                         SEQUENCE LISTING

<110>  Regeneron Pharmaceuticals, Inc.
       CROLL, Susan D.
       MACDONALD, Lynn
       MURPHY, Andrew J.
 
<120>  HUMAN ANTIBODIES TO ARTEMIN AND METHODS OF USE THEREOF

<130>  10907WO01

<140>  TBD
<141>  2022-04-19

<150>  63/177,369
<151>  2021-04-20

<160>  85    

<170>  PatentIn version 3.5

<210>  1
<211>  366
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Synthetic

<400>  1
gaggtgcagc tggtggagag cggcggcgac ctggtgcagc ccggcggcag cctgaagctg       60

agctgcgccg ccagcggctt caccttcagc ggcagcgcca tgcactgggt gaggcaggcc      120

agcggcaagg gcctggagtg ggtgggcagg atcaggaaca aggtgcacag gtacgccacc      180

gagtacggcg ccagcgtgaa gggcaggttc accatcagca gggacgacag caagaacacc      240

gcctacctgc agatgaacag cctgaagatc gaggacaccg ccgtgtacta ctgcgtggtg      300

gtggtgcccg gcagcatcga ggccttcgac atctggggcc agggcaccat ggtgaccgtg      360

agcagc                                                                 366


<210>  2
<211>  122
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic

<400>  2

Glu Val Gln Leu Val Glu Ser Gly Gly Asp Leu Val Gln Pro Gly Gly 
1               5                   10                  15      


Ser Leu Lys Leu Ser Cys Ala Ala Ser Gly Phe Thr Phe Ser Gly Ser 
            20                  25                  30          


Ala Met His Trp Val Arg Gln Ala Ser Gly Lys Gly Leu Glu Trp Val 
        35                  40                  45              


Gly Arg Ile Arg Asn Lys Val His Arg Tyr Ala Thr Glu Tyr Gly Ala 
    50                  55                  60                  


Ser Val Lys Gly Arg Phe Thr Ile Ser Arg Asp Asp Ser Lys Asn Thr 
65                  70                  75                  80  


Ala Tyr Leu Gln Met Asn Ser Leu Lys Ile Glu Asp Thr Ala Val Tyr 
                85                  90                  95      


Tyr Cys Val Val Val Val Pro Gly Ser Ile Glu Ala Phe Asp Ile Trp 
            100                 105                 110         


Gly Gln Gly Thr Met Val Thr Val Ser Ser 
        115                 120         


<210>  3
<211>  24
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Synthetic

<400>  3
ggcttcacct tcagcggcag cgcc                                              24


<210>  4
<211>  8
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic

<400>  4

Gly Phe Thr Phe Ser Gly Ser Ala 
1               5               


<210>  5
<211>  30
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Synthetic

<400>  5
atcaggaaca aggtgcacag gtacgccacc                                        30


<210>  6
<211>  10
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic

<400>  6

Ile Arg Asn Lys Val His Arg Tyr Ala Thr 
1               5                   10  


<210>  7
<211>  39
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Synthetic

<400>  7
gtggtggtgg tgcccggcag catcgaggcc ttcgacatc                              39


<210>  8
<211>  13
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic

<400>  8

Val Val Val Val Pro Gly Ser Ile Glu Ala Phe Asp Ile 
1               5                   10              


<210>  9
<211>  321
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Synthetic

<400>  9
gacatccaga tgacccagag ccccagcagc ctgagcgcca gcgtgggcga cagggtgacc       60

atcacctgca gggccagcca gagcatcagc acctacctga actggtacca gcagaagccc      120

ggcaaggccc ccaacctgct gatctacgcc gccagcaccc tggagagcgg cgtgcccagc      180

aggttcagcg gcagcggcag cggcaccgac ttcaccctga ccatcagcag cctgcagccc      240

gaggacttcg agatctacta ctgccagcag agctacaaca tcccctggac cttcggccag      300

ggcaccaagg tggagatcaa g                                                321


<210>  10
<211>  107
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic

<400>  10

Asp Ile Gln Met Thr Gln Ser Pro Ser Ser Leu Ser Ala Ser Val Gly 
1               5                   10                  15      


Asp Arg Val Thr Ile Thr Cys Arg Ala Ser Gln Ser Ile Ser Thr Tyr 
            20                  25                  30          


Leu Asn Trp Tyr Gln Gln Lys Pro Gly Lys Ala Pro Asn Leu Leu Ile 
        35                  40                  45              


Tyr Ala Ala Ser Thr Leu Glu Ser Gly Val Pro Ser Arg Phe Ser Gly 
    50                  55                  60                  


Ser Gly Ser Gly Thr Asp Phe Thr Leu Thr Ile Ser Ser Leu Gln Pro 
65                  70                  75                  80  


Glu Asp Phe Glu Ile Tyr Tyr Cys Gln Gln Ser Tyr Asn Ile Pro Trp 
                85                  90                  95      


Thr Phe Gly Gln Gly Thr Lys Val Glu Ile Lys 
            100                 105         


<210>  11
<211>  18
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Synthetic

<400>  11
cagagcatca gcacctac                                                     18


<210>  12
<211>  6
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic

<400>  12

Gln Ser Ile Ser Thr Tyr 
1               5       


<210>  13
<211>  9
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Synthetic

<400>  13
gccgccagc                                                                9


<210>  14
<211>  3
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic

<400>  14

Ala Ala Ser 
1           


<210>  15
<211>  27
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Synthetic

<400>  15
cagcagagct acaacatccc ctggacc                                           27


<210>  16
<211>  9
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic

<400>  16

Gln Gln Ser Tyr Asn Ile Pro Trp Thr 
1               5                   


<210>  17
<211>  1347
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Synthetic

<400>  17
gaggtgcagc tggtggagag cggcggcgac ctggtgcagc ccggcggcag cctgaagctg       60

agctgcgccg ccagcggctt caccttcagc ggcagcgcca tgcactgggt gaggcaggcc      120

agcggcaagg gcctggagtg ggtgggcagg atcaggaaca aggtgcacag gtacgccacc      180

gagtacggcg ccagcgtgaa gggcaggttc accatcagca gggacgacag caagaacacc      240

gcctacctgc agatgaacag cctgaagatc gaggacaccg ccgtgtacta ctgcgtggtg      300

gtggtgcccg gcagcatcga ggccttcgac atctggggcc agggcaccat ggtgaccgtg      360

agcagcgcca gcaccaaggg ccccagcgtg ttccccctgg ccccctgcag caggagcacc      420

agcgagagca ccgccgccct gggctgcctg gtgaaggact acttccccga gcccgtgacc      480

gtgagctgga acagcggcgc cctgaccagc ggcgtgcaca ccttccccgc cgtgctgcag      540

agcagcggcc tgtacagcct gagcagcgtg gtgaccgtgc ccagcagcag cctgggcacc      600

aagacctaca cctgcaacgt ggaccacaag cccagcaaca ccaaggtgga caagagggtg      660

gagagcaagt acggcccccc ctgccccccc tgccccgccc ccgagttcct gggcggcccc      720

agcgtgttcc tgttcccccc caagcccaag gacaccctga tgatcagcag gacccccgag      780

gtgacctgcg tggtggtgga cgtgagccag gaggaccccg aggtgcagtt caactggtac      840

gtggacggcg tggaggtgca caacgccaag accaagccca gggaggagca gttcaacagc      900

acctacaggg tggtgagcgt gctgaccgtg ctgcaccagg actggctgaa cggcaaggag      960

tacaagtgca aggtgagcaa caagggcctg cccagcagca tcgagaagac catcagcaag     1020

gccaagggcc agcccaggga gccccaggtg tacaccctgc cccccagcca ggaggagatg     1080

accaagaacc aggtgagcct gacctgcctg gtgaagggct tctaccccag cgacatcgcc     1140

gtggagtggg agagcaacgg ccagcccgag aacaactaca agaccacccc ccccgtgctg     1200

gacagcgacg gcagcttctt cctgtacagc aggctgaccg tggacaagag caggtggcag     1260

gagggcaacg tgttcagctg cagcgtgatg cacgaggccc tgcacaacca ctacacccag     1320

aagagcctga gcctgagcct gggcaag                                         1347


<210>  18
<211>  449
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic

<400>  18

Glu Val Gln Leu Val Glu Ser Gly Gly Asp Leu Val Gln Pro Gly Gly 
1               5                   10                  15      


Ser Leu Lys Leu Ser Cys Ala Ala Ser Gly Phe Thr Phe Ser Gly Ser 
            20                  25                  30          


Ala Met His Trp Val Arg Gln Ala Ser Gly Lys Gly Leu Glu Trp Val 
        35                  40                  45              


Gly Arg Ile Arg Asn Lys Val His Arg Tyr Ala Thr Glu Tyr Gly Ala 
    50                  55                  60                  


Ser Val Lys Gly Arg Phe Thr Ile Ser Arg Asp Asp Ser Lys Asn Thr 
65                  70                  75                  80  


