                         SEQUENCE LISTING

<110>  Cue Biopharma, Inc.
 
<120>  ANTIGEN-PRESENTING POLYPEPTIDES WITH CHEMICAL CONJUGATION SITES 
       AND METHODS OF USE THEREOF

<130>  2910-26 PCT

<150>  63/178,397
<151>  2021-04-22

<150>  63/177,943
<151>  2021-04-21

<160>  308   

<170>  PatentIn version 3.5

<210>  1
<211>  353
<212>  PRT
<213>  Homo sapiens

<400>  1

Ala Ser Pro Thr Ser Pro Lys Val Phe Pro Leu Ser Leu Cys Ser Thr 
1               5                   10                  15      


Gln Pro Asp Gly Asn Val Val Ile Ala Cys Leu Val Gln Gly Phe Phe 
            20                  25                  30          


Pro Gln Glu Pro Leu Ser Val Thr Trp Ser Glu Ser Gly Gln Gly Val 
        35                  40                  45              


Thr Ala Arg Asn Phe Pro Pro Ser Gln Asp Ala Ser Gly Asp Leu Tyr 
    50                  55                  60                  


Thr Thr Ser Ser Gln Leu Thr Leu Pro Ala Thr Gln Cys Leu Ala Gly 
65                  70                  75                  80  


Lys Ser Val Thr Cys His Val Lys His Tyr Thr Asn Pro Ser Gln Asp 
                85                  90                  95      


Val Thr Val Pro Cys Pro Val Pro Ser Thr Pro Pro Thr Pro Ser Pro 
            100                 105                 110         


Ser Thr Pro Pro Thr Pro Ser Pro Ser Cys Cys His Pro Arg Leu Ser 
        115                 120                 125             


Leu His Arg Pro Ala Leu Glu Asp Leu Leu Leu Gly Ser Glu Ala Asn 
    130                 135                 140                 


Leu Thr Cys Thr Leu Thr Gly Leu Arg Asp Ala Ser Gly Val Thr Phe 
145                 150                 155                 160 


Thr Trp Thr Pro Ser Ser Gly Lys Ser Ala Val Gln Gly Pro Pro Glu 
                165                 170                 175     


Arg Asp Leu Cys Gly Cys Tyr Ser Val Ser Ser Val Leu Pro Gly Cys 
            180                 185                 190         


Ala Glu Pro Trp Asn His Gly Lys Thr Phe Thr Cys Thr Ala Ala Tyr 
        195                 200                 205             


Pro Glu Ser Lys Thr Pro Leu Thr Ala Thr Leu Ser Lys Ser Gly Asn 
    210                 215                 220                 


Thr Phe Arg Pro Glu Val His Leu Leu Pro Pro Pro Ser Glu Glu Leu 
225                 230                 235                 240 


Ala Leu Asn Glu Leu Val Thr Leu Thr Cys Leu Ala Arg Gly Phe Ser 
                245                 250                 255     


Pro Lys Asp Val Leu Val Arg Trp Leu Gln Gly Ser Gln Glu Leu Pro 
            260                 265                 270         


Arg Glu Lys Tyr Leu Thr Trp Ala Ser Arg Gln Glu Pro Ser Gln Gly 
        275                 280                 285             


Thr Thr Thr Phe Ala Val Thr Ser Ile Leu Arg Val Ala Ala Glu Asp 
    290                 295                 300                 


Trp Lys Lys Gly Asp Thr Phe Ser Cys Met Val Gly His Glu Ala Leu 
305                 310                 315                 320 


Pro Leu Ala Phe Thr Gln Lys Thr Ile Asp Arg Leu Ala Gly Lys Pro 
                325                 330                 335     


Thr His Val Asn Val Ser Val Val Met Ala Glu Val Asp Gly Thr Cys 
            340                 345                 350         


Tyr 
    


<210>  2
<211>  383
<212>  PRT
<213>  Homo sapiens

<400>  2

Pro Thr Lys Ala Pro Asp Val Phe Pro Ile Ile Ser Gly Cys Arg His 
1               5                   10                  15      


Pro Lys Asp Asn Ser Pro Val Val Leu Ala Cys Leu Ile Thr Gly Tyr 
            20                  25                  30          


His Pro Thr Ser Val Thr Val Thr Trp Tyr Met Gly Thr Gln Ser Gln 
        35                  40                  45              


Pro Gln Arg Thr Phe Pro Glu Ile Gln Arg Arg Asp Ser Tyr Tyr Met 
    50                  55                  60                  


Thr Ser Ser Gln Leu Ser Thr Pro Leu Gln Gln Trp Arg Gln Gly Glu 
65                  70                  75                  80  


Tyr Lys Cys Val Val Gln His Thr Ala Ser Lys Ser Lys Lys Glu Ile 
                85                  90                  95      


Phe Arg Trp Pro Glu Ser Pro Lys Ala Gln Ala Ser Ser Val Pro Thr 
            100                 105                 110         


Ala Gln Pro Gln Ala Glu Gly Ser Leu Ala Lys Ala Thr Thr Ala Pro 
        115                 120                 125             


Ala Thr Thr Arg Asn Thr Gly Arg Gly Gly Glu Glu Lys Lys Lys Glu 
    130                 135                 140                 


Lys Glu Lys Glu Glu Gln Glu Glu Arg Glu Thr Lys Thr Pro Glu Cys 
145                 150                 155                 160 


Pro Ser His Thr Gln Pro Leu Gly Val Tyr Leu Leu Thr Pro Ala Val 
                165                 170                 175     


Gln Asp Leu Trp Leu Arg Asp Lys Ala Thr Phe Thr Cys Phe Val Val 
            180                 185                 190         


Gly Ser Asp Leu Lys Asp Ala His Leu Thr Trp Glu Val Ala Gly Lys 
        195                 200                 205             


Val Pro Thr Gly Gly Val Glu Glu Gly Leu Leu Glu Arg His Ser Asn 
    210                 215                 220                 


Gly Ser Gln Ser Gln His Ser Arg Leu Thr Leu Pro Arg Ser Leu Trp 
225                 230                 235                 240 


Asn Ala Gly Thr Ser Val Thr Cys Thr Leu Asn His Pro Ser Leu Pro 
                245                 250                 255     


Pro Gln Arg Leu Met Ala Leu Arg Glu Pro Ala Ala Gln Ala Pro Val 
            260                 265                 270         


Lys Leu Ser Leu Asn Leu Leu Ala Ser Ser Asp Pro Pro Glu Ala Ala 
        275                 280                 285             


Ser Trp Leu Leu Cys Glu Val Ser Gly Phe Ser Pro Pro Asn Ile Leu 
    290                 295                 300                 


Leu Met Trp Leu Glu Asp Gln Arg Glu Val Asn Thr Ser Gly Phe Ala 
305                 310                 315                 320 


Pro Ala Arg Pro Pro Pro Gln Pro Arg Ser Thr Thr Phe Trp Ala Trp 
                325                 330                 335     


Ser Val Leu Arg Val Pro Ala Pro Pro Ser Pro Gln Pro Ala Thr Tyr 
            340                 345                 350         


Thr Cys Val Val Ser His Glu Asp Ser Arg Thr Leu Leu Asn Ala Ser 
        355                 360                 365             


Arg Ser Leu Glu Val Ser Tyr Val Thr Asp His Gly Pro Met Lys 
    370                 375                 380             


<210>  3
<211>  222
<212>  PRT
<213>  Homo sapiens

<400>  3

Ala Asp Pro Cys Asp Ser Asn Pro Arg Gly Val Ser Ala Tyr Leu Ser 
1               5                   10                  15      


Arg Pro Ser Pro Phe Asp Leu Phe Ile Arg Lys Ser Pro Thr Ile Thr 
            20                  25                  30          


Cys Leu Val Val Asp Leu Ala Pro Ser Lys Gly Thr Val Asn Leu Thr 
        35                  40                  45              


Trp Ser Arg Ala Ser Gly Lys Pro Val Asn His Ser Thr Arg Lys Glu 
    50                  55                  60                  


Glu Lys Gln Arg Asn Gly Thr Leu Thr Val Thr Ser Thr Leu Pro Val 
65                  70                  75                  80  


Gly Thr Arg Asp Trp Ile Glu Gly Glu Thr Tyr Gln Cys Arg Val Thr 
                85                  90                  95      


His Pro His Leu Pro Arg Ala Leu Met Arg Ser Thr Thr Lys Thr Ser 
            100                 105                 110         


Gly Pro Arg Ala Ala Pro Glu Val Tyr Ala Phe Ala Thr Pro Glu Trp 
        115                 120                 125             


Pro Gly Ser Arg Asp Lys Arg Thr Leu Ala Cys Leu Ile Gln Asn Phe 
    130                 135                 140                 


Met Pro Glu Asp Ile Ser Val Gln Trp Leu His Asn Glu Val Gln Leu 
145                 150                 155                 160 


Pro Asp Ala Arg His Ser Thr Thr Gln Pro Arg Lys Thr Lys Gly Ser 
                165                 170                 175     


Gly Phe Phe Val Phe Ser Arg Leu Glu Val Thr Arg Ala Glu Trp Glu 
            180                 185                 190         


Gln Lys Asp Glu Phe Ile Cys Arg Ala Val His Glu Ala Ala Ser Pro 
        195                 200                 205             


Ser Gln Thr Val Gln Arg Ala Val Ser Val Asn Pro Gly Lys 
    210                 215                 220         


<210>  4
<211>  227
<212>  PRT
<213>  Homo sapiens

<400>  4

Asp Lys Thr His Thr Cys Pro Pro Cys Pro Ala Pro Glu Leu Leu Gly 
1               5                   10                  15      


Gly Pro Ser Val Phe Leu Phe Pro Pro Lys Pro Lys Asp Thr Leu Met 
            20                  25                  30          


Ile Ser Arg Thr Pro Glu Val Thr Cys Val Val Val Asp Val Ser His 
        35                  40                  45              


Glu Asp Pro Glu Val Lys Phe Asn Trp Tyr Val Asp Gly Val Glu Val 
    50                  55                  60                  


His Asn Ala Lys Thr Lys Pro Arg Glu Glu Gln Tyr Asn Ser Thr Tyr 
65                  70                  75                  80  


Arg Val Val Ser Val Leu Thr Val Leu His Gln Asp Trp Leu Asn Gly 
                85                  90                  95      


Lys Glu Tyr Lys Cys Lys Val Ser Asn Lys Ala Leu Pro Ala Pro Ile 
            100                 105                 110         


Glu Lys Thr Ile Ser Lys Ala Lys Gly Gln Pro Arg Glu Pro Gln Val 
        115                 120                 125             


Tyr Thr Leu Pro Pro Ser Arg Glu Glu Met Thr Lys Asn Gln Val Ser 
    130                 135                 140                 


Leu Thr Cys Leu Val Lys Gly Phe Tyr Pro Ser Asp Ile Ala Val Glu 
145                 150                 155                 160 


Trp Glu Ser Asn Gly Gln Pro Glu Asn Asn Tyr Lys Thr Thr Pro Pro 
                165                 170                 175     


Val Leu Asp Ser Asp Gly Ser Phe Phe Leu Tyr Ser Lys Leu Thr Val 
            180                 185                 190         


Asp Lys Ser Arg Trp Gln Gln Gly Asn Val Phe Ser Cys Ser Val Met 
        195                 200                 205             


His Glu Ala Leu His Asn His Tyr Thr Gln Lys Ser Leu Ser Leu Ser 
    210                 215                 220                 


Pro Gly Lys 
225         


<210>  5
<211>  227
<212>  PRT
<213>  Homo sapiens

<400>  5

Asp Lys Thr His Thr Cys Pro Pro Cys Pro Ala Pro Glu Leu Leu Gly 
1               5                   10                  15      


Gly Pro Ser Val Phe Leu Phe Pro Pro Lys Pro Lys Asp Thr Leu Met 
            20                  25                  30          


Ile Ser Arg Thr Pro Glu Val Thr Cys Val Val Val Asp Val Ser His 
        35                  40                  45              


Glu Asp Pro Glu Val Lys Phe Asn Trp Tyr Val Asp Gly Val Glu Val 
    50                  55                  60                  


His Asn Ala Lys Thr Lys Pro Arg Glu Glu Gln Tyr Asn Ser Thr Tyr 
65                  70                  75                  80  


Arg Val Val Ser Val Leu Thr Val Leu His Gln Asp Trp Leu Asn Gly 
                85                  90                  95      


Lys Glu Tyr Lys Cys Lys Val Ser Asn Lys Ala Leu Pro Ala Pro Ile 
            100                 105                 110         


Glu Lys Thr Ile Ser Lys Ala Lys Gly Gln Pro Arg Glu Pro Gln Val 
        115                 120                 125             


Tyr Thr Leu Pro Pro Ser Arg Asp Glu Leu Thr Lys Asn Gln Val Ser 
    130                 135                 140                 


Leu Thr Cys Leu Val Lys Gly Phe Tyr Pro Ser Asp Ile Ala Val Glu 
145                 150                 155                 160 


Trp Glu Ser Asn Gly Gln Pro Glu Asn Asn Tyr Lys Thr Thr Pro Pro 
                165                 170                 175     


Val Leu Asp Ser Asp Gly Ser Phe Phe Leu Tyr Ser Lys Leu Thr Val 
            180                 185                 190         


Asp Lys Ser Arg Trp Gln Gln Gly Asn Val Phe Ser Cys Ser Val Met 
        195                 200                 205             


His Glu Ala Leu His Asn His Tyr Thr Gln Lys Ser Leu Ser Leu Ser 
    210                 215                 220                 


Pro Gly Lys 
225         


<210>  6
<211>  227
<212>  PRT
<213>  Homo sapiens

<400>  6

Asp Lys Thr His Thr Cys Pro Pro Cys Pro Ala Pro Glu Phe Glu Gly 
1               5                   10                  15      


Gly Pro Ser Val Phe Leu Phe Pro Pro Lys Pro Lys Asp Thr Leu Met 
            20                  25                  30          


Ile Ser Arg Thr Pro Glu Val Thr Cys Val Val Val Asp Val Ser His 
        35                  40                  45              


Glu Asp Pro Glu Val Lys Phe Asn Trp Tyr Val Asp Gly Val Glu Val 
    50                  55                  60                  


His Asn Ala Lys Thr Lys Pro Arg Glu Glu Gln Tyr Asn Ser Thr Tyr 
65                  70                  75                  80  


Arg Val Val Ser Val Leu Thr Val Leu His Gln Asp Trp Leu Asn Gly 
                85                  90                  95      


Lys Glu Tyr Lys Cys Lys Val Ser Asn Lys Ala Leu Pro Ala Ser Ile 
            100                 105                 110         


Glu Lys Thr Ile Ser Lys Ala Lys Gly Gln Pro Arg Glu Pro Gln Val 
        115                 120                 125             


Tyr Thr Leu Pro Pro Ser Arg Glu Glu Met Thr Lys Asn Gln Val Ser 
    130                 135                 140                 


Leu Thr Cys Leu Val Lys Gly Phe Tyr Pro Ser Asp Ile Ala Val Glu 
145                 150                 155                 160 


Trp Glu Ser Asn Gly Gln Pro Glu Asn Asn Tyr Lys Thr Thr Pro Pro 
                165                 170                 175     


Val Leu Asp Ser Asp Gly Ser Phe Phe Leu Tyr Ser Lys Leu Thr Val 
            180                 185                 190         


Asp Lys Ser Arg Trp Gln Gln Gly Asn Val Phe Ser Cys Ser Val Met 
        195                 200                 205             


His Glu Ala Leu His Asn His Tyr Thr Gln Lys Ser Leu Ser Leu Ser 
    210                 215                 220                 


Pro Gly Lys 
225         


<210>  7
<211>  227
<212>  PRT
<213>  Homo sapiens

<400>  7

Asp Lys Thr His Thr Cys Pro Pro Cys Pro Ala Pro Glu Leu Leu Gly 
1               5                   10                  15      


Gly Pro Ser Val Phe Leu Phe Pro Pro Lys Pro Lys Asp Thr Leu Met 
            20                  25                  30          


Ile Ser Arg Thr Pro Glu Val Thr Cys Val Val Val Asp Val Ser His 
        35                  40                  45              


Glu Asp Pro Glu Val Lys Phe Asn Trp Tyr Val Asp Gly Val Glu Val 
    50                  55                  60                  


His Asn Ala Lys Thr Lys Pro Arg Glu Glu Gln Tyr Ala Ser Thr Tyr 
65                  70                  75                  80  


Arg Val Val Ser Val Leu Thr Val Leu His Gln Asp Trp Leu Asn Gly 
                85                  90                  95      


Lys Glu Tyr Lys Cys Lys Val Ser Asn Lys Ala Leu Pro Ala Pro Ile 
            100                 105                 110         


Glu Lys Thr Ile Ser Lys Ala Lys Gly Gln Pro Arg Glu Pro Gln Val 
        115                 120                 125             


Tyr Thr Leu Pro Pro Ser Arg Glu Glu Met Thr Lys Asn Gln Val Ser 
    130                 135                 140                 


Leu Thr Cys Leu Val Lys Gly Phe Tyr Pro Ser Asp Ile Ala Val Glu 
145                 150                 155                 160 


Trp Glu Ser Asn Gly Gln Pro Glu Asn Asn Tyr Lys Thr Thr Pro Pro 
                165                 170                 175     


Val Leu Asp Ser Asp Gly Ser Phe Phe Leu Tyr Ser Lys Leu Thr Val 
            180                 185                 190         


Asp Lys Ser Arg Trp Gln Gln Gly Asn Val Phe Ser Cys Ser Val Met 
        195                 200                 205             


His Glu Ala Leu His Asn His Tyr Thr Gln Lys Ser Leu Ser Leu Ser 
    210                 215                 220                 


Pro Gly Lys 
225         


<210>  8
<211>  227
<212>  PRT
<213>  Homo sapiens

<400>  8

Asp Lys Thr His Thr Cys Pro Pro Cys Pro Ala Pro Glu Ala Ala Gly 
1               5                   10                  15      


Gly Pro Ser Val Phe Leu Phe Pro Pro Lys Pro Lys Asp Thr Leu Met 
            20                  25                  30          


Ile Ser Arg Thr Pro Glu Val Thr Cys Val Val Val Asp Val Ser His 
        35                  40                  45              


Glu Asp Pro Glu Val Lys Phe Asn Trp Tyr Val Asp Gly Val Glu Val 
    50                  55                  60                  


His Asn Ala Lys Thr Lys Pro Arg Glu Glu Gln Tyr Asn Ser Thr Tyr 
65                  70                  75                  80  


Arg Val Val Ser Val Leu Thr Val Leu His Gln Asp Trp Leu Asn Gly 
                85                  90                  95      


Lys Glu Tyr Lys Cys Lys Val Ser Asn Lys Ala Leu Pro Ala Pro Ile 
            100                 105                 110         


Glu Lys Thr Ile Ser Lys Ala Lys Gly Gln Pro Arg Glu Pro Gln Val 
        115                 120                 125             


Tyr Thr Leu Pro Pro Ser Arg Glu Glu Met Thr Lys Asn Gln Val Ser 
    130                 135                 140                 


Leu Thr Cys Leu Val Lys Gly Phe Tyr Pro Ser Asp Ile Ala Val Glu 
145                 150                 155                 160 


Trp Glu Ser Asn Gly Gln Pro Glu Asn Asn Tyr Lys Thr Thr Pro Pro 
                165                 170                 175     


Val Leu Asp Ser Asp Gly Ser Phe Phe Leu Tyr Ser Lys Leu Thr Val 
            180                 185                 190         


Asp Lys Ser Arg Trp Gln Gln Gly Asn Val Phe Ser Cys Ser Val Met 
        195                 200                 205             


His Glu Ala Leu His Asn His Tyr Thr Gln Lys Ser Leu Ser Leu Ser 
    210                 215                 220                 


Pro Gly Lys 
225         


<210>  9
<211>  325
<212>  PRT
<213>  Homo sapiens

<400>  9

Ser Thr Lys Gly Pro Ser Val Phe Pro Leu Ala Pro Cys Ser Arg Ser 
1               5                   10                  15      


Thr Ser Glu Ser Thr Ala Ala Leu Gly Cys Leu Val Lys Asp Tyr Phe 
            20                  25                  30          


Pro Glu Pro Val Thr Val Ser Trp Asn Ser Gly Ala Leu Thr Ser Gly 
        35                  40                  45              


Val His Thr Phe Pro Ala Val Leu Gln Ser Ser Gly Leu Tyr Ser Leu 
    50                  55                  60                  


Ser Ser Val Val Thr Val Pro Ser Ser Asn Phe Gly Thr Gln Thr Tyr 
65                  70                  75                  80  


Thr Cys Asn Val Asp His Lys Pro Ser Asn Thr Lys Val Asp Lys Thr 
                85                  90                  95      


Val Glu Arg Lys Cys Cys Val Glu Cys Pro Pro Cys Pro Ala Pro Pro 
            100                 105                 110         


Val Ala Gly Pro Ser Val Phe Leu Phe Pro Pro Lys Pro Lys Asp Thr 
        115                 120                 125             


Leu Met Ile Ser Arg Thr Pro Glu Val Thr Cys Val Val Val Asp Val 
    130                 135                 140                 


Ser His Glu Asp Pro Glu Val Gln Phe Asn Trp Tyr Val Asp Gly Val 
145                 150                 155                 160 


Glu Val His Asn Ala Lys Thr Lys Pro Arg Glu Glu Gln Phe Asn Ser 
                165                 170                 175     


Thr Phe Arg Val Val Ser Val Leu Thr Val Val His Gln Asp Trp Leu 
            180                 185                 190         


Asn Gly Lys Glu Tyr Lys Cys Lys Val Ser Asn Lys Gly Leu Pro Ala 
        195                 200                 205             


Pro Ile Glu Lys Thr Ile Ser Lys Thr Lys Gly Gln Pro Arg Glu Pro 
    210                 215                 220                 


Gln Val Tyr Thr Leu Pro Pro Ser Arg Glu Glu Met Thr Lys Asn Gln 
225                 230                 235                 240 


Val Ser Leu Thr Cys Leu Val Lys Gly Phe Tyr Pro Ser Asp Ile Ala 
                245                 250                 255     


Val Glu Trp Glu Ser Asn Gly Gln Pro Glu Asn Asn Tyr Lys Thr Thr 
            260                 265                 270         


Pro Pro Met Leu Asp Ser Asp Gly Ser Phe Phe Leu Tyr Ser Lys Leu 
        275                 280                 285             


Thr Val Asp Lys Ser Arg Trp Gln Gln Gly Asn Val Phe Ser Cys Ser 
    290                 295                 300                 


Val Met His Glu Ala Leu His Asn His Tyr Thr Gln Lys Ser Leu Ser 
305                 310                 315                 320 


Leu Ser Pro Gly Lys 
                325 


<210>  10
<211>  246
<212>  PRT
<213>  Homo sapiens

<400>  10

His Lys Pro Ser Asn Thr Lys Val Asp Lys Arg Val Glu Leu Lys Thr 
1               5                   10                  15      


Pro Leu Gly Asp Thr Thr His Thr Cys Pro Pro Cys Pro Ala Pro Glu 
            20                  25                  30          


Leu Leu Gly Gly Pro Ser Val Phe Leu Phe Pro Pro Lys Pro Lys Asp 
        35                  40                  45              


Thr Leu Met Ile Ser Arg Thr Pro Glu Val Thr Cys Val Val Val Asp 
    50                  55                  60                  


Val Ser His Glu Asp Pro Glu Val Lys Phe Asn Trp Tyr Val Asp Gly 
65                  70                  75                  80  


Val Glu Val His Asn Ala Lys Thr Lys Pro Arg Glu Glu Gln Tyr Asn 
                85                  90                  95      


Ser Thr Tyr Arg Val Val Ser Val Leu Thr Val Leu His Gln Asp Trp 
            100                 105                 110         


Leu Asn Gly Lys Glu Tyr Lys Cys Lys Val Ser Asn Lys Ala Leu Pro 
        115                 120                 125             


Ala Pro Ile Glu Lys Thr Ile Ser Lys Ala Lys Gly Gln Pro Arg Glu 
    130                 135                 140                 


Pro Gln Val Tyr Thr Leu Pro Pro Ser Arg Asp Glu Leu Thr Lys Asn 
145                 150                 155                 160 


Gln Val Ser Leu Thr Cys Leu Val Lys Gly Phe Tyr Pro Ser Asp Ile 
                165                 170                 175     


Ala Val Glu Trp Glu Ser Asn Gly Gln Pro Glu Asn Asn Tyr Lys Thr 
            180                 185                 190         


Thr Pro Pro Val Leu Asp Ser Asp Gly Ser Phe Phe Leu Tyr Ser Lys 
        195                 200                 205             


Leu Thr Val Asp Lys Ser Arg Trp Gln Gln Gly Asn Val Phe Ser Cys 
    210                 215                 220                 


Ser Val Met His Glu Ala Leu His Asn His Tyr Thr Gln Lys Ser Leu 
225                 230                 235                 240 


Ser Leu Ser Pro Gly Lys 
                245     


<210>  11
<211>  327
<212>  PRT
<213>  Homo sapiens

<400>  11

Ala Ser Thr Lys Gly Pro Ser Val Phe Pro Leu Ala Pro Cys Ser Arg 
1               5                   10                  15      


Ser Thr Ser Glu Ser Thr Ala Ala Leu Gly Cys Leu Val Lys Asp Tyr 
            20                  25                  30          


Phe Pro Glu Pro Val Thr Val Ser Trp Asn Ser Gly Ala Leu Thr Ser 
        35                  40                  45              


Gly Val His Thr Phe Pro Ala Val Leu Gln Ser Ser Gly Leu Tyr Ser 
    50                  55                  60                  


Leu Ser Ser Val Val Thr Val Pro Ser Ser Ser Leu Gly Thr Lys Thr 
65                  70                  75                  80  


Tyr Thr Cys Asn Val Asp His Lys Pro Ser Asn Thr Lys Val Asp Lys 
                85                  90                  95      


Arg Val Glu Ser Lys Tyr Gly Pro Pro Cys Pro Ser Cys Pro Ala Pro 
            100                 105                 110         


Glu Phe Leu Gly Gly Pro Ser Val Phe Leu Phe Pro Pro Lys Pro Lys 
        115                 120                 125             


Asp Thr Leu Met Ile Ser Arg Thr Pro Glu Val Thr Cys Val Val Val 
    130                 135                 140                 


Asp Val Ser Gln Glu Asp Pro Glu Val Gln Phe Asn Trp Tyr Val Asp 
145                 150                 155                 160 


Gly Val Glu Val His Asn Ala Lys Thr Lys Pro Arg Glu Glu Gln Phe 
                165                 170                 175     


Asn Ser Thr Tyr Arg Val Val Ser Val Leu Thr Val Leu His Gln Asp 
            180                 185                 190         


Trp Leu Asn Gly Lys Glu Tyr Lys Cys Lys Val Ser Asn Lys Gly Leu 
        195                 200                 205             


Pro Ser Ser Ile Glu Lys Thr Ile Ser Lys Ala Lys Gly Gln Pro Arg 
    210                 215                 220                 


Glu Pro Gln Val Tyr Thr Leu Pro Pro Ser Gln Glu Glu Met Thr Lys 
225                 230                 235                 240 


Asn Gln Val Ser Leu Thr Cys Leu Val Lys Gly Phe Tyr Pro Ser Asp 
                245                 250                 255     


Ile Ala Val Glu Trp Glu Ser Asn Gly Gln Pro Glu Asn Asn Tyr Lys 
            260                 265                 270         


Thr Thr Pro Pro Val Leu Asp Ser Asp Gly Ser Phe Phe Leu Tyr Ser 
        275                 280                 285             


Arg Leu Thr Val Asp Lys Ser Arg Trp Gln Glu Gly Asn Val Phe Ser 
    290                 295                 300                 


Cys Ser Val Met His Glu Ala Leu His Asn His Tyr Thr Gln Lys Ser 
305                 310                 315                 320 


Leu Ser Leu Ser Leu Gly Lys 
                325         


<210>  12
<211>  223
<212>  PRT
<213>  Homo sapiens

<400>  12

Pro Pro Cys Pro Ser Cys Pro Ala Pro Glu Phe Leu Gly Gly Pro Ser 
1               5                   10                  15      


Val Phe Leu Phe Pro Pro Lys Pro Lys Asp Thr Leu Met Ile Ser Arg 
            20                  25                  30          


Thr Pro Glu Val Thr Cys Val Val Val Asp Val Ser Gln Glu Asp Pro 
        35                  40                  45              


Glu Val Gln Phe Asn Trp Tyr Val Asp Gly Val Glu Val His Asn Ala 
    50                  55                  60                  


Lys Thr Lys Pro Arg Glu Glu Gln Phe Asn Ser Thr Tyr Arg Val Val 
65                  70                  75                  80  


Ser Val Leu Thr Val Leu His Gln Asp Trp Leu Asn Gly Lys Glu Tyr 
                85                  90                  95      


Lys Cys Lys Val Ser Asn Lys Gly Leu Pro Ser Ser Ile Glu Lys Thr 
            100                 105                 110         


Ile Ser Lys Ala Lys Gly Gln Pro Arg Glu Pro Gln Val Tyr Thr Leu 
        115                 120                 125             


Pro Pro Ser Gln Glu Glu Met Thr Lys Asn Gln Val Ser Leu Thr Cys 
    130                 135                 140                 


Leu Val Lys Gly Phe Tyr Pro Ser Asp Ile Ala Val Glu Trp Glu Ser 
145                 150                 155                 160 


Asn Gly Gln Pro Glu Asn Asn Tyr Lys Thr Thr Pro Pro Val Leu Asp 
                165                 170                 175     


Ser Asp Gly Ser Phe Phe Leu Tyr Ser Arg Leu Thr Val Asp Lys Ser 
            180                 185                 190         


Arg Trp Gln Glu Gly Asn Val Phe Ser Cys Ser Val Met His Glu Ala 
        195                 200                 205             


Leu His Asn His Tyr Thr Gln Lys Ser Leu Ser Leu Ser Pro Gly 
    210                 215                 220             


<210>  13
<211>  453
<212>  PRT
<213>  Homo sapiens

<400>  13

Gly Ser Ala Ser Ala Pro Thr Leu Phe Pro Leu Val Ser Cys Glu Asn 
1               5                   10                  15      


Ser Pro Ser Asp Thr Ser Ser Val Ala Val Gly Cys Leu Ala Gln Asp 
            20                  25                  30          


Phe Leu Pro Asp Ser Ile Thr Phe Ser Trp Lys Tyr Lys Asn Asn Ser 
        35                  40                  45              


Asp Ile Ser Ser Thr Arg Gly Phe Pro Ser Val Leu Arg Gly Gly Lys 
    50                  55                  60                  


Tyr Ala Ala Thr Ser Gln Val Leu Leu Pro Ser Lys Asp Val Met Gln 
65                  70                  75                  80  


Gly Thr Asp Glu His Val Val Cys Lys Val Gln His Pro Asn Gly Asn 
                85                  90                  95      


Lys Glu Lys Asn Val Pro Leu Pro Val Ile Ala Glu Leu Pro Pro Lys 
            100                 105                 110         


Val Ser Val Phe Val Pro Pro Arg Asp Gly Phe Phe Gly Asn Pro Arg 
        115                 120                 125             


Lys Ser Lys Leu Ile Cys Gln Ala Thr Gly Phe Ser Pro Arg Gln Ile 
    130                 135                 140                 


Gln Val Ser Trp Leu Arg Glu Gly Lys Gln Val Gly Ser Gly Val Thr 
145                 150                 155                 160 


Thr Asp Gln Val Gln Ala Glu Ala Lys Glu Ser Gly Pro Thr Thr Tyr 
                165                 170                 175     


Lys Val Thr Ser Thr Leu Thr Ile Lys Glu Ser Asp Trp Leu Gly Gln 
            180                 185                 190         


Ser Met Phe Thr Cys Arg Val Asp His Arg Gly Leu Thr Phe Gln Gln 
        195                 200                 205             


Asn Ala Ser Ser Met Cys Val Pro Asp Gln Asp Thr Ala Ile Arg Val 
    210                 215                 220                 


Phe Ala Ile Pro Pro Ser Phe Ala Ser Ile Phe Leu Thr Lys Ser Thr 
225                 230                 235                 240 


Lys Leu Thr Cys Leu Val Thr Asp Leu Thr Thr Tyr Asp Ser Val Thr 
                245                 250                 255     


Ile Ser Trp Thr Arg Gln Asn Gly Glu Ala Val Lys Thr His Thr Asn 
            260                 265                 270         


Ile Ser Glu Ser His Pro Asn Ala Thr Phe Ser Ala Val Gly Glu Ala 
        275                 280                 285             


Ser Ile Cys Glu Asp Asp Trp Asn Ser Gly Glu Arg Phe Thr Cys Thr 
    290                 295                 300                 


Val Thr His Thr Asp Leu Pro Ser Pro Leu Lys Gln Thr Ile Ser Arg 
305                 310                 315                 320 


Pro Lys Gly Val Ala Leu His Arg Pro Asp Val Tyr Leu Leu Pro Pro 
                325                 330                 335     


Ala Arg Glu Gln Leu Asn Leu Arg Glu Ser Ala Thr Ile Thr Cys Leu 
            340                 345                 350         


Val Thr Gly Phe Ser Pro Ala Asp Val Phe Val Gln Trp Met Gln Arg 
        355                 360                 365             


Gly Gln Pro Leu Ser Pro Glu Lys Tyr Val Thr Ser Ala Pro Met Pro 
    370                 375                 380                 


Glu Pro Gln Ala Pro Gly Arg Tyr Phe Ala His Ser Ile Leu Thr Val 
385                 390                 395                 400 


Ser Glu Glu Glu Trp Asn Thr Gly Glu Thr Tyr Thr Cys Val Val Ala 
                405                 410                 415     


His Glu Ala Leu Pro Asn Arg Val Thr Glu Arg Thr Val Asp Lys Ser 
            420                 425                 430         


Thr Gly Lys Pro Thr Leu Tyr Asn Val Ser Leu Val Met Ser Asp Thr 
        435                 440                 445             


Ala Gly Thr Cys Tyr 
    450             


<210>  14
<211>  112
<212>  PRT
<213>  Homo sapiens

<400>  14

Phe Thr Val Arg Glu Thr Ala Ser Thr Lys Gly Pro Ser Val Phe Pro 
1               5                   10                  15      


Leu Ala Pro Ser Ser Lys Ser Thr Ser Gly Gly Thr Ala Ala Leu Gly 
            20                  25                  30          


Cys Leu Val Lys Asp Tyr Phe Pro Glu Pro Val Thr Val Ser Trp Asn 
        35                  40                  45              


Ser Gly Ala Leu Thr Ser Gly Val His Thr Phe Pro Ala Val Leu Gln 
    50                  55                  60                  


Ser Ser Gly Leu Tyr Ser Leu Ser Ser Val Val Thr Val Pro Ser Ser 
65                  70                  75                  80  


Ser Leu Gly Thr Gln Thr Tyr Ile Cys Asn Val Asn His Lys Pro Ser 
                85                  90                  95      


Asn Thr Lys Val Asp Lys Lys Val Glu Pro Lys Ser Cys Asp Lys Thr 
            100                 105                 110         


<210>  15
<211>  106
<212>  PRT
<213>  Homo sapiens

<400>  15

Thr Val Ala Ala Pro Ser Val Phe Ile Phe Pro Pro Ser Asp Glu Gln 
1               5                   10                  15      


Leu Lys Ser Gly Thr Ala Ser Val Val Cys Leu Leu Asn Asn Phe Tyr 
            20                  25                  30          


Pro Arg Glu Ala Lys Val Gln Trp Lys Val Asp Asn Ala Leu Gln Ser 
        35                  40                  45              


Gly Asn Ser Gln Glu Ser Val Thr Glu Gln Asp Ser Lys Asp Ser Thr 
    50                  55                  60                  


Tyr Ser Leu Ser Ser Thr Leu Thr Leu Ser Lys Ala Asp Tyr Glu Lys 
65                  70                  75                  80  


His Lys Val Tyr Ala Cys Glu Val Thr His Gln Gly Leu Ser Ser Pro 
                85                  90                  95      


Val Thr Lys Ser Phe Asn Arg Gly Glu Cys 
            100                 105     


<210>  16
<211>  106
<212>  PRT
<213>  Homo sapiens

<400>  16

Gly Gln Pro Lys Ala Asn Pro Thr Val Thr Leu Phe Pro Pro Ser Ser 
1               5                   10                  15      


Glu Glu Leu Gln Ala Asn Lys Ala Thr Leu Val Cys Leu Ile Ser Asp 
            20                  25                  30          


Phe Tyr Pro Gly Ala Val Thr Val Ala Trp Lys Ala Asp Gly Ser Pro 
        35                  40                  45              


Val Lys Ala Gly Val Glu Thr Thr Lys Pro Ser Lys Gln Ser Asn Asn 
    50                  55                  60                  


Lys Tyr Ala Ala Ser Ser Tyr Leu Ser Leu Thr Pro Glu Gln Trp Lys 
65                  70                  75                  80  


Ser His Arg Ser Tyr Ser Cys Gln Val Thr His Glu Gly Ser Thr Val 
                85                  90                  95      


Glu Lys Thr Val Ala Pro Thr Glu Cys Ser 
            100                 105     


<210>  17
<211>  254
<212>  PRT
<213>  Homo sapiens

<400>  17

Met Ala Ile Ser Gly Val Pro Val Leu Gly Phe Phe Ile Ile Ala Val 
1               5                   10                  15      


Leu Met Ser Ala Gln Glu Ser Trp Ala Ile Lys Glu Glu His Val Ile 
            20                  25                  30          


Ile Gln Ala Glu Phe Tyr Leu Asn Pro Asp Gln Ser Gly Glu Phe Met 
        35                  40                  45              


Phe Asp Phe Asp Gly Asp Glu Ile Phe His Val Asp Met Ala Lys Lys 
    50                  55                  60                  


Glu Thr Val Trp Arg Leu Glu Glu Phe Gly Arg Phe Ala Ser Phe Glu 
65                  70                  75                  80  


Ala Gln Gly Ala Leu Ala Asn Ile Ala Val Asp Lys Ala Asn Leu Glu 
                85                  90                  95      


Ile Met Thr Lys Arg Ser Asn Tyr Thr Pro Ile Thr Asn Val Pro Pro 
            100                 105                 110         


Glu Val Thr Val Leu Thr Asn Ser Pro Val Glu Leu Arg Glu Pro Asn 
        115                 120                 125             


Val Leu Ile Cys Phe Ile Asp Lys Phe Thr Pro Pro Val Val Asn Val 
    130                 135                 140                 


Thr Trp Leu Arg Asn Gly Lys Pro Val Thr Thr Gly Val Ser Glu Thr 
145                 150                 155                 160 


Val Phe Leu Pro Arg Glu Asp His Leu Phe Arg Lys Phe His Tyr Leu 
                165                 170                 175     


Pro Phe Leu Pro Ser Thr Glu Asp Val Tyr Asp Cys Arg Val Glu His 
            180                 185                 190         


Trp Gly Leu Asp Glu Pro Leu Leu Lys His Trp Glu Phe Asp Ala Pro 
        195                 200                 205             


Ser Pro Leu Pro Glu Thr Thr Glu Asn Val Val Cys Ala Leu Gly Leu 
    210                 215                 220                 


Thr Val Gly Leu Val Gly Ile Ile Ile Gly Thr Ile Phe Ile Ile Lys 
225                 230                 235                 240 


Gly Leu Arg Lys Ser Asn Ala Ala Glu Arg Arg Gly Pro Leu 
                245                 250                 


<210>  18
<211>  266
<212>  PRT
<213>  Homo sapiens

<400>  18

Met Val Cys Leu Lys Leu Pro Gly Gly Ser Cys Met Thr Ala Leu Thr 
1               5                   10                  15      


Val Thr Leu Met Val Leu Ser Ser Pro Leu Ala Leu Ala Gly Asp Thr 
            20                  25                  30          


Arg Pro Arg Phe Leu Trp Gln Leu Lys Phe Glu Cys His Phe Phe Asn 
        35                  40                  45              


Gly Thr Glu Arg Val Arg Leu Leu Glu Arg Cys Ile Tyr Asn Gln Glu 
    50                  55                  60                  


Glu Ser Val Arg Phe Asp Ser Asp Val Gly Glu Tyr Arg Ala Val Thr 
65                  70                  75                  80  


Glu Leu Gly Arg Pro Asp Ala Glu Tyr Trp Asn Ser Gln Lys Asp Leu 
                85                  90                  95      


Leu Glu Gln Arg Arg Ala Ala Val Asp Thr Tyr Cys Arg His Asn Tyr 
            100                 105                 110         


Gly Val Gly Glu Ser Phe Thr Val Gln Arg Arg Val Glu Pro Lys Val 
        115                 120                 125             


Thr Val Tyr Pro Ser Lys Thr Gln Pro Leu Gln His His Asn Leu Leu 
    130                 135                 140                 


Val Cys Ser Val Ser Gly Phe Tyr Pro Gly Ser Ile Glu Val Arg Trp 
145                 150                 155                 160 


Phe Arg Asn Gly Gln Glu Glu Lys Ala Gly Val Val Ser Thr Gly Leu 
                165                 170                 175     


Ile Gln Asn Gly Asp Trp Thr Phe Gln Thr Leu Val Met Leu Glu Thr 
            180                 185                 190         


Val Pro Arg Ser Gly Glu Val Tyr Thr Cys Gln Val Glu His Pro Ser 
        195                 200                 205             


Val Thr Ser Pro Leu Thr Val Glu Trp Arg Ala Arg Ser Glu Ser Ala 
    210                 215                 220                 


Gln Ser Lys Met Leu Ser Gly Val Gly Gly Phe Val Leu Gly Leu Leu 
225                 230                 235                 240 


Phe Leu Gly Ala Gly Leu Phe Ile Tyr Phe Arg Asn Gln Lys Gly His 
                245                 250                 255     


Ser Gly Leu Gln Pro Thr Gly Phe Leu Ser 
            260                 265     


<210>  19
<211>  266
<212>  PRT
<213>  Homo sapiens

<400>  19

Met Val Cys Leu Lys Leu Pro Gly Gly Ser Cys Met Thr Ala Leu Thr 
1               5                   10                  15      


Val Thr Leu Met Val Leu Ser Ser Pro Leu Ala Leu Ala Gly Asp Thr 
            20                  25                  30          


Arg Pro Arg Phe Leu Trp Gln Leu Lys Phe Glu Cys His Phe Phe Asn 
        35                  40                  45              


Gly Thr Glu Arg Val Arg Leu Leu Glu Arg Cys Ile Tyr Asn Gln Glu 
    50                  55                  60                  


Glu Ser Val Arg Phe Asp Ser Asp Val Gly Glu Tyr Arg Ala Val Thr 
65                  70                  75                  80  


Glu Leu Gly Arg Pro Asp Ala Glu Tyr Trp Asn Ser Gln Lys Asp Leu 
                85                  90                  95      


Leu Glu Gln Arg Arg Ala Ala Val Asp Thr Tyr Cys Arg His Asn Tyr 
            100                 105                 110         


Gly Ala Val Glu Ser Phe Thr Val Gln Arg Arg Val Glu Pro Lys Val 
        115                 120                 125             


Thr Val Tyr Pro Ser Lys Thr Gln Pro Leu Gln His His Asn Leu Leu 
    130                 135                 140                 


Val Cys Ser Val Ser Gly Phe Tyr Pro Gly Ser Ile Glu Val Arg Trp 
145                 150                 155                 160 


Phe Arg Asn Gly Gln Glu Glu Lys Ala Gly Val Val Ser Thr Gly Leu 
                165                 170                 175     


Ile Gln Asn Gly Asp Trp Thr Phe Gln Thr Leu Val Met Leu Glu Thr 
            180                 185                 190         


Val Pro Arg Ser Gly Glu Val Tyr Thr Cys Gln Val Glu His Pro Ser 
        195                 200                 205             


Val Thr Ser Pro Leu Thr Val Glu Trp Arg Ala Arg Ser Glu Ser Ala 
    210                 215                 220                 


Gln Ser Lys Met Leu Ser Gly Val Gly Gly Phe Val Leu Gly Leu Leu 
225                 230                 235                 240 


Phe Leu Gly Ala Gly Leu Phe Ile Tyr Phe Arg Asn Gln Lys Gly His 
                245                 250                 255     


Ser Gly Leu Gln Pro Thr Gly Phe Leu Ser 
            260                 265     


<210>  20
<211>  266
<212>  PRT
<213>  Homo sapiens

<400>  20

Met Val Cys Leu Lys Leu Pro Gly Gly Ser Cys Met Thr Ala Leu Thr 
1               5                   10                  15      


Val Thr Leu Met Val Leu Ser Ser Pro Leu Ala Leu Ala Gly Asp Thr 
            20                  25                  30          


Arg Pro Arg Phe Leu Trp Gln Leu Lys Phe Glu Cys His Phe Phe Asn 
        35                  40                  45              


Gly Thr Glu Arg Val Arg Leu Leu Glu Arg Cys Ile Tyr Asn Gln Glu 
    50                  55                  60                  


Glu Ser Val Arg Phe Asp Ser Asp Val Gly Glu Tyr Arg Ala Val Thr 
65                  70                  75                  80  


Glu Leu Gly Arg Pro Asp Ala Glu Tyr Trp Asn Ser Gln Lys Asp Ile 
                85                  90                  95      


Leu Glu Asp Glu Arg Ala Ala Val Asp Thr Tyr Cys Arg His Asn Tyr 
            100                 105                 110         


Gly Val Gly Glu Ser Phe Thr Val Gln Arg Arg Val Glu Pro Lys Val 
        115                 120                 125             


Thr Val Tyr Pro Ser Lys Thr Gln Pro Leu Gln His His Asn Leu Leu 
    130                 135                 140                 


Val Cys Ser Val Ser Gly Phe Tyr Pro Gly Ser Ile Glu Val Arg Trp 
145                 150                 155                 160 


Phe Arg Asn Gly Gln Glu Glu Lys Ala Gly Val Val Ser Thr Gly Leu 
                165                 170                 175     


Ile Gln Asn Gly Asp Trp Thr Phe Gln Thr Leu Val Met Leu Glu Thr 
            180                 185                 190         


Val Pro Arg Ser Gly Glu Val Tyr Thr Cys Gln Val Glu His Pro Ser 
        195                 200                 205             


Val Thr Ser Pro Leu Thr Val Glu Trp Arg Ala Arg Ser Glu Ser Ala 
    210                 215                 220                 


Gln Ser Lys Met Leu Ser Gly Val Gly Gly Phe Val Leu Gly Leu Leu 
225                 230                 235                 240 


Phe Leu Gly Ala Gly Leu Phe Ile Tyr Phe Arg Asn Gln Lys Gly His 
                245                 250                 255     


Ser Gly Leu Gln Pro Thr Gly Phe Leu Ser 
            260                 265     


<210>  21
<211>  266
<212>  PRT
<213>  Homo sapiens

<400>  21

Met Val Cys Leu Arg Leu Pro Gly Gly Ser Cys Met Ala Val Leu Thr 
1               5                   10                  15      


Val Thr Leu Met Val Leu Ser Ser Pro Leu Ala Leu Ala Gly Asp Thr 
            20                  25                  30          


Arg Pro Arg Phe Leu Glu Tyr Ser Thr Ser Glu Cys His Phe Phe Asn 
        35                  40                  45              


Gly Thr Glu Arg Val Arg Tyr Leu Asp Arg Tyr Phe His Asn Gln Glu 
    50                  55                  60                  


Glu Asn Val Arg Phe Asp Ser Asp Val Gly Glu Phe Arg Ala Val Thr 
65                  70                  75                  80  


Glu Leu Gly Arg Pro Asp Ala Glu Tyr Trp Asn Ser Gln Lys Asp Leu 
                85                  90                  95      


Leu Glu Gln Lys Arg Gly Arg Val Asp Asn Tyr Cys Arg His Asn Tyr 
            100                 105                 110         


Gly Val Val Glu Ser Phe Thr Val Gln Arg Arg Val His Pro Lys Val 
        115                 120                 125             


Thr Val Tyr Pro Ser Lys Thr Gln Pro Leu Gln His His Asn Leu Leu 
    130                 135                 140                 


Val Cys Ser Val Ser Gly Phe Tyr Pro Gly Ser Ile Glu Val Arg Trp 
145                 150                 155                 160 


Phe Arg Asn Gly Gln Glu Glu Lys Thr Gly Val Val Ser Thr Gly Leu 
                165                 170                 175     


Ile His Asn Gly Asp Trp Thr Phe Gln Thr Leu Val Met Leu Glu Thr 
            180                 185                 190         


Val Pro Arg Ser Gly Glu Val Tyr Thr Cys Gln Val Glu His Pro Ser 
        195                 200                 205             


Val Thr Ser Pro Leu Thr Val Glu Trp Arg Ala Arg Ser Glu Ser Ala 
    210                 215                 220                 


Gln Ser Lys Met Leu Ser Gly Val Gly Gly Phe Val Leu Gly Leu Leu 
225                 230                 235                 240 


Phe Leu Gly Ala Gly Leu Phe Ile Tyr Phe Arg Asn Gln Lys Gly His 
                245                 250                 255     


Ser Gly Leu Gln Pro Arg Gly Phe Leu Ser 
            260                 265     


<210>  22
<211>  266
<212>  PRT
<213>  Homo sapiens

<400>  22

Met Val Cys Leu Arg Leu Pro Gly Gly Ser Cys Met Ala Val Leu Thr 
1               5                   10                  15      


Val Thr Leu Met Val Leu Ser Ser Pro Leu Ala Leu Ala Gly Asp Thr 
            20                  25                  30          


Arg Pro Arg Phe Leu Glu Tyr Ser Thr Ser Glu Cys His Phe Phe Asn 
        35                  40                  45              


Gly Thr Glu Arg Val Arg Phe Leu Glu Arg Tyr Phe His Asn Gln Glu 
    50                  55                  60                  


Glu Asn Val Arg Phe Asp Ser Asp Val Gly Glu Tyr Arg Ala Val Thr 
65                  70                  75                  80  


Glu Leu Gly Arg Pro Asp Ala Glu Tyr Trp Asn Ser Gln Lys Asp Leu 
                85                  90                  95      


Leu Glu Gln Lys Arg Gly Arg Val Asp Asn Tyr Cys Arg His Asn Tyr 
            100                 105                 110         


Gly Val Gly Glu Ser Phe Thr Val Gln Arg Arg Val His Pro Lys Val 
        115                 120                 125             


Thr Val Tyr Pro Ser Lys Thr Gln Pro Leu Gln His His Asn Leu Leu 
    130                 135                 140                 


Val Cys Ser Val Ser Gly Phe Tyr Pro Gly Ser Ile Glu Val Arg Trp 
145                 150                 155                 160 


Phe Arg Asn Gly Gln Glu Glu Lys Thr Gly Val Val Ser Thr Gly Leu 
                165                 170                 175     


Ile His Asn Gly Asp Trp Thr Phe Gln Thr Leu Val Met Leu Glu Thr 
            180                 185                 190         


Val Pro Arg Ser Gly Glu Val Tyr Thr Cys Gln Val Glu His Pro Ser 
        195                 200                 205             


Val Thr Ser Pro Leu Thr Val Glu Trp Arg Ala Arg Ser Glu Ser Ala 
    210                 215                 220                 


Gln Ser Lys Met Leu Ser Gly Val Gly Gly Phe Val Leu Gly Leu Leu 
225                 230                 235                 240 


Phe Leu Gly Ala Gly Leu Phe Ile Tyr Phe Arg Asn Gln Lys Gly His 
                245                 250                 255     


Ser Gly Leu Gln Pro Arg Gly Phe Leu Ser 
            260                 265     


<210>  23
<211>  266
<212>  PRT
<213>  Homo sapiens

<400>  23

Met Val Cys Leu Arg Leu Pro Gly Gly Ser Cys Met Ala Val Leu Thr 
1               5                   10                  15      


Val Thr Leu Met Val Leu Ser Ser Pro Leu Ala Leu Ala Gly Asp Thr 
            20                  25                  30          


