                         SEQUENCE LISTING

<110> WALKING FISH THERAPEUTICS
 
<120> ENGINEERING B CELL-BASED PROTEIN FACTORIES TO TREAT SERIOUS 
      DISEASES

<130> 2219235.00121WO1

<140> PCT/US2022/025471
<141> 2022-04-20

<150> 63/176,944
<151> 2021-04-20

<160> 31    

<170> PatentIn version 3.5

<210> 1
<211> 7361
<212> DNA
<213> Homo sapiens

<400> 1
attcctgaag ctgacagcat tcgggccgag atgtctcgct ccgtggcctt agctgtgctc       60

gcgctactct ctctttctgg cctggaggct atccagcgtg agtctctcct accctcccgc      120

tctggtcctt cctctcccgc tctgcaccct ctgtggccct cgctgtgctc tctcgctccg      180

tgacttccct tctccaagtt ctccttggtg gcccgccgtg gggctagtcc agggctggat      240

ctcggggaag cggcggggtg gcctgggagt ggggaagggg gtgcgcaccc gggacgcgcg      300

ctacttgccc ctttcggcgg ggagcagggg agacctttgg cctacggcga cgggagggtc      360

gggacaaagt ttagggcgtc gataagcgtc agagcgccga ggttggggga gggtttctct      420

tccgctcttt cgcggggcct ctggctcccc cagcgcagct ggagtggggg acgggtaggc      480

tcgtcccaaa ggcgcggcgc tgaggtttgt gaacgcgtgg aggggcgctt ggggtctggg      540

ggaggcgtcg cccgggtaag cctgtctgct gcggctctgc ttcccttaga ctggagagct      600

gtggacttcg tctaggcgcc cgctaagttc gcatgtccta gcacctctgg gtctatgtgg      660

ggccacaccg tggggaggaa acagcacgcg acgtttgtag aatgcttggc tgtgatacaa      720

agcggtttcg aataattaac ttatttgttc ccatcacatg tcacttttaa aaaattataa      780

gaactacccg ttattgacat ctttctgtgt gccaaggact ttatgtgctt tgcgtcattt      840

aattttgaaa acagttatct tccgccatag ataactacta tggttatctt ctgcctctca      900

cagatgaaga aactaaggca ccgagatttt aagaaactta attacacagg ggataaatgg      960

cagcaatcga gattgaagtc aagcctaacc agggcttttg cgggagcgca tgccttttgg     1020

ctgtaattcg tgcatttttt tttaagaaaa acgcctgcct tctgcgtgag attctccaga     1080

gcaaactggg cggcatgggc cctgtggtct tttcgtacag agggcttcct ctttggctct     1140

ttgcctggtt gtttccaaga tgtactgtgc ctcttacttt cggttttgaa aacatgaggg     1200

ggttgggcgt ggtagcttac gcctgtaatc ccagcactta gggaggccga ggcgggagga     1260

tggcttgagg tccgtagttg agaccagcct ggccaacatg gtgaagcctg gtctctacaa     1320

aaaataataa caaaaattag ccgggtgtgg tggctcgtgc ctgtggtccc agctgctccg     1380

gtggctgagg cgggaggatc tcttgagctt aggcttttga gctatcatgg cgccagtgca     1440

ctccagcgtg ggcaacagag cgagaccctg tctctcaaaa aagaaaaaaa aaaaaaaaga     1500

aagagaaaag aaaagaaaga aagaagtgaa ggtttgtcag tcaggggagc tgtaaaacca     1560

ttaataaaga taatccaaga tggttaccaa gactgttgag gacgccagag atcttgagca     1620

ctttctaagt acctggcaat acactaagcg cgctcacctt ttcctctggc aaaacatgat     1680

cgaaagcaga atgttttgat catgagaaaa ttgcatttaa tttgaataca atttatttac     1740

aacataaagg ataatgtata tatcaccacc attactggta tttgctggtt atgttagatg     1800

tcattttaaa aaataacaat ctgatattta aaaaaaaatc ttattttgaa aatttccaaa     1860

gtaatacatg ccatgcatag accatttctg gaagatacca caagaaacat gtaatgatga     1920

ttgcctctga aggtctattt tcctcctctg acctgtgtgt gggttttgtt tttgttttac     1980

tgtgggcata aattaatttt tcagttaagt tttggaagct taaataactc tccaaaagtc     2040

ataaagccag taactggttg agcccaaatt caaacccagc ctgtctgata cttgtcctct     2100

tcttagaaaa gattacagtg atgctctcac aaaatcttgc cgccttccct caaacagaga     2160

gttccaggca ggatgaatct gtgctctgat ccctgaggca tttaatatgt tcttattatt     2220

agaagctcag atgcaaagag ctctcttagc ttttaatgtt atgaaaaaaa tcaggtcttc     2280

attagattcc ccaatccacc tcttgatggg gctagtagcc tttccttaat gatagggtgt     2340

ttctagagag atatatctgg tcaaggtggc ctggtactcc tccttctccc cacagcctcc     2400

cagacaagga ggagtagctg ccttttagtg atcatgtacc ctgaatataa gtgtatttaa     2460

aagaatttta tacacatata tttagtgtca atctgtatat ttagtagcac taacacttct     2520

cttcattttc aatgaaaaat atagagttta taatattttc ttcccacttc cccatggatg     2580

gtctagtcat gcctctcatt ttggaaagta ctgtttctga aacattaggc aatatattcc     2640

caacctggct agtttacagc aatcacctgt ggatgctaat taaaacgcaa atcccactgt     2700

cacatgcatt actccatttg atcataatgg aaagtatgtt ctgtcccatt tgccatagtc     2760

ctcacctatc cctgttgtat tttatcgggt ccaactcaac catttaaggt atttgccagc     2820

tcttgtatgc atttaggttt tgtttctttg ttttttagct catgaaatta ggtacaaagt     2880

cagagagggg tctggcatat aaaacctcag cagaaataaa gaggttttgt tgtttggtaa     2940

gaacatacct tgggttggtt gggcacggtg gctcgtgcct gtaatcccaa cactttggga     3000

ggccaaggca ggctgatcac ttgaagttgg gagttcaaga ccagcctggc caacatggtg     3060

aaatcccgtc tctactgaaa atacaaaaat taaccaggca tggtggtgtg tgcctgtagt     3120

cccaggaatc acttgaaccc aggaggcgga ggttgcagtg agctgagatc tcaccactgc     3180

acactgcact ccagcctggg caatggaatg agattccatc ccaaaaaata aaaaaataaa     3240

aaaataaaga acataccttg ggttgatcca cttaggaacc tcagataata acatctgcca     3300

cgtatagagc aattgctatg tcccaggcac tctactagac acttcataca gtttagaaaa     3360

tcagatgggt gtagatcaag gcaggagcag gaaccaaaaa gaaaggcata aacataagaa     3420

aaaaaatgga aggggtggaa acagagtaca ataacatgag taatttgatg ggggctatta     3480

tgaactgaga aatgaacttt gaaaagtatc ttggggccaa atcatgtaga ctcttgagtg     3540

atgtgttaag gaatgctatg agtgctgaga gggcatcaga agtccttgag agcctccaga     3600

gaaaggctct taaaaatgca gcgcaatctc cagtgacaga agatactgct agaaatctgc     3660

tagaaaaaaa acaaaaaagg catgtataga ggaattatga gggaaagata ccaagtcacg     3720

gtttattctt caaaatggag gtggcttgtt gggaaggtgg aagctcattt ggccagagtg     3780

gaaatggaat tgggagaaat cgatgaccaa atgtaaacac ttggtgcctg atatagcttg     3840

acaccaagtt agccccaagt gaaataccct ggcaatatta atgtgtcttt tcccgatatt     3900

cctcaggtac tccaaagatt caggtttact cacgtcatcc agcagagaat ggaaagtcaa     3960

atttcctgaa ttgctatgtg tctgggtttc atccatccga cattgaagtt gacttactga     4020

agaatggaga gagaattgaa aaagtggagc attcagactt gtctttcagc aaggactggt     4080

ctttctatct cttgtactac actgaattca cccccactga aaaagatgag tatgcctgcc     4140

gtgtgaacca tgtgactttg tcacagccca agatagttaa gtggggtaag tcttacattc     4200

ttttgtaagc tgctgaaagt tgtgtatgag tagtcatatc ataaagctgc tttgatataa     4260

aaaaggtcta tggccatact accctgaatg agtcccatcc catctgatat aaacaatctg     4320

catattggga ttgtcaggga atgttcttaa agatcagatt agtggcacct gctgagatac     4380

tgatgcacag catggtttct gaaccagtag tttccctgca gttgagcagg gagcagcagc     4440

agcacttgca caaatacata tacactctta acacttctta cctactggct tcctctagct     4500

tttgtggcag cttcaggtat atttagcact gaacgaacat ctcaagaagg tataggcctt     4560

tgtttgtaag tcctgctgtc ctagcatcct ataatcctgg acttctccag tactttctgg     4620

ctggattggt atctgaggct agtaggaagg gcttgttcct gctgggtagc tctaaacaat     4680

gtattcatgg gtaggaacag cagcctattc tgccagcctt atttctaacc attttagaca     4740

tttgttagta catggtattt taaaagtaaa acttaatgtc ttcctttttt ttctccactg     4800

tctttttcat agatcgagac atgtaagcag catcatggag gtaagttttt gaccttgaga     4860

aaatgttttt gtttcactgt cctgaggact atttatagac agctctaaca tgataaccct     4920

cactatgtgg agaacattga cagagtaaca ttttagcagg gaaagaagaa tcctacaggg     4980

tcatgttccc ttctcctgtg gagtggcatg aagaaggtgt atggccccag gtatggccat     5040

attactgacc ctctacagag agggcaaagg aactgccagt atggtattgc aggataaagg     5100

caggtggtta cccacattac ctgcaaggct ttgatctttc ttctgccatt tccacattgg     5160

acatctctgc tgaggagaga aaatgaacca ctcttttcct ttgtataatg ttgttttatt     5220

cttcagacag aagagaggag ttatacagct ctgcagacat cccattcctg tatggggact     5280

gtgtttgcct cttagaggtt cccaggccac tagaggagat aaagggaaac agattgttat     5340

aacttgatat aatgatacta taatagatgt aactacaagg agctccagaa gcaagagaga     5400

gggaggaact tggacttctc tgcatcttta gttggagtcc aaaggctttt caatgaaatt     5460

ctactgccca gggtacattg atgctgaaac cccattcaaa tctcctgtta tattctagaa     5520

cagggaattg atttgggaga gcatcaggaa ggtggatgat ctgcccagtc acactgttag     5580

taaattgtag agccaggacc tgaactctaa tatagtcatg tgttacttaa tgacggggac     5640

atgttctgag aaatgcttac acaaacctag gtgttgtagc ctactacacg cataggctac     5700

atggtatagc ctattgctcc tagactacaa acctgtacag cctgttactg tactgaatac     5760

tgtgggcagt tgtaacacaa tggtaagtat ttgtgtatct aaacatagaa gttgcagtaa     5820

aaatatgcta ttttaatctt atgagaccac tgtcatatat acagtccatc attgaccaaa     5880

acatcatatc agcatttttt cttctaagat tttgggagca ccaaagggat acactaacag     5940

gatatactct ttataatggg tttggagaac tgtctgcagc tacttctttt aaaaaggtga     6000

tctacacagt agaaattaga caagtttggt aatgagatct gcaatccaaa taaaataaat     6060

tcattgctaa cctttttctt ttcttttcag gtttgaagat gccgcatttg gattggatga     6120

attccaaatt ctgcttgctt gctttttaat attgatatgc ttatacactt acactttatg     6180

cacaaaatgt agggttataa taatgttaac atggacatga tcttctttat aattctactt     6240

tgagtgctgt ctccatgttt gatgtatctg agcaggttgc tccacaggta gctctaggag     6300

ggctggcaac ttagaggtgg ggagcagaga attctcttat ccaacatcaa catcttggtc     6360

agatttgaac tcttcaatct cttgcactca aagcttgtta agatagttaa gcgtgcataa     6420

gttaacttcc aatttacata ctctgcttag aatttggggg aaaatttaga aatataattg     6480

acaggattat tggaaatttg ttataatgaa tgaaacattt tgtcatataa gattcatatt     6540

tacttcttat acatttgata aagtaaggca tggttgtggt taatctggtt tatttttgtt     6600

ccacaagtta aataaatcat aaaacttgat gtgttatctc ttatatctca ctcccactat     6660

taccccttta ttttcaaaca gggaaacagt cttcaagttc cacttggtaa aaaatgtgaa     6720

ccccttgtat atagagtttg gctcacagtg taaagggcct cagtgattca cattttccag     6780

attaggaatc tgatgctcaa agaagttaaa tggcatagtt ggggtgacac agctgtctag     6840

tgggaggcca gccttctata ttttagccag cgttctttcc tgcgggccag gtcatgagga     6900

gtatgcagac tctaagaggg agcaaaagta tctgaaggat ttaatatttt agcaaggaat     6960

agatatacaa tcatcccttg gtctccctgg gggattggtt tcaggacccc ttcttggaca     7020

ccaaatctat ggatatttaa gtcccttcta taaaatggta tagtatttgc atataaccta     7080

tccacatcct cctgtatact ttaaatcatt tctagattac ttgtaatacc taatacaatg     7140

taaatgctat gcaaatagtt gttattgttt aaggaataat gacaagaaaa aaaagtctgt     7200

acatgctcag taaagacaca accatccctt tttttcccca gtgtttttga tccatggttt     7260

gctgaatcca cagatgtgga gcccctggat acggaaggcc cgctgtactt tgaatgacaa     7320

ataacagatt taaaattttc aaggcatagt tttatacctg a                         7361


<210> 2
<211> 429
<212> PRT
<213> Homo sapiens

<400> 2
Met Gln Leu Arg Asn Pro Glu Leu His Leu Gly Cys Ala Leu Ala Leu 
1               5                   10                  15      


Arg Phe Leu Ala Leu Val Ser Trp Asp Ile Pro Gly Ala Arg Ala Leu 
            20                  25                  30          


Asp Asn Gly Leu Ala Arg Thr Pro Thr Met Gly Trp Leu His Trp Glu 
        35                  40                  45              


Arg Phe Met Cys Asn Leu Asp Cys Gln Glu Glu Pro Asp Ser Cys Ile 
    50                  55                  60                  


Ser Glu Lys Leu Phe Met Glu Met Ala Glu Leu Met Val Ser Glu Gly 
65                  70                  75                  80  


Trp Lys Asp Ala Gly Tyr Glu Tyr Leu Cys Ile Asp Asp Cys Trp Met 
                85                  90                  95      


Ala Pro Gln Arg Asp Ser Glu Gly Arg Leu Gln Ala Asp Pro Gln Arg 
            100                 105                 110         


Phe Pro His Gly Ile Arg Gln Leu Ala Asn Tyr Val His Ser Lys Gly 
        115                 120                 125             


Leu Lys Leu Gly Ile Tyr Ala Asp Val Gly Asn Lys Thr Cys Ala Gly 
    130                 135                 140                 


Phe Pro Gly Ser Phe Gly Tyr Tyr Asp Ile Asp Ala Gln Thr Phe Ala 
145                 150                 155                 160 


Asp Trp Gly Val Asp Leu Leu Lys Phe Asp Gly Cys Tyr Cys Asp Ser 
                165                 170                 175     


Leu Glu Asn Leu Ala Asp Gly Tyr Lys His Met Ser Leu Ala Leu Asn 
            180                 185                 190         


Arg Thr Gly Arg Ser Ile Val Tyr Ser Cys Glu Trp Pro Leu Tyr Met 
        195                 200                 205             


Trp Pro Phe Gln Lys Pro Asn Tyr Thr Glu Ile Arg Gln Tyr Cys Asn 
    210                 215                 220                 


His Trp Arg Asn Phe Ala Asp Ile Asp Asp Ser Trp Lys Ser Ile Lys 
225                 230                 235                 240 


Ser Ile Leu Asp Trp Thr Ser Phe Asn Gln Glu Arg Ile Val Asp Val 
                245                 250                 255     


Ala Gly Pro Gly Gly Trp Asn Asp Pro Asp Met Leu Val Ile Gly Asn 
            260                 265                 270         


Phe Gly Leu Ser Trp Asn Gln Gln Val Thr Gln Met Ala Leu Trp Ala 
        275                 280                 285             


Ile Met Ala Ala Pro Leu Phe Met Ser Asn Asp Leu Arg His Ile Ser 
    290                 295                 300                 


Pro Gln Ala Lys Ala Leu Leu Gln Asp Lys Asp Val Ile Ala Ile Asn 
305                 310                 315                 320 


Gln Asp Pro Leu Gly Lys Gln Gly Tyr Gln Leu Arg Gln Gly Asp Asn 
                325                 330                 335     


Phe Glu Val Trp Glu Arg Pro Leu Ser Gly Leu Ala Trp Ala Val Ala 
            340                 345                 350         


Met Ile Asn Arg Gln Glu Ile Gly Gly Pro Arg Ser Tyr Thr Ile Ala 
        355                 360                 365             


Val Ala Ser Leu Gly Lys Gly Val Ala Cys Asn Pro Ala Cys Phe Ile 
    370                 375                 380                 


Thr Gln Leu Leu Pro Val Lys Arg Lys Leu Gly Phe Tyr Glu Trp Thr 
385                 390                 395                 400 


Ser Arg Leu Arg Ser His Ile Asn Pro Thr Gly Thr Val Leu Leu Gln 
                405                 410                 415     


Leu Glu Asn Thr Met Gln Met Ser Leu Lys Asp Leu Leu 
            420                 425                 


<210> 3
<211> 452
<212> PRT
<213> Homo sapiens

<400> 3
Met Ser Thr Ala Val Leu Glu Asn Pro Gly Leu Gly Arg Lys Leu Ser 
1               5                   10                  15      


Asp Phe Gly Gln Glu Thr Ser Tyr Ile Glu Asp Asn Cys Asn Gln Asn 
            20                  25                  30          


Gly Ala Ile Ser Leu Ile Phe Ser Leu Lys Glu Glu Val Gly Ala Leu 
        35                  40                  45              


Ala Lys Val Leu Arg Leu Phe Glu Glu Asn Asp Val Asn Leu Thr His 
    50                  55                  60                  


Ile Glu Ser Arg Pro Ser Arg Leu Lys Lys Asp Glu Tyr Glu Phe Phe 
65                  70                  75                  80  


Thr His Leu Asp Lys Arg Ser Leu Pro Ala Leu Thr Asn Ile Ile Lys 
                85                  90                  95      


Ile Leu Arg His Asp Ile Gly Ala Thr Val His Glu Leu Ser Arg Asp 
            100                 105                 110         


Lys Lys Lys Asp Thr Val Pro Trp Phe Pro Arg Thr Ile Gln Glu Leu 
        115                 120                 125             


Asp Arg Phe Ala Asn Gln Ile Leu Ser Tyr Gly Ala Glu Leu Asp Ala 
    130                 135                 140                 


Asp His Pro Gly Phe Lys Asp Pro Val Tyr Arg Ala Arg Arg Lys Gln 
145                 150                 155                 160 


Phe Ala Asp Ile Ala Tyr Asn Tyr Arg His Gly Gln Pro Ile Pro Arg 
                165                 170                 175     


Val Glu Tyr Met Glu Glu Glu Lys Lys Thr Trp Gly Thr Val Phe Lys 
            180                 185                 190         


Thr Leu Lys Ser Leu Tyr Lys Thr His Ala Cys Tyr Glu Tyr Asn His 
        195                 200                 205             


Ile Phe Pro Leu Leu Glu Lys Tyr Cys Gly Phe His Glu Asp Asn Ile 
    210                 215                 220                 


Pro Gln Leu Glu Asp Val Ser Gln Phe Leu Gln Thr Cys Thr Gly Phe 
225                 230                 235                 240 


Arg Leu Arg Pro Val Ala Gly Leu Leu Ser Ser Arg Asp Phe Leu Gly 
                245                 250                 255     


Gly Leu Ala Phe Arg Val Phe His Cys Thr Gln Tyr Ile Arg His Gly 
            260                 265                 270         


Ser Lys Pro Met Tyr Thr Pro Glu Pro Asp Ile Cys His Glu Leu Leu 
        275                 280                 285             


Gly His Val Pro Leu Phe Ser Asp Arg Ser Phe Ala Gln Phe Ser Gln 
    290                 295                 300                 


Glu Ile Gly Leu Ala Ser Leu Gly Ala Pro Asp Glu Tyr Ile Glu Lys 
305                 310                 315                 320 


Leu Ala Thr Ile Tyr Trp Phe Thr Val Glu Phe Gly Leu Cys Lys Gln 
                325                 330                 335     


