                         SEQUENCE LISTING

<110>  Alexion Pharmaceuticals, Inc.
 
<120>  Compositions and Methods for Inhibiting Complement Component 3 
       Expression

<130>  50694-093WO3

<150>  US 63/177,254
<151>  2021-04-20

<160>  67    

<170>  PatentIn version 3.5

<210>  1
<211>  36
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Synthetic Construct

<400>  1
aucaacucac cuguaauaaa gcagccgaaa ggcugc                                 36


<210>  2
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Synthetic Construct

<400>  2
aucaacucac cuguaauaaa                                                   20


<210>  3
<211>  22
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Synthetic Construct

<400>  3
uuuauuacag gugaguugau gg                                                22


<210>  4
<211>  36
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Synthetic Construct

<400>  4
agaaauucua cuacaucuaa gcagccgaaa ggcugc                                 36


<210>  5
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Synthetic Construct

<400>  5
agaaauucua cuacaucuaa                                                   20


<210>  6
<211>  22
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Synthetic Construct

<400>  6
uuagauguag uagaauuucu gg                                                22


<210>  7
<211>  16
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Synthetic Construct

<400>  7
gcagccgaaa ggcugc                                                       16


<210>  8
<211>  4
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Synthetic Construct

<400>  8
gaaa                                                                     4


<210>  9
<211>  58
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Synthetic Construct

<400>  9
aucaacucac cuguaauaaa gcagccgaaa ggcugcuuua uuacagguga guugaugg         58


<210>  10
<211>  58
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Synthetic Construct

<400>  10
agaaauucua cuacaucuaa gcagccgaaa ggcugcuuag auguaguaga auuucugg        58


<210>  11
<211>  1663
<212>  PRT
<213>  Homo sapiens

<400>  11

Met Gly Pro Thr Ser Gly Pro Ser Leu Leu Leu Leu Leu Leu Thr His 
1               5                   10                  15      


Leu Pro Leu Ala Leu Gly Ser Pro Met Tyr Ser Ile Ile Thr Pro Asn 
            20                  25                  30          


Ile Leu Arg Leu Glu Ser Glu Glu Thr Met Val Leu Glu Ala His Asp 
        35                  40                  45              


Ala Gln Gly Asp Val Pro Val Thr Val Thr Val His Asp Phe Pro Gly 
    50                  55                  60                  


Lys Lys Leu Val Leu Ser Ser Glu Lys Thr Val Leu Thr Pro Ala Thr 
65                  70                  75                  80  


Asn His Met Gly Asn Val Thr Phe Thr Ile Pro Ala Asn Arg Glu Phe 
                85                  90                  95      


Lys Ser Glu Lys Gly Arg Asn Lys Phe Val Thr Val Gln Ala Thr Phe 
            100                 105                 110         


Gly Thr Gln Val Val Glu Lys Val Val Leu Val Ser Leu Gln Ser Gly 
        115                 120                 125             


Tyr Leu Phe Ile Gln Thr Asp Lys Thr Ile Tyr Thr Pro Gly Ser Thr 
    130                 135                 140                 


Val Leu Tyr Arg Ile Phe Thr Val Asn His Lys Leu Leu Pro Val Gly 
145                 150                 155                 160 


Arg Thr Val Met Val Asn Ile Glu Asn Pro Glu Gly Ile Pro Val Lys 
                165                 170                 175     


Gln Asp Ser Leu Ser Ser Gln Asn Gln Leu Gly Val Leu Pro Leu Ser 
            180                 185                 190         


Trp Asp Ile Pro Glu Leu Val Asn Met Gly Gln Trp Lys Ile Arg Ala 
        195                 200                 205             


Tyr Tyr Glu Asn Ser Pro Gln Gln Val Phe Ser Thr Glu Phe Glu Val 
    210                 215                 220                 


Lys Glu Tyr Val Leu Pro Ser Phe Glu Val Ile Val Glu Pro Thr Glu 
225                 230                 235                 240 


Lys Phe Tyr Tyr Ile Tyr Asn Glu Lys Gly Leu Glu Val Thr Ile Thr 
                245                 250                 255     


Ala Arg Phe Leu Tyr Gly Lys Lys Val Glu Gly Thr Ala Phe Val Ile 
            260                 265                 270         


Phe Gly Ile Gln Asp Gly Glu Gln Arg Ile Ser Leu Pro Glu Ser Leu 
        275                 280                 285             


Lys Arg Ile Pro Ile Glu Asp Gly Ser Gly Glu Val Val Leu Ser Arg 
    290                 295                 300                 


Lys Val Leu Leu Asp Gly Val Gln Asn Pro Arg Ala Glu Asp Leu Val 
305                 310                 315                 320 


Gly Lys Ser Leu Tyr Val Ser Ala Thr Val Ile Leu His Ser Gly Ser 
                325                 330                 335     


Asp Met Val Gln Ala Glu Arg Ser Gly Ile Pro Ile Val Thr Ser Pro 
            340                 345                 350         


Tyr Gln Ile His Phe Thr Lys Thr Pro Lys Tyr Phe Lys Pro Gly Met 
        355                 360                 365             


Pro Phe Asp Leu Met Val Phe Val Thr Asn Pro Asp Gly Ser Pro Ala 
    370                 375                 380                 


Tyr Arg Val Pro Val Ala Val Gln Gly Glu Asp Thr Val Gln Ser Leu 
385                 390                 395                 400 


Thr Gln Gly Asp Gly Val Ala Lys Leu Ser Ile Asn Thr His Pro Ser 
                405                 410                 415     


Gln Lys Pro Leu Ser Ile Thr Val Arg Thr Lys Lys Gln Glu Leu Ser 
            420                 425                 430         


Glu Ala Glu Gln Ala Thr Arg Thr Met Gln Ala Leu Pro Tyr Ser Thr 
        435                 440                 445             


Val Gly Asn Ser Asn Asn Tyr Leu His Leu Ser Val Leu Arg Thr Glu 
    450                 455                 460                 


Leu Arg Pro Gly Glu Thr Leu Asn Val Asn Phe Leu Leu Arg Met Asp 
465                 470                 475                 480 


Arg Ala His Glu Ala Lys Ile Arg Tyr Tyr Thr Tyr Leu Ile Met Asn 
                485                 490                 495     


Lys Gly Arg Leu Leu Lys Ala Gly Arg Gln Val Arg Glu Pro Gly Gln 
            500                 505                 510         


Asp Leu Val Val Leu Pro Leu Ser Ile Thr Thr Asp Phe Ile Pro Ser 
        515                 520                 525             


Phe Arg Leu Val Ala Tyr Tyr Thr Leu Ile Gly Ala Ser Gly Gln Arg 
    530                 535                 540                 


Glu Val Val Ala Asp Ser Val Trp Val Asp Val Lys Asp Ser Cys Val 
545                 550                 555                 560 


Gly Ser Leu Val Val Lys Ser Gly Gln Ser Glu Asp Arg Gln Pro Val 
                565                 570                 575     


Pro Gly Gln Gln Met Thr Leu Lys Ile Glu Gly Asp His Gly Ala Arg 
            580                 585                 590         


Val Val Leu Val Ala Val Asp Lys Gly Val Phe Val Leu Asn Lys Lys 
        595                 600                 605             


Asn Lys Leu Thr Gln Ser Lys Ile Trp Asp Val Val Glu Lys Ala Asp 
    610                 615                 620                 


Ile Gly Cys Thr Pro Gly Ser Gly Lys Asp Tyr Ala Gly Val Phe Ser 
625                 630                 635                 640 


Asp Ala Gly Leu Thr Phe Thr Ser Ser Ser Gly Gln Gln Thr Ala Gln 
                645                 650                 655     


Arg Ala Glu Leu Gln Cys Pro Gln Pro Ala Ala Arg Arg Arg Arg Ser 
            660                 665                 670         


Val Gln Leu Thr Glu Lys Arg Met Asp Lys Val Gly Lys Tyr Pro Lys 
        675                 680                 685             


Glu Leu Arg Lys Cys Cys Glu Asp Gly Met Arg Glu Asn Pro Met Arg 
    690                 695                 700                 


Phe Ser Cys Gln Arg Arg Thr Arg Phe Ile Ser Leu Gly Glu Ala Cys 
705                 710                 715                 720 


Lys Lys Val Phe Leu Asp Cys Cys Asn Tyr Ile Thr Glu Leu Arg Arg 
                725                 730                 735     


Gln His Ala Arg Ala Ser His Leu Gly Leu Ala Arg Ser Asn Leu Asp 
            740                 745                 750         


Glu Asp Ile Ile Ala Glu Glu Asn Ile Val Ser Arg Ser Glu Phe Pro 
        755                 760                 765             


Glu Ser Trp Leu Trp Asn Val Glu Asp Leu Lys Glu Pro Pro Lys Asn 
    770                 775                 780                 


Gly Ile Ser Thr Lys Leu Met Asn Ile Phe Leu Lys Asp Ser Ile Thr 
785                 790                 795                 800 


Thr Trp Glu Ile Leu Ala Val Ser Met Ser Asp Lys Lys Gly Ile Cys 
                805                 810                 815     


Val Ala Asp Pro Phe Glu Val Thr Val Met Gln Asp Phe Phe Ile Asp 
            820                 825                 830         


Leu Arg Leu Pro Tyr Ser Val Val Arg Asn Glu Gln Val Glu Ile Arg 
        835                 840                 845             


Ala Val Leu Tyr Asn Tyr Arg Gln Asn Gln Glu Leu Lys Val Arg Val 
    850                 855                 860                 


Glu Leu Leu His Asn Pro Ala Phe Cys Ser Leu Ala Thr Thr Lys Arg 
865                 870                 875                 880 


Arg His Gln Gln Thr Val Thr Ile Pro Pro Lys Ser Ser Leu Ser Val 
                885                 890                 895     


Pro Tyr Val Ile Val Pro Leu Lys Thr Gly Leu Gln Glu Val Glu Val 
            900                 905                 910         


Lys Ala Ala Val Tyr His His Phe Ile Ser Asp Gly Val Arg Lys Ser 
        915                 920                 925             


Leu Lys Val Val Pro Glu Gly Ile Arg Met Asn Lys Thr Val Ala Val 
    930                 935                 940                 


Arg Thr Leu Asp Pro Glu Arg Leu Gly Arg Glu Gly Val Gln Lys Glu 
945                 950                 955                 960 


Asp Ile Pro Pro Ala Asp Leu Ser Asp Gln Val Pro Asp Thr Glu Ser 
                965                 970                 975     


Glu Thr Arg Ile Leu Leu Gln Gly Thr Pro Val Ala Gln Met Thr Glu 
            980                 985                 990         


Asp Ala Val Asp Ala Glu Arg Leu  Lys His Leu Ile Val  Thr Pro Ser 
        995                 1000                 1005             


Gly Cys  Gly Glu Gln Asn Met  Ile Gly Met Thr Pro  Thr Val Ile 
    1010                 1015                 1020             


Ala Val  His Tyr Leu Asp Glu  Thr Glu Gln Trp Glu  Lys Phe Gly 
    1025                 1030                 1035             


Leu Glu  Lys Arg Gln Gly Ala  Leu Glu Leu Ile Lys  Lys Gly Tyr 
    1040                 1045                 1050             


Thr Gln  Gln Leu Ala Phe Arg  Gln Pro Ser Ser Ala  Phe Ala Ala 
    1055                 1060                 1065             


Phe Val  Lys Arg Ala Pro Ser  Thr Trp Leu Thr Ala  Tyr Val Val 
    1070                 1075                 1080             


