                         SEQUENCE LISTING

<110>  CIVI BIOPHARMA, INC.
 
<120>  ORAL DELIVERY OF OLIGONUCLEOTIDES

<130>  4009.023PC03

<150>  63/288,379
<151>  2021-12-10
<150>  63/261,506
<151>  2021-09-22
<150>  63/178,361
<151>  2021-04-22

<160>  158   

<170>  PatentIn version 3.5

<210>  1
<211>  22
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Synthetic construct

<220>
<223>  1018 ISS

<400>  1
tgactgtgaa cgttcgagat ga                                                22


<210>  2
<211>  20
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Synthetic construct

<220>
<223>  Abetimus, subunit 1

<400>  2
gtgtgtgtgt gtgtgtgtgt                                                   20


<210>  3
<211>  20
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Synthetic construct

<220>
<223>  Abetimus, subunit 2

<400>  3
cacacacaca cacacacaca                                                   20


<210>  4
<211>  20
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Synthetic construct

<220>
<223>  Abetimus, subunit 3

<400>  4
cacacacaca cacacacaca                                                   20


<210>  5
<211>  20
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Synthetic construct

<220>
<223>  Abetimus, subunit 4

<400>  5
cacacacaca cacacacaca                                                   20


<210>  6
<211>  20
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Synthetic construct

<220>
<223>  Abetimus, subunit 5

<400>  6
cacacacaca cacacacaca                                                   20


<210>  7
<211>  20
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Synthetic construct

<220>
<223>  Abetimus, subunit 6

<400>  7
gtgtgtgtgt gtgtgtgtgt                                                   20


<210>  8
<211>  20
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Synthetic construct

<220>
<223>  Abetimus, subunit 7

<400>  8
gtgtgtgtgt gtgtgtgtgt                                                   20


<210>  9
<211>  20
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Synthetic construct

<220>
<223>  Abetimus, subunit 8

<400>  9
gtgtgtgtgt gtgtgtgtgt                                                   20


<210>  10
<211>  20
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Synthetic construct

<220>
<223>  Afovirsen

<400>  10
ttgcttccat cttcctcgtc                                                   20


<210>  11
<211>  25
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Synthetic construct

<220>
<223>  Aganirsen

<400>  11
tatccggagg gctcgccatg ctgct                                             25


<210>  12
<211>  24
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Synthetic construct

<220>
<223>  Agatolimod

<400>  12
tcgtcgtttt gtcgttttgt cgtt                                              24


<210>  13
<211>  20
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Synthetic construct

<220>
<223>  Alicaforsen

<400>  13
gcccaagctg gcatccgtca                                                   20


<210>  14
<211>  26
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Synthetic construct

<220>
<223>  AGRO100

<400>  14
ggtggtggtg gttgtggtgg tggtgg                                            26


<210>  15
<211>  20
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Synthetic construct

<220>
<223>  Amlivirsen

<400>  15
gcagaggtga agcgaagugc                                                   20


<210>  16
<211>  31
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Synthetic construct

<220>
<223>  Pegnivacigin

<400>  16
guggacuaua ccgcguaaug cugccuccac t                                      31


<210>  17
<211>  15
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Synthetic construct

<220>
<223>  Anivamersen

<400>  17
cgcgguauag uccac                                                        15


<210>  18
<211>  20
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Synthetic construct

<220>
<223>  Apatorsen

<400>  18
gggacgcggc gctcggucau                                                   20


<210>  19
<211>  26
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Synthetic construct

<220>
<223>  Aprinocarsen

<400>  19
ggtggtggtg gttgtggtgg tggtgg                                            26


<210>  20
<211>  17
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Synthetic construct

<220>
<223>  Zintevir

<400>  20
gtggtgggtg ggtgggt                                                      17


<210>  21
<211>  32
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Synthetic construct

<220>
<223>  ARC19499

<400>  21
ggaauauacu uggcucguua ggugcguaua ua                                     32


<210>  22
<211>  20
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Synthetic construct

<220>
<223>  Archexin

<400>  22
gctgcatgat ctccttggcg                                                   20


<210>  23
<211>  21
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Synthetic construct

<220>
<223>  Asvasiran antisense

<400>  23
cuugacuuug cuaagagcct t                                                 21


<210>  24
<211>  21
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Synthetic construct

<220>
<223>  Asvasiran sense

<400>  24
ggcucuuagc aaagucaagt t                                                 21


