
                                SEQUENCE LISTING

<110> Hempstead, Barbara
      Lee, Francis
      Smith, Roshelle
      Danelon, Victor
      Almo, Steven
      Morano, Nicholas
      Garrett, Sarah
      Cornell University
      Albert Einstein College of Medicine
      

<120> The  immunomodulatory ligand B7-1 mediates synaptic
      remodeling by p75NTR
  
  

<130> 1676.175WO1

<150> US 63/178,163       
<151> 2021-04-22  

<160> 12

<170> FastSEQ for Windows Version 4.0

<210> 1
<211> 280
<212> PRT
<213> Homo sapiens

<400> 1
Met Gly His Thr Arg Arg Gln Gly Thr Ser Pro Ser Lys Cys Pro Tyr
 1               5                  10                  15
Leu Asn Phe Phe Gln Leu Leu Val Leu Ala Gly Leu Ser His Phe Cys
            20                  25                  30
Ser Gly Val Ile His Val Thr Tyr Glu Val Lys Glu Val Ala Thr Leu
        35                  40                  45
Ser Cys Gly His Asn Val Ser Val Glu Glu Leu Ala Gln Thr Arg Ile
    50                  55                  60
Tyr Trp Gln Lys Glu Lys Lys Met Val Leu Thr Met Met Ser Gly Asp
65                  70                  75                  80
Met Asn Ile Trp Pro Glu Tyr Lys Asn Arg Thr Ile Phe Asp Ile Thr
                85                  90                  95
Asn Asn Leu Ser Ile Val Ile Leu Ala Leu Arg Pro Ser Asp Glu Gly
            100                 105                 110
Thr Tyr Glu Cys Val Val Leu Lys Tyr Glu Lys Asp Ala Phe Lys Arg
        115                 120                 125
Glu His Leu Ala Glu Val Thr Leu Ser Val Lys Ala Asp Phe Pro Thr
    130                 135                 140
Pro Ser Ile Ser Asp Phe Glu Ile Pro Thr Ser Asn Ile Arg Arg Ile
145                 150                 155                 160
Ile Cys Ser Thr Ser Gly Gly Phe Pro Glu Pro His Leu Ser Trp Leu
                165                 170                 175
Glu Asn Gly Glu Glu Leu Asn Ala Ile Asn Thr Thr Val Ser Gln Asp
            180                 185                 190
Pro Glu Thr Glu Leu Tyr Ala Val Ser Ser Lys Leu Asp Phe Asn Met
        195                 200                 205
Thr Thr Asn His Ser Phe Met Cys Leu Ile Lys Tyr Gly His Leu Arg
    210                 215                 220
Val Asn Gln Thr Phe Asn Trp Asn Thr Thr Lys Gln Glu His Phe Pro
225                 230                 235                 240
Asp Asn Leu Leu Pro Ser Trp Ala Ile Thr Leu Ile Ser Val Asn Gly
                245                 250                 255
Ile Phe Val Ile Cys Cys Leu Thr Tyr Cys Phe Ala Pro Arg Cys Arg
            260                 265                 270
Glu Arg Arg Arg Asn Glu Arg Leu
        275                 280

<210> 2
<211> 18
<212> PRT
<213> Homo sapiens

<400> 2
Leu Leu Pro Ser Trp Ala Ile Thr Leu Ile Ser Val Asn Gly Ile Phe
 1               5                  10                  15
Val Ile