Arg Pro Arg Phe Leu Glu Tyr Ser Thr Ser Glu Cys His Phe Phe Asn 
        35                  40                  45              


Gly Thr Glu Arg Val Arg Tyr Leu Asp Arg Tyr Phe His Asn Gln Glu 
    50                  55                  60                  


Glu Ser Val Arg Phe Asp Ser Asp Val Gly Glu Phe Arg Ala Val Thr 
65                  70                  75                  80  


Glu Leu Gly Arg Pro Asp Ala Glu Tyr Trp Asn Ser Gln Lys Asp Leu 
                85                  90                  95      


Leu Glu Gln Lys Arg Gly Arg Val Asp Asn Tyr Cys Arg His Asn Tyr 
            100                 105                 110         


Gly Val Val Glu Ser Phe Thr Val Gln Arg Arg Val His Pro Lys Val 
        115                 120                 125             


Thr Val Tyr Pro Ser Lys Thr Gln Pro Leu Gln His His Asn Leu Leu 
    130                 135                 140                 


Val Cys Ser Val Ser Gly Phe Tyr Pro Gly Ser Ile Glu Val Arg Trp 
145                 150                 155                 160 


Phe Arg Asn Gly Gln Glu Glu Lys Thr Gly Val Val Ser Thr Gly Leu 
                165                 170                 175     


Ile His Asn Gly Asp Trp Thr Phe Gln Thr Leu Val Met Leu Glu Thr 
            180                 185                 190         


Val Pro Arg Ser Gly Glu Val Tyr Thr Cys Gln Val Glu His Pro Ser 
        195                 200                 205             


Val Thr Ser Pro Leu Thr Val Glu Trp Arg Ala Arg Ser Glu Ser Ala 
    210                 215                 220                 


Gln Ser Lys Met Leu Ser Gly Val Gly Gly Phe Val Leu Gly Leu Leu 
225                 230                 235                 240 


Phe Leu Gly Ala Gly Leu Phe Ile Tyr Phe Arg Asn Gln Lys Gly His 
                245                 250                 255     


Ser Gly Leu Gln Pro Arg Gly Phe Leu Ser 
            260                 265     


<210>  24
<211>  266
<212>  PRT
<213>  Homo sapiens

<400>  24

Met Val Cys Leu Lys Phe Pro Gly Gly Ser Cys Met Ala Ala Leu Thr 
1               5                   10                  15      


Val Thr Leu Met Val Leu Ser Ser Pro Leu Ala Leu Ala Gly Asp Thr 
            20                  25                  30          


Arg Pro Arg Phe Leu Glu Gln Val Lys His Glu Cys His Phe Phe Asn 
        35                  40                  45              


Gly Thr Glu Arg Val Arg Phe Leu Asp Arg Tyr Phe Tyr His Gln Glu 
    50                  55                  60                  


Glu Tyr Val Arg Phe Asp Ser Asp Val Gly Glu Tyr Arg Ala Val Thr 
65                  70                  75                  80  


Glu Leu Gly Arg Pro Asp Ala Glu Tyr Trp Asn Ser Gln Lys Asp Leu 
                85                  90                  95      


Leu Glu Gln Lys Arg Ala Ala Val Asp Thr Tyr Cys Arg His Asn Tyr 
            100                 105                 110         


Gly Val Gly Glu Ser Phe Thr Val Gln Arg Arg Val Tyr Pro Glu Val 
        115                 120                 125             


Thr Val Tyr Pro Ala Lys Thr Gln Pro Leu Gln His His Asn Leu Leu 
    130                 135                 140                 


Val Cys Ser Val Asn Gly Phe Tyr Pro Gly Ser Ile Glu Val Arg Trp 
145                 150                 155                 160 


Phe Arg Asn Gly Gln Glu Glu Lys Thr Gly Val Val Ser Thr Gly Leu 
                165                 170                 175     


Ile Gln Asn Gly Asp Trp Thr Phe Gln Thr Leu Val Met Leu Glu Thr 
            180                 185                 190         


Val Pro Arg Ser Gly Glu Val Tyr Thr Cys Gln Val Glu His Pro Ser 
        195                 200                 205             


Leu Thr Ser Pro Leu Thr Val Glu Trp Arg Ala Arg Ser Glu Ser Ala 
    210                 215                 220                 


Gln Ser Lys Met Leu Ser Gly Val Gly Gly Phe Val Leu Gly Leu Leu 
225                 230                 235                 240 


Phe Leu Gly Ala Gly Leu Phe Ile Tyr Phe Arg Asn Gln Lys Gly His 
                245                 250                 255     


Ser Gly Leu Gln Pro Thr Gly Phe Leu Ser 
            260                 265     


<210>  25
<211>  266
<212>  PRT
<213>  Homo sapiens

<400>  25

Met Val Cys Leu Lys Phe Pro Gly Gly Ser Cys Met Ala Ala Leu Thr 
1               5                   10                  15      


Val Thr Leu Met Val Leu Ser Ser Pro Leu Ala Leu Ala Gly Asp Thr 
            20                  25                  30          


Arg Pro Arg Phe Leu Glu Gln Val Lys His Glu Cys His Phe Phe Asn 
        35                  40                  45              


Gly Thr Glu Arg Val Arg Phe Leu Asp Arg Tyr Phe Tyr His Gln Glu 
    50                  55                  60                  


Glu Tyr Val Arg Phe Asp Ser Asp Val Gly Glu Tyr Arg Ala Val Thr 
65                  70                  75                  80  


Glu Leu Gly Arg Pro Asp Ala Glu Tyr Trp Asn Ser Gln Lys Asp Ile 
                85                  90                  95      


Leu Glu Asp Glu Arg Ala Ala Val Asp Thr Tyr Cys Arg His Asn Tyr 
            100                 105                 110         


Gly Val Val Glu Ser Phe Thr Val Gln Arg Arg Val Tyr Pro Glu Val 
        115                 120                 125             


Thr Val Tyr Pro Ala Lys Thr Gln Pro Leu Gln His His Asn Leu Leu 
    130                 135                 140                 


Val Cys Ser Val Asn Gly Phe Tyr Pro Gly Ser Ile Glu Val Arg Trp 
145                 150                 155                 160 


Phe Arg Asn Gly Gln Glu Glu Lys Thr Gly Val Val Ser Thr Gly Leu 
                165                 170                 175     


Ile Gln Asn Gly Asp Trp Thr Phe Gln Thr Leu Val Met Leu Glu Thr 
            180                 185                 190         


Val Pro Arg Ser Gly Glu Val Tyr Thr Cys Gln Val Glu His Pro Ser 
        195                 200                 205             


Leu Thr Ser Pro Leu Thr Val Glu Trp Arg Ala Arg Ser Glu Ser Ala 
    210                 215                 220                 


Gln Ser Lys Met Leu Ser Gly Val Gly Gly Phe Val Leu Gly Leu Leu 
225                 230                 235                 240 


Phe Leu Gly Ala Gly Leu Phe Ile Tyr Phe Arg Asn Gln Lys Gly His 
                245                 250                 255     


Ser Gly Leu Gln Pro Thr Gly Phe Leu Ser 
            260                 265     


<210>  26
<211>  266
<212>  PRT
<213>  Homo sapiens

<400>  26

Met Val Cys Leu Lys Phe Pro Gly Gly Ser Cys Met Ala Ala Leu Thr 
1               5                   10                  15      


Val Thr Leu Met Val Leu Ser Ser Pro Leu Ala Leu Ala Gly Asp Thr 
            20                  25                  30          


Arg Pro Arg Phe Leu Glu Gln Val Lys His Glu Cys His Phe Phe Asn 
        35                  40                  45              


Gly Thr Glu Arg Val Arg Phe Leu Asp Arg Tyr Phe Tyr His Gln Glu 
    50                  55                  60                  


Glu Tyr Val Arg Phe Asp Ser Asp Val Gly Glu Tyr Arg Ala Val Thr 
65                  70                  75                  80  


Glu Leu Gly Arg Pro Asp Ala Glu Tyr Trp Asn Ser Gln Lys Asp Leu 
                85                  90                  95      


Leu Glu Gln Arg Arg Ala Glu Val Asp Thr Tyr Cys Arg His Asn Tyr 
            100                 105                 110         


Gly Val Val Glu Ser Phe Thr Val Gln Arg Arg Val Tyr Pro Glu Val 
        115                 120                 125             


Thr Val Tyr Pro Ala Lys Thr Gln Pro Leu Gln His His Asn Leu Leu 
    130                 135                 140                 


Val Cys Ser Val Asn Gly Phe Tyr Pro Gly Ser Ile Glu Val Arg Trp 
145                 150                 155                 160 


Phe Arg Asn Gly Gln Glu Glu Lys Thr Gly Val Val Ser Thr Gly Leu 
                165                 170                 175     


Ile Gln Asn Gly Asp Trp Thr Phe Gln Thr Leu Val Met Leu Glu Thr 
            180                 185                 190         


Val Pro Arg Ser Gly Glu Val Tyr Thr Cys Gln Val Glu His Pro Ser 
        195                 200                 205             


Leu Thr Ser Pro Leu Thr Val Glu Trp Arg Ala Arg Ser Glu Ser Ala 
    210                 215                 220                 


Gln Ser Lys Met Leu Ser Gly Val Gly Gly Phe Val Leu Gly Leu Leu 
225                 230                 235                 240 


Phe Leu Gly Ala Gly Leu Phe Ile Tyr Phe Arg Asn Gln Lys Gly His 
                245                 250                 255     


Ser Gly Leu Gln Pro Thr Gly Phe Leu Ser 
            260                 265     


<210>  27
<211>  266
<212>  PRT
<213>  Homo sapiens

<400>  27

Met Val Cys Leu Lys Phe Pro Gly Gly Ser Cys Met Ala Ala Leu Thr 
1               5                   10                  15      


Val Thr Leu Met Val Leu Ser Ser Pro Leu Ala Leu Ala Gly Asp Thr 
            20                  25                  30          


Arg Pro Arg Phe Leu Glu Gln Val Lys His Glu Cys His Phe Phe Asn 
        35                  40                  45              


Gly Thr Glu Arg Val Arg Phe Leu Asp Arg Tyr Phe Tyr His Gln Glu 
    50                  55                  60                  


Glu Tyr Val Arg Phe Asp Ser Asp Val Gly Glu Tyr Arg Ala Val Thr 
65                  70                  75                  80  


Glu Leu Gly Arg Pro Asp Ala Glu Tyr Trp Asn Ser Gln Lys Asp Leu 
                85                  90                  95      


Leu Glu Gln Arg Arg Ala Ala Val Asp Thr Tyr Cys Arg His Asn Tyr 
            100                 105                 110         


Gly Val Val Glu Ser Phe Thr Val Gln Arg Arg Val Tyr Pro Glu Val 
        115                 120                 125             


Thr Val Tyr Pro Ala Lys Thr Gln Pro Leu Gln His His Asn Leu Leu 
    130                 135                 140                 


Val Cys Ser Val Asn Gly Phe Tyr Pro Gly Ser Ile Glu Val Arg Trp 
145                 150                 155                 160 


Phe Arg Asn Gly Gln Glu Glu Lys Thr Gly Val Val Ser Thr Gly Leu 
                165                 170                 175     


Ile Gln Asn Gly Asp Trp Thr Phe Gln Thr Leu Val Met Leu Glu Thr 
            180                 185                 190         


Val Pro Arg Ser Gly Glu Val Tyr Thr Cys Gln Val Glu His Pro Ser 
        195                 200                 205             


Leu Thr Ser Pro Leu Thr Val Glu Trp Arg Ala Arg Ser Glu Ser Ala 
    210                 215                 220                 


Gln Ser Lys Met Leu Ser Gly Val Gly Gly Phe Val Leu Gly Leu Leu 
225                 230                 235                 240 


Phe Leu Gly Ala Gly Leu Phe Ile Tyr Phe Arg Asn Gln Lys Gly His 
                245                 250                 255     


Ser Gly Leu Gln Pro Thr Gly Phe Leu Ser 
            260                 265     


<210>  28
<211>  266
<212>  PRT
<213>  Homo sapiens

<400>  28

Met Val Cys Leu Lys Phe Pro Gly Gly Ser Cys Met Ala Ala Leu Thr 
1               5                   10                  15      


Val Thr Leu Met Val Leu Ser Ser Pro Leu Ala Leu Ala Gly Asp Thr 
            20                  25                  30          


Arg Pro Arg Phe Leu Glu Gln Val Lys His Glu Cys His Phe Phe Asn 
        35                  40                  45              


Gly Thr Glu Arg Val Arg Phe Leu Asp Arg Tyr Phe Tyr His Gln Glu 
    50                  55                  60                  


Glu Tyr Val Arg Phe Asp Ser Asp Val Gly Glu Tyr Arg Ala Val Thr 
65                  70                  75                  80  


Glu Leu Gly Arg Pro Ser Ala Glu Tyr Trp Asn Ser Gln Lys Asp Leu 
                85                  90                  95      


Leu Glu Gln Arg Arg Ala Ala Val Asp Thr Tyr Cys Arg His Asn Tyr 
            100                 105                 110         


Gly Val Gly Glu Ser Phe Thr Val Gln Arg Arg Val Tyr Pro Glu Val 
        115                 120                 125             


Thr Val Tyr Pro Ala Lys Thr Gln Pro Leu Gln His His Asn Leu Leu 
    130                 135                 140                 


Val Cys Ser Val Asn Gly Phe Tyr Pro Gly Ser Ile Glu Val Arg Trp 
145                 150                 155                 160 


Phe Arg Asn Gly Gln Glu Glu Lys Thr Gly Val Val Ser Thr Gly Leu 
                165                 170                 175     


Ile Gln Asn Gly Asp Trp Thr Phe Gln Thr Leu Val Met Leu Glu Thr 
            180                 185                 190         


Val Pro Arg Ser Gly Glu Val Tyr Thr Cys Gln Val Glu His Pro Ser 
        195                 200                 205             


Leu Thr Ser Pro Leu Thr Val Glu Trp Arg Ala Arg Ser Glu Ser Ala 
    210                 215                 220                 


Gln Ser Lys Met Leu Ser Gly Val Gly Gly Phe Val Leu Gly Leu Leu 
225                 230                 235                 240 


Phe Leu Gly Ala Gly Leu Phe Ile Tyr Phe Arg Asn Gln Lys Gly His 
                245                 250                 255     


Ser Gly Leu Gln Pro Thr Gly Phe Leu Ser 
            260                 265     


<210>  29
<211>  266
<212>  PRT
<213>  Homo sapiens

<400>  29

Met Val Cys Leu Lys Phe Pro Gly Gly Ser Cys Met Ala Ala Leu Thr 
1               5                   10                  15      


Val Thr Leu Met Val Leu Ser Ser Pro Leu Ala Leu Ala Gly Asp Thr 
            20                  25                  30          


Arg Pro Arg Phe Leu Glu Gln Val Lys His Glu Cys His Phe Phe Asn 
        35                  40                  45              


Gly Thr Glu Arg Val Arg Phe Leu Asp Arg Tyr Phe Tyr His Gln Glu 
    50                  55                  60                  


Glu Ser Val Arg Phe Asp Ser Asp Val Gly Glu Tyr Arg Ala Val Thr 
65                  70                  75                  80  


Glu Leu Gly Arg Pro Asp Ala Glu Tyr Trp Asn Ser Gln Lys Asp Leu 
                85                  90                  95      


Leu Glu Gln Arg Arg Ala Glu Val Asp Thr Tyr Cys Arg His Asn Tyr 
            100                 105                 110         


Gly Val Val Glu Ser Phe Thr Val Gln Arg Arg Val Tyr Pro Glu Val 
        115                 120                 125             


Thr Val Tyr Pro Ala Lys Thr Gln Pro Leu Gln His His Asn Leu Leu 
    130                 135                 140                 


Val Cys Ser Val Asn Gly Phe Tyr Pro Gly Ser Ile Glu Val Arg Trp 
145                 150                 155                 160 


Phe Arg Asn Gly Gln Glu Glu Lys Thr Gly Val Val Ser Thr Gly Leu 
                165                 170                 175     


Ile Gln Asn Gly Asp Trp Thr Phe Gln Thr Leu Val Met Leu Glu Thr 
            180                 185                 190         


Val Pro Arg Ser Gly Glu Val Tyr Thr Cys Gln Val Glu His Pro Ser 
        195                 200                 205             


Leu Thr Ser Pro Leu Thr Val Glu Trp Arg Ala Arg Ser Glu Ser Ala 
    210                 215                 220                 


Gln Ser Lys Met Leu Ser Gly Val Gly Gly Phe Val Leu Gly Leu Leu 
225                 230                 235                 240 


Phe Leu Gly Ala Gly Leu Phe Ile Tyr Phe Arg Asn Gln Lys Gly His 
                245                 250                 255     


Ser Gly Leu Gln Pro Thr Gly Phe Leu Ser 
            260                 265     


<210>  30
<211>  266
<212>  PRT
<213>  Homo sapiens

<400>  30

Met Val Cys Leu Lys Phe Pro Gly Gly Ser Cys Met Ala Ala Leu Thr 
1               5                   10                  15      


Val Thr Leu Met Val Leu Ser Ser Pro Leu Ala Leu Ala Gly Asp Thr 
            20                  25                  30          


Arg Pro Arg Phe Leu Glu Gln Val Lys His Glu Cys His Phe Phe Asn 
        35                  40                  45              


Gly Thr Glu Arg Val Arg Phe Leu Asp Arg Tyr Phe Tyr His Gln Glu 
    50                  55                  60                  


Glu Tyr Val Arg Phe Asp Ser Asp Val Gly Glu Tyr Arg Ala Val Thr 
65                  70                  75                  80  


Glu Leu Gly Arg Pro Asp Ala Glu Tyr Trp Asn Ser Gln Lys Asp Leu 
                85                  90                  95      


Leu Glu Gln Arg Arg Ala Ala Val Asp Thr Tyr Cys Arg His Asn Tyr 
            100                 105                 110         


Gly Val Gly Glu Ser Phe Thr Val Gln Arg Arg Val Tyr Pro Glu Val 
        115                 120                 125             


Thr Val Tyr Pro Ala Lys Thr Gln Pro Leu Gln His His Asn Leu Leu 
    130                 135                 140                 


Val Cys Ser Val Asn Gly Phe Tyr Pro Gly Ser Ile Glu Val Arg Trp 
145                 150                 155                 160 


Phe Arg Asn Gly Gln Glu Glu Lys Thr Gly Val Val Ser Thr Gly Leu 
                165                 170                 175     


Ile Gln Asn Gly Asp Trp Thr Phe Gln Thr Leu Val Met Leu Glu Thr 
            180                 185                 190         


Val Pro Arg Ser Gly Glu Val Tyr Thr Cys Gln Val Glu His Pro Ser 
        195                 200                 205             


Leu Thr Ser Pro Leu Thr Val Glu Trp Arg Ala Arg Ser Glu Ser Ala 
    210                 215                 220                 


Gln Ser Lys Met Leu Ser Gly Val Gly Gly Phe Val Leu Gly Leu Leu 
225                 230                 235                 240 


Phe Leu Gly Ala Gly Leu Phe Ile Tyr Phe Arg Asn Gln Lys Gly His 
                245                 250                 255     


Ser Gly Leu Gln Pro Thr Gly Phe Leu Ser 
            260                 265     


<210>  31
<211>  266
<212>  PRT
<213>  Homo sapiens

<400>  31

Met Val Cys Leu Lys Leu Pro Gly Gly Ser Cys Met Ala Ala Leu Thr 
1               5                   10                  15      


Val Thr Leu Met Val Leu Ser Ser Pro Leu Ala Leu Ala Gly Asp Thr 
            20                  25                  30          


Gln Pro Arg Phe Leu Trp Gln Gly Lys Tyr Lys Cys His Phe Phe Asn 
        35                  40                  45              


Gly Thr Glu Arg Val Gln Phe Leu Glu Arg Leu Phe Tyr Asn Gln Glu 
    50                  55                  60                  


Glu Phe Val Arg Phe Asp Ser Asp Val Gly Glu Tyr Arg Ala Val Thr 
65                  70                  75                  80  


Glu Leu Gly Arg Pro Val Ala Glu Ser Trp Asn Ser Gln Lys Asp Ile 
                85                  90                  95      


Leu Glu Asp Arg Arg Gly Gln Val Asp Thr Val Cys Arg His Asn Tyr 
            100                 105                 110         


Gly Val Gly Glu Ser Phe Thr Val Gln Arg Arg Val His Pro Glu Val 
        115                 120                 125             


Thr Val Tyr Pro Ala Lys Thr Gln Pro Leu Gln His His Asn Leu Leu 
    130                 135                 140                 


Val Cys Ser Val Ser Gly Phe Tyr Pro Gly Ser Ile Glu Val Arg Trp 
145                 150                 155                 160 


Phe Arg Asn Gly Gln Glu Glu Lys Ala Gly Val Val Ser Thr Gly Leu 
                165                 170                 175     


Ile Gln Asn Gly Asp Trp Thr Phe Gln Thr Leu Val Met Leu Glu Thr 
            180                 185                 190         


Val Pro Arg Ser Gly Glu Val Tyr Thr Cys Gln Val Glu His Pro Ser 
        195                 200                 205             


Val Met Ser Pro Leu Thr Val Glu Trp Arg Ala Arg Ser Glu Ser Ala 
    210                 215                 220                 


Gln Ser Lys Met Leu Ser Gly Val Gly Gly Phe Val Leu Gly Leu Leu 
225                 230                 235                 240 


Phe Leu Gly Ala Gly Leu Phe Ile Tyr Phe Arg Asn Gln Lys Gly His 
                245                 250                 255     


Ser Gly Leu Gln Pro Thr Gly Phe Leu Ser 
            260                 265     


<210>  32
<211>  266
<212>  PRT
<213>  Homo sapiens

<400>  32

Met Val Cys Leu Arg Leu Pro Gly Gly Ser Cys Met Ala Val Leu Thr 
1               5                   10                  15      


Val Thr Leu Met Val Leu Ser Ser Pro Leu Ala Leu Ala Gly Asp Thr 
            20                  25                  30          


Arg Pro Arg Phe Leu Glu Tyr Ser Thr Gly Glu Cys Tyr Phe Phe Asn 
        35                  40                  45              


Gly Thr Glu Arg Val Arg Phe Leu Asp Arg Tyr Phe Tyr Asn Gln Glu 
    50                  55                  60                  


Glu Tyr Val Arg Phe Asp Ser Asp Val Gly Glu Tyr Arg Ala Val Thr 
65                  70                  75                  80  


Glu Leu Gly Arg Pro Ser Ala Glu Tyr Trp Asn Ser Gln Lys Asp Phe 
                85                  90                  95      


Leu Glu Asp Arg Arg Ala Leu Val Asp Thr Tyr Cys Arg His Asn Tyr 
            100                 105                 110         


Gly Val Gly Glu Ser Phe Thr Val Gln Arg Arg Val His Pro Lys Val 
        115                 120                 125             


Thr Val Tyr Pro Ser Lys Thr Gln Pro Leu Gln His His Asn Leu Leu 
    130                 135                 140                 


Val Cys Ser Val Ser Gly Phe Tyr Pro Gly Ser Ile Glu Val Arg Trp 
145                 150                 155                 160 


Phe Arg Asn Gly Gln Glu Glu Lys Thr Gly Val Val Ser Thr Gly Leu 
                165                 170                 175     


Ile His Asn Gly Asp Trp Thr Phe Gln Thr Leu Val Met Leu Glu Thr 
            180                 185                 190         


Val Pro Arg Ser Gly Glu Val Tyr Thr Cys Gln Val Glu His Pro Ser 
        195                 200                 205             


Val Thr Ser Pro Leu Thr Val Glu Trp Ser Ala Arg Ser Glu Ser Ala 
    210                 215                 220                 


Gln Ser Lys Met Leu Ser Gly Val Gly Gly Phe Val Leu Gly Leu Leu 
225                 230                 235                 240 


Phe Leu Gly Ala Gly Leu Phe Ile Tyr Phe Arg Asn Gln Lys Gly His 
                245                 250                 255     


Ser Gly Leu Gln Pro Thr Gly Phe Leu Ser 
            260                 265     


<210>  33
<211>  266
<212>  PRT
<213>  Homo sapiens

<400>  33

Met Val Cys Leu Arg Leu Pro Gly Gly Ser Cys Met Ala Val Leu Thr 
1               5                   10                  15      


Val Thr Leu Met Val Leu Ser Ser Pro Leu Ala Leu Ala Gly Asp Thr 
            20                  25                  30          


Arg Pro Arg Phe Leu Glu Tyr Ser Thr Gly Glu Cys Tyr Phe Phe Asn 
        35                  40                  45              


Gly Thr Glu Arg Val Arg Phe Leu Asp Arg Tyr Phe Tyr Asn Gln Glu 
    50                  55                  60                  


Glu Tyr Val Arg Phe Asp Ser Asp Val Gly Glu Tyr Arg Ala Val Thr 
65                  70                  75                  80  


Glu Leu Gly Arg Pro Asp Ala Glu Tyr Trp Asn Ser Gln Lys Asp Phe 
                85                  90                  95      


Leu Glu Asp Arg Arg Ala Leu Val Asp Thr Tyr Cys Arg His Asn Tyr 
            100                 105                 110         


Gly Val Gly Glu Ser Phe Thr Val Gln Arg Arg Val His Pro Lys Val 
        115                 120                 125             


Thr Val Tyr Pro Ser Lys Thr Gln Pro Leu Gln His His Asn Leu Leu 
    130                 135                 140                 


Val Cys Ser Val Ser Gly Phe Tyr Pro Gly Ser Ile Glu Val Arg Trp 
145                 150                 155                 160 


Phe Arg Asn Gly Gln Glu Glu Lys Thr Gly Val Val Ser Thr Gly Leu 
                165                 170                 175     


Ile His Asn Gly Asp Trp Thr Phe Gln Thr Leu Val Met Leu Glu Thr 
            180                 185                 190         


Val Pro Arg Ser Gly Glu Val Tyr Thr Cys Gln Val Glu His Pro Ser 
        195                 200                 205             


Val Thr Ser Pro Leu Thr Val Glu Trp Ser Ala Arg Ser Glu Ser Ala 
    210                 215                 220                 


Gln Ser Lys Met Leu Ser Gly Val Gly Gly Phe Val Leu Gly Leu Leu 
225                 230                 235                 240 


Phe Leu Gly Ala Gly Leu Phe Ile Tyr Phe Arg Asn Gln Lys Gly His 
                245                 250                 255     


Ser Gly Leu Gln Pro Thr Gly Phe Leu Ser 
            260                 265     


<210>  34
<211>  266
<212>  PRT
<213>  Homo sapiens

<400>  34

Met Val Cys Leu Arg Leu Pro Gly Gly Ser Cys Met Ala Val Leu Thr 
1               5                   10                  15      


Val Thr Leu Met Val Leu Ser Ser Pro Leu Ala Leu Ala Gly Asp Thr 
            20                  25                  30          


Arg Pro Arg Phe Leu Glu Tyr Ser Thr Gly Glu Cys Tyr Phe Phe Asn 
        35                  40                  45              


Gly Thr Glu Arg Val Arg Phe Leu Asp Arg Tyr Phe Tyr Asn Gln Glu 
    50                  55                  60                  


Glu Tyr Val Arg Phe Asp Ser Asp Val Gly Glu Tyr Arg Ala Val Thr 
65                  70                  75                  80  


Glu Leu Gly Arg Pro Ser Ala Glu Tyr Trp Asn Ser Gln Lys Asp Ile 
                85                  90                  95      


Leu Glu Asp Arg Arg Ala Leu Val Asp Thr Tyr Cys Arg His Asn Tyr 
            100                 105                 110         


Gly Val Gly Glu Ser Phe Thr Val Gln Arg Arg Val His Pro Lys Val 
        115                 120                 125             


Thr Val Tyr Pro Ser Lys Thr Gln Pro Leu Gln His His Asn Leu Leu 
    130                 135                 140                 


Val Cys Ser Val Ser Gly Phe Tyr Pro Gly Ser Ile Glu Val Arg Trp 
145                 150                 155                 160 


Phe Arg Asn Gly Gln Glu Glu Lys Thr Gly Val Val Ser Thr Gly Leu 
                165                 170                 175     


Ile His Asn Gly Asp Trp Thr Phe Gln Thr Leu Val Met Leu Glu Thr 
            180                 185                 190         


Val Pro Arg Ser Gly Glu Val Tyr Thr Cys Gln Val Glu His Pro Ser 
        195                 200                 205             


Val Thr Ser Pro Leu Thr Val Glu Trp Ser Ala Arg Ser Glu Ser Ala 
    210                 215                 220                 


Gln Ser Lys Met Leu Ser Gly Val Gly Gly Phe Val Leu Gly Leu Leu 
225                 230                 235                 240 


Phe Leu Gly Ala Gly Leu Phe Ile Tyr Phe Arg Asn Gln Lys Gly His 
                245                 250                 255     


Ser Gly Leu Gln Pro Thr Gly Phe Leu Ser 
            260                 265     


<210>  35
<211>  266
<212>  PRT
<213>  Homo sapiens

<400>  35

Met Val Cys Leu Lys Leu Pro Gly Gly Ser Cys Met Ala Ala Leu Thr 
1               5                   10                  15      


Val Thr Leu Met Val Leu Ser Ser Pro Leu Ala Leu Ala Gly Asp Thr 
            20                  25                  30          


Gln Pro Arg Phe Leu Lys Gln Asp Lys Phe Glu Cys His Phe Phe Asn 
        35                  40                  45              


Gly Thr Glu Arg Val Arg Tyr Leu His Arg Gly Ile Tyr Asn Gln Glu 
    50                  55                  60                  


Glu Asn Val Arg Phe Asp Ser Asp Val Gly Glu Tyr Arg Ala Val Thr 
65                  70                  75                  80  


Glu Leu Gly Arg Pro Val Ala Glu Ser Trp Asn Ser Gln Lys Asp Phe 
                85                  90                  95      


Leu Glu Arg Arg Arg Ala Glu Val Asp Thr Val Cys Arg His Asn Tyr 
            100                 105                 110         


Gly Val Gly Glu Ser Phe Thr Val Gln Arg Arg Val His Pro Glu Val 
        115                 120                 125             


Thr Val Tyr Pro Ala Lys Thr Gln Pro Leu Gln His His Asn Leu Leu 
    130                 135                 140                 


Val Cys Ser Val Ser Gly Phe Tyr Pro Gly Ser Ile Glu Val Arg Trp 
145                 150                 155                 160 


Phe Arg Asn Gly Gln Glu Glu Lys Ala Gly Val Val Ser Thr Gly Leu 
                165                 170                 175     


Ile Gln Asn Gly Asp Trp Thr Phe Gln Thr Leu Val Met Leu Glu Thr 
            180                 185                 190         


Val Pro Arg Ser Gly Glu Val Tyr Thr Cys Gln Val Glu His Pro Ser 
        195                 200                 205             


Val Met Ser Pro Leu Thr Val Glu Trp Arg Ala Arg Ser Glu Ser Ala 
    210                 215                 220                 


Gln Ser Lys Met Leu Ser Gly Val Gly Gly Phe Val Leu Gly Leu Leu 
225                 230                 235                 240 


Phe Leu Gly Ala Gly Leu Phe Ile Tyr Phe Arg Asn Gln Lys Gly His 
                245                 250                 255     


Ser Gly Leu Gln Pro Thr Gly Phe Leu Ser 
            260                 265     


<210>  36
<211>  266
<212>  PRT
<213>  Homo sapiens

<400>  36

Met Val Cys Leu Arg Leu Pro Gly Gly Ser Cys Met Ala Val Leu Thr 
1               5                   10                  15      


Val Thr Leu Met Val Leu Ser Ser Pro Leu Ala Leu Ala Gly Asp Thr 
            20                  25                  30          


Arg Pro Arg Phe Leu Glu Glu Val Lys Phe Glu Cys His Phe Phe Asn 
        35                  40                  45              


Gly Thr Glu Arg Val Arg Leu Leu Glu Arg Arg Val His Asn Gln Glu 
    50                  55                  60                  


Glu Tyr Ala Arg Tyr Asp Ser Asp Val Gly Glu Tyr Arg Ala Val Thr 
65                  70                  75                  80  


Glu Leu Gly Arg Pro Asp Ala Glu Tyr Trp Asn Ser Gln Lys Asp Leu 
                85                  90                  95      


Leu Glu Arg Arg Arg Ala Ala Val Asp Thr Tyr Cys Arg His Asn Tyr 
            100                 105                 110         


Gly Val Gly Glu Ser Phe Thr Val Gln Arg Arg Val Gln Pro Lys Val 
        115                 120                 125             


Thr Val Tyr Pro Ser Lys Thr Gln Pro Leu Gln His His Asn Leu Leu 
    130                 135                 140                 


Val Cys Ser Val Asn Gly Phe Tyr Pro Gly Ser Ile Glu Val Arg Trp 
145                 150                 155                 160 


Phe Arg Asn Gly Gln Glu Glu Lys Thr Gly Val Val Ser Thr Gly Leu 
                165                 170                 175     


Ile Gln Asn Gly Asp Trp Thr Phe Gln Thr Leu Val Met Leu Glu Thr 
            180                 185                 190         


Val Pro Gln Ser Gly Glu Val Tyr Thr Cys Gln Val Glu His Pro Ser 
        195                 200                 205             


Val Met Ser Pro Leu Thr Val Glu Trp Arg Ala Arg Ser Glu Ser Ala 
    210                 215                 220                 


Gln Ser Lys Met Leu Ser Gly Val Gly Gly Phe Val Leu Gly Leu Leu 
225                 230                 235                 240 


Phe Leu Gly Ala Gly Leu Phe Ile Tyr Phe Arg Asn Gln Lys Gly His 
                245                 250                 255     


Ser Gly Leu Pro Pro Thr Gly Phe Leu Ser 
            260                 265     


<210>  37
<211>  266
<212>  PRT
<213>  Homo sapiens

<400>  37

Met Val Cys Leu Arg Leu Pro Gly Gly Ser Cys Met Ala Val Leu Thr 
1               5                   10                  15      


Val Thr Leu Met Val Leu Ser Ser Pro Leu Ala Leu Ala Gly Asp Thr 
            20                  25                  30          


Arg Pro Arg Phe Leu Glu Tyr Ser Thr Ser Glu Cys His Phe Phe Asn 
        35                  40                  45              


Gly Thr Glu Arg Val Arg Phe Leu Asp Arg Tyr Phe Tyr Asn Gln Glu 
    50                  55                  60                  


Glu Tyr Val Arg Phe Asp Ser Asp Val Gly Glu Phe Arg Ala Val Thr 
65                  70                  75                  80  


Glu Leu Gly Arg Pro Asp Glu Glu Tyr Trp Asn Ser Gln Lys Asp Phe 
                85                  90                  95      


Leu Glu Asp Arg Arg Ala Ala Val Asp Thr Tyr Cys Arg His Asn Tyr 
            100                 105                 110         


Gly Val Gly Glu Ser Phe Thr Val Gln Arg Arg Val His Pro Lys Val 
        115                 120                 125             


Thr Val Tyr Pro Ser Lys Thr Gln Pro Leu Gln His His Asn Leu Leu 
    130                 135                 140                 


Val Cys Ser Val Ser Gly Phe Tyr Pro Gly Ser Ile Glu Val Arg Trp 
145                 150                 155                 160 


Phe Arg Asn Gly Gln Glu Glu Lys Thr Gly Val Val Ser Thr Gly Leu 
                165                 170                 175     


Ile His Asn Gly Asp Trp Thr Phe Gln Thr Leu Val Met Leu Glu Thr 
            180                 185                 190         


Val Pro Arg Ser Gly Glu Val Tyr Thr Cys Gln Val Glu His Pro Ser 
        195                 200                 205             


Val Thr Ser Pro Leu Thr Val Glu Trp Arg Ala Arg Ser Glu Ser Ala 
    210                 215                 220                 


Gln Ser Lys Met Leu Ser Gly Val Gly Gly Phe Val Leu Gly Leu Leu 
225                 230                 235                 240 


Phe Leu Gly Ala Gly Leu Phe Ile Tyr Phe Arg Asn Gln Lys Gly His 
                245                 250                 255     


Ser Gly Leu Gln Pro Arg Gly Phe Leu Ser 
            260                 265     


<210>  38
<211>  266
<212>  PRT
<213>  Homo sapiens

<400>  38

Met Val Cys Leu Arg Leu Pro Gly Gly Ser Cys Met Ala Val Leu Thr 
1               5                   10                  15      


Val Thr Leu Met Val Leu Ser Ser Pro Leu Ala Leu Ala Gly Asp Thr 
            20                  25                  30          


Arg Pro Arg Phe Leu Glu Tyr Ser Thr Ser Glu Cys His Phe Phe Asn 
        35                  40                  45              


Gly Thr Glu Arg Val Arg Phe Leu Asp Arg Tyr Phe Tyr Asn Gln Glu 
    50                  55                  60                  


Glu Tyr Val Arg Phe Asp Ser Asp Val Gly Glu Phe Arg Ala Val Thr 
65                  70                  75                  80  


Glu Leu Gly Arg Pro Asp Glu Glu Tyr Trp Asn Ser Gln Lys Asp Phe 
                85                  90                  95      


Leu Glu Asp Glu Arg Ala Ala Val Asp Thr Tyr Cys Arg His Asn Tyr 
            100                 105                 110         


Gly Val Val Glu Ser Phe Thr Val Gln Arg Arg Val His Pro Lys Val 
        115                 120                 125             


Thr Val Tyr Pro Ser Lys Thr Gln Pro Leu Gln His His Asn Leu Leu 
    130                 135                 140                 


Val Cys Ser Val Ser Gly Phe Tyr Pro Gly Ser Ile Glu Val Arg Trp 
145                 150                 155                 160 


Phe Arg Asn Gly Gln Glu Glu Lys Thr Gly Val Val Ser Thr Gly Leu 
                165                 170                 175     


Ile His Asn Gly Asp Trp Thr Phe Gln Thr Leu Val Met Leu Glu Thr 
            180                 185                 190         


Val Pro Arg Ser Gly Glu Val Tyr Thr Cys Gln Val Glu His Pro Ser 
        195                 200                 205             


Val Thr Ser Pro Leu Thr Val Glu Trp Arg Ala Arg Ser Glu Ser Ala 
    210                 215                 220                 


Gln Ser Lys Met Leu Ser Gly Val Gly Gly Phe Val Leu Gly Leu Leu 
225                 230                 235                 240 


Phe Leu Gly Ala Gly Leu Phe Ile Tyr Phe Arg Asn Gln Lys Gly His 
                245                 250                 255     


Ser Gly Leu Gln Pro Arg Gly Phe Leu Ser 
            260                 265     


<210>  39
<211>  266
<212>  PRT
<213>  Homo sapiens

<400>  39

Met Val Cys Leu Arg Leu Pro Gly Gly Ser Cys Met Ala Val Leu Thr 
1               5                   10                  15      


Val Thr Leu Met Val Leu Ser Ser Pro Leu Ala Leu Ala Gly Asp Thr 
            20                  25                  30          


Arg Pro Arg Phe Leu Glu Tyr Ser Thr Ser Glu Cys His Phe Phe Asn 
        35                  40                  45              


Gly Thr Glu Arg Val Arg Phe Leu Asp Arg Tyr Phe Tyr Asn Gln Glu 
    50                  55                  60                  


Glu Tyr Val Arg Phe Asp Ser Asp Val Gly Glu Phe Arg Ala Val Thr 
65                  70                  75                  80  


Glu Leu Gly Arg Pro Asp Glu Glu Tyr Trp Asn Ser Gln Lys Asp Phe 
                85                  90                  95      


Leu Glu Asp Arg Arg Ala Ala Val Asp Thr Tyr Cys Arg His Asn Tyr 
            100                 105                 110         


Gly Val Val Glu Ser Phe Thr Val Gln Arg Arg Val His Pro Lys Val 
        115                 120                 125             


Thr Val Tyr Pro Ser Lys Thr Gln Pro Leu Gln His His Asn Leu Leu 
    130                 135                 140                 


Val Cys Ser Val Ser Gly Phe Tyr Pro Gly Ser Ile Glu Val Arg Trp 
145                 150                 155                 160 


Phe Arg Asn Gly Gln Glu Glu Lys Thr Gly Val Val Ser Thr Gly Leu 
                165                 170                 175     


Ile His Asn Gly Asp Trp Thr Phe Gln Thr Leu Val Met Leu Glu Thr 
            180                 185                 190         


Val Pro Arg Ser Gly Glu Val Tyr Thr Cys Gln Val Glu His Pro Ser 
        195                 200                 205             


Val Thr Ser Pro Leu Thr Val Glu Trp Arg Ala Arg Ser Glu Ser Ala 
    210                 215                 220                 


Gln Ser Lys Met Leu Ser Gly Val Gly Gly Phe Val Leu Gly Leu Leu 
225                 230                 235                 240 


Phe Leu Gly Ala Gly Leu Phe Ile Tyr Phe Arg Asn Gln Lys Gly His 
                245                 250                 255     


Ser Gly Leu Gln Pro Arg Gly Phe Leu Ser 
            260                 265     


<210>  40
<211>  266
<212>  PRT
<213>  Homo sapiens

<400>  40

Met Val Cys Leu Arg Leu Pro Gly Gly Ser Cys Met Ala Val Leu Thr 
1               5                   10                  15      


Val Thr Leu Met Val Leu Ser Ser Pro Leu Ala Leu Ala Gly Asp Thr 
            20                  25                  30          


Arg Pro Arg Phe Leu Glu Tyr Ser Thr Gly Glu Cys Tyr Phe Phe Asn 
        35                  40                  45              


Gly Thr Glu Arg Val Arg Leu Leu Glu Arg His Phe His Asn Gln Glu 
    50                  55                  60                  


Glu Leu Leu Arg Phe Asp Ser Asp Val Gly Glu Phe Arg Ala Val Thr 
65                  70                  75                  80  


Glu Leu Gly Arg Pro Val Ala Glu Ser Trp Asn Ser Gln Lys Asp Ile 
                85                  90                  95      


Leu Glu Asp Arg Arg Ala Ala Val Asp Thr Tyr Cys Arg His Asn Tyr 
            100                 105                 110         


Gly Ala Val Glu Ser Phe Thr Val Gln Arg Arg Val His Pro Lys Val 
        115                 120                 125             


Thr Val Tyr Pro Ser Lys Thr Gln Pro Leu Gln His His Asn Leu Leu 
    130                 135                 140                 


Val Cys Ser Val Ser Gly Phe Tyr Pro Gly Ser Ile Glu Val Arg Trp 
145                 150                 155                 160 


Phe Arg Asn Gly Gln Glu Glu Lys Thr Gly Val Val Ser Thr Gly Leu 
                165                 170                 175     


Ile His Asn Gly Asp Trp Thr Phe Gln Thr Leu Val Met Leu Glu Thr 
            180                 185                 190         


Val Pro Arg Ser Gly Glu Val Tyr Thr Cys Gln Val Glu His Pro Ser 
        195                 200                 205             


Val Thr Ser Pro Leu Thr Val Glu Trp Arg Ala Arg Ser Glu Ser Ala 
    210                 215                 220                 


Gln Ser Lys Met Leu Ser Gly Val Gly Gly Phe Val Leu Gly Leu Leu 
225                 230                 235                 240 


Phe Leu Gly Ala Gly Leu Phe Ile Tyr Phe Arg Asn Gln Lys Gly His 
                245                 250                 255     


Ser Gly Leu Gln Pro Arg Gly Phe Leu Ser 
            260                 265     


<210>  41
<211>  266
<212>  PRT
<213>  Homo sapiens

<400>  41

Met Val Cys Leu Arg Leu Pro Gly Gly Ser Cys Met Ala Val Leu Thr 
1               5                   10                  15      


Val Thr Leu Met Val Leu Ser Ser Pro Leu Ala Leu Ala Gly Asp Thr 
            20                  25                  30          


Arg Pro Arg Phe Leu Glu Tyr Ser Thr Ser Glu Cys His Phe Phe Asn 
        35                  40                  45              


Gly Thr Glu Arg Val Arg Phe Leu Asp Arg Tyr Phe His Asn Gln Glu 
    50                  55                  60                  


Glu Asn Val Arg Phe Asp Ser Asp Val Gly Glu Phe Arg Ala Val Thr 
65                  70                  75                  80  


Glu Leu Gly Arg Pro Asp Ala Glu Tyr Trp Asn Ser Gln Lys Asp Ile 
                85                  90                  95      


Leu Glu Asp Glu Arg Ala Ala Val Asp Thr Tyr Cys Arg His Asn Tyr 
            100                 105                 110         


Gly Val Val Glu Ser Phe Thr Val Gln Arg Arg Val His Pro Lys Val 
        115                 120                 125             


Thr Val Tyr Pro Ser Lys Thr Gln Pro Leu Gln His His Asn Leu Leu 
    130                 135                 140                 


Val Cys Ser Val Ser Gly Phe Tyr Pro Gly Ser Ile Glu Val Arg Trp 
145                 150                 155                 160 


Phe Arg Asn Gly Gln Glu Glu Lys Thr Gly Val Val Ser Thr Gly Leu 
                165                 170                 175     


Ile His Asn Gly Asp Trp Thr Phe Gln Thr Leu Val Met Leu Glu Thr 
            180                 185                 190         


Val Pro Arg Ser Gly Glu Val Tyr Thr Cys Gln Val Glu His Pro Ser 
        195                 200                 205             


Val Thr Ser Pro Leu Thr Val Glu Trp Arg Ala Arg Ser Glu Ser Ala 
    210                 215                 220                 


Gln Ser Lys Met Leu Ser Gly Val Gly Gly Phe Val Leu Gly Leu Leu 
225                 230                 235                 240 


Phe Leu Gly Ala Gly Leu Phe Ile Tyr Phe Arg Asn Gln Lys Gly His 
                245                 250                 255     


Ser Gly Leu Gln Pro Arg Gly Phe Leu Ser 
            260                 265     


<210>  42
<211>  266
<212>  PRT
<213>  Homo sapiens

<400>  42

Met Val Cys Leu Arg Leu Pro Gly Gly Ser Cys Met Ala Val Leu Thr 
1               5                   10                  15      


Val Thr Leu Met Val Leu Ser Ser Pro Leu Ala Leu Ala Gly Asp Thr 
            20                  25                  30          


Arg Pro Arg Phe Leu Glu Tyr Ser Thr Ser Glu Cys His Phe Phe Asn 
        35                  40                  45              


Gly Thr Glu Arg Val Arg Phe Leu Asp Arg Tyr Phe Tyr Asn Gln Glu 
    50                  55                  60                  


Glu Tyr Val Arg Phe Asp Ser Asp Val Gly Glu Tyr Arg Ala Val Thr 
65                  70                  75                  80  


Glu Leu Gly Arg Pro Ser Ala Glu Tyr Trp Asn Ser Gln Lys Asp Ile 
                85                  90                  95      


Leu Glu Asp Lys Arg Ala Ala Val Asp Thr Tyr Cys Arg His Asn Tyr 
            100                 105                 110         


Gly Val Gly Glu Ser Phe Thr Val Gln Arg Arg Val His Pro Lys Val 
        115                 120                 125             


Thr Val Tyr Pro Ser Lys Thr Gln Pro Leu Gln His His Asn Leu Leu 
    130                 135                 140                 


Val Cys Ser Val Ser Gly Phe Tyr Pro Gly Ser Ile Glu Val Arg Trp 
145                 150                 155                 160 


Phe Arg Asn Gly Gln Glu Glu Lys Thr Gly Val Val Ser Thr Gly Leu 
                165                 170                 175     


Ile His Asn Gly Asp Trp Thr Phe Gln Thr Leu Val Met Leu Glu Thr 
            180                 185                 190         


Val Pro Arg Ser Gly Glu Val Tyr Thr Cys Gln Val Glu His Pro Ser 
        195                 200                 205             


Val Thr Ser Pro Leu Thr Val Glu Trp Arg Ala Arg Ser Glu Ser Ala 
    210                 215                 220                 


Gln Ser Lys Met Leu Ser Gly Val Gly Gly Phe Val Leu Gly Leu Leu 
225                 230                 235                 240 


Phe Leu Gly Ala Gly Leu Phe Ile Tyr Phe Arg Asn Gln Lys Gly His 
                245                 250                 255     


Ser Gly Leu Gln Pro Arg Gly Phe Leu Ser 
            260                 265     


<210>  43
<211>  266
<212>  PRT
<213>  Homo sapiens

<400>  43

Met Val Cys Leu Arg Leu Pro Gly Gly Ser Cys Met Ala Val Leu Thr 
1               5                   10                  15      


Val Thr Leu Met Val Leu Ser Ser Pro Leu Ala Leu Ala Gly Asp Thr 
            20                  25                  30          


Arg Pro Arg Phe Leu Glu Tyr Ser Thr Ser Glu Cys His Phe Phe Asn 
        35                  40                  45              


Gly Thr Glu Arg Val Arg Phe Leu Asp Arg Tyr Phe His Asn Gln Glu 
    50                  55                  60                  


Glu Phe Val Arg Phe Asp Ser Asp Val Gly Glu Tyr Arg Ala Val Thr 
65                  70                  75                  80  


Glu Leu Gly Arg Pro Ala Ala Glu His Trp Asn Ser Gln Lys Asp Leu 
                85                  90                  95      


Leu Glu Arg Arg Arg Ala Glu Val Asp Thr Tyr Cys Arg His Asn Tyr 
            100                 105                 110         


Gly Val Val Glu Ser Phe Thr Val Gln Arg Arg Val His Pro Lys Val 
        115                 120                 125             


Thr Val Tyr Pro Ser Lys Thr Gln Pro Leu Gln His Tyr Asn Leu Leu 
    130                 135                 140                 


Val Cys Ser Val Ser Gly Phe Tyr Pro Gly Ser Ile Glu Val Arg Trp 
145                 150                 155                 160 


Phe Arg Asn Gly Gln Glu Glu Lys Thr Gly Val Val Ser Thr Gly Leu 
                165                 170                 175     


Ile His Asn Gly Asp Trp Thr Phe Gln Thr Leu Val Met Leu Glu Thr 
            180                 185                 190         


Val Pro Arg Ser Gly Glu Val Tyr Thr Cys Gln Val Glu His Pro Ser 
        195                 200                 205             


Val Thr Ser Pro Leu Thr Val Glu Trp Arg Ala Arg Ser Glu Ser Ala 
    210                 215                 220                 


Gln Ser Lys Met Leu Ser Gly Val Gly Gly Phe Val Leu Gly Leu Leu 
225                 230                 235                 240 


Phe Leu Gly Ala Gly Leu Phe Ile Tyr Phe Arg Asn Gln Lys Gly His 
                245                 250                 255     


Ser Gly Leu Gln Pro Arg Gly Phe Leu Ser 
            260                 265     


<210>  44
<211>  266
<212>  PRT
<213>  Homo sapiens

<400>  44

Met Val Cys Leu Arg Leu Pro Gly Gly Ser Cys Met Ala Val Leu Thr 
1               5                   10                  15      


Val Thr Leu Met Val Leu Ser Ser Pro Leu Ala Leu Ala Gly Asp Thr 
            20                  25                  30          


Arg Pro Arg Phe Leu Glu Tyr Ser Thr Ser Glu Cys His Phe Phe Asn 
        35                  40                  45              


Gly Thr Glu Arg Val Arg Phe Leu Glu Arg Tyr Phe His Asn Gln Glu 
    50                  55                  60                  


Glu Asn Val Arg Phe Asp Ser Asp Val Gly Glu Tyr Arg Ala Val Thr 
65                  70                  75                  80  


Glu Leu Gly Arg Pro Asp Ala Glu Tyr Trp Asn Ser Gln Lys Asp Leu 
                85                  90                  95      


Leu Glu Gln Arg Arg Ala Ala Val Asp Thr Tyr Cys Arg His Asn Tyr 
            100                 105                 110         


Gly Val Gly Glu Ser Phe Thr Val Gln Arg Arg Val His Pro Lys Val 
        115                 120                 125             


