Tyr Asp Pro Gln           
295                 300                 305                 310           

tat gcg gct tcc gtc ttt ctg gga tgg gcc acg aaa aag ttc ggc aag       1014
Tyr Ala Ala Ser Val Phe Leu Gly Trp Ala Thr Lys Lys Phe Gly Lys           
                315                 320                 325               

agg aac acc atc tgg ctg ttt ggg cct gca act acc ggg aag acc aac       1062
Arg Asn Thr Ile Trp Leu Phe Gly Pro Ala Thr Thr Gly Lys Thr Asn           
            330                 335                 340                   

atc gcg gag gcc ata gcc cac act gtg ccc ttc tac ggg tgc gta aac       1110
Ile Ala Glu Ala Ile Ala His Thr Val Pro Phe Tyr Gly Cys Val Asn           
        345                 350                 355                       

tgg acc aat gag aac ttt ccc ttc aac gac tgt gtc gac aag atg gtg       1158
Trp Thr Asn Glu Asn Phe Pro Phe Asn Asp Cys Val Asp Lys Met Val           
    360                 365                 370                           

atc tgg tgg gag gag ggg aag atg acc gcc aag gtc gtg gag tcg gcc       1206
Ile Trp Trp Glu Glu Gly Lys Met Thr Ala Lys Val Val Glu Ser Ala           
375                 380                 385                 390           

aaa gcc att ctc gga gga agc aag gtg cgc gtg gac cag aaa tgc aag       1254
Lys Ala Ile Leu Gly Gly Ser Lys Val Arg Val Asp Gln Lys Cys Lys           
                395                 400                 405               

tcc tcg gcc cag ata gac ccg act ccc gtg atc gtc acc tcc aac acc       1302
Ser Ser Ala Gln Ile Asp Pro Thr Pro Val Ile Val Thr Ser Asn Thr           
            410                 415                 420                   

aac atg tgc gcc gtg att gac ggg aac tca acg acc ttc gaa cac cag       1350
Asn Met Cys Ala Val Ile Asp Gly Asn Ser Thr Thr Phe Glu His Gln           
        425                 430                 435                       

cag ccg ttg caa gac cgg atg ttc aaa ttt gaa ctc acc cgc cgt ctg       1398
Gln Pro Leu Gln Asp Arg Met Phe Lys Phe Glu Leu Thr Arg Arg Leu           
    440                 445                 450                           

gat cat gac ttt ggg aag gtc acc aag cag gaa gtc aaa gac ttt ttc       1446
Asp His Asp Phe Gly Lys Val Thr Lys Gln Glu Val Lys Asp Phe Phe           
455                 460                 465                 470           

cgg tgg gca aag gat cac gtg gtt gag gtg gag cat gaa ttc tac gtc       1494
Arg Trp Ala Lys Asp His Val Val Glu Val Glu His Glu Phe Tyr Val           
                475                 480                 485               

aaa aag ggt gga gcc aag aaa aga ccc gcc ccc agt gac gca gat ata       1542
Lys Lys Gly Gly Ala Lys Lys Arg Pro Ala Pro Ser Asp Ala Asp Ile           
            490                 495                 500                   

agt gag ccc aaa cgg gtg cgc gag tca gtt gcg cag cca tcg acg tca       1590
Ser Glu Pro Lys Arg Val Arg Glu Ser Val Ala Gln Pro Ser Thr Ser           
        505                 510                 515                       

gac gcg gaa gct tcg atc aac tac gca gac agg tac caa aac aaa tgt       1638
Asp Ala Glu Ala Ser Ile Asn Tyr Ala Asp Arg Tyr Gln Asn Lys Cys           
    520                 525                 530                           

tct cgt cac gtg ggc atg aat ctg atg ctg ttt ccc tgc aga caa tgc       1686
Ser Arg His Val Gly Met Asn Leu Met Leu Phe Pro Cys Arg Gln Cys           
535                 540                 545                 550           

gag aga atg aat cag aat tca aat atc tgc ttc act cac gga cag aaa       1734
Glu Arg Met Asn Gln Asn Ser Asn Ile Cys Phe Thr His Gly Gln Lys           
                555                 560                 565               

gac tgt tta gag tgc ttt ccc gtg tca gaa tct caa ccc gtt tct gtc       1782
Asp Cys Leu Glu Cys Phe Pro Val Ser Glu Ser Gln Pro Val Ser Val           
            570                 575                 580                   

gtc aaa aag gcg tat cag aaa ctg tgc tac att cat cat atc atg gga       1830
Val Lys Lys Ala Tyr Gln Lys Leu Cys Tyr Ile His His Ile Met Gly           
        585                 590                 595                       

aag gtg cca gac gct tgc act gcc tgc gat ctg gtc aat gtg gat ttg       1878
Lys Val Pro Asp Ala Cys Thr Ala Cys Asp Leu Val Asn Val Asp Leu           
    600                 605                 610                           

gat gac tgc atc ttt gaa caa taa atgatttaaa tcaggt atg gct gcc gat     1930
Asp Asp Cys Ile Phe Glu Gln                       Met Ala Ala Asp         
615                 620                                       625         

ggt tat ctt cca gat tgg ctc gag gac aac ctt agt gaa gga att cgc       1978
Gly Tyr Leu Pro Asp Trp Leu Glu Asp Asn Leu Ser Glu Gly Ile Arg           
                630                 635                 640               

gag tgg tgg gct ttg aaa cct gga gcc cct caa ccc aag gca aat caa       2026
Glu Trp Trp Ala Leu Lys Pro Gly Ala Pro Gln Pro Lys Ala Asn Gln           
            645                 650                 655                   

caa cat caa gac aac gct cga ggt ctt gtg ctt ccg ggt tac aaa tac       2074
Gln His Gln Asp Asn Ala Arg Gly Leu Val Leu Pro Gly Tyr Lys Tyr           
        660                 665                 670                       

ctt gga ccc ggc aac gga ctc gac aag ggg gag ccg gtc aac gca gca       2122
Leu Gly Pro Gly Asn Gly Leu Asp Lys Gly Glu Pro Val Asn Ala Ala           
    675                 680                 685                           

gac gcg gcg gcc ctc gag cac gac aag gcc tac gac cag cag ctc aag       2170
Asp Ala Ala Ala Leu Glu His Asp Lys Ala Tyr Asp Gln Gln Leu Lys           
690                 695                 700                 705           

gcc gga gac aac ccg tac ctc aag tac aac cac gcc gac gcc gag ttc       2218
Ala Gly Asp Asn Pro Tyr Leu Lys Tyr Asn His Ala Asp Ala Glu Phe           
                710                 715                 720               

cag gag cgg ctc aaa gaa gat acg tct ttt ggg ggc aac ctc ggg cga       2266
Gln Glu Arg Leu Lys Glu Asp Thr Ser Phe Gly Gly Asn Leu Gly Arg           
            725                 730                 735                   

gca gtc ttc cag gcc aaa aag agg ctt ctt gaa cct ctt ggt ctg gtt       2314
Ala Val Phe Gln Ala Lys Lys Arg Leu Leu Glu Pro Leu Gly Leu Val           
        740                 745                 750                       

gag gaa gcg gct aag acg gct cct gga aag aag agg cct gta gag cag       2362
Glu Glu Ala Ala Lys Thr Ala Pro Gly Lys Lys Arg Pro Val Glu Gln           
    755                 760                 765                           

tct cct cag gaa ccg gac tcc tcc gcg ggt att ggc aaa tcg ggt gca       2410
Ser Pro Gln Glu Pro Asp Ser Ser Ala Gly Ile Gly Lys Ser Gly Ala           
770                 775                 780                 785           

cag ccc gct aaa aag aga ctc aat ttc ggt cag act ggc gac aca gag       2458
Gln Pro Ala Lys Lys Arg Leu Asn Phe Gly Gln Thr Gly Asp Thr Glu           
                790                 795                 800               

tca gtc cca gac cct caa cca atc gga gaa cct ccc gca gcc ccc tca       2506
Ser Val Pro Asp Pro Gln Pro Ile Gly Glu Pro Pro Ala Ala Pro Ser           
            805                 810                 815                   

ggt gtg gga tct ctt aca atg gct tca ggt ggt ggc gca cca gtg gca       2554
Gly Val Gly Ser Leu Thr Met Ala Ser Gly Gly Gly Ala Pro Val Ala           
        820                 825                 830                       

gac aat aac gaa ggt gcc gat gga gtg ggt agt tcc tcg gga aat tgg       2602
Asp Asn Asn Glu Gly Ala Asp Gly Val Gly Ser Ser Ser Gly Asn Trp           
    835                 840                 845                           

cat tgc gat tcc caa tgg ctg ggg gac aga gtc atc acc acc agc acc       2650
His Cys Asp Ser Gln Trp Leu Gly Asp Arg Val Ile Thr Thr Ser Thr           
850                 855                 860                 865           

cga acc tgg gcc ctg ccc acc tac aac aat cac ctc tac aag caa atc       2698
Arg Thr Trp Ala Leu Pro Thr Tyr Asn Asn His Leu Tyr Lys Gln Ile           
                870                 875                 880               

tcc aac agc aca tct gga gga tct tca aat gac aac gcc tac ttc ggc       2746
Ser Asn Ser Thr Ser Gly Gly Ser Ser Asn Asp Asn Ala Tyr Phe Gly           
            885                 890                 895                   

tac agc acc ccc tgg ggg tat ttt gac ttc aac aga ttc cac tgc cac       2794
Tyr Ser Thr Pro Trp Gly Tyr Phe Asp Phe Asn Arg Phe His Cys His           
        900                 905                 910                       

ttc tca cca cgt gac tgg cag cga ctc atc aac aac aac tgg gga ttc       2842
Phe Ser Pro Arg Asp Trp Gln Arg Leu Ile Asn Asn Asn Trp Gly Phe           
    915                 920                 925                           

cgg cct aag cga ctc aac ttc aag ctc ttc aac att cag gtc aaa gag       2890
Arg Pro Lys Arg Leu Asn Phe Lys Leu Phe Asn Ile Gln Val Lys Glu           
930                 935                 940                 945           

gtt acg gac aac aat gga gtc aag acc atc gcc aat aac ctt acc agc       2938
Val Thr Asp Asn Asn Gly Val Lys Thr Ile Ala Asn Asn Leu Thr Ser           
                950                 955                 960               

acg gtc cag gtc ttc acg gac tca gac tat cag ctc ccg tac gtg ctc       2986
Thr Val Gln Val Phe Thr Asp Ser Asp Tyr Gln Leu Pro Tyr Val Leu           
            965                 970                 975                   

ggg tcg gct cac gag ggc tgc ctc ccg ccg ttc cca gcg gac gtt ttc       3034
Gly Ser Ala His Glu Gly Cys Leu Pro Pro Phe Pro Ala Asp Val Phe           
        980                 985                 990                       

atg att cct cag tac ggg tat  ctg acg ctt aat gat  gga agc cag gcc     3082
Met Ile Pro Gln Tyr Gly Tyr  Leu Thr Leu Asn Asp  Gly Ser Gln Ala         
    995                 1000                 1005                         

gtg  ggt cgt tcg tcc ttt  tac tgc ctg gaa tat  ttc ccg tcg caa        3127
Val  Gly Arg Ser Ser Phe  Tyr Cys Leu Glu Tyr  Phe Pro Ser Gln            
1010                 1015                 1020                            

atg  cta aga acg ggt aac  aac ttc cag ttc agc  tac gag ttt gag        3172
Met  Leu Arg Thr Gly Asn  Asn Phe Gln Phe Ser  Tyr Glu Phe Glu            
1025                 1030                 1035                            

aac  gta cct ttc cat agc  agc tac gct cac agc  caa agc ctg gac        3217
Asn  Val Pro Phe His Ser  Ser Tyr Ala His Ser  Gln Ser Leu Asp            
1040                 1045                 1050                            

cga  cta atg aat cca ctc  atc gac caa tac ttg  tac tat ctc tca        3262
Arg  Leu Met Asn Pro Leu  Ile Asp Gln Tyr Leu  Tyr Tyr Leu Ser            
1055                 1060                 1065                            

aag  act att aac ggt tct  gga cag aat caa caa  acg cta aaa ttc        3307
Lys  Thr Ile Asn Gly Ser  Gly Gln Asn Gln Gln  Thr Leu Lys Phe            
1070                 1075                 1080                            

agt  gtg gcc gga ccc agc  aac atg gct gtc cag  gga aga aac tac        3352
Ser  Val Ala Gly Pro Ser  Asn Met Ala Val Gln  Gly Arg Asn Tyr            
1085                 1090                 1095                            

ata  cct gga ccc agc tac  cga caa caa cgt gtc  tca acc act gtg        3397
Ile  Pro Gly Pro Ser Tyr  Arg Gln Gln Arg Val  Ser Thr Thr Val            
1100                 1105                 1110                            

