                         SEQUENCE LISTING

<110>  Iovance Biotherapeutics, Inc.
 
<120>  CHIMERIC COSTIMULATORY RECEPTORS AND USE OF SAME IN CELLULAR 
       IMMUNOTHERAPIES

<130>  116983-5046-WO

<140>  PCT/US2022/025420
<141>  2022-04-19

<150>  US 63/284,177
<151>  2021-11-30

<150>  US 63/254,297
<151>  2021-10-11

<150>  US 63/223,925
<151>  2021-07-20

<150>  US 63/176,675
<151>  2021-04-19

<160>  723   

<170>  PatentIn version 3.5

<210>  1
<211>  450
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic Muromonab heavy chain

<400>  1

Gln Val Gln Leu Gln Gln Ser Gly Ala Glu Leu Ala Arg Pro Gly Ala 
1               5                   10                  15      


Ser Val Lys Met Ser Cys Lys Ala Ser Gly Tyr Thr Phe Thr Arg Tyr 
            20                  25                  30          


Thr Met His Trp Val Lys Gln Arg Pro Gly Gln Gly Leu Glu Trp Ile 
        35                  40                  45              


Gly Tyr Ile Asn Pro Ser Arg Gly Tyr Thr Asn Tyr Asn Gln Lys Phe 
    50                  55                  60                  


Lys Asp Lys Ala Thr Leu Thr Thr Asp Lys Ser Ser Ser Thr Ala Tyr 
65                  70                  75                  80  


Met Gln Leu Ser Ser Leu Thr Ser Glu Asp Ser Ala Val Tyr Tyr Cys 
                85                  90                  95      


Ala Arg Tyr Tyr Asp Asp His Tyr Cys Leu Asp Tyr Trp Gly Gln Gly 
            100                 105                 110         


Thr Thr Leu Thr Val Ser Ser Ala Lys Thr Thr Ala Pro Ser Val Tyr 
        115                 120                 125             


Pro Leu Ala Pro Val Cys Gly Gly Thr Thr Gly Ser Ser Val Thr Leu 
    130                 135                 140                 


Gly Cys Leu Val Lys Gly Tyr Phe Pro Glu Pro Val Thr Leu Thr Trp 
145                 150                 155                 160 


Asn Ser Gly Ser Leu Ser Ser Gly Val His Thr Phe Pro Ala Val Leu 
                165                 170                 175     


Gln Ser Asp Leu Tyr Thr Leu Ser Ser Ser Val Thr Val Thr Ser Ser 
            180                 185                 190         


Thr Trp Pro Ser Gln Ser Ile Thr Cys Asn Val Ala His Pro Ala Ser 
        195                 200                 205             


Ser Thr Lys Val Asp Lys Lys Ile Glu Pro Arg Pro Lys Ser Cys Asp 
    210                 215                 220                 


Lys Thr His Thr Cys Pro Pro Cys Pro Ala Pro Glu Leu Leu Gly Gly 
225                 230                 235                 240 


Pro Ser Val Phe Leu Phe Pro Pro Lys Pro Lys Asp Thr Leu Met Ile 
                245                 250                 255     


Ser Arg Thr Pro Glu Val Thr Cys Val Val Val Asp Val Ser His Glu 
            260                 265                 270         


Asp Pro Glu Val Lys Phe Asn Trp Tyr Val Asp Gly Val Glu Val His 
        275                 280                 285             


Asn Ala Lys Thr Lys Pro Arg Glu Glu Gln Tyr Asn Ser Thr Tyr Arg 
    290                 295                 300                 


Val Val Ser Val Leu Thr Val Leu His Gln Asp Trp Leu Asn Gly Lys 
305                 310                 315                 320 


Glu Tyr Lys Cys Lys Val Ser Asn Lys Ala Leu Pro Ala Pro Ile Glu 
                325                 330                 335     


Lys Thr Ile Ser Lys Ala Lys Gly Gln Pro Arg Glu Pro Gln Val Tyr 
            340                 345                 350         


Thr Leu Pro Pro Ser Arg Asp Glu Leu Thr Lys Asn Gln Val Ser Leu 
        355                 360                 365             


Thr Cys Leu Val Lys Gly Phe Tyr Pro Ser Asp Ile Ala Val Glu Trp 
    370                 375                 380                 


Glu Ser Asn Gly Gln Pro Glu Asn Asn Tyr Lys Thr Thr Pro Pro Val 
385                 390                 395                 400 


Leu Asp Ser Asp Gly Ser Phe Phe Leu Tyr Ser Lys Leu Thr Val Asp 
                405                 410                 415     


Lys Ser Arg Trp Gln Gln Gly Asn Val Phe Ser Cys Ser Val Met His 
            420                 425                 430         


Glu Ala Leu His Asn His Tyr Thr Gln Lys Ser Leu Ser Leu Ser Pro 
        435                 440                 445             


Gly Lys 
    450 


<210>  2
<211>  213
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic Muromonab light chain

<400>  2

Gln Ile Val Leu Thr Gln Ser Pro Ala Ile Met Ser Ala Ser Pro Gly 
1               5                   10                  15      


Glu Lys Val Thr Met Thr Cys Ser Ala Ser Ser Ser Val Ser Tyr Met 
            20                  25                  30          


Asn Trp Tyr Gln Gln Lys Ser Gly Thr Ser Pro Lys Arg Trp Ile Tyr 
        35                  40                  45              


Asp Thr Ser Lys Leu Ala Ser Gly Val Pro Ala His Phe Arg Gly Ser 
    50                  55                  60                  


Gly Ser Gly Thr Ser Tyr Ser Leu Thr Ile Ser Gly Met Glu Ala Glu 
65                  70                  75                  80  


Asp Ala Ala Thr Tyr Tyr Cys Gln Gln Trp Ser Ser Asn Pro Phe Thr 
                85                  90                  95      


Phe Gly Ser Gly Thr Lys Leu Glu Ile Asn Arg Ala Asp Thr Ala Pro 
            100                 105                 110         


Thr Val Ser Ile Phe Pro Pro Ser Ser Glu Gln Leu Thr Ser Gly Gly 
        115                 120                 125             


Ala Ser Val Val Cys Phe Leu Asn Asn Phe Tyr Pro Lys Asp Ile Asn 
    130                 135                 140                 


Val Lys Trp Lys Ile Asp Gly Ser Glu Arg Gln Asn Gly Val Leu Asn 
145                 150                 155                 160 


Ser Trp Thr Asp Gln Asp Ser Lys Asp Ser Thr Tyr Ser Met Ser Ser 
                165                 170                 175     


Thr Leu Thr Leu Thr Lys Asp Glu Tyr Glu Arg His Asn Ser Tyr Thr 
            180                 185                 190         


Cys Glu Ala Thr His Lys Thr Ser Thr Ser Pro Ile Val Lys Ser Phe 
        195                 200                 205             


Asn Arg Asn Glu Cys 
    210             


<210>  3
<211>  134
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic recombinant human IL-2 (rhIL-2)

<400>  3

Met Ala Pro Thr Ser Ser Ser Thr Lys Lys Thr Gln Leu Gln Leu Glu 
1               5                   10                  15      


His Leu Leu Leu Asp Leu Gln Met Ile Leu Asn Gly Ile Asn Asn Tyr 
            20                  25                  30          


Lys Asn Pro Lys Leu Thr Arg Met Leu Thr Phe Lys Phe Tyr Met Pro 
        35                  40                  45              


Lys Lys Ala Thr Glu Leu Lys His Leu Gln Cys Leu Glu Glu Glu Leu 
    50                  55                  60                  


Lys Pro Leu Glu Glu Val Leu Asn Leu Ala Gln Ser Lys Asn Phe His 
65                  70                  75                  80  


Leu Arg Pro Arg Asp Leu Ile Ser Asn Ile Asn Val Ile Val Leu Glu 
                85                  90                  95      


Leu Lys Gly Ser Glu Thr Thr Phe Met Cys Glu Tyr Ala Asp Glu Thr 
            100                 105                 110         


Ala Thr Ile Val Glu Phe Leu Asn Arg Trp Ile Thr Phe Cys Gln Ser 
        115                 120                 125             


Ile Ile Ser Thr Leu Thr 
    130                 


<210>  4
<211>  132
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic Aldesleukin

<400>  4

Pro Thr Ser Ser Ser Thr Lys Lys Thr Gln Leu Gln Leu Glu His Leu 
1               5                   10                  15      


Leu Leu Asp Leu Gln Met Ile Leu Asn Gly Ile Asn Asn Tyr Lys Asn 
            20                  25                  30          


Pro Lys Leu Thr Arg Met Leu Thr Phe Lys Phe Tyr Met Pro Lys Lys 
        35                  40                  45              


Ala Thr Glu Leu Lys His Leu Gln Cys Leu Glu Glu Glu Leu Lys Pro 
    50                  55                  60                  


Leu Glu Glu Val Leu Asn Leu Ala Gln Ser Lys Asn Phe His Leu Arg 
65                  70                  75                  80  


Pro Arg Asp Leu Ile Ser Asn Ile Asn Val Ile Val Leu Glu Leu Lys 
                85                  90                  95      


Gly Ser Glu Thr Thr Phe Met Cys Glu Tyr Ala Asp Glu Thr Ala Thr 
            100                 105                 110         


Ile Val Glu Phe Leu Asn Arg Trp Ile Thr Phe Ser Gln Ser Ile Ile 
        115                 120                 125             


Ser Thr Leu Thr 
    130         


<210>  5
<211>  133
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic IL-2 form

<400>  5

Ala Pro Thr Ser Ser Ser Thr Lys Lys Thr Gln Leu Gln Leu Glu His 
1               5                   10                  15      


Leu Leu Leu Asp Leu Gln Met Ile Leu Asn Gly Ile Asn Asn Tyr Lys 
            20                  25                  30          


Asn Pro Lys Leu Thr Arg Met Leu Thr Phe Lys Phe Tyr Met Pro Lys 
        35                  40                  45              


Lys Ala Thr Glu Leu Lys His Leu Gln Cys Leu Glu Glu Glu Leu Lys 
    50                  55                  60                  


Pro Leu Glu Glu Val Leu Asn Leu Ala Gln Ser Lys Asn Phe His Leu 
65                  70                  75                  80  


Arg Pro Arg Asp Leu Ile Ser Asn Ile Asn Val Ile Val Leu Glu Leu 
                85                  90                  95      


Lys Gly Ser Glu Thr Thr Phe Met Cys Glu Tyr Ala Asp Glu Thr Ala 
            100                 105                 110         


Thr Ile Val Glu Phe Leu Asn Arg Trp Ile Thr Phe Cys Gln Ser Ile 
        115                 120                 125             


Ile Ser Thr Leu Thr 
    130             


<210>  6
<211>  303
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic IL-2 form

<400>  6

Ser Lys Asn Phe His Leu Arg Pro Arg Asp Leu Ile Ser Asn Ile Asn 
1               5                   10                  15      


Val Ile Val Leu Glu Leu Lys Gly Ser Glu Thr Thr Phe Met Cys Glu 
            20                  25                  30          


Tyr Ala Asp Glu Thr Ala Thr Ile Val Glu Phe Leu Asn Arg Trp Ile 
        35                  40                  45              


Thr Phe Ser Gln Ser Ile Ile Ser Thr Leu Thr Gly Gly Ser Ser Ser 
    50                  55                  60                  


Thr Lys Lys Thr Gln Leu Gln Leu Glu His Leu Leu Leu Asp Leu Gln 
65                  70                  75                  80  


Met Ile Leu Asn Gly Ile Asn Asn Tyr Lys Asn Pro Lys Leu Thr Arg 
                85                  90                  95      


Met Leu Thr Phe Lys Phe Tyr Met Pro Lys Lys Ala Thr Glu Leu Lys 
            100                 105                 110         


His Leu Gln Cys Leu Glu Glu Glu Leu Lys Pro Leu Glu Glu Val Leu 
        115                 120                 125             


Asn Leu Ala Gln Gly Ser Gly Gly Gly Ser Glu Leu Cys Asp Asp Asp 
    130                 135                 140                 


Pro Pro Glu Ile Pro His Ala Thr Phe Lys Ala Met Ala Tyr Lys Glu 
145                 150                 155                 160 


Gly Thr Met Leu Asn Cys Glu Cys Lys Arg Gly Phe Arg Arg Ile Lys 
                165                 170                 175     


Ser Gly Ser Leu Tyr Met Leu Cys Thr Gly Asn Ser Ser His Ser Ser 
            180                 185                 190         


Trp Asp Asn Gln Cys Gln Cys Thr Ser Ser Ala Thr Arg Asn Thr Thr 
        195                 200                 205             


Lys Gln Val Thr Pro Gln Pro Glu Glu Gln Lys Glu Arg Lys Thr Thr 
    210                 215                 220                 


Glu Met Gln Ser Pro Met Gln Pro Val Asp Gln Ala Ser Leu Pro Gly 
225                 230                 235                 240 


His Cys Arg Glu Pro Pro Pro Trp Glu Asn Glu Ala Thr Glu Arg Ile 
                245                 250                 255     


Tyr His Phe Val Val Gly Gln Met Val Tyr Tyr Gln Cys Val Gln Gly 
            260                 265                 270         


Tyr Arg Ala Leu His Arg Gly Pro Ala Glu Ser Val Cys Lys Met Thr 
        275                 280                 285             


His Gly Lys Thr Arg Trp Thr Gln Pro Gln Leu Ile Cys Thr Gly 
    290                 295                 300             


<210>  7
<211>  452
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic IL-2 form

<400>  7

Met Asp Ala Met Lys Arg Gly Leu Cys Cys Val Leu Leu Leu Cys Gly 
1               5                   10                  15      


Ala Val Phe Val Ser Ala Arg Arg Pro Ser Gly Arg Lys Ser Ser Lys 
            20                  25                  30          


Met Gln Ala Phe Arg Ile Trp Asp Val Asn Gln Lys Thr Phe Tyr Leu 
        35                  40                  45              


Arg Asn Asn Gln Leu Val Ala Gly Tyr Leu Gln Gly Pro Asn Val Asn 
    50                  55                  60                  


Leu Glu Glu Lys Ile Asp Val Val Pro Ile Glu Pro His Ala Leu Phe 
65                  70                  75                  80  


Leu Gly Ile His Gly Gly Lys Met Cys Leu Ser Cys Val Lys Ser Gly 
                85                  90                  95      


Asp Glu Thr Arg Leu Gln Leu Glu Ala Val Asn Ile Thr Asp Leu Ser 
            100                 105                 110         


Glu Asn Arg Lys Gln Asp Lys Arg Phe Ala Phe Ile Arg Ser Asp Ser 
        115                 120                 125             


Gly Pro Thr Thr Ser Phe Glu Ser Ala Ala Cys Pro Gly Trp Phe Leu 
    130                 135                 140                 


Cys Thr Ala Met Glu Ala Asp Gln Pro Val Ser Leu Thr Asn Met Pro 
145                 150                 155                 160 


Asp Glu Gly Val Met Val Thr Lys Phe Tyr Phe Gln Glu Asp Glu Ser 
                165                 170                 175     


Gly Ser Gly Gly Ala Ser Ser Glu Ser Ser Ala Ser Ser Asp Gly Pro 
            180                 185                 190         


His Pro Val Ile Thr Glu Ser Arg Ala Ser Ser Glu Ser Ser Ala Ser 
        195                 200                 205             


Ser Asp Gly Pro His Pro Val Ile Thr Glu Ser Arg Glu Pro Lys Ser 
    210                 215                 220                 


Ser Asp Lys Thr His Thr Cys Pro Pro Cys Pro Ala Pro Glu Leu Leu 
225                 230                 235                 240 


Gly Gly Pro Ser Val Phe Leu Phe Pro Pro Lys Pro Lys Asp Thr Leu 
                245                 250                 255     


Met Ile Ser Arg Thr Pro Glu Val Thr Cys Val Val Val Asp Val Ser 
            260                 265                 270         


His Glu Asp Pro Glu Val Lys Phe Asn Trp Tyr Val Asp Gly Val Glu 
        275                 280                 285             


Val His Asn Ala Lys Thr Lys Pro Arg Glu Glu Gln Tyr Asn Ser Thr 
    290                 295                 300                 


Tyr Arg Val Val Ser Val Leu Thr Val Leu His Gln Asp Trp Leu Asn 
305                 310                 315                 320 


Gly Lys Glu Tyr Lys Cys Lys Val Ser Asn Lys Ala Leu Pro Ala Pro 
                325                 330                 335     


Ile Glu Lys Thr Ile Ser Lys Ala Lys Gly Gln Pro Arg Glu Pro Gln 
            340                 345                 350         


Val Tyr Thr Leu Pro Pro Ser Arg Glu Glu Met Thr Lys Asn Gln Val 
        355                 360                 365             


Ser Leu Thr Cys Leu Val Lys Gly Phe Tyr Pro Ser Asp Ile Ala Val 
    370                 375                 380                 


Glu Trp Glu Ser Asn Gly Gln Pro Glu Asn Asn Tyr Lys Thr Thr Pro 
385                 390                 395                 400 


Pro Val Leu Asp Ser Asp Gly Ser Phe Phe Leu Tyr Ser Lys Leu Thr 
                405                 410                 415     


Val Asp Lys Ser Arg Trp Gln Gln Gly Asn Val Phe Ser Cys Ser Val 
            420                 425                 430         


Met His Glu Ala Leu His Asn His Tyr Thr Gln Lys Ser Leu Ser Leu 
        435                 440                 445             


Ser Pro Gly Lys 
    450         


<210>  8
<211>  16
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic mucin domain polypeptide

<400>  8

Ser Glu Ser Ser Ala Ser Ser Asp Gly Pro His Pro Val Ile Thr Pro 
1               5                   10                  15      


<210>  9
<211>  130
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic recombinant human IL-4 (rhIL-4)

<400>  9

Met His Lys Cys Asp Ile Thr Leu Gln Glu Ile Ile Lys Thr Leu Asn 
1               5                   10                  15      


Ser Leu Thr Glu Gln Lys Thr Leu Cys Thr Glu Leu Thr Val Thr Asp 
            20                  25                  30          


Ile Phe Ala Ala Ser Lys Asn Thr Thr Glu Lys Glu Thr Phe Cys Arg 
        35                  40                  45              


Ala Ala Thr Val Leu Arg Gln Phe Tyr Ser His His Glu Lys Asp Thr 
    50                  55                  60                  


Arg Cys Leu Gly Ala Thr Ala Gln Gln Phe His Arg His Lys Gln Leu 
65                  70                  75                  80  


Ile Arg Phe Leu Lys Arg Leu Asp Arg Asn Leu Trp Gly Leu Ala Gly 
                85                  90                  95      


Leu Asn Ser Cys Pro Val Lys Glu Ala Asn Gln Ser Thr Leu Glu Asn 
            100                 105                 110         


Phe Leu Glu Arg Leu Lys Thr Ile Met Arg Glu Lys Tyr Ser Lys Cys 
        115                 120                 125             


Ser Ser 
    130 


<210>  10
<211>  153
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic recombinant human IL-7 (rhIL-7)

<400>  10

Met Asp Cys Asp Ile Glu Gly Lys Asp Gly Lys Gln Tyr Glu Ser Val 
1               5                   10                  15      


Leu Met Val Ser Ile Asp Gln Leu Leu Asp Ser Met Lys Glu Ile Gly 
            20                  25                  30          


Ser Asn Cys Leu Asn Asn Glu Phe Asn Phe Phe Lys Arg His Ile Cys 
        35                  40                  45              


Asp Ala Asn Lys Glu Gly Met Phe Leu Phe Arg Ala Ala Arg Lys Leu 
    50                  55                  60                  


Arg Gln Phe Leu Lys Met Asn Ser Thr Gly Asp Phe Asp Leu His Leu 
65                  70                  75                  80  


Leu Lys Val Ser Glu Gly Thr Thr Ile Leu Leu Asn Cys Thr Gly Gln 
                85                  90                  95      


Val Lys Gly Arg Lys Pro Ala Ala Leu Gly Glu Ala Gln Pro Thr Lys 
            100                 105                 110         


Ser Leu Glu Glu Asn Lys Ser Leu Lys Glu Gln Lys Lys Leu Asn Asp 
        115                 120                 125             


Leu Cys Phe Leu Lys Arg Leu Leu Gln Glu Ile Lys Thr Cys Trp Asn 
    130                 135                 140                 


Lys Ile Leu Met Gly Thr Lys Glu His 
145                 150             


<210>  11
<211>  115
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic recombinant human IL-15 (rhIL-15)

<400>  11

Met Asn Trp Val Asn Val Ile Ser Asp Leu Lys Lys Ile Glu Asp Leu 
1               5                   10                  15      


Ile Gln Ser Met His Ile Asp Ala Thr Leu Tyr Thr Glu Ser Asp Val 
            20                  25                  30          


His Pro Ser Cys Lys Val Thr Ala Met Lys Cys Phe Leu Leu Glu Leu 
        35                  40                  45              


Gln Val Ile Ser Leu Glu Ser Gly Asp Ala Ser Ile His Asp Thr Val 
    50                  55                  60                  


Glu Asn Leu Ile Ile Leu Ala Asn Asn Ser Leu Ser Ser Asn Gly Asn 
65                  70                  75                  80  


Val Thr Glu Ser Gly Cys Lys Glu Cys Glu Glu Leu Glu Glu Lys Asn 
                85                  90                  95      


Ile Lys Glu Phe Leu Gln Ser Phe Val His Ile Val Gln Met Phe Ile 
            100                 105                 110         


Asn Thr Ser 
        115 


<210>  12
<211>  132
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic recombinant human IL-21 (rhIL-21)

<400>  12

Met Gln Asp Arg His Met Ile Arg Met Arg Gln Leu Ile Asp Ile Val 
1               5                   10                  15      


Asp Gln Leu Lys Asn Tyr Val Asn Asp Leu Val Pro Glu Phe Leu Pro 
            20                  25                  30          


Ala Pro Glu Asp Val Glu Thr Asn Cys Glu Trp Ser Ala Phe Ser Cys 
        35                  40                  45              


Phe Gln Lys Ala Gln Leu Lys Ser Ala Asn Thr Gly Asn Asn Glu Arg 
    50                  55                  60                  


Ile Ile Asn Val Ser Ile Lys Lys Leu Lys Arg Lys Pro Pro Ser Thr 
65                  70                  75                  80  


Asn Ala Gly Arg Arg Gln Lys His Arg Leu Thr Cys Pro Ser Cys Asp 
                85                  90                  95      


Ser Tyr Glu Lys Lys Pro Pro Lys Glu Phe Leu Glu Arg Phe Lys Ser 
            100                 105                 110         


Leu Leu Gln Lys Met Ile His Gln His Leu Ser Ser Arg Thr His Gly 
        115                 120                 125             


Ser Glu Asp Ser 
    130         


<210>  13
<211>  153
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic IL-2

<400>  13

Met Tyr Arg Met Gln Leu Leu Ser Cys Ile Ala Leu Ser Leu Ala Leu 
1               5                   10                  15      


Val Thr Asn Ser Ala Pro Thr Ser Ser Ser Thr Lys Lys Thr Gln Leu 
            20                  25                  30          


Gln Leu Glu His Leu Leu Leu Asp Leu Gln Met Ile Leu Asn Gly Ile 
        35                  40                  45              


Asn Asn Tyr Lys Asn Pro Lys Leu Thr Arg Met Leu Thr Phe Lys Phe 
    50                  55                  60                  


Tyr Met Pro Lys Lys Ala Thr Glu Leu Lys His Leu Gln Cys Leu Glu 
65                  70                  75                  80  


Glu Glu Leu Lys Pro Leu Glu Glu Val Leu Asn Leu Ala Gln Ser Lys 
                85                  90                  95      


Asn Phe His Leu Arg Pro Arg Asp Leu Ile Ser Asn Ile Asn Val Ile 
            100                 105                 110         


Val Leu Glu Leu Lys Gly Ser Glu Thr Thr Phe Met Cys Glu Tyr Ala 
        115                 120                 125             


Asp Glu Thr Ala Thr Ile Val Glu Phe Leu Asn Arg Trp Ile Thr Phe 
    130                 135                 140                 


Cys Gln Ser Ile Ile Ser Thr Leu Thr 
145                 150             


<210>  14
<211>  133
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic IL-2 mutein

<400>  14

Ala Pro Thr Ser Ser Ser Thr Lys Lys Thr Gln Leu Gln Leu Glu His 
1               5                   10                  15      


Leu Leu Leu Asp Leu Gln Met Ile Leu Asn Gly Ile Asn Asn Tyr Lys 
            20                  25                  30          


Asn Pro Lys Leu Thr Ala Met Leu Thr Phe Lys Phe Tyr Met Pro Lys 
        35                  40                  45              


Lys Ala Thr Glu Leu Lys His Leu Gln Cys Leu Glu Glu Glu Leu Lys 
    50                  55                  60                  


Pro Leu Glu Glu Val Leu Asn Leu Ala Gln Ser Lys Asn Phe His Leu 
65                  70                  75                  80  


Arg Pro Arg Asp Leu Ile Ser Asn Ile Asn Val Ile Val Leu Glu Leu 
                85                  90                  95      


Lys Gly Ser Glu Thr Thr Phe Met Cys Glu Tyr Ala Asp Glu Thr Ala 
            100                 105                 110         


Thr Ile Val Glu Phe Leu Asn Arg Trp Ile Thr Phe Cys Gln Ser Ile 
        115                 120                 125             


Ile Ser Thr Leu Thr 
    130             


<210>  15
<211>  133
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic IL-2 mutein

<400>  15

Ala Pro Thr Ser Ser Ser Thr Lys Lys Thr Gln Leu Gln Leu Glu His 
1               5                   10                  15      


Leu Leu Leu Asp Leu Gln Met Ile Leu Asn Gly Ile Asn Asn Tyr Lys 
            20                  25                  30          


Asn Pro Lys Leu Thr Arg Met Leu Thr Ala Lys Phe Tyr Met Pro Lys 
        35                  40                  45              


Lys Ala Thr Glu Leu Lys His Leu Gln Cys Leu Glu Glu Glu Leu Lys 
    50                  55                  60                  


Pro Leu Glu Glu Val Leu Asn Leu Ala Gln Ser Lys Asn Phe His Leu 
65                  70                  75                  80  


Arg Pro Arg Asp Leu Ile Ser Asn Ile Asn Val Ile Val Leu Glu Leu 
                85                  90                  95      


Lys Gly Ser Glu Thr Thr Phe Met Cys Glu Tyr Ala Asp Glu Thr Ala 
            100                 105                 110         


Thr Ile Val Glu Phe Leu Asn Arg Trp Ile Thr Phe Cys Gln Ser Ile 
        115                 120                 125             


Ile Ser Thr Leu Thr 
    130             


<210>  16
<211>  145
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic HCDR1_IL-2

<400>  16

Gly Phe Ser Leu Ala Pro Thr Ser Ser Ser Thr Lys Lys Thr Gln Leu 
1               5                   10                  15      


Gln Leu Glu His Leu Leu Leu Asp Leu Gln Met Ile Leu Asn Gly Ile 
            20                  25                  30          


Asn Asn Tyr Lys Asn Pro Lys Leu Thr Ala Met Leu Thr Phe Lys Phe 
        35                  40                  45              


Tyr Met Pro Lys Lys Ala Thr Glu Leu Lys His Leu Gln Cys Leu Glu 
    50                  55                  60                  


Glu Glu Leu Lys Pro Leu Glu Glu Val Leu Asn Leu Ala Gln Ser Lys 
65                  70                  75                  80  


Asn Phe His Leu Arg Pro Arg Asp Leu Ile Ser Asn Ile Asn Val Ile 
                85                  90                  95      


Val Leu Glu Leu Lys Gly Ser Glu Thr Thr Phe Met Cys Glu Tyr Ala 
            100                 105                 110         


Asp Glu Thr Ala Thr Ile Val Glu Phe Leu Asn Arg Trp Ile Thr Phe 
        115                 120                 125             


Cys Gln Ser Ile Ile Ser Thr Leu Thr Ser Thr Ser Gly Met Ser Val 
    130                 135                 140                 


Gly 
145 


<210>  17
<211>  16
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic HCDR2

<400>  17

Asp Ile Trp Trp Asp Asp Lys Lys Asp Tyr Asn Pro Ser Leu Lys Ser 
1               5                   10                  15      


<210>  18
<211>  10
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic HCDR3

<400>  18

Ser Met Ile Thr Asn Trp Tyr Phe Asp Val 
1               5                   10  


<210>  19
<211>  141
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic HCDR1_IL-2 kabat

<400>  19

Ala Pro Thr Ser Ser Ser Thr Lys Lys Thr Gln Leu Gln Leu Glu His 
1               5                   10                  15      


Leu Leu Leu Asp Leu Gln Met Ile Leu Asn Gly Ile Asn Asn Tyr Lys 
            20                  25                  30          


Asn Pro Lys Leu Thr Ala Met Leu Thr Phe Lys Phe Tyr Met Pro Lys 
        35                  40                  45              


Lys Ala Thr Glu Leu Lys His Leu Gln Cys Leu Glu Glu Glu Leu Lys 
    50                  55                  60                  


Pro Leu Glu Glu Val Leu Asn Leu Ala Gln Ser Lys Asn Phe His Leu 
65                  70                  75                  80  


Arg Pro Arg Asp Leu Ile Ser Asn Ile Asn Val Ile Val Leu Glu Leu 
                85                  90                  95      


Lys Gly Ser Glu Thr Thr Phe Met Cys Glu Tyr Ala Asp Glu Thr Ala 
            100                 105                 110         


Thr Ile Val Glu Phe Leu Asn Arg Trp Ile Thr Phe Cys Gln Ser Ile 
        115                 120                 125             


Ile Ser Thr Leu Thr Ser Thr Ser Gly Met Ser Val Gly 
    130                 135                 140     


<210>  20
<211>  16
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic HCDR2 kabat

<400>  20

Asp Ile Trp Trp Asp Asp Lys Lys Asp Tyr Asn Pro Ser Leu Lys Ser 
1               5                   10                  15      


<210>  21
<211>  10
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic HCDR3 kabat

<400>  21

Ser Met Ile Thr Asn Trp Tyr Phe Asp Val 
1               5                   10  


<210>  22
<211>  142
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic HCDR1_IL-2 clothia

<400>  22

Gly Phe Ser Leu Ala Pro Thr Ser Ser Ser Thr Lys Lys Thr Gln Leu 
1               5                   10                  15      


Gln Leu Glu His Leu Leu Leu Asp Leu Gln Met Ile Leu Asn Gly Ile 
            20                  25                  30          


Asn Asn Tyr Lys Asn Pro Lys Leu Thr Ala Met Leu Thr Phe Lys Phe 
        35                  40                  45              


Tyr Met Pro Lys Lys Ala Thr Glu Leu Lys His Leu Gln Cys Leu Glu 
    50                  55                  60                  


Glu Glu Leu Lys Pro Leu Glu Glu Val Leu Asn Leu Ala Gln Ser Lys 
65                  70                  75                  80  


Asn Phe His Leu Arg Pro Arg Asp Leu Ile Ser Asn Ile Asn Val Ile 
                85                  90                  95      


Val Leu Glu Leu Lys Gly Ser Glu Thr Thr Phe Met Cys Glu Tyr Ala 
            100                 105                 110         


Asp Glu Thr Ala Thr Ile Val Glu Phe Leu Asn Arg Trp Ile Thr Phe 
        115                 120                 125             


Cys Gln Ser Ile Ile Ser Thr Leu Thr Ser Thr Ser Gly Met 
    130                 135                 140         


<210>  23
<211>  5
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic HCDR2 clothia

<400>  23

Trp Trp Asp Asp Lys 
1               5   


<210>  24
<211>  10
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic HCDR3 clothia

<400>  24

Ser Met Ile Thr Asn Trp Tyr Phe Asp Val 
1               5                   10  


<210>  25
<211>  143
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic HCDR1_IL-2 IMGT

<400>  25

Gly Phe Ser Leu Ala Pro Thr Ser Ser Ser Thr Lys Lys Thr Gln Leu 
1               5                   10                  15      


Gln Leu Glu His Leu Leu Leu Asp Leu Gln Met Ile Leu Asn Gly Ile 
            20                  25                  30          


Asn Asn Tyr Lys Asn Pro Lys Leu Thr Ala Met Leu Thr Phe Lys Phe 
        35                  40                  45              


Tyr Met Pro Lys Lys Ala Thr Glu Leu Lys His Leu Gln Cys Leu Glu 
    50                  55                  60                  


Glu Glu Leu Lys Pro Leu Glu Glu Val Leu Asn Leu Ala Gln Ser Lys 
65                  70                  75                  80  


Asn Phe His Leu Arg Pro Arg Asp Leu Ile Ser Asn Ile Asn Val Ile 
                85                  90                  95      


Val Leu Glu Leu Lys Gly Ser Glu Thr Thr Phe Met Cys Glu Tyr Ala 
            100                 105                 110         


Asp Glu Thr Ala Thr Ile Val Glu Phe Leu Asn Arg Trp Ile Thr Phe 
        115                 120                 125             


Cys Gln Ser Ile Ile Ser Thr Leu Thr Ser Thr Ser Gly Met Ser 
    130                 135                 140             


<210>  26
<211>  7
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic HCDR2 IMGT

<400>  26

Ile Trp Trp Asp Asp Lys Lys 
1               5           


<210>  27
<211>  12
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic HCDR3 IMGT

<400>  27

Ala Arg Ser Met Ile Thr Asn Trp Tyr Phe Asp Val 
1               5                   10          


<210>  28
<211>  253
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic VH

<400>  28

Gln Val Thr Leu Arg Glu Ser Gly Pro Ala Leu Val Lys Pro Thr Gln 
1               5                   10                  15      


Thr Leu Thr Leu Thr Cys Thr Phe Ser Gly Phe Ser Leu Ala Pro Thr 
            20                  25                  30          


Ser Ser Ser Thr Lys Lys Thr Gln Leu Gln Leu Glu His Leu Leu Leu 
        35                  40                  45              


Asp Leu Gln Met Ile Leu Asn Gly Ile Asn Asn Tyr Lys Asn Pro Lys 
    50                  55                  60                  


Leu Thr Ala Met Leu Thr Phe Lys Phe Tyr Met Pro Lys Lys Ala Thr 
65                  70                  75                  80  


Glu Leu Lys His Leu Gln Cys Leu Glu Glu Glu Leu Lys Pro Leu Glu 
                85                  90                  95      


Glu Val Leu Asn Leu Ala Gln Ser Lys Asn Phe His Leu Arg Pro Arg 
            100                 105                 110         


Asp Leu Ile Ser Asn Ile Asn Val Ile Val Leu Glu Leu Lys Gly Ser 
        115                 120                 125             


Glu Thr Thr Phe Met Cys Glu Tyr Ala Asp Glu Thr Ala Thr Ile Val 
    130                 135                 140                 


Glu Phe Leu Asn Arg Trp Ile Thr Phe Cys Gln Ser Ile Ile Ser Thr 
145                 150                 155                 160 


Leu Thr Ser Thr Ser Gly Met Ser Val Gly Trp Ile Arg Gln Pro Pro 
                165                 170                 175     


Gly Lys Ala Leu Glu Trp Leu Ala Asp Ile Trp Trp Asp Asp Lys Lys 
            180                 185                 190         


Asp Tyr Asn Pro Ser Leu Lys Ser Arg Leu Thr Ile Ser Lys Asp Thr 
        195                 200                 205             


Ser Lys Asn Gln Val Val Leu Lys Val Thr Asn Met Asp Pro Ala Asp 
    210                 215                 220                 


Thr Ala Thr Tyr Tyr Cys Ala Arg Ser Met Ile Thr Asn Trp Tyr Phe 
225                 230                 235                 240 


Asp Val Trp Gly Ala Gly Thr Thr Val Thr Val Ser Ser 
                245                 250             


<210>  29
<211>  533
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic Heavy chain

<400>  29

Gln Met Ile Leu Asn Gly Ile Asn Asn Tyr Lys Asn Pro Lys Leu Thr 
1               5                   10                  15      


Ala Met Leu Thr Phe Lys Phe Tyr Met Pro Lys Lys Ala Thr Glu Leu 
            20                  25                  30          


Lys His Leu Gln Cys Leu Glu Glu Glu Leu Lys Pro Leu Glu Glu Val 
        35                  40                  45              


Leu Asn Leu Ala Gln Ser Lys Asn Phe His Leu Arg Pro Arg Asp Leu 
    50                  55                  60                  


Ile Ser Asn Ile Asn Val Ile Val Leu Glu Leu Lys Gly Ser Glu Thr 
65                  70                  75                  80  


Thr Phe Met Cys Glu Tyr Ala Asp Glu Thr Ala Thr Ile Val Glu Phe 
                85                  90                  95      


Leu Asn Arg Trp Ile Thr Phe Cys Gln Ser Ile Ile Ser Thr Leu Thr 
            100                 105                 110         


Ser Thr Ser Gly Met Ser Val Gly Trp Ile Arg Gln Pro Pro Gly Lys 
        115                 120                 125             


Ala Leu Glu Trp Leu Ala Asp Ile Trp Trp Asp Asp Lys Lys Asp Tyr 
    130                 135                 140                 


Asn Pro Ser Leu Lys Ser Arg Leu Thr Ile Ser Lys Asp Thr Ser Lys 
145                 150                 155                 160 


Asn Gln Val Val Leu Lys Val Thr Asn Met Asp Pro Ala Asp Thr Ala 
                165                 170                 175     


Thr Tyr Tyr Cys Ala Arg Ser Met Ile Thr Asn Trp Tyr Phe Asp Val 
            180                 185                 190         


Trp Gly Ala Gly Thr Thr Val Thr Val Ser Ser Ala Ser Thr Lys Gly 
        195                 200                 205             


Pro Ser Val Phe Pro Leu Ala Pro Ser Ser Lys Ser Thr Ser Gly Gly 
    210                 215                 220                 


Thr Ala Ala Leu Gly Cys Leu Val Lys Asp Tyr Phe Pro Glu Pro Val 
225                 230                 235                 240 


Thr Val Ser Trp Asn Ser Gly Ala Leu Thr Ser Gly Val His Thr Phe 
                245                 250                 255     


Pro Ala Val Leu Gln Ser Ser Gly Leu Tyr Ser Leu Ser Ser Val Val 
            260                 265                 270         


Thr Val Pro Ser Ser Ser Leu Gly Thr Gln Thr Tyr Ile Cys Asn Val 
        275                 280                 285             


Asn His Lys Pro Ser Asn Thr Lys Val Asp Lys Arg Val Glu Pro Lys 
    290                 295                 300                 


Ser Cys Asp Lys Thr His Thr Cys Pro Pro Cys Pro Ala Pro Glu Leu 
305                 310                 315                 320 


Leu Gly Gly Pro Ser Val Phe Leu Phe Pro Pro Lys Pro Lys Asp Thr 
                325                 330                 335     


Leu Met Ile Ser Arg Thr Pro Glu Val Thr Cys Val Val Val Ala Val 
            340                 345                 350         


Ser His Glu Asp Pro Glu Val Lys Phe Asn Trp Tyr Val Asp Gly Val 
        355                 360                 365             


Glu Val His Asn Ala Lys Thr Lys Pro Arg Glu Glu Gln Tyr Asn Ser 
    370                 375                 380                 


Thr Tyr Arg Val Val Ser Val Leu Thr Val Leu His Gln Asp Trp Leu 
385                 390                 395                 400 


Asn Gly Lys Glu Tyr Lys Cys Lys Val Ser Asn Lys Ala Leu Ala Ala 
                405                 410                 415     


Pro Ile Glu Lys Thr Ile Ser Lys Ala Lys Gly Gln Pro Arg Glu Pro 
            420                 425                 430         


Gln Val Tyr Thr Leu Pro Pro Ser Arg Glu Glu Met Thr Lys Asn Gln 
        435                 440                 445             


Val Ser Leu Thr Cys Leu Val Lys Gly Phe Tyr Pro Ser Asp Ile Ala 
    450                 455                 460                 


Val Glu Trp Glu Ser Asn Gly Gln Pro Glu Asn Asn Tyr Lys Thr Thr 
465                 470                 475                 480 


Pro Pro Val Leu Asp Ser Asp Gly Ser Phe Phe Leu Tyr Ser Lys Leu 
                485                 490                 495     


Thr Val Asp Lys Ser Arg Trp Gln Gln Gly Asn Val Phe Ser Cys Ser 
            500                 505                 510         


Val Met His Glu Ala Leu His Asn His Tyr Thr Gln Lys Ser Leu Ser 
        515                 520                 525             


Leu Ser Pro Gly Lys 
    530             


<210>  30
<211>  10
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic LCDR1 kabat

<400>  30

Lys Ala Gln Leu Ser Val Gly Tyr Met His 
1               5                   10  


<210>  31
<211>  7
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic LCDR2 kabat

<400>  31

Asp Thr Ser Lys Leu Ala Ser 
1               5           


<210>  32
<211>  9
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic LCDR3 kabat

<400>  32

Phe Gln Gly Ser Gly Tyr Pro Phe Thr 
1               5                   


<210>  33
<211>  6
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic LCDR1 chothia

<400>  33

Gln Leu Ser Val Gly Tyr 
1               5       


<210>  34
<211>  3
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic LCDR2 chothia