<210> 3
<211> 288
<212> PRT
<213> Homo sapiens

<400> 3
Met Gly His Thr Arg Arg Gln Gly Thr Ser Pro Ser Lys Cys Pro Tyr
 1               5                  10                  15
Leu Asn Phe Phe Gln Leu Leu Val Leu Ala Gly Leu Ser His Phe Cys
            20                  25                  30
Ser Gly Val Ile His Val Thr Lys Glu Val Lys Glu Val Ala Thr Leu
        35                  40                  45
Ser Cys Gly His Asn Val Ser Val Glu Glu Leu Ala Gln Thr Arg Ile
    50                  55                  60
Tyr Trp Gln Lys Glu Lys Lys Met Val Leu Thr Met Met Ser Gly Asp
65                  70                  75                  80
Met Asn Ile Trp Pro Glu Tyr Lys Asn Arg Thr Ile Phe Asp Ile Thr
                85                  90                  95
Asn Asn Leu Ser Ile Val Ile Leu Ala Leu Arg Pro Ser Asp Glu Gly
            100                 105                 110
Thr Tyr Glu Cys Val Val Leu Lys Tyr Glu Lys Asp Ala Phe Lys Arg
        115                 120                 125
Glu His Leu Ala Glu Val Thr Leu Ser Val Lys Ala Asp Phe Pro Thr
    130                 135                 140
Pro Ser Ile Ser Asp Phe Glu Ile Pro Thr Ser Asn Ile Arg Arg Ile
145                 150                 155                 160
Ile Cys Ser Thr Ser Gly Gly Phe Pro Glu Pro His Leu Ser Trp Leu
                165                 170                 175
Glu Asn Gly Glu Glu Leu Asn Ala Ile Asn Thr Thr Val Ser Gln Asp
            180                 185                 190
Pro Glu Thr Glu Leu Tyr Ala Val Ser Ser Lys Leu Asp Phe Asn Met
        195                 200                 205
Thr Thr Asn His Ser Phe Met Cys Leu Ile Lys Tyr Gly His Leu Arg
    210                 215                 220
Val Asn Gln Thr Phe Asn Trp Asn Thr Thr Lys Gln Glu His Phe Pro
225                 230                 235                 240
Asp Asn Leu Leu Pro Ser Trp Ala Ile Thr Leu Ile Ser Val Asn Gly
                245                 250                 255
Ile Phe Val Ile Cys Cys Leu Thr Tyr Cys Phe Ala Pro Arg Cys Arg
            260                 265                 270
Glu Arg Arg Arg Asn Glu Arg Leu Arg Arg Glu Ser Val Arg Pro Val
        275                 280                 285