Ala Tyr Leu Gln Met Asn Ser Leu Lys Ile Glu Asp Thr Ala Val Tyr 
                85                  90                  95      


Tyr Cys Val Val Val Val Pro Gly Ser Ile Glu Ala Phe Asp Ile Trp 
            100                 105                 110         


Gly Gln Gly Thr Met Val Thr Val Ser Ser Ala Ser Thr Lys Gly Pro 
        115                 120                 125             


Ser Val Phe Pro Leu Ala Pro Cys Ser Arg Ser Thr Ser Glu Ser Thr 
    130                 135                 140                 


Ala Ala Leu Gly Cys Leu Val Lys Asp Tyr Phe Pro Glu Pro Val Thr 
145                 150                 155                 160 


Val Ser Trp Asn Ser Gly Ala Leu Thr Ser Gly Val His Thr Phe Pro 
                165                 170                 175     


Ala Val Leu Gln Ser Ser Gly Leu Tyr Ser Leu Ser Ser Val Val Thr 
            180                 185                 190         


Val Pro Ser Ser Ser Leu Gly Thr Lys Thr Tyr Thr Cys Asn Val Asp 
        195                 200                 205             


His Lys Pro Ser Asn Thr Lys Val Asp Lys Arg Val Glu Ser Lys Tyr 
    210                 215                 220                 


Gly Pro Pro Cys Pro Pro Cys Pro Ala Pro Glu Phe Leu Gly Gly Pro 
225                 230                 235                 240 


Ser Val Phe Leu Phe Pro Pro Lys Pro Lys Asp Thr Leu Met Ile Ser 
                245                 250                 255     


Arg Thr Pro Glu Val Thr Cys Val Val Val Asp Val Ser Gln Glu Asp 
            260                 265                 270         


Pro Glu Val Gln Phe Asn Trp Tyr Val Asp Gly Val Glu Val His Asn 
        275                 280                 285             


Ala Lys Thr Lys Pro Arg Glu Glu Gln Phe Asn Ser Thr Tyr Arg Val 
    290                 295                 300                 


Val Ser Val Leu Thr Val Leu His Gln Asp Trp Leu Asn Gly Lys Glu 
305                 310                 315                 320 


Tyr Lys Cys Lys Val Ser Asn Lys Gly Leu Pro Ser Ser Ile Glu Lys 
                325                 330                 335     


Thr Ile Ser Lys Ala Lys Gly Gln Pro Arg Glu Pro Gln Val Tyr Thr 
            340                 345                 350         


Leu Pro Pro Ser Gln Glu Glu Met Thr Lys Asn Gln Val Ser Leu Thr 
        355                 360                 365             


Cys Leu Val Lys Gly Phe Tyr Pro Ser Asp Ile Ala Val Glu Trp Glu 
    370                 375                 380                 


Ser Asn Gly Gln Pro Glu Asn Asn Tyr Lys Thr Thr Pro Pro Val Leu 
385                 390                 395                 400 


Asp Ser Asp Gly Ser Phe Phe Leu Tyr Ser Arg Leu Thr Val Asp Lys 
                405                 410                 415     


Ser Arg Trp Gln Glu Gly Asn Val Phe Ser Cys Ser Val Met His Glu 
            420                 425                 430         


Ala Leu His Asn His Tyr Thr Gln Lys Ser Leu Ser Leu Ser Leu Gly 
        435                 440                 445             


Lys 
    


<210>  19
<211>  642
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Synthetic

<400>  19
gacatccaga tgacccagag ccccagcagc ctgagcgcca gcgtgggcga cagggtgacc       60

atcacctgca gggccagcca gagcatcagc acctacctga actggtacca gcagaagccc      120

ggcaaggccc ccaacctgct gatctacgcc gccagcaccc tggagagcgg cgtgcccagc      180

aggttcagcg gcagcggcag cggcaccgac ttcaccctga ccatcagcag cctgcagccc      240

gaggacttcg agatctacta ctgccagcag agctacaaca tcccctggac cttcggccag      300

ggcaccaagg tggagatcaa gaggaccgtg gccgccccca gcgtgttcat cttccccccc      360

agcgacgagc agctgaagag cggcaccgcc agcgtggtgt gcctgctgaa caacttctac      420

cccagggagg ccaaggtgca gtggaaggtg gacaacgccc tgcagagcgg caacagccag      480

gagagcgtga ccgagcagga cagcaaggac agcacctaca gcctgagcag caccctgacc      540

ctgagcaagg ccgactacga gaagcacaag gtgtacgcct gcgaggtgac ccaccagggc      600

ctgagcagcc ccgtgaccaa gagcttcaac aggggcgagt gc                         642


<210>  20
<211>  214
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic

<400>  20

Asp Ile Gln Met Thr Gln Ser Pro Ser Ser Leu Ser Ala Ser Val Gly 
1               5                   10                  15      


Asp Arg Val Thr Ile Thr Cys Arg Ala Ser Gln Ser Ile Ser Thr Tyr 
            20                  25                  30          


Leu Asn Trp Tyr Gln Gln Lys Pro Gly Lys Ala Pro Asn Leu Leu Ile 
        35                  40                  45              


Tyr Ala Ala Ser Thr Leu Glu Ser Gly Val Pro Ser Arg Phe Ser Gly 
    50                  55                  60                  


Ser Gly Ser Gly Thr Asp Phe Thr Leu Thr Ile Ser Ser Leu Gln Pro 
65                  70                  75                  80  


Glu Asp Phe Glu Ile Tyr Tyr Cys Gln Gln Ser Tyr Asn Ile Pro Trp 
                85                  90                  95      


Thr Phe Gly Gln Gly Thr Lys Val Glu Ile Lys Arg Thr Val Ala Ala 
            100                 105                 110         


Pro Ser Val Phe Ile Phe Pro Pro Ser Asp Glu Gln Leu Lys Ser Gly 
        115                 120                 125             


Thr Ala Ser Val Val Cys Leu Leu Asn Asn Phe Tyr Pro Arg Glu Ala 
    130                 135                 140                 


Lys Val Gln Trp Lys Val Asp Asn Ala Leu Gln Ser Gly Asn Ser Gln 
145                 150                 155                 160 


Glu Ser Val Thr Glu Gln Asp Ser Lys Asp Ser Thr Tyr Ser Leu Ser 
                165                 170                 175     


Ser Thr Leu Thr Leu Ser Lys Ala Asp Tyr Glu Lys His Lys Val Tyr 
            180                 185                 190         


Ala Cys Glu Val Thr His Gln Gly Leu Ser Ser Pro Val Thr Lys Ser 
        195                 200                 205             


Phe Asn Arg Gly Glu Cys 
    210                 


<210>  21
<211>  360
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Synthetic

<400>  21
gaggtgcagc tggtggagag cggcggcggc ctggtgcagc ccggcggcag cctgaggctg       60

agctgcgccg ccagcggctt caccttcagc agctacgaca tgcactgggt gaggcaggcc      120

accggcaagg gcctggagtg ggtgagcacc atcgacaccg ccggcgacac ctactacccc      180

ggcagcgtga agggcaggtt caccatcagc agggagaacg ccaagaacag cctgtacctg      240

cagatgaaca gcctgagggc cggcgacacc gccgtgtact actgcgccag ggacggcgag      300

ctggagctgc agggctactt cgacctgtgg ggcaggggca ccctggtgac cgtgagcagc      360


<210>  22
<211>  120
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic

<400>  22

Glu Val Gln Leu Val Glu Ser Gly Gly Gly Leu Val Gln Pro Gly Gly 
1               5                   10                  15      


Ser Leu Arg Leu Ser Cys Ala Ala Ser Gly Phe Thr Phe Ser Ser Tyr 
            20                  25                  30          


Asp Met His Trp Val Arg Gln Ala Thr Gly Lys Gly Leu Glu Trp Val 
        35                  40                  45              


Ser Thr Ile Asp Thr Ala Gly Asp Thr Tyr Tyr Pro Gly Ser Val Lys 
    50                  55                  60                  


Gly Arg Phe Thr Ile Ser Arg Glu Asn Ala Lys Asn Ser Leu Tyr Leu 
65                  70                  75                  80  


Gln Met Asn Ser Leu Arg Ala Gly Asp Thr Ala Val Tyr Tyr Cys Ala 
                85                  90                  95      


Arg Asp Gly Glu Leu Glu Leu Gln Gly Tyr Phe Asp Leu Trp Gly Arg 
            100                 105                 110         


Gly Thr Leu Val Thr Val Ser Ser 
        115                 120 


<210>  23
<211>  24
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Synthetic

<400>  23
ggcttcacct tcagcagcta cgac                                              24


<210>  24
<211>  8
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic

<400>  24

Gly Phe Thr Phe Ser Ser Tyr Asp 
1               5               


<210>  25
<211>  21
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Synthetic

<400>  25
atcgacaccg ccggcgacac c                                                 21


<210>  26
<211>  7
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic

<400>  26

Ile Asp Thr Ala Gly Asp Thr 
1               5           


<210>  27
<211>  42
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Synthetic