Thr Val Tyr Pro Ser Lys Thr Gln Pro Leu Gln His His Asn Leu Leu 
    130                 135                 140                 


Val Cys Ser Val Ser Gly Phe Tyr Pro Gly Ser Ile Glu Val Arg Trp 
145                 150                 155                 160 


Phe Arg Asn Gly Gln Glu Glu Lys Thr Gly Val Val Ser Thr Gly Leu 
                165                 170                 175     


Ile His Asn Gly Asp Trp Thr Phe Gln Thr Leu Val Met Leu Glu Thr 
            180                 185                 190         


Val Pro Arg Ser Gly Glu Val Tyr Thr Cys Gln Val Glu His Pro Ser 
        195                 200                 205             


Val Thr Ser Pro Leu Thr Val Glu Trp Arg Ala Arg Ser Glu Ser Ala 
    210                 215                 220                 


Gln Ser Lys Met Leu Ser Gly Val Gly Gly Phe Val Leu Gly Leu Leu 
225                 230                 235                 240 


Phe Leu Gly Ala Gly Leu Phe Ile Tyr Phe Arg Asn Gln Lys Gly His 
                245                 250                 255     


Ser Gly Leu Gln Pro Arg Gly Phe Leu Ser 
            260                 265     


<210>  45
<211>  266
<212>  PRT
<213>  Homo sapiens

<400>  45

Met Val Cys Leu Arg Leu Pro Gly Gly Ser Cys Met Ala Val Leu Thr 
1               5                   10                  15      


Val Thr Leu Met Val Leu Ser Ser Pro Leu Ala Leu Ala Gly Asp Thr 
            20                  25                  30          


Arg Pro Arg Phe Leu Glu Tyr Ser Thr Ser Glu Cys Gln Phe Phe Asn 
        35                  40                  45              


Gly Thr Glu Arg Val Arg Phe Leu Asp Arg Tyr Phe His Asn Gln Glu 
    50                  55                  60                  


Glu Phe Val Arg Phe Asp Ser Asp Val Gly Glu Tyr Arg Ala Val Thr 
65                  70                  75                  80  


Glu Leu Gly Arg Pro Asp Ala Glu Tyr Trp Asn Ser Gln Lys Asp Leu 
                85                  90                  95      


Leu Glu Arg Arg Arg Ala Glu Val Asp Thr Tyr Cys Arg His Asn Tyr 
            100                 105                 110         


Gly Val Val Glu Ser Phe Thr Val Gln Arg Arg Val His Pro Lys Val 
        115                 120                 125             


Thr Val Tyr Pro Ser Lys Thr Gln Pro Leu Gln His His Asn Leu Leu 
    130                 135                 140                 


Val Cys Ser Val Ser Gly Phe Tyr Pro Gly Ser Ile Glu Val Arg Trp 
145                 150                 155                 160 


Phe Arg Asn Gly Gln Glu Glu Lys Thr Gly Val Val Ser Thr Gly Leu 
                165                 170                 175     


Ile His Asn Gly Asp Trp Thr Phe Gln Thr Leu Val Met Leu Glu Thr 
            180                 185                 190         


Val Pro Arg Ser Gly Glu Val Tyr Thr Cys Gln Val Glu His Pro Ser 
        195                 200                 205             


Val Thr Ser Pro Leu Thr Val Glu Trp Arg Ala Arg Ser Glu Ser Ala 
    210                 215                 220                 


Gln Ser Lys Met Leu Ser Gly Val Gly Gly Phe Val Leu Gly Leu Leu 
225                 230                 235                 240 


Phe Leu Gly Ala Gly Leu Phe Ile Tyr Phe Arg Asn Gln Lys Gly His 
                245                 250                 255     


Ser Gly Leu Gln Pro Arg Gly Phe Leu Ser 
            260                 265     


<210>  46
<211>  266
<212>  PRT
<213>  Homo sapiens

<400>  46

Met Val Cys Leu Arg Leu Pro Gly Gly Ser Cys Met Ala Val Leu Thr 
1               5                   10                  15      


Val Thr Leu Met Val Leu Ser Ser Pro Leu Ala Leu Ala Gly Asp Thr 
            20                  25                  30          


Arg Pro Arg Phe Leu Glu Tyr Ser Thr Ser Glu Cys His Phe Phe Asn 
        35                  40                  45              


Gly Thr Glu Arg Val Arg Phe Leu Glu Arg Tyr Phe His Asn Gln Glu 
    50                  55                  60                  


Glu Asn Val Arg Phe Asp Ser Asp Val Gly Glu Tyr Arg Ala Val Thr 
65                  70                  75                  80  


Glu Leu Gly Arg Pro Asp Ala Glu Tyr Trp Asn Ser Gln Lys Asp Leu 
                85                  90                  95      


Leu Glu Gln Arg Arg Ala Ala Val Asp Thr Tyr Cys Arg His Asn Tyr 
            100                 105                 110         


Gly Val Val Glu Ser Phe Thr Val Gln Arg Arg Val His Pro Lys Val 
        115                 120                 125             


Thr Val Tyr Pro Ser Lys Thr Gln Pro Leu Gln His His Asn Leu Leu 
    130                 135                 140                 


Val Cys Ser Val Ser Gly Phe Tyr Pro Gly Ser Ile Glu Val Arg Trp 
145                 150                 155                 160 


Phe Arg Asn Gly Gln Glu Glu Lys Thr Gly Val Val Ser Thr Gly Leu 
                165                 170                 175     


Ile His Asn Gly Asp Trp Thr Phe Gln Thr Leu Val Met Leu Glu Thr 
            180                 185                 190         


Val Pro Arg Ser Gly Glu Val Tyr Thr Cys Gln Val Glu His Pro Ser 
        195                 200                 205             


Val Thr Ser Pro Leu Thr Val Glu Trp Arg Ala Arg Ser Glu Ser Ala 
    210                 215                 220                 


Gln Ser Lys Met Leu Ser Gly Val Gly Gly Phe Val Leu Gly Leu Leu 
225                 230                 235                 240 


Phe Leu Gly Ala Gly Leu Phe Ile Tyr Phe Arg Asn Gln Lys Gly His 
                245                 250                 255     


Ser Gly Leu Gln Pro Arg Gly Phe Leu Ser 
            260                 265     


<210>  47
<211>  266
<212>  PRT
<213>  Homo sapiens

<400>  47

Met Val Cys Leu Lys Leu Pro Gly Gly Ser Cys Met Thr Ala Leu Thr 
1               5                   10                  15      


Val Thr Leu Met Val Leu Ser Ser Pro Leu Ala Leu Ser Gly Asp Thr 
            20                  25                  30          


Arg Pro Arg Phe Leu Trp Gln Pro Lys Arg Glu Cys His Phe Phe Asn 
        35                  40                  45              


Gly Thr Glu Arg Val Arg Phe Leu Asp Arg Tyr Phe Tyr Asn Gln Glu 
    50                  55                  60                  


Glu Ser Val Arg Phe Asp Ser Asp Val Gly Glu Phe Arg Ala Val Thr 
65                  70                  75                  80  


Glu Leu Gly Arg Pro Asp Ala Glu Tyr Trp Asn Ser Gln Lys Asp Ile 
                85                  90                  95      


Leu Glu Gln Ala Arg Ala Ala Val Asp Thr Tyr Cys Arg His Asn Tyr 
            100                 105                 110         


Gly Val Val Glu Ser Phe Thr Val Gln Arg Arg Val Gln Pro Lys Val 
        115                 120                 125             


Thr Val Tyr Pro Ser Lys Thr Gln Pro Leu Gln His His Asn Leu Leu 
    130                 135                 140                 


Val Cys Ser Val Ser Gly Phe Tyr Pro Gly Ser Ile Glu Val Arg Trp 
145                 150                 155                 160 


Phe Leu Asn Gly Gln Glu Glu Lys Ala Gly Met Val Ser Thr Gly Leu 
                165                 170                 175     


Ile Gln Asn Gly Asp Trp Thr Phe Gln Thr Leu Val Met Leu Glu Thr 
            180                 185                 190         


Val Pro Arg Ser Gly Glu Val Tyr Thr Cys Gln Val Glu His Pro Ser 
        195                 200                 205             


Val Thr Ser Pro Leu Thr Val Glu Trp Arg Ala Arg Ser Glu Ser Ala 
    210                 215                 220                 


Gln Ser Lys Met Leu Ser Gly Val Gly Gly Phe Val Leu Gly Leu Leu 
225                 230                 235                 240 


Phe Leu Gly Ala Gly Leu Phe Ile Tyr Phe Arg Asn Gln Lys Gly His 
                245                 250                 255     


Ser Gly Leu Gln Pro Thr Gly Phe Leu Ser 
            260                 265     


<210>  48
<211>  266
<212>  PRT
<213>  Homo sapiens

<400>  48

Met Val Cys Leu Lys Leu Pro Gly Gly Ser Cys Met Thr Ala Leu Thr 
1               5                   10                  15      


Val Thr Leu Met Val Leu Ser Ser Pro Leu Ala Leu Ser Gly Asp Thr 
            20                  25                  30          


Arg Pro Arg Phe Leu Trp Gln Pro Lys Arg Glu Cys His Phe Phe Asn 
        35                  40                  45              


Gly Thr Glu Arg Val Arg Phe Leu Asp Arg Tyr Phe Tyr Asn Gln Glu 
    50                  55                  60                  


Glu Ser Val Arg Phe Asp Ser Asp Val Gly Glu Phe Arg Ala Val Thr 
65                  70                  75                  80  


Glu Leu Gly Arg Pro Asp Ala Glu Tyr Trp Asn Ser Gln Lys Asp Ile 
                85                  90                  95      


Leu Glu Gln Ala Arg Ala Ala Val Asp Thr Tyr Cys Arg His Asn Tyr 
            100                 105                 110         


Gly Val Gly Glu Ser Phe Thr Val Gln Arg Arg Val Gln Pro Lys Val 
        115                 120                 125             


Thr Val Tyr Pro Ser Lys Thr Gln Pro Leu Gln His His Asn Leu Leu 
    130                 135                 140                 


Val Cys Ser Val Ser Gly Phe Tyr Pro Gly Ser Ile Glu Val Arg Trp 
145                 150                 155                 160 


Phe Leu Asn Gly Gln Glu Glu Lys Ala Gly Met Val Ser Thr Gly Leu 
                165                 170                 175     


Ile Gln Asn Gly Asp Trp Thr Phe Gln Thr Leu Val Met Leu Glu Thr 
            180                 185                 190         


Val Pro Arg Ser Gly Glu Val Tyr Thr Cys Gln Val Glu His Pro Ser 
        195                 200                 205             


Val Thr Ser Pro Leu Thr Val Glu Trp Arg Ala Arg Ser Glu Ser Ala 
    210                 215                 220                 


Gln Ser Lys Met Leu Ser Gly Val Gly Gly Phe Val Leu Gly Leu Leu 
225                 230                 235                 240 


Phe Leu Gly Ala Gly Leu Phe Ile Tyr Phe Arg Asn Gln Lys Gly His 
                245                 250                 255     


Ser Gly Leu Gln Pro Thr Gly Phe Leu Ser 
            260                 265     


<210>  49
<211>  266
<212>  PRT
<213>  Homo sapiens

<400>  49

Met Val Cys Leu Lys Leu Pro Gly Gly Ser Cys Met Thr Ala Leu Thr 
1               5                   10                  15      


Val Thr Leu Met Val Leu Ser Ser Pro Leu Ala Leu Ser Gly Asp Thr 
            20                  25                  30          


Arg Pro Arg Phe Leu Trp Gln Pro Lys Arg Glu Cys His Phe Phe Asn 
        35                  40                  45              


Gly Thr Glu Arg Val Arg Phe Leu Asp Arg His Phe Tyr Asn Gln Glu 
    50                  55                  60                  


Glu Ser Val Arg Phe Asp Ser Asp Val Gly Glu Phe Arg Ala Val Thr 
65                  70                  75                  80  


Glu Leu Gly Arg Pro Asp Ala Glu Tyr Trp Asn Ser Gln Lys Asp Ile 
                85                  90                  95      


Leu Glu Gln Ala Arg Ala Ala Val Asp Thr Tyr Cys Arg His Asn Tyr 
            100                 105                 110         


Gly Val Val Glu Ser Phe Thr Val Gln Arg Arg Val Gln Pro Lys Val 
        115                 120                 125             


Thr Val Tyr Pro Ser Lys Thr Gln Pro Leu Gln His His Asn Leu Leu 
    130                 135                 140                 


Val Cys Ser Val Ser Gly Phe Tyr Pro Gly Ser Ile Glu Val Arg Trp 
145                 150                 155                 160 


Phe Leu Asn Gly Gln Glu Glu Lys Ala Gly Met Val Ser Thr Gly Leu 
                165                 170                 175     


Ile Gln Asn Gly Asp Trp Thr Phe Gln Thr Leu Val Met Leu Glu Thr 
            180                 185                 190         


Val Pro Arg Ser Gly Glu Val Tyr Thr Cys Gln Val Glu His Pro Ser 
        195                 200                 205             


Val Thr Ser Pro Leu Thr Val Glu Trp Arg Ala Arg Ser Glu Ser Ala 
    210                 215                 220                 


Gln Ser Lys Met Leu Ser Gly Val Gly Gly Phe Val Leu Gly Leu Leu 
225                 230                 235                 240 


Phe Leu Gly Ala Gly Leu Phe Ile Tyr Phe Arg Asn Gln Lys Gly His 
                245                 250                 255     


Ser Gly Leu Gln Pro Thr Gly Phe Leu Ser 
            260                 265     


<210>  50
<211>  266
<212>  PRT
<213>  Homo sapiens

<400>  50

Met Val Cys Leu Lys Leu Pro Gly Gly Ser Cys Met Thr Ala Leu Thr 
1               5                   10                  15      


Val Thr Leu Met Val Leu Ser Ser Pro Leu Ala Leu Ser Gly Asp Thr 
            20                  25                  30          


Arg Pro Arg Phe Leu Trp Gln Pro Lys Arg Glu Cys His Phe Phe Asn 
        35                  40                  45              


Gly Thr Glu Arg Val Arg Phe Leu Asp Arg Tyr Phe Tyr Asn Gln Glu 
    50                  55                  60                  


Glu Ser Val Arg Phe Asp Ser Asp Val Gly Glu Phe Arg Ala Val Thr 
65                  70                  75                  80  


Glu Leu Gly Arg Pro Asp Ala Glu Tyr Trp Asn Ser Gln Lys Asp Phe 
                85                  90                  95      


Leu Glu Gln Ala Arg Ala Ala Val Asp Thr Tyr Cys Arg His Asn Tyr 
            100                 105                 110         


Gly Val Val Glu Ser Phe Thr Val Gln Arg Arg Val Gln Pro Lys Val 
        115                 120                 125             


Thr Val Tyr Pro Ser Lys Thr Gln Pro Leu Gln His His Asn Leu Leu 
    130                 135                 140                 


Val Cys Ser Val Ser Gly Phe Tyr Pro Gly Ser Ile Glu Val Arg Trp 
145                 150                 155                 160 


Phe Leu Asn Gly Gln Glu Glu Lys Ala Gly Met Val Ser Thr Gly Leu 
                165                 170                 175     


Ile Gln Asn Gly Asp Trp Thr Phe Gln Thr Leu Val Met Leu Glu Thr 
            180                 185                 190         


Val Pro Arg Ser Gly Glu Val Tyr Thr Cys Gln Val Glu His Pro Ser 
        195                 200                 205             


Val Thr Ser Pro Leu Thr Val Glu Trp Arg Ala Arg Ser Glu Ser Ala 
    210                 215                 220                 


Gln Ser Lys Met Leu Ser Gly Val Gly Gly Phe Val Leu Gly Leu Leu 
225                 230                 235                 240 


Phe Leu Gly Ala Gly Leu Phe Ile Tyr Phe Arg Asn Gln Lys Gly His 
                245                 250                 255     


Ser Gly Leu Gln Pro Thr Gly Phe Leu Ser 
            260                 265     


<210>  51
<211>  266
<212>  PRT
<213>  Homo sapiens

<400>  51

Met Val Cys Leu Lys Leu Pro Gly Gly Ser Cys Met Thr Ala Leu Thr 
1               5                   10                  15      


Val Thr Leu Met Val Leu Ser Ser Pro Leu Ala Leu Ser Gly Asp Thr 
            20                  25                  30          


Arg Pro Arg Phe Leu Trp Gln Pro Lys Arg Glu Cys His Phe Phe Asn 
        35                  40                  45              


Gly Thr Glu Arg Val Arg Phe Leu Asp Arg Tyr Phe Tyr Asn Gln Glu 
    50                  55                  60                  


Glu Ser Val Arg Phe Asp Ser Asp Val Gly Glu Phe Arg Ala Val Thr 
65                  70                  75                  80  


Glu Leu Gly Arg Pro Asp Ala Glu Tyr Trp Asn Ser Gln Lys Asp Ile 
                85                  90                  95      


Leu Glu Gln Ala Arg Ala Ala Val Asp Thr Tyr Cys Arg His Asn Tyr 
            100                 105                 110         


Gly Val Val Glu Ser Phe Thr Val Gln Arg Arg Val Gln Pro Lys Val 
        115                 120                 125             


Thr Val Tyr Pro Ser Lys Thr Gln Pro Leu Gln His His Asn Leu Leu 
    130                 135                 140                 


Val Cys Ser Val Ser Gly Phe Tyr Pro Gly Ser Ile Glu Val Arg Trp 
145                 150                 155                 160 


Phe Leu Asn Gly Gln Glu Glu Lys Ala Gly Met Val Ser Thr Gly Leu 
                165                 170                 175     


Ile Gln Asn Gly Asp Trp Thr Phe Gln Thr Leu Val Met Leu Glu Thr 
            180                 185                 190         


Val Pro Arg Ser Gly Glu Val Tyr Thr Cys Gln Val Glu His Pro Ser 
        195                 200                 205             


Val Thr Ser Pro Leu Thr Val Glu Trp Arg Ala Arg Ser Glu Ser Ala 
    210                 215                 220                 


Gln Ser Lys Met Leu Ser Gly Val Gly Gly Phe Val Leu Gly Leu Leu 
225                 230                 235                 240 


Phe Leu Gly Ala Gly Leu Phe Ile Tyr Phe Arg Asn Gln Lys Gly His 
                245                 250                 255     


Ser Gly Leu Gln Pro Thr Gly Phe Leu Ser 
            260                 265     


<210>  52
<211>  266
<212>  PRT
<213>  Homo sapiens

<400>  52

Met Val Cys Leu Lys Leu Pro Gly Gly Ser Cys Met Thr Ala Leu Thr 
1               5                   10                  15      


Val Thr Leu Met Val Leu Ser Ser Pro Leu Ala Leu Ser Gly Asp Thr 
            20                  25                  30          


Arg Pro Arg Phe Leu Trp Gln Pro Lys Arg Glu Cys His Phe Phe Asn 
        35                  40                  45              


Gly Thr Glu Arg Val Arg Phe Leu Asp Arg Tyr Phe Tyr Asn Gln Glu 
    50                  55                  60                  


Glu Ser Val Arg Phe Asp Ser Asp Val Gly Glu Phe Arg Ala Val Thr 
65                  70                  75                  80  


Glu Leu Gly Arg Pro Asp Ala Glu Tyr Trp Asn Ser Gln Lys Asp Ile 
                85                  90                  95      


Leu Glu Gln Ala Arg Ala Ala Val Asp Thr Tyr Cys Arg His Asn Tyr 
            100                 105                 110         


Gly Val Val Glu Ser Phe Thr Val Gln Arg Arg Val Gln Pro Lys Val 
        115                 120                 125             


Thr Val Tyr Pro Ser Lys Thr Gln Pro Leu Gln His His Asn Leu Leu 
    130                 135                 140                 


Val Cys Ser Val Ser Gly Phe Tyr Pro Gly Ser Ile Glu Val Arg Trp 
145                 150                 155                 160 


Phe Leu Asn Gly Gln Glu Glu Lys Ala Gly Met Val Ser Thr Gly Leu 
                165                 170                 175     


Ile Gln Asn Gly Asp Trp Thr Phe Gln Thr Leu Val Met Leu Glu Thr 
            180                 185                 190         


Val Pro Arg Ser Gly Glu Val Tyr Thr Cys Gln Val Glu His Pro Ser 
        195                 200                 205             


Val Thr Ser Pro Leu Thr Val Glu Trp Arg Ala Arg Ser Glu Ser Ala 
    210                 215                 220                 


Gln Ser Lys Met Leu Ser Gly Val Gly Gly Phe Val Leu Gly Leu Leu 
225                 230                 235                 240 


Phe Leu Gly Ala Gly Leu Phe Ile Tyr Phe Arg Asn Gln Lys Gly His 
                245                 250                 255     


Ser Gly Leu Gln Pro Thr Gly Phe Leu Ser 
            260                 265     


<210>  53
<211>  266
<212>  PRT
<213>  Homo sapiens

<400>  53

Met Val Cys Leu Lys Leu Pro Gly Gly Ser Cys Met Thr Ala Leu Thr 
1               5                   10                  15      


Val Thr Leu Met Val Leu Ser Ser Pro Leu Ala Leu Ser Gly Asp Thr 
            20                  25                  30          


Arg Pro Arg Phe Leu Trp Gln Pro Lys Arg Glu Cys His Phe Phe Asn 
        35                  40                  45              


Gly Thr Glu Arg Val Arg Phe Leu Asp Arg Tyr Phe Tyr Asn Gln Glu 
    50                  55                  60                  


Glu Ser Val Arg Phe Asp Ser Asp Val Gly Glu Tyr Arg Ala Val Thr 
65                  70                  75                  80  


Glu Leu Gly Arg Pro Asp Ala Glu Tyr Trp Asn Ser Gln Lys Asp Ile 
                85                  90                  95      


Leu Glu Gln Ala Arg Ala Ala Val Asp Thr Tyr Cys Arg His Asn Tyr 
            100                 105                 110         


Gly Val Val Glu Ser Phe Thr Val Gln Arg Arg Val Gln Pro Lys Val 
        115                 120                 125             


Thr Val Tyr Pro Ser Lys Thr Gln Pro Leu Gln His His Asn Leu Leu 
    130                 135                 140                 


Val Cys Ser Val Ser Gly Phe Tyr Pro Gly Ser Ile Glu Val Arg Trp 
145                 150                 155                 160 


Phe Leu Asn Gly Gln Glu Glu Lys Ala Gly Met Val Ser Thr Gly Leu 
                165                 170                 175     


Ile Gln Asn Gly Asp Trp Thr Phe Gln Thr Leu Val Met Leu Glu Thr 
            180                 185                 190         


Val Pro Arg Ser Gly Glu Val Tyr Thr Cys Gln Val Glu His Pro Ser 
        195                 200                 205             


Val Thr Ser Pro Leu Thr Val Glu Trp Arg Ala Arg Ser Glu Ser Ala 
    210                 215                 220                 


Gln Ser Lys Met Leu Ser Gly Val Gly Gly Phe Val Leu Gly Leu Leu 
225                 230                 235                 240 


Phe Leu Gly Ala Gly Leu Phe Ile Tyr Phe Arg Asn Gln Lys Gly His 
                245                 250                 255     


Ser Gly Leu Gln Pro Thr Gly Phe Leu Ser 
            260                 265     


<210>  54
<211>  266
<212>  PRT
<213>  Homo sapiens

<400>  54

Met Val Cys Leu Lys Leu Pro Gly Gly Ser Cys Met Thr Ala Leu Thr 
1               5                   10                  15      


Val Thr Leu Met Val Leu Ser Ser Pro Leu Ala Leu Ala Gly Asp Thr 
            20                  25                  30          


Arg Pro Arg Phe Leu Trp Gln Pro Lys Arg Glu Cys His Phe Phe Asn 
        35                  40                  45              


Gly Thr Glu Arg Val Arg Phe Leu Asp Arg Tyr Phe Tyr Asn Gln Glu 
    50                  55                  60                  


Glu Ser Val Arg Phe Asp Ser Asp Val Gly Glu Tyr Arg Ala Val Thr 
65                  70                  75                  80  


Glu Leu Gly Arg Pro Asp Ala Glu Tyr Trp Asn Ser Gln Lys Asp Phe 
                85                  90                  95      


Leu Glu Asp Arg Arg Ala Ala Val Asp Thr Tyr Cys Arg His Asn Tyr 
            100                 105                 110         


Gly Val Gly Glu Ser Phe Thr Val Gln Arg Arg Val Gln Pro Lys Val 
        115                 120                 125             


Thr Val Tyr Pro Ser Lys Thr Gln Pro Leu Gln His His Asn Leu Leu 
    130                 135                 140                 


Val Cys Ser Val Ser Gly Phe Tyr Pro Gly Ser Ile Glu Val Arg Trp 
145                 150                 155                 160 


Phe Leu Asn Gly Gln Glu Glu Lys Ala Gly Met Val Ser Thr Gly Leu 
                165                 170                 175     


Ile Gln Asn Gly Asp Trp Thr Phe Gln Thr Leu Val Met Leu Glu Thr 
            180                 185                 190         


Val Pro Arg Ser Gly Glu Val Tyr Thr Cys Gln Val Glu His Pro Ser 
        195                 200                 205             


Val Thr Ser Pro Leu Thr Val Glu Trp Arg Ala Arg Ser Glu Ser Ala 
    210                 215                 220                 


Gln Ser Lys Met Leu Ser Gly Val Gly Gly Phe Val Leu Gly Leu Leu 
225                 230                 235                 240 


Phe Leu Gly Ala Gly Leu Phe Ile Tyr Phe Arg Asn Gln Lys Gly His 
                245                 250                 255     


Ser Gly Leu Gln Pro Thr Gly Phe Leu Ser 
            260                 265     


<210>  55
<211>  266
<212>  PRT
<213>  Homo sapiens

<400>  55

Met Val Cys Leu Lys Leu Pro Gly Gly Ser Ser Leu Ala Ala Leu Thr 
1               5                   10                  15      


Val Thr Leu Met Val Leu Ser Ser Arg Leu Ala Phe Ala Gly Asp Thr 
            20                  25                  30          


Arg Pro Arg Phe Leu Glu Leu Arg Lys Ser Glu Cys His Phe Phe Asn 
        35                  40                  45              


Gly Thr Glu Arg Val Arg Tyr Leu Asp Arg Tyr Phe His Asn Gln Glu 
    50                  55                  60                  


Glu Phe Leu Arg Phe Asp Ser Asp Val Gly Glu Tyr Arg Ala Val Thr 
65                  70                  75                  80  


Glu Leu Gly Arg Pro Val Ala Glu Ser Trp Asn Ser Gln Lys Asp Leu 
                85                  90                  95      


Leu Glu Gln Lys Arg Gly Arg Val Asp Asn Tyr Cys Arg His Asn Tyr 
            100                 105                 110         


Gly Val Gly Glu Ser Phe Thr Val Gln Arg Arg Val His Pro Gln Val 
        115                 120                 125             


Thr Val Tyr Pro Ala Lys Thr Gln Pro Leu Gln His His Asn Leu Leu 
    130                 135                 140                 


Val Cys Ser Val Ser Gly Phe Tyr Pro Gly Ser Ile Glu Val Arg Trp 
145                 150                 155                 160 


Phe Arg Asn Gly Gln Glu Glu Lys Ala Gly Val Val Ser Thr Gly Leu 
                165                 170                 175     


Ile Gln Asn Gly Asp Trp Thr Phe Gln Thr Leu Val Met Leu Glu Thr 
            180                 185                 190         


Val Pro Arg Ser Gly Glu Val Tyr Thr Cys Gln Val Glu His Pro Ser 
        195                 200                 205             


Val Thr Ser Ala Leu Thr Val Glu Trp Arg Ala Arg Ser Glu Ser Ala 
    210                 215                 220                 


Gln Ser Lys Met Leu Ser Gly Val Gly Gly Phe Val Leu Gly Leu Leu 
225                 230                 235                 240 


Phe Leu Gly Ala Gly Leu Phe Ile Tyr Phe Arg Asn Gln Lys Gly His 
                245                 250                 255     


Ser Gly Leu Gln Pro Thr Gly Phe Leu Ser 
            260                 265     


<210>  56
<211>  266
<212>  PRT
<213>  Homo sapiens

<400>  56

Met Val Cys Leu Lys Leu Pro Gly Gly Ser Ser Leu Ala Ala Leu Thr 
1               5                   10                  15      


Val Thr Leu Met Val Leu Ser Ser Arg Leu Ala Phe Ala Gly Asp Thr 
            20                  25                  30          


Arg Pro Arg Phe Leu Glu Leu Arg Lys Ser Glu Cys His Phe Phe Asn 
        35                  40                  45              


Gly Thr Glu Arg Val Arg Tyr Leu Asp Arg Tyr Phe His Asn Gln Glu 
    50                  55                  60                  


Glu Phe Leu Arg Phe Asp Ser Asp Val Gly Glu Tyr Arg Ala Val Thr 
65                  70                  75                  80  


Glu Leu Gly Arg Pro Val Ala Glu Ser Trp Asn Ser Gln Lys Asp Leu 
                85                  90                  95      


Leu Glu Gln Lys Arg Gly Gln Val Asp Asn Tyr Cys Arg His Asn Tyr 
            100                 105                 110         


Gly Val Val Glu Ser Phe Thr Val Gln Arg Arg Val His Pro Gln Val 
        115                 120                 125             


Thr Val Tyr Pro Ala Lys Thr Gln Pro Leu Gln His His Asn Leu Leu 
    130                 135                 140                 


Val Cys Ser Val Ser Gly Phe Tyr Pro Gly Ser Ile Glu Val Arg Trp 
145                 150                 155                 160 


Phe Arg Asn Gly Gln Glu Glu Lys Ala Gly Val Val Ser Thr Gly Leu 
                165                 170                 175     


Ile Gln Asn Gly Asp Trp Thr Phe Gln Thr Leu Val Met Leu Glu Thr 
            180                 185                 190         


Val Pro Arg Ser Gly Glu Val Tyr Thr Cys Gln Val Glu His Pro Ser 
        195                 200                 205             


Val Thr Ser Ala Leu Thr Val Glu Trp Arg Ala Arg Ser Glu Ser Ala 
    210                 215                 220                 


Gln Ser Lys Met Leu Ser Gly Val Gly Gly Phe Val Leu Gly Leu Leu 
225                 230                 235                 240 


Phe Leu Gly Ala Gly Leu Phe Ile Tyr Phe Arg Asn Gln Lys Gly His 
                245                 250                 255     


Ser Gly Leu Gln Pro Thr Gly Phe Leu Ser 
            260                 265     


<210>  57
<211>  266
<212>  PRT
<213>  Homo sapiens

<400>  57

Met Val Cys Leu Lys Leu Pro Gly Gly Ser Ser Leu Ala Ala Leu Thr 
1               5                   10                  15      


Val Thr Leu Met Val Leu Ser Ser Arg Leu Ala Phe Ala Gly Asp Thr 
            20                  25                  30          


Arg Pro Arg Phe Leu Glu Leu Leu Lys Ser Glu Cys His Phe Phe Asn 
        35                  40                  45              


Gly Thr Glu Arg Val Arg Phe Leu Glu Arg His Phe His Asn Gln Glu 
    50                  55                  60                  


Glu Tyr Ala Arg Phe Asp Ser Asp Val Gly Glu Tyr Arg Ala Val Arg 
65                  70                  75                  80  


Glu Leu Gly Arg Pro Asp Ala Glu Tyr Trp Asn Ser Gln Lys Asp Leu 
                85                  90                  95      


Leu Glu Gln Lys Arg Gly Gln Val Asp Asn Tyr Cys Arg His Asn Tyr 
            100                 105                 110         


Gly Val Val Glu Ser Phe Thr Val Gln Arg Arg Val His Pro Gln Val 
        115                 120                 125             


Thr Val Tyr Pro Ala Lys Thr Gln Pro Leu Gln His His Asn Leu Leu 
    130                 135                 140                 


Val Cys Ser Val Ser Gly Phe Tyr Pro Gly Ser Ile Glu Val Arg Trp 
145                 150                 155                 160 


Phe Arg Asn Gly Gln Glu Glu Lys Ala Gly Val Val Ser Thr Gly Leu 
                165                 170                 175     


Ile Gln Asn Gly Asp Trp Thr Phe Gln Thr Leu Val Met Leu Glu Thr 
            180                 185                 190         


Phe Pro Arg Ser Gly Glu Val Tyr Thr Cys Gln Val Glu His Pro Ser 
        195                 200                 205             


Val Thr Ser Pro Leu Thr Val Glu Trp Ser Ala Arg Ser Glu Ser Ala 
    210                 215                 220                 


Gln Ser Lys Met Leu Ser Gly Val Gly Gly Phe Val Leu Gly Leu Leu 
225                 230                 235                 240 


Phe Leu Gly Ala Gly Leu Phe Ile Tyr Phe Arg Asn Gln Lys Gly His 
                245                 250                 255     


Ser Gly Leu Gln Pro Thr Gly Phe Leu Ser 
            260                 265     


<210>  58
<211>  266
<212>  PRT
<213>  Homo sapiens

<400>  58

Met Val Cys Leu Lys Leu Pro Gly Gly Ser Ser Leu Ala Ala Leu Thr 
1               5                   10                  15      


Val Thr Leu Met Val Leu Ser Ser Arg Leu Ala Phe Ala Gly Asp Thr 
            20                  25                  30          


Arg Pro Arg Phe Leu Glu Leu Leu Lys Ser Glu Cys His Phe Phe Asn 
        35                  40                  45              


Gly Thr Glu Arg Val Arg Phe Leu Glu Arg Tyr Phe His Asn Gln Glu 
    50                  55                  60                  


Glu Phe Val Arg Phe Asp Ser Asp Val Gly Glu Tyr Arg Ala Val Thr 
65                  70                  75                  80  


Glu Leu Gly Arg Pro Val Ala Glu Ser Trp Asn Ser Gln Lys Asp Leu 
                85                  90                  95      


Leu Glu Gln Lys Arg Gly Gln Val Asp Asn Tyr Cys Arg His Asn Tyr 
            100                 105                 110         


Gly Val Val Glu Ser Phe Thr Val Gln Arg Arg Val His Pro Gln Val 
        115                 120                 125             


Thr Val Tyr Pro Ala Lys Thr Gln Pro Leu Gln His His Asn Leu Leu 
    130                 135                 140                 


Val Cys Ser Val Ser Gly Phe Tyr Pro Gly Ser Ile Glu Val Arg Trp 
145                 150                 155                 160 


Phe Arg Asn Gly Gln Glu Glu Lys Thr Gly Val Val Ser Thr Gly Leu 
                165                 170                 175     


Ile His Asn Gly Asp Trp Thr Phe Gln Thr Leu Val Met Leu Glu Thr 
            180                 185                 190         


Val Pro Arg Ser Gly Glu Val Tyr Thr Cys Gln Val Glu His Pro Ser 
        195                 200                 205             


Val Thr Ser Pro Leu Thr Val Glu Trp Arg Ala Arg Ser Glu Ser Ala 
    210                 215                 220                 


Gln Ser Lys Met Leu Ser Gly Val Gly Gly Phe Val Leu Gly Leu Leu 
225                 230                 235                 240 


Phe Leu Gly Ala Gly Leu Phe Ile Tyr Phe Arg Asn Gln Lys Gly His 
                245                 250                 255     


Ser Gly Leu Gln Pro Thr Gly Phe Leu Ser 
            260                 265     


<210>  59
<211>  266
<212>  PRT
<213>  Homo sapiens

<400>  59

Met Val Cys Leu Lys Leu Pro Gly Gly Ser Cys Met Ala Ala Leu Thr 
1               5                   10                  15      


Val Thr Leu Thr Val Leu Ser Ser Pro Leu Ala Leu Ala Gly Asp Thr 
            20                  25                  30          


Gln Pro Arg Phe Leu Glu Gln Ala Lys Cys Glu Cys His Phe Leu Asn 
        35                  40                  45              


Gly Thr Glu Arg Val Trp Asn Leu Ile Arg Tyr Ile Tyr Asn Gln Glu 
    50                  55                  60                  


Glu Tyr Ala Arg Tyr Asn Ser Asp Leu Gly Glu Tyr Gln Ala Val Thr 
65                  70                  75                  80  


Glu Leu Gly Arg Pro Asp Ala Glu Tyr Trp Asn Ser Gln Lys Asp Leu 
                85                  90                  95      


Leu Glu Arg Arg Arg Ala Glu Val Asp Thr Tyr Cys Arg Tyr Asn Tyr 
            100                 105                 110         


Gly Val Val Glu Ser Phe Thr Val Gln Arg Arg Val Gln Pro Lys Val 
        115                 120                 125             


Thr Val Tyr Pro Ser Lys Thr Gln Pro Leu Gln His His Asn Leu Leu 
    130                 135                 140                 


Val Cys Ser Val Asn Gly Phe Tyr Pro Gly Ser Ile Glu Val Arg Trp 
145                 150                 155                 160 


Phe Arg Asn Ser Gln Glu Glu Lys Ala Gly Val Val Ser Thr Gly Leu 
                165                 170                 175     


Ile Gln Asn Gly Asp Trp Thr Phe Gln Thr Leu Val Met Leu Glu Thr 
            180                 185                 190         


Val Pro Arg Ser Gly Glu Val Tyr Thr Cys Gln Val Glu His Pro Ser 
        195                 200                 205             


Met Met Ser Pro Leu Thr Val Gln Trp Ser Ala Arg Ser Glu Ser Ala 
    210                 215                 220                 


Gln Ser Lys Met Leu Ser Gly Val Gly Gly Phe Val Leu Gly Leu Leu 
225                 230                 235                 240 


Phe Leu Gly Thr Gly Leu Phe Ile Tyr Phe Arg Asn Gln Lys Gly His 
                245                 250                 255     


Ser Gly Leu Gln Pro Thr Gly Leu Leu Ser 
            260                 265     


<210>  60
<211>  266
<212>  PRT
<213>  Homo sapiens

<400>  60

Met Val Cys Leu Lys Leu Pro Gly Gly Ser Cys Met Ala Ala Leu Thr 
1               5                   10                  15      


Val Thr Leu Thr Val Leu Ser Ser Pro Leu Ala Leu Ala Gly Asp Thr 
            20                  25                  30          


Gln Pro Arg Phe Leu Glu Gln Ala Lys Cys Glu Cys His Phe Leu Asn 
        35                  40                  45              


Gly Thr Glu Arg Val Trp Asn Leu Ile Arg Tyr Ile Tyr Asn Gln Glu 
    50                  55                  60                  


Glu Tyr Ala Arg Tyr Asn Ser Asp Leu Gly Glu Tyr Gln Ala Val Thr 
65                  70                  75                  80  


Glu Leu Gly Arg Pro Asp Ala Glu Tyr Trp Asn Ser Gln Lys Asp Leu 
                85                  90                  95      


Leu Glu Arg Arg Arg Ala Glu Val Asp Thr Tyr Cys Arg Tyr Asn Tyr 
            100                 105                 110         


Gly Val Val Glu Ser Phe Thr Val Gln Arg Arg Val Gln Pro Lys Val 
        115                 120                 125             


Thr Val Tyr Pro Ser Lys Thr Gln Pro Leu Gln His His Asn Leu Leu 
    130                 135                 140                 


Val Cys Ser Val Asn Gly Phe Tyr Pro Gly Ser Ile Glu Val Arg Trp 
145                 150                 155                 160 


Phe Arg Asn Gly Gln Glu Glu Lys Ala Gly Val Val Ser Thr Gly Leu 
                165                 170                 175     


Ile Gln Asn Gly Asp Trp Thr Phe Gln Thr Leu Val Met Leu Glu Thr 
            180                 185                 190         


Val Pro Arg Ser Gly Glu Val Tyr Thr Cys Gln Val Glu His Pro Ser 
        195                 200                 205             


Met Met Ser Pro Leu Thr Val Gln Trp Ser Ala Arg Ser Glu Ser Ala 
    210                 215                 220                 


Gln Ser Lys Met Leu Ser Gly Val Gly Gly Phe Val Leu Gly Leu Leu 
225                 230                 235                 240 


Phe Leu Gly Thr Gly Leu Phe Ile Tyr Phe Arg Asn Gln Lys Gly His 
                245                 250                 255     


Ser Gly Leu Gln Pro Thr Gly Leu Leu Ser 
            260                 265     


<210>  61
<211>  266
<212>  PRT
<213>  Homo sapiens

<400>  61

Met Val Cys Leu Lys Leu Pro Gly Gly Ser Tyr Met Ala Lys Leu Thr 
1               5                   10                  15      


Val Thr Leu Met Val Leu Ser Ser Pro Leu Ala Leu Ala Gly Asp Thr 
            20                  25                  30          


Arg Pro Arg Phe Leu Gln Gln Asp Lys Tyr Glu Cys His Phe Phe Asn 
        35                  40                  45              


Gly Thr Glu Arg Val Arg Phe Leu His Arg Asp Ile Tyr Asn Gln Glu 
    50                  55                  60                  


Glu Asp Leu Arg Phe Asp Ser Asp Val Gly Glu Tyr Arg Ala Val Thr 
65                  70                  75                  80  


Glu Leu Gly Arg Pro Asp Ala Glu Tyr Trp Asn Ser Gln Lys Asp Phe 
                85                  90                  95      


Leu Glu Asp Arg Arg Ala Ala Val Asp Thr Tyr Cys Arg His Asn Tyr 
            100                 105                 110         


Gly Val Gly Glu Ser Phe Thr Val Gln Arg Arg Val Glu Pro Lys Val 
        115                 120                 125             


Thr Val Tyr Pro Ala Arg Thr Gln Thr Leu Gln His His Asn Leu Leu 
    130                 135                 140                 


Val Cys Ser Val Asn Gly Phe Tyr Pro Gly Ser Ile Glu Val Arg Trp 
145                 150                 155                 160 


Phe Arg Asn Ser Gln Glu Glu Lys Ala Gly Val Val Ser Thr Gly Leu 
                165                 170                 175     


Ile Gln Asn Gly Asp Trp Thr Phe Gln Thr Leu Val Met Leu Glu Thr 
            180                 185                 190         


Val Pro Arg Ser Gly Glu Val Tyr Thr Cys Gln Val Glu His Pro Ser 
        195                 200                 205             


Val Thr Ser Pro Leu Thr Val Glu Trp Arg Ala Gln Ser Glu Ser Ala 
    210                 215                 220                 


Gln Ser Lys Met Leu Ser Gly Val Gly Gly Phe Val Leu Gly Leu Leu 
225                 230                 235                 240 


Phe Leu Gly Ala Gly Leu Phe Ile Tyr Phe Lys Asn Gln Lys Gly His 
                245                 250                 255     


Ser Gly Leu His Pro Thr Gly Leu Val Ser 
            260                 265     


<210>  62
<211>  261
<212>  PRT
<213>  Homo sapiens

<400>  62

Met Gly His Glu Gln Asn Gln Gly Ala Ala Leu Leu Gln Met Leu Pro 
1               5                   10                  15      


Leu Leu Trp Leu Leu Pro His Ser Trp Ala Val Pro Glu Ala Pro Thr 
            20                  25                  30          


Pro Met Trp Pro Asp Asp Leu Gln Asn His Thr Phe Leu His Thr Val 
        35                  40                  45              


Tyr Cys Gln Asp Gly Ser Pro Ser Val Gly Leu Ser Glu Ala Tyr Asp 
    50                  55                  60                  


Glu Asp Gln Leu Phe Phe Phe Asp Phe Ser Gln Asn Thr Arg Val Pro 
65                  70                  75                  80  


Arg Leu Pro Glu Phe Ala Asp Trp Ala Gln Glu Gln Gly Asp Ala Pro 
                85                  90                  95      


Ala Ile Leu Phe Asp Lys Glu Phe Cys Glu Trp Met Ile Gln Gln Ile 
            100                 105                 110         


Gly Pro Lys Leu Asp Gly Lys Ile Pro Val Ser Arg Gly Phe Pro Ile 
        115                 120                 125             


Ala Glu Val Phe Thr Leu Lys Pro Leu Glu Phe Gly Lys Pro Asn Thr 
    130                 135                 140                 


Leu Val Cys Phe Val Ser Asn Leu Phe Pro Pro Met Leu Thr Val Asn 
145                 150                 155                 160 


Trp Gln His His Ser Val Pro Val Glu Gly Phe Gly Pro Thr Phe Val 
                165                 170                 175     


Ser Ala Val Asp Gly Leu Ser Phe Gln Ala Phe Ser Tyr Leu Asn Phe 
            180                 185                 190         


Thr Pro Glu Pro Ser Asp Ile Phe Ser Cys Ile Val Thr His Glu Ile 
        195                 200                 205             


Asp Arg Tyr Thr Ala Ile Ala Tyr Trp Val Pro Arg Asn Ala Leu Pro 
    210                 215                 220                 


Ser Asp Leu Leu Glu Asn Val Leu Cys Gly Val Ala Phe Gly Leu Gly 
225                 230                 235                 240 


Val Leu Gly Ile Ile Val Gly Ile Val Leu Ile Ile Tyr Phe Arg Lys 
                245                 250                 255     


Pro Cys Ser Gly Asp 
            260     


<210>  63
<211>  263
<212>  PRT
<213>  Homo sapiens

<400>  63

Met Ile Thr Phe Leu Pro Leu Leu Leu Gly Leu Ser Leu Gly Cys Thr 
1               5                   10                  15      


Gly Ala Gly Gly Phe Val Ala His Val Glu Ser Thr Cys Leu Leu Asp 
            20                  25                  30          


Asp Ala Gly Thr Pro Lys Asp Phe Thr Tyr Cys Ile Ser Phe Asn Lys 
        35                  40                  45              


Asp Leu Leu Thr Cys Trp Asp Pro Glu Glu Asn Lys Met Ala Pro Cys 
    50                  55                  60                  


Glu Phe Gly Val Leu Asn Ser Leu Ala Asn Val Leu Ser Gln His Leu 
65                  70                  75                  80  


Asn Gln Lys Asp Thr Leu Met Gln Arg Leu Arg Asn Gly Leu Gln Asn 
                85                  90                  95      


Cys Ala Thr His Thr Gln Pro Phe Trp Gly Ser Leu Thr Asn Arg Thr 
            100                 105                 110         


Arg Pro Pro Ser Val Gln Val Ala Lys Thr Thr Pro Phe Asn Thr Arg 
        115                 120                 125             


Glu Pro Val Met Leu Ala Cys Tyr Val Trp Gly Phe Tyr Pro Ala Glu 
    130                 135                 140                 


Val Thr Ile Thr Trp Arg Lys Asn Gly Lys Leu Val Met Pro His Ser 
145                 150                 155                 160 


Ser Ala His Lys Thr Ala Gln Pro Asn Gly Asp Trp Thr Tyr Gln Thr 
                165                 170                 175     


Leu Ser His Leu Ala Leu Thr Pro Ser Tyr Gly Asp Thr Tyr Thr Cys 
            180                 185                 190         


Val Val Glu His Thr Gly Ala Pro Glu Pro Ile Leu Arg Asp Trp Thr 
        195                 200                 205             


Pro Gly Leu Ser Pro Met Gln Thr Leu Lys Val Ser Val Ser Ala Val 
    210                 215                 220                 


Thr Leu Gly Leu Gly Leu Ile Ile Phe Ser Leu Gly Val Ile Ser Trp 
225                 230                 235                 240 


Arg Arg Ala Gly His Ser Ser Tyr Thr Pro Leu Pro Gly Ser Asn Tyr 
                245                 250                 255     


Ser Glu Gly Trp His Ile Ser 
            260             


<210>  64
<211>  250
<212>  PRT
<213>  Homo sapiens

<400>  64

Met Ala Leu Arg Ala Gly Leu Val Leu Gly Phe His Thr Leu Met Thr 
1               5                   10                  15      


Leu Leu Ser Pro Gln Glu Ala Gly Ala Thr Lys Ala Asp His Met Gly 
            20                  25                  30          


Ser Tyr Gly Pro Ala Phe Tyr Gln Ser Tyr Gly Ala Ser Gly Gln Phe 
        35                  40                  45              


Thr His Glu Phe Asp Glu Glu Gln Leu Phe Ser Val Asp Leu Lys Lys 
    50                  55                  60                  


Ser Glu Ala Val Trp Arg Leu Pro Glu Phe Gly Asp Phe Ala Arg Phe 
65                  70                  75                  80  


Asp Pro Gln Gly Gly Leu Ala Gly Ile Ala Ala Ile Lys Ala His Leu 
                85                  90                  95      


Asp Ile Leu Val Glu Arg Ser Asn Arg Ser Arg Ala Ile Asn Val Pro 
            100                 105                 110         


Pro Arg Val Thr Val Leu Pro Lys Ser Arg Val Glu Leu Gly Gln Pro 
        115                 120                 125             


Asn Ile Leu Ile Cys Ile Val Asp Asn Ile Phe Pro Pro Val Ile Asn 
    130                 135                 140                 


Ile Thr Trp Leu Arg Asn Gly Gln Thr Val Thr Glu Gly Val Ala Gln 
145                 150                 155                 160 


Thr Ser Phe Tyr Ser Gln Pro Asp His Leu Phe Arg Lys Phe His Tyr 
                165                 170                 175     


Leu Pro Phe Val Pro Ser Ala Glu Asp Val Tyr Asp Cys Gln Val Glu 
            180                 185                 190         


His Trp Gly Leu Asp Ala Pro Leu Leu Arg His Trp Glu Leu Gln Val 
        195                 200                 205             


Pro Ile Pro Pro Pro Asp Ala Met Glu Thr Leu Val Cys Ala Leu Gly 
    210                 215                 220                 


Leu Ala Ile Gly Leu Val Gly Phe Leu Val Gly Thr Val Leu Ile Ile 
225                 230                 235                 240 


Met Gly Thr Tyr Val Ser Ser Val Pro Arg 
                245                 250 


<210>  65
<211>  273
<212>  PRT
<213>  Homo sapiens

<400>  65

Met Gly Ser Gly Trp Val Pro Trp Val Val Ala Leu Leu Val Asn Leu 
1               5                   10                  15      


Thr Arg Leu Asp Ser Ser Met Thr Gln Gly Thr Asp Ser Pro Glu Asp 
            20                  25                  30          


Phe Val Ile Gln Ala Lys Ala Asp Cys Tyr Phe Thr Asn Gly Thr Glu 
        35                  40                  45              


Lys Val Gln Phe Val Val Arg Phe Ile Phe Asn Leu Glu Glu Tyr Val 
    50                  55                  60                  


Arg Phe Asp Ser Asp Val Gly Met Phe Val Ala Leu Thr Lys Leu Gly 
65                  70                  75                  80  


Gln Pro Asp Ala Glu Gln Trp Asn Ser Arg Leu Asp Leu Leu Glu Arg 
                85                  90                  95      


Ser Arg Gln Ala Val Asp Gly Val Cys Arg His Asn Tyr Arg Leu Gly 
            100                 105                 110         


Ala Pro Phe Thr Val Gly Arg Lys Val Gln Pro Glu Val Thr Val Tyr 
        115                 120                 125             


Pro Glu Arg Thr Pro Leu Leu His Gln His Asn Leu Leu His Cys Ser 
    130                 135                 140                 


Val Thr Gly Phe Tyr Pro Gly Asp Ile Lys Ile Lys Trp Phe Leu Asn 
145                 150                 155                 160 


Gly Gln Glu Glu Arg Ala Gly Val Met Ser Thr Gly Pro Ile Arg Asn 
                165                 170                 175     


Gly Asp Trp Thr Phe Gln Thr Val Val Met Leu Glu Met Thr Pro Glu 
            180                 185                 190         


Leu Gly His Val Tyr Thr Cys Leu Val Asp His Ser Ser Leu Leu Ser 
        195                 200                 205             


Pro Val Ser Val Glu Trp Arg Ala Gln Ser Glu Tyr Ser Trp Arg Lys 
    210                 215                 220                 


Met Leu Ser Gly Ile Ala Ala Phe Leu Leu Gly Leu Ile Phe Leu Leu 
225                 230                 235                 240 