<210>  25
<211>  20
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Synthetic construct

<220>
<223>  Atesidorsen

<400>  25
ucagggcatt ctttccauuc                                                   20


<210>  26
<211>  23
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Synthetic construct

<220>
<223>  ATU-027 antisense

<400>  26
agacuugagg acuuccugga caa                                               23


<210>  27
<211>  23
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Synthetic construct

<220>
<223>  ATU-027 sense

<400>  27
uuguccagga aguccucaag ucu                                               23


<210>  28
<211>  39
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Synthetic construct

<220>
<223>  ZIMURA

<400>  28
cgccgcgguc ucaggcgcug agucugaguu uaccugcgt                              39


<210>  29
<211>  19
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Synthetic construct

<220>
<223>  AVI-7537

<400>  29
gccatggttt tttctcagg                                                    19


<210>  30
<211>  16
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Synthetic construct

<220>
<223>  Baliforsen

<400>  30
tcccgaatgt ccgaca                                                       16


<210>  31
<211>  21
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Synthetic construct

<220>
<223>  Bamosiran antisense

<400>  31
cauugugcau gugauccagt t                                                 21


<210>  32
<211>  21
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Synthetic construct

<220>
<223>  Bamosiran sense

<400>  32
cuggaucaca ugcacaaugt t                                                 21


<210>  33
<211>  18
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Synthetic construct

<220>
<223>  Bazlitoran

<400>  33
ctatctgucg ttctctgu                                                     18


<210>  34
<211>  16
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Synthetic construct

<220>
<223>  Beclanorsen

<400>  34
cucccaacgt gcgcca                                                       16


<210>  35
<211>  20
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Synthetic construct

<220>
<223>  Bepirovirsen

<400>  35
gcagaggtga agcgaagtgc                                                   20


<210>  36
<211>  21
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Synthetic construct

<220>
<223>  Bevasiranib antisense

<400>  36
accucaccaa ggccagcact t                                                 21


<210>  37
<211>  21
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Synthetic construct

<220>
<223>  Bevasiranib sense

<400>  37
gugcuggccu uggugaggut t                                                 21


<210>  38
<211>  23
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Synthetic construct

<220>
<223>  Brivoligide strand 1

<400>  38
ctacgcccac cgcccacgca tac                                               23


<210>  39
<211>  23
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Synthetic construct

<220>
<223>  Brivoligide strand 2

<400>  39
gtatgcgtgg gcggtgggcg tag                                               23


<210>  40
<211>  22
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Synthetic construct

<220>
<223>  Casimersen

<400>  40
caatgccatc ctggagttcc tg                                                22


<210>  41
<211>  24
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Synthetic construct

<220>
<223>  Cavrotolimod

<400>  41
tcgtcgtttt gtcgttttgt cgtt                                              24


<210>  42
<211>  25
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Synthetic construct

<220>
<223>  Cemdisiran antisense

<400>  42
uauuauaaaa auaucuugcu uuutt                                             25


<210>  43
<211>  22
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Synthetic construct

<220>
<223>  Cemdisiran sense

<220>
<221>  misc_feature
<222>  (22)..(22)
<223>  n is a, c, g, or u

<400>  43
aagcaagaua uuuuuauaau an                                                22


<210>  44
<211>  20
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Synthetic construct

<220>
<223>  Cenersen

<400>  44
ccctgctccc ccctggctcc                                                   20


<210>  45
<211>  19
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Synthetic construct

<220>
<223>  Cobitolimod

<400>  45
ggaacagttc gtccatggc                                                    19


<210>  46
<211>  30
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Synthetic construct

<220>
<223>  NEXAGON

<400>  46
gtaattgcgg caagaagaat tgtttctgtc                                        30


<210>  47
<211>  16
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Synthetic construct

<220>
<223>  Cofirasersen

<400>  47
cccgatagct ggtugu                                                       16


<210>  48
<211>  19
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Synthetic construct

<220>
<223>  Cosdosiran antisense

<400>  48
gccagaaugu ggaacuccu                                                    19


<210>  49
<211>  19
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Synthetic construct

<220>
<223>  Cosdosiran sense

<400>  49
aggaguucca cauucuggc                                                    19


<210>  50
<211>  21
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Synthetic construct

<220>
<223>  CPG-8954

<400>  50
gggggggtgt cgcagcaggg g                                                 21


