                         SEQUENCE LISTING

<110>  LA JOLLA INSTITUTE OF ALLERGY AND IMMUNOLOGY
       SAPHIRE, Erica Ollmann
       HASTIE, Kathryn
       MOON-WALKER, Alex
 
<120>  ENGINEERED ARENAVIRUS GLYCOPROTEIN COMPOSITIONS, METHODS AND USE 
       THEREOF

<130>  048513-515001WO

<150>  63/257,938
<151>  2021-10-20

<150>  63/177,929
<151>  2021-04-21

<160>  23    

<170>  PatentIn version 3.5

<210>  1
<211>  600
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic Polypeptide

<400>  1

Met Lys Leu Cys Ile Leu Leu Ala Val Val Ala Phe Val Gly Leu Ser 
1               5                   10                  15      


Leu Gly Met Tyr Gly Leu Lys Gly Pro Asp Ile Tyr Lys Gly Val Tyr 
            20                  25                  30          


Gln Phe Lys Ser Val Glu Phe Asp Met Ser His Leu Asn Leu Thr Met 
        35                  40                  45              


Pro Asn Ala Cys Ser Ala Asn Asn Ser His His Tyr Ile Ser Met Gly 
    50                  55                  60                  


Thr Ser Gly Leu Glu Leu Thr Phe Thr Asn Asp Ser Ile Ile Ser His 
65                  70                  75                  80  


Asn Phe Cys Asn Leu Thr Ser Ala Phe Asn Lys Lys Thr Phe Asp His 
                85                  90                  95      


Thr Leu Met Ser Ile Val Ser Ser Leu His Leu Ser Ile Arg Gly Asn 
            100                 105                 110         


Ser Asn Tyr Lys Ala Val Ser Cys Asp Phe Asn Asn Gly Ile Thr Ile 
        115                 120                 125             


Gln Tyr Asn Leu Thr Phe Ser Asp Ala Gln Ser Ala Gln Ser Gln Cys 
    130                 135                 140                 


Arg Thr Phe Arg Gly Arg Val Leu Asp Met Phe Arg Thr Ala Phe Gly 
145                 150                 155                 160 


Gly Lys Tyr Met Arg Ser Cys Trp Gly Trp Thr Gly Ser Asp Gly Lys 
                165                 170                 175     


Thr Thr Trp Cys Ser Gln Thr Ser Tyr Gln Tyr Leu Ile Ile Gln Asn 
            180                 185                 190         


Arg Thr Trp Glu Asn His Cys Thr Tyr Ala Gly Pro Phe Gly Met Ser 
        195                 200                 205             


Arg Ile Leu Leu Ser Gln Glu Lys Thr Lys Phe Leu Thr Arg Arg Arg 
    210                 215                 220                 


Arg Gly Thr Phe Thr Trp Thr Leu Ser Asp Ser Ser Gly Val Glu Asn 
225                 230                 235                 240 


Pro Gly Gly Tyr Cys Leu Thr Lys Trp Met Ile Leu Ala Ala Glu Leu 
                245                 250                 255     


Lys Cys Phe Gly Asn Thr Ala Val Ala Lys Cys Asn Val Asn His Asp 
            260                 265                 270         


Glu Glu Phe Cys Asp Met Leu Arg Leu Ile Asp Tyr Asn Lys Ala Ala 
        275                 280                 285             


Leu Ser Lys Phe Lys Pro Asp Val Glu Ser Ala Leu His Leu Phe Lys 
    290                 295                 300                 


Thr Thr Val Asn Ser Leu Ile Ser Asp Gln Leu Leu Met Arg Asn His 
305                 310                 315                 320 


Leu Arg Asp Leu Met Cys Val Pro Tyr Cys Asn Tyr Ser Lys Phe Trp 
                325                 330                 335     


Tyr Leu Glu His Ala Lys Thr Gly Glu Thr Ser Val Pro Lys Cys Trp 
            340                 345                 350         


Leu Val Thr Asn Gly Ala Tyr Leu Asn Glu Thr His Phe Ser Asp Gln 
        355                 360                 365             


Ile Glu Gln Glu Ala Asp Asn Met Ile Thr Glu Met Leu Arg Lys Asp 
    370                 375                 380                 


Tyr Ile Lys Arg Gln Gly Leu Glu Gly Gly Ser Pro Val Val Glu Val 
385                 390                 395                 400 


Gln Gly Thr Ile Asp Glu Leu Asn Ser Phe Ile Gly Tyr Ala Leu Val 
                405                 410                 415     


Leu Ser Arg Trp Asp Asp Ile Arg Asn Asp Leu Phe Arg Ile Gln Asn 
            420                 425                 430         


Asp Leu Phe Val Leu Gly Glu Asp Val Ser Thr Gly Gly Lys Gly Arg 
        435                 440                 445             