Gly Asp Ser Ile Lys Ala Tyr Gly Ala Gly Leu Leu Ser Ser Phe Gly 
            340                 345                 350         


Glu Leu Gln Tyr Cys Leu Ser Glu Lys Pro Lys Leu Leu Pro Leu Glu 
        355                 360                 365             


Leu Glu Lys Thr Ala Ile Gln Asn Tyr Thr Val Thr Glu Phe Gln Pro 
    370                 375                 380                 


Leu Tyr Tyr Val Ala Glu Ser Phe Asn Asp Ala Lys Glu Lys Val Arg 
385                 390                 395                 400 


Asn Phe Ala Ala Thr Ile Pro Arg Pro Phe Ser Val Arg Tyr Asp Pro 
                405                 410                 415     


Tyr Thr Gln Arg Ile Glu Val Leu Asp Asn Thr Gln Gln Leu Lys Ile 
            420                 425                 430         


Leu Ala Asp Ser Ile Asn Ser Glu Ile Gly Ile Leu Cys Ser Ala Leu 
        435                 440                 445             


Gln Lys Ile Lys 
    450         


<210> 4
<211> 567
<212> PRT
<213> Anabaena variabilis

<400> 4
Met Lys Thr Leu Ser Gln Ala Gln Ser Lys Thr Ser Ser Gln Gln Phe 
1               5                   10                  15      


Ser Phe Thr Gly Asn Ser Ser Ala Asn Val Ile Ile Gly Asn Gln Lys 
            20                  25                  30          


Leu Thr Ile Asn Asp Val Ala Arg Val Ala Arg Asn Gly Thr Leu Val 
        35                  40                  45              


Ser Leu Thr Asn Asn Thr Asp Ile Leu Gln Gly Ile Gln Ala Ser Cys 
    50                  55                  60                  


Asp Tyr Ile Asn Asn Ala Val Glu Ser Gly Glu Pro Ile Tyr Gly Val 
65                  70                  75                  80  


Thr Ser Gly Phe Gly Gly Met Ala Asn Val Ala Ile Ser Arg Glu Gln 
                85                  90                  95      


Ala Ser Glu Leu Gln Thr Asn Leu Val Trp Phe Leu Lys Thr Gly Ala 
            100                 105                 110         


Gly Asn Lys Leu Pro Leu Ala Asp Val Arg Ala Ala Met Leu Leu Arg 
        115                 120                 125             


Ala Asn Ser His Met Arg Gly Ala Ser Gly Ile Arg Leu Glu Leu Ile 
    130                 135                 140                 


Lys Arg Met Glu Ile Phe Leu Asn Ala Gly Val Thr Pro Tyr Val Tyr 
145                 150                 155                 160 


Glu Phe Gly Ser Ile Gly Ala Ser Gly Asp Leu Val Pro Leu Ser Tyr 
                165                 170                 175     


Ile Thr Gly Ser Leu Ile Gly Leu Asp Pro Ser Phe Lys Val Asp Phe 
            180                 185                 190         


Asn Gly Lys Glu Met Asp Ala Pro Thr Ala Leu Arg Gln Leu Asn Leu 
        195                 200                 205             


Ser Pro Leu Thr Leu Leu Pro Lys Glu Gly Leu Ala Met Met Asn Gly 
    210                 215                 220                 


Thr Ser Val Met Thr Gly Ile Ala Ala Asn Cys Val Tyr Asp Thr Gln 
225                 230                 235                 240 


Ile Leu Thr Ala Ile Ala Met Gly Val His Ala Leu Asp Ile Gln Ala 
                245                 250                 255     


Leu Asn Gly Thr Asn Gln Ser Phe His Pro Phe Ile His Asn Ser Lys 
            260                 265                 270         


Pro His Pro Gly Gln Leu Trp Ala Ala Asp Gln Met Ile Ser Leu Leu 
        275                 280                 285             


Ala Asn Ser Gln Leu Val Arg Asp Glu Leu Asp Gly Lys His Asp Tyr 
    290                 295                 300                 


Arg Asp His Glu Leu Ile Gln Asp Arg Tyr Ser Leu Arg Cys Leu Pro 
305                 310                 315                 320 


Gln Tyr Leu Gly Pro Ile Val Asp Gly Ile Ser Gln Ile Ala Lys Gln 
                325                 330                 335     


Ile Glu Ile Glu Ile Asn Ser Val Thr Asp Asn Pro Leu Ile Asp Val 
            340                 345                 350         


Asp Asn Gln Ala Ser Tyr His Gly Gly Asn Phe Leu Gly Gln Tyr Val 
        355                 360                 365             


Gly Met Gly Met Asp His Leu Arg Tyr Tyr Ile Gly Leu Leu Ala Lys 
    370                 375                 380                 


His Leu Asp Val Gln Ile Ala Leu Leu Ala Ser Pro Glu Phe Ser Asn 
385                 390                 395                 400 


Gly Leu Pro Pro Ser Leu Leu Gly Asn Arg Glu Arg Lys Val Asn Met 
                405                 410                 415     


Gly Leu Lys Gly Leu Gln Ile Cys Gly Asn Ser Ile Met Pro Leu Leu 
            420                 425                 430         


Thr Phe Tyr Gly Asn Ser Ile Ala Asp Arg Phe Pro Thr His Ala Glu 
        435                 440                 445             


Gln Phe Asn Gln Asn Ile Asn Ser Gln Gly Tyr Thr Ser Ala Thr Leu 
    450                 455                 460                 


Ala Arg Arg Ser Val Asp Ile Phe Gln Asn Tyr Val Ala Ile Ala Leu 
465                 470                 475                 480 


Met Phe Gly Val Gln Ala Val Asp Leu Arg Thr Tyr Lys Lys Thr Gly 
                485                 490                 495     


His Tyr Asp Ala Arg Ala Ser Leu Ser Pro Ala Thr Glu Arg Leu Tyr 
            500                 505                 510         


Ser Ala Val Arg His Val Val Gly Gln Lys Pro Thr Ser Asp Arg Pro 
        515                 520                 525             


Tyr Ile Trp Asn Asp Asn Glu Gln Gly Leu Asp Glu His Ile Ala Arg 
    530                 535                 540                 


Ile Ser Ala Asp Ile Ala Ala Gly Gly Val Ile Val Gln Ala Val Gln 
545                 550                 555                 560 


Asp Ile Leu Pro Ser Leu His 
                565         


<210> 5
<211> 952
<212> PRT
<213> Homo sapiens

<400> 5
Met Gly Val Arg His Pro Pro Cys Ser His Arg Leu Leu Ala Val Cys 
1               5                   10                  15      


Ala Leu Val Ser Leu Ala Thr Ala Ala Leu Leu Gly His Ile Leu Leu 
            20                  25                  30          


His Asp Phe Leu Leu Val Pro Arg Glu Leu Ser Gly Ser Ser Pro Val 
        35                  40                  45              


Leu Glu Glu Thr His Pro Ala His Gln Gln Gly Ala Ser Arg Pro Gly 
    50                  55                  60                  


Pro Arg Asp Ala Gln Ala His Pro Gly Arg Pro Arg Ala Val Pro Thr 
65                  70                  75                  80  


Gln Cys Asp Val Pro Pro Asn Ser Arg Phe Asp Cys Ala Pro Asp Lys 
                85                  90                  95      


Ala Ile Thr Gln Glu Gln Cys Glu Ala Arg Gly Cys Cys Tyr Ile Pro 
            100                 105                 110         


Ala Lys Gln Gly Leu Gln Gly Ala Gln Met Gly Gln Pro Trp Cys Phe 
        115                 120                 125             


Phe Pro Pro Ser Tyr Pro Ser Tyr Lys Leu Glu Asn Leu Ser Ser Ser 
    130                 135                 140                 


Glu Met Gly Tyr Thr Ala Thr Leu Thr Arg Thr Thr Pro Thr Phe Phe 
145                 150                 155                 160 


Pro Lys Asp Ile Leu Thr Leu Arg Leu Asp Val Met Met Glu Thr Glu 
                165                 170                 175     


Asn Arg Leu His Phe Thr Ile Lys Asp Pro Ala Asn Arg Arg Tyr Glu 
            180                 185                 190         


Val Pro Leu Glu Thr Pro His Val His Ser Arg Ala Pro Ser Pro Leu 
        195                 200                 205             


Tyr Ser Val Glu Phe Ser Glu Glu Pro Phe Gly Val Ile Val Arg Arg 
    210                 215                 220                 


Gln Leu Asp Gly Arg Val Leu Leu Asn Thr Thr Val Ala Pro Leu Phe 
225                 230                 235                 240 


Phe Ala Asp Gln Phe Leu Gln Leu Ser Thr Ser Leu Pro Ser Gln Tyr 
                245                 250                 255     


Ile Thr Gly Leu Ala Glu His Leu Ser Pro Leu Met Leu Ser Thr Ser 
            260                 265                 270         


Trp Thr Arg Ile Thr Leu Trp Asn Arg Asp Leu Ala Pro Thr Pro Gly 
        275                 280                 285             


Ala Asn Leu Tyr Gly Ser His Pro Phe Tyr Leu Ala Leu Glu Asp Gly 
    290                 295                 300                 


Gly Ser Ala His Gly Val Phe Leu Leu Asn Ser Asn Ala Met Asp Val 
305                 310                 315                 320 


Val Leu Gln Pro Ser Pro Ala Leu Ser Trp Arg Ser Thr Gly Gly Ile 
                325                 330                 335     


Leu Asp Val Tyr Ile Phe Leu Gly Pro Glu Pro Lys Ser Val Val Gln 
            340                 345                 350         


Gln Tyr Leu Asp Val Val Gly Tyr Pro Phe Met Pro Pro Tyr Trp Gly 
        355                 360                 365             


Leu Gly Phe His Leu Cys Arg Trp Gly Tyr Ser Ser Thr Ala Ile Thr 
    370                 375                 380                 


Arg Gln Val Val Glu Asn Met Thr Arg Ala His Phe Pro Leu Asp Val 
385                 390                 395                 400 


Gln Trp Asn Asp Leu Asp Tyr Met Asp Ser Arg Arg Asp Phe Thr Phe 
                405                 410                 415     


Asn Lys Asp Gly Phe Arg Asp Phe Pro Ala Met Val Gln Glu Leu His 
            420                 425                 430         


Gln Gly Gly Arg Arg Tyr Met Met Ile Val Asp Pro Ala Ile Ser Ser 
        435                 440                 445             


Ser Gly Pro Ala Gly Ser Tyr Arg Pro Tyr Asp Glu Gly Leu Arg Arg 
    450                 455                 460                 


Gly Val Phe Ile Thr Asn Glu Thr Gly Gln Pro Leu Ile Gly Lys Val 
465                 470                 475                 480 


Trp Pro Gly Ser Thr Ala Phe Pro Asp Phe Thr Asn Pro Thr Ala Leu 
                485                 490                 495     


Ala Trp Trp Glu Asp Met Val Ala Glu Phe His Asp Gln Val Pro Phe 
            500                 505                 510         


Asp Gly Met Trp Ile Asp Met Asn Glu Pro Ser Asn Phe Ile Arg Gly 
        515                 520                 525             


Ser Glu Asp Gly Cys Pro Asn Asn Glu Leu Glu Asn Pro Pro Tyr Val 
    530                 535                 540                 


Pro Gly Val Val Gly Gly Thr Leu Gln Ala Ala Thr Ile Cys Ala Ser 
545                 550                 555                 560 


Ser His Gln Phe Leu Ser Thr His Tyr Asn Leu His Asn Leu Tyr Gly 
                565                 570                 575     


Leu Thr Glu Ala Ile Ala Ser His Arg Ala Leu Val Lys Ala Arg Gly 
            580                 585                 590         


Thr Arg Pro Phe Val Ile Ser Arg Ser Thr Phe Ala Gly His Gly Arg 
        595                 600                 605             


Tyr Ala Gly His Trp Thr Gly Asp Val Trp Ser Ser Trp Glu Gln Leu 
    610                 615                 620                 


Ala Ser Ser Val Pro Glu Ile Leu Gln Phe Asn Leu Leu Gly Val Pro 
625                 630                 635                 640 


Leu Val Gly Ala Asp Val Cys Gly Phe Leu Gly Asn Thr Ser Glu Glu 
                645                 650                 655     


Leu Cys Val Arg Trp Thr Gln Leu Gly Ala Phe Tyr Pro Phe Met Arg 
            660                 665                 670         


Asn His Asn Ser Leu Leu Ser Leu Pro Gln Glu Pro Tyr Ser Phe Ser 
        675                 680                 685             


Glu Pro Ala Gln Gln Ala Met Arg Lys Ala Leu Thr Leu Arg Tyr Ala 
    690                 695                 700                 


Leu Leu Pro His Leu Tyr Thr Leu Phe His Gln Ala His Val Ala Gly 
705                 710                 715                 720 


Glu Thr Val Ala Arg Pro Leu Phe Leu Glu Phe Pro Lys Asp Ser Ser 
                725                 730                 735     


Thr Trp Thr Val Asp His Gln Leu Leu Trp Gly Glu Ala Leu Leu Ile 
            740                 745                 750         


Thr Pro Val Leu Gln Ala Gly Lys Ala Glu Val Thr Gly Tyr Phe Pro 
        755                 760                 765             


Leu Gly Thr Trp Tyr Asp Leu Gln Thr Val Pro Val Glu Ala Leu Gly 
    770                 775                 780                 


Ser Leu Pro Pro Pro Pro Ala Ala Pro Arg Glu Pro Ala Ile His Ser 
785                 790                 795                 800 


Glu Gly Gln Trp Val Thr Leu Pro Ala Pro Leu Asp Thr Ile Asn Val 
                805                 810                 815     


His Leu Arg Ala Gly Tyr Ile Ile Pro Leu Gln Gly Pro Gly Leu Thr 
            820                 825                 830         


Thr Thr Glu Ser Arg Gln Gln Pro Met Ala Leu Ala Val Ala Leu Thr 
        835                 840                 845             


Lys Gly Gly Glu Ala Arg Gly Glu Leu Phe Trp Asp Asp Gly Glu Ser 
    850                 855                 860                 


Leu Glu Val Leu Glu Arg Gly Ala Tyr Thr Gln Val Ile Phe Leu Ala 
865                 870                 875                 880 


Arg Asn Asn Thr Ile Val Asn Glu Leu Val Arg Val Thr Ser Glu Gly 
                885                 890                 895     


Ala Gly Leu Gln Leu Gln Lys Val Thr Val Leu Gly Val Ala Thr Ala 
            900                 905                 910         


Pro Gln Gln Val Leu Ser Asn Gly Val Pro Val Ser Asn Phe Thr Tyr 
        915                 920                 925             


Ser Pro Asp Thr Lys Val Leu Asp Ile Cys Val Ser Leu Leu Met Gly 
    930                 935                 940                 


Glu Gln Phe Leu Val Ser Trp Cys 
945                 950         


<210> 6
<211> 1457
<212> PRT
<213> Homo sapiens

<400> 6
Met Gln Ile Glu Leu Ser Thr Cys Phe Phe Leu Cys Leu Leu Arg Phe 
1               5                   10                  15      


Cys Phe Ser Ala Thr Arg Arg Tyr Tyr Leu Gly Ala Val Glu Leu Ser 
            20                  25                  30          


Trp Asp Tyr Met Gln Ser Asp Leu Gly Glu Leu Pro Val Asp Ala Arg 
        35                  40                  45              


Phe Pro Pro Arg Val Pro Lys Ser Phe Pro Phe Asn Thr Ser Val Val 
    50                  55                  60                  


Tyr Lys Lys Thr Leu Phe Val Glu Phe Thr Asp His Leu Phe Asn Ile 
65                  70                  75                  80  


Ala Lys Pro Arg Pro Pro Trp Met Gly Leu Leu Gly Pro Thr Ile Gln 
                85                  90                  95      


Ala Glu Val Tyr Asp Thr Val Val Ile Thr Leu Lys Asn Met Ala Ser 
            100                 105                 110         


His Pro Val Ser Leu His Ala Val Gly Val Ser Tyr Trp Lys Ala Ser 
        115                 120                 125             


Glu Gly Ala Glu Tyr Asp Asp Gln Thr Ser Gln Arg Glu Lys Glu Asp 
    130                 135                 140                 


Asp Lys Val Phe Pro Gly Gly Ser His Thr Tyr Val Trp Gln Val Leu 
145                 150                 155                 160 


Lys Glu Asn Gly Pro Met Ala Ser Asp Pro Leu Cys Leu Thr Tyr Ser 
                165                 170                 175     


Tyr Leu Ser His Val Asp Leu Val Lys Asp Leu Asn Ser Gly Leu Ile 
            180                 185                 190         


Gly Ala Leu Leu Val Cys Arg Glu Gly Ser Leu Ala Lys Glu Lys Thr 
        195                 200                 205             


Gln Thr Leu His Lys Phe Ile Leu Leu Phe Ala Val Phe Asp Glu Gly 
    210                 215                 220                 


Lys Ser Trp His Ser Glu Thr Lys Asn Ser Leu Met Gln Asp Arg Asp 
225                 230                 235                 240 


Ala Ala Ser Ala Arg Ala Trp Pro Lys Met His Thr Val Asn Gly Tyr 
                245                 250                 255     


Val Asn Arg Ser Leu Pro Gly Leu Ile Gly Cys His Arg Lys Ser Val 
            260                 265                 270         


Tyr Trp His Val Ile Gly Met Gly Thr Thr Pro Glu Val His Ser Ile 
        275                 280                 285             


Phe Leu Glu Gly His Thr Phe Leu Val Arg Asn His Arg Gln Ala Ser 
    290                 295                 300                 


Leu Glu Ile Ser Pro Ile Thr Phe Leu Thr Ala Gln Thr Leu Leu Met 
305                 310                 315                 320 


Asp Leu Gly Gln Phe Leu Leu Phe Cys His Ile Ser Ser His Gln His 
                325                 330                 335     


Asp Gly Met Glu Ala Tyr Val Lys Val Asp Ser Cys Pro Glu Glu Pro 
            340                 345                 350         


Gln Leu Arg Met Lys Asn Asn Glu Glu Ala Glu Asp Tyr Asp Asp Asp 
        355                 360                 365             


Leu Thr Asp Ser Glu Met Asp Val Val Arg Phe Asp Asp Asp Asn Ser 
    370                 375                 380                 


Pro Ser Phe Ile Gln Ile Arg Ser Val Ala Lys Lys His Pro Lys Thr 
385                 390                 395                 400 


Trp Val His Tyr Ile Ala Ala Glu Glu Glu Asp Trp Asp Tyr Ala Pro 
                405                 410                 415     


Leu Val Leu Ala Pro Asp Asp Arg Ser Tyr Lys Ser Gln Tyr Leu Asn 
            420                 425                 430         


Asn Gly Pro Gln Arg Ile Gly Arg Lys Tyr Lys Lys Val Arg Phe Met 
        435                 440                 445             


Ala Tyr Thr Asp Glu Thr Phe Lys Thr Arg Glu Ala Ile Gln His Glu 
    450                 455                 460                 


Ser Gly Ile Leu Gly Pro Leu Leu Tyr Gly Glu Val Gly Asp Thr Leu 
465                 470                 475                 480 


Leu Ile Ile Phe Lys Asn Gln Ala Ser Arg Pro Tyr Asn Ile Tyr Pro 
                485                 490                 495     


His Gly Ile Thr Asp Val Arg Pro Leu Tyr Ser Arg Arg Leu Pro Lys 
            500                 505                 510         


Gly Val Lys His Leu Lys Asp Phe Pro Ile Leu Pro Gly Glu Ile Phe 
        515                 520                 525             


Lys Tyr Lys Trp Thr Val Thr Val Glu Asp Gly Pro Thr Lys Ser Asp 
    530                 535                 540                 


Pro Arg Cys Leu Thr Arg Tyr Tyr Ser Ser Phe Val Asn Met Glu Arg 
545                 550                 555                 560 


Asp Leu Ala Ser Gly Leu Ile Gly Pro Leu Leu Ile Cys Tyr Lys Glu 
                565                 570                 575     


Ser Val Asp Gln Arg Gly Asn Gln Ile Met Ser Asp Lys Arg Asn Val 
            580                 585                 590         


Ile Leu Phe Ser Val Phe Asp Glu Asn Arg Ser Trp Tyr Leu Thr Glu 
        595                 600                 605             


Asn Ile Gln Arg Phe Leu Pro Asn Pro Ala Gly Val Gln Leu Glu Asp 
    610                 615                 620                 


Pro Glu Phe Gln Ala Ser Asn Ile Met His Ser Ile Asn Gly Tyr Val 
625                 630                 635                 640 