<400>  27
gccagggacg gcgagctgga gctgcagggc tacttcgacc tg                          42


<210>  28
<211>  14
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic

<400>  28

Ala Arg Asp Gly Glu Leu Glu Leu Gln Gly Tyr Phe Asp Leu 
1               5                   10                  


<210>  29
<211>  321
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Synthetic

<400>  29
gacatccaga tgacccagag ccccagcagc ctgagcgcca gcgtgggcga cagggtgacc       60

atcacctgca gggccagcca gatcatcagc atctacctga actggtacca gcagaagccc      120

ggcaaggccc ccaagctgct gatctacgcc gccagcagcc tgcagagcgg cgtgcccagc      180

aggttcagcg gcagcggcag cggcaccgac ttcaccctga ccatcagcag cctgcagccc      240

gaggacttcg ccacctacta ctgccagcag agctacacca cccccctgac cttcggcggc      300

ggcaccaagg tggagatcaa g                                                321


<210>  30
<211>  107
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic

<400>  30

Asp Ile Gln Met Thr Gln Ser Pro Ser Ser Leu Ser Ala Ser Val Gly 
1               5                   10                  15      


Asp Arg Val Thr Ile Thr Cys Arg Ala Ser Gln Ile Ile Ser Ile Tyr 
            20                  25                  30          


Leu Asn Trp Tyr Gln Gln Lys Pro Gly Lys Ala Pro Lys Leu Leu Ile 
        35                  40                  45              


Tyr Ala Ala Ser Ser Leu Gln Ser Gly Val Pro Ser Arg Phe Ser Gly 
    50                  55                  60                  


Ser Gly Ser Gly Thr Asp Phe Thr Leu Thr Ile Ser Ser Leu Gln Pro 
65                  70                  75                  80  


Glu Asp Phe Ala Thr Tyr Tyr Cys Gln Gln Ser Tyr Thr Thr Pro Leu 
                85                  90                  95      


Thr Phe Gly Gly Gly Thr Lys Val Glu Ile Lys 
            100                 105         


<210>  31
<211>  18
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Synthetic

<400>  31
cagatcatca gcatctac                                                     18


<210>  32
<211>  6
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic

<400>  32

Gln Ile Ile Ser Ile Tyr 
1               5       


<210>  33
<211>  9
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Synthetic

<400>  33
gccgccagc                                                                9


<210>  34
<211>  3
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic

<400>  34

Ala Ala Ser 
1           


<210>  35
<211>  27
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Synthetic

<400>  35
cagcagagct acaccacccc cctgacc                                           27


<210>  36
<211>  9
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic

<400>  36

Gln Gln Ser Tyr Thr Thr Pro Leu Thr 
1               5                   


<210>  37
<211>  1341
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Synthetic

<400>  37
gaggtgcagc tggtggagag cggcggcggc ctggtgcagc ccggcggcag cctgaggctg       60

agctgcgccg ccagcggctt caccttcagc agctacgaca tgcactgggt gaggcaggcc      120

accggcaagg gcctggagtg ggtgagcacc atcgacaccg ccggcgacac ctactacccc      180

ggcagcgtga agggcaggtt caccatcagc agggagaacg ccaagaacag cctgtacctg      240

cagatgaaca gcctgagggc cggcgacacc gccgtgtact actgcgccag ggacggcgag      300

ctggagctgc agggctactt cgacctgtgg ggcaggggca ccctggtgac cgtgagcagc      360

gccagcacca agggccccag cgtgttcccc ctggccccct gcagcaggag caccagcgag      420

agcaccgccg ccctgggctg cctggtgaag gactacttcc ccgagcccgt gaccgtgagc      480

tggaacagcg gcgccctgac cagcggcgtg cacaccttcc ccgccgtgct gcagagcagc      540

ggcctgtaca gcctgagcag cgtggtgacc gtgcccagca gcagcctggg caccaagacc      600

tacacctgca acgtggacca caagcccagc aacaccaagg tggacaagag ggtggagagc      660

aagtacggcc ccccctgccc cccctgcccc gcccccgagt tcctgggcgg ccccagcgtg      720

ttcctgttcc cccccaagcc caaggacacc ctgatgatca gcaggacccc cgaggtgacc      780

tgcgtggtgg tggacgtgag ccaggaggac cccgaggtgc agttcaactg gtacgtggac      840

ggcgtggagg tgcacaacgc caagaccaag cccagggagg agcagttcaa cagcacctac      900

agggtggtga gcgtgctgac cgtgctgcac caggactggc tgaacggcaa ggagtacaag      960

tgcaaggtga gcaacaaggg cctgcccagc agcatcgaga agaccatcag caaggccaag     1020

ggccagccca gggagcccca ggtgtacacc ctgcccccca gccaggagga gatgaccaag     1080

aaccaggtga gcctgacctg cctggtgaag ggcttctacc ccagcgacat cgccgtggag     1140

tgggagagca acggccagcc cgagaacaac tacaagacca ccccccccgt gctggacagc     1200

gacggcagct tcttcctgta cagcaggctg accgtggaca agagcaggtg gcaggagggc     1260

aacgtgttca gctgcagcgt gatgcacgag gccctgcaca accactacac ccagaagagc     1320

ctgagcctga gcctgggcaa g                                               1341


<210>  38
<211>  447
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic

<400>  38

Glu Val Gln Leu Val Glu Ser Gly Gly Gly Leu Val Gln Pro Gly Gly 
1               5                   10                  15      


Ser Leu Arg Leu Ser Cys Ala Ala Ser Gly Phe Thr Phe Ser Ser Tyr 
            20                  25                  30          


Asp Met His Trp Val Arg Gln Ala Thr Gly Lys Gly Leu Glu Trp Val 
        35                  40                  45              


Ser Thr Ile Asp Thr Ala Gly Asp Thr Tyr Tyr Pro Gly Ser Val Lys 
    50                  55                  60                  


Gly Arg Phe Thr Ile Ser Arg Glu Asn Ala Lys Asn Ser Leu Tyr Leu 
65                  70                  75                  80  


Gln Met Asn Ser Leu Arg Ala Gly Asp Thr Ala Val Tyr Tyr Cys Ala 
                85                  90                  95      


Arg Asp Gly Glu Leu Glu Leu Gln Gly Tyr Phe Asp Leu Trp Gly Arg 
            100                 105                 110         


Gly Thr Leu Val Thr Val Ser Ser Ala Ser Thr Lys Gly Pro Ser Val 
        115                 120                 125             


Phe Pro Leu Ala Pro Cys Ser Arg Ser Thr Ser Glu Ser Thr Ala Ala 
    130                 135                 140                 


Leu Gly Cys Leu Val Lys Asp Tyr Phe Pro Glu Pro Val Thr Val Ser 
145                 150                 155                 160 


Trp Asn Ser Gly Ala Leu Thr Ser Gly Val His Thr Phe Pro Ala Val 
                165                 170                 175     


Leu Gln Ser Ser Gly Leu Tyr Ser Leu Ser Ser Val Val Thr Val Pro 
            180                 185                 190         


Ser Ser Ser Leu Gly Thr Lys Thr Tyr Thr Cys Asn Val Asp His Lys 
        195                 200                 205             


Pro Ser Asn Thr Lys Val Asp Lys Arg Val Glu Ser Lys Tyr Gly Pro 
    210                 215                 220                 


Pro Cys Pro Pro Cys Pro Ala Pro Glu Phe Leu Gly Gly Pro Ser Val 
225                 230                 235                 240 


Phe Leu Phe Pro Pro Lys Pro Lys Asp Thr Leu Met Ile Ser Arg Thr 
                245                 250                 255     


Pro Glu Val Thr Cys Val Val Val Asp Val Ser Gln Glu Asp Pro Glu 
            260                 265                 270         


Val Gln Phe Asn Trp Tyr Val Asp Gly Val Glu Val His Asn Ala Lys 
        275                 280                 285             


Thr Lys Pro Arg Glu Glu Gln Phe Asn Ser Thr Tyr Arg Val Val Ser 
    290                 295                 300                 


Val Leu Thr Val Leu His Gln Asp Trp Leu Asn Gly Lys Glu Tyr Lys 
305                 310                 315                 320 


Cys Lys Val Ser Asn Lys Gly Leu Pro Ser Ser Ile Glu Lys Thr Ile 
                325                 330                 335     


Ser Lys Ala Lys Gly Gln Pro Arg Glu Pro Gln Val Tyr Thr Leu Pro 
            340                 345                 350         


Pro Ser Gln Glu Glu Met Thr Lys Asn Gln Val Ser Leu Thr Cys Leu 
        355                 360                 365             


Val Lys Gly Phe Tyr Pro Ser Asp Ile Ala Val Glu Trp Glu Ser Asn 
    370                 375                 380                 


Gly Gln Pro Glu Asn Asn Tyr Lys Thr Thr Pro Pro Val Leu Asp Ser 
385                 390                 395                 400 


Asp Gly Ser Phe Phe Leu Tyr Ser Arg Leu Thr Val Asp Lys Ser Arg 
                405                 410                 415     