Thr Val Thr Arg Glu Met Ile Asp Tyr Leu Glu Ala Arg Val Lys Glu 
    450                 455                 460                 


Met Lys Ala Glu Ile Gly Lys Ile Glu Leu Phe Val Val Pro Gly Gly 
465                 470                 475                 480 


Ser Val Glu Ser Ala Ser Leu His Met Ala Arg Ala Val Ser Arg Arg 
                485                 490                 495     


Leu Glu Arg Arg Ile Val Ala Ala Ser Lys Leu Thr Glu Ile Asn Lys 
            500                 505                 510         


Asn Val Leu Ile Tyr Ala Asn Arg Leu Ser Ser Ile Leu Phe Met His 
        515                 520                 525             


Ala Leu Ile Ser Asn Lys Arg Leu Asn Ile Pro Glu Lys Ile Trp Ala 
    530                 535                 540                 


Leu Glu Val Asp Asp Asp Asp Lys Ala Gly Trp Ser His Pro Gln Phe 
545                 550                 555                 560 


Glu Lys Gly Gly Gly Ser Gly Gly Gly Ser Gly Gly Gly Ser Trp Ser 
                565                 570                 575     


His Pro Gln Phe Glu Lys Gly Ser Gly Gly Leu Asn Asp Ile Phe Glu 
            580                 585                 590         


Ala Gln Lys Ile Glu Trp His Glu 
        595                 600 


<210>  2
<211>  454
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic Polypeptide

<400>  2

Met Lys Leu Cys Ile Leu Leu Ala Val Val Ala Phe Val Gly Leu Ser 
1               5                   10                  15      


Leu Gly Met Tyr Gly Leu Lys Gly Pro Asp Ile Tyr Lys Gly Val Tyr 
            20                  25                  30          


Gln Phe Lys Ser Val Glu Phe Asp Met Ser His Leu Asn Leu Thr Met 
        35                  40                  45              


Pro Asn Ala Cys Ser Ala Asn Asn Ser His His Tyr Ile Ser Met Gly 
    50                  55                  60                  


Thr Ser Gly Leu Glu Leu Thr Phe Thr Asn Asp Ser Ile Ile Ser His 
65                  70                  75                  80  


Asn Phe Cys Asn Leu Thr Ser Ala Phe Asn Lys Lys Thr Phe Asp His 
                85                  90                  95      


Thr Leu Met Ser Ile Val Ser Ser Leu His Leu Ser Ile Arg Gly Asn 
            100                 105                 110         


Ser Asn Tyr Lys Ala Val Ser Cys Asp Phe Asn Asn Gly Ile Thr Ile 
        115                 120                 125             


Gln Tyr Asn Leu Thr Phe Ser Asp Ala Gln Ser Ala Gln Ser Gln Cys 
    130                 135                 140                 


Arg Thr Phe Arg Gly Arg Val Leu Asp Met Phe Arg Thr Ala Phe Gly 
145                 150                 155                 160 


Gly Lys Tyr Met Arg Ser Cys Trp Gly Trp Thr Gly Ser Asp Gly Lys 
                165                 170                 175     


Thr Thr Trp Cys Ser Gln Thr Ser Tyr Gln Tyr Leu Ile Ile Gln Asn 
            180                 185                 190         


Arg Thr Trp Glu Asn His Cys Thr Tyr Ala Gly Pro Phe Gly Met Ser 
        195                 200                 205             


Arg Ile Leu Leu Ser Gln Glu Lys Thr Lys Phe Leu Thr Arg Arg Arg 
    210                 215                 220                 


Arg Gly Thr Phe Thr Trp Thr Leu Ser Asp Ser Ser Gly Val Glu Asn 
225                 230                 235                 240 


Pro Gly Gly Tyr Cys Leu Thr Lys Trp Met Ile Leu Ala Ala Glu Leu 
                245                 250                 255     


Lys Cys Phe Gly Asn Thr Ala Val Ala Lys Cys Asn Val Asn His Asp 
            260                 265                 270         


Glu Glu Phe Cys Asp Met Leu Arg Leu Ile Asp Tyr Asn Lys Ala Ala 
        275                 280                 285             


Leu Ser Lys Phe Lys Pro Asp Val Glu Ser Ala Leu His Leu Phe Lys 
    290                 295                 300                 


Thr Thr Val Asn Ser Leu Ile Ser Asp Gln Leu Leu Met Arg Asn His 
305                 310                 315                 320 


Leu Arg Asp Leu Met Cys Val Pro Tyr Cys Asn Tyr Ser Lys Phe Trp 
                325                 330                 335     


Tyr Leu Glu His Ala Lys Thr Gly Glu Thr Ser Val Pro Lys Cys Trp 
            340                 345                 350         