Lys Val  Phe Ser Leu Ala Val  Asn Leu Ile Ala Ile  Asp Ser Gln 
    1085                 1090                 1095             


Val Leu  Cys Gly Ala Val Lys  Trp Leu Ile Leu Glu  Lys Gln Lys 
    1100                 1105                 1110             


Pro Asp  Gly Val Phe Gln Glu  Asp Ala Pro Val Ile  His Gln Glu 
    1115                 1120                 1125             


Met Ile  Gly Gly Leu Arg Asn  Asn Asn Glu Lys Asp  Met Ala Leu 
    1130                 1135                 1140             


Thr Ala  Phe Val Leu Ile Ser  Leu Gln Glu Ala Lys  Asp Ile Cys 
    1145                 1150                 1155             


Glu Glu  Gln Val Asn Ser Leu  Pro Gly Ser Ile Thr  Lys Ala Gly 
    1160                 1165                 1170             


Asp Phe  Leu Glu Ala Asn Tyr  Met Asn Leu Gln Arg  Ser Tyr Thr 
    1175                 1180                 1185             


Val Ala  Ile Ala Gly Tyr Ala  Leu Ala Gln Met Gly  Arg Leu Lys 
    1190                 1195                 1200             


Gly Pro  Leu Leu Asn Lys Phe  Leu Thr Thr Ala Lys  Asp Lys Asn 
    1205                 1210                 1215             


Arg Trp  Glu Asp Pro Gly Lys  Gln Leu Tyr Asn Val  Glu Ala Thr 
    1220                 1225                 1230             


Ser Tyr  Ala Leu Leu Ala Leu  Leu Gln Leu Lys Asp  Phe Asp Phe 
    1235                 1240                 1245             


Val Pro  Pro Val Val Arg Trp  Leu Asn Glu Gln Arg  Tyr Tyr Gly 
    1250                 1255                 1260             


Gly Gly  Tyr Gly Ser Thr Gln  Ala Thr Phe Met Val  Phe Gln Ala 
    1265                 1270                 1275             


Leu Ala  Gln Tyr Gln Lys Asp  Ala Pro Asp His Gln  Glu Leu Asn 
    1280                 1285                 1290             


Leu Asp  Val Ser Leu Gln Leu  Pro Ser Arg Ser Ser  Lys Ile Thr 
    1295                 1300                 1305             


His Arg  Ile His Trp Glu Ser  Ala Ser Leu Leu Arg  Ser Glu Glu 
    1310                 1315                 1320             


Thr Lys  Glu Asn Glu Gly Phe  Thr Val Thr Ala Glu  Gly Lys Gly 
    1325                 1330                 1335             


Gln Gly  Thr Leu Ser Val Val  Thr Met Tyr His Ala  Lys Ala Lys 
    1340                 1345                 1350             


Asp Gln  Leu Thr Cys Asn Lys  Phe Asp Leu Lys Val  Thr Ile Lys 
    1355                 1360                 1365             


Pro Ala  Pro Glu Thr Glu Lys  Arg Pro Gln Asp Ala  Lys Asn Thr 
    1370                 1375                 1380             


Met Ile  Leu Glu Ile Cys Thr  Arg Tyr Arg Gly Asp  Gln Asp Ala 
    1385                 1390                 1395             


Thr Met  Ser Ile Leu Asp Ile  Ser Met Met Thr Gly  Phe Ala Pro 
    1400                 1405                 1410             


Asp Thr  Asp Asp Leu Lys Gln  Leu Ala Asn Gly Val  Asp Arg Tyr 
    1415                 1420                 1425             


Ile Ser  Lys Tyr Glu Leu Asp  Lys Ala Phe Ser Asp  Arg Asn Thr 
    1430                 1435                 1440             


Leu Ile  Ile Tyr Leu Asp Lys  Val Ser His Ser Glu  Asp Asp Cys 
    1445                 1450                 1455             


Leu Ala  Phe Lys Val His Gln  Tyr Phe Asn Val Glu  Leu Ile Gln 
    1460                 1465                 1470             


Pro Gly  Ala Val Lys Val Tyr  Ala Tyr Tyr Asn Leu  Glu Glu Ser 
    1475                 1480                 1485             


Cys Thr  Arg Phe Tyr His Pro  Glu Lys Glu Asp Gly  Lys Leu Asn 
    1490                 1495                 1500             


Lys Leu  Cys Arg Asp Glu Leu  Cys Arg Cys Ala Glu  Glu Asn Cys 
    1505                 1510                 1515             


Phe Ile  Gln Lys Ser Asp Asp  Lys Val Thr Leu Glu  Glu Arg Leu 
    1520                 1525                 1530             


Asp Lys  Ala Cys Glu Pro Gly  Val Asp Tyr Val Tyr  Lys Thr Arg 
    1535                 1540                 1545             


Leu Val  Lys Val Gln Leu Ser  Asn Asp Phe Asp Glu  Tyr Ile Met 
    1550                 1555                 1560             


Ala Ile  Glu Gln Thr Ile Lys  Ser Gly Ser Asp Glu  Val Gln Val 
    1565                 1570                 1575             


Gly Gln  Gln Arg Thr Phe Ile  Ser Pro Ile Lys Cys  Arg Glu Ala 
    1580                 1585                 1590             


Leu Lys  Leu Glu Glu Lys Lys  His Tyr Leu Met Trp  Gly Leu Ser 
    1595                 1600                 1605             


Ser Asp  Phe Trp Gly Glu Lys  Pro Asn Leu Ser Tyr  Ile Ile Gly 
    1610                 1615                 1620             


Lys Asp  Thr Trp Val Glu His  Trp Pro Glu Glu Asp  Glu Cys Gln 
    1625                 1630                 1635             


Asp Glu  Glu Asn Gln Lys Gln  Cys Gln Asp Leu Gly  Ala Phe Thr 
    1640                 1645                 1650             


Glu Ser  Met Val Val Phe Gly  Cys Pro Asn 
    1655                 1660             


<210>  12
<211>  5231
<212>  DNA
<213>  Homo sapiens

<400>  12
actcctcccc atcctctccc tctgtccctc tgtccctctg accctgcact gtcccagcac       60