Val Gly Ile Val Ile Gln Leu Arg Ala Gln Lys Gly Tyr Val Arg Thr 
                245                 250                 255     


Gln Met Ser Gly Asn Glu Val Ser Arg Ala Val Leu Leu Pro Gln Ser 
            260                 265                 270         


Cys 
    


<210>  66
<211>  260
<212>  PRT
<213>  Homo sapiens

<400>  66

Met Arg Pro Glu Asp Arg Met Phe His Ile Arg Ala Val Ile Leu Arg 
1               5                   10                  15      


Ala Leu Ser Leu Ala Phe Leu Leu Ser Leu Arg Gly Ala Gly Ala Ile 
            20                  25                  30          


Lys Ala Asp His Val Ser Thr Tyr Ala Ala Phe Val Gln Thr His Arg 
        35                  40                  45              


Pro Thr Gly Glu Phe Met Phe Glu Phe Asp Glu Asp Glu Met Phe Tyr 
    50                  55                  60                  


Val Asp Leu Asp Lys Lys Glu Thr Val Trp His Leu Glu Glu Phe Gly 
65                  70                  75                  80  


Gln Ala Phe Ser Phe Glu Ala Gln Gly Gly Leu Ala Asn Ile Ala Ile 
                85                  90                  95      


Leu Asn Asn Asn Leu Asn Thr Leu Ile Gln Arg Ser Asn His Thr Gln 
            100                 105                 110         


Ala Thr Asn Asp Pro Pro Glu Val Thr Val Phe Pro Lys Glu Pro Val 
        115                 120                 125             


Glu Leu Gly Gln Pro Asn Thr Leu Ile Cys His Ile Asp Lys Phe Phe 
    130                 135                 140                 


Pro Pro Val Leu Asn Val Thr Trp Leu Cys Asn Gly Glu Leu Val Thr 
145                 150                 155                 160 


Glu Gly Val Ala Glu Ser Leu Phe Leu Pro Arg Thr Asp Tyr Ser Phe 
                165                 170                 175     


His Lys Phe His Tyr Leu Thr Phe Val Pro Ser Ala Glu Asp Phe Tyr 
            180                 185                 190         


Asp Cys Arg Val Glu His Trp Gly Leu Asp Gln Pro Leu Leu Lys His 
        195                 200                 205             


Trp Glu Ala Gln Glu Pro Ile Gln Met Pro Glu Thr Thr Glu Thr Val 
    210                 215                 220                 


Leu Cys Ala Leu Gly Leu Val Leu Gly Leu Val Gly Ile Ile Val Gly 
225                 230                 235                 240 


Thr Val Leu Ile Ile Lys Ser Leu Arg Ser Gly His Asp Pro Arg Ala 
                245                 250                 255     


Gln Gly Thr Leu 
            260 


<210>  67
<211>  260
<212>  PRT
<213>  Homo sapiens

<400>  67

Met Arg Pro Glu Asp Arg Met Phe His Ile Arg Ala Val Ile Leu Arg 
1               5                   10                  15      


Ala Leu Ser Leu Ala Phe Leu Leu Ser Leu Arg Gly Ala Gly Ala Ile 
            20                  25                  30          


Lys Ala Asp His Val Ser Thr Tyr Ala Ala Phe Val Gln Thr His Arg 
        35                  40                  45              


Pro Thr Gly Glu Phe Met Phe Glu Phe Asp Glu Asp Glu Gln Phe Tyr 
    50                  55                  60                  


Val Asp Leu Asp Lys Lys Glu Thr Val Trp His Leu Glu Glu Phe Gly 
65                  70                  75                  80  


Arg Ala Phe Ser Phe Glu Ala Gln Gly Gly Leu Ala Asn Ile Ala Ile 
                85                  90                  95      


Leu Asn Asn Asn Leu Asn Thr Leu Ile Gln Arg Ser Asn His Thr Gln 
            100                 105                 110         


Ala Ala Asn Asp Pro Pro Glu Val Thr Val Phe Pro Lys Glu Pro Val 
        115                 120                 125             


Glu Leu Gly Gln Pro Asn Thr Leu Ile Cys His Ile Asp Arg Phe Phe 
    130                 135                 140                 


Pro Pro Val Leu Asn Val Thr Trp Leu Cys Asn Gly Glu Pro Val Thr 
145                 150                 155                 160 


Glu Gly Val Ala Glu Ser Leu Phe Leu Pro Arg Thr Asp Tyr Ser Phe 
                165                 170                 175     


His Lys Phe His Tyr Leu Thr Phe Val Pro Ser Ala Glu Asp Val Tyr 
            180                 185                 190         


Asp Cys Arg Val Glu His Trp Gly Leu Asp Gln Pro Leu Leu Lys His 
        195                 200                 205             


Trp Glu Ala Gln Glu Pro Ile Gln Met Pro Glu Thr Thr Glu Thr Val 
    210                 215                 220                 


Leu Cys Ala Leu Gly Leu Val Leu Gly Leu Val Gly Ile Ile Val Gly 
225                 230                 235                 240 


Thr Val Leu Ile Ile Lys Ser Leu Arg Ser Gly His Asp Pro Arg Ala 
                245                 250                 255     


Gln Gly Pro Leu 
            260 


<210>  68
<211>  258
<212>  PRT
<213>  Homo sapiens

<400>  68

Met Met Val Leu Gln Val Ser Ala Ala Pro Arg Thr Val Ala Leu Thr 
1               5                   10                  15      


Ala Leu Leu Met Val Leu Leu Thr Ser Val Val Gln Gly Arg Ala Thr 
            20                  25                  30          


Pro Glu Asn Tyr Val Tyr Gln Gly Arg Gln Glu Cys Tyr Ala Phe Asn 
        35                  40                  45              


Gly Thr Gln Arg Phe Leu Glu Arg Tyr Ile Tyr Asn Arg Glu Glu Tyr 
    50                  55                  60                  


Ala Arg Phe Asp Ser Asp Val Gly Glu Phe Arg Ala Val Thr Glu Leu 
65                  70                  75                  80  


Gly Arg Pro Ala Ala Glu Tyr Trp Asn Ser Gln Lys Asp Ile Leu Glu 
                85                  90                  95      


Glu Lys Arg Ala Val Pro Asp Arg Val Cys Arg His Asn Tyr Glu Leu 
            100                 105                 110         


Asp Glu Ala Val Thr Leu Gln Arg Arg Val Gln Pro Lys Val Asn Val 
        115                 120                 125             


Ser Pro Ser Lys Lys Gly Pro Leu Gln His His Asn Leu Leu Val Cys 
    130                 135                 140                 


His Val Thr Asp Phe Tyr Pro Gly Ser Ile Gln Val Arg Trp Phe Leu 
145                 150                 155                 160 


Asn Gly Gln Glu Glu Thr Ala Gly Val Val Ser Thr Asn Leu Ile Arg 
                165                 170                 175     


Asn Gly Asp Trp Thr Phe Gln Ile Leu Val Met Leu Glu Met Thr Pro 
            180                 185                 190         


Gln Gln Gly Asp Val Tyr Ile Cys Gln Val Glu His Thr Ser Leu Asp 
        195                 200                 205             


Ser Pro Val Thr Val Glu Trp Lys Ala Gln Ser Asp Ser Ala Gln Ser 
    210                 215                 220                 


Lys Thr Leu Thr Gly Ala Gly Gly Phe Val Leu Gly Leu Ile Ile Cys 
225                 230                 235                 240 


Gly Val Gly Ile Phe Met His Arg Arg Ser Lys Lys Val Gln Arg Gly 
                245                 250                 255     


Ser Ala 
        


<210>  69
<211>  258
<212>  PRT
<213>  Homo sapiens

<400>  69

Met Met Val Leu Gln Val Ser Ala Ala Pro Arg Thr Val Ala Leu Thr 
1               5                   10                  15      


Ala Leu Leu Met Val Leu Leu Thr Ser Val Val Gln Gly Arg Ala Thr 
            20                  25                  30          


Pro Glu Asn Tyr Leu Phe Gln Gly Arg Gln Glu Cys Tyr Ala Phe Asn 
        35                  40                  45              


Gly Thr Gln Arg Phe Leu Glu Arg Tyr Ile Tyr Asn Arg Glu Glu Phe 
    50                  55                  60                  


Val Arg Phe Asp Ser Asp Val Gly Glu Phe Arg Ala Val Thr Glu Leu 
65                  70                  75                  80  


Gly Arg Pro Asp Glu Glu Tyr Trp Asn Ser Gln Lys Asp Ile Leu Glu 
                85                  90                  95      


Glu Glu Arg Ala Val Pro Asp Arg Met Cys Arg His Asn Tyr Glu Leu 
            100                 105                 110         


Gly Gly Pro Met Thr Leu Gln Arg Arg Val Gln Pro Arg Val Asn Val 
        115                 120                 125             


Ser Pro Ser Lys Lys Gly Pro Leu Gln His His Asn Leu Leu Val Cys 
    130                 135                 140                 


His Val Thr Asp Phe Tyr Pro Gly Ser Ile Gln Val Arg Trp Phe Leu 
145                 150                 155                 160 


Asn Gly Gln Glu Glu Thr Ala Gly Val Val Ser Thr Asn Leu Ile Arg 
                165                 170                 175     


Asn Gly Asp Trp Thr Phe Gln Ile Leu Val Met Leu Glu Met Thr Pro 
            180                 185                 190         


Gln Gln Gly Asp Val Tyr Thr Cys Gln Val Glu His Thr Ser Leu Asp 
        195                 200                 205             


Ser Pro Val Thr Val Glu Trp Lys Ala Gln Ser Asp Ser Ala Arg Ser 
    210                 215                 220                 


Lys Thr Leu Thr Gly Ala Gly Gly Phe Val Leu Gly Leu Ile Ile Cys 
225                 230                 235                 240 


Gly Val Gly Ile Phe Met His Arg Arg Ser Lys Lys Val Gln Arg Gly 
                245                 250                 255     


Ser Ala 
        


<210>  70
<211>  258
<212>  PRT
<213>  Homo sapiens

<400>  70

Met Met Val Leu Gln Val Ser Ala Ala Pro Arg Thr Val Ala Leu Thr 
1               5                   10                  15      


Ala Leu Leu Met Val Leu Leu Thr Ser Val Val Gln Gly Arg Ala Thr 
            20                  25                  30          


Pro Glu Asn Tyr Val Tyr Gln Leu Arg Gln Glu Cys Tyr Ala Phe Asn 
        35                  40                  45              


Gly Thr Gln Arg Phe Leu Glu Arg Tyr Ile Tyr Asn Arg Glu Glu Phe 
    50                  55                  60                  


Val Arg Phe Asp Ser Asp Val Gly Glu Phe Arg Ala Val Thr Glu Leu 
65                  70                  75                  80  


Gly Arg Pro Asp Glu Asp Tyr Trp Asn Ser Gln Lys Asp Leu Leu Glu 
                85                  90                  95      


Glu Lys Arg Ala Val Pro Asp Arg Val Cys Arg His Asn Tyr Glu Leu 
            100                 105                 110         


Asp Glu Ala Val Thr Leu Gln Arg Arg Val Gln Pro Lys Val Asn Val 
        115                 120                 125             


Ser Pro Ser Lys Lys Gly Pro Leu Gln His His Asn Leu Leu Val Cys 
    130                 135                 140                 


His Val Thr Asp Phe Tyr Pro Gly Ser Ile Gln Val Arg Trp Phe Leu 
145                 150                 155                 160 


Asn Gly Gln Glu Glu Thr Ala Gly Val Val Ser Thr Asn Leu Ile Arg 
                165                 170                 175     


Asn Gly Asp Trp Thr Phe Gln Ile Leu Val Met Leu Glu Met Thr Pro 
            180                 185                 190         


Gln Gln Gly Asp Val Tyr Ile Cys Gln Val Glu His Thr Ser Leu Asp 
        195                 200                 205             


Ser Pro Val Thr Val Glu Trp Lys Ala Gln Ser Asp Ser Ala Arg Ser 
    210                 215                 220                 


Lys Thr Leu Thr Gly Ala Gly Gly Phe Val Leu Gly Leu Ile Ile Cys 
225                 230                 235                 240 


Gly Val Gly Ile Phe Met His Arg Arg Ser Lys Lys Val Gln Arg Gly 
                245                 250                 255     


Ser Ala 
        


<210>  71
<211>  258
<212>  PRT
<213>  Homo sapiens

<400>  71

Met Met Val Leu Gln Val Ser Ala Ala Pro Arg Thr Val Ala Leu Thr 
1               5                   10                  15      


Ala Leu Leu Met Val Leu Leu Thr Ser Val Val Gln Gly Arg Ala Thr 
            20                  25                  30          


Pro Glu Asn Tyr Leu Phe Gln Gly Arg Gln Glu Cys Tyr Ala Phe Asn 
        35                  40                  45              


Gly Thr Gln Arg Phe Leu Glu Arg Tyr Ile Tyr Asn Arg Glu Glu Phe 
    50                  55                  60                  


Ala Arg Phe Asp Ser Asp Val Gly Glu Phe Arg Ala Val Thr Glu Leu 
65                  70                  75                  80  


Gly Arg Pro Ala Ala Glu Tyr Trp Asn Ser Gln Lys Asp Ile Leu Glu 
                85                  90                  95      


Glu Lys Arg Ala Val Pro Asp Arg Met Cys Arg His Asn Tyr Glu Leu 
            100                 105                 110         


Gly Gly Pro Met Thr Leu Gln Arg Arg Val Gln Pro Arg Val Asn Val 
        115                 120                 125             


Ser Pro Ser Lys Lys Gly Pro Leu Gln His His Asn Leu Leu Val Cys 
    130                 135                 140                 


His Val Thr Asp Phe Tyr Pro Gly Ser Ile Gln Val Arg Trp Phe Leu 
145                 150                 155                 160 


Asn Gly Gln Glu Glu Thr Ala Gly Val Val Ser Thr Asn Leu Ile Arg 
                165                 170                 175     


Asn Gly Asp Trp Thr Phe Gln Ile Leu Val Met Leu Glu Met Thr Pro 
            180                 185                 190         


Gln Gln Gly Asp Val Tyr Thr Cys Gln Val Glu His Thr Ser Leu Asp 
        195                 200                 205             


Ser Pro Val Thr Val Glu Trp Lys Ala Gln Ser Asp Ser Ala Arg Ser 
    210                 215                 220                 


Lys Thr Leu Thr Gly Ala Gly Gly Phe Val Leu Gly Leu Ile Ile Cys 
225                 230                 235                 240 


Gly Val Gly Ile Phe Met His Arg Arg Ser Lys Lys Val Gln Arg Gly 
                245                 250                 255     


Ser Ala 
        


<210>  72
<211>  258
<212>  PRT
<213>  Homo sapiens

<400>  72

Met Met Val Leu Gln Val Ser Ala Ala Pro Arg Thr Val Ala Leu Thr 
1               5                   10                  15      


Ala Leu Leu Met Val Leu Leu Thr Ser Val Val Gln Gly Arg Ala Thr 
            20                  25                  30          


Pro Glu Asn Tyr Val Tyr Gln Leu Arg Gln Glu Cys Tyr Ala Phe Asn 
        35                  40                  45              


Gly Thr Gln Arg Phe Leu Glu Arg Tyr Ile Tyr Asn Arg Glu Glu Phe 
    50                  55                  60                  


Val Arg Phe Asp Ser Asp Val Gly Glu Phe Arg Ala Val Thr Glu Leu 
65                  70                  75                  80  


Gly Arg Pro Asp Glu Asp Tyr Trp Asn Ser Gln Lys Asp Leu Leu Glu 
                85                  90                  95      


Glu Glu Arg Ala Val Pro Asp Arg Met Cys Arg His Asn Tyr Glu Leu 
            100                 105                 110         


Asp Glu Ala Val Thr Leu Gln Arg Arg Val Gln Pro Lys Val Asn Val 
        115                 120                 125             


Ser Pro Ser Lys Lys Gly Pro Leu Gln His His Asn Leu Leu Val Cys 
    130                 135                 140                 


His Val Thr Asp Phe Tyr Pro Gly Ser Ile Gln Val Arg Trp Phe Leu 
145                 150                 155                 160 


Asn Gly Gln Glu Glu Thr Ala Gly Val Val Ser Thr Asn Leu Ile Arg 
                165                 170                 175     


Asn Gly Asp Trp Thr Phe Gln Ile Leu Val Met Leu Glu Met Thr Pro 
            180                 185                 190         


Gln Gln Gly Asp Val Tyr Ile Cys Gln Val Glu His Thr Ser Leu Asp 
        195                 200                 205             


Ser Pro Val Thr Val Glu Trp Lys Ala Gln Ser Asp Ser Ala Arg Ser 
    210                 215                 220                 


Lys Thr Leu Thr Gly Ala Gly Gly Phe Val Leu Gly Leu Ile Ile Cys 
225                 230                 235                 240 


Gly Val Gly Ile Phe Met His Arg Arg Ser Lys Lys Val Gln Arg Gly 
                245                 250                 255     


Ser Ala 
        


<210>  73
<211>  258
<212>  PRT
<213>  Homo sapiens

<400>  73

Met Met Val Leu Gln Val Ser Ala Ala Pro Arg Thr Val Ala Leu Thr 
1               5                   10                  15      


Ala Leu Leu Met Val Leu Leu Thr Ser Val Val Gln Gly Arg Ala Thr 
            20                  25                  30          


Pro Glu Asn Tyr Val His Gln Leu Arg Gln Glu Cys Tyr Ala Phe Asn 
        35                  40                  45              


Gly Thr Gln Arg Phe Leu Glu Arg Tyr Ile Tyr Asn Arg Glu Glu Phe 
    50                  55                  60                  


Val Arg Phe Asp Ser Asp Val Gly Glu Phe Arg Ala Val Thr Glu Leu 
65                  70                  75                  80  


Gly Arg Pro Asp Glu Asp Tyr Trp Asn Ser Gln Lys Asp Ile Leu Glu 
                85                  90                  95      


Glu Glu Arg Ala Val Pro Asp Arg Val Cys Arg His Asn Tyr Glu Leu 
            100                 105                 110         


Asp Glu Ala Val Thr Leu Gln Arg Arg Val Gln Pro Lys Val Asn Val 
        115                 120                 125             


Ser Pro Ser Lys Lys Gly Pro Leu Gln His His Asn Leu Leu Val Cys 
    130                 135                 140                 


His Val Thr Asp Phe Tyr Pro Gly Ser Ile Gln Val Arg Trp Phe Leu 
145                 150                 155                 160 


Asn Gly Gln Glu Glu Thr Ala Gly Val Val Ser Thr Asn Leu Ile Arg 
                165                 170                 175     


Asn Gly Asp Trp Thr Phe Gln Ile Leu Val Met Leu Glu Met Thr Pro 
            180                 185                 190         


Gln Gln Gly Asp Val Tyr Ile Cys Gln Val Glu His Thr Ser Leu Asp 
        195                 200                 205             


Ser Pro Val Thr Val Glu Trp Lys Ala Gln Ser Asp Ser Ala Arg Ser 
    210                 215                 220                 


Lys Thr Leu Thr Gly Ala Gly Gly Phe Val Leu Gly Leu Ile Ile Cys 
225                 230                 235                 240 


Gly Val Gly Ile Phe Met His Arg Arg Ser Lys Lys Val Gln Arg Gly 
                245                 250                 255     


Ser Ala 
        


<210>  74
<211>  258
<212>  PRT
<213>  Homo sapiens

<400>  74

Met Met Val Leu Gln Val Ser Ala Ala Pro Arg Thr Val Ala Leu Thr 
1               5                   10                  15      


Ala Leu Leu Met Val Leu Leu Thr Ser Val Val Gln Gly Arg Ala Thr 
            20                  25                  30          


Pro Glu Asn Tyr Val Tyr Gln Leu Arg Gln Glu Cys Tyr Ala Phe Asn 
        35                  40                  45              


Gly Thr Gln Arg Phe Leu Glu Arg Tyr Ile Tyr Asn Arg Gln Glu Tyr 
    50                  55                  60                  


Ala Arg Phe Asp Ser Asp Val Gly Glu Phe Arg Ala Val Thr Glu Leu 
65                  70                  75                  80  


Gly Arg Pro Ala Ala Glu Tyr Trp Asn Ser Gln Lys Asp Leu Leu Glu 
                85                  90                  95      


Glu Arg Arg Ala Val Pro Asp Arg Met Cys Arg His Asn Tyr Glu Leu 
            100                 105                 110         


Asp Glu Ala Val Thr Leu Gln Arg Arg Val Gln Pro Lys Val Asn Val 
        115                 120                 125             


Ser Pro Ser Lys Lys Gly Pro Leu Gln His His Asn Leu Leu Val Cys 
    130                 135                 140                 


His Val Thr Asp Phe Tyr Pro Gly Ser Ile Gln Val Arg Trp Phe Leu 
145                 150                 155                 160 


Asn Gly Gln Glu Glu Thr Ala Gly Val Val Ser Thr Asn Leu Ile Arg 
                165                 170                 175     


Asn Gly Asp Trp Thr Phe Gln Ile Leu Val Met Leu Glu Met Thr Pro 
            180                 185                 190         


Gln Gln Gly Asp Val Tyr Ile Cys Gln Val Glu His Thr Ser Leu Asp 
        195                 200                 205             


Ser Pro Val Thr Val Glu Trp Lys Ala Gln Ser Asp Ser Ala Arg Ser 
    210                 215                 220                 


Lys Thr Leu Thr Gly Ala Gly Gly Phe Val Leu Gly Leu Ile Ile Cys 
225                 230                 235                 240 


Gly Val Gly Ile Phe Met His Arg Arg Ser Lys Lys Val Gln Arg Gly 
                245                 250                 255     


Ser Ala 
        


<210>  75
<211>  258
<212>  PRT
<213>  Homo sapiens

<400>  75

Met Met Val Leu Gln Val Ser Ala Ala Pro Arg Thr Val Ala Leu Thr 
1               5                   10                  15      


Ala Leu Leu Met Val Leu Leu Thr Ser Val Val Gln Gly Arg Ala Thr 
            20                  25                  30          


Pro Glu Asn Tyr Val Tyr Gln Leu Arg Gln Glu Cys Tyr Ala Phe Asn 
        35                  40                  45              


Gly Thr Gln Arg Phe Leu Glu Arg Tyr Ile Tyr Asn Arg Glu Glu Tyr 
    50                  55                  60                  


Ala Arg Phe Asp Ser Asp Val Gly Glu Phe Arg Ala Val Thr Glu Leu 
65                  70                  75                  80  


Gly Arg Pro Ala Ala Glu Tyr Trp Asn Ser Gln Lys Asp Ile Leu Glu 
                85                  90                  95      


Glu Glu Arg Ala Val Pro Asp Arg Ile Cys Arg His Asn Tyr Glu Leu 
            100                 105                 110         


Asp Glu Ala Val Thr Leu Gln Arg Arg Val Gln Pro Lys Val Asn Val 
        115                 120                 125             


Ser Pro Ser Lys Lys Gly Pro Leu Gln His His Asn Leu Leu Val Cys 
    130                 135                 140                 


His Val Thr Asp Phe Tyr Pro Gly Ser Ile Gln Val Arg Trp Phe Leu 
145                 150                 155                 160 


Asn Gly Gln Glu Glu Thr Ala Gly Val Val Ser Thr Asn Leu Ile Arg 
                165                 170                 175     


Asn Gly Asp Trp Thr Phe Gln Ile Leu Val Met Leu Glu Met Thr Pro 
            180                 185                 190         


Gln Gln Gly Asp Val Tyr Ile Cys Gln Val Glu His Thr Ser Leu Asp 
        195                 200                 205             


Ser Pro Val Thr Val Glu Trp Lys Ala Gln Ser Asp Ser Ala Arg Ser 
    210                 215                 220                 


Lys Thr Leu Thr Gly Ala Gly Gly Phe Val Leu Gly Leu Ile Ile Cys 
225                 230                 235                 240 


Gly Val Gly Ile Phe Met His Arg Arg Ser Lys Lys Val Gln Arg Gly 
                245                 250                 255     


Ser Ala 
        


<210>  76
<211>  258
<212>  PRT
<213>  Homo sapiens

<400>  76

Met Met Val Leu Gln Val Ser Ala Ala Pro Arg Thr Val Ala Leu Thr 
1               5                   10                  15      


Ala Leu Leu Met Val Leu Leu Thr Ser Val Val Gln Gly Arg Ala Thr 
            20                  25                  30          


Pro Glu Asn Tyr Val His Gln Leu Arg Gln Glu Cys Tyr Ala Phe Asn 
        35                  40                  45              


Gly Thr Gln Arg Phe Leu Glu Arg Tyr Ile Tyr Asn Arg Glu Glu Phe 
    50                  55                  60                  


Val Arg Phe Asp Ser Asp Val Gly Glu Phe Arg Ala Val Thr Glu Leu 
65                  70                  75                  80  


Gly Arg Pro Asp Glu Asp Tyr Trp Asn Ser Gln Lys Asp Ile Leu Glu 
                85                  90                  95      


Glu Lys Arg Ala Val Pro Asp Arg Val Cys Arg His Asn Tyr Glu Leu 
            100                 105                 110         


Asp Glu Ala Val Thr Leu Gln Arg Arg Val Gln Pro Lys Val Asn Val 
        115                 120                 125             


Ser Pro Ser Lys Lys Gly Pro Leu Gln His His Asn Leu Leu Val Cys 
    130                 135                 140                 


His Val Thr Asp Phe Tyr Pro Gly Ser Ile Gln Val Arg Trp Phe Leu 
145                 150                 155                 160 


Asn Gly Gln Glu Glu Thr Ala Gly Val Val Ser Thr Asn Leu Ile Arg 
                165                 170                 175     


Asn Gly Asp Trp Thr Phe Gln Ile Leu Val Met Leu Glu Met Thr Pro 
            180                 185                 190         


Gln Gln Gly Asp Val Tyr Ile Cys Gln Val Glu His Thr Ser Leu Asp 
        195                 200                 205             


Ser Pro Val Thr Val Glu Trp Lys Ala Gln Ser Asp Ser Ala Arg Ser 
    210                 215                 220                 


Lys Thr Leu Thr Gly Ala Gly Gly Phe Val Leu Gly Leu Ile Ile Cys 
225                 230                 235                 240 


Gly Val Gly Ile Phe Met His Arg Arg Ser Lys Lys Val Gln Arg Gly 
                245                 250                 255     


Ser Ala 
        


<210>  77
<211>  258
<212>  PRT
<213>  Homo sapiens

<400>  77

Met Met Val Leu Gln Val Ser Ala Ala Pro Arg Thr Val Ala Leu Thr 
1               5                   10                  15      


Ala Leu Leu Met Val Leu Leu Thr Ser Val Val Gln Gly Arg Ala Thr 
            20                  25                  30          


Pro Glu Asn Tyr Leu Phe Gln Gly Arg Gln Glu Cys Tyr Ala Phe Asn 
        35                  40                  45              


Gly Thr Gln Arg Phe Leu Glu Arg Tyr Ile Tyr Asn Arg Glu Glu Phe 
    50                  55                  60                  


Val Arg Phe Asp Ser Asp Val Gly Glu Phe Arg Ala Val Thr Glu Leu 
65                  70                  75                  80  


Gly Arg Pro Ala Ala Glu Tyr Trp Asn Ser Gln Lys Asp Ile Leu Glu 
                85                  90                  95      


Glu Glu Arg Ala Val Pro Asp Arg Met Cys Arg His Asn Tyr Glu Leu 
            100                 105                 110         


Gly Gly Pro Met Thr Leu Gln Arg Arg Val Gln Pro Arg Val Asn Val 
        115                 120                 125             


Ser Pro Ser Lys Lys Gly Pro Leu Gln His His Asn Leu Leu Val Cys 
    130                 135                 140                 


His Val Thr Asp Phe Tyr Pro Gly Ser Ile Gln Val Arg Trp Phe Leu 
145                 150                 155                 160 


Asn Gly Gln Glu Glu Thr Ala Gly Val Val Ser Thr Asn Leu Ile Arg 
                165                 170                 175     


Asn Gly Asp Trp Thr Phe Gln Ile Leu Val Met Leu Glu Met Thr Pro 
            180                 185                 190         


Gln Gln Gly Asp Val Tyr Thr Cys Gln Val Glu His Thr Ser Leu Asp 
        195                 200                 205             


Ser Pro Val Thr Val Glu Trp Lys Ala Gln Ser Asp Ser Ala Arg Ser 
    210                 215                 220                 


Lys Thr Leu Thr Gly Ala Gly Gly Phe Val Leu Gly Leu Ile Ile Cys 
225                 230                 235                 240 


Gly Val Gly Ile Phe Met His Arg Arg Ser Lys Lys Val Gln Arg Gly 
                245                 250                 255     


Ser Ala 
        


<210>  78
<211>  258
<212>  PRT
<213>  Homo sapiens

<400>  78

Met Met Val Leu Gln Val Ser Ala Ala Pro Arg Thr Val Ala Leu Thr 
1               5                   10                  15      


Ala Leu Leu Met Val Leu Leu Thr Ser Val Val Gln Gly Arg Ala Thr 
            20                  25                  30          


Pro Glu Asn Tyr Val Tyr Gln Leu Arg Gln Glu Cys Tyr Ala Phe Asn 
        35                  40                  45              


Gly Thr Gln Arg Phe Leu Glu Arg Tyr Ile Tyr Asn Arg Glu Glu Phe 
    50                  55                  60                  


Val Arg Phe Asp Ser Asp Val Gly Glu Phe Arg Ala Val Thr Glu Leu 
65                  70                  75                  80  


Gly Arg Pro Asp Glu Asp Tyr Trp Asn Ser Gln Lys Asp Leu Leu Glu 
                85                  90                  95      


Glu Lys Arg Ala Val Pro Asp Arg Val Cys Arg His Asn Tyr Glu Leu 
            100                 105                 110         


Asp Glu Ala Val Thr Leu Gln Arg Arg Val Gln Pro Lys Val Asn Val 
        115                 120                 125             


Ser Pro Ser Lys Lys Gly Pro Leu Gln His His Asn Leu Leu Val Cys 
    130                 135                 140                 


His Val Thr Asp Phe Tyr Pro Gly Ser Ile Gln Val Arg Trp Phe Leu 
145                 150                 155                 160 


Asn Gly Gln Glu Glu Thr Ala Gly Val Val Ser Thr Asn Leu Ile Arg 
                165                 170                 175     


Asn Gly Asp Trp Thr Phe Gln Ile Leu Val Met Leu Glu Met Thr Pro 
            180                 185                 190         


Gln Gln Gly Asp Val Tyr Ile Cys Gln Val Glu His Thr Ser Leu Asp 
        195                 200                 205             


Ser Pro Val Thr Val Glu Trp Lys Ala Gln Ser Asp Ser Ala Arg Ser 
    210                 215                 220                 


Lys Thr Leu Thr Gly Ala Gly Gly Phe Met Leu Gly Leu Ile Ile Cys 
225                 230                 235                 240 


Gly Val Gly Ile Phe Met His Arg Arg Ser Lys Lys Val Gln Arg Gly 
                245                 250                 255     


Ser Ala 
        


<210>  79
<211>  258
<212>  PRT
<213>  Homo sapiens

<400>  79

Met Met Val Leu Gln Val Ser Ala Ala Pro Arg Thr Val Ala Leu Thr 
1               5                   10                  15      


Ala Leu Leu Met Val Leu Leu Thr Ser Val Val Gln Gly Arg Ala Thr 
            20                  25                  30          


Pro Glu Asn Tyr Leu Phe Gln Gly Arg Gln Glu Cys Tyr Ala Phe Asn 
        35                  40                  45              


Gly Thr Gln Arg Phe Leu Glu Arg Tyr Ile Tyr Asn Arg Glu Glu Phe 
    50                  55                  60                  


Val Arg Phe Asp Ser Asp Val Gly Glu Phe Arg Ala Val Thr Glu Leu 
65                  70                  75                  80  


Gly Arg Pro Asp Glu Glu Tyr Trp Asn Ser Gln Lys Asp Ile Leu Glu 
                85                  90                  95      


Glu Glu Arg Ala Val Pro Asp Arg Met Cys Arg His Asn Tyr Glu Leu 
            100                 105                 110         


Gly Gly Pro Met Thr Leu Gln Arg Arg Val Gln Pro Arg Val Asn Val 
        115                 120                 125             


Ser Pro Ser Lys Lys Gly Pro Leu Gln His His Asn Leu Leu Val Cys 
    130                 135                 140                 


His Val Thr Asp Phe Tyr Pro Gly Ser Ile Gln Val Gln Trp Phe Leu 
145                 150                 155                 160 


Asn Gly Gln Glu Glu Thr Ala Gly Val Val Ser Thr Asn Leu Ile Arg 
                165                 170                 175     


Asn Gly Asp Trp Thr Phe Gln Ile Leu Val Met Leu Glu Met Thr Pro 
            180                 185                 190         


Gln Gln Gly Asp Val Tyr Thr Cys Gln Val Glu His Thr Ser Leu Asp 
        195                 200                 205             


Ser Pro Val Thr Val Glu Trp Lys Ala Gln Ser Asp Ser Ala Arg Ser 
    210                 215                 220                 


Lys Thr Leu Thr Gly Ala Gly Gly Phe Val Leu Gly Leu Ile Ile Cys 
225                 230                 235                 240 


Gly Val Gly Ile Phe Met His Arg Arg Ser Lys Lys Val Gln Arg Gly 
                245                 250                 255     


Ser Ala 
        


<210>  80
<211>  255
<212>  PRT
<213>  Homo sapiens

<400>  80

Met Ile Leu Asn Lys Ala Leu Leu Leu Gly Ala Leu Ala Leu Thr Thr 
1               5                   10                  15      


Val Met Ser Pro Cys Gly Gly Glu Asp Ile Val Ala Asp His Val Ala 
            20                  25                  30          


Ser Cys Gly Val Asn Leu Tyr Gln Phe Tyr Gly Pro Ser Gly Gln Tyr 
        35                  40                  45              


Thr His Glu Phe Asp Gly Asp Glu Glu Phe Tyr Val Asp Leu Glu Arg 
    50                  55                  60                  


Lys Glu Thr Ala Trp Arg Trp Pro Glu Phe Ser Lys Phe Gly Gly Phe 
65                  70                  75                  80  


Asp Pro Gln Gly Ala Leu Arg Asn Met Ala Val Ala Lys His Asn Leu 
                85                  90                  95      


Asn Ile Met Ile Lys Arg Tyr Asn Ser Thr Ala Ala Thr Asn Glu Val 
            100                 105                 110         


Pro Glu Val Thr Val Phe Ser Lys Ser Pro Val Thr Leu Gly Gln Pro 
        115                 120                 125             


Asn Thr Leu Ile Cys Leu Val Asp Asn Ile Phe Pro Pro Val Val Asn 
    130                 135                 140                 


Ile Thr Trp Leu Ser Asn Gly Gln Ser Val Thr Glu Gly Val Ser Glu 
145                 150                 155                 160 


Thr Ser Phe Leu Ser Lys Ser Asp His Ser Phe Phe Lys Ile Ser Tyr 
                165                 170                 175     


Leu Thr Phe Leu Pro Ser Ala Asp Glu Ile Tyr Asp Cys Lys Val Glu 
            180                 185                 190         


His Trp Gly Leu Asp Gln Pro Leu Leu Lys His Trp Glu Pro Glu Ile 
        195                 200                 205             


Pro Ala Pro Met Ser Glu Leu Thr Glu Thr Val Val Cys Ala Leu Gly 
    210                 215                 220                 


Leu Ser Val Gly Leu Val Gly Ile Val Val Gly Thr Val Phe Ile Ile 
225                 230                 235                 240 


Gln Gly Leu Arg Ser Val Gly Ala Ser Arg His Gln Gly Pro Leu 
                245                 250                 255 


<210>  81
<211>  255
<212>  PRT
<213>  Homo sapiens

<400>  81

Met Ile Leu Asn Lys Ala Leu Leu Leu Gly Ala Leu Ala Leu Thr Thr 
1               5                   10                  15      


Val Met Ser Pro Cys Gly Gly Glu Asp Ile Val Ala Asp His Val Ala 
            20                  25                  30          


Ser Cys Gly Val Asn Leu Tyr Gln Phe Tyr Gly Pro Ser Gly Gln Tyr 
        35                  40                  45              


Thr His Glu Phe Asp Gly Asp Glu Gln Phe Tyr Val Asp Leu Glu Arg 
    50                  55                  60                  


Lys Glu Thr Ala Trp Arg Trp Pro Glu Phe Ser Lys Phe Gly Gly Phe 
65                  70                  75                  80  


Asp Pro Gln Gly Ala Leu Arg Asn Met Ala Val Ala Lys His Asn Leu 
                85                  90                  95      


Asn Ile Met Ile Lys Arg Tyr Asn Ser Thr Ala Ala Thr Asn Glu Val 
            100                 105                 110         


Pro Glu Val Thr Val Phe Ser Lys Ser Pro Val Thr Leu Gly Gln Pro 
        115                 120                 125             


Asn Thr Leu Ile Cys Leu Val Asp Asn Ile Phe Pro Pro Val Val Asn 
    130                 135                 140                 


Ile Thr Trp Leu Ser Asn Gly Gln Ser Val Thr Glu Gly Val Ser Glu 
145                 150                 155                 160 


Thr Ser Phe Leu Ser Lys Ser Asp His Ser Phe Phe Lys Ile Ser Tyr 
                165                 170                 175     


Leu Thr Phe Leu Pro Ser Ala Asp Glu Ile Tyr Asp Cys Lys Val Glu 
            180                 185                 190         


His Trp Gly Leu Asp Gln Pro Leu Leu Lys His Trp Glu Pro Glu Ile 
        195                 200                 205             


Pro Ala Pro Met Ser Glu Leu Thr Glu Thr Val Val Cys Ala Leu Gly 
    210                 215                 220                 


Leu Ser Val Gly Leu Met Gly Ile Val Val Gly Thr Val Phe Ile Ile 
225                 230                 235                 240 


Gln Gly Leu Arg Ser Val Gly Ala Ser Arg His Gln Gly Pro Leu 
                245                 250                 255 


<210>  82
<211>  255
<212>  PRT
<213>  Homo sapiens

<400>  82

Met Ile Leu Asn Lys Ala Leu Leu Leu Gly Ala Leu Ala Leu Thr Thr 
1               5                   10                  15      


Val Met Ser Pro Cys Gly Gly Glu Asp Ile Val Ala Asp His Val Ala 
            20                  25                  30          


Ser Cys Gly Val Asn Leu Tyr Gln Phe Tyr Gly Pro Ser Gly Gln Phe 
        35                  40                  45              


Thr His Glu Phe Asp Gly Asp Glu Gln Phe Tyr Val Asp Leu Glu Lys 
    50                  55                  60                  


Lys Glu Thr Ala Trp Arg Trp Pro Glu Phe Ser Lys Phe Gly Gly Phe 
65                  70                  75                  80  


Asp Pro Gln Gly Ala Leu Arg Asn Met Ala Val Ala Lys His Asn Leu 
                85                  90                  95      


Asn Ile Met Ile Lys Arg Tyr Asn Ser Thr Ala Ala Thr Asn Glu Val 
            100                 105                 110         


Pro Glu Val Thr Val Phe Ser Lys Ser Pro Val Thr Leu Gly Gln Pro 
        115                 120                 125             


Asn Thr Leu Ile Cys Leu Val Asp Asn Ile Phe Pro Pro Val Val Asn 
    130                 135                 140                 


Ile Thr Trp Leu Ser Asn Gly His Ala Val Thr Glu Gly Val Ser Glu 
145                 150                 155                 160 


Thr Ser Phe Leu Ser Lys Ser Asp His Ser Phe Phe Lys Ile Ser Tyr 
                165                 170                 175     


Leu Thr Phe Leu Pro Ser Ala Asp Glu Ile Tyr Asp Cys Lys Val Glu 
            180                 185                 190         


His Trp Gly Leu Asp Gln Pro Leu Leu Lys His Trp Glu Pro Glu Ile 
        195                 200                 205             


Pro Ala Pro Met Ser Glu Leu Thr Glu Thr Val Val Cys Ala Leu Gly 
    210                 215                 220                 


Leu Ser Val Gly Leu Val Gly Ile Val Val Gly Thr Val Phe Ile Ile 
225                 230                 235                 240 


Gln Gly Leu Arg Ser Val Gly Ala Ser Arg His Gln Gly Pro Leu 
                245                 250                 255 


<210>  83
<211>  255
<212>  PRT
<213>  Homo sapiens

<400>  83

Met Ile Leu Asn Lys Ala Leu Leu Leu Gly Ala Leu Ala Leu Thr Thr 
1               5                   10                  15      


Met Met Ser Pro Cys Gly Gly Glu Gly Ile Val Ala Asp His Val Ala 
            20                  25                  30          


Ser Cys Gly Val Asn Leu Tyr Gln Phe Tyr Gly Pro Ser Gly Gln Tyr 
        35                  40                  45              


Thr His Glu Phe Asp Gly Asp Glu Glu Phe Tyr Val Asp Leu Glu Arg 
    50                  55                  60                  


Lys Glu Thr Ala Trp Arg Trp Pro Glu Phe Ser Lys Phe Gly Gly Phe 
65                  70                  75                  80  


Asp Pro Gln Gly Ala Leu Arg Asn Met Ala Val Ala Lys His Asn Leu 
                85                  90                  95      


Asn Ile Met Ile Lys Arg Tyr Asn Ser Thr Ala Ala Thr Asn Glu Val 
            100                 105                 110         


Pro Glu Val Thr Val Phe Ser Lys Ser Pro Val Thr Leu Gly Gln Pro 
        115                 120                 125             


Asn Thr Leu Ile Cys Leu Val Asp Asn Ile Phe Pro Pro Val Val Asn 
    130                 135                 140                 


Ile Thr Trp Leu Ser Asn Gly Gln Ser Val Thr Glu Gly Val Ser Glu 
145                 150                 155                 160 


Thr Ser Phe Leu Ser Lys Ser Asp His Ser Phe Phe Lys Ile Ser Tyr 
                165                 170                 175     


Leu Thr Phe Leu Pro Ser Ala Asp Glu Ile Tyr Asp Cys Lys Val Glu 
            180                 185                 190         


His Trp Gly Leu Asp Gln Pro Leu Leu Lys His Trp Glu Pro Glu Ile 
        195                 200                 205             


Pro Ala Pro Met Ser Glu Leu Thr Glu Thr Val Val Cys Thr Leu Gly 
    210                 215                 220                 


Leu Ser Val Gly Leu Val Gly Ile Val Val Gly Thr Val Phe Ile Ile 
225                 230                 235                 240 


Gln Gly Leu Arg Ser Val Gly Ala Ser Arg His Gln Gly Pro Leu 
                245                 250                 255 


<210>  84
<211>  254
<212>  PRT
<213>  Homo sapiens

<400>  84

Met Ile Leu Asn Lys Ala Leu Met Leu Gly Ala Leu Ala Leu Thr Thr 
1               5                   10                  15      


Val Met Ser Pro Cys Gly Gly Glu Asp Ile Val Ala Asp His Val Ala 
            20                  25                  30          


Ser Tyr Gly Val Asn Leu Tyr Gln Ser Tyr Gly Pro Ser Gly Gln Phe 
        35                  40                  45              


Thr His Glu Phe Asp Gly Asp Glu Glu Phe Tyr Val Asp Leu Glu Arg 
    50                  55                  60                  


Lys Glu Thr Val Trp Lys Leu Pro Leu Phe His Arg Leu Arg Phe Asp 
65                  70                  75                  80  


Pro Gln Phe Ala Leu Thr Asn Ile Ala Val Leu Lys His Asn Leu Asn 
                85                  90                  95      


Ile Leu Ile Lys Arg Ser Asn Ser Thr Ala Ala Thr Asn Glu Val Pro 
            100                 105                 110         


Glu Val Thr Val Phe Ser Lys Ser Pro Val Thr Leu Gly Gln Pro Asn 
        115                 120                 125             


Thr Leu Ile Cys Leu Val Asp Asn Ile Phe Pro Pro Val Val Asn Ile 
    130                 135                 140                 


Thr Trp Leu Ser Asn Gly His Ser Val Thr Glu Gly Val Ser Glu Thr 
145                 150                 155                 160 


Ser Phe Leu Ser Lys Ser Asp His Ser Phe Phe Lys Ile Ser Tyr Leu 
                165                 170                 175     


Thr Phe Leu Pro Ser Ala Asp Glu Ile Tyr Asp Cys Lys Val Glu His 
            180                 185                 190         


Trp Gly Leu Asp Glu Pro Leu Leu Lys His Trp Glu Pro Glu Ile Pro 
        195                 200                 205             


Ala Pro Met Ser Glu Leu Thr Glu Thr Val Val Cys Ala Leu Gly Leu 
    210                 215                 220                 


Ser Val Gly Leu Val Gly Ile Val Val Gly Thr Val Leu Ile Ile Arg 
225                 230                 235                 240 


Gly Leu Arg Ser Val Gly Ala Ser Arg His Gln Gly Pro Leu 
                245                 250                 


<210>  85
<211>  254
<212>  PRT
<213>  Homo sapiens

<400>  85

Met Ile Leu Asn Lys Ala Leu Met Leu Gly Ala Leu Ala Leu Thr Thr 
1               5                   10                  15      


Val Met Ser Pro Cys Gly Gly Glu Asp Ile Val Ala Asp His Val Ala 
            20                  25                  30          


Ser Tyr Gly Val Asn Leu Tyr Gln Ser Tyr Gly Pro Ser Gly Gln Tyr 
        35                  40                  45              


Ser His Glu Phe Asp Gly Asp Glu Glu Phe Tyr Val Asp Leu Glu Arg 
    50                  55                  60                  


Lys Glu Thr Val Trp Gln Leu Pro Leu Phe Arg Arg Phe Arg Arg Phe 
65                  70                  75                  80  


Asp Pro Gln Phe Ala Leu Thr Asn Ile Ala Val Leu Lys His Asn Leu 
                85                  90                  95      


Asn Ile Val Ile Lys Arg Ser Asn Ser Thr Ala Ala Thr Asn Glu Val 
            100                 105                 110         


Pro Glu Val Thr Val Phe Ser Lys Ser Pro Val Thr Leu Gly Gln Pro 
        115                 120                 125             


Asn Thr Leu Ile Cys Leu Val Asp Asn Ile Phe Pro Pro Val Val Asn 
    130                 135                 140                 


Ile Thr Trp Leu Ser Asn Gly His Ser Val Thr Glu Gly Val Ser Thr 
145                 150                 155                 160 


Ser Phe Leu Ser Lys Ser Asp His Ser Phe Phe Lys Ile Ser Tyr Leu 
                165                 170                 175     


Thr Phe Leu Pro Ser Ala Asp Glu Ile Tyr Asp Cys Lys Val Glu His 
            180                 185                 190         


Trp Gly Leu Asp Glu Pro Leu Leu Lys His Trp Glu Pro Glu Ile Pro 
        195                 200                 205             


Thr Pro Met Ser Glu Leu Thr Glu Thr Val Val Cys Ala Leu Gly Leu 
    210                 215                 220                 


Ser Val Gly Leu Val Gly Ile Val Val Gly Thr Val Leu Ile Ile Arg 
225                 230                 235                 240 


Gly Leu Arg Ser Val Gly Ala Ser Arg His Gln Gly Pro Leu 
                245                 250                 


<210>  86
<211>  255
<212>  PRT
<213>  Homo sapiens

<400>  86

Met Ile Leu Asn Lys Ala Leu Met Leu Gly Ala Leu Ala Leu Thr Thr 
1               5                   10                  15      


Val Thr Ser Pro Cys Gly Gly Glu Asp Ile Val Ala Asp His Val Ala 
            20                  25                  30          


Ser Tyr Gly Val Asn Leu Tyr Gln Ser Tyr Gly Pro Ser Gly Gln Tyr 
        35                  40                  45              


Ser His Glu Phe Asp Gly Asp Glu Glu Phe Tyr Val Asp Leu Glu Arg 
    50                  55                  60                  


Lys Glu Thr Val Trp Gln Leu Pro Leu Phe Arg Arg Phe Arg Arg Phe 
65                  70                  75                  80  


Asp Pro Gln Phe Ala Leu Thr Asn Ile Ala Val Leu Lys His Asn Leu 
                85                  90                  95      


Asn Ile Val Ile Lys Arg Ser Asn Ser Thr Ala Ala Thr Asn Glu Val 
            100                 105                 110         


Pro Glu Val Thr Val Phe Ser Lys Ser Pro Val Thr Leu Gly Gln Pro 
        115                 120                 125             


Asn Thr Leu Ile Cys Leu Val Asp Asn Ile Phe Pro Pro Val Val Asn 
    130                 135                 140                 


Ile Thr Trp Leu Ser Asn Gly His Ser Val Thr Glu Gly Val Ser Glu 
145                 150                 155                 160 


Thr Ser Phe Leu Ser Lys Ser Asp His Ser Phe Phe Lys Ile Ser Tyr 
                165                 170                 175     


Leu Thr Phe Leu Pro Ser Asp Asp Glu Ile Tyr Asp Cys Lys Val Glu 
            180                 185                 190         


His Trp Gly Leu Asp Glu Pro Leu Leu Lys His Trp Glu Pro Glu Ile 
        195                 200                 205             


Pro Thr Pro Met Ser Glu Leu Thr Glu Thr Val Val Cys Ala Leu Gly 
    210                 215                 220                 


Leu Ser Val Gly Leu Val Gly Ile Val Val Gly Thr Val Leu Ile Ile 
225                 230                 235                 240 


Arg Gly Leu Arg Ser Val Gly Ala Ser Arg His Gln Gly Pro Leu 
                245                 250                 255 


<210>  87
<211>  254
<212>  PRT
<213>  Homo sapiens

<400>  87

Met Ile Leu Asn Lys Ala Leu Leu Leu Gly Ala Leu Ala Leu Thr Thr 
1               5                   10                  15      


Val Met Ser Pro Cys Gly Gly Glu Asp Ile Val Ala Asp His Val Ala 
            20                  25                  30          


Ser Tyr Gly Val Asn Leu Tyr Gln Ser Tyr Gly Pro Ser Gly Gln Tyr 
        35                  40                  45              


Thr His Glu Phe Asp Gly Asp Glu Gln Phe Tyr Val Asp Leu Gly Arg 
    50                  55                  60                  


Lys Glu Thr Val Trp Cys Leu Pro Val Leu Arg Gln Phe Arg Phe Asp 
65                  70                  75                  80  


Pro Gln Phe Ala Leu Thr Asn Ile Ala Val Thr Lys His Asn Leu Asn 
                85                  90                  95      


Ile Leu Ile Lys Arg Ser Asn Ser Thr Ala Ala Thr Asn Glu Val Pro 
            100                 105                 110         


Glu Val Thr Val Phe Ser Lys Ser Pro Val Thr Leu Gly Gln Pro Asn 
        115                 120                 125             


Thr Leu Ile Cys Leu Val Asp Asn Ile Phe Pro Pro Val Val Asn Ile 
    130                 135                 140                 


Thr Trp Leu Ser Asn Gly His Ser Val Thr Glu Gly Val Ser Glu Thr 
145                 150                 155                 160 


Ser Phe Leu Ser Lys Ser Asp His Ser Phe Phe Lys Ile Ser Tyr Leu 
                165                 170                 175     


Thr Phe Leu Pro Ser Ala Asp Glu Ile Tyr Asp Cys Lys Val Glu His 
            180                 185                 190         


Trp Gly Leu Asp Glu Pro Leu Leu Lys His Trp Glu Pro Glu Ile Pro 
        195                 200                 205             


Ala Pro Met Ser Glu Leu Thr Glu Thr Val Val Cys Ala Leu Gly Leu 
    210                 215                 220                 


Ser Val Gly Leu Val Gly Ile Val Val Gly Thr Val Phe Ile Ile Arg 
225                 230                 235                 240 


Gly Leu Arg Ser Val Gly Ala Ser Arg His Gln Gly Pro Leu 
                245                 250                 