act  caa aac aac aac agc  gaa ttt gct tgg cct  gga gct tct tct        3442
Thr  Gln Asn Asn Asn Ser  Glu Phe Ala Trp Pro  Gly Ala Ser Ser            
1115                 1120                 1125                            

tgg  gct ctc aat gga cgt  aat agc ttg atg aat  cct gga cct gct        3487
Trp  Ala Leu Asn Gly Arg  Asn Ser Leu Met Asn  Pro Gly Pro Ala            
1130                 1135                 1140                            

atg  gcc agc cac aaa gaa  gga gag gac cgt ttc  ttt cct ttg tct        3532
Met  Ala Ser His Lys Glu  Gly Glu Asp Arg Phe  Phe Pro Leu Ser            
1145                 1150                 1155                            

gga  tct tta att ttt ggc  aaa caa gga act gga  aga gac aac gtg        3577
Gly  Ser Leu Ile Phe Gly  Lys Gln Gly Thr Gly  Arg Asp Asn Val            
1160                 1165                 1170                            

gat  gcg gac aaa gtc atg  ata acc aac gaa gaa  gaa att aaa act        3622
Asp  Ala Asp Lys Val Met  Ile Thr Asn Glu Glu  Glu Ile Lys Thr            
1175                 1180                 1185                            

act  aac ccg gta gca acg  gag tcc tat gga caa  gtg gcc aca aac        3667
Thr  Asn Pro Val Ala Thr  Glu Ser Tyr Gly Gln  Val Ala Thr Asn            
1190                 1195                 1200                            

cac  cag agt gcc caa tat  gcg tat ggc aac ccg  gcg acc cgt tat        3712
His  Gln Ser Ala Gln Tyr  Ala Tyr Gly Asn Pro  Ala Thr Arg Tyr            
1205                 1210                 1215                            

ttt  gat gtg gca cag gcg  cag acc ggc tgg gtt  caa aac caa gga        3757
Phe  Asp Val Ala Gln Ala  Gln Thr Gly Trp Val  Gln Asn Gln Gly            
1220                 1225                 1230                            

ata  ctt ccg ggt atg gtt  tgg cag gac aga gat  gtg tac ctg caa        3802
Ile  Leu Pro Gly Met Val  Trp Gln Asp Arg Asp  Val Tyr Leu Gln            
1235                 1240                 1245                            

gga  ccc att tgg gcc aaa  att cct cac acg gac  ggc aac ttt cac        3847
Gly  Pro Ile Trp Ala Lys  Ile Pro His Thr Asp  Gly Asn Phe His            
1250                 1255                 1260                            

cct  tct ccg ctg atg gga  ggg ttt gga atg aag  cac ccg cct cct        3892
Pro  Ser Pro Leu Met Gly  Gly Phe Gly Met Lys  His Pro Pro Pro            
1265                 1270                 1275                            

cag  atc ctc atc aaa aac  aca cct gta cct gcg  gat cct cca acg        3937
Gln  Ile Leu Ile Lys Asn  Thr Pro Val Pro Ala  Asp Pro Pro Thr            
1280                 1285                 1290                            

gcc  ttc aac aag gac aag  ctg aac tct ttc atc  acc cag tat tct        3982
Ala  Phe Asn Lys Asp Lys  Leu Asn Ser Phe Ile  Thr Gln Tyr Ser            
1295                 1300                 1305                            

act  ggc caa gtc agc gtg  gag atc gag tgg gag  ctg cag aag gaa        4027
Thr  Gly Gln Val Ser Val  Glu Ile Glu Trp Glu  Leu Gln Lys Glu            
1310                 1315                 1320                            

aac  agc aag cgc tgg aac  ccg gag atc cag tac  act tcc aac tat        4072
Asn  Ser Lys Arg Trp Asn  Pro Glu Ile Gln Tyr  Thr Ser Asn Tyr            
1325                 1330                 1335                            

tac  aag tct aat aat gtt  gaa ttt gct gtt aat  act gaa ggt gta        4117
Tyr  Lys Ser Asn Asn Val  Glu Phe Ala Val Asn  Thr Glu Gly Val            
1340                 1345                 1350                            

tat  agt gaa ccc cgc ccc  att ggc acc aga tac  ctg act cgt aat        4162
Tyr  Ser Glu Pro Arg Pro  Ile Gly Thr Arg Tyr  Leu Thr Arg Asn            
1355                 1360                 1365                            

ctg  taa ttgcttgtta atcaataaac cgtttaattc gtttcagttg aactttggtc       4218
Leu                                                                       
1370                                                                      

tctgcgaagg gcgaattcgt ttaaacctgc aggactagag gtcctgtatt agaggtcacg     4278

tgagtgtttt gcgacatttt gcgacaccat gtggtcacgc tgggtattta agcccgagtg     4338

agcacgcagg gtctccattt tgaagcggga ggtttgaacg cgcagccgcc aagccgaatt     4398

ctgcagatat ccatcacact ggcggccgct cgactagagc ggccgccacc gcggtggagc     4458

tccagctttt gttcccttta gtgagggtta attgcgcgct tggcgtaatc atggtcatag     4518

ctgtttcctg tgtgaaattg ttatccgctc acaattccac acaacatacg agccggaagc     4578

ataaagtgta aagcctgggg tgcctaatga gtgagctaac tcacattaat tgcgttgcgc     4638

tcactgcccg ctttccagtc gggaaacctg tcgtgccagc tgcattaatg aatcggccaa     4698

cgcgcgggga gaggcggttt gcgtattggg cgc                                  4731


<210>  19
<211>  621
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic Construct

<400>  19

Met Pro Gly Phe Tyr Glu Ile Val Ile Lys Val Pro Ser Asp Leu Asp 
1               5                   10                  15      


Glu His Leu Pro Gly Ile Ser Asp Ser Phe Val Asn Trp Val Ala Glu 
            20                  25                  30          


Lys Glu Trp Glu Leu Pro Pro Asp Ser Asp Met Asp Leu Asn Leu Ile 
        35                  40                  45              


Glu Gln Ala Pro Leu Thr Val Ala Glu Lys Leu Gln Arg Asp Phe Leu 
    50                  55                  60                  


Thr Glu Trp Arg Arg Val Ser Lys Ala Pro Glu Ala Leu Phe Phe Val 
65                  70                  75                  80  


Gln Phe Glu Lys Gly Glu Ser Tyr Phe His Met His Val Leu Val Glu 
                85                  90                  95      


Thr Thr Gly Val Lys Ser Met Val Leu Gly Arg Phe Leu Ser Gln Ile 
            100                 105                 110         


Arg Glu Lys Leu Ile Gln Arg Ile Tyr Arg Gly Ile Glu Pro Thr Leu 
        115                 120                 125             


Pro Asn Trp Phe Ala Val Thr Lys Thr Arg Asn Gly Ala Gly Gly Gly 
    130                 135                 140                 


Asn Lys Val Val Asp Glu Cys Tyr Ile Pro Asn Tyr Leu Leu Pro Lys 
145                 150                 155                 160 


Thr Gln Pro Glu Leu Gln Trp Ala Trp Thr Asn Met Glu Gln Tyr Leu 
                165                 170                 175     


Ser Ala Cys Leu Asn Leu Thr Glu Arg Lys Arg Leu Val Ala Gln His 
            180                 185                 190         


Leu Thr His Val Ser Gln Thr Gln Glu Gln Asn Lys Glu Asn Gln Asn 
        195                 200                 205             


Pro Asn Ser Asp Ala Pro Val Ile Arg Ser Lys Thr Ser Ala Arg Tyr 
    210                 215                 220                 


Met Glu Leu Val Gly Trp Leu Val Asp Lys Gly Ile Thr Ser Glu Lys 
225                 230                 235                 240 


Gln Trp Ile Gln Glu Asp Gln Ala Ser Tyr Ile Ser Phe Asn Ala Ala 
                245                 250                 255     


Ser Asn Ser Arg Ser Gln Ile Lys Ala Ala Leu Asp Asn Ala Gly Lys 
            260                 265                 270         


Ile Met Ser Leu Thr Lys Thr Ala Pro Asp Tyr Leu Val Gly Gln Gln 
        275                 280                 285             


Pro Val Glu Asp Ile Ser Ser Asn Arg Ile Tyr Lys Ile Leu Glu Leu 
    290                 295                 300                 


Asn Gly Tyr Asp Pro Gln Tyr Ala Ala Ser Val Phe Leu Gly Trp Ala 
305                 310                 315                 320 


Thr Lys Lys Phe Gly Lys Arg Asn Thr Ile Trp Leu Phe Gly Pro Ala 
                325                 330                 335     


Thr Thr Gly Lys Thr Asn Ile Ala Glu Ala Ile Ala His Thr Val Pro 
            340                 345                 350         


Phe Tyr Gly Cys Val Asn Trp Thr Asn Glu Asn Phe Pro Phe Asn Asp 
        355                 360                 365             


Cys Val Asp Lys Met Val Ile Trp Trp Glu Glu Gly Lys Met Thr Ala 
    370                 375                 380                 


Lys Val Val Glu Ser Ala Lys Ala Ile Leu Gly Gly Ser Lys Val Arg 
385                 390                 395                 400 


Val Asp Gln Lys Cys Lys Ser Ser Ala Gln Ile Asp Pro Thr Pro Val 
                405                 410                 415     


Ile Val Thr Ser Asn Thr Asn Met Cys Ala Val Ile Asp Gly Asn Ser 
            420                 425                 430         


Thr Thr Phe Glu His Gln Gln Pro Leu Gln Asp Arg Met Phe Lys Phe 
        435                 440                 445             


Glu Leu Thr Arg Arg Leu Asp His Asp Phe Gly Lys Val Thr Lys Gln 
    450                 455                 460                 


Glu Val Lys Asp Phe Phe Arg Trp Ala Lys Asp His Val Val Glu Val 
465                 470                 475                 480 


Glu His Glu Phe Tyr Val Lys Lys Gly Gly Ala Lys Lys Arg Pro Ala 
                485                 490                 495     


Pro Ser Asp Ala Asp Ile Ser Glu Pro Lys Arg Val Arg Glu Ser Val 
            500                 505                 510         


Ala Gln Pro Ser Thr Ser Asp Ala Glu Ala Ser Ile Asn Tyr Ala Asp 
        515                 520                 525             


Arg Tyr Gln Asn Lys Cys Ser Arg His Val Gly Met Asn Leu Met Leu 
    530                 535                 540                 


Phe Pro Cys Arg Gln Cys Glu Arg Met Asn Gln Asn Ser Asn Ile Cys 
545                 550                 555                 560 


Phe Thr His Gly Gln Lys Asp Cys Leu Glu Cys Phe Pro Val Ser Glu 
                565                 570                 575     


Ser Gln Pro Val Ser Val Val Lys Lys Ala Tyr Gln Lys Leu Cys Tyr 
            580                 585                 590         


Ile His His Ile Met Gly Lys Val Pro Asp Ala Cys Thr Ala Cys Asp 
        595                 600                 605             


Leu Val Asn Val Asp Leu Asp Asp Cys Ile Phe Glu Gln 
    610                 615                 620     


<210>  20
<211>  749
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic Construct

<400>  20

Met Ala Ala Asp Gly Tyr Leu Pro Asp Trp Leu Glu Asp Asn Leu Ser 
1               5                   10                  15      


Glu Gly Ile Arg Glu Trp Trp Ala Leu Lys Pro Gly Ala Pro Gln Pro 
            20                  25                  30          


Lys Ala Asn Gln Gln His Gln Asp Asn Ala Arg Gly Leu Val Leu Pro 
        35                  40                  45              


Gly Tyr Lys Tyr Leu Gly Pro Gly Asn Gly Leu Asp Lys Gly Glu Pro 
    50                  55                  60                  


Val Asn Ala Ala Asp Ala Ala Ala Leu Glu His Asp Lys Ala Tyr Asp 
65                  70                  75                  80  


Gln Gln Leu Lys Ala Gly Asp Asn Pro Tyr Leu Lys Tyr Asn His Ala 
                85                  90                  95      


Asp Ala Glu Phe Gln Glu Arg Leu Lys Glu Asp Thr Ser Phe Gly Gly 
            100                 105                 110         


Asn Leu Gly Arg Ala Val Phe Gln Ala Lys Lys Arg Leu Leu Glu Pro 
        115                 120                 125             


Leu Gly Leu Val Glu Glu Ala Ala Lys Thr Ala Pro Gly Lys Lys Arg 
    130                 135                 140                 


Pro Val Glu Gln Ser Pro Gln Glu Pro Asp Ser Ser Ala Gly Ile Gly 
145                 150                 155                 160 


Lys Ser Gly Ala Gln Pro Ala Lys Lys Arg Leu Asn Phe Gly Gln Thr 
                165                 170                 175     


Gly Asp Thr Glu Ser Val Pro Asp Pro Gln Pro Ile Gly Glu Pro Pro 
            180                 185                 190         