catgggaccc acctcaggtc ccagcctgct gctcctgcta ctaacccacc tccccctggc      120

tctggggagt cccatgtact ctatcatcac ccccaacatc ttgcggctgg agagcgagga      180

gaccatggtg ctggaggccc acgacgcgca aggggatgtt ccagtcactg ttactgtcca      240

cgacttccca ggcaaaaaac tagtgctgtc cagtgagaag actgtgctga cccctgccac      300

caaccacatg ggcaacgtca ccttcacgat cccagccaac agggagttca agtcagaaaa      360

ggggcgcaac aagttcgtga ccgtgcaggc caccttcggg acccaagtgg tggagaaggt      420

ggtgctggtc agcctgcaga gcgggtacct cttcatccag acagacaaga ccatctacac      480

ccctggctcc acagttctct atcggatctt caccgtcaac cacaagctgc tacccgtggg      540

ccggacggtc atggtcaaca ttgagaaccc ggaaggcatc ccggtcaagc aggactcctt      600

gtcttctcag aaccagcttg gcgtcttgcc cttgtcttgg gacattccgg aactcgtcaa      660

catgggccag tggaagatcc gagcctacta tgaaaactca ccacagcagg tcttctccac      720

tgagtttgag gtgaaggagt acgtgctgcc cagtttcgag gtcatagtgg agcctacaga      780

gaaattctac tacatctata acgagaaggg cctggaggtc accatcaccg ccaggttcct      840

ctacgggaag aaagtggagg gaactgcctt tgtcatcttc gggatccagg atggcgaaca      900

gaggatttcc ctgcctgaat ccctcaagcg cattccgatt gaggatggct cgggggaggt      960

tgtgctgagc cggaaggtac tgctggacgg ggtgcagaac ccccgagcag aagacctggt     1020

ggggaagtct ttgtacgtgt ctgccaccgt catcttgcac tcaggcagtg acatggtgca     1080

ggcagagcgc agcgggatcc ccatcgtgac ctctccctac cagatccact tcaccaagac     1140

acccaagtac ttcaaaccag gaatgccctt tgacctcatg gtgttcgtga cgaaccctga     1200

tggctctcca gcctaccgag tccccgtggc agtccagggc gaggacactg tgcagtctct     1260

aacccaggga gatggcgtgg ccaaactcag catcaacaca caccccagcc agaagccctt     1320

gagcatcacg gtgcgcacga agaagcagga gctctcggag gcagagcagg ctaccaggac     1380

catgcaggct ctgccctaca gcaccgtggg caactccaac aattacctgc atctctcagt     1440

gctacgtaca gagctcagac ccggggagac cctcaacgtc aacttcctcc tgcgaatgga     1500

ccgcgcccac gaggccaaga tccgctacta cacctacctg atcatgaaca agggcaggct     1560

gttgaaggcg ggacgccagg tgcgagagcc cggccaggac ctggtggtgc tgcccctgtc     1620

catcaccacc gacttcatcc cttccttccg cctggtggcg tactacacgc tgatcggtgc     1680

cagcggccag agggaggtgg tggccgactc cgtgtgggtg gacgtcaagg actcctgcgt     1740

gggctcgctg gtggtaaaaa gcggccagtc agaagaccgg cagcctgtac ctgggcagca     1800

gatgaccctg aagatagagg gtgaccacgg ggcccgggtg gtactggtgg ccgtggacaa     1860

gggcgtgttc gtgctgaata agaagaacaa actgacgcag agtaagatct gggacgtggt     1920

ggagaaggca gacatcggct gcaccccggg cagtgggaag gattacgccg gtgtcttctc     1980

cgacgcaggg ctgaccttca cgagcagcag tggccagcag accgcccaga gggcagaact     2040

tcagtgcccg cagccagccg cccgccgacg ccgttccgtg cagctcacgg agaagcgaat     2100

ggacaaagtc ggcaagtacc ccaaggagct gcgcaagtgc tgcgaggacg gcatgcggga     2160

gaaccccatg aggttctcgt gccagcgccg gacccgtttc atctccctgg gcgaggcgtg     2220

caagaaggtc ttcctggact gctgcaacta catcacagag ctgcggcggc agcacgcgcg     2280

ggccagccac ctgggcctgg ccaggagtaa cctggatgag gacatcattg cagaagagaa     2340

catcgtttcc cgaagtgagt tcccagagag ctggctgtgg aacgttgagg acttgaaaga     2400

gccaccgaaa aatggaatct ctacgaagct catgaatata tttttgaaag actccatcac     2460

cacgtgggag attctggctg tgagcatgtc ggacaagaaa gggatctgtg tggcagaccc     2520

cttcgaggtc acagtaatgc aggacttctt catcgacctg cggctaccct actctgttgt     2580

tcgaaacgag caggtggaaa tccgagccgt tctctacaat taccggcaga accaagagct     2640

caaggtgagg gtggaactac tccacaatcc agccttctgc agcctggcca ccaccaagag     2700

gcgtcaccag cagaccgtaa ccatcccccc caagtcctcg ttgtccgttc catatgtcat     2760

cgtgccgcta aagaccggcc tgcaggaagt ggaagtcaag gctgctgtct accatcattt     2820

catcagtgac ggtgtcagga agtccctgaa ggtcgtgccg gaaggaatca gaatgaacaa     2880

aactgtggct gttcgcaccc tggatccaga acgcctgggc cgtgaaggag tgcagaaaga     2940

ggacatccca cctgcagacc tcagtgacca agtcccggac accgagtctg agaccagaat     3000

tctcctgcaa gggaccccag tggcccagat gacagaggat gccgtcgacg cggaacggct     3060

gaagcacctc attgtgaccc cctcgggctg cggggaacag aacatgatcg gcatgacgcc     3120

cacggtcatc gctgtgcatt acctggatga aacggagcag tgggagaagt tcggcctaga     3180

gaagcggcag ggggccttgg agctcatcaa gaaggggtac acccagcagc tggccttcag     3240

acaacccagc tctgcctttg cggccttcgt gaaacgggca cccagcacct ggctgaccgc     3300

ctacgtggtc aaggtcttct ctctggctgt caacctcatc gccatcgact cccaagtcct     3360

ctgcggggct gttaaatggc tgatcctgga gaagcagaag cccgacgggg tcttccagga     3420

ggatgcgccc gtgatacacc aagaaatgat tggtggatta cggaacaaca acgagaaaga     3480

catggccctc acggcctttg ttctcatctc gctgcaggag gctaaagata tttgcgagga     3540

gcaggtcaac agcctgccag gcagcatcac taaagcagga gacttccttg aagccaacta     3600

catgaaccta cagagatcct acactgtggc cattgctggc tatgctctgg cccagatggg     3660

caggctgaag gggcctcttc ttaacaaatt tctgaccaca gccaaagata agaaccgctg     3720

ggaggaccct ggtaagcagc tctacaacgt ggaggccaca tcctatgccc tcttggccct     3780

actgcagcta aaagactttg actttgtgcc tcccgtcgtg cgttggctca atgaacagag     3840

atactacggt ggtggctatg gctctaccca ggccaccttc atggtgttcc aagccttggc     3900

tcaataccaa aaggacgccc ctgaccacca ggaactgaac cttgatgtgt ccctccaact     3960

gcccagccgc agctccaaga tcacccaccg tatccactgg gaatctgcca gcctcctgcg     4020

atcagaagag accaaggaaa atgagggttt cacagtcaca gctgaaggaa aaggccaagg     4080

caccttgtcg gtggtgacaa tgtaccatgc taaggccaaa gatcaactca cctgtaataa     4140

attcgacctc aaggtcacca taaaaccagc accggaaaca gaaaagaggc ctcaggatgc     4200

caagaacact atgatccttg agatctgtac caggtaccgg ggagaccagg atgccactat     4260

gtctatattg gacatatcca tgatgactgg ctttgctcca gacacagatg acctgaagca     4320

gctggccaat ggtgttgaca gatacatctc caagtatgag ctggacaaag ccttctccga     4380

taggaacacc ctcatcatct acctggacaa ggtctcacac tctgaggatg actgtctagc     4440

tttcaaagtt caccaatact ttaatgtaga gcttatccag cctggagcag tcaaggtcta     4500

cgcctattac aacctggagg aaagctgtac ccggttctac catccggaaa aggaggatgg     4560

aaagctgaac aagctctgcc gtgatgaact gtgccgctgt gctgaggaga attgcttcat     4620

acaaaagtcg gatgacaagg tcaccctgga agaacggctg gacaaggcct gtgagccagg     4680

agtggactat gtgtacaaga cccgactggt caaggttcag ctgtccaatg actttgacga     4740

gtacatcatg gccattgagc agaccatcaa gtcaggctcg gatgaggtgc aggttggaca     4800

gcagcgcacg ttcatcagcc ccatcaagtg cagagaagcc ctgaagctgg aggagaagaa     4860

acactacctc atgtggggtc tctcctccga tttctgggga gagaagccca acctcagcta     4920

catcatcggg aaggacactt gggtggagca ctggcccgag gaggacgaat gccaagacga     4980

agagaaccag aaacaatgcc aggacctcgg cgccttcacc gagagcatgg ttgtctttgg     5040

gtgccccaac tgaccacacc cccattcccc cactccagat aaagcttcag ttatatctca     5100

cgtgtctgga gttctttgcc aagagggaga ggctgaaatc cccagccgcc tcacctgcag     5160

ctcagctcca tcctacttga aacctcacct gttcccaccg cattttctcc tggcgttcgc     5220

ctgctagtgt g                                                          5231


<210>  13
<211>  20
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Synthetic Construct

<400>  13
atcaactcac ctgtaataaa                                                   20


<210>  14
<211>  19
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Synthetic Construct

<400>  14
agaaattcta ctacatcta                                                    19


<210>  15
<211>  37
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Synthetic Construct

<400>  15
aggaaugaga aucaacaaaa agcagccgaa aggcugc                                37


<210>  16
<211>  21
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Synthetic Construct

<400>  16
uuuuguugau ucucauuccu g                                                 21


<210>  17
<211>  36
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Synthetic Construct

<400>  17
cagcuaaaag acuuugacua gcagccgaaa ggcugc                                 36


<210>  18
<211>  22
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Synthetic Construct

<400>  18
uagucaaagu cuuuuagcug gg                                                22


<210>  19
<211>  36
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Synthetic Construct

<400>  19
gcuaaaagac uuugacuuua gcagccgaaa ggcugc                                 36


<210>  20
<211>  22
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Synthetic Construct

<400>  20
uaaagucaaa gucuuuuagc gg                                                22


<210>  21
<211>  36
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Synthetic Construct

<400>  21
cucaaugaac agagauacua gcagccgaaa ggcugc                                 36


<210>  22
<211>  22
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Synthetic Construct

<400>  22
uaguaucucu guucauugag gg                                                22


<210>  23
<211>  36
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Synthetic Construct

<400>  23
ucaacucacc uguaauaaaa gcagccgaaa ggcugc                                 36


<210>  24
<211>  22
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Synthetic Construct

<400>  24
uuuuauuaca ggugaguuga gg                                                22


<210>  25
<211>  36
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Synthetic Construct

<400>  25
ugaggagaau ugcuucauaa gcagccgaaa ggcugc                                 36


<210>  26
<211>  22
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Synthetic Construct

<400>  26
uuaugaagca auucuccuca gg                                                22


<210>  27
<211>  36
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Synthetic Construct

<400>  27
ggagaauugc uucauacaaa gcagccgaaa ggcugc                                 36


<210>  28
<211>  22
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Synthetic Construct

<400>  28
uuuguaugaa gcaauucucc gg                                                22


<210>  29
<211>  36
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Synthetic Construct

<400>  29
agauaaagcu ucaguuauaa gcagccgaaa ggcugc                                 36


<210>  30
<211>  22
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Synthetic Construct

<400>  30
uuauaacuga agcuuuaucu gg                                                22


<210>  31
<211>  20
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Synthetic Construct

<400>  31
aggaatgaga atcaacaaaa                                                   20


<210>  32
<211>  5139
<212>  DNA
<213>  Mus musculus

<400>  32
agagaggaga gccatataaa gagccagcgg ctacagcccc agctcgcctc tgcccacccc       60