Leu Val Thr Asn Gly Ala Tyr Leu Asn Glu Thr His Phe Ser Asp Gln 
        355                 360                 365             


Ile Glu Gln Glu Ala Asp Asn Met Ile Thr Glu Met Leu Arg Lys Asp 
    370                 375                 380                 


Tyr Ile Lys Arg Gln Gly Gly Gly Ser Leu Pro Glu Thr Gly Leu Glu 
385                 390                 395                 400 


Val Asp Asp Asp Asp Lys Ala Gly Trp Ser His Pro Gln Phe Glu Lys 
                405                 410                 415     


Gly Gly Gly Ser Gly Gly Gly Ser Gly Gly Gly Ser Trp Ser His Pro 
            420                 425                 430         


Gln Phe Glu Lys Gly Ser Gly Gly Leu Asn Asp Ile Phe Glu Ala Gln 
        435                 440                 445             


Lys Ile Glu Trp His Glu 
    450                 


<210>  3
<211>  207
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic Polypeptide

<400>  3

Met Tyr Gly Leu Lys Gly Pro Asp Ile Tyr Lys Gly Val Tyr Gln Phe 
1               5                   10                  15      


Lys Ser Val Glu Phe Asp Met Ser His Leu Asn Leu Thr Met Pro Asn 
            20                  25                  30          


Ala Cys Ser Ala Asn Asn Ser His His Tyr Ile Ser Met Gly Thr Ser 
        35                  40                  45              


Gly Leu Glu Leu Thr Phe Thr Asn Asp Ser Ile Ile Ser His Asn Phe 
    50                  55                  60                  


Cys Asn Leu Thr Ser Ala Phe Asn Lys Lys Thr Phe Asp His Thr Leu 
65                  70                  75                  80  


Met Ser Ile Val Ser Ser Leu His Leu Ser Ile Arg Gly Asn Ser Asn 
                85                  90                  95      


Tyr Lys Ala Val Ser Cys Asp Phe Asn Asn Gly Ile Thr Ile Gln Tyr 
            100                 105                 110         


Asn Leu Thr Phe Ser Asp Ala Gln Ser Ala Gln Ser Gln Cys Arg Thr 
        115                 120                 125             


Phe Arg Gly Arg Val Leu Asp Met Phe Arg Thr Ala Phe Gly Gly Lys 
    130                 135                 140                 


Tyr Met Arg Ser Cys Trp Gly Trp Thr Gly Ser Asp Gly Lys Thr Thr 
145                 150                 155                 160 


Trp Cys Ser Gln Thr Ser Tyr Gln Tyr Leu Ile Ile Gln Asn Arg Thr 
                165                 170                 175     


Trp Glu Asn His Cys Thr Tyr Ala Gly Pro Phe Gly Met Ser Arg Ile 
            180                 185                 190         


Leu Leu Ser Gln Glu Lys Thr Lys Phe Leu Thr Arg Arg Arg Arg 
        195                 200                 205         


<210>  4
<211>  165
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic Polypeptide

<400>  4

Gly Thr Phe Thr Trp Thr Leu Ser Asp Ser Ser Gly Val Glu Asn Pro 
1               5                   10                  15      


Gly Gly Tyr Cys Leu Thr Lys Trp Met Ile Leu Ala Ala Glu Leu Lys 
            20                  25                  30          


Cys Phe Gly Asn Thr Ala Val Ala Lys Cys Asn Val Asn His Asp Glu 
        35                  40                  45              


Glu Phe Cys Asp Met Leu Arg Leu Ile Asp Tyr Asn Lys Ala Ala Leu 
    50                  55                  60                  


Ser Lys Phe Lys Pro Asp Val Glu Ser Ala Leu His Leu Phe Lys Thr 
65                  70                  75                  80  


Thr Val Asn Ser Leu Ile Ser Asp Gln Leu Leu Met Arg Asn His Leu 
                85                  90                  95      


Arg Asp Leu Met Cys Val Pro Tyr Cys Asn Tyr Ser Lys Phe Trp Tyr 
            100                 105                 110         


Leu Glu His Ala Lys Thr Gly Glu Thr Ser Val Pro Lys Cys Trp Leu 
        115                 120                 125             


Val Thr Asn Gly Ala Tyr Leu Asn Glu Thr His Phe Ser Asp Gln Ile 
    130                 135                 140                 


Glu Gln Glu Ala Asp Asn Met Ile Thr Glu Met Leu Arg Lys Asp Tyr 
145                 150                 155                 160 


Ile Lys Arg Gln Gly 
                165 


<210>  5
<211>  372
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic Polypeptide

<400>  5

Met Tyr Gly Leu Lys Gly Pro Asp Ile Tyr Lys Gly Val Tyr Gln Phe 
1               5                   10                  15      


Lys Ser Val Glu Phe Asp Met Ser His Leu Asn Leu Thr Met Pro Asn 
            20                  25                  30          