Trp Gln Glu Gly Asn Val Phe Ser Cys Ser Val Met His Glu Ala Leu 
            420                 425                 430         


His Asn His Tyr Thr Gln Lys Ser Leu Ser Leu Ser Leu Gly Lys 
        435                 440                 445         


<210>  39
<211>  642
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Synthetic

<400>  39
gacatccaga tgacccagag ccccagcagc ctgagcgcca gcgtgggcga cagggtgacc       60

atcacctgca gggccagcca gatcatcagc atctacctga actggtacca gcagaagccc      120

ggcaaggccc ccaagctgct gatctacgcc gccagcagcc tgcagagcgg cgtgcccagc      180

aggttcagcg gcagcggcag cggcaccgac ttcaccctga ccatcagcag cctgcagccc      240

gaggacttcg ccacctacta ctgccagcag agctacacca cccccctgac cttcggcggc      300

ggcaccaagg tggagatcaa gaggaccgtg gccgccccca gcgtgttcat cttccccccc      360

agcgacgagc agctgaagag cggcaccgcc agcgtggtgt gcctgctgaa caacttctac      420

cccagggagg ccaaggtgca gtggaaggtg gacaacgccc tgcagagcgg caacagccag      480

gagagcgtga ccgagcagga cagcaaggac agcacctaca gcctgagcag caccctgacc      540

ctgagcaagg ccgactacga gaagcacaag gtgtacgcct gcgaggtgac ccaccagggc      600

ctgagcagcc ccgtgaccaa gagcttcaac aggggcgagt gc                         642


<210>  40
<211>  214
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic

<400>  40

Asp Ile Gln Met Thr Gln Ser Pro Ser Ser Leu Ser Ala Ser Val Gly 
1               5                   10                  15      


Asp Arg Val Thr Ile Thr Cys Arg Ala Ser Gln Ile Ile Ser Ile Tyr 
            20                  25                  30          


Leu Asn Trp Tyr Gln Gln Lys Pro Gly Lys Ala Pro Lys Leu Leu Ile 
        35                  40                  45              


Tyr Ala Ala Ser Ser Leu Gln Ser Gly Val Pro Ser Arg Phe Ser Gly 
    50                  55                  60                  


Ser Gly Ser Gly Thr Asp Phe Thr Leu Thr Ile Ser Ser Leu Gln Pro 
65                  70                  75                  80  


Glu Asp Phe Ala Thr Tyr Tyr Cys Gln Gln Ser Tyr Thr Thr Pro Leu 
                85                  90                  95      


Thr Phe Gly Gly Gly Thr Lys Val Glu Ile Lys Arg Thr Val Ala Ala 
            100                 105                 110         


Pro Ser Val Phe Ile Phe Pro Pro Ser Asp Glu Gln Leu Lys Ser Gly 
        115                 120                 125             


Thr Ala Ser Val Val Cys Leu Leu Asn Asn Phe Tyr Pro Arg Glu Ala 
    130                 135                 140                 


Lys Val Gln Trp Lys Val Asp Asn Ala Leu Gln Ser Gly Asn Ser Gln 
145                 150                 155                 160 


Glu Ser Val Thr Glu Gln Asp Ser Lys Asp Ser Thr Tyr Ser Leu Ser 
                165                 170                 175     


Ser Thr Leu Thr Leu Ser Lys Ala Asp Tyr Glu Lys His Lys Val Tyr 
            180                 185                 190         


Ala Cys Glu Val Thr His Gln Gly Leu Ser Ser Pro Val Thr Lys Ser 
        195                 200                 205             


Phe Asn Arg Gly Glu Cys 
    210                 


<210>  41
<211>  372
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Synthetic

<400>  41
caggtgcagc tggtggagag cggcggcggc gtggtgcagc ccggcaggag cctgaggctg       60

agctgcgtgg ccagcggctt catcctgagc cactacggca tgcactgggt gaggcaggcc      120

cccggcaagg gcctggagtg ggtggccgtg atctggttcg acggcaccaa caagtactac      180

gccgacagcg tgaagggcag gttcaccgtg agcagggaca acagcaagaa caccctgtac      240

atgcagatga acagcctgag ggccgaggac accgccgtgt actactgcgc cagggacccc      300

ccccccgcca ggaggggcaa ctacaacggc atggacgtgt ggggccaggg caccaccgtg      360

accgtgagca gc                                                          372


<210>  42
<211>  124
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic

<400>  42

Gln Val Gln Leu Val Glu Ser Gly Gly Gly Val Val Gln Pro Gly Arg 
1               5                   10                  15      


Ser Leu Arg Leu Ser Cys Val Ala Ser Gly Phe Ile Leu Ser His Tyr 
            20                  25                  30          


Gly Met His Trp Val Arg Gln Ala Pro Gly Lys Gly Leu Glu Trp Val 
        35                  40                  45              


Ala Val Ile Trp Phe Asp Gly Thr Asn Lys Tyr Tyr Ala Asp Ser Val 
    50                  55                  60                  


Lys Gly Arg Phe Thr Val Ser Arg Asp Asn Ser Lys Asn Thr Leu Tyr 
65                  70                  75                  80  


Met Gln Met Asn Ser Leu Arg Ala Glu Asp Thr Ala Val Tyr Tyr Cys 
                85                  90                  95      


Ala Arg Asp Pro Pro Pro Ala Arg Arg Gly Asn Tyr Asn Gly Met Asp 
            100                 105                 110         


Val Trp Gly Gln Gly Thr Thr Val Thr Val Ser Ser 
        115                 120                 


<210>  43
<211>  24
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Synthetic

<400>  43
ggcttcatcc tgagccacta cggc                                              24


<210>  44
<211>  8
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic

<400>  44

Gly Phe Ile Leu Ser His Tyr Gly 
1               5               


<210>  45
<211>  24
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Synthetic

<400>  45
atctggttcg acggcaccaa caag                                              24


<210>  46
<211>  8
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic

<400>  46

Ile Trp Phe Asp Gly Thr Asn Lys 
1               5               


<210>  47
<211>  51
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Synthetic

<400>  47
gccagggacc ccccccccgc caggaggggc aactacaacg gcatggacgt g                51


<210>  48
<211>  17
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic

<400>  48

Ala Arg Asp Pro Pro Pro Ala Arg Arg Gly Asn Tyr Asn Gly Met Asp 
1               5                   10                  15      


Val 
    


<210>  49
<211>  321
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Synthetic

<400>  49
gacatccaga tgacccagag ccccagcagc ctgagcgcca gcgtgggcga cagggtgacc       60

atcacctgca gggccagcca ggacatcagg aacgacctgg gctggtacca gcagaagccc      120

ggcaaggccc ccaagaggct gatcttcggc gccagcagcc tgcagagcgg cgtgcccctg      180

aggttcagcg gcagcggcag cggcaccgag ttcaccctga ccatcaacaa cctgcagccc      240

gaggacttcg ccaccttcta ctgcctgcag gacaacagct acccctggac cttcggccag      300

ggcaccaagg tggagatcaa g                                                321


<210>  50
<211>  107
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic

<400>  50

Asp Ile Gln Met Thr Gln Ser Pro Ser Ser Leu Ser Ala Ser Val Gly 
1               5                   10                  15      


Asp Arg Val Thr Ile Thr Cys Arg Ala Ser Gln Asp Ile Arg Asn Asp 
            20                  25                  30          


Leu Gly Trp Tyr Gln Gln Lys Pro Gly Lys Ala Pro Lys Arg Leu Ile 
        35                  40                  45              


Phe Gly Ala Ser Ser Leu Gln Ser Gly Val Pro Leu Arg Phe Ser Gly 
    50                  55                  60                  


Ser Gly Ser Gly Thr Glu Phe Thr Leu Thr Ile Asn Asn Leu Gln Pro 
65                  70                  75                  80  


Glu Asp Phe Ala Thr Phe Tyr Cys Leu Gln Asp Asn Ser Tyr Pro Trp 
                85                  90                  95      


Thr Phe Gly Gln Gly Thr Lys Val Glu Ile Lys 
            100                 105         


<210>  51
<211>  18
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Synthetic

<400>  51
caggacatca ggaacgac                                                     18


<210>  52
<211>  6
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic

<400>  52

Gln Asp Ile Arg Asn Asp 
1               5       


<210>  53
<211>  9
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Synthetic

<400>  53
ggcgccagc                                                                9


<210>  54
<211>  3
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic

<400>  54

Gly Ala Ser 
1           


<210>  55
<211>  27
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Synthetic

<400>  55
ctgcaggaca acagctaccc ctggacc                                           27


<210>  56
<211>  9
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic

<400>  56

Leu Gln Asp Asn Ser Tyr Pro Trp Thr 
1               5                   


<210>  57
<211>  1353
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Synthetic