Phe Asp Ser Leu Gln Leu Ser Val Cys Leu His Glu Val Ala Tyr Trp 
                645                 650                 655     


Tyr Ile Leu Ser Ile Gly Ala Gln Thr Asp Phe Leu Ser Val Phe Phe 
            660                 665                 670         


Ser Gly Tyr Thr Phe Lys His Lys Met Val Tyr Glu Asp Thr Leu Thr 
        675                 680                 685             


Leu Phe Pro Phe Ser Gly Glu Thr Val Phe Met Ser Met Glu Asn Pro 
    690                 695                 700                 


Gly Leu Trp Ile Leu Gly Cys His Asn Ser Asp Phe Arg Asn Arg Gly 
705                 710                 715                 720 


Met Thr Ala Leu Leu Lys Val Ser Ser Cys Asp Lys Asn Thr Gly Asp 
                725                 730                 735     


Tyr Tyr Glu Asp Ser Tyr Glu Asp Ile Ser Ala Tyr Leu Leu Ser Lys 
            740                 745                 750         


Asn Asn Ala Ile Glu Pro Arg Ser Phe Ser Gln Asn Pro Pro Val Leu 
        755                 760                 765             


Lys Arg His Gln Arg Glu Ile Thr Arg Thr Thr Leu Gln Ser Asp Gln 
    770                 775                 780                 


Glu Glu Ile Asp Tyr Asp Asp Thr Ile Ser Val Glu Met Lys Lys Glu 
785                 790                 795                 800 


Asp Phe Asp Ile Tyr Asp Glu Asp Glu Asn Gln Ser Pro Arg Ser Phe 
                805                 810                 815     


Gln Lys Lys Thr Arg His Tyr Phe Ile Ala Ala Val Glu Arg Leu Trp 
            820                 825                 830         


Asp Tyr Gly Met Ser Ser Ser Pro His Val Leu Arg Asn Arg Ala Gln 
        835                 840                 845             


Ser Gly Ser Val Pro Gln Phe Lys Lys Val Val Phe Gln Glu Phe Thr 
    850                 855                 860                 


Asp Gly Ser Phe Thr Gln Pro Leu Tyr Arg Gly Glu Leu Asn Glu His 
865                 870                 875                 880 


Leu Gly Leu Leu Gly Pro Tyr Ile Arg Ala Glu Val Glu Asp Asn Ile 
                885                 890                 895     


Met Val Thr Phe Arg Asn Gln Ala Ser Arg Pro Tyr Ser Phe Tyr Ser 
            900                 905                 910         


Ser Leu Ile Ser Tyr Glu Glu Asp Gln Arg Gln Gly Ala Glu Pro Arg 
        915                 920                 925             


Lys Asn Phe Val Lys Pro Asn Glu Thr Lys Thr Tyr Phe Trp Lys Val 
    930                 935                 940                 


Gln His His Met Ala Pro Thr Lys Asp Glu Phe Asp Cys Lys Ala Trp 
945                 950                 955                 960 


Ala Tyr Phe Ser Asp Val Asp Leu Glu Lys Asp Val His Ser Gly Leu 
                965                 970                 975     


Ile Gly Pro Leu Leu Val Cys His Thr Asn Thr Leu Asn Pro Ala His 
            980                 985                 990         


Gly Arg Gln Val Thr Val Gln Glu  Phe Ala Leu Phe Phe  Thr Ile Phe 
        995                 1000                 1005             


Asp Glu  Thr Lys Ser Trp Tyr  Phe Thr Glu Asn Met  Glu Arg Asn 
    1010                 1015                 1020             


Cys Arg  Ala Pro Cys Asn Ile  Gln Met Glu Asp Pro  Thr Phe Lys 
    1025                 1030                 1035             


Glu Asn  Tyr Arg Phe His Ala  Ile Asn Gly Tyr Ile  Met Asp Thr 
    1040                 1045                 1050             


Leu Pro  Gly Leu Val Met Ala  Gln Asp Gln Arg Ile  Arg Trp Tyr 
    1055                 1060                 1065             


Leu Leu  Ser Met Gly Ser Asn  Glu Asn Ile His Ser  Ile His Phe 
    1070                 1075                 1080             


Ser Gly  His Val Phe Thr Val  Arg Lys Lys Glu Glu  Tyr Lys Met 
    1085                 1090                 1095             


Ala Leu  Tyr Asn Leu Tyr Pro  Gly Val Phe Glu Thr  Val Glu Met 
    1100                 1105                 1110             


Leu Pro  Ser Lys Ala Gly Ile  Trp Arg Val Glu Cys  Leu Ile Gly 
    1115                 1120                 1125             


Glu His  Leu His Ala Gly Met  Ser Thr Leu Phe Leu  Val Tyr Ser 
    1130                 1135                 1140             


Asn Lys  Cys Gln Thr Pro Leu  Gly Met Ala Ser Gly  His Ile Arg 
    1145                 1150                 1155             


Asp Phe  Gln Ile Thr Ala Ser  Gly Gln Tyr Gly Gln  Trp Ala Pro 
    1160                 1165                 1170             


Lys Leu  Ala Arg Leu His Tyr  Ser Gly Ser Ile Asn  Ala Trp Ser 
    1175                 1180                 1185             


Thr Lys  Glu Pro Phe Ser Trp  Ile Lys Val Asp Leu  Leu Ala Pro 
    1190                 1195                 1200             


Met Ile  Ile His Gly Ile Lys  Thr Gln Gly Ala Arg  Gln Lys Phe 
    1205                 1210                 1215             


Ser Ser  Leu Tyr Ile Ser Gln  Phe Ile Ile Met Tyr  Ser Leu Asp 
    1220                 1225                 1230             


Gly Lys  Lys Trp Gln Thr Tyr  Arg Gly Asn Ser Thr  Gly Thr Leu 
    1235                 1240                 1245             


Met Val  Phe Phe Gly Asn Val  Asp Ser Ser Gly Ile  Lys His Asn 
    1250                 1255                 1260             


Ile Phe  Asn Pro Pro Ile Ile  Ala Arg Tyr Ile Arg  Leu His Pro 
    1265                 1270                 1275             


Thr His  Tyr Ser Ile Arg Ser  Thr Leu Arg Met Glu  Leu Met Gly 
    1280                 1285                 1290             


Cys Asp  Leu Asn Ser Cys Ser  Met Pro Leu Gly Met  Glu Ser Lys 
    1295                 1300                 1305             


Ala Ile  Ser Asp Ala Gln Ile  Thr Ala Ser Ser Tyr  Phe Thr Asn 
    1310                 1315                 1320             


Met Phe  Ala Thr Trp Ser Pro  Ser Lys Ala Arg Leu  His Leu Gln 
    1325                 1330                 1335             


Gly Arg  Ser Asn Ala Trp Arg  Pro Gln Val Asn Asn  Pro Lys Glu 
    1340                 1345                 1350             


Trp Leu  Gln Val Asp Phe Gln  Lys Thr Val Lys Val  Thr Gly Val 
    1355                 1360                 1365             


Thr Thr  Gln Gly Val Lys Ser  Leu Leu Thr Ser Met  Tyr Val Lys 
    1370                 1375                 1380             


Glu Phe  Leu Ile Ser Ser Ser  Gln Asp Gly His Gln  Trp Thr Leu 
    1385                 1390                 1395             


Phe Phe  Gln Asn Gly Lys Val  Lys Val Phe Gln Gly  Asn Gln Asp 
    1400                 1405                 1410             


Ser Phe  Thr Pro Val Val Asn  Ser Leu Asp Pro Pro  Leu Leu Thr 
    1415                 1420                 1425             


Arg Tyr  Leu Arg Ile His Pro  Gln Ser Trp Val His  Gln Ile Ala 
    1430                 1435                 1440             


Leu Arg  Met Glu Val Leu Gly  Cys Glu Ala Gln Asp  Leu Tyr 
    1445                 1450                 1455         


<210> 7
<211> 2351
<212> PRT
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      polypeptide

<400> 7
Met Gln Ile Glu Leu Ser Thr Cys Phe Phe Leu Cys Leu Leu Arg Phe 
1               5                   10                  15      


Cys Phe Ser Ala Thr Arg Arg Tyr Tyr Leu Gly Ala Val Glu Leu Ser 
            20                  25                  30          


Trp Asp Tyr Met Gln Ser Asp Leu Gly Glu Leu Pro Val Asp Ala Arg 
        35                  40                  45              


Phe Pro Pro Arg Val Pro Lys Ser Phe Pro Phe Asn Thr Ser Val Val 
    50                  55                  60                  


Tyr Lys Lys Thr Leu Phe Val Glu Phe Thr Asp His Leu Phe Asn Ile 
65                  70                  75                  80  


Ala Lys Pro Arg Pro Pro Trp Met Gly Leu Leu Gly Pro Thr Ile Gln 
                85                  90                  95      


Ala Glu Val Tyr Asp Thr Val Val Ile Thr Leu Lys Asn Met Ala Ser 
            100                 105                 110         


His Pro Val Ser Leu His Ala Val Gly Val Ser Tyr Trp Lys Ala Ser 
        115                 120                 125             


Glu Gly Ala Glu Tyr Asp Asp Gln Thr Ser Gln Arg Glu Lys Glu Asp 
    130                 135                 140                 


Asp Lys Val Phe Pro Gly Gly Ser His Thr Tyr Val Trp Gln Val Leu 
145                 150                 155                 160 


Lys Glu Asn Gly Pro Met Ala Ser Asp Pro Leu Cys Leu Thr Tyr Ser 
                165                 170                 175     


Tyr Leu Ser His Val Asp Leu Val Lys Asp Leu Asn Ser Gly Leu Ile 
            180                 185                 190         


Gly Ala Leu Leu Val Cys Arg Glu Gly Ser Leu Ala Lys Glu Lys Thr 
        195                 200                 205             


Gln Thr Leu His Lys Phe Ile Leu Leu Phe Ala Val Phe Asp Glu Gly 
    210                 215                 220                 


Lys Ser Trp His Ser Glu Thr Lys Asn Ser Leu Met Gln Asp Arg Asp 
225                 230                 235                 240 


Ala Ala Ser Ala Arg Ala Trp Pro Lys Met His Thr Val Asn Gly Tyr 
                245                 250                 255     


Val Asn Arg Ser Leu Pro Gly Leu Ile Gly Cys His Arg Lys Ser Val 
            260                 265                 270         


Tyr Trp His Val Ile Gly Met Gly Thr Thr Pro Glu Val His Ser Ile 
        275                 280                 285             


Phe Leu Glu Gly His Thr Phe Leu Val Arg Asn His Arg Gln Ala Ser 
    290                 295                 300                 


Leu Glu Ile Ser Pro Ile Thr Phe Leu Thr Ala Gln Thr Leu Leu Met 
305                 310                 315                 320 


Asp Leu Gly Gln Phe Leu Leu Phe Cys His Ile Ser Ser His Gln His 
                325                 330                 335     


Asp Gly Met Glu Ala Tyr Val Lys Val Asp Ser Cys Pro Glu Glu Pro 
            340                 345                 350         


Gln Leu Arg Met Lys Asn Asn Glu Glu Ala Glu Asp Tyr Asp Asp Asp 
        355                 360                 365             


Leu Thr Asp Ser Glu Met Asp Val Val Arg Phe Asp Asp Asp Asn Ser 
    370                 375                 380                 


Pro Ser Phe Ile Gln Ile Arg Ser Val Ala Lys Lys His Pro Lys Thr 
385                 390                 395                 400 


Trp Val His Tyr Ile Ala Ala Glu Glu Glu Asp Trp Asp Tyr Ala Pro 
                405                 410                 415     


Leu Val Leu Ala Pro Asp Asp Arg Ser Tyr Lys Ser Gln Tyr Leu Asn 
            420                 425                 430         


Asn Gly Pro Gln Arg Ile Gly Arg Lys Tyr Lys Lys Val Arg Phe Met 
        435                 440                 445             


Ala Tyr Thr Asp Glu Thr Phe Lys Thr Arg Glu Ala Ile Gln His Glu 
    450                 455                 460                 


Ser Gly Ile Leu Gly Pro Leu Leu Tyr Gly Glu Val Gly Asp Thr Leu 
465                 470                 475                 480 


Leu Ile Ile Phe Lys Asn Gln Ala Ser Arg Pro Tyr Asn Ile Tyr Pro 
                485                 490                 495     


His Gly Ile Thr Asp Val Arg Pro Leu Tyr Ser Arg Arg Leu Pro Lys 
            500                 505                 510         


Gly Val Lys His Leu Lys Asp Phe Pro Ile Leu Pro Gly Glu Ile Phe 
        515                 520                 525             


Lys Tyr Lys Trp Thr Val Thr Val Glu Asp Gly Pro Thr Lys Ser Asp 
    530                 535                 540                 


Pro Arg Cys Leu Thr Arg Tyr Tyr Ser Ser Phe Val Asn Met Glu Arg 
545                 550                 555                 560 


Asp Leu Ala Ser Gly Leu Ile Gly Pro Leu Leu Ile Cys Tyr Lys Glu 
                565                 570                 575     


Ser Val Asp Gln Arg Gly Asn Gln Ile Met Ser Asp Lys Arg Asn Val 
            580                 585                 590         


Ile Leu Phe Ser Val Phe Asp Glu Asn Arg Ser Trp Tyr Leu Thr Glu 
        595                 600                 605             


Asn Ile Gln Arg Phe Leu Pro Asn Pro Ala Gly Val Gln Leu Glu Asp 
    610                 615                 620                 


Pro Glu Phe Gln Ala Ser Asn Ile Met His Ser Ile Asn Gly Tyr Val 
625                 630                 635                 640 


Phe Asp Ser Leu Gln Leu Ser Val Cys Leu His Glu Val Ala Tyr Trp 
                645                 650                 655     


Tyr Ile Leu Ser Ile Gly Ala Gln Thr Asp Phe Leu Ser Val Phe Phe 
            660                 665                 670         


Ser Gly Tyr Thr Phe Lys His Lys Met Val Tyr Glu Asp Thr Leu Thr 
        675                 680                 685             


Leu Phe Pro Phe Ser Gly Glu Thr Val Phe Met Ser Met Glu Asn Pro 
    690                 695                 700                 


Gly Leu Trp Ile Leu Gly Cys His Asn Ser Asp Phe Arg Asn Arg Gly 
705                 710                 715                 720 


Met Thr Ala Leu Leu Lys Val Ser Ser Cys Asp Lys Asn Thr Gly Asp 
                725                 730                 735     


Tyr Tyr Glu Asp Ser Tyr Glu Asp Ile Ser Ala Tyr Leu Leu Ser Lys 
            740                 745                 750         


Asn Asn Ala Ile Glu Pro Arg Ser Phe Ser Gln Asn Ser Arg His Pro 
        755                 760                 765             


Ser Thr Arg Gln Lys Gln Phe Asn Ala Thr Thr Ile Pro Glu Asn Asp 
    770                 775                 780                 


Ile Glu Lys Thr Asp Pro Trp Phe Ala His Arg Thr Pro Met Pro Lys 
785                 790                 795                 800 


Ile Gln Asn Val Ser Ser Ser Asp Leu Leu Met Leu Leu Arg Gln Ser 
                805                 810                 815     


Pro Thr Pro His Gly Leu Ser Leu Ser Asp Leu Gln Glu Ala Lys Tyr 
            820                 825                 830         


Glu Thr Phe Ser Asp Asp Pro Ser Pro Gly Ala Ile Asp Ser Asn Asn 
        835                 840                 845             


Ser Leu Ser Glu Met Thr His Phe Arg Pro Gln Leu His His Ser Gly 
    850                 855                 860                 


Asp Met Val Phe Thr Pro Glu Ser Gly Leu Gln Leu Arg Leu Asn Glu 
865                 870                 875                 880 


Lys Leu Gly Thr Thr Ala Ala Thr Glu Leu Lys Lys Leu Asp Phe Lys 
                885                 890                 895     


Val Ser Ser Thr Ser Asn Asn Leu Ile Ser Thr Ile Pro Ser Asp Asn 
            900                 905                 910         


Leu Ala Ala Gly Thr Asp Asn Thr Ser Ser Leu Gly Pro Pro Ser Met 
        915                 920                 925             


Pro Val His Tyr Asp Ser Gln Leu Asp Thr Thr Leu Phe Gly Lys Lys 
    930                 935                 940                 


Ser Ser Pro Leu Thr Glu Ser Gly Gly Pro Leu Ser Leu Ser Glu Glu 
945                 950                 955                 960 


Asn Asn Asp Ser Lys Leu Leu Glu Ser Gly Leu Met Asn Ser Gln Glu 
                965                 970                 975     


Ser Ser Trp Gly Lys Asn Val Ser Ser Thr Glu Ser Gly Arg Leu Phe 
            980                 985                 990         


Lys Gly Lys Arg Ala His Gly Pro  Ala Leu Leu Thr Lys  Asp Asn Ala 
        995                 1000                 1005             


Leu Phe  Lys Val Ser Ile Ser  Leu Leu Lys Thr Asn  Lys Thr Ser 
    1010                 1015                 1020             


Asn Asn  Ser Ala Thr Asn Arg  Lys Thr His Ile Asp  Gly Pro Ser 
    1025                 1030                 1035             


Leu Leu  Ile Glu Asn Ser Pro  Ser Val Trp Gln Asn  Ile Leu Glu 
    1040                 1045                 1050             


Ser Asp  Thr Glu Phe Lys Lys  Val Thr Pro Leu Ile  His Asp Arg 
    1055                 1060                 1065             


Met Leu  Met Asp Lys Asn Ala  Thr Ala Leu Arg Leu  Asn His Met 
    1070                 1075                 1080             


Ser Asn  Lys Thr Thr Ser Ser  Lys Asn Met Glu Met  Val Gln Gln 
    1085                 1090                 1095             


Lys Lys  Glu Gly Pro Ile Pro  Pro Asp Ala Gln Asn  Pro Asp Met 
    1100                 1105                 1110             


Ser Phe  Phe Lys Met Leu Phe  Leu Pro Glu Ser Ala  Arg Trp Ile 
    1115                 1120                 1125             


Gln Arg  Thr His Gly Lys Asn  Ser Leu Asn Ser Gly  Gln Gly Pro 
    1130                 1135                 1140             


Ser Pro  Lys Gln Leu Val Ser  Leu Gly Pro Glu Lys  Ser Val Glu 
    1145                 1150                 1155             


Gly Gln  Asn Phe Leu Ser Glu  Lys Asn Lys Val Val  Val Gly Lys 
    1160                 1165                 1170             


Gly Glu  Phe Thr Lys Asp Val  Gly Leu Lys Glu Met  Val Phe Pro 
    1175                 1180                 1185             


Ser Ser  Arg Asn Leu Phe Leu  Thr Asn Leu Asp Asn  Leu His Glu 
    1190                 1195                 1200             


Asn Asn  Thr His Asn Gln Glu  Lys Lys Ile Gln Glu  Glu Ile Glu 
    1205                 1210                 1215             


Lys Lys  Glu Thr Leu Ile Gln  Glu Asn Val Val Leu  Pro Gln Ile 
    1220                 1225                 1230             


His Thr  Val Thr Gly Thr Lys  Asn Phe Met Lys Asn  Leu Phe Leu 
    1235                 1240                 1245             


Leu Ser  Thr Arg Gln Asn Val  Glu Gly Ser Tyr Asp  Gly Ala Tyr 
    1250                 1255                 1260             


Ala Pro  Val Leu Gln Asp Phe  Arg Ser Leu Asn Asp  Ser Thr Asn 
    1265                 1270                 1275             


Arg Thr  Lys Lys His Thr Ala  His Phe Ser Lys Lys  Gly Glu Glu 
    1280                 1285                 1290             


Glu Asn  Leu Glu Gly Leu Gly  Asn Gln Thr Lys Gln  Ile Val Glu 
    1295                 1300                 1305             


Lys Tyr  Ala Cys Thr Thr Arg  Ile Ser Pro Asn Thr  Ser Gln Gln 
    1310                 1315                 1320             


Asn Phe  Val Thr Gln Arg Ser  Lys Arg Ala Leu Lys  Gln Phe Arg 
    1325                 1330                 1335             


Leu Pro  Leu Glu Glu Thr Glu  Leu Glu Lys Arg Ile  Ile Val Asp 
    1340                 1345                 1350             


Asp Thr  Ser Thr Gln Trp Ser  Lys Asn Met Lys His  Leu Thr Pro 
    1355                 1360                 1365             


Ser Thr  Leu Thr Gln Ile Asp  Tyr Asn Glu Lys Glu  Lys Gly Ala 
    1370                 1375                 1380             