<210> 4
<211> 2737
<212> DNA
<213> Homo sapiens

<400> 4
aaaccctctg taaagtaaca gaagttagaa ggggaaatgt cgcctctctg aagattaccc      60
aaagaaaaag tgatttgtca ttgctttata gactgtaaga agagaacatc tcagaagtgg     120
agtcttaccc tgaaatcaaa ggatttaaag aaaaagtgga atttttcttc agcaagctgt     180
gaaactaaat ccacaacctt tggagaccca ggaacaccct ccaatctctg tgtgttttgt     240
aaacatcact ggagggtctt ctacgtgagc aattggattg tcatcagccc tgcctgtttt     300
gcacctggga agtgccctgg tcttacttgg gtccaaattg ttggctttca cttttgaccc     360
taagcatctg aagccatggg ccacacacgg aggcagggaa catcaccatc caagtgtcca     420
tacctcaatt tctttcagct cttggtgctg gctggtcttt ctcacttctg ttcaggtgtt     480
atccacgtga ccaaggaagt gaaagaagtg gcaacgctgt cctgtggtca caatgtttct     540
gttgaagagc tggcacaaac tcgcatctac tggcaaaagg agaagaaaat ggtgctgact     600
atgatgtctg gggacatgaa tatatggccc gagtacaaga accggaccat ctttgatatc     660
actaataacc tctccattgt gatcctggct ctgcgcccat ctgacgaggg cacatacgag     720
tgtgttgttc tgaagtatga aaaagacgct ttcaagcggg aacacctggc tgaagtgacg     780
ttatcagtca aagctgactt ccctacacct agtatatctg actttgaaat tccaacttct     840
aatattagaa ggataatttg ctcaacctct ggaggttttc cagagcctca cctctcctgg     900
ttggaaaatg gagaagaatt aaatgccatc aacacaacag tttcccaaga tcctgaaact     960
gagctctatg ctgttagcag caaactggat ttcaatatga caaccaacca cagcttcatg    1020
tgtctcatca agtatggaca tttaagagtg aatcagacct tcaactggaa tacaaccaag    1080
caagagcatt ttcctgataa cctgctccca tcctgggcca ttaccttaat ctcagtaaat    1140
ggaatttttg tgatatgctg cctgacctac tgctttgccc caagatgcag agagagaagg    1200
aggaatgaga gattgagaag ggaaagtgta cgccctgtat aacagtgtcc gcagaagcaa    1260
ggggctgaaa agatctgaag gtcccacctc catttgcaat tgacctcttc tgggaacttc    1320
ctcagatgga caagattacc ccaccttgcc ctttacgtat ctgctcttag gtgcttcttc    1380
acttcagttg ctttgcagga agtgtctaga ggaatatggt gggcacagaa gtagctctgg    1440
tgaccttgat caaggtgttt tgaaatgcag aattcttgag ttctggaagg gactttagag    1500
aataccagtg ttattaatga caaaggcact gaggcccagg gaggtgaccc gaattataaa    1560
ggccagcgcc agaacccaga tttcctaact ctggtgctct ttccctttat cagtttgact    1620
gtggcctgtt aactggtata tacatatata tgtcaggcaa agtgctgctg gaagtagaat    1680
ttgtccaata acaggtcaac ttcagagact atctgatttc ctaatgtcag agtagaagat    1740
tttatgctgc tgtttacaaa agcccaatgt aatgcatagg aagtatggca tgaacatctt    1800
taggagacta atggaaatat tattggtgtt tacccagtat tccatttttt tcattgtgtt    1860
ctctattgct gctctctcac tcccccatga ggtacagcag aaaggagaac tatccaaaac    1920
taatttcctc tgacatgtaa gacgaatgat ttaggtacgt caaagcagta gtcaaggagg    1980
aaagggatag tccaaagact taactggttc atattggact gataatctct ttaaatggct    2040
ttatgctagt ttgacctcat ttgtaaaata tttatgagaa agttctcatt taaaatgaga    2100
tcgttgttta cagtgtatgt actaagcagt aagctatctt caaatgtcta aggtagtaac    2160
tttccatagg gcctccttag atccctaaga tggctttttc tccttggtat ttctgggtct    2220
ttctgacatc agcagagaac tggaaagaca tagccaactg ctgttcatgt tactcatgac    2280
tcctttctct aaaactgcct tccacaattc actagaccag aagtggacgc aacttaagct    2340
gggataatca cattatcatc tgaaaatctg gagttgaaca gcaaaagaag acaacatttc    2400
tcaaatgcac atctcatggc agctaagcca catggctggg atttaaagcc tttagagcca    2460
gcccatggct ttagctacct cactatgctg cttcacaaac cttgctcctg tgtaaaacta    2520
tattctcagt gtagggcaga gaggtctaac accaacataa ggtactagca gtgtttcccg    2580
tattgacagg aatacttaac tcaataattc ttttcttttc catttagtaa cagttgtgat    2640
gactatgttt ctattctaag taattcctgt attctacagc agatactttg tcagcaatac    2700
taagggaaga aacaaagttg aaccgtttct ttaataa                             2737