<210>  51
<211>  20
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Synthetic construct

<220>
<223>  Cupabimod strand 1

<400>  51
ggagggaaat cccttcaagg                                                   20


<210>  52
<211>  20
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Synthetic construct

<220>
<223>  Cupabimod strand 2

<400>  52
ccttgaaggg atttccctcc                                                   20


<210>  53
<211>  21
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Synthetic construct

<220>
<223>  Custirsen

<400>  53
cagcagcaga gtcttcauca u                                                 21


<210>  54
<211>  16
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Synthetic construct

<220>
<223>  Danvatirsen

<400>  54
cuatttggat gtcagc                                                       16


<210>  55
<211>  21
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Synthetic construct

<220>
<223>  Daplusiran antisense

<400>  55
guggacuucu cucaauuuuc u                                                 21


<210>  56
<211>  21
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Synthetic construct

<220>
<223>  Daplusiran sense

<400>  56
agaaaauuga gagaagucca c                                                 21


<210>  57
<211>  25
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Synthetic construct

<220>
<223>  Dematirsen

<400>  57
guugccuccg guucugaagg uguuc                                             25


<210>  58
<211>  20
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Synthetic construct

<220>
<223>  Donidalorsen

<400>  58
tgcaagtctc ttggcaaaca                                                   20


<210>  59
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Synthetic construct

<220>
<223>  Drisapersen

<400>  59
ucaaggaaga uggcauuucu                                                   20


<210>  60
<211>  14
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Synthetic construct

<220>
<223>  Edifoligide strand 1

<400>  60
ctagatttcc cgcg                                                         14


<210>  61
<211>  14
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Synthetic construct

<220>
<223>  Edifoligide strand 2

<400>  61
gatccgcggg aaat                                                         14


<210>  62
<211>  40
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Synthetic construct

<220>
<223>  Egaptivon pegol

<400>  62
gcgugcagug ccuucggccg tgcggtgccu ccgucacgct                             40


<210>  63
<211>  20
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Synthetic construct

<220>
<223>  EIF-4E

<400>  63
tgttatattc ctggatcctt                                                   20


<210>  64
<211>  33
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Synthetic construct

<220>
<223>  Eluforsen

<400>  64
aucauaggaa acaccaaaga ugauauuuuc uuu                                    33


<210>  65
<211>  40
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Synthetic construct

<220>
<223>  Emapticap pegol

<400>  65
gcacgucccu caccggugca agugaagccg uggcucugcg                             40


<210>  66
<211>  20
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Synthetic construct

<220>
<223>  Eplontersen

<400>  66
ucuuggttac atgaaauccc                                                   20


<210>  67
<211>  30
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Synthetic construct

<220>
<223>  Eteplirsen

<400>  67
ctccaacatc aaggaagatg gcatttctag                                        30


<210>  68
<211>  20
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Synthetic construct

<220>
<223>  Fesomersen

<400>  68
acggcattgg tgcacaguuu                                                   20


<210>  69
<211>  23
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Synthetic construct

<220>
<223>  Fitusiran antisense

<400>  69
uugaaguaaa ugguguuaac cag                                               23


<210>  70
<211>  21
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Synthetic construct

<220>
<223>  Fitusiran sense

<400>  70
gguuaacacc auuuacuuca a                                                 21


<210>  71
<211>  21
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Synthetic construct

<220>
<223>  Fomivirsen

<400>  71
gcgtttgctc ttcttcttgc g                                                 21


<210>  72
<211>  18
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Synthetic construct

<220>
<223>  Gataparsen

<400>  72
tgtgctattc tgtgaatt                                                     18


<210>  73
<211>  23
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Synthetic construct

<220>
<223>  Givosiran antisense

<400>  73
aaugaugaga cacucuuucu ggu                                               23


<210>  74
<211>  21
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Synthetic construct

<220>
<223>  Givosiran sense

<400>  74
cagaaagagu gucucaucuu a                                                 21


<210>  75
<211>  21
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Synthetic construct

<220>
<223>  GNKG-168

<400>  75
tcgtcgacgt cgttcgttct c                                                 21


<210>  76
<211>  25
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Synthetic construct

<220>
<223>  Golodirsen

<400>  76
gttgcctccg gttctgaagg tgttc                                             25


<210>  77
<211>  20
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Synthetic construct

<220>
<223>  GPI-2A

<400>  77
ggttcttttg gtccttgtct                                                   20