Ile Thr  Gln Ser Pro Leu Ser  Asp Cys Leu Thr Arg  Ser His Ser 
    1385                 1390                 1395             


Ile Pro  Gln Ala Asn Arg Ser  Pro Leu Pro Ile Ala  Lys Val Ser 
    1400                 1405                 1410             


Ser Phe  Pro Ser Ile Arg Pro  Ile Tyr Leu Thr Arg  Val Leu Phe 
    1415                 1420                 1425             


Gln Asp  Asn Ser Ser His Leu  Pro Ala Ala Ser Tyr  Arg Lys Lys 
    1430                 1435                 1440             


Asp Ser  Gly Val Gln Glu Ser  Ser His Phe Leu Gln  Gly Ala Lys 
    1445                 1450                 1455             


Lys Asn  Asn Leu Ser Leu Ala  Ile Leu Thr Leu Glu  Met Thr Gly 
    1460                 1465                 1470             


Asp Gln  Arg Glu Val Gly Ser  Leu Gly Thr Ser Ala  Thr Asn Ser 
    1475                 1480                 1485             


Val Thr  Tyr Lys Lys Val Glu  Asn Thr Val Leu Pro  Lys Pro Asp 
    1490                 1495                 1500             


Leu Pro  Lys Thr Ser Gly Lys  Val Glu Leu Leu Pro  Lys Val His 
    1505                 1510                 1515             


Ile Tyr  Gln Lys Asp Leu Phe  Pro Thr Glu Thr Ser  Asn Gly Ser 
    1520                 1525                 1530             


Pro Gly  His Leu Asp Leu Val  Glu Gly Ser Leu Leu  Gln Gly Thr 
    1535                 1540                 1545             


Glu Gly  Ala Ile Lys Trp Asn  Glu Ala Asn Arg Pro  Gly Lys Val 
    1550                 1555                 1560             


Pro Phe  Leu Arg Val Ala Thr  Glu Ser Ser Ala Lys  Thr Pro Ser 
    1565                 1570                 1575             


Lys Leu  Leu Asp Pro Leu Ala  Trp Asp Asn His Tyr  Gly Thr Gln 
    1580                 1585                 1590             


Ile Pro  Lys Glu Glu Trp Lys  Ser Gln Glu Lys Ser  Pro Glu Lys 
    1595                 1600                 1605             


Thr Ala  Phe Lys Lys Lys Asp  Thr Ile Leu Ser Leu  Asn Ala Cys 
    1610                 1615                 1620             


Glu Ser  Asn His Ala Ile Ala  Ala Ile Asn Glu Gly  Gln Asn Lys 
    1625                 1630                 1635             


Pro Glu  Ile Glu Val Thr Trp  Ala Lys Gln Gly Arg  Thr Glu Arg 
    1640                 1645                 1650             


Leu Cys  Ser Gln Asn Pro Pro  Val Leu Lys Arg His  Gln Arg Glu 
    1655                 1660                 1665             


Ile Thr  Arg Thr Thr Leu Gln  Ser Asp Gln Glu Glu  Ile Asp Tyr 
    1670                 1675                 1680             


Asp Asp  Thr Ile Ser Val Glu  Met Lys Lys Glu Asp  Phe Asp Ile 
    1685                 1690                 1695             


Tyr Asp  Glu Asp Glu Asn Gln  Ser Pro Arg Ser Phe  Gln Lys Lys 
    1700                 1705                 1710             


Thr Arg  His Tyr Phe Ile Ala  Ala Val Glu Arg Leu  Trp Asp Tyr 
    1715                 1720                 1725             


Gly Met  Ser Ser Ser Pro His  Val Leu Arg Asn Arg  Ala Gln Ser 
    1730                 1735                 1740             


Gly Ser  Val Pro Gln Phe Lys  Lys Val Val Phe Gln  Glu Phe Thr 
    1745                 1750                 1755             


Asp Gly  Ser Phe Thr Gln Pro  Leu Tyr Arg Gly Glu  Leu Asn Glu 
    1760                 1765                 1770             


His Leu  Gly Leu Leu Gly Pro  Tyr Ile Arg Ala Glu  Val Glu Asp 
    1775                 1780                 1785             


Asn Ile  Met Val Thr Phe Arg  Asn Gln Ala Ser Arg  Pro Tyr Ser 
    1790                 1795                 1800             


Phe Tyr  Ser Ser Leu Ile Ser  Tyr Glu Glu Asp Gln  Arg Gln Gly 
    1805                 1810                 1815             


Ala Glu  Pro Arg Lys Asn Phe  Val Lys Pro Asn Glu  Thr Lys Thr 
    1820                 1825                 1830             


Tyr Phe  Trp Lys Val Gln His  His Met Ala Pro Thr  Lys Asp Glu 
    1835                 1840                 1845             


Phe Asp  Cys Lys Ala Trp Ala  Tyr Phe Ser Asp Val  Asp Leu Glu 
    1850                 1855                 1860             


Lys Asp  Val His Ser Gly Leu  Ile Gly Pro Leu Leu  Val Cys His 
    1865                 1870                 1875             


Thr Asn  Thr Leu Asn Pro Ala  His Gly Arg Gln Val  Thr Val Gln 
    1880                 1885                 1890             


Glu Phe  Ala Leu Phe Phe Thr  Ile Phe Asp Glu Thr  Lys Ser Trp 
    1895                 1900                 1905             


Tyr Phe  Thr Glu Asn Met Glu  Arg Asn Cys Arg Ala  Pro Cys Asn 
    1910                 1915                 1920             


Ile Gln  Met Glu Asp Pro Thr  Phe Lys Glu Asn Tyr  Arg Phe His 
    1925                 1930                 1935             


Ala Ile  Asn Gly Tyr Ile Met  Asp Thr Leu Pro Gly  Leu Val Met 
    1940                 1945                 1950             


Ala Gln  Asp Gln Arg Ile Arg  Trp Tyr Leu Leu Ser  Met Gly Ser 
    1955                 1960                 1965             


Asn Glu  Asn Ile His Ser Ile  His Phe Ser Gly His  Val Phe Thr 
    1970                 1975                 1980             


Val Arg  Lys Lys Glu Glu Tyr  Lys Met Ala Leu Tyr  Asn Leu Tyr 
    1985                 1990                 1995             


Pro Gly  Val Phe Glu Thr Val  Glu Met Leu Pro Ser  Lys Ala Gly 
    2000                 2005                 2010             


Ile Trp  Arg Val Glu Cys Leu  Ile Gly Glu His Leu  His Ala Gly 
    2015                 2020                 2025             


Met Ser  Thr Leu Phe Leu Val  Tyr Ser Asn Lys Cys  Gln Thr Pro 
    2030                 2035                 2040             


Leu Gly  Met Ala Ser Gly His  Ile Arg Asp Phe Gln  Ile Thr Ala 
    2045                 2050                 2055             


Ser Gly  Gln Tyr Gly Gln Trp  Ala Pro Lys Leu Ala  Arg Leu His 
    2060                 2065                 2070             


Tyr Ser  Gly Ser Ile Asn Ala  Trp Ser Thr Lys Glu  Pro Phe Ser 
    2075                 2080                 2085             


Trp Ile  Lys Val Asp Leu Leu  Ala Pro Met Ile Ile  His Gly Ile 
    2090                 2095                 2100             


Lys Thr  Gln Gly Ala Arg Gln  Lys Phe Ser Ser Leu  Tyr Ile Ser 
    2105                 2110                 2115             


Gln Phe  Ile Ile Met Tyr Ser  Leu Asp Gly Lys Lys  Trp Gln Thr 
    2120                 2125                 2130             


Tyr Arg  Gly Asn Ser Thr Gly  Thr Leu Met Val Phe  Phe Gly Asn 
    2135                 2140                 2145             


Val Asp  Ser Ser Gly Ile Lys  His Asn Ile Phe Asn  Pro Pro Ile 
    2150                 2155                 2160             


Ile Ala  Arg Tyr Ile Arg Leu  His Pro Thr His Tyr  Ser Ile Arg 
    2165                 2170                 2175             


Ser Thr  Leu Arg Met Glu Leu  Met Gly Cys Asp Leu  Asn Ser Cys 
    2180                 2185                 2190             


Ser Met  Pro Leu Gly Met Glu  Ser Lys Ala Ile Ser  Asp Ala Gln 
    2195                 2200                 2205             


Ile Thr  Ala Ser Ser Tyr Phe  Thr Asn Met Phe Ala  Thr Trp Ser 
    2210                 2215                 2220             


Pro Ser  Lys Ala Arg Leu His  Leu Gln Gly Arg Ser  Asn Ala Trp 
    2225                 2230                 2235             


Arg Pro  Gln Val Asn Asn Pro  Lys Glu Trp Leu Gln  Val Asp Phe 
    2240                 2245                 2250             


Gln Lys  Thr Met Lys Val Thr  Gly Val Thr Thr Gln  Gly Val Lys 
    2255                 2260                 2265             


Ser Leu  Leu Thr Ser Met Tyr  Val Lys Glu Phe Leu  Ile Ser Ser 
    2270                 2275                 2280             


Ser Gln  Asp Gly His Gln Trp  Thr Leu Phe Phe Gln  Asn Gly Lys 
    2285                 2290                 2295             


Val Lys  Val Phe Gln Gly Asn  Gln Asp Ser Phe Thr  Pro Val Val 
    2300                 2305                 2310             


Asn Ser  Leu Asp Pro Pro Leu  Leu Thr Arg Tyr Leu  Arg Ile His 
    2315                 2320                 2325             


Pro Gln  Ser Trp Val His Gln  Ile Ala Leu Arg Met  Glu Val Leu 
    2330                 2335                 2340             


Gly Cys  Glu Ala Gln Asp Leu  Tyr 
    2345                 2350     


<210> 8
<211> 416
<212> PRT
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      polypeptide

<400> 8
Met Glu Thr Asp Thr Leu Leu Leu Trp Val Leu Leu Leu Trp Val Pro 
1               5                   10                  15      


Gly Ser Thr Gly Gln Ser Val Leu Thr Gln Pro Pro Ser Val Ser Ala 
            20                  25                  30          


Ala Pro Gly Gln Arg Val Thr Ile Ser Cys Ser Gly Thr Arg Ser Asn 
        35                  40                  45              


Ile Gly Ser Asp Tyr Val Ser Trp Tyr Gln His Leu Pro Gly Thr Ala 
    50                  55                  60                  


Pro Lys Leu Leu Val Tyr Gly Asp Asn Leu Arg Pro Ser Gly Ile Pro 
65                  70                  75                  80  


Asp Arg Phe Ser Ala Ser Lys Ser Gly Thr Ser Ala Thr Leu Gly Ile 
                85                  90                  95      


Thr Gly Leu Gln Thr Gly Asp Glu Ala Asp Tyr Tyr Cys Gly Thr Trp 
            100                 105                 110         


Asp Tyr Thr Leu Asn Gly Val Val Phe Gly Gly Gly Thr Lys Leu Thr 
        115                 120                 125             


Val Leu Gly Ser Arg Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser Gly 
    130                 135                 140                 


Gly Gly Gly Ser Leu Glu Met Ala Gln Val Gln Leu Val Glu Ser Gly 
145                 150                 155                 160 


Gly Gly Leu Val Gln Pro Gly Gly Ser Leu Arg Leu Ser Cys Ala Ala 
                165                 170                 175     


Ser Gly Phe Thr Phe Ser Ser Tyr Ala Met Ser Trp Val Arg Gln Ala 
            180                 185                 190         


Pro Gly Lys Gly Leu Glu Trp Val Ser Val Ile Tyr Ser Gly Gly Ser 
        195                 200                 205             


Ser Thr Tyr Tyr Ala Asp Ser Val Lys Gly Arg Phe Thr Ile Ser Arg 
    210                 215                 220                 


Asp Asn Ser Lys Asn Thr Leu Tyr Leu Gln Met Asn Ser Leu Arg Ala 
225                 230                 235                 240 


Glu Asp Thr Ala Val Tyr Tyr Cys Ala Arg Thr Ser Tyr Leu Asn His 
                245                 250                 255     


Gly Asp Tyr Trp Gly Gln Gly Thr Leu Val Thr Val Ser Ser Ala Ala 
            260                 265                 270         


Ala Phe Val Pro Val Phe Leu Pro Ala Lys Pro Thr Thr Thr Pro Ala 
        275                 280                 285             


Pro Arg Pro Pro Thr Pro Ala Pro Thr Ile Ala Ser Gln Pro Leu Ser 
    290                 295                 300                 


Leu Arg Pro Glu Ala Cys Arg Pro Ala Ala Gly Gly Ala Val His Thr 
305                 310                 315                 320 


Arg Gly Leu Asp Phe Ala Cys Asp Phe Trp Val Leu Val Val Val Gly 
                325                 330                 335     


Gly Val Leu Ala Cys Tyr Ser Leu Leu Val Thr Val Ala Phe Ile Ile 
            340                 345                 350         


Phe Trp Val Arg Lys Arg Trp Gln Asn Glu Lys Leu Gly Leu Asp Ala 
        355                 360                 365             


Gly Asp Glu Tyr Glu Asp Glu Asn Leu Tyr Glu Gly Leu Asn Leu Asp 
    370                 375                 380                 


Asp Cys Ser Met Tyr Glu Asp Ile Ser Arg Gly Leu Gln Gly Thr Tyr 
385                 390                 395                 400 


Gln Asp Val Gly Ser Leu Asn Ile Gly Asp Val Gln Leu Glu Lys Pro 
                405                 410                 415     


<210> 9
<211> 178
<212> PRT
<213> Homo sapiens

<400> 9
Met His Ser Ser Ala Leu Leu Cys Cys Leu Val Leu Leu Thr Gly Val 
1               5                   10                  15      


Arg Ala Ser Pro Gly Gln Gly Thr Gln Ser Glu Asn Ser Cys Thr His 
            20                  25                  30          


Phe Pro Gly Asn Leu Pro Asn Met Leu Arg Asp Leu Arg Asp Ala Phe 
        35                  40                  45              


Ser Arg Val Lys Thr Phe Phe Gln Met Lys Asp Gln Leu Asp Asn Leu 
    50                  55                  60                  


Leu Leu Lys Glu Ser Leu Leu Glu Asp Phe Lys Gly Tyr Leu Gly Cys 
65                  70                  75                  80  


Gln Ala Leu Ser Glu Met Ile Gln Phe Tyr Leu Glu Glu Val Met Pro 
                85                  90                  95      


Gln Ala Glu Asn Gln Asp Pro Asp Ile Lys Ala His Val Asn Ser Leu 
            100                 105                 110         


Gly Glu Asn Leu Lys Thr Leu Arg Leu Arg Leu Arg Arg Cys His Arg 
        115                 120                 125             


Phe Leu Pro Cys Glu Asn Lys Ser Lys Ala Val Glu Gln Val Lys Asn 
    130                 135                 140                 


Ala Phe Asn Lys Leu Gln Glu Lys Gly Ile Tyr Lys Ala Met Ser Glu 
145                 150                 155                 160 


Phe Asp Ile Phe Ile Asn Tyr Ile Glu Ala Tyr Met Thr Met Lys Ile 
                165                 170                 175     


Arg Asn 
        


<210> 10
<211> 2652
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      polynucleotide

<400> 10
gctatgtccc aggcactcta ctagacactt catacagttt agaaaatcag atgggtgtag       60

atcaaggcag gagcaggaac caaaaagaaa ggcataaaca taagaaaaaa aatggaaggg      120

gtggaaacag agtacaataa catgagtaat ttgatggggg ctattatgaa ctgagaaatg      180

aactttgaaa agtatcttgg ggccaaatca tgtagactct tgagtgatgt gttaaggaat      240

gctatgagtg ctgagagggc atcagaagtc cttgagagcc tccagagaaa ggctcttaaa      300

aatgcagcgc aatctccagt gacagaagat actgctagaa atctgctaga aaaaaaacaa      360

aaaaggcatg tatagaggaa ttatgaggga aagataccaa gtcacggttt attcttcaaa      420

atggaggtgg cttgttggga aggtggaagc tcatttggcc agagtggaaa tggaattggg      480

agaaatcgat gaccaaatgt aaacacttgg tgcctgatat agcttgacac caagttagcc      540

ccaagtgaaa taccctggca atattaatgt gtcttttccc gatattcctc aggtactccc      600

tgcagggagg gcagaggaag tcttctaaca tgcggtgacg tggaggagaa tcccggccct      660

actagtgcca ccatgcagct gagaaaccca gagttgcatc tgggatgcgc cctggcactt      720

cgatttctcg ccctcgtatc ttgggacatc cctggcgcgc gcgcactgga caacggactg      780

gctaggaccc ccaccatggg ttggttacac tgggaacggt ttatgtgtaa tctcgactgt      840

caggaagaac cggactcttg tatctcagaa aaattgttta tggagatggc agaactgatg      900

gtgtcagagg ggtggaaaga tgctgggtac gaatacctct gcatagatga ctgttggatg      960

gcgccccagc gtgacagcga gggacgcctg caggctgatc ctcagagatt cccacatggg     1020

attcgacagc tcgctaatta cgtgcactca aaaggcctga aactggggat ctatgccgac     1080

gtcgggaaca aaacctgtgc aggattccct ggaagtttcg ggtactacga catcgacgcc     1140

caaacctttg cagactgggg cgttgatctg ctgaagtttg acggatgtta ttgtgacagc     1200

ctggagaacc ttgccgacgg ctataagcat atgagcttgg cattgaaccg caccggacga     1260

agcatagtgt actcttgcga gtggcctctc tatatgtggc cttttcagaa accaaactac     1320

acggaaatac ggcaatactg caatcattgg aggaacttcg ccgatattga cgattcttgg     1380

aaatccatca aaagcatatt agactggacc agtttcaatc aggaaagaat cgtggacgtt     1440

gctggtccag gaggttggaa cgatccagac atgctggtga ttgggaactt cggcctcagt     1500

tggaatcagc aggtcacaca aatggcgctg tgggctatca tggctgcacc gctgtttatg     1560

tcaaacgacc tgcgacacat cagccctcag gctaaggcat tgttgcaaga taaggatgta     1620

atagcaataa accaggaccc cctcggtaag cagggctatc agttacgcca gggcgataac     1680

tttgaagtgt gggaacgacc gttgtccggc ctggcctggg ctgtggccat gataaaccga     1740

caagagattg gagggcccag gtcttatact atcgctgtgg caagtcttgg aaaaggagtg     1800

gcttgcaacc cagcatgctt cattactcag ttgctcccag tcaaaagaaa gctcggcttt     1860

tacgagtgga ctagtcgact tcggagtcat attaatccaa ccggcaccgt cttacttcag     1920

ctggagaata caatgcagat gtccctgaag gacctcctct agaggctagg tggaggctca     1980

gtgaaactta ctcacgtcat ccagcagaga atggaaagtc aaatttcctg aattgctatg     2040

tgtctgggtt tcatccatcc gacattgaag ttgacttact gaagaatgga gagagaattg     2100

aaaaagtgga gcattcagac ttgtctttca gcaaggactg gtctttctat ctcttgtact     2160

acactgaatt cacccccact gaaaaagatg agtatgcctg ccgtgtgaac catgtgactt     2220

tgtcacagcc caagatagtt aagtggggta agtcttacat tcttttgtaa gctgctgaaa     2280

gttgtgtatg agtagtcata tcataaagct gctttgatat aaaaaaggtc tatggccata     2340

ctaccctgaa tgagtcccat cccatctgat ataaacaatc tgcatattgg gattgtcagg     2400

gaatgttctt aaagatcaga ttagtggcac ctgctgagat actgatgcac agcatggttt     2460

ctgaaccagt agtttccctg cagttgagca gggagcagca gcagcacttg cacaaataca     2520

tatacactct taacacttct tacctactgg cttcctctag cttttgtggc agcttcaggt     2580

atatttagca ctgaacgaac atctcaagaa ggtataggcc tttgtttgta agtcctgctg     2640

tcctagcatc ct                                                         2652


<210> 11
<211> 2721
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      polynucleotide