<400>  34

Asp Thr Ser 
1           


<210>  35
<211>  6
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic LCDR3 chothia

<400>  35

Gly Ser Gly Tyr Pro Phe 
1               5       


<210>  36
<211>  106
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic VL

<400>  36

Asp Ile Gln Met Thr Gln Ser Pro Ser Thr Leu Ser Ala Ser Val Gly 
1               5                   10                  15      


Asp Arg Val Thr Ile Thr Cys Lys Ala Gln Leu Ser Val Gly Tyr Met 
            20                  25                  30          


His Trp Tyr Gln Gln Lys Pro Gly Lys Ala Pro Lys Leu Leu Ile Tyr 
        35                  40                  45              


Asp Thr Ser Lys Leu Ala Ser Gly Val Pro Ser Arg Phe Ser Gly Ser 
    50                  55                  60                  


Gly Ser Gly Thr Glu Phe Thr Leu Thr Ile Ser Ser Leu Gln Pro Asp 
65                  70                  75                  80  


Asp Phe Ala Thr Tyr Tyr Cys Phe Gln Gly Ser Gly Tyr Pro Phe Thr 
                85                  90                  95      


Phe Gly Gly Gly Thr Lys Leu Glu Ile Lys 
            100                 105     


<210>  37
<211>  213
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic Light chain

<400>  37

Asp Ile Gln Met Thr Gln Ser Pro Ser Thr Leu Ser Ala Ser Val Gly 
1               5                   10                  15      


Asp Arg Val Thr Ile Thr Cys Lys Ala Gln Leu Ser Val Gly Tyr Met 
            20                  25                  30          


His Trp Tyr Gln Gln Lys Pro Gly Lys Ala Pro Lys Leu Leu Ile Tyr 
        35                  40                  45              


Asp Thr Ser Lys Leu Ala Ser Gly Val Pro Ser Arg Phe Ser Gly Ser 
    50                  55                  60                  


Gly Ser Gly Thr Glu Phe Thr Leu Thr Ile Ser Ser Leu Gln Pro Asp 
65                  70                  75                  80  


Asp Phe Ala Thr Tyr Tyr Cys Phe Gln Gly Ser Gly Tyr Pro Phe Thr 
                85                  90                  95      


Phe Gly Gly Gly Thr Lys Leu Glu Ile Lys Arg Thr Val Ala Ala Pro 
            100                 105                 110         


Ser Val Phe Ile Phe Pro Pro Ser Asp Glu Gln Leu Lys Ser Gly Thr 
        115                 120                 125             


Ala Ser Val Val Cys Leu Leu Asn Asn Phe Tyr Pro Arg Glu Ala Lys 
    130                 135                 140                 


Val Gln Trp Lys Val Asp Asn Ala Leu Gln Ser Gly Asn Ser Gln Glu 
145                 150                 155                 160 


Ser Val Thr Glu Gln Asp Ser Lys Asp Ser Thr Tyr Ser Leu Ser Ser 
                165                 170                 175     


Thr Leu Thr Leu Ser Lys Ala Asp Tyr Glu Lys His Lys Val Tyr Ala 
            180                 185                 190         


Cys Glu Val Thr His Gln Gly Leu Ser Ser Pro Val Thr Lys Ser Phe 
        195                 200                 205             


Asn Arg Gly Glu Cys 
    210             


<210>  38
<211>  583
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic Light chain

<400>  38

Gln Val Thr Leu Arg Glu Ser Gly Pro Ala Leu Val Lys Pro Thr Gln 
1               5                   10                  15      


Thr Leu Thr Leu Thr Cys Thr Phe Ser Gly Phe Ser Leu Ala Pro Thr 
            20                  25                  30          


Ser Ser Ser Thr Lys Lys Thr Gln Leu Gln Leu Glu His Leu Leu Leu 
        35                  40                  45              


Asp Leu Gln Met Ile Leu Asn Gly Ile Asn Asn Tyr Lys Asn Pro Lys 
    50                  55                  60                  


Leu Thr Arg Met Leu Thr Ala Lys Phe Tyr Met Pro Lys Lys Ala Thr 
65                  70                  75                  80  


Glu Leu Lys His Leu Gln Cys Leu Glu Glu Glu Leu Lys Pro Leu Glu 
                85                  90                  95      


Glu Val Leu Asn Leu Ala Gln Ser Lys Asn Phe His Leu Arg Pro Arg 
            100                 105                 110         


Asp Leu Ile Ser Asn Ile Asn Val Ile Val Leu Glu Leu Lys Gly Ser 
        115                 120                 125             


Glu Thr Thr Phe Met Cys Glu Tyr Ala Asp Glu Thr Ala Thr Ile Val 
    130                 135                 140                 


Glu Phe Leu Asn Arg Trp Ile Thr Phe Cys Gln Ser Ile Ile Ser Thr 
145                 150                 155                 160 


Leu Thr Ser Thr Ser Gly Met Ser Val Gly Trp Ile Arg Gln Pro Pro 
                165                 170                 175     


Gly Lys Ala Leu Glu Trp Leu Ala Asp Ile Trp Trp Asp Asp Lys Lys 
            180                 185                 190         


Asp Tyr Asn Pro Ser Leu Lys Ser Arg Leu Thr Ile Ser Lys Asp Thr 
        195                 200                 205             


Ser Lys Asn Gln Val Val Leu Lys Val Thr Asn Met Asp Pro Ala Asp 
    210                 215                 220                 


Thr Ala Thr Tyr Tyr Cys Ala Arg Ser Met Ile Thr Asn Trp Tyr Phe 
225                 230                 235                 240 


Asp Val Trp Gly Ala Gly Thr Thr Val Thr Val Ser Ser Ala Ser Thr 
                245                 250                 255     


Lys Gly Pro Ser Val Phe Pro Leu Ala Pro Ser Ser Lys Ser Thr Ser 
            260                 265                 270         


Gly Gly Thr Ala Ala Leu Gly Cys Leu Val Lys Asp Tyr Phe Pro Glu 
        275                 280                 285             


Pro Val Thr Val Ser Trp Asn Ser Gly Ala Leu Thr Ser Gly Val His 
    290                 295                 300                 


Thr Phe Pro Ala Val Leu Gln Ser Ser Gly Leu Tyr Ser Leu Ser Ser 
305                 310                 315                 320 


Val Val Thr Val Pro Ser Ser Ser Leu Gly Thr Gln Thr Tyr Ile Cys 
                325                 330                 335     


Asn Val Asn His Lys Pro Ser Asn Thr Lys Val Asp Lys Arg Val Glu 
            340                 345                 350         


Pro Lys Ser Cys Asp Lys Thr His Thr Cys Pro Pro Cys Pro Ala Pro 
        355                 360                 365             


Glu Leu Leu Gly Gly Pro Ser Val Phe Leu Phe Pro Pro Lys Pro Lys 
    370                 375                 380                 


Asp Thr Leu Met Ile Ser Arg Thr Pro Glu Val Thr Cys Val Val Val 
385                 390                 395                 400 


Ala Val Ser His Glu Asp Pro Glu Val Lys Phe Asn Trp Tyr Val Asp 
                405                 410                 415     


Gly Val Glu Val His Asn Ala Lys Thr Lys Pro Arg Glu Glu Gln Tyr 
            420                 425                 430         


Asn Ser Thr Tyr Arg Val Val Ser Val Leu Thr Val Leu His Gln Asp 
        435                 440                 445             


Trp Leu Asn Gly Lys Glu Tyr Lys Cys Lys Val Ser Asn Lys Ala Leu 
    450                 455                 460                 


Ala Ala Pro Ile Glu Lys Thr Ile Ser Lys Ala Lys Gly Gln Pro Arg 
465                 470                 475                 480 


Glu Pro Gln Val Tyr Thr Leu Pro Pro Ser Arg Glu Glu Met Thr Lys 
                485                 490                 495     


Asn Gln Val Ser Leu Thr Cys Leu Val Lys Gly Phe Tyr Pro Ser Asp 
            500                 505                 510         


Ile Ala Val Glu Trp Glu Ser Asn Gly Gln Pro Glu Asn Asn Tyr Lys 
        515                 520                 525             


Thr Thr Pro Pro Val Leu Asp Ser Asp Gly Ser Phe Phe Leu Tyr Ser 
    530                 535                 540                 


Lys Leu Thr Val Asp Lys Ser Arg Trp Gln Gln Gly Asn Val Phe Ser 
545                 550                 555                 560 


Cys Ser Val Met His Glu Ala Leu His Asn His Tyr Thr Gln Lys Ser 
                565                 570                 575     


Leu Ser Leu Ser Pro Gly Lys 
            580             


<210>  39
<211>  213
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic Light chain

<400>  39

Asp Ile Gln Met Thr Gln Ser Pro Ser Thr Leu Ser Ala Ser Val Gly 
1               5                   10                  15      


Asp Arg Val Thr Ile Thr Cys Lys Ala Gln Leu Ser Val Gly Tyr Met 
            20                  25                  30          


His Trp Tyr Gln Gln Lys Pro Gly Lys Ala Pro Lys Leu Leu Ile Tyr 
        35                  40                  45              


Asp Thr Ser Lys Leu Ala Ser Gly Val Pro Ser Arg Phe Ser Gly Ser 
    50                  55                  60                  


Gly Ser Gly Thr Glu Phe Thr Leu Thr Ile Ser Ser Leu Gln Pro Asp 
65                  70                  75                  80  


Asp Phe Ala Thr Tyr Tyr Cys Phe Gln Gly Ser Gly Tyr Pro Phe Thr 
                85                  90                  95      


Phe Gly Gly Gly Thr Lys Leu Glu Ile Lys Arg Thr Val Ala Ala Pro 
            100                 105                 110         


Ser Val Phe Ile Phe Pro Pro Ser Asp Glu Gln Leu Lys Ser Gly Thr 
        115                 120                 125             


Ala Ser Val Val Cys Leu Leu Asn Asn Phe Tyr Pro Arg Glu Ala Lys 
    130                 135                 140                 


Val Gln Trp Lys Val Asp Asn Ala Leu Gln Ser Gly Asn Ser Gln Glu 
145                 150                 155                 160 


Ser Val Thr Glu Gln Asp Ser Lys Asp Ser Thr Tyr Ser Leu Ser Ser 
                165                 170                 175     


Thr Leu Thr Leu Ser Lys Ala Asp Tyr Glu Lys His Lys Val Tyr Ala 
            180                 185                 190         


Cys Glu Val Thr His Gln Gly Leu Ser Ser Pro Val Thr Lys Ser Phe 
        195                 200                 205             


Asn Arg Gly Glu Cys 
    210             


<210>  40
<211>  255
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic human 4-1BB, Tumor necrosis factor receptor 
       superfamily, member 9 (Homo sapiens)

<400>  40

Met Gly Asn Ser Cys Tyr Asn Ile Val Ala Thr Leu Leu Leu Val Leu 
1               5                   10                  15      


Asn Phe Glu Arg Thr Arg Ser Leu Gln Asp Pro Cys Ser Asn Cys Pro 
            20                  25                  30          


Ala Gly Thr Phe Cys Asp Asn Asn Arg Asn Gln Ile Cys Ser Pro Cys 
        35                  40                  45              


Pro Pro Asn Ser Phe Ser Ser Ala Gly Gly Gln Arg Thr Cys Asp Ile 
    50                  55                  60                  


Cys Arg Gln Cys Lys Gly Val Phe Arg Thr Arg Lys Glu Cys Ser Ser 
65                  70                  75                  80  


Thr Ser Asn Ala Glu Cys Asp Cys Thr Pro Gly Phe His Cys Leu Gly 
                85                  90                  95      


Ala Gly Cys Ser Met Cys Glu Gln Asp Cys Lys Gln Gly Gln Glu Leu 
            100                 105                 110         


Thr Lys Lys Gly Cys Lys Asp Cys Cys Phe Gly Thr Phe Asn Asp Gln 
        115                 120                 125             


Lys Arg Gly Ile Cys Arg Pro Trp Thr Asn Cys Ser Leu Asp Gly Lys 
    130                 135                 140                 


Ser Val Leu Val Asn Gly Thr Lys Glu Arg Asp Val Val Cys Gly Pro 
145                 150                 155                 160 


Ser Pro Ala Asp Leu Ser Pro Gly Ala Ser Ser Val Thr Pro Pro Ala 
                165                 170                 175     


Pro Ala Arg Glu Pro Gly His Ser Pro Gln Ile Ile Ser Phe Phe Leu 
            180                 185                 190         


Ala Leu Thr Ser Thr Ala Leu Leu Phe Leu Leu Phe Phe Leu Thr Leu 
        195                 200                 205             


Arg Phe Ser Val Val Lys Arg Gly Arg Lys Lys Leu Leu Tyr Ile Phe 
    210                 215                 220                 


Lys Gln Pro Phe Met Arg Pro Val Gln Thr Thr Gln Glu Glu Asp Gly 
225                 230                 235                 240 


Cys Ser Cys Arg Phe Pro Glu Glu Glu Glu Gly Gly Cys Glu Leu 
                245                 250                 255 


<210>  41
<211>  256
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic murine 4-1BB, Tumor necrosis factor receptor 
       superfamily, member 9 (Mus musculus)

<400>  41

Met Gly Asn Asn Cys Tyr Asn Val Val Val Ile Val Leu Leu Leu Val 
1               5                   10                  15      


Gly Cys Glu Lys Val Gly Ala Val Gln Asn Ser Cys Asp Asn Cys Gln 
            20                  25                  30          


Pro Gly Thr Phe Cys Arg Lys Tyr Asn Pro Val Cys Lys Ser Cys Pro 
        35                  40                  45              


Pro Ser Thr Phe Ser Ser Ile Gly Gly Gln Pro Asn Cys Asn Ile Cys 
    50                  55                  60                  


Arg Val Cys Ala Gly Tyr Phe Arg Phe Lys Lys Phe Cys Ser Ser Thr 
65                  70                  75                  80  


His Asn Ala Glu Cys Glu Cys Ile Glu Gly Phe His Cys Leu Gly Pro 
                85                  90                  95      


Gln Cys Thr Arg Cys Glu Lys Asp Cys Arg Pro Gly Gln Glu Leu Thr 
            100                 105                 110         


Lys Gln Gly Cys Lys Thr Cys Ser Leu Gly Thr Phe Asn Asp Gln Asn 
        115                 120                 125             


Gly Thr Gly Val Cys Arg Pro Trp Thr Asn Cys Ser Leu Asp Gly Arg 
    130                 135                 140                 


Ser Val Leu Lys Thr Gly Thr Thr Glu Lys Asp Val Val Cys Gly Pro 
145                 150                 155                 160 


Pro Val Val Ser Phe Ser Pro Ser Thr Thr Ile Ser Val Thr Pro Glu 
                165                 170                 175     


Gly Gly Pro Gly Gly His Ser Leu Gln Val Leu Thr Leu Phe Leu Ala 
            180                 185                 190         


Leu Thr Ser Ala Leu Leu Leu Ala Leu Ile Phe Ile Thr Leu Leu Phe 
        195                 200                 205             


Ser Val Leu Lys Trp Ile Arg Lys Lys Phe Pro His Ile Phe Lys Gln 
    210                 215                 220                 


Pro Phe Lys Lys Thr Thr Gly Ala Ala Gln Glu Glu Asp Ala Cys Ser 
225                 230                 235                 240 


Cys Arg Cys Pro Gln Glu Glu Glu Gly Gly Gly Gly Gly Tyr Glu Leu 
                245                 250                 255     


<210>  42
<211>  441
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic heavy chain for utomilumab

<400>  42

Glu Val Gln Leu Val Gln Ser Gly Ala Glu Val Lys Lys Pro Gly Glu 
1               5                   10                  15      


Ser Leu Arg Ile Ser Cys Lys Gly Ser Gly Tyr Ser Phe Ser Thr Tyr 
            20                  25                  30          


Trp Ile Ser Trp Val Arg Gln Met Pro Gly Lys Gly Leu Glu Trp Met 
        35                  40                  45              


Gly Lys Ile Tyr Pro Gly Asp Ser Tyr Thr Asn Tyr Ser Pro Ser Phe 
    50                  55                  60                  


Gln Gly Gln Val Thr Ile Ser Ala Asp Lys Ser Ile Ser Thr Ala Tyr 
65                  70                  75                  80  


Leu Gln Trp Ser Ser Leu Lys Ala Ser Asp Thr Ala Met Tyr Tyr Cys 
                85                  90                  95      


Ala Arg Gly Tyr Gly Ile Phe Asp Tyr Trp Gly Gln Gly Thr Leu Val 
            100                 105                 110         


Thr Val Ser Ser Ala Ser Thr Lys Gly Pro Ser Val Phe Pro Leu Ala 
        115                 120                 125             


Pro Cys Ser Arg Ser Thr Ser Glu Ser Thr Ala Ala Leu Gly Cys Leu 
    130                 135                 140                 


Val Lys Asp Tyr Phe Pro Glu Pro Val Thr Val Ser Trp Asn Ser Gly 
145                 150                 155                 160 


Ala Leu Thr Ser Gly Val His Thr Phe Pro Ala Val Leu Gln Ser Ser 
                165                 170                 175     


Gly Leu Tyr Ser Leu Ser Ser Val Val Thr Val Pro Ser Ser Asn Phe 
            180                 185                 190         


Gly Thr Gln Thr Tyr Thr Cys Asn Val Asp His Lys Pro Ser Asn Thr 
        195                 200                 205             


Lys Val Asp Lys Thr Val Glu Arg Lys Cys Cys Val Glu Cys Pro Pro 
    210                 215                 220                 


Cys Pro Ala Pro Pro Val Ala Gly Pro Ser Val Phe Leu Phe Pro Pro 
225                 230                 235                 240 


Lys Pro Lys Asp Thr Leu Met Ile Ser Arg Thr Pro Glu Val Thr Cys 
                245                 250                 255     


Val Val Val Asp Val Ser His Glu Asp Pro Glu Val Gln Phe Asn Trp 
            260                 265                 270         


Tyr Val Asp Gly Val Glu Val His Asn Ala Lys Thr Lys Pro Arg Glu 
        275                 280                 285             


Glu Gln Phe Asn Ser Thr Phe Arg Val Val Ser Val Leu Thr Val Val 
    290                 295                 300                 


His Gln Asp Trp Leu Asn Gly Lys Glu Tyr Lys Cys Lys Val Ser Asn 
305                 310                 315                 320 


Lys Gly Leu Pro Ala Pro Ile Glu Lys Thr Ile Ser Lys Thr Lys Gly 
                325                 330                 335     


Gln Pro Arg Glu Pro Gln Val Tyr Thr Leu Pro Pro Ser Arg Glu Glu 
            340                 345                 350         


Met Thr Lys Asn Gln Val Ser Leu Thr Cys Leu Val Lys Gly Phe Tyr 
        355                 360                 365             


Pro Ser Asp Ile Ala Val Glu Trp Glu Ser Asn Gly Gln Pro Glu Asn 
    370                 375                 380                 


Asn Tyr Lys Thr Thr Pro Pro Met Leu Asp Ser Asp Gly Ser Phe Phe 
385                 390                 395                 400 


Leu Tyr Ser Lys Leu Thr Val Asp Lys Ser Arg Trp Gln Gln Gly Asn 
                405                 410                 415     


Val Phe Ser Cys Ser Val Met His Glu Ala Leu His Asn His Tyr Thr 
            420                 425                 430         


Gln Lys Ser Leu Ser Leu Ser Pro Gly 
        435                 440     


<210>  43
<211>  214
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic light chain for utomilumab

<400>  43

Ser Tyr Glu Leu Thr Gln Pro Pro Ser Val Ser Val Ser Pro Gly Gln 
1               5                   10                  15      


Thr Ala Ser Ile Thr Cys Ser Gly Asp Asn Ile Gly Asp Gln Tyr Ala 
            20                  25                  30          


His Trp Tyr Gln Gln Lys Pro Gly Gln Ser Pro Val Leu Val Ile Tyr 
        35                  40                  45              


Gln Asp Lys Asn Arg Pro Ser Gly Ile Pro Glu Arg Phe Ser Gly Ser 
    50                  55                  60                  


Asn Ser Gly Asn Thr Ala Thr Leu Thr Ile Ser Gly Thr Gln Ala Met 
65                  70                  75                  80  


Asp Glu Ala Asp Tyr Tyr Cys Ala Thr Tyr Thr Gly Phe Gly Ser Leu 
                85                  90                  95      


Ala Val Phe Gly Gly Gly Thr Lys Leu Thr Val Leu Gly Gln Pro Lys 
            100                 105                 110         


Ala Ala Pro Ser Val Thr Leu Phe Pro Pro Ser Ser Glu Glu Leu Gln 
        115                 120                 125             


Ala Asn Lys Ala Thr Leu Val Cys Leu Ile Ser Asp Phe Tyr Pro Gly 
    130                 135                 140                 


Ala Val Thr Val Ala Trp Lys Ala Asp Ser Ser Pro Val Lys Ala Gly 
145                 150                 155                 160 


Val Glu Thr Thr Thr Pro Ser Lys Gln Ser Asn Asn Lys Tyr Ala Ala 
                165                 170                 175     


Ser Ser Tyr Leu Ser Leu Thr Pro Glu Gln Trp Lys Ser His Arg Ser 
            180                 185                 190         


Tyr Ser Cys Gln Val Thr His Glu Gly Ser Thr Val Glu Lys Thr Val 
        195                 200                 205             


Ala Pro Thr Glu Cys Ser 
    210                 


<210>  44
<211>  116
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic heavy chain variable region for utomilumab

<400>  44

Glu Val Gln Leu Val Gln Ser Gly Ala Glu Val Lys Lys Pro Gly Glu 
1               5                   10                  15      


Ser Leu Arg Ile Ser Cys Lys Gly Ser Gly Tyr Ser Phe Ser Thr Tyr 
            20                  25                  30          


Trp Ile Ser Trp Val Arg Gln Met Pro Gly Lys Gly Leu Glu Trp Met 
        35                  40                  45              


Gly Lys Ile Tyr Pro Gly Asp Ser Tyr Thr Asn Tyr Ser Pro Ser Phe 
    50                  55                  60                  


Gln Gly Gln Val Thr Ile Ser Ala Asp Lys Ser Ile Ser Thr Ala Tyr 
65                  70                  75                  80  


Leu Gln Trp Ser Ser Leu Lys Ala Ser Asp Thr Ala Met Tyr Tyr Cys 
                85                  90                  95      


Ala Arg Gly Tyr Gly Ile Phe Asp Tyr Trp Gly Gln Gly Thr Leu Val 
            100                 105                 110         


Thr Val Ser Ser 
        115     


<210>  45
<211>  108
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic light chain variable region for utomilumab

<400>  45

Ser Tyr Glu Leu Thr Gln Pro Pro Ser Val Ser Val Ser Pro Gly Gln 
1               5                   10                  15      


Thr Ala Ser Ile Thr Cys Ser Gly Asp Asn Ile Gly Asp Gln Tyr Ala 
            20                  25                  30          


His Trp Tyr Gln Gln Lys Pro Gly Gln Ser Pro Val Leu Val Ile Tyr 
        35                  40                  45              


Gln Asp Lys Asn Arg Pro Ser Gly Ile Pro Glu Arg Phe Ser Gly Ser 
    50                  55                  60                  


Asn Ser Gly Asn Thr Ala Thr Leu Thr Ile Ser Gly Thr Gln Ala Met 
65                  70                  75                  80  


Asp Glu Ala Asp Tyr Tyr Cys Ala Thr Tyr Thr Gly Phe Gly Ser Leu 
                85                  90                  95      


Ala Val Phe Gly Gly Gly Thr Lys Leu Thr Val Leu 
            100                 105             


<210>  46
<211>  6
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic heavy chain CDR1 for utomilumab

<400>  46

Ser Thr Tyr Trp Ile Ser 
1               5       


<210>  47
<211>  17
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic heavy chain CDR2 for utomilumab

<400>  47

Lys Ile Tyr Pro Gly Asp Ser Tyr Thr Asn Tyr Ser Pro Ser Phe Gln 
1               5                   10                  15      


Gly 
    


<210>  48
<211>  8
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic heavy chain CDR3 for utomilumab

<400>  48

Arg Gly Tyr Gly Ile Phe Asp Tyr 
1               5               


<210>  49
<211>  11
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic light chain CDR1 for utomilumab

<400>  49

Ser Gly Asp Asn Ile Gly Asp Gln Tyr Ala His 
1               5                   10      


<210>  50
<211>  7
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic light chain CDR2 for utomilumab

<400>  50

Gln Asp Lys Asn Arg Pro Ser 
1               5           


<210>  51
<211>  11
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic light chain CDR3 for utomilumab

<400>  51

Ala Thr Tyr Thr Gly Phe Gly Ser Leu Ala Val 
1               5                   10      


<210>  52
<211>  448
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic heavy chain for urelumab

<400>  52

Gln Val Gln Leu Gln Gln Trp Gly Ala Gly Leu Leu Lys Pro Ser Glu 
1               5                   10                  15      


Thr Leu Ser Leu Thr Cys Ala Val Tyr Gly Gly Ser Phe Ser Gly Tyr 
            20                  25                  30          


Tyr Trp Ser Trp Ile Arg Gln Ser Pro Glu Lys Gly Leu Glu Trp Ile 
        35                  40                  45              


Gly Glu Ile Asn His Gly Gly Tyr Val Thr Tyr Asn Pro Ser Leu Glu 
    50                  55                  60                  


Ser Arg Val Thr Ile Ser Val Asp Thr Ser Lys Asn Gln Phe Ser Leu 
65                  70                  75                  80  


Lys Leu Ser Ser Val Thr Ala Ala Asp Thr Ala Val Tyr Tyr Cys Ala 
                85                  90                  95      


Arg Asp Tyr Gly Pro Gly Asn Tyr Asp Trp Tyr Phe Asp Leu Trp Gly 
            100                 105                 110         


Arg Gly Thr Leu Val Thr Val Ser Ser Ala Ser Thr Lys Gly Pro Ser 
        115                 120                 125             


Val Phe Pro Leu Ala Pro Cys Ser Arg Ser Thr Ser Glu Ser Thr Ala 
    130                 135                 140                 


Ala Leu Gly Cys Leu Val Lys Asp Tyr Phe Pro Glu Pro Val Thr Val 
145                 150                 155                 160 


Ser Trp Asn Ser Gly Ala Leu Thr Ser Gly Val His Thr Phe Pro Ala 
                165                 170                 175     


Val Leu Gln Ser Ser Gly Leu Tyr Ser Leu Ser Ser Val Val Thr Val 
            180                 185                 190         


Pro Ser Ser Ser Leu Gly Thr Lys Thr Tyr Thr Cys Asn Val Asp His 
        195                 200                 205             


Lys Pro Ser Asn Thr Lys Val Asp Lys Arg Val Glu Ser Lys Tyr Gly 
    210                 215                 220                 


Pro Pro Cys Pro Pro Cys Pro Ala Pro Glu Phe Leu Gly Gly Pro Ser 
225                 230                 235                 240 


Val Phe Leu Phe Pro Pro Lys Pro Lys Asp Thr Leu Met Ile Ser Arg 
                245                 250                 255     


Thr Pro Glu Val Thr Cys Val Val Val Asp Val Ser Gln Glu Asp Pro 
            260                 265                 270         


Glu Val Gln Phe Asn Trp Tyr Val Asp Gly Val Glu Val His Asn Ala 
        275                 280                 285             


Lys Thr Lys Pro Arg Glu Glu Gln Phe Asn Ser Thr Tyr Arg Val Val 
    290                 295                 300                 


Ser Val Leu Thr Val Leu His Gln Asp Trp Leu Asn Gly Lys Glu Tyr 
305                 310                 315                 320 


Lys Cys Lys Val Ser Asn Lys Gly Leu Pro Ser Ser Ile Glu Lys Thr 
                325                 330                 335     


Ile Ser Lys Ala Lys Gly Gln Pro Arg Glu Pro Gln Val Tyr Thr Leu 
            340                 345                 350         


Pro Pro Ser Gln Glu Glu Met Thr Lys Asn Gln Val Ser Leu Thr Cys 
        355                 360                 365             


Leu Val Lys Gly Phe Tyr Pro Ser Asp Ile Ala Val Glu Trp Glu Ser 
    370                 375                 380                 


Asn Gly Gln Pro Glu Asn Asn Tyr Lys Thr Thr Pro Pro Val Leu Asp 
385                 390                 395                 400 


Ser Asp Gly Ser Phe Phe Leu Tyr Ser Arg Leu Thr Val Asp Lys Ser 
                405                 410                 415     


Arg Trp Gln Glu Gly Asn Val Phe Ser Cys Ser Val Met His Glu Ala 
            420                 425                 430         


Leu His Asn His Tyr Thr Gln Lys Ser Leu Ser Leu Ser Leu Gly Lys 
        435                 440                 445             


<210>  53
<211>  216
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic light chain for urelumab

<400>  53

Glu Ile Val Leu Thr Gln Ser Pro Ala Thr Leu Ser Leu Ser Pro Gly 
1               5                   10                  15      


Glu Arg Ala Thr Leu Ser Cys Arg Ala Ser Gln Ser Val Ser Ser Tyr 
            20                  25                  30          


Leu Ala Trp Tyr Gln Gln Lys Pro Gly Gln Ala Pro Arg Leu Leu Ile 
        35                  40                  45              


Tyr Asp Ala Ser Asn Arg Ala Thr Gly Ile Pro Ala Arg Phe Ser Gly 
    50                  55                  60                  


Ser Gly Ser Gly Thr Asp Phe Thr Leu Thr Ile Ser Ser Leu Glu Pro 
65                  70                  75                  80  


Glu Asp Phe Ala Val Tyr Tyr Cys Gln Gln Arg Ser Asn Trp Pro Pro 
                85                  90                  95      


Ala Leu Thr Phe Cys Gly Gly Thr Lys Val Glu Ile Lys Arg Thr Val 
            100                 105                 110         


Ala Ala Pro Ser Val Phe Ile Phe Pro Pro Ser Asp Glu Gln Leu Lys 
        115                 120                 125             


Ser Gly Thr Ala Ser Val Val Cys Leu Leu Asn Asn Phe Tyr Pro Arg 
    130                 135                 140                 


Glu Ala Lys Val Gln Trp Lys Val Asp Asn Ala Leu Gln Ser Gly Asn 
145                 150                 155                 160 


Ser Gln Glu Ser Val Thr Glu Gln Asp Ser Lys Asp Ser Thr Tyr Ser 
                165                 170                 175     


Leu Ser Ser Thr Leu Thr Leu Ser Lys Ala Asp Tyr Glu Lys His Lys 
            180                 185                 190         


Val Tyr Ala Cys Glu Val Thr His Gln Gly Leu Ser Ser Pro Val Thr 
        195                 200                 205             


Lys Ser Phe Asn Arg Gly Glu Cys 
    210                 215     


<210>  54
<211>  120
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic variable heavy chain for urelumab

<400>  54

Met Lys His Leu Trp Phe Phe Leu Leu Leu Val Ala Ala Pro Arg Trp 
1               5                   10                  15      


Val Leu Ser Gln Val Gln Leu Gln Gln Trp Gly Ala Gly Leu Leu Lys 
            20                  25                  30          


Pro Ser Glu Thr Leu Ser Leu Thr Cys Ala Val Tyr Gly Gly Ser Phe 
        35                  40                  45              


Ser Gly Tyr Tyr Trp Ser Trp Ile Arg Gln Ser Pro Glu Lys Gly Leu 
    50                  55                  60                  


Glu Trp Ile Gly Glu Ile Asn His Gly Gly Tyr Val Thr Tyr Asn Pro 
65                  70                  75                  80  


Ser Leu Glu Ser Arg Val Thr Ile Ser Val Asp Thr Ser Lys Asn Gln 
                85                  90                  95      


Phe Ser Leu Lys Leu Ser Ser Val Thr Ala Ala Asp Thr Ala Val Tyr 
            100                 105                 110         


Tyr Cys Ala Arg Asp Tyr Gly Pro 
        115                 120 


<210>  55
<211>  110
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic variable light chain for urelumab

<400>  55

Met Glu Ala Pro Ala Gln Leu Leu Phe Leu Leu Leu Leu Trp Leu Pro 
1               5                   10                  15      


Asp Thr Thr Gly Glu Ile Val Leu Thr Gln Ser Pro Ala Thr Leu Ser 
            20                  25                  30          


Leu Ser Pro Gly Glu Arg Ala Thr Leu Ser Cys Arg Ala Ser Gln Ser 
        35                  40                  45              


Val Ser Ser Tyr Leu Ala Trp Tyr Gln Gln Lys Pro Gly Gln Ala Pro 
    50                  55                  60                  


Arg Leu Leu Ile Tyr Asp Ala Ser Asn Arg Ala Thr Gly Ile Pro Ala 
65                  70                  75                  80  


Arg Phe Ser Gly Ser Gly Ser Gly Thr Asp Phe Thr Leu Thr Ile Ser 
                85                  90                  95      


Ser Leu Glu Pro Glu Asp Phe Ala Val Tyr Tyr Cys Gln Gln 
            100                 105                 110 


<210>  56
<211>  5
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic heavy chain CDR1 for urelumab

<400>  56

Gly Tyr Tyr Trp Ser 
1               5   


<210>  57
<211>  16
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic heavy chain CDR2 for urelumab

<400>  57

Glu Ile Asn His Gly Gly Tyr Val Thr Tyr Asn Pro Ser Leu Glu Ser 
1               5                   10                  15      


<210>  58
<211>  13
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic heavy chain CDR3 for urelumab

<400>  58

Asp Tyr Gly Pro Gly Asn Tyr Asp Trp Tyr Phe Asp Leu 
1               5                   10              


<210>  59
<211>  11
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic light chain CDR1 for urelumab

<400>  59

Arg Ala Ser Gln Ser Val Ser Ser Tyr Leu Ala 
1               5                   10      


<210>  60
<211>  7
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic light chain CDR2 for urelumab

<400>  60

Asp Ala Ser Asn Arg Ala Thr 
1               5           


<210>  61
<211>  11
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic light chain CDR3 for urelumab

<400>  61

Gln Gln Arg Ser Asp Trp Pro Pro Ala Leu Thr 
1               5                   10      


<210>  62
<211>  230
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic Fc domain

<400>  62

Lys Ser Cys Asp Lys Thr His Thr Cys Pro Pro Cys Pro Ala Pro Glu 
1               5                   10                  15      


Leu Leu Gly Gly Pro Ser Val Phe Leu Phe Pro Pro Lys Pro Lys Asp 
            20                  25                  30          


Thr Leu Met Ile Ser Arg Thr Pro Glu Val Thr Cys Val Val Val Asp 
        35                  40                  45              


Val Ser His Glu Asp Pro Glu Val Lys Phe Asn Trp Tyr Val Asp Gly 
    50                  55                  60                  


Val Glu Val His Asn Ala Lys Thr Lys Pro Arg Glu Glu Gln Tyr Asn 
65                  70                  75                  80  


Ser Thr Tyr Arg Val Val Ser Val Leu Thr Val Leu His Gln Asp Trp 
                85                  90                  95      


Leu Asn Gly Lys Glu Tyr Lys Cys Lys Val Ser Asn Lys Ala Leu Pro 
            100                 105                 110         


Ala Pro Ile Glu Lys Thr Ile Ser Lys Ala Lys Gly Gln Pro Arg Glu 
        115                 120                 125             


Pro Gln Val Tyr Thr Leu Pro Pro Ser Arg Glu Glu Met Thr Lys Asn 
    130                 135                 140                 


Gln Val Ser Leu Thr Cys Leu Val Lys Gly Phe Tyr Pro Ser Asp Ile 
145                 150                 155                 160 


Ala Val Glu Trp Glu Ser Asn Gly Gln Pro Glu Asn Asn Tyr Lys Thr 
                165                 170                 175     


Thr Pro Pro Val Leu Asp Ser Asp Gly Ser Phe Phe Leu Tyr Ser Lys 
            180                 185                 190         


Leu Thr Val Asp Lys Ser Arg Trp Gln Gln Gly Asn Val Phe Ser Cys 
        195                 200                 205             


Ser Val Met His Glu Ala Leu His Asn His Tyr Thr Gln Lys Ser Leu 
    210                 215                 220                 


Ser Leu Ser Pro Gly Lys 
225                 230 


<210>  63
<211>  22
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic linker

<400>  63

Gly Gly Pro Gly Ser Ser Lys Ser Cys Asp Lys Thr His Thr Cys Pro 
1               5                   10                  15      


Pro Cys Pro Ala Pro Glu 
            20          


<210>  64
<211>  22
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic linker

<400>  64

Gly Gly Ser Gly Ser Ser Lys Ser Cys Asp Lys Thr His Thr Cys Pro 
1               5                   10                  15      


Pro Cys Pro Ala Pro Glu 
            20          


<210>  65
<211>  27
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic linker

<400>  65

Gly Gly Pro Gly Ser Ser Ser Ser Ser Ser Ser Lys Ser Cys Asp Lys 
1               5                   10                  15      


Thr His Thr Cys Pro Pro Cys Pro Ala Pro Glu 
            20                  25          


<210>  66
<211>  27
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic linker

<400>  66

Gly Gly Ser Gly Ser Ser Ser Ser Ser Ser Ser Lys Ser Cys Asp Lys 
1               5                   10                  15      


Thr His Thr Cys Pro Pro Cys Pro Ala Pro Glu 
            20                  25          


<210>  67
<211>  29
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic linker

<400>  67

Gly Gly Pro Gly Ser Ser Ser Ser Ser Ser Ser Ser Ser Lys Ser Cys 
1               5                   10                  15      


Asp Lys Thr His Thr Cys Pro Pro Cys Pro Ala Pro Glu 
            20                  25                  


<210>  68
<211>  29
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic linker

<400>  68

Gly Gly Ser Gly Ser Ser Ser Ser Ser Ser Ser Ser Ser Lys Ser Cys 
1               5                   10                  15      


Asp Lys Thr His Thr Cys Pro Pro Cys Pro Ala Pro Glu 
            20                  25                  


<210>  69
<211>  24
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic linker

<400>  69

Gly Gly Pro Gly Ser Ser Gly Ser Gly Ser Ser Asp Lys Thr His Thr 
1               5                   10                  15      


Cys Pro Pro Cys Pro Ala Pro Glu 
            20                  


<210>  70
<211>  23
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic linker

<400>  70

Gly Gly Pro Gly Ser Ser Gly Ser Gly Ser Asp Lys Thr His Thr Cys 
1               5                   10                  15      


Pro Pro Cys Pro Ala Pro Glu 
            20              


<210>  71
<211>  21
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic linker

<400>  71

Gly Gly Pro Ser Ser Ser Gly Ser Asp Lys Thr His Thr Cys Pro Pro 
1               5                   10                  15      


Cys Pro Ala Pro Glu 
            20      


<210>  72
<211>  25
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic linker

<400>  72

Gly Gly Ser Ser Ser Ser Ser Ser Ser Ser Gly Ser Asp Lys Thr His 
1               5                   10                  15      


Thr Cys Pro Pro Cys Pro Ala Pro Glu 
            20                  25  


<210>  73
<211>  246
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic Fc domain

<400>  73

Met Glu Thr Asp Thr Leu Leu Leu Trp Val Leu Leu Leu Trp Val Pro 
1               5                   10                  15      


Ala Gly Asn Gly Asp Lys Thr His Thr Cys Pro Pro Cys Pro Ala Pro 
            20                  25                  30          


Glu Leu Leu Gly Gly Pro Ser Val Phe Leu Phe Pro Pro Lys Pro Lys 
        35                  40                  45              


Asp Thr Leu Met Ile Ser Arg Thr Pro Glu Val Thr Cys Val Val Val 
    50                  55                  60                  


Asp Val Ser His Glu Asp Pro Glu Val Lys Phe Asn Trp Tyr Val Asp 
65                  70                  75                  80  


Gly Val Glu Val His Asn Ala Lys Thr Lys Pro Arg Glu Glu Gln Tyr 
                85                  90                  95      


Asn Ser Thr Tyr Arg Val Val Ser Val Leu Thr Val Leu His Gln Asp 
            100                 105                 110         


Trp Leu Asn Gly Lys Glu Tyr Lys Cys Lys Val Ser Asn Lys Ala Leu 
        115                 120                 125             


Pro Ala Pro Ile Glu Lys Thr Ile Ser Lys Ala Lys Gly Gln Pro Arg 
    130                 135                 140                 


Glu Pro Gln Val Tyr Thr Leu Pro Pro Ser Arg Glu Glu Met Thr Lys 
145                 150                 155                 160 


Asn Gln Val Ser Leu Thr Cys Leu Val Lys Gly Phe Tyr Pro Ser Asp 
                165                 170                 175     


Ile Ala Val Glu Trp Glu Ser Asn Gly Gln Pro Glu Asn Asn Tyr Lys 
            180                 185                 190         


Thr Thr Pro Pro Val Leu Asp Ser Asp Gly Ser Phe Phe Leu Tyr Ser 
        195                 200                 205             


Lys Leu Thr Val Asp Lys Ser Arg Trp Gln Gln Gly Asn Val Phe Ser 
    210                 215                 220                 


Cys Ser Val Met His Glu Ala Leu His Asn His Tyr Thr Gln Lys Ser 
225                 230                 235                 240 