Ala Cys Ser Ala Asn Asn Ser His His Tyr Ile Ser Met Gly Thr Ser 
        35                  40                  45              


Gly Leu Glu Leu Thr Phe Thr Asn Asp Ser Ile Ile Ser His Asn Phe 
    50                  55                  60                  


Cys Asn Leu Thr Ser Ala Phe Asn Lys Lys Thr Phe Asp His Thr Leu 
65                  70                  75                  80  


Met Ser Ile Val Ser Ser Leu His Leu Ser Ile Arg Gly Asn Ser Asn 
                85                  90                  95      


Tyr Lys Ala Val Ser Cys Asp Phe Asn Asn Gly Ile Thr Ile Gln Tyr 
            100                 105                 110         


Asn Leu Thr Phe Ser Asp Ala Gln Ser Ala Gln Ser Gln Cys Arg Thr 
        115                 120                 125             


Phe Arg Gly Arg Val Leu Asp Met Phe Arg Thr Ala Phe Gly Gly Lys 
    130                 135                 140                 


Tyr Met Arg Ser Cys Trp Gly Trp Thr Gly Ser Asp Gly Lys Thr Thr 
145                 150                 155                 160 


Trp Cys Ser Gln Thr Ser Tyr Gln Tyr Leu Ile Ile Gln Asn Arg Thr 
                165                 170                 175     


Trp Glu Asn His Cys Thr Tyr Ala Gly Pro Phe Gly Met Ser Arg Ile 
            180                 185                 190         


Leu Leu Ser Gln Glu Lys Thr Lys Phe Leu Thr Arg Arg Arg Arg Gly 
        195                 200                 205             


Thr Phe Thr Trp Thr Leu Ser Asp Ser Ser Gly Val Glu Asn Pro Gly 
    210                 215                 220                 


Gly Tyr Cys Leu Thr Lys Trp Met Ile Leu Ala Ala Glu Leu Lys Cys 
225                 230                 235                 240 


Phe Gly Asn Thr Ala Val Ala Lys Cys Asn Val Asn His Asp Glu Glu 
                245                 250                 255     


Phe Cys Asp Met Leu Arg Leu Ile Asp Tyr Asn Lys Ala Ala Leu Ser 
            260                 265                 270         


Lys Phe Lys Pro Asp Val Glu Ser Ala Leu His Leu Phe Lys Thr Thr 
        275                 280                 285             


Val Asn Ser Leu Ile Ser Asp Gln Leu Leu Met Arg Asn His Leu Arg 
    290                 295                 300                 


Asp Leu Met Cys Val Pro Tyr Cys Asn Tyr Ser Lys Phe Trp Tyr Leu 
305                 310                 315                 320 


Glu His Ala Lys Thr Gly Glu Thr Ser Val Pro Lys Cys Trp Leu Val 
                325                 330                 335     


Thr Asn Gly Ala Tyr Leu Asn Glu Thr His Phe Ser Asp Gln Ile Glu 
            340                 345                 350         


Gln Glu Ala Asp Asn Met Ile Thr Glu Met Leu Arg Lys Asp Tyr Ile 
        355                 360                 365             


Lys Arg Gln Gly 
    370         


<210>  6
<211>  152
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic Polypeptide

<400>  6

Gly Gly Ser Pro Val Val Glu Val Gln Gly Thr Ile Asp Glu Leu Asn 
1               5                   10                  15      


Ser Phe Ile Gly Tyr Ala Leu Val Leu Ser Arg Trp Asp Asp Ile Arg 
            20                  25                  30          


Asn Asp Leu Phe Arg Ile Gln Asn Asp Leu Phe Val Leu Gly Glu Asp 
        35                  40                  45              


Val Ser Thr Gly Gly Lys Gly Arg Thr Val Thr Arg Glu Met Ile Asp 
    50                  55                  60                  


Tyr Leu Glu Ala Arg Val Lys Glu Met Lys Ala Glu Ile Gly Lys Ile 
65                  70                  75                  80  


Glu Leu Phe Val Val Pro Gly Gly Ser Val Glu Ser Ala Ser Leu His 
                85                  90                  95      


Met Ala Arg Ala Val Ser Arg Arg Leu Glu Arg Arg Ile Val Ala Ala 
            100                 105                 110         


Ser Lys Leu Thr Glu Ile Asn Lys Asn Val Leu Ile Tyr Ala Asn Arg 
        115                 120                 125             


Leu Ser Ser Ile Leu Phe Met His Ala Leu Ile Ser Asn Lys Arg Leu 
    130                 135                 140                 


Asn Ile Pro Glu Lys Ile Trp Ala 
145                 150         


<210>  7
<211>  5
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic Polypeptide