<210> 5
<211> 306
<212> PRT
<213> Mus musculus

<400> 5
Met Ala Cys Asn Cys Gln Leu Met Gln Asp Thr Pro Leu Leu Lys Phe
 1               5                  10                  15
Pro Cys Pro Arg Leu Ile Leu Leu Phe Val Leu Leu Ile Arg Leu Ser
            20                  25                  30
Gln Val Ser Ser Asp Val Asp Glu Gln Leu Ser Lys Ser Val Lys Asp
        35                  40                  45
Lys Val Leu Leu Pro Cys Arg Tyr Asn Ser Pro His Glu Asp Glu Ser
    50                  55                  60
Glu Asp Arg Ile Tyr Trp Gln Lys His Asp Lys Val Val Leu Ser Val
65                  70                  75                  80
Ile Ala Gly Lys Leu Lys Val Trp Pro Glu Tyr Lys Asn Arg Thr Leu
                85                  90                  95
Tyr Asp Asn Thr Thr Tyr Ser Leu Ile Ile Leu Gly Leu Val Leu Ser
            100                 105                 110
Asp Arg Gly Thr Tyr Ser Cys Val Val Gln Lys Lys Glu Arg Gly Thr
        115                 120                 125
Tyr Glu Val Lys His Leu Ala Leu Val Lys Leu Ser Ile Lys Ala Asp
    130                 135                 140
Phe Ser Thr Pro Asn Ile Thr Glu Ser Gly Asn Pro Ser Ala Asp Thr
145                 150                 155                 160
Lys Arg Ile Thr Cys Phe Ala Ser Gly Gly Phe Pro Lys Pro Arg Phe
                165                 170                 175
Ser Trp Leu Glu Asn Gly Arg Glu Leu Pro Gly Ile Asn Thr Thr Ile
            180                 185                 190
Ser Gln Asp Pro Glu Ser Glu Leu Tyr Thr Ile Ser Ser Gln Leu Asp
        195                 200                 205
Phe Asn Thr Thr Arg Asn His Thr Ile Lys Cys Leu Ile Lys Tyr Gly
    210                 215                 220
Asp Ala His Val Ser Glu Asp Phe Thr Trp Glu Lys Pro Pro Glu Asp
225                 230                 235                 240
Pro Pro Asp Ser Lys Asn Thr Leu Val Leu Phe Gly Ala Gly Phe Gly
                245                 250                 255
Ala Val Ile Thr Val Val Val Ile Val Val Ile Ile Lys Cys Phe Cys
            260                 265                 270
Lys His Arg Ser Cys Phe Arg Arg Asn Glu Ala Ser Arg Glu Thr Asn
        275                 280                 285
Asn Ser Leu Thr Phe Gly Pro Glu Glu Ala Leu Ala Glu Gln Thr Val
    290                 295                 300
Phe Leu
305