Ala Ala Pro Ser Gly Val Gly Ser Leu Thr Met Ala Ser Gly Gly Gly 
        195                 200                 205             


Ala Pro Val Ala Asp Asn Asn Glu Gly Ala Asp Gly Val Gly Ser Ser 
    210                 215                 220                 


Ser Gly Asn Trp His Cys Asp Ser Gln Trp Leu Gly Asp Arg Val Ile 
225                 230                 235                 240 


Thr Thr Ser Thr Arg Thr Trp Ala Leu Pro Thr Tyr Asn Asn His Leu 
                245                 250                 255     


Tyr Lys Gln Ile Ser Asn Ser Thr Ser Gly Gly Ser Ser Asn Asp Asn 
            260                 265                 270         


Ala Tyr Phe Gly Tyr Ser Thr Pro Trp Gly Tyr Phe Asp Phe Asn Arg 
        275                 280                 285             


Phe His Cys His Phe Ser Pro Arg Asp Trp Gln Arg Leu Ile Asn Asn 
    290                 295                 300                 


Asn Trp Gly Phe Arg Pro Lys Arg Leu Asn Phe Lys Leu Phe Asn Ile 
305                 310                 315                 320 


Gln Val Lys Glu Val Thr Asp Asn Asn Gly Val Lys Thr Ile Ala Asn 
                325                 330                 335     


Asn Leu Thr Ser Thr Val Gln Val Phe Thr Asp Ser Asp Tyr Gln Leu 
            340                 345                 350         


Pro Tyr Val Leu Gly Ser Ala His Glu Gly Cys Leu Pro Pro Phe Pro 
        355                 360                 365             


Ala Asp Val Phe Met Ile Pro Gln Tyr Gly Tyr Leu Thr Leu Asn Asp 
    370                 375                 380                 


Gly Ser Gln Ala Val Gly Arg Ser Ser Phe Tyr Cys Leu Glu Tyr Phe 
385                 390                 395                 400 


Pro Ser Gln Met Leu Arg Thr Gly Asn Asn Phe Gln Phe Ser Tyr Glu 
                405                 410                 415     


Phe Glu Asn Val Pro Phe His Ser Ser Tyr Ala His Ser Gln Ser Leu 
            420                 425                 430         


Asp Arg Leu Met Asn Pro Leu Ile Asp Gln Tyr Leu Tyr Tyr Leu Ser 
        435                 440                 445             


Lys Thr Ile Asn Gly Ser Gly Gln Asn Gln Gln Thr Leu Lys Phe Ser 
    450                 455                 460                 


Val Ala Gly Pro Ser Asn Met Ala Val Gln Gly Arg Asn Tyr Ile Pro 
465                 470                 475                 480 


Gly Pro Ser Tyr Arg Gln Gln Arg Val Ser Thr Thr Val Thr Gln Asn 
                485                 490                 495     


Asn Asn Ser Glu Phe Ala Trp Pro Gly Ala Ser Ser Trp Ala Leu Asn 
            500                 505                 510         


Gly Arg Asn Ser Leu Met Asn Pro Gly Pro Ala Met Ala Ser His Lys 
        515                 520                 525             


Glu Gly Glu Asp Arg Phe Phe Pro Leu Ser Gly Ser Leu Ile Phe Gly 
    530                 535                 540                 


Lys Gln Gly Thr Gly Arg Asp Asn Val Asp Ala Asp Lys Val Met Ile 
545                 550                 555                 560 


Thr Asn Glu Glu Glu Ile Lys Thr Thr Asn Pro Val Ala Thr Glu Ser 
                565                 570                 575     


Tyr Gly Gln Val Ala Thr Asn His Gln Ser Ala Gln Tyr Ala Tyr Gly 
            580                 585                 590         


Asn Pro Ala Thr Arg Tyr Phe Asp Val Ala Gln Ala Gln Thr Gly Trp 
        595                 600                 605             


Val Gln Asn Gln Gly Ile Leu Pro Gly Met Val Trp Gln Asp Arg Asp 
    610                 615                 620                 


Val Tyr Leu Gln Gly Pro Ile Trp Ala Lys Ile Pro His Thr Asp Gly 
625                 630                 635                 640 


Asn Phe His Pro Ser Pro Leu Met Gly Gly Phe Gly Met Lys His Pro 
                645                 650                 655     


Pro Pro Gln Ile Leu Ile Lys Asn Thr Pro Val Pro Ala Asp Pro Pro 
            660                 665                 670         


Thr Ala Phe Asn Lys Asp Lys Leu Asn Ser Phe Ile Thr Gln Tyr Ser 
        675                 680                 685             


Thr Gly Gln Val Ser Val Glu Ile Glu Trp Glu Leu Gln Lys Glu Asn 
    690                 695                 700                 


Ser Lys Arg Trp Asn Pro Glu Ile Gln Tyr Thr Ser Asn Tyr Tyr Lys 
705                 710                 715                 720 


Ser Asn Asn Val Glu Phe Ala Val Asn Thr Glu Gly Val Tyr Ser Glu 
                725                 730                 735     


Pro Arg Pro Ile Gly Thr Arg Tyr Leu Thr Arg Asn Leu 
            740                 745                 


<210>  21
<211>  4731
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  AAV2/9 n588 YGY nucleic acid sequence expression cassette


<220>
<221>  misc_feature
<222>  (1)..(36)
<223>  truncated promoter

<220>
<221>  misc_feature
<222>  (1)..(7)
<223>  p5 promoter

<220>
<221>  CDS
<222>  (37)..(1902)
<223>  AAV2 rep

<220>
<221>  CDS
<222>  (1919)..(4168)
<223>  AAV9-YGY cap

<220>
<221>  misc_feature
<222>  (3683)..(3721)
<223>  YGY

<220>
<221>  misc_feature
<222>  (4259)..(4389)
<223>  P5 promoter

<220>
<221>  misc_feature
<222>  (4517)..(4731)
<223>  LacZ promoter

<400>  21
ccattttgaa gcgggaggtt tgaacgcgca gccgcc atg ccg ggg ttt tac gag         54
                                        Met Pro Gly Phe Tyr Glu           
                                        1               5                 

att gtg att aag gtc ccc agc gac ctt gac gag cat ctg ccc ggc att        102
Ile Val Ile Lys Val Pro Ser Asp Leu Asp Glu His Leu Pro Gly Ile           
            10                  15                  20                    

tct gac agc ttt gtg aac tgg gtg gcc gag aag gaa tgg gag ttg ccg        150
Ser Asp Ser Phe Val Asn Trp Val Ala Glu Lys Glu Trp Glu Leu Pro           
        25                  30                  35                        

cca gat tct gac atg gat ctg aat ctg att gag cag gca ccc ctg acc        198
Pro Asp Ser Asp Met Asp Leu Asn Leu Ile Glu Gln Ala Pro Leu Thr           
    40                  45                  50                            

gtg gcc gag aag ctg cag cgc gac ttt ctg acg gaa tgg cgc cgt gtg        246
Val Ala Glu Lys Leu Gln Arg Asp Phe Leu Thr Glu Trp Arg Arg Val           
55                  60                  65                  70            

agt aag gcc ccg gag gct ctt ttc ttt gtg caa ttt gag aag gga gag        294
Ser Lys Ala Pro Glu Ala Leu Phe Phe Val Gln Phe Glu Lys Gly Glu           
                75                  80                  85                

agc tac ttc cac atg cac gtg ctc gtg gaa acc acc ggg gtg aaa tcc        342
Ser Tyr Phe His Met His Val Leu Val Glu Thr Thr Gly Val Lys Ser           
            90                  95                  100                   

atg gtt ttg gga cgt ttc ctg agt cag att cgc gaa aaa ctg att cag        390
Met Val Leu Gly Arg Phe Leu Ser Gln Ile Arg Glu Lys Leu Ile Gln           
        105                 110                 115                       

aga att tac cgc ggg atc gag ccg act ttg cca aac tgg ttc gcg gtc        438
Arg Ile Tyr Arg Gly Ile Glu Pro Thr Leu Pro Asn Trp Phe Ala Val           
    120                 125                 130                           

aca aag acc aga aat ggc gcc gga ggc ggg aac aag gtg gtg gat gag        486
Thr Lys Thr Arg Asn Gly Ala Gly Gly Gly Asn Lys Val Val Asp Glu           
135                 140                 145                 150           

tgc tac atc ccc aat tac ttg ctc ccc aaa acc cag cct gag ctc cag        534
Cys Tyr Ile Pro Asn Tyr Leu Leu Pro Lys Thr Gln Pro Glu Leu Gln           
                155                 160                 165               

tgg gcg tgg act aat atg gaa cag tat tta agc gcc tgt ttg aat ctc        582
Trp Ala Trp Thr Asn Met Glu Gln Tyr Leu Ser Ala Cys Leu Asn Leu           
            170                 175                 180                   

acg gag cgt aaa cgg ttg gtg gcg cag cat ctg acg cac gtg tcg cag        630
Thr Glu Arg Lys Arg Leu Val Ala Gln His Leu Thr His Val Ser Gln           
        185                 190                 195                       

acg cag gag cag aac aaa gag aat cag aat ccc aat tct gat gcg ccg        678
Thr Gln Glu Gln Asn Lys Glu Asn Gln Asn Pro Asn Ser Asp Ala Pro           
    200                 205                 210                           

gtg atc aga tca aaa act tca gcc agg tac atg gag ctg gtc ggg tgg        726
Val Ile Arg Ser Lys Thr Ser Ala Arg Tyr Met Glu Leu Val Gly Trp           
215                 220                 225                 230           

ctc gtg gac aag ggg att acc tcg gag aag cag tgg atc cag gag gac        774
Leu Val Asp Lys Gly Ile Thr Ser Glu Lys Gln Trp Ile Gln Glu Asp           
                235                 240                 245               

cag gcc tca tac atc tcc ttc aat gcg gcc tcc aac tcg cgg tcc caa        822
Gln Ala Ser Tyr Ile Ser Phe Asn Ala Ala Ser Asn Ser Arg Ser Gln           
            250                 255                 260                   

atc aag gct gcc ttg gac aat gcg gga aag att atg agc ctg act aaa        870
Ile Lys Ala Ala Leu Asp Asn Ala Gly Lys Ile Met Ser Leu Thr Lys           
        265                 270                 275                       

acc gcc ccc gac tac ctg gtg ggc cag cag ccc gtg gag gac att tcc        918
Thr Ala Pro Asp Tyr Leu Val Gly Gln Gln Pro Val Glu Asp Ile Ser           
    280                 285                 290                           

agc aat cgg att tat aaa att ttg gaa cta aac ggg tac gat ccc caa        966
Ser Asn Arg Ile Tyr Lys Ile Leu Glu Leu Asn Gly Tyr Asp Pro Gln           
295                 300                 305                 310           

tat gcg gct tcc gtc ttt ctg gga tgg gcc acg aaa aag ttc ggc aag       1014
Tyr Ala Ala Ser Val Phe Leu Gly Trp Ala Thr Lys Lys Phe Gly Lys           
                315                 320                 325               

agg aac acc atc tgg ctg ttt ggg cct gca act acc ggg aag acc aac       1062
Arg Asn Thr Ile Trp Leu Phe Gly Pro Ala Thr Thr Gly Lys Thr Asn           
            330                 335                 340                   

atc gcg gag gcc ata gcc cac act gtg ccc ttc tac ggg tgc gta aac       1110
Ile Ala Glu Ala Ile Ala His Thr Val Pro Phe Tyr Gly Cys Val Asn           
        345                 350                 355                       

tgg acc aat gag aac ttt ccc ttc aac gac tgt gtc gac aag atg gtg       1158
Trp Thr Asn Glu Asn Phe Pro Phe Asn Asp Cys Val Asp Lys Met Val           
    360                 365                 370                           

atc tgg tgg gag gag ggg aag atg acc gcc aag gtc gtg gag tcg gcc       1206
Ile Trp Trp Glu Glu Gly Lys Met Thr Ala Lys Val Val Glu Ser Ala           
375                 380                 385                 390           

aaa gcc att ctc gga gga agc aag gtg cgc gtg gac cag aaa tgc aag       1254
Lys Ala Ile Leu Gly Gly Ser Lys Val Arg Val Asp Gln Lys Cys Lys           
                395                 400                 405               

tcc tcg gcc cag ata gac ccg act ccc gtg atc gtc acc tcc aac acc       1302
Ser Ser Ala Gln Ile Asp Pro Thr Pro Val Ile Val Thr Ser Asn Thr           
            410                 415                 420                   

aac atg tgc gcc gtg att gac ggg aac tca acg acc ttc gaa cac cag       1350
Asn Met Cys Ala Val Ile Asp Gly Asn Ser Thr Thr Phe Glu His Gln           
        425                 430                 435                       