<210>  88
<211>  254
<212>  PRT
<213>  Homo sapiens

<400>  88

Met Ile Leu Asn Lys Ala Leu Met Leu Gly Ala Leu Ala Leu Thr Thr 
1               5                   10                  15      


Val Met Ser Pro Cys Gly Gly Glu Asp Ile Val Ala Asp His Val Ala 
            20                  25                  30          


Ser Tyr Gly Val Asn Leu Tyr Gln Ser Tyr Gly Pro Ser Gly Gln Tyr 
        35                  40                  45              


Thr His Glu Phe Asp Gly Asp Glu Gln Phe Tyr Val Asp Leu Gly Arg 
    50                  55                  60                  


Lys Glu Thr Val Trp Cys Leu Pro Val Leu Arg Gln Phe Arg Phe Asp 
65                  70                  75                  80  


Pro Gln Phe Ala Leu Thr Asn Ile Ala Val Leu Lys His Asn Leu Asn 
                85                  90                  95      


Ser Leu Ile Lys Arg Ser Asn Ser Thr Ala Ala Thr Asn Glu Val Pro 
            100                 105                 110         


Glu Val Thr Val Phe Ser Lys Ser Pro Val Thr Leu Gly Gln Pro Asn 
        115                 120                 125             


Ile Leu Ile Cys Leu Val Asp Asn Ile Phe Pro Pro Val Val Asn Ile 
    130                 135                 140                 


Thr Trp Leu Ser Asn Gly His Ser Val Thr Glu Gly Val Ser Glu Thr 
145                 150                 155                 160 


Ser Phe Leu Ser Lys Ser Asp His Ser Phe Phe Lys Ile Ser Tyr Leu 
                165                 170                 175     


Thr Leu Leu Pro Ser Ala Glu Glu Ser Tyr Asp Cys Lys Val Glu His 
            180                 185                 190         


Trp Gly Leu Asp Lys Pro Leu Leu Lys His Trp Glu Pro Glu Ile Pro 
        195                 200                 205             


Ala Pro Met Ser Glu Leu Thr Glu Thr Val Val Cys Ala Leu Gly Leu 
    210                 215                 220                 


Ser Val Gly Leu Val Gly Ile Val Val Gly Thr Val Phe Ile Ile Arg 
225                 230                 235                 240 


Gly Leu Arg Ser Val Gly Ala Ser Arg His Gln Gly Pro Leu 
                245                 250                 


<210>  89
<211>  254
<212>  PRT
<213>  Homo sapiens

<400>  89

Met Ile Leu Asn Lys Ala Leu Met Leu Gly Thr Leu Ala Leu Thr Thr 
1               5                   10                  15      


Val Met Ser Pro Cys Gly Gly Glu Asp Ile Val Ala Asp His Val Ala 
            20                  25                  30          


Ser Tyr Gly Val Asn Leu Tyr Gln Ser Tyr Gly Pro Ser Gly Gln Tyr 
        35                  40                  45              


Thr His Glu Phe Asp Gly Asp Glu Gln Phe Tyr Val Asp Leu Gly Arg 
    50                  55                  60                  


Lys Glu Thr Val Trp Cys Leu Pro Val Leu Arg Gln Phe Arg Phe Asp 
65                  70                  75                  80  


Pro Gln Phe Ala Leu Thr Asn Ile Ala Val Leu Lys His Asn Leu Asn 
                85                  90                  95      


Ser Leu Ile Lys Arg Ser Asn Ser Thr Ala Ala Thr Asn Glu Val Pro 
            100                 105                 110         


Glu Val Thr Val Phe Ser Lys Ser Pro Val Thr Leu Gly Gln Pro Asn 
        115                 120                 125             


Ile Leu Ile Cys Leu Val Asp Asn Ile Phe Pro Pro Val Val Asn Ile 
    130                 135                 140                 


Thr Trp Leu Ser Asn Gly His Ser Val Thr Glu Gly Val Ser Glu Thr 
145                 150                 155                 160 


Ser Phe Leu Ser Lys Ser Asp His Ser Phe Phe Lys Ile Ser Tyr Leu 
                165                 170                 175     


Thr Leu Leu Pro Ser Ala Glu Glu Ser Tyr Asp Cys Lys Val Glu His 
            180                 185                 190         


Trp Gly Leu Asp Lys Pro Leu Leu Lys His Trp Glu Pro Glu Ile Pro 
        195                 200                 205             


Ala Pro Met Ser Glu Leu Thr Glu Thr Val Val Cys Ala Leu Gly Leu 
    210                 215                 220                 


Ser Val Gly Leu Val Gly Ile Val Val Gly Thr Val Phe Ile Ile Arg 
225                 230                 235                 240 


Gly Leu Arg Ser Val Gly Ala Ser Arg His Gln Gly Pro Leu 
                245                 250                 


<210>  90
<211>  254
<212>  PRT
<213>  Homo sapiens

<400>  90

Met Ile Leu Asn Lys Ala Leu Leu Leu Gly Ala Leu Ala Leu Thr Thr 
1               5                   10                  15      


Val Met Ser Pro Cys Gly Gly Glu Asp Ile Val Ala Asp His Val Ala 
            20                  25                  30          


Ser Tyr Gly Val Asn Leu Tyr Gln Ser Tyr Gly Pro Ser Gly Gln Phe 
        35                  40                  45              


Thr His Glu Phe Asp Gly Asp Glu Gln Phe Tyr Val Asp Leu Gly Arg 
    50                  55                  60                  


Lys Glu Thr Val Trp Cys Leu Pro Val Leu Arg Gln Phe Arg Phe Asp 
65                  70                  75                  80  


Pro Gln Phe Ala Leu Thr Asn Ile Ala Val Thr Lys His Asn Leu Asn 
                85                  90                  95      


Ile Leu Ile Lys Arg Ser Asn Ser Thr Ala Ala Thr Asn Glu Val Pro 
            100                 105                 110         


Glu Val Thr Val Phe Ser Lys Ser Pro Val Thr Leu Gly Gln Pro Asn 
        115                 120                 125             


Thr Leu Ile Cys Leu Val Asp Asn Ile Phe Pro Pro Val Val Asn Ile 
    130                 135                 140                 


Thr Trp Leu Ser Asn Gly His Ser Val Thr Glu Gly Val Ser Glu Thr 
145                 150                 155                 160 


Ser Phe Leu Ser Lys Ser Asp His Ser Phe Phe Lys Ile Ser Tyr Leu 
                165                 170                 175     


Thr Phe Leu Pro Ser Ala Asp Glu Ile Tyr Asp Cys Lys Val Glu His 
            180                 185                 190         


Trp Gly Leu Asp Glu Pro Leu Leu Lys His Trp Glu Pro Glu Ile Pro 
        195                 200                 205             


Ala Pro Met Ser Glu Leu Thr Glu Thr Val Val Cys Ala Leu Gly Leu 
    210                 215                 220                 


Ser Val Gly Leu Val Gly Ile Val Val Gly Thr Val Phe Ile Ile Arg 
225                 230                 235                 240 


Gly Leu Arg Ser Val Gly Ala Ser Arg His Gln Gly Pro Leu 
                245                 250                 


<210>  91
<211>  255
<212>  PRT
<213>  Homo sapiens

<400>  91

Met Ile Leu Asn Lys Ala Leu Leu Leu Gly Ala Leu Ala Leu Thr Ala 
1               5                   10                  15      


Val Met Ser Pro Cys Gly Gly Glu Asp Ile Val Ala Asp His Val Ala 
            20                  25                  30          


Ser Tyr Gly Val Asn Phe Tyr Gln Ser His Gly Pro Ser Gly Gln Tyr 
        35                  40                  45              


Thr His Glu Phe Asp Gly Asp Glu Glu Phe Tyr Val Asp Leu Glu Thr 
    50                  55                  60                  


Lys Glu Thr Val Trp Gln Leu Pro Met Phe Ser Lys Phe Ile Ser Phe 
65                  70                  75                  80  


Asp Pro Gln Ser Ala Leu Arg Asn Met Ala Val Gly Lys His Thr Leu 
                85                  90                  95      


Glu Phe Met Met Arg Gln Ser Asn Ser Thr Ala Ala Thr Asn Glu Val 
            100                 105                 110         


Pro Glu Val Thr Val Phe Ser Lys Phe Pro Val Thr Leu Gly Gln Pro 
        115                 120                 125             


Asn Thr Leu Ile Cys Leu Val Asp Asn Ile Phe Pro Pro Val Val Asn 
    130                 135                 140                 


Ile Thr Trp Leu Ser Asn Gly His Ser Val Thr Glu Gly Val Ser Glu 
145                 150                 155                 160 


Thr Ser Phe Leu Ser Lys Ser Asp His Ser Phe Phe Lys Ile Ser Tyr 
                165                 170                 175     


Leu Thr Phe Leu Pro Ser Ala Asp Glu Ile Tyr Asp Cys Lys Val Glu 
            180                 185                 190         


His Trp Gly Leu Asp Glu Pro Leu Leu Lys His Trp Glu Pro Glu Ile 
        195                 200                 205             


Pro Ala Pro Met Ser Glu Leu Thr Glu Thr Leu Val Cys Ala Leu Gly 
    210                 215                 220                 


Leu Ser Val Gly Leu Met Gly Ile Val Val Gly Thr Val Phe Ile Ile 
225                 230                 235                 240 


Gln Gly Leu Arg Ser Val Gly Ala Ser Arg His Gln Gly Leu Leu 
                245                 250                 255 


<210>  92
<211>  261
<212>  PRT
<213>  Homo sapiens

<400>  92

Met Ser Trp Lys Lys Ala Leu Arg Ile Pro Gly Gly Leu Arg Ala Ala 
1               5                   10                  15      


Thr Val Thr Leu Met Leu Ser Met Leu Ser Thr Pro Val Ala Glu Gly 
            20                  25                  30          


Arg Asp Ser Pro Glu Asp Phe Val Tyr Gln Phe Lys Gly Met Cys Tyr 
        35                  40                  45              


Phe Thr Asn Gly Thr Glu Arg Val Arg Leu Val Ser Arg Ser Ile Tyr 
    50                  55                  60                  


Asn Arg Glu Glu Ile Val Arg Phe Asp Ser Asp Val Gly Glu Phe Arg 
65                  70                  75                  80  


Ala Val Thr Leu Leu Gly Leu Pro Ala Ala Glu Tyr Trp Asn Ser Gln 
                85                  90                  95      


Lys Asp Ile Leu Glu Arg Lys Arg Ala Ala Val Asp Arg Val Cys Arg 
            100                 105                 110         


His Asn Tyr Gln Leu Glu Leu Arg Thr Thr Leu Gln Arg Arg Val Glu 
        115                 120                 125             


Pro Thr Val Thr Ile Ser Pro Ser Arg Thr Glu Ala Leu Asn His His 
    130                 135                 140                 


Asn Leu Leu Val Cys Ser Val Thr Asp Phe Tyr Pro Ala Gln Ile Lys 
145                 150                 155                 160 


Val Arg Trp Phe Arg Asn Asp Gln Glu Glu Thr Ala Gly Val Val Ser 
                165                 170                 175     


Thr Pro Leu Ile Arg Asn Gly Asp Trp Thr Phe Gln Ile Leu Val Met 
            180                 185                 190         


Leu Glu Met Thr Pro Gln Arg Gly Asp Val Tyr Thr Cys His Val Glu 
        195                 200                 205             


His Pro Ser Leu Gln Ser Pro Ile Thr Val Glu Trp Arg Ala Gln Ser 
    210                 215                 220                 


Glu Ser Ala Gln Ser Lys Met Leu Ser Gly Ile Gly Gly Phe Val Leu 
225                 230                 235                 240 


Gly Leu Ile Phe Leu Gly Leu Gly Leu Ile Ile His His Arg Ser Gln 
                245                 250                 255     


Lys Gly Leu Leu His 
            260     


<210>  93
<211>  261
<212>  PRT
<213>  Homo sapiens

<400>  93

Met Ser Trp Lys Lys Ala Leu Arg Ile Pro Gly Gly Leu Arg Ala Ala 
1               5                   10                  15      


Thr Val Thr Leu Met Leu Ser Met Leu Ser Thr Pro Val Ala Glu Gly 
            20                  25                  30          


Arg Asp Ser Pro Glu Asp Phe Val Tyr Gln Phe Lys Gly Met Cys Tyr 
        35                  40                  45              


Phe Thr Asn Gly Thr Glu Arg Val Arg Leu Val Ser Arg Ser Ile Tyr 
    50                  55                  60                  


Asn Arg Glu Glu Ile Val Arg Phe Asp Ser Asp Val Gly Glu Phe Arg 
65                  70                  75                  80  


Ala Val Thr Leu Leu Gly Leu Pro Ala Ala Glu Tyr Trp Asn Ser Gln 
                85                  90                  95      


Lys Asp Ile Leu Glu Arg Lys Arg Ala Ala Val Asp Arg Val Cys Arg 
            100                 105                 110         


His Asn Tyr Gln Leu Glu Leu Arg Thr Thr Leu Gln Arg Arg Val Glu 
        115                 120                 125             


Pro Thr Val Thr Ile Ser Pro Ser Arg Thr Glu Ala Leu Asn His His 
    130                 135                 140                 


Asn Leu Leu Val Cys Ser Val Thr Asp Phe Tyr Pro Ala Gln Ile Lys 
145                 150                 155                 160 


Val Arg Trp Phe Arg Asn Gly Gln Glu Glu Thr Ala Gly Val Val Ser 
                165                 170                 175     


Thr Pro Leu Ile Arg Asn Gly Asp Trp Thr Phe Gln Ile Leu Val Met 
            180                 185                 190         


Leu Glu Met Thr Pro Gln Arg Gly Asp Val Tyr Thr Cys His Val Glu 
        195                 200                 205             


His Pro Ser Leu Gln Ser Pro Ile Thr Val Glu Trp Arg Ala Gln Ser 
    210                 215                 220                 


Glu Ser Ala Gln Ser Lys Met Leu Ser Gly Ile Gly Gly Phe Val Leu 
225                 230                 235                 240 


Gly Leu Ile Phe Leu Gly Leu Gly Leu Ile Ile His His Arg Ser Gln 
                245                 250                 255     


Lys Gly Leu Leu His 
            260     


<210>  94
<211>  261
<212>  PRT
<213>  Homo sapiens

<400>  94

Met Ser Trp Lys Lys Ala Leu Arg Ile Pro Gly Gly Leu Arg Ala Ala 
1               5                   10                  15      


Thr Val Thr Leu Met Leu Ala Met Leu Ser Thr Pro Val Ala Glu Gly 
            20                  25                  30          


Arg Asp Ser Pro Glu Asp Phe Val Tyr Gln Phe Lys Ala Met Cys Tyr 
        35                  40                  45              


Phe Thr Asn Gly Thr Glu Arg Val Arg Tyr Val Thr Arg Tyr Ile Tyr 
    50                  55                  60                  


Asn Arg Glu Glu Tyr Ala Arg Phe Asp Ser Asp Val Glu Val Tyr Arg 
65                  70                  75                  80  


Ala Val Thr Pro Leu Gly Pro Pro Asp Ala Glu Tyr Trp Asn Ser Gln 
                85                  90                  95      


Lys Glu Val Leu Glu Arg Thr Arg Ala Glu Leu Asp Thr Val Cys Arg 
            100                 105                 110         


His Asn Tyr Gln Leu Glu Leu Arg Thr Thr Leu Gln Arg Arg Val Glu 
        115                 120                 125             


Pro Thr Val Thr Ile Ser Pro Ser Arg Thr Glu Ala Leu Asn His His 
    130                 135                 140                 


Asn Leu Leu Val Cys Ser Val Thr Asp Phe Tyr Pro Ala Gln Ile Lys 
145                 150                 155                 160 


Val Arg Trp Phe Arg Asn Asp Gln Glu Glu Thr Thr Gly Val Val Ser 
                165                 170                 175     


Thr Pro Leu Ile Arg Asn Gly Asp Trp Thr Phe Gln Ile Leu Val Met 
            180                 185                 190         


Leu Glu Met Thr Pro Gln His Gly Asp Val Tyr Thr Cys His Val Glu 
        195                 200                 205             


His Pro Ser Leu Gln Asn Pro Ile Thr Val Glu Trp Arg Ala Gln Ser 
    210                 215                 220                 


Glu Ser Ala Gln Ser Lys Met Leu Ser Gly Ile Gly Gly Phe Val Leu 
225                 230                 235                 240 


Gly Leu Ile Phe Leu Gly Leu Gly Leu Ile Ile His His Arg Ser Gln 
                245                 250                 255     


Lys Gly Leu Leu His 
            260     


<210>  95
<211>  261
<212>  PRT
<213>  Homo sapiens

<400>  95

Met Ser Trp Lys Lys Ala Leu Arg Ile Pro Gly Gly Leu Arg Val Ala 
1               5                   10                  15      


Thr Val Thr Leu Met Leu Ala Met Leu Ser Thr Pro Val Ala Glu Gly 
            20                  25                  30          


Arg Asp Ser Pro Glu Asp Phe Val Tyr Gln Phe Lys Gly Met Cys Tyr 
        35                  40                  45              


Phe Thr Asn Gly Thr Glu Arg Val Arg Leu Val Thr Arg Tyr Ile Tyr 
    50                  55                  60                  


Asn Arg Glu Glu Tyr Ala Arg Phe Asp Ser Asp Val Gly Val Tyr Arg 
65                  70                  75                  80  


Ala Val Thr Pro Leu Gly Pro Pro Ala Ala Glu Tyr Trp Asn Ser Gln 
                85                  90                  95      


Lys Glu Val Leu Glu Arg Thr Arg Ala Glu Leu Asp Thr Val Cys Arg 
            100                 105                 110         


His Asn Tyr Gln Leu Glu Leu Arg Thr Thr Leu Gln Arg Arg Val Glu 
        115                 120                 125             


Pro Thr Val Thr Ile Ser Pro Ser Arg Thr Glu Ala Leu Asn His His 
    130                 135                 140                 


Asn Leu Leu Val Cys Ser Val Thr Asp Phe Tyr Pro Ala Gln Ile Lys 
145                 150                 155                 160 


Val Arg Trp Phe Arg Asn Asp Gln Glu Glu Thr Thr Gly Val Val Ser 
                165                 170                 175     


Thr Pro Leu Ile Arg Asn Gly Asp Trp Thr Phe Gln Ile Leu Val Met 
            180                 185                 190         


Leu Glu Met Thr Pro Gln Arg Gly Asp Val Tyr Thr Cys His Val Glu 
        195                 200                 205             


His Pro Ser Leu Gln Asn Pro Ile Ile Val Glu Trp Arg Ala Gln Ser 
    210                 215                 220                 


Glu Ser Ala Gln Ser Lys Met Leu Ser Gly Ile Gly Gly Phe Val Leu 
225                 230                 235                 240 


Gly Leu Ile Phe Leu Gly Leu Gly Leu Ile Ile His His Arg Ser Gln 
                245                 250                 255     


Lys Gly Leu Leu His 
            260     


<210>  96
<211>  261
<212>  PRT
<213>  Homo sapiens

<400>  96

Met Ser Trp Lys Lys Ala Leu Arg Ile Pro Gly Gly Leu Arg Val Ala 
1               5                   10                  15      


Thr Val Thr Leu Met Leu Ala Met Leu Ser Thr Pro Val Ala Glu Gly 
            20                  25                  30          


Arg Asp Ser Pro Glu Asp Phe Val Tyr Gln Phe Lys Gly Met Cys Tyr 
        35                  40                  45              


Phe Thr Asn Gly Thr Glu Arg Val Arg Leu Val Thr Arg Tyr Ile Tyr 
    50                  55                  60                  


Asn Arg Glu Glu Tyr Ala Arg Phe Asp Ser Asp Val Gly Val Tyr Arg 
65                  70                  75                  80  


Ala Val Thr Pro Leu Gly Pro Pro Asp Ala Glu Tyr Trp Asn Ser Gln 
                85                  90                  95      


Lys Glu Val Leu Glu Arg Thr Arg Ala Glu Leu Asp Thr Val Cys Arg 
            100                 105                 110         


His Asn Tyr Gln Leu Glu Leu Arg Thr Thr Leu Gln Arg Arg Val Glu 
        115                 120                 125             


Pro Thr Val Thr Ile Ser Pro Ser Arg Thr Glu Ala Leu Asn His His 
    130                 135                 140                 


Asn Leu Leu Val Cys Ser Val Thr Asp Phe Tyr Pro Ala Gln Ile Lys 
145                 150                 155                 160 


Val Arg Trp Phe Arg Asn Asp Gln Glu Glu Thr Thr Gly Val Val Ser 
                165                 170                 175     


Thr Pro Leu Ile Arg Asn Gly Asp Trp Thr Phe Gln Ile Leu Val Met 
            180                 185                 190         


Leu Glu Met Thr Pro Gln Arg Gly Asp Val Tyr Thr Cys His Val Glu 
        195                 200                 205             


His Pro Ser Leu Gln Asn Pro Ile Ile Val Glu Trp Arg Ala Gln Ser 
    210                 215                 220                 


Glu Ser Ala Gln Ser Lys Met Leu Ser Gly Ile Gly Gly Phe Val Leu 
225                 230                 235                 240 


Gly Leu Ile Phe Leu Gly Leu Gly Leu Ile Ile His His Arg Ser Gln 
                245                 250                 255     


Lys Gly Leu Leu His 
            260     


<210>  97
<211>  261
<212>  PRT
<213>  Homo sapiens

<400>  97

Met Ser Trp Lys Lys Ala Leu Arg Ile Pro Gly Gly Leu Arg Ala Ala 
1               5                   10                  15      


Thr Val Thr Leu Met Leu Ala Met Leu Ser Thr Pro Val Ala Glu Gly 
            20                  25                  30          


Arg Asp Ser Pro Glu Asp Phe Val Tyr Gln Phe Lys Ala Met Cys Tyr 
        35                  40                  45              


Phe Thr Asn Gly Thr Glu Arg Val Arg Tyr Val Thr Arg Tyr Ile Tyr 
    50                  55                  60                  


Asn Arg Glu Glu Tyr Ala Arg Phe Asp Ser Asp Val Glu Val Tyr Arg 
65                  70                  75                  80  


Ala Val Thr Pro Leu Gly Pro Pro Ala Ala Glu Tyr Trp Asn Ser Gln 
                85                  90                  95      


Lys Glu Val Leu Glu Arg Thr Arg Ala Glu Leu Asp Thr Val Cys Arg 
            100                 105                 110         


His Asn Tyr Gln Leu Glu Leu Arg Thr Thr Leu Gln Arg Arg Val Glu 
        115                 120                 125             


Pro Thr Val Thr Ile Ser Pro Ser Arg Thr Glu Ala Leu Asn His His 
    130                 135                 140                 


Asn Leu Leu Val Cys Ser Val Thr Asp Phe Tyr Pro Ala Gln Ile Lys 
145                 150                 155                 160 


Val Arg Trp Phe Arg Asn Asp Gln Glu Glu Thr Thr Gly Val Val Ser 
                165                 170                 175     


Thr Pro Leu Ile Arg Asn Gly Asp Trp Thr Phe Gln Ile Leu Val Met 
            180                 185                 190         


Leu Glu Met Thr Pro Gln His Gly Asp Val Tyr Thr Cys His Val Glu 
        195                 200                 205             


His Pro Ser Leu Gln Asn Pro Ile Thr Val Glu Trp Arg Ala Gln Ser 
    210                 215                 220                 


Glu Ser Ala Gln Ser Lys Met Leu Ser Gly Ile Gly Gly Phe Val Leu 
225                 230                 235                 240 


Gly Leu Ile Phe Leu Gly Leu Gly Leu Ile Ile His His Arg Ser Gln 
                245                 250                 255     


Lys Gly Leu Leu His 
            260     


<210>  98
<211>  261
<212>  PRT
<213>  Homo sapiens

<400>  98

Met Ser Trp Lys Lys Ala Leu Arg Ile Pro Gly Gly Leu Arg Val Ala 
1               5                   10                  15      


Thr Val Thr Leu Met Leu Ala Met Leu Ser Thr Pro Val Ala Glu Gly 
            20                  25                  30          


Arg Asp Ser Pro Glu Asp Phe Val Phe Gln Phe Lys Gly Met Cys Tyr 
        35                  40                  45              


Phe Thr Asn Gly Thr Glu Leu Val Arg Gly Val Thr Arg Tyr Ile Tyr 
    50                  55                  60                  


Asn Arg Glu Glu Tyr Ala Arg Phe Asp Ser Asp Val Gly Val Tyr Arg 
65                  70                  75                  80  


Ala Val Thr Pro Leu Gly Arg Leu Asp Ala Glu Tyr Trp Asn Ser Gln 
                85                  90                  95      


Lys Asp Ile Leu Glu Glu Asp Arg Ala Ser Val Asp Thr Val Cys Arg 
            100                 105                 110         


His Asn Tyr Gln Leu Glu Leu Arg Thr Thr Leu Gln Arg Arg Val Glu 
        115                 120                 125             


Pro Thr Val Thr Ile Ser Pro Ser Arg Thr Glu Ala Leu Asn His His 
    130                 135                 140                 


Asn Leu Leu Val Cys Ser Val Thr Asp Phe Tyr Pro Ala Gln Ile Lys 
145                 150                 155                 160 


Val Arg Trp Phe Arg Asn Asp Gln Glu Glu Thr Thr Gly Val Val Ser 
                165                 170                 175     


Thr Pro Leu Ile Arg Asn Gly Asp Trp Thr Phe Gln Ile Leu Val Met 
            180                 185                 190         


Leu Glu Met Thr Pro Gln Arg Gly Asp Val Tyr Thr Cys His Val Glu 
        195                 200                 205             


His Pro Ser Leu Gln Asn Pro Ile Ile Val Glu Trp Arg Ala Gln Ser 
    210                 215                 220                 


Glu Ser Ala Gln Ser Lys Met Leu Ser Gly Ile Gly Gly Phe Val Leu 
225                 230                 235                 240 


Gly Leu Ile Phe Leu Gly Leu Gly Leu Ile Ile His His Arg Ser Gln 
                245                 250                 255     


Lys Gly Leu Leu His 
            260     


<210>  99
<211>  261
<212>  PRT
<213>  Homo sapiens

<400>  99

Met Ser Trp Lys Lys Ala Leu Arg Ile Pro Gly Gly Leu Arg Val Ala 
1               5                   10                  15      


Thr Val Thr Leu Met Leu Ala Met Leu Ser Thr Pro Val Ala Glu Gly 
            20                  25                  30          


Arg Asp Ser Pro Glu Asp Phe Val Phe Gln Phe Lys Gly Met Cys Tyr 
        35                  40                  45              


Phe Thr Asn Gly Thr Glu Arg Val Arg Gly Val Thr Arg Tyr Ile Tyr 
    50                  55                  60                  


Asn Arg Glu Glu Tyr Ala Arg Phe Asp Ser Asp Val Gly Val Tyr Arg 
65                  70                  75                  80  


Ala Val Thr Pro Leu Gly Arg Leu Asp Ala Glu Tyr Trp Asn Ser Gln 
                85                  90                  95      


Lys Asp Ile Leu Glu Glu Asp Arg Ala Ser Val Asp Thr Val Cys Arg 
            100                 105                 110         


His Asn Tyr Gln Leu Glu Leu Arg Thr Thr Leu Gln Arg Arg Val Glu 
        115                 120                 125             


Pro Thr Val Thr Ile Ser Pro Ser Arg Thr Glu Ala Leu Asn His His 
    130                 135                 140                 


Asn Leu Leu Val Cys Ser Val Thr Asp Phe Tyr Pro Ala Gln Ile Lys 
145                 150                 155                 160 


Val Arg Trp Phe Arg Asn Asp Gln Glu Glu Thr Thr Gly Val Val Ser 
                165                 170                 175     


Thr Pro Leu Ile Arg Asn Gly Asp Trp Thr Phe Gln Ile Leu Val Met 
            180                 185                 190         


Leu Glu Met Thr Pro Gln Arg Gly Asp Val Tyr Thr Cys His Val Glu 
        195                 200                 205             


His Pro Ser Leu Gln Asn Pro Ile Ile Val Glu Trp Arg Ala Gln Ser 
    210                 215                 220                 


Glu Ser Ala Gln Ser Lys Met Leu Ser Gly Ile Gly Gly Phe Val Leu 
225                 230                 235                 240 


Gly Leu Ile Phe Leu Gly Leu Gly Leu Ile Ile His His Arg Ser Gln 
                245                 250                 255     


Lys Gly Leu Leu His 
            260     


<210>  100
<211>  261
<212>  PRT
<213>  Homo sapiens

<400>  100

Met Ser Trp Lys Lys Ser Leu Arg Ile Pro Gly Asp Leu Arg Val Ala 
1               5                   10                  15      


Thr Val Thr Leu Met Leu Ala Ile Leu Ser Ser Ser Leu Ala Glu Gly 
            20                  25                  30          


Arg Asp Ser Pro Glu Asp Phe Val Tyr Gln Phe Lys Gly Leu Cys Tyr 
        35                  40                  45              


Phe Thr Asn Gly Thr Glu Arg Val Arg Gly Val Thr Arg His Ile Tyr 
    50                  55                  60                  


Asn Arg Glu Glu Tyr Val Arg Phe Asp Ser Asp Val Gly Val Tyr Arg 
65                  70                  75                  80  


Ala Val Thr Pro Gln Gly Arg Pro Val Ala Glu Tyr Trp Asn Ser Gln 
                85                  90                  95      


Lys Glu Val Leu Glu Gly Ala Arg Ala Ser Val Asp Arg Val Cys Arg 
            100                 105                 110         


His Asn Tyr Glu Val Ala Tyr Arg Gly Ile Leu Gln Arg Arg Val Glu 
        115                 120                 125             


Pro Thr Val Thr Ile Ser Pro Ser Arg Thr Glu Ala Leu Asn His His 
    130                 135                 140                 


Asn Leu Leu Ile Cys Ser Val Thr Asp Phe Tyr Pro Ser Gln Ile Lys 
145                 150                 155                 160 


Val Arg Trp Phe Arg Asn Asp Gln Glu Glu Thr Ala Gly Val Val Ser 
                165                 170                 175     


Thr Pro Leu Ile Arg Asn Gly Asp Trp Thr Phe Gln Ile Leu Val Met 
            180                 185                 190         


Leu Glu Met Thr Pro Gln Arg Gly Asp Val Tyr Thr Cys His Val Glu 
        195                 200                 205             


His Pro Ser Leu Gln Ser Pro Ile Thr Val Glu Trp Arg Ala Gln Ser 
    210                 215                 220                 


Glu Ser Ala Gln Ser Lys Met Leu Ser Gly Val Gly Gly Phe Val Leu 
225                 230                 235                 240 


Gly Leu Ile Phe Leu Gly Leu Gly Leu Ile Ile Arg Gln Arg Ser Arg 
                245                 250                 255     


Lys Gly Leu Leu His 
            260     


<210>  101
<211>  269
<212>  PRT
<213>  Homo sapiens

<400>  101

Met Ser Trp Lys Lys Ser Leu Arg Ile Pro Gly Asp Leu Arg Val Ala 
1               5                   10                  15      


Thr Val Thr Leu Met Leu Ala Ile Leu Ser Ser Ser Leu Ala Glu Gly 
            20                  25                  30          


Arg Asp Ser Pro Glu Asp Phe Val Tyr Gln Phe Lys Gly Leu Cys Tyr 
        35                  40                  45              


Phe Thr Asn Gly Thr Glu Arg Val Arg Gly Val Thr Arg His Ile Tyr 
    50                  55                  60                  


Asn Arg Glu Glu Tyr Val Arg Phe Asp Ser Asp Val Gly Val Tyr Arg 
65                  70                  75                  80  


Ala Val Thr Pro Gln Gly Arg Pro Asp Ala Glu Tyr Trp Asn Ser Gln 
                85                  90                  95      


Lys Glu Val Leu Glu Gly Ala Arg Ala Ser Val Asp Arg Val Cys Arg 
            100                 105                 110         


His Asn Tyr Glu Val Ala Tyr Arg Gly Ile Leu Gln Arg Arg Val Glu 
        115                 120                 125             


Pro Thr Val Thr Ile Ser Pro Ser Arg Thr Glu Ala Leu Asn His His 
    130                 135                 140                 


Asn Leu Leu Ile Cys Ser Val Thr Asp Phe Tyr Pro Ser Gln Ile Lys 
145                 150                 155                 160 


Val Arg Trp Phe Arg Asn Asp Gln Glu Glu Thr Ala Gly Val Val Ser 
                165                 170                 175     


Thr Pro Leu Ile Arg Asn Gly Asp Trp Thr Phe Gln Ile Leu Val Met 
            180                 185                 190         


Leu Glu Met Thr Pro Gln Arg Gly Asp Val Tyr Thr Cys His Val Glu 
        195                 200                 205             


His Pro Ser Leu Gln Ser Pro Ile Thr Val Glu Trp Arg Ala Gln Ser 
    210                 215                 220                 


Glu Ser Ala Gln Ser Lys Met Leu Ser Gly Val Gly Gly Phe Val Leu 
225                 230                 235                 240 


Gly Leu Ile Phe Leu Gly Leu Gly Leu Ile Ile Arg Gln Arg Ser Arg 
                245                 250                 255     


Lys Gly Pro Gln Gly Pro Pro Pro Ala Gly Leu Leu His 
            260                 265                 


<210>  102
<211>  269
<212>  PRT
<213>  Homo sapiens

<400>  102

Met Ser Trp Lys Lys Ala Leu Arg Ile Pro Gly Gly Leu Arg Ala Pro 
1               5                   10                  15      


Thr Val Thr Leu Met Leu Ala Met Leu Ser Thr Pro Val Ala Glu Gly 
            20                  25                  30          


Arg Asp Pro Pro Glu Asp Phe Val Leu Gln Phe Lys Ala Met Cys Tyr 
        35                  40                  45              


Phe Thr Asn Gly Thr Glu Arg Val Arg Tyr Val Thr Arg Tyr Ile Tyr 
    50                  55                  60                  


Asn Arg Glu Glu Asp Val Arg Phe Asp Ser Asp Val Gly Val Tyr Arg 
65                  70                  75                  80  


Ala Val Thr Pro Gln Gly Arg Pro Asp Ala Glu Tyr Trp Asn Ser Gln 
                85                  90                  95      


Lys Asp Ile Leu Glu Arg Thr Arg Ala Glu Leu Asp Thr Val Cys Arg 
            100                 105                 110         


His Asn Tyr Glu Val Ala Phe Arg Gly Ile Leu Gln Arg Arg Val Glu 
        115                 120                 125             


Pro Thr Val Thr Ile Ser Pro Ser Arg Thr Glu Ala Leu Asn His His 
    130                 135                 140                 


Asn Leu Leu Val Cys Ser Val Thr Asp Phe Tyr Pro Gly Gln Ile Lys 
145                 150                 155                 160 


Val Arg Trp Phe Arg Asn Asp Gln Glu Glu Thr Ala Gly Val Val Ser 
                165                 170                 175     


Thr Pro Leu Ile Arg Asn Gly Asp Trp Thr Phe Gln Ile Leu Val Met 
            180                 185                 190         


Leu Glu Met Thr Pro Gln His Gly Asp Val Tyr Thr Cys His Val Glu 
        195                 200                 205             


His Pro Ser Leu Gln Ser Pro Ile Thr Val Glu Trp Arg Ala Gln Ser 
    210                 215                 220                 


Glu Ser Ala Gln Asn Lys Met Leu Ser Gly Ile Gly Gly Phe Val Leu 
225                 230                 235                 240 


Gly Leu Ile Phe Leu Gly Leu Gly Leu Ile Ile Arg Gln Arg Ser Gln 
                245                 250                 255     


Lys Gly Pro Gln Gly Pro Pro Pro Ala Gly Leu Leu His 
            260                 265                 


<210>  103
<211>  269
<212>  PRT
<213>  Homo sapiens

<400>  103

Met Ser Trp Lys Lys Ala Leu Arg Ile Pro Gly Asp Leu Arg Val Ala 
1               5                   10                  15      


Thr Val Thr Leu Met Leu Ala Met Leu Ser Ser Leu Leu Ala Glu Gly 
            20                  25                  30          


Arg Asp Ser Pro Glu Asp Phe Val Phe Gln Phe Lys Gly Met Cys Tyr 
        35                  40                  45              


Phe Thr Asn Gly Thr Glu Arg Val Arg Leu Val Thr Arg Tyr Ile Tyr 
    50                  55                  60                  


Asn Arg Glu Glu Tyr Ala Arg Phe Asp Ser Asp Val Gly Val Tyr Arg 
65                  70                  75                  80  


Ala Val Thr Pro Gln Gly Arg Pro Asp Ala Glu Tyr Trp Asn Ser Gln 
                85                  90                  95      


Lys Glu Val Leu Glu Gly Thr Arg Ala Glu Leu Asp Thr Val Cys Arg 
            100                 105                 110         


His Asn Tyr Glu Val Ala Phe Arg Gly Ile Leu Gln Arg Arg Val Glu 
        115                 120                 125             


Pro Thr Val Thr Ile Ser Pro Ser Arg Thr Glu Ala Leu Asn His His 
    130                 135                 140                 


Asn Leu Leu Val Cys Ser Val Thr Asp Phe Tyr Pro Gly Gln Ile Lys 
145                 150                 155                 160 


Val Arg Trp Phe Arg Asn Asp Gln Glu Glu Thr Ala Gly Val Val Ser 
                165                 170                 175     


Thr Pro Leu Ile Arg Asn Gly Asp Trp Thr Phe Gln Ile Leu Val Met 
            180                 185                 190         


Leu Glu Met Thr Pro Gln Arg Gly Asp Val Tyr Thr Cys His Val Glu 
        195                 200                 205             


His Pro Ser Leu Gln Ser Pro Ile Thr Val Glu Trp Arg Ala Gln Ser 
    210                 215                 220                 


Glu Ser Ala Gln Ser Lys Met Leu Ser Gly Val Gly Gly Phe Val Leu 
225                 230                 235                 240 


Gly Leu Ile Phe Leu Gly Leu Gly Leu Ile Ile Arg Gln Arg Ser Gln 
                245                 250                 255     


Lys Gly Pro Gln Gly Pro Pro Pro Ala Gly Leu Leu His 
            260                 265                 


<210>  104
<211>  227
<212>  PRT
<213>  Homo sapiens

<400>  104

Met Ala Leu Gln Ile Pro Gly Gly Phe Trp Ala Ala Ala Val Thr Val 
1               5                   10                  15      


Met Leu Val Met Leu Ser Thr Pro Val Ala Glu Ala Arg Asp Phe Pro 
            20                  25                  30          


Lys Asp Phe Leu Val Gln Phe Lys Gly Met Cys Tyr Phe Thr Asn Gly 
        35                  40                  45              


Thr Glu Arg Val Arg Gly Val Ala Arg Tyr Ile Tyr Asn Arg Glu Glu 
    50                  55                  60                  


Tyr Gly Arg Phe Asp Ser Asp Val Gly Glu Phe Gln Ala Val Thr Glu 
65                  70                  75                  80  


Leu Gly Arg Ser Ile Glu Asp Trp Asn Asn Tyr Lys Asp Phe Leu Glu 
                85                  90                  95      


Gln Glu Arg Ala Ala Val Asp Lys Val Cys Arg His Asn Tyr Glu Ala 
            100                 105                 110         


Glu Leu Arg Thr Thr Leu Gln Arg Gln Val Glu Pro Thr Val Thr Ile 
        115                 120                 125             


Ser Pro Ser Arg Thr Glu Ala Leu Asn His His Asn Leu Leu Val Cys 
    130                 135                 140                 


Ser Val Thr Asp Phe Tyr Pro Ala Gln Ile Lys Val Arg Trp Phe Arg 
145                 150                 155                 160 


Asn Asp Gln Glu Glu Thr Ala Gly Val Val Ser Thr Ser Leu Ile Arg 
                165                 170                 175     


Asn Gly Asp Trp Thr Phe Gln Ile Leu Val Met Leu Glu Ile Thr Pro 
            180                 185                 190         


Gln Arg Gly Asp Ile Tyr Thr Cys Gln Val Glu His Pro Ser Leu Gln 
        195                 200                 205             


Ser Pro Ile Thr Val Glu Trp Arg Pro Arg Gly Pro Pro Pro Ala Gly 
    210                 215                 220                 


Leu Leu His 
225         


<210>  105
<211>  264
<212>  PRT
<213>  Homo sapiens

<400>  105

Met Ala Leu Gln Ile Pro Gly Gly Phe Trp Ala Ala Ala Val Thr Val 
1               5                   10                  15      


Met Leu Val Met Leu Ser Thr Pro Val Ala Glu Ala Arg Asp Phe Pro 
            20                  25                  30          


Lys Asp Phe Leu Val Gln Phe Lys Gly Met Cys Tyr Phe Thr Asn Gly 
        35                  40                  45              


Thr Glu Arg Val Arg Gly Val Ala Arg Tyr Ile Tyr Asn Arg Glu Glu 
    50                  55                  60                  


Tyr Gly Arg Phe Asp Ser Asp Val Gly Glu Phe Gln Ala Val Thr Glu 
65                  70                  75                  80  


Leu Gly Arg Ser Ile Glu Asp Trp Asn Asn Tyr Lys Asp Phe Leu Glu 
                85                  90                  95      


Gln Glu Arg Ala Ala Val Asp Lys Val Cys Arg His Asn Tyr Glu Ala 
            100                 105                 110         


Glu Leu Arg Thr Thr Leu Gln Arg Gln Val Glu Pro Thr Val Thr Ile 
        115                 120                 125             


Ser Pro Ser Arg Thr Glu Ala Leu Asn His His Asn Leu Leu Val Cys 
    130                 135                 140                 


Ser Val Thr Asp Phe Tyr Pro Ala Gln Ile Lys Val Arg Trp Phe Arg 
145                 150                 155                 160 


Asn Asp Gln Glu Glu Thr Ala Gly Val Val Ser Thr Ser Leu Ile Arg 
                165                 170                 175     


Asn Gly Asp Trp Thr Phe Gln Ile Leu Val Met Leu Glu Ile Thr Pro 
            180                 185                 190         


Gln Arg Gly Asp Ile Tyr Thr Cys Gln Val Glu His Pro Ser Leu Gln 
        195                 200                 205             


Ser Pro Ile Thr Val Glu Trp Arg Ala Gln Ser Glu Ser Ala Gln Ser 
    210                 215                 220                 


Lys Met Leu Ser Gly Ile Gly Gly Phe Val Leu Gly Leu Ile Phe Leu 
225                 230                 235                 240 


Gly Leu Gly Leu Ile Ile Arg His Arg Gly Gln Lys Gly Pro Arg Gly 
                245                 250                 255     


Pro Pro Pro Ala Gly Leu Leu His 
            260                 


<210>  106
<211>  159
<212>  PRT
<213>  Homo sapiens

<400>  106

Met Lys Asn His Leu Leu Phe Trp Gly Val Leu Ala Val Phe Ile Lys 
1               5                   10                  15      


Ala Val His Val Lys Ala Gln Glu Asp Glu Arg Ile Val Leu Val Asp 
            20                  25                  30          


Asn Lys Cys Lys Cys Ala Arg Ile Thr Ser Arg Ile Ile Arg Ser Ser 
        35                  40                  45              


Glu Asp Pro Asn Glu Asp Ile Val Glu Arg Asn Ile Arg Ile Ile Val 
    50                  55                  60                  


Pro Leu Asn Asn Arg Glu Asn Ile Ser Asp Pro Thr Ser Pro Leu Arg 
65                  70                  75                  80  


Thr Arg Phe Val Tyr His Leu Ser Asp Leu Cys Lys Lys Cys Asp Pro 
                85                  90                  95      


Thr Glu Val Glu Leu Asp Asn Gln Ile Val Thr Ala Thr Gln Ser Asn 
            100                 105                 110         


Ile Cys Asp Glu Asp Ser Ala Thr Glu Thr Cys Tyr Thr Tyr Asp Arg 
        115                 120                 125             


Asn Lys Cys Tyr Thr Ala Val Val Pro Leu Val Tyr Gly Gly Glu Thr 
    130                 135                 140                 


Lys Met Val Glu Thr Ala Leu Thr Pro Asp Ala Cys Tyr Pro Asp 
145                 150                 155                 


<210>  107
<211>  178
<212>  PRT
<213>  Homo sapiens

<400>  107

Ile Lys Glu Glu His Val Ile Ile Gln Ala Glu Phe Tyr Leu Asn Pro 
1               5                   10                  15      


Asp Gln Ser Gly Glu Phe Met Phe Asp Phe Asp Gly Asp Glu Ile Phe 
            20                  25                  30          


His Val Asp Met Ala Lys Lys Glu Thr Val Trp Arg Leu Glu Glu Phe 
        35                  40                  45              


Gly Arg Phe Ala Ser Phe Glu Ala Gln Gly Ala Leu Ala Asn Ile Ala 
    50                  55                  60                  


Val Asp Lys Ala Asn Leu Glu Ile Met Thr Lys Arg Ser Asn Tyr Thr 
65                  70                  75                  80  


Pro Ile Thr Asn Val Pro Pro Glu Val Thr Val Leu Thr Asn Ser Pro 
                85                  90                  95      


Val Glu Leu Arg Glu Pro Asn Val Leu Ile Cys Phe Ile Asp Lys Phe 
            100                 105                 110         


Thr Pro Pro Val Val Asn Val Thr Trp Leu Arg Asn Gly Lys Pro Val 
        115                 120                 125             


Thr Thr Gly Val Ser Glu Thr Val Phe Leu Pro Arg Glu Asp His Leu 
    130                 135                 140                 


Phe Arg Lys Phe His Tyr Leu Pro Phe Leu Pro Ser Thr Glu Asp Val 
145                 150                 155                 160 


Tyr Asp Cys Arg Val Glu His Trp Gly Leu Asp Glu Pro Leu Leu Lys 
                165                 170                 175     


His Trp 
        


<210>  108
<211>  79
<212>  PRT
<213>  Homo sapiens

<400>  108

Val Ile Ile Gln Ala Glu Phe Tyr Leu Asn Pro Asp Gln Ser Gly Glu 
1               5                   10                  15      


Phe Met Phe Asp Phe Asp Gly Asp Glu Ile Phe His Val Asp Met Ala 
            20                  25                  30          


Lys Lys Glu Thr Val Trp Arg Leu Glu Glu Phe Gly Arg Phe Ala Ser 
        35                  40                  45              


Phe Glu Ala Gln Gly Ala Leu Ala Asn Ile Ala Val Asp Lys Ala Asn 
    50                  55                  60                  


Leu Glu Ile Met Thr Lys Arg Ser Asn Tyr Thr Pro Ile Thr Asn 
65                  70                  75                  


<210>  109
<211>  94
<212>  PRT
<213>  Homo sapiens

<400>  109

Val Pro Pro Glu Val Thr Val Leu Thr Asn Ser Pro Val Glu Leu Arg 
1               5                   10                  15      


Glu Pro Asn Val Leu Ile Cys Phe Ile Asp Lys Phe Thr Pro Pro Val 
            20                  25                  30          


Val Asn Val Thr Trp Leu Arg Asn Gly Lys Pro Val Thr Thr Gly Val 
        35                  40                  45              


Ser Glu Thr Val Phe Leu Pro Arg Glu Asp His Leu Phe Arg Lys Phe 
    50                  55                  60                  


His Tyr Leu Pro Phe Leu Pro Ser Thr Glu Asp Val Tyr Asp Cys Arg 
65                  70                  75                  80  


Val Glu His Trp Gly Leu Asp Glu Pro Leu Leu Lys His Trp 
                85                  90                  


<210>  110
<211>  98
<212>  PRT
<213>  Homo sapiens

<400>  110

Val Pro Glu Ala Pro Thr Pro Met Trp Pro Asp Asp Leu Gln Asn His 
1               5                   10                  15      


Thr Phe Leu His Thr Val Tyr Cys Gln Asp Gly Ser Pro Ser Val Gly 
            20                  25                  30          


Leu Ser Glu Ala Tyr Asp Glu Asp Gln Leu Phe Phe Phe Asp Phe Ser 
        35                  40                  45              


Gln Asn Thr Arg Val Pro Arg Leu Pro Glu Phe Ala Asp Trp Ala Gln 
    50                  55                  60                  


Glu Gln Gly Asp Ala Pro Ala Ile Leu Phe Asp Lys Glu Phe Cys Glu 
65                  70                  75                  80  


Trp Met Ile Gln Gln Ile Gly Pro Lys Leu Asp Gly Lys Ile Pro Val 
                85                  90                  95      


Ser Arg 
        


<210>  111
<211>  93
<212>  PRT
<213>  Homo sapiens

<400>  111

Gly Phe Pro Ile Ala Glu Val Phe Thr Leu Lys Pro Leu Glu Phe Gly 
1               5                   10                  15      


Lys Pro Asn Thr Leu Val Cys Phe Val Ser Asn Leu Phe Pro Pro Met 
            20                  25                  30          


Leu Thr Val Asn Trp Gln His His Ser Val Pro Val Glu Gly Phe Gly 
        35                  40                  45              


Pro Thr Phe Val Ser Ala Val Asp Gly Leu Ser Phe Gln Ala Phe Ser 
    50                  55                  60                  


Tyr Leu Asn Phe Thr Pro Glu Pro Ser Asp Ile Phe Ser Cys Ile Val 
65                  70                  75                  80  


Thr His Glu Ile Asp Arg Tyr Thr Ala Ile Ala Tyr Trp 
                85                  90              


<210>  112
<211>  85
<212>  PRT
<213>  Homo sapiens

<400>  112

Thr Lys Ala Asp His Met Gly Ser Tyr Gly Pro Ala Phe Tyr Gln Ser 
1               5                   10                  15      


Tyr Gly Ala Ser Gly Gln Phe Thr His Glu Phe Asp Glu Glu Gln Leu 
            20                  25                  30          


Phe Ser Val Asp Leu Lys Lys Ser Glu Ala Val Trp Arg Leu Pro Glu 
        35                  40                  45              


Phe Gly Asp Phe Ala Arg Phe Asp Pro Gln Gly Gly Leu Ala Gly Ile 
    50                  55                  60                  


Ala Ala Ile Lys Ala His Leu Asp Ile Leu Val Glu Arg Ser Asn Arg 
65                  70                  75                  80  


Ser Arg Ala Ile Asn 
                85  


<210>  113
<211>  94
<212>  PRT
<213>  Homo sapiens

<400>  113

Val Pro Pro Arg Val Thr Val Leu Pro Lys Ser Arg Val Glu Leu Gly 
1               5                   10                  15      


Gln Pro Asn Ile Leu Ile Cys Ile Val Asp Asn Ile Phe Pro Pro Val 
            20                  25                  30          


Ile Asn Ile Thr Trp Leu Arg Asn Gly Gln Thr Val Thr Glu Gly Val 
        35                  40                  45              


Ala Gln Thr Ser Phe Tyr Ser Gln Pro Asp His Leu Phe Arg Lys Phe 
    50                  55                  60                  


His Tyr Leu Pro Phe Val Pro Ser Ala Glu Asp Val Tyr Asp Cys Gln 
65                  70                  75                  80  


Val Glu His Trp Gly Leu Asp Ala Pro Leu Leu Arg His Trp 
                85                  90                  


<210>  114
<211>  85
<212>  PRT
<213>  Homo sapiens

<400>  114

Ala Ile Lys Ala Asp His Val Ser Thr Tyr Ala Ala Phe Val Gln Thr 
1               5                   10                  15      


His Arg Pro Thr Gly Glu Phe Met Phe Glu Phe Asp Glu Asp Glu Met 
            20                  25                  30          


Phe Tyr Val Asp Leu Asp Lys Lys Glu Thr Val Trp His Leu Glu Glu 
        35                  40                  45              


Phe Gly Gln Ala Phe Ser Phe Glu Ala Gln Gly Gly Leu Ala Asn Ile 
    50                  55                  60                  


Ala Ile Leu Asn Asn Asn Leu Asn Thr Leu Ile Gln Arg Ser Asn His 
65                  70                  75                  80  