<400>  7

Leu Pro Glu Thr Gly 
1               5   


<210>  8
<211>  2
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic Polypeptide

<400>  8

Leu Glu 
1       


<210>  9
<211>  3
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic Polypeptide

<400>  9

Gly Gly Ser 
1           


<210>  10
<211>  18
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic Polypeptide

<400>  10

Met Lys Leu Cys Ile Leu Leu Ala Val Val Ala Phe Val Gly Leu Ser 
1               5                   10                  15      


Leu Gly 
        


<210>  11
<211>  3
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic Polypeptide

<400>  11

Leu Glu Val 
1           


<210>  12
<211>  5
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic Polypeptide

<400>  12

Asp Asp Asp Asp Lys 
1               5   


<210>  13
<211>  2
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic Polypeptide

<400>  13

Ala Gly 
1       


<210>  14
<211>  8
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic Polypeptide

<400>  14

Trp Ser His Pro Gln Phe Glu Lys 
1               5               


<210>  15
<211>  12
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic Polypeptide

<400>  15

Gly Gly Gly Ser Gly Gly Gly Ser Gly Gly Gly Ser 
1               5                   10          


<210>  16
<211>  3
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic Polypeptide

<400>  16

Gly Ser Gly 
1           


<210>  17
<211>  15
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic Polypeptide

<400>  17

Gly Leu Asn Asp Ile Phe Glu Ala Gln Lys Ile Glu Trp His Glu 
1               5                   10                  15  


<210>  18
<211>  207
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic Polypeptide

<400>  18

Met Tyr Gly Leu Lys Gly Pro Asp Ile Tyr Lys Gly Val Tyr Gln Phe 
1               5                   10                  15      


Lys Ser Val Glu Phe Asp Met Ser His Leu Asn Leu Thr Met Pro Asn 
            20                  25                  30          


Ala Cys Ser Ala Asn Asn Ser His His Tyr Ile Ser Met Gly Thr Ser 
        35                  40                  45              


Gly Leu Glu Leu Thr Phe Thr Asn Asp Ser Ile Ile Ser His Asn Phe 
    50                  55                  60                  


Cys Asn Leu Thr Ser Ala Phe Asn Lys Lys Thr Phe Asp His Thr Leu 
65                  70                  75                  80  


Met Ser Ile Val Ser Ser Leu His Leu Ser Ile Arg Gly Asn Ser Asn 
                85                  90                  95      


Tyr Lys Ala Val Ser Cys Asp Phe Asn Asn Gly Ile Thr Ile Gln Tyr 
            100                 105                 110         


Asn Leu Thr Phe Ser Asp Ala Gln Ser Ala Gln Ser Gln Cys Arg Thr 
        115                 120                 125             


Phe Arg Gly Arg Val Leu Asp Met Phe Arg Thr Ala Phe Gly Gly Lys 
    130                 135                 140                 


Tyr Met Arg Ser Gly Trp Gly Trp Thr Gly Ser Asp Gly Lys Thr Thr 
145                 150                 155                 160 


Trp Cys Ser Gln Thr Ser Tyr Gln Tyr Leu Ile Ile Gln Asn Arg Thr 
                165                 170                 175     


Trp Glu Asn His Cys Thr Tyr Ala Gly Pro Phe Gly Met Ser Arg Ile 
            180                 185                 190         


Leu Leu Ser Gln Glu Lys Thr Lys Phe Leu Thr Arg Arg Leu Ala 
        195                 200                 205         


<210>  19
<211>  165
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic Polypeptide

<400>  19

Gly Thr Phe Thr Trp Thr Leu Ser Asp Ser Ser Gly Val Glu Asn Pro 
1               5                   10                  15      


Gly Gly Tyr Cys Leu Thr Lys Trp Met Ile Leu Ala Ala Glu Leu Lys 
            20                  25                  30          


Cys Phe Gly Asn Thr Ala Val Ala Lys Cys Asn Val Asn His Asp Glu 
        35                  40                  45              


Glu Phe Cys Asp Met Leu Arg Leu Ile Asp Tyr Asn Lys Ala Ala Leu 
    50                  55                  60                  


Ser Lys Phe Lys Glu Asp Val Glu Ser Ala Leu His Leu Phe Lys Thr 
65                  70                  75                  80  


Thr Val Asn Ser Leu Ile Ser Asp Gln Leu Leu Met Arg Asn His Leu 
                85                  90                  95      


Arg Asp Leu Met Gly Val Pro Tyr Cys Asn Tyr Ser Lys Phe Trp Tyr 
            100                 105                 110         


Leu Glu His Ala Lys Thr Gly Glu Thr Ser Val Pro Lys Cys Trp Leu 
        115                 120                 125             


Val Thr Asn Gly Ser Tyr Leu Asn Glu Thr His Phe Ser Asp Gln Ile 
    130                 135                 140                 