Leu Ser Leu Ser Pro Gly 
                245     


<210>  74
<211>  11
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic linker

<400>  74

Ser Gly Ser Gly Ser Gly Ser Gly Ser Gly Ser 
1               5                   10      


<210>  75
<211>  12
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic linker

<400>  75

Ser Ser Ser Ser Ser Ser Gly Ser Gly Ser Gly Ser 
1               5                   10          


<210>  76
<211>  16
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic linker

<400>  76

Ser Ser Ser Ser Ser Ser Gly Ser Gly Ser Gly Ser Gly Ser Gly Ser 
1               5                   10                  15      


<210>  77
<211>  254
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic 4-1BBL

<400>  77

Met Glu Tyr Ala Ser Asp Ala Ser Leu Asp Pro Glu Ala Pro Trp Pro 
1               5                   10                  15      


Pro Ala Pro Arg Ala Arg Ala Cys Arg Val Leu Pro Trp Ala Leu Val 
            20                  25                  30          


Ala Gly Leu Leu Leu Leu Leu Leu Leu Ala Ala Ala Cys Ala Val Phe 
        35                  40                  45              


Leu Ala Cys Pro Trp Ala Val Ser Gly Ala Arg Ala Ser Pro Gly Ser 
    50                  55                  60                  


Ala Ala Ser Pro Arg Leu Arg Glu Gly Pro Glu Leu Ser Pro Asp Asp 
65                  70                  75                  80  


Pro Ala Gly Leu Leu Asp Leu Arg Gln Gly Met Phe Ala Gln Leu Val 
                85                  90                  95      


Ala Gln Asn Val Leu Leu Ile Asp Gly Pro Leu Ser Trp Tyr Ser Asp 
            100                 105                 110         


Pro Gly Leu Ala Gly Val Ser Leu Thr Gly Gly Leu Ser Tyr Lys Glu 
        115                 120                 125             


Asp Thr Lys Glu Leu Val Val Ala Lys Ala Gly Val Tyr Tyr Val Phe 
    130                 135                 140                 


Phe Gln Leu Glu Leu Arg Arg Val Val Ala Gly Glu Gly Ser Gly Ser 
145                 150                 155                 160 


Val Ser Leu Ala Leu His Leu Gln Pro Leu Arg Ser Ala Ala Gly Ala 
                165                 170                 175     


Ala Ala Leu Ala Leu Thr Val Asp Leu Pro Pro Ala Ser Ser Glu Ala 
            180                 185                 190         


Arg Asn Ser Ala Phe Gly Phe Gln Gly Arg Leu Leu His Leu Ser Ala 
        195                 200                 205             


Gly Gln Arg Leu Gly Val His Leu His Thr Glu Ala Arg Ala Arg His 
    210                 215                 220                 


Ala Trp Gln Leu Thr Gln Gly Ala Thr Val Leu Gly Leu Phe Arg Val 
225                 230                 235                 240 


Thr Pro Glu Ile Pro Ala Gly Leu Pro Ser Pro Arg Ser Glu 
                245                 250                 


<210>  78
<211>  168
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic 4-1BBL soluble domain

<400>  78

Leu Arg Gln Gly Met Phe Ala Gln Leu Val Ala Gln Asn Val Leu Leu 
1               5                   10                  15      


Ile Asp Gly Pro Leu Ser Trp Tyr Ser Asp Pro Gly Leu Ala Gly Val 
            20                  25                  30          


Ser Leu Thr Gly Gly Leu Ser Tyr Lys Glu Asp Thr Lys Glu Leu Val 
        35                  40                  45              


Val Ala Lys Ala Gly Val Tyr Tyr Val Phe Phe Gln Leu Glu Leu Arg 
    50                  55                  60                  


Arg Val Val Ala Gly Glu Gly Ser Gly Ser Val Ser Leu Ala Leu His 
65                  70                  75                  80  


Leu Gln Pro Leu Arg Ser Ala Ala Gly Ala Ala Ala Leu Ala Leu Thr 
                85                  90                  95      


Val Asp Leu Pro Pro Ala Ser Ser Glu Ala Arg Asn Ser Ala Phe Gly 
            100                 105                 110         


Phe Gln Gly Arg Leu Leu His Leu Ser Ala Gly Gln Arg Leu Gly Val 
        115                 120                 125             


His Leu His Thr Glu Ala Arg Ala Arg His Ala Trp Gln Leu Thr Gln 
    130                 135                 140                 


Gly Ala Thr Val Leu Gly Leu Phe Arg Val Thr Pro Glu Ile Pro Ala 
145                 150                 155                 160 


Gly Leu Pro Ser Pro Arg Ser Glu 
                165             


<210>  79
<211>  118
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic variable heavy chain for 4B4-1-1 version 1

<400>  79

Gln Val Gln Leu Gln Gln Pro Gly Ala Glu Leu Val Lys Pro Gly Ala 
1               5                   10                  15      


Ser Val Lys Leu Ser Cys Lys Ala Ser Gly Tyr Thr Phe Ser Ser Tyr 
            20                  25                  30          


Trp Met His Trp Val Lys Gln Arg Pro Gly Gln Val Leu Glu Trp Ile 
        35                  40                  45              


Gly Glu Ile Asn Pro Gly Asn Gly His Thr Asn Tyr Asn Glu Lys Phe 
    50                  55                  60                  


Lys Ser Lys Ala Thr Leu Thr Val Asp Lys Ser Ser Ser Thr Ala Tyr 
65                  70                  75                  80  


Met Gln Leu Ser Ser Leu Thr Ser Glu Asp Ser Ala Val Tyr Tyr Cys 
                85                  90                  95      


Ala Arg Ser Phe Thr Thr Ala Arg Gly Phe Ala Tyr Trp Gly Gln Gly 
            100                 105                 110         


Thr Leu Val Thr Val Ser 
        115             


<210>  80
<211>  107
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic variable light chain for 4B4-1-1 version 1

<400>  80

Asp Ile Val Met Thr Gln Ser Pro Ala Thr Gln Ser Val Thr Pro Gly 
1               5                   10                  15      


Asp Arg Val Ser Leu Ser Cys Arg Ala Ser Gln Thr Ile Ser Asp Tyr 
            20                  25                  30          


Leu His Trp Tyr Gln Gln Lys Ser His Glu Ser Pro Arg Leu Leu Ile 
        35                  40                  45              


Lys Tyr Ala Ser Gln Ser Ile Ser Gly Ile Pro Ser Arg Phe Ser Gly 
    50                  55                  60                  


Ser Gly Ser Gly Ser Asp Phe Thr Leu Ser Ile Asn Ser Val Glu Pro 
65                  70                  75                  80  


Glu Asp Val Gly Val Tyr Tyr Cys Gln Asp Gly His Ser Phe Pro Pro 
                85                  90                  95      


Thr Phe Gly Gly Gly Thr Lys Leu Glu Ile Lys 
            100                 105         


<210>  81
<211>  119
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic variable heavy chain for 4B4-1-1 version 2

<400>  81

Gln Val Gln Leu Gln Gln Pro Gly Ala Glu Leu Val Lys Pro Gly Ala 
1               5                   10                  15      


Ser Val Lys Leu Ser Cys Lys Ala Ser Gly Tyr Thr Phe Ser Ser Tyr 
            20                  25                  30          


Trp Met His Trp Val Lys Gln Arg Pro Gly Gln Val Leu Glu Trp Ile 
        35                  40                  45              


Gly Glu Ile Asn Pro Gly Asn Gly His Thr Asn Tyr Asn Glu Lys Phe 
    50                  55                  60                  


Lys Ser Lys Ala Thr Leu Thr Val Asp Lys Ser Ser Ser Thr Ala Tyr 
65                  70                  75                  80  


Met Gln Leu Ser Ser Leu Thr Ser Glu Asp Ser Ala Val Tyr Tyr Cys 
                85                  90                  95      


Ala Arg Ser Phe Thr Thr Ala Arg Gly Phe Ala Tyr Trp Gly Gln Gly 
            100                 105                 110         


Thr Leu Val Thr Val Ser Ala 
        115                 


<210>  82
<211>  108
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic variable light chain for 4B4-1-1 version 2

<400>  82

Asp Ile Val Met Thr Gln Ser Pro Ala Thr Gln Ser Val Thr Pro Gly 
1               5                   10                  15      


Asp Arg Val Ser Leu Ser Cys Arg Ala Ser Gln Thr Ile Ser Asp Tyr 
            20                  25                  30          


Leu His Trp Tyr Gln Gln Lys Ser His Glu Ser Pro Arg Leu Leu Ile 
        35                  40                  45              


Lys Tyr Ala Ser Gln Ser Ile Ser Gly Ile Pro Ser Arg Phe Ser Gly 
    50                  55                  60                  


Ser Gly Ser Gly Ser Asp Phe Thr Leu Ser Ile Asn Ser Val Glu Pro 
65                  70                  75                  80  


Glu Asp Val Gly Val Tyr Tyr Cys Gln Asp Gly His Ser Phe Pro Pro 
                85                  90                  95      


Thr Phe Gly Gly Gly Thr Lys Leu Glu Ile Lys Arg 
            100                 105             


<210>  83
<211>  120
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic variable heavy chain for H39E3-2

<400>  83

Met Asp Trp Thr Trp Arg Ile Leu Phe Leu Val Ala Ala Ala Thr Gly 
1               5                   10                  15      


Ala His Ser Glu Val Gln Leu Val Glu Ser Gly Gly Gly Leu Val Gln 
            20                  25                  30          


Pro Gly Gly Ser Leu Arg Leu Ser Cys Ala Ala Ser Gly Phe Thr Phe 
        35                  40                  45              


Ser Asp Tyr Trp Met Ser Trp Val Arg Gln Ala Pro Gly Lys Gly Leu 
    50                  55                  60                  


Glu Trp Val Ala Asp Ile Lys Asn Asp Gly Ser Tyr Thr Asn Tyr Ala 
65                  70                  75                  80  


Pro Ser Leu Thr Asn Arg Phe Thr Ile Ser Arg Asp Asn Ala Lys Asn 
                85                  90                  95      


Ser Leu Tyr Leu Gln Met Asn Ser Leu Arg Ala Glu Asp Thr Ala Val 
            100                 105                 110         


Tyr Tyr Cys Ala Arg Glu Leu Thr 
        115                 120 


<210>  84
<211>  109
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic variable light chain for H39E3-2

<400>  84

Met Glu Ala Pro Ala Gln Leu Leu Phe Leu Leu Leu Leu Trp Leu Pro 
1               5                   10                  15      


Asp Thr Thr Gly Asp Ile Val Met Thr Gln Ser Pro Asp Ser Leu Ala 
            20                  25                  30          


Val Ser Leu Gly Glu Arg Ala Thr Ile Asn Cys Lys Ser Ser Gln Ser 
        35                  40                  45              


Leu Leu Ser Ser Gly Asn Gln Lys Asn Tyr Leu Trp Tyr Gln Gln Lys 
    50                  55                  60                  


Pro Gly Gln Pro Pro Lys Leu Leu Ile Tyr Tyr Ala Ser Thr Arg Gln 
65                  70                  75                  80  


Ser Gly Val Pro Asp Arg Phe Ser Gly Ser Gly Ser Gly Thr Asp Phe 
                85                  90                  95      


Thr Leu Thr Ile Ser Ser Leu Gln Ala Glu Asp Val Ala 
            100                 105                 


<210>  85
<211>  277
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic human OX40 (Homo sapiens)

<400>  85

Met Cys Val Gly Ala Arg Arg Leu Gly Arg Gly Pro Cys Ala Ala Leu 
1               5                   10                  15      


Leu Leu Leu Gly Leu Gly Leu Ser Thr Val Thr Gly Leu His Cys Val 
            20                  25                  30          


Gly Asp Thr Tyr Pro Ser Asn Asp Arg Cys Cys His Glu Cys Arg Pro 
        35                  40                  45              


Gly Asn Gly Met Val Ser Arg Cys Ser Arg Ser Gln Asn Thr Val Cys 
    50                  55                  60                  


Arg Pro Cys Gly Pro Gly Phe Tyr Asn Asp Val Val Ser Ser Lys Pro 
65                  70                  75                  80  


Cys Lys Pro Cys Thr Trp Cys Asn Leu Arg Ser Gly Ser Glu Arg Lys 
                85                  90                  95      


Gln Leu Cys Thr Ala Thr Gln Asp Thr Val Cys Arg Cys Arg Ala Gly 
            100                 105                 110         


Thr Gln Pro Leu Asp Ser Tyr Lys Pro Gly Val Asp Cys Ala Pro Cys 
        115                 120                 125             


Pro Pro Gly His Phe Ser Pro Gly Asp Asn Gln Ala Cys Lys Pro Trp 
    130                 135                 140                 


Thr Asn Cys Thr Leu Ala Gly Lys His Thr Leu Gln Pro Ala Ser Asn 
145                 150                 155                 160 


Ser Ser Asp Ala Ile Cys Glu Asp Arg Asp Pro Pro Ala Thr Gln Pro 
                165                 170                 175     


Gln Glu Thr Gln Gly Pro Pro Ala Arg Pro Ile Thr Val Gln Pro Thr 
            180                 185                 190         


Glu Ala Trp Pro Arg Thr Ser Gln Gly Pro Ser Thr Arg Pro Val Glu 
        195                 200                 205             


Val Pro Gly Gly Arg Ala Val Ala Ala Ile Leu Gly Leu Gly Leu Val 
    210                 215                 220                 


Leu Gly Leu Leu Gly Pro Leu Ala Ile Leu Leu Ala Leu Tyr Leu Leu 
225                 230                 235                 240 


Arg Arg Asp Gln Arg Leu Pro Pro Asp Ala His Lys Pro Pro Gly Gly 
                245                 250                 255     


Gly Ser Phe Arg Thr Pro Ile Gln Glu Glu Gln Ala Asp Ala His Ser 
            260                 265                 270         


Thr Leu Ala Lys Ile 
        275         


<210>  86
<211>  272
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic murine OX40 (Mus musculus)

<400>  86

Met Tyr Val Trp Val Gln Gln Pro Thr Ala Leu Leu Leu Leu Gly Leu 
1               5                   10                  15      


Thr Leu Gly Val Thr Ala Arg Arg Leu Asn Cys Val Lys His Thr Tyr 
            20                  25                  30          


Pro Ser Gly His Lys Cys Cys Arg Glu Cys Gln Pro Gly His Gly Met 
        35                  40                  45              


Val Ser Arg Cys Asp His Thr Arg Asp Thr Leu Cys His Pro Cys Glu 
    50                  55                  60                  


Thr Gly Phe Tyr Asn Glu Ala Val Asn Tyr Asp Thr Cys Lys Gln Cys 
65                  70                  75                  80  


Thr Gln Cys Asn His Arg Ser Gly Ser Glu Leu Lys Gln Asn Cys Thr 
                85                  90                  95      


Pro Thr Gln Asp Thr Val Cys Arg Cys Arg Pro Gly Thr Gln Pro Arg 
            100                 105                 110         


Gln Asp Ser Gly Tyr Lys Leu Gly Val Asp Cys Val Pro Cys Pro Pro 
        115                 120                 125             


Gly His Phe Ser Pro Gly Asn Asn Gln Ala Cys Lys Pro Trp Thr Asn 
    130                 135                 140                 


Cys Thr Leu Ser Gly Lys Gln Thr Arg His Pro Ala Ser Asp Ser Leu 
145                 150                 155                 160 


Asp Ala Val Cys Glu Asp Arg Ser Leu Leu Ala Thr Leu Leu Trp Glu 
                165                 170                 175     


Thr Gln Arg Pro Thr Phe Arg Pro Thr Thr Val Gln Ser Thr Thr Val 
            180                 185                 190         


Trp Pro Arg Thr Ser Glu Leu Pro Ser Pro Pro Thr Leu Val Thr Pro 
        195                 200                 205             


Glu Gly Pro Ala Phe Ala Val Leu Leu Gly Leu Gly Leu Gly Leu Leu 
    210                 215                 220                 


Ala Pro Leu Thr Val Leu Leu Ala Leu Tyr Leu Leu Arg Lys Ala Trp 
225                 230                 235                 240 


Arg Leu Pro Asn Thr Pro Lys Pro Cys Trp Gly Asn Ser Phe Arg Thr 
                245                 250                 255     


Pro Ile Gln Glu Glu His Thr Asp Ala His Phe Thr Leu Ala Lys Ile 
            260                 265                 270         


<210>  87
<211>  451
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic heavy chain for tavolixizumab

<400>  87

Gln Val Gln Leu Gln Glu Ser Gly Pro Gly Leu Val Lys Pro Ser Gln 
1               5                   10                  15      


Thr Leu Ser Leu Thr Cys Ala Val Tyr Gly Gly Ser Phe Ser Ser Gly 
            20                  25                  30          


Tyr Trp Asn Trp Ile Arg Lys His Pro Gly Lys Gly Leu Glu Tyr Ile 
        35                  40                  45              


Gly Tyr Ile Ser Tyr Asn Gly Ile Thr Tyr His Asn Pro Ser Leu Lys 
    50                  55                  60                  


Ser Arg Ile Thr Ile Asn Arg Asp Thr Ser Lys Asn Gln Tyr Ser Leu 
65                  70                  75                  80  


Gln Leu Asn Ser Val Thr Pro Glu Asp Thr Ala Val Tyr Tyr Cys Ala 
                85                  90                  95      


Arg Tyr Lys Tyr Asp Tyr Asp Gly Gly His Ala Met Asp Tyr Trp Gly 
            100                 105                 110         


Gln Gly Thr Leu Val Thr Val Ser Ser Ala Ser Thr Lys Gly Pro Ser 
        115                 120                 125             


Val Phe Pro Leu Ala Pro Ser Ser Lys Ser Thr Ser Gly Gly Thr Ala 
    130                 135                 140                 


Ala Leu Gly Cys Leu Val Lys Asp Tyr Phe Pro Glu Pro Val Thr Val 
145                 150                 155                 160 


Ser Trp Asn Ser Gly Ala Leu Thr Ser Gly Val His Thr Phe Pro Ala 
                165                 170                 175     


Val Leu Gln Ser Ser Gly Leu Tyr Ser Leu Ser Ser Val Val Thr Val 
            180                 185                 190         


Pro Ser Ser Ser Leu Gly Thr Gln Thr Tyr Ile Cys Asn Val Asn His 
        195                 200                 205             


Lys Pro Ser Asn Thr Lys Val Asp Lys Arg Val Glu Pro Lys Ser Cys 
    210                 215                 220                 


Asp Lys Thr His Thr Cys Pro Pro Cys Pro Ala Pro Glu Leu Leu Gly 
225                 230                 235                 240 


Gly Pro Ser Val Phe Leu Phe Pro Pro Lys Pro Lys Asp Thr Leu Met 
                245                 250                 255     


Ile Ser Arg Thr Pro Glu Val Thr Cys Val Val Val Asp Val Ser His 
            260                 265                 270         


Glu Asp Pro Glu Val Lys Phe Asn Trp Tyr Val Asp Gly Val Glu Val 
        275                 280                 285             


His Asn Ala Lys Thr Lys Pro Arg Glu Glu Gln Tyr Asn Ser Thr Tyr 
    290                 295                 300                 


Arg Val Val Ser Val Leu Thr Val Leu His Gln Asp Trp Leu Asn Gly 
305                 310                 315                 320 


Lys Glu Tyr Lys Cys Lys Val Ser Asn Lys Ala Leu Pro Ala Pro Ile 
                325                 330                 335     


Glu Lys Thr Ile Ser Lys Ala Lys Gly Gln Pro Arg Glu Pro Gln Val 
            340                 345                 350         


Tyr Thr Leu Pro Pro Ser Arg Glu Glu Met Thr Lys Asn Gln Val Ser 
        355                 360                 365             


Leu Thr Cys Leu Val Lys Gly Phe Tyr Pro Ser Asp Ile Ala Val Glu 
    370                 375                 380                 


Trp Glu Ser Asn Gly Gln Pro Glu Asn Asn Tyr Lys Thr Thr Pro Pro 
385                 390                 395                 400 


Val Leu Asp Ser Asp Gly Ser Phe Phe Leu Tyr Ser Lys Leu Thr Val 
                405                 410                 415     


Asp Lys Ser Arg Trp Gln Gln Gly Asn Val Phe Ser Cys Ser Val Met 
            420                 425                 430         


His Glu Ala Leu His Asn His Tyr Thr Gln Lys Ser Leu Ser Leu Ser 
        435                 440                 445             


Pro Gly Lys 
    450     


<210>  88
<211>  214
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic light chain for tavolixizumab

<400>  88

Asp Ile Gln Met Thr Gln Ser Pro Ser Ser Leu Ser Ala Ser Val Gly 
1               5                   10                  15      


Asp Arg Val Thr Ile Thr Cys Arg Ala Ser Gln Asp Ile Ser Asn Tyr 
            20                  25                  30          


Leu Asn Trp Tyr Gln Gln Lys Pro Gly Lys Ala Pro Lys Leu Leu Ile 
        35                  40                  45              


Tyr Tyr Thr Ser Lys Leu His Ser Gly Val Pro Ser Arg Phe Ser Gly 
    50                  55                  60                  


Ser Gly Ser Gly Thr Asp Tyr Thr Leu Thr Ile Ser Ser Leu Gln Pro 
65                  70                  75                  80  


Glu Asp Phe Ala Thr Tyr Tyr Cys Gln Gln Gly Ser Ala Leu Pro Trp 
                85                  90                  95      


Thr Phe Gly Gln Gly Thr Lys Val Glu Ile Lys Arg Thr Val Ala Ala 
            100                 105                 110         


Pro Ser Val Phe Ile Phe Pro Pro Ser Asp Glu Gln Leu Lys Ser Gly 
        115                 120                 125             


Thr Ala Ser Val Val Cys Leu Leu Asn Asn Phe Tyr Pro Arg Glu Ala 
    130                 135                 140                 


Lys Val Gln Trp Lys Val Asp Asn Ala Leu Gln Ser Gly Asn Ser Gln 
145                 150                 155                 160 


Glu Ser Val Thr Glu Gln Asp Ser Lys Asp Ser Thr Tyr Ser Leu Ser 
                165                 170                 175     


Ser Thr Leu Thr Leu Ser Lys Ala Asp Tyr Glu Lys His Lys Val Tyr 
            180                 185                 190         


Ala Cys Glu Val Thr His Gln Gly Leu Ser Ser Pro Val Thr Lys Ser 
        195                 200                 205             


Phe Asn Arg Gly Glu Cys 
    210                 


<210>  89
<211>  118
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic heavy chain variable region for tavolixizumab

<400>  89

Gln Val Gln Leu Gln Glu Ser Gly Pro Gly Leu Val Lys Pro Ser Gln 
1               5                   10                  15      


Thr Leu Ser Leu Thr Cys Ala Val Tyr Gly Gly Ser Phe Ser Ser Gly 
            20                  25                  30          


Tyr Trp Asn Trp Ile Arg Lys His Pro Gly Lys Gly Leu Glu Tyr Ile 
        35                  40                  45              


Gly Tyr Ile Ser Tyr Asn Gly Ile Thr Tyr His Asn Pro Ser Leu Lys 
    50                  55                  60                  


Ser Arg Ile Thr Ile Asn Arg Asp Thr Ser Lys Asn Gln Tyr Ser Leu 
65                  70                  75                  80  


Gln Leu Asn Ser Val Thr Pro Glu Asp Thr Ala Val Tyr Tyr Cys Ala 
                85                  90                  95      


Arg Tyr Lys Tyr Asp Tyr Asp Gly Gly His Ala Met Asp Tyr Trp Gly 
            100                 105                 110         


Gln Gly Thr Leu Val Thr 
        115             


<210>  90
<211>  108
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic light chain variable region for tavolixizumab

<400>  90

Asp Ile Gln Met Thr Gln Ser Pro Ser Ser Leu Ser Ala Ser Val Gly 
1               5                   10                  15      


Asp Arg Val Thr Ile Thr Cys Arg Ala Ser Gln Asp Ile Ser Asn Tyr 
            20                  25                  30          


Leu Asn Trp Tyr Gln Gln Lys Pro Gly Lys Ala Pro Lys Leu Leu Ile 
        35                  40                  45              


Tyr Tyr Thr Ser Lys Leu His Ser Gly Val Pro Ser Arg Phe Ser Gly 
    50                  55                  60                  


Ser Gly Ser Gly Thr Asp Tyr Thr Leu Thr Ile Ser Ser Leu Gln Pro 
65                  70                  75                  80  


Glu Asp Phe Ala Thr Tyr Tyr Cys Gln Gln Gly Ser Ala Leu Pro Trp 
                85                  90                  95      


Thr Phe Gly Gln Gly Thr Lys Val Glu Ile Lys Arg 
            100                 105             


<210>  91
<211>  9
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic heavy chain CDR1 for tavolixizumab

<400>  91

Gly Ser Phe Ser Ser Gly Tyr Trp Asn 
1               5                   


<210>  92
<211>  13
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic heavy chain CDR2 for tavolixizumab

<400>  92

Tyr Ile Gly Tyr Ile Ser Tyr Asn Gly Ile Thr Tyr His 
1               5                   10              


<210>  93
<211>  14
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic heavy chain CDR3 for tavolixizumab

<400>  93

Arg Tyr Lys Tyr Asp Tyr Asp Gly Gly His Ala Met Asp Tyr 
1               5                   10                  


<210>  94
<211>  8
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic light chain CDR1 for tavolixizumab

<400>  94

Gln Asp Ile Ser Asn Tyr Leu Asn 
1               5               


<210>  95
<211>  11
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic light chain CDR2 for tavolixizumab

<400>  95

Leu Leu Ile Tyr Tyr Thr Ser Lys Leu His Ser 
1               5                   10      


<210>  96
<211>  8
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic light chain CDR3 for tavolixizumab

<400>  96

Gln Gln Gly Ser Ala Leu Pro Trp 
1               5               


<210>  97
<211>  444
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic heavy chain for 11D4

<400>  97

Glu Val Gln Leu Val Glu Ser Gly Gly Gly Leu Val Gln Pro Gly Gly 
1               5                   10                  15      


Ser Leu Arg Leu Ser Cys Ala Ala Ser Gly Phe Thr Phe Ser Ser Tyr 
            20                  25                  30          


Ser Met Asn Trp Val Arg Gln Ala Pro Gly Lys Gly Leu Glu Trp Val 
        35                  40                  45              


Ser Tyr Ile Ser Ser Ser Ser Ser Thr Ile Asp Tyr Ala Asp Ser Val 
    50                  55                  60                  


Lys Gly Arg Phe Thr Ile Ser Arg Asp Asn Ala Lys Asn Ser Leu Tyr 
65                  70                  75                  80  


Leu Gln Met Asn Ser Leu Arg Asp Glu Asp Thr Ala Val Tyr Tyr Cys 
                85                  90                  95      


Ala Arg Glu Ser Gly Trp Tyr Leu Phe Asp Tyr Trp Gly Gln Gly Thr 
            100                 105                 110         


Leu Val Thr Val Ser Ser Ala Ser Thr Lys Gly Pro Ser Val Phe Pro 
        115                 120                 125             


Leu Ala Pro Cys Ser Arg Ser Thr Ser Glu Ser Thr Ala Ala Leu Gly 
    130                 135                 140                 


Cys Leu Val Lys Asp Tyr Phe Pro Glu Pro Val Thr Val Ser Trp Asn 
145                 150                 155                 160 


Ser Gly Ala Leu Thr Ser Gly Val His Thr Phe Pro Ala Val Leu Gln 
                165                 170                 175     


Ser Ser Gly Leu Tyr Ser Leu Ser Ser Val Val Thr Val Pro Ser Ser 
            180                 185                 190         


Asn Phe Gly Thr Gln Thr Tyr Thr Cys Asn Val Asp His Lys Pro Ser 
        195                 200                 205             


Asn Thr Lys Val Asp Lys Thr Val Glu Arg Lys Cys Cys Val Glu Cys 
    210                 215                 220                 


Pro Pro Cys Pro Ala Pro Pro Val Ala Gly Pro Ser Val Phe Leu Phe 
225                 230                 235                 240 


Pro Pro Lys Pro Lys Asp Thr Leu Met Ile Ser Arg Thr Pro Glu Val 
                245                 250                 255     


Thr Cys Val Val Val Asp Val Ser His Glu Asp Pro Glu Val Gln Phe 
            260                 265                 270         


Asn Trp Tyr Val Asp Gly Val Glu Val His Asn Ala Lys Thr Lys Pro 
        275                 280                 285             


Arg Glu Glu Gln Phe Asn Ser Thr Phe Arg Val Val Ser Val Leu Thr 
    290                 295                 300                 


Val Val His Gln Asp Trp Leu Asn Gly Lys Glu Tyr Lys Cys Lys Val 
305                 310                 315                 320 


Ser Asn Lys Gly Leu Pro Ala Pro Ile Glu Lys Thr Ile Ser Lys Thr 
                325                 330                 335     


Lys Gly Gln Pro Arg Glu Pro Gln Val Tyr Thr Leu Pro Pro Ser Arg 
            340                 345                 350         


Glu Glu Met Thr Lys Asn Gln Val Ser Leu Thr Cys Leu Val Lys Gly 
        355                 360                 365             


Phe Tyr Pro Ser Asp Ile Ala Val Glu Trp Glu Ser Asn Gly Gln Pro 
    370                 375                 380                 


Glu Asn Asn Tyr Lys Thr Thr Pro Pro Met Leu Asp Ser Asp Gly Ser 
385                 390                 395                 400 


Phe Phe Leu Tyr Ser Lys Leu Thr Val Asp Lys Ser Arg Trp Gln Gln 
                405                 410                 415     


Gly Asn Val Phe Ser Cys Ser Val Met His Glu Ala Leu His Asn His 
            420                 425                 430         


Tyr Thr Gln Lys Ser Leu Ser Leu Ser Pro Gly Lys 
        435                 440                 


<210>  98
<211>  214
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic light chain for 11D4

<400>  98

Asp Ile Gln Met Thr Gln Ser Pro Ser Ser Leu Ser Ala Ser Val Gly 
1               5                   10                  15      


Asp Arg Val Thr Ile Thr Cys Arg Ala Ser Gln Gly Ile Ser Ser Trp 
            20                  25                  30          


Leu Ala Trp Tyr Gln Gln Lys Pro Glu Lys Ala Pro Lys Ser Leu Ile 
        35                  40                  45              


Tyr Ala Ala Ser Ser Leu Gln Ser Gly Val Pro Ser Arg Phe Ser Gly 
    50                  55                  60                  


Ser Gly Ser Gly Thr Asp Phe Thr Leu Thr Ile Ser Ser Leu Gln Pro 
65                  70                  75                  80  


Glu Asp Phe Ala Thr Tyr Tyr Cys Gln Gln Tyr Asn Ser Tyr Pro Pro 
                85                  90                  95      


Thr Phe Gly Gly Gly Thr Lys Val Glu Ile Lys Arg Thr Val Ala Ala 
            100                 105                 110         


Pro Ser Val Phe Ile Phe Pro Pro Ser Asp Glu Gln Leu Lys Ser Gly 
        115                 120                 125             


Thr Ala Ser Val Val Cys Leu Leu Asn Asn Phe Tyr Pro Arg Glu Ala 
    130                 135                 140                 


Lys Val Gln Trp Lys Val Asp Asn Ala Leu Gln Ser Gly Asn Ser Gln 
145                 150                 155                 160 


Glu Ser Val Thr Glu Gln Asp Ser Lys Asp Ser Thr Tyr Ser Leu Ser 
                165                 170                 175     


Ser Thr Leu Thr Leu Ser Lys Ala Asp Tyr Glu Lys His Lys Val Tyr 
            180                 185                 190         


Ala Cys Glu Val Thr His Gln Gly Leu Ser Ser Pro Val Thr Lys Ser 
        195                 200                 205             


Phe Asn Arg Gly Glu Cys 
    210                 


<210>  99
<211>  118
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic heavy chain variable region for 11D4

<400>  99

Glu Val Gln Leu Val Glu Ser Gly Gly Gly Leu Val Gln Pro Gly Gly 
1               5                   10                  15      


Ser Leu Arg Leu Ser Cys Ala Ala Ser Gly Phe Thr Phe Ser Ser Tyr 
            20                  25                  30          


Ser Met Asn Trp Val Arg Gln Ala Pro Gly Lys Gly Leu Glu Trp Val 
        35                  40                  45              


Ser Tyr Ile Ser Ser Ser Ser Ser Thr Ile Asp Tyr Ala Asp Ser Val 
    50                  55                  60                  


Lys Gly Arg Phe Thr Ile Ser Arg Asp Asn Ala Lys Asn Ser Leu Tyr 
65                  70                  75                  80  


Leu Gln Met Asn Ser Leu Arg Asp Glu Asp Thr Ala Val Tyr Tyr Cys 
                85                  90                  95      


Ala Arg Glu Ser Gly Trp Tyr Leu Phe Asp Tyr Trp Gly Gln Gly Thr 
            100                 105                 110         


Leu Val Thr Val Ser Ser 
        115             


<210>  100
<211>  107
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic light chain variable region for 11D4

<400>  100

Asp Ile Gln Met Thr Gln Ser Pro Ser Ser Leu Ser Ala Ser Val Gly 
1               5                   10                  15      


Asp Arg Val Thr Ile Thr Cys Arg Ala Ser Gln Gly Ile Ser Ser Trp 
            20                  25                  30          


Leu Ala Trp Tyr Gln Gln Lys Pro Glu Lys Ala Pro Lys Ser Leu Ile 
        35                  40                  45              


Tyr Ala Ala Ser Ser Leu Gln Ser Gly Val Pro Ser Arg Phe Ser Gly 
    50                  55                  60                  


Ser Gly Ser Gly Thr Asp Phe Thr Leu Thr Ile Ser Ser Leu Gln Pro 
65                  70                  75                  80  


Glu Asp Phe Ala Thr Tyr Tyr Cys Gln Gln Tyr Asn Ser Tyr Pro Pro 
                85                  90                  95      


Thr Phe Gly Gly Gly Thr Lys Val Glu Ile Lys 
            100                 105         


<210>  101
<211>  5
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic heavy chain CDR1 for 11D4

<400>  101

Ser Tyr Ser Met Asn 
1               5   


<210>  102
<211>  17
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic heavy chain CDR2 for 11D4

<400>  102

Tyr Ile Ser Ser Ser Ser Ser Thr Ile Asp Tyr Ala Asp Ser Val Lys 
1               5                   10                  15      


Gly 
    


<210>  103
<211>  9
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic heavy chain CDR3 for 11D4

<400>  103

Glu Ser Gly Trp Tyr Leu Phe Asp Tyr 
1               5                   


<210>  104
<211>  11
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic light chain CDR1 for 11D4

<400>  104

Arg Ala Ser Gln Gly Ile Ser Ser Trp Leu Ala 
1               5                   10      


<210>  105
<211>  7
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic light chain CDR2 for 11D4

<400>  105

Ala Ala Ser Ser Leu Gln Ser 
1               5           


<210>  106
<211>  9
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic light chain CDR3 for 11D4

<400>  106

Gln Gln Tyr Asn Ser Tyr Pro Pro Thr 
1               5                   


<210>  107
<211>  450
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic heavy chain for 18D8

<400>  107

Glu Val Gln Leu Val Glu Ser Gly Gly Gly Leu Val Gln Pro Gly Arg 
1               5                   10                  15      


Ser Leu Arg Leu Ser Cys Ala Ala Ser Gly Phe Thr Phe Asp Asp Tyr 
            20                  25                  30          


Ala Met His Trp Val Arg Gln Ala Pro Gly Lys Gly Leu Glu Trp Val 
        35                  40                  45              


Ser Gly Ile Ser Trp Asn Ser Gly Ser Ile Gly Tyr Ala Asp Ser Val 
    50                  55                  60                  


Lys Gly Arg Phe Thr Ile Ser Arg Asp Asn Ala Lys Asn Ser Leu Tyr 
65                  70                  75                  80  


Leu Gln Met Asn Ser Leu Arg Ala Glu Asp Thr Ala Leu Tyr Tyr Cys 
                85                  90                  95      


Ala Lys Asp Gln Ser Thr Ala Asp Tyr Tyr Phe Tyr Tyr Gly Met Asp 
            100                 105                 110         


Val Trp Gly Gln Gly Thr Thr Val Thr Val Ser Ser Ala Ser Thr Lys 
        115                 120                 125             


Gly Pro Ser Val Phe Pro Leu Ala Pro Cys Ser Arg Ser Thr Ser Glu 
    130                 135                 140                 


Ser Thr Ala Ala Leu Gly Cys Leu Val Lys Asp Tyr Phe Pro Glu Pro 
145                 150                 155                 160 


Val Thr Val Ser Trp Asn Ser Gly Ala Leu Thr Ser Gly Val His Thr 
                165                 170                 175     


Phe Pro Ala Val Leu Gln Ser Ser Gly Leu Tyr Ser Leu Ser Ser Val 
            180                 185                 190         


Val Thr Val Pro Ser Ser Asn Phe Gly Thr Gln Thr Tyr Thr Cys Asn 
        195                 200                 205             


Val Asp His Lys Pro Ser Asn Thr Lys Val Asp Lys Thr Val Glu Arg 
    210                 215                 220                 


Lys Cys Cys Val Glu Cys Pro Pro Cys Pro Ala Pro Pro Val Ala Gly 
225                 230                 235                 240 


Pro Ser Val Phe Leu Phe Pro Pro Lys Pro Lys Asp Thr Leu Met Ile 
                245                 250                 255     


Ser Arg Thr Pro Glu Val Thr Cys Val Val Val Asp Val Ser His Glu 
            260                 265                 270         


Asp Pro Glu Val Gln Phe Asn Trp Tyr Val Asp Gly Val Glu Val His 
        275                 280                 285             


Asn Ala Lys Thr Lys Pro Arg Glu Glu Gln Phe Asn Ser Thr Phe Arg 
    290                 295                 300                 


Val Val Ser Val Leu Thr Val Val His Gln Asp Trp Leu Asn Gly Lys 
305                 310                 315                 320 


Glu Tyr Lys Cys Lys Val Ser Asn Lys Gly Leu Pro Ala Pro Ile Glu 
                325                 330                 335     


Lys Thr Ile Ser Lys Thr Lys Gly Gln Pro Arg Glu Pro Gln Val Tyr 
            340                 345                 350         


Thr Leu Pro Pro Ser Arg Glu Glu Met Thr Lys Asn Gln Val Ser Leu 
        355                 360                 365             


Thr Cys Leu Val Lys Gly Phe Tyr Pro Ser Asp Ile Ala Val Glu Trp 
    370                 375                 380                 


Glu Ser Asn Gly Gln Pro Glu Asn Asn Tyr Lys Thr Thr Pro Pro Met 
385                 390                 395                 400 


Leu Asp Ser Asp Gly Ser Phe Phe Leu Tyr Ser Lys Leu Thr Val Asp 
                405                 410                 415     


Lys Ser Arg Trp Gln Gln Gly Asn Val Phe Ser Cys Ser Val Met His 
            420                 425                 430         


Glu Ala Leu His Asn His Tyr Thr Gln Lys Ser Leu Ser Leu Ser Pro 
        435                 440                 445             


Gly Lys 
    450 


<210>  108
<211>  213
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic light chain for 18D8

<400>  108

Glu Ile Val Val Thr Gln Ser Pro Ala Thr Leu Ser Leu Ser Pro Gly 
1               5                   10                  15      


Glu Arg Ala Thr Leu Ser Cys Arg Ala Ser Gln Ser Val Ser Ser Tyr 
            20                  25                  30          


Leu Ala Trp Tyr Gln Gln Lys Pro Gly Gln Ala Pro Arg Leu Leu Ile 
        35                  40                  45              


Tyr Asp Ala Ser Asn Arg Ala Thr Gly Ile Pro Ala Arg Phe Ser Gly 
    50                  55                  60                  


Ser Gly Ser Gly Thr Asp Phe Thr Leu Thr Ile Ser Ser Leu Glu Pro 
65                  70                  75                  80  


Glu Asp Phe Ala Val Tyr Tyr Cys Gln Gln Arg Ser Asn Trp Pro Thr 
                85                  90                  95      


Phe Gly Gln Gly Thr Lys Val Glu Ile Lys Arg Thr Val Ala Ala Pro 
            100                 105                 110         


Ser Val Phe Ile Phe Pro Pro Ser Asp Glu Gln Leu Lys Ser Gly Thr 
        115                 120                 125             


Ala Ser Val Val Cys Leu Leu Asn Asn Phe Tyr Pro Arg Glu Ala Lys 
    130                 135                 140                 


Val Gln Trp Lys Val Asp Asn Ala Leu Gln Ser Gly Asn Ser Gln Glu 
145                 150                 155                 160 


Ser Val Thr Glu Gln Asp Ser Lys Asp Ser Thr Tyr Ser Leu Ser Ser 
                165                 170                 175     


Thr Leu Thr Leu Ser Lys Ala Asp Tyr Glu Lys His Lys Val Tyr Ala 
            180                 185                 190         


Cys Glu Val Thr His Gln Gly Leu Ser Ser Pro Val Thr Lys Ser Phe 
        195                 200                 205             