cag ccg ttg caa gac cgg atg ttc aaa ttt gaa ctc acc cgc cgt ctg       1398
Gln Pro Leu Gln Asp Arg Met Phe Lys Phe Glu Leu Thr Arg Arg Leu           
    440                 445                 450                           

gat cat gac ttt ggg aag gtc acc aag cag gaa gtc aaa gac ttt ttc       1446
Asp His Asp Phe Gly Lys Val Thr Lys Gln Glu Val Lys Asp Phe Phe           
455                 460                 465                 470           

cgg tgg gca aag gat cac gtg gtt gag gtg gag cat gaa ttc tac gtc       1494
Arg Trp Ala Lys Asp His Val Val Glu Val Glu His Glu Phe Tyr Val           
                475                 480                 485               

aaa aag ggt gga gcc aag aaa aga ccc gcc ccc agt gac gca gat ata       1542
Lys Lys Gly Gly Ala Lys Lys Arg Pro Ala Pro Ser Asp Ala Asp Ile           
            490                 495                 500                   

agt gag ccc aaa cgg gtg cgc gag tca gtt gcg cag cca tcg acg tca       1590
Ser Glu Pro Lys Arg Val Arg Glu Ser Val Ala Gln Pro Ser Thr Ser           
        505                 510                 515                       

gac gcg gaa gct tcg atc aac tac gca gac agg tac caa aac aaa tgt       1638
Asp Ala Glu Ala Ser Ile Asn Tyr Ala Asp Arg Tyr Gln Asn Lys Cys           
    520                 525                 530                           

tct cgt cac gtg ggc atg aat ctg atg ctg ttt ccc tgc aga caa tgc       1686
Ser Arg His Val Gly Met Asn Leu Met Leu Phe Pro Cys Arg Gln Cys           
535                 540                 545                 550           

gag aga atg aat cag aat tca aat atc tgc ttc act cac gga cag aaa       1734
Glu Arg Met Asn Gln Asn Ser Asn Ile Cys Phe Thr His Gly Gln Lys           
                555                 560                 565               

gac tgt tta gag tgc ttt ccc gtg tca gaa tct caa ccc gtt tct gtc       1782
Asp Cys Leu Glu Cys Phe Pro Val Ser Glu Ser Gln Pro Val Ser Val           
            570                 575                 580                   

gtc aaa aag gcg tat cag aaa ctg tgc tac att cat cat atc atg gga       1830
Val Lys Lys Ala Tyr Gln Lys Leu Cys Tyr Ile His His Ile Met Gly           
        585                 590                 595                       

aag gtg cca gac gct tgc act gcc tgc gat ctg gtc aat gtg gat ttg       1878
Lys Val Pro Asp Ala Cys Thr Ala Cys Asp Leu Val Asn Val Asp Leu           
    600                 605                 610                           

gat gac tgc atc ttt gaa caa taa atgatttaaa tcaggt atg gct gcc gat     1930
Asp Asp Cys Ile Phe Glu Gln                       Met Ala Ala Asp         
615                 620                                       625         

ggt tat ctt cca gat tgg ctc gag gac aac ctt agt gaa gga att cgc       1978
Gly Tyr Leu Pro Asp Trp Leu Glu Asp Asn Leu Ser Glu Gly Ile Arg           
                630                 635                 640               

gag tgg tgg gct ttg aaa cct gga gcc cct caa ccc aag gca aat caa       2026
Glu Trp Trp Ala Leu Lys Pro Gly Ala Pro Gln Pro Lys Ala Asn Gln           
            645                 650                 655                   

caa cat caa gac aac gct cga ggt ctt gtg ctt ccg ggt tac aaa tac       2074
Gln His Gln Asp Asn Ala Arg Gly Leu Val Leu Pro Gly Tyr Lys Tyr           
        660                 665                 670                       

ctt gga ccc ggc aac gga ctc gac aag ggg gag ccg gtc aac gca gca       2122
Leu Gly Pro Gly Asn Gly Leu Asp Lys Gly Glu Pro Val Asn Ala Ala           
    675                 680                 685                           

gac gcg gcg gcc ctc gag cac gac aag gcc tac gac cag cag ctc aag       2170
Asp Ala Ala Ala Leu Glu His Asp Lys Ala Tyr Asp Gln Gln Leu Lys           
690                 695                 700                 705           

gcc gga gac aac ccg tac ctc aag tac aac cac gcc gac gcc gag ttc       2218
Ala Gly Asp Asn Pro Tyr Leu Lys Tyr Asn His Ala Asp Ala Glu Phe           
                710                 715                 720               

cag gag cgg ctc aaa gaa gat acg tct ttt ggg ggc aac ctc ggg cga       2266
Gln Glu Arg Leu Lys Glu Asp Thr Ser Phe Gly Gly Asn Leu Gly Arg           
            725                 730                 735                   

gca gtc ttc cag gcc aaa aag agg ctt ctt gaa cct ctt ggt ctg gtt       2314
Ala Val Phe Gln Ala Lys Lys Arg Leu Leu Glu Pro Leu Gly Leu Val           
        740                 745                 750                       

gag gaa gcg gct aag acg gct cct gga aag aag agg cct gta gag cag       2362
Glu Glu Ala Ala Lys Thr Ala Pro Gly Lys Lys Arg Pro Val Glu Gln           
    755                 760                 765                           

tct cct cag gaa ccg gac tcc tcc gcg ggt att ggc aaa tcg ggt gca       2410
Ser Pro Gln Glu Pro Asp Ser Ser Ala Gly Ile Gly Lys Ser Gly Ala           
770                 775                 780                 785           

cag ccc gct aaa aag aga ctc aat ttc ggt cag act ggc gac aca gag       2458
Gln Pro Ala Lys Lys Arg Leu Asn Phe Gly Gln Thr Gly Asp Thr Glu           
                790                 795                 800               

tca gtc cca gac cct caa cca atc gga gaa cct ccc gca gcc ccc tca       2506
Ser Val Pro Asp Pro Gln Pro Ile Gly Glu Pro Pro Ala Ala Pro Ser           
            805                 810                 815                   

ggt gtg gga tct ctt aca atg gct tca ggt ggt ggc gca cca gtg gca       2554
Gly Val Gly Ser Leu Thr Met Ala Ser Gly Gly Gly Ala Pro Val Ala           
        820                 825                 830                       

gac aat aac gaa ggt gcc gat gga gtg ggt agt tcc tcg gga aat tgg       2602
Asp Asn Asn Glu Gly Ala Asp Gly Val Gly Ser Ser Ser Gly Asn Trp           
    835                 840                 845                           

cat tgc gat tcc caa tgg ctg ggg gac aga gtc atc acc acc agc acc       2650
His Cys Asp Ser Gln Trp Leu Gly Asp Arg Val Ile Thr Thr Ser Thr           
850                 855                 860                 865           

cga acc tgg gcc ctg ccc acc tac aac aat cac ctc tac aag caa atc       2698
Arg Thr Trp Ala Leu Pro Thr Tyr Asn Asn His Leu Tyr Lys Gln Ile           
                870                 875                 880               

tcc aac agc aca tct gga gga tct tca aat gac aac gcc tac ttc ggc       2746
Ser Asn Ser Thr Ser Gly Gly Ser Ser Asn Asp Asn Ala Tyr Phe Gly           
            885                 890                 895                   

tac agc acc ccc tgg ggg tat ttt gac ttc aac aga ttc cac tgc cac       2794
Tyr Ser Thr Pro Trp Gly Tyr Phe Asp Phe Asn Arg Phe His Cys His           
        900                 905                 910                       

ttc tca cca cgt gac tgg cag cga ctc atc aac aac aac tgg gga ttc       2842
Phe Ser Pro Arg Asp Trp Gln Arg Leu Ile Asn Asn Asn Trp Gly Phe           
    915                 920                 925                           

cgg cct aag cga ctc aac ttc aag ctc ttc aac att cag gtc aaa gag       2890
Arg Pro Lys Arg Leu Asn Phe Lys Leu Phe Asn Ile Gln Val Lys Glu           
930                 935                 940                 945           

gtt acg gac aac aat gga gtc aag acc atc gcc aat aac ctt acc agc       2938
Val Thr Asp Asn Asn Gly Val Lys Thr Ile Ala Asn Asn Leu Thr Ser           
                950                 955                 960               

acg gtc cag gtc ttc acg gac tca gac tat cag ctc ccg tac gtg ctc       2986
Thr Val Gln Val Phe Thr Asp Ser Asp Tyr Gln Leu Pro Tyr Val Leu           
            965                 970                 975                   

ggg tcg gct cac gag ggc tgc ctc ccg ccg ttc cca gcg gac gtt ttc       3034
Gly Ser Ala His Glu Gly Cys Leu Pro Pro Phe Pro Ala Asp Val Phe           
        980                 985                 990                       

atg att cct cag tac ggg tat  ctg acg ctt aat gat  gga agc cag gcc     3082
Met Ile Pro Gln Tyr Gly Tyr  Leu Thr Leu Asn Asp  Gly Ser Gln Ala         
    995                 1000                 1005                         

gtg  ggt cgt tcg tcc ttt  tac tgc ctg gaa tat  ttc ccg tcg caa        3127
Val  Gly Arg Ser Ser Phe  Tyr Cys Leu Glu Tyr  Phe Pro Ser Gln            
1010                 1015                 1020                            

atg  cta aga acg ggt aac  aac ttc cag ttc agc  tac gag ttt gag        3172
Met  Leu Arg Thr Gly Asn  Asn Phe Gln Phe Ser  Tyr Glu Phe Glu            
1025                 1030                 1035                            

aac  gta cct ttc cat agc  agc tac gct cac agc  caa agc ctg gac        3217
Asn  Val Pro Phe His Ser  Ser Tyr Ala His Ser  Gln Ser Leu Asp            
1040                 1045                 1050                            

cga  cta atg aat cca ctc  atc gac caa tac ttg  tac tat ctc tca        3262
Arg  Leu Met Asn Pro Leu  Ile Asp Gln Tyr Leu  Tyr Tyr Leu Ser            
1055                 1060                 1065                            

aag  act att aac ggt tct  gga cag aat caa caa  acg cta aaa ttc        3307
Lys  Thr Ile Asn Gly Ser  Gly Gln Asn Gln Gln  Thr Leu Lys Phe            
1070                 1075                 1080                            

agt  gtg gcc gga ccc agc  aac atg gct gtc cag  gga aga aac tac        3352
Ser  Val Ala Gly Pro Ser  Asn Met Ala Val Gln  Gly Arg Asn Tyr            
1085                 1090                 1095                            

ata  cct gga ccc agc tac  cga caa caa cgt gtc  tca acc act gtg        3397
Ile  Pro Gly Pro Ser Tyr  Arg Gln Gln Arg Val  Ser Thr Thr Val            
1100                 1105                 1110                            

act  caa aac aac aac agc  gaa ttt gct tgg cct  gga gct tct tct        3442
Thr  Gln Asn Asn Asn Ser  Glu Phe Ala Trp Pro  Gly Ala Ser Ser            
1115                 1120                 1125                            

tgg  gct ctc aat gga cgt  aat agc ttg atg aat  cct gga cct gct        3487
Trp  Ala Leu Asn Gly Arg  Asn Ser Leu Met Asn  Pro Gly Pro Ala            
1130                 1135                 1140                            

atg  gcc agc cac aaa gaa  gga gag gac cgt ttc  ttt cct ttg tct        3532
Met  Ala Ser His Lys Glu  Gly Glu Asp Arg Phe  Phe Pro Leu Ser            
1145                 1150                 1155                            

gga  tct tta att ttt ggc  aaa caa gga act gga  aga gac aac gtg        3577
Gly  Ser Leu Ile Phe Gly  Lys Gln Gly Thr Gly  Arg Asp Asn Val            
1160                 1165                 1170                            

gat  gcg gac aaa gtc atg  ata acc aac gaa gaa  gaa att aaa act        3622
Asp  Ala Asp Lys Val Met  Ile Thr Asn Glu Glu  Glu Ile Lys Thr            
1175                 1180                 1185                            

act  aac ccg gta gca acg  gag tcc tat gga caa  gtg gcc aca aac        3667
Thr  Asn Pro Val Ala Thr  Glu Ser Tyr Gly Gln  Val Ala Thr Asn            
1190                 1195                 1200                            

cac  cag agt gcc caa tac  ggc tac ggc aac ccc  gcc acc cgc tac        3712
His  Gln Ser Ala Gln Tyr  Gly Tyr Gly Asn Pro  Ala Thr Arg Tyr            
1205                 1210                 1215                            

ttc  gac gtg gca cag gcg  cag acc ggc tgg gtt  caa aac caa gga        3757
Phe  Asp Val Ala Gln Ala  Gln Thr Gly Trp Val  Gln Asn Gln Gly            
1220                 1225                 1230                            

ata  ctt ccg ggt atg gtt  tgg cag gac aga gat  gtg tac ctg caa        3802
Ile  Leu Pro Gly Met Val  Trp Gln Asp Arg Asp  Val Tyr Leu Gln            
1235                 1240                 1245                            