<400>  57
caggtgcagc tggtggagag cggcggcggc gtggtgcagc ccggcaggag cctgaggctg       60

agctgcgtgg ccagcggctt catcctgagc cactacggca tgcactgggt gaggcaggcc      120

cccggcaagg gcctggagtg ggtggccgtg atctggttcg acggcaccaa caagtactac      180

gccgacagcg tgaagggcag gttcaccgtg agcagggaca acagcaagaa caccctgtac      240

atgcagatga acagcctgag ggccgaggac accgccgtgt actactgcgc cagggacccc      300

ccccccgcca ggaggggcaa ctacaacggc atggacgtgt ggggccaggg caccaccgtg      360

accgtgagca gcgccagcac caagggcccc agcgtgttcc ccctggcccc ctgcagcagg      420

agcaccagcg agagcaccgc cgccctgggc tgcctggtga aggactactt ccccgagccc      480

gtgaccgtga gctggaacag cggcgccctg accagcggcg tgcacacctt ccccgccgtg      540

ctgcagagca gcggcctgta cagcctgagc agcgtggtga ccgtgcccag cagcagcctg      600

ggcaccaaga cctacacctg caacgtggac cacaagccca gcaacaccaa ggtggacaag      660

agggtggaga gcaagtacgg ccccccctgc cccccctgcc ccgcccccga gttcctgggc      720

ggccccagcg tgttcctgtt cccccccaag cccaaggaca ccctgatgat cagcaggacc      780

cccgaggtga cctgcgtggt ggtggacgtg agccaggagg accccgaggt gcagttcaac      840

tggtacgtgg acggcgtgga ggtgcacaac gccaagacca agcccaggga ggagcagttc      900

aacagcacct acagggtggt gagcgtgctg accgtgctgc accaggactg gctgaacggc      960

aaggagtaca agtgcaaggt gagcaacaag ggcctgccca gcagcatcga gaagaccatc     1020

agcaaggcca agggccagcc cagggagccc caggtgtaca ccctgccccc cagccaggag     1080

gagatgacca agaaccaggt gagcctgacc tgcctggtga agggcttcta ccccagcgac     1140

atcgccgtgg agtgggagag caacggccag cccgagaaca actacaagac cacccccccc     1200

gtgctggaca gcgacggcag cttcttcctg tacagcaggc tgaccgtgga caagagcagg     1260

tggcaggagg gcaacgtgtt cagctgcagc gtgatgcacg aggccctgca caaccactac     1320

acccagaaga gcctgagcct gagcctgggc aag                                  1353


<210>  58
<211>  451
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic

<400>  58

Gln Val Gln Leu Val Glu Ser Gly Gly Gly Val Val Gln Pro Gly Arg 
1               5                   10                  15      


Ser Leu Arg Leu Ser Cys Val Ala Ser Gly Phe Ile Leu Ser His Tyr 
            20                  25                  30          


Gly Met His Trp Val Arg Gln Ala Pro Gly Lys Gly Leu Glu Trp Val 
        35                  40                  45              


Ala Val Ile Trp Phe Asp Gly Thr Asn Lys Tyr Tyr Ala Asp Ser Val 
    50                  55                  60                  


Lys Gly Arg Phe Thr Val Ser Arg Asp Asn Ser Lys Asn Thr Leu Tyr 
65                  70                  75                  80  


Met Gln Met Asn Ser Leu Arg Ala Glu Asp Thr Ala Val Tyr Tyr Cys 
                85                  90                  95      


Ala Arg Asp Pro Pro Pro Ala Arg Arg Gly Asn Tyr Asn Gly Met Asp 
            100                 105                 110         


Val Trp Gly Gln Gly Thr Thr Val Thr Val Ser Ser Ala Ser Thr Lys 
        115                 120                 125             


Gly Pro Ser Val Phe Pro Leu Ala Pro Cys Ser Arg Ser Thr Ser Glu 
    130                 135                 140                 


Ser Thr Ala Ala Leu Gly Cys Leu Val Lys Asp Tyr Phe Pro Glu Pro 
145                 150                 155                 160 


Val Thr Val Ser Trp Asn Ser Gly Ala Leu Thr Ser Gly Val His Thr 
                165                 170                 175     


Phe Pro Ala Val Leu Gln Ser Ser Gly Leu Tyr Ser Leu Ser Ser Val 
            180                 185                 190         


Val Thr Val Pro Ser Ser Ser Leu Gly Thr Lys Thr Tyr Thr Cys Asn 
        195                 200                 205             


Val Asp His Lys Pro Ser Asn Thr Lys Val Asp Lys Arg Val Glu Ser 
    210                 215                 220                 


Lys Tyr Gly Pro Pro Cys Pro Pro Cys Pro Ala Pro Glu Phe Leu Gly 
225                 230                 235                 240 


Gly Pro Ser Val Phe Leu Phe Pro Pro Lys Pro Lys Asp Thr Leu Met 
                245                 250                 255     


Ile Ser Arg Thr Pro Glu Val Thr Cys Val Val Val Asp Val Ser Gln 
            260                 265                 270         


Glu Asp Pro Glu Val Gln Phe Asn Trp Tyr Val Asp Gly Val Glu Val 
        275                 280                 285             


His Asn Ala Lys Thr Lys Pro Arg Glu Glu Gln Phe Asn Ser Thr Tyr 
    290                 295                 300                 


Arg Val Val Ser Val Leu Thr Val Leu His Gln Asp Trp Leu Asn Gly 
305                 310                 315                 320 


Lys Glu Tyr Lys Cys Lys Val Ser Asn Lys Gly Leu Pro Ser Ser Ile 
                325                 330                 335     


Glu Lys Thr Ile Ser Lys Ala Lys Gly Gln Pro Arg Glu Pro Gln Val 
            340                 345                 350         


Tyr Thr Leu Pro Pro Ser Gln Glu Glu Met Thr Lys Asn Gln Val Ser 
        355                 360                 365             


Leu Thr Cys Leu Val Lys Gly Phe Tyr Pro Ser Asp Ile Ala Val Glu 
    370                 375                 380                 


Trp Glu Ser Asn Gly Gln Pro Glu Asn Asn Tyr Lys Thr Thr Pro Pro 
385                 390                 395                 400 


Val Leu Asp Ser Asp Gly Ser Phe Phe Leu Tyr Ser Arg Leu Thr Val 
                405                 410                 415     


Asp Lys Ser Arg Trp Gln Glu Gly Asn Val Phe Ser Cys Ser Val Met 
            420                 425                 430         


His Glu Ala Leu His Asn His Tyr Thr Gln Lys Ser Leu Ser Leu Ser 
        435                 440                 445             


Leu Gly Lys 
    450     


<210>  59
<211>  642
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Synthetic

<400>  59
gacatccaga tgacccagag ccccagcagc ctgagcgcca gcgtgggcga cagggtgacc       60

atcacctgca gggccagcca ggacatcagg aacgacctgg gctggtacca gcagaagccc      120

ggcaaggccc ccaagaggct gatcttcggc gccagcagcc tgcagagcgg cgtgcccctg      180

aggttcagcg gcagcggcag cggcaccgag ttcaccctga ccatcaacaa cctgcagccc      240

gaggacttcg ccaccttcta ctgcctgcag gacaacagct acccctggac cttcggccag      300

ggcaccaagg tggagatcaa gaggaccgtg gccgccccca gcgtgttcat cttccccccc      360

agcgacgagc agctgaagag cggcaccgcc agcgtggtgt gcctgctgaa caacttctac      420

cccagggagg ccaaggtgca gtggaaggtg gacaacgccc tgcagagcgg caacagccag      480

gagagcgtga ccgagcagga cagcaaggac agcacctaca gcctgagcag caccctgacc      540

ctgagcaagg ccgactacga gaagcacaag gtgtacgcct gcgaggtgac ccaccagggc      600

ctgagcagcc ccgtgaccaa gagcttcaac aggggcgagt gc                         642


<210>  60
<211>  214
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic

<400>  60

Asp Ile Gln Met Thr Gln Ser Pro Ser Ser Leu Ser Ala Ser Val Gly 
1               5                   10                  15      


Asp Arg Val Thr Ile Thr Cys Arg Ala Ser Gln Asp Ile Arg Asn Asp 
            20                  25                  30          


Leu Gly Trp Tyr Gln Gln Lys Pro Gly Lys Ala Pro Lys Arg Leu Ile 
        35                  40                  45              


Phe Gly Ala Ser Ser Leu Gln Ser Gly Val Pro Leu Arg Phe Ser Gly 
    50                  55                  60                  


Ser Gly Ser Gly Thr Glu Phe Thr Leu Thr Ile Asn Asn Leu Gln Pro 
65                  70                  75                  80  


Glu Asp Phe Ala Thr Phe Tyr Cys Leu Gln Asp Asn Ser Tyr Pro Trp 
                85                  90                  95      


Thr Phe Gly Gln Gly Thr Lys Val Glu Ile Lys Arg Thr Val Ala Ala 
            100                 105                 110         


Pro Ser Val Phe Ile Phe Pro Pro Ser Asp Glu Gln Leu Lys Ser Gly 
        115                 120                 125             


Thr Ala Ser Val Val Cys Leu Leu Asn Asn Phe Tyr Pro Arg Glu Ala 
    130                 135                 140                 