tgccccttac cccttcattc cttccacctt tttccttcac tatgggacca gcttcagggt      120

cccagctact agtgctactg ctgctgttgg ccagctcccc attagctctg gggatcccca      180

tgtattccat cattactccc aatgtcctac ggctggagag cgaagagacc atcgtactgg      240

aggcccacga tgctcagggt gacatcccag tcacagtcac tgtgcaagac ttcctaaaga      300

ggcaagtgct gaccagtgag aagacagtgt tgacaggagc cagtggacat ctgagaagcg      360

tctccatcaa gattccagcc agtaaggaat tcaactcaga taaggagggg cacaagtacg      420

tgacagtggt ggcaaacttc ggggaaacgg tggtggagaa agcagtgatg gtaagcttcc      480

agagtgggta cctcttcatc cagacagaca agaccatcta cacccctggc tccactgtct      540

tatatcggat cttcactgtg gacaacaacc tactgcccgt gggcaagaca gtcgtcatcc      600

tcattgagac ccccgatggc attcctgtca agagagacat tctgtcttcc aacaaccaac      660

acggcatctt gcctttgtct tggaacattc ctgaactggt caacatgggg cagtggaaga      720

tccgagcctt ttacgaacat gcgccgaagc agatcttctc cgcagagttt gaggtgaagg      780

aatacgtgct gcccagtttt gaggtccggg tggagcccac agagacattt tattacatcg      840

atgacccaaa tggcctggaa gtttccatca tagccaagtt cctgtacggg aaaaacgtgg      900

acgggacagc cttcgtgatt tttggggtcc aggatggcga taagaagatt tctctggccc      960

actccctcac gcgcgtagtg attgaggatg gtgtggggga tgcagtgctg acccggaagg     1020

tgctgatgga gggggtacgg ccttccaacg ccgacgccct ggtggggaag tccctgtatg     1080

tctccgtcac tgtcatcctg cactcaggta gtgacatggt agaggcagag cgcagtggga     1140

tcccgattgt cacttccccg taccagatcc acttcaccaa gacacccaaa ttcttcaagc     1200

cagccatgcc ctttgacctc atggtgttcg tgaccaaccc cgatggctct ccggccagca     1260

aagtgctggt ggtcactcag ggatctaatg caaaggctct cacccaagat gatggcgtgg     1320

ccaagctaag catcaacaca cccaacagcc gccaacccct gaccatcaca gtccgcacca     1380

agaaggacac tctcccagaa tcacggcagg ccaccaagac aatggaggcc catccctaca     1440

gcactatgca caactccaac aactacctac acttgtcagt gtcacgaatg gagctcaagc     1500

cgggggacaa cctcaatgtc aacttccacc tgcgcacaga cccaggccat gaggccaaga     1560

tccgatacta cacctacctg gttatgaaca aggggaagct cctgaaggca ggccgccagg     1620

ttcgggagcc tggccaggac ctggtggtct tgtccctgcc catcactcca gagtttattc     1680

cttcatttcg cctggtggct tactacaccc tgattggagc tagtggccag agggaggtgg     1740

tggctgactc tgtgtgggtg gatgtgaagg attcctgtat tggcacgctg gtggtgaagg     1800

gtgacccaag agataaccat ctcgcacctg ggcaacaaac gacactcagg attgaaggaa     1860

accagggggc ccgagtgggg ctagtggctg tggacaaggg agtgtttgtg ctgaacaaga     1920

agaacaaact cacacagagc aagatctggg atgtggtaga gaaggcagac attggctgca     1980

ccccaggcag tgggaagaac tatgctggtg tcttcatgga tgcaggcctg gccttcaaga     2040

caagccaagg actgcagact gaacagagag cagatcttga gtgcaccaag ccagcagccc     2100

gccgccgtcg ctcagtacag ttgatggaaa gaaggatgga caaagctggt cagtacactg     2160

acaagggtct tcggaagtgt tgtgaggatg gtatgcggga tatccctatg agatacagct     2220

gccagcgccg ggcacgcctc atcacccagg gcgagaactg cataaaggcc ttcatagact     2280

gctgcaacca catcaccaag ctgcgtgaac aacacagaag agaccacgtg ctgggcctgg     2340

ccaggagtga attggaggaa gacataattc cagaagaaga tattatctct agaagccact     2400

tcccacagag ctggttgtgg accatagaag agttgaaaga accagagaaa aatggaatct     2460

ctacgaaggt catgaacatc tttctcaaag attccatcac cacctgggag attctggcag     2520

tgagcttgtc agacaagaaa gggatctgtg tggcagaccc ctatgagatc agagtgatgc     2580

aggacttctt cattgacctg cggctgccct actctgtagt gcgcaacgaa caggtggaga     2640

tcagagctgt gctcttcaac taccgtgaac aggaggaact taaggtgagg gtggaactgt     2700

tgcataatcc agccttctgc agcatggcca ccgccaagaa tcgctacttc cagaccatca     2760

aaatccctcc caagtcctcg gtggctgtac cgtatgtcat tgtccccttg aagatcggcc     2820

aacaagaggt ggaggtcaag gctgctgtct tcaatcactt catcagtgat ggtgtcaaga     2880

agacactgaa ggtcgtgcca gaaggaatga gaatcaacaa aactgtggcc atccatacac     2940

tggacccaga gaagctcggt caagggggag tgcagaaggt ggatgtgcct gccgcagacc     3000

ttagcgacca agtgccagac acagactctg agaccagaat tatcctgcaa gggagcccgg     3060

tggttcagat ggctgaagat gctgtggacg gggagcggct gaaacacctg atcgtgaccc     3120

ccgcaggctg tggggaacag aacatgattg gcatgacacc aacagtcatt gcggtacact     3180

acctggacca gaccgaacag tgggagaagt tcggcataga gaagaggcaa gaggccctgg     3240

agctcatcaa gaaagggtac acccagcagc tggccttcaa acagcccagc tctgcctatg     3300

ctgccttcaa caaccggccc cccagcacct ggctgacagc ctacgtggtc aaggtcttct     3360

ctctagctgc caacctcatc gccatcgact ctcacgtcct gtgtggggct gttaaatggt     3420

tgattctgga gaaacagaag ccggatggtg tctttcagga ggatgggccc gtgattcacc     3480

aagaaatgat tggtggcttc cggaacgcca aggaggcaga tgtgtcactc acagccttcg     3540

tcctcatcgc actgcaggaa gccagggaca tctgtgaggg gcaggtcaat agccttcctg     3600

ggagcatcaa caaggcaggg gagtatattg aagccagtta catgaacctg cagagaccat     3660

acacagtggc cattgctggg tatgccctgg ccctgatgaa caaactggag gaaccttacc     3720

tcggcaagtt tctgaacaca gccaaagatc ggaaccgctg ggaggagcct gaccagcagc     3780

tctacaacgt agaggccaca tcctacgccc tcctggccct gctgctgctg aaagactttg     3840

actctgtgcc ccctgtagtg cgctggctca atgagcaaag atactacgga ggcggctatg     3900

gctccaccca ggctaccttc atggtattcc aagccttggc ccaatatcaa acagatgtcc     3960

ctgaccataa ggacttgaac atggatgtgt ccttccacct ccccagccgt agctctgcaa     4020

ccacgtttcg cctgctctgg gaaaatggca acctcctgcg atcggaagag accaagcaaa     4080

atgaggcctt ctctctaaca gccaaaggaa aaggccgagg cacattgtcg gtggtggcag     4140

tgtatcatgc caaactcaaa agcaaagtca cctgcaagaa gtttgacctc agggtcagca     4200

taagaccagc ccctgagaca gccaagaagc ccgaggaagc caagaatacc atgttccttg     4260

aaatctgcac caagtacttg ggagatgtgg acgccactat gtccatcctg gacatctcca     4320

tgatgactgg ctttgctcca gacacaaagg acctggaact gctggcctct ggagtagata     4380

gatacatctc caagtacgag atgaacaaag ccttctccaa caagaacacc ctcatcatct     4440

acctagaaaa gatttcacac accgaagaag actgcctgac cttcaaagtt caccagtact     4500

ttaatgtggg acttatccag cccgggtcgg tcaaggtcta ctcctattac aacctcgagg     4560

aatcatgcac ccggttctat catccagaga aggacgatgg gatgctcagc aagctgtgcc     4620

acagtgaaat gtgccggtgt gctgaagaga actgcttcat gcaacagtca caggagaaga     4680

tcaacctgaa tgtccggcta gacaaggctt gtgagcccgg agtcgactat gtgtacaaga     4740

ccgagctaac caacatagag ctgttggatg attttgatga gtacaccatg accatccagc     4800

aggtcatcaa gtcaggctca gatgaggtgc aggcagggca gcaacgcaag ttcatcagcc     4860

acatcaagtg cagaaacgcc ctgaagctgc agaaagggaa gaagtacctc atgtggggcc     4920

tctcctctga cctctgggga gaaaagccca acaccagcta catcattggg aaggacacgt     4980

gggtggagca ctggcctgag gcagaagaat gccaggatca gaagtaccag aaacagtgcg     5040

aagaacttgg ggcattcaca gaatctatgg tggtttatgg ttgtcccaac tgactacagc     5100

ccagccctct aataaagctt cagttgtatt tcacccatc                            5139


<210>  33
<211>  36
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Synthetic Construct

<400>  33
atcaactcac ctgtaataaa gcagccgaaa ggctgc                                 36


<210>  34
<211>  22
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Synthetic Construct

<400>  34
tttattacag gtgagttgat gg                                                22


<210>  35
<211>  36
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Synthetic Construct

<400>  35
agaaattcta ctacatctaa gcagccgaaa ggctgc                                 36


<210>  36
<211>  22
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Synthetic Construct

<400>  36
ttagatgtag tagaatttct gg                                                22


<210>  37
<211>  36
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Synthetic Construct


<220>
<221>  modified_base
<222>  (1)..(1)
<223>  2'-O-methyladenosine phosphorothioate

<220>
<221>  modified_base
<222>  (2)..(2)
<223>  um

<220>
<221>  modified_base
<222>  (3)..(3)
<223>  cm

<220>
<221>  modified_base
<222>  (4)..(5)
<223>  2'-O-methyladenosine

<220>
<221>  modified_base
<222>  (6)..(6)
<223>  cm

<220>
<221>  modified_base
<222>  (7)..(7)
<223>  um

<220>
<221>  modified_base
<222>  (8)..(8)
<223>  2'-fluorocytidine

<220>
<221>  modified_base
<222>  (9)..(9)
<223>  2'-fluoroadenosine

<220>
<221>  modified_base
<222>  (10)..(11)
<223>  2'-fluorocytidine

<220>
<221>  modified_base
<222>  (12)..(12)
<223>  um

<220>
<221>  modified_base
<222>  (13)..(13)
<223>  gm

<220>
<221>  modified_base
<222>  (14)..(14)
<223>  um

<220>
<221>  modified_base
<222>  (15)..(16)
<223>  2'-O-methyladenosine

<220>
<221>  modified_base
<222>  (17)..(17)
<223>  um

<220>
<221>  modified_base
<222>  (18)..(20)
<223>  2'-O-methyladenosine

<220>
<221>  modified_base
<222>  (21)..(21)
<223>  gm

<220>
<221>  modified_base
<222>  (22)..(22)
<223>  cm

<220>
<221>  modified_base
<222>  (23)..(23)
<223>  2'-O-methyladenosine

<220>
<221>  modified_base
<222>  (24)..(24)
<223>  gm

<220>
<221>  modified_base
<222>  (25)..(26)
<223>  cm

<220>
<221>  modified_base
<222>  (27)..(27)
<223>  gm

<220>
<221>  modified_base
<222>  (28)..(30)
<223>  2'aminodiethoxymethanol-Adenine-GalNAc

<220>
<221>  modified_base
<222>  (31)..(32)
<223>  gm

<220>
<221>  modified_base
<222>  (33)..(33)
<223>  cm

<220>
<221>  modified_base
<222>  (34)..(34)
<223>  um

<220>
<221>  modified_base
<222>  (35)..(35)
<223>  gm

<220>
<221>  modified_base
<222>  (36)..(36)
<223>  cm

<400>  37
aucaacucac cuguaauaaa gcagccgaaa ggcugc                                 36


<210>  38
<211>  22
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Synthetic Construct


<220>
<221>  modified_base
<222>  (1)..(1)
<223>  5'Methoxy, Phosphonate-4'oxy- 2'-O-methyluridine phosporothioate

<220>
<221>  modified_base
<222>  (2)..(2)
<223>  2'-fluorouridine phosphorothioate

<220>
<221>  modified_base
<222>  (3)..(3)
<223>  2'-fluorouridine

<220>
<221>  modified_base
<222>  (4)..(4)
<223>  2'-fluoroadenosine

<220>
<221>  modified_base
<222>  (5)..(5)
<223>  2'-fluorouridine

<220>
<221>  modified_base
<222>  (6)..(6)
<223>  um

<220>
<221>  modified_base
<222>  (7)..(7)
<223>  2'-fluoroadenosine

<220>
<221>  modified_base
<222>  (8)..(8)
<223>  cm

<220>
<221>  modified_base
<222>  (9)..(9)
<223>  2'-O-methyladenosine

<220>
<221>  modified_base
<222>  (10)..(10)
<223>  2'-fluoroguanosine

<220>
<221>  modified_base
<222>  (11)..(11)
<223>  gm

<220>
<221>  modified_base
<222>  (12)..(12)
<223>  um

<220>
<221>  modified_base
<222>  (13)..(13)
<223>  gm

<220>
<221>  modified_base
<222>  (14)..(14)
<223>  2'-fluoroadenosine

<220>
<221>  modified_base
<222>  (15)..(15)
<223>  gm

<220>
<221>  modified_base
<222>  (16)..(17)
<223>  um

<220>
<221>  modified_base
<222>  (18)..(18)
<223>  gm

<220>
<221>  modified_base
<222>  (19)..(19)
<223>  2'-O-methyladenosine

<220>
<221>  modified_base
<222>  (20)..(20)
<223>  2'-O-methyluridine phosphorothioate

<220>
<221>  modified_base
<222>  (21)..(21)
<223>  2'-O-methylguanosine phosphorothioate

<220>
<221>  modified_base
<222>  (22)..(22)
<223>  gm

<400>  38
uuuauuacag gugaguugau gg                                                22


<210>  39
<211>  36
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Synthetic Construct


<220>
<221>  modified_base
<222>  (1)..(1)
<223>  2'-O-methyladenosine phosphorothioate

<220>
<221>  modified_base
<222>  (2)..(2)
<223>  gm

<220>
<221>  modified_base
<222>  (3)..(3)
<223>  2'-fluoroadenosine

<220>
<221>  modified_base
<222>  (4)..(5)
<223>  2'-O-methyladenosine

<220>
<221>  modified_base
<222>  (6)..(7)
<223>  um

<220>
<221>  modified_base
<222>  (8)..(8)
<223>  2'-fluorocytidine

<220>
<221>  modified_base
<222>  (9)..(9)
<223>  2'-fluorouridine

<220>
<221>  modified_base
<222>  (10)..(10)
<223>  2'-fluoroadenosine

<220>
<221>  modified_base
<222>  (11)..(11)
<223>  cm

<220>
<221>  modified_base
<222>  (12)..(12)
<223>  2'-fluorouridine

<220>
<221>  modified_base
<222>  (13)..(13)
<223>  2'-fluoroadenosine

<220>
<221>  modified_base
<222>  (14)..(14)
<223>  cm

<220>
<221>  modified_base
<222>  (15)..(15)
<223>  2'-O-methyladenosine

<220>
<221>  modified_base
<222>  (16)..(16)
<223>  um

<220>
<221>  modified_base
<222>  (17)..(17)
<223>  2'-fluorocytidine

<220>
<221>  modified_base
<222>  (18)..(18)
<223>  um

<220>
<221>  modified_base
<222>  (19)..(20)
<223>  2'-O-methyladenosine

<220>
<221>  modified_base
<222>  (21)..(21)
<223>  gm

<220>
<221>  modified_base
<222>  (22)..(22)
<223>  cm

<220>
<221>  modified_base
<222>  (23)..(23)
<223>  2'-O-methyladenosine

<220>
<221>  modified_base
<222>  (24)..(24)
<223>  gm

<220>
<221>  modified_base
<222>  (25)..(26)
<223>  cm

<220>
<221>  modified_base
<222>  (27)..(27)
<223>  gm

<220>
<221>  modified_base
<222>  (28)..(30)
<223>  2'aminodiethoxymethanol-Adenine-GalNAc