<210>  78
<211>  20
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Synthetic construct

<220>
<223>  GTI-2040

<400>  78
ggctaaatcg ctccaccaag                                                   20


<210>  79
<211>  20
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Synthetic construct

<220>
<223>  GTI-2501

<400>  79
ctctagcgtc ttaaagccga                                                   20


<210>  80
<211>  24
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Synthetic construct

<220>
<223>  IMT-504

<400>  80
tcatcatttt gtcattttgt catt                                              24


<210>  81
<211>  22
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Synthetic construct

<220>
<223>  Inclisiran antisense

<220>
<221>  misc_feature
<222>  (22)..(22)
<223>  n is a, c, g, t or u

<400>  81
cuagaccugu tuugcuuuug un                                                22


<210>  82
<211>  23
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Synthetic construct

<220>
<223>  Inclisiran sense

<400>  82
acaaaagcaa aacaggucua gaa                                               23


<210>  83
<211>  20
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Synthetic construct

<220>
<223>  Inotersen

<400>  83
ucuuggttac atgaaauccc                                                   20


<210>  84
<211>  13
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Synthetic construct

<220>
<223>  Imetelstat

<400>  84
tagggttaga caa                                                          13


<210>  85
<211>  19
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Synthetic construct

<220>
<223>  Lademirsen

<400>  85
acatcagtct gauaagcta                                                    19


<210>  86
<211>  44
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Synthetic construct

<220>
<223>  Lexaptepid pegol

<400>  86
gcgccguaug ggauuaagua aaugaggagu uggaggaagg gcgc                        44


<210>  87
<211>  26
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Synthetic construct

<220>
<223>  Litenimod

<400>  87
taaacgttat aacgttatga cgtcat                                            26


<210>  88
<211>  21
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Synthetic construct

<220>
<223>  Lumasiran antisense

<400>  88
gacuuucauc cuggaaauau a                                                 21


<210>  89
<211>  23
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Synthetic construct

<220>
<223>  Lumasiran sense

<400>  89
uauauuucca ggaugaaagu cca                                               23


<210>  90
<211>  20
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Synthetic construct

<220>
<223>  Mipomersen

<400>  90
gccucagtct gcttcgcacc                                                   20


<210>  91
<211>  15
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Synthetic construct

<220>
<223>  Miravirsen

<400>  91
ccattgtcac actcc                                                        15


<210>  92
<211>  21
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Synthetic construct

<220>
<223>  Mongersen

<400>  92
gtcgcccctt ctccccgcag c                                                 21


<210>  93
<211>  22
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Synthetic construct

<220>
<223>  Nedosiran antisense

<400>  93
ucagauaaaa aggacaacau gg                                                22


<210>  94
<211>  36
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Synthetic construct

<220>
<223>  Nedosiran sense

<400>  94
auguuguccu uuuuaucuga gcagccgaaa ggcugc                                 36


<210>  95
<211>  18
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Synthetic construct

<220>
<223>  Nusinersen

<400>  95
tcacctttat aatgctgg                                                     18


<210>  96
<211>  18
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Synthetic construct

<220>
<223>  Oblimersen

<400>  96
tctcccagcg tgcgccat                                                     18


<210>  97
<211>  45
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Synthetic construct

<220>
<223>  Olaptesed pegol

<400>  97
gcguggugug aucuagaugu auuggcugau ccuagucagg uacgc                       45


<210>  98
<211>  21
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Synthetic construct

<220>
<223>  Olpasiran antisense

<400>  98
cagccccuua uuguuauacg a                                                 21


<210>  99
<211>  21
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Synthetic construct

<220>
<223>  Olpasiran sense

<400>  99
ucguauaaca auaaggggcu g                                                 21


<210>  100
<211>  21
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Synthetic construct

<220>
<223>  Patisiran antisense

<400>  100
guaaccaaga guauuccaut t                                                 21


<210>  101
<211>  21
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Synthetic construct

<220>
<223>  Patisiran sense

<400>  101
auggaauacu cuugguuact t                                                 21


<210>  102
<211>  28
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Synthetic construct

<220>
<223>  Pegaptanib

<400>  102
cggaaucagu gaaugcuuau acauccgt                                          28


<210>  103
<211>  30
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Synthetic construct

<220>
<223>  Pegpleranib

<400>  103
caggcuacgc gtagagcauc atgatccugt                                        30