Glu Gln Glu Ala Asp Asn Met Ile Thr Glu Met Leu Arg Lys Asp Tyr 
145                 150                 155                 160 


Ile Lys Arg Gln Gly 
                165 


<210>  20
<211>  1800
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Synthetic Polynucleotide

<400>  20
atgaagttat gcatattact ggccgtcgtg gcctttgttg gcctctcgct cgggatgtac       60

ggcctgaaag gacccgacat ttacaagggc gtgtaccagt ttaagagcgt ggaattcgac      120

atgtcccacc tgaacctgac catgcctaat gcctgctccg ccaataacag ccaccactat      180

atctccatgg ggacatccgg gctggagctg acattcacca acgacagcat cattagccac      240

aatttctgca acctgacaag cgccttcaac aaaaagacct tcgaccacac cctgatgagc      300

attgtgagca gcctgcacct gtccatcagg ggcaatagca attataaagc cgtgtcttgt      360

gatttcaaca atggcattac cattcagtac aacctgacat tctccgacgc ccagtctgcc      420

cagagccagt gtagaacatt ccgcggccgc gtgctggaca tgttccggac agccttcggc      480

ggaaagtata tgaggtcctg ctggggatgg acaggaagcg acgggaagac aacctggtgc      540

agccagacct cctaccagta cctgatcatc cagaatagaa cctgggagaa ccactgtaca      600

tatgccggcc ccttcggaat gtctaggatt ctgctgagcc aggagaagac caagtttctc      660

acaaggaggc gcagagggac ctttacatgg accctgtccg acagctctgg cgtggagaac      720

cccggcggat attgcctgac caagtggatg attctggccg ccgagctgaa gtgttttggc      780

aataccgccg tggccaagtg caacgtgaac cacgacgagg agttctgtga catgctgcgg      840

ctgatcgact acaataaggc cgccctgtcc aaattcaagc ctgacgtgga gtccgccctg      900

cacctgttta aaaccaccgt gaactctctg atctctgatc agctgctgat gaggaaccac      960

ctgagagacc tgatgtgtgt gccctactgt aattacagca aattctggta tctggagcac     1020

gccaagacag gcgagacaag cgtgccaaaa tgctggctgg tgaccaacgg ggcctatctg     1080

aatgagacac acttttccga ccagatcgag caggaagccg acaatatgat cacagagatg     1140

ctgaggaagg attatatcaa gcggcaggga ctcgagggtg gatcaccagt ggtcgaagtg     1200

cagggtacta ttgatgagct gaacagtttt ataggctatg cgcttgtgct gtcccgatgg     1260

gacgatattc gcaacgacct gtttcggatt cagaacgatc ttttcgtgct tggggaggat     1320

gtgagcaccg gtggcaaagg ccgaacggtt acaagagaga tgattgatta cctcgaagcc     1380

cgggtgaaag aaatgaaggc ggaaattggg aaaattgagc tcttcgtggt ccccgggggc     1440

agtgtggaat ctgcatcctt gcacatggcg agagctgttt ccagaaggct ggagaggagg     1500

atcgtggctg ccagcaaact gacagaaatc aataagaatg tcctgatata tgcaaatcgg     1560

ttgtcctcca ttctgttcat gcatgcactt attagtaaca agaggctgaa tatcccagag     1620

aaaatttggg cactcgaggt tgacgatgac gataaggccg gttggagtca tccacaattc     1680

gagaagggcg gcggctccgg aggtggatca ggaggtggtt cctggtcaca ccctcaattc     1740

gagaagggca gcggcggcct gaacgacatc ttcgaggccc agaagatcga gtggcacgag     1800


<210>  21
<211>  1362
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Synthetic Polynucleotide

<400>  21
atgaagttat gcatattact ggccgtcgtg gcctttgttg gcctctcgct cgggatgtac       60