<220>
<221>  modified_base
<222>  (31)..(32)
<223>  gm

<220>
<221>  modified_base
<222>  (33)..(33)
<223>  cm

<220>
<221>  modified_base
<222>  (34)..(34)
<223>  um

<220>
<221>  modified_base
<222>  (35)..(35)
<223>  gm

<220>
<221>  modified_base
<222>  (36)..(36)
<223>  cm

<400>  39
agaaauucua cuacaucuaa gcagccgaaa ggcugc                                 36


<210>  40
<211>  22
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Synthetic Construct


<220>
<221>  modified_base
<222>  (1)..(1)
<223>  5'Methoxy, Phosphonate-4'oxy- 2'-O-methyluridine phosporothioate

<220>
<221>  modified_base
<222>  (2)..(2)
<223>  2'-fluorouridine phosphorothioate

<220>
<221>  modified_base
<222>  (3)..(3)
<223>  2'-fluoroadenosine

<220>
<221>  modified_base
<222>  (4)..(4)
<223>  2'-fluoroguanosine

<220>
<221>  modified_base
<222>  (5)..(5)
<223>  2'-fluoroadenosine

<220>
<221>  modified_base
<222>  (6)..(6)
<223>  um

<220>
<221>  modified_base
<222>  (7)..(7)
<223>  2'-fluoroguanosine

<220>
<221>  modified_base
<222>  (8)..(8)
<223>  2'-fluorouridine

<220>
<221>  modified_base
<222>  (9)..(9)
<223>  2'-O-methyladenosine

<220>
<221>  modified_base
<222>  (10)..(10)
<223>  2'-fluoroguanosine

<220>
<221>  modified_base
<222>  (11)..(11)
<223>  um

<220>
<221>  modified_base
<222>  (12)..(12)
<223>  2'-fluoroadenosine

<220>
<221>  modified_base
<222>  (13)..(13)
<223>  gm

<220>
<221>  modified_base
<222>  (14)..(14)
<223>  2'-fluoroadenosine

<220>
<221>  modified_base
<222>  (15)..(15)
<223>  2'-O-methyladenosine

<220>
<221>  modified_base
<222>  (16)..(16)
<223>  2'-fluorouridine

<220>
<221>  modified_base
<222>  (17)..(18)
<223>  um

<220>
<221>  modified_base
<222>  (19)..(19)
<223>  2'-fluorocytidine

<220>
<221>  modified_base
<222>  (20)..(20)
<223>  2'-O-methyluridine phosphorothioate

<220>
<221>  modified_base
<222>  (21)..(21)
<223>  2'-O-methylguanosine phosphorothioate

<220>
<221>  modified_base
<222>  (22)..(22)
<223>  gm

<400>  40
uuagauguag uagaauuucu gg                                                22


<210>  41
<211>  36
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Synthetic Construct


<220>
<221>  modified_base
<222>  (1)..(1)
<223>  2'-O-methylcytidine phosphorothioate

<220>
<221>  modified_base
<222>  (2)..(2)
<223>  2'-O-methyladenosine

<220>
<221>  modified_base
<222>  (3)..(3)
<223>  gm

<220>
<221>  modified_base
<222>  (4)..(4)
<223>  cm

<220>
<221>  modified_base
<222>  (5)..(5)
<223>  um

<220>
<221>  modified_base
<222>  (6)..(7)
<223>  2'-O-methyladenosine

<220>
<221>  modified_base
<222>  (8)..(9)
<223>  2'-fluoroadenosine

<220>
<221>  modified_base
<222>  (10)..(10)
<223>  2'-fluoroguanosine

<220>
<221>  modified_base
<222>  (11)..(11)
<223>  2'-fluoroadenosine

<220>
<221>  modified_base
<222>  (12)..(12)
<223>  cm

<220>
<221>  modified_base
<222>  (13)..(15)
<223>  um

<220>
<221>  modified_base
<222>  (16)..(16)
<223>  gm

<220>
<221>  modified_base
<222>  (17)..(17)
<223>  2'-O-methyladenosine

<220>
<221>  modified_base
<222>  (18)..(18)
<223>  cm

<220>
<221>  modified_base
<222>  (19)..(19)
<223>  um

<220>
<221>  modified_base
<222>  (20)..(20)
<223>  2'-O-methyladenosine

<220>
<221>  modified_base
<222>  (21)..(21)
<223>  gm

<220>
<221>  modified_base
<222>  (22)..(22)
<223>  cm

<220>
<221>  modified_base
<222>  (23)..(23)
<223>  2'-O-methyladenosine

<220>
<221>  modified_base
<222>  (24)..(24)
<223>  gm

<220>
<221>  modified_base
<222>  (25)..(26)
<223>  cm

<220>
<221>  modified_base
<222>  (27)..(27)
<223>  gm

<220>
<221>  modified_base
<222>  (28)..(30)
<223>  2'aminodiethoxymethanol-Adenine-GalNAc

<220>
<221>  modified_base
<222>  (31)..(32)
<223>  gm

<220>
<221>  modified_base
<222>  (33)..(33)
<223>  cm

<220>
<221>  modified_base
<222>  (34)..(34)
<223>  um

<220>
<221>  modified_base
<222>  (35)..(35)
<223>  gm

<220>
<221>  modified_base
<222>  (36)..(36)
<223>  cm

<400>  41
cagcuaaaag acuuugacua gcagccgaaa ggcugc                                 36


<210>  42
<211>  22
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Synthetic Construct


<220>
<221>  modified_base
<222>  (1)..(1)
<223>  5'Methoxy, Phosphonate-4'oxy- 2'-O-methyluridine phosporothioate

<220>
<221>  modified_base
<222>  (2)..(2)
<223>  2'-fluoroadenosine phosphorothioate

<220>
<221>  modified_base
<222>  (3)..(3)
<223>  2'-fluoroguanosine

<220>
<221>  modified_base
<222>  (4)..(4)
<223>  2'-fluorouridine

<220>
<221>  modified_base
<222>  (5)..(5)
<223>  2'-fluorocytidine

<220>
<221>  modified_base
<222>  (6)..(6)
<223>  2'-O-methyladenosine

<220>
<221>  modified_base
<222>  (7)..(7)
<223>  2'-fluoroadenosine

<220>
<221>  modified_base
<222>  (8)..(8)
<223>  2'-O-methyladenosine

<220>
<221>  modified_base
<222>  (9)..(9)
<223>  gm

<220>
<221>  modified_base
<222>  (10)..(10)
<223>  2'-fluorouridine

<220>
<221>  modified_base
<222>  (11)..(11)
<223>  cm

<220>
<221>  modified_base
<222>  (12)..(13)
<223>  um

<220>
<221>  modified_base
<222>  (14)..(14)
<223>  2'-fluorouridine

<220>
<221>  modified_base
<222>  (15)..(15)
<223>  um

<220>
<221>  modified_base
<222>  (16)..(16)
<223>  2'-O-methyladenosine

<220>
<221>  modified_base
<222>  (17)..(17)
<223>  gm

<220>
<221>  modified_base
<222>  (18)..(18)
<223>  cm

<220>
<221>  modified_base
<222>  (19)..(19)
<223>  um

<220>
<221>  modified_base
<222>  (20)..(21)
<223>  2'-O-methylguanosine phosphorothioat

<220>
<221>  modified_base
<222>  (22)..(22)
<223>  gm

<400>  42
uagucaaagu cuuuuagcug gg                                                22


<210>  43
<211>  36
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Synthetic Construct


<220>
<221>  modified_base
<222>  (1)..(1)
<223>  2'-O-methylguanosine phosphorothioate

<220>
<221>  modified_base
<222>  (2)..(2)
<223>  cm

<220>
<221>  modified_base
<222>  (3)..(3)
<223>  um

<220>
<221>  modified_base
<222>  (4)..(7)
<223>  2'-O-methyladenosine

<220>
<221>  modified_base
<222>  (8)..(8)
<223>  2'-fluoroguanosine

<220>
<221>  modified_base
<222>  (9)..(9)
<223>  2'-fluoroadenosine

<220>
<221>  modified_base
<222>  (10)..(10)
<223>  2'-fluorocytidine

<220>
<221>  modified_base
<222>  (11)..(11)
<223>  2'-fluorouridine

<220>
<221>  modified_base
<222>  (12)..(13)
<223>  um

<220>
<221>  modified_base
<222>  (14)..(14)
<223>  gm

<220>
<221>  modified_base
<222>  (15)..(15)
<223>  2'-O-methyladenosine

<220>
<221>  modified_base
<222>  (16)..(16)
<223>  cm

<220>
<221>  modified_base
<222>  (17)..(19)
<223>  um

<220>
<221>  modified_base
<222>  (20)..(20)
<223>  2'-O-methyladenosine

<220>
<221>  modified_base
<222>  (21)..(21)
<223>  gm

<220>
<221>  modified_base
<222>  (22)..(22)
<223>  cm

<220>
<221>  modified_base
<222>  (23)..(23)
<223>  2'-O-methyladenosine

<220>
<221>  modified_base
<222>  (24)..(24)
<223>  gm

<220>
<221>  modified_base
<222>  (25)..(26)
<223>  cm

<220>
<221>  modified_base
<222>  (27)..(27)
<223>  gm

<220>
<221>  modified_base
<222>  (28)..(30)
<223>  2'aminodiethoxymethanol-Adenine-GalNAc

<220>
<221>  modified_base
<222>  (31)..(32)
<223>  gm

<220>
<221>  modified_base
<222>  (33)..(33)
<223>  cm

<220>
<221>  modified_base
<222>  (34)..(34)
<223>  um

<220>
<221>  modified_base
<222>  (35)..(35)
<223>  gm

<220>
<221>  modified_base
<222>  (36)..(36)
<223>  cm

<400>  43
gcuaaaagac uuugacuuua gcagccgaaa ggcugc                                 36


<210>  44
<211>  22
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Synthetic Construct


<220>
<221>  modified_base
<222>  (1)..(1)
<223>  5'Methoxy, Phosphonate-4'oxy- 2'-O-methyluridine phosporothioate

<220>
<221>  modified_base
<222>  (2)..(2)
<223>  2'-fluoroadenosine phosphorothioate

<220>
<221>  modified_base
<222>  (3)..(4)
<223>  2'-fluoroadenosine

<220>
<221>  modified_base
<222>  (5)..(5)
<223>  2'-fluoroguanosine

<220>
<221>  modified_base
<222>  (6)..(6)
<223>  um

<220>
<221>  modified_base
<222>  (7)..(7)
<223>  2'-fluorocytidine

<220>
<221>  modified_base
<222>  (8)..(9)
<223>  2'-O-methyladenosine

<220>
<221>  modified_base
<222>  (10)..(10)
<223>  2'-fluoroadenosine

<220>
<221>  modified_base
<222>  (11)..(11)
<223>  gm

<220>
<221>  modified_base
<222>  (12)..(12)
<223>  um

<220>
<221>  modified_base
<222>  (13)..(13)
<223>  cm

<220>
<221>  modified_base
<222>  (14)..(14)
<223>  2'-fluorouridine

<220>
<221>  modified_base
<222>  (15)..(17)
<223>  um

<220>
<221>  modified_base
<222>  (18)..(18)
<223>  2'-O-methyladenosine

<220>
<221>  modified_base
<222>  (19)..(19)
<223>  gm

<220>
<221>  modified_base
<222>  (20)..(20)
<223>  2'-O-methylcytidine phosphorothioate