<210> 6
<211> 2688
<212> DNA
<213> Mus musculus

<400> 6
gagttttata cctcaataga ctcttactag tttctctttt tcaggttgtg aaactcaacc      60
ttcaaagaca ctctgttcca tttctgtgga ctaataggat catctttagc atctgccggg     120
tggatgccat ccaggcttct ttttctacat ctctgtttct cgatttttgt gagcctagga     180
ggtgcctaag ctccattggc tctagattcc tggctttccc catcatgttc tccaaagcat     240
ctgaagctat ggcttgcaat tgtcagttga tgcaggatac accactcctc aagtttccat     300
gtccaaggct cattcttctc tttgtgctgc tgattcgtct ttcacaagtg tcttcagatg     360
ttgatgaaca actgtccaag tcagtgaaag ataaggtatt gctgccttgc cgttacaact     420
ctcctcatga agatgagtct gaagaccgaa tctactggca aaaacatgac aaagtggtgc     480
tgtctgtcat tgctgggaaa ctaaaagtgt ggcccgagta taagaaccgg actttatatg     540
acaacactac ctactctctt atcatcctgg gcctggtcct ttcagaccgg ggcacataca     600
gctgtgtcgt tcaaaagaag gaaagaggaa cgtatgaagt taaacacttg gctttagtaa     660
agttgtccat caaagctgac ttctctaccc ccaacataac tgagtctgga aacccatctg     720
cagacactaa aaggattacc tgctttgctt ccgggggttt cccaaagcct cgcttctctt     780
ggttggaaaa tggaagagaa ttacctggca tcaatacgac aatttcccag gatcctgaat     840
ctgaattgta caccattagt agccaactag atttcaatac gactcgcaac cacaccatta     900
agtgtctcat taaatatgga gatgctcacg tgtcagagga cttcacctgg gaaaaacccc     960
cagaagaccc tcctgatagc aagaacacac ttgtgctctt tggggcagga ttcggcgcag    1020
taataacagt cgtcgtcatc gttgtcatca tcaaatgctt ctgtaagcac agaagctgtt    1080
tcagaagaaa tgaggcaagc agagaaacaa acaacagcct taccttcggg cctgaagaag    1140
cattagctga acagaccgtc ttcctttagt tcttctctgt ccatgtggga tacatggtat    1200
tatgtggctc atgaggtctc atctaccatt tgcaactgac ctcttctgca aaggacttca    1260
gaaacctagc actaccctgg ctctgcaaac acggttctct aggtgaagcc tctgcagtgg    1320
tttgcagaag tactcagacg aatgaaccac agtagttctg ctgattctga ggacgtagtt    1380
tagagactga attctttgga aaggacatag ggacgatttg cacatttgct tgcacatcac    1440
acacacacac acacacacac acacacacac acccacacac acacactctc tctcgatacc    1500
ttaggatagg gttctaccct gttgctcagt gacaaagaat cactctgtgg cggaggcagg    1560
cttcaagctt gcagcaatcc tcctgcacca gtttcctgag tgccagactt ccaggtgtaa    1620
gctatggcac ttagcagaac actagctgaa tcaatgaaga cactgaggtt ccaagaggga    1680
acctgaatta tgaaggtgag tcagaatcca gatttcctgg ctctaccact cttaacctgt    1740
atctgttaga ccccaagctc tgagctcata gacaagctaa tttaaaatgc ttttaataag    1800
cagaaggctc agttagtacg gggttcagga tactgcttac tggcaatatt tgactagcct    1860
ctattttgtt tgttttttaa ggcctactga ctgtagtgta atttgtagga aacatgttgc    1920
tatgtatacc catttgaggg taataaaaat gttggtaatt ttcagccagc actttccagg    1980
tatttccctt tttatccttc atgtccttaa aagaaaccag agtcaaccag aattaactgc    2040
ttttgttgtc taagatgaat gtatgccttt tatacttcaa agcaaaagtc aagttggagg    2100
cacagttcgt aacttactcg ttcatattga acttataatg aatgtcttta ggcaactttg    2160
cccttttaca cagttcttga tatagttctt atttcaaatg agattattta ctgagtaatc    2220
atctgtcctc acataaacaa cttaagtgat actagcctta cacagaactt cctcagattc    2280