Thr Gln Ala Thr Asn 
                85  


<210>  115
<211>  94
<212>  PRT
<213>  Homo sapiens

<400>  115

Asp Pro Pro Glu Val Thr Val Phe Pro Lys Glu Pro Val Glu Leu Gly 
1               5                   10                  15      


Gln Pro Asn Thr Leu Ile Cys His Ile Asp Lys Phe Phe Pro Pro Val 
            20                  25                  30          


Leu Asn Val Thr Trp Leu Cys Asn Gly Glu Leu Val Thr Glu Gly Val 
        35                  40                  45              


Ala Glu Ser Leu Phe Leu Pro Arg Thr Asp Tyr Ser Phe His Lys Phe 
    50                  55                  60                  


His Tyr Leu Thr Phe Val Pro Ser Ala Glu Asp Phe Tyr Asp Cys Arg 
65                  70                  75                  80  


Val Glu His Trp Gly Leu Asp Gln Pro Leu Leu Lys His Trp 
                85                  90                  


<210>  116
<211>  181
<212>  PRT
<213>  Homo sapiens

<400>  116

Glu Asp Ile Val Ala Asp His Val Ala Ser Cys Gly Val Asn Leu Tyr 
1               5                   10                  15      


Gln Phe Tyr Gly Pro Ser Gly Gln Tyr Thr His Glu Phe Asp Gly Asp 
            20                  25                  30          


Glu Gln Phe Tyr Val Asp Leu Glu Arg Lys Glu Thr Ala Trp Arg Trp 
        35                  40                  45              


Pro Glu Phe Ser Lys Phe Gly Gly Phe Asp Pro Gln Gly Ala Leu Arg 
    50                  55                  60                  


Asn Met Ala Val Ala Lys His Asn Leu Asn Ile Met Ile Lys Arg Tyr 
65                  70                  75                  80  


Asn Ser Thr Ala Ala Thr Asn Glu Val Pro Glu Val Thr Val Phe Ser 
                85                  90                  95      


Lys Ser Pro Val Thr Leu Gly Gln Pro Asn Thr Leu Ile Cys Leu Val 
            100                 105                 110         


Asp Asn Ile Phe Pro Pro Val Val Asn Ile Thr Trp Leu Ser Asn Gly 
        115                 120                 125             


Gln Ser Val Thr Glu Gly Val Ser Glu Thr Ser Phe Leu Ser Lys Ser 
    130                 135                 140                 


Asp His Ser Phe Phe Lys Ile Ser Tyr Leu Thr Phe Leu Pro Ser Ala 
145                 150                 155                 160 


Asp Glu Ile Tyr Asp Cys Lys Val Glu His Trp Gly Leu Asp Gln Pro 
                165                 170                 175     


Leu Leu Lys His Trp 
            180     


<210>  117
<211>  87
<212>  PRT
<213>  Homo sapiens

<400>  117

Glu Asp Ile Val Ala Asp His Val Ala Ser Cys Gly Val Asn Leu Tyr 
1               5                   10                  15      


Gln Phe Tyr Gly Pro Ser Gly Gln Tyr Thr His Glu Phe Asp Gly Asp 
            20                  25                  30          


Glu Gln Phe Tyr Val Asp Leu Glu Arg Lys Glu Thr Ala Trp Arg Trp 
        35                  40                  45              


Pro Glu Phe Ser Lys Phe Gly Gly Phe Asp Pro Gln Gly Ala Leu Arg 
    50                  55                  60                  


Asn Met Ala Val Ala Lys His Asn Leu Asn Ile Met Ile Lys Arg Tyr 
65                  70                  75                  80  


Asn Ser Thr Ala Ala Thr Asn 
                85          


<210>  118
<211>  94
<212>  PRT
<213>  Homo sapiens

<400>  118

Glu Val Pro Glu Val Thr Val Phe Ser Lys Ser Pro Val Thr Leu Gly 
1               5                   10                  15      


Gln Pro Asn Thr Leu Ile Cys Leu Val Asp Asn Ile Phe Pro Pro Val 
            20                  25                  30          


Val Asn Ile Thr Trp Leu Ser Asn Gly Gln Ser Val Thr Glu Gly Val 
        35                  40                  45              


Ser Glu Thr Ser Phe Leu Ser Lys Ser Asp His Ser Phe Phe Lys Ile 
    50                  55                  60                  


Ser Tyr Leu Thr Phe Leu Pro Ser Ala Asp Glu Ile Tyr Asp Cys Lys 
65                  70                  75                  80  


Val Glu His Trp Gly Leu Asp Gln Pro Leu Leu Lys His Trp 
                85                  90                  


<210>  119
<211>  181
<212>  PRT
<213>  Homo sapiens

<400>  119

Glu Asp Ile Val Ala Asp His Val Ala Ser Tyr Gly Val Asn Phe Tyr 
1               5                   10                  15      


Gln Ser His Gly Pro Ser Gly Gln Tyr Thr His Glu Phe Asp Gly Asp 
            20                  25                  30          


Glu Glu Phe Tyr Val Asp Leu Glu Thr Lys Glu Thr Val Trp Gln Leu 
        35                  40                  45              


Pro Met Phe Ser Lys Phe Ile Ser Phe Asp Pro Gln Ser Ala Leu Arg 
    50                  55                  60                  


Asn Met Ala Val Gly Lys His Thr Leu Glu Phe Met Met Arg Gln Ser 
65                  70                  75                  80  


Asn Ser Thr Ala Ala Thr Asn Glu Val Pro Glu Val Thr Val Phe Ser 
                85                  90                  95      


Lys Phe Pro Val Thr Leu Gly Gln Pro Asn Thr Leu Ile Cys Leu Val 
            100                 105                 110         


Asp Asn Ile Phe Pro Pro Val Val Asn Ile Thr Trp Leu Ser Asn Gly 
        115                 120                 125             


His Ser Val Thr Glu Gly Val Ser Glu Thr Ser Phe Leu Ser Lys Ser 
    130                 135                 140                 


Asp His Ser Phe Phe Lys Ile Ser Tyr Leu Thr Phe Leu Pro Ser Ala 
145                 150                 155                 160 


Asp Glu Ile Tyr Asp Cys Lys Val Glu His Trp Gly Leu Asp Glu Pro 
                165                 170                 175     


Leu Leu Lys His Trp 
            180     


<210>  120
<211>  87
<212>  PRT
<213>  Homo sapiens

<400>  120

Glu Asp Ile Val Ala Asp His Val Ala Ser Tyr Gly Val Asn Phe Tyr 
1               5                   10                  15      


Gln Ser His Gly Pro Ser Gly Gln Tyr Thr His Glu Phe Asp Gly Asp 
            20                  25                  30          


Glu Glu Phe Tyr Val Asp Leu Glu Thr Lys Glu Thr Val Trp Gln Leu 
        35                  40                  45              


Pro Met Phe Ser Lys Phe Ile Ser Phe Asp Pro Gln Ser Ala Leu Arg 
    50                  55                  60                  


Asn Met Ala Val Gly Lys His Thr Leu Glu Phe Met Met Arg Gln Ser 
65                  70                  75                  80  


Asn Ser Thr Ala Ala Thr Asn 
                85          


<210>  121
<211>  94
<212>  PRT
<213>  Homo sapiens

<400>  121

Glu Val Pro Glu Val Thr Val Phe Ser Lys Phe Pro Val Thr Leu Gly 
1               5                   10                  15      


Gln Pro Asn Thr Leu Ile Cys Leu Val Asp Asn Ile Phe Pro Pro Val 
            20                  25                  30          


Val Asn Ile Thr Trp Leu Ser Asn Gly His Ser Val Thr Glu Gly Val 
        35                  40                  45              


Ser Glu Thr Ser Phe Leu Ser Lys Ser Asp His Ser Phe Phe Lys Ile 
    50                  55                  60                  


Ser Tyr Leu Thr Phe Leu Pro Ser Ala Asp Glu Ile Tyr Asp Cys Lys 
65                  70                  75                  80  


Val Glu His Trp Gly Leu Asp Glu Pro Leu Leu Lys His Trp 
                85                  90                  


<210>  122
<211>  199
<212>  PRT
<213>  Homo sapiens

<400>  122

Gly Asp Thr Arg Pro Arg Phe Leu Glu Gln Val Lys His Glu Cys His 
1               5                   10                  15      


Phe Phe Asn Gly Thr Glu Arg Val Arg Phe Leu Asp Arg Tyr Phe Tyr 
            20                  25                  30          


His Gln Glu Glu Tyr Val Arg Phe Asp Ser Asp Val Gly Glu Tyr Arg 
        35                  40                  45              


Ala Val Thr Glu Leu Gly Arg Pro Asp Ala Glu Tyr Trp Asn Ser Gln 
    50                  55                  60                  


Lys Asp Leu Leu Glu Gln Lys Arg Ala Ala Val Asp Thr Tyr Cys Arg 
65                  70                  75                  80  


His Asn Tyr Gly Val Gly Glu Ser Phe Thr Val Gln Arg Arg Val Tyr 
                85                  90                  95      


Pro Glu Val Thr Val Tyr Pro Ala Lys Thr Gln Pro Leu Gln His His 
            100                 105                 110         


Asn Leu Leu Val Cys Ser Val Asn Gly Phe Tyr Pro Ala Ser Ile Glu 
        115                 120                 125             


Val Arg Trp Phe Arg Asn Gly Gln Glu Glu Lys Thr Gly Val Val Ser 
    130                 135                 140                 


Thr Gly Leu Ile Gln Asn Gly Asp Trp Thr Phe Gln Thr Leu Val Met 
145                 150                 155                 160 


Leu Glu Thr Val Pro Arg Ser Gly Glu Val Tyr Thr Cys Gln Val Glu 
                165                 170                 175     


His Pro Ser Leu Thr Ser Pro Leu Thr Val Glu Trp Arg Ala Arg Ser 
            180                 185                 190         


Glu Ser Ala Gln Ser Lys Met 
        195                 


<210>  123
<211>  94
<212>  PRT
<213>  Homo sapiens

<400>  123

Asp Thr Arg Pro Arg Phe Leu Glu Gln Val Lys His Glu Cys His Phe 
1               5                   10                  15      


Phe Asn Gly Thr Glu Arg Val Arg Phe Leu Asp Arg Tyr Phe Tyr His 
            20                  25                  30          


Gln Glu Glu Tyr Val Arg Phe Asp Ser Asp Val Gly Glu Tyr Arg Ala 
        35                  40                  45              


Val Thr Glu Leu Gly Arg Pro Asp Ala Glu Tyr Trp Asn Ser Gln Lys 
    50                  55                  60                  


Asp Leu Leu Glu Gln Lys Arg Ala Ala Val Asp Thr Tyr Cys Arg His 
65                  70                  75                  80  


Asn Tyr Gly Val Gly Glu Ser Phe Thr Val Gln Arg Arg Val 
                85                  90                  


<210>  124
<211>  95
<212>  PRT
<213>  Homo sapiens

<400>  124

Gly Asp Thr Arg Cys Arg Phe Leu Glu Gln Val Lys His Glu Cys His 
1               5                   10                  15      


Phe Phe Asn Gly Thr Glu Arg Val Arg Phe Leu Asp Arg Tyr Phe Tyr 
            20                  25                  30          


His Gln Glu Glu Tyr Val Arg Phe Asp Ser Asp Val Gly Glu Tyr Arg 
        35                  40                  45              


Ala Val Thr Glu Leu Gly Arg Pro Asp Ala Glu Tyr Trp Asn Ser Gln 
    50                  55                  60                  


Lys Asp Leu Leu Glu Gln Lys Arg Ala Ala Val Asp Thr Tyr Cys Arg 
65                  70                  75                  80  


His Asn Tyr Gly Val Gly Glu Ser Phe Thr Val Gln Arg Arg Val 
                85                  90                  95  


<210>  125
<211>  103
<212>  PRT
<213>  Homo sapiens

<400>  125

Tyr Pro Glu Val Thr Val Tyr Pro Ala Lys Thr Gln Pro Leu Gln His 
1               5                   10                  15      


His Asn Leu Leu Val Cys Ser Val Asn Gly Phe Tyr Pro Gly Ser Ile 
            20                  25                  30          


Glu Val Arg Trp Phe Arg Asn Gly Gln Glu Glu Lys Thr Gly Val Val 
        35                  40                  45              


Ser Thr Gly Leu Ile Gln Asn Gly Asp Trp Thr Phe Gln Thr Leu Val 
    50                  55                  60                  


Met Leu Glu Thr Val Pro Arg Ser Gly Glu Val Tyr Thr Cys Gln Val 
65                  70                  75                  80  


Glu His Pro Ser Leu Thr Ser Pro Leu Thr Val Glu Trp Arg Ala Arg 
                85                  90                  95      


Ser Glu Ser Ala Gln Ser Lys 
            100             


<210>  126
<211>  104
<212>  PRT
<213>  Homo sapiens

<400>  126

Tyr Pro Glu Val Thr Val Tyr Pro Ala Lys Thr Gln Pro Leu Gln His 
1               5                   10                  15      


His Asn Leu Leu Val Cys Ser Val Asn Gly Phe Tyr Pro Ala Ser Ile 
            20                  25                  30          


Glu Val Arg Trp Phe Arg Asn Gly Gln Glu Glu Lys Thr Gly Val Val 
        35                  40                  45              


Ser Thr Gly Leu Ile Gln Asn Gly Asp Cys Thr Phe Gln Thr Leu Val 
    50                  55                  60                  


Met Leu Glu Thr Val Pro Arg Ser Gly Glu Val Tyr Thr Cys Gln Val 
65                  70                  75                  80  


Glu His Pro Ser Leu Thr Ser Pro Leu Thr Val Glu Trp Arg Ala Arg 
                85                  90                  95      


Ser Glu Ser Ala Gln Ser Lys Met 
            100                 


<210>  127
<211>  197
<212>  PRT
<213>  Homo sapiens

<400>  127

Asp Thr Arg Pro Arg Phe Leu Glu Leu Arg Lys Ser Glu Cys His Phe 
1               5                   10                  15      


Phe Asn Gly Thr Glu Arg Val Arg Tyr Leu Asp Arg Tyr Phe His Asn 
            20                  25                  30          


Gln Glu Glu Phe Leu Arg Phe Asp Ser Asp Val Gly Glu Tyr Arg Ala 
        35                  40                  45              


Val Thr Glu Leu Gly Arg Pro Val Ala Glu Ser Trp Asn Ser Gln Lys 
    50                  55                  60                  


Asp Leu Leu Glu Gln Lys Arg Gly Arg Val Asp Asn Tyr Cys Arg His 
65                  70                  75                  80  


Asn Tyr Gly Val Gly Glu Ser Phe Thr Val Gln Arg Arg Val His Pro 
                85                  90                  95      


Gln Val Thr Val Tyr Pro Ala Lys Thr Gln Pro Leu Gln His His Asn 
            100                 105                 110         


Leu Leu Val Cys Ser Val Ser Gly Phe Tyr Pro Gly Ser Ile Glu Val 
        115                 120                 125             


Arg Trp Phe Arg Asn Gly Gln Glu Glu Lys Ala Gly Val Val Ser Thr 
    130                 135                 140                 


Gly Leu Ile Gln Asn Gly Asp Trp Thr Phe Gln Thr Leu Val Met Leu 
145                 150                 155                 160 


Glu Thr Val Pro Arg Ser Gly Glu Val Tyr Thr Cys Gln Val Glu His 
                165                 170                 175     


Pro Ser Val Thr Ser Ala Leu Thr Val Glu Trp Arg Ala Arg Ser Glu 
            180                 185                 190         


Ser Ala Gln Ser Lys 
        195         


<210>  128
<211>  29
<212>  PRT
<213>  Homo sapiens

<400>  128

Met Val Cys Leu Lys Leu Pro Gly Gly Ser Ser Leu Ala Ala Leu Thr 
1               5                   10                  15      


Val Thr Leu Met Val Leu Ser Ser Arg Leu Ala Phe Ala 
            20                  25                  


<210>  129
<211>  94
<212>  PRT
<213>  Homo sapiens

<400>  129

Asp Thr Arg Pro Arg Phe Leu Glu Leu Arg Lys Ser Glu Cys His Phe 
1               5                   10                  15      


Phe Asn Gly Thr Glu Arg Val Arg Tyr Leu Asp Arg Tyr Phe His Asn 
            20                  25                  30          


Gln Glu Glu Phe Leu Arg Phe Asp Ser Asp Val Gly Glu Tyr Arg Ala 
        35                  40                  45              


Val Thr Glu Leu Gly Arg Pro Val Ala Glu Ser Trp Asn Ser Gln Lys 
    50                  55                  60                  


Asp Leu Leu Glu Gln Lys Arg Gly Arg Val Asp Asn Tyr Cys Arg His 
65                  70                  75                  80  


Asn Tyr Gly Val Gly Glu Ser Phe Thr Val Gln Arg Arg Val 
                85                  90                  


<210>  130
<211>  103
<212>  PRT
<213>  Homo sapiens

<400>  130

His Pro Gln Val Thr Val Tyr Pro Ala Lys Thr Gln Pro Leu Gln His 
1               5                   10                  15      


His Asn Leu Leu Val Cys Ser Val Ser Gly Phe Tyr Pro Gly Ser Ile 
            20                  25                  30          


Glu Val Arg Trp Phe Arg Asn Gly Gln Glu Glu Lys Ala Gly Val Val 
        35                  40                  45              


Ser Thr Gly Leu Ile Gln Asn Gly Asp Trp Thr Phe Gln Thr Leu Val 
    50                  55                  60                  


Met Leu Glu Thr Val Pro Arg Ser Gly Glu Val Tyr Thr Cys Gln Val 
65                  70                  75                  80  


Glu His Pro Ser Val Thr Ser Ala Leu Thr Val Glu Trp Arg Ala Arg 
                85                  90                  95      


Ser Glu Ser Ala Gln Ser Lys 
            100             


<210>  131
<211>  19
<212>  PRT
<213>  Homo sapiens

<400>  131

Met Val Cys Leu Lys Leu Pro Gly Gly Ser Cys Met Ala Ala Leu Thr 
1               5                   10                  15      


Val Thr Leu 
            


<210>  132
<211>  105
<212>  PRT
<213>  Homo sapiens

<400>  132

Thr Val Leu Ser Ser Pro Leu Ala Leu Ala Gly Asp Thr Gln Pro Arg 
1               5                   10                  15      


Phe Leu Glu Gln Ala Lys Cys Glu Cys His Phe Leu Asn Gly Thr Glu 
            20                  25                  30          


Arg Val Trp Asn Leu Ile Arg Tyr Ile Tyr Asn Gln Glu Glu Tyr Ala 
        35                  40                  45              


Arg Tyr Asn Ser Asp Leu Gly Glu Tyr Gln Ala Val Thr Glu Leu Gly 
    50                  55                  60                  


Arg Pro Asp Ala Glu Tyr Trp Asn Ser Gln Lys Asp Leu Leu Glu Arg 
65                  70                  75                  80  


Arg Arg Ala Glu Val Asp Thr Tyr Cys Arg Tyr Asn Tyr Gly Val Val 
                85                  90                  95      


Glu Ser Phe Thr Val Gln Arg Arg Val 
            100                 105 


<210>  133
<211>  103
<212>  PRT
<213>  Homo sapiens

<400>  133

Gln Pro Lys Val Thr Val Tyr Pro Ser Lys Thr Gln Pro Leu Gln His 
1               5                   10                  15      


His Asn Leu Leu Val Cys Ser Val Asn Gly Phe Tyr Pro Gly Ser Ile 
            20                  25                  30          


Glu Val Arg Trp Phe Arg Asn Gly Gln Glu Glu Lys Ala Gly Val Val 
        35                  40                  45              


Ser Thr Gly Leu Ile Gln Asn Gly Asp Trp Thr Phe Gln Thr Leu Val 
    50                  55                  60                  


Met Leu Glu Thr Val Pro Arg Ser Gly Glu Val Tyr Thr Cys Gln Val 
65                  70                  75                  80  


Glu His Pro Ser Met Met Ser Pro Leu Thr Val Gln Trp Ser Ala Arg 
                85                  90                  95      


Ser Glu Ser Ala Gln Ser Lys 
            100             


<210>  134
<211>  105
<212>  PRT
<213>  Homo sapiens

<400>  134

Met Val Leu Ser Ser Pro Leu Ala Leu Ala Gly Asp Thr Arg Pro Arg 
1               5                   10                  15      


Phe Leu Gln Gln Asp Lys Tyr Glu Cys His Phe Phe Asn Gly Thr Glu 
            20                  25                  30          


Arg Val Arg Phe Leu His Arg Asp Ile Tyr Asn Gln Glu Glu Asp Leu 
        35                  40                  45              


Arg Phe Asp Ser Asp Val Gly Glu Tyr Arg Ala Val Thr Glu Leu Gly 
    50                  55                  60                  


Arg Pro Asp Ala Glu Tyr Trp Asn Ser Gln Lys Asp Phe Leu Glu Asp 
65                  70                  75                  80  


Arg Arg Ala Ala Val Asp Thr Tyr Cys Arg His Asn Tyr Gly Val Gly 
                85                  90                  95      


Glu Ser Phe Thr Val Gln Arg Arg Val 
            100                 105 


<210>  135
<211>  102
<212>  PRT
<213>  Homo sapiens

<400>  135

Glu Pro Lys Val Thr Val Tyr Pro Ala Arg Thr Gln Thr Leu Gln His 
1               5                   10                  15      


His Asn Leu Leu Val Cys Ser Val Asn Gly Phe Tyr Pro Gly Ser Ile 
            20                  25                  30          


Glu Val Arg Trp Phe Arg Asn Ser Gln Glu Glu Lys Ala Gly Val Val 
        35                  40                  45              


Ser Thr Gly Leu Ile Gln Asn Gly Asp Trp Thr Phe Gln Thr Leu Val 
    50                  55                  60                  


Met Leu Glu Thr Val Pro Arg Ser Gly Glu Val Tyr Thr Cys Gln Val 
65                  70                  75                  80  


Glu His Pro Ser Val Thr Ser Pro Leu Thr Val Glu Trp Arg Ala Gln 
                85                  90                  95      


Ser Glu Ser Ala Gln Ser 
            100         


<210>  136
<211>  94
<212>  PRT
<213>  Homo sapiens

<400>  136

Gly Gly Phe Val Ala His Val Glu Ser Thr Cys Leu Leu Asp Asp Ala 
1               5                   10                  15      


Gly Thr Pro Lys Asp Phe Thr Tyr Cys Ile Ser Phe Asn Lys Asp Leu 
            20                  25                  30          


Leu Thr Cys Trp Asp Pro Glu Glu Asn Lys Met Ala Pro Cys Glu Phe 
        35                  40                  45              


Gly Val Leu Asn Ser Leu Ala Asn Val Leu Ser Gln His Leu Asn Gln 
    50                  55                  60                  


Lys Asp Thr Leu Met Gln Arg Leu Arg Asn Gly Leu Gln Asn Cys Ala 
65                  70                  75                  80  


Thr His Thr Gln Pro Phe Trp Gly Ser Leu Thr Asn Arg Thr 
                85                  90                  


<210>  137
<211>  95
<212>  PRT
<213>  Homo sapiens

<400>  137

Arg Pro Pro Ser Val Gln Val Ala Lys Thr Thr Pro Phe Asn Thr Arg 
1               5                   10                  15      


Glu Pro Val Met Leu Ala Cys Tyr Val Trp Gly Phe Tyr Pro Ala Glu 
            20                  25                  30          


Val Thr Ile Thr Trp Arg Lys Asn Gly Lys Leu Val Met Pro His Ser 
        35                  40                  45              


Ser Ala His Lys Thr Ala Gln Pro Asn Gly Asp Trp Thr Tyr Gln Thr 
    50                  55                  60                  


Leu Ser His Leu Ala Leu Thr Pro Ser Tyr Gly Asp Thr Tyr Thr Cys 
65                  70                  75                  80  


Val Val Glu His Thr Gly Ala Pro Glu Pro Ile Leu Arg Asp Trp 
                85                  90                  95  


<210>  138
<211>  94
<212>  PRT
<213>  Homo sapiens

<400>  138

Thr Asp Ser Pro Glu Asp Phe Val Ile Gln Ala Lys Ala Asp Cys Tyr 
1               5                   10                  15      


Phe Thr Asn Gly Thr Glu Lys Val Gln Phe Val Val Arg Phe Ile Phe 
            20                  25                  30          


Asn Leu Glu Glu Tyr Val Arg Phe Asp Ser Asp Val Gly Met Phe Val 
        35                  40                  45              


Ala Leu Thr Lys Leu Gly Gln Pro Asp Ala Glu Gln Trp Asn Ser Arg 
    50                  55                  60                  


Leu Asp Leu Leu Glu Arg Ser Arg Gln Ala Val Asp Gly Val Cys Arg 
65                  70                  75                  80  


His Asn Tyr Arg Leu Gly Ala Pro Phe Thr Val Gly Arg Lys 
                85                  90                  


<210>  139
<211>  94
<212>  PRT
<213>  Homo sapiens

<400>  139

Val Gln Pro Glu Val Thr Val Tyr Pro Glu Arg Thr Pro Leu Leu His 
1               5                   10                  15      


Gln His Asn Leu Leu His Cys Ser Val Thr Gly Phe Tyr Pro Gly Asp 
            20                  25                  30          


Ile Lys Ile Lys Trp Phe Leu Asn Gly Gln Glu Glu Arg Ala Gly Val 
        35                  40                  45              


Met Ser Thr Gly Pro Ile Arg Asn Gly Asp Trp Thr Phe Gln Thr Val 
    50                  55                  60                  


Val Met Leu Glu Met Thr Pro Glu Leu Gly His Val Tyr Thr Cys Leu 
65                  70                  75                  80  


Val Asp His Ser Ser Leu Leu Ser Pro Val Ser Val Glu Trp 
                85                  90                  


<210>  140
<211>  186
<212>  PRT
<213>  Homo sapiens

<400>  140

Arg Ala Thr Pro Glu Asn Tyr Leu Phe Gln Gly Arg Gln Glu Cys Tyr 
1               5                   10                  15      


Ala Phe Asn Gly Thr Gln Arg Phe Leu Glu Arg Tyr Ile Tyr Asn Arg 
            20                  25                  30          


Glu Glu Phe Ala Arg Phe Asp Ser Asp Val Gly Glu Phe Arg Ala Val 
        35                  40                  45              


Thr Glu Leu Gly Arg Pro Ala Ala Glu Tyr Trp Asn Ser Gln Lys Asp 
    50                  55                  60                  


Ile Leu Glu Glu Lys Arg Ala Val Pro Asp Arg Met Cys Arg His Asn 
65                  70                  75                  80  


Tyr Glu Leu Gly Gly Pro Met Thr Leu Gln Arg Arg Val Gln Pro Arg 
                85                  90                  95      


Val Asn Val Ser Pro Ser Lys Lys Gly Pro Leu Gln His His Asn Leu 
            100                 105                 110         


Leu Val Cys His Val Thr Asp Phe Tyr Pro Gly Ser Ile Gln Val Arg 
        115                 120                 125             


Trp Phe Leu Asn Gly Gln Glu Glu Thr Ala Gly Val Val Ser Thr Asn 
    130                 135                 140                 


Leu Ile Arg Asn Gly Asp Trp Thr Phe Gln Ile Leu Val Met Leu Glu 
145                 150                 155                 160 


Met Thr Pro Gln Gln Gly Asp Val Tyr Thr Cys Gln Val Glu His Thr 
                165                 170                 175     


Ser Leu Asp Ser Pro Val Thr Val Glu Trp 
            180                 185     


<210>  141
<211>  92
<212>  PRT
<213>  Homo sapiens

<400>  141

Arg Ala Thr Pro Glu Asn Tyr Leu Phe Gln Gly Arg Gln Glu Cys Tyr 
1               5                   10                  15      


Ala Phe Asn Gly Thr Gln Arg Phe Leu Glu Arg Tyr Ile Tyr Asn Arg 
            20                  25                  30          


Glu Glu Phe Ala Arg Phe Asp Ser Asp Val Gly Glu Phe Arg Ala Val 
        35                  40                  45              


Thr Glu Leu Gly Arg Pro Ala Ala Glu Tyr Trp Asn Ser Gln Lys Asp 
    50                  55                  60                  


Ile Leu Glu Glu Lys Arg Ala Val Pro Asp Arg Met Cys Arg His Asn 
65                  70                  75                  80  


Tyr Glu Leu Gly Gly Pro Met Thr Leu Gln Arg Arg 
                85                  90          


<210>  142
<211>  94
<212>  PRT
<213>  Homo sapiens

<400>  142

Val Gln Pro Arg Val Asn Val Ser Pro Ser Lys Lys Gly Pro Leu Gln 
1               5                   10                  15      


His His Asn Leu Leu Val Cys His Val Thr Asp Phe Tyr Pro Gly Ser 
            20                  25                  30          


Ile Gln Val Arg Trp Phe Leu Asn Gly Gln Glu Glu Thr Ala Gly Val 
        35                  40                  45              


Val Ser Thr Asn Leu Ile Arg Asn Gly Asp Trp Thr Phe Gln Ile Leu 
    50                  55                  60                  


Val Met Leu Glu Met Thr Pro Gln Gln Gly Asp Val Tyr Thr Cys Gln 
65                  70                  75                  80  


Val Glu His Thr Ser Leu Asp Ser Pro Val Thr Val Glu Trp 
                85                  90                  


<210>  143
<211>  94
<212>  PRT
<213>  Homo sapiens

<400>  143

Arg Asp Ser Pro Glu Asp Phe Val Phe Gln Phe Lys Gly Met Cys Tyr 
1               5                   10                  15      


Phe Thr Asn Gly Thr Glu Arg Val Arg Leu Val Thr Arg Tyr Ile Tyr 
            20                  25                  30          


Asn Arg Glu Glu Tyr Ala Arg Phe Asp Ser Asp Val Gly Val Tyr Arg 
        35                  40                  45              


Ala Val Thr Pro Gln Gly Arg Pro Asp Ala Glu Tyr Trp Asn Ser Gln 
    50                  55                  60                  


Lys Glu Val Leu Glu Gly Thr Arg Ala Glu Leu Asp Thr Val Cys Arg 
65                  70                  75                  80  


His Asn Tyr Glu Val Ala Phe Arg Gly Ile Leu Gln Arg Arg 
                85                  90                  


<210>  144
<211>  94
<212>  PRT
<213>  Homo sapiens

<400>  144

Val Glu Pro Thr Val Thr Ile Ser Pro Ser Arg Thr Glu Ala Leu Asn 
1               5                   10                  15      


His His Asn Leu Leu Val Cys Ser Val Thr Asp Phe Tyr Pro Gly Gln 
            20                  25                  30          


Ile Lys Val Arg Trp Phe Arg Asn Asp Gln Glu Glu Thr Ala Gly Val 
        35                  40                  45              


Val Ser Thr Pro Leu Ile Arg Asn Gly Asp Trp Thr Phe Gln Ile Leu 
    50                  55                  60                  


Val Met Leu Glu Met Thr Pro Gln Arg Gly Asp Val Tyr Thr Cys His 
65                  70                  75                  80  


Val Glu His Pro Ser Leu Gln Ser Pro Ile Thr Val Glu Trp 
                85                  90                  


<210>  145
<211>  182
<212>  PRT
<213>  Homo sapiens

<400>  145

Asp Phe Leu Val Gln Phe Lys Gly Met Cys Tyr Phe Thr Asn Gly Thr 
1               5                   10                  15      


Glu Arg Val Arg Gly Val Ala Arg Tyr Ile Tyr Asn Arg Glu Glu Tyr 
            20                  25                  30          


Gly Arg Phe Asp Ser Asp Val Gly Glu Phe Gln Ala Val Thr Glu Leu 
        35                  40                  45              


Gly Arg Ser Ile Glu Asp Trp Asn Asn Tyr Lys Asp Phe Leu Glu Gln 
    50                  55                  60                  


Glu Arg Ala Ala Val Asp Lys Val Cys Arg His Asn Tyr Glu Ala Glu 
65                  70                  75                  80  


Leu Arg Thr Thr Leu Gln Arg Gln Val Glu Pro Thr Val Thr Ile Ser 
                85                  90                  95      


Pro Ser Arg Thr Glu Ala Leu Asn His His Asn Leu Leu Val Cys Ser 
            100                 105                 110         


Val Thr Asp Phe Tyr Pro Ala Gln Ile Lys Val Arg Trp Phe Arg Asn 
        115                 120                 125             


Asp Gln Glu Glu Thr Ala Gly Val Val Ser Thr Ser Leu Ile Arg Asn 
    130                 135                 140                 


Gly Asp Trp Thr Phe Gln Ile Leu Val Met Leu Glu Ile Thr Pro Gln 
145                 150                 155                 160 


Arg Gly Asp Ile Tyr Thr Cys Gln Val Glu His Pro Ser Leu Gln Ser 
                165                 170                 175     


Pro Ile Thr Val Glu Trp 
            180         


<210>  146
<211>  93
<212>  PRT
<213>  Homo sapiens

<400>  146

Asp Phe Leu Val Gln Phe Lys Gly Met Cys Tyr Phe Thr Asn Gly Thr 
1               5                   10                  15      


Glu Arg Val Arg Gly Val Ala Arg Tyr Ile Tyr Asn Arg Glu Glu Tyr 
            20                  25                  30          


Gly Arg Phe Asp Ser Asp Val Gly Glu Phe Gln Ala Val Thr Glu Leu 
        35                  40                  45              


Gly Arg Ser Ile Glu Asp Trp Asn Asn Tyr Lys Asp Phe Leu Glu Gln 
    50                  55                  60                  


Glu Arg Ala Ala Val Asp Lys Val Cys Arg His Asn Tyr Glu Ala Glu 
65                  70                  75                  80  


Leu Arg Thr Thr Leu Gln Arg Gln Val Glu Pro Thr Val 
                85                  90              


<210>  147
<211>  89
<212>  PRT
<213>  Homo sapiens

<400>  147

Thr Ile Ser Pro Ser Arg Thr Glu Ala Leu Asn His His Asn Leu Leu 
1               5                   10                  15      


Val Cys Ser Val Thr Asp Phe Tyr Pro Ala Gln Ile Lys Val Arg Trp 
            20                  25                  30          


Phe Arg Asn Asp Gln Glu Glu Thr Ala Gly Val Val Ser Thr Ser Leu 
        35                  40                  45              


Ile Arg Asn Gly Asp Trp Thr Phe Gln Ile Leu Val Met Leu Glu Ile 
    50                  55                  60                  


Thr Pro Gln Arg Gly Asp Ile Tyr Thr Cys Gln Val Glu His Pro Ser 
65                  70                  75                  80  


Leu Gln Ser Pro Ile Thr Val Glu Trp 
                85                  


<210>  148
<211>  20
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Peptide suitable for use as a linker.

<400>  148

Gly Cys Gly Gly Ser Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser Gly 
1               5                   10                  15      


Gly Gly Gly Ser 
            20  


<210>  149
<211>  5
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Peptide suitable for use as a linker.

<400>  149

Gly Gly Gly Gly Ser 
1               5   


<210>  150
<211>  33
<212>  PRT
<213>  Homo sapiens

<400>  150

Arg Met Lys Gln Ile Glu Asp Lys Ile Glu Glu Ile Leu Ser Lys Ile 
1               5                   10                  15      


Tyr His Ile Glu Asn Glu Ile Ala Arg Ile Lys Lys Leu Ile Gly Glu 
            20                  25                  30          


Arg 
    


<210>  151
<211>  32
<212>  PRT
<213>  Homo sapiens

<400>  151

Leu Ser Ser Ile Glu Lys Lys Gln Glu Glu Gln Thr Ser Trp Leu Ile 
1               5                   10                  15      


Trp Ile Ser Asn Glu Leu Thr Leu Ile Arg Asn Glu Leu Ala Gln Ser 
            20                  25                  30          


<210>  152
<211>  31
<212>  PRT
<213>  Homo sapiens

<400>  152

Leu Ser Ser Ile Glu Lys Lys Leu Glu Glu Ile Thr Ser Gln Leu Ile 
1               5                   10                  15      


Gln Ile Ser Asn Glu Leu Thr Leu Ile Arg Asn Glu Leu Ala Gln 
            20                  25                  30      


<210>  153
<211>  31
<212>  PRT
<213>  Homo sapiens

<400>  153

Leu Ser Ser Ile Glu Lys Lys Leu Glu Glu Ile Thr Ser Gln Leu Ile 
1               5                   10                  15      


Gln Ile Arg Asn Glu Leu Thr Leu Ile Arg Asn Glu Leu Ala Gln 
            20                  25                  30      


<210>  154
<211>  31
<212>  PRT
<213>  Homo sapiens

<400>  154

Leu Ser Ser Ile Glu Lys Lys Leu Glu Glu Ile Thr Ser Gln Leu Gln 
1               5                   10                  15      


Gln Ile Arg Asn Glu Leu Thr Leu Ile Arg Asn Glu Leu Ala Gln 
            20                  25                  30      


<210>  155
<211>  31
<212>  PRT
<213>  Homo sapiens

<400>  155

Leu Ser Ser Leu Glu Lys Lys Leu Glu Glu Leu Thr Ser Gln Leu Ile 
1               5                   10                  15      


Gln Leu Arg Asn Glu Leu Thr Leu Leu Arg Asn Glu Leu Ala Gln 
            20                  25                  30      


<210>  156
<211>  31
<212>  PRT
<213>  Homo sapiens

<400>  156

Ile Ser Ser Leu Glu Lys Lys Ile Glu Glu Leu Thr Ser Gln Ile Gln 
1               5                   10                  15      


Gln Leu Arg Asn Glu Ile Thr Leu Leu Arg Asn Glu Ile Ala Gln 
            20                  25                  30      


<210>  157
<211>  47
<212>  PRT
<213>  Homo sapiens

<400>  157

Leu Glu Ile Glu Ala Ala Phe Leu Glu Arg Glu Asn Thr Ala Leu Glu 
1               5                   10                  15      


Thr Arg Val Ala Glu Leu Arg Gln Arg Val Gln Arg Leu Arg Asn Arg 
            20                  25                  30          


Val Ser Gln Tyr Arg Thr Arg Tyr Gly Pro Leu Gly Gly Gly Lys 
        35                  40                  45          


<210>  158
<211>  31
<212>  PRT
<213>  Homo sapiens

<400>  158

Leu Lys Ser Val Glu Asn Arg Leu Ala Val Val Glu Asn Gln Leu Lys 
1               5                   10                  15      


Thr Val Ile Glu Glu Leu Lys Thr Val Lys Asp Leu Leu Ser Asn 
            20                  25                  30      


<210>  159
<211>  31
<212>  PRT
<213>  Homo sapiens

<400>  159

Leu Ala Arg Ile Glu Glu Lys Leu Lys Thr Ile Lys Ala Gln Leu Ser 
1               5                   10                  15      


Glu Ile Ala Ser Thr Leu Asn Met Ile Arg Glu Gln Leu Ala Gln 
            20                  25                  30      


<210>  160
<211>  31
<212>  PRT
<213>  Homo sapiens

<400>  160

Val Ser Arg Leu Glu Glu Lys Val Lys Thr Leu Lys Ser Gln Val Thr 
1               5                   10                  15      


Glu Leu Ala Ser Thr Val Ser Leu Leu Arg Glu Gln Val Ala Gln 
            20                  25                  30      


<210>  161
<211>  30
<212>  PRT
<213>  Homo sapiens

<400>  161

Ile Gln Ser Glu Lys Lys Ile Glu Asp Ile Ser Ser Leu Ile Gly Gln 
1               5                   10                  15      


Ile Gln Ser Glu Ile Thr Leu Ile Arg Asn Glu Ile Ala Gln 
            20                  25                  30  


<210>  162
<211>  31
<212>  PRT
<213>  Homo sapiens

<400>  162

Leu Met Ser Leu Glu Lys Lys Leu Glu Glu Leu Thr Gln Thr Leu Met 
1               5                   10                  15      


Gln Leu Gln Asn Glu Leu Ser Met Leu Lys Asn Glu Leu Ala Gln 
            20                  25                  30      


<210>  163
<211>  18
<212>  PRT
<213>  Homo sapiens

<400>  163

Val Asp Leu Glu Gly Ser Thr Ser Asn Gly Arg Gln Cys Ala Gly Ile 
1               5                   10                  15      


Arg Leu 
        


<210>  164
<211>  27
<212>  PRT
<213>  Homo sapiens

<400>  164

Glu Asp Asp Val Thr Thr Thr Glu Glu Leu Ala Pro Ala Leu Val Pro 
1               5                   10                  15      


Pro Pro Lys Gly Thr Cys Ala Gly Trp Met Ala 
            20                  25          


<210>  165
<211>  27
<212>  PRT
<213>  Homo sapiens

<400>  165

Gly His Asp Gln Glu Thr Thr Thr Gln Gly Pro Gly Val Leu Leu Pro 
1               5                   10                  15      


Leu Pro Lys Gly Ala Cys Thr Gly Gln Met Ala 
            20                  25          


<210>  166
<211>  64
<212>  PRT
<213>  Homo sapiens

<400>  166

Val Thr Ala Phe Ser Asn Met Asp Asp Met Leu Gln Lys Ala His Leu 
1               5                   10                  15      


Val Ile Glu Gly Thr Phe Ile Tyr Leu Arg Asp Ser Thr Glu Phe Phe 
            20                  25                  30          


Ile Arg Val Arg Asp Gly Trp Lys Lys Leu Gln Leu Gly Glu Leu Ile 
        35                  40                  45              


Pro Ile Pro Ala Asp Ser Pro Pro Pro Pro Ala Leu Ser Ser Asn Pro 
    50                  55                  60                  


<210>  167
<211>  112
<212>  PRT
<213>  Homo sapiens

<400>  167

Ala Leu Asp Thr Asn Tyr Cys Phe Ser Ser Thr Glu Lys Asn Cys Cys 
1               5                   10                  15      


Val Arg Gln Leu Tyr Ile Asp Phe Arg Lys Asp Leu Gly Trp Lys Trp 
            20                  25                  30          


Ile His Glu Pro Lys Gly Tyr His Ala Asn Phe Cys Leu Gly Pro Cys 
        35                  40                  45              


Pro Tyr Ile Trp Ser Leu Asp Thr Gln Tyr Ser Lys Val Leu Ala Leu 
    50                  55                  60                  


Tyr Asn Gln His Asn Pro Gly Ala Ser Ala Ala Pro Cys Cys Val Pro 
65                  70                  75                  80  


Gln Ala Leu Glu Pro Leu Pro Ile Val Tyr Tyr Val Gly Arg Lys Pro 
                85                  90                  95      


Lys Val Glu Gln Leu Ser Asn Met Ile Val Arg Ser Cys Lys Cys Ser 
            100                 105                 110         


<210>  168
<211>  112
<212>  PRT
<213>  Homo sapiens

<400>  168

Ala Leu Asp Thr Asn Tyr Cys Phe Ser Ser Thr Glu Lys Asn Cys Cys 
1               5                   10                  15      


Val Arg Gln Leu Tyr Ile Asp Phe Arg Lys Asp Leu Gly Trp Lys Trp 
            20                  25                  30          


Ile His Glu Pro Lys Gly Tyr His Ala Asn Phe Cys Leu Gly Pro Cys 
        35                  40                  45              


Pro Tyr Ile Trp Ser Leu Asp Thr Gln Tyr Ser Lys Val Leu Ala Leu 
    50                  55                  60                  


Tyr Asn Gln His Asn Pro Gly Ala Ser Ala Ala Pro Ser Cys Val Pro 
65                  70                  75                  80  


Gln Ala Leu Glu Pro Leu Pro Ile Val Tyr Tyr Val Gly Arg Lys Pro 
                85                  90                  95      


Lys Val Glu Gln Leu Ser Asn Met Ile Val Arg Ser Cys Lys Cys Ser 
            100                 105                 110         


<210>  169
<211>  112
<212>  PRT
<213>  Homo sapiens

<400>  169

Ala Leu Asp Ala Ala Tyr Cys Phe Arg Asn Val Gln Asp Asn Cys Cys 
1               5                   10                  15      


Leu Arg Pro Leu Tyr Ile Asp Phe Lys Arg Asp Leu Gly Trp Lys Trp 
            20                  25                  30          


Ile His Glu Pro Lys Gly Tyr Asn Ala Asn Phe Cys Ala Gly Ala Cys 
        35                  40                  45              


Pro Tyr Leu Trp Ser Ser Asp Thr Gln His Ser Arg Val Leu Ser Leu 
    50                  55                  60                  


Tyr Asn Thr Ile Asn Pro Glu Ala Ser Ala Ser Pro Cys Cys Val Ser 
65                  70                  75                  80  


Gln Asp Leu Glu Pro Leu Thr Ile Leu Tyr Tyr Ile Gly Lys Thr Pro 
                85                  90                  95      


Lys Ile Glu Gln Leu Ser Asn Met Ile Val Lys Ser Cys Lys Cys Ser 
            100                 105                 110         


<210>  170
<211>  112
<212>  PRT
<213>  Homo sapiens

<400>  170

Ala Leu Asp Ala Ala Tyr Cys Phe Arg Asn Val Gln Asp Asn Cys Cys 
1               5                   10                  15      


Leu Arg Pro Leu Tyr Ile Asp Phe Lys Arg Asp Leu Gly Trp Lys Trp 
            20                  25                  30          


Ile His Glu Pro Lys Gly Tyr Asn Ala Asn Phe Cys Ala Gly Ala Cys 
        35                  40                  45              


Pro Tyr Leu Trp Ser Ser Asp Thr Gln His Ser Arg Val Leu Ser Leu 
    50                  55                  60                  


Tyr Asn Thr Ile Asn Pro Glu Ala Ser Ala Ser Pro Ser Cys Val Ser 
65                  70                  75                  80  


Gln Asp Leu Glu Pro Leu Thr Ile Leu Tyr Tyr Ile Gly Lys Thr Pro 
                85                  90                  95      


Lys Ile Glu Gln Leu Ser Asn Met Ile Val Lys Ser Cys Lys Cys Ser 
            100                 105                 110         


<210>  171
<211>  112
<212>  PRT
<213>  Homo sapiens

<400>  171

Ala Leu Asp Thr Asn Tyr Cys Phe Arg Asn Leu Glu Glu Asn Cys Cys 
1               5                   10                  15      


Val Arg Pro Leu Tyr Ile Asp Phe Arg Gln Asp Leu Gly Trp Lys Trp 
            20                  25                  30          


Val His Glu Pro Lys Gly Tyr Tyr Ala Asn Phe Cys Ser Gly Pro Cys 
        35                  40                  45              


Pro Tyr Leu Arg Ser Ala Asp Thr Thr His Ser Thr Val Leu Gly Leu 
    50                  55                  60                  


Tyr Asn Thr Leu Asn Pro Glu Ala Ser Ala Ser Pro Cys Cys Val Pro 
65                  70                  75                  80  


Gln Asp Leu Glu Pro Leu Thr Ile Leu Tyr Tyr Val Gly Arg Thr Pro 
                85                  90                  95      


Lys Val Glu Gln Leu Ser Asn Met Val Val Lys Ser Cys Lys Cys Ser 
            100                 105                 110         


<210>  172
<211>  112
<212>  PRT
<213>  Homo sapiens

<400>  172

Ala Leu Asp Thr Asn Tyr Cys Phe Arg Asn Leu Glu Glu Asn Cys Cys 
1               5                   10                  15      


Val Arg Pro Leu Tyr Ile Asp Phe Arg Gln Asp Leu Gly Trp Lys Trp 
            20                  25                  30          


Val His Glu Pro Lys Gly Tyr Tyr Ala Asn Phe Cys Ser Gly Pro Cys 
        35                  40                  45              


Pro Tyr Leu Arg Ser Ala Asp Thr Thr His Ser Thr Val Leu Gly Leu 
    50                  55                  60                  


Tyr Asn Thr Leu Asn Pro Glu Ala Ser Ala Ser Pro Ser Cys Val Pro 
65                  70                  75                  80  


Gln Asp Leu Glu Pro Leu Thr Ile Leu Tyr Tyr Val Gly Arg Thr Pro 
                85                  90                  95      


Lys Val Glu Gln Leu Ser Asn Met Val Val Lys Ser Cys Lys Cys Ser 
            100                 105                 110         


<210>  173
<211>  93
<212>  PRT
<213>  Homo sapiens

<400>  173

Leu Gln Cys Phe Cys His Leu Cys Thr Lys Asp Asn Phe Thr Cys Val 
1               5                   10                  15      


Thr Asp Gly Leu Cys Phe Val Ser Val Thr Glu Thr Thr Asp Lys Val 
            20                  25                  30          


Ile His Asn Ser Met Cys Ile Ala Glu Ile Asp Leu Ile Pro Arg Asp 
        35                  40                  45              


Arg Pro Phe Val Cys Ala Pro Ser Ser Lys Thr Gly Ser Val Thr Thr 
    50                  55                  60                  


Thr Tyr Cys Cys Asn Gln Asp His Cys Asn Lys Ile Glu Leu Pro Thr 
65                  70                  75                  80  


Thr Val Lys Ser Ser Pro Gly Leu Gly Pro Val Glu Leu 
                85                  90              


<210>  174
<211>  154
<212>  PRT
<213>  Homo sapiens

<400>  174

Ile Pro Pro His Val Gln Lys Ser Asp Val Glu Met Glu Ala Gln Lys 
1               5                   10                  15      


Asp Glu Ile Ile Cys Pro Ser Cys Asn Arg Thr Ala His Pro Leu Arg 
            20                  25                  30          


His Ile Asn Asn Asp Met Ile Val Thr Asp Asn Asn Gly Ala Val Lys 
        35                  40                  45              


Phe Pro Gln Leu Cys Lys Phe Cys Asp Val Arg Phe Ser Thr Cys Asp 
    50                  55                  60                  


Asn Gln Lys Ser Cys Met Ser Asn Cys Ser Ile Thr Ser Ile Cys Glu 
65                  70                  75                  80  


Lys Pro Gln Glu Val Cys Val Ala Val Trp Arg Lys Asn Asp Glu Asn 
                85                  90                  95      


Ile Thr Leu Glu Thr Val Cys His Asp Pro Lys Leu Pro Tyr His Asp 
            100                 105                 110         


Phe Ile Leu Glu Asp Ala Ala Ser Pro Lys Cys Ile Met Lys Glu Lys 
        115                 120                 125             


Lys Lys Pro Gly Glu Thr Phe Phe Met Cys Ser Cys Ser Ser Asp Glu 
    130                 135                 140                 


Cys Asn Asp Asn Ile Ile Phe Ser Glu Glu 
145                 150                 


<210>  175
<211>  143
<212>  PRT
<213>  Homo sapiens

<400>  175

Ile Pro Pro His Val Gln Lys Ser Val Asn Asn Asp Met Ile Val Thr 
1               5                   10                  15      


Asp Asn Asn Gly Ala Val Lys Phe Pro Gln Leu Cys Lys Phe Cys Asp 
            20                  25                  30          


Val Arg Phe Ser Thr Cys Asp Asn Gln Lys Ser Cys Met Ser Asn Cys 
        35                  40                  45              


Ser Ile Thr Ser Ile Cys Glu Lys Pro Gln Glu Val Cys Val Ala Val 
    50                  55                  60                  


Trp Arg Lys Asn Asp Glu Asn Ile Thr Leu Glu Thr Val Cys His Asp 
65                  70                  75                  80  


Pro Lys Leu Pro Tyr His Asp Phe Ile Leu Glu Asp Ala Ala Ser Pro 
                85                  90                  95      


Lys Cys Ile Met Lys Glu Lys Lys Lys Pro Gly Glu Thr Phe Phe Met 
            100                 105                 110         


Cys Ser Cys Ser Ser Asp Glu Cys Asn Asp Asn Ile Ile Phe Ser Glu 
        115                 120                 125             


Glu Tyr Asn Thr Ser Asn Pro Asp Leu Leu Leu Val Ile Phe Gln 
    130                 135                 140             