<220>
<221>  modified_base
<222>  (21)..(21)
<223>  2'-O-methylguanosine phosphorothioate

<220>
<221>  modified_base
<222>  (22)..(22)
<223>  gm

<400>  44
uaaagucaaa gucuuuuagc gg                                                22


<210>  45
<211>  36
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Synthetic Construct


<220>
<221>  modified_base
<222>  (1)..(1)
<223>  2'-O-methylcytidine phosphorothioate

<220>
<221>  modified_base
<222>  (2)..(2)
<223>  um

<220>
<221>  modified_base
<222>  (3)..(3)
<223>  cm

<220>
<221>  modified_base
<222>  (4)..(5)
<223>  2'-O-methyladenosine

<220>
<221>  modified_base
<222>  (6)..(6)
<223>  um

<220>
<221>  modified_base
<222>  (7)..(7)
<223>  gm

<220>
<221>  modified_base
<222>  (8)..(9)
<223>  2'-fluoroadenosine

<220>
<221>  modified_base
<222>  (10)..(10)
<223>  2'-fluorocytidine

<220>
<221>  modified_base
<222>  (11)..(11)
<223>  2'-fluoroadenosine

<220>
<221>  modified_base
<222>  (12)..(12)
<223>  gm

<220>
<221>  modified_base
<222>  (13)..(13)
<223>  2'-O-methyladenosine

<220>
<221>  modified_base
<222>  (14)..(14)
<223>  gm

<220>
<221>  modified_base
<222>  (15)..(15)
<223>  2'-O-methyladenosine

<220>
<221>  modified_base
<222>  (16)..(16)
<223>  um

<220>
<221>  modified_base
<222>  (17)..(17)
<223>  2'-O-methyladenosine

<220>
<221>  modified_base
<222>  (18)..(18)
<223>  cm

<220>
<221>  modified_base
<222>  (19)..(19)
<223>  um

<220>
<221>  modified_base
<222>  (20)..(20)
<223>  2'-O-methyladenosine

<220>
<221>  modified_base
<222>  (21)..(21)
<223>  gm

<220>
<221>  modified_base
<222>  (22)..(22)
<223>  cm

<220>
<221>  modified_base
<222>  (23)..(23)
<223>  2'-O-methyladenosine

<220>
<221>  modified_base
<222>  (24)..(24)
<223>  gm

<220>
<221>  modified_base
<222>  (25)..(26)
<223>  cm

<220>
<221>  modified_base
<222>  (27)..(27)
<223>  gm

<220>
<221>  modified_base
<222>  (28)..(30)
<223>  2'aminodiethoxymethanol-Adenine-GalNAc

<220>
<221>  modified_base
<222>  (31)..(32)
<223>  gm

<220>
<221>  modified_base
<222>  (33)..(33)
<223>  cm

<220>
<221>  modified_base
<222>  (34)..(34)
<223>  um

<220>
<221>  modified_base
<222>  (35)..(35)
<223>  gm

<220>
<221>  modified_base
<222>  (36)..(36)
<223>  cm

<400>  45
cucaaugaac agagauacua gcagccgaaa ggcugc                                 36


<210>  46
<211>  22
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Synthetic Construct


<220>
<221>  modified_base
<222>  (1)..(1)
<223>  5'Methoxy, Phosphonate-4'oxy- 2'-O-methyluridine phosporothioate

<220>
<221>  modified_base
<222>  (2)..(2)
<223>  2'-fluoroadenosine phosphorothioate

<220>
<221>  modified_base
<222>  (3)..(3)
<223>  2'-fluoroguanosine

<220>
<221>  modified_base
<222>  (4)..(4)
<223>  2'-fluorouridine

<220>
<221>  modified_base
<222>  (5)..(5)
<223>  2'-fluoroadenosine

<220>
<221>  modified_base
<222>  (6)..(6)
<223>  um

<220>
<221>  modified_base
<222>  (7)..(7)
<223>  2'-fluorocytidine

<220>
<221>  modified_base
<222>  (8)..(8)
<223>  um

<220>
<221>  modified_base
<222>  (9)..(9)
<223>  cm

<220>
<221>  modified_base
<222>  (10)..(10)
<223>  2'-fluorouridine

<220>
<221>  modified_base
<222>  (11)..(11)
<223>  gm

<220>
<221>  modified_base
<222>  (12)..(13)
<223>  um

<220>
<221>  modified_base
<222>  (14)..(14)
<223>  2'-fluorocytidine

<220>
<221>  modified_base
<222>  (15)..(15)
<223>  2'-O-methyladenosine

<220>
<221>  modified_base
<222>  (16)..(17)
<223>  um

<220>
<221>  modified_base
<222>  (18)..(18)
<223>  gm

<220>
<221>  modified_base
<222>  (19)..(19)
<223>  2'-O-methyladenosine

<220>
<221>  modified_base
<222>  (20)..(21)
<223>  2'-O-methylguanosine phosphorothioate

<220>
<221>  modified_base
<222>  (22)..(22)
<223>  gm

<400>  46
uaguaucucu guucauugag gg                                                22


<210>  47
<211>  36
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Synthetic Construct


<220>
<221>  modified_base
<222>  (1)..(1)
<223>  2'-O-methyluridine phosphorothioate

<220>
<221>  modified_base
<222>  (2)..(2)
<223>  cm

<220>
<221>  modified_base
<222>  (3)..(4)
<223>  2'-O-methyladenosine

<220>
<221>  modified_base
<222>  (5)..(5)
<223>  cm

<220>
<221>  modified_base
<222>  (6)..(6)
<223>  um

<220>
<221>  modified_base
<222>  (7)..(7)
<223>  cm

<220>
<221>  modified_base
<222>  (8)..(8)
<223>  2'-fluoroadenosine

<220>
<221>  modified_base
<222>  (9)..(10)
<223>  2'-fluorocytidine

<220>
<221>  modified_base
<222>  (11)..(11)
<223>  2'-fluorouridine

<220>
<221>  modified_base
<222>  (12)..(12)
<223>  gm

<220>
<221>  modified_base
<222>  (13)..(13)
<223>  um

<220>
<221>  modified_base
<222>  (14)..(15)
<223>  2'-O-methyladenosine

<220>
<221>  modified_base
<222>  (16)..(16)
<223>  um

<220>
<221>  modified_base
<222>  (17)..(20)
<223>  2'-O-methyladenosine

<220>
<221>  modified_base
<222>  (21)..(21)
<223>  gm

<220>
<221>  modified_base
<222>  (22)..(22)
<223>  cm

<220>
<221>  modified_base
<222>  (23)..(23)
<223>  2'-O-methyladenosine

<220>
<221>  modified_base
<222>  (24)..(24)
<223>  gm

<220>
<221>  modified_base
<222>  (25)..(26)
<223>  cm

<220>
<221>  modified_base
<222>  (27)..(27)
<223>  gm

<220>
<221>  modified_base
<222>  (28)..(30)
<223>  2'aminodiethoxymethanol-Adenine-GalNAc

<220>
<221>  modified_base
<222>  (31)..(32)
<223>  gm

<220>
<221>  modified_base
<222>  (33)..(33)
<223>  cm

<220>
<221>  modified_base
<222>  (34)..(34)
<223>  um

<220>
<221>  modified_base
<222>  (35)..(35)
<223>  gm

<220>
<221>  modified_base
<222>  (36)..(36)
<223>  cm

<400>  47
ucaacucacc uguaauaaaa gcagccgaaa ggcugc                                 36


<210>  48
<211>  22
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Synthetic Construct


<220>
<221>  modified_base
<222>  (1)..(1)
<223>  5'Methoxy, Phosphonate-4'oxy- 2'-O-methyluridine phosporothioate

<220>
<221>  modified_base
<222>  (2)..(2)
<223>  2'-fluorouridine phosphorothioate

<220>
<221>  modified_base
<222>  (3)..(4)
<223>  2'-fluorouridine

<220>
<221>  modified_base
<222>  (5)..(5)
<223>  2'-fluoroadenosine

<220>
<221>  modified_base
<222>  (6)..(6)
<223>  um

<220>
<221>  modified_base
<222>  (7)..(7)
<223>  2'-fluorouridine

<220>
<221>  modified_base
<222>  (8)..(8)
<223>  2'-O-methyladenosine

<220>
<221>  modified_base
<222>  (9)..(9)
<223>  cm

<220>
<221>  modified_base
<222>  (10)..(10)
<223>  2'-fluoroadenosine

<220>
<221>  modified_base
<222>  (11)..(12)
<223>  gm

<220>
<221>  modified_base
<222>  (13)..(13)
<223>  um

<220>
<221>  modified_base
<222>  (14)..(14)
<223>  2'-fluoroguanosine

<220>
<221>  modified_base
<222>  (15)..(15)
<223>  2'-O-methyladenosine

<220>
<221>  modified_base
<222>  (16)..(16)
<223>  gm

<220>
<221>  modified_base
<222>  (17)..(18)
<223>  um

<220>
<221>  modified_base
<222>  (19)..(19)
<223>  gm

<220>
<221>  modified_base
<222>  (20)..(20)
<223>  2'-O-methyladenosine phosphorothioate

<220>
<221>  modified_base
<222>  (21)..(21)
<223>  2'-O-methylguanosine phosphorothioate

<220>
<221>  modified_base
<222>  (22)..(22)
<223>  gm

<400>  48
uuuuauuaca ggugaguuga gg                                                22


<210>  49
<211>  36
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Synthetic Construct


<220>
<221>  modified_base
<222>  (1)..(1)
<223>  2'-O-methyluridine phosphorothioate

<220>
<221>  modified_base
<222>  (2)..(2)
<223>  gm

<220>
<221>  modified_base
<222>  (3)..(3)
<223>  2'-O-methyladenosine

<220>
<221>  modified_base
<222>  (4)..(5)
<223>  gm

<220>
<221>  modified_base
<222>  (6)..(6)
<223>  2'-O-methyladenosine

<220>
<221>  modified_base
<222>  (7)..(7)
<223>  gm

<220>
<221>  modified_base
<222>  (8)..(9)
<223>  2'-fluoroadenosine

<220>
<221>  modified_base
<222>  (10)..(11)
<223>  2'-fluorouridine

<220>
<221>  modified_base
<222>  (12)..(12)
<223>  gm

<220>
<221>  modified_base
<222>  (13)..(13)
<223>  cm

<220>
<221>  modified_base
<222>  (14)..(15)
<223>  um

<220>
<221>  modified_base
<222>  (16)..(16)
<223>  cm

<220>
<221>  modified_base
<222>  (17)..(17)
<223>  2'-O-methyladenosine

<220>
<221>  modified_base
<222>  (18)..(18)
<223>  um

<220>
<221>  modified_base
<222>  (19)..(20)
<223>  2'-O-methyladenosine

<220>
<221>  modified_base
<222>  (21)..(21)
<223>  gm

<220>
<221>  modified_base
<222>  (22)..(22)
<223>  cm

<220>
<221>  modified_base
<222>  (23)..(23)
<223>  2'-O-methyladenosine

<220>
<221>  modified_base
<222>  (24)..(24)
<223>  gm

<220>
<221>  modified_base
<222>  (25)..(26)
<223>  cm

<220>
<221>  modified_base
<222>  (27)..(27)
<223>  gm

<220>
<221>  modified_base
<222>  (28)..(30)
<223>  2'aminodiethoxymethanol-Adenine-GalNAc