<400> 11
gctatgtccc aggcactcta ctagacactt catacagttt agaaaatcag atgggtgtag       60

atcaaggcag gagcaggaac caaaaagaaa ggcataaaca taagaaaaaa aatggaaggg      120

gtggaaacag agtacaataa catgagtaat ttgatggggg ctattatgaa ctgagaaatg      180

aactttgaaa agtatcttgg ggccaaatca tgtagactct tgagtgatgt gttaaggaat      240

gctatgagtg ctgagagggc atcagaagtc cttgagagcc tccagagaaa ggctcttaaa      300

aatgcagcgc aatctccagt gacagaagat actgctagaa atctgctaga aaaaaaacaa      360

aaaaggcatg tatagaggaa ttatgaggga aagataccaa gtcacggttt attcttcaaa      420

atggaggtgg cttgttggga aggtggaagc tcatttggcc agagtggaaa tggaattggg      480

agaaatcgat gaccaaatgt aaacacttgg tgcctgatat agcttgacac caagttagcc      540

ccaagtgaaa taccctggca atattaatgt gtcttttccc gatattcctc aggtactccc      600

tgcagggagg gcagaggaag tcttctaaca tgcggtgacg tggaggagaa tcccggccct      660

actagtgcca ccatgtctac cgctgtgttg gagaacccag ggctcgggcg taaactgtca      720

gacttcggcc aggaaacttc ttatatagaa gacaactgta accagaatgg tgcaatctct      780

ctcattttca gtcttaagga ggaggtcggc gccttggcta aggttttacg tctgttcgag      840

gagaatgatg tgaacctgac acatatcgag tccaggccat cccgcttgaa gaaagatgag      900

tatgaattct ttacacatct cgacaaacgg agtctccctg ctctgacaaa tataattaaa      960

attctgaggc atgacatcgg agccacagtg catgaactga gccgtgataa aaagaaggat     1020

accgtcccat ggtttcctcg gacgattcag gaacttgacc gattcgctaa ccagatattg     1080

tcctacggtg ctgagctgga cgcggatcat cccggattca aggaccctgt atacagagct     1140

cgccggaagc agttcgcaga cattgcctat aattatagac acggtcagcc gattcctaga     1200

gtcgaatata tggaggagga aaagaaaacg tgggggacag tgtttaaaac attaaagagt     1260

ctctacaaga cacatgcttg ttatgagtat aatcacatct tccccctgtt ggagaaatac     1320

tgcgggtttc acgaggataa cataccccag ctggaagacg ttagtcagtt ccttcagact     1380

tgcaccgggt ttaggctgcg cccagttgcc ggcctcctca gttcacggga ttttctcggc     1440

ggcctggctt tccgcgtgtt ccattgtaca cagtacattc gacatggatc taaaccaatg     1500

tatactcccg aaccagatat ttgccatgag ctccttgggc acgtgccact tttctctgac     1560

aggagtttcg ctcaatttag ccaggagatt ggactcgcca gcctgggtgc ccctgacgaa     1620

tacattgaaa aactcgcaac catttactgg ttcaccgtgg agtttggact ctgtaaacaa     1680

ggcgacagca taaaggctta cggagccggt ctcttgagct cattcgggga gctccagtac     1740

tgcctgtctg agaagcccaa gctgcttccc cttgaactcg aaaaaacagc tatccaaaac     1800

tatacagtaa ctgagttcca gcccttatat tacgtggcag agagcttcaa cgacgccaag     1860

gagaaagtcc gcaactttgc cgcaaccatt cctcggcctt tttccgtgcg ttacgatcca     1920

tacactcaga ggatcgaagt gctcgataac actcaacagc tcaagatttt ggcagacagc     1980

attaactcag agattggcat actttgtagc gcccttcaga agattaaata gaggctaggt     2040

ggaggctcag tgaaacttac tcacgtcatc cagcagagaa tggaaagtca aatttcctga     2100

attgctatgt gtctgggttt catccatccg acattgaagt tgacttactg aagaatggag     2160

agagaattga aaaagtggag cattcagact tgtctttcag caaggactgg tctttctatc     2220

tcttgtacta cactgaattc acccccactg aaaaagatga gtatgcctgc cgtgtgaacc     2280

atgtgacttt gtcacagccc aagatagtta agtggggtaa gtcttacatt cttttgtaag     2340

ctgctgaaag ttgtgtatga gtagtcatat cataaagctg ctttgatata aaaaaggtct     2400

atggccatac taccctgaat gagtcccatc ccatctgata taaacaatct gcatattggg     2460

attgtcaggg aatgttctta aagatcagat tagtggcacc tgctgagata ctgatgcaca     2520

gcatggtttc tgaaccagta gtttccctgc agttgagcag ggagcagcag cagcacttgc     2580

acaaatacat atacactctt aacacttctt acctactggc ttcctctagc ttttgtggca     2640

gcttcaggta tatttagcac tgaacgaaca tctcaagaag gtataggcct ttgtttgtaa     2700

gtcctgctgt cctagcatcc t                                               2721


<210> 12
<211> 3066
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      polynucleotide

<400> 12
gctatgtccc aggcactcta ctagacactt catacagttt agaaaatcag atgggtgtag       60

atcaaggcag gagcaggaac caaaaagaaa ggcataaaca taagaaaaaa aatggaaggg      120

gtggaaacag agtacaataa catgagtaat ttgatggggg ctattatgaa ctgagaaatg      180

aactttgaaa agtatcttgg ggccaaatca tgtagactct tgagtgatgt gttaaggaat      240

gctatgagtg ctgagagggc atcagaagtc cttgagagcc tccagagaaa ggctcttaaa      300

aatgcagcgc aatctccagt gacagaagat actgctagaa atctgctaga aaaaaaacaa      360

aaaaggcatg tatagaggaa ttatgaggga aagataccaa gtcacggttt attcttcaaa      420

atggaggtgg cttgttggga aggtggaagc tcatttggcc agagtggaaa tggaattggg      480

agaaatcgat gaccaaatgt aaacacttgg tgcctgatat agcttgacac caagttagcc      540

ccaagtgaaa taccctggca atattaatgt gtcttttccc gatattcctc aggtactccc      600

tgcagggagg gcagaggaag tcttctaaca tgcggtgacg tggaggagaa tcccggccct      660

actagtgcca ccatgaaaac gctgagccag gctcagagta aaacctcttc tcaacagttc      720

agtttcacag gcaactccag cgctaacgtc ataatcggta accagaaact gactattaat      780

gacgtggccc gagtcgctcg gaacgggaca ctcgtcagcc tgacaaataa tacagatatc      840

ctgcaaggca ttcaggccag ttgcgactac ataaacaacg cggttgagtc aggcgagcct      900

atttacgggg ttacgtccgg tttcggagga atggccaacg tggccatcag cagggagcag      960

gcttctgaat tgcagactaa tctcgtctgg ttcttgaaaa ccggggctgg gaataagctc     1020

ccactcgcag atgtcagggc cgctatgctg ttgcgggcta attcacacat gcgtggggca     1080

agcggcatcc ggcttgaact gattaagcga atggagattt ttttgaatgc cggggtgaca     1140

ccctacgtgt acgagttcgg cagcattggc gctagcgggg atcttgtccc cttatcatat     1200

attacaggca gcctgattgg actggacccc tcttttaagg ttgattttaa tggcaaggaa     1260

atggacgccc ccacagcctt gcgacagctg aacctgtctc ctcttactct gcttcctaaa     1320

gaaggcttgg ctatgatgaa tgggacatcc gtgatgactg gcattgcagc taactgtgtt     1380

tatgatactc aaattctgac agcaatagct atgggcgtcc atgccctcga cattcaggcc     1440

ttgaacggaa cgaatcaaag tttccatcca ttcattcata acagcaagcc tcaccccggg     1500

caactgtggg cagccgatca gatgatctca cttctggcaa atagccagct cgttcgagac     1560

gagctggacg gcaagcacga ttatagagac cacgaactga tccaggatag atactccctg     1620

agatgtctcc cacaatatct cggcccaatc gtggatggaa taagtcagat cgcaaaacaa     1680

atcgaaatag agattaacag cgtgactgac aacccactca tcgatgtgga caatcaagct     1740

agttaccatg gcggaaactt tcttggacag tacgtaggca tgggcatgga ccacctgcga     1800

tattacatcg gactcctcgc caagcatctc gacgtccaga tagcacttct ggccagtcct     1860

gaattttcta atggattgcc tccaagcttg ttgggaaacc gagaaagaaa ggtgaacatg     1920

ggactgaaag gcctgcagat ctgcggcaat tccattatgc cactcctgac cttttacgga     1980

aacagtattg ctgacaggtt tcctacccac gctgagcaat ttaaccagaa tatcaattct     2040

caggggtaca cctccgccac tctggcacga cgatccgttg acatcttcca aaattacgtc     2100

gctattgcgt tgatgtttgg agtgcaagcg gtagacctcc ggacttataa gaaaactggg     2160

cattatgatg ccagagccag cctcagcccc gccaccgaac gtttatacag tgcagtgaga     2220

catgtggtgg gccagaagcc cacaagcgac cggccgtata tttggaatga taatgaacag     2280

ggtctggacg aacacatcgc tcgcatttca gctgatattg ctgccggtgg agtgattgtc     2340

caagctgtgc aggatatact tcccagtctt cactagaggc taggtggagg ctcagtgaaa     2400

cttactcacg tcatccagca gagaatggaa agtcaaattt cctgaattgc tatgtgtctg     2460

ggtttcatcc atccgacatt gaagttgact tactgaagaa tggagagaga attgaaaaag     2520

tggagcattc agacttgtct ttcagcaagg actggtcttt ctatctcttg tactacactg     2580

aattcacccc cactgaaaaa gatgagtatg cctgccgtgt gaaccatgtg actttgtcac     2640

agcccaagat agttaagtgg ggtaagtctt acattctttt gtaagctgct gaaagttgtg     2700

tatgagtagt catatcataa agctgctttg atataaaaaa ggtctatggc catactaccc     2760

tgaatgagtc ccatcccatc tgatataaac aatctgcata ttgggattgt cagggaatgt     2820

tcttaaagat cagattagtg gcacctgctg agatactgat gcacagcatg gtttctgaac     2880

cagtagtttc cctgcagttg agcagggagc agcagcagca cttgcacaaa tacatataca     2940

ctcttaacac ttcttaccta ctggcttcct ctagcttttg tggcagcttc aggtatattt     3000

agcactgaac gaacatctca agaaggtata ggcctttgtt tgtaagtcct gctgtcctag     3060

catcct                                                                3066


<210> 13
<211> 4221
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      polynucleotide

<400> 13
gctatgtccc aggcactcta ctagacactt catacagttt agaaaatcag atgggtgtag       60

atcaaggcag gagcaggaac caaaaagaaa ggcataaaca taagaaaaaa aatggaaggg      120

gtggaaacag agtacaataa catgagtaat ttgatggggg ctattatgaa ctgagaaatg      180

aactttgaaa agtatcttgg ggccaaatca tgtagactct tgagtgatgt gttaaggaat      240

gctatgagtg ctgagagggc atcagaagtc cttgagagcc tccagagaaa ggctcttaaa      300

aatgcagcgc aatctccagt gacagaagat actgctagaa atctgctaga aaaaaaacaa      360

aaaaggcatg tatagaggaa ttatgaggga aagataccaa gtcacggttt attcttcaaa      420

atggaggtgg cttgttggga aggtggaagc tcatttggcc agagtggaaa tggaattggg      480

agaaatcgat gaccaaatgt aaacacttgg tgcctgatat agcttgacac caagttagcc      540

ccaagtgaaa taccctggca atattaatgt gtcttttccc gatattcctc aggtactccc      600

tgcagggagg gcagaggaag tcttctaaca tgcggtgacg tggaggagaa tcccggccct      660

actagtgcca ccatgggagt gcggcatcct ccttgcagcc atagacttct cgccgtttgc      720

gctctcgttt cccttgctac ggctgcactc ttgggacaca tactgcttca tgatttcctc      780

cttgtgccaa gagaactctc tggcagctcc ccagtgctgg aagagactca tcccgcacac      840

caacagggtg cctccagacc cggcccgcgc gatgcccagg ctcaccctgg cagacctaga      900

gcagttccga ctcagtgtga cgtcccacct aatagccgct tcgattgcgc accggacaag      960

gccatcactc aggagcagtg tgaggcaagg ggatgctgtt acatccccgc taaacagggt     1020

cttcagggag cgcagatggg tcagccttgg tgcttctttc ccccaagtta tccgtcatac     1080

aagttggaga atctctcaag ctccgaaatg ggatacaccg ccacacttac taggacaacg     1140

ccgaccttct ttcccaagga catcctgacg ctccggctgg acgtgatgat ggagacagag     1200

aacagattgc actttactat caaggacccc gccaaccggc gctacgaagt gcctctggaa     1260

acaccacacg tgcattctcg agccccttct ccactgtata gtgttgaatt ctctgaggag     1320

ccattcggcg tgatcgtacg tagacagctt gatggtcgcg tcttgctgaa taccacggtt     1380

gctccattgt tcttcgcgga tcagttcttg cagctgtcaa ctagtctgcc ctctcagtac     1440

attaccgggt tggccgagca cctgtcccca ctcatgctgt ctacatcctg gacgaggata     1500

actttgtgga accgcgacct ggctccgacc ccaggtgcta atctgtacgg aagccaccca     1560

ttttacctgg cccttgagga cggtggaagt gctcatgggg tgtttctgtt gaactctaac     1620

gcaatggatg tcgtactgca gccgagtccg gctctgagtt ggcggtccac cggtggcatc     1680

ttagacgtgt acattttcct cgggcccgag cccaaatccg tggtacagca gtacctggac     1740

gttgttggct acccctttat gccgccttac tggggcctcg ggtttcattt gtgtcggtgg     1800

ggatacagct ctactgcaat cactagacag gtagttgaaa atatgacacg ggcacacttt     1860

cccttggacg tgcagtggaa tgacttggac tacatggatt cacgccggga cttcacattc     1920

aacaaagacg ggtttagaga ctttcccgcg atggtccagg agctgcatca aggaggaagg     1980

cgctacatga tgatagtcga ccctgccatt agcagctcag gccctgctgg gagctatcgc     2040

ccgtatgacg aagggttgcg aagaggcgta ttcataacaa atgaaacagg gcagcctctc     2100

ataggtaagg tttggcccgg gagcaccgcc tttccagact tcacaaatcc aacagctctt     2160

gcatggtggg aggacatggt cgctgagttc catgatcagg tgccattcga tggaatgtgg     2220

atcgatatga acgaacccag caacttcata cgcggtagcg aagacggatg tcccaacaac     2280

gaactggaga acccaccata tgtgcctgga gttgtgggtg ggacactcca ggcggctact     2340

atctgcgcct cttcccacca gttcttaagc acacattaca atctgcataa tctgtacggg     2400

ctcacagagg ccatcgcgtc tcatagggca ctggtgaagg cccgcggaac ccgacccttc     2460

gtgatcagcc gcagtacttt tgcagggcat ggtcggtacg cagggcattg gactggggac     2520

gtatggtcat cttgggagca gctggcttca agcgtccctg aaattcttca gtttaattta     2580

ctgggggtgc cacttgtggg ggcggacgtg tgcggcttcc tcgggaatac aagcgaagaa     2640

ctctgtgtgc gctggacaca gctgggcgct ttctacccgt tcatgcgtaa tcataattcc     2700

ttgctgtctc tgccccagga gccttacagc ttttctgaac cagcccagca ggccatgcgc     2760

aaggctctga ctctgcgcta cgctctgctc ccccatctct atacactctt tcaccaggct     2820

catgtagcag gggagacggt tgcgcgaccc ctgtttttag agttccccaa ggattcttca     2880

acctggaccg tagaccatca gctgttgtgg ggcgaggccc tgctgattac tccggtattg     2940

caagccggga aggctgaggt gaccggttac tttccgttag gcacctggta tgatctgcag     3000

acagtgcctg tggaggcttt gggatccctt cccccaccac cggccgctcc acgagagcca     3060

gctattcaca gcgaagggca gtgggtcacc ttacccgccc cactggacac cataaacgtc     3120

catctgcgtg ccggatatat catccctctc cagggcccag gccttactac gacagagagc     3180

cggcagcagc ccatggcctt ggctgtggct ctgacaaagg gtggtgaagc caggggcgag     3240

ctgttttggg atgacggaga aagtctggag gtgctggaga ggggcgctta cacacaggta     3300

atttttctcg cccgtaacaa tacgatcgtc aacgagcttg tccgtgttac cagcgagggg     3360

gctggcctgc aactccagaa agtcaccgtt ctgggtgtag caaccgcccc ccaacaggtg     3420

ctgtccaatg gtgtaccagt cagtaatttc acctattccc ctgacacgaa agtgcttgat     3480

atctgtgtct ctttactgat gggtgagcaa ttcctggtga gctggtgcta gaggctaggt     3540

ggaggctcag tgaaacttac tcacgtcatc cagcagagaa tggaaagtca aatttcctga     3600

attgctatgt gtctgggttt catccatccg acattgaagt tgacttactg aagaatggag     3660

agagaattga aaaagtggag cattcagact tgtctttcag caaggactgg tctttctatc     3720

tcttgtacta cactgaattc acccccactg aaaaagatga gtatgcctgc cgtgtgaacc     3780

atgtgacttt gtcacagccc aagatagtta agtggggtaa gtcttacatt cttttgtaag     3840

ctgctgaaag ttgtgtatga gtagtcatat cataaagctg ctttgatata aaaaaggtct     3900

atggccatac taccctgaat gagtcccatc ccatctgata taaacaatct gcatattggg     3960

attgtcaggg aatgttctta aagatcagat tagtggcacc tgctgagata ctgatgcaca     4020

gcatggtttc tgaaccagta gtttccctgc agttgagcag ggagcagcag cagcacttgc     4080

acaaatacat atacactctt aacacttctt acctactggc ttcctctagc ttttgtggca     4140

gcttcaggta tatttagcac tgaacgaaca tctcaagaag gtataggcct ttgtttgtaa     4200

gtcctgctgt cctagcatcc t                                               4221


<210> 14
<211> 5736
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      polynucleotide

<400> 14
gctatgtccc aggcactcta ctagacactt catacagttt agaaaatcag atgggtgtag       60