Asn Arg Gly Glu Cys 
    210             


<210>  109
<211>  124
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic heavy chain variable region for 18D8

<400>  109

Glu Val Gln Leu Val Glu Ser Gly Gly Gly Leu Val Gln Pro Gly Arg 
1               5                   10                  15      


Ser Leu Arg Leu Ser Cys Ala Ala Ser Gly Phe Thr Phe Asp Asp Tyr 
            20                  25                  30          


Ala Met His Trp Val Arg Gln Ala Pro Gly Lys Gly Leu Glu Trp Val 
        35                  40                  45              


Ser Gly Ile Ser Trp Asn Ser Gly Ser Ile Gly Tyr Ala Asp Ser Val 
    50                  55                  60                  


Lys Gly Arg Phe Thr Ile Ser Arg Asp Asn Ala Lys Asn Ser Leu Tyr 
65                  70                  75                  80  


Leu Gln Met Asn Ser Leu Arg Ala Glu Asp Thr Ala Leu Tyr Tyr Cys 
                85                  90                  95      


Ala Lys Asp Gln Ser Thr Ala Asp Tyr Tyr Phe Tyr Tyr Gly Met Asp 
            100                 105                 110         


Val Trp Gly Gln Gly Thr Thr Val Thr Val Ser Ser 
        115                 120                 


<210>  110
<211>  106
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic light chain variable region for 18D8

<400>  110

Glu Ile Val Val Thr Gln Ser Pro Ala Thr Leu Ser Leu Ser Pro Gly 
1               5                   10                  15      


Glu Arg Ala Thr Leu Ser Cys Arg Ala Ser Gln Ser Val Ser Ser Tyr 
            20                  25                  30          


Leu Ala Trp Tyr Gln Gln Lys Pro Gly Gln Ala Pro Arg Leu Leu Ile 
        35                  40                  45              


Tyr Asp Ala Ser Asn Arg Ala Thr Gly Ile Pro Ala Arg Phe Ser Gly 
    50                  55                  60                  


Ser Gly Ser Gly Thr Asp Phe Thr Leu Thr Ile Ser Ser Leu Glu Pro 
65                  70                  75                  80  


Glu Asp Phe Ala Val Tyr Tyr Cys Gln Gln Arg Ser Asn Trp Pro Thr 
                85                  90                  95      


Phe Gly Gln Gly Thr Lys Val Glu Ile Lys 
            100                 105     


<210>  111
<211>  5
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic heavy chain CDR1 for 18D8

<400>  111

Asp Tyr Ala Met His 
1               5   


<210>  112
<211>  17
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic heavy chain CDR2 for 18D8

<400>  112

Gly Ile Ser Trp Asn Ser Gly Ser Ile Gly Tyr Ala Asp Ser Val Lys 
1               5                   10                  15      


Gly 
    


<210>  113
<211>  15
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic heavy chain CDR3 for 18D8

<400>  113

Asp Gln Ser Thr Ala Asp Tyr Tyr Phe Tyr Tyr Gly Met Asp Val 
1               5                   10                  15  


<210>  114
<211>  11
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic light chain CDR1 for 18D8

<400>  114

Arg Ala Ser Gln Ser Val Ser Ser Tyr Leu Ala 
1               5                   10      


<210>  115
<211>  7
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic light chain CDR2 for 18D8

<400>  115

Asp Ala Ser Asn Arg Ala Thr 
1               5           


<210>  116
<211>  8
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic light chain CDR3 for 18D8

<400>  116

Gln Gln Arg Ser Asn Trp Pro Thr 
1               5               


<210>  117
<211>  120
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic heavy chain variable region for Hu119-122

<400>  117

Glu Val Gln Leu Val Glu Ser Gly Gly Gly Leu Val Gln Pro Gly Gly 
1               5                   10                  15      


Ser Leu Arg Leu Ser Cys Ala Ala Ser Glu Tyr Glu Phe Pro Ser His 
            20                  25                  30          


Asp Met Ser Trp Val Arg Gln Ala Pro Gly Lys Gly Leu Glu Leu Val 
        35                  40                  45              


Ala Ala Ile Asn Ser Asp Gly Gly Ser Thr Tyr Tyr Pro Asp Thr Met 
    50                  55                  60                  


Glu Arg Arg Phe Thr Ile Ser Arg Asp Asn Ala Lys Asn Ser Leu Tyr 
65                  70                  75                  80  


Leu Gln Met Asn Ser Leu Arg Ala Glu Asp Thr Ala Val Tyr Tyr Cys 
                85                  90                  95      


Ala Arg His Tyr Asp Asp Tyr Tyr Ala Trp Phe Ala Tyr Trp Gly Gln 
            100                 105                 110         


Gly Thr Met Val Thr Val Ser Ser 
        115                 120 


<210>  118
<211>  111
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic light chain variable region for Hu119-122

<400>  118

Glu Ile Val Leu Thr Gln Ser Pro Ala Thr Leu Ser Leu Ser Pro Gly 
1               5                   10                  15      


Glu Arg Ala Thr Leu Ser Cys Arg Ala Ser Lys Ser Val Ser Thr Ser 
            20                  25                  30          


Gly Tyr Ser Tyr Met His Trp Tyr Gln Gln Lys Pro Gly Gln Ala Pro 
        35                  40                  45              


Arg Leu Leu Ile Tyr Leu Ala Ser Asn Leu Glu Ser Gly Val Pro Ala 
    50                  55                  60                  


Arg Phe Ser Gly Ser Gly Ser Gly Thr Asp Phe Thr Leu Thr Ile Ser 
65                  70                  75                  80  


Ser Leu Glu Pro Glu Asp Phe Ala Val Tyr Tyr Cys Gln His Ser Arg 
                85                  90                  95      


Glu Leu Pro Leu Thr Phe Gly Gly Gly Thr Lys Val Glu Ile Lys 
            100                 105                 110     


<210>  119
<211>  5
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic heavy chain CDRl for Hu119-122

<400>  119

Ser His Asp Met Ser 
1               5   


<210>  120
<211>  17
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic heavy chain CDR2 for Hu119-122

<400>  120

Ala Ile Asn Ser Asp Gly Gly Ser Thr Tyr Tyr Pro Asp Thr Met Glu 
1               5                   10                  15      


Arg 
    


<210>  121
<211>  11
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic heavy chain CDR3 for Hu119-122

<400>  121

His Tyr Asp Asp Tyr Tyr Ala Trp Phe Ala Tyr 
1               5                   10      


<210>  122
<211>  15
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic light chain CDR1 for Hu119-122

<400>  122

Arg Ala Ser Lys Ser Val Ser Thr Ser Gly Tyr Ser Tyr Met His 
1               5                   10                  15  


<210>  123
<211>  7
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic light chain CDR2 for Hu119-122

<400>  123

Leu Ala Ser Asn Leu Glu Ser 
1               5           


<210>  124
<211>  9
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic light chain CDR3 for Hu119-122

<400>  124

Gln His Ser Arg Glu Leu Pro Leu Thr 
1               5                   


<210>  125
<211>  122
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic heavy chain variable region for Hu106-222

<400>  125

Gln Val Gln Leu Val Gln Ser Gly Ser Glu Leu Lys Lys Pro Gly Ala 
1               5                   10                  15      


Ser Val Lys Val Ser Cys Lys Ala Ser Gly Tyr Thr Phe Thr Asp Tyr 
            20                  25                  30          


Ser Met His Trp Val Arg Gln Ala Pro Gly Gln Gly Leu Lys Trp Met 
        35                  40                  45              


Gly Trp Ile Asn Thr Glu Thr Gly Glu Pro Thr Tyr Ala Asp Asp Phe 
    50                  55                  60                  


Lys Gly Arg Phe Val Phe Ser Leu Asp Thr Ser Val Ser Thr Ala Tyr 
65                  70                  75                  80  


Leu Gln Ile Ser Ser Leu Lys Ala Glu Asp Thr Ala Val Tyr Tyr Cys 
                85                  90                  95      


Ala Asn Pro Tyr Tyr Asp Tyr Val Ser Tyr Tyr Ala Met Asp Tyr Trp 
            100                 105                 110         


Gly Gln Gly Thr Thr Val Thr Val Ser Ser 
        115                 120         


<210>  126
<211>  107
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic light chain variable region for Hu106-222

<400>  126

Asp Ile Gln Met Thr Gln Ser Pro Ser Ser Leu Ser Ala Ser Val Gly 
1               5                   10                  15      


Asp Arg Val Thr Ile Thr Cys Lys Ala Ser Gln Asp Val Ser Thr Ala 
            20                  25                  30          


Val Ala Trp Tyr Gln Gln Lys Pro Gly Lys Ala Pro Lys Leu Leu Ile 
        35                  40                  45              


Tyr Ser Ala Ser Tyr Leu Tyr Thr Gly Val Pro Ser Arg Phe Ser Gly 
    50                  55                  60                  


Ser Gly Ser Gly Thr Asp Phe Thr Phe Thr Ile Ser Ser Leu Gln Pro 
65                  70                  75                  80  


Glu Asp Ile Ala Thr Tyr Tyr Cys Gln Gln His Tyr Ser Thr Pro Arg 
                85                  90                  95      


Thr Phe Gly Gln Gly Thr Lys Leu Glu Ile Lys 
            100                 105         


<210>  127
<211>  5
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic heavy chain CDR1 for Hu106-222

<400>  127

Asp Tyr Ser Met His 
1               5   


<210>  128
<211>  17
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic heavy chain CDR2 for Hu106-222

<400>  128

Trp Ile Asn Thr Glu Thr Gly Glu Pro Thr Tyr Ala Asp Asp Phe Lys 
1               5                   10                  15      


Gly 
    


<210>  129
<211>  13
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic heavy chain CDR3 for Hu106-222

<400>  129

Pro Tyr Tyr Asp Tyr Val Ser Tyr Tyr Ala Met Asp Tyr 
1               5                   10              


<210>  130
<211>  11
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic light chain CDR1 for Hu106-222

<400>  130

Lys Ala Ser Gln Asp Val Ser Thr Ala Val Ala 
1               5                   10      


<210>  131
<211>  7
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic light chain CDR2 for Hu106-222

<400>  131

Ser Ala Ser Tyr Leu Tyr Thr 
1               5           


<210>  132
<211>  9
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic light chain CDR3 for Hu106-222

<400>  132

Gln Gln His Tyr Ser Thr Pro Arg Thr 
1               5                   


<210>  133
<211>  183
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic OX40L

<400>  133

Met Glu Arg Val Gln Pro Leu Glu Glu Asn Val Gly Asn Ala Ala Arg 
1               5                   10                  15      


Pro Arg Phe Glu Arg Asn Lys Leu Leu Leu Val Ala Ser Val Ile Gln 
            20                  25                  30          


Gly Leu Gly Leu Leu Leu Cys Phe Thr Tyr Ile Cys Leu His Phe Ser 
        35                  40                  45              


Ala Leu Gln Val Ser His Arg Tyr Pro Arg Ile Gln Ser Ile Lys Val 
    50                  55                  60                  


Gln Phe Thr Glu Tyr Lys Lys Glu Lys Gly Phe Ile Leu Thr Ser Gln 
65                  70                  75                  80  


Lys Glu Asp Glu Ile Met Lys Val Gln Asn Asn Ser Val Ile Ile Asn 
                85                  90                  95      


Cys Asp Gly Phe Tyr Leu Ile Ser Leu Lys Gly Tyr Phe Ser Gln Glu 
            100                 105                 110         


Val Asn Ile Ser Leu His Tyr Gln Lys Asp Glu Glu Pro Leu Phe Gln 
        115                 120                 125             


Leu Lys Lys Val Arg Ser Val Asn Ser Leu Met Val Ala Ser Leu Thr 
    130                 135                 140                 


Tyr Lys Asp Lys Val Tyr Leu Asn Val Thr Thr Asp Asn Thr Ser Leu 
145                 150                 155                 160 


Asp Asp Phe His Val Asn Gly Gly Glu Leu Ile Leu Ile His Gln Asn 
                165                 170                 175     


Pro Gly Glu Phe Cys Val Leu 
            180             


<210>  134
<211>  131
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic OX40L soluble domain

<400>  134

Ser His Arg Tyr Pro Arg Ile Gln Ser Ile Lys Val Gln Phe Thr Glu 
1               5                   10                  15      


Tyr Lys Lys Glu Lys Gly Phe Ile Leu Thr Ser Gln Lys Glu Asp Glu 
            20                  25                  30          


Ile Met Lys Val Gln Asn Asn Ser Val Ile Ile Asn Cys Asp Gly Phe 
        35                  40                  45              


Tyr Leu Ile Ser Leu Lys Gly Tyr Phe Ser Gln Glu Val Asn Ile Ser 
    50                  55                  60                  


Leu His Tyr Gln Lys Asp Glu Glu Pro Leu Phe Gln Leu Lys Lys Val 
65                  70                  75                  80  


Arg Ser Val Asn Ser Leu Met Val Ala Ser Leu Thr Tyr Lys Asp Lys 
                85                  90                  95      


Val Tyr Leu Asn Val Thr Thr Asp Asn Thr Ser Leu Asp Asp Phe His 
            100                 105                 110         


Val Asn Gly Gly Glu Leu Ile Leu Ile His Gln Asn Pro Gly Glu Phe 
        115                 120                 125             


Cys Val Leu 
    130     


<210>  135
<211>  128
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic OX40L soluble domain (alternative)

<400>  135

Tyr Pro Arg Ile Gln Ser Ile Lys Val Gln Phe Thr Glu Tyr Lys Lys 
1               5                   10                  15      


Glu Lys Gly Phe Ile Leu Thr Ser Gln Lys Glu Asp Glu Ile Met Lys 
            20                  25                  30          


Val Gln Asn Asn Ser Val Ile Ile Asn Cys Asp Gly Phe Tyr Leu Ile 
        35                  40                  45              


Ser Leu Lys Gly Tyr Phe Ser Gln Glu Val Asn Ile Ser Leu His Tyr 
    50                  55                  60                  


Gln Lys Asp Glu Glu Pro Leu Phe Gln Leu Lys Lys Val Arg Ser Val 
65                  70                  75                  80  


Asn Ser Leu Met Val Ala Ser Leu Thr Tyr Lys Asp Lys Val Tyr Leu 
                85                  90                  95      


Asn Val Thr Thr Asp Asn Thr Ser Leu Asp Asp Phe His Val Asn Gly 
            100                 105                 110         


Gly Glu Leu Ile Leu Ile His Gln Asn Pro Gly Glu Phe Cys Val Leu 
        115                 120                 125             


<210>  136
<211>  120
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic variable heavy chain for 008

<400>  136

Glu Val Gln Leu Val Glu Ser Gly Gly Gly Leu Val Gln Pro Gly Gly 
1               5                   10                  15      


Ser Leu Arg Leu Ser Cys Ala Ala Ser Gly Phe Thr Phe Ser Asn Tyr 
            20                  25                  30          


Thr Met Asn Trp Val Arg Gln Ala Pro Gly Lys Gly Leu Glu Trp Val 
        35                  40                  45              


Ser Ala Ile Ser Gly Ser Gly Gly Ser Thr Tyr Tyr Ala Asp Ser Val 
    50                  55                  60                  


Lys Gly Arg Phe Thr Ile Ser Arg Asp Asn Ser Lys Asn Thr Leu Tyr 
65                  70                  75                  80  


Leu Gln Met Asn Ser Leu Arg Ala Glu Asp Thr Ala Val Tyr Tyr Cys 
                85                  90                  95      


Ala Lys Asp Arg Tyr Ser Gln Val His Tyr Ala Leu Asp Tyr Trp Gly 
            100                 105                 110         


Gln Gly Thr Leu Val Thr Val Ser 
        115                 120 


<210>  137
<211>  108
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic variable light chain for 008

<400>  137

Asp Ile Val Met Thr Gln Ser Pro Asp Ser Leu Pro Val Thr Pro Gly 
1               5                   10                  15      


Glu Pro Ala Ser Ile Ser Cys Arg Ser Ser Gln Ser Leu Leu His Ser 
            20                  25                  30          


Asn Gly Tyr Asn Tyr Leu Asp Trp Tyr Leu Gln Lys Ala Gly Gln Ser 
        35                  40                  45              


Pro Gln Leu Leu Ile Tyr Leu Gly Ser Asn Arg Ala Ser Gly Val Pro 
    50                  55                  60                  


Asp Arg Phe Ser Gly Ser Gly Ser Gly Thr Asp Phe Thr Leu Lys Ile 
65                  70                  75                  80  


Ser Arg Val Glu Ala Glu Asp Val Gly Val Tyr Tyr Cys Gln Gln Tyr 
                85                  90                  95      


Tyr Asn His Pro Thr Thr Phe Gly Gln Gly Thr Lys 
            100                 105             


<210>  138
<211>  120
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic variable heavy chain for 011

<400>  138

Glu Val Gln Leu Val Glu Ser Gly Gly Gly Val Val Gln Pro Gly Arg 
1               5                   10                  15      


Ser Leu Arg Leu Ser Cys Ala Ala Ser Gly Phe Thr Phe Ser Asp Tyr 
            20                  25                  30          


Thr Met Asn Trp Val Arg Gln Ala Pro Gly Lys Gly Leu Glu Trp Val 
        35                  40                  45              


Ser Ser Ile Ser Gly Gly Ser Thr Tyr Tyr Ala Asp Ser Arg Lys Gly 
    50                  55                  60                  


Arg Phe Thr Ile Ser Arg Asp Asn Ser Lys Asn Thr Leu Tyr Leu Gln 
65                  70                  75                  80  


Met Asn Asn Leu Arg Ala Glu Asp Thr Ala Val Tyr Tyr Cys Ala Arg 
                85                  90                  95      


Asp Arg Tyr Phe Arg Gln Gln Asn Ala Phe Asp Tyr Trp Gly Gln Gly 
            100                 105                 110         


Thr Leu Val Thr Val Ser Ser Ala 
        115                 120 


<210>  139
<211>  108
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic variable light chain for 011

<400>  139

Asp Ile Val Met Thr Gln Ser Pro Asp Ser Leu Pro Val Thr Pro Gly 
1               5                   10                  15      


Glu Pro Ala Ser Ile Ser Cys Arg Ser Ser Gln Ser Leu Leu His Ser 
            20                  25                  30          


Asn Gly Tyr Asn Tyr Leu Asp Trp Tyr Leu Gln Lys Ala Gly Gln Ser 
        35                  40                  45              


Pro Gln Leu Leu Ile Tyr Leu Gly Ser Asn Arg Ala Ser Gly Val Pro 
    50                  55                  60                  


Asp Arg Phe Ser Gly Ser Gly Ser Gly Thr Asp Phe Thr Leu Lys Ile 
65                  70                  75                  80  


Ser Arg Val Glu Ala Glu Asp Val Gly Val Tyr Tyr Cys Gln Gln Tyr 
                85                  90                  95      


Tyr Asn His Pro Thr Thr Phe Gly Gln Gly Thr Lys 
            100                 105             


<210>  140
<211>  120
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic variable heavy chain for 021

<400>  140

Glu Val Gln Leu Val Glu Ser Gly Gly Gly Leu Val Gln Pro Arg Gly 
1               5                   10                  15      


Ser Leu Arg Leu Ser Cys Ala Ala Ser Gly Phe Thr Phe Ser Ser Tyr 
            20                  25                  30          


Ala Met Asn Trp Val Arg Gln Ala Pro Gly Lys Gly Leu Glu Trp Val 
        35                  40                  45              


Ala Val Ile Ser Tyr Asp Gly Ser Asn Lys Tyr Tyr Ala Asp Ser Val 
    50                  55                  60                  


Lys Gly Arg Phe Thr Ile Ser Arg Asp Asn Ser Lys Asn Thr Leu Tyr 
65                  70                  75                  80  


Leu Gln Met Asn Ser Leu Arg Ala Glu Asp Thr Ala Val Tyr Tyr Cys 
                85                  90                  95      


Ala Lys Asp Arg Tyr Ile Thr Leu Pro Asn Ala Leu Asp Tyr Trp Gly 
            100                 105                 110         


Gln Gly Thr Leu Val Thr Val Ser 
        115                 120 


<210>  141
<211>  108
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic variable light chain for 021

<400>  141

Asp Ile Gln Met Thr Gln Ser Pro Val Ser Leu Pro Val Thr Pro Gly 
1               5                   10                  15      


Glu Pro Ala Ser Ile Ser Cys Arg Ser Ser Gln Ser Leu Leu His Ser 
            20                  25                  30          


Asn Gly Tyr Asn Tyr Leu Asp Trp Tyr Leu Gln Lys Pro Gly Gln Ser 
        35                  40                  45              


Pro Gln Leu Leu Ile Tyr Leu Gly Ser Asn Arg Ala Ser Gly Val Pro 
    50                  55                  60                  


Asp Arg Phe Ser Gly Ser Gly Ser Gly Thr Asp Phe Thr Leu Lys Ile 
65                  70                  75                  80  


Ser Arg Val Glu Ala Glu Asp Val Gly Val Tyr Tyr Cys Gln Gln Tyr 
                85                  90                  95      


Lys Ser Asn Pro Pro Thr Phe Gly Gln Gly Thr Lys 
            100                 105             


<210>  142
<211>  120
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic variable heavy chain for 023

<400>  142

Glu Val Gln Leu Val Glu Ser Gly Gly Gly Leu Val His Pro Gly Gly 
1               5                   10                  15      


Ser Leu Arg Leu Ser Cys Ala Gly Ser Gly Phe Thr Phe Ser Ser Tyr 
            20                  25                  30          


Ala Met His Trp Val Arg Gln Ala Pro Gly Lys Gly Leu Glu Trp Val 
        35                  40                  45              


Ser Ala Ile Gly Thr Gly Gly Gly Thr Tyr Tyr Ala Asp Ser Val Met 
    50                  55                  60                  


Gly Arg Phe Thr Ile Ser Arg Asp Asn Ser Lys Asn Thr Leu Tyr Leu 
65                  70                  75                  80  


Gln Met Asn Ser Leu Arg Ala Glu Asp Thr Ala Val Tyr Tyr Cys Ala 
                85                  90                  95      


Arg Tyr Asp Asn Val Met Gly Leu Tyr Trp Phe Asp Tyr Trp Gly Gln 
            100                 105                 110         


Gly Thr Leu Val Thr Val Ser Ser 
        115                 120 


<210>  143
<211>  108
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic variable light chain for 023

<400>  143

Glu Ile Val Leu Thr Gln Ser Pro Ala Thr Leu Ser Leu Ser Pro Gly 
1               5                   10                  15      


Glu Arg Ala Thr Leu Ser Cys Arg Ala Ser Gln Ser Val Ser Ser Tyr 
            20                  25                  30          


Leu Ala Trp Tyr Gln Gln Lys Pro Gly Gln Ala Pro Arg Leu Leu Ile 
        35                  40                  45              


Tyr Asp Ala Ser Asn Arg Ala Thr Gly Ile Pro Ala Arg Phe Ser Gly 
    50                  55                  60                  


Ser Gly Ser Gly Thr Asp Phe Thr Leu Thr Ile Ser Ser Leu Glu Pro 
65                  70                  75                  80  


Glu Asp Phe Ala Val Tyr Tyr Cys Gln Gln Arg Ser Asn Trp Pro Pro 
                85                  90                  95      


Ala Phe Gly Gly Gly Thr Lys Val Glu Ile Lys Arg 
            100                 105             


<210>  144
<211>  119
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic heavy chain variable region

<400>  144

Glu Val Gln Leu Gln Gln Ser Gly Pro Glu Leu Val Lys Pro Gly Ala 
1               5                   10                  15      


Ser Val Lys Met Ser Cys Lys Ala Ser Gly Tyr Thr Phe Thr Ser Tyr 
            20                  25                  30          


Val Met His Trp Val Lys Gln Lys Pro Gly Gln Gly Leu Glu Trp Ile 
        35                  40                  45              


Gly Tyr Ile Asn Pro Tyr Asn Asp Gly Thr Lys Tyr Asn Glu Lys Phe 
    50                  55                  60                  


Lys Gly Lys Ala Thr Leu Thr Ser Asp Lys Ser Ser Ser Thr Ala Tyr 
65                  70                  75                  80  


Met Glu Leu Ser Ser Leu Thr Ser Glu Asp Ser Ala Val Tyr Tyr Cys 
                85                  90                  95      


Ala Asn Tyr Tyr Gly Ser Ser Leu Ser Met Asp Tyr Trp Gly Gln Gly 
            100                 105                 110         


Thr Ser Val Thr Val Ser Ser 
        115                 


<210>  145
<211>  108
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic light chain variable region

<400>  145

Asp Ile Gln Met Thr Gln Thr Thr Ser Ser Leu Ser Ala Ser Leu Gly 
1               5                   10                  15      


Asp Arg Val Thr Ile Ser Cys Arg Ala Ser Gln Asp Ile Ser Asn Tyr 
            20                  25                  30          


Leu Asn Trp Tyr Gln Gln Lys Pro Asp Gly Thr Val Lys Leu Leu Ile 
        35                  40                  45              


Tyr Tyr Thr Ser Arg Leu His Ser Gly Val Pro Ser Arg Phe Ser Gly 
    50                  55                  60                  


Ser Gly Ser Gly Thr Asp Tyr Ser Leu Thr Ile Ser Asn Leu Glu Gln 
65                  70                  75                  80  


Glu Asp Ile Ala Thr Tyr Phe Cys Gln Gln Gly Asn Thr Leu Pro Trp 
                85                  90                  95      


Thr Phe Gly Gly Gly Thr Lys Leu Glu Ile Lys Arg 
            100                 105             


<210>  146
<211>  121
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic heavy chain variable region

<400>  146

Glu Val Gln Leu Gln Gln Ser Gly Pro Glu Leu Val Lys Pro Gly Ala 
1               5                   10                  15      


Ser Val Lys Ile Ser Cys Lys Thr Ser Gly Tyr Thr Phe Lys Asp Tyr 
            20                  25                  30          


Thr Met His Trp Val Lys Gln Ser His Gly Lys Ser Leu Glu Trp Ile 
        35                  40                  45              


Gly Gly Ile Tyr Pro Asn Asn Gly Gly Ser Thr Tyr Asn Gln Asn Phe 
    50                  55                  60                  


Lys Asp Lys Ala Thr Leu Thr Val Asp Lys Ser Ser Ser Thr Ala Tyr 
65                  70                  75                  80  


Met Glu Phe Arg Ser Leu Thr Ser Glu Asp Ser Ala Val Tyr Tyr Cys 
                85                  90                  95      


Ala Arg Met Gly Tyr His Gly Pro His Leu Asp Phe Asp Val Trp Gly 
            100                 105                 110         


Ala Gly Thr Thr Val Thr Val Ser Pro 
        115                 120     


<210>  147
<211>  108
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic light chain variable region

<400>  147

Asp Ile Val Met Thr Gln Ser His Lys Phe Met Ser Thr Ser Leu Gly 
1               5                   10                  15      


Asp Arg Val Ser Ile Thr Cys Lys Ala Ser Gln Asp Val Gly Ala Ala 
            20                  25                  30          


Val Ala Trp Tyr Gln Gln Lys Pro Gly Gln Ser Pro Lys Leu Leu Ile 
        35                  40                  45              


Tyr Trp Ala Ser Thr Arg His Thr Gly Val Pro Asp Arg Phe Thr Gly 
    50                  55                  60                  


Gly Gly Ser Gly Thr Asp Phe Thr Leu Thr Ile Ser Asn Val Gln Ser 
65                  70                  75                  80  


Glu Asp Leu Thr Asp Tyr Phe Cys Gln Gln Tyr Ile Asn Tyr Pro Leu 
                85                  90                  95      


Thr Phe Gly Gly Gly Thr Lys Leu Glu Ile Lys Arg 
            100                 105             


<210>  148
<211>  122
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic heavy chain variable region of humanized antibody

<400>  148

Gln Ile Gln Leu Val Gln Ser Gly Pro Glu Leu Lys Lys Pro Gly Glu 
1               5                   10                  15      


Thr Val Lys Ile Ser Cys Lys Ala Ser Gly Tyr Thr Phe Thr Asp Tyr 
            20                  25                  30          


Ser Met His Trp Val Lys Gln Ala Pro Gly Lys Gly Leu Lys Trp Met 
        35                  40                  45              


Gly Trp Ile Asn Thr Glu Thr Gly Glu Pro Thr Tyr Ala Asp Asp Phe 
    50                  55                  60                  


Lys Gly Arg Phe Ala Phe Ser Leu Glu Thr Ser Ala Ser Thr Ala Tyr 
65                  70                  75                  80  


Leu Gln Ile Asn Asn Leu Lys Asn Glu Asp Thr Ala Thr Tyr Phe Cys 
                85                  90                  95      


Ala Asn Pro Tyr Tyr Asp Tyr Val Ser Tyr Tyr Ala Met Asp Tyr Trp 
            100                 105                 110         


Gly His Gly Thr Ser Val Thr Val Ser Ser 
        115                 120         


<210>  149
<211>  122
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic heavy chain variable region of humanized antibody

<400>  149

Gln Val Gln Leu Val Gln Ser Gly Ser Glu Leu Lys Lys Pro Gly Ala 
1               5                   10                  15      


Ser Val Lys Val Ser Cys Lys Ala Ser Gly Tyr Thr Phe Thr Asp Tyr 
            20                  25                  30          


Ser Met His Trp Val Arg Gln Ala Pro Gly Gln Gly Leu Lys Trp Met 
        35                  40                  45              


Gly Trp Ile Asn Thr Glu Thr Gly Glu Pro Thr Tyr Ala Asp Asp Phe 
    50                  55                  60                  


Lys Gly Arg Phe Val Phe Ser Leu Asp Thr Ser Val Ser Thr Ala Tyr 
65                  70                  75                  80  


Leu Gln Ile Ser Ser Leu Lys Ala Glu Asp Thr Ala Val Tyr Tyr Cys 
                85                  90                  95      


Ala Asn Pro Tyr Tyr Asp Tyr Val Ser Tyr Tyr Ala Met Asp Tyr Trp 
            100                 105                 110         


Gly Gln Gly Thr Thr Val Thr Val Ser Ser 
        115                 120         


<210>  150
<211>  107
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic light chain variable region of humanized antibody

<400>  150

Asp Ile Val Met Thr Gln Ser His Lys Phe Met Ser Thr Ser Val Arg 
1               5                   10                  15      


Asp Arg Val Ser Ile Thr Cys Lys Ala Ser Gln Asp Val Ser Thr Ala 
            20                  25                  30          


Val Ala Trp Tyr Gln Gln Lys Pro Gly Gln Ser Pro Lys Leu Leu Ile 
        35                  40                  45              


Tyr Ser Ala Ser Tyr Leu Tyr Thr Gly Val Pro Asp Arg Phe Thr Gly 
    50                  55                  60                  


Ser Gly Ser Gly Thr Asp Phe Thr Phe Thr Ile Ser Ser Val Gln Ala 
65                  70                  75                  80  


Glu Asp Leu Ala Val Tyr Tyr Cys Gln Gln His Tyr Ser Thr Pro Arg 
                85                  90                  95      


Thr Phe Gly Gly Gly Thr Lys Leu Glu Ile Lys 
            100                 105         


<210>  151
<211>  107
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic light chain variable region of humanized antibody

<400>  151

Asp Ile Val Met Thr Gln Ser His Lys Phe Met Ser Thr Ser Val Arg 
1               5                   10                  15      


Asp Arg Val Ser Ile Thr Cys Lys Ala Ser Gln Asp Val Ser Thr Ala 
            20                  25                  30          


Val Ala Trp Tyr Gln Gln Lys Pro Gly Gln Ser Pro Lys Leu Leu Ile 
        35                  40                  45              


Tyr Ser Ala Ser Tyr Leu Tyr Thr Gly Val Pro Asp Arg Phe Thr Gly 
    50                  55                  60                  


Ser Gly Ser Gly Thr Asp Phe Thr Phe Thr Ile Ser Ser Val Gln Ala 
65                  70                  75                  80  


Glu Asp Leu Ala Val Tyr Tyr Cys Gln Gln His Tyr Ser Thr Pro Arg 
                85                  90                  95      


Thr Phe Gly Gly Gly Thr Lys Leu Glu Ile Lys 
            100                 105         


<210>  152
<211>  120
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic heavy chain variable region of humanized antibody

<400>  152

Glu Val Gln Leu Val Glu Ser Gly Gly Gly Leu Val Gln Pro Gly Glu 
1               5                   10                  15      


Ser Leu Lys Leu Ser Cys Glu Ser Asn Glu Tyr Glu Phe Pro Ser His 
            20                  25                  30          


Asp Met Ser Trp Val Arg Lys Thr Pro Glu Lys Arg Leu Glu Leu Val 
        35                  40                  45              


Ala Ala Ile Asn Ser Asp Gly Gly Ser Thr Tyr Tyr Pro Asp Thr Met 
    50                  55                  60                  


Glu Arg Arg Phe Ile Ile Ser Arg Asp Asn Thr Lys Lys Thr Leu Tyr 
65                  70                  75                  80  


Leu Gln Met Ser Ser Leu Arg Ser Glu Asp Thr Ala Leu Tyr Tyr Cys 
                85                  90                  95      


Ala Arg His Tyr Asp Asp Tyr Tyr Ala Trp Phe Ala Tyr Trp Gly Gln 
            100                 105                 110         


Gly Thr Leu Val Thr Val Ser Ala 
        115                 120 


<210>  153
<211>  120
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic heavy chain variable region of humanized antibody

<400>  153

Glu Val Gln Leu Val Glu Ser Gly Gly Gly Leu Val Gln Pro Gly Gly 
1               5                   10                  15      


Ser Leu Arg Leu Ser Cys Ala Ala Ser Glu Tyr Glu Phe Pro Ser His 
            20                  25                  30          


Asp Met Ser Trp Val Arg Gln Ala Pro Gly Lys Gly Leu Glu Leu Val 
        35                  40                  45              


Ala Ala Ile Asn Ser Asp Gly Gly Ser Thr Tyr Tyr Pro Asp Thr Met 
    50                  55                  60                  


Glu Arg Arg Phe Thr Ile Ser Arg Asp Asn Ala Lys Asn Ser Leu Tyr 
65                  70                  75                  80  


Leu Gln Met Asn Ser Leu Arg Ala Glu Asp Thr Ala Val Tyr Tyr Cys 
                85                  90                  95      


Ala Arg His Tyr Asp Asp Tyr Tyr Ala Trp Phe Ala Tyr Trp Gly Gln 
            100                 105                 110         


Gly Thr Met Val Thr Val Ser Ser 
        115                 120 


<210>  154
<211>  111
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic light chain variable region of humanized antibody

<400>  154

Asp Ile Val Leu Thr Gln Ser Pro Ala Ser Leu Ala Val Ser Leu Gly 
1               5                   10                  15      


Gln Arg Ala Thr Ile Ser Cys Arg Ala Ser Lys Ser Val Ser Thr Ser 
            20                  25                  30          


Gly Tyr Ser Tyr Met His Trp Tyr Gln Gln Lys Pro Gly Gln Pro Pro 
        35                  40                  45              


Lys Leu Leu Ile Tyr Leu Ala Ser Asn Leu Glu Ser Gly Val Pro Ala 
    50                  55                  60                  


Arg Phe Ser Gly Ser Gly Ser Gly Thr Asp Phe Thr Leu Asn Ile His 
65                  70                  75                  80  


Pro Val Glu Glu Glu Asp Ala Ala Thr Tyr Tyr Cys Gln His Ser Arg 
                85                  90                  95      


Glu Leu Pro Leu Thr Phe Gly Ala Gly Thr Lys Leu Glu Leu Lys 
            100                 105                 110     


<210>  155
<211>  111
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic light chain variable region of humanized antibody

<400>  155

Glu Ile Val Leu Thr Gln Ser Pro Ala Thr Leu Ser Leu Ser Pro Gly 
1               5                   10                  15      


Glu Arg Ala Thr Leu Ser Cys Arg Ala Ser Lys Ser Val Ser Thr Ser 
            20                  25                  30          


Gly Tyr Ser Tyr Met His Trp Tyr Gln Gln Lys Pro Gly Gln Ala Pro 
        35                  40                  45              


Arg Leu Leu Ile Tyr Leu Ala Ser Asn Leu Glu Ser Gly Val Pro Ala 
    50                  55                  60                  


Arg Phe Ser Gly Ser Gly Ser Gly Thr Asp Phe Thr Leu Thr Ile Ser 
65                  70                  75                  80  


Ser Leu Glu Pro Glu Asp Phe Ala Val Tyr Tyr Cys Gln His Ser Arg 
                85                  90                  95      


Glu Leu Pro Leu Thr Phe Gly Gly Gly Thr Lys Val Glu Ile Lys 
            100                 105                 110     


<210>  156
<211>  138
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic heavy chain variable region

<400>  156

Met Tyr Leu Gly Leu Asn Tyr Val Phe Ile Val Phe Leu Leu Asn Gly 
1               5                   10                  15      


Val Gln Ser Glu Val Lys Leu Glu Glu Ser Gly Gly Gly Leu Val Gln 
            20                  25                  30          


Pro Gly Gly Ser Met Lys Leu Ser Cys Ala Ala Ser Gly Phe Thr Phe 
        35                  40                  45              


Ser Asp Ala Trp Met Asp Trp Val Arg Gln Ser Pro Glu Lys Gly Leu 
    50                  55                  60                  


Glu Trp Val Ala Glu Ile Arg Ser Lys Ala Asn Asn His Ala Thr Tyr 
65                  70                  75                  80  


Tyr Ala Glu Ser Val Asn Gly Arg Phe Thr Ile Ser Arg Asp Asp Ser 
                85                  90                  95      


Lys Ser Ser Val Tyr Leu Gln Met Asn Ser Leu Arg Ala Glu Asp Thr 
            100                 105                 110         


Gly Ile Tyr Tyr Cys Thr Trp Gly Glu Val Phe Tyr Phe Asp Tyr Trp 
        115                 120                 125             


Gly Gln Gly Thr Thr Leu Thr Val Ser Ser 
    130                 135             


<210>  157
<211>  126
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic light chain variable region

<400>  157

Met Arg Pro Ser Ile Gln Phe Leu Gly Leu Leu Leu Phe Trp Leu His 
1               5                   10                  15      


Gly Ala Gln Cys Asp Ile Gln Met Thr Gln Ser Pro Ser Ser Leu Ser 
            20                  25                  30          


Ala Ser Leu Gly Gly Lys Val Thr Ile Thr Cys Lys Ser Ser Gln Asp 
        35                  40                  45              


Ile Asn Lys Tyr Ile Ala Trp Tyr Gln His Lys Pro Gly Lys Gly Pro 
    50                  55                  60                  


Arg Leu Leu Ile His Tyr Thr Ser Thr Leu Gln Pro Gly Ile Pro Ser 
65                  70                  75                  80  


Arg Phe Ser Gly Ser Gly Ser Gly Arg Asp Tyr Ser Phe Ser Ile Ser 
                85                  90                  95      


Asn Leu Glu Pro Glu Asp Ile Ala Thr Tyr Tyr Cys Leu Gln Tyr Asp 
            100                 105                 110         


Asn Leu Leu Thr Phe Gly Ala Gly Thr Lys Leu Glu Leu Lys 
        115                 120                 125     


<210>  158
<211>  440
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic nivolumab heavy chain

<400>  158

Gln Val Gln Leu Val Glu Ser Gly Gly Gly Val Val Gln Pro Gly Arg 
1               5                   10                  15      


Ser Leu Arg Leu Asp Cys Lys Ala Ser Gly Ile Thr Phe Ser Asn Ser 
            20                  25                  30          


Gly Met His Trp Val Arg Gln Ala Pro Gly Lys Gly Leu Glu Trp Val 
        35                  40                  45              


Ala Val Ile Trp Tyr Asp Gly Ser Lys Arg Tyr Tyr Ala Asp Ser Val 
    50                  55                  60                  


Lys Gly Arg Phe Thr Ile Ser Arg Asp Asn Ser Lys Asn Thr Leu Phe 
65                  70                  75                  80  


Leu Gln Met Asn Ser Leu Arg Ala Glu Asp Thr Ala Val Tyr Tyr Cys 
                85                  90                  95      


Ala Thr Asn Asp Asp Tyr Trp Gly Gln Gly Thr Leu Val Thr Val Ser 
            100                 105                 110         


Ser Ala Ser Thr Lys Gly Pro Ser Val Phe Pro Leu Ala Pro Cys Ser 
        115                 120                 125             


Arg Ser Thr Ser Glu Ser Thr Ala Ala Leu Gly Cys Leu Val Lys Asp 
    130                 135                 140                 


Tyr Phe Pro Glu Pro Val Thr Val Ser Trp Asn Ser Gly Ala Leu Thr 
145                 150                 155                 160 


Ser Gly Val His Thr Phe Pro Ala Val Leu Gln Ser Ser Gly Leu Tyr 
                165                 170                 175     


Ser Leu Ser Ser Val Val Thr Val Pro Ser Ser Ser Leu Gly Thr Lys 
            180                 185                 190         


Thr Tyr Thr Cys Asn Val Asp His Lys Pro Ser Asn Thr Lys Val Asp 
        195                 200                 205             


Lys Arg Val Glu Ser Lys Tyr Gly Pro Pro Cys Pro Pro Cys Pro Ala 
    210                 215                 220                 