<220>
<221>  modified_base
<222>  (31)..(32)
<223>  gm

<220>
<221>  modified_base
<222>  (33)..(33)
<223>  cm

<220>
<221>  modified_base
<222>  (34)..(34)
<223>  um

<220>
<221>  modified_base
<222>  (35)..(35)
<223>  gm

<220>
<221>  modified_base
<222>  (36)..(36)
<223>  cm

<400>  49
ugaggagaau ugcuucauaa gcagccgaaa ggcugc                                 36


<210>  50
<211>  22
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Synthetic Construct


<220>
<221>  modified_base
<222>  (1)..(1)
<223>  5'Methoxy, Phosphonate-4'oxy- 2'-O-methyluridine phosporothioate

<220>
<221>  modified_base
<222>  (2)..(2)
<223>  2'-fluorouridine phosphorothioate

<220>
<221>  modified_base
<222>  (3)..(3)
<223>  2'-fluoroadenosine

<220>
<221>  modified_base
<222>  (4)..(4)
<223>  2'-fluorouridine

<220>
<221>  modified_base
<222>  (5)..(5)
<223>  2'-fluoroguanosine

<220>
<221>  modified_base
<222>  (6)..(6)
<223>  2'-O-methyladenosine

<220>
<221>  modified_base
<222>  (7)..(7)
<223>  2'-fluoroadenosine

<220>
<221>  modified_base
<222>  (8)..(8)
<223>  gm

<220>
<221>  modified_base
<222>  (9)..(9)
<223>  cm

<220>
<221>  modified_base
<222>  (10)..(10)
<223>  2'-fluoroadenosine

<220>
<221>  modified_base
<222>  (11)..(11)
<223>  2'-O-methyladenosine

<220>
<221>  modified_base
<222>  (12)..(13)
<223>  um

<220>
<221>  modified_base
<222>  (14)..(14)
<223>  2'-fluorocytidine

<220>
<221>  modified_base
<222>  (15)..(15)
<223>  um

<220>
<221>  modified_base
<222>  (16)..(17)
<223>  cm

<220>
<221>  modified_base
<222>  (18)..(18)
<223>  um

<220>
<221>  modified_base
<222>  (19)..(19)
<223>  cm

<220>
<221>  modified_base
<222>  (20)..(20)
<223>  2'-O-methyladenosine phosphorothioate

<220>
<221>  modified_base
<222>  (21)..(21)
<223>  2'-O-methylguanosine phosphorothioate

<220>
<221>  modified_base
<222>  (22)..(22)
<223>  gm

<400>  50
uuaugaagca auucuccuca gg                                                22


<210>  51
<211>  36
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Synthetic Construct


<220>
<221>  modified_base
<222>  (1)..(1)
<223>  2'-O-methylguanosine phosphorothioate

<220>
<221>  modified_base
<222>  (2)..(2)
<223>  gm

<220>
<221>  modified_base
<222>  (3)..(3)
<223>  2'-O-methyladenosine

<220>
<221>  modified_base
<222>  (4)..(4)
<223>  gm

<220>
<221>  modified_base
<222>  (5)..(6)
<223>  2'-O-methyladenosine

<220>
<221>  modified_base
<222>  (7)..(7)
<223>  um

<220>
<221>  modified_base
<222>  (8)..(8)
<223>  2'-fluorouridine

<220>
<221>  modified_base
<222>  (9)..(9)
<223>  2'-fluoroguanosine

<220>
<221>  modified_base
<222>  (10)..(10)
<223>  2'-fluorocytidine

<220>
<221>  modified_base
<222>  (11)..(11)
<223>  2'-fluorouridine

<220>
<221>  modified_base
<222>  (12)..(12)
<223>  um

<220>
<221>  modified_base
<222>  (13)..(13)
<223>  cm

<220>
<221>  modified_base
<222>  (14)..(14)
<223>  2'-O-methyladenosine

<220>
<221>  modified_base
<222>  (15)..(15)
<223>  um

<220>
<221>  modified_base
<222>  (16)..(16)
<223>  2'-O-methyladenosine

<220>
<221>  modified_base
<222>  (17)..(17)
<223>  cm

<220>
<221>  modified_base
<222>  (18)..(20)
<223>  2'-O-methyladenosine

<220>
<221>  modified_base
<222>  (21)..(21)
<223>  gm

<220>
<221>  modified_base
<222>  (22)..(22)
<223>  cm

<220>
<221>  modified_base
<222>  (23)..(23)
<223>  2'-O-methyladenosine

<220>
<221>  modified_base
<222>  (24)..(24)
<223>  gm

<220>
<221>  modified_base
<222>  (25)..(26)
<223>  cm

<220>
<221>  modified_base
<222>  (27)..(27)
<223>  gm

<220>
<221>  modified_base
<222>  (28)..(30)
<223>  2'aminodiethoxymethanol-Adenine-GalNAc

<220>
<221>  modified_base
<222>  (31)..(32)
<223>  gm

<220>
<221>  modified_base
<222>  (33)..(33)
<223>  cm

<220>
<221>  modified_base
<222>  (34)..(34)
<223>  um

<220>
<221>  modified_base
<222>  (35)..(35)
<223>  gm

<220>
<221>  modified_base
<222>  (36)..(36)
<223>  cm

<400>  51
ggagaauugc uucauacaaa gcagccgaaa ggcugc                                 36


<210>  52
<211>  22
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Synthetic Construct


<220>
<221>  modified_base
<222>  (1)..(1)
<223>  5'Methoxy, Phosphonate-4'oxy- 2'-O-methyluridine phosporothioate

<220>
<221>  modified_base
<222>  (2)..(2)
<223>  2'-fluorouridine phosphorothioate

<220>
<221>  modified_base
<222>  (3)..(3)
<223>  2'-fluorouridine

<220>
<221>  modified_base
<222>  (4)..(4)
<223>  2'-fluoroguanosine

<220>
<221>  modified_base
<222>  (5)..(5)
<223>  2'-fluorouridine

<220>
<221>  modified_base
<222>  (6)..(6)
<223>  2'-O-methyladenosine

<220>
<221>  modified_base
<222>  (7)..(7)
<223>  2'-fluorouridine

<220>
<221>  modified_base
<222>  (8)..(8)
<223>  gm

<220>
<221>  modified_base
<222>  (9)..(9)
<223>  2'-O-methyladenosine

<220>
<221>  modified_base
<222>  (10)..(10)
<223>  2'-fluoroadenosine

<220>
<221>  modified_base
<222>  (11)..(11)
<223>  gm

<220>
<221>  modified_base
<222>  (12)..(12)
<223>  cm

<220>
<221>  modified_base
<222>  (13)..(13)
<223>  2'-O-methyladenosine

<220>
<221>  modified_base
<222>  (14)..(14)
<223>  2'-fluoroadenosine

<220>
<221>  modified_base
<222>  (15)..(16)
<223>  um

<220>
<221>  modified_base
<222>  (17)..(17)
<223>  cm

<220>
<221>  modified_base
<222>  (18)..(18)
<223>  um

<220>
<221>  modified_base
<222>  (19)..(19)
<223>  cm

<220>
<221>  modified_base
<222>  (20)..(20)
<223>  2'-O-methylcytidine phosphorothioate

<220>
<221>  modified_base
<222>  (21)..(21)
<223>  2'-O-methylguanosine phosphorothioate

<220>
<221>  modified_base
<222>  (22)..(22)
<223>  gm

<400>  52
uuuguaugaa gcaauucucc gg                                                22


<210>  53
<211>  36
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Synthetic Construct


<220>
<221>  modified_base
<222>  (1)..(1)
<223>  2'-O-methyladenosine phosphorothioate

<220>
<221>  modified_base
<222>  (2)..(2)
<223>  gm

<220>
<221>  modified_base
<222>  (3)..(3)
<223>  2'-O-methyladenosine

<220>
<221>  modified_base
<222>  (4)..(4)
<223>  um

<220>
<221>  modified_base
<222>  (5)..(7)
<223>  2'-O-methyladenosine

<220>
<221>  modified_base
<222>  (8)..(8)
<223>  2'-fluoroguanosine

<220>
<221>  modified_base
<222>  (9)..(9)
<223>  2'-fluorocytidine

<220>
<221>  modified_base
<222>  (10)..(11)
<223>  2'-fluorouridine

<220>
<221>  modified_base
<222>  (12)..(12)
<223>  cm

<220>
<221>  modified_base
<222>  (13)..(13)
<223>  2'-O-methyladenosine

<220>
<221>  modified_base
<222>  (14)..(14)
<223>  gm

<220>
<221>  modified_base
<222>  (15)..(16)
<223>  um

<220>
<221>  modified_base
<222>  (17)..(17)
<223>  2'-O-methyladenosine

<220>
<221>  modified_base
<222>  (18)..(18)
<223>  um

<220>
<221>  modified_base
<222>  (19)..(20)
<223>  2'-O-methyladenosine

<220>
<221>  modified_base
<222>  (21)..(21)
<223>  gm

<220>
<221>  modified_base
<222>  (22)..(22)
<223>  cm

<220>
<221>  modified_base
<222>  (23)..(23)
<223>  2'-O-methyladenosine

<220>
<221>  modified_base
<222>  (24)..(24)
<223>  gm

<220>
<221>  modified_base
<222>  (25)..(26)
<223>  cm

<220>
<221>  modified_base
<222>  (27)..(27)
<223>  gm

<220>
<221>  modified_base
<222>  (28)..(30)
<223>  2'aminodiethoxymethanol-Adenine-GalNAc

<220>
<221>  modified_base
<222>  (31)..(32)
<223>  gm

<220>
<221>  modified_base
<222>  (33)..(33)
<223>  cm

<220>
<221>  modified_base
<222>  (34)..(34)
<223>  um

<220>
<221>  modified_base
<222>  (35)..(35)
<223>  gm

<220>
<221>  modified_base
<222>  (36)..(36)
<223>  cm

<400>  53
agauaaagcu ucaguuauaa gcagccgaaa ggcugc                                 36


<210>  54
<211>  22
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Synthetic Construct


<220>
<221>  modified_base
<222>  (1)..(1)
<223>  5'Methoxy, Phosphonate-4'oxy- 2'-O-methyluridine phosporothioate

<220>
<221>  modified_base
<222>  (2)..(2)
<223>  2'-fluorouridine phosphorothioate

<220>
<221>  modified_base
<222>  (3)..(3)
<223>  2'-fluoroadenosine

<220>
<221>  modified_base
<222>  (4)..(4)
<223>  2'-fluorouridine

<220>
<221>  modified_base
<222>  (5)..(5)
<223>  2'-fluoroadenosine

<220>
<221>  modified_base
<222>  (6)..(6)
<223>  2'-O-methyladenosine

<220>
<221>  modified_base
<222>  (7)..(7)
<223>  2'-fluorocytidine

<220>
<221>  modified_base
<222>  (8)..(8)
<223>  um

<220>
<221>  modified_base
<222>  (9)..(9)
<223>  gm

<220>
<221>  modified_base
<222>  (10)..(10)
<223>  2'-fluoroadenosine

<220>
<221>  modified_base
<222>  (11)..(11)
<223>  2'-O-methyladenosine

<220>
<221>  modified_base
<222>  (12)..(12)
<223>  gm

<220>
<221>  modified_base
<222>  (13)..(13)
<223>  cm

<220>
<221>  modified_base
<222>  (14)..(14)
<223>  2'-fluorouridine

<220>
<221>  modified_base
<222>  (15)..(16)
<223>  um

<220>
<221>  modified_base
<222>  (17)..(17)
<223>  2'-O-methyladenosine

<220>
<221>  modified_base
<222>  (18)..(18)
<223>  um

<220>
<221>  modified_base
<222>  (19)..(19)
<223>  cm

<220>
<221>  modified_base
<222>  (20)..(20)
<223>  2'-O-methyluridine phosphorothioate