Lys Val Gln Trp Lys Val Asp Asn Ala Leu Gln Ser Gly Asn Ser Gln 
145                 150                 155                 160 


Glu Ser Val Thr Glu Gln Asp Ser Lys Asp Ser Thr Tyr Ser Leu Ser 
                165                 170                 175     


Ser Thr Leu Thr Leu Ser Lys Ala Asp Tyr Glu Lys His Lys Val Tyr 
            180                 185                 190         


Ala Cys Glu Val Thr His Gln Gly Leu Ser Ser Pro Val Thr Lys Ser 
        195                 200                 205             


Phe Asn Arg Gly Glu Cys 
    210                 


<210>  61
<211>  369
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Synthetic

<400>  61
caggtgcagc tggtggagag cggcggcggc gtggtgcagc ccggcaggag cctgaggctg       60

agctgcgagg ccagcggctt caccttcagc gactacgacc tgcactgggt gaggcaggcc      120

cccggcaagg gcctggagtg ggtggccttc atcagcaacg acggcagcaa cgagtactac      180

cccaagagcg tgaagggcag gttcagcatc agcagggaca acagcaagaa caccctgtac      240

ctgcagatga acagcctgag ggccgaggac accgccgtgt accactgcac caaggagagg      300

gactactact acgacagcag cggcagcctg gactactggg gccagggcac cctggtgacc      360

gtgagcagc                                                              369


<210>  62
<211>  123
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic

<400>  62

Gln Val Gln Leu Val Glu Ser Gly Gly Gly Val Val Gln Pro Gly Arg 
1               5                   10                  15      


Ser Leu Arg Leu Ser Cys Glu Ala Ser Gly Phe Thr Phe Ser Asp Tyr 
            20                  25                  30          


Asp Leu His Trp Val Arg Gln Ala Pro Gly Lys Gly Leu Glu Trp Val 
        35                  40                  45              


Ala Phe Ile Ser Asn Asp Gly Ser Asn Glu Tyr Tyr Pro Lys Ser Val 
    50                  55                  60                  


Lys Gly Arg Phe Ser Ile Ser Arg Asp Asn Ser Lys Asn Thr Leu Tyr 
65                  70                  75                  80  


Leu Gln Met Asn Ser Leu Arg Ala Glu Asp Thr Ala Val Tyr His Cys 
                85                  90                  95      


Thr Lys Glu Arg Asp Tyr Tyr Tyr Asp Ser Ser Gly Ser Leu Asp Tyr 
            100                 105                 110         


Trp Gly Gln Gly Thr Leu Val Thr Val Ser Ser 
        115                 120             


<210>  63
<211>  24
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Synthetic

<400>  63
ggcttcacct tcagcgacta cgac                                              24


<210>  64
<211>  8
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic

<400>  64

Gly Phe Thr Phe Ser Asp Tyr Asp 
1               5               


<210>  65
<211>  24
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Synthetic

<400>  65
atcagcaacg acggcagcaa cgag                                              24


<210>  66
<211>  8
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic

<400>  66

Ile Ser Asn Asp Gly Ser Asn Glu 
1               5               


<210>  67
<211>  48
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Synthetic

<400>  67
accaaggaga gggactacta ctacgacagc agcggcagcc tggactac                    48


<210>  68
<211>  16
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic

<400>  68

Thr Lys Glu Arg Asp Tyr Tyr Tyr Asp Ser Ser Gly Ser Leu Asp Tyr 
1               5                   10                  15      


<210>  69
<211>  321
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Synthetic

<400>  69
gacatccaga tgacccagag ccccagcagc ctgagcgcca gcgtgggcga cagggtgacc       60

atcacctgca gggccagcca gaccatcaac aactacctga actggtacca gcagaagccc      120

ggcaaggccc ccaagctgct gatctacacc accagcggcc tgcagagcgg cgtgcccagc      180

aggttcagcg gcaggggcag cggcaccgac ttcaccctgg ccatcagcag cctgcagccc      240

gaggacttcg ccacctacta ctgccagcag agctaccaca gccccttcac cttcggcccc      300

ggcaccaagg tggacatcaa g                                                321


<210>  70
<211>  107
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic

<400>  70

Asp Ile Gln Met Thr Gln Ser Pro Ser Ser Leu Ser Ala Ser Val Gly 
1               5                   10                  15      


Asp Arg Val Thr Ile Thr Cys Arg Ala Ser Gln Thr Ile Asn Asn Tyr 
            20                  25                  30          


Leu Asn Trp Tyr Gln Gln Lys Pro Gly Lys Ala Pro Lys Leu Leu Ile 
        35                  40                  45              


Tyr Thr Thr Ser Gly Leu Gln Ser Gly Val Pro Ser Arg Phe Ser Gly 
    50                  55                  60                  


Arg Gly Ser Gly Thr Asp Phe Thr Leu Ala Ile Ser Ser Leu Gln Pro 
65                  70                  75                  80  


Glu Asp Phe Ala Thr Tyr Tyr Cys Gln Gln Ser Tyr His Ser Pro Phe 
                85                  90                  95      


Thr Phe Gly Pro Gly Thr Lys Val Asp Ile Lys 
            100                 105         


<210>  71
<211>  18
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Synthetic

<400>  71
cagaccatca acaactac                                                     18


<210>  72
<211>  6
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic

<400>  72

Gln Thr Ile Asn Asn Tyr 
1               5       


<210>  73
<211>  9
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Synthetic

<400>  73
accaccagc                                                                9


<210>  74
<211>  3
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic

<400>  74

Thr Thr Ser 
1           


<210>  75
<211>  27
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Synthetic

<400>  75
cagcagagct accacagccc cttcacc                                           27


<210>  76
<211>  9
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic

<400>  76

Gln Gln Ser Tyr His Ser Pro Phe Thr 
1               5                   


<210>  77
<211>  1350
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Synthetic

<400>  77
caggtgcagc tggtggagag cggcggcggc gtggtgcagc ccggcaggag cctgaggctg       60

agctgcgagg ccagcggctt caccttcagc gactacgacc tgcactgggt gaggcaggcc      120

cccggcaagg gcctggagtg ggtggccttc atcagcaacg acggcagcaa cgagtactac      180

cccaagagcg tgaagggcag gttcagcatc agcagggaca acagcaagaa caccctgtac      240

ctgcagatga acagcctgag ggccgaggac accgccgtgt accactgcac caaggagagg      300

gactactact acgacagcag cggcagcctg gactactggg gccagggcac cctggtgacc      360

gtgagcagcg ccagcaccaa gggccccagc gtgttccccc tggccccctg cagcaggagc      420

accagcgaga gcaccgccgc cctgggctgc ctggtgaagg actacttccc cgagcccgtg      480

accgtgagct ggaacagcgg cgccctgacc agcggcgtgc acaccttccc cgccgtgctg      540

cagagcagcg gcctgtacag cctgagcagc gtggtgaccg tgcccagcag cagcctgggc      600

accaagacct acacctgcaa cgtggaccac aagcccagca acaccaaggt ggacaagagg      660

gtggagagca agtacggccc cccctgcccc ccctgccccg cccccgagtt cctgggcggc      720

cccagcgtgt tcctgttccc ccccaagccc aaggacaccc tgatgatcag caggaccccc      780

gaggtgacct gcgtggtggt ggacgtgagc caggaggacc ccgaggtgca gttcaactgg      840

tacgtggacg gcgtggaggt gcacaacgcc aagaccaagc ccagggagga gcagttcaac      900

agcacctaca gggtggtgag cgtgctgacc gtgctgcacc aggactggct gaacggcaag      960

gagtacaagt gcaaggtgag caacaagggc ctgcccagca gcatcgagaa gaccatcagc     1020

aaggccaagg gccagcccag ggagccccag gtgtacaccc tgccccccag ccaggaggag     1080

atgaccaaga accaggtgag cctgacctgc ctggtgaagg gcttctaccc cagcgacatc     1140

gccgtggagt gggagagcaa cggccagccc gagaacaact acaagaccac cccccccgtg     1200

ctggacagcg acggcagctt cttcctgtac agcaggctga ccgtggacaa gagcaggtgg     1260

caggagggca acgtgttcag ctgcagcgtg atgcacgagg ccctgcacaa ccactacacc     1320

cagaagagcc tgagcctgag cctgggcaag                                      1350


<210>  78
<211>  450
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic

<400>  78

Gln Val Gln Leu Val Glu Ser Gly Gly Gly Val Val Gln Pro Gly Arg 
1               5                   10                  15      


Ser Leu Arg Leu Ser Cys Glu Ala Ser Gly Phe Thr Phe Ser Asp Tyr 
            20                  25                  30          


Asp Leu His Trp Val Arg Gln Ala Pro Gly Lys Gly Leu Glu Trp Val 
        35                  40                  45              


Ala Phe Ile Ser Asn Asp Gly Ser Asn Glu Tyr Tyr Pro Lys Ser Val 
    50                  55                  60                  