Pro Glu Phe Leu Gly Gly Pro Ser Val Phe Leu Phe Pro Pro Lys Pro 
225                 230                 235                 240 


Lys Asp Thr Leu Met Ile Ser Arg Thr Pro Glu Val Thr Cys Val Val 
                245                 250                 255     


Val Asp Val Ser Gln Glu Asp Pro Glu Val Gln Phe Asn Trp Tyr Val 
            260                 265                 270         


Asp Gly Val Glu Val His Asn Ala Lys Thr Lys Pro Arg Glu Glu Gln 
        275                 280                 285             


Phe Asn Ser Thr Tyr Arg Val Val Ser Val Leu Thr Val Leu His Gln 
    290                 295                 300                 


Asp Trp Leu Asn Gly Lys Glu Tyr Lys Cys Lys Val Ser Asn Lys Gly 
305                 310                 315                 320 


Leu Pro Ser Ser Ile Glu Lys Thr Ile Ser Lys Ala Lys Gly Gln Pro 
                325                 330                 335     


Arg Glu Pro Gln Val Tyr Thr Leu Pro Pro Ser Gln Glu Glu Met Thr 
            340                 345                 350         


Lys Asn Gln Val Ser Leu Thr Cys Leu Val Lys Gly Phe Tyr Pro Ser 
        355                 360                 365             


Asp Ile Ala Val Glu Trp Glu Ser Asn Gly Gln Pro Glu Asn Asn Tyr 
    370                 375                 380                 


Lys Thr Thr Pro Pro Val Leu Asp Ser Asp Gly Ser Phe Phe Leu Tyr 
385                 390                 395                 400 


Ser Arg Leu Thr Val Asp Lys Ser Arg Trp Gln Glu Gly Asn Val Phe 
                405                 410                 415     


Ser Cys Ser Val Met His Glu Ala Leu His Asn His Tyr Thr Gln Lys 
            420                 425                 430         


Ser Leu Ser Leu Ser Leu Gly Lys 
        435                 440 


<210>  159
<211>  214
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic nivolumab light chain

<400>  159

Glu Ile Val Leu Thr Gln Ser Pro Ala Thr Leu Ser Leu Ser Pro Gly 
1               5                   10                  15      


Glu Arg Ala Thr Leu Ser Cys Arg Ala Ser Gln Ser Val Ser Ser Tyr 
            20                  25                  30          


Leu Ala Trp Tyr Gln Gln Lys Pro Gly Gln Ala Pro Arg Leu Leu Ile 
        35                  40                  45              


Tyr Asp Ala Ser Asn Arg Ala Thr Gly Ile Pro Ala Arg Phe Ser Gly 
    50                  55                  60                  


Ser Gly Ser Gly Thr Asp Phe Thr Leu Thr Ile Ser Ser Leu Glu Pro 
65                  70                  75                  80  


Glu Asp Phe Ala Val Tyr Tyr Cys Gln Gln Ser Ser Asn Trp Pro Arg 
                85                  90                  95      


Thr Phe Gly Gln Gly Thr Lys Val Glu Ile Lys Arg Thr Val Ala Ala 
            100                 105                 110         


Pro Ser Val Phe Ile Phe Pro Pro Ser Asp Glu Gln Leu Lys Ser Gly 
        115                 120                 125             


Thr Ala Ser Val Val Cys Leu Leu Asn Asn Phe Tyr Pro Arg Glu Ala 
    130                 135                 140                 


Lys Val Gln Trp Lys Val Asp Asn Ala Leu Gln Ser Gly Asn Ser Gln 
145                 150                 155                 160 


Glu Ser Val Thr Glu Gln Asp Ser Lys Asp Ser Thr Tyr Ser Leu Ser 
                165                 170                 175     


Ser Thr Leu Thr Leu Ser Lys Ala Asp Tyr Glu Lys His Lys Val Tyr 
            180                 185                 190         


Ala Cys Glu Val Thr His Gln Gly Leu Ser Ser Pro Val Thr Lys Ser 
        195                 200                 205             


Phe Asn Arg Gly Glu Cys 
    210                 


<210>  160
<211>  113
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic nivolumab variable heavy chain

<400>  160

Gln Val Gln Leu Val Glu Ser Gly Gly Gly Val Val Gln Pro Gly Arg 
1               5                   10                  15      


Ser Leu Arg Leu Asp Cys Lys Ala Ser Gly Ile Thr Phe Ser Asn Ser 
            20                  25                  30          


Gly Met His Trp Val Arg Gln Ala Pro Gly Lys Gly Leu Glu Trp Val 
        35                  40                  45              


Ala Val Ile Trp Tyr Asp Gly Ser Lys Arg Tyr Tyr Ala Asp Ser Val 
    50                  55                  60                  


Lys Gly Arg Phe Thr Ile Ser Arg Asp Asn Ser Lys Asn Thr Leu Phe 
65                  70                  75                  80  


Leu Gln Met Asn Ser Leu Arg Ala Glu Asp Thr Ala Val Tyr Tyr Cys 
                85                  90                  95      


Ala Thr Asn Asp Asp Tyr Trp Gly Gln Gly Thr Leu Val Thr Val Ser 
            100                 105                 110         


Ser 
    


<210>  161
<211>  107
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic nivolumab variable light chain

<400>  161

Glu Ile Val Leu Thr Gln Ser Pro Ala Thr Leu Ser Leu Ser Pro Gly 
1               5                   10                  15      


Glu Arg Ala Thr Leu Ser Cys Arg Ala Ser Gln Ser Val Ser Ser Tyr 
            20                  25                  30          


Leu Ala Trp Tyr Gln Gln Lys Pro Gly Gln Ala Pro Arg Leu Leu Ile 
        35                  40                  45              


Tyr Asp Ala Ser Asn Arg Ala Thr Gly Ile Pro Ala Arg Phe Ser Gly 
    50                  55                  60                  


Ser Gly Ser Gly Thr Asp Phe Thr Leu Thr Ile Ser Ser Leu Glu Pro 
65                  70                  75                  80  


Glu Asp Phe Ala Val Tyr Tyr Cys Gln Gln Ser Ser Asn Trp Pro Arg 
                85                  90                  95      


Thr Phe Gly Gln Gly Thr Lys Val Glu Ile Lys 
            100                 105         


<210>  162
<211>  5
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic nivolumab heavy chain CDR1

<400>  162

Asn Ser Gly Met His 
1               5   


<210>  163
<211>  17
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic nivolumab heavy chain CDR2

<400>  163

Val Ile Trp Tyr Asp Gly Ser Lys Arg Tyr Tyr Ala Asp Ser Val Lys 
1               5                   10                  15      


Gly 
    


<210>  164
<211>  4
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic nivolumab heavy chain CDR3

<400>  164

Asn Asp Asp Tyr 
1               


<210>  165
<211>  11
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic nivolumab light chain CDR1

<400>  165

Arg Ala Ser Gln Ser Val Ser Ser Tyr Leu Ala 
1               5                   10      


<210>  166
<211>  7
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic nivolumab light chain CDR2

<400>  166

Asp Ala Ser Asn Arg Ala Thr 
1               5           


<210>  167
<211>  9
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic nivolumab light chain CDR3

<400>  167

Gln Gln Ser Ser Asn Trp Pro Arg Thr 
1               5                   


<210>  168
<211>  447
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic pembrolizumab heavy chain

<400>  168

Gln Val Gln Leu Val Gln Ser Gly Val Glu Val Lys Lys Pro Gly Ala 
1               5                   10                  15      


Ser Val Lys Val Ser Cys Lys Ala Ser Gly Tyr Thr Phe Thr Asn Tyr 
            20                  25                  30          


Tyr Met Tyr Trp Val Arg Gln Ala Pro Gly Gln Gly Leu Glu Trp Met 
        35                  40                  45              


Gly Gly Ile Asn Pro Ser Asn Gly Gly Thr Asn Phe Asn Glu Lys Phe 
    50                  55                  60                  


Lys Asn Arg Val Thr Leu Thr Thr Asp Ser Ser Thr Thr Thr Ala Tyr 
65                  70                  75                  80  


Met Glu Leu Lys Ser Leu Gln Phe Asp Asp Thr Ala Val Tyr Tyr Cys 
                85                  90                  95      


Ala Arg Arg Asp Tyr Arg Phe Asp Met Gly Phe Asp Tyr Trp Gly Gln 
            100                 105                 110         


Gly Thr Thr Val Thr Val Ser Ser Ala Ser Thr Lys Gly Pro Ser Val 
        115                 120                 125             


Phe Pro Leu Ala Pro Cys Ser Arg Ser Thr Ser Glu Ser Thr Ala Ala 
    130                 135                 140                 


Leu Gly Cys Leu Val Lys Asp Tyr Phe Pro Glu Pro Val Thr Val Ser 
145                 150                 155                 160 


Trp Asn Ser Gly Ala Leu Thr Ser Gly Val His Thr Phe Pro Ala Val 
                165                 170                 175     


Leu Gln Ser Ser Gly Leu Tyr Ser Leu Ser Ser Val Val Thr Val Pro 
            180                 185                 190         


Ser Ser Ser Leu Gly Thr Lys Thr Tyr Thr Cys Asn Val Asp His Lys 
        195                 200                 205             


Pro Ser Asn Thr Lys Val Asp Lys Arg Val Glu Ser Lys Tyr Gly Pro 
    210                 215                 220                 


Pro Cys Pro Pro Cys Pro Ala Pro Glu Phe Leu Gly Gly Pro Ser Val 
225                 230                 235                 240 


Phe Leu Phe Pro Pro Lys Pro Lys Asp Thr Leu Met Ile Ser Arg Thr 
                245                 250                 255     


Pro Glu Val Thr Cys Val Val Val Asp Val Ser Gln Glu Asp Pro Glu 
            260                 265                 270         


Val Gln Phe Asn Trp Tyr Val Asp Gly Val Glu Val His Asn Ala Lys 
        275                 280                 285             


Thr Lys Pro Arg Glu Glu Gln Phe Asn Ser Thr Tyr Arg Val Val Ser 
    290                 295                 300                 


Val Leu Thr Val Leu His Gln Asp Trp Leu Asn Gly Lys Glu Tyr Lys 
305                 310                 315                 320 


Cys Lys Val Ser Asn Lys Gly Leu Pro Ser Ser Ile Glu Lys Thr Ile 
                325                 330                 335     


Ser Lys Ala Lys Gly Gln Pro Arg Glu Pro Gln Val Tyr Thr Leu Pro 
            340                 345                 350         


Pro Ser Gln Glu Glu Met Thr Lys Asn Gln Val Ser Leu Thr Cys Leu 
        355                 360                 365             


Val Lys Gly Phe Tyr Pro Ser Asp Ile Ala Val Glu Trp Glu Ser Asn 
    370                 375                 380                 


Gly Gln Pro Glu Asn Asn Tyr Lys Thr Thr Pro Pro Val Leu Asp Ser 
385                 390                 395                 400 


Asp Gly Ser Phe Phe Leu Tyr Ser Arg Leu Thr Val Asp Lys Ser Arg 
                405                 410                 415     


Trp Gln Glu Gly Asn Val Phe Ser Cys Ser Val Met His Glu Ala Leu 
            420                 425                 430         


His Asn His Tyr Thr Gln Lys Ser Leu Ser Leu Ser Leu Gly Lys 
        435                 440                 445         


<210>  169
<211>  218
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic pembrolizumab light chain

<400>  169

Glu Ile Val Leu Thr Gln Ser Pro Ala Thr Leu Ser Leu Ser Pro Gly 
1               5                   10                  15      


Glu Arg Ala Thr Leu Ser Cys Arg Ala Ser Lys Gly Val Ser Thr Ser 
            20                  25                  30          


Gly Tyr Ser Tyr Leu His Trp Tyr Gln Gln Lys Pro Gly Gln Ala Pro 
        35                  40                  45              


Arg Leu Leu Ile Tyr Leu Ala Ser Tyr Leu Glu Ser Gly Val Pro Ala 
    50                  55                  60                  


Arg Phe Ser Gly Ser Gly Ser Gly Thr Asp Phe Thr Leu Thr Ile Ser 
65                  70                  75                  80  


Ser Leu Glu Pro Glu Asp Phe Ala Val Tyr Tyr Cys Gln His Ser Arg 
                85                  90                  95      


Asp Leu Pro Leu Thr Phe Gly Gly Gly Thr Lys Val Glu Ile Lys Arg 
            100                 105                 110         


Thr Val Ala Ala Pro Ser Val Phe Ile Phe Pro Pro Ser Asp Glu Gln 
        115                 120                 125             


Leu Lys Ser Gly Thr Ala Ser Val Val Cys Leu Leu Asn Asn Phe Tyr 
    130                 135                 140                 


Pro Arg Glu Ala Lys Val Gln Trp Lys Val Asp Asn Ala Leu Gln Ser 
145                 150                 155                 160 


Gly Asn Ser Gln Glu Ser Val Thr Glu Gln Asp Ser Lys Asp Ser Thr 
                165                 170                 175     


Tyr Ser Leu Ser Ser Thr Leu Thr Leu Ser Lys Ala Asp Tyr Glu Lys 
            180                 185                 190         


His Lys Val Tyr Ala Cys Glu Val Thr His Gln Gly Leu Ser Ser Pro 
        195                 200                 205             


Val Thr Lys Ser Phe Asn Arg Gly Glu Cys 
    210                 215             


<210>  170
<211>  120
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic pembrolizumab variable heavy chain

<400>  170

Gln Val Gln Leu Val Gln Ser Gly Val Glu Val Lys Lys Pro Gly Ala 
1               5                   10                  15      


Ser Val Lys Val Ser Cys Lys Ala Ser Gly Tyr Thr Phe Thr Asn Tyr 
            20                  25                  30          


Tyr Met Tyr Trp Val Arg Gln Ala Pro Gly Gln Gly Leu Glu Trp Met 
        35                  40                  45              


Gly Gly Ile Asn Pro Ser Asn Gly Gly Thr Asn Phe Asn Glu Lys Phe 
    50                  55                  60                  


Lys Asn Arg Val Thr Leu Thr Thr Asp Ser Ser Thr Thr Thr Ala Tyr 
65                  70                  75                  80  


Met Glu Leu Lys Ser Leu Gln Phe Asp Asp Thr Ala Val Tyr Tyr Cys 
                85                  90                  95      


Ala Arg Arg Asp Tyr Arg Phe Asp Met Gly Phe Asp Tyr Trp Gly Gln 
            100                 105                 110         


Gly Thr Thr Val Thr Val Ser Ser 
        115                 120 


<210>  171
<211>  111
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic pembrolizumab variable light chain

<400>  171

Glu Ile Val Leu Thr Gln Ser Pro Ala Thr Leu Ser Leu Ser Pro Gly 
1               5                   10                  15      


Glu Arg Ala Thr Leu Ser Cys Arg Ala Ser Lys Gly Val Ser Thr Ser 
            20                  25                  30          


Gly Tyr Ser Tyr Leu His Trp Tyr Gln Gln Lys Pro Gly Gln Ala Pro 
        35                  40                  45              


Arg Leu Leu Ile Tyr Leu Ala Ser Tyr Leu Glu Ser Gly Val Pro Ala 
    50                  55                  60                  


Arg Phe Ser Gly Ser Gly Ser Gly Thr Asp Phe Thr Leu Thr Ile Ser 
65                  70                  75                  80  


Ser Leu Glu Pro Glu Asp Phe Ala Val Tyr Tyr Cys Gln His Ser Arg 
                85                  90                  95      


Asp Leu Pro Leu Thr Phe Gly Gly Gly Thr Lys Val Glu Ile Lys 
            100                 105                 110     


<210>  172
<211>  5
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic pembrolizumab heavy chain CDR1

<400>  172

Asn Tyr Tyr Met Tyr 
1               5   


<210>  173
<211>  16
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic pembrolizumab heavy chain CDR2

<400>  173

Gly Ile Asn Pro Ser Asn Gly Gly Thr Asn Phe Asn Glu Lys Phe Lys 
1               5                   10                  15      


<210>  174
<211>  11
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic pembrolizumab heavy chain CDR3

<400>  174

Arg Asp Tyr Arg Phe Asp Met Gly Phe Asp Tyr 
1               5                   10      


<210>  175
<211>  15
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic pembrolizumab light chain CDR1

<400>  175

Arg Ala Ser Lys Gly Val Ser Thr Ser Gly Tyr Ser Tyr Leu His 
1               5                   10                  15  


<210>  176
<211>  7
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic pembrolizumab light chain CDR2

<400>  176

Leu Ala Ser Tyr Leu Glu Ser 
1               5           


<210>  177
<211>  9
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic pembrolizumab light chain CDR3

<400>  177

Gln His Ser Arg Asp Leu Pro Leu Thr 
1               5                   


<210>  178
<211>  451
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic durvalumab heavy chain

<400>  178

Glu Val Gln Leu Val Glu Ser Gly Gly Gly Leu Val Gln Pro Gly Gly 
1               5                   10                  15      


Ser Leu Arg Leu Ser Cys Ala Ala Ser Gly Phe Thr Phe Ser Arg Tyr 
            20                  25                  30          


Trp Met Ser Trp Val Arg Gln Ala Pro Gly Lys Gly Leu Glu Trp Val 
        35                  40                  45              


Ala Asn Ile Lys Gln Asp Gly Ser Glu Lys Tyr Tyr Val Asp Ser Val 
    50                  55                  60                  


Lys Gly Arg Phe Thr Ile Ser Arg Asp Asn Ala Lys Asn Ser Leu Tyr 
65                  70                  75                  80  


Leu Gln Met Asn Ser Leu Arg Ala Glu Asp Thr Ala Val Tyr Tyr Cys 
                85                  90                  95      


Ala Arg Glu Gly Gly Trp Phe Gly Glu Leu Ala Phe Asp Tyr Trp Gly 
            100                 105                 110         


Gln Gly Thr Leu Val Thr Val Ser Ser Ala Ser Thr Lys Gly Pro Ser 
        115                 120                 125             


Val Phe Pro Leu Ala Pro Ser Ser Lys Ser Thr Ser Gly Gly Thr Ala 
    130                 135                 140                 


Ala Leu Gly Cys Leu Val Lys Asp Tyr Phe Pro Glu Pro Val Thr Val 
145                 150                 155                 160 


Ser Trp Asn Ser Gly Ala Leu Thr Ser Gly Val His Thr Phe Pro Ala 
                165                 170                 175     


Val Leu Gln Ser Ser Gly Leu Tyr Ser Leu Ser Ser Val Val Thr Val 
            180                 185                 190         


Pro Ser Ser Ser Leu Gly Thr Gln Thr Tyr Ile Cys Asn Val Asn His 
        195                 200                 205             


Lys Pro Ser Asn Thr Lys Val Asp Lys Arg Val Glu Pro Lys Ser Cys 
    210                 215                 220                 


Asp Lys Thr His Thr Cys Pro Pro Cys Pro Ala Pro Glu Phe Glu Gly 
225                 230                 235                 240 


Gly Pro Ser Val Phe Leu Phe Pro Pro Lys Pro Lys Asp Thr Leu Met 
                245                 250                 255     


Ile Ser Arg Thr Pro Glu Val Thr Cys Val Val Val Asp Val Ser His 
            260                 265                 270         


Glu Asp Pro Glu Val Lys Phe Asn Trp Tyr Val Asp Gly Val Glu Val 
        275                 280                 285             


His Asn Ala Lys Thr Lys Pro Arg Glu Glu Gln Tyr Asn Ser Thr Tyr 
    290                 295                 300                 


Arg Val Val Ser Val Leu Thr Val Leu His Gln Asp Trp Leu Asn Gly 
305                 310                 315                 320 


Lys Glu Tyr Lys Cys Lys Val Ser Asn Lys Ala Leu Pro Ala Ser Ile 
                325                 330                 335     


Glu Lys Thr Ile Ser Lys Ala Lys Gly Gln Pro Arg Glu Pro Gln Val 
            340                 345                 350         


Tyr Thr Leu Pro Pro Ser Arg Glu Glu Met Thr Lys Asn Gln Val Ser 
        355                 360                 365             


Leu Thr Cys Leu Val Lys Gly Phe Tyr Pro Ser Asp Ile Ala Val Glu 
    370                 375                 380                 


Trp Glu Ser Asn Gly Gln Pro Glu Asn Asn Tyr Lys Thr Thr Pro Pro 
385                 390                 395                 400 


Val Leu Asp Ser Asp Gly Ser Phe Phe Leu Tyr Ser Lys Leu Thr Val 
                405                 410                 415     


Asp Lys Ser Arg Trp Gln Gln Gly Asn Val Phe Ser Cys Ser Val Met 
            420                 425                 430         


His Glu Ala Leu His Asn His Tyr Thr Gln Lys Ser Leu Ser Leu Ser 
        435                 440                 445             


Pro Gly Lys 
    450     


<210>  179
<211>  265
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic durvalumab light chain

<400>  179

Glu Val Gln Leu Val Glu Ser Gly Gly Gly Leu Val Gln Pro Gly Gly 
1               5                   10                  15      


Ser Leu Arg Leu Ser Cys Ala Ala Ser Gly Phe Thr Phe Ser Arg Tyr 
            20                  25                  30          


Trp Met Ser Trp Val Arg Gln Ala Pro Gly Lys Gly Leu Glu Trp Val 
        35                  40                  45              


Ala Asn Glu Ile Val Leu Thr Gln Ser Pro Gly Thr Leu Ser Leu Ser 
    50                  55                  60                  


Pro Gly Glu Arg Ala Thr Leu Ser Cys Arg Ala Ser Gln Arg Val Ser 
65                  70                  75                  80  


Ser Ser Tyr Leu Ala Trp Tyr Gln Gln Lys Pro Gly Gln Ala Pro Arg 
                85                  90                  95      


Leu Leu Ile Tyr Asp Ala Ser Ser Arg Ala Thr Gly Ile Pro Asp Arg 
            100                 105                 110         


Phe Ser Gly Ser Gly Ser Gly Thr Asp Phe Thr Leu Thr Ile Ser Arg 
        115                 120                 125             


Leu Glu Pro Glu Asp Phe Ala Val Tyr Tyr Cys Gln Gln Tyr Gly Ser 
    130                 135                 140                 


Leu Pro Trp Thr Phe Gly Gln Gly Thr Lys Val Glu Ile Lys Arg Thr 
145                 150                 155                 160 


Val Ala Ala Pro Ser Val Phe Ile Phe Pro Pro Ser Asp Glu Gln Leu 
                165                 170                 175     


Lys Ser Gly Thr Ala Ser Val Val Cys Leu Leu Asn Asn Phe Tyr Pro 
            180                 185                 190         


Arg Glu Ala Lys Val Gln Trp Lys Val Asp Asn Ala Leu Gln Ser Gly 
        195                 200                 205             


Asn Ser Gln Glu Ser Val Thr Glu Gln Asp Ser Lys Asp Ser Thr Tyr 
    210                 215                 220                 


Ser Leu Ser Ser Thr Leu Thr Leu Ser Lys Ala Asp Tyr Glu Lys His 
225                 230                 235                 240 


Lys Val Tyr Ala Cys Glu Val Thr His Gln Gly Leu Ser Ser Pro Val 
                245                 250                 255     


Thr Lys Ser Phe Asn Arg Gly Glu Cys 
            260                 265 


<210>  180
<211>  121
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic durvalumab variable heavy chain

<400>  180

Glu Val Gln Leu Val Glu Ser Gly Gly Gly Leu Val Gln Pro Gly Gly 
1               5                   10                  15      


Ser Leu Arg Leu Ser Cys Ala Ala Ser Gly Phe Thr Phe Ser Arg Tyr 
            20                  25                  30          


Trp Met Ser Trp Val Arg Gln Ala Pro Gly Lys Gly Leu Glu Trp Val 
        35                  40                  45              


Ala Asn Ile Lys Gln Asp Gly Ser Glu Lys Tyr Tyr Val Asp Ser Val 
    50                  55                  60                  


Lys Gly Arg Phe Thr Ile Ser Arg Asp Asn Ala Lys Asn Ser Leu Tyr 
65                  70                  75                  80  


Leu Gln Met Asn Ser Leu Arg Ala Glu Asp Thr Ala Val Tyr Tyr Cys 
                85                  90                  95      


Ala Arg Glu Gly Gly Trp Phe Gly Glu Leu Ala Phe Asp Tyr Trp Gly 
            100                 105                 110         


Gln Gly Thr Leu Val Thr Val Ser Ser 
        115                 120     


<210>  181
<211>  108
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic durvalumab variable light chain

<400>  181

Glu Ile Val Leu Thr Gln Ser Pro Gly Thr Leu Ser Leu Ser Pro Gly 
1               5                   10                  15      


Glu Arg Ala Thr Leu Ser Cys Arg Ala Ser Gln Arg Val Ser Ser Ser 
            20                  25                  30          


Tyr Leu Ala Trp Tyr Gln Gln Lys Pro Gly Gln Ala Pro Arg Leu Leu 
        35                  40                  45              


Ile Tyr Asp Ala Ser Ser Arg Ala Thr Gly Ile Pro Asp Arg Phe Ser 
    50                  55                  60                  


Gly Ser Gly Ser Gly Thr Asp Phe Thr Leu Thr Ile Ser Arg Leu Glu 
65                  70                  75                  80  


Pro Glu Asp Phe Ala Val Tyr Tyr Cys Gln Gln Tyr Gly Ser Leu Pro 
                85                  90                  95      


Trp Thr Phe Gly Gln Gly Thr Lys Val Glu Ile Lys 
            100                 105             


<210>  182
<211>  5
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic durvalumab heavy chain CDR1

<400>  182

Arg Tyr Trp Met Ser 
1               5   


<210>  183
<211>  17
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic durvalumab heavy chain CDR2

<400>  183

Asn Ile Lys Gln Asp Gly Ser Glu Lys Tyr Tyr Val Asp Ser Val Lys 
1               5                   10                  15      


Gly 
    


<210>  184
<211>  12
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic durvalumab heavy chain CDR3

<400>  184

Glu Gly Gly Trp Phe Gly Glu Leu Ala Phe Asp Tyr 
1               5                   10          


<210>  185
<211>  12
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic durvalumab light chain CDR1

<400>  185

Arg Ala Ser Gln Arg Val Ser Ser Ser Tyr Leu Ala 
1               5                   10          


<210>  186
<211>  7
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic durvalumab light chain CDR2

<400>  186

Asp Ala Ser Ser Arg Ala Thr 
1               5           


<210>  187
<211>  9
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic durvalumab light chain CDR3

<400>  187

Gln Gln Tyr Gly Ser Leu Pro Trp Thr 
1               5                   


<210>  188
<211>  450
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic avelumab heavy chain

<400>  188

Glu Val Gln Leu Leu Glu Ser Gly Gly Gly Leu Val Gln Pro Gly Gly 
1               5                   10                  15      


Ser Leu Arg Leu Ser Cys Ala Ala Ser Gly Phe Thr Phe Ser Ser Tyr 
            20                  25                  30          


Ile Met Met Trp Val Arg Gln Ala Pro Gly Lys Gly Leu Glu Trp Val 
        35                  40                  45              


Ser Ser Ile Tyr Pro Ser Gly Gly Ile Thr Phe Tyr Ala Asp Thr Val 
    50                  55                  60                  


Lys Gly Arg Phe Thr Ile Ser Arg Asp Asn Ser Lys Asn Thr Leu Tyr 
65                  70                  75                  80  


Leu Gln Met Asn Ser Leu Arg Ala Glu Asp Thr Ala Val Tyr Tyr Cys 
                85                  90                  95      


Ala Arg Ile Lys Leu Gly Thr Val Thr Thr Val Asp Tyr Trp Gly Gln 
            100                 105                 110         


Gly Thr Leu Val Thr Val Ser Ser Ala Ser Thr Lys Gly Pro Ser Val 
        115                 120                 125             


Phe Pro Leu Ala Pro Ser Ser Lys Ser Thr Ser Gly Gly Thr Ala Ala 
    130                 135                 140                 


Leu Gly Cys Leu Val Lys Asp Tyr Phe Pro Glu Pro Val Thr Val Ser 
145                 150                 155                 160 


Trp Asn Ser Gly Ala Leu Thr Ser Gly Val His Thr Phe Pro Ala Val 
                165                 170                 175     


Leu Gln Ser Ser Gly Leu Tyr Ser Leu Ser Ser Val Val Thr Val Pro 
            180                 185                 190         


Ser Ser Ser Leu Gly Thr Gln Thr Tyr Ile Cys Asn Val Asn His Lys 
        195                 200                 205             


Pro Ser Asn Thr Lys Val Asp Lys Lys Val Glu Pro Lys Ser Cys Asp 
    210                 215                 220                 


Lys Thr His Thr Cys Pro Pro Cys Pro Ala Pro Glu Leu Leu Gly Gly 
225                 230                 235                 240 


Pro Ser Val Phe Leu Phe Pro Pro Lys Pro Lys Asp Thr Leu Met Ile 
                245                 250                 255     


Ser Arg Thr Pro Glu Val Thr Cys Val Val Val Asp Val Ser His Glu 
            260                 265                 270         


Asp Pro Glu Val Lys Phe Asn Trp Tyr Val Asp Gly Val Glu Val His 
        275                 280                 285             


Asn Ala Lys Thr Lys Pro Arg Glu Glu Gln Tyr Asn Ser Thr Tyr Arg 
    290                 295                 300                 


Val Val Ser Val Leu Thr Val Leu His Gln Asp Trp Leu Asn Gly Lys 
305                 310                 315                 320 


Glu Tyr Lys Cys Lys Val Ser Asn Lys Ala Leu Pro Ala Pro Ile Glu 
                325                 330                 335     


Lys Thr Ile Ser Lys Ala Lys Gly Gln Pro Arg Glu Pro Gln Val Tyr 
            340                 345                 350         


Thr Leu Pro Pro Ser Arg Asp Glu Leu Thr Lys Asn Gln Val Ser Leu 
        355                 360                 365             


Thr Cys Leu Val Lys Gly Phe Tyr Pro Ser Asp Ile Ala Val Glu Trp 
    370                 375                 380                 


Glu Ser Asn Gly Gln Pro Glu Asn Asn Tyr Lys Thr Thr Pro Pro Val 
385                 390                 395                 400 


Leu Asp Ser Asp Gly Ser Phe Phe Leu Tyr Ser Lys Leu Thr Val Asp 
                405                 410                 415     


Lys Ser Arg Trp Gln Gln Gly Asn Val Phe Ser Cys Ser Val Met His 
            420                 425                 430         


Glu Ala Leu His Asn His Tyr Thr Gln Lys Ser Leu Ser Leu Ser Pro 
        435                 440                 445             


Gly Lys 
    450 


<210>  189
<211>  216
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic avelumab light chain

<400>  189

Gln Ser Ala Leu Thr Gln Pro Ala Ser Val Ser Gly Ser Pro Gly Gln 
1               5                   10                  15      


Ser Ile Thr Ile Ser Cys Thr Gly Thr Ser Ser Asp Val Gly Gly Tyr 
            20                  25                  30          


Asn Tyr Val Ser Trp Tyr Gln Gln His Pro Gly Lys Ala Pro Lys Leu 
        35                  40                  45              


Met Ile Tyr Asp Val Ser Asn Arg Pro Ser Gly Val Ser Asn Arg Phe 
    50                  55                  60                  


Ser Gly Ser Lys Ser Gly Asn Thr Ala Ser Leu Thr Ile Ser Gly Leu 
65                  70                  75                  80  


Gln Ala Glu Asp Glu Ala Asp Tyr Tyr Cys Ser Ser Tyr Thr Ser Ser 
                85                  90                  95      


Ser Thr Arg Val Phe Gly Thr Gly Thr Lys Val Thr Val Leu Gly Gln 
            100                 105                 110         


Pro Lys Ala Asn Pro Thr Val Thr Leu Phe Pro Pro Ser Ser Glu Glu 
        115                 120                 125             


Leu Gln Ala Asn Lys Ala Thr Leu Val Cys Leu Ile Ser Asp Phe Tyr 
    130                 135                 140                 


Pro Gly Ala Val Thr Val Ala Trp Lys Ala Asp Gly Ser Pro Val Lys 
145                 150                 155                 160 


Ala Gly Val Glu Thr Thr Lys Pro Ser Lys Gln Ser Asn Asn Lys Tyr 
                165                 170                 175     


Ala Ala Ser Ser Tyr Leu Ser Leu Thr Pro Glu Gln Trp Lys Ser His 
            180                 185                 190         


Arg Ser Tyr Ser Cys Gln Val Thr His Glu Gly Ser Thr Val Glu Lys 
        195                 200                 205             


Thr Val Ala Pro Thr Glu Cys Ser 
    210                 215     


<210>  190
<211>  120
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic avelumab variable heavy chain

<400>  190

Glu Val Gln Leu Leu Glu Ser Gly Gly Gly Leu Val Gln Pro Gly Gly 
1               5                   10                  15      


Ser Leu Arg Leu Ser Cys Ala Ala Ser Gly Phe Thr Phe Ser Ser Tyr 
            20                  25                  30          


Ile Met Met Trp Val Arg Gln Ala Pro Gly Lys Gly Leu Glu Trp Val 
        35                  40                  45              


Ser Ser Ile Tyr Pro Ser Gly Gly Ile Thr Phe Tyr Ala Asp Thr Val 
    50                  55                  60                  


Lys Gly Arg Phe Thr Ile Ser Arg Asp Asn Ser Lys Asn Thr Leu Tyr 
65                  70                  75                  80  


Leu Gln Met Asn Ser Leu Arg Ala Glu Asp Thr Ala Val Tyr Tyr Cys 
                85                  90                  95      


Ala Arg Ile Lys Leu Gly Thr Val Thr Thr Val Asp Tyr Trp Gly Gln 
            100                 105                 110         


Gly Thr Leu Val Thr Val Ser Ser 
        115                 120 


<210>  191
<211>  110
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic avelumab variable light chain

<400>  191

Gln Ser Ala Leu Thr Gln Pro Ala Ser Val Ser Gly Ser Pro Gly Gln 
1               5                   10                  15      


Ser Ile Thr Ile Ser Cys Thr Gly Thr Ser Ser Asp Val Gly Gly Tyr 
            20                  25                  30          


Asn Tyr Val Ser Trp Tyr Gln Gln His Pro Gly Lys Ala Pro Lys Leu 
        35                  40                  45              


Met Ile Tyr Asp Val Ser Asn Arg Pro Ser Gly Val Ser Asn Arg Phe 
    50                  55                  60                  


Ser Gly Ser Lys Ser Gly Asn Thr Ala Ser Leu Thr Ile Ser Gly Leu 
65                  70                  75                  80  


Gln Ala Glu Asp Glu Ala Asp Tyr Tyr Cys Ser Ser Tyr Thr Ser Ser 
                85                  90                  95      


Ser Thr Arg Val Phe Gly Thr Gly Thr Lys Val Thr Val Leu 
            100                 105                 110 


<210>  192
<211>  5
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic avelumab heavy chain CDR1

<400>  192

Ser Tyr Ile Met Met 
1               5   


<210>  193
<211>  17
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic avelumab heavy chain CDR2

<400>  193

Ser Ile Tyr Pro Ser Gly Gly Ile Thr Phe Tyr Ala Asp Thr Val Lys 
1               5                   10                  15      


Gly 
    


<210>  194
<211>  11
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic avelumab heavy chain CDR3

<400>  194

Ile Lys Leu Gly Thr Val Thr Thr Val Asp Tyr 
1               5                   10      


<210>  195
<211>  14
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic avelumab light chain CDR1

<400>  195

Thr Gly Thr Ser Ser Asp Val Gly Gly Tyr Asn Tyr Val Ser 
1               5                   10                  


<210>  196
<211>  7
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic avelumab light chain CDR2

<400>  196

Asp Val Ser Asn Arg Pro Ser 
1               5           


<210>  197
<211>  10
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic avelumab light chain CDR3

<400>  197

Ser Ser Tyr Thr Ser Ser Ser Thr Arg Val 
1               5                   10  


<210>  198
<211>  448
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic atezolizumab heavy chain

<400>  198

Glu Val Gln Leu Val Glu Ser Gly Gly Gly Leu Val Gln Pro Gly Gly 
1               5                   10                  15      


Ser Leu Arg Leu Ser Cys Ala Ala Ser Gly Phe Thr Phe Ser Asp Ser 
            20                  25                  30          


Trp Ile His Trp Val Arg Gln Ala Pro Gly Lys Gly Leu Glu Trp Val 
        35                  40                  45              


Ala Trp Ile Ser Pro Tyr Gly Gly Ser Thr Tyr Tyr Ala Asp Ser Val 
    50                  55                  60                  


Lys Gly Arg Phe Thr Ile Ser Ala Asp Thr Ser Lys Asn Thr Ala Tyr 
65                  70                  75                  80  


Leu Gln Met Asn Ser Leu Arg Ala Glu Asp Thr Ala Val Tyr Tyr Cys 
                85                  90                  95      


Ala Arg Arg His Trp Pro Gly Gly Phe Asp Tyr Trp Gly Gln Gly Thr 
            100                 105                 110         


Leu Val Thr Val Ser Ser Ala Ser Thr Lys Gly Pro Ser Val Phe Pro 
        115                 120                 125             


Leu Ala Pro Ser Ser Lys Ser Thr Ser Gly Gly Thr Ala Ala Leu Gly 
    130                 135                 140                 


Cys Leu Val Lys Asp Tyr Phe Pro Glu Pro Val Thr Val Ser Trp Asn 
145                 150                 155                 160 


Ser Gly Ala Leu Thr Ser Gly Val His Thr Phe Pro Ala Val Leu Gln 
                165                 170                 175     


Ser Ser Gly Leu Tyr Ser Leu Ser Ser Val Val Thr Val Pro Ser Ser 
            180                 185                 190         


Ser Leu Gly Thr Gln Thr Tyr Ile Cys Asn Val Asn His Lys Pro Ser 
        195                 200                 205             


Asn Thr Lys Val Asp Lys Lys Val Glu Pro Lys Ser Cys Asp Lys Thr 
    210                 215                 220                 


His Thr Cys Pro Pro Cys Pro Ala Pro Glu Leu Leu Gly Gly Pro Ser 
225                 230                 235                 240 


Val Phe Leu Phe Pro Pro Lys Pro Lys Asp Thr Leu Met Ile Ser Arg 
                245                 250                 255     


Thr Pro Glu Val Thr Cys Val Val Val Asp Val Ser His Glu Asp Pro 
            260                 265                 270         


Glu Val Lys Phe Asn Trp Tyr Val Asp Gly Val Glu Val His Asn Ala 
        275                 280                 285             


Lys Thr Lys Pro Arg Glu Glu Gln Tyr Ala Ser Thr Tyr Arg Val Val 
    290                 295                 300                 


Ser Val Leu Thr Val Leu His Gln Asp Trp Leu Asn Gly Lys Glu Tyr 
305                 310                 315                 320 


Lys Cys Lys Val Ser Asn Lys Ala Leu Pro Ala Pro Ile Glu Lys Thr 
                325                 330                 335     


Ile Ser Lys Ala Lys Gly Gln Pro Arg Glu Pro Gln Val Tyr Thr Leu 
            340                 345                 350         


Pro Pro Ser Arg Glu Glu Met Thr Lys Asn Gln Val Ser Leu Thr Cys 
        355                 360                 365             


Leu Val Lys Gly Phe Tyr Pro Ser Asp Ile Ala Val Glu Trp Glu Ser 
    370                 375                 380                 


Asn Gly Gln Pro Glu Asn Asn Tyr Lys Thr Thr Pro Pro Val Leu Asp 
385                 390                 395                 400 


Ser Asp Gly Ser Phe Phe Leu Tyr Ser Lys Leu Thr Val Asp Lys Ser 
                405                 410                 415     


Arg Trp Gln Gln Gly Asn Val Phe Ser Cys Ser Val Met His Glu Ala 
            420                 425                 430         


Leu His Asn His Tyr Thr Gln Lys Ser Leu Ser Leu Ser Pro Gly Lys 
        435                 440                 445             


<210>  199
<211>  214
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic atezolizumab light chain

<400>  199

Asp Ile Gln Met Thr Gln Ser Pro Ser Ser Leu Ser Ala Ser Val Gly 
1               5                   10                  15      


Asp Arg Val Thr Ile Thr Cys Arg Ala Ser Gln Asp Val Ser Thr Ala 
            20                  25                  30          


Val Ala Trp Tyr Gln Gln Lys Pro Gly Lys Ala Pro Lys Leu Leu Ile 
        35                  40                  45              


Tyr Ser Ala Ser Phe Leu Tyr Ser Gly Val Pro Ser Arg Phe Ser Gly 
    50                  55                  60                  


Ser Gly Ser Gly Thr Asp Phe Thr Leu Thr Ile Ser Ser Leu Gln Pro 
65                  70                  75                  80  


Glu Asp Phe Ala Thr Tyr Tyr Cys Gln Gln Tyr Leu Tyr His Pro Ala 
                85                  90                  95      


Thr Phe Gly Gln Gly Thr Lys Val Glu Ile Lys Arg Thr Val Ala Ala 
            100                 105                 110         


Pro Ser Val Phe Ile Phe Pro Pro Ser Asp Glu Gln Leu Lys Ser Gly 
        115                 120                 125             