<210>  104
<211>  20
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Synthetic construct

<220>
<223>  Pelacarsen

<400>  104
tgctccgttg gtgcttgttc                                                   20


<210>  105
<211>  18
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Synthetic construct

<220>
<223>  Prexigebersen

<400>  105
atatttggcg atggcttc                                                     18


<210>  106
<211>  30
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Synthetic construct

<220>
<223>  Radavirsen

<400>  106
ctccaacatc aaggaagatg gcatttctag                                        30


<210>  107
<211>  25
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Synthetic construct

<220>
<223>  Remlarsen antisense

<400>  107
uagcaccauu ugaaaucagu guuuu                                             25


<210>  108
<211>  23
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Synthetic construct

<220>
<223>  Remlarsen sense

<400>  108
aacacuguuu acaaaugguc cua                                               23


<210>  109
<211>  18
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Synthetic construct

<220>
<223>  Renadirsen

<400>  109
ccuaccguaa cccgucgc                                                     18


<210>  110
<211>  20
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Synthetic construct

<220>
<223>  Resten-MP

<400>  110
acgttgaggg gcatcgtcgc                                                   20


<210>  111
<211>  21
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Synthetic construct

<220>
<223>  Revusiran antisense

<400>  111
ugggauuuca uguaaccaag a                                                 21


<210>  112
<211>  23
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Synthetic construct

<220>
<223>  Revusiran sense

<400>  112
ucuugguuac augaaauccc auc                                               23


<210>  113
<211>  9
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Synthetic construct

<220>
<223>  RGLS-4326

<400>  113
agcacuuug                                                                9


<210>  114
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Synthetic construct

<220>
<223>  Rimigorsen

<400>  114
ucagcuucug uuagccacug                                                   20


<210>  115
<211>  24
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Synthetic construct

<220>
<223>  Rosomidnar

<400>  115
cacgcacgcg catccccgcc cgtg                                              24


<210>  116
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Synthetic construct

<220>
<223>  Suvodirsen

<400>  116
ucaaggaaga uggcauuucu                                                   20


<210>  117
<211>  19
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Synthetic construct

<220>
<223>  Temavirsen

<400>  117
acaccautgu cacactcca                                                    19


<210>  118
<211>  19
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Synthetic construct

<220>
<223>  Teprasiran antisense

<400>  118
ugaaggguga aauauucuc                                                    19


<210>  119
<211>  19
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Synthetic construct

<220>
<223>  Teprasiran sense

<400>  119
gagaauauuu cacccuuca                                                    19


<210>  120
<211>  19
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Synthetic construct

<220>
<223>  Tivanisiran antisense

<400>  120
aagcgcaucu ucuacuuca                                                    19


<210>  121
<211>  19
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Synthetic construct

<220>
<223>  Tivanisiran sense

<400>  121
ugaaguagaa gaugcgcuu                                                    19


<210>  122
<211>  20
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Synthetic construct

<220>
<223>  Tofersen

<400>  122
caggatacat ttctacagcu                                                   20


<210>  123
<211>  20
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Synthetic construct

<220>
<223>  Tominersen

<400>  123
cucagtaaca ttgacaccac                                                   20


<210>  124
<211>  18
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Synthetic construct

<220>
<223>  Trabedersen

<400>  124
cggcatgtct attttgta                                                     18


<210>  125
<211>  25
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Synthetic construct

<220>
<223>  Trecovirsen

<400>  125
tcttcctctc tctacccacg ctctc                                             25


<210>  126
<211>  30
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Synthetic construct

<220>
<223>  Vidutolimod

<400>  126
gggggggggg gacgatcgtc gggggggggg                                        30


<210>  127
<211>  21
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Synthetic construct

<220>
<223>  Viltolarsen

<400>  127
cctccggttc tgaaggtgtt c                                                 21


<210>  128
<211>  20
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Synthetic construct

<220>
<223>  Volanesorsen

<400>  128
agcuucttgt ccagcuuuau                                                   20


<210>  129
<211>  20
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Synthetic construct

<220>
<223>  Vupanorsen

<400>  129
ggacattgcc agtaatcgca                                                   20


<210>  130
<211>  21
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Synthetic construct

<220>
<223>  Vutrisiran antisense

<400>  130
ugggauuuca uguaaccaag a                                                 21


<210>  131
<211>  23
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Synthetic construct