gga  ccc att tgg gcc aaa  att cct cac acg gac  ggc aac ttt cac        3847
Gly  Pro Ile Trp Ala Lys  Ile Pro His Thr Asp  Gly Asn Phe His            
1250                 1255                 1260                            

cct  tct ccg ctg atg gga  ggg ttt gga atg aag  cac ccg cct cct        3892
Pro  Ser Pro Leu Met Gly  Gly Phe Gly Met Lys  His Pro Pro Pro            
1265                 1270                 1275                            

cag  atc ctc atc aaa aac  aca cct gta cct gcg  gat cct cca acg        3937
Gln  Ile Leu Ile Lys Asn  Thr Pro Val Pro Ala  Asp Pro Pro Thr            
1280                 1285                 1290                            

gcc  ttc aac aag gac aag  ctg aac tct ttc atc  acc cag tat tct        3982
Ala  Phe Asn Lys Asp Lys  Leu Asn Ser Phe Ile  Thr Gln Tyr Ser            
1295                 1300                 1305                            

act  ggc caa gtc agc gtg  gag atc gag tgg gag  ctg cag aag gaa        4027
Thr  Gly Gln Val Ser Val  Glu Ile Glu Trp Glu  Leu Gln Lys Glu            
1310                 1315                 1320                            

aac  agc aag cgc tgg aac  ccg gag atc cag tac  act tcc aac tat        4072
Asn  Ser Lys Arg Trp Asn  Pro Glu Ile Gln Tyr  Thr Ser Asn Tyr            
1325                 1330                 1335                            

tac  aag tct aat aat gtt  gaa ttt gct gtt aat  act gaa ggt gta        4117
Tyr  Lys Ser Asn Asn Val  Glu Phe Ala Val Asn  Thr Glu Gly Val            
1340                 1345                 1350                            

tat  agt gaa ccc cgc ccc  att ggc acc aga tac  ctg act cgt aat        4162
Tyr  Ser Glu Pro Arg Pro  Ile Gly Thr Arg Tyr  Leu Thr Arg Asn            
1355                 1360                 1365                            

ctg  taa ttgcttgtta atcaataaac cgtttaattc gtttcagttg aactttggtc       4218
Leu                                                                       
1370                                                                      

tctgcgaagg gcgaattcgt ttaaacctgc aggactagag gtcctgtatt agaggtcacg     4278

tgagtgtttt gcgacatttt gcgacaccat gtggtcacgc tgggtattta agcccgagtg     4338

agcacgcagg gtctccattt tgaagcggga ggtttgaacg cgcagccgcc aagccgaatt     4398

ctgcagatat ccatcacact ggcggccgct cgactagagc ggccgccacc gcggtggagc     4458

tccagctttt gttcccttta gtgagggtta attgcgcgct tggcgtaatc atggtcatag     4518

ctgtttcctg tgtgaaattg ttatccgctc acaattccac acaacatacg agccggaagc     4578

ataaagtgta aagcctgggg tgcctaatga gtgagctaac tcacattaat tgcgttgcgc     4638

tcactgcccg ctttccagtc gggaaacctg tcgtgccagc tgcattaatg aatcggccaa     4698

cgcgcgggga gaggcggttt gcgtattggg cgc                                  4731


<210>  22
<211>  621
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic Construct

<400>  22

Met Pro Gly Phe Tyr Glu Ile Val Ile Lys Val Pro Ser Asp Leu Asp 
1               5                   10                  15      


Glu His Leu Pro Gly Ile Ser Asp Ser Phe Val Asn Trp Val Ala Glu 
            20                  25                  30          


Lys Glu Trp Glu Leu Pro Pro Asp Ser Asp Met Asp Leu Asn Leu Ile 
        35                  40                  45              


Glu Gln Ala Pro Leu Thr Val Ala Glu Lys Leu Gln Arg Asp Phe Leu 
    50                  55                  60                  


Thr Glu Trp Arg Arg Val Ser Lys Ala Pro Glu Ala Leu Phe Phe Val 
65                  70                  75                  80  


Gln Phe Glu Lys Gly Glu Ser Tyr Phe His Met His Val Leu Val Glu 
                85                  90                  95      


Thr Thr Gly Val Lys Ser Met Val Leu Gly Arg Phe Leu Ser Gln Ile 
            100                 105                 110         


Arg Glu Lys Leu Ile Gln Arg Ile Tyr Arg Gly Ile Glu Pro Thr Leu 
        115                 120                 125             


Pro Asn Trp Phe Ala Val Thr Lys Thr Arg Asn Gly Ala Gly Gly Gly 
    130                 135                 140                 


Asn Lys Val Val Asp Glu Cys Tyr Ile Pro Asn Tyr Leu Leu Pro Lys 
145                 150                 155                 160 


Thr Gln Pro Glu Leu Gln Trp Ala Trp Thr Asn Met Glu Gln Tyr Leu 
                165                 170                 175     


Ser Ala Cys Leu Asn Leu Thr Glu Arg Lys Arg Leu Val Ala Gln His 
            180                 185                 190         


Leu Thr His Val Ser Gln Thr Gln Glu Gln Asn Lys Glu Asn Gln Asn 
        195                 200                 205             


Pro Asn Ser Asp Ala Pro Val Ile Arg Ser Lys Thr Ser Ala Arg Tyr 
    210                 215                 220                 


Met Glu Leu Val Gly Trp Leu Val Asp Lys Gly Ile Thr Ser Glu Lys 
225                 230                 235                 240 


Gln Trp Ile Gln Glu Asp Gln Ala Ser Tyr Ile Ser Phe Asn Ala Ala 
                245                 250                 255     


Ser Asn Ser Arg Ser Gln Ile Lys Ala Ala Leu Asp Asn Ala Gly Lys 
            260                 265                 270         


Ile Met Ser Leu Thr Lys Thr Ala Pro Asp Tyr Leu Val Gly Gln Gln 
        275                 280                 285             


Pro Val Glu Asp Ile Ser Ser Asn Arg Ile Tyr Lys Ile Leu Glu Leu 
    290                 295                 300                 


Asn Gly Tyr Asp Pro Gln Tyr Ala Ala Ser Val Phe Leu Gly Trp Ala 
305                 310                 315                 320 


Thr Lys Lys Phe Gly Lys Arg Asn Thr Ile Trp Leu Phe Gly Pro Ala 
                325                 330                 335     


Thr Thr Gly Lys Thr Asn Ile Ala Glu Ala Ile Ala His Thr Val Pro 
            340                 345                 350         


Phe Tyr Gly Cys Val Asn Trp Thr Asn Glu Asn Phe Pro Phe Asn Asp 
        355                 360                 365             


Cys Val Asp Lys Met Val Ile Trp Trp Glu Glu Gly Lys Met Thr Ala 
    370                 375                 380                 


Lys Val Val Glu Ser Ala Lys Ala Ile Leu Gly Gly Ser Lys Val Arg 
385                 390                 395                 400 


Val Asp Gln Lys Cys Lys Ser Ser Ala Gln Ile Asp Pro Thr Pro Val 
                405                 410                 415     


Ile Val Thr Ser Asn Thr Asn Met Cys Ala Val Ile Asp Gly Asn Ser 
            420                 425                 430         


Thr Thr Phe Glu His Gln Gln Pro Leu Gln Asp Arg Met Phe Lys Phe 
        435                 440                 445             


Glu Leu Thr Arg Arg Leu Asp His Asp Phe Gly Lys Val Thr Lys Gln 
    450                 455                 460                 


Glu Val Lys Asp Phe Phe Arg Trp Ala Lys Asp His Val Val Glu Val 
465                 470                 475                 480 


Glu His Glu Phe Tyr Val Lys Lys Gly Gly Ala Lys Lys Arg Pro Ala 
                485                 490                 495     


Pro Ser Asp Ala Asp Ile Ser Glu Pro Lys Arg Val Arg Glu Ser Val 
            500                 505                 510         


Ala Gln Pro Ser Thr Ser Asp Ala Glu Ala Ser Ile Asn Tyr Ala Asp 
        515                 520                 525             


Arg Tyr Gln Asn Lys Cys Ser Arg His Val Gly Met Asn Leu Met Leu 
    530                 535                 540                 


Phe Pro Cys Arg Gln Cys Glu Arg Met Asn Gln Asn Ser Asn Ile Cys 
545                 550                 555                 560 


Phe Thr His Gly Gln Lys Asp Cys Leu Glu Cys Phe Pro Val Ser Glu 
                565                 570                 575     


Ser Gln Pro Val Ser Val Val Lys Lys Ala Tyr Gln Lys Leu Cys Tyr 
            580                 585                 590         


Ile His His Ile Met Gly Lys Val Pro Asp Ala Cys Thr Ala Cys Asp 
        595                 600                 605             


Leu Val Asn Val Asp Leu Asp Asp Cys Ile Phe Glu Gln 
    610                 615                 620     


<210>  23
<211>  749
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic Construct

<400>  23

Met Ala Ala Asp Gly Tyr Leu Pro Asp Trp Leu Glu Asp Asn Leu Ser 
1               5                   10                  15      


Glu Gly Ile Arg Glu Trp Trp Ala Leu Lys Pro Gly Ala Pro Gln Pro 
            20                  25                  30          


Lys Ala Asn Gln Gln His Gln Asp Asn Ala Arg Gly Leu Val Leu Pro 
        35                  40                  45              


Gly Tyr Lys Tyr Leu Gly Pro Gly Asn Gly Leu Asp Lys Gly Glu Pro 
    50                  55                  60                  


Val Asn Ala Ala Asp Ala Ala Ala Leu Glu His Asp Lys Ala Tyr Asp 
65                  70                  75                  80  


Gln Gln Leu Lys Ala Gly Asp Asn Pro Tyr Leu Lys Tyr Asn His Ala 
                85                  90                  95      


Asp Ala Glu Phe Gln Glu Arg Leu Lys Glu Asp Thr Ser Phe Gly Gly 
            100                 105                 110         


Asn Leu Gly Arg Ala Val Phe Gln Ala Lys Lys Arg Leu Leu Glu Pro 
        115                 120                 125             


Leu Gly Leu Val Glu Glu Ala Ala Lys Thr Ala Pro Gly Lys Lys Arg 
    130                 135                 140                 


Pro Val Glu Gln Ser Pro Gln Glu Pro Asp Ser Ser Ala Gly Ile Gly 
145                 150                 155                 160 


Lys Ser Gly Ala Gln Pro Ala Lys Lys Arg Leu Asn Phe Gly Gln Thr 
                165                 170                 175     


Gly Asp Thr Glu Ser Val Pro Asp Pro Gln Pro Ile Gly Glu Pro Pro 
            180                 185                 190         


Ala Ala Pro Ser Gly Val Gly Ser Leu Thr Met Ala Ser Gly Gly Gly 
        195                 200                 205             


Ala Pro Val Ala Asp Asn Asn Glu Gly Ala Asp Gly Val Gly Ser Ser 
    210                 215                 220                 


Ser Gly Asn Trp His Cys Asp Ser Gln Trp Leu Gly Asp Arg Val Ile 
225                 230                 235                 240 


Thr Thr Ser Thr Arg Thr Trp Ala Leu Pro Thr Tyr Asn Asn His Leu 
                245                 250                 255     


Tyr Lys Gln Ile Ser Asn Ser Thr Ser Gly Gly Ser Ser Asn Asp Asn 
            260                 265                 270         


Ala Tyr Phe Gly Tyr Ser Thr Pro Trp Gly Tyr Phe Asp Phe Asn Arg 
        275                 280                 285             


Phe His Cys His Phe Ser Pro Arg Asp Trp Gln Arg Leu Ile Asn Asn 
    290                 295                 300                 


Asn Trp Gly Phe Arg Pro Lys Arg Leu Asn Phe Lys Leu Phe Asn Ile 
305                 310                 315                 320 


Gln Val Lys Glu Val Thr Asp Asn Asn Gly Val Lys Thr Ile Ala Asn 
                325                 330                 335     


Asn Leu Thr Ser Thr Val Gln Val Phe Thr Asp Ser Asp Tyr Gln Leu 
            340                 345                 350         


Pro Tyr Val Leu Gly Ser Ala His Glu Gly Cys Leu Pro Pro Phe Pro 
        355                 360                 365             


Ala Asp Val Phe Met Ile Pro Gln Tyr Gly Tyr Leu Thr Leu Asn Asp 
    370                 375                 380                 


Gly Ser Gln Ala Val Gly Arg Ser Ser Phe Tyr Cys Leu Glu Tyr Phe 
385                 390                 395                 400 


Pro Ser Gln Met Leu Arg Thr Gly Asn Asn Phe Gln Phe Ser Tyr Glu 
                405                 410                 415     