Thr Ala Ser Val Val Cys Leu Leu Asn Asn Phe Tyr Pro Arg Glu Ala 
    130                 135                 140                 


Lys Val Gln Trp Lys Val Asp Asn Ala Leu Gln Ser Gly Asn Ser Gln 
145                 150                 155                 160 


Glu Ser Val Thr Glu Gln Asp Ser Lys Asp Ser Thr Tyr Ser Leu Ser 
                165                 170                 175     


Ser Thr Leu Thr Leu Ser Lys Ala Asp Tyr Glu Lys His Lys Val Tyr 
            180                 185                 190         


Ala Cys Glu Val Thr His Gln Gly Leu Ser Ser Pro Val Thr Lys Ser 
        195                 200                 205             


Phe Asn Arg Gly Glu Cys 
    210                 


<210>  200
<211>  118
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic atezolizumab variable heavy chain

<400>  200

Glu Val Gln Leu Val Glu Ser Gly Gly Gly Leu Val Gln Pro Gly Gly 
1               5                   10                  15      


Ser Leu Arg Leu Ser Cys Ala Ala Ser Gly Phe Thr Phe Ser Asp Ser 
            20                  25                  30          


Trp Ile His Trp Val Arg Gln Ala Pro Gly Lys Gly Leu Glu Trp Val 
        35                  40                  45              


Ala Trp Ile Ser Pro Tyr Gly Gly Ser Thr Tyr Tyr Ala Asp Ser Val 
    50                  55                  60                  


Lys Gly Arg Phe Thr Ile Ser Ala Asp Thr Ser Lys Asn Thr Ala Tyr 
65                  70                  75                  80  


Leu Gln Met Asn Ser Leu Arg Ala Glu Asp Thr Ala Val Tyr Tyr Cys 
                85                  90                  95      


Ala Arg Arg His Trp Pro Gly Gly Phe Asp Tyr Trp Gly Gln Gly Thr 
            100                 105                 110         


Leu Val Thr Val Ser Ala 
        115             


<210>  201
<211>  108
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic atezolizumab variable light chain

<400>  201

Asp Ile Gln Met Thr Gln Ser Pro Ser Ser Leu Ser Ala Ser Val Gly 
1               5                   10                  15      


Asp Arg Val Thr Ile Thr Cys Arg Ala Ser Gln Asp Val Ser Thr Ala 
            20                  25                  30          


Val Ala Trp Tyr Gln Gln Lys Pro Gly Lys Ala Pro Lys Leu Leu Ile 
        35                  40                  45              


Tyr Ser Ala Ser Phe Leu Tyr Ser Gly Val Pro Ser Arg Phe Ser Gly 
    50                  55                  60                  


Ser Gly Ser Gly Thr Asp Phe Thr Leu Thr Ile Ser Ser Leu Gln Pro 
65                  70                  75                  80  


Glu Asp Phe Ala Thr Tyr Tyr Cys Gln Gln Tyr Leu Tyr His Pro Ala 
                85                  90                  95      


Thr Phe Gly Gln Gly Thr Lys Val Glu Ile Lys Arg 
            100                 105             


<210>  202
<211>  10
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic atezolizumab heavy chain CDR1

<400>  202

Gly Phe Thr Phe Ser Asp Ser Trp Ile His 
1               5                   10  


<210>  203
<211>  18
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic atezolizumab heavy chain CDR2

<400>  203

Ala Trp Ile Ser Pro Tyr Gly Gly Ser Thr Tyr Tyr Ala Asp Ser Val 
1               5                   10                  15      


Lys Gly 
        


<210>  204
<211>  9
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic atezolizumab heavy chain CDR3

<400>  204

Arg His Trp Pro Gly Gly Phe Asp Tyr 
1               5                   


<210>  205
<211>  11
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic atezolizumab light chain CDR1

<400>  205

Arg Ala Ser Gln Asp Val Ser Thr Ala Val Ala 
1               5                   10      


<210>  206
<211>  7
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic atezolizumab light chain CDR2

<400>  206

Ser Ala Ser Phe Leu Tyr Ser 
1               5           


<210>  207
<211>  9
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic atezolizumab light chain CDR3

<400>  207

Gln Gln Tyr Leu Tyr His Pro Ala Thr 
1               5                   


<210>  208
<211>  225
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic ipilimumab heavy chain

<400>  208

Gln Val Gln Leu Val Glu Ser Gly Gly Gly Val Val Gln Pro Gly Arg 
1               5                   10                  15      


Ser Leu Arg Leu Ser Cys Ala Ala Ser Gly Phe Thr Phe Ser Ser Tyr 
            20                  25                  30          


Thr Met His Trp Val Arg Gln Ala Pro Gly Lys Gly Leu Glu Trp Val 
        35                  40                  45              


Thr Phe Ile Ser Tyr Asp Gly Asn Asn Lys Tyr Tyr Ala Asp Ser Val 
    50                  55                  60                  


Lys Gly Arg Phe Thr Ile Ser Arg Asp Asn Ser Lys Asn Thr Leu Tyr 
65                  70                  75                  80  


Leu Gln Met Asn Ser Leu Arg Ala Glu Asp Thr Ala Ile Tyr Tyr Cys 
                85                  90                  95      


Ala Arg Thr Gly Trp Leu Gly Pro Phe Asp Tyr Trp Gly Gln Gly Thr 
            100                 105                 110         


Leu Val Thr Val Ser Ser Ala Ser Thr Lys Gly Pro Ser Val Phe Pro 
        115                 120                 125             


Leu Ala Pro Ser Ser Lys Ser Thr Ser Gly Gly Thr Ala Ala Leu Gly 
    130                 135                 140                 


Cys Leu Val Lys Asp Tyr Phe Pro Glu Pro Val Thr Val Ser Trp Asn 
145                 150                 155                 160 


Ser Gly Ala Leu Thr Ser Gly Val His Thr Phe Pro Ala Val Leu Gln 
                165                 170                 175     


Ser Ser Gly Leu Tyr Ser Leu Ser Ser Val Val Thr Val Pro Ser Ser 
            180                 185                 190         


Ser Leu Gly Thr Gln Thr Tyr Ile Cys Asn Val Asn His Lys Pro Ser 
        195                 200                 205             


Asn Thr Lys Val Asp Lys Arg Val Glu Pro Lys Ser Cys Asp Lys Thr 
    210                 215                 220                 


His 
225 


<210>  209
<211>  215
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic ipilimumab light chain

<400>  209

Glu Ile Val Leu Thr Gln Ser Pro Gly Thr Leu Ser Leu Ser Pro Gly 
1               5                   10                  15      


Glu Arg Ala Thr Leu Ser Cys Arg Ala Ser Gln Ser Val Gly Ser Ser 
            20                  25                  30          


Tyr Leu Ala Trp Tyr Gln Gln Lys Pro Gly Gln Ala Pro Arg Leu Leu 
        35                  40                  45              


Ile Tyr Gly Ala Phe Ser Arg Ala Thr Gly Ile Pro Asp Arg Phe Ser 
    50                  55                  60                  


Gly Ser Gly Ser Gly Thr Asp Phe Thr Leu Thr Ile Ser Arg Leu Glu 
65                  70                  75                  80  


Pro Glu Asp Phe Ala Val Tyr Tyr Cys Gln Gln Tyr Gly Ser Ser Pro 
                85                  90                  95      


Trp Thr Phe Gly Gln Gly Thr Lys Val Glu Ile Lys Arg Thr Val Ala 
            100                 105                 110         


Ala Pro Ser Val Phe Ile Phe Pro Pro Ser Asp Glu Gln Leu Lys Ser 
        115                 120                 125             


Gly Thr Ala Ser Val Val Cys Leu Leu Asn Asn Phe Tyr Pro Arg Glu 
    130                 135                 140                 


Ala Lys Val Gln Trp Lys Val Asp Asn Ala Leu Gln Ser Gly Asn Ser 
145                 150                 155                 160 


Gln Glu Ser Val Thr Glu Gln Asp Ser Lys Asp Ser Thr Tyr Ser Leu 
                165                 170                 175     


Ser Ser Thr Leu Thr Leu Ser Lys Ala Asp Tyr Glu Lys His Lys Val 
            180                 185                 190         


Tyr Ala Cys Glu Val Thr His Gln Gly Leu Ser Ser Pro Val Thr Lys 
        195                 200                 205             


Ser Phe Asn Arg Gly Glu Cys 
    210                 215 


<210>  210
<211>  118
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic ipilimumab variable heavy chain

<400>  210

Gln Val Gln Leu Val Glu Ser Gly Gly Gly Val Val Gln Pro Gly Arg 
1               5                   10                  15      


Ser Leu Arg Leu Ser Cys Ala Ala Ser Gly Phe Thr Phe Ser Ser Tyr 
            20                  25                  30          


Thr Met His Trp Val Arg Gln Ala Pro Gly Lys Gly Leu Glu Trp Val 
        35                  40                  45              


Thr Phe Ile Ser Tyr Asp Gly Asn Asn Lys Tyr Tyr Ala Asp Ser Val 
    50                  55                  60                  


Lys Gly Arg Phe Thr Ile Ser Arg Asp Asn Ser Lys Asn Thr Leu Tyr 
65                  70                  75                  80  


Leu Gln Met Asn Ser Leu Arg Ala Glu Asp Thr Ala Ile Tyr Tyr Cys 
                85                  90                  95      


Ala Arg Thr Gly Trp Leu Gly Pro Phe Asp Tyr Trp Gly Gln Gly Thr 
            100                 105                 110         


Leu Val Thr Val Ser Ser 
        115             


<210>  211
<211>  108
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic ipilimumab variable light chain

<400>  211

Glu Ile Val Leu Thr Gln Ser Pro Gly Thr Leu Ser Leu Ser Pro Gly 
1               5                   10                  15      


Glu Arg Ala Thr Leu Ser Cys Arg Ala Ser Gln Ser Val Gly Ser Ser 
            20                  25                  30          


Tyr Leu Ala Trp Tyr Gln Gln Lys Pro Gly Gln Ala Pro Arg Leu Leu 
        35                  40                  45              


Ile Tyr Gly Ala Phe Ser Arg Ala Thr Gly Ile Pro Asp Arg Phe Ser 
    50                  55                  60                  


Gly Ser Gly Ser Gly Thr Asp Phe Thr Leu Thr Ile Ser Arg Leu Glu 
65                  70                  75                  80  


Pro Glu Asp Phe Ala Val Tyr Tyr Cys Gln Gln Tyr Gly Ser Ser Pro 
                85                  90                  95      


Trp Thr Phe Gly Gln Gly Thr Lys Val Glu Ile Lys 
            100                 105             


<210>  212
<211>  8
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic ipilimumab heavy chain CDR1

<400>  212

Gly Phe Thr Phe Ser Ser Tyr Thr 
1               5               


<210>  213
<211>  10
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic ipilimumab heavy chain CDR2

<400>  213

Thr Phe Ile Ser Tyr Asp Gly Asn Asn Lys 
1               5                   10  


<210>  214
<211>  11
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic ipilimumab heavy chain CDR3

<400>  214

Ala Arg Thr Gly Trp Leu Gly Pro Phe Asp Tyr 
1               5                   10      


<210>  215
<211>  7
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic ipilimumab light chain CDR1

<400>  215

Gln Ser Val Gly Ser Ser Tyr 
1               5           


<210>  216
<211>  3
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic ipilimumab light chain CDR2

<400>  216

Gly Ala Phe 
1           


<210>  217
<211>  9
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic ipilimumab light chain CDR3

<400>  217

Gln Gln Tyr Gly Ser Ser Pro Trp Thr 
1               5                   


<210>  218
<211>  451
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic tremelimumab heavy chain

<400>  218

Gln Val Gln Leu Val Glu Ser Gly Gly Gly Val Val Gln Pro Gly Arg 
1               5                   10                  15      


Ser Leu Arg Leu Ser Cys Ala Ala Ser Gly Phe Thr Phe Ser Ser Tyr 
            20                  25                  30          


Gly Met His Trp Val Arg Gln Ala Pro Gly Lys Gly Leu Glu Trp Val 
        35                  40                  45              


Ala Val Ile Trp Tyr Asp Gly Ser Asn Lys Tyr Tyr Ala Asp Ser Val 
    50                  55                  60                  


Lys Gly Arg Phe Thr Ile Ser Arg Asp Asn Ser Lys Asn Thr Leu Tyr 
65                  70                  75                  80  


Leu Gln Met Asn Ser Leu Arg Ala Glu Asp Thr Ala Val Tyr Tyr Cys 
                85                  90                  95      


Ala Arg Asp Pro Arg Gly Ala Thr Leu Tyr Tyr Tyr Tyr Tyr Gly Met 
            100                 105                 110         


Asp Val Trp Gly Gln Gly Thr Thr Val Thr Val Ser Ser Ala Ser Thr 
        115                 120                 125             


Lys Gly Pro Ser Val Phe Pro Leu Ala Pro Cys Ser Arg Ser Thr Ser 
    130                 135                 140                 


Glu Ser Thr Ala Ala Leu Gly Cys Leu Val Lys Asp Tyr Phe Pro Glu 
145                 150                 155                 160 


Pro Val Thr Val Ser Trp Asn Ser Gly Ala Leu Thr Ser Gly Val His 
                165                 170                 175     


Thr Phe Pro Ala Val Leu Gln Ser Ser Gly Leu Tyr Ser Leu Ser Ser 
            180                 185                 190         


Val Val Thr Val Pro Ser Ser Asn Phe Gly Thr Gln Thr Tyr Thr Cys 
        195                 200                 205             


Asn Val Asp His Lys Pro Ser Asn Thr Lys Val Asp Lys Thr Val Glu 
    210                 215                 220                 


Arg Lys Cys Cys Val Glu Cys Pro Pro Cys Pro Ala Pro Pro Val Ala 
225                 230                 235                 240 


Gly Pro Ser Val Phe Leu Phe Pro Pro Lys Pro Lys Asp Thr Leu Met 
                245                 250                 255     


Ile Ser Arg Thr Pro Glu Val Thr Cys Val Val Val Asp Val Ser His 
            260                 265                 270         


Glu Asp Pro Glu Val Gln Phe Asn Trp Tyr Val Asp Gly Val Glu Val 
        275                 280                 285             


His Asn Ala Lys Thr Lys Pro Arg Glu Glu Gln Phe Asn Ser Thr Phe 
    290                 295                 300                 


Arg Val Val Ser Val Leu Thr Val Val His Gln Asp Trp Leu Asn Gly 
305                 310                 315                 320 


Lys Glu Tyr Lys Cys Lys Val Ser Asn Lys Gly Leu Pro Ala Pro Ile 
                325                 330                 335     


Glu Lys Thr Ile Ser Lys Thr Lys Gly Gln Pro Arg Glu Pro Gln Val 
            340                 345                 350         


Tyr Thr Leu Pro Pro Ser Arg Glu Glu Met Thr Lys Asn Gln Val Ser 
        355                 360                 365             


Leu Thr Cys Leu Val Lys Gly Phe Tyr Pro Ser Asp Ile Ala Val Glu 
    370                 375                 380                 


Trp Glu Ser Asn Gly Gln Pro Glu Asn Asn Tyr Lys Thr Thr Pro Pro 
385                 390                 395                 400 


Met Leu Asp Ser Asp Gly Ser Phe Phe Leu Tyr Ser Lys Leu Thr Val 
                405                 410                 415     


Asp Lys Ser Arg Trp Gln Gln Gly Asn Val Phe Ser Cys Ser Val Met 
            420                 425                 430         


His Glu Ala Leu His Asn His Tyr Thr Gln Lys Ser Leu Ser Leu Ser 
        435                 440                 445             


Pro Gly Lys 
    450     


<210>  219
<211>  214
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic tremelimumab light chain

<400>  219

Asp Ile Gln Met Thr Gln Ser Pro Ser Ser Leu Ser Ala Ser Val Gly 
1               5                   10                  15      


Asp Arg Val Thr Ile Thr Cys Arg Ala Ser Gln Ser Ile Asn Ser Tyr 
            20                  25                  30          


Leu Asp Trp Tyr Gln Gln Lys Pro Gly Lys Ala Pro Lys Leu Leu Ile 
        35                  40                  45              


Tyr Ala Ala Ser Ser Leu Gln Ser Gly Val Pro Ser Arg Phe Ser Gly 
    50                  55                  60                  


Ser Gly Ser Gly Thr Asp Phe Thr Leu Thr Ile Ser Ser Leu Gln Pro 
65                  70                  75                  80  


Glu Asp Phe Ala Thr Tyr Tyr Cys Gln Gln Tyr Tyr Ser Thr Pro Phe 
                85                  90                  95      


Thr Phe Gly Pro Gly Thr Lys Val Glu Ile Lys Arg Thr Val Ala Ala 
            100                 105                 110         


Pro Ser Val Phe Ile Phe Pro Pro Ser Asp Glu Gln Leu Lys Ser Gly 
        115                 120                 125             


Thr Ala Ser Val Val Cys Leu Leu Asn Asn Phe Tyr Pro Arg Glu Ala 
    130                 135                 140                 


Lys Val Gln Trp Lys Val Asp Asn Ala Leu Gln Ser Gly Asn Ser Gln 
145                 150                 155                 160 


Glu Ser Val Thr Glu Gln Asp Ser Lys Asp Ser Thr Tyr Ser Leu Ser 
                165                 170                 175     


Ser Thr Leu Thr Leu Ser Lys Ala Asp Tyr Glu Lys His Lys Val Tyr 
            180                 185                 190         


Ala Cys Glu Val Thr His Gln Gly Leu Ser Ser Pro Val Thr Lys Ser 
        195                 200                 205             


Phe Asn Arg Gly Glu Cys 
    210                 


<210>  220
<211>  167
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic tremelimumab variable heavy chain

<400>  220

Gly Val Val Gln Pro Gly Arg Ser Leu Arg Leu Ser Cys Ala Ala Ser 
1               5                   10                  15      


Gly Phe Thr Phe Ser Ser Tyr Gly Met His Trp Val Arg Gln Ala Pro 
            20                  25                  30          


Gly Lys Gly Leu Glu Trp Val Ala Val Ile Trp Tyr Asp Gly Ser Asn 
        35                  40                  45              


Lys Tyr Tyr Ala Asp Ser Val Lys Gly Arg Phe Thr Ile Ser Arg Asp 
    50                  55                  60                  


Asn Ser Lys Asn Thr Leu Tyr Leu Gln Met Asn Ser Leu Arg Ala Glu 
65                  70                  75                  80  


Asp Thr Ala Val Tyr Tyr Cys Ala Arg Asp Pro Arg Gly Ala Thr Leu 
                85                  90                  95      


Tyr Tyr Tyr Tyr Tyr Gly Met Asp Val Trp Gly Gln Gly Thr Thr Val 
            100                 105                 110         


Thr Val Ser Ser Ala Ser Thr Lys Gly Pro Ser Val Phe Pro Leu Ala 
        115                 120                 125             


Pro Cys Ser Arg Ser Thr Ser Glu Ser Thr Ala Ala Leu Gly Cys Leu 
    130                 135                 140                 


Val Lys Asp Tyr Phe Pro Glu Pro Val Thr Val Ser Trp Asn Ser Gly 
145                 150                 155                 160 


Ala Leu Thr Ser Gly Val His 
                165         


<210>  221
<211>  139
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic tremelimumab variable light chain

<400>  221

Pro Ser Ser Leu Ser Ala Ser Val Gly Asp Arg Val Thr Ile Thr Cys 
1               5                   10                  15      


Arg Ala Ser Gln Ser Ile Asn Ser Tyr Leu Asp Trp Tyr Gln Gln Lys 
            20                  25                  30          


Pro Gly Lys Ala Pro Lys Leu Leu Ile Tyr Ala Ala Ser Ser Leu Gln 
        35                  40                  45              


Ser Gly Val Pro Ser Arg Phe Ser Gly Ser Gly Ser Gly Thr Asp Phe 
    50                  55                  60                  


Thr Leu Thr Ile Ser Ser Leu Gln Pro Glu Asp Phe Ala Thr Tyr Tyr 
65                  70                  75                  80  


Cys Gln Gln Tyr Tyr Ser Thr Pro Phe Thr Phe Gly Pro Gly Thr Lys 
                85                  90                  95      


Val Glu Ile Lys Arg Thr Val Ala Ala Pro Ser Val Phe Ile Phe Pro 
            100                 105                 110         


Pro Ser Asp Glu Gln Leu Lys Ser Gly Thr Ala Ser Val Val Cys Leu 
        115                 120                 125             


Leu Asn Asn Phe Tyr Pro Arg Glu Ala Lys Val 
    130                 135                 


<210>  222
<211>  10
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic tremelimumab heavy chain CDR1

<400>  222

Gly Phe Thr Phe Ser Ser Tyr Gly Met His 
1               5                   10  


<210>  223
<211>  15
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic tremelimumab heavy chain CDR2

<400>  223

Val Ile Trp Tyr Asp Gly Ser Asn Lys Tyr Tyr Ala Asp Ser Val 
1               5                   10                  15  


<210>  224
<211>  16
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic tremelimumab heavy chain CDR3

<400>  224

Asp Pro Arg Gly Ala Thr Leu Tyr Tyr Tyr Tyr Tyr Gly Met Asp Val 
1               5                   10                  15      


<210>  225
<211>  11
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic tremelimumab light chain CDR1

<400>  225

Arg Ala Ser Gln Ser Ile Asn Ser Tyr Leu Asp 
1               5                   10      


<210>  226
<211>  7
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic tremelimumab light chain CDR2

<400>  226

Ala Ala Ser Ser Leu Gln Ser 
1               5           


<210>  227
<211>  9
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic tremelimumab light chain CDR3

<400>  227

Gln Gln Tyr Tyr Ser Thr Pro Phe Thr 
1               5                   


<210>  228
<211>  448
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic zalifrelimab heavy chain

<400>  228

Glu Val Gln Leu Val Glu Ser Gly Gly Gly Leu Val Lys Pro Gly Gly 
1               5                   10                  15      


Ser Leu Arg Leu Ser Cys Ala Ala Ser Gly Phe Thr Phe Ser Ser Tyr 
            20                  25                  30          


Ser Met Asn Trp Val Arg Gln Ala Pro Gly Lys Gly Leu Glu Trp Val 
        35                  40                  45              


Ser Ser Ile Ser Ser Ser Ser Ser Tyr Ile Tyr Tyr Ala Asp Ser Val 
    50                  55                  60                  


Lys Gly Arg Phe Thr Ile Ser Arg Asp Asn Ala Lys Asn Ser Leu Tyr 
65                  70                  75                  80  


Leu Gln Met Asn Ser Leu Arg Ala Glu Asp Thr Ala Val Tyr Tyr Cys 
                85                  90                  95      


Ala Arg Val Gly Leu Met Gly Pro Phe Asp Ile Trp Gly Gln Gly Thr 
            100                 105                 110         


Met Val Thr Val Ser Ser Ala Ser Thr Lys Gly Pro Ser Val Phe Pro 
        115                 120                 125             


Leu Ala Pro Ser Ser Lys Ser Thr Ser Gly Gly Thr Ala Ala Leu Gly 
    130                 135                 140                 


Cys Leu Val Lys Asp Tyr Phe Pro Glu Pro Val Thr Val Ser Trp Asn 
145                 150                 155                 160 


Ser Gly Ala Leu Thr Ser Gly Val His Thr Phe Pro Ala Val Leu Gln 
                165                 170                 175     


Ser Ser Gly Leu Tyr Ser Leu Ser Ser Val Val Thr Val Pro Ser Ser 
            180                 185                 190         


Ser Leu Gly Thr Gln Thr Tyr Ile Cys Asn Val Asn His Lys Pro Ser 
        195                 200                 205             


Asn Thr Lys Val Asp Lys Arg Val Glu Pro Lys Ser Cys Asp Lys Thr 
    210                 215                 220                 


His Thr Cys Pro Pro Cys Pro Ala Pro Glu Leu Leu Gly Gly Pro Ser 
225                 230                 235                 240 


Val Phe Leu Phe Pro Pro Lys Pro Lys Asp Thr Leu Met Ile Ser Arg 
                245                 250                 255     


Thr Pro Glu Val Thr Cys Val Val Val Asp Val Ser His Glu Asp Pro 
            260                 265                 270         


Glu Val Lys Phe Asn Trp Tyr Val Asp Gly Val Glu Val His Asn Ala 
        275                 280                 285             


Lys Thr Lys Pro Arg Glu Glu Gln Tyr Asn Ser Thr Tyr Arg Val Val 
    290                 295                 300                 


Ser Val Leu Thr Val Leu His Gln Asp Trp Leu Asn Gly Lys Glu Tyr 
305                 310                 315                 320 


Lys Cys Lys Val Ser Asn Lys Ala Leu Pro Ala Pro Ile Glu Lys Thr 
                325                 330                 335     


Ile Ser Lys Ala Lys Gly Gln Pro Arg Glu Pro Gln Val Tyr Thr Leu 
            340                 345                 350         


Pro Pro Ser Arg Glu Glu Met Thr Lys Asn Gln Val Ser Leu Thr Cys 
        355                 360                 365             


Leu Val Lys Gly Phe Tyr Pro Ser Asp Ile Ala Val Glu Trp Glu Ser 
    370                 375                 380                 


Asn Gly Gln Pro Glu Asn Asn Tyr Lys Thr Thr Pro Pro Val Leu Asp 
385                 390                 395                 400 


Ser Asp Gly Ser Phe Phe Leu Tyr Ser Lys Leu Thr Val Asp Lys Ser 
                405                 410                 415     


Arg Trp Gln Gln Gly Asn Val Phe Ser Cys Ser Val Met His Glu Ala 
            420                 425                 430         


Leu His Asn His Tyr Thr Gln Lys Ser Leu Ser Leu Ser Pro Gly Lys 
        435                 440                 445             


<210>  229
<211>  214
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic zalifrelimab light chain

<400>  229

Glu Ile Val Leu Thr Gln Ser Pro Gly Thr Leu Ser Leu Ser Pro Gly 
1               5                   10                  15      


Glu Arg Ala Thr Leu Ser Cys Arg Ala Ser Gln Ser Val Ser Arg Tyr 
            20                  25                  30          


Leu Gly Trp Tyr Gln Gln Lys Pro Gly Gln Ala Pro Arg Leu Leu Ile 
        35                  40                  45              


Tyr Gly Ala Ser Thr Arg Ala Thr Gly Ile Pro Asp Arg Phe Ser Gly 
    50                  55                  60                  


Ser Gly Ser Gly Thr Asp Phe Thr Leu Thr Ile Thr Arg Leu Glu Pro 
65                  70                  75                  80  


Glu Asp Phe Ala Val Tyr Tyr Cys Gln Gln Tyr Gly Ser Ser Pro Trp 
                85                  90                  95      


Thr Phe Gly Gln Gly Thr Lys Val Glu Ile Lys Arg Thr Val Ala Ala 
            100                 105                 110         


Pro Ser Val Phe Ile Phe Pro Pro Ser Asp Glu Gln Leu Lys Ser Gly 
        115                 120                 125             


Thr Ala Ser Val Val Cys Leu Leu Asn Asn Phe Tyr Pro Arg Glu Ala 
    130                 135                 140                 


Lys Val Gln Trp Lys Val Asp Asn Ala Leu Gln Ser Gly Asn Ser Gln 
145                 150                 155                 160 


Glu Ser Val Thr Glu Gln Asp Ser Lys Asp Ser Thr Tyr Ser Leu Ser 
                165                 170                 175     


Ser Thr Leu Thr Leu Ser Lys Ala Asp Tyr Glu Lys His Lys Val Tyr 
            180                 185                 190         


Ala Cys Glu Val Thr His Gln Gly Leu Ser Ser Pro Val Thr Lys Ser 
        195                 200                 205             


Phe Asn Arg Gly Glu Cys 
    210                 


<210>  230
<211>  118
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic zalifrelimab variable heavy chain

<400>  230

Glu Val Gln Leu Val Glu Ser Gly Gly Gly Leu Val Lys Pro Gly Gly 
1               5                   10                  15      


Ser Leu Arg Leu Ser Cys Ala Ala Ser Gly Phe Thr Phe Ser Ser Tyr 
            20                  25                  30          


Ser Met Asn Trp Val Arg Gln Ala Pro Gly Lys Gly Leu Glu Trp Val 
        35                  40                  45              


Ser Ser Ile Ser Ser Ser Ser Ser Tyr Ile Tyr Tyr Ala Asp Ser Val 
    50                  55                  60                  


Lys Gly Arg Phe Thr Ile Ser Arg Asp Asn Ala Lys Asn Ser Leu Tyr 
65                  70                  75                  80  


Leu Gln Met Asn Ser Leu Arg Ala Glu Asp Thr Ala Val Tyr Tyr Cys 
                85                  90                  95      


Ala Arg Val Gly Leu Met Gly Pro Phe Asp Ile Trp Gly Gln Gly Thr 
            100                 105                 110         


Met Val Thr Val Ser Ser 
        115             


<210>  231
<211>  107
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic zalifrelimab variable light chain

<400>  231

Glu Ile Val Leu Thr Gln Ser Pro Gly Thr Leu Ser Leu Ser Pro Gly 
1               5                   10                  15      


Glu Arg Ala Thr Leu Ser Cys Arg Ala Ser Gln Ser Val Ser Arg Tyr 
            20                  25                  30          


Leu Gly Trp Tyr Gln Gln Lys Pro Gly Gln Ala Pro Arg Leu Leu Ile 
        35                  40                  45              


Tyr Gly Ala Ser Thr Arg Ala Thr Gly Ile Pro Asp Arg Phe Ser Gly 
    50                  55                  60                  


Ser Gly Ser Gly Thr Asp Phe Thr Leu Thr Ile Thr Arg Leu Glu Pro 
65                  70                  75                  80  


Glu Asp Phe Ala Val Tyr Tyr Cys Gln Gln Tyr Gly Ser Ser Pro Trp 
                85                  90                  95      


Thr Phe Gly Gln Gly Thr Lys Val Glu Ile Lys 
            100                 105         


<210>  232
<211>  8
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic zalifrelimab heavy chain CDR1

<400>  232

Gly Phe Thr Phe Ser Ser Tyr Ser 
1               5               


<210>  233
<211>  8
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic zalifrelimab heavy chain CDR2

<400>  233

Ile Ser Ser Ser Ser Ser Tyr Ile 
1               5               


<210>  234
<211>  11
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic zalifrelimab heavy chain CDR3

<400>  234

Ala Arg Val Gly Leu Met Gly Pro Phe Asp Ile 
1               5                   10      


<210>  235
<211>  6
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic zalifrelimab light chain CDR1

<400>  235

Gln Ser Val Ser Arg Tyr 
1               5       


<210>  236
<211>  3
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic zalifrelimab light chain CDR2

<400>  236

Gly Ala Ser 
1           


<210>  237
<211>  9
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic zalifrelimab light chain CDR3

<400>  237

Gln Gln Tyr Gly Ser Ser Pro Trp Thr 
1               5                   


<210>  238
<211>  5
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic

<400>  238

Gly Gly Gly Gly Ser 
1               5   


<210>  239
<211>  30
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic

<400>  239

Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser Gly 
1               5                   10                  15      


Gly Gly Gly Ser Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser 
            20                  25                  30  


<210>  240
<211>  20
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic

<400>  240

Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser Gly 
1               5                   10                  15      


Gly Gly Gly Ser 
            20  


<210>  241
<211>  15
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic

<400>  241

Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser 
1               5                   10                  15  


<210>  242
<211>  4
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic

<400>  242

Gly Gly Gly Ser 
1               


<210>  243
<211>  40
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic

<400>  243

Gly Gly Gly Ser Gly Gly Gly Ser Gly Gly Gly Ser Gly Gly Gly Ser 
1               5                   10                  15      


Gly Gly Gly Ser Gly Gly Gly Ser Gly Gly Gly Ser Gly Gly Gly Ser 
            20                  25                  30          


Gly Gly Gly Ser Gly Gly Gly Ser 
        35                  40  


<210>  244
<211>  170
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic

<400>  244

Met Gln Ile Pro Gln Ala Pro Trp Pro Val Val Trp Ala Val Leu Gln 
1               5                   10                  15      


Leu Gly Trp Arg Pro Gly Trp Phe Leu Asp Ser Pro Asp Arg Pro Trp 
            20                  25                  30          


Asn Pro Pro Thr Phe Ser Pro Ala Leu Leu Val Val Thr Glu Gly Asp 
        35                  40                  45              


Asn Ala Thr Phe Thr Cys Ser Phe Ser Asn Thr Ser Glu Ser Phe Val 
    50                  55                  60                  


Leu Asn Trp Tyr Arg Met Ser Pro Ser Asn Gln Thr Asp Lys Leu Ala 
65                  70                  75                  80  


Ala Phe Pro Glu Asp Arg Ser Gln Pro Gly Gln Asp Cys Arg Phe Arg 
                85                  90                  95      


Val Thr Gln Leu Pro Asn Gly Arg Asp Phe His Met Ser Val Val Arg 
            100                 105                 110         


Ala Arg Arg Asn Asp Ser Gly Thr Tyr Leu Cys Gly Ala Ile Ser Leu 
        115                 120                 125             


Ala Pro Lys Ala Gln Ile Lys Glu Ser Leu Arg Ala Glu Leu Arg Val 
    130                 135                 140                 


Thr Glu Arg Arg Ala Glu Val Pro Thr Ala His Pro Ser Pro Ser Pro 
145                 150                 155                 160 


Arg Pro Ala Gly Gln Phe Gln Thr Leu Val 
                165                 170 


<210>  245
<211>  191
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic

<400>  245

Met Gln Ile Pro Gln Ala Pro Trp Pro Val Val Trp Ala Val Leu Gln 
1               5                   10                  15      


Leu Gly Trp Arg Pro Gly Trp Phe Leu Asp Ser Pro Asp Arg Pro Trp 
            20                  25                  30          


Asn Pro Pro Thr Phe Ser Pro Ala Leu Leu Val Val Thr Glu Gly Asp 
        35                  40                  45              


Asn Ala Thr Phe Thr Cys Ser Phe Ser Asn Thr Ser Glu Ser Phe Val 
    50                  55                  60                  


Leu Asn Trp Tyr Arg Met Ser Pro Ser Asn Gln Thr Asp Lys Leu Ala 
65                  70                  75                  80  


Ala Phe Pro Glu Asp Arg Ser Gln Pro Gly Gln Asp Cys Arg Phe Arg 
                85                  90                  95      


Val Thr Gln Leu Pro Asn Gly Arg Asp Phe His Met Ser Val Val Arg 
            100                 105                 110         


Ala Arg Arg Asn Asp Ser Gly Thr Tyr Leu Cys Gly Ala Ile Ser Leu 
        115                 120                 125             


Ala Pro Lys Ala Gln Ile Lys Glu Ser Leu Arg Ala Glu Leu Arg Val 
    130                 135                 140                 


Thr Glu Arg Arg Ala Glu Val Pro Thr Ala His Pro Ser Pro Ser Pro 
145                 150                 155                 160 


Arg Pro Ala Gly Gln Phe Gln Thr Leu Val Val Gly Val Val Gly Gly 
                165                 170                 175     


Leu Leu Gly Ser Leu Val Leu Leu Val Trp Val Leu Ala Val Ile 
            180                 185                 190     


<210>  246
<211>  197
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic

<400>  246

Met Gln Ile Pro Gln Ala Pro Trp Pro Val Val Trp Ala Val Leu Gln 
1               5                   10                  15      


Leu Gly Trp Arg Pro Gly Trp Phe Leu Asp Ser Pro Asp Arg Pro Trp 
            20                  25                  30          


Asn Pro Pro Thr Phe Ser Pro Ala Leu Leu Val Val Thr Glu Gly Asp 
        35                  40                  45              


Asn Ala Thr Phe Thr Cys Ser Phe Ser Asn Thr Ser Glu Ser Phe Val 
    50                  55                  60                  


Leu Asn Trp Tyr Arg Met Ser Pro Ser Asn Gln Thr Asp Lys Leu Ala 
65                  70                  75                  80  


Ala Phe Pro Glu Asp Arg Ser Gln Pro Gly Gln Asp Cys Arg Phe Arg 
                85                  90                  95      


Val Thr Gln Leu Pro Asn Gly Arg Asp Phe His Met Ser Val Val Arg 
            100                 105                 110         


Ala Arg Arg Asn Asp Ser Gly Thr Tyr Leu Cys Gly Ala Ile Ser Leu 
        115                 120                 125             


Ala Pro Lys Ala Gln Ile Lys Glu Ser Leu Arg Ala Glu Leu Arg Val 
    130                 135                 140                 


Thr Glu Arg Arg Ala Glu Val Pro Thr Ala His Pro Ser Pro Ser Pro 
145                 150                 155                 160 


Arg Pro Ala Gly Gln Phe Gln Thr Leu Val Trp Val Leu Val Val Val 
                165                 170                 175     


Gly Gly Val Leu Ala Cys Tyr Ser Leu Leu Val Thr Val Ala Phe Ile 
            180                 185                 190         


Ile Phe Trp Val Phe 
        195         


<210>  247
<211>  629
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  PDCD1 extracellular and PDCD1 transmembrane domain

<400>  247
gctcacctcc gcctgagcag tggagaaggc ggcactctgg tggggctgct ccaggcatgc       60

agatcccaca ggcgccctgg ccagtcgtct gggcggtgct acaactgggc tggcggccag      120

gatggttctt agactcccca gacaggccct ggaacccccc caccttctcc ccagccctgc      180

tcgtggtgac cgaaggggac aacgccacct tcacctgcag cttctccaac acatcggaga      240

gcttcgtgct aaactggtac cgcatgagcc ccagcaacca gacggacaag ctggccgcct      300

tccccgagga ccgcagccag cccggccagg actgccgctt ccgtgtcaca caactgccca      360

acgggcgtga cttccacatg agcgtggtca gggcccggcg caatgacagc ggcacctacc      420

tctgtggggc catctccctg gcccccaagg cgcagatcaa agagagcctg cgggcagagc      480

tcagggtgac agagagaagg gcagaagtgc ccacagccca ccccagcccc tcacccaggc      540

cagccggcca gttccaaacc ctggtggttg gtgtcgtggg cggcctgctg ggcagcctgg      600

tgctgctagt ctgggtcctg gccgtcatc                                        629


<210>  248
<211>  647
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  PD-1 extracellular and CD28 transmembrane domain

<400>  248
gctcacctcc gcctgagcag tggagaaggc ggcactctgg tggggctgct ccaggcatgc       60

agatcccaca ggcgccctgg ccagtcgtct gggcggtgct acaactgggc tggcggccag      120

gatggttctt agactcccca gacaggccct ggaacccccc caccttctcc ccagccctgc      180

tcgtggtgac cgaaggggac aacgccacct tcacctgcag cttctccaac acatcggaga      240

gcttcgtgct aaactggtac cgcatgagcc ccagcaacca gacggacaag ctggccgcct      300

tccccgagga ccgcagccag cccggccagg actgccgctt ccgtgtcaca caactgccca      360

acgggcgtga cttccacatg agcgtggtca gggcccggcg caatgacagc ggcacctacc      420

tctgtggggc catctccctg gcccccaagg cgcagatcaa agagagcctg cgggcagagc      480

tcagggtgac agagagaagg gcagaagtgc ccacagccca ccccagcccc tcacccaggc      540

cagccggcca gttccaaacc ctggtgtttt gggtgctggt ggtggttggt ggagtcctgg      600

cttgctatag cttgctagta acagtggcct ttattatttt ctgggtg                    647


<210>  249
<211>  248
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic scFv-Fc antibody 38A1

<400>  249

Glu Val Gln Leu Val Glu Ser Gly Gly Gly Leu Val Gln Pro Gly Gly 
1               5                   10                  15      


Ser Leu Arg Leu Ser Cys Ala Ala Ser Gly Phe Thr Phe Ser Asn Tyr 
            20                  25                  30          


Ala Met Ser Trp Val Arg Gln Ala Pro Gly Lys Gly Leu Glu Trp Val 
        35                  40                  45              


Ser Thr Ile Ser Gly Ser Gly Gly Thr Thr Tyr Tyr Ala Asp Ser Val 
    50                  55                  60                  


Lys Gly Arg Phe Thr Ile Ser Arg Asp Asn Ser Lys Asn Thr Leu Tyr 
65                  70                  75                  80  


Leu Gln Met Asn Ser Leu Arg Val Glu Asp Thr Ala Val Tyr Tyr Cys 
                85                  90                  95      


Ala Lys Asp Trp Phe Arg Ser Ser Ser Pro Asp Ala Phe Asp Ile Trp 
            100                 105                 110         


Gly Gln Gly Thr Thr Val Thr Val Ser Ala Gly Gly Gly Gly Ser Gly 
        115                 120                 125             


Gly Gly Gly Ser Gly Gly Gly Gly Ser Gly Ala Pro Ser Tyr Val Leu 
    130                 135                 140                 


Thr Gln Pro Pro Ser Val Ser Val Ala Pro Gly Gln Thr Ala Arg Ile 
145                 150                 155                 160 


Thr Cys Gly Gly Asn Asn Ile Gly Arg Lys Ile Val His Trp Tyr Gln 
                165                 170                 175     