ctggaagtgg cttttgctct ttggtataga tctgctacag tggaattgaa aaataaaatg    2340
tacgttagac acacttgcct gtaatccctg cactcagtat actgaggctg aagaactgaa    2400
ttccaggtag catggcctgg atagtaagat cctgtctgaa acccactcct ccatcaatgt    2460
gccccaaaga aatggaaaac aagaagcagc taactgctgc ttctatactg aaggttccct    2520
tttctctgag atgtaatcca caacctacaa gaccagcagt gagcttaagt caagacaatc    2580
agatattcta gtctgaattt ataggaggac atcgaatggc agccaaactt ctcaacggga    2640
ccagaatctg ttgtatgccc aggaaacagg tccattttta tgtgggtg                 2688

<210> 7
<211> 306
<212> PRT
<213> Artificial Sequence

<220> 
<223> A synthetic sequence

<400> 7
Met Ala Cys Asn Cys Gln Leu Met Gln Asp Thr Pro Leu Leu Lys Phe
 1               5                  10                  15
Pro Cys Pro Arg Leu Ile Leu Leu Phe Val Leu Leu Ile Arg Leu Ser
            20                  25                  30
Gln Val Ser Ser Gly Val Ile His Val Thr Lys Glu Val Lys Glu Val
        35                  40                  45
Ala Thr Leu Ser Cys Gly His Asn Val Ser Val Glu Glu Leu Ala Gln
    50                  55                  60
Thr Arg Ile Tyr Trp Gln Lys Glu Lys Lys Met Val Leu Thr Met Met
65                  70                  75                  80
Ser Gly Asp Met Asn Ile Trp Pro Glu Tyr Lys Asn Arg Thr Ile Phe
                85                  90                  95
Asp Ile Thr Asn Asn Leu Ser Ile Val Ile Leu Ala Leu Arg Pro Ser
            100                 105                 110
Asp Glu Gly Thr Tyr Glu Cys Val Val Leu Lys Tyr Glu Lys Asp Ala
        115                 120                 125
Phe Lys Arg Glu His Leu Ala Glu Val Thr Leu Ser Val Lys Ala Asp
    130                 135                 140
Phe Ser Thr Pro Asn Ile Thr Glu Ser Gly Asn Pro Ser Ala Asp Thr
145                 150                 155                 160
Lys Arg Ile Thr Cys Phe Ala Ser Gly Gly Phe Pro Lys Pro Arg Phe
                165                 170                 175
Ser Trp Leu Glu Asn Gly Arg Glu Leu Pro Gly Ile Asn Thr Thr Ile
            180                 185                 190
Ser Gln Asp Pro Glu Ser Glu Leu Tyr Thr Ile Ser Ser Gln Leu Asp
        195                 200                 205
Phe Asn Thr Thr Arg Asn His Thr Ile Lys Cys Leu Ile Lys Tyr Gly
    210                 215                 220
Asp Ala His Val Ser Glu Asp Phe Thr Trp Glu Lys Pro Pro Glu Asp
225                 230                 235                 240
Pro Pro Asp Ser Lys Asn Thr Leu Val Leu Phe Gly Ala Gly Phe Gly
                245                 250                 255
Ala Val Ile Thr Val Val Val Ile Val Val Ile Ile Lys Cys Phe Cys
            260                 265                 270
Lys His Arg Ser Cys Phe Arg Arg Asn Glu Ala Ser Arg Glu Thr Asn
        275                 280                 285
Asn Ser Leu Thr Phe Gly Pro Glu Glu Ala Leu Ala Glu Gln Thr Val
    290                 295                 300
Phe Leu
305