atcaaggcag gagcaggaac caaaaagaaa ggcataaaca taagaaaaaa aatggaaggg      120

gtggaaacag agtacaataa catgagtaat ttgatggggg ctattatgaa ctgagaaatg      180

aactttgaaa agtatcttgg ggccaaatca tgtagactct tgagtgatgt gttaaggaat      240

gctatgagtg ctgagagggc atcagaagtc cttgagagcc tccagagaaa ggctcttaaa      300

aatgcagcgc aatctccagt gacagaagat actgctagaa atctgctaga aaaaaaacaa      360

aaaaggcatg tatagaggaa ttatgaggga aagataccaa gtcacggttt attcttcaaa      420

atggaggtgg cttgttggga aggtggaagc tcatttggcc agagtggaaa tggaattggg      480

agaaatcgat gaccaaatgt aaacacttgg tgcctgatat agcttgacac caagttagcc      540

ccaagtgaaa taccctggca atattaatgt gtcttttccc gatattcctc aggtactccc      600

tgcagggagg gcagaggaag tcttctaaca tgcggtgacg tggaggagaa tcccggccct      660

actagtgcca ccatgcagat tgagctctca acttgcttct ttttgtgtct cctgagattt      720

tgctttagcg ccaccagacg ttactacctc ggggccgtcg aactgagttg ggactacatg      780

cagtcagacc tgggtgagct gccagttgat gcacggttcc caccccgagt ccccaagagc      840

ttccccttca acacatccgt cgtgtataag aagactctgt tcgtggagtt caccgaccac      900

ctgtttaata tcgctaaacc tcgtccaccc tggatgggcc tgcttggccc caccatacag      960

gccgaagtct acgacactgt tgttatcaca ctgaagaaca tggcgagcca cccagtatcc     1020

ctccatgctg taggagtgag ctactggaaa gcgtcagaag gcgccgagta tgatgaccaa     1080

acctcccaga gggaaaagga agacgataag gtgttccctg gcggatcaca cacttatgtc     1140

tggcaggtct tgaaggaaaa tggaccaatg gcaagcgacc cactctgtct cacctactct     1200

tacctcagtc atgtagatct ggtgaaagat cttaactctg ggctgattgg agctctcctc     1260

gtgtgcaggg agggctcact ggccaaagaa aagactcaaa ccctgcacaa gttcattctt     1320

ctgtttgccg ttttcgacga ggggaaaagt tggcactcag agactaagaa ttctctgatg     1380

caggatcgag acgctgctag tgcccgggca tggcccaaaa tgcatacagt gaacggttac     1440

gtgaaccgct cattgcctgg actgattggg tgtcatagaa agtccgttta ttggcacgtc     1500

attgggatgg ggaccacacc cgaagttcac tcaatttttc tggaaggcca tactttcctt     1560

gtgaggaatc accggcaagc aagtctcgag ataagtccaa ttacattcct gaccgcccaa     1620

acgctgctta tggacttggg tcagttcctc ctgttctgcc atatatccag ccaccagcat     1680

gacggcatgg aggcctacgt gaaagttgat tcatgtcccg aggagccaca gttacgtatg     1740

aaaaacaatg aggaagccga ggactatgat gacgatctca ctgactcaga gatggatgtt     1800

gtgcgcttcg atgatgataa ctctccttcc tttatacaga tccgcagcgt ggcaaagaaa     1860

catcctaaga cttgggtcca ttacattgct gccgaagaag aggattggga ctatgcccca     1920

ttagtgttag caccagatga cagaagctac aagtcccagt atctcaacaa cggacctcag     1980

agaatcggta gaaaatacaa aaaggtccgc ttcatggctt acacagatga gactttcaaa     2040

actcgtgaag cgatacagca cgaatcagga atcctcgggc ctctgcttta tggcgaggtc     2100

ggcgacactc tgctgattat ttttaaaaat caggcaagcc gtccgtacaa catatatcca     2160

cacgggatca cagatgtacg gccactctat tcccgccgct tgcccaaagg tgtgaaacat     2220

ttaaaggatt ttcctatact ccctggagaa atattcaagt acaaatggac agtgactgtc     2280

gaggatgggc ccacgaagtc cgaccctcgg tgtctgactc gctactattc atcctttgtg     2340

aatatggagc gcgacttagc ttccgggctc attggacccc tgcttatctg ctataaagaa     2400

agtgtcgacc aaagaggcaa ccagatcatg tccgataaaa ggaatgtgat tcttttcagt     2460

gtgtttgacg aaaaccggag ttggtatctt accgagaaca ttcaacgctt cttacctaac     2520

ccagctggcg tgcaactcga agaccctgaa ttccaagcgt ccaatataat gcactcaatc     2580

aatggctacg tgtttgacag cctgcaattg agtgtgtgcc tccacgaggt ggcttactgg     2640

tacatcctgt ctatcggcgc ccagaccgat tttctttccg tcttcttcag cggttacacc     2700

tttaagcata aaatggtgta cgaggacact cttacactgt tcccgttttc tggcgagacc     2760

gtgtttatgt caatggaaaa tcccggtctg tggatcctgg ggtgccataa ttctgatttc     2820

agaaaccggg gtatgacagc actgctgaag gtttccagct gtgacaaaaa caccggcgac     2880

tattacgagg attcctacga ggatatttcc gcctacctcc tgagcaaaaa caacgccatt     2940

gagccccgga gttttagcca gaaccctcca gtccttaagc ggcaccagcg cgaaataact     3000

cggacgacct tacagtccga tcaggaagag attgactatg atgacacaat ctccgttgag     3060

atgaaaaaag aggactttga tatttatgat gaggacgaaa accaatcccc caggagcttc     3120

cagaaaaaga cgcggcatta ttttatcgcc gccgtggaaa gactctggga ctatggaatg     3180

agctccagcc cccacgtgtt gcgaaaccgc gctcagtctg ggtccgtccc acagtttaag     3240

aaggtcgtct ttcaggaatt tacagatggg tcttttactc aacctcttta ccgaggcgag     3300

ctgaatgagc atctcggcct gctgggaccc tatattaggg ctgaggtgga agacaacatt     3360

atggtcactt tccgcaacca ggcatcaaga ccatattcct tctattcctc ccttatcagt     3420

tatgaggagg accagcgtca aggcgcggaa cctaggaaaa atttcgttaa acctaacgag     3480

accaaaacct acttctggaa ggtccaacat cacatggcgc ccacaaagga cgagttcgat     3540

tgcaaagcgt gggcttactt cagcgacgta gacctcgaaa aggacgtgca tagtggactg     3600

atcggaccgc tgctggtgtg ccacacgaac acccttaatc cagcccacgg ccgccaagtc     3660

acagtccaag agtttgccct cttcttcacg atcttcgacg aaaccaagag ctggtatttt     3720

acagagaaca tggagaggaa ctgtcgtgcg ccatgtaata tccaaatgga ggaccccacc     3780

ttcaaagaga actatcgatt tcacgctatc aacgggtata ttatggacac acttcccggc     3840

ttggtgatgg ctcaggacca gaggattcgg tggtaccttc tgtctatggg gagcaatgaa     3900

aatatccatt ccatccattt ttctggccac gtttttactg tcagaaaaaa agaggagtac     3960

aaaatggctc tgtacaatct ttaccctggg gtatttgaaa ctgtcgaaat gttgccatct     4020

aaagcgggaa tatggcgcgt cgagtgtctc attggagagc atttgcacgc aggaatgagc     4080

accctgttcc tcgtgtacag taacaaatgt cagacccctc ttggtatggc ttcaggccat     4140

atccgggact ttcagattac agcatctggc cagtatggac aatgggcgcc caagctggcc     4200

cgactgcatt acagcggctc tatcaacgct tggagtacga aggaaccctt ttcctggata     4260

aaggtcgatc tgctggcccc tatgataatc cacggaatca agacccaggg ggcccgccaa     4320

aagttctcaa gcctgtatat ttcacaattc attatcatgt acagcttgga tgggaagaag     4380

tggcagactt atcgggggaa cagtaccggc accctgatgg tcttttttgg aaacgttgac     4440

agttcaggca ttaaacataa tatctttaac cccccgatta tcgcccggta tatccgcctg     4500

caccccacac attacagtat acgtagcact ttgagaatgg agctgatggg atgtgatctc     4560

aacagctgtt ccatgccatt gggcatggaa agcaaggcca tcagtgatgc acagataact     4620

gcttcaagtt atttcaccaa tatgtttgcg acctggtcac ctagtaaagc acgcctgcat     4680

cttcaaggcc ggagtaatgc ctggcgaccc caggtgaaca accccaagga gtggttacag     4740

gtcgatttcc agaaaaccgt gaaggtcaca ggcgttacaa cccagggcgt gaaaagcctc     4800

ctcacctcta tgtacgtcaa ggaattcttg atttcctcaa gtcaggacgg acatcagtgg     4860

accctgttct ttcagaacgg aaaagtcaag gtgtttcagg ggaaccagga ctcttttacg     4920

cccgtggtca attctcttga tcctcccctc cttaccagat atctgaggat tcacccccag     4980

tcatgggtcc atcagatcgc gctcagaatg gaggtgctgg ggtgcgaggc acaggatttg     5040

tactagaggc taggtggagg ctcagtgaaa cttactcacg tcatccagca gagaatggaa     5100

agtcaaattt cctgaattgc tatgtgtctg ggtttcatcc atccgacatt gaagttgact     5160

tactgaagaa tggagagaga attgaaaaag tggagcattc agacttgtct ttcagcaagg     5220

actggtcttt ctatctcttg tactacactg aattcacccc cactgaaaaa gatgagtatg     5280

cctgccgtgt gaaccatgtg actttgtcac agcccaagat agttaagtgg ggtaagtctt     5340

acattctttt gtaagctgct gaaagttgtg tatgagtagt catatcataa agctgctttg     5400

atataaaaaa ggtctatggc catactaccc tgaatgagtc ccatcccatc tgatataaac     5460

aatctgcata ttgggattgt cagggaatgt tcttaaagat cagattagtg gcacctgctg     5520

agatactgat gcacagcatg gtttctgaac cagtagtttc cctgcagttg agcagggagc     5580

agcagcagca cttgcacaaa tacatataca ctcttaacac ttcttaccta ctggcttcct     5640

ctagcttttg tggcagcttc aggtatattt agcactgaac gaacatctca agaaggtata     5700

ggcctttgtt tgtaagtcct gctgtcctag catcct                               5736


<210> 15
<211> 8418
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      polynucleotide

<400> 15
gctatgtccc aggcactcta ctagacactt catacagttt agaaaatcag atgggtgtag       60

atcaaggcag gagcaggaac caaaaagaaa ggcataaaca taagaaaaaa aatggaaggg      120

gtggaaacag agtacaataa catgagtaat ttgatggggg ctattatgaa ctgagaaatg      180

aactttgaaa agtatcttgg ggccaaatca tgtagactct tgagtgatgt gttaaggaat      240

gctatgagtg ctgagagggc atcagaagtc cttgagagcc tccagagaaa ggctcttaaa      300

aatgcagcgc aatctccagt gacagaagat actgctagaa atctgctaga aaaaaaacaa      360

aaaaggcatg tatagaggaa ttatgaggga aagataccaa gtcacggttt attcttcaaa      420

atggaggtgg cttgttggga aggtggaagc tcatttggcc agagtggaaa tggaattggg      480

agaaatcgat gaccaaatgt aaacacttgg tgcctgatat agcttgacac caagttagcc      540

ccaagtgaaa taccctggca atattaatgt gtcttttccc gatattcctc aggtactccc      600

tgcagggagg gcagaggaag tcttctaaca tgcggtgacg tggaggagaa tcccggccct      660

actagtgcca ccatgcaaat agagctctcc acctgcttct ttctgtgcct tttgcgattc      720

tgctttagtg ccaccagaag atactacctg ggtgcagtgg aactgtcatg ggactatatg      780

caaagtgatc tcggtgagct gcctgtggac gcaagatttc ctcctagagt gccaaaatct      840

tttccattca acacctcagt cgtgtacaaa aagactctgt ttgtagaatt cacggatcac      900

cttttcaaca tcgctaagcc aaggccaccc tggatgggtc tgctaggtcc taccatccag      960

gctgaggttt atgatacagt ggtcattaca cttaagaaca tggcttccca tcctgtcagt     1020

cttcatgctg ttggtgtatc ctactggaaa gcttctgagg gagctgaata tgatgatcag     1080

accagtcaaa gggagaaaga agatgataaa gtcttccctg gtggaagcca tacatatgtc     1140

tggcaggtcc tgaaagagaa tggtccaatg gcctctgacc cactgtgcct tacctactca     1200

tatctttctc atgtggacct ggtaaaagac ttgaattcag gcctcattgg agccctacta     1260

gtatgtagag aagggagtct ggccaaggaa aagacacaga ccttgcacaa atttatacta     1320

ctttttgctg tatttgatga agggaaaagt tggcactcag aaacaaagaa ctccttgatg     1380

caggataggg atgctgcatc tgctcgggcc tggcctaaaa tgcacacagt caatggttat     1440

gtaaacaggt ctctgccagg tctgattgga tgccacagga aatcagtcta ttggcatgtg     1500

attggaatgg gcaccactcc tgaagtgcac tcaatattcc tcgaaggtca cacatttctt     1560

gtgaggaacc atcgccaggc gtccttggaa atctcgccaa taactttcct tactgctcaa     1620

acactcttga tggaccttgg acagtttcta ctgttttgtc atatctcttc ccaccaacat     1680

gatggcatgg aagcttatgt caaagtagac agctgtccag aggaacccca actacgaatg     1740

aaaaataatg aagaagcgga agactatgat gatgatctta ctgattctga aatggatgtg     1800

gtcaggtttg atgatgacaa ctctccttcc tttatccaaa ttcgctcagt tgccaagaag     1860

catcctaaaa cttgggtaca ttacattgct gctgaagagg aggactggga ctatgctccc     1920

ttagtcctcg cccccgatga cagaagttat aaaagtcaat atttgaacaa tggccctcag     1980

cggattggta ggaagtacaa aaaagtccga tttatggcat acacagatga aacctttaag     2040

actcgtgaag ctattcagca tgaatcagga atcttgggac ctttacttta tggggaagtt     2100

ggagacacac tgttgattat atttaagaat caagcaagca gaccatataa catctaccct     2160

cacggaatca ctgatgtccg tcctttgtat tcaaggagat taccaaaagg tgtaaaacat     2220

ttgaaggatt ttccaattct gccaggagaa atattcaaat ataaatggac agtgactgta     2280

gaagatgggc caactaaatc agatcctcgg tgcctgaccc gctattactc tagtttcgtt     2340

aatatggaga gagatctagc ttcaggactc attggccctc tcctcatctg ctacaaagaa     2400

tctgtagatc aaagaggaaa ccagataatg tcagacaaga ggaatgtcat cctgttttct     2460

gtatttgatg agaaccgaag ctggtacctc acagagaata tacaacgctt tctccccaat     2520

ccagctggag tgcagcttga ggatccagag ttccaagcct ccaacatcat gcacagcatc     2580

aatggctatg tttttgatag tttgcagttg tcagtttgtt tgcatgaggt ggcatactgg     2640

tacattctaa gcattggagc acagactgac ttcctttctg tcttcttctc tggatatacc     2700

ttcaaacaca aaatggtcta tgaagacaca ctcaccctat tcccattctc aggagaaact     2760

gtcttcatgt cgatggaaaa cccaggtcta tggattctgg ggtgccacaa ctcagacttt     2820

cggaacagag gcatgaccgc cttactgaag gtttctagtt gtgacaagaa cactggtgat     2880

tattacgagg acagttatga agatatttca gcatacttgc tgagtaaaaa caatgccatt     2940

gaaccaagaa gcttctccca gaattcaaga caccctagca ctaggcaaaa gcaatttaat     3000

gccaccacaa ttccagaaaa tgacatagag aagactgacc cttggtttgc acacagaaca     3060

cctatgccta aaatacaaaa tgtctcctct agtgatttgt tgatgctctt gcgacagagt     3120

cctactccac atgggctatc cttatctgat ctccaagaag ccaaatatga gactttttct     3180

gatgatccat cacctggagc aatagacagt aataacagcc tgtctgaaat gacacacttc     3240

aggccacagc tccatcacag tggggacatg gtatttaccc ctgagtcagg cctccaatta     3300

agattaaatg agaaactggg gacaactgca gcaacagagt tgaagaaact tgatttcaaa     3360

gtttctagta catcaaataa tctgatttca acaattccat cagacaattt ggcagcaggt     3420

actgataata caagttcctt aggaccccca agtatgccag ttcattatga tagtcaatta     3480

gataccactc tatttggcaa aaagtcatct ccccttactg agtctggtgg acctctgagc     3540

ttgagtgaag aaaataatga ttcaaagttg ttagaatcag gtttaatgaa tagccaagaa     3600

agttcatggg gaaaaaatgt atcgtcaaca gagagtggta ggttatttaa agggaaaaga     3660

gctcatggac ctgctttgtt gactaaagat aatgccttat tcaaagttag catctctttg     3720

ttaaagacaa acaaaacttc caataattca gcaactaata gaaagactca cattgatggc     3780

ccatcattat taattgagaa tagtccatca gtctggcaaa atatattaga aagtgacact     3840

gagtttaaaa aagtgacacc tttgattcat gacagaatgc ttatggacaa aaatgctaca     3900

gctttgaggc taaatcatat gtcaaataaa actacttcat caaaaaacat ggaaatggtc     3960

caacagaaaa aagagggccc cattccacca gatgcacaaa atccagatat gtcgttcttt     4020

aagatgctat tcttgccaga atcagcaagg tggatacaaa ggactcatgg aaagaactct     4080

ctgaactctg ggcaaggccc cagtccaaag caattagtat ccttaggacc agaaaaatct     4140

gtggaaggtc agaatttctt gtctgagaaa aacaaagtgg tagtaggaaa gggtgaattt     4200

acaaaggacg taggactcaa agagatggtt tttccaagca gcagaaacct atttcttact     4260

aacttggata atttacatga aaataataca cacaatcaag aaaaaaaaat tcaggaagaa     4320

atagaaaaga aggaaacatt aatccaagag aatgtagttt tgcctcagat acatacagtg     4380

actggcacta agaatttcat gaagaacctt ttcttactga gcactaggca aaatgtagaa     4440

ggttcatatg acggggcata tgctccagta cttcaagatt ttaggtcatt aaatgattca     4500

acaaatagaa caaagaaaca cacagctcat ttctcaaaaa aaggggagga agaaaacttg     4560

gaaggcttgg gaaatcaaac caagcaaatt gtagagaaat atgcatgcac cacaaggata     4620

tctcctaata caagccagca gaattttgtc acgcaacgta gtaagagagc tttgaaacaa     4680

ttcagactcc cactagaaga aacagaactt gaaaaaagga taattgtgga tgacacctca     4740

acccagtggt ccaaaaacat gaaacatttg accccgagca ccctcacaca gatagactac     4800

aatgagaagg agaaaggggc cattactcag tctcccttat cagattgcct tacgaggagt     4860

catagcatcc ctcaagcaaa tagatctcca ttacccattg caaaggtatc atcatttcca     4920

tctattagac ctatatatct gaccagggtc ctattccaag acaactcttc tcatcttcca     4980

gcagcatctt atagaaagaa agattctggg gtccaagaaa gcagtcattt cttacaagga     5040

gccaaaaaaa ataacctttc tttagccatt ctaaccttgg agatgactgg tgatcaaaga     5100

gaggttggct ccctggggac aagtgccaca aattcagtca catacaagaa agttgagaac     5160

actgttctcc cgaaaccaga cttgcccaaa acatctggca aagttgaatt gcttccaaaa     5220

gttcacattt atcagaagga cctattccct acggaaacta gcaatgggtc tcctggccat     5280

ctggatctcg tggaagggag ccttcttcag ggaacagagg gagcgattaa gtggaatgaa     5340

gcaaacagac ctggaaaagt tccctttctg agagtagcaa cagaaagctc tgcaaagact     5400

ccctccaagc tattggatcc tcttgcttgg gataaccact atggtactca gataccaaaa     5460

gaagagtgga aatcccaaga gaagtcacca gaaaaaacag cttttaagaa aaaggatacc     5520

attttgtccc tgaacgcttg tgaaagcaat catgcaatag cagcaataaa tgagggacaa     5580

aataagcccg aaatagaagt cacctgggca aagcaaggta ggactgaaag gctgtgctct     5640

caaaacccac cagtcttgaa acgccatcaa cgggaaataa ctcgtactac tcttcagtca     5700

gatcaagagg aaattgacta tgatgatacc atatcagttg aaatgaagaa ggaagatttt     5760

gacatttatg atgaggatga aaatcagagc ccccgcagct ttcaaaagaa aacacgacac     5820

tattttattg ctgcagtgga gaggctctgg gattatggga tgagtagctc cccacatgtt     5880

ctaagaaaca gggctcagag tggcagtgtc cctcagttca agaaagttgt tttccaggaa     5940

tttactgatg gctcctttac tcagccctta taccgtggag aactaaatga acatttggga     6000

ctcctggggc catatataag agcagaagtt gaagataata tcatggtaac tttcagaaat     6060

caggcctctc gtccctattc cttctattct agccttattt cttatgagga agatcagagg     6120

caaggagcag aacctagaaa aaactttgtc aagcctaatg aaaccaaaac ttacttttgg     6180

aaagtgcaac atcatatggc acccactaaa gatgagtttg actgcaaagc ctgggcttat     6240

ttctctgatg ttgacctgga aaaagatgtg cactcaggcc tgattggacc ccttctggtc     6300

tgccacacta acacactgaa ccctgctcat gggagacaag tgacagtaca ggaatttgct     6360

ctgtttttca ccatctttga tgagaccaaa agctggtact tcactgaaaa tatggaaaga     6420

aactgcaggg ctccctgcaa tatccagatg gaagatccca cttttaaaga gaattatcgc     6480

ttccatgcaa tcaatggcta cataatggat acactacctg gcttagtaat ggctcaggat     6540

caaaggattc gatggtatct gctcagcatg ggcagcaatg aaaacatcca ttctattcat     6600

ttcagtggac atgtgttcac tgtacgaaaa aaagaggagt ataaaatggc actgtacaat     6660

ctctatccag gtgtttttga gacagtggaa atgttaccat ccaaagctgg aatttggcgg     6720

gtggaatgcc ttattggcga gcatctacat gctgggatga gcacactttt tctggtgtac     6780

agcaataagt gtcagactcc cctgggaatg gcttctggac acattagaga ttttcagatt     6840

acagcttcag gacaatatgg acagtgggcc ccaaagctgg ccagacttca ttattccgga     6900

tcaatcaatg cctggagcac caaggagccc ttttcttgga tcaaggtgga tctgttggca     6960

ccaatgatta ttcacggcat caagacccag ggtgcccgtc agaagttctc cagcctctac     7020

atctctcagt ttatcatcat gtatagtctt gatgggaaga agtggcagac ttatcgagga     7080

aattccactg gaaccttaat ggtcttcttt ggcaatgtgg attcatctgg gataaaacac     7140

aatattttta accctccaat tattgctcga tacatccgtt tgcacccaac tcattatagc     7200

attcgcagca ctcttcgcat ggagttgatg ggctgtgatt taaatagttg cagcatgcca     7260

ttgggaatgg agagtaaagc aatatcagat gcacagatta ctgcttcatc ctactttacc     7320

aatatgtttg ccacctggtc tccttcaaaa gctcgacttc acctccaagg gaggagtaat     7380

gcctggagac ctcaggtgaa taatccaaaa gagtggctgc aagtggactt ccagaagaca     7440

atgaaagtca caggagtaac tactcaggga gtaaaatctc tgcttaccag catgtatgtg     7500

aaggagttcc tcatctccag cagtcaagat ggccatcagt ggactctctt ttttcagaat     7560

ggcaaagtaa aggtttttca gggaaatcaa gactccttca cacctgtggt gaactctcta     7620

gacccaccgt tactgactcg ctaccttcga attcaccccc agagttgggt gcaccagatt     7680

gccctgagga tggaggttct gggctgcgag gcacaggacc tctactgaag gctaggtgga     7740

ggctcagtga aacttactca cgtcatccag cagagaatgg aaagtcaaat ttcctgaatt     7800

gctatgtgtc tgggtttcat ccatccgaca ttgaagttga cttactgaag aatggagaga     7860

gaattgaaaa agtggagcat tcagacttgt ctttcagcaa ggactggtct ttctatctct     7920

tgtactacac tgaattcacc cccactgaaa aagatgagta tgcctgccgt gtgaaccatg     7980

tgactttgtc acagcccaag atagttaagt ggggtaagtc ttacattctt ttgtaagctg     8040

ctgaaagttg tgtatgagta gtcatatcat aaagctgctt tgatataaaa aaggtctatg     8100

gccatactac cctgaatgag tcccatccca tctgatataa acaatctgca tattgggatt     8160

gtcagggaat gttcttaaag atcagattag tggcacctgc tgagatactg atgcacagca     8220

tggtttctga accagtagtt tccctgcagt tgagcaggga gcagcagcag cacttgcaca     8280

aatacatata cactcttaac acttcttacc tactggcttc ctctagcttt tgtggcagct     8340

tcaggtatat ttagcactga acgaacatct caagaaggta taggcctttg tttgtaagtc     8400

ctgctgtcct agcatcct                                                   8418


<210> 16
<211> 2610
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      polynucleotide