Gln Arg Pro Gly Gln Ala Pro Val Leu Val Ile Tyr Tyr Asp Thr Asp 
            180                 185                 190         


Arg Pro Ala Gly Ile Pro Glu Arg Phe Ser Gly Ser Asn Ser Gly Asn 
        195                 200                 205             


Met Ala Thr Leu Thr Ile Ser Thr Val Gly Ala Gly Asp Glu Ala Asp 
    210                 215                 220                 


Tyr Tyr Cys Gln Val Trp Asp Thr Gly Ser Asp His Val Val Phe Gly 
225                 230                 235                 240 


Gly Gly Thr Lys Leu Thr Val Leu 
                245             


<210>  250
<211>  122
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic

<400>  250

Glu Val Gln Leu Val Glu Ser Gly Gly Gly Leu Val Gln Pro Gly Gly 
1               5                   10                  15      


Ser Leu Arg Leu Ser Cys Ala Ala Ser Gly Phe Thr Phe Ser Asn Tyr 
            20                  25                  30          


Ala Met Ser Trp Val Arg Gln Ala Pro Gly Lys Gly Leu Glu Trp Val 
        35                  40                  45              


Ser Thr Ile Ser Gly Ser Gly Gly Thr Thr Tyr Tyr Ala Asp Ser Val 
    50                  55                  60                  


Lys Gly Arg Phe Thr Ile Ser Arg Asp Asn Ser Lys Asn Thr Leu Tyr 
65                  70                  75                  80  


Leu Gln Met Asn Ser Leu Arg Val Glu Asp Thr Ala Val Tyr Tyr Cys 
                85                  90                  95      


Ala Lys Asp Trp Phe Arg Ser Ser Ser Pro Asp Ala Phe Asp Ile Trp 
            100                 105                 110         


Gly Gln Gly Thr Thr Val Thr Val Ser Ala 
        115                 120         


<210>  251
<211>  108
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic

<400>  251

Ser Tyr Val Leu Thr Gln Pro Pro Ser Val Ser Val Ala Pro Gly Gln 
1               5                   10                  15      


Thr Ala Arg Ile Thr Cys Gly Gly Asn Asn Ile Gly Arg Lys Ile Val 
            20                  25                  30          


His Trp Tyr Gln Gln Arg Pro Gly Gln Ala Pro Val Leu Val Ile Tyr 
        35                  40                  45              


Tyr Asp Thr Asp Arg Pro Ala Gly Ile Pro Glu Arg Phe Ser Gly Ser 
    50                  55                  60                  


Asn Ser Gly Asn Met Ala Thr Leu Thr Ile Ser Thr Val Gly Ala Gly 
65                  70                  75                  80  


Asp Glu Ala Asp Tyr Tyr Cys Gln Val Trp Asp Thr Gly Ser Asp His 
                85                  90                  95      


Val Val Phe Gly Gly Gly Thr Lys Leu Thr Val Leu 
            100                 105             


<210>  252
<211>  8
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic 38A1 anti PD-L1 heavy chain CDR1

<400>  252

Gly Phe Thr Phe Ser Asn Tyr Ala 
1               5               


<210>  253
<211>  8
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic 38A1 anti PD-L1 heavy chain CDR2

<400>  253

Ile Ser Gly Ser Gly Gly Thr Thr 
1               5               


<210>  254
<211>  15
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic 38A1 anti PD-L1 heavy chain CDR3

<400>  254

Ala Lys Asp Trp Phe Arg Ser Ser Ser Pro Asp Ala Phe Asp Ile 
1               5                   10                  15  


<210>  255
<211>  6
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic

<400>  255

Asn Ile Gly Arg Lys Ile 
1               5       


<210>  256
<211>  3
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic

<400>  256

Tyr Asp Thr 
1           


<210>  257
<211>  11
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic

<400>  257

Gln Val Trp Asp Thr Gly Ser Asp His Val Val 
1               5                   10      


<210>  258
<211>  251
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic

<400>  258

Gln Val Gln Leu Gln Glu Ser Gly Gly Gly Leu Val Lys Pro Gly Gly 
1               5                   10                  15      


Ser Leu Arg Leu Ser Cys Ala Ala Ser Gly Phe Thr Phe Ser Ser Tyr 
            20                  25                  30          


Ser Met Asn Trp Val Arg Gln Ala Pro Gly Lys Gly Leu Glu Trp Val 
        35                  40                  45              


Ser Gly Ile Asn Thr Ala Gly Asp Thr His Tyr Pro Glu Ser Val Lys 
    50                  55                  60                  


Gly Arg Phe Thr Ile Ser Arg Asp Asn Ala Arg Asn Ser Leu Asn Leu 
65                  70                  75                  80  


Gln Met Asn Ser Leu Arg Ala Glu Asp Thr Ala Val Tyr Tyr Cys Val 
                85                  90                  95      


Arg Glu Arg Val Glu Arg Glu Tyr Ser Gly Tyr Asp Ala Phe Asp Ile 
            100                 105                 110         


Trp Gly Gln Gly Thr Thr Val Thr Val Ser Ala Gly Gly Gly Gly Ser 
        115                 120                 125             


Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser Gly Ala Pro Asn Phe Met 
    130                 135                 140                 


Leu Thr Gln Pro His Ser Val Ser Glu Ser Leu Gly Lys Thr Val Thr 
145                 150                 155                 160 


Ile Ser Cys Thr Gly Ser Ser Gly Ser Ile Ala Arg Lys Phe Val Gln 
                165                 170                 175     


Trp Tyr Gln Gln Arg Pro Gly Ser Ser Pro Thr Thr Val Ile Tyr Glu 
            180                 185                 190         


Asn Asn Gln Arg Pro Ser Gly Val Ser Asp Arg Phe Ser Gly Ser Ile 
        195                 200                 205             


Gly Ser Ser Ser Asn Ser Ala Ser Leu Thr Ile Ser Gly Leu Lys Thr 
    210                 215                 220                 


Glu Asp Glu Ala Asp Tyr Tyr Cys Gln Ser Tyr Asp Ser Ser Asn Val 
225                 230                 235                 240 


Val Phe Gly Gly Gly Thr Lys Val Thr Val Leu 
                245                 250     


<210>  259
<211>  123
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic

<400>  259

Gln Val Gln Leu Gln Glu Ser Gly Gly Gly Leu Val Lys Pro Gly Gly 
1               5                   10                  15      


Ser Leu Arg Leu Ser Cys Ala Ala Ser Gly Phe Thr Phe Ser Ser Tyr 
            20                  25                  30          


Ser Met Asn Trp Val Arg Gln Ala Pro Gly Lys Gly Leu Glu Trp Val 
        35                  40                  45              


Ser Gly Ile Asn Thr Ala Gly Asp Thr His Tyr Pro Glu Ser Val Lys 
    50                  55                  60                  


Gly Arg Phe Thr Ile Ser Arg Asp Asn Ala Arg Asn Ser Leu Asn Leu 
65                  70                  75                  80  


Gln Met Asn Ser Leu Arg Ala Glu Asp Thr Ala Val Tyr Tyr Cys Val 
                85                  90                  95      


Arg Glu Arg Val Glu Arg Glu Tyr Ser Gly Tyr Asp Ala Phe Asp Ile 
            100                 105                 110         


Trp Gly Gln Gly Thr Thr Val Thr Val Ser Ala 
        115                 120             


<210>  260
<211>  110
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic

<400>  260

Asn Phe Met Leu Thr Gln Pro His Ser Val Ser Glu Ser Leu Gly Lys 
1               5                   10                  15      


Thr Val Thr Ile Ser Cys Thr Gly Ser Ser Gly Ser Ile Ala Arg Lys 
            20                  25                  30          


Phe Val Gln Trp Tyr Gln Gln Arg Pro Gly Ser Ser Pro Thr Thr Val 
        35                  40                  45              


Ile Tyr Glu Asn Asn Gln Arg Pro Ser Gly Val Ser Asp Arg Phe Ser 
    50                  55                  60                  


Gly Ser Ile Gly Ser Ser Ser Asn Ser Ala Ser Leu Thr Ile Ser Gly 
65                  70                  75                  80  


Leu Lys Thr Glu Asp Glu Ala Asp Tyr Tyr Cys Gln Ser Tyr Asp Ser 
                85                  90                  95      


Ser Asn Val Val Phe Gly Gly Gly Thr Lys Val Thr Val Leu 
            100                 105                 110 


<210>  261
<211>  8
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic

<400>  261

Gly Phe Thr Phe Ser Ser Tyr Ser 
1               5               


<210>  262
<211>  7
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic

<400>  262

Ile Asn Thr Ala Gly Asp Thr 
1               5           


<210>  263
<211>  17
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic

<400>  263

Val Arg Glu Arg Val Glu Arg Glu Tyr Ser Gly Tyr Asp Ala Phe Asp 
1               5                   10                  15      


Ile 
    


<210>  264
<211>  8
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic

<400>  264

Ser Gly Ser Ile Ala Arg Lys Phe 
1               5               


<210>  265
<211>  3
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic

<400>  265

Glu Asn Asn 
1           


<210>  266
<211>  9
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic

<400>  266

Gln Ser Tyr Asp Ser Ser Asn Val Val 
1               5                   


<210>  267
<211>  121
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic

<400>  267

Gln Val Gln Leu Val Glu Ser Gly Gly Gly Val Val Gln Pro Gly Arg 
1               5                   10                  15      


Ser Leu Arg Leu Ser Cys Ser Ser Ser Gly Phe Ala Leu Thr Asp Tyr 
            20                  25                  30          


Tyr Met Ser Trp Val Arg Gln Ala Pro Gly Lys Gly Leu Glu Trp Leu 
        35                  40                  45              


Gly Phe Ile Ala Asn Lys Ala Asn Gly His Thr Thr Asp Tyr Ser Pro 
    50                  55                  60                  


Ser Val Lys Gly Arg Phe Thr Ile Ser Arg Asp Asn Ser Lys Asn Thr 
65                  70                  75                  80  


Leu Phe Leu Gln Met Asp Ser Leu Arg Pro Glu Asp Thr Gly Val Tyr 
                85                  90                  95      


Phe Cys Ala Arg Asp Met Gly Ile Arg Trp Asn Phe Asp Val Trp Gly 
            100                 105                 110         


Gln Gly Thr Pro Val Thr Val Ser Ser 
        115                 120     


<210>  268
<211>  107
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic

<400>  268

Asp Ile Gln Leu Thr Gln Ser Pro Ser Ser Leu Ser Ala Ser Val Gly 
1               5                   10                  15      


Asp Arg Val Thr Met Thr Cys Ser Ala Ser Ser Arg Val Ser Tyr Ile 
            20                  25                  30          


His Trp Tyr Gln Gln Lys Pro Gly Lys Ala Pro Lys Arg Trp Ile Tyr 
        35                  40                  45              


Gly Thr Ser Thr Leu Ala Ser Gly Val Pro Ala Arg Phe Ser Gly Ser 
    50                  55                  60                  


Gly Ser Gly Thr Asp Phe Thr Phe Thr Ile Ser Ser Leu Gln Pro Glu 
65                  70                  75                  80  


Asp Ile Ala Thr Tyr Tyr Cys Gln Gln Trp Ser Tyr Asn Pro Pro Thr 
                85                  90                  95      


Phe Gly Gln Gly Thr Lys Val Glu Ile Lys Arg 
            100                 105         


<210>  269
<211>  5
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic

<400>  269

Asp Tyr Tyr Met Ser 
1               5   


<210>  270
<211>  19
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic

<400>  270

Phe Ile Ala Asn Lys Ala Asn Gly His Thr Thr Asp Tyr Ser Pro Ser 
1               5                   10                  15      


Val Lys Gly 
            


<210>  271
<211>  10
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic

<400>  271

Asp Met Gly Ile Arg Trp Asn Phe Asp Val 
1               5                   10  


<210>  272
<211>  10
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic

<400>  272

Ser Ala Ser Ser Arg Val Ser Tyr Ile His 
1               5                   10  


<210>  273
<211>  7
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic

<400>  273

Gly Thr Ser Thr Leu Ala Ser 
1               5           


<210>  274
<211>  9
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic

<400>  274

Gln Gln Trp Ser Tyr Asn Pro Pro Thr 
1               5                   


<210>  275
<211>  117
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic

<400>  275

Glu Val Gln Leu Leu Glu Ser Gly Gly Gly Leu Val Gln Pro Gly Gly 
1               5                   10                  15      


Ser Leu Arg Leu Ser Cys Ala Ala Ser Gly Phe Thr Phe Ser Ser Tyr 
            20                  25                  30          


Ala Tyr Ser Trp Val Arg Gln Ala Pro Gly Lys Gly Leu Glu Trp Val 
        35                  40                  45              


Ser Ala Ile Ser Gly Ser Gly Gly Arg Thr Tyr Tyr Ala Asp Ser Val 
    50                  55                  60                  


Lys Gly Arg Phe Thr Ile Ser Arg Asp Asn Ser Lys Asn Thr Leu Tyr 
65                  70                  75                  80  


Leu Gln Met Asn Ser Leu Arg Ala Glu Asp Thr Ala Val Tyr Tyr Cys 
                85                  90                  95      


Ala Arg Leu Gly Tyr Gly Arg Val Asp Glu Trp Gly Arg Gly Thr Leu 
            100                 105                 110         


Val Thr Val Ser Ser 
        115         


<210>  276
<211>  110
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic

<400>  276

Gln Ser Val Leu Thr Gln Pro Pro Ser Ala Ser Gly Thr Pro Gly Gln 
1               5                   10                  15      


Arg Val Thr Ile Ser Cys Ser Gly Ser Leu Ser Asn Ile Gly Arg Asn 
            20                  25                  30          


Pro Val Asn Trp Tyr Gln Gln Leu Pro Gly Thr Ala Pro Lys Leu Leu 
        35                  40                  45              


Ile Tyr Leu Asp Asn Leu Arg Leu Ser Gly Val Pro Asp Arg Phe Ser 
    50                  55                  60                  


Gly Ser Lys Ser Gly Thr Ser Ala Ser Leu Ala Ile Ser Gly Leu Gln 
65                  70                  75                  80  


Ser Glu Asp Glu Ala Asp Tyr Tyr Cys Ala Thr Trp Asp Asp Ser His 
                85                  90                  95      


Pro Gly Trp Thr Phe Gly Gly Gly Thr Lys Leu Thr Val Leu 
            100                 105                 110 


<210>  277
<211>  5
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic

<400>  277

Ser Tyr Ala Tyr Ser 
1               5   


<210>  278
<211>  17
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic

<400>  278

Ala Ile Ser Gly Ser Gly Gly Arg Thr Tyr Tyr Ala Asp Ser Val Lys 
1               5                   10                  15      


Gly 
    


<210>  279
<211>  8
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic

<400>  279

Leu Gly Tyr Gly Arg Val Asp Glu 
1               5               


<210>  280
<211>  13
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic

<400>  280

Ser Gly Ser Leu Ser Asn Ile Gly Arg Asn Pro Val Asn 
1               5                   10              


<210>  281
<211>  7
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic

<400>  281

Leu Asp Asn Leu Arg Leu Ser 
1               5           


<210>  282
<211>  11
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic

<400>  282

Ala Thr Trp Asp Asp Ser His Pro Gly Trp Thr 
1               5                   10      


<210>  283
<211>  122
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic

<400>  283

Glu Val Gln Leu Val Glu Ser Gly Gly Gly Leu Val Gln Pro Gly Arg 
1               5                   10                  15      


Ser Leu Arg Leu Ser Cys Ala Ala Ser Gly Phe Thr Phe Asp Asp Tyr 
            20                  25                  30          


Ala Met His Trp Val Arg Gln Ala Pro Gly Lys Gly Leu Glu Trp Val 
        35                  40                  45              


Ser Gly Ile Ser Trp Asn Ser Gly Ser Ile Gly Tyr Ala Asp Ser Val 
    50                  55                  60                  


Lys Gly Arg Phe Thr Ile Ser Arg Asp Asn Ala Lys Asn Ser Leu Tyr 
65                  70                  75                  80  


Leu Gln Met Asn Ser Leu Arg Ala Glu Asp Thr Ala Leu Tyr Tyr Cys 
                85                  90                  95      


Val Arg Ser Gly Ser Tyr Asn Tyr Tyr Tyr Tyr Gly Met Asp Val Trp 
            100                 105                 110         


Gly Gln Gly Thr Thr Val Thr Val Ser Arg 
        115                 120         


<210>  284
<211>  111
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic

<400>  284

Gln Ser Val Leu Thr Gln Pro Pro Ser Ala Ser Gly Thr Pro Gly Gln 
1               5                   10                  15      


Arg Val Thr Ile Ser Cys Ser Gly Ser Ser Ser Asn Ile Gly Ser Asn 
            20                  25                  30          


Thr Val Asn Trp Tyr Gln Gln Leu Pro Gly Thr Ala Pro Lys Leu Leu 
        35                  40                  45              


Ile Tyr Ser Asn Asn Gln Arg Pro Ser Gly Val Pro Asp Arg Phe Ser 
    50                  55                  60                  


Gly Ser Lys Ser Gly Thr Ser Ala Ser Leu Ala Ile Ser Gly Leu Gln 
65                  70                  75                  80  


Ser Glu Asp Glu Ala Asp Tyr Tyr Cys Ala Ala Trp Asp Asp Ser Leu 
                85                  90                  95      


Asn Gly Trp Val Phe Gly Gly Gly Thr Lys Leu Thr Val Leu Gly 
            100                 105                 110     


<210>  285
<211>  5
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic

<400>  285

Asp Tyr Ala Met His 
1               5   


<210>  286
<211>  17
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic

<400>  286

Gly Ile Ser Trp Asn Ser Gly Ser Ile Gly Tyr Ala Asp Ser Val Lys 
1               5                   10                  15      


Gly 
    


<210>  287
<211>  13
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic

<400>  287

Ser Gly Ser Tyr Asn Tyr Tyr Tyr Tyr Gly Met Asp Val 
1               5                   10              


<210>  288
<211>  13
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic

<400>  288

Ser Gly Ser Ser Ser Asn Ile Gly Ser Asn Thr Val Asn 
1               5                   10              


<210>  289
<211>  7
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic

<400>  289

Ser Asn Asn Gln Arg Pro Ser 
1               5           


<210>  290
<211>  9
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic

<400>  290

Ala Ala Trp Asp Asp Ser Leu Asn Gly 
1               5                   


<210>  291
<211>  135
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic

<400>  291

Met Glu Trp Ser Gly Val Phe Ile Phe Leu Leu Ser Val Thr Ala Asp 
1               5                   10                  15      


Val His Ser Gln Val Gln Leu Gln Gln Ser Gly Pro Glu Leu Val Arg 
            20                  25                  30          


Pro Gly Thr Ser Val Arg Ile Ser Cys Lys Ala Ser Gly Tyr Thr Phe 
        35                  40                  45              


Thr Ile Tyr Trp Leu Gly Trp Val Lys Gln Arg Pro Gly His Gly Leu 
    50                  55                  60                  


Glu Trp Ile Gly Asn Ile Phe Pro Gly Ser Ala Tyr Ile Asn Tyr Asn 
65                  70                  75                  80  


Glu Lys Phe Lys Gly Lys Ala Thr Leu Thr Ala Asp Thr Ser Ser Ser 
                85                  90                  95      


Thr Ala Tyr Met Gln Leu Ser Ser Leu Thr Ser Glu Asp Ser Ala Val 
            100                 105                 110         


Tyr Phe Cys Ala Arg Glu Gly Ser Asn Ser Gly Tyr Trp Gly Gln Gly 
        115                 120                 125             


Thr Thr Leu Thr Val Ser Ser 
    130                 135 


<210>  292
<211>  116
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic

<400>  292

Gln Val Gln Leu Val Gln Ser Gly Ala Glu Val Lys Lys Pro Gly Ala 
1               5                   10                  15      


Ser Val Lys Val Ser Cys Lys Ala Ser Gly Tyr Thr Phe Thr Ile Tyr 
            20                  25                  30          


Trp Leu Gly Trp Val Arg Gln Ala Pro Gly Gln Gly Leu Glu Trp Met 
        35                  40                  45              


Gly Asn Ile Phe Pro Gly Ser Ala Tyr Ile Asn Tyr Asn Glu Lys Phe 
    50                  55                  60                  


Lys Gly Arg Val Thr Ile Thr Ala Asp Thr Ser Thr Ser Thr Ala Tyr 
65                  70                  75                  80  


Met Glu Leu Ser Ser Leu Arg Ser Glu Asp Thr Ala Val Tyr Tyr Cys 
                85                  90                  95      


Ala Arg Glu Gly Ser Asn Ser Gly Tyr Trp Gly Gln Gly Thr Leu Val 
            100                 105                 110         


Thr Val Ser Ser 
        115     


<210>  293
<211>  116
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic

<400>  293

Gln Val Gln Leu Val Gln Ser Gly Pro Glu Val Lys Lys Pro Gly Ala 
1               5                   10                  15      


Ser Val Lys Val Ser Cys Lys Ala Ser Gly Tyr Thr Phe Thr Ile Tyr 
            20                  25                  30          


Trp Leu Gly Trp Val Arg Gln Ala Pro Gly Gln Gly Leu Glu Trp Met 
        35                  40                  45              


Gly Asn Ile Phe Pro Gly Ser Ala Tyr Ile Asn Tyr Asn Glu Lys Phe 
    50                  55                  60                  


Lys Gly Lys Val Thr Ile Thr Ala Asp Thr Ser Thr Ser Thr Ala Tyr 
65                  70                  75                  80  


Met Glu Leu Ser Ser Leu Arg Ser Glu Asp Thr Ala Val Tyr Phe Cys 
                85                  90                  95      


Ala Arg Glu Gly Ser Asn Ser Gly Tyr Trp Gly Gln Gly Thr Leu Val 
            100                 105                 110         


Thr Val Ser Ser 
        115     


<210>  294
<211>  116
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic

<400>  294

Gln Val Gln Leu Val Gln Ser Gly Pro Glu Val Lys Lys Pro Gly Ala 
1               5                   10                  15      


Ser Val Lys Val Ser Cys Lys Ala Ser Gly Tyr Thr Phe Thr Ile Tyr 
            20                  25                  30          


Trp Leu Gly Trp Val Lys Gln Ala Pro Gly Gln Gly Leu Glu Trp Ile 
        35                  40                  45              


Gly Asn Ile Phe Pro Gly Ser Ala Tyr Ile Asn Tyr Asn Glu Lys Phe 
    50                  55                  60                  


Lys Gly Arg Val Thr Ile Thr Ala Asp Thr Ser Thr Ser Thr Ala Tyr 
65                  70                  75                  80  


Met Glu Leu Ser Ser Leu Arg Ser Glu Asp Thr Ala Val Tyr Phe Cys 
                85                  90                  95      


Ala Arg Glu Gly Ser Asn Ser Gly Tyr Trp Gly Gln Gly Thr Leu Val 
            100                 105                 110         


Thr Val Ser Ser 
        115     


<210>  295
<211>  116
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic

<400>  295

Gln Val Gln Leu Val Gln Ser Gly Ala Glu Val Lys Lys Pro Gly Ala 
1               5                   10                  15      


Ser Val Lys Val Ser Cys Lys Ala Ser Gly Tyr Thr Phe Thr Ile Tyr 
            20                  25                  30          


Trp Leu Gly Trp Val Lys Gln Ala Pro Gly Gln Gly Leu Glu Trp Ile 
        35                  40                  45              


Gly Asn Ile Phe Pro Gly Ser Ala Tyr Ile Asn Tyr Asn Glu Lys Phe 
    50                  55                  60                  


Lys Gly Lys Ala Thr Ile Thr Ala Asp Thr Ser Thr Ser Thr Ala Tyr 
65                  70                  75                  80  


Met Glu Leu Ser Ser Leu Arg Ser Glu Asp Thr Ala Val Tyr Phe Cys 
                85                  90                  95      


Ala Arg Glu Gly Ser Asn Ser Gly Tyr Trp Gly Gln Gly Thr Leu Val 
            100                 105                 110         


Thr Val Ser Ser 
        115     


<210>  296
<211>  116
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic

<400>  296

Gln Val Gln Leu Val Gln Ser Gly Pro Glu Val Val Lys Pro Gly Ala 
1               5                   10                  15      


Ser Val Lys Ile Ser Cys Lys Ala Ser Gly Tyr Thr Phe Thr Ile Tyr 
            20                  25                  30          


Trp Leu Gly Trp Val Lys Gln Ala Pro Gly Gln Gly Leu Glu Trp Ile 
        35                  40                  45              


Gly Asn Ile Phe Pro Gly Ser Ala Tyr Ile Asn Tyr Asn Glu Lys Phe 
    50                  55                  60                  


Lys Gly Lys Ala Thr Leu Thr Ala Asp Thr Ser Thr Ser Thr Ala Tyr 
65                  70                  75                  80  


Met Glu Leu Ser Ser Leu Arg Ser Glu Asp Thr Ala Val Tyr Phe Cys 
                85                  90                  95      


Ala Arg Glu Gly Ser Asn Ser Gly Tyr Trp Gly Gln Gly Thr Leu Leu 
            100                 105                 110         


Thr Val Ser Ser 
        115     


<210>  297
<211>  133
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic

<400>  297

Met Glu Ser Gln Thr Gln Val Leu Ile Ser Leu Leu Phe Trp Val Ser 
1               5                   10                  15      


Gly Thr Cys Gly Asp Ile Val Met Thr Gln Ser Pro Ser Ser Leu Ser 
            20                  25                  30          


Val Ser Ala Gly Glu Lys Val Thr Met Thr Cys Lys Ser Ser Gln Ser 
        35                  40                  45              


Leu Leu Asn Ser Gly Asn Gln Gln Asn Tyr Leu Ala Trp Tyr Gln Gln 
    50                  55                  60                  


Lys Pro Gly Gln Pro Pro Lys Leu Leu Ile Tyr Gly Ala Ser Thr Arg 
65                  70                  75                  80  


Glu Ser Gly Val Pro Asp Arg Phe Thr Gly Ser Gly Ser Gly Thr Asp 
                85                  90                  95      


Phe Thr Leu Thr Ile Asn Ser Val Gln Ala Glu Asp Leu Ala Val Tyr 
            100                 105                 110         


Tyr Cys Gln Ser Asp His Ile Tyr Pro Tyr Thr Phe Gly Gly Gly Thr 
        115                 120                 125             


Lys Leu Glu Ile Lys 
    130             


<210>  298
<211>  113
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic

<400>  298

Asp Ile Val Met Thr Gln Ser Pro Asp Ser Leu Ala Val Ser Leu Gly 
1               5                   10                  15      


Glu Arg Ala Thr Ile Asn Cys Lys Ser Ser Gln Ser Leu Leu Asn Ser 
            20                  25                  30          


Gly Asn Gln Gln Asn Tyr Leu Ala Trp Tyr Gln Gln Lys Pro Gly Gln 
        35                  40                  45              


Pro Pro Lys Leu Leu Ile Tyr Gly Ala Ser Thr Arg Glu Ser Gly Val 
    50                  55                  60                  


Pro Asp Arg Phe Ser Gly Ser Gly Ser Gly Thr Asp Phe Thr Leu Thr 
65                  70                  75                  80  


Ile Ser Ser Leu Gln Ala Glu Asp Val Ala Val Tyr Tyr Cys Gln Ser 
                85                  90                  95      


Asp His Ile Tyr Pro Tyr Thr Phe Gly Gln Gly Thr Lys Leu Glu Ile 
            100                 105                 110         


Lys 
    


<210>  299
<211>  113
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic

<400>  299

Asp Ile Val Met Thr Gln Ser Pro Asp Ser Leu Ala Val Ser Leu Gly 
1               5                   10                  15      


Glu Arg Val Thr Ile Asn Cys Lys Ser Ser Gln Ser Leu Leu Asn Ser 
            20                  25                  30          


Gly Asn Gln Gln Asn Tyr Leu Ala Trp Tyr Gln Gln Lys Pro Gly Gln 
        35                  40                  45              


Pro Pro Lys Leu Leu Ile Tyr Gly Ala Ser Thr Arg Glu Ser Gly Val 
    50                  55                  60                  


Pro Asp Arg Phe Ser Gly Ser Gly Ser Gly Thr Asp Phe Thr Leu Thr 
65                  70                  75                  80  


Ile Ser Ser Val Gln Ala Glu Asp Val Ala Val Tyr Tyr Cys Gln Ser 
                85                  90                  95      


Asp His Ile Tyr Pro Tyr Thr Phe Gly Gln Gly Thr Lys Leu Glu Ile 
            100                 105                 110         


Lys 
    


<210>  300
<211>  113
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic

<400>  300

Asp Ile Val Met Thr Gln Ser Pro Asp Ser Leu Ala Val Ser Ala Gly 
1               5                   10                  15      


Glu Arg Val Thr Met Asn Cys Lys Ser Ser Gln Ser Leu Leu Asn Ser 
            20                  25                  30          


Gly Asn Gln Gln Asn Tyr Leu Ala Trp Tyr Gln Gln Lys Pro Gly Gln 
        35                  40                  45              


Pro Pro Lys Leu Leu Ile Tyr Gly Ala Ser Thr Arg Glu Ser Gly Val 
    50                  55                  60                  


Pro Asp Arg Phe Ser Gly Ser Gly Ser Gly Thr Asp Phe Thr Leu Thr 
65                  70                  75                  80  


Ile Ser Ser Val Gln Ala Glu Asp Val Ala Val Tyr Tyr Cys Gln Ser 
                85                  90                  95      


Asp His Ile Tyr Pro Tyr Thr Phe Gly Gln Gly Thr Lys Leu Glu Ile 
            100                 105                 110         


Lys 
    


<210>  301
<211>  5
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic Anti TROP-2 CDR1 heavy chain

<400>  301

Ile Tyr Trp Leu Gly 
1               5   


<210>  302
<211>  16
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic Anti TROP-2 CDR2 heavy chain

<400>  302

Asn Ile Phe Pro Gly Ser Ala Tyr Ile Asn Tyr Asn Glu Lys Phe Lys 
1               5                   10                  15      


<210>  303
<211>  7
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic Anti TROP-2 CDR3 heavy chain

<400>  303

Glu Gly Ser Asn Ser Gly Tyr 
1               5           


<210>  304
<211>  16
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic Anti TROP-2 CDR1 light chain

<400>  304

Lys Ser Ser Gln Ser Leu Leu Asn Ser Gly Asn Gln Gln Asn Tyr Leu 
1               5                   10                  15      


<210>  305
<211>  7
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic Anti TROP-2 CDR2 light chain

<400>  305

Gly Ala Ser Thr Arg Glu Ser 
1               5           


<210>  306
<211>  9
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic Anti TROP-2 CDR3 light chain

<400>  306

Gln Ser Asp His Ile Tyr Pro Tyr Thr 
1               5                   


<210>  307
<211>  119
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic Anti TROP-2 m7E6 variable heavy chain

<400>  307

Gln Val Gln Leu Lys Glu Ser Gly Pro Gly Leu Val Ala Pro Ser Gln 
1               5                   10                  15      


Ser Leu Ser Ile Thr Cys Thr Val Ser Gly Phe Ser Leu Thr Ser Tyr 
            20                  25                  30          


Gly Val His Trp Val Arg Gln Pro Pro Gly Lys Gly Leu Glu Trp Leu 
        35                  40                  45              


Gly Val Ile Trp Thr Gly Gly Ser Thr Asp Tyr Asn Ser Ala Leu Met 
    50                  55                  60                  


Ser Arg Leu Ser Ile Asn Lys Asp Asn Ser Lys Ser Gln Val Phe Leu 
65                  70                  75                  80  


Lys Met Asn Ser Leu Gln Thr Asp Asp Thr Ala Met Tyr Tyr Cys Ala 
                85                  90                  95      


Arg Asp Gly Asp Tyr Asp Arg Tyr Thr Met Asp Tyr Trp Gly Gln Gly 
            100                 105                 110         


Thr Ser Val Thr Val Ser Ser 
        115                 


<210>  308
<211>  111
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic Anti TROP-2 m7E6 variable light chain

<400>  308

Asp Ile Val Leu Thr Gln Ser Pro Ala Ser Leu Ala Val Ser Leu Gly 
1               5                   10                  15      


Gln Arg Ala Thr Ile Ser Cys Arg Ala Ser Lys Ser Val Ser Thr Ser 
            20                  25                  30          


Gly Tyr Ser Tyr Met His Trp Tyr Gln Gln Lys Pro Gly Gln Pro Pro 
        35                  40                  45              


Lys Leu Leu Ile Tyr Leu Ala Ser Asn Leu Glu Ser Gly Val Pro Ala 
    50                  55                  60                  


Arg Phe Ser Gly Ser Gly Ser Gly Thr Asp Phe Thr Leu Asn Ile His 
65                  70                  75                  80  


Pro Val Glu Glu Glu Asp Ala Ala Thr Tyr Tyr Cys Gln His Ser Arg 
                85                  90                  95      


Glu Leu Pro Tyr Thr Phe Gly Gly Gly Thr Lys Leu Glu Ile Lys 
            100                 105                 110     


<210>  309
<211>  119
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic Anti TROP-2 h7E6 variable heavy chain

<400>  309

Gln Val Gln Leu Gln Glu Ser Gly Pro Gly Leu Val Lys Pro Ser Glu 
1               5                   10                  15      


Thr Leu Ser Leu Thr Cys Thr Val Ser Gly Gly Ser Ile Ser Ser Tyr 
            20                  25                  30          


Gly Val His Trp Ile Arg Gln Pro Pro Gly Lys Gly Leu Glu Trp Ile 
        35                  40                  45              


Gly Val Ile Trp Thr Gly Gly Ser Thr Asp Tyr Asn Ser Ala Leu Met 
    50                  55                  60                  


Ser Arg Val Thr Ile Ser Val Asp Thr Ser Lys Asn Gln Phe Ser Leu 
65                  70                  75                  80  


Lys Leu Ser Ser Val Thr Ala Ala Asp Thr Ala Val Tyr Tyr Cys Ala 
                85                  90                  95      


Arg Asp Gly Asp Tyr Asp Arg Tyr Thr Met Asp Tyr Trp Gly Gln Gly 
            100                 105                 110         


Thr Leu Val Thr Val Ser Ser 
        115                 


<210>  310
<211>  111
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic Anti TROP-2 h7E6 variable light chain

<400>  310

Asp Ile Val Met Thr Gln Ser Pro Asp Ser Leu Ala Val Ser Leu Gly 
1               5                   10                  15      


Glu Arg Ala Thr Ile Asn Cys Arg Ala Ser Lys Ser Val Ser Thr Ser 
            20                  25                  30          


Gly Tyr Ser Tyr Met His Trp Tyr Gln Gln Lys Pro Gly Gln Pro Pro 
        35                  40                  45              


Lys Leu Leu Ile Tyr Leu Ala Ser Asn Leu Glu Ser Gly Val Pro Asp 
    50                  55                  60                  


Arg Phe Ser Gly Ser Gly Ser Gly Thr Asp Phe Thr Leu Thr Ile Ser 
65                  70                  75                  80  


Ser Leu Gln Ala Glu Asp Val Ala Val Tyr Tyr Cys Gln His Ser Arg 
                85                  90                  95      


Glu Leu Pro Tyr Thr Phe Gly Gln Gly Thr Lys Leu Glu Ile Lys 
            100                 105                 110     


<210>  311
<211>  119
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic Anti TROP-2 h7E6_SVGL variable heavy chain

<400>  311

Gln Val Gln Leu Gln Glu Ser Gly Pro Gly Leu Val Lys Pro Ser Glu 
1               5                   10                  15      


Thr Leu Ser Leu Thr Cys Thr Val Ser Gly Gly Ser Ile Ser Ser Tyr 
            20                  25                  30          


Gly Val His Trp Ile Arg Gln Pro Pro Gly Lys Gly Leu Glu Trp Ile 
        35                  40                  45              


Gly Val Ile Trp Thr Ser Gly Val Thr Asp Tyr Asn Ser Ala Leu Met 
    50                  55                  60                  


Gly Arg Val Thr Ile Ser Val Asp Thr Ser Lys Asn Gln Phe Ser Leu 
65                  70                  75                  80  


Lys Leu Ser Ser Val Thr Ala Ala Asp Thr Ala Val Tyr Tyr Cys Ala 
                85                  90                  95      


Arg Asp Gly Asp Tyr Asp Arg Tyr Thr Met Asp Tyr Trp Gly Gln Gly 
            100                 105                 110         


Thr Leu Val Thr Val Ser Ser 
        115                 


<210>  312
<211>  111
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic Anti TROP-2 h7E6_SVGL variable light chain

<400>  312

Asp Ile Val Met Thr Gln Ser Pro Asp Ser Leu Ala Val Ser Leu Gly 
1               5                   10                  15      


Glu Arg Ala Thr Ile Asn Cys Arg Ala Ser Lys Ser Val Ser Thr Ser 
            20                  25                  30          


Leu Tyr Ser Tyr Met His Trp Tyr Gln Gln Lys Pro Gly Gln Pro Pro 
        35                  40                  45              


Lys Leu Leu Ile Tyr Leu Ala Ser Asn Leu Glu Ser Gly Val Pro Asp 
    50                  55                  60                  


Arg Phe Ser Gly Ser Gly Ser Gly Thr Asp Phe Thr Leu Thr Ile Ser 
65                  70                  75                  80  


Ser Leu Gln Ala Glu Asp Val Ala Val Tyr Tyr Cys Gln His Ser Arg 
                85                  90                  95      


Glu Leu Pro Tyr Thr Phe Gly Gln Gly Thr Lys Leu Glu Ile Lys 
            100                 105                 110     


<210>  313
<211>  115
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic Anti TROP-2 m6G11 variable heavy chain

<400>  313

Gln Val Gln Leu Gln Gln Pro Gly Ala Glu Leu Val Arg Pro Gly Ala 
1               5                   10                  15      


Ser Val Lys Leu Ser Cys Lys Ala Ser Gly Tyr Thr Phe Thr Ser Tyr 
            20                  25                  30          


Trp Ile Asn Trp Val Lys Gln Arg Pro Gly His Gly Leu Glu Trp Ile 
        35                  40                  45              


Gly Asn Ile Tyr Pro Ser Asp Ser Tyr Ser Asn Tyr Asn Gln Lys Phe 
    50                  55                  60                  


Lys Asp Lys Ala Thr Leu Thr Val Asp Lys Ser Ser Ser Thr Ala Tyr 
65                  70                  75                  80  


Met Gln Val Ser Ser Pro Thr Ser Glu Asp Ser Ala Val Tyr Tyr Cys 
                85                  90                  95      


Thr Tyr Gly Ser Ser Phe Asp Tyr Trp Gly Gln Gly Thr Thr Val Thr 
            100                 105                 110         


Val Ser Ser 
        115 


<210>  314
<211>  107
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic Anti TROP-2 m6G11 variable light chain

<400>  314

Asp Ile Leu Leu Thr Gln Ser Pro Ala Ile Leu Ser Val Ser Pro Gly 
1               5                   10                  15      


Glu Arg Val Ser Phe Ser Cys Arg Ala Ser Gln Thr Ile Gly Thr Ser 
            20                  25                  30          


Ile His Trp Tyr Gln Gln Arg Thr Asn Gly Ser Pro Arg Leu Leu Ile 
        35                  40                  45              


Lys Tyr Ala Ser Glu Ser Ile Ser Gly Ile Pro Ser Arg Phe Ser Gly 
    50                  55                  60                  


Ser Gly Ser Gly Thr Asp Phe Thr Leu Ser Ile Asn Ser Val Glu Ser 
65                  70                  75                  80  


Glu Asp Ile Ala Asp Tyr Tyr Cys Gln Gln Ser Asn Ser Trp Pro Phe 
                85                  90                  95      


Thr Phe Gly Ser Gly Thr Lys Leu Glu Ile Lys 
            100                 105         


<210>  315
<211>  115
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic Anti TROP-2 h6G11 variable heavy chain

<400>  315

Gln Val Gln Leu Val Gln Ser Gly Ala Glu Val Lys Lys Pro Gly Ala 
1               5                   10                  15      


Ser Val Lys Val Ser Cys Lys Ala Ser Gly Tyr Thr Phe Thr Ser Tyr 
            20                  25                  30          


Trp Ile Asn Trp Val Arg Gln Ala Pro Gly Gln Gly Leu Glu Trp Met 
        35                  40                  45              


Gly Asn Ile Tyr Pro Ser Asp Ser Tyr Ser Asn Tyr Asn Gln Lys Phe 
    50                  55                  60                  


Lys Asp Arg Val Thr Met Thr Arg Asp Thr Ser Thr Ser Thr Val Tyr 
65                  70                  75                  80  


Met Glu Leu Ser Ser Leu Arg Ser Glu Asp Thr Ala Val Tyr Tyr Cys 
                85                  90                  95      


Ala Arg Gly Ser Ser Phe Asp Tyr Trp Gly Gln Gly Thr Leu Val Thr 
            100                 105                 110         


Val Ser Ser 
        115 


<210>  316
<211>  107
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic Anti TROP-2 h6G11 variable light chain

<400>  316

Glu Ile Val Leu Thr Gln Ser Pro Ala Thr Leu Ser Leu Ser Pro Gly 
1               5                   10                  15      