ggcctgaaag gacccgacat ttacaagggc gtgtaccagt ttaagagcgt ggaattcgac      120

atgtcccacc tgaacctgac catgcctaat gcctgctccg ccaataacag ccaccactat      180

atctccatgg ggacatccgg gctggagctg acattcacca acgacagcat cattagccac      240

aatttctgca acctgacaag cgccttcaac aaaaagacct tcgaccacac cctgatgagc      300

attgtgagca gcctgcacct gtccatcagg ggcaatagca attataaagc cgtgtcttgt      360

gatttcaaca atggcattac cattcagtac aacctgacat tctccgacgc ccagtctgcc      420

cagagccagt gtagaacatt ccgcggccgc gtgctggaca tgttccggac agccttcggc      480

ggaaagtata tgaggtcctg ctggggatgg acaggaagcg acgggaagac aacctggtgc      540

agccagacct cctaccagta cctgatcatc cagaatagaa cctgggagaa ccactgtaca      600

tatgccggcc ccttcggaat gtctaggatt ctgctgagcc aggagaagac caagtttctc      660

acaaggaggc gcagagggac ctttacatgg accctgtccg acagctctgg cgtggagaac      720

cccggcggat attgcctgac caagtggatg attctggccg ccgagctgaa gtgttttggc      780

aataccgccg tggccaagtg caacgtgaac cacgacgagg agttctgtga catgctgcgg      840

ctgatcgact acaataaggc cgccctgtcc aaattcaagc ctgacgtgga gtccgccctg      900

cacctgttta aaaccaccgt gaactctctg atctctgatc agctgctgat gaggaaccac      960

ctgagagacc tgatgtgtgt gccctactgt aattacagca aattctggta tctggagcac     1020

gccaagacag gcgagacaag cgtgccaaaa tgctggctgg tgaccaacgg ggcctatctg     1080

aatgagacac acttttccga ccagatcgag caggaagccg acaatatgat cacagagatg     1140

ctgaggaagg attatatcaa gcggcaggga ggcggaagtc tcccagaaac aggactcgag     1200

gttgacgatg acgataaggc cggttggagt catccacaat tcgagaaggg cggcggctcc     1260

ggaggtggat caggaggtgg ttcctggtca caccctcaat tcgagaaggg cagcggcggc     1320

ctgaacgaca tcttcgaggc ccagaagatc gagtggcacg ag                        1362


<210>  22
<211>  372
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic Polypeptide

<400>  22

Met Tyr Gly Leu Lys Gly Pro Asp Ile Tyr Lys Gly Val Tyr Gln Phe 
1               5                   10                  15      


Lys Ser Val Glu Phe Asp Met Ser His Leu Asn Leu Thr Met Pro Asn 
            20                  25                  30          


Ala Cys Ser Ala Asn Asn Ser His His Tyr Ile Ser Met Gly Thr Ser 
        35                  40                  45              


Gly Leu Glu Leu Thr Phe Thr Asn Asp Ser Ile Ile Ser His Asn Phe 
    50                  55                  60                  


Cys Asn Leu Thr Ser Ala Phe Asn Lys Lys Thr Phe Asp His Thr Leu 
65                  70                  75                  80  


Met Ser Ile Val Ser Ser Leu His Leu Ser Ile Arg Gly Asn Ser Asn 
                85                  90                  95      


Tyr Lys Ala Val Ser Cys Asp Phe Asn Asn Gly Ile Thr Ile Gln Tyr 
            100                 105                 110         


Asn Leu Thr Phe Ser Asp Ala Gln Ser Ala Gln Ser Gln Cys Arg Thr 
        115                 120                 125             


Phe Arg Gly Arg Val Leu Asp Met Phe Arg Thr Ala Phe Gly Gly Lys 
    130                 135                 140                 


Tyr Met Arg Ser Gly Trp Gly Trp Thr Gly Ser Asp Gly Lys Thr Thr 
145                 150                 155                 160 


Trp Cys Ser Gln Thr Ser Tyr Gln Tyr Leu Ile Ile Gln Asn Arg Thr 
                165                 170                 175     


Trp Glu Asn His Cys Thr Tyr Ala Gly Pro Phe Gly Met Ser Arg Ile 
            180                 185                 190         


Leu Leu Ser Gln Glu Lys Thr Lys Phe Leu Thr Arg Arg Leu Ala Gly 
        195                 200                 205             


Thr Phe Thr Trp Thr Leu Ser Asp Ser Ser Gly Val Glu Asn Pro Gly 
    210                 215                 220                 


Gly Tyr Cys Leu Thr Lys Trp Met Ile Leu Ala Ala Glu Leu Lys Cys 
225                 230                 235                 240 


Phe Gly Asn Thr Ala Val Ala Lys Cys Asn Val Asn His Asp Glu Glu 
                245                 250                 255     


Phe Cys Asp Met Leu Arg Leu Ile Asp Tyr Asn Lys Ala Ala Leu Ser 
            260                 265                 270         


Lys Phe Lys Glu Asp Val Glu Ser Ala Leu His Leu Phe Lys Thr Thr 
        275                 280                 285             


Val Asn Ser Leu Ile Ser Asp Gln Leu Leu Met Arg Asn His Leu Arg 
    290                 295                 300                 


Asp Leu Met Gly Val Pro Tyr Cys Asn Tyr Ser Lys Phe Trp Tyr Leu 
305                 310                 315                 320 


Glu His Ala Lys Thr Gly Glu Thr Ser Val Pro Lys Cys Trp Leu Val 
                325                 330                 335     


Thr Asn Gly Ser Tyr Leu Asn Glu Thr His Phe Ser Asp Gln Ile Glu 
            340                 345                 350         