Lys Gly Arg Phe Ser Ile Ser Arg Asp Asn Ser Lys Asn Thr Leu Tyr 
65                  70                  75                  80  


Leu Gln Met Asn Ser Leu Arg Ala Glu Asp Thr Ala Val Tyr His Cys 
                85                  90                  95      


Thr Lys Glu Arg Asp Tyr Tyr Tyr Asp Ser Ser Gly Ser Leu Asp Tyr 
            100                 105                 110         


Trp Gly Gln Gly Thr Leu Val Thr Val Ser Ser Ala Ser Thr Lys Gly 
        115                 120                 125             


Pro Ser Val Phe Pro Leu Ala Pro Cys Ser Arg Ser Thr Ser Glu Ser 
    130                 135                 140                 


Thr Ala Ala Leu Gly Cys Leu Val Lys Asp Tyr Phe Pro Glu Pro Val 
145                 150                 155                 160 


Thr Val Ser Trp Asn Ser Gly Ala Leu Thr Ser Gly Val His Thr Phe 
                165                 170                 175     


Pro Ala Val Leu Gln Ser Ser Gly Leu Tyr Ser Leu Ser Ser Val Val 
            180                 185                 190         


Thr Val Pro Ser Ser Ser Leu Gly Thr Lys Thr Tyr Thr Cys Asn Val 
        195                 200                 205             


Asp His Lys Pro Ser Asn Thr Lys Val Asp Lys Arg Val Glu Ser Lys 
    210                 215                 220                 


Tyr Gly Pro Pro Cys Pro Pro Cys Pro Ala Pro Glu Phe Leu Gly Gly 
225                 230                 235                 240 


Pro Ser Val Phe Leu Phe Pro Pro Lys Pro Lys Asp Thr Leu Met Ile 
                245                 250                 255     


Ser Arg Thr Pro Glu Val Thr Cys Val Val Val Asp Val Ser Gln Glu 
            260                 265                 270         


Asp Pro Glu Val Gln Phe Asn Trp Tyr Val Asp Gly Val Glu Val His 
        275                 280                 285             


Asn Ala Lys Thr Lys Pro Arg Glu Glu Gln Phe Asn Ser Thr Tyr Arg 
    290                 295                 300                 


Val Val Ser Val Leu Thr Val Leu His Gln Asp Trp Leu Asn Gly Lys 
305                 310                 315                 320 


Glu Tyr Lys Cys Lys Val Ser Asn Lys Gly Leu Pro Ser Ser Ile Glu 
                325                 330                 335     


Lys Thr Ile Ser Lys Ala Lys Gly Gln Pro Arg Glu Pro Gln Val Tyr 
            340                 345                 350         


Thr Leu Pro Pro Ser Gln Glu Glu Met Thr Lys Asn Gln Val Ser Leu 
        355                 360                 365             


Thr Cys Leu Val Lys Gly Phe Tyr Pro Ser Asp Ile Ala Val Glu Trp 
    370                 375                 380                 


Glu Ser Asn Gly Gln Pro Glu Asn Asn Tyr Lys Thr Thr Pro Pro Val 
385                 390                 395                 400 


Leu Asp Ser Asp Gly Ser Phe Phe Leu Tyr Ser Arg Leu Thr Val Asp 
                405                 410                 415     


Lys Ser Arg Trp Gln Glu Gly Asn Val Phe Ser Cys Ser Val Met His 
            420                 425                 430         


Glu Ala Leu His Asn His Tyr Thr Gln Lys Ser Leu Ser Leu Ser Leu 
        435                 440                 445             


Gly Lys 
    450 


<210>  79
<211>  642
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Synthetic

<400>  79
gacatccaga tgacccagag ccccagcagc ctgagcgcca gcgtgggcga cagggtgacc       60

atcacctgca gggccagcca gaccatcaac aactacctga actggtacca gcagaagccc      120

ggcaaggccc ccaagctgct gatctacacc accagcggcc tgcagagcgg cgtgcccagc      180

aggttcagcg gcaggggcag cggcaccgac ttcaccctgg ccatcagcag cctgcagccc      240

gaggacttcg ccacctacta ctgccagcag agctaccaca gccccttcac cttcggcccc      300

ggcaccaagg tggacatcaa gaggaccgtg gccgccccca gcgtgttcat cttccccccc      360

agcgacgagc agctgaagag cggcaccgcc agcgtggtgt gcctgctgaa caacttctac      420

cccagggagg ccaaggtgca gtggaaggtg gacaacgccc tgcagagcgg caacagccag      480

gagagcgtga ccgagcagga cagcaaggac agcacctaca gcctgagcag caccctgacc      540

ctgagcaagg ccgactacga gaagcacaag gtgtacgcct gcgaggtgac ccaccagggc      600

ctgagcagcc ccgtgaccaa gagcttcaac aggggcgagt gc                         642


<210>  80
<211>  214
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic

<400>  80

Asp Ile Gln Met Thr Gln Ser Pro Ser Ser Leu Ser Ala Ser Val Gly 
1               5                   10                  15      


Asp Arg Val Thr Ile Thr Cys Arg Ala Ser Gln Thr Ile Asn Asn Tyr 
            20                  25                  30          


Leu Asn Trp Tyr Gln Gln Lys Pro Gly Lys Ala Pro Lys Leu Leu Ile 
        35                  40                  45              


Tyr Thr Thr Ser Gly Leu Gln Ser Gly Val Pro Ser Arg Phe Ser Gly 
    50                  55                  60                  


Arg Gly Ser Gly Thr Asp Phe Thr Leu Ala Ile Ser Ser Leu Gln Pro 
65                  70                  75                  80  


Glu Asp Phe Ala Thr Tyr Tyr Cys Gln Gln Ser Tyr His Ser Pro Phe 
                85                  90                  95      


Thr Phe Gly Pro Gly Thr Lys Val Asp Ile Lys Arg Thr Val Ala Ala 
            100                 105                 110         


Pro Ser Val Phe Ile Phe Pro Pro Ser Asp Glu Gln Leu Lys Ser Gly 
        115                 120                 125             


Thr Ala Ser Val Val Cys Leu Leu Asn Asn Phe Tyr Pro Arg Glu Ala 
    130                 135                 140                 


Lys Val Gln Trp Lys Val Asp Asn Ala Leu Gln Ser Gly Asn Ser Gln 
145                 150                 155                 160 


Glu Ser Val Thr Glu Gln Asp Ser Lys Asp Ser Thr Tyr Ser Leu Ser 
                165                 170                 175     


Ser Thr Leu Thr Leu Ser Lys Ala Asp Tyr Glu Lys His Lys Val Tyr 
            180                 185                 190         


Ala Cys Glu Val Thr His Gln Gly Leu Ser Ser Pro Val Thr Lys Ser 
        195                 200                 205             


Phe Asn Arg Gly Glu Cys 
    210                 


<210>  81
<211>  220
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic

<400>  81

Met Glu Leu Gly Leu Gly Gly Leu Ser Thr Leu Ser His Cys Pro Trp 
1               5                   10                  15      


Pro Arg Gln Gln Pro Ala Leu Trp Pro Thr Leu Ala Ala Leu Ala Leu 
            20                  25                  30          


Leu Ser Ser Val Ala Glu Ala Ser Leu Gly Ser Ala Pro Arg Ser Pro 
        35                  40                  45              


Ala Pro Arg Glu Gly Pro Pro Pro Val Leu Ala Ser Pro Ala Gly His 
    50                  55                  60                  


Leu Pro Gly Gly Arg Thr Ala Arg Trp Cys Ser Gly Arg Ala Arg Arg 
65                  70                  75                  80  


Pro Pro Pro Gln Pro Ser Arg Pro Ala Pro Pro Pro Pro Ala Pro Pro 
                85                  90                  95      


Ser Ala Leu Pro Arg Gly Gly Arg Ala Ala Arg Ala Gly Gly Pro Gly 
            100                 105                 110         


Ser Arg Ala Arg Ala Ala Gly Ala Arg Gly Cys Arg Leu Arg Ser Gln 
        115                 120                 125             


Leu Val Pro Val Arg Ala Leu Gly Leu Gly His Arg Ser Asp Glu Leu 
    130                 135                 140                 


Val Arg Phe Arg Phe Cys Ser Gly Ser Cys Arg Arg Ala Arg Ser Pro 
145                 150                 155                 160 


His Asp Leu Ser Leu Ala Ser Leu Leu Gly Ala Gly Ala Leu Arg Pro 
                165                 170                 175     


Pro Pro Gly Ser Arg Pro Val Ser Gln Pro Cys Cys Arg Pro Thr Arg 
            180                 185                 190         


Tyr Glu Ala Val Ser Phe Met Asp Val Asn Ser Thr Trp Arg Thr Val 
        195                 200                 205             


Asp Arg Leu Ser Ala Thr Ala Cys Gly Cys Leu Gly 
    210                 215                 220 


<210>  82
<211>  141
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic

<400>  82

Ala Gly Gly Pro Gly Ser Arg Ala Arg Ala Ala Gly Ala Arg Gly Cys 
1               5                   10                  15      