<210> 8
<211> 427
<212> PRT
<213> Homo sapiens

<400> 8
Met Gly Ala Gly Ala Thr Gly Arg Ala Met Asp Gly Pro Arg Leu Leu
 1               5                  10                  15
Leu Leu Leu Leu Leu Gly Val Ser Leu Gly Gly Ala Lys Glu Ala Cys
            20                  25                  30
Pro Thr Gly Leu Tyr Thr His Ser Gly Glu Cys Cys Lys Ala Cys Asn
        35                  40                  45
Leu Gly Glu Gly Val Ala Gln Pro Cys Gly Ala Asn Gln Thr Val Cys
    50                  55                  60
Glu Pro Cys Leu Asp Ser Val Thr Phe Ser Asp Val Val Ser Ala Thr
65                  70                  75                  80
Glu Pro Cys Lys Pro Cys Thr Glu Cys Val Gly Leu Gln Ser Met Ser
                85                  90                  95
Ala Pro Cys Val Glu Ala Asp Asp Ala Val Cys Arg Cys Ala Tyr Gly
            100                 105                 110
Tyr Tyr Gln Asp Glu Thr Thr Gly Arg Cys Glu Ala Cys Arg Val Cys
        115                 120                 125
Glu Ala Gly Ser Gly Leu Val Phe Ser Cys Gln Asp Lys Gln Asn Thr
    130                 135                 140
Val Cys Glu Glu Cys Pro Asp Gly Thr Tyr Ser Asp Glu Ala Asn His
145                 150                 155                 160
Val Asp Pro Cys Leu Pro Cys Thr Val Cys Glu Asp Thr Glu Arg Gln
                165                 170                 175
Leu Arg Glu Cys Thr Arg Trp Ala Asp Ala Glu Cys Glu Glu Ile Pro
            180                 185                 190
Gly Arg Trp Ile Thr Arg Ser Thr Pro Pro Glu Gly Ser Asp Ser Thr
        195                 200                 205
Ala Pro Ser Thr Gln Glu Pro Glu Ala Pro Pro Glu Gln Asp Leu Ile
    210                 215                 220
Ala Ser Thr Val Ala Gly Val Val Thr Thr Val Met Gly Ser Ser Gln
225                 230                 235                 240
Pro Val Val Thr Arg Gly Thr Thr Asp Asn Leu Ile Pro Val Tyr Cys
                245                 250                 255
Ser Ile Leu Ala Ala Val Val Val Gly Leu Val Ala Tyr Ile Ala Phe
            260                 265                 270
Lys Arg Trp Asn Ser Cys Lys Gln Asn Lys Gln Gly Ala Asn Ser Arg
        275                 280                 285
Pro Val Asn Gln Thr Pro Pro Pro Glu Gly Glu Lys Leu His Ser Asp
    290                 295                 300
Ser Gly Ile Ser Val Asp Ser Gln Ser Leu His Asp Gln Gln Pro His
305                 310                 315                 320
Thr Gln Thr Ala Ser Gly Gln Ala Leu Lys Gly Asp Gly Gly Leu Tyr
                325                 330                 335
Ser Ser Leu Pro Pro Ala Lys Arg Glu Glu Val Glu Lys Leu Leu Asn
            340                 345                 350
Gly Ser Ala Gly Asp Thr Trp Arg His Leu Ala Gly Glu Leu Gly Tyr
        355                 360                 365
Gln Pro Glu His Ile Asp Ser Phe Thr His Glu Ala Cys Pro Val Arg
    370                 375                 380
Ala Leu Leu Ala Ser Trp Ala Thr Gln Asp Ser Ala Thr Leu Asp Ala
385                 390                 395                 400
Leu Leu Ala Ala Leu Arg Arg Ile Gln Arg Ala Asp Leu Val Glu Ser
                405                 410                 415
Leu Cys Ser Glu Ser Thr Ala Thr Ser Pro Val
            420                 425