<400> 16
gctatgtccc aggcactcta ctagacactt catacagttt agaaaatcag atgggtgtag       60

atcaaggcag gagcaggaac caaaaagaaa ggcataaaca taagaaaaaa aatggaaggg      120

gtggaaacag agtacaataa catgagtaat ttgatggggg ctattatgaa ctgagaaatg      180

aactttgaaa agtatcttgg ggccaaatca tgtagactct tgagtgatgt gttaaggaat      240

gctatgagtg ctgagagggc atcagaagtc cttgagagcc tccagagaaa ggctcttaaa      300

aatgcagcgc aatctccagt gacagaagat actgctagaa atctgctaga aaaaaaacaa      360

aaaaggcatg tatagaggaa ttatgaggga aagataccaa gtcacggttt attcttcaaa      420

atggaggtgg cttgttggga aggtggaagc tcatttggcc agagtggaaa tggaattggg      480

agaaatcgat gaccaaatgt aaacacttgg tgcctgatat agcttgacac caagttagcc      540

ccaagtgaaa taccctggca atattaatgt gtcttttccc gatattcctc aggtactccc      600

tgcagggagg gcagaggaag tcttctaaca tgcggtgacg tggaggagaa tcccggccct      660

actagtgcca ccatggaaac cgatacactg ctgctgtggg tgctgctgct gtgggtgcca      720

ggatctaccg gtcagtctgt gttgacgcag ccgccctcag tgtctgcggc cccaggacag      780

agggtcacca tctcctgctc tggaaccagg tccaacattg ggagtgatta tgtttcctgg      840

taccaacacc tcccaggaac agcccccaaa ctcctcgttt atggcgataa tctgcgaccc      900

tcagggattc ctgaccgatt ctctgcctcc aagtctggca cgtcagccac cctgggcatc      960

accggactcc agactgggga cgaggccgat tattactgcg gcacatggga ttacaccctg     1020

aatggtgtgg tgttcggcgg agggaccaag ctgaccgtcc taggttctag aggtggtggt     1080

ggtagcggcg gcggcggctc tggtggtggt ggatccctcg agatggccca ggtgcagctg     1140

gtggagtctg ggggaggctt ggtacagcct ggggggtccc tgagactctc ctgtgcagcc     1200

tctggattca cctttagcag ctatgccatg agctgggtcc gccaggctcc agggaagggg     1260

ctggagtggg tctcagttat ttatagcggt ggtagtagca catactatgc agactccgtg     1320

aagggccggt tcaccatctc cagagataat tccaagaaca cgctgtatct gcaaatgaac     1380

agcctgagag ccgaggacac ggccgtatat tactgtgcgc gcacttctta cctgaaccat     1440

ggtgattact ggggtcaagg tactctggtg accgtgtcta gcgccgctgc attcgtgcct     1500

gtgttcctcc cagctaagcc cactaccacc cccgctccaa ggccgcccac gcccgctcct     1560

actattgcta gtcagccttt aagtttacga cccgaagctt gcaggcccgc cgccggcggc     1620

gctgtgcaca ccagggggct tgattttgcc tgcgactttt gggtattggt agtggtgggc     1680

ggagttttag cctgctacag cctcctggta acagtggctt ttatcatctt ttgggtgagg     1740

aaacgatggc agaacgagaa gctcgggttg gatgccgggg atgaatatga agatgaaaac     1800

ctttatgaag gcctgaacct ggacgactgc tccatgtatg aggacatctc ccggggcctc     1860

cagggcacct accaggatgt gggcagcctc aacataggag atgtccagct ggagaagccg     1920

tgactcgaga agcttaagtt taaacttact cacgtcatcc agcagagaat ggaaagtcaa     1980

atttcctgaa ttgctatgtg tctgggtttc atccatccga cattgaagtt gacttactga     2040

agaatggaga gagaattgaa aaagtggagc attcagactt gtctttcagc aaggactggt     2100

ctttctatct cttgtactac actgaattca cccccactga aaaagatgag tatgcctgcc     2160

gtgtgaacca tgtgactttg tcacagccca agatagttaa gtggggtaag tcttacattc     2220

ttttgtaagc tgctgaaagt tgtgtatgag tagtcatatc ataaagctgc tttgatataa     2280

aaaaggtcta tggccatact accctgaatg agtcccatcc catctgatat aaacaatctg     2340

catattggga ttgtcaggga atgttcttaa agatcagatt agtggcacct gctgagatac     2400

tgatgcacag catggtttct gaaccagtag tttccctgca gttgagcagg gagcagcagc     2460

agcacttgca caaatacata tacactctta acacttctta cctactggct tcctctagct     2520

tttgtggcag cttcaggtat atttagcact gaacgaacat ctcaagaagg tataggcctt     2580

tgtttgtaag tcctgctgtc ctagcatcct                                      2610


<210> 17
<211> 1899
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      polynucleotide

<400> 17
gctatgtccc aggcactcta ctagacactt catacagttt agaaaatcag atgggtgtag       60

atcaaggcag gagcaggaac caaaaagaaa ggcataaaca taagaaaaaa aatggaaggg      120

gtggaaacag agtacaataa catgagtaat ttgatggggg ctattatgaa ctgagaaatg      180

aactttgaaa agtatcttgg ggccaaatca tgtagactct tgagtgatgt gttaaggaat      240

gctatgagtg ctgagagggc atcagaagtc cttgagagcc tccagagaaa ggctcttaaa      300

aatgcagcgc aatctccagt gacagaagat actgctagaa atctgctaga aaaaaaacaa      360

aaaaggcatg tatagaggaa ttatgaggga aagataccaa gtcacggttt attcttcaaa      420

atggaggtgg cttgttggga aggtggaagc tcatttggcc agagtggaaa tggaattggg      480

agaaatcgat gaccaaatgt aaacacttgg tgcctgatat agcttgacac caagttagcc      540

ccaagtgaaa taccctggca atattaatgt gtcttttccc gatattcctc aggtactccc      600

tgcagggagg gcagaggaag tcttctaaca tgcggtgacg tggaggagaa tcccggccct      660

actagtgcca ccatgcactc ttcagctctt ttatgttgtc tcgttttgct cacaggcgtc      720

cgcgcctctc cgggtcaggg tacccagtct gaaaactctt gcacccattt tcccggaaat      780

ttacccaaca tgctgcgcga tttacgagac gcctttagcc gcgtaaagac cttctttcag      840

atgaaggacc aactggacaa cttgctgctg aaggaatctt tgcttgagga ttttaagggg      900

tatctcggct gccaggccct gtctgaaatg atccagttct acctcgagga ggtcatgcca      960

caggcagaga atcaggatcc agacattaaa gcacacgtga attctctggg cgagaatttg     1020

aaaaccctca ggctgcgcct gcggcgatgc cacagatttc ttccttgcga aaacaagtca     1080

aaagctgtcg agcaggtgaa aaatgccttc aacaaactcc aagaaaaggg gatatacaaa     1140

gccatgagcg agttcgatat attcattaat tacattgagg catacatgac aatgaaaatc     1200

agaaactaaa ggctaggtgg aggctcagtg aaacttactc acgtcatcca gcagagaatg     1260

gaaagtcaaa tttcctgaat tgctatgtgt ctgggtttca tccatccgac attgaagttg     1320

acttactgaa gaatggagag agaattgaaa aagtggagca ttcagacttg tctttcagca     1380

aggactggtc tttctatctc ttgtactaca ctgaattcac ccccactgaa aaagatgagt     1440

atgcctgccg tgtgaaccat gtgactttgt cacagcccaa gatagttaag tggggtaagt     1500

cttacattct tttgtaagct gctgaaagtt gtgtatgagt agtcatatca taaagctgct     1560

ttgatataaa aaaggtctat ggccatacta ccctgaatga gtcccatccc atctgatata     1620

aacaatctgc atattgggat tgtcagggaa tgttcttaaa gatcagatta gtggcacctg     1680

ctgagatact gatgcacagc atggtttctg aaccagtagt ttccctgcag ttgagcaggg     1740

agcagcagca gcacttgcac aaatacatat acactcttaa cacttcttac ctactggctt     1800

cctctagctt ttgtggcagc ttcaggtata tttagcactg aacgaacatc tcaagaaggt     1860

ataggccttt gtttgtaagt cctgctgtcc tagcatcct                            1899


<210> 18
<211> 1368
<212> PRT
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      polypeptide

<400> 18
Met Asp Lys Lys Tyr Ser Ile Gly Leu Asp Ile Gly Thr Asn Ser Val 
1               5                   10                  15      


Gly Trp Ala Val Ile Thr Asp Glu Tyr Lys Val Pro Ser Lys Lys Phe 
            20                  25                  30          


Lys Val Leu Gly Asn Thr Asp Arg His Ser Ile Lys Lys Asn Leu Ile 
        35                  40                  45              


Gly Ala Leu Leu Phe Asp Ser Gly Glu Thr Ala Glu Ala Thr Arg Leu 
    50                  55                  60                  


Lys Arg Thr Ala Arg Arg Arg Tyr Thr Arg Arg Lys Asn Arg Ile Cys 
65                  70                  75                  80  


Tyr Leu Gln Glu Ile Phe Ser Asn Glu Met Ala Lys Val Asp Asp Ser 
                85                  90                  95      


Phe Phe His Arg Leu Glu Glu Ser Phe Leu Val Glu Glu Asp Lys Lys 
            100                 105                 110         


His Glu Arg His Pro Ile Phe Gly Asn Ile Val Asp Glu Val Ala Tyr 
        115                 120                 125             


His Glu Lys Tyr Pro Thr Ile Tyr His Leu Arg Lys Lys Leu Val Asp 
    130                 135                 140                 


Ser Thr Asp Lys Ala Asp Leu Arg Leu Ile Tyr Leu Ala Leu Ala His 
145                 150                 155                 160 


Met Ile Lys Phe Arg Gly His Phe Leu Ile Glu Gly Asp Leu Asn Pro 
                165                 170                 175     


Asp Asn Ser Asp Val Asp Lys Leu Phe Ile Gln Leu Val Gln Thr Tyr 
            180                 185                 190         


Asn Gln Leu Phe Glu Glu Asn Pro Ile Asn Ala Ser Gly Val Asp Ala 
        195                 200                 205             


Lys Ala Ile Leu Ser Ala Arg Leu Ser Lys Ser Arg Arg Leu Glu Asn 
    210                 215                 220                 


Leu Ile Ala Gln Leu Pro Gly Glu Lys Lys Asn Gly Leu Phe Gly Asn 
225                 230                 235                 240 


Leu Ile Ala Leu Ser Leu Gly Leu Thr Pro Asn Phe Lys Ser Asn Phe 
                245                 250                 255     


Asp Leu Ala Glu Asp Ala Lys Leu Gln Leu Ser Lys Asp Thr Tyr Asp 
            260                 265                 270         


Asp Asp Leu Asp Asn Leu Leu Ala Gln Ile Gly Asp Gln Tyr Ala Asp 
        275                 280                 285             


Leu Phe Leu Ala Ala Lys Asn Leu Ser Asp Ala Ile Leu Leu Ser Asp 
    290                 295                 300                 


Ile Leu Arg Val Asn Thr Glu Ile Thr Lys Ala Pro Leu Ser Ala Ser 
305                 310                 315                 320 


Met Ile Lys Arg Tyr Asp Glu His His Gln Asp Leu Thr Leu Leu Lys 
                325                 330                 335     


Ala Leu Val Arg Gln Gln Leu Pro Glu Lys Tyr Lys Glu Ile Phe Phe 
            340                 345                 350         


Asp Gln Ser Lys Asn Gly Tyr Ala Gly Tyr Ile Asp Gly Gly Ala Ser 
        355                 360                 365             


Gln Glu Glu Phe Tyr Lys Phe Ile Lys Pro Ile Leu Glu Lys Met Asp 
    370                 375                 380                 


Gly Thr Glu Glu Leu Leu Val Lys Leu Asn Arg Glu Asp Leu Leu Arg 
385                 390                 395                 400 


Lys Gln Arg Thr Phe Asp Asn Gly Ser Ile Pro His Gln Ile His Leu 
                405                 410                 415     


Gly Glu Leu His Ala Ile Leu Arg Arg Gln Glu Asp Phe Tyr Pro Phe 
            420                 425                 430         


Leu Lys Asp Asn Arg Glu Lys Ile Glu Lys Ile Leu Thr Phe Arg Ile 
        435                 440                 445             


Pro Tyr Tyr Val Gly Pro Leu Ala Arg Gly Asn Ser Arg Phe Ala Trp 
    450                 455                 460                 


Met Thr Arg Lys Ser Glu Glu Thr Ile Thr Pro Trp Asn Phe Glu Glu 
465                 470                 475                 480 


Val Val Asp Lys Gly Ala Ser Ala Gln Ser Phe Ile Glu Arg Met Thr 
                485                 490                 495     


Asn Phe Asp Lys Asn Leu Pro Asn Glu Lys Val Leu Pro Lys His Ser 
            500                 505                 510         


Leu Leu Tyr Glu Tyr Phe Thr Val Tyr Asn Glu Leu Thr Lys Val Lys 
        515                 520                 525             


Tyr Val Thr Glu Gly Met Arg Lys Pro Ala Phe Leu Ser Gly Glu Gln 
    530                 535                 540                 


Lys Lys Ala Ile Val Asp Leu Leu Phe Lys Thr Asn Arg Lys Val Thr 
545                 550                 555                 560 


Val Lys Gln Leu Lys Glu Asp Tyr Phe Lys Lys Ile Glu Cys Phe Asp 
                565                 570                 575     


Ser Val Glu Ile Ser Gly Val Glu Asp Arg Phe Asn Ala Ser Leu Gly 
            580                 585                 590         


Thr Tyr His Asp Leu Leu Lys Ile Ile Lys Asp Lys Asp Phe Leu Asp 
        595                 600                 605             


Asn Glu Glu Asn Glu Asp Ile Leu Glu Asp Ile Val Leu Thr Leu Thr 
    610                 615                 620                 


Leu Phe Glu Asp Arg Glu Met Ile Glu Glu Arg Leu Lys Thr Tyr Ala 
625                 630                 635                 640 


His Leu Phe Asp Asp Lys Val Met Lys Gln Leu Lys Arg Arg Arg Tyr 
                645                 650                 655     


Thr Gly Trp Gly Arg Leu Ser Arg Lys Leu Ile Asn Gly Ile Arg Asp 
            660                 665                 670         


Lys Gln Ser Gly Lys Thr Ile Leu Asp Phe Leu Lys Ser Asp Gly Phe 
        675                 680                 685             


Ala Asn Arg Asn Phe Met Gln Leu Ile His Asp Asp Ser Leu Thr Phe 
    690                 695                 700                 


Lys Glu Asp Ile Gln Lys Ala Gln Val Ser Gly Gln Gly Asp Ser Leu 
705                 710                 715                 720 


His Glu His Ile Ala Asn Leu Ala Gly Ser Pro Ala Ile Lys Lys Gly 
                725                 730                 735     


Ile Leu Gln Thr Val Lys Val Val Asp Glu Leu Val Lys Val Met Gly 
            740                 745                 750         


Arg His Lys Pro Glu Asn Ile Val Ile Glu Met Ala Arg Glu Asn Gln 
        755                 760                 765             


Thr Thr Gln Lys Gly Gln Lys Asn Ser Arg Glu Arg Met Lys Arg Ile 
    770                 775                 780                 


Glu Glu Gly Ile Lys Glu Leu Gly Ser Gln Ile Leu Lys Glu His Pro 
785                 790                 795                 800 


Val Glu Asn Thr Gln Leu Gln Asn Glu Lys Leu Tyr Leu Tyr Tyr Leu 
                805                 810                 815     


Gln Asn Gly Arg Asp Met Tyr Val Asp Gln Glu Leu Asp Ile Asn Arg 
            820                 825                 830         


Leu Ser Asp Tyr Asp Val Asp His Ile Val Pro Gln Ser Phe Leu Lys 
        835                 840                 845             


Asp Asp Ser Ile Asp Asn Lys Val Leu Thr Arg Ser Asp Lys Asn Arg 
    850                 855                 860                 


Gly Lys Ser Asp Asn Val Pro Ser Glu Glu Val Val Lys Lys Met Lys 
865                 870                 875                 880 


Asn Tyr Trp Arg Gln Leu Leu Asn Ala Lys Leu Ile Thr Gln Arg Lys 
                885                 890                 895     


Phe Asp Asn Leu Thr Lys Ala Glu Arg Gly Gly Leu Ser Glu Leu Asp 
            900                 905                 910         


Lys Ala Gly Phe Ile Lys Arg Gln Leu Val Glu Thr Arg Gln Ile Thr 
        915                 920                 925             


Lys His Val Ala Gln Ile Leu Asp Ser Arg Met Asn Thr Lys Tyr Asp 
    930                 935                 940                 


Glu Asn Asp Lys Leu Ile Arg Glu Val Lys Val Ile Thr Leu Lys Ser 
945                 950                 955                 960 


Lys Leu Val Ser Asp Phe Arg Lys Asp Phe Gln Phe Tyr Lys Val Arg 
                965                 970                 975     


Glu Ile Asn Asn Tyr His His Ala His Asp Ala Tyr Leu Asn Ala Val 
            980                 985                 990         


Val Gly Thr Ala Leu Ile Lys Lys  Tyr Pro Lys Leu Glu  Ser Glu Phe 
        995                 1000                 1005             


Val Tyr  Gly Asp Tyr Lys Val  Tyr Asp Val Arg Lys  Met Ile Ala 
    1010                 1015                 1020             


Lys Ser  Glu Gln Glu Ile Gly  Lys Ala Thr Ala Lys  Tyr Phe Phe 
    1025                 1030                 1035             


Tyr Ser  Asn Ile Met Asn Phe  Phe Lys Thr Glu Ile  Thr Leu Ala 
    1040                 1045                 1050             


Asn Gly  Glu Ile Arg Lys Arg  Pro Leu Ile Glu Thr  Asn Gly Glu 
    1055                 1060                 1065             


Thr Gly  Glu Ile Val Trp Asp  Lys Gly Arg Asp Phe  Ala Thr Val 
    1070                 1075                 1080             


Arg Lys  Val Leu Ser Met Pro  Gln Val Asn Ile Val  Lys Lys Thr 
    1085                 1090                 1095             


Glu Val  Gln Thr Gly Gly Phe  Ser Lys Glu Ser Ile  Leu Pro Lys 
    1100                 1105                 1110             


Arg Asn  Ser Asp Lys Leu Ile  Ala Arg Lys Lys Asp  Trp Asp Pro 
    1115                 1120                 1125             


Lys Lys  Tyr Gly Gly Phe Asp  Ser Pro Thr Val Ala  Tyr Ser Val 
    1130                 1135                 1140             


Leu Val  Val Ala Lys Val Glu  Lys Gly Lys Ser Lys  Lys Leu Lys 
    1145                 1150                 1155             