<210>  176
<211>  129
<212>  PRT
<213>  Homo sapiens

<400>  176

Ile Pro Pro His Val Gln Lys Ser Val Asn Asn Asp Met Ile Val Thr 
1               5                   10                  15      


Asp Asn Asn Gly Ala Val Lys Phe Pro Gln Leu Cys Lys Phe Cys Asp 
            20                  25                  30          


Val Arg Phe Ser Thr Cys Asp Asn Gln Lys Ser Cys Met Ser Asn Cys 
        35                  40                  45              


Ser Ile Thr Ser Ile Cys Glu Lys Pro Gln Glu Val Cys Val Ala Val 
    50                  55                  60                  


Trp Arg Lys Asn Asp Glu Asn Ile Thr Leu Glu Thr Val Cys His Asp 
65                  70                  75                  80  


Pro Lys Leu Pro Tyr His Asp Phe Ile Leu Glu Asp Ala Ala Ser Pro 
                85                  90                  95      


Lys Cys Ile Met Lys Glu Lys Lys Lys Pro Gly Glu Thr Phe Phe Met 
            100                 105                 110         


Cys Ser Cys Ser Ser Asp Glu Cys Asn Asp Asn Ile Ile Phe Ser Glu 
        115                 120                 125             


Glu 
    


<210>  177
<211>  114
<212>  PRT
<213>  Homo sapiens

<400>  177

Thr Asp Asn Asn Gly Ala Val Lys Phe Pro Gln Leu Cys Lys Phe Cys 
1               5                   10                  15      


Asp Val Arg Phe Ser Thr Cys Asp Asn Gln Lys Ser Cys Met Ser Asn 
            20                  25                  30          


Cys Ser Ile Thr Ser Ile Cys Glu Lys Pro Gln Glu Val Cys Val Ala 
        35                  40                  45              


Val Trp Arg Lys Asn Asp Glu Asn Ile Thr Leu Glu Thr Val Cys His 
    50                  55                  60                  


Asp Pro Lys Leu Pro Tyr His Asp Phe Ile Leu Glu Asp Ala Ala Ser 
65                  70                  75                  80  


Pro Lys Cys Ile Met Lys Glu Lys Lys Lys Pro Gly Glu Thr Phe Phe 
                85                  90                  95      


Met Cys Ser Cys Ser Ser Asp Glu Cys Asn Asp Asn Ile Ile Phe Ser 
            100                 105                 110         


Glu Glu 
        


<210>  178
<211>  104
<212>  PRT
<213>  Homo sapiens

<400>  178

Gln Leu Cys Lys Phe Cys Asp Val Arg Phe Ser Thr Cys Asp Asn Gln 
1               5                   10                  15      


Lys Ser Cys Met Ser Asn Cys Ser Ile Thr Ser Ile Cys Glu Lys Pro 
            20                  25                  30          


Gln Glu Val Cys Val Ala Val Trp Arg Lys Asn Asp Glu Asn Ile Thr 
        35                  40                  45              


Leu Glu Thr Val Cys His Asp Pro Lys Leu Pro Tyr His Asp Phe Ile 
    50                  55                  60                  


Leu Glu Asp Ala Ala Ser Pro Lys Cys Ile Met Lys Glu Lys Lys Lys 
65                  70                  75                  80  


Pro Gly Glu Thr Phe Phe Met Cys Ser Cys Ser Ser Asp Glu Cys Asn 
                85                  90                  95      


Asp Asn Ile Ile Phe Ser Glu Glu 
            100                 


<210>  179
<211>  112
<212>  PRT
<213>  Homo sapiens

<400>  179

Ser Gln Leu Cys Lys Phe Cys Asp Val Arg Phe Ser Thr Cys Asp Asn 
1               5                   10                  15      


Gln Lys Ser Cys Met Ser Asn Cys Ser Ile Thr Ser Ile Cys Glu Lys 
            20                  25                  30          


Pro Gln Glu Val Cys Val Ala Val Trp Arg Lys Asn Asp Glu Asn Ile 
        35                  40                  45              


Thr Leu Glu Thr Val Cys His Asp Pro Lys Leu Pro Tyr His Asp Phe 
    50                  55                  60                  


Ile Leu Glu Asp Ala Ala Ser Pro Lys Cys Ile Met Lys Glu Lys Lys 
65                  70                  75                  80  


Lys Pro Gly Glu Thr Phe Phe Met Cys Ser Cys Ser Ser Ala Glu Cys 
                85                  90                  95      


Asn Asp Asn Ile Ile Phe Ser Glu Glu Tyr Asn Thr Ser Asn Pro Asp 
            100                 105                 110         


<210>  180
<211>  112
<212>  PRT
<213>  Homo sapiens

<400>  180

Ala Leu Asp Thr Asn Tyr Cys Phe Arg Asn Leu Glu Glu Asn Cys Cys 
1               5                   10                  15      


Val Arg Pro Leu Tyr Ile Asp Phe Arg Gln Asp Leu Gly Trp Lys Trp 
            20                  25                  30          


Val His Glu Pro Lys Gly Tyr Tyr Ala Asn Phe Cys Ser Gly Pro Cys 
        35                  40                  45              


Pro Tyr Leu Arg Ser Ala Asp Thr Thr His Ser Thr Val Leu Gly Leu 
    50                  55                  60                  


Tyr Asn Thr Leu Asn Pro Glu Ala Ser Ala Ser Pro Ser Cys Val Pro 
65                  70                  75                  80  


Gln Asp Leu Glu Pro Leu Thr Ile Leu Tyr Tyr Val Gly Arg Thr Pro 
                85                  90                  95      


Lys Val Glu Gln Leu Ser Asn Met Val Val Lys Ser Cys Lys Cys Ser 
            100                 105                 110         


<210>  181
<211>  133
<212>  PRT
<213>  Homo sapiens

<400>  181

Ala Pro Thr Ser Ser Ser Thr Lys Lys Thr Gln Leu Gln Leu Glu His 
1               5                   10                  15      


Leu Leu Leu Asp Leu Gln Met Ile Leu Asn Gly Ile Asn Asn Tyr Lys 
            20                  25                  30          


Asn Pro Lys Leu Thr Arg Met Leu Thr Phe Lys Phe Tyr Met Pro Lys 
        35                  40                  45              


Lys Ala Thr Glu Leu Lys His Leu Gln Cys Leu Glu Glu Glu Leu Lys 
    50                  55                  60                  


Pro Leu Glu Glu Val Leu Asn Leu Ala Gln Ser Lys Asn Phe His Leu 
65                  70                  75                  80  


Arg Pro Arg Asp Leu Ile Ser Asn Ile Asn Val Ile Val Leu Glu Leu 
                85                  90                  95      


Lys Gly Ser Glu Thr Thr Phe Met Cys Glu Tyr Ala Asp Glu Thr Ala 
            100                 105                 110         


Thr Ile Val Glu Phe Leu Asn Arg Trp Ile Thr Phe Cys Gln Ser Ile 
        115                 120                 125             


Ile Ser Thr Leu Thr 
    130             


<210>  182
<211>  251
<212>  PRT
<213>  Homo sapiens

<400>  182

Glu Leu Cys Asp Asp Asp Pro Pro Glu Ile Pro His Ala Thr Phe Lys 
1               5                   10                  15      


Ala Met Ala Tyr Lys Glu Gly Thr Met Leu Asn Cys Glu Cys Lys Arg 
            20                  25                  30          


Gly Phe Arg Arg Ile Lys Ser Gly Ser Leu Tyr Met Leu Cys Thr Gly 
        35                  40                  45              


Asn Ser Ser His Ser Ser Trp Asp Asn Gln Cys Gln Cys Thr Ser Ser 
    50                  55                  60                  


Ala Thr Arg Asn Thr Thr Lys Gln Val Thr Pro Gln Pro Glu Glu Gln 
65                  70                  75                  80  


Lys Glu Arg Lys Thr Thr Glu Met Gln Ser Pro Met Gln Pro Val Asp 
                85                  90                  95      


Gln Ala Ser Leu Pro Gly His Cys Arg Glu Pro Pro Pro Trp Glu Asn 
            100                 105                 110         


Glu Ala Thr Glu Arg Ile Tyr His Phe Val Val Gly Gln Met Val Tyr 
        115                 120                 125             


Tyr Gln Cys Val Gln Gly Tyr Arg Ala Leu His Arg Gly Pro Ala Glu 
    130                 135                 140                 


Ser Val Cys Lys Met Thr His Gly Lys Thr Arg Trp Thr Gln Pro Gln 
145                 150                 155                 160 


Leu Ile Cys Thr Gly Glu Met Glu Thr Ser Gln Phe Pro Gly Glu Glu 
                165                 170                 175     


Lys Pro Gln Ala Ser Pro Glu Gly Arg Pro Glu Ser Glu Thr Ser Cys 
            180                 185                 190         


Leu Val Thr Thr Thr Asp Phe Gln Ile Gln Thr Glu Met Ala Ala Thr 
        195                 200                 205             


Met Glu Thr Ser Ile Phe Thr Thr Glu Tyr Gln Val Ala Val Ala Gly 
    210                 215                 220                 


Cys Val Phe Leu Leu Ile Ser Val Leu Leu Leu Ser Gly Leu Thr Trp 
225                 230                 235                 240 


Gln Arg Arg Gln Arg Lys Ser Arg Arg Thr Ile 
                245                 250     


<210>  183
<211>  524
<212>  PRT
<213>  Homo sapiens

<400>  183

Val Asn Gly Thr Ser Gln Phe Thr Cys Phe Tyr Asn Ser Arg Ala Asn 
1               5                   10                  15      


Ile Ser Cys Val Trp Ser Gln Asp Gly Ala Leu Gln Asp Thr Ser Cys 
            20                  25                  30          


Gln Val His Ala Trp Pro Asp Arg Arg Arg Trp Asn Gln Thr Cys Glu 
        35                  40                  45              


Leu Leu Pro Val Ser Gln Ala Ser Trp Ala Cys Asn Leu Ile Leu Gly 
    50                  55                  60                  


Ala Pro Asp Ser Gln Lys Leu Thr Thr Val Asp Ile Val Thr Leu Arg 
65                  70                  75                  80  


Val Leu Cys Arg Glu Gly Val Arg Trp Arg Val Met Ala Ile Gln Asp 
                85                  90                  95      


Phe Lys Pro Phe Glu Asn Leu Arg Leu Met Ala Pro Ile Ser Leu Gln 
            100                 105                 110         


Val Val His Val Glu Thr His Arg Cys Asn Ile Ser Trp Glu Ile Ser 
        115                 120                 125             


Gln Ala Ser His Tyr Phe Glu Arg His Leu Glu Phe Glu Ala Arg Thr 
    130                 135                 140                 


Leu Ser Pro Gly His Thr Trp Glu Glu Ala Pro Leu Leu Thr Leu Lys 
145                 150                 155                 160 


Gln Lys Gln Glu Trp Ile Cys Leu Glu Thr Leu Thr Pro Asp Thr Gln 
                165                 170                 175     


Tyr Glu Phe Gln Val Arg Val Lys Pro Leu Gln Gly Glu Phe Thr Thr 
            180                 185                 190         


Trp Ser Pro Trp Ser Gln Pro Leu Ala Phe Arg Thr Lys Pro Ala Ala 
        195                 200                 205             


Leu Gly Lys Asp Thr Ile Pro Trp Leu Gly His Leu Leu Val Gly Leu 
    210                 215                 220                 


Ser Gly Ala Phe Gly Phe Ile Ile Leu Val Tyr Leu Leu Ile Asn Cys 
225                 230                 235                 240 


Arg Asn Thr Gly Pro Trp Leu Lys Lys Val Leu Lys Cys Asn Thr Pro 
                245                 250                 255     


Asp Pro Ser Lys Phe Phe Ser Gln Leu Ser Ser Glu His Gly Gly Asp 
            260                 265                 270         


Val Gln Lys Trp Leu Ser Ser Pro Phe Pro Ser Ser Ser Phe Ser Pro 
        275                 280                 285             


Gly Gly Leu Ala Pro Glu Ile Ser Pro Leu Glu Val Leu Glu Arg Asp 
    290                 295                 300                 


Lys Val Thr Gln Leu Leu Leu Gln Gln Asp Lys Val Pro Glu Pro Ala 
305                 310                 315                 320 


Ser Leu Ser Ser Asn His Ser Leu Thr Ser Cys Phe Thr Asn Gln Gly 
                325                 330                 335     


Tyr Phe Phe Phe His Leu Pro Asp Ala Leu Glu Ile Glu Ala Cys Gln 
            340                 345                 350         


Val Tyr Phe Thr Tyr Asp Pro Tyr Ser Glu Glu Asp Pro Asp Glu Gly 
        355                 360                 365             


Val Ala Gly Ala Pro Thr Gly Ser Ser Pro Gln Pro Leu Gln Pro Leu 
    370                 375                 380                 


Ser Gly Glu Asp Asp Ala Tyr Cys Thr Phe Pro Ser Arg Asp Asp Leu 
385                 390                 395                 400 


Leu Leu Phe Ser Pro Ser Leu Leu Gly Gly Pro Ser Pro Pro Ser Thr 
                405                 410                 415     


Ala Pro Gly Gly Ser Gly Ala Gly Glu Glu Arg Met Pro Pro Ser Leu 
            420                 425                 430         


Gln Glu Arg Val Pro Arg Asp Trp Asp Pro Gln Pro Leu Gly Pro Pro 
        435                 440                 445             


Thr Pro Gly Val Pro Asp Leu Val Asp Phe Gln Pro Pro Pro Glu Leu 
    450                 455                 460                 


Val Leu Arg Glu Ala Gly Glu Glu Val Pro Asp Ala Gly Pro Arg Glu 
465                 470                 475                 480 


Gly Val Ser Phe Pro Trp Ser Arg Pro Pro Gly Gln Gly Glu Phe Arg 
                485                 490                 495     


Ala Leu Asn Ala Arg Leu Pro Leu Asn Thr Asp Ala Tyr Leu Ser Leu 
            500                 505                 510         


Gln Glu Leu Gln Gly Gln Asp Pro Thr His Leu Val 
        515                 520                 


<210>  184
<211>  347
<212>  PRT
<213>  Homo sapiens

<400>  184

Leu Asn Thr Thr Ile Leu Thr Pro Asn Gly Asn Glu Asp Thr Thr Ala 
1               5                   10                  15      


Asp Phe Phe Leu Thr Thr Met Pro Thr Asp Ser Leu Ser Val Ser Thr 
            20                  25                  30          


Leu Pro Leu Pro Glu Val Gln Cys Phe Val Phe Asn Val Glu Tyr Met 
        35                  40                  45              


Asn Cys Thr Trp Asn Ser Ser Ser Glu Pro Gln Pro Thr Asn Leu Thr 
    50                  55                  60                  


Leu His Tyr Trp Tyr Lys Asn Ser Asp Asn Asp Lys Val Gln Lys Cys 
65                  70                  75                  80  


Ser His Tyr Leu Phe Ser Glu Glu Ile Thr Ser Gly Cys Gln Leu Gln 
                85                  90                  95      


Lys Lys Glu Ile His Leu Tyr Gln Thr Phe Val Val Gln Leu Gln Asp 
            100                 105                 110         


Pro Arg Glu Pro Arg Arg Gln Ala Thr Gln Met Leu Lys Leu Gln Asn 
        115                 120                 125             


Leu Val Ile Pro Trp Ala Pro Glu Asn Leu Thr Leu His Lys Leu Ser 
    130                 135                 140                 


Glu Ser Gln Leu Glu Leu Asn Trp Asn Asn Arg Phe Leu Asn His Cys 
145                 150                 155                 160 


Leu Glu His Leu Val Gln Tyr Arg Thr Asp Trp Asp His Ser Trp Thr 
                165                 170                 175     


Glu Gln Ser Val Asp Tyr Arg His Lys Phe Ser Leu Pro Ser Val Asp 
            180                 185                 190         


Gly Gln Lys Arg Tyr Thr Phe Arg Val Arg Ser Arg Phe Asn Pro Leu 
        195                 200                 205             


Cys Gly Ser Ala Gln His Trp Ser Glu Trp Ser His Pro Ile His Trp 
    210                 215                 220                 


Gly Ser Asn Thr Ser Lys Glu Asn Pro Phe Leu Phe Ala Leu Glu Ala 
225                 230                 235                 240 


Val Val Ile Ser Val Gly Ser Met Gly Leu Ile Ile Ser Leu Leu Cys 
                245                 250                 255     


Val Tyr Phe Trp Leu Glu Arg Thr Met Pro Arg Ile Pro Thr Leu Lys 
            260                 265                 270         


Asn Leu Glu Asp Leu Val Thr Glu Tyr His Gly Asn Phe Ser Ala Trp 
        275                 280                 285             


Ser Gly Val Ser Lys Gly Leu Ala Glu Ser Leu Gln Pro Asp Tyr Ser 
    290                 295                 300                 


Glu Arg Leu Cys Leu Val Ser Glu Ile Pro Pro Lys Gly Gly Ala Leu 
305                 310                 315                 320 


Gly Glu Gly Pro Gly Ala Ser Pro Cys Asn Gln His Ser Pro Tyr Trp 
                325                 330                 335     


Ala Pro Pro Cys Tyr Thr Leu Lys Pro Glu Thr 
            340                 345         


<210>  185
<211>  245
<212>  PRT
<213>  Homo sapiens

<400>  185

Met Arg Ile Phe Ala Val Phe Ile Phe Met Thr Tyr Trp His Leu Leu 
1               5                   10                  15      


Asn Ala Phe Thr Val Thr Val Pro Lys Asp Leu Tyr Val Val Glu Tyr 
            20                  25                  30          


Gly Ser Asn Met Thr Ile Glu Cys Lys Phe Pro Val Glu Lys Gln Leu 
        35                  40                  45              


Asp Leu Ala Ala Leu Ile Val Tyr Trp Glu Met Glu Asp Lys Asn Ile 
    50                  55                  60                  


Ile Gln Phe Val His Gly Glu Glu Asp Leu Lys Val Gln His Ser Ser 
65                  70                  75                  80  


Tyr Arg Gln Arg Ala Arg Leu Leu Lys Asp Gln Leu Ser Leu Gly Asn 
                85                  90                  95      


Ala Ala Leu Gln Ile Thr Asp Val Lys Leu Gln Asp Ala Gly Val Tyr 
            100                 105                 110         


Arg Cys Met Ile Ser Tyr Gly Gly Ala Asp Tyr Lys Arg Ile Thr Val 
        115                 120                 125             


Lys Val Asn Ala Pro Tyr Asn Lys Ile Asn Gln Arg Ile Leu Val Val 
    130                 135                 140                 


Asp Pro Val Thr Ser Glu His Glu Leu Thr Cys Gln Ala Glu Gly Tyr 
145                 150                 155                 160 


Pro Lys Ala Glu Val Ile Trp Thr Ser Ser Asp His Gln Val Leu Ser 
                165                 170                 175     


Gly Lys Thr Thr Thr Thr Asn Ser Lys Arg Glu Glu Lys Leu Phe Asn 
            180                 185                 190         


Val Thr Ser Thr Leu Arg Ile Asn Thr Thr Thr Asn Glu Ile Phe Tyr 
        195                 200                 205             


Cys Thr Phe Arg Arg Leu Asp Pro Glu Glu Asn His Thr Ala Glu Leu 
    210                 215                 220                 


Val Ile Pro Gly Asn Ile Leu Asn Val Ser Ile Lys Ile Cys Leu Thr 
225                 230                 235                 240 


Leu Ser Pro Ser Thr 
                245 


<210>  186
<211>  219
<212>  PRT
<213>  Homo sapiens

<400>  186

Phe Thr Val Thr Val Pro Lys Asp Leu Tyr Val Val Glu Tyr Gly Ser 
1               5                   10                  15      


Asn Met Thr Ile Glu Cys Lys Phe Pro Val Glu Lys Gln Leu Asp Leu 
            20                  25                  30          


Ala Ala Leu Ile Val Tyr Trp Glu Met Glu Asp Lys Asn Ile Ile Gln 
        35                  40                  45              


Phe Val His Gly Glu Glu Asp Leu Lys Val Gln His Ser Ser Tyr Arg 
    50                  55                  60                  


Gln Arg Ala Arg Leu Leu Lys Asp Gln Leu Ser Leu Gly Asn Ala Ala 
65                  70                  75                  80  


Leu Gln Ile Thr Asp Val Lys Leu Gln Asp Ala Gly Val Tyr Arg Cys 
                85                  90                  95      


Met Ile Ser Tyr Gly Gly Ala Asp Tyr Lys Arg Ile Thr Val Lys Val 
            100                 105                 110         


Asn Ala Pro Tyr Asn Lys Ile Asn Gln Arg Ile Leu Val Val Asp Pro 
        115                 120                 125             


Val Thr Ser Glu His Glu Leu Thr Cys Gln Ala Glu Gly Tyr Pro Lys 
    130                 135                 140                 


Ala Glu Val Ile Trp Thr Ser Ser Asp His Gln Val Leu Ser Gly Lys 
145                 150                 155                 160 


Thr Thr Thr Thr Asn Ser Lys Arg Glu Glu Lys Leu Phe Asn Val Thr 
                165                 170                 175     


Ser Thr Leu Arg Ile Asn Thr Thr Thr Asn Glu Ile Phe Tyr Cys Thr 
            180                 185                 190         


Phe Arg Arg Leu Asp Pro Glu Glu Asn His Thr Ala Glu Leu Val Ile 
        195                 200                 205             


Pro Gly Asn Ile Leu Asn Val Ser Ile Lys Ile 
    210                 215                 


<210>  187
<211>  227
<212>  PRT
<213>  Homo sapiens

<400>  187

Phe Thr Val Thr Val Pro Lys Asp Leu Tyr Val Val Glu Tyr Gly Ser 
1               5                   10                  15      


Asn Met Thr Ile Glu Cys Lys Phe Pro Val Glu Lys Gln Leu Asp Leu 
            20                  25                  30          


Ala Ala Leu Ile Val Tyr Trp Glu Met Glu Asp Lys Asn Ile Ile Gln 
        35                  40                  45              


Phe Val His Gly Glu Glu Asp Leu Lys Val Gln His Ser Ser Tyr Arg 
    50                  55                  60                  


Gln Arg Ala Arg Leu Leu Lys Asp Gln Leu Ser Leu Gly Asn Ala Ala 
65                  70                  75                  80  


Leu Gln Ile Thr Asp Val Lys Leu Gln Asp Ala Gly Val Tyr Arg Cys 
                85                  90                  95      


Met Ile Ser Tyr Gly Gly Ala Asp Tyr Lys Arg Ile Thr Val Lys Val 
            100                 105                 110         


Asn Ala Pro Tyr Asn Lys Ile Asn Gln Arg Ile Leu Val Val Asp Pro 
        115                 120                 125             


Val Thr Ser Glu His Glu Leu Thr Cys Gln Ala Glu Gly Tyr Pro Lys 
    130                 135                 140                 


Ala Glu Val Ile Trp Thr Ser Ser Asp His Gln Val Leu Ser Gly Lys 
145                 150                 155                 160 


Thr Thr Thr Thr Asn Ser Lys Arg Glu Glu Lys Leu Phe Asn Val Thr 
                165                 170                 175     


Ser Thr Leu Arg Ile Asn Thr Thr Thr Asn Glu Ile Phe Tyr Cys Thr 
            180                 185                 190         


Phe Arg Arg Leu Asp Pro Glu Glu Asn His Thr Ala Glu Leu Val Ile 
        195                 200                 205             


Pro Glu Leu Pro Leu Ala His Pro Pro Asn Glu Arg Leu Asn Val Ser 
    210                 215                 220                 


Ile Lys Ile 
225         


<210>  188
<211>  124
<212>  PRT
<213>  Homo sapiens

<400>  188

Ala Phe Thr Val Thr Val Pro Lys Asp Leu Tyr Val Val Glu Tyr Gly 
1               5                   10                  15      


Ser Asn Met Thr Ile Glu Cys Lys Phe Pro Val Glu Lys Gln Leu Asp 
            20                  25                  30          


Leu Ala Ala Leu Ile Val Tyr Trp Glu Met Glu Asp Lys Asn Ile Ile 
        35                  40                  45              


Gln Phe Val His Gly Glu Glu Asp Leu Lys Thr Gln His Ser Ser Tyr 
    50                  55                  60                  


Arg Gln Arg Ala Arg Leu Leu Lys Asp Gln Leu Ser Leu Gly Asn Ala 
65                  70                  75                  80  


Ala Leu Gln Ile Thr Asp Val Lys Leu Gln Asp Ala Gly Val Tyr Arg 
                85                  90                  95      


Cys Met Ile Ser Tyr Gly Gly Ala Asp Tyr Lys Arg Ile Thr Val Lys 
            100                 105                 110         


Val Asn Ala Pro Tyr Ala Ala Ala Leu His Glu His 
        115                 120                 


<210>  189
<211>  268
<212>  PRT
<213>  Homo sapiens

<400>  189

Pro Gly Trp Phe Leu Asp Ser Pro Asp Arg Pro Trp Asn Pro Pro Thr 
1               5                   10                  15      


Phe Ser Pro Ala Leu Leu Val Val Thr Glu Gly Asp Asn Ala Thr Phe 
            20                  25                  30          


Thr Cys Ser Phe Ser Asn Thr Ser Glu Ser Phe Val Leu Asn Trp Tyr 
        35                  40                  45              


Arg Met Ser Pro Ser Asn Gln Thr Asp Lys Leu Ala Ala Phe Pro Glu 
    50                  55                  60                  


Asp Arg Ser Gln Pro Gly Gln Asp Cys Arg Phe Arg Val Thr Gln Leu 
65                  70                  75                  80  


Pro Asn Gly Arg Asp Phe His Met Ser Val Val Arg Ala Arg Arg Asn 
                85                  90                  95      


Asp Ser Gly Thr Tyr Leu Cys Gly Ala Ile Ser Leu Ala Pro Lys Ala 
            100                 105                 110         


Gln Ile Lys Glu Ser Leu Arg Ala Glu Leu Arg Val Thr Glu Arg Arg 
        115                 120                 125             


Ala Glu Val Pro Thr Ala His Pro Ser Pro Ser Pro Arg Pro Ala Gly 
    130                 135                 140                 


Gln Phe Gln Thr Leu Val Val Gly Val Val Gly Gly Leu Leu Gly Ser 
145                 150                 155                 160 


Leu Val Leu Leu Val Trp Val Leu Ala Val Ile Cys Ser Arg Ala Ala 
                165                 170                 175     


Arg Gly Thr Ile Gly Ala Arg Arg Thr Gly Gln Pro Leu Lys Glu Asp 
            180                 185                 190         


Pro Ser Ala Val Pro Val Phe Ser Val Asp Tyr Gly Glu Leu Asp Phe 
        195                 200                 205             


Gln Trp Arg Glu Lys Thr Pro Glu Pro Pro Val Pro Cys Val Pro Glu 
    210                 215                 220                 


Gln Thr Glu Tyr Ala Thr Ile Val Phe Pro Ser Gly Met Gly Thr Ser 
225                 230                 235                 240 


Ser Pro Ala Arg Arg Gly Ser Ala Asp Gly Pro Arg Ser Ala Gln Pro 
                245                 250                 255     


Leu Arg Pro Glu Asp Gly His Cys Ser Trp Pro Leu 
            260                 265             


<210>  190
<211>  254
<212>  PRT
<213>  Homo sapiens

<400>  190

Met Glu Tyr Ala Ser Asp Ala Ser Leu Asp Pro Glu Ala Pro Trp Pro 
1               5                   10                  15      


Pro Ala Pro Arg Ala Arg Ala Cys Arg Val Leu Pro Trp Ala Leu Val 
            20                  25                  30          


Ala Gly Leu Leu Leu Leu Leu Leu Leu Ala Ala Ala Cys Ala Val Phe 
        35                  40                  45              


Leu Ala Cys Pro Trp Ala Val Ser Gly Ala Arg Ala Ser Pro Gly Ser 
    50                  55                  60                  


Ala Ala Ser Pro Arg Leu Arg Glu Gly Pro Glu Leu Ser Pro Asp Asp 
65                  70                  75                  80  


Pro Ala Gly Leu Leu Asp Leu Arg Gln Gly Met Phe Ala Gln Leu Val 
                85                  90                  95      


Ala Gln Asn Val Leu Leu Ile Asp Gly Pro Leu Ser Trp Tyr Ser Asp 
            100                 105                 110         


Pro Gly Leu Ala Gly Val Ser Leu Thr Gly Gly Leu Ser Tyr Lys Glu 
        115                 120                 125             


Asp Thr Lys Glu Leu Val Val Ala Lys Ala Gly Val Tyr Tyr Val Phe 
    130                 135                 140                 


Phe Gln Leu Glu Leu Arg Arg Val Val Ala Gly Glu Gly Ser Gly Ser 
145                 150                 155                 160 


Val Ser Leu Ala Leu His Leu Gln Pro Leu Arg Ser Ala Ala Gly Ala 
                165                 170                 175     


Ala Ala Leu Ala Leu Thr Val Asp Leu Pro Pro Ala Ser Ser Glu Ala 
            180                 185                 190         


Arg Asn Ser Ala Phe Gly Phe Gln Gly Arg Leu Leu His Leu Ser Ala 
        195                 200                 205             


Gly Gln Arg Leu Gly Val His Leu His Thr Glu Ala Arg Ala Arg His 
    210                 215                 220                 


Ala Trp Gln Leu Thr Gln Gly Ala Thr Val Leu Gly Leu Phe Arg Val 
225                 230                 235                 240 


Thr Pro Glu Ile Pro Ala Gly Leu Pro Ser Pro Arg Ser Glu 
                245                 250                 


<210>  191
<211>  174
<212>  PRT
<213>  Homo sapiens

<400>  191

Pro Ala Gly Leu Leu Asp Leu Arg Gln Gly Met Phe Ala Gln Leu Val 
1               5                   10                  15      


Ala Gln Asn Val Leu Leu Ile Asp Gly Pro Leu Ser Trp Tyr Ser Asp 
            20                  25                  30          


Pro Gly Leu Ala Gly Val Ser Leu Thr Gly Gly Leu Ser Tyr Lys Glu 
        35                  40                  45              


Asp Thr Lys Glu Leu Val Val Ala Lys Ala Gly Val Tyr Tyr Val Phe 
    50                  55                  60                  


Phe Gln Leu Glu Leu Arg Arg Val Val Ala Gly Glu Gly Ser Gly Ser 
65                  70                  75                  80  


Val Ser Leu Ala Leu His Leu Gln Pro Leu Arg Ser Ala Ala Gly Ala 
                85                  90                  95      


Ala Ala Leu Ala Leu Thr Val Asp Leu Pro Pro Ala Ser Ser Glu Ala 
            100                 105                 110         


Arg Asn Ser Ala Phe Gly Phe Gln Gly Arg Leu Leu His Leu Ser Ala 
        115                 120                 125             


Gly Gln Arg Leu Gly Val His Leu His Thr Glu Ala Arg Ala Arg His 
    130                 135                 140                 


Ala Trp Gln Leu Thr Gln Gly Ala Thr Val Leu Gly Leu Phe Arg Val 
145                 150                 155                 160 


Thr Pro Glu Ile Pro Ala Gly Leu Pro Ser Pro Arg Ser Glu 
                165                 170                 


<210>  192
<211>  175
<212>  PRT
<213>  Homo sapiens

<400>  192

Asp Pro Ala Gly Leu Leu Asp Leu Arg Gln Gly Met Phe Ala Gln Leu 
1               5                   10                  15      


Val Ala Gln Asn Val Leu Leu Ile Asp Gly Pro Leu Ser Trp Tyr Ser 
            20                  25                  30          


Asp Pro Gly Leu Ala Gly Val Ser Leu Thr Gly Gly Leu Ser Tyr Lys 
        35                  40                  45              


Glu Asp Thr Lys Glu Leu Val Val Ala Lys Ala Gly Val Tyr Tyr Val 
    50                  55                  60                  


Phe Phe Gln Leu Glu Leu Arg Arg Val Val Ala Gly Glu Gly Ser Gly 
65                  70                  75                  80  


Ser Val Ser Leu Ala Leu His Leu Gln Pro Leu Arg Ser Ala Ala Gly 
                85                  90                  95      


Ala Ala Ala Leu Ala Leu Thr Val Asp Leu Pro Pro Ala Ser Ser Glu 
            100                 105                 110         


Ala Arg Asn Ser Ala Phe Gly Phe Gln Gly Arg Leu Leu His Leu Ser 
        115                 120                 125             


Ala Gly Gln Arg Leu Gly Val His Leu His Thr Glu Ala Arg Ala Arg 
    130                 135                 140                 


His Ala Trp Gln Leu Thr Gln Gly Ala Thr Val Leu Gly Leu Phe Arg 
145                 150                 155                 160 


Val Thr Pro Glu Ile Pro Ala Gly Leu Pro Ser Pro Arg Ser Glu 
                165                 170                 175 


<210>  193
<211>  167
<212>  PRT
<213>  Homo sapiens

<400>  193

Asp Pro Ala Gly Leu Leu Asp Leu Arg Gln Gly Met Phe Ala Gln Leu 
1               5                   10                  15      


Val Ala Gln Asn Val Leu Leu Ile Asp Gly Pro Leu Ser Trp Tyr Ser 
            20                  25                  30          


Asp Pro Gly Leu Ala Gly Val Ser Leu Thr Gly Gly Leu Ser Tyr Lys 
        35                  40                  45              


Glu Asp Thr Lys Glu Leu Val Val Ala Lys Ala Gly Val Tyr Tyr Val 
    50                  55                  60                  


Phe Phe Gln Leu Glu Leu Arg Arg Val Val Ala Gly Glu Gly Ser Gly 
65                  70                  75                  80  


Ser Val Ser Leu Ala Leu His Leu Gln Pro Leu Arg Ser Ala Ala Gly 
                85                  90                  95      


Ala Ala Ala Leu Ala Leu Thr Val Asp Leu Pro Pro Ala Ser Ser Glu 
            100                 105                 110         


Ala Arg Asn Ser Ala Phe Gly Phe Gln Gly Arg Leu Leu His Leu Ser 
        115                 120                 125             


Ala Gly Gln Arg Leu Gly Val His Leu His Thr Glu Ala Arg Ala Arg 
    130                 135                 140                 


His Ala Trp Gln Leu Thr Gln Gly Ala Thr Val Leu Gly Leu Phe Arg 
145                 150                 155                 160 


Val Thr Pro Glu Ile Pro Ala 
                165         


<210>  194
<211>  255
<212>  PRT
<213>  Homo sapiens

<400>  194

Met Gly Asn Ser Cys Tyr Asn Ile Val Ala Thr Leu Leu Leu Val Leu 
1               5                   10                  15      


Asn Phe Glu Arg Thr Arg Ser Leu Gln Asp Pro Cys Ser Asn Cys Pro 
            20                  25                  30          


Ala Gly Thr Phe Cys Asp Asn Asn Arg Asn Gln Ile Cys Ser Pro Cys 
        35                  40                  45              


Pro Pro Asn Ser Phe Ser Ser Ala Gly Gly Gln Arg Thr Cys Asp Ile 
    50                  55                  60                  


Cys Arg Gln Cys Lys Gly Val Phe Arg Thr Arg Lys Glu Cys Ser Ser 
65                  70                  75                  80  


Thr Ser Asn Ala Glu Cys Asp Cys Thr Pro Gly Phe His Cys Leu Gly 
                85                  90                  95      


Ala Gly Cys Ser Met Cys Glu Gln Asp Cys Lys Gln Gly Gln Glu Leu 
            100                 105                 110         


Thr Lys Lys Gly Cys Lys Asp Cys Cys Phe Gly Thr Phe Asn Asp Gln 
        115                 120                 125             


Lys Arg Gly Ile Cys Arg Pro Trp Thr Asn Cys Ser Leu Asp Gly Lys 
    130                 135                 140                 


Ser Val Leu Val Asn Gly Thr Lys Glu Arg Asp Val Val Cys Gly Pro 
145                 150                 155                 160 


Ser Pro Ala Asp Leu Ser Pro Gly Ala Ser Ser Val Thr Pro Pro Ala 
                165                 170                 175     


Pro Ala Arg Glu Pro Gly His Ser Pro Gln Ile Ile Ser Phe Phe Leu 
            180                 185                 190         


Ala Leu Thr Ser Thr Ala Leu Leu Phe Leu Leu Phe Phe Leu Thr Leu 
        195                 200                 205             


Arg Phe Ser Val Val Lys Arg Gly Arg Lys Lys Leu Leu Tyr Ile Phe 
    210                 215                 220                 


Lys Gln Pro Phe Met Arg Pro Val Gln Thr Thr Gln Glu Glu Asp Gly 
225                 230                 235                 240 


Cys Ser Cys Arg Phe Pro Glu Glu Glu Glu Gly Gly Cys Glu Leu 
                245                 250                 255 


<210>  195
<211>  5
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Peptide suitable for use as a linker.

<400>  195

Gly Ser Gly Gly Ser 
1               5   


<210>  196
<211>  4
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Peptide suitable for use as a linker.

<400>  196

Gly Gly Gly Ser 
1               


<210>  197
<211>  4
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Peptide suitable for use as a linker.

<400>  197

Gly Gly Ser Gly 
1               


<210>  198
<211>  5
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Peptide suitable for use as a linker.

<400>  198

Gly Gly Ser Gly Gly 
1               5   


<210>  199
<211>  5
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Peptide suitable for use as a linker.

<400>  199

Gly Ser Gly Ser Gly 
1               5   


<210>  200
<211>  5
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Peptide suitable for use as a linker.

<400>  200

Gly Ser Gly Gly Gly 
1               5   


<210>  201
<211>  5
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Peptide suitable for use as a linker.

<400>  201

Gly Gly Gly Ser Gly 
1               5   


<210>  202
<211>  5
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Peptide suitable for use as a linker.

<400>  202

Gly Ser Ser Ser Gly 
1               5   


<210>  203
<211>  5
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Peptide suitable for use as a linker.

<400>  203

Gly Ser Ser Ser Ser 
1               5   


<210>  204
<211>  5
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Peptide suitable for use as a linker.

<400>  204

Ala Ala Ala Gly Gly 
1               5   


<210>  205
<211>  5
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Peptide suitable for use as a linker. The EAAAK may be repeated 2
       to 20 times.

<400>  205

Glu Ala Ala Ala Lys 
1               5   


<210>  206
<211>  7
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Peptide suitable for use as a linker. The EAAAK subset may be 
       repeated 2 to 20 times.

<400>  206

Ala Glu Ala Ala Ala Lys Ala 
1               5           


<210>  207
<211>  16
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Peptide suitable for use as a linker. The EAAAK subset may be 
       repeated independently 2 to 20 times.

<400>  207

Ala Glu Ala Ala Ala Lys Ala Leu Glu Ala Glu Ala Ala Ala Lys Ala 
1               5                   10                  15      


<210>  208
<211>  5
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Peptide suitable for use as a linker

<400>  208

Glu Ala Ala Ala Lys 
1               5   


<210>  209
<211>  10
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Peptide suitable for use as a linker.

<400>  209

Glu Ala Ala Ala Lys Glu Ala Ala Ala Lys 
1               5                   10  


<210>  210
<211>  15
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Peptide suitable for use as a linker.

<400>  210

Glu Ala Ala Ala Lys Glu Ala Ala Ala Lys Glu Ala Ala Ala Lys 
1               5                   10                  15  


<210>  211
<211>  46
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Peptide suitable for use as a linker.

<400>  211

Ala Glu Ala Ala Ala Lys Glu Ala Ala Ala Lys Glu Ala Ala Ala Lys 
1               5                   10                  15      


Glu Ala Ala Ala Lys Ala Leu Glu Ala Glu Ala Ala Ala Lys Glu Ala 
            20                  25                  30          


Ala Ala Lys Glu Ala Ala Ala Lys Glu Ala Ala Ala Lys Ala 
        35                  40                  45      


<210>  212
<211>  12
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Peptide suitable for use as a linker.

<400>  212

Ala Glu Ala Ala Ala Lys Glu Ala Ala Ala Lys Ala 
1               5                   10          


<210>  213
<211>  5
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Peptide suitable for use as a linker.

<400>  213

Pro Ala Pro Ala Pro 
1               5   


<210>  214
<211>  8
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Peptide suitable for use as a linker.

<400>  214

Ala Pro Ala Pro Ala Pro Ala Pro 
1               5               


<210>  215
<211>  12
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Peptide suitable for use as a linker.

<400>  215

Ala Pro Ala Pro Ala Pro Ala Pro Ala Pro Ala Pro 
1               5                   10          


<210>  216
<211>  16
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Peptide suitable for use as a linker.

<400>  216

Ala Pro Ala Pro Ala Pro Ala Pro Ala Pro Ala Pro Ala Pro Ala Pro 
1               5                   10                  15      


<210>  217
<211>  20
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Peptide suitable for use as a linker.

<400>  217

Ala Pro Ala Pro Ala Pro Ala Pro Ala Pro Ala Pro Ala Pro Ala Pro 
1               5                   10                  15      


Ala Pro Ala Pro 
            20  


<210>  218
<211>  4
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Peptide suitable for use as a linker.

<400>  218

Lys Pro Lys Pro 
1               


<210>  219
<211>  8
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Peptide suitable for use as a linker.

<400>  219

Lys Pro Lys Pro Lys Pro Lys Pro 
1               5               


<210>  220
<211>  12
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Peptide suitable for use as a linker.

<400>  220

Lys Pro Lys Pro Lys Pro Lys Pro Lys Pro Lys Pro 
1               5                   10          


<210>  221
<211>  16
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Peptide suitable for use as a linker.

<400>  221

Lys Pro Lys Pro Lys Pro Lys Pro Lys Pro Lys Pro Lys Pro Lys Pro 
1               5                   10                  15      


<210>  222
<211>  20
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Peptide suitable for use as a linker.

<400>  222

Lys Pro Lys Pro Lys Pro Lys Pro Lys Pro Lys Pro Lys Pro Lys Pro 
1               5                   10                  15      


Lys Pro Lys Pro 
            20  


<210>  223
<211>  4
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Peptide suitable for use as a linker.

<400>  223

Glu Pro Glu Pro 
1               


<210>  224
<211>  8
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Peptide suitable for use as a linker.

<400>  224

Glu Pro Glu Pro Glu Pro Glu Pro 
1               5               


<210>  225
<211>  12
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Peptide suitable for use as a linker.

<400>  225

Glu Pro Glu Pro Glu Pro Glu Pro Glu Pro Glu Pro 
1               5                   10          


<210>  226
<211>  16
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Peptide suitable for use as a linker.

<400>  226

Glu Pro Glu Pro Glu Pro Glu Pro Glu Pro Glu Pro Glu Pro Glu Pro 
1               5                   10                  15      


<210>  227
<211>  20
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Peptide suitable for use as a linker.

<400>  227

Glu Pro Glu Pro Glu Pro Glu Pro Glu Pro Glu Pro Glu Pro Glu Pro 
1               5                   10                  15      


Glu Pro Glu Pro 
            20  


<210>  228
<211>  15
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Linker

<400>  228

Gly Cys Gly Ala Ser Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser 
1               5                   10                  15  


<210>  229
<211>  15
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Peptide suitable for use as a linker.

<400>  229

Gly Cys Gly Gly Ser Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser 
1               5                   10                  15  


<210>  230
<211>  15
<212>  PRT
<213>  Homo sapiens

<400>  230

Glu Asn Pro Val Val His Phe Phe Lys Asn Ile Val Thr Pro Arg 
1               5                   10                  15  


<210>  231
<211>  15
<212>  PRT
<213>  Homo sapiens

<400>  231

Gly Lys Thr Lys Glu Gly Val Leu Tyr Val Gly Ser Lys Thr Lys 
1               5                   10                  15  


<210>  232
<211>  15
<212>  PRT
<213>  Homo sapiens

<400>  232

Lys Thr Lys Glu Gly Val Leu Tyr Val Gly Ser Lys Thr Lys Glu 
1               5                   10                  15  


<210>  233
<211>  15
<212>  PRT
<213>  Homo sapiens

<400>  233

Met Pro Val Asp Pro Asp Asn Glu Ala Tyr Glu Met Pro Ser Glu 
1               5                   10                  15  


<210>  234
<211>  15
<212>  PRT
<213>  Homo sapiens

<400>  234

Asp Asn Glu Ala Tyr Glu Met Pro Ser Glu Glu Gly Tyr Gln Asp 
1               5                   10                  15  


<210>  235
<211>  14
<212>  PRT
<213>  Homo sapiens

<400>  235

Glu Met Pro Ser Glu Glu Gly Tyr Gln Asp Tyr Glu Pro Glu 
1               5                   10                  


<210>  236
<211>  12
<212>  PRT
<213>  Homo sapiens

<400>  236

Ser Glu Glu Gly Tyr Gln Asp Tyr Glu Pro Glu Ala 
1               5                   10          


<210>  237
<211>  8
<212>  PRT
<213>  Arachis hypogaea

<400>  237

Pro Gly Gln Phe Glu Asp Phe Phe 
1               5               


<210>  238
<211>  8
<212>  PRT
<213>  Arachis hypogaea

<400>  238

Tyr Leu Gln Gly Phe Ser Arg Asn 
1               5               


<210>  239
<211>  10
<212>  PRT
<213>  Arachis hypogaea

<400>  239

Phe Asn Ala Glu Phe Asn Glu Ile Arg Arg 
1               5                   10  


<210>  240
<211>  8
<212>  PRT
<213>  Arachis hypogaea

<400>  240

Gln Glu Glu Arg Gly Gln Arg Arg 
1               5               


<210>  241
<211>  10
<212>  PRT
<213>  Arachis hypogaea

<400>  241

Asp Ile Thr Asn Pro Ile Asn Leu Arg Glu 
1               5                   10  


<210>  242
<211>  10
<212>  PRT
<213>  Arachis hypogaea

<400>  242

Asn Asn Phe Gly Lys Leu Phe Glu Val Lys 
1               5                   10  


<210>  243
<211>  6
<212>  PRT
<213>  Arachis hypogaea

<400>  243

Gly Asn Leu Glu Leu Val 
1               5       


<210>  244
<211>  10
<212>  PRT
<213>  Arachis hypogaea

<400>  244

Arg Arg Tyr Thr Ala Arg Leu Lys Glu Gly 
1               5                   10  


<210>  245
<211>  10
<212>  PRT
<213>  Arachis hypogaea

<400>  245

Glu Leu His Leu Leu Gly Phe Gly Ile Asn 
1               5                   10  


<210>  246
<211>  10
<212>  PRT
<213>  Arachis hypogaea

<400>  246

His Arg Ile Phe Leu Ala Gly Asp Lys Asp 
1               5                   10  


<210>  247
<211>  10
<212>  PRT
<213>  Arachis hypogaea

<400>  247

Ile Asp Gln Ile Glu Lys Gln Ala Lys Asp 
1               5                   10  


<210>  248
<211>  10
<212>  PRT
<213>  Arachis hypogaea

<400>  248

Lys Asp Leu Ala Phe Pro Gly Ser Gly Glu 
1               5                   10  


<210>  249
<211>  10
<212>  PRT
<213>  Arachis hypogaea

<400>  249

Lys Glu Ser His Phe Val Ser Ala Arg Pro 
1               5                   10  


<210>  250
<211>  25
<212>  PRT
<213>  Arachis hypogaea

<400>  250

Asn Glu Gly Val Ile Val Lys Val Ser Lys Glu His Val Glu Glu Leu 
1               5                   10                  15      


Thr Lys His Ala Lys Ser Val Ser Lys 
            20                  25  


<210>  251
<211>  10
<212>  PRT
<213>  Arachis hypogaea

<400>  251

His Ala Ser Ala Arg Gln Gln Trp Glu Leu 
1               5                   10  


<210>  252
<211>  10
<212>  PRT
<213>  Arachis hypogaea

<400>  252

Gln Trp Glu Leu Gln Gly Asp Arg Arg Cys 
1               5                   10  


<210>  253
<211>  10
<212>  PRT
<213>  Arachis hypogaea

<400>  253

Asp Arg Arg Cys Gln Ser Gln Leu Glu Arg 
1               5                   10  


<210>  254
<211>  10
<212>  PRT
<213>  Arachis hypogaea

<400>  254

Leu Arg Pro Cys Glu Gln His Leu Met Gln 
1               5                   10  


<210>  255
<211>  10
<212>  PRT
<213>  Arachis hypogaea

<400>  255

Lys Ile Gln Arg Asp Glu Asp Ser Tyr Glu 
1               5                   10  


<210>  256
<211>  10
<212>  PRT
<213>  Arachis hypogaea

<400>  256

Tyr Glu Arg Asp Pro Tyr Ser Pro Ser Gln 
1               5                   10  


<210>  257
<211>  10
<212>  PRT
<213>  Arachis hypogaea

<400>  257

Ser Gln Asp Pro Tyr Ser Pro Ser Pro Tyr 
1               5                   10  


<210>  258
<211>  10
<212>  PRT
<213>  Arachis hypogaea

<400>  258

Asp Arg Leu Gln Gly Arg Gln Gln Glu Gln 
1               5                   10  


<210>  259
<211>  10
<212>  PRT
<213>  Arachis hypogaea

<400>  259

Lys Arg Glu Leu Arg Asn Leu Pro Gln Gln 
1               5                   10  


<210>  260
<211>  10
<212>  PRT
<213>  Arachis hypogaea

<400>  260

Gln Arg Cys Asp Leu Asp Val Glu Ser Gly 
1               5                   10  


<210>  261
<211>  15
<212>  PRT
<213>  Arachis hypogaea

<400>  261

Ile Glu Thr Trp Asn Pro Asn Asn Gln Glu Phe Glu Cys Ala Gly 
1               5                   10                  15  


<210>  262
<211>  15
<212>  PRT
<213>  Arachis hypogaea

<400>  262

Gly Asn Ile Phe Ser Gly Phe Thr Pro Glu Phe Leu Ala Gln Ala 
1               5                   10                  15  


<210>  263
<211>  15
<212>  PRT
<213>  Arachis hypogaea

<400>  263

Val Thr Val Arg Gly Gly Leu Arg Ile Leu Ser Pro Asp Arg Lys 
1               5                   10                  15  


<210>  264
<211>  15
<212>  PRT
<213>  Arachis hypogaea

<400>  264

Asp Glu Asp Glu Tyr Glu Tyr Asp Glu Glu Asp Arg Arg Arg Gly 
1               5                   10                  15  


<210>  265
<211>  9
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Epitope tag hemagglutinin

<400>  265

Tyr Pro Tyr Asp Val Pro Asp Tyr Ala 
1               5                   


<210>  266
<211>  8
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Epitope tag FLAG

<400>  266

Asp Tyr Lys Asp Asp Asp Asp Lys 
1               5               


<210>  267
<211>  10
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Epitope tag  c-myc

<400>  267

Glu Gln Lys Leu Ile Ser Glu Glu Asp Leu 
1               5                   10  


<210>  268
<211>  5
<212>  PRT
<213>  Homo sapiens

<400>  268

His His His His His 
1               5   


<210>  269
<211>  6
<212>  PRT
<213>  Homo sapiens

<400>  269

His His His His His His 
1               5       


<210>  270
<211>  4
<212>  PRT
<213>  Homo sapiens

<400>  270

Phe His His Thr 
1               


<210>  271
<211>  17
<212>  PRT
<213>  Homo sapiens

<400>  271

Trp Glu Ala Ala Ala Arg Glu Ala Cys Cys Arg Glu Cys Cys Ala Arg 
1               5                   10                  15      


Ala 
    


<210>  272
<211>  5
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Affinity Tag

<400>  272

Arg Tyr Ile Arg Ser 
1               5   


<210>  273
<211>  6
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  sulfatase motif


<220>
<221>  VARIANT
<222>  (1)..(1)
<223>  Position 1 (X1) is present or absent and, when present, can be 
       any amino acid, usually L, M, V, S or T, more usually L, M, S or 
       V, with the proviso that, when the sulfatase motif is at the 
       N-terminus of the target polypeptide, X1 is present.