Phe Glu Asn Val Pro Phe His Ser Ser Tyr Ala His Ser Gln Ser Leu 
            420                 425                 430         


Asp Arg Leu Met Asn Pro Leu Ile Asp Gln Tyr Leu Tyr Tyr Leu Ser 
        435                 440                 445             


Lys Thr Ile Asn Gly Ser Gly Gln Asn Gln Gln Thr Leu Lys Phe Ser 
    450                 455                 460                 


Val Ala Gly Pro Ser Asn Met Ala Val Gln Gly Arg Asn Tyr Ile Pro 
465                 470                 475                 480 


Gly Pro Ser Tyr Arg Gln Gln Arg Val Ser Thr Thr Val Thr Gln Asn 
                485                 490                 495     


Asn Asn Ser Glu Phe Ala Trp Pro Gly Ala Ser Ser Trp Ala Leu Asn 
            500                 505                 510         


Gly Arg Asn Ser Leu Met Asn Pro Gly Pro Ala Met Ala Ser His Lys 
        515                 520                 525             


Glu Gly Glu Asp Arg Phe Phe Pro Leu Ser Gly Ser Leu Ile Phe Gly 
    530                 535                 540                 


Lys Gln Gly Thr Gly Arg Asp Asn Val Asp Ala Asp Lys Val Met Ile 
545                 550                 555                 560 


Thr Asn Glu Glu Glu Ile Lys Thr Thr Asn Pro Val Ala Thr Glu Ser 
                565                 570                 575     


Tyr Gly Gln Val Ala Thr Asn His Gln Ser Ala Gln Tyr Gly Tyr Gly 
            580                 585                 590         


Asn Pro Ala Thr Arg Tyr Phe Asp Val Ala Gln Ala Gln Thr Gly Trp 
        595                 600                 605             


Val Gln Asn Gln Gly Ile Leu Pro Gly Met Val Trp Gln Asp Arg Asp 
    610                 615                 620                 


Val Tyr Leu Gln Gly Pro Ile Trp Ala Lys Ile Pro His Thr Asp Gly 
625                 630                 635                 640 


Asn Phe His Pro Ser Pro Leu Met Gly Gly Phe Gly Met Lys His Pro 
                645                 650                 655     


Pro Pro Gln Ile Leu Ile Lys Asn Thr Pro Val Pro Ala Asp Pro Pro 
            660                 665                 670         


Thr Ala Phe Asn Lys Asp Lys Leu Asn Ser Phe Ile Thr Gln Tyr Ser 
        675                 680                 685             


Thr Gly Gln Val Ser Val Glu Ile Glu Trp Glu Leu Gln Lys Glu Asn 
    690                 695                 700                 


Ser Lys Arg Trp Asn Pro Glu Ile Gln Tyr Thr Ser Asn Tyr Tyr Lys 
705                 710                 715                 720 


Ser Asn Asn Val Glu Phe Ala Val Asn Thr Glu Gly Val Tyr Ser Glu 
                725                 730                 735     


Pro Arg Pro Ile Gly Thr Arg Tyr Leu Thr Arg Asn Leu 
            740                 745                 


<210>  24
<211>  39
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  nucleic acid sequence YGY2A

<400>  24
tatgcgtatg gcaacccggc gacccgttat tttgatgtg                              39


<210>  25
<211>  39
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  nucleic acid sequence YGY

<400>  25
tacggctacg gcaaccccgc cacccgctac ttcgacgtg                              39


<210>  26
<211>  2250
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  AAV9 cap n588 YGY2A nucleic acid sequence


<220>
<221>  misc_feature
<222>  (1765)..(1803)
<223>  YGY2A

<400>  26
atggctgccg atggttatct tccagattgg ctcgaggaca accttagtga aggaattcgc       60

gagtggtggg ctttgaaacc tggagcccct caacccaagg caaatcaaca acatcaagac      120

aacgctcgag gtcttgtgct tccgggttac aaataccttg gacccggcaa cggactcgac      180

aagggggagc cggtcaacgc agcagacgcg gcggccctcg agcacgacaa ggcctacgac      240

cagcagctca aggccggaga caacccgtac ctcaagtaca accacgccga cgccgagttc      300

caggagcggc tcaaagaaga tacgtctttt gggggcaacc tcgggcgagc agtcttccag      360

gccaaaaaga ggcttcttga acctcttggt ctggttgagg aagcggctaa gacggctcct      420

ggaaagaaga ggcctgtaga gcagtctcct caggaaccgg actcctccgc gggtattggc      480

aaatcgggtg cacagcccgc taaaaagaga ctcaatttcg gtcagactgg cgacacagag      540

tcagtcccag accctcaacc aatcggagaa cctcccgcag ccccctcagg tgtgggatct      600

cttacaatgg cttcaggtgg tggcgcacca gtggcagaca ataacgaagg tgccgatgga      660

gtgggtagtt cctcgggaaa ttggcattgc gattcccaat ggctggggga cagagtcatc      720

accaccagca cccgaacctg ggccctgccc acctacaaca atcacctcta caagcaaatc      780

tccaacagca catctggagg atcttcaaat gacaacgcct acttcggcta cagcaccccc      840

tgggggtatt ttgacttcaa cagattccac tgccacttct caccacgtga ctggcagcga      900

ctcatcaaca acaactgggg attccggcct aagcgactca acttcaagct cttcaacatt      960

caggtcaaag aggttacgga caacaatgga gtcaagacca tcgccaataa ccttaccagc     1020

acggtccagg tcttcacgga ctcagactat cagctcccgt acgtgctcgg gtcggctcac     1080

gagggctgcc tcccgccgtt cccagcggac gttttcatga ttcctcagta cgggtatctg     1140

acgcttaatg atggaagcca ggccgtgggt cgttcgtcct tttactgcct ggaatatttc     1200

ccgtcgcaaa tgctaagaac gggtaacaac ttccagttca gctacgagtt tgagaacgta     1260

cctttccata gcagctacgc tcacagccaa agcctggacc gactaatgaa tccactcatc     1320

gaccaatact tgtactatct ctcaaagact attaacggtt ctggacagaa tcaacaaacg     1380

ctaaaattca gtgtggccgg acccagcaac atggctgtcc agggaagaaa ctacatacct     1440

ggacccagct accgacaaca acgtgtctca accactgtga ctcaaaacaa caacagcgaa     1500

tttgcttggc ctggagcttc ttcttgggct ctcaatggac gtaatagctt gatgaatcct     1560

ggacctgcta tggccagcca caaagaagga gaggaccgtt tctttccttt gtctggatct     1620

ttaatttttg gcaaacaagg aactggaaga gacaacgtgg atgcggacaa agtcatgata     1680

accaacgaag aagaaattaa aactactaac ccggtagcaa cggagtccta tggacaagtg     1740

gccacaaacc accagagtgc ccaatatgcg tatggcaacc cggcgacccg ttattttgat     1800

gtggcacagg cgcagaccgg ctgggttcaa aaccaaggaa tacttccggg tatggtttgg     1860

caggacagag atgtgtacct gcaaggaccc atttgggcca aaattcctca cacggacggc     1920

aactttcacc cttctccgct gatgggaggg tttggaatga agcacccgcc tcctcagatc     1980

ctcatcaaaa acacacctgt acctgcggat cctccaacgg ccttcaacaa ggacaagctg     2040

aactctttca tcacccagta ttctactggc caagtcagcg tggagatcga gtgggagctg     2100

cagaaggaaa acagcaagcg ctggaacccg gagatccagt acacttccaa ctattacaag     2160

tctaataatg ttgaatttgc tgttaatact gaaggtgtat atagtgaacc ccgccccatt     2220

ggcaccagat acctgactcg taatctgtaa                                      2250


<210>  27
<211>  749
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  AAV9 cap n588 YGY2A amino acid sequence


<220>
<221>  MISC_FEATURE
<222>  (589)..(601)
<223>  YGY2A

<400>  27

Met Ala Ala Asp Gly Tyr Leu Pro Asp Trp Leu Glu Asp Asn Leu Ser 
1               5                   10                  15      


Glu Gly Ile Arg Glu Trp Trp Ala Leu Lys Pro Gly Ala Pro Gln Pro 
            20                  25                  30          


Lys Ala Asn Gln Gln His Gln Asp Asn Ala Arg Gly Leu Val Leu Pro 
        35                  40                  45              


Gly Tyr Lys Tyr Leu Gly Pro Gly Asn Gly Leu Asp Lys Gly Glu Pro 
    50                  55                  60                  


Val Asn Ala Ala Asp Ala Ala Ala Leu Glu His Asp Lys Ala Tyr Asp 
65                  70                  75                  80  


Gln Gln Leu Lys Ala Gly Asp Asn Pro Tyr Leu Lys Tyr Asn His Ala 
                85                  90                  95      


Asp Ala Glu Phe Gln Glu Arg Leu Lys Glu Asp Thr Ser Phe Gly Gly 
            100                 105                 110         


Asn Leu Gly Arg Ala Val Phe Gln Ala Lys Lys Arg Leu Leu Glu Pro 
        115                 120                 125             


Leu Gly Leu Val Glu Glu Ala Ala Lys Thr Ala Pro Gly Lys Lys Arg 
    130                 135                 140                 


Pro Val Glu Gln Ser Pro Gln Glu Pro Asp Ser Ser Ala Gly Ile Gly 
145                 150                 155                 160 


Lys Ser Gly Ala Gln Pro Ala Lys Lys Arg Leu Asn Phe Gly Gln Thr 
                165                 170                 175     


Gly Asp Thr Glu Ser Val Pro Asp Pro Gln Pro Ile Gly Glu Pro Pro 
            180                 185                 190         


Ala Ala Pro Ser Gly Val Gly Ser Leu Thr Met Ala Ser Gly Gly Gly 
        195                 200                 205             


Ala Pro Val Ala Asp Asn Asn Glu Gly Ala Asp Gly Val Gly Ser Ser 
    210                 215                 220                 


Ser Gly Asn Trp His Cys Asp Ser Gln Trp Leu Gly Asp Arg Val Ile 
225                 230                 235                 240 


Thr Thr Ser Thr Arg Thr Trp Ala Leu Pro Thr Tyr Asn Asn His Leu 
                245                 250                 255     


Tyr Lys Gln Ile Ser Asn Ser Thr Ser Gly Gly Ser Ser Asn Asp Asn 
            260                 265                 270         


Ala Tyr Phe Gly Tyr Ser Thr Pro Trp Gly Tyr Phe Asp Phe Asn Arg 
        275                 280                 285             


Phe His Cys His Phe Ser Pro Arg Asp Trp Gln Arg Leu Ile Asn Asn 
    290                 295                 300                 


Asn Trp Gly Phe Arg Pro Lys Arg Leu Asn Phe Lys Leu Phe Asn Ile 
305                 310                 315                 320 


Gln Val Lys Glu Val Thr Asp Asn Asn Gly Val Lys Thr Ile Ala Asn 
                325                 330                 335     


Asn Leu Thr Ser Thr Val Gln Val Phe Thr Asp Ser Asp Tyr Gln Leu 
            340                 345                 350         


Pro Tyr Val Leu Gly Ser Ala His Glu Gly Cys Leu Pro Pro Phe Pro 
        355                 360                 365             


Ala Asp Val Phe Met Ile Pro Gln Tyr Gly Tyr Leu Thr Leu Asn Asp 
    370                 375                 380                 


Gly Ser Gln Ala Val Gly Arg Ser Ser Phe Tyr Cys Leu Glu Tyr Phe 
385                 390                 395                 400 


Pro Ser Gln Met Leu Arg Thr Gly Asn Asn Phe Gln Phe Ser Tyr Glu 
                405                 410                 415     


Phe Glu Asn Val Pro Phe His Ser Ser Tyr Ala His Ser Gln Ser Leu 
            420                 425                 430         


Asp Arg Leu Met Asn Pro Leu Ile Asp Gln Tyr Leu Tyr Tyr Leu Ser 
        435                 440                 445             


Lys Thr Ile Asn Gly Ser Gly Gln Asn Gln Gln Thr Leu Lys Phe Ser 
    450                 455                 460                 


Val Ala Gly Pro Ser Asn Met Ala Val Gln Gly Arg Asn Tyr Ile Pro 
465                 470                 475                 480 


Gly Pro Ser Tyr Arg Gln Gln Arg Val Ser Thr Thr Val Thr Gln Asn 
                485                 490                 495     


Asn Asn Ser Glu Phe Ala Trp Pro Gly Ala Ser Ser Trp Ala Leu Asn 
            500                 505                 510         


Gly Arg Asn Ser Leu Met Asn Pro Gly Pro Ala Met Ala Ser His Lys 
        515                 520                 525             


Glu Gly Glu Asp Arg Phe Phe Pro Leu Ser Gly Ser Leu Ile Phe Gly 
    530                 535                 540                 


Lys Gln Gly Thr Gly Arg Asp Asn Val Asp Ala Asp Lys Val Met Ile 
545                 550                 555                 560 