<220>
<223>  Vutrisiran sense

<400>  131
ucuugguuac augaaauccc auc                                               23


<210>  132
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Synthetic construct

<220>
<223>  Rovanersen

<400>  132
ggcacaaggg cacagacuuc                                                   20


<210>  133
<211>  20
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Synthetic construct

<220>
<223>  Lexanersen

<400>  133
gugcacacag tagatgaggg                                                   20


<210>  134
<211>  16
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Synthetic construct

<220>
<223>  Cepadacursen (CIVI 008)

<400>  134
aatgctacaa aaccca                                                       16


<210>  135
<211>  16
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Synthetic construct

<220>
<223>  ISIS-863633

<400>  135
aataatctca tgtcag                                                       16


<210>  136
<211>  19
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Synthetic construct

<220>
<223>  AEG35156

<400>  136
ugcaccctgg ataccauuu                                                    19


<210>  137
<211>  26
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Synthetic construct

<220>
<223>  AS1411

<400>  137
ggtggtggtg gttgtggtgg tggtgg                                            26


<210>  138
<211>  22
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Synthetic construct

<220>
<223>  Belcesiran antisense

<400>  138
uuuaagaaga caaaggguuu gg                                                22


<210>  139
<211>  36
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Synthetic construct

<220>
<223>  Belcesiran sense

<400>  139
aaacccuuug ucuucuuaaa gcagccgaaa ggcugc                                 36


<210>  140
<211>  20
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Synthetic construct

<220>
<223>  Cimderlirsen

<400>  140
ccacctttgg gtgaatagca                                                   20


<210>  141
<211>  16
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Synthetic construct

<220>
<223>  Frenlosirsen

<400>  141
agttgtaaat gagucg                                                       16


<210>  142
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Synthetic construct

<220>
<223>  LSP-GR3

<400>  142
gcuagguuua cgggaccucu                                                   20


<210>  143
<211>  20
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Synthetic construct

<220>
<223>  Monarsen

<400>  143
ctgcgatatt ttcttgtacc                                                   20


<210>  144
<211>  20
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Synthetic construct

<220>
<223>  Olezarsen

<400>  144
agcuucttgt ccagcuuuau                                                   20


<210>  145
<211>  25
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Synthetic construct

<220>
<223>  PUL-042

<400>  145
tcgtcgtcgt tcgaacgacg ttgat                                             25


<210>  146
<211>  20
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Synthetic construct

<220>
<223>  Sapablursen

<400>  146
cuuuattcca aagggcagcu                                                   20


<210>  147
<211>  17
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Synthetic construct

<220>
<223>  Sepofarsen

<400>  147
gguggaucac gaguuca                                                      17


<210>  148
<211>  18
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Synthetic construct

<220>
<223>  Tadnersen

<400>  148
gcccctagcg cgcgacuc                                                     18


<210>  149
<211>  11
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Synthetic construct

<220>
<223>  Tilsotolimod chain 1

<400>  149
tcgaacgttc g                                                            11


<210>  150
<211>  11
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Synthetic construct

<220>
<223>  Tilsotolimod chain 2

<400>  150
tcgaacgttc g                                                            11


<210>  151
<211>  21
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Synthetic construct

<220>
<223>  Tomligisiran antisense

<400>  151
uaccaauuua ugccuacagc g                                                 21


<210>  152
<211>  21
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Synthetic construct

<220>
<223>  Tomligisiran sense

<400>  152
cgcuguaggc auaaauuggu a                                                 21


<210>  153
<211>  21
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Synthetic construct

<220>
<223>  TOP-1731

<400>  153
tcatgagtgg cagctgcaat t                                                 21


<210>  154
<211>  25
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Synthetic construct

<220>
<223>  Varodarsen

<400>  154
uuugccgcug cccaaugcca uccug                                             25


<210>  155
<211>  21
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Synthetic construct

<220>
<223>  VEGLIN3

<400>  155
tggcttgaag atgtactcga t                                                 21


<210>  156
<211>  23
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Synthetic construct

<220>
<223>  Zilebesiran antisense

<400>  156
uguacucuca uuguggauga cga                                               23


<210>  157
<211>  21
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Synthetic construct

<220>
<223>  Zilebesiran sense

<400>  157
gucauccaca augagaguac a                                                 21


<210>  158
<211>  13
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Synthetic construct

<220>
<223>  Factor VII ASO

<400>  158
gcaccacggt cca                                                          13