Ser Val  Lys Glu Leu Leu Gly  Ile Thr Ile Met Glu  Arg Ser Ser 
    1160                 1165                 1170             


Phe Glu  Lys Asn Pro Ile Asp  Phe Leu Glu Ala Lys  Gly Tyr Lys 
    1175                 1180                 1185             


Glu Val  Lys Lys Asp Leu Ile  Ile Lys Leu Pro Lys  Tyr Ser Leu 
    1190                 1195                 1200             


Phe Glu  Leu Glu Asn Gly Arg  Lys Arg Met Leu Ala  Ser Ala Gly 
    1205                 1210                 1215             


Glu Leu  Gln Lys Gly Asn Glu  Leu Ala Leu Pro Ser  Lys Tyr Val 
    1220                 1225                 1230             


Asn Phe  Leu Tyr Leu Ala Ser  His Tyr Glu Lys Leu  Lys Gly Ser 
    1235                 1240                 1245             


Pro Glu  Asp Asn Glu Gln Lys  Gln Leu Phe Val Glu  Gln His Lys 
    1250                 1255                 1260             


His Tyr  Leu Asp Glu Ile Ile  Glu Gln Ile Ser Glu  Phe Ser Lys 
    1265                 1270                 1275             


Arg Val  Ile Leu Ala Asp Ala  Asn Leu Asp Lys Val  Leu Ser Ala 
    1280                 1285                 1290             


Tyr Asn  Lys His Arg Asp Lys  Pro Ile Arg Glu Gln  Ala Glu Asn 
    1295                 1300                 1305             


Ile Ile  His Leu Phe Thr Leu  Thr Asn Leu Gly Ala  Pro Ala Ala 
    1310                 1315                 1320             


Phe Lys  Tyr Phe Asp Thr Thr  Ile Asp Arg Lys Arg  Tyr Thr Ser 
    1325                 1330                 1335             


Thr Lys  Glu Val Leu Asp Ala  Thr Leu Ile His Gln  Ser Ile Thr 
    1340                 1345                 1350             


Gly Leu  Tyr Glu Thr Arg Ile  Asp Leu Ser Gln Leu  Gly Gly Asp 
    1355                 1360                 1365             


<210> 19
<211> 100
<212> RNA
<213> Homo sapiens


<220>
<221> misc_feature
<222> (1)..(4)
<223> modified with 2'-O-methyl phosphorothioate

<220>
<221> misc_feature
<222> (97)..(100)
<223> modified with 2'-O-methyl phosphorothioate

<400> 19
cgugaguaaa ccugaaucuu guuuuagagc uagaaauagc aaguuaaaau aaggcuaguc       60

cguuaucaac uugaaaaagu ggcaccgagu cggugcuuuu                            100


<210> 20
<211> 598
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      polynucleotide

<400> 20
gctatgtccc aggcactcta ctagacactt catacagttt agaaaatcag atgggtgtag       60

atcaaggcag gagcaggaac caaaaagaaa ggcataaaca taagaaaaaa aatggaaggg      120

gtggaaacag agtacaataa catgagtaat ttgatggggg ctattatgaa ctgagaaatg      180

aactttgaaa agtatcttgg ggccaaatca tgtagactct tgagtgatgt gttaaggaat      240

gctatgagtg ctgagagggc atcagaagtc cttgagagcc tccagagaaa ggctcttaaa      300

aatgcagcgc aatctccagt gacagaagat actgctagaa atctgctaga aaaaaaacaa      360

aaaaggcatg tatagaggaa ttatgaggga aagataccaa gtcacggttt attcttcaaa      420

atggaggtgg cttgttggga aggtggaagc tcatttggcc agagtggaaa tggaattggg      480

agaaatcgat gaccaaatgt aaacacttgg tgcctgatat agcttgacac caagttagcc      540

ccaagtgaaa taccctggca atattaatgt gtcttttccc gatattcctc aggtactc        598


<210> 21
<211> 665
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      polynucleotide

<400> 21
ttactcacgt catccagcag agaatggaaa gtcaaatttc ctgaattgct atgtgtctgg       60

gtttcatcca tccgacattg aagttgactt actgaagaat ggagagagaa ttgaaaaagt      120

ggagcattca gacttgtctt tcagcaagga ctggtctttc tatctcttgt actacactga      180

attcaccccc actgaaaaag atgagtatgc ctgccgtgtg aaccatgtga ctttgtcaca      240

gcccaagata gttaagtggg gtaagtctta cattcttttg taagctgctg aaagttgtgt      300

atgagtagtc atatcataaa gctgctttga tataaaaaag gtctatggcc atactaccct      360

gaatgagtcc catcccatct gatataaaca atctgcatat tgggattgtc agggaatgtt      420

cttaaagatc agattagtgg cacctgctga gatactgatg cacagcatgg tttctgaacc      480

agtagtttcc ctgcagttga gcagggagca gcagcagcac ttgcacaaat acatatacac      540

tcttaacact tcttacctac tggcttcctc tagcttttgt ggcagcttca ggtatattta      600

gcactgaacg aacatctcaa gaaggtatag gcctttgttt gtaagtcctg ctgtcctagc      660

atcct                                                                  665


<210> 22
<211> 360
<212> DNA
<213> Homo sapiens

<400> 22
atgtctcgct ccgtggcctt agctgtgctc gcgctactct ctctttctgg cctggaggct       60

atccagcgta ctccaaagat tcaggtttac tcacgtcatc cagcagagaa tggaaagtca      120

aatttcctga attgctatgt gtctgggttt catccatccg acattgaagt tgacttactg      180

aagaatggag agagaattga aaaagtggag cattcagact tgtctttcag caaggactgg      240

tctttctatc tcttgtacta cactgaattc acccccactg aaaaagatga gtatgcctgc      300

cgtgtgaacc atgtgacttt gtcacagccc aagatagtta agtgggatcg agacatgtaa      360


<210> 23
<211> 119
<212> PRT
<213> Homo sapiens

<400> 23
Met Ser Arg Ser Val Ala Leu Ala Val Leu Ala Leu Leu Ser Leu Ser 
1               5                   10                  15      


Gly Leu Glu Ala Ile Gln Arg Thr Pro Lys Ile Gln Val Tyr Ser Arg 
            20                  25                  30          


His Pro Ala Glu Asn Gly Lys Ser Asn Phe Leu Asn Cys Tyr Val Ser 
        35                  40                  45              


Gly Phe His Pro Ser Asp Ile Glu Val Asp Leu Leu Lys Asn Gly Glu 
    50                  55                  60                  


Arg Ile Glu Lys Val Glu His Ser Asp Leu Ser Phe Ser Lys Asp Trp 
65                  70                  75                  80  


Ser Phe Tyr Leu Leu Tyr Tyr Thr Glu Phe Thr Pro Thr Glu Lys Asp 
                85                  90                  95      


Glu Tyr Ala Cys Arg Val Asn His Val Thr Leu Ser Gln Pro Lys Ile 
            100                 105                 110         


Val Lys Trp Asp Arg Asp Met 
        115                 


<210> 24
<211> 23
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide

<400> 24
cgtgagtaaa cctgaatctt tgg                                               23


<210> 25
<211> 2079
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      polynucleotide

<400> 25
gctatgtccc aggcactcta ctagacactt catacagttt agaaaatcag atgggtgtag       60

atcaaggcag gagcaggaac caaaaagaaa ggcataaaca taagaaaaaa aatggaaggg      120

gtggaaacag agtacaataa catgagtaat ttgatggggg ctattatgaa ctgagaaatg      180

aactttgaaa agtatcttgg ggccaaatca tgtagactct tgagtgatgt gttaaggaat      240

gctatgagtg ctgagagggc atcagaagtc cttgagagcc tccagagaaa ggctcttaaa      300

aatgcagcgc aatctccagt gacagaagat actgctagaa atctgctaga aaaaaaacaa      360

aaaaggcatg tatagaggaa ttatgaggga aagataccaa gtcacggttt attcttcaaa      420

atggaggtgg cttgttggga aggtggaagc tcatttggcc agagtggaaa tggaattggg      480

agaaatcgat gaccaaatgt aaacacttgg tgcctgatat agcttgacac caagttagcc      540

ccaagtgaaa taccctggca atattaatgt gtcttttccc gatattcctc aggtactccc      600

tgcagggagg gcagaggaag tcttctaaca tgcggtgacg tggaggagaa tcccggccct      660

actagtgcca ccatggtgag caagggcgag gagctgttca ccggggtggt gcccatcctg      720

gtcgagctgg acggcgacgt aaacggccac aagttcagcg tgtccggcga gggcgagggc      780

gatgccacct acggcaagct gaccctgaag ttcatctgca ccaccggcaa gctgcccgtg      840

ccctggccca ccctcgtgac caccctgacc tacggcgtgc agtgcttcag ccgctacccc      900

gaccacatga agcagcacga cttcttcaag tccgccatgc ccgaaggcta cgtccaggag      960

cgcaccatct tcttcaagga cgacggcaac tacaagaccc gcgccgaggt gaagttcgag     1020

ggcgacaccc tggtgaaccg catcgagctg aagggcatcg acttcaagga ggacggcaac     1080

atcctggggc acaagctgga gtacaactac aacagccaca acgtctatat catggccgac     1140

aagcagaaga acggcatcaa ggtgaacttc aagatccgcc acaacatcga ggacggcagc     1200

gtgcagctcg ccgaccacta ccagcagaac acccccatcg gcgacggccc cgtgctgctg     1260

cccgacaacc actacctgag cacccagtcc gccctgagca aagaccccaa cgagaagcgc     1320

gatcacatgg tcctgctgga gttcgtgacc gccgccggga tcactctcgg catggacgag     1380

ctgtacaagt aactcgagaa gcttaagttt aaacttactc acgtcatcca gcagagaatg     1440

gaaagtcaaa tttcctgaat tgctatgtgt ctgggtttca tccatccgac attgaagttg     1500

acttactgaa gaatggagag agaattgaaa aagtggagca ttcagacttg tctttcagca     1560

aggactggtc tttctatctc ttgtactaca ctgaattcac ccccactgaa aaagatgagt     1620

atgcctgccg tgtgaaccat gtgactttgt cacagcccaa gatagttaag tggggtaagt     1680

cttacattct tttgtaagct gctgaaagtt gtgtatgagt agtcatatca taaagctgct     1740

ttgatataaa aaaggtctat ggccatacta ccctgaatga gtcccatccc atctgatata     1800

aacaatctgc atattgggat tgtcagggaa tgttcttaaa gatcagatta gtggcacctg     1860

ctgagatact gatgcacagc atggtttctg aaccagtagt ttccctgcag ttgagcaggg     1920

agcagcagca gcacttgcac aaatacatat acactcttaa cacttcttac ctactggctt     1980

cctctagctt ttgtggcagc ttcaggtata tttagcactg aacgaacatc tcaagaaggt     2040

ataggccttt gtttgtaagt cctgctgtcc tagcatcct                            2079


<210> 26
<211> 288
<212> PRT
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      polypeptide

<400> 26
Met Ser Arg Ser Val Ala Leu Ala Val Leu Ala Leu Leu Ser Leu Ser 
1               5                   10                  15      


Gly Leu Glu Ala Ile Gln Arg Thr Pro Cys Arg Glu Gly Arg Gly Ser 
            20                  25                  30          


Leu Leu Thr Cys Gly Asp Val Glu Glu Asn Pro Gly Pro Thr Ser Ala 
        35                  40                  45              


Thr Met Val Ser Lys Gly Glu Glu Leu Phe Thr Gly Val Val Pro Ile 
    50                  55                  60                  


Leu Val Glu Leu Asp Gly Asp Val Asn Gly His Lys Phe Ser Val Ser 
65                  70                  75                  80  


Gly Glu Gly Glu Gly Asp Ala Thr Tyr Gly Lys Leu Thr Leu Lys Phe 
                85                  90                  95      


Ile Cys Thr Thr Gly Lys Leu Pro Val Pro Trp Pro Thr Leu Val Thr 
            100                 105                 110         


Thr Leu Thr Tyr Gly Val Gln Cys Phe Ser Arg Tyr Pro Asp His Met 
        115                 120                 125             


Lys Gln His Asp Phe Phe Lys Ser Ala Met Pro Glu Gly Tyr Val Gln 
    130                 135                 140                 


Glu Arg Thr Ile Phe Phe Lys Asp Asp Gly Asn Tyr Lys Thr Arg Ala 
145                 150                 155                 160 


Glu Val Lys Phe Glu Gly Asp Thr Leu Val Asn Arg Ile Glu Leu Lys 
                165                 170                 175     


Gly Ile Asp Phe Lys Glu Asp Gly Asn Ile Leu Gly His Lys Leu Glu 
            180                 185                 190         


Tyr Asn Tyr Asn Ser His Asn Val Tyr Ile Met Ala Asp Lys Gln Lys 
        195                 200                 205             


Asn Gly Ile Lys Val Asn Phe Lys Ile Arg His Asn Ile Glu Asp Gly 
    210                 215                 220                 


Ser Val Gln Leu Ala Asp His Tyr Gln Gln Asn Thr Pro Ile Gly Asp 
225                 230                 235                 240 


Gly Pro Val Leu Leu Pro Asp Asn His Tyr Leu Ser Thr Gln Ser Ala 
                245                 250                 255     


Leu Ser Lys Asp Pro Asn Glu Lys Arg Asp His Met Val Leu Leu Glu 
            260                 265                 270         


Phe Val Thr Ala Ala Gly Ile Thr Leu Gly Met Asp Glu Leu Tyr Lys 
        275                 280                 285             


<210> 27
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide

<400> 27
tgagagggca tcagaagtcc                                                   20


<210> 28
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide

<400> 28
aagtcacatg gttcacacgg                                                   20


<210> 29
<211> 21
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide

<400> 29
gctatgtccc aggcactcta c                                                 21


<210> 30
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide

<400> 30
aggatgctag gacagcagga                                                   20


<210> 31
<211> 3677
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      polynucleotide

<400> 31
tgctttctct gacctgcatt ctctcccctg ggcctgtgcc gctttctgtc tgcagcttgt       60

ggcctgggtc acctctacgg ctggcccaga tccttccctg ccgcctcctt caggttccgt      120

cttcctccac tccctcttcc ccttgctctc tgctgtgttg ctgcccaagg atgctctttc      180

cggagcactt ccttctcggc gctgcaccac gtgatgtcct ctgagcggat cctccccgtg      240

tctgggtcct ctccgggcat ctctcctccc tcacccaacc ccatgccgtc ttcactcgct      300

gggttccctt ttccttctcc ttctggggcc tgtgccatct ctcgtttctt aggatggcct      360

tctccgacgg atgtctccct tgcgtcccgc ctccccttct tgtaggcctg catcatcacc      420

gtttttctgg acaaccccaa agtaccccgt ctccctggct ttagccacct ctccatcctc      480

ttgctttctt tgcctggaca ccccgttctc ctgtggattc gggtcacctc tcactccttt      540

catttgggca gctcccctac cccccttacc tctctagtct gtgctagctc ttccagcccc      600

ctgtcatggc atcttccagg ggtccgagag ctcagctagt cttcttcctc caacccgggc      660

ccctatgtcc acttcaggac agcatgtttg ctgcctccag ggatcctgtg tccccgagct      720

gggaccacct tatattccca gggccggtta atgtggctct ggttctgggt acttttatct      780

gtcccctcca ccccacagtg gggccctgca ggtgaaagac cccacctgta ggtttggcaa      840

gatagctgca gtaacgccat tttgcaaggc atggaaaaat accaaaccaa gaatagagaa      900

gttcagatca agggcgggta catgaaaata gctaacgttg ggccaaacag gatatctgcg      960

gtgagcagtt tcggccccgg cccggggcca agaacagatg gtcaccgcag tttcggcccc     1020

ggcccgaggc caagaacaga tggtccccag atatggccca accctcagca gtttcttaag     1080

acccatcaga tgtttccagg ctcccccaag gacctgaaat gaccctgcgc cttatttgaa     1140

ttaaccaatc agcctgcttc tcgcttctgt tcgcgcgctt ctgcttcccg agctctataa     1200

aagagctcac aacccctcac tcggcgcgcc agtcctccga ttgactgagt cgccctgatc     1260

agtactacta gtgccaccat gcagctgaga aacccagagt tgcatctggg atgcgccctg     1320

gcacttcgat ttctcgccct cgtatcttgg gacatccctg gcgcgcgcgc actggacaac     1380

ggactggcta ggacccccac catgggttgg ttacactggg aacggtttat gtgtaatctc     1440

gactgtcagg aagaaccgga ctcttgtatc tcagaaaaat tgtttatgga gatggcagaa     1500

ctgatggtgt cagaggggtg gaaagatgct gggtacgaat acctctgcat agatgactgt     1560

tggatggcgc cccagcgtga cagcgaggga cgcctgcagg ctgatcctca gagattccca     1620

catgggattc gacagctcgc taattacgtg cactcaaaag gcctgaaact ggggatctat     1680

gccgacgtcg ggaacaaaac ctgtgcagga ttccctggaa gtttcgggta ctacgacatc     1740

gacgcccaaa cctttgcaga ctggggcgtt gatctgctga agtttgacgg atgttattgt     1800

gacagcctgg agaaccttgc cgacggctat aagcatatga gcttggcatt gaaccgcacc     1860

ggacgaagca tagtgtactc ttgcgagtgg cctctctata tgtggccttt tcagaaacca     1920

aactacacgg aaatacggca atactgcaat cattggagga acttcgccga tattgacgat     1980

tcttggaaat ccatcaaaag catattagac tggaccagtt tcaatcagga aagaatcgtg     2040

gacgttgctg gtccaggagg ttggaacgat ccagacatgc tggtgattgg gaacttcggc     2100

ctcagttgga atcagcaggt cacacaaatg gcgctgtggg ctatcatggc tgcaccgctg     2160

tttatgtcaa acgacctgcg acacatcagc cctcaggcta aggcattgtt gcaagataag     2220

gatgtaatag caataaacca ggaccccctc ggtaagcagg gctatcagtt acgccagggc     2280

gataactttg aagtgtggga acgaccgttg tccggcctgg cctgggctgt ggccatgata     2340

aaccgacaag agattggagg gcccaggtct tatactatcg ctgtggcaag tcttggaaaa     2400

ggagtggctt gcaacccagc atgcttcatt actcagttgc tcccagtcaa aagaaagctc     2460

ggcttttacg agtggactag tcgacttcgg agtcatatta atccaaccgg caccgtctta     2520

cttcagctgg agaatacaat gcagatgtcc ctgaaggacc tcctctagag gctaggtgga     2580

ggctcagtgg tttaaaccgc tgatcactgt gccttctagt tgccagccat ctgttgtttg     2640

cccctccccc gtgccttcct tgaccctgga aggtgccact cccactgtcc tttcctaata     2700

aaatgaggaa attgcatcgc attgtctgag taggtgtcat tctattctgg ggggtggggt     2760

ggggcaggac agcaaggggg aggattggga agacaatagc aggcatgctg gggatgcggt     2820

gggctctatg ggcccgggca caggattggt gacagaaaag ccccatcctt aggcctcctc     2880

cttcctagtc tcctgatatt gggtctaacc cccacctcct gttaggcaga ttccttatct     2940

ggtgacacac ccccatttcc tggagccatc tctctccttg ccagaacctc taaggtttgc     3000

ttacgatgga gccagagagg atcctgggag ggagagcttg gcagggggtg ggagggaagg     3060

gggggatgcg tgacctgccc ggttctcagt ggccaccctg cgctaccctc tcccagaacc     3120

tgagctgctc tgacgcggcc gtctggtgcg tttcactgat cctggtgctg cagcttcctt     3180

acacttccca agaggagaag cagtttggaa aaacaaaatc agaataagtt ggtcctgagt     3240

tctaactttg gctcttcacc tttctagtcc ccaatttata ttgttcctcc gtgcgtcagt     3300

tttacctgtg agataaggcc agtagccagc cccgtcctgg cagggctgtg gtgaggaggg     3360

gggtgtccgt gtggaaaact ccctttgtga gaatggtgcg tcctaggtgt tcaccaggtc     3420

gtggccgcct ctactccctt tctctttctc catccttctt tccttaaaga gtccccagtg     3480

ctatctggga catattcctc cgcccagagc agggtcccgc ttccctaagg ccctgctctg     3540

ggcttctggg tttgagtcct tggcaagccc aggagaggcg ctcaggcttc cctgtccccc     3600

ttcctcgtcc accatctcat gcccctggct ctcctgcccc ttccctacag gggttcctgg     3660

ctctgctctg gccggcc                                                    3677