Arg Leu Arg Ser Gln Leu Val Pro Val Arg Ala Leu Gly Leu Gly His 
            20                  25                  30          


Arg Ser Asp Glu Leu Val Arg Phe Arg Phe Cys Ser Gly Ser Cys Arg 
        35                  40                  45              


Arg Ala Arg Ser Pro His Asp Leu Ser Leu Ala Ser Leu Leu Gly Ala 
    50                  55                  60                  


Gly Ala Leu Arg Pro Pro Pro Gly Ser Arg Pro Val Ser Gln Pro Cys 
65                  70                  75                  80  


Cys Arg Pro Thr Arg Tyr Glu Ala Val Ser Phe Met Asp Val Asn Ser 
                85                  90                  95      


Thr Trp Arg Thr Val Asp Arg Leu Ser Ala Thr Ala Cys Gly Cys Leu 
            100                 105                 110         


Gly Glu Gln Lys Leu Ile Ser Glu Glu Asp Leu Gly Gly Glu Gln Lys 
        115                 120                 125             


Leu Ile Ser Glu Glu Asp Leu His His His His His His 
    130                 135                 140     


<210>  83
<211>  141
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic

<400>  83

Ala Gly Gly Pro Gly Ser Arg Pro Arg Ala Ala Gly Ala Arg Gly Cys 
1               5                   10                  15      


Arg Leu Arg Ser Gln Leu Val Pro Val Arg Ala Leu Gly Leu Gly His 
            20                  25                  30          


Arg Ser Asp Glu Leu Val Arg Phe Arg Phe Cys Ser Gly Ser Cys Arg 
        35                  40                  45              


Arg Ala Arg Ser Pro His Asp Leu Ser Leu Ala Ser Leu Leu Gly Ala 
    50                  55                  60                  


Gly Ala Leu Arg Pro Pro Pro Gly Ser Arg Pro Ile Ser Gln Pro Cys 
65                  70                  75                  80  


Cys Arg Pro Thr Arg Tyr Glu Ala Val Ser Phe Met Asp Val Asn Ser 
                85                  90                  95      


Thr Trp Arg Thr Val Asp Arg Leu Ser Ala Thr Ala Cys Gly Cys Leu 
            100                 105                 110         


Gly Glu Gln Lys Leu Ile Ser Glu Glu Asp Leu Gly Gly Glu Gln Lys 
        115                 120                 125             


Leu Ile Ser Glu Glu Asp Leu His His His His His His 
    130                 135                 140     


<210>  84
<211>  141
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic

<400>  84

Ala Gly Thr Arg Ser Ser Arg Ala Arg Thr Thr Asp Ala Arg Gly Cys 
1               5                   10                  15      


Arg Leu Arg Ser Gln Leu Val Pro Val Ser Ala Leu Gly Leu Gly His 
            20                  25                  30          


Ser Ser Asp Glu Leu Ile Arg Phe Arg Phe Cys Ser Gly Ser Cys Arg 
        35                  40                  45              


Arg Ala Arg Ser Gln His Asp Leu Ser Leu Ala Ser Leu Leu Gly Ala 
    50                  55                  60                  


Gly Ala Leu Arg Ser Pro Pro Gly Ser Arg Pro Ile Ser Gln Pro Cys 
65                  70                  75                  80  


Cys Arg Pro Thr Arg Tyr Glu Ala Val Ser Phe Met Asp Val Asn Ser 
                85                  90                  95      


Thr Trp Arg Thr Val Asp His Leu Ser Ala Thr Ala Cys Gly Cys Leu 
            100                 105                 110         


Gly Glu Gln Lys Leu Ile Ser Glu Glu Asp Leu Gly Gly Glu Gln Lys 
        115                 120                 125             


Leu Ile Ser Glu Glu Asp Leu His His His His His His 
    130                 135                 140     


<210>  85
<211>  578
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic

<400>  85

Asp Pro Leu Pro Thr Glu Ser Arg Leu Met Asn Ser Cys Leu Gln Ala 
1               5                   10                  15      


Arg Arg Lys Cys Gln Ala Asp Pro Thr Cys Ser Ala Ala Tyr His His 
            20                  25                  30          


Leu Asp Ser Cys Thr Ser Ser Ile Ser Thr Pro Leu Pro Ser Glu Glu 
        35                  40                  45              


Pro Ser Val Pro Ala Asp Cys Leu Glu Ala Ala Gln Gln Leu Arg Asn 
    50                  55                  60                  


Ser Ser Leu Ile Gly Cys Met Cys His Arg Arg Met Lys Asn Gln Val 
65                  70                  75                  80  


Ala Cys Leu Asp Ile Tyr Trp Thr Val His Arg Ala Arg Ser Leu Gly 
                85                  90                  95      


Asn Tyr Glu Leu Asp Val Ser Pro Tyr Glu Asp Thr Val Thr Ser Lys 
            100                 105                 110         


Pro Trp Lys Met Asn Leu Ser Lys Leu Asn Met Leu Lys Pro Asp Ser 
        115                 120                 125             


Asp Leu Cys Leu Lys Phe Ala Met Leu Cys Thr Leu Asn Asp Lys Cys 
    130                 135                 140                 


Asp Arg Leu Arg Lys Ala Tyr Gly Glu Ala Cys Ser Gly Pro His Cys 
145                 150                 155                 160 


Gln Arg His Val Cys Leu Arg Gln Leu Leu Thr Phe Phe Glu Lys Ala 
                165                 170                 175     


Ala Glu Pro His Ala Gln Gly Leu Leu Leu Cys Pro Cys Ala Pro Asn 
            180                 185                 190         


Asp Arg Gly Cys Gly Glu Arg Arg Arg Asn Thr Ile Ala Pro Asn Cys 
        195                 200                 205             


Ala Leu Pro Pro Val Ala Pro Asn Cys Leu Glu Leu Arg Arg Leu Cys 
    210                 215                 220                 


Phe Ser Asp Pro Leu Cys Arg Ser Arg Leu Val Asp Phe Gln Thr His 
225                 230                 235                 240 


Cys His Pro Met Asp Ile Leu Gly Thr Cys Ala Thr Glu Gln Ser Arg 
                245                 250                 255     


Cys Leu Arg Ala Tyr Leu Gly Leu Ile Gly Thr Ala Met Thr Pro Asn 
            260                 265                 270         


Phe Val Ser Asn Val Asn Thr Ser Val Ala Leu Ser Cys Thr Cys Arg 
        275                 280                 285             


Gly Ser Gly Asn Leu Gln Glu Glu Cys Glu Met Leu Glu Gly Phe Phe 
    290                 295                 300                 


Ser His Asn Pro Cys Leu Thr Glu Ala Ile Ala Ala Lys Met Arg Phe 
305                 310                 315                 320 


His Ser Gln Leu Phe Ser Gln Asp Trp Pro His Pro Thr Phe Ala Val 
                325                 330                 335     


Met Ala His Gln Asn Glu Asn Pro Ala Val Arg Pro Gln Pro Trp Asp 
            340                 345                 350         


Lys Thr His Thr Cys Pro Pro Cys Pro Ala Pro Glu Leu Leu Gly Gly 
        355                 360                 365             


Pro Ser Val Phe Leu Phe Pro Pro Lys Pro Lys Asp Thr Leu Met Ile 
    370                 375                 380                 


Ser Arg Thr Pro Glu Val Thr Cys Val Val Val Asp Val Ser His Glu 
385                 390                 395                 400 


Asp Pro Glu Val Lys Phe Asn Trp Tyr Val Asp Gly Val Glu Val His 
                405                 410                 415     


Asn Ala Lys Thr Lys Pro Arg Glu Glu Gln Tyr Asn Ser Thr Tyr Arg 
            420                 425                 430         


Val Val Ser Val Leu Thr Val Leu His Gln Asp Trp Leu Asn Gly Lys 
        435                 440                 445             


Glu Tyr Lys Cys Lys Val Ser Asn Lys Ala Leu Pro Ala Pro Ile Glu 
    450                 455                 460                 


Lys Thr Ile Ser Lys Ala Lys Gly Gln Pro Arg Glu Pro Gln Val Tyr 
465                 470                 475                 480 


Thr Leu Pro Pro Ser Arg Asp Glu Leu Thr Lys Asn Gln Val Ser Leu 
                485                 490                 495     


Thr Cys Leu Val Lys Gly Phe Tyr Pro Ser Asp Ile Ala Val Glu Trp 
            500                 505                 510         


Glu Ser Asn Gly Gln Pro Glu Asn Asn Tyr Lys Thr Thr Pro Pro Val 
        515                 520                 525             


Leu Asp Ser Asp Gly Ser Phe Phe Leu Tyr Ser Lys Leu Thr Val Asp 
    530                 535                 540                 


Lys Ser Arg Trp Gln Gln Gly Asn Val Phe Ser Cys Ser Val Met His 
545                 550                 555                 560 


Glu Ala Leu His Asn His Tyr Thr Gln Lys Ser Leu Ser Leu Ser Pro 
                565                 570                 575     


Gly Lys 
        