Thr Asn Glu Glu Glu Ile Lys Thr Thr Asn Pro Val Ala Thr Glu Ser 
                565                 570                 575     


Tyr Gly Gln Val Ala Thr Asn His Gln Ser Ala Gln Tyr Ala Tyr Gly 
            580                 585                 590         


Asn Pro Ala Thr Arg Tyr Phe Asp Val Ala Gln Ala Gln Thr Gly Trp 
        595                 600                 605             


Val Gln Asn Gln Gly Ile Leu Pro Gly Met Val Trp Gln Asp Arg Asp 
    610                 615                 620                 


Val Tyr Leu Gln Gly Pro Ile Trp Ala Lys Ile Pro His Thr Asp Gly 
625                 630                 635                 640 


Asn Phe His Pro Ser Pro Leu Met Gly Gly Phe Gly Met Lys His Pro 
                645                 650                 655     


Pro Pro Gln Ile Leu Ile Lys Asn Thr Pro Val Pro Ala Asp Pro Pro 
            660                 665                 670         


Thr Ala Phe Asn Lys Asp Lys Leu Asn Ser Phe Ile Thr Gln Tyr Ser 
        675                 680                 685             


Thr Gly Gln Val Ser Val Glu Ile Glu Trp Glu Leu Gln Lys Glu Asn 
    690                 695                 700                 


Ser Lys Arg Trp Asn Pro Glu Ile Gln Tyr Thr Ser Asn Tyr Tyr Lys 
705                 710                 715                 720 


Ser Asn Asn Val Glu Phe Ala Val Asn Thr Glu Gly Val Tyr Ser Glu 
                725                 730                 735     


Pro Arg Pro Ile Gly Thr Arg Tyr Leu Thr Arg Asn Leu 
            740                 745                 


<210>  28
<211>  2250
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  AAV9 cap n588 YGY nucleic acid sequence


<220>
<221>  misc_feature
<222>  (1765)..(1803)
<223>  YGY

<400>  28
atggctgccg atggttatct tccagattgg ctcgaggaca accttagtga aggaattcgc       60

gagtggtggg ctttgaaacc tggagcccct caacccaagg caaatcaaca acatcaagac      120

aacgctcgag gtcttgtgct tccgggttac aaataccttg gacccggcaa cggactcgac      180

aagggggagc cggtcaacgc agcagacgcg gcggccctcg agcacgacaa ggcctacgac      240

cagcagctca aggccggaga caacccgtac ctcaagtaca accacgccga cgccgagttc      300

caggagcggc tcaaagaaga tacgtctttt gggggcaacc tcgggcgagc agtcttccag      360

gccaaaaaga ggcttcttga acctcttggt ctggttgagg aagcggctaa gacggctcct      420

ggaaagaaga ggcctgtaga gcagtctcct caggaaccgg actcctccgc gggtattggc      480

aaatcgggtg cacagcccgc taaaaagaga ctcaatttcg gtcagactgg cgacacagag      540

tcagtcccag accctcaacc aatcggagaa cctcccgcag ccccctcagg tgtgggatct      600

cttacaatgg cttcaggtgg tggcgcacca gtggcagaca ataacgaagg tgccgatgga      660

gtgggtagtt cctcgggaaa ttggcattgc gattcccaat ggctggggga cagagtcatc      720

accaccagca cccgaacctg ggccctgccc acctacaaca atcacctcta caagcaaatc      780

tccaacagca catctggagg atcttcaaat gacaacgcct acttcggcta cagcaccccc      840

tgggggtatt ttgacttcaa cagattccac tgccacttct caccacgtga ctggcagcga      900

ctcatcaaca acaactgggg attccggcct aagcgactca acttcaagct cttcaacatt      960

caggtcaaag aggttacgga caacaatgga gtcaagacca tcgccaataa ccttaccagc     1020

acggtccagg tcttcacgga ctcagactat cagctcccgt acgtgctcgg gtcggctcac     1080

gagggctgcc tcccgccgtt cccagcggac gttttcatga ttcctcagta cgggtatctg     1140

acgcttaatg atggaagcca ggccgtgggt cgttcgtcct tttactgcct ggaatatttc     1200

ccgtcgcaaa tgctaagaac gggtaacaac ttccagttca gctacgagtt tgagaacgta     1260

cctttccata gcagctacgc tcacagccaa agcctggacc gactaatgaa tccactcatc     1320

gaccaatact tgtactatct ctcaaagact attaacggtt ctggacagaa tcaacaaacg     1380

ctaaaattca gtgtggccgg acccagcaac atggctgtcc agggaagaaa ctacatacct     1440

ggacccagct accgacaaca acgtgtctca accactgtga ctcaaaacaa caacagcgaa     1500

tttgcttggc ctggagcttc ttcttgggct ctcaatggac gtaatagctt gatgaatcct     1560

ggacctgcta tggccagcca caaagaagga gaggaccgtt tctttccttt gtctggatct     1620

ttaatttttg gcaaacaagg aactggaaga gacaacgtgg atgcggacaa agtcatgata     1680

accaacgaag aagaaattaa aactactaac ccggtagcaa cggagtccta tggacaagtg     1740

gccacaaacc accagagtgc ccaatacggc tacggcaacc ccgccacccg ctacttcgac     1800

gtggcacagg cgcagaccgg ctgggttcaa aaccaaggaa tacttccggg tatggtttgg     1860

caggacagag atgtgtacct gcaaggaccc atttgggcca aaattcctca cacggacggc     1920

aactttcacc cttctccgct gatgggaggg tttggaatga agcacccgcc tcctcagatc     1980

ctcatcaaaa acacacctgt acctgcggat cctccaacgg ccttcaacaa ggacaagctg     2040

aactctttca tcacccagta ttctactggc caagtcagcg tggagatcga gtgggagctg     2100

cagaaggaaa acagcaagcg ctggaacccg gagatccagt acacttccaa ctattacaag     2160

tctaataatg ttgaatttgc tgttaatact gaaggtgtat atagtgaacc ccgccccatt     2220

ggcaccagat acctgactcg taatctgtaa                                      2250


<210>  29
<211>  749
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  AAV9 cap n588 YGY amino acid sequence


<220>
<221>  MISC_FEATURE
<222>  (589)..(601)
<223>  YGY

<400>  29

Met Ala Ala Asp Gly Tyr Leu Pro Asp Trp Leu Glu Asp Asn Leu Ser 
1               5                   10                  15      


Glu Gly Ile Arg Glu Trp Trp Ala Leu Lys Pro Gly Ala Pro Gln Pro 
            20                  25                  30          


Lys Ala Asn Gln Gln His Gln Asp Asn Ala Arg Gly Leu Val Leu Pro 
        35                  40                  45              


Gly Tyr Lys Tyr Leu Gly Pro Gly Asn Gly Leu Asp Lys Gly Glu Pro 
    50                  55                  60                  


Val Asn Ala Ala Asp Ala Ala Ala Leu Glu His Asp Lys Ala Tyr Asp 
65                  70                  75                  80  


Gln Gln Leu Lys Ala Gly Asp Asn Pro Tyr Leu Lys Tyr Asn His Ala 
                85                  90                  95      


Asp Ala Glu Phe Gln Glu Arg Leu Lys Glu Asp Thr Ser Phe Gly Gly 
            100                 105                 110         


Asn Leu Gly Arg Ala Val Phe Gln Ala Lys Lys Arg Leu Leu Glu Pro 
        115                 120                 125             


Leu Gly Leu Val Glu Glu Ala Ala Lys Thr Ala Pro Gly Lys Lys Arg 
    130                 135                 140                 


Pro Val Glu Gln Ser Pro Gln Glu Pro Asp Ser Ser Ala Gly Ile Gly 
145                 150                 155                 160 


Lys Ser Gly Ala Gln Pro Ala Lys Lys Arg Leu Asn Phe Gly Gln Thr 
                165                 170                 175     


Gly Asp Thr Glu Ser Val Pro Asp Pro Gln Pro Ile Gly Glu Pro Pro 
            180                 185                 190         


Ala Ala Pro Ser Gly Val Gly Ser Leu Thr Met Ala Ser Gly Gly Gly 
        195                 200                 205             


Ala Pro Val Ala Asp Asn Asn Glu Gly Ala Asp Gly Val Gly Ser Ser 
    210                 215                 220                 


Ser Gly Asn Trp His Cys Asp Ser Gln Trp Leu Gly Asp Arg Val Ile 
225                 230                 235                 240 


Thr Thr Ser Thr Arg Thr Trp Ala Leu Pro Thr Tyr Asn Asn His Leu 
                245                 250                 255     


Tyr Lys Gln Ile Ser Asn Ser Thr Ser Gly Gly Ser Ser Asn Asp Asn 
            260                 265                 270         


Ala Tyr Phe Gly Tyr Ser Thr Pro Trp Gly Tyr Phe Asp Phe Asn Arg 
        275                 280                 285             


Phe His Cys His Phe Ser Pro Arg Asp Trp Gln Arg Leu Ile Asn Asn 
    290                 295                 300                 


Asn Trp Gly Phe Arg Pro Lys Arg Leu Asn Phe Lys Leu Phe Asn Ile 
305                 310                 315                 320 


Gln Val Lys Glu Val Thr Asp Asn Asn Gly Val Lys Thr Ile Ala Asn 
                325                 330                 335     


Asn Leu Thr Ser Thr Val Gln Val Phe Thr Asp Ser Asp Tyr Gln Leu 
            340                 345                 350         


Pro Tyr Val Leu Gly Ser Ala His Glu Gly Cys Leu Pro Pro Phe Pro 
        355                 360                 365             


Ala Asp Val Phe Met Ile Pro Gln Tyr Gly Tyr Leu Thr Leu Asn Asp 
    370                 375                 380                 


Gly Ser Gln Ala Val Gly Arg Ser Ser Phe Tyr Cys Leu Glu Tyr Phe 
385                 390                 395                 400 


Pro Ser Gln Met Leu Arg Thr Gly Asn Asn Phe Gln Phe Ser Tyr Glu 
                405                 410                 415     


Phe Glu Asn Val Pro Phe His Ser Ser Tyr Ala His Ser Gln Ser Leu 
            420                 425                 430         


Asp Arg Leu Met Asn Pro Leu Ile Asp Gln Tyr Leu Tyr Tyr Leu Ser 
        435                 440                 445             


Lys Thr Ile Asn Gly Ser Gly Gln Asn Gln Gln Thr Leu Lys Phe Ser 
    450                 455                 460                 


Val Ala Gly Pro Ser Asn Met Ala Val Gln Gly Arg Asn Tyr Ile Pro 
465                 470                 475                 480 


Gly Pro Ser Tyr Arg Gln Gln Arg Val Ser Thr Thr Val Thr Gln Asn 
                485                 490                 495     


Asn Asn Ser Glu Phe Ala Trp Pro Gly Ala Ser Ser Trp Ala Leu Asn 
            500                 505                 510         


Gly Arg Asn Ser Leu Met Asn Pro Gly Pro Ala Met Ala Ser His Lys 
        515                 520                 525             


Glu Gly Glu Asp Arg Phe Phe Pro Leu Ser Gly Ser Leu Ile Phe Gly 
    530                 535                 540                 


Lys Gln Gly Thr Gly Arg Asp Asn Val Asp Ala Asp Lys Val Met Ile 
545                 550                 555                 560 


Thr Asn Glu Glu Glu Ile Lys Thr Thr Asn Pro Val Ala Thr Glu Ser 
                565                 570                 575     


Tyr Gly Gln Val Ala Thr Asn His Gln Ser Ala Gln Tyr Gly Tyr Gly 
            580                 585                 590         


Asn Pro Ala Thr Arg Tyr Phe Asp Val Ala Gln Ala Gln Thr Gly Trp 
        595                 600                 605             


Val Gln Asn Gln Gly Ile Leu Pro Gly Met Val Trp Gln Asp Arg Asp 
    610                 615                 620                 


Val Tyr Leu Gln Gly Pro Ile Trp Ala Lys Ile Pro His Thr Asp Gly 
625                 630                 635                 640 


Asn Phe His Pro Ser Pro Leu Met Gly Gly Phe Gly Met Lys His Pro 
                645                 650                 655     


Pro Pro Gln Ile Leu Ile Lys Asn Thr Pro Val Pro Ala Asp Pro Pro 
            660                 665                 670         


Thr Ala Phe Asn Lys Asp Lys Leu Asn Ser Phe Ile Thr Gln Tyr Ser 
        675                 680                 685             


Thr Gly Gln Val Ser Val Glu Ile Glu Trp Glu Leu Gln Lys Glu Asn 
    690                 695                 700                 


Ser Lys Arg Trp Asn Pro Glu Ile Gln Tyr Thr Ser Asn Tyr Tyr Lys 
705                 710                 715                 720 


Ser Asn Asn Val Glu Phe Ala Val Asn Thr Glu Gly Val Tyr Ser Glu 
                725                 730                 735     