<210> 9
<211> 20
<212> PRT
<213> Homo sapiens

<400> 9
Leu Ile Pro Val Tyr Cys Ser Ile Leu Ala Ala Val Val Val Gly Leu
 1               5                  10                  15
Val Ala Tyr Ile
            20

<210> 10
<211> 3408
<212> DNA
<213> Homo sapiens

<400> 10
agagcgagcc gagccgcggc cagctccggc gggcaggggg ggcgctggag cgcagcgcag      60
cgcagcccca tcagtccgca aagcggaccg agctggaagt cgagcgctgc cgcgggaggc     120
gggcgatggg ggcaggtgcc accggccgcg ccatggacgg gccgcgcctg ctgctgttgc     180
tgcttctggg ggtgtccctt ggaggtgcca aggaggcatg ccccacaggc ctgtacacac     240
acagcggtga gtgctgcaaa gcctgcaacc tgggcgaggg tgtggcccag ccttgtggag     300
ccaaccagac cgtgtgtgag ccctgcctgg acagcgtgac gttctccgac gtggtgagcg     360
cgaccgagcc gtgcaagccg tgcaccgagt gcgtggggct ccagagcatg tcggcgccgt     420
gcgtggaggc cgacgacgcc gtgtgccgct gcgcctacgg ctactaccag gatgagacga     480
ctgggcgctg cgaggcgtgc cgcgtgtgcg aggcgggctc gggcctcgtg ttctcctgcc     540
aggacaagca gaacaccgtg tgcgaggagt gccccgacgg cacgtattcc gacgaggcca     600
accacgtgga cccgtgcctg ccctgcaccg tgtgcgagga caccgagcgc cagctccgcg     660
agtgcacacg ctgggccgac gccgagtgcg aggagatccc tggccgttgg attacacggt     720
ccacaccccc agagggctcg gacagcacag cccccagcac ccaggagcct gaggcacctc     780
cagaacaaga cctcatagcc agcacggtgg caggtgtggt gaccacagtg atgggcagct     840
cccagcccgt ggtgacccga ggcaccaccg acaacctcat ccctgtctat tgctccatcc     900
tggctgctgt ggttgtgggc cttgtggcct acatagcctt caagaggtgg aacagctgca     960
agcagaacaa gcaaggagcc aacagccggc cagtgaacca gacgccccca ccagagggag    1020
aaaaactcca cagcgacagt ggcatctccg tggacagcca gagcctgcat gaccagcagc    1080
cccacacgca gacagcctcg ggccaggccc tcaagggtga cggaggcctc tacagcagcc    1140
tgcccccagc caagcgggag gaggtggaga agcttctcaa cggctctgcg ggggacacct    1200
ggcggcacct ggcgggcgag ctgggctacc agcccgagca catagactcc tttacccatg    1260
aggcctgccc cgttcgcgcc ctgcttgcaa gctgggccac ccaggacagc gccacactgg    1320
acgccctcct ggccgccctg cgccgcatcc agcgagccga cctcgtggag agtctgtgca    1380
gtgagtccac tgccacatcc ccggtgtgag cccaaccggg gagcccccgc cccgccccac    1440
attccgacaa ccgatgctcc agccaacccc tgtggagccc gcacccccac cctttggggg    1500
gggcccgcct ggcagaactg agctcctctg ggcaggacct cagagtccag gccccaaaac    1560
cacagccctg tcagtgcagc ccgtgtggcc ccttcacttc tgaccacact tcctgtccag    1620
agagagaagt gcccctgctg cctccccaac cctgcccctg ccccgtcacc atctcaggcc    1680
acctgccccc ttctcccaca ctgctaggtg ggccagcccc tcccaccaca gcaggtgtca    1740
tatatggggg gccaacacca gggatggtac tagggggaag tgacaaggcc ccagagactc    1800
agagggagga atcgaggaac cagagccatg gactctacac tgtgaacttg gggaacaagg    1860
gtggcatccc agtggcctca accctccctc agcccctctt gccccccacc ccagcctaag    1920
atgaagagga tcggaggctt gtcagagctg ggaggggttt tcgaagctca gcccaccccc    1980
ctcattttgg atataggtca gtgaggccca gggagaggcc atgattcgcc caaagccaga    2040
cagcaacggg gaggccaagt gcaggctggc accgccttct ctaaatgagg ggcctcaggt    2100
ttgcctgagg gcgaggggag ggtggcaggt gaccttctgg gaaatggctt gaagccaagt    2160
cagctttgcc ttccacgctg tctccagacc cccacccctt ccccactgcc tgcccacccg    2220
tggagatggg atgcttgcct agggcctggt ccatgatgga gtcaggtttg gggttcgtgg    2280
aaagggtgct gcttccctct gcctgtccct ctcaggcatg cctgtgtgac atcagtggca    2340
tggctccagt ctgctgccct ccatcccgac atggacccgg agctaacact ggcccctaga    2400
atcagcctag gggtcaggga ccaaggaccc ctcaccttgc aacacacaga cacacgcaca    2460
cacacacaca ggaggagaaa tctcactttt ctccatgagt tttttctctt gggctgagac    2520
tggatactgc ccggggcagc tgccagagaa gcatcggagg gaattgaggt ctgctcggcc    2580
gtcttcactc gcccccgggt ttggcgggcc aaggactgcc gaccgaggct ggagctggcg    2640
tctgtcttca agggcttaca cgtggaggaa tgctccccca tcctcccctt ccctgcaaac    2700
atggggttgg ctgggcccag aaggttgtga tgaagaaaag tgggccagtg tgggaatgcg    2760
gcaagaagga attgacttcg actgtgacct gtggggattt ctcccagctc tagacaaccc    2820
tgcaaaggac tgttttttcc tgagcttggc cagaaggggg ccatgaggcc tcagtggact    2880
ttccaccccc tccctggcct gttctgtttt gcctgaagtt ggagtgagtg tggctcccct    2940
ctatttagca tgacaagccc caggcaggct gtgcgctgac aaccaccgct ccccagccca    3000
gggttccccc agccctgtgg aagggactag gagcactgta gtaaatggca attctttgac    3060
ctcaacctgt gatgagggga ggaaactcac ctgctggccc ctcacctggg cacctgggga    3120
gtgggacaga gtctgggtgt atttattttc ctccccagca ggtggggagg gggtttgggg    3180
gcttgcaagt atgttttagc atgtgtttgg ttctggggcc cctttttact ccccttgagc    3240
tgagatggaa cccttttggc ccccgagctg ggggccatga gctccagacc cccagcaacc    3300
ctcctatcac ctcccctcct tgcctcctgt gtaatcattt cttgggccct cctgaaactt    3360
acacacaaaa cgttaagtga tgaacattaa atagcaaaga aagaaaaa                 3408

<210> 11
<211> 8
<212> PRT
<213> Homo sapiens

<400> 11
Leu Ser Arg Lys Ile Gly Arg Thr
 1               5

<210> 12
<211> 9
<212> PRT
<213> Homo sapiens

<400> 12
Leu Ser Arg Lys Ala Val Arg Arg Ala
 1               5