Gln Glu Ala Asp Asn Met Ile Thr Glu Met Leu Arg Lys Asp Tyr Ile 
        355                 360                 365             


Lys Arg Gln Gly 
    370         


<210>  23
<211>  498
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic Polypeptide

<400>  23

Met Gly Gln Ile Val Thr Met Phe Glu Ala Leu Pro His Ile Ile Asp 
1               5                   10                  15      


Glu Val Ile Asn Ile Val Ile Ile Val Leu Ile Val Ile Thr Gly Ile 
            20                  25                  30          


Lys Ala Val Tyr Asn Phe Ala Thr Cys Gly Ile Phe Ala Leu Ile Ser 
        35                  40                  45              


Phe Leu Leu Leu Ala Gly Arg Ser Cys Gly Met Tyr Gly Leu Lys Gly 
    50                  55                  60                  


Pro Asp Ile Tyr Lys Gly Val Tyr Gln Phe Lys Ser Val Glu Phe Asp 
65                  70                  75                  80  


Met Ser His Leu Asn Leu Thr Met Pro Asn Ala Cys Ser Ala Asn Asn 
                85                  90                  95      


Ser His His Tyr Ile Ser Met Gly Thr Ser Gly Leu Glu Leu Thr Phe 
            100                 105                 110         


Thr Asn Asp Ser Ile Ile Ser His Asn Phe Cys Asn Leu Thr Ser Ala 
        115                 120                 125             


Phe Asn Lys Lys Thr Phe Asp His Thr Leu Met Ser Ile Val Ser Ser 
    130                 135                 140                 


Leu His Leu Ser Ile Arg Gly Asn Ser Asn Tyr Lys Ala Val Ser Cys 
145                 150                 155                 160 


Asp Phe Asn Asn Gly Ile Thr Ile Gln Tyr Asn Leu Thr Phe Ser Asp 
                165                 170                 175     


Ala Gln Ser Ala Gln Ser Gln Cys Arg Thr Phe Arg Gly Arg Val Leu 
            180                 185                 190         


Asp Met Phe Arg Thr Ala Phe Gly Gly Lys Tyr Met Arg Ser Gly Trp 
        195                 200                 205             


Gly Trp Thr Gly Ser Asp Gly Lys Thr Thr Trp Cys Ser Gln Thr Ser 
    210                 215                 220                 


Tyr Gln Tyr Leu Ile Ile Gln Asn Arg Thr Trp Glu Asn His Cys Thr 
225                 230                 235                 240 


Tyr Ala Gly Pro Phe Gly Met Ser Arg Ile Leu Leu Ser Gln Glu Lys 
                245                 250                 255     


Thr Lys Phe Leu Thr Arg Arg Leu Ala Gly Thr Phe Thr Trp Thr Leu 
            260                 265                 270         


Ser Asp Ser Ser Gly Val Glu Asn Pro Gly Gly Tyr Cys Leu Thr Lys 
        275                 280                 285             


Trp Met Ile Leu Ala Ala Glu Leu Lys Cys Phe Gly Asn Thr Ala Val 
    290                 295                 300                 


Ala Lys Cys Asn Val Asn His Asp Glu Glu Phe Cys Asp Met Leu Arg 
305                 310                 315                 320 


Leu Ile Asp Tyr Asn Lys Ala Ala Leu Ser Lys Phe Lys Glu Asp Val 
                325                 330                 335     


Glu Ser Ala Leu His Leu Phe Lys Thr Thr Val Asn Ser Leu Ile Ser 
            340                 345                 350         


Asp Gln Leu Leu Met Arg Asn His Leu Arg Asp Leu Met Gly Val Pro 
        355                 360                 365             


Tyr Cys Asn Tyr Ser Lys Phe Trp Tyr Leu Glu His Ala Lys Thr Gly 
    370                 375                 380                 


Glu Thr Ser Val Pro Lys Cys Trp Leu Val Thr Asn Gly Ser Tyr Leu 
385                 390                 395                 400 


Asn Glu Thr His Phe Ser Asp Gln Ile Glu Gln Glu Ala Asp Asn Met 
                405                 410                 415     


Ile Thr Glu Met Leu Arg Lys Asp Tyr Ile Lys Arg Gln Gly Ser Thr 
            420                 425                 430         


Pro Leu Ala Leu Met Asp Leu Leu Met Phe Ser Thr Ser Ala Tyr Leu 
        435                 440                 445             


Val Ser Ile Phe Leu His Leu Val Lys Ile Pro Thr His Arg His Ile 
    450                 455                 460                 


Lys Gly Gly Ser Cys Pro Lys Pro His Arg Leu Thr Asn Lys Gly Ile 
465                 470                 475                 480 


Cys Ser Cys Gly Ala Phe Lys Val Pro Gly Val Lys Thr Val Trp Lys 
                485                 490                 495     


Arg Arg 
        