Pro Arg Pro Ile Gly Thr Arg Tyr Leu Thr Arg Asn Leu 
            740                 745                 


<210>  30
<211>  50
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  amino acids 566 to 615 of adeno-associated virus 9 capsid

<400>  30

Ile Lys Thr Thr Asn Pro Val Ala Thr Glu Ser Tyr Gly Gln Val Ala 
1               5                   10                  15      


Thr Asn His Gln Ser Ala Gln Ala Gln Ala Gln Thr Gly Trp Val Gln 
            20                  25                  30          


Asn Gln Gly Ile Leu Pro Gly Met Val Trp Gln Asp Arg Asp Val Tyr 
        35                  40                  45              


Leu Gln 
    50  


<210>  31
<211>  50
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  amino acids 565 to 614 of adeno-associated virus 8 capsid

<400>  31

Glu Glu Glu Ile Lys Thr Thr Asn Pro Val Ala Thr Glu Glu Tyr Gly 
1               5                   10                  15      


Ile Val Ala Asp Asn Leu Gln Gln Gln Asn Thr Ala Pro Gln Ile Gly 
            20                  25                  30          


Thr Val Asn Ser Gln Gly Ala Leu Pro Gly Met Val Trp Gln Asn Arg 
        35                  40                  45              


Asp Val 
    50  


<210>  32
<211>  50
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  amino acids 567 to 616 of adeno-associated virus 7 capsid

<400>  32

Ile Arg Pro Thr Asn Pro Val Ala Thr Glu Glu Tyr Gly Ile Val Ser 
1               5                   10                  15      


Ser Asn Leu Gln Ala Ala Asn Thr Ala Ala Gln Thr Gln Val Val Asn 
            20                  25                  30          


Asn Gln Gly Ala Leu Pro Gly Met Val Trp Gln Asn Arg Asp Val Tyr 
        35                  40                  45              


Leu Gln 
    50  


<210>  33
<211>  50
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  amino acids 550 to 599 of adeno-associated virus 6 capsid

<400>  33

Ala Ser Asn Thr Ala Leu Asp Asn Val Met Ile Thr Asp Glu Glu Glu 
1               5                   10                  15      


Ile Lys Ala Thr Asn Pro Val Ala Thr Glu Arg Phe Gly Thr Val Ala 
            20                  25                  30          


Val Asn Leu Gln Ser Ser Ser Thr Asp Pro Ala Thr Gly Asp Val His 
        35                  40                  45              


Val Met 
    50  


<210>  34
<211>  50
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  amino acids 556 to 605 of adeno-associated virus 5 capsid

<400>  34

Gln Pro Val Asn Arg Val Ala Tyr Asn Val Gly Gly Gln Met Ala Thr 
1               5                   10                  15      


Asn Asn Gln Ser Ser Thr Thr Ala Pro Ala Thr Gly Thr Tyr Asn Leu 
            20                  25                  30          


Gln Glu Ile Val Pro Gly Ser Val Trp Met Glu Arg Asp Val Tyr Leu 
        35                  40                  45              


Gln Gly 
    50  


<210>  35
<211>  50
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  amino acids 558 to 607 of adeno-associated virus 4 capsid

<400>  35

Phe Thr Ser Glu Glu Glu Leu Ala Ala Thr Asn Ala Thr Asp Thr Asp 
1               5                   10                  15      


Met Trp Gly Asn Leu Pro Gly Gly Asp Gln Ser Asn Ser Asn Leu Pro 
            20                  25                  30          


Thr Val Asp Arg Leu Thr Ala Leu Gly Ala Val Pro Gly Met Val Trp 
        35                  40                  45              


Gln Asn 
    50  


<210>  36
<211>  50
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  amino acids 564 to 613 of adeno-associated virus 3B capsid

<400>  36

Glu Glu Ile Arg Thr Thr Asn Pro Val Ala Thr Glu Gln Tyr Gly Thr 
1               5                   10                  15      


Val Ala Asn Asn Leu Gln Ser Ser Asn Thr Ala Pro Thr Thr Arg Thr 
            20                  25                  30          


Val Asn Asp Gln Gly Ala Leu Pro Gly Met Val Trp Gln Asp Arg Asp 
        35                  40                  45              


Val Tyr 
    50  


<210>  37
<211>  50
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  amino acids 566 to 615 of adeno-associated virus 2 capsid

<400>  37

Arg Thr Thr Asn Pro Val Ala Thr Glu Gln Tyr Gly Ser Val Ser Thr 
1               5                   10                  15      


Asn Leu Gln Arg Gly Asn Arg Gln Ala Ala Thr Ala Asp Val Asn Thr 
            20                  25                  30          


Gln Gly Val Leu Pro Gly Met Val Trp Gly Asp Arg Asp Val Tyr Leu 
        35                  40                  45              


Gln Gly 
    50  


<210>  38
<211>  50
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  amino acids 566 to 615 of adeno-associated virus 1 capsid

<400>  38

Ile Lys Ala Thr Asn Pro Val Ala Thr Glu Arg Phe Gly Thr Val Ala 
1               5                   10                  15      


Val Asn Phe Gln Ser Ser Ser Thr Asp Pro Ala Thr Gly Asp Val His 
            20                  25                  30          


Ala Met Gly Ala Leu Pro Gly Met Val Trp Gln Asp Arg Asp Val Tyr 
        35                  40                  45              


Leu Gln 
    50  


<210>  39
<211>  542
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  WPRE element (mut)

<400>  39
aatcaacctc tggattacaa aatttgtgaa agattgactg gtattcttaa ctatgttgct       60

ccttttacgc tatgtggata cgctgcttta atgcctttgt atcatgctat tgcttcccgt      120

atggctttca ttttctcctc cttgtataaa tcctggttgc tgtctcttta tgaggagttg      180

tggcccgttg tcaggcaacg tggcgtggtg tgcactgtgt ttgctgacgc aacccccact      240

ggttggggca ttgccaccac ctgtcagctc ctttccggga ctttcgcttt ccccctccct      300

attgccacgg cggaactcat cgccgcctgc cttgcccgct gctggacagg ggctcggctg      360

ttgggcactg acaattccgt ggtgttgtcg gggaaatcat cgtcctttcc ttggctgctc      420

gcctgtgttg ccacctggat tctgcgcggg acgtccttct gctacgtccc ttcggccctc      480

aatccagcgg accttccttc ccgcggcctg ctgccggctc tgcggcctct tccgcgtctt      540

cg                                                                     542


<210>  40
<211>  591
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Wild Type WPRE element (GenBank: J02442.1, nt 1093-1683)

<400>  40
aatcaacctc tggattacaa aatttgtgaa agattgactg atattcttaa ctatgttgct       60

ccttttacgc tgtgtggata tgctgcttta atgcctctgt atcatgctat tgcttcccgt      120

acggctttcg ttttctcctc cttgtataaa tcctggttgc tgtctcttta tgaggagttg      180

tggcccgttg tccgtcaacg tggcgtggtg tgctctgtgt ttgctgacgc aacccccact      240

ggctggggca ttgccaccac ctgtcaactc ctttctggga ctttcgcttt ccccctcccg      300

atcgccacgg cagaactcat cgccgcctgc cttgcccgct gctggacagg ggctaggttg      360

ctgggcactg ataattccgt ggtgttgtcg gggaagctga cgtcctttcc atggctgctc      420

gcctgtgttg ccaactggat cctgcgcggg acgtccttct gctacgtccc ttcggctctc      480

aatccagcgg acctcccttc ccgaggcctt ctgccggttc tgcggcctct cccgcgtctt      540

cgctttcggc ctccgacgag tcggatctcc ctttgggccg cctccccgcc t               591


<210>  41
<211>  11
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  SSNTVKLTSGH peptide sequence

<400>  41

Ser Ser Asn Thr Val Lys Leu Thr Ser Gly His 
1               5                   10      


<210>  42
<211>  15
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  GRTILKENIKYEVAI peptide sequence

<400>  42

Gly Arg Thr Ile Leu Lys Glu Asn Ile Lys Tyr Glu Val Ala Ile 
1               5                   10                  15  


<210>  43
<211>  19
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  GGGRTILKENIKYEVAIGG peptide sequence

<400>  43

Gly Gly Gly Arg Thr Ile Leu Lys Glu Asn Ile Lys Tyr Glu Val Ala 
1               5                   10                  15      


Ile Gly Gly 
            


<210>  44
<211>  15
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  GGSSNTVKLTSGHGG peptide sequence

<400>  44

Gly Gly Ser Ser Asn Thr Val Lys Leu Thr Ser Gly His Gly Gly 
1               5                   10                  15  


<210>  45
<211>  12
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  IEINATRAGTNL peptide sequence

<400>  45

Ile Glu Ile Asn Ala Thr Arg Ala Gly Thr Asn Leu 
1               5                   10          


<210>  46
<211>  16
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  GGVLTNIARGEYMRGG peptide sequence

<400>  46

Gly Gly Val Leu Thr Asn Ile Ala Arg Gly Glu Tyr Met Arg Gly Gly 
1               5                   10                  15      


<210>  47
<211>  16
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  GGIEINATRAGTNLGG peptide sequence

<400>  47

Gly Gly Ile Glu Ile Asn Ala Thr Arg Ala Gly Thr Asn Leu Gly Gly 
1               5                   10                  15      


<210>  48
<211>  19
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  GGPVEFSSNTVKLTSGHGG peptide sequence

<400>  48

Gly Gly Pro Val Glu Phe Ser Ser Asn Thr Val Lys Leu Thr Ser Gly 
1               5                   10                  15      


His Gly Gly 
            


<210>  49
<211>  15
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  GGFLGTPADTGHGGG peptide sequence

<400>  49

Gly Gly Phe Leu Gly Thr Pro Ala Asp Thr Gly His Gly Gly Gly 
1               5                   10                  15  


<210>  50
<211>  12
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  LHRQDNYLAASG peptide sequence

<400>  50

Leu His Arg Gln Asp Asn Tyr Leu Ala Ala Ser Gly 
1               5                   10          


<210>  51
<211>  15
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  GGFTSVGKAVHQVGG peptide sequence

<400>  51

Gly Gly Phe Thr Ser Val Gly Lys Ala Val His Gln Val Gly Gly 
1               5                   10                  15  


<210>  52
<211>  7
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  PMKLDSS peptide sequence

<400>  52

Pro Met Lys Leu Asp Ser Ser 
1               5           


<210>  53
<211>  7
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  ISQTLHG peptide sequence

<400>  53

Ile Ser Gln Thr Leu His Gly 
1               5           


<210>  54
<211>  13
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  GSGLHGPSSTGSG peptide sequence

<400>  54

Gly Ser Gly Leu His Gly Pro Ser Ser Thr Gly Ser Gly 
1               5                   10              


<210>  55
<211>  13
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  GSGISQTLHGGSG peptide sequence

<400>  55

Gly Ser Gly Ile Ser Gln Thr Leu His Gly Gly Ser Gly 
1               5                   10              


<210>  56
<211>  13
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  GSGHTLHGSAGSG peptide sequence

<400>  56

Gly Ser Gly His Thr Leu His Gly Ser Ala Gly Ser Gly 
1               5                   10              


<210>  57
<211>  11
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  GSVGGVFTSVG peptide sequence

<400>  57

Gly Ser Val Gly Gly Val Phe Thr Ser Val Gly 
1               5                   10      


<210>  58
<211>  7
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  STSNLAS peptide sequence

<400>  58

Ser Thr Ser Asn Leu Ala Ser 
1               5           


<210>  59
<211>  7
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  STASTQA peptide sequence

<400>  59

Ser Thr Ala Ser Thr Gln Ala 
1               5           


<210>  60
<211>  15
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  DFGSVGGVFTSVGKA peptide sequence

<400>  60

Asp Phe Gly Ser Val Gly Gly Val Phe Thr Ser Val Gly Lys Ala 
1               5                   10                  15  


<210>  61
<211>  7
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  RASNLES peptide sequence

<400>  61

Arg Ala Ser Asn Leu Glu Ser 
1               5           


<210>  62
<211>  13
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  GSGMLVSSPAGSG peptide sequence

<400>  62

Gly Ser Gly Met Leu Val Ser Ser Pro Ala Gly Ser Gly 
1               5                   10              


<210>  63
<211>  19
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  GGDFGSVGGVFTSVGKAGG peptide sequence

<400>  63

Gly Gly Asp Phe Gly Ser Val Gly Gly Val Phe Thr Ser Val Gly Lys 
1               5                   10                  15      


Ala Gly Gly 
            


<210>  64
<211>  7
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  SYTSSTM peptide sequence

<400>  64

Ser Tyr Thr Ser Ser Thr Met 
1               5           


<210>  65
<211>  7
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  HTLHGSA peptide sequence

<400>  65

His Thr Leu His Gly Ser Ala 
1               5           