<220>
<221>  modified_base
<222>  (21)..(21)
<223>  2'-O-methylguanosine phosphorothioate

<220>
<221>  modified_base
<222>  (22)..(22)
<223>  gm

<400>  54
uuauaacuga agcuuuaucu gg                                                22


<210>  55
<211>  21
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Synthetic Construct

<400>  55
aatgaggcct tctctctaac a                                                 21


<210>  56
<211>  20
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Synthetic Construct

<400>  56
acttcttgca ggtgactttg                                                   20


<210>  57
<211>  20
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Synthetic Construct

<400>  57
caaactttgc tttccctggt                                                   20


<210>  58
<211>  21
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Synthetic Construct

<400>  58
caacaaagtc tggcctgtat c                                                 21


<210>  59
<211>  21
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Synthetic Construct

<400>  59
ccaaactcag catcaacaca c                                                 21


<210>  60
<211>  18
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Synthetic Construct

<400>  60
ctgcatggtc ctggtagc                                                     18


<210>  61
<211>  22
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Synthetic Construct

<400>  61
gccaaagatc aactcacctg ta                                                22


<210>  62
<211>  20
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Synthetic Construct

<400>  62
agacatagtg gcatcctggt                                                   20


<210>  63
<211>  19
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Synthetic Construct

<400>  63
aatgaactgc aggacgagg                                                    19


<210>  64
<211>  21
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Synthetic Construct

<400>  64
aggtgagatg acaggagatc c                                                 21


<210>  65
<211>  21
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Synthetic Construct

<400>  65
ctttccttgg tcaggcagta t                                                 21


<210>  66
<211>  20
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Synthetic Construct

<400>  66
caacacttcg tggagtcctt                                                   20


<210>  67
<211>  5126
<212>  DNA
<213>  Macaca fascicularis

<400>  67
aaagccaact ccagcagtca ctgctcactc ctccccatcc tctccctctg tccctctgtc       60

cctctgaccc tgcactgtcc cagcaccatg ggactcacct caggtcccag cctgctgctc      120

ctgctactaa tccacctccc cctggctctg gggactccca tgtactctat gatcacccca      180

aacgtcttgc ggctggagag tgaggagacc gtggtgctgg aggcccatga cgcgaatggg      240

gatgttccgg tcactgtcac tgtccacgac ttcccaggca aaaaactggt gctgtccagt      300

gagaagaccg tgctgacccc tgccaccagc cacatgggca gcgtcaccat caggatccca      360

gccaacaagg agttcaagtc agaaaagggg cacaacaagt tcgtgactgt gcaggccacc      420

ttcggggccc aagtggtgga gaaggtggta ctggtcagcc ttcagagcgg gtacctcttc      480

atccagacag acaagaccat ctacacccct ggctccacag ttctctgtcg gatcttcacc      540

gtcaaccaca agctgctacc cgtgggccgg acggtcgtgg tcaacattga gaacccggac      600

ggcatcccgg tcaagcagga ctccttgtct tctcagaacc aatttggcat cttgcccttg      660

tcttgggaca ttccggaact cgtcaacatg ggccagtgga agatccgagc ctactatgaa      720

aattcgccgc aacaggtctt ctccactgag tttgaggtga aggagtacgt gctgcccagt      780

ttcgaggtca tagtggagcc tacagagaaa ttctactaca tctataacca gaagggcctg      840

gaggtcacca tcaccgccag gttcctctat ggaaagaaag tggagggaac tgcctttgtc      900

atcttcggga tccaggatgg cgagcagagg atttccctgc ctgaatccct caagcgcatc      960

cagattgagg atggctcagg agacgccgtg ctgagccgga aggtactgct ggacggggtg     1020

cagaatcccc gaccggaaga cctagtgggg aagtccttgt atgtgtctgt caccgttatc     1080

ctgcactcag gcagtgacat ggtgcaggcg gagcgcagcg ggatccccat cgtgacctct     1140

ccctaccaga tccacttcac caagacgccc aagtacttca aaccaggaat gccctttgac     1200

ctcatggtgt tcgtgacgaa ccccgatggc tctccagcct accgagtccc cgtggcagtc     1260

cagggcgagg acgctgtgca gtctctaacc cagggagacg gcgtggccaa actcagcatc     1320

aacacacacc ccagccagaa gcccttgagc atcacggtgc gcacgaagaa gcgggagctc     1380

tcggaggcgg agcaggctac caggaccatg gaggctcagc cctacagcac cgtgggcaac     1440

tccaacaatt acctgcatct ctcagtgcca cgtgcagagc tcagacctgg ggagaccctc     1500

aacgtcaact tcctcctgcg aatggaccgc acccaggagg ccaagatccg ctactacacc     1560

tacctgatta tgaacaaagg caagctgttg aaggtgggac gccaggtgcg agagcctggc     1620

caggacctgg tggtgctgcc cctgtccatc accaccgact tcatcccttc cttccgcctg     1680

gtggcctact acacgctgat cggcgccaac ggccagaggg aagtggtggc cgactccgtg     1740

tgggtggacg tcaaggactc ttgcgtgggc tcgctggtgg taaaaagcgg ccagtcagaa     1800

gacaggcagc ctttacccgg gcagcagatg accctgaaga tagagggtga ccacggggcc     1860

cgggtgggac tggtggctgt ggacaagggc gtgtttgtgc tgaataagaa gaacaagctg     1920

acgcagagta agatctggga cgtggtggag aaggcagaca tcggctgcac cccaggcagt     1980

gggaaggatt acgctggtgt cttctcggat gcaggcctga cctttgcgag cagcagtggc     2040

cagcagacgg cccagagggc agaacttcag tgcccacagc cagccgcccg ccgacgccgt     2100

tccgtgcagc tcgcggagaa gagaatggac aaagttggtc agtaccccaa ggagctgcgc     2160

aagtgctgcg agcacggtat gcgggagaac cccatgaggt tctcatgcca gcgccggacc     2220

cgttacatca ccctggacga ggcgtgcaag aaggccttcc tggactgctg caactacatc     2280

accgagctgc ggcggcagca cgcgcgggcc agtcacctgg gcctggccag gagtaacctg     2340

gatgaggaca tcatcgcaga agagaacatc gtttcccgaa gtgagttccc agagagttgg     2400

ctgtggaaga ttgaagagtt gaaagaggca ccgaaaaacg gaatctccac gaagctcatg     2460

aatatatttt tgaaagactc catcaccacg tgggagattc tggccgtgag cttgtcagac     2520

aagaaaggga tctgtgtggc agaccccttc gaggtcacag taatgcagga cttcttcatc     2580

gacctgcggc taccctactc tgttgttcga aacgagcagg tggaaatccg agctgttctc     2640

tacaattacc ggcagaacca agagctcaag gtgagggtgg aactactcca caatccagcc     2700

ttctgcagcc tggccaccgc caagaggcgt caccagcaga ccgtaaccat cccccccaag     2760

tcctcgctgt ccgttcctta tgtcatcgtg cccctaaaga ccggccagca ggaagtggaa     2820

gtcaaggctg ccgtctacca ttttttcatc agtgacggtg tcaggaagtc cctgaaggtc     2880

gtgccggaag gaatcagaat gaacaaaact gtggctgttc gcacgctgga tccagaacgc     2940

ctgggccagg aaggagtgca gagagaggac gtcccacctg cagacctcag tgaccaagtc     3000

ccggacaccg agtctgagac cagaattctc ctgcaaggga ccccggtggc ccagatgaca     3060

gaggatgcca tcgatgcgga acggctgaag cacctcatcg tgaccccctc gggctgcgga     3120

gaacagaaca tgatcaccat gacgcccaca gtcatcgctg tgcattacct ggatgaaacg     3180

gaacagtggg agaagttcgg cccggagaag cggcaggggg ccttggagct catcaagaag     3240

gggtacaccc agcagctggc cttcagacaa cccagctctg cctttgcggc cttcctgaac     3300

cgggcaccca gcacctggct gaccgcctac gtggtcaagg tcttctctct ggctgtcaac     3360

ctcattgcca tcgactccca ggtcctctgc ggggctgtta aatggctgat cctggagaag     3420

cagaagcccg acggggtctt ccaggaggat gcgcccgtga tacatcaaga aatgactggt     3480

ggattccgga acaccaacga gaaagacatg gccctcacgg cctttgttct catctcgctg     3540

caagaggcta aagagatttg cgaggagcag gtcaacagcc tgcccggcag catcactaaa     3600

gcaggagact tccttgaagc caactacatg aacctacaga gatcctacac tgtggccatc     3660

gctgcctatg ccctggccca gatgggcagg ctgaagggac ctcttctcaa caaatttctg     3720

accacagcca aagataagaa ccgctgggag gagcctggtc agcagctcta caatgtggag     3780

gccacatcct atgccctctt ggccctactg cagctaaaag actttgactt tgtgcctccc     3840

gtcgtgcgtt ggctcaatga acagagatac tacggtggtg gctatggctc tacccaggcc     3900

accttcatgg tgttccaagc cttggctcaa taccaaaagg atgtccctga tcacaaggaa     3960

ctgaacctgg atgtgtccct ccaactgccc agtcgcagct ccaagatcat ccaccgtatc     4020

cactgggaat ctgccagcct cctgcgatca gaagagacca aggaaaatga gggtttcaca     4080

gtcacagctg aaggaaaagg ccaaggcacc ttgtcggtag tgacaatgta ccatgctaag     4140

gccaaaggtc aactcacctg taataaattc gacctcaagg tcaccataaa accagcaccg     4200

gaaacagaaa agaggcctca ggatgccaag aacactatga tccttgagat ctgtaccagg     4260

taccggggag accaggatgc cactatgtct atactggaca tatccatgat gactggcttc     4320

gttccagaca cagatgacct caagcagctg gcaaacggcg ttgacagata catctccaag     4380

tatgagctgg acaaagcctt ctccgatagg aacaccctca tcatctacct ggacaaggtc     4440

tcacactctg aggatgactg tatagctttc aaagttcacc aatattttaa tgtagagctt     4500

atccagcctg gtgcagtcaa ggtctacgcc tattacaacc tggcggaaag ctgtacccgg     4560

ttctaccacc cagaaaagga ggatggaaag ctgaacaagc tctgtcgtga tgagctgtgc     4620

cgctgtgctg aggagaattg cttcatacaa aagttggatg acaaagtcac cctggaagaa     4680

cggctggaca aggcctgtga gccaggagtg gactatgtgt acaagacccg actggtcaag     4740

gcccagctgt ccaatgactt tgacgagtac atcatggcca ttgagcagat catcaagtca     4800

ggctcggatg aggtgcaggt tggacaacag cgcacgttca tcagccccat caagtgcagg     4860

gaagccctga agctggagga gaggaaacac tacctcatgt ggggtctctc ctccgatttc     4920

tggggagaga aacccaatct cagctacatc atcgggaagg acacctgggt ggagcactgg     4980

cccgaggagg acgaatgcca agatgaagag aaccagaaac aatgccagga cctcggcacc     5040

ttcactgaga acatggttgt ctttgggtgc cccaactgac cacaccccca ttcccccact     5100

cccaataaag cttcagttat atttca                                          5126