<220>
<221>  VARIANT
<222>  (2)..(2)
<223>  Position 2 (Z1) is cysteine or serine

<220>
<221>  VARIANT
<222>  (3)..(3)
<223>  Position 3 (X2) can be any amino acid, though usually an 
       aliphatic aa, a polar, uncharged aa, or a sulfur containing amino
       acid (e.g., other than an aromatic amino acid or a charged amino 
       acid), usually S, T, A, V, G or C, more usually S, T, A, V or G.

<220>
<221>  VARIANT
<222>  (4)..(4)
<223>  Position 4 (Z2) is either a proline or alanine residue (which can
       also be represented by "P/A")

<220>
<221>  VARIANT
<222>  (5)..(5)
<223>  Position 5 (X3) can be any amino acid, though usually an 
       aliphatic aa, a polar, uncharged aa, or a sulfur containing amino
       acid (e.g., other than an aromatic amino acid or a charged amino 
       acid), usually S, T, A, V, G or C, more usually S, T, A, V or G.

<220>
<221>  VARIANT
<222>  (6)..(6)
<223>  Position (Z3) is a basic amino acid (arginine, lysine, or 
       histidine, usually lysine), or an aliphatic aa (alanine, glycine,
       leucine, valine, isoleucine, or proline, usually A, G, L, V, or 
       I).

<400>  273

Xaa Xaa Xaa Xaa Xaa Xaa 
1               5       


<210>  274
<211>  6
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  sulfatase motif


<220>
<221>  VARIANT
<222>  (1)..(1)
<223>  Position 1 (X1) is present or absent and, when present, can be 
       any aa, usually L, M, V, S or T, more usually L, M, S or V, with 
       the proviso that, when the sulfatase motif is at the N-terminus 
       of the target polypeptide, X1 is present.

<220>
<221>  VARIANT
<222>  (3)..(3)
<223>  Position (X2) can be any amino acid, though usually an aliphatic 
       aa, a polar, uncharged aa, or a sulfur containing amino acid 
       (e.g., other than an aromatic amino acid or a charged amino 
       acid), usually S, T, A, V, G or C, more usually S, T, A, V or G.

<220>
<221>  VARIANT
<222>  (5)..(5)
<223>  Position 5 (X3) can be any amino acid, though usually an 
       aliphatic aa, a polar, uncharged aa, or a sulfur containing amino
       acid (e.g., other than an aromatic amino acid or a charged amino 
       acid), usually S, T, A, V, G or C, more usually S, T, A, V or G.

<220>
<221>  VARIANT
<222>  (6)..(6)
<223>  Position 6 (Z3) is a basic amino acid (arginine, lysine, or 
       histidine, usually lysine), or an aliphatic aa (alanine, glycine,
       leucine, valine, isoleucine, or proline, usually A, G, L, V, or 
       I).

<400>  274

Xaa Cys Xaa Pro Xaa Xaa 
1               5       


<210>  275
<211>  5
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Sulfatase motif


<220>
<221>  VARIANT
<222>  (2)..(2)
<223>  Position 2 (X1) is present or absent and, when present, can be 
       any aa, usually L, M, V, S or T, more usually L, M, S or V, with 
       the proviso that, when the sulfatase motif is at the N-terminus 
       of the target polypeptide, X1 is present.

<220>
<221>  VARIANT
<222>  (4)..(4)
<223>  Position 4 (X2) can be any amino acid, though usually an 
       aliphatic aa, a polar, uncharged aa, or a sulfur containing amino
       acid (e.g., other than an aromatic amino acid or a charged amino 
       acid), usually S, T, A, V, G or C, more usually S, T, A, V or G.

<220>
<221>  VARIANT
<222>  (5)..(5)
<223>  Position 5 (Z3) is a basic amino acid (arginine, lysine, or 
       histidine, usually lysine), or an aliphatic aa (alanine, glycine,
       leucine, valine, isoleucine, or proline, usually A, G, L, V, or 
       I).

<400>  275

Cys Xaa Pro Xaa Xaa 
1               5   


<210>  276
<211>  5
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Transglutaminase Enzyme Site

<400>  276

Leu Leu Gln Gly Gly 
1               5   


<210>  277
<211>  4
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Transglutaminase Enzyme Site

<400>  277

Leu Leu Gln Gly 
1               


<210>  278
<211>  6
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Transglutaminase Enzyme Site

<400>  278

Leu Ser Leu Ser Gln Gly 
1               5       


<210>  279
<211>  6
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Transglutaminase Enzyme Site

<400>  279

Leu Leu Gln Leu Gln Gly 
1               5       


<210>  280
<211>  5
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Sortase A Enzyme Site


<220>
<221>  SITE
<222>  (3)..(3)
<223>  X5 can be any single amino acid.

<220>
<221>  SITE
<222>  (5)..(5)
<223>  X can be a glycine or alanine.

<400>  280

Leu Pro Xaa Thr Xaa 
1               5   


<210>  281
<211>  5
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Sortase enzyme conjugation partner sequence

<400>  281

Gly Gly Gly Gly Gly 
1               5   


<210>  282
<211>  4
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Sortase enzyme conjugation partner sequence

<400>  282

Gly Gly Gly Gly 
1               


<210>  283
<211>  5
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Sortase enzyme conjugation partner sequence

<400>  283

Ala Ala Ala Ala Ala 
1               5   


<210>  284
<211>  4
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Sortase enzyme conjugation partner sequence

<400>  284

Ala Ala Ala Ala 
1               


<210>  285
<211>  6
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Sortase A Enzyme Site

<400>  285

Leu Pro Glu Thr Gly Gly 
1               5       


<210>  286
<211>  6
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Sortase A Enzyme Site

<400>  286

Leu Pro Glu Thr Ala Ala 
1               5       


<210>  287
<211>  8
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Peptide suitable for use as a proteolytically cleavable linker.

<400>  287

Leu Glu Val Leu Phe Gln Gly Pro 
1               5               


<210>  288
<211>  7
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Peptide suitable for use as a proteolytically cleavable linker.

<400>  288

Glu Asn Leu Tyr Thr Gln Ser 
1               5           


<210>  289
<211>  5
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Peptide suitable for use as a proteolytically cleavable linker.

<400>  289

Asp Asp Asp Asp Lys 
1               5   


<210>  290
<211>  4
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Peptide suitable for use as a proteolytically cleavable linker.

<400>  290

Leu Val Pro Arg 
1               


<210>  291
<211>  22
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Peptide suitable for use as a proteolytically cleavable linker.

<400>  291

Gly Ser Gly Ala Thr Asn Phe Ser Leu Leu Lys Gln Ala Gly Asp Val 
1               5                   10                  15      


Glu Glu Asn Pro Gly Pro 
            20          


<210>  292
<211>  5
<212>  PRT
<213>  Homo sapiens

<400>  292

Gln Arg Arg Ala Ala 
1               5   


<210>  293
<211>  5
<212>  PRT
<213>  Homo sapiens

<400>  293

Gln Lys Arg Ala Ala 
1               5   


<210>  294
<211>  5
<212>  PRT
<213>  Homo sapiens

<400>  294

Gln Gln Arg Ala Ala 
1               5   


<210>  295
<211>  5
<212>  PRT
<213>  Homo sapiens

<400>  295

Lys Lys Arg Ala Ala 
1               5   


<210>  296
<211>  5
<212>  PRT
<213>  Homo sapiens

<400>  296

Arg Arg Arg Ala Ala 
1               5   


<210>  297
<211>  5
<212>  PRT
<213>  Homo sapiens

<400>  297

Arg Lys Arg Ala Ala 
1               5   


<210>  298
<211>  390
<212>  PRT
<213>  Homo sapiens

<400>  298

Met Pro Pro Ser Gly Leu Arg Leu Leu Pro Leu Leu Leu Pro Leu Leu 
1               5                   10                  15      


Trp Leu Leu Val Leu Thr Pro Gly Arg Pro Ala Ala Gly Leu Ser Thr 
            20                  25                  30          


Cys Lys Thr Ile Asp Met Glu Leu Val Lys Arg Lys Arg Ile Glu Ala 
        35                  40                  45              


Ile Arg Gly Gln Ile Leu Ser Lys Leu Arg Leu Ala Ser Pro Pro Ser 
    50                  55                  60                  


Gln Gly Glu Val Pro Pro Gly Pro Leu Pro Glu Ala Val Leu Ala Leu 
65                  70                  75                  80  


Tyr Asn Ser Thr Arg Asp Arg Val Ala Gly Glu Ser Ala Glu Pro Glu 
                85                  90                  95      


Pro Glu Pro Glu Ala Asp Tyr Tyr Ala Lys Glu Val Thr Arg Val Leu 
            100                 105                 110         


Met Val Glu Thr His Asn Glu Ile Tyr Asp Lys Phe Lys Gln Ser Thr 
        115                 120                 125             


His Ser Ile Tyr Met Phe Phe Asn Thr Ser Glu Leu Arg Glu Ala Val 
    130                 135                 140                 


Pro Glu Pro Val Leu Leu Ser Arg Ala Glu Leu Arg Leu Leu Arg Leu 
145                 150                 155                 160 


Lys Leu Lys Val Glu Gln His Val Glu Leu Tyr Gln Lys Tyr Ser Asn 
                165                 170                 175     


Asn Ser Trp Arg Tyr Leu Ser Asn Arg Leu Leu Ala Pro Ser Asp Ser 
            180                 185                 190         


Pro Glu Trp Leu Ser Phe Asp Val Thr Gly Val Val Arg Gln Trp Leu 
        195                 200                 205             


Ser Arg Gly Gly Glu Ile Glu Gly Phe Arg Leu Ser Ala His Cys Ser 
    210                 215                 220                 


Cys Asp Ser Arg Asp Asn Thr Leu Gln Val Asp Ile Asn Gly Phe Thr 
225                 230                 235                 240 


Thr Gly Arg Arg Gly Asp Leu Ala Thr Ile His Gly Met Asn Arg Pro 
                245                 250                 255     


Phe Leu Leu Leu Met Ala Thr Pro Leu Glu Arg Ala Gln His Leu Gln 
            260                 265                 270         


Ser Ser Arg His Arg Arg Ala Leu Asp Thr Asn Tyr Cys Phe Ser Ser 
        275                 280                 285             


Thr Glu Lys Asn Cys Cys Val Arg Gln Leu Tyr Ile Asp Phe Arg Lys 
    290                 295                 300                 


Asp Leu Gly Trp Lys Trp Ile His Glu Pro Lys Gly Tyr His Ala Asn 
305                 310                 315                 320 


Phe Cys Leu Gly Pro Cys Pro Tyr Ile Trp Ser Leu Asp Thr Gln Tyr 
                325                 330                 335     


Ser Lys Val Leu Ala Leu Tyr Asn Gln His Asn Pro Gly Ala Ser Ala 
            340                 345                 350         


Ala Pro Cys Cys Val Pro Gln Ala Leu Glu Pro Leu Pro Ile Val Tyr 
        355                 360                 365             


Tyr Val Gly Arg Lys Pro Lys Val Glu Gln Leu Ser Asn Met Ile Val 
    370                 375                 380                 


Arg Ser Cys Lys Cys Ser 
385                 390 


<210>  299
<211>  413
<212>  PRT
<213>  Homo sapiens

<400>  299

Met His Tyr Cys Val Leu Ser Ala Phe Leu Ile Leu His Leu Val Thr 
1               5                   10                  15      


Val Ala Leu Ser Leu Ser Thr Cys Ser Thr Leu Asp Met Asp Gln Phe 
            20                  25                  30          


Met Arg Lys Arg Ile Glu Ala Ile Arg Gly Gln Ile Leu Ser Lys Leu 
        35                  40                  45              


Lys Leu Thr Ser Pro Pro Glu Asp Tyr Pro Glu Pro Glu Glu Val Pro 
    50                  55                  60                  


Pro Glu Val Ile Ser Ile Tyr Asn Ser Thr Arg Asp Leu Leu Gln Glu 
65                  70                  75                  80  


Lys Ala Ser Arg Arg Ala Ala Ala Cys Glu Arg Glu Arg Ser Asp Glu 
                85                  90                  95      


Glu Tyr Tyr Ala Lys Glu Val Tyr Lys Ile Asp Met Pro Pro Phe Phe 
            100                 105                 110         


Pro Ser Glu Ala Ile Pro Pro Thr Phe Tyr Arg Pro Tyr Phe Arg Ile 
        115                 120                 125             


Val Arg Phe Asp Val Ser Ala Met Glu Lys Asn Ala Ser Asn Leu Val 
    130                 135                 140                 


Lys Ala Glu Phe Arg Val Phe Arg Leu Gln Asn Pro Lys Ala Arg Val 
145                 150                 155                 160 


Pro Glu Gln Arg Ile Glu Leu Tyr Gln Ile Leu Lys Ser Lys Asp Leu 
                165                 170                 175     


Thr Ser Pro Thr Gln Arg Tyr Ile Asp Ser Lys Val Val Lys Thr Arg 
            180                 185                 190         


Ala Glu Gly Glu Trp Leu Ser Phe Asp Val Thr Asp Ala Val His Glu 
        195                 200                 205             


Trp Leu His His Lys Asp Arg Asn Leu Gly Phe Lys Ile Ser Leu His 
    210                 215                 220                 


Cys Pro Cys Cys Thr Phe Val Pro Ser Asn Asn Tyr Ile Ile Pro Asn 
225                 230                 235                 240 


Lys Ser Glu Glu Leu Glu Ala Arg Phe Ala Gly Ile Asp Gly Thr Ser 
                245                 250                 255     


Thr Tyr Thr Ser Gly Asp Gln Lys Thr Ile Lys Ser Thr Arg Lys Lys 
            260                 265                 270         


Asn Ser Gly Lys Thr Pro His Leu Leu Leu Met Leu Leu Pro Ser Tyr 
        275                 280                 285             


Arg Leu Glu Ser Gln Gln Thr Asn Arg Arg Lys Lys Arg Ala Leu Asp 
    290                 295                 300                 


Ala Ala Tyr Cys Phe Arg Asn Val Gln Asp Asn Cys Cys Leu Arg Pro 
305                 310                 315                 320 


Leu Tyr Ile Asp Phe Lys Arg Asp Leu Gly Trp Lys Trp Ile His Glu 
                325                 330                 335     


Pro Lys Gly Tyr Asn Ala Asn Phe Cys Ala Gly Ala Cys Pro Tyr Leu 
            340                 345                 350         


Trp Ser Ser Asp Thr Gln His Ser Arg Val Leu Ser Leu Tyr Asn Thr 
        355                 360                 365             


Ile Asn Pro Glu Ala Ser Ala Ser Pro Cys Cys Val Ser Gln Asp Leu 
    370                 375                 380                 


Glu Pro Leu Thr Ile Leu Tyr Tyr Ile Gly Lys Thr Pro Lys Ile Glu 
385                 390                 395                 400 


Gln Leu Ser Asn Met Ile Val Lys Ser Cys Lys Cys Ser 
                405                 410             


<210>  300
<211>  412
<212>  PRT
<213>  Homo sapiens

<400>  300

Met Lys Met His Leu Gln Arg Ala Leu Val Val Leu Ala Leu Leu Asn 
1               5                   10                  15      


Phe Ala Thr Val Ser Leu Ser Leu Ser Thr Cys Thr Thr Leu Asp Phe 
            20                  25                  30          


Gly His Ile Lys Lys Lys Arg Val Glu Ala Ile Arg Gly Gln Ile Leu 
        35                  40                  45              


Ser Lys Leu Arg Leu Thr Ser Pro Pro Glu Pro Thr Val Met Thr His 
    50                  55                  60                  


Val Pro Tyr Gln Val Leu Ala Leu Tyr Asn Ser Thr Arg Glu Leu Leu 
65                  70                  75                  80  


Glu Glu Met His Gly Glu Arg Glu Glu Gly Cys Thr Gln Glu Asn Thr 
                85                  90                  95      


Glu Ser Glu Tyr Tyr Ala Lys Glu Ile His Lys Phe Asp Met Ile Gln 
            100                 105                 110         


Gly Leu Ala Glu His Asn Glu Leu Ala Val Cys Pro Lys Gly Ile Thr 
        115                 120                 125             


Ser Lys Val Phe Arg Phe Asn Val Ser Ser Val Glu Lys Asn Arg Thr 
    130                 135                 140                 


Asn Leu Phe Arg Ala Glu Phe Arg Val Leu Arg Val Pro Asn Pro Ser 
145                 150                 155                 160 


Ser Lys Arg Asn Glu Gln Arg Ile Glu Leu Phe Gln Ile Leu Arg Pro 
                165                 170                 175     


Asp Glu His Ile Ala Lys Gln Arg Tyr Ile Gly Gly Lys Asn Leu Pro 
            180                 185                 190         


Thr Arg Gly Thr Ala Glu Trp Leu Ser Phe Asp Val Thr Asp Thr Val 
        195                 200                 205             


Arg Glu Trp Leu Leu Arg Arg Glu Ser Asn Leu Gly Leu Glu Ile Ser 
    210                 215                 220                 


Ile His Cys Pro Cys His Thr Phe Gln Pro Asn Gly Asp Ile Leu Glu 
225                 230                 235                 240 


Asn Ile His Glu Val Met Glu Ile Lys Phe Lys Gly Val Asp Asn Glu 
                245                 250                 255     


Asp Asp His Gly Arg Gly Asp Leu Gly Arg Leu Lys Lys Gln Lys Asp 
            260                 265                 270         


His His Asn Pro His Leu Ile Leu Met Met Ile Pro Pro His Arg Leu 
        275                 280                 285             


Asp Asn Pro Gly Gln Gly Gly Gln Arg Lys Lys Arg Ala Leu Asp Thr 
    290                 295                 300                 


Asn Tyr Cys Phe Arg Asn Leu Glu Glu Asn Cys Cys Val Arg Pro Leu 
305                 310                 315                 320 


Tyr Ile Asp Phe Arg Gln Asp Leu Gly Trp Lys Trp Val His Glu Pro 
                325                 330                 335     


Lys Gly Tyr Tyr Ala Asn Phe Cys Ser Gly Pro Cys Pro Tyr Leu Arg 
            340                 345                 350         


Ser Ala Asp Thr Thr His Ser Thr Val Leu Gly Leu Tyr Asn Thr Leu 
        355                 360                 365             


Asn Pro Glu Ala Ser Ala Ser Pro Cys Cys Val Pro Gln Asp Leu Glu 
    370                 375                 380                 


Pro Leu Thr Ile Leu Tyr Tyr Val Gly Arg Thr Pro Lys Val Glu Gln 
385                 390                 395                 400 


Leu Ser Asn Met Val Val Lys Ser Cys Lys Cys Ser 
                405                 410         


<210>  301
<211>  503
<212>  PRT
<213>  Homo sapiens

<400>  301

Met Glu Ala Ala Val Ala Ala Pro Arg Pro Arg Leu Leu Leu Leu Val 
1               5                   10                  15      


Leu Ala Ala Ala Ala Ala Ala Ala Ala Ala Leu Leu Pro Gly Ala Thr 
            20                  25                  30          


Ala Leu Gln Cys Phe Cys His Leu Cys Thr Lys Asp Asn Phe Thr Cys 
        35                  40                  45              


Val Thr Asp Gly Leu Cys Phe Val Ser Val Thr Glu Thr Thr Asp Lys 
    50                  55                  60                  


Val Ile His Asn Ser Met Cys Ile Ala Glu Ile Asp Leu Ile Pro Arg 
65                  70                  75                  80  


Asp Arg Pro Phe Val Cys Ala Pro Ser Ser Lys Thr Gly Ser Val Thr 
                85                  90                  95      


Thr Thr Tyr Cys Cys Asn Gln Asp His Cys Asn Lys Ile Glu Leu Pro 
            100                 105                 110         


Thr Thr Val Lys Ser Ser Pro Gly Leu Gly Pro Val Glu Leu Ala Ala 
        115                 120                 125             


Val Ile Ala Gly Pro Val Cys Phe Val Cys Ile Ser Leu Met Leu Met 
    130                 135                 140                 


Val Tyr Ile Cys His Asn Arg Thr Val Ile His His Arg Val Pro Asn 
145                 150                 155                 160 


Glu Glu Asp Pro Ser Leu Asp Arg Pro Phe Ile Ser Glu Gly Thr Thr 
                165                 170                 175     


Leu Lys Asp Leu Ile Tyr Asp Met Thr Thr Ser Gly Ser Gly Ser Gly 
            180                 185                 190         


Leu Pro Leu Leu Val Gln Arg Thr Ile Ala Arg Thr Ile Val Leu Gln 
        195                 200                 205             


Glu Ser Ile Gly Lys Gly Arg Phe Gly Glu Val Trp Arg Gly Lys Trp 
    210                 215                 220                 


Arg Gly Glu Glu Val Ala Val Lys Ile Phe Ser Ser Arg Glu Glu Arg 
225                 230                 235                 240 


Ser Trp Phe Arg Glu Ala Glu Ile Tyr Gln Thr Val Met Leu Arg His 
                245                 250                 255     


Glu Asn Ile Leu Gly Phe Ile Ala Ala Asp Asn Lys Asp Asn Gly Thr 
            260                 265                 270         


Trp Thr Gln Leu Trp Leu Val Ser Asp Tyr His Glu His Gly Ser Leu 
        275                 280                 285             


Phe Asp Tyr Leu Asn Arg Tyr Thr Val Thr Val Glu Gly Met Ile Lys 
    290                 295                 300                 


Leu Ala Leu Ser Thr Ala Ser Gly Leu Ala His Leu His Met Glu Ile 
305                 310                 315                 320 


Val Gly Thr Gln Gly Lys Pro Ala Ile Ala His Arg Asp Leu Lys Ser 
                325                 330                 335     


Lys Asn Ile Leu Val Lys Lys Asn Gly Thr Cys Cys Ile Ala Asp Leu 
            340                 345                 350         


Gly Leu Ala Val Arg His Asp Ser Ala Thr Asp Thr Ile Asp Ile Ala 
        355                 360                 365             


Pro Asn His Arg Val Gly Thr Lys Arg Tyr Met Ala Pro Glu Val Leu 
    370                 375                 380                 


Asp Asp Ser Ile Asn Met Lys His Phe Glu Ser Phe Lys Arg Ala Asp 
385                 390                 395                 400 


Ile Tyr Ala Met Gly Leu Val Phe Trp Glu Ile Ala Arg Arg Cys Ser 
                405                 410                 415     


Ile Gly Gly Ile His Glu Asp Tyr Gln Leu Pro Tyr Tyr Asp Leu Val 
            420                 425                 430         


Pro Ser Asp Pro Ser Val Glu Glu Met Arg Lys Val Val Cys Glu Gln 
        435                 440                 445             


Lys Leu Arg Pro Asn Ile Pro Asn Arg Trp Gln Ser Cys Glu Ala Leu 
    450                 455                 460                 


Arg Val Met Ala Lys Ile Met Arg Glu Cys Trp Tyr Ala Asn Gly Ala 
465                 470                 475                 480 


Ala Arg Leu Thr Ala Leu Arg Ile Lys Lys Thr Leu Ser Gln Leu Ser 
                485                 490                 495     


Gln Gln Glu Gly Ile Lys Met 
            500             


<210>  302
<211>  592
<212>  PRT
<213>  Homo sapiens

<400>  302

Met Gly Arg Gly Leu Leu Arg Gly Leu Trp Pro Leu His Ile Val Leu 
1               5                   10                  15      


Trp Thr Arg Ile Ala Ser Thr Ile Pro Pro His Val Gln Lys Ser Asp 
            20                  25                  30          


Val Glu Met Glu Ala Gln Lys Asp Glu Ile Ile Cys Pro Ser Cys Asn 
        35                  40                  45              


Arg Thr Ala His Pro Leu Arg His Ile Asn Asn Asp Met Ile Val Thr 
    50                  55                  60                  


Asp Asn Asn Gly Ala Val Lys Phe Pro Gln Leu Cys Lys Phe Cys Asp 
65                  70                  75                  80  


Val Arg Phe Ser Thr Cys Asp Asn Gln Lys Ser Cys Met Ser Asn Cys 
                85                  90                  95      


Ser Ile Thr Ser Ile Cys Glu Lys Pro Gln Glu Val Cys Val Ala Val 
            100                 105                 110         


Trp Arg Lys Asn Asp Glu Asn Ile Thr Leu Glu Thr Val Cys His Asp 
        115                 120                 125             


Pro Lys Leu Pro Tyr His Asp Phe Ile Leu Glu Asp Ala Ala Ser Pro 
    130                 135                 140                 


Lys Cys Ile Met Lys Glu Lys Lys Lys Pro Gly Glu Thr Phe Phe Met 
145                 150                 155                 160 


Cys Ser Cys Ser Ser Asp Glu Cys Asn Asp Asn Ile Ile Phe Ser Glu 
                165                 170                 175     


Glu Tyr Asn Thr Ser Asn Pro Asp Leu Leu Leu Val Ile Phe Gln Val 
            180                 185                 190         


Thr Gly Ile Ser Leu Leu Pro Pro Leu Gly Val Ala Ile Ser Val Ile 
        195                 200                 205             


Ile Ile Phe Tyr Cys Tyr Arg Val Asn Arg Gln Gln Lys Leu Ser Ser 
    210                 215                 220                 


Thr Trp Glu Thr Gly Lys Thr Arg Lys Leu Met Glu Phe Ser Glu His 
225                 230                 235                 240 


Cys Ala Ile Ile Leu Glu Asp Asp Arg Ser Asp Ile Ser Ser Thr Cys 
                245                 250                 255     


Ala Asn Asn Ile Asn His Asn Thr Glu Leu Leu Pro Ile Glu Leu Asp 
            260                 265                 270         


Thr Leu Val Gly Lys Gly Arg Phe Ala Glu Val Tyr Lys Ala Lys Leu 
        275                 280                 285             


Lys Gln Asn Thr Ser Glu Gln Phe Glu Thr Val Ala Val Lys Ile Phe 
    290                 295                 300                 


Pro Tyr Glu Glu Tyr Ala Ser Trp Lys Thr Glu Lys Asp Ile Phe Ser 
305                 310                 315                 320 


Asp Ile Asn Leu Lys His Glu Asn Ile Leu Gln Phe Leu Thr Ala Glu 
                325                 330                 335     


Glu Arg Lys Thr Glu Leu Gly Lys Gln Tyr Trp Leu Ile Thr Ala Phe 
            340                 345                 350         


His Ala Lys Gly Asn Leu Gln Glu Tyr Leu Thr Arg His Val Ile Ser 
        355                 360                 365             


Trp Glu Asp Leu Arg Lys Leu Gly Ser Ser Leu Ala Arg Gly Ile Ala 
    370                 375                 380                 


His Leu His Ser Asp His Thr Pro Cys Gly Arg Pro Lys Met Pro Ile 
385                 390                 395                 400 


Val His Arg Asp Leu Lys Ser Ser Asn Ile Leu Val Lys Asn Asp Leu 
                405                 410                 415     


Thr Cys Cys Leu Cys Asp Phe Gly Leu Ser Leu Arg Leu Asp Pro Thr 
            420                 425                 430         


Leu Ser Val Asp Asp Leu Ala Asn Ser Gly Gln Val Gly Thr Ala Arg 
        435                 440                 445             


Tyr Met Ala Pro Glu Val Leu Glu Ser Arg Met Asn Leu Glu Asn Val 
    450                 455                 460                 


Glu Ser Phe Lys Gln Thr Asp Val Tyr Ser Met Ala Leu Val Leu Trp 
465                 470                 475                 480 


Glu Met Thr Ser Arg Cys Asn Ala Val Gly Glu Val Lys Asp Tyr Glu 
                485                 490                 495     


Pro Pro Phe Gly Ser Lys Val Arg Glu His Pro Cys Val Glu Ser Met 
            500                 505                 510         


Lys Asp Asn Val Leu Arg Asp Arg Gly Arg Pro Glu Ile Pro Ser Phe 
        515                 520                 525             


Trp Leu Asn His Gln Gly Ile Gln Met Val Cys Glu Thr Leu Thr Glu 
    530                 535                 540                 


Cys Trp Asp His Asp Pro Glu Ala Arg Leu Thr Ala Gln Cys Val Ala 
545                 550                 555                 560 


Glu Arg Phe Ser Glu Leu Glu His Leu Asp Arg Leu Ser Gly Arg Ser 
                565                 570                 575     


Cys Ser Glu Glu Lys Ile Pro Glu Asp Gly Ser Leu Asn Thr Thr Lys 
            580                 585                 590         


<210>  303
<211>  567
<212>  PRT
<213>  Homo sapiens

<400>  303

Met Gly Arg Gly Leu Leu Arg Gly Leu Trp Pro Leu His Ile Val Leu 
1               5                   10                  15      


Trp Thr Arg Ile Ala Ser Thr Ile Pro Pro His Val Gln Lys Ser Val 
            20                  25                  30          


Asn Asn Asp Met Ile Val Thr Asp Asn Asn Gly Ala Val Lys Phe Pro 
        35                  40                  45              


Gln Leu Cys Lys Phe Cys Asp Val Arg Phe Ser Thr Cys Asp Asn Gln 
    50                  55                  60                  


Lys Ser Cys Met Ser Asn Cys Ser Ile Thr Ser Ile Cys Glu Lys Pro 
65                  70                  75                  80  


Gln Glu Val Cys Val Ala Val Trp Arg Lys Asn Asp Glu Asn Ile Thr 
                85                  90                  95      


Leu Glu Thr Val Cys His Asp Pro Lys Leu Pro Tyr His Asp Phe Ile 
            100                 105                 110         


Leu Glu Asp Ala Ala Ser Pro Lys Cys Ile Met Lys Glu Lys Lys Lys 
        115                 120                 125             


Pro Gly Glu Thr Phe Phe Met Cys Ser Cys Ser Ser Asp Glu Cys Asn 
    130                 135                 140                 


Asp Asn Ile Ile Phe Ser Glu Glu Tyr Asn Thr Ser Asn Pro Asp Leu 
145                 150                 155                 160 


Leu Leu Val Ile Phe Gln Val Thr Gly Ile Ser Leu Leu Pro Pro Leu 
                165                 170                 175     


Gly Val Ala Ile Ser Val Ile Ile Ile Phe Tyr Cys Tyr Arg Val Asn 
            180                 185                 190         


Arg Gln Gln Lys Leu Ser Ser Thr Trp Glu Thr Gly Lys Thr Arg Lys 
        195                 200                 205             


Leu Met Glu Phe Ser Glu His Cys Ala Ile Ile Leu Glu Asp Asp Arg 
    210                 215                 220                 


Ser Asp Ile Ser Ser Thr Cys Ala Asn Asn Ile Asn His Asn Thr Glu 
225                 230                 235                 240 


Leu Leu Pro Ile Glu Leu Asp Thr Leu Val Gly Lys Gly Arg Phe Ala 
                245                 250                 255     


Glu Val Tyr Lys Ala Lys Leu Lys Gln Asn Thr Ser Glu Gln Phe Glu 
            260                 265                 270         


Thr Val Ala Val Lys Ile Phe Pro Tyr Glu Glu Tyr Ala Ser Trp Lys 
        275                 280                 285             


Thr Glu Lys Asp Ile Phe Ser Asp Ile Asn Leu Lys His Glu Asn Ile 
    290                 295                 300                 


Leu Gln Phe Leu Thr Ala Glu Glu Arg Lys Thr Glu Leu Gly Lys Gln 
305                 310                 315                 320 


Tyr Trp Leu Ile Thr Ala Phe His Ala Lys Gly Asn Leu Gln Glu Tyr 
                325                 330                 335     


Leu Thr Arg His Val Ile Ser Trp Glu Asp Leu Arg Lys Leu Gly Ser 
            340                 345                 350         


Ser Leu Ala Arg Gly Ile Ala His Leu His Ser Asp His Thr Pro Cys 
        355                 360                 365             


Gly Arg Pro Lys Met Pro Ile Val His Arg Asp Leu Lys Ser Ser Asn 
    370                 375                 380                 


Ile Leu Val Lys Asn Asp Leu Thr Cys Cys Leu Cys Asp Phe Gly Leu 
385                 390                 395                 400 


Ser Leu Arg Leu Asp Pro Thr Leu Ser Val Asp Asp Leu Ala Asn Ser 
                405                 410                 415     


Gly Gln Val Gly Thr Ala Arg Tyr Met Ala Pro Glu Val Leu Glu Ser 
            420                 425                 430         


Arg Met Asn Leu Glu Asn Val Glu Ser Phe Lys Gln Thr Asp Val Tyr 
        435                 440                 445             


Ser Met Ala Leu Val Leu Trp Glu Met Thr Ser Arg Cys Asn Ala Val 
    450                 455                 460                 


Gly Glu Val Lys Asp Tyr Glu Pro Pro Phe Gly Ser Lys Val Arg Glu 
465                 470                 475                 480 


His Pro Cys Val Glu Ser Met Lys Asp Asn Val Leu Arg Asp Arg Gly 
                485                 490                 495     


Arg Pro Glu Ile Pro Ser Phe Trp Leu Asn His Gln Gly Ile Gln Met 
            500                 505                 510         


Val Cys Glu Thr Leu Thr Glu Cys Trp Asp His Asp Pro Glu Ala Arg 
        515                 520                 525             


Leu Thr Ala Gln Cys Val Ala Glu Arg Phe Ser Glu Leu Glu His Leu 
    530                 535                 540                 


Asp Arg Leu Ser Gly Arg Ser Cys Ser Glu Glu Lys Ile Pro Glu Asp 
545                 550                 555                 560 


Gly Ser Leu Asn Thr Thr Lys 
                565         


<210>  304
<211>  111
<212>  PRT
<213>  Homo sapiens

<400>  304

Gln Leu Cys Lys Phe Cys Asp Val Arg Phe Ser Thr Cys Asp Asn Gln 
1               5                   10                  15      


Lys Ser Cys Met Ser Asn Cys Ser Ile Thr Ser Ile Cys Glu Lys Pro 
            20                  25                  30          


Gln Glu Val Cys Val Ala Val Trp Arg Lys Asn Asp Glu Asn Ile Thr 
        35                  40                  45              


Leu Glu Thr Val Cys His Asp Pro Lys Leu Pro Tyr His Asp Phe Ile 
    50                  55                  60                  


Leu Glu Asp Ala Ala Ser Pro Lys Cys Ile Met Lys Glu Lys Lys Lys 
65                  70                  75                  80  


Pro Gly Glu Thr Phe Phe Met Cys Ser Cys Ser Ser Ala Glu Cys Asn 
                85                  90                  95      


Asp Asn Ile Ile Phe Ser Glu Glu Tyr Asn Thr Ser Asn Pro Asp 
            100                 105                 110     


<210>  305
<211>  851
<212>  PRT
<213>  Homo sapiens

<400>  305

Met Thr Ser His Tyr Val Ile Ala Ile Phe Ala Leu Met Ser Ser Cys 
1               5                   10                  15      


Leu Ala Thr Ala Gly Pro Glu Pro Gly Ala Leu Cys Glu Leu Ser Pro 
            20                  25                  30          


Val Ser Ala Ser His Pro Val Gln Ala Leu Met Glu Ser Phe Thr Val 
        35                  40                  45              


Leu Ser Gly Cys Ala Ser Arg Gly Thr Thr Gly Leu Pro Gln Glu Val 
    50                  55                  60                  


His Val Leu Asn Leu Arg Thr Ala Gly Gln Gly Pro Gly Gln Leu Gln 
65                  70                  75                  80  


Arg Glu Val Thr Leu His Leu Asn Pro Ile Ser Ser Val His Ile His 
                85                  90                  95      


His Lys Ser Val Val Phe Leu Leu Asn Ser Pro His Pro Leu Val Trp 
            100                 105                 110         


His Leu Lys Thr Glu Arg Leu Ala Thr Gly Val Ser Arg Leu Phe Leu 
        115                 120                 125             


Val Ser Glu Gly Ser Val Val Gln Phe Ser Ser Ala Asn Phe Ser Leu 
    130                 135                 140                 


Thr Ala Glu Thr Glu Glu Arg Asn Phe Pro His Gly Asn Glu His Leu 
145                 150                 155                 160 


Leu Asn Trp Ala Arg Lys Glu Tyr Gly Ala Val Thr Ser Phe Thr Glu 
                165                 170                 175     


Leu Lys Ile Ala Arg Asn Ile Tyr Ile Lys Val Gly Glu Asp Gln Val 
            180                 185                 190         


Phe Pro Pro Lys Cys Asn Ile Gly Lys Asn Phe Leu Ser Leu Asn Tyr 
        195                 200                 205             


Leu Ala Glu Tyr Leu Gln Pro Lys Ala Ala Glu Gly Cys Val Met Ser 
    210                 215                 220                 


Ser Gln Pro Gln Asn Glu Glu Val His Ile Ile Glu Leu Ile Thr Pro 
225                 230                 235                 240 


Asn Ser Asn Pro Tyr Ser Ala Phe Gln Val Asp Ile Thr Ile Asp Ile 
                245                 250                 255     


Arg Pro Ser Gln Glu Asp Leu Glu Val Val Lys Asn Leu Ile Leu Ile 
            260                 265                 270         


Leu Lys Cys Lys Lys Ser Val Asn Trp Val Ile Lys Ser Phe Asp Val 
        275                 280                 285             


Lys Gly Ser Leu Lys Ile Ile Ala Pro Asn Ser Ile Gly Phe Gly Lys 
    290                 295                 300                 


Glu Ser Glu Arg Ser Met Thr Met Thr Lys Ser Ile Arg Asp Asp Ile 
305                 310                 315                 320 


Pro Ser Thr Gln Gly Asn Leu Val Lys Trp Ala Leu Asp Asn Gly Tyr 
                325                 330                 335     


Ser Pro Ile Thr Ser Tyr Thr Met Ala Pro Val Ala Asn Arg Phe His 
            340                 345                 350         


Leu Arg Leu Glu Asn Asn Ala Glu Glu Met Gly Asp Glu Glu Val His 
        355                 360                 365             


Thr Ile Pro Pro Glu Leu Arg Ile Leu Leu Asp Pro Gly Ala Leu Pro 
    370                 375                 380                 


Ala Leu Gln Asn Pro Pro Ile Arg Gly Gly Glu Gly Gln Asn Gly Gly 
385                 390                 395                 400 


Leu Pro Phe Pro Phe Pro Asp Ile Ser Arg Arg Val Trp Asn Glu Glu 
                405                 410                 415     


Gly Glu Asp Gly Leu Pro Arg Pro Lys Asp Pro Val Ile Pro Ser Ile 
            420                 425                 430         


Gln Leu Phe Pro Gly Leu Arg Glu Pro Glu Glu Val Gln Gly Ser Val 
        435                 440                 445             


Asp Ile Ala Leu Ser Val Lys Cys Asp Asn Glu Lys Met Ile Val Ala 
    450                 455                 460                 


Val Glu Lys Asp Ser Phe Gln Ala Ser Gly Tyr Ser Gly Met Asp Val 
465                 470                 475                 480 


Thr Leu Leu Asp Pro Thr Cys Lys Ala Lys Met Asn Gly Thr His Phe 
                485                 490                 495     


Val Leu Glu Ser Pro Leu Asn Gly Cys Gly Thr Arg Pro Arg Trp Ser 
            500                 505                 510         


Ala Leu Asp Gly Val Val Tyr Tyr Asn Ser Ile Val Ile Gln Val Pro 
        515                 520                 525             


Ala Leu Gly Asp Ser Ser Gly Trp Pro Asp Gly Tyr Glu Asp Leu Glu 
    530                 535                 540                 


Ser Gly Asp Asn Gly Phe Pro Gly Asp Met Asp Glu Gly Asp Ala Ser 
545                 550                 555                 560 


Leu Phe Thr Arg Pro Glu Ile Val Val Phe Asn Cys Ser Leu Gln Gln 
                565                 570                 575     


Val Arg Asn Pro Ser Ser Phe Gln Glu Gln Pro His Gly Asn Ile Thr 
            580                 585                 590         


Phe Asn Met Glu Leu Tyr Asn Thr Asp Leu Phe Leu Val Pro Ser Gln 
        595                 600                 605             


Gly Val Phe Ser Val Pro Glu Asn Gly His Val Tyr Val Glu Val Ser 
    610                 615                 620                 


Val Thr Lys Ala Glu Gln Glu Leu Gly Phe Ala Ile Gln Thr Cys Phe 
625                 630                 635                 640 


Ile Ser Pro Tyr Ser Asn Pro Asp Arg Met Ser His Tyr Thr Ile Ile 
                645                 650                 655     


Glu Asn Ile Cys Pro Lys Asp Glu Ser Val Lys Phe Tyr Ser Pro Lys 
            660                 665                 670         


Arg Val His Phe Pro Ile Pro Gln Ala Asp Met Asp Lys Lys Arg Phe 
        675                 680                 685             


Ser Phe Val Phe Lys Pro Val Phe Asn Thr Ser Leu Leu Phe Leu Gln 
    690                 695                 700                 


Cys Glu Leu Thr Leu Cys Thr Lys Met Glu Lys His Pro Gln Lys Leu 
705                 710                 715                 720 


Pro Lys Cys Val Pro Pro Asp Glu Ala Cys Thr Ser Leu Asp Ala Ser 
                725                 730                 735     


Ile Ile Trp Ala Met Met Gln Asn Lys Lys Thr Phe Thr Lys Pro Leu 
            740                 745                 750         


Ala Val Ile His His Glu Ala Glu Ser Lys Glu Lys Gly Pro Ser Met 
        755                 760                 765             


Lys Glu Pro Asn Pro Ile Ser Pro Pro Ile Phe His Gly Leu Asp Thr 
    770                 775                 780                 


Leu Thr Val Met Gly Ile Ala Phe Ala Ala Phe Val Ile Gly Ala Leu 
785                 790                 795                 800 


Leu Thr Gly Ala Leu Trp Tyr Ile Tyr Ser His Thr Gly Glu Thr Ala 
                805                 810                 815     


Gly Arg Gln Gln Val Pro Thr Ser Pro Pro Ala Ser Glu Asn Ser Ser 
            820                 825                 830         


Ala Ala His Ser Ile Gly Ser Thr Gln Ser Thr Pro Cys Ser Ser Ser 
        835                 840                 845             


Ser Thr Ala 
    850     


<210>  306
<211>  850
<212>  PRT
<213>  Homo sapiens

<400>  306

Met Thr Ser His Tyr Val Ile Ala Ile Phe Ala Leu Met Ser Ser Cys 
1               5                   10                  15      


Leu Ala Thr Ala Gly Pro Glu Pro Gly Ala Leu Cys Glu Leu Ser Pro 
            20                  25                  30          


Val Ser Ala Ser His Pro Val Gln Ala Leu Met Glu Ser Phe Thr Val 
        35                  40                  45              


Leu Ser Gly Cys Ala Ser Arg Gly Thr Thr Gly Leu Pro Gln Glu Val 
    50                  55                  60                  


His Val Leu Asn Leu Arg Thr Ala Gly Gln Gly Pro Gly Gln Leu Gln 
65                  70                  75                  80  


Arg Glu Val Thr Leu His Leu Asn Pro Ile Ser Ser Val His Ile His 
                85                  90                  95      


His Lys Ser Val Val Phe Leu Leu Asn Ser Pro His Pro Leu Val Trp 
            100                 105                 110         


His Leu Lys Thr Glu Arg Leu Ala Thr Gly Val Ser Arg Leu Phe Leu 
        115                 120                 125             


Val Ser Glu Gly Ser Val Val Gln Phe Ser Ser Ala Asn Phe Ser Leu 
    130                 135                 140                 


Thr Ala Glu Thr Glu Glu Arg Asn Phe Pro His Gly Asn Glu His Leu 
145                 150                 155                 160 


Leu Asn Trp Ala Arg Lys Glu Tyr Gly Ala Val Thr Ser Phe Thr Glu 
                165                 170                 175     


Leu Lys Ile Ala Arg Asn Ile Tyr Ile Lys Val Gly Glu Asp Gln Val 
            180                 185                 190         


Phe Pro Pro Lys Cys Asn Ile Gly Lys Asn Phe Leu Ser Leu Asn Tyr 
        195                 200                 205             


Leu Ala Glu Tyr Leu Gln Pro Lys Ala Ala Glu Gly Cys Val Met Ser 
    210                 215                 220                 


Ser Gln Pro Gln Asn Glu Glu Val His Ile Ile Glu Leu Ile Thr Pro 
225                 230                 235                 240 


Asn Ser Asn Pro Tyr Ser Ala Phe Gln Val Asp Ile Thr Ile Asp Ile 
                245                 250                 255     


Arg Pro Ser Gln Glu Asp Leu Glu Val Val Lys Asn Leu Ile Leu Ile 
            260                 265                 270         


Leu Lys Cys Lys Lys Ser Val Asn Trp Val Ile Lys Ser Phe Asp Val 
        275                 280                 285             


Lys Gly Ser Leu Lys Ile Ile Ala Pro Asn Ser Ile Gly Phe Gly Lys 
    290                 295                 300                 


Glu Ser Glu Arg Ser Met Thr Met Thr Lys Ser Ile Arg Asp Asp Ile 
305                 310                 315                 320 


Pro Ser Thr Gln Gly Asn Leu Val Lys Trp Ala Leu Asp Asn Gly Tyr 
                325                 330                 335     


Ser Pro Ile Thr Ser Tyr Thr Met Ala Pro Val Ala Asn Arg Phe His 
            340                 345                 350         


Leu Arg Leu Glu Asn Asn Glu Glu Met Gly Asp Glu Glu Val His Thr 
        355                 360                 365             


Ile Pro Pro Glu Leu Arg Ile Leu Leu Asp Pro Gly Ala Leu Pro Ala 
    370                 375                 380                 


Leu Gln Asn Pro Pro Ile Arg Gly Gly Glu Gly Gln Asn Gly Gly Leu 
385                 390                 395                 400 


Pro Phe Pro Phe Pro Asp Ile Ser Arg Arg Val Trp Asn Glu Glu Gly 
                405                 410                 415     


Glu Asp Gly Leu Pro Arg Pro Lys Asp Pro Val Ile Pro Ser Ile Gln 
            420                 425                 430         


Leu Phe Pro Gly Leu Arg Glu Pro Glu Glu Val Gln Gly Ser Val Asp 
        435                 440                 445             


Ile Ala Leu Ser Val Lys Cys Asp Asn Glu Lys Met Ile Val Ala Val 
    450                 455                 460                 


Glu Lys Asp Ser Phe Gln Ala Ser Gly Tyr Ser Gly Met Asp Val Thr 
465                 470                 475                 480 


Leu Leu Asp Pro Thr Cys Lys Ala Lys Met Asn Gly Thr His Phe Val 
                485                 490                 495     


Leu Glu Ser Pro Leu Asn Gly Cys Gly Thr Arg Pro Arg Trp Ser Ala 
            500                 505                 510         


Leu Asp Gly Val Val Tyr Tyr Asn Ser Ile Val Ile Gln Val Pro Ala 
        515                 520                 525             


Leu Gly Asp Ser Ser Gly Trp Pro Asp Gly Tyr Glu Asp Leu Glu Ser 
    530                 535                 540                 


Gly Asp Asn Gly Phe Pro Gly Asp Met Asp Glu Gly Asp Ala Ser Leu 
545                 550                 555                 560 


Phe Thr Arg Pro Glu Ile Val Val Phe Asn Cys Ser Leu Gln Gln Val 
                565                 570                 575     


Arg Asn Pro Ser Ser Phe Gln Glu Gln Pro His Gly Asn Ile Thr Phe 
            580                 585                 590         


Asn Met Glu Leu Tyr Asn Thr Asp Leu Phe Leu Val Pro Ser Gln Gly 
        595                 600                 605             


Val Phe Ser Val Pro Glu Asn Gly His Val Tyr Val Glu Val Ser Val 
    610                 615                 620                 


Thr Lys Ala Glu Gln Glu Leu Gly Phe Ala Ile Gln Thr Cys Phe Ile 
625                 630                 635                 640 


Ser Pro Tyr Ser Asn Pro Asp Arg Met Ser His Tyr Thr Ile Ile Glu 
                645                 650                 655     


Asn Ile Cys Pro Lys Asp Glu Ser Val Lys Phe Tyr Ser Pro Lys Arg 
            660                 665                 670         


Val His Phe Pro Ile Pro Gln Ala Asp Met Asp Lys Lys Arg Phe Ser 
        675                 680                 685             


Phe Val Phe Lys Pro Val Phe Asn Thr Ser Leu Leu Phe Leu Gln Cys 
    690                 695                 700                 


Glu Leu Thr Leu Cys Thr Lys Met Glu Lys His Pro Gln Lys Leu Pro 
705                 710                 715                 720 


Lys Cys Val Pro Pro Asp Glu Ala Cys Thr Ser Leu Asp Ala Ser Ile 
                725                 730                 735     


Ile Trp Ala Met Met Gln Asn Lys Lys Thr Phe Thr Lys Pro Leu Ala 
            740                 745                 750         


Val Ile His His Glu Ala Glu Ser Lys Glu Lys Gly Pro Ser Met Lys 
        755                 760                 765             


Glu Pro Asn Pro Ile Ser Pro Pro Ile Phe His Gly Leu Asp Thr Leu 
    770                 775                 780                 


Thr Val Met Gly Ile Ala Phe Ala Ala Phe Val Ile Gly Ala Leu Leu 
785                 790                 795                 800 


Thr Gly Ala Leu Trp Tyr Ile Tyr Ser His Thr Gly Glu Thr Ala Gly 
                805                 810                 815     


Arg Gln Gln Val Pro Thr Ser Pro Pro Ala Ser Glu Asn Ser Ser Ala 
            820                 825                 830         


Ala His Ser Ile Gly Ser Thr Gln Ser Thr Pro Cys Ser Ser Ser Ser 
        835                 840                 845             


Thr Ala 
    850 


<210>  307
<211>  8
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Strep Tag

<400>  307

Trp Ser His Pro Gln Phe Glu Lys 
1               5               


<210>  308
<211>  248
<212>  PRT
<213>  Homo sapiens

<400>  308

Gln Leu Cys Lys Phe Cys Asp Val Arg Phe Ser Thr Cys Asp Asn Gln 
1               5                   10                  15      


Lys Ser Cys Met Ser Asn Cys Ser Ile Thr Ser Ile Cys Glu Lys Pro 
            20                  25                  30          


Gln Glu Val Cys Val Ala Val Trp Arg Lys Asn Asp Glu Asn Ile Thr 
        35                  40                  45              


Leu Glu Thr Val Cys His Asp Pro Lys Leu Pro Tyr His Asp Phe Ile 
    50                  55                  60                  


Leu Glu Asp Ala Ala Ser Pro Lys Cys Ile Met Lys Glu Lys Lys Lys 
65                  70                  75                  80  


Pro Gly Glu Thr Phe Phe Met Cys Ser Cys Ser Ser Ala Glu Cys Asn 
                85                  90                  95      


Asp Asn Ile Ile Phe Ser Glu Glu Tyr Asn Thr Ser Asn Pro Asp Gly 
            100                 105                 110         


Gly Gly Gly Ser Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser Gly Gly 
        115                 120                 125             


Gly Gly Ser Gly Gly Gly Gly Ser Ala Leu Asp Thr Asn Tyr Cys Phe 
    130                 135                 140                 


Arg Asn Leu Glu Glu Asn Cys Cys Val Arg Pro Leu Tyr Ile Asp Phe 
145                 150                 155                 160 


Arg Gln Asp Leu Gly Trp Lys Trp Val His Glu Pro Lys Gly Tyr Tyr 
                165                 170                 175     


Ala Asn Phe Cys Ser Gly Pro Cys Pro Tyr Leu Arg Ser Ala Asp Thr 
            180                 185                 190         


Thr His Ser Thr Val Leu Gly Leu Tyr Asn Thr Leu Asn Pro Glu Ala 
        195                 200                 205             


Ser Ala Ser Pro Ser Cys Val Pro Gln Asp Leu Glu Pro Leu Thr Ile 
    210                 215                 220                 


Leu Tyr Tyr Val Gly Arg Thr Pro Lys Val Glu Gln Leu Ser Asn Met 
225                 230                 235                 240 


Val Val Lys Ser Cys Lys Cys Ser 
                245             