Glu Arg Ala Thr Leu Ser Cys Arg Ala Ser Gln Thr Ile Gly Thr Ser 
            20                  25                  30          


Ile His Trp Tyr Gln Gln Lys Pro Gly Gln Ala Pro Arg Leu Leu Ile 
        35                  40                  45              


Tyr Tyr Ala Ser Glu Ser Ile Ser Gly Ile Pro Ala Arg Phe Ser Gly 
    50                  55                  60                  


Ser Gly Ser Gly Thr Asp Phe Thr Leu Thr Ile Ser Ser Leu Glu Pro 
65                  70                  75                  80  


Glu Asp Phe Ala Val Tyr Tyr Cys Gln Gln Ser Asn Ser Trp Pro Phe 
                85                  90                  95      


Thr Phe Gly Gln Gly Thr Lys Leu Glu Ile Lys 
            100                 105         


<210>  317
<211>  115
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic Anti TROP-2 h6G11-FKG_SF variable heavy chain

<400>  317

Gln Val Gln Leu Val Gln Ser Gly Ala Glu Val Lys Lys Pro Gly Ala 
1               5                   10                  15      


Ser Val Lys Val Ser Cys Lys Ala Ser Gly Tyr Thr Phe Thr Ser Tyr 
            20                  25                  30          


Trp Ile Asn Trp Val Arg Gln Ala Pro Gly Gln Gly Leu Glu Trp Met 
        35                  40                  45              


Gly Asn Ile Phe Pro Ser Asp Ser Tyr Ser Asn Tyr Asn Lys Lys Phe 
    50                  55                  60                  


Lys Asp Arg Val Thr Met Thr Arg Asp Thr Ser Thr Ser Thr Val Tyr 
65                  70                  75                  80  


Met Glu Leu Ser Ser Leu Arg Ser Glu Asp Thr Ala Val Tyr Tyr Cys 
                85                  90                  95      


Ala Arg Gly Ser Gly Phe Asp Tyr Trp Gly Gln Gly Thr Leu Val Thr 
            100                 105                 110         


Val Ser Ser 
        115 


<210>  318
<211>  107
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic Anti TROP-2 h6G11-FKG_SF variable light chain

<400>  318

Glu Ile Val Leu Thr Gln Ser Pro Ala Thr Leu Ser Leu Ser Pro Gly 
1               5                   10                  15      


Glu Arg Ala Thr Leu Ser Cys Arg Ala Ser Gln Thr Ile Gly Thr Ser 
            20                  25                  30          


Ile His Trp Tyr Gln Gln Lys Pro Gly Gln Ala Pro Arg Leu Leu Ile 
        35                  40                  45              


Tyr Tyr Ala Ser Glu Ser Ile Ser Gly Ile Pro Ala Arg Phe Ser Gly 
    50                  55                  60                  


Ser Gly Ser Gly Thr Asp Phe Thr Leu Thr Ile Ser Ser Leu Glu Pro 
65                  70                  75                  80  


Glu Asp Phe Ala Val Tyr Tyr Cys Ser Gln Ser Phe Ser Trp Pro Phe 
                85                  90                  95      


Thr Phe Gly Gln Gly Thr Lys Leu Glu Ile Lys 
            100                 105         


<210>  319
<211>  5
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic Anti TROP-2 CDR1 heavy chain

<400>  319

Ser Tyr Gly Val His 
1               5   


<210>  320
<211>  5
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic Anti TROP-2 CDR2 heavy chain

<400>  320

Trp Thr Ser Gly Val 
1               5   


<210>  321
<211>  11
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic Anti TROP-2 CDR3 heavy chain

<400>  321

Asp Gly Asp Tyr Asp Arg Tyr Thr Met Asp Tyr 
1               5                   10      


<210>  322
<211>  15
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic Anti TROP-2 CDR1 light chain

<400>  322

Arg Ala Ser Lys Ser Val Ser Thr Ser Gly Tyr Ser Tyr Met His 
1               5                   10                  15  


<210>  323
<211>  7
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic Anti TROP-2 CDR2 light chain

<400>  323

Leu Ala Ser Asn Leu Glu Ser 
1               5           


<210>  324
<211>  9
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic Anti TROP-2 CDR3 light chain

<400>  324

Gln His Ser Arg Glu Leu Pro Tyr Thr 
1               5                   


<210>  325
<211>  357
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Synthetic Anti TROP-2 m7E6 variable heavy chain

<400>  325
caggtccaac tgcaggaatc aggtccaggc ctggtgaaac cgtctgaaac cctgagcctg       60

acatgcaccg tgagcggtgg tagtattagc tcttacggcg tccattggat ccgtcaaccg      120

cctggtaaag gtctggaatg gattggcgtg atctggaccg gtggtagcac cgactataac      180

agcgcactga tgagccgcgt gaccatctcg gtagacacgt cgaaaaacca gttcagcctg      240

aaactgagca gcgtgaccgc cgcggatacc gctgtttatt actgcgcacg cgacggggat      300

tatgatcgct acaccatgga ttattggggc cagggtaccc tggtcaccgt ctcctca         357


<210>  326
<211>  333
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Synthetic Anti TROP-2 m7E6 variable light chain

<400>  326
gacattgtgc tgacacagtc tcctgcttcc ttagctgtat ctctggggca gagggccacc       60

atctcatgca gggccagcaa aagtgtcagt acatctggct atagttatat gcactggtac      120

caacagaaac caggacagcc acccaaactc ctcatctatc ttgcatccaa cctagaatct      180

ggggtccctg ccaggttcag tggcagtggg tctgggacag acttcaccct caacatccat      240

cctgtggagg aggaggatgc tgcaacctat tactgtcagc acagtaggga gcttccgtac      300

acgttcggag gggggaccaa gctggagatc aaa                                   333


<210>  327
<211>  357
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Synthetic Anti TROP-2 h7E6 variable heavy chain

<400>  327
caggtccaac tgcaggaatc aggtccaggc ctggtgaaac cgtctgaaac cctgagcctg       60

acatgcaccg tgagcggtgg tagtattagc tcttacggcg tccattggat ccgtcaaccg      120

cctggtaaag gtctggaatg gattggcgtg atctggaccg gtggtagcac cgactataac      180

agcgcactga tgagccgcgt gaccatctcg gtagacacgt cgaaaaacca gttcagcctg      240

aaactgagca gcgtgaccgc cgcggatacc gctgtttatt actgcgcacg cgacggggat      300

tatgatcgct acaccatgga ttattggggc cagggtaccc tggtcaccgt ctcctca         357


<210>  328
<211>  333
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Synthetic Anti TROP-2 h7E6 variable light chain

<400>  328
gatatcgtaa tgacccaatc tccggattcg ctggcggtat cactgggcga acgtgccacg       60

attaactgcc gtgcaagcaa atcagtgtcg acctccggct acagctatat gcactggtat      120

caacagaaac cgggccagcc gccgaaactg ctgatctatc tggctagcaa cctggagagc      180

ggtgtgcctg atcgctttag tggctccggt agcggtaccg atttcacgct gaccatcagc      240

tccctgcagg cagaagacgt ggccgtgtat tattgtcagc acagccgtga gctgccgtat      300

acttttggcc aggggacaaa actggaaatc aaa                                   333


<210>  329
<211>  357
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Synthetic Anti TROP-2 h7E6_SVGL variable heavy chain

<400>  329
caggtccaac tgcaggaatc aggtccaggc ctggtgaaac cgtctgaaac cctgagcctg       60

acatgcaccg tgagcggtgg tagtattagc tcttacggcg tccattggat ccgtcaaccg      120

cctggtaaag gtctggaatg gattggcgtg atctggacca gtggtgtgac cgactataac      180

agcgcactga tgggccgcgt gaccatctcg gtagacacgt cgaaaaacca gttcagcctg      240

aaactgagca gcgtgaccgc cgcggatacc gctgtttatt actgcgcacg cgacggggat      300

tatgatcgct acaccatgga ttattggggc cagggtaccc tggtcaccgt ctcctca         357


<210>  330
<211>  333
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Synthetic Anti TROP-2 h7E6_SVGL variable light chain

<400>  330
gatatcgtaa tgacccaatc tccggattcg ctggcggtat cactgggcga acgtgccacg       60

attaactgcc gtgcaagcaa atcagtgtcg acctccttgt acagctatat gcactggtat      120

caacagaaac cgggccagcc gccgaaactg ctgatctatc tggctagcaa cctggagagc      180

ggtgtgcctg atcgctttag tggctccggt agcggtaccg atttcacgct gaccatcagc      240

tccctgcagg cagaagacgt ggccgtgtat tattgtcagc acagccgtga gctgccgtat      300

acttttggcc aggggacaaa actggaaatc aaa                                   333


<210>  331
<211>  345
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Synthetic Anti TROP-2 m6G11 variable heavy chain

<400>  331
caggtccaac tgcagcagcc tggggctgag ctggtgaggc ctggggcttc agtgaagctg       60

tcctgcaagg cttctggcta caccttcacc agctactgga taaactgggt gaagcagagg      120

cctggacatg gccttgagtg gatcggaaat atttatcctt ctgatagtta ttctaactac      180

aatcaaaagt tcaaggacaa ggccacattg actgtagaca aatcctccag cacagcctac      240

atgcaggtca gcagcccgac atctgaggac tctgcggtct attactgtac gtacggtagt      300

agctttgact actggggcca aggcaccacg gtcaccgtct cctca                      345


<210>  332
<211>  321
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Synthetic Anti TROP-2 m6G11 variable light chain

<400>  332
gacatcttgc tgactcagtc tccagccatc ctgtctgtga gtccaggaga aagagtcagt       60

ttctcctgca gggccagtca gaccattggc acaagcatac actggtatca gcaaagaaca      120

aatggttctc caaggcttct cataaagtat gcttctgagt ctatctctgg gatcccttcc      180

aggtttagtg gcagtggatc agggacagat tttactctta gcatcaacag tgtggagtct      240

gaagatattg cagattatta ctgtcaacaa agtaatagct ggccattcac gttcggctcg      300

gggaccaagc tggaaataaa a                                                321


<210>  333
<211>  345
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Synthetic Anti TROP-2 h6G11 variable heavy chain

<400>  333
caggtgcagt tggttcagag cggcgcggaa gtcaagaaac ccggcgcctc cgtgaaagtg       60

agctgcaaag cgagcggcta caccttcacc agttattgga ttaactgggt gcgccaggcc      120

ccaggccagg ggctggagtg gatgggaaac atctacccat ctgactctta cagcaactat      180

aatcagaaat ttaaggatcg cgtaacaatg acccgtgaca ccagcaccag cactgtttac      240

atggagctga gttctctgcg ttctgaagat accgccgtgt actactgcgc acgcggttcc      300

agtttcgatt actggggcca ggggaccctg gtcaccgtct cctca                      345


<210>  334
<211>  321
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Synthetic Anti TROP-2 h6G11 variable light chain

<400>  334
gagatcgtgc tgacccaaag tccagccacc ctttccctgt ctccaggcga acgcgcaacc       60

ctgagctgcc gcgcttctca gaccattggt acctccattc attggtatca gcagaagccc      120

ggccaagccc cgcgtctgct gatctattac gcctcagaaa gtatttcagg catccccgct      180

cgcttctccg gctccggcag cggaaccgac ttcacactta caatctctag tttggagcca      240

gaagacttcg ccgtttacta ctgtcagcag tctaacagct ggccatttac ctttggccag      300

ggcacgaagc tggaaatcaa g                                                321


<210>  335
<211>  345
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Synthetic Anti TROP-2 h6G11-FKG_SF variable heavy chain

<400>  335
caggtgcagt tggttcagag cggcgcggaa gtcaagaaac ccggcgcctc cgtgaaagtg       60

agctgcaaag cgagcggcta caccttcacc agttattgga ttaactgggt gcgccaggcc      120

ccaggccagg ggctggagtg gatgggaaac atcttcccat ctgactctta cagcaactat      180

aataagaaat ttaaggatcg cgtaacaatg acccgtgaca ccagcaccag cactgtttac      240

atggagctga gttctctgcg ttctgaagat accgccgtgt actactgcgc acgcggttcc      300

gggttcgatt actggggcca ggggaccctg gtcaccgtct cctca                      345


<210>  336
<211>  321
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Synthetic Anti TROP-2 h6G11-FKG_SF variable light chain

<400>  336
gagatcgtgc tgacccaaag tccagccacc ctttccctgt ctccaggcga acgcgcaacc       60

ctgagctgcc gcgcttctca gaccattggt acctccattc attggtatca gcagaagccc      120

ggccaagccc cgcgtctgct gatctattac gcctcagaaa gtatttcagg catccccgct      180

cgcttctccg gctccggcag cggaaccgac ttcacactta caatctctag tttggagcca      240

gaagacttcg ccgtttacta ctgttcgcag tcttttagct ggccatttac ctttggccag      300

ggcacgaagc tggaaatcaa g                                                321


<210>  337
<211>  120
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic Anti TROP-2 sacituzumab variable heavy chain

<400>  337

Gln Val Gln Leu Gln Gln Ser Gly Ser Glu Leu Lys Lys Pro Gly Ala 
1               5                   10                  15      


Ser Val Lys Val Ser Cys Lys Ala Ser Gly Tyr Thr Phe Thr Asn Tyr 
            20                  25                  30          


Gly Met Asn Trp Val Lys Gln Ala Pro Gly Gln Gly Leu Lys Trp Met 
        35                  40                  45              


Gly Trp Ile Asn Thr Tyr Thr Gly Glu Pro Thr Tyr Thr Asp Asp Phe 
    50                  55                  60                  


Lys Gly Arg Phe Ala Phe Ser Leu Asp Thr Ser Val Ser Thr Ala Tyr 
65                  70                  75                  80  


Leu Gln Ile Ser Ser Leu Lys Ala Asp Asp Thr Ala Val Tyr Phe Cys 
                85                  90                  95      


Ala Arg Gly Gly Phe Gly Ser Ser Tyr Trp Tyr Phe Asp Val Trp Gly 
            100                 105                 110         


Gln Gly Ser Leu Val Thr Val Ser 
        115                 120 


<210>  338
<211>  107
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic Anti TROP-2 sacituzumab variable light chain

<400>  338

Asp Ile Gln Leu Thr Gln Ser Pro Ser Ser Leu Ser Ala Ser Val Gly 
1               5                   10                  15      


Asp Arg Val Ser Ile Thr Cys Lys Ala Ser Gln Asp Val Ser Ile Ala 
            20                  25                  30          


Val Ala Trp Tyr Gln Gln Lys Pro Gly Lys Ala Pro Lys Leu Leu Ile 
        35                  40                  45              


Tyr Ser Ala Ser Tyr Arg Tyr Thr Gly Val Pro Asp Arg Phe Ser Gly 
    50                  55                  60                  


Ser Gly Ser Gly Thr Asp Phe Thr Leu Thr Ile Ser Ser Leu Gln Pro 
65                  70                  75                  80  


Glu Asp Phe Ala Val Tyr Tyr Cys Gln Gln His Tyr Ile Thr Pro Leu 
                85                  90                  95      


Thr Phe Gly Ala Gly Thr Lys Val Glu Ile Lys 
            100                 105         


<210>  339
<211>  5
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic Anti TROP-2 sacituzumab CDR1 heavy chain

<400>  339

Asn Tyr Gly Met Asn 
1               5   


<210>  340
<211>  17
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic Anti TROP-2 sacituzumab CDR2 heavy chain

<400>  340

Trp Ile Asn Thr Tyr Thr Gly Glu Pro Thr Tyr Thr Asp Asp Phe Lys 
1               5                   10                  15      


Gly 
    


<210>  341
<211>  12
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic Anti TROP-2 sacituzumab CDR3 heavy chain

<400>  341

Gly Gly Phe Gly Ser Ser Tyr Trp Tyr Phe Asp Val 
1               5                   10          


<210>  342
<211>  11
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic Anti TROP-2 sacituzumab CDR1 light chain

<400>  342

Lys Ala Ser Gln Asp Val Ser Ile Ala Val Ala 
1               5                   10      


<210>  343
<211>  7
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic Anti TROP-2 sacituzumab CDR2 light chain

<400>  343

Ser Ala Ser Tyr Arg Tyr Thr 
1               5           


<210>  344
<211>  9
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic Anti TROP-2 sacituzumab CDR3 light chain

<400>  344

Gln Gln His Tyr Ile Thr Pro Leu Thr 
1               5                   


<210>  345
<211>  245
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic Anti EPCAM 3-17I scFv

<400>  345

Gln Val Gln Leu Val Gln Ser Gly Ala Glu Val Lys Lys Pro Gly Ser 
1               5                   10                  15      


Ser Val Lys Val Ser Cys Lys Ala Ser Gly Gly Thr Phe Ser Ser Tyr 
            20                  25                  30          


Ala Ile Ser Trp Val Arg Gln Ala Pro Gly Gln Gly Leu Glu Trp Met 
        35                  40                  45              


Gly Gly Ile Ile Pro Ile Phe Gly Thr Ala Asn Tyr Ala Gln Lys Phe 
    50                  55                  60                  


Gln Gly Arg Val Thr Ile Thr Ala Asp Glu Ser Thr Ser Thr Ala Tyr 
65                  70                  75                  80  


Met Glu Leu Ser Ser Leu Arg Ser Glu Asp Thr Ala Val Tyr Tyr Cys 
                85                  90                  95      


Ala Arg Gly Leu Leu Trp Asn Tyr Trp Gly Gln Gly Thr Leu Val Thr 
            100                 105                 110         


Val Ser Ser Lys Leu Ser Gly Ser Ala Ser Ala Pro Lys Leu Glu Glu 
        115                 120                 125             


Gly Glu Phe Ser Glu Ala Arg Val Glu Ile Val Met Thr Gln Ser Pro 
    130                 135                 140                 


Ala Thr Leu Ser Val Ser Pro Gly Glu Arg Ala Thr Leu Ser Cys Arg 
145                 150                 155                 160 


Ala Ser Gln Ser Val Ser Ser Asn Leu Ala Trp Tyr Gln Gln Lys Pro 
                165                 170                 175     


Gly Gln Ala Pro Arg Leu Ile Ile Tyr Gly Ala Ser Thr Thr Ala Ser 
            180                 185                 190         


Gly Ile Pro Ala Arg Phe Ser Ala Ser Gly Ser Gly Thr Asp Phe Thr 
        195                 200                 205             


Leu Thr Ile Ser Ser Leu Gln Ser Glu Asp Phe Ala Val Tyr Tyr Cys 
    210                 215                 220                 


Gln Gln Tyr Asn Asn Trp Pro Pro Ala Tyr Thr Phe Gly Gln Gly Thr 
225                 230                 235                 240 


Lys Leu Glu Ile Lys 
                245 


<210>  346
<211>  245
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic Anti EPCAM 7-F17 scFv

<400>  346

Gln Val Gln Leu Val Gln Ser Gly Ala Glu Val Lys Lys Pro Gly Ser 
1               5                   10                  15      


Ser Val Lys Val Ser Cys Lys Ala Ser Gly Gly Thr Phe Ser Ser Tyr 
            20                  25                  30          


Ala Ile Ser Trp Val Arg Gln Ala Pro Gly Gln Gly Leu Glu Trp Met 
        35                  40                  45              


Gly Gly Ile Ile Pro Ile Phe Gly Thr Ala Asn Tyr Ala Gln Lys Phe 
    50                  55                  60                  


Gln Gly Arg Val Thr Ile Thr Ala Asp Glu Ser Thr Ser Thr Ala Tyr 
65                  70                  75                  80  


Met Glu Leu Ser Ser Leu Arg Ser Glu Asp Thr Ala Val Tyr Tyr Cys 
                85                  90                  95      


Ala Arg Gly Leu Leu Trp Asn Tyr Trp Gly Gln Gly Thr Leu Val Thr 
            100                 105                 110         


Val Ser Ser Lys Leu Ser Gly Ser Ala Ser Ala Pro Lys Leu Glu Glu 
        115                 120                 125             


Gly Glu Phe Ser Glu Ala Arg Val Glu Thr Thr Leu Thr Gln Ser Pro 
    130                 135                 140                 


Ala Thr Leu Ser Val Ser Pro Gly Glu Arg Ala Thr Leu Ser Cys Arg 
145                 150                 155                 160 


Ala Ser Gln Ser Val Ser Ser Asn Leu Ala Trp Tyr Gln Gln Lys Pro 
                165                 170                 175     


Gly Gln Ala Pro Arg Leu Leu Ile Tyr Gly Ala Ser Thr Arg Ala Thr 
            180                 185                 190         


Gly Ile Pro Ala Arg Phe Ser Gly Ser Gly Ser Gly Thr Glu Phe Thr 
        195                 200                 205             


Leu Thr Ile Ser Ser Leu Gln Ser Glu Asp Phe Ala Val Tyr Tyr Cys 
    210                 215                 220                 


Gln Gln Tyr Asn Asn Trp Pro Pro Gly Phe Thr Phe Gly Pro Gly Thr 
225                 230                 235                 240 


Lys Val Asp Ile Lys 
                245 


<210>  347
<211>  245
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic Anti EPCAM 12-C15 scFv

<400>  347

Gln Val Gln Leu Val Gln Ser Gly Ala Glu Val Lys Lys Pro Gly Ser 
1               5                   10                  15      


Ser Val Lys Val Ser Cys Lys Ala Ser Gly Gly Thr Phe Ser Ser Tyr 
            20                  25                  30          


Ala Ile Ser Trp Val Arg Gln Ala Pro Gly Gln Gly Leu Glu Trp Met 
        35                  40                  45              


Gly Gly Ile Ile Pro Ile Phe Gly Thr Ala Asn Tyr Ala Gln Lys Phe 
    50                  55                  60                  


Gln Gly Arg Val Thr Ile Thr Ala Asp Glu Ser Thr Ser Thr Ala Tyr 
65                  70                  75                  80  


Met Glu Leu Ser Ser Leu Arg Ser Glu Asp Thr Ala Val Tyr Tyr Cys 
                85                  90                  95      


Ala Arg Gly Leu Leu Trp Asn Tyr Trp Gly Gln Gly Thr Leu Val Thr 
            100                 105                 110         


Val Ser Ser Lys Leu Ser Gly Ser Ala Ser Ala Pro Lys Leu Glu Glu 
        115                 120                 125             


Gly Glu Phe Ser Glu Ala Arg Val Glu Thr Thr Leu Thr Gln Ser Pro 
    130                 135                 140                 


Ala Thr Leu Ser Leu Ser Pro Gly Glu Arg Ala Thr Leu Ser Cys Arg 
145                 150                 155                 160 


Ala Ser Gln Ser Val Ser Ser Asn Leu Ala Trp Tyr Gln Gln Lys Pro 
                165                 170                 175     


Gly Gln Ala Pro Arg Leu Leu Ile Tyr Gly Ala Ser Thr Arg Ala Thr 
            180                 185                 190         


Gly Ile Pro Ala Arg Phe Ser Gly Ser Gly Ser Gly Thr Glu Phe Thr 
        195                 200                 205             


Leu Thr Ile Ser Ser Leu Gln Ser Glu Asp Phe Ala Val Tyr Tyr Cys 
    210                 215                 220                 


Gln His Tyr Asn Asp Trp Pro Pro Thr Trp Thr Phe Gly Gln Gly Thr 
225                 230                 235                 240 


Lys Leu Glu Ile Lys 
                245 


<210>  348
<211>  245
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic Anti EPCAM 16-G5 scFv

<400>  348

Gln Val Gln Leu Val Gln Ser Gly Ala Glu Val Lys Lys Pro Gly Ser 
1               5                   10                  15      


Ser Val Lys Val Ser Cys Lys Ala Ser Gly Gly Thr Phe Ser Ser Tyr 
            20                  25                  30          


Ala Ile Ser Trp Val Arg Gln Ala Pro Gly Gln Gly Leu Glu Trp Met 
        35                  40                  45              


Gly Gly Ile Ile Pro Ile Phe Gly Thr Ala Asn Tyr Ala Gln Lys Phe 
    50                  55                  60                  


Gln Gly Arg Val Thr Ile Thr Ala Asp Glu Ser Thr Ser Thr Ala Tyr 
65                  70                  75                  80  


Met Glu Leu Ser Ser Leu Arg Ser Glu Asp Thr Ala Val Tyr Tyr Cys 
                85                  90                  95      


Ala Arg Gly Leu Leu Trp Asn Tyr Trp Gly Gln Gly Thr Leu Val Thr 
            100                 105                 110         


Val Ser Ser Lys Leu Ser Gly Ser Ala Ser Ala Pro Lys Leu Glu Glu 
        115                 120                 125             


Gly Glu Phe Ser Glu Ala Arg Val Asp Ile Val Met Thr Gln Thr Pro 
    130                 135                 140                 


Ala Thr Leu Ser Val Ser Pro Gly Glu Arg Ala Thr Leu Ser Cys Arg 
145                 150                 155                 160 


Ala Ser Gln Ser Val Ser Ser Asn Leu Ala Trp Tyr Gln Gln Lys Pro 
                165                 170                 175     


Gly Gln Ala Pro Arg Leu Leu Ile Tyr Gly Ala Ser Thr Arg Ala Thr 
            180                 185                 190         


Gly Ile Pro Ala Arg Phe Ser Gly Ser Gly Ser Gly Thr Glu Phe Thr 
        195                 200                 205             


Leu Thr Ile Ser Ser Leu Gln Ser Glu Asp Phe Ala Val Tyr Tyr Cys 
    210                 215                 220                 


Gln Gln Tyr Asn Asn Trp Pro Pro Ser Trp Thr Phe Gly Gln Gly Thr 
225                 230                 235                 240 


Lys Val Glu Ile Lys 
                245 


<210>  349
<211>  245
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic Anti EPCAM 17-C20 scFv

<400>  349

Gln Val Gln Leu Val Gln Ser Gly Ala Glu Val Lys Lys Pro Gly Ser 
1               5                   10                  15      


Ser Val Lys Val Ser Cys Lys Ala Ser Gly Gly Thr Phe Ser Ser Tyr 
            20                  25                  30          


Ala Ile Ser Trp Val Arg Gln Ala Pro Gly Gln Gly Leu Glu Trp Met 
        35                  40                  45              


Gly Gly Ile Ile Pro Ile Phe Gly Thr Ala Asn Tyr Ala Gln Lys Phe 
    50                  55                  60                  


Gln Gly Arg Val Thr Ile Thr Ala Asp Glu Ser Thr Ser Thr Ala Tyr 
65                  70                  75                  80  


Met Glu Leu Ser Ser Leu Arg Ser Glu Asp Thr Ala Val Tyr Tyr Cys 
                85                  90                  95      


Ala Arg Gly Leu Leu Trp Asn Tyr Trp Gly Gln Gly Thr Leu Val Thr 
            100                 105                 110         


Val Ser Ser Lys Leu Ser Gly Ser Ala Ser Ala Pro Lys Leu Glu Glu 
        115                 120                 125             


Gly Glu Phe Ser Glu Ala Arg Val Glu Thr Thr Leu Thr Gln Ser Pro 
    130                 135                 140                 


Ala Thr Leu Ser Val Ser Pro Gly Glu Arg Ala Thr Leu Ser Cys Arg 
145                 150                 155                 160 


Ala Ser Gln Ser Val Ser Ser Asn Leu Ala Trp Tyr Gln Gln Lys Pro 
                165                 170                 175     


Gly Gln Ala Pro Arg Leu Leu Ile Tyr Gly Ala Ser Thr Arg Ala Thr 
            180                 185                 190         


Gly Ile Pro Ala Arg Phe Ser Gly Ser Gly Ser Gly Thr Glu Phe Thr 
        195                 200                 205             


Leu Thr Ile Ser Ser Leu Gln Ser Glu Asp Phe Ala Val Tyr Tyr Cys 
    210                 215                 220                 


Gln Gln Tyr Asn Asn Trp Pro Pro Met Tyr Thr Phe Gly Gln Gly Thr 
225                 230                 235                 240 


Lys Val Glu Ile Lys 
                245 


<210>  350
<211>  245
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic Anti EPCAM 24-G6 scFv

<400>  350

Gln Val Gln Leu Val Gln Ser Gly Ala Glu Val Lys Lys Pro Gly Ser 
1               5                   10                  15      


Ser Val Lys Val Ser Cys Lys Ala Ser Gly Gly Thr Phe Ser Ser Tyr 
            20                  25                  30          


Ala Ile Ser Trp Val Arg Gln Ala Pro Gly Gln Gly Leu Glu Trp Met 
        35                  40                  45              


Gly Gly Ile Ile Pro Ile Phe Gly Thr Ala Asn Tyr Ala Gln Lys Phe 
    50                  55                  60                  


Gln Gly Arg Val Thr Ile Thr Ala Asp Glu Ser Thr Ser Thr Ala Tyr 
65                  70                  75                  80  


Met Glu Leu Ser Ser Leu Arg Ser Glu Asp Thr Ala Val Tyr Tyr Cys 
                85                  90                  95      


Ala Arg Gly Leu Leu Trp Asn Tyr Trp Gly Gln Gly Thr Leu Val Thr 
            100                 105                 110         


Val Ser Ser Lys Leu Ser Gly Ser Ala Ser Ala Pro Lys Leu Glu Glu 
        115                 120                 125             


Gly Glu Phe Ser Glu Ala Arg Val Glu Thr Thr Leu Thr Gln Ser Pro 
    130                 135                 140                 


Ala Thr Leu Ser Val Ser Pro Gly Glu Arg Ala Thr Leu Ser Cys Arg 
145                 150                 155                 160 


Ala Ser Gln Ser Val Ser Ser Asn Leu Ala Trp Tyr Gln Gln Lys Pro 
                165                 170                 175     


Gly Gln Ala Pro Arg Leu Leu Ile Tyr Gly Ala Ser Thr Arg Ala Thr 
            180                 185                 190         


Gly Ile Pro Ala Arg Phe Ser Gly Ser Gly Ser Gly Thr Glu Phe Thr 
        195                 200                 205             


Leu Thr Ile Ser Ser Leu Gln Ser Glu Asp Phe Ala Val Tyr Tyr Cys 
    210                 215                 220                 


Gln Lys Tyr Asn Asn Trp Pro Pro Ala Phe Thr Phe Gly Pro Gly Thr 
225                 230                 235                 240 


Lys Val Asp Ile Lys 
                245 


<210>  351
<211>  115
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic Anti EPCAM variable heavy chain

<400>  351

Gln Val Gln Leu Val Gln Ser Gly Ala Glu Val Lys Lys Pro Gly Ser 
1               5                   10                  15      


Ser Val Lys Val Ser Cys Lys Ala Ser Gly Gly Thr Phe Ser Ser Tyr 
            20                  25                  30          


Ala Ile Ser Trp Val Arg Gln Ala Pro Gly Gln Gly Leu Glu Trp Met 
        35                  40                  45              


Gly Gly Ile Ile Pro Ile Phe Gly Thr Ala Asn Tyr Ala Gln Lys Phe 
    50                  55                  60                  


Gln Gly Arg Val Thr Ile Thr Ala Asp Glu Ser Thr Ser Thr Ala Tyr 
65                  70                  75                  80  


Met Glu Leu Ser Ser Leu Arg Ser Glu Asp Thr Ala Val Tyr Tyr Cys 
                85                  90                  95      


Ala Arg Gly Leu Leu Trp Asn Tyr Trp Gly Gln Gly Thr Leu Val Thr 
            100                 105                 110         


Val Ser Ser 
        115 


<210>  352
<211>  109
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic Anti EPCAM variable light chain

<400>  352

Glu Ile Val Met Thr Gln Ser Pro Ala Thr Leu Ser Val Ser Pro Gly 
1               5                   10                  15      


Glu Arg Ala Thr Leu Ser Cys Arg Ala Ser Gln Ser Val Ser Ser Asn 
            20                  25                  30          


Leu Ala Trp Tyr Gln Gln Lys Pro Gly Gln Ala Pro Arg Leu Ile Ile 
        35                  40                  45              


Tyr Gly Ala Ser Thr Thr Ala Ser Gly Ile Pro Ala Arg Phe Ser Ala 
    50                  55                  60                  


Ser Gly Ser Gly Thr Asp Phe Thr Leu Thr Ile Ser Ser Leu Gln Ser 
65                  70                  75                  80  


Glu Asp Phe Ala Val Tyr Tyr Cys Gln Gln Tyr Asn Asn Trp Pro Pro 
                85                  90                  95      


Ala Tyr Thr Phe Gly Gln Gly Thr Lys Leu Glu Ile Lys 
            100                 105                 


<210>  353
<211>  109
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic Anti EPCAM variable light chain

<400>  353

Glu Thr Thr Leu Thr Gln Ser Pro Ala Thr Leu Ser Val Ser Pro Gly 
1               5                   10                  15      


Glu Arg Ala Thr Leu Ser Cys Arg Ala Ser Gln Ser Val Ser Ser Asn 
            20                  25                  30          


Leu Ala Trp Tyr Gln Gln Lys Pro Gly Gln Ala Pro Arg Leu Leu Ile 
        35                  40                  45              


Tyr Gly Ala Ser Thr Arg Ala Thr Gly Ile Pro Ala Arg Phe Ser Gly 
    50                  55                  60                  


Ser Gly Ser Gly Thr Glu Phe Thr Leu Thr Ile Ser Ser Leu Gln Ser 
65                  70                  75                  80  


Glu Asp Phe Ala Val Tyr Tyr Cys Gln Gln Tyr Asn Asn Trp Pro Pro 
                85                  90                  95      


Gly Phe Thr Phe Gly Pro Gly Thr Lys Val Asp Ile Lys 
            100                 105                 


<210>  354
<211>  109
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic Anti EPCAM variable light chain

<400>  354

Glu Thr Thr Leu Thr Gln Ser Pro Ala Thr Leu Ser Leu Ser Pro Gly 
1               5                   10                  15      


Glu Arg Ala Thr Leu Ser Cys Arg Ala Ser Gln Ser Val Ser Ser Asn 
            20                  25                  30          


Leu Ala Trp Tyr Gln Gln Lys Pro Gly Gln Ala Pro Arg Leu Leu Ile 
        35                  40                  45              


Tyr Gly Ala Ser Thr Arg Ala Thr Gly Ile Pro Ala Arg Phe Ser Gly 
    50                  55                  60                  


Ser Gly Ser Gly Thr Glu Phe Thr Leu Thr Ile Ser Ser Leu Gln Ser 
65                  70                  75                  80  


Glu Asp Phe Ala Val Tyr Tyr Cys Gln His Tyr Asn Asp Trp Pro Pro 
                85                  90                  95      


Thr Trp Thr Phe Gly Gln Gly Thr Lys Leu Glu Ile Lys 
            100                 105                 


<210>  355
<211>  109
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic Anti EPCAM variable light chain

<400>  355

Asp Ile Val Met Thr Gln Thr Pro Ala Thr Leu Ser Val Ser Pro Gly 
1               5                   10                  15      


Glu Arg Ala Thr Leu Ser Cys Arg Ala Ser Gln Ser Val Ser Ser Asn 
            20                  25                  30          


Leu Ala Trp Tyr Gln Gln Lys Pro Gly Gln Ala Pro Arg Leu Leu Ile 
        35                  40                  45              


Tyr Gly Ala Ser Thr Arg Ala Thr Gly Ile Pro Ala Arg Phe Ser Gly 
    50                  55                  60                  


Ser Gly Ser Gly Thr Glu Phe Thr Leu Thr Ile Ser Ser Leu Gln Ser 
65                  70                  75                  80  


Glu Asp Phe Ala Val Tyr Tyr Cys Gln Gln Tyr Asn Asn Trp Pro Pro 
                85                  90                  95      


Ser Trp Thr Phe Gly Gln Gly Thr Lys Val Glu Ile Lys 
            100                 105                 


<210>  356
<211>  109
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic Anti EPCAM variable light chain

<400>  356

Glu Thr Thr Leu Thr Gln Ser Pro Ala Thr Leu Ser Val Ser Pro Gly 
1               5                   10                  15      


Glu Arg Ala Thr Leu Ser Cys Arg Ala Ser Gln Ser Val Ser Ser Asn 
            20                  25                  30          


Leu Ala Trp Tyr Gln Gln Lys Pro Gly Gln Ala Pro Arg Leu Leu Ile 
        35                  40                  45              


Tyr Gly Ala Ser Thr Arg Ala Thr Gly Ile Pro Ala Arg Phe Ser Gly 
    50                  55                  60                  


Ser Gly Ser Gly Thr Glu Phe Thr Leu Thr Ile Ser Ser Leu Gln Ser 
65                  70                  75                  80  


Glu Asp Phe Ala Val Tyr Tyr Cys Gln Gln Tyr Asn Asn Trp Pro Pro 
                85                  90                  95      


Met Tyr Thr Phe Gly Gln Gly Thr Lys Val Glu Ile Lys 
            100                 105                 


<210>  357
<211>  109
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic Anti EPCAM variable light chain

<400>  357

Glu Thr Thr Leu Thr Gln Ser Pro Ala Thr Leu Ser Val Ser Pro Gly 
1               5                   10                  15      


Glu Arg Ala Thr Leu Ser Cys Arg Ala Ser Gln Ser Val Ser Ser Asn 
            20                  25                  30          


Leu Ala Trp Tyr Gln Gln Lys Pro Gly Gln Ala Pro Arg Leu Leu Ile 
        35                  40                  45              


Tyr Gly Ala Ser Thr Arg Ala Thr Gly Ile Pro Ala Arg Phe Ser Gly 
    50                  55                  60                  


Ser Gly Ser Gly Thr Glu Phe Thr Leu Thr Ile Ser Ser Leu Gln Ser 
65                  70                  75                  80  


Glu Asp Phe Ala Val Tyr Tyr Cys Gln Lys Tyr Asn Asn Trp Pro Pro 
                85                  90                  95      


Ala Phe Thr Phe Gly Pro Gly Thr Lys Val Asp Ile Lys 
            100                 105                 


<210>  358
<211>  5
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic Anti EPCAM CDR1 heavy chain

<400>  358

Ser Tyr Ala Ile Ser 
1               5   


<210>  359
<211>  17
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic Anti EPCAM CDR2 heavy chain

<400>  359

Gly Ile Ile Pro Ile Phe Gly Thr Ala Asn Tyr Ala Gln Lys Phe Gln 
1               5                   10                  15      


Gly 
    


<210>  360
<211>  6
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic Anti EPCMA CDR3 heavy chain

<400>  360

Gly Leu Leu Trp Asn Tyr 
1               5       


<210>  361
<211>  11
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic Anti EPCAM CDR1 light chain

<400>  361

Arg Ala Ser Gln Ser Val Ser Ser Asn Leu Ala 
1               5                   10      


<210>  362
<211>  7
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic Anti EPCAM CDR2 light chain

<400>  362

Gly Ala Ser Thr Thr Ala Ser 
1               5           


<210>  363
<211>  11
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic Anti EPCAM CDR3 light chain

<400>  363

Gln Gln Tyr Asn Asn Trp Pro Pro Ala Tyr Thr 
1               5                   10      


<210>  364
<211>  735
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Synthetic Anti EPCAM 3-17I scFv

<400>  364
caggtccagc tggtgcagtc tggggctgag gtgaagaagc ctgggtcctc ggtgaaggtc       60

tcctgcaagg cttctggagg caccttcagc agctatgcta tcagctgggt gcgacaggcc      120

cctggacaag ggcttgagtg gatgggaggg atcatcccta tctttggtac agcaaactac      180

gcacagaagt tccagggcag agtcacgatt accgcggacg aatccacgag cacagcctac      240

atggagctga gcagcctgag atctgaggac acggccgtgt attactgtgc gagaggcctt      300

ctatggaact actggggcca gggaaccctg gtcaccgtct cctcaaagct ttcagggagt      360

gcatccgccc caaaacttga agaaggtgaa ttttcagaag cacgcgtaga aattgtaatg      420

acacagtctc cagccaccct gtctgtgtct ccaggggaaa gagccaccct ctcctgcagg      480

gccagtcaga gtgttagcag caacttagcc tggtaccagc agaaacctgg ccaggctccc      540

aggctcatca tctatggtgc atccaccacg gcctctggta tcccagccag gttcagtgcc      600

agtgggtctg ggacagactt cactctcacc atcagcagcc tgcagtctga agattttgca      660

gtttattact gtcagcagta taataactgg cctccggcgt acacttttgg ccaggggacc      720

aagctggaga tcaaa                                                       735


<210>  365
<211>  735
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Synthetic Anti EPCAM 7-F17 scFv

<400>  365
caggtccagc tggtgcagtc tggggctgag gtgaagaagc ctgggtcctc ggtgaaggtc       60

tcctgcaagg cttctggagg caccttcagc agctatgcta tcagctgggt gcgacaggcc      120

cctggacaag ggcttgagtg gatgggaggg atcatcccta tctttggtac agcaaactac      180

gcacagaagt tccagggcag agtcacgatt accgcggacg aatccacgag cacagcctac      240

atggagctga gcagcctgag atctgaggac acggccgtgt attactgtgc gagaggcctt      300

ctatggaact actggggcca gggaaccctg gtcaccgtct cctcaaagct ttcagggagt      360

gcatccgccc caaaacttga agaaggtgaa ttttcagaag cacgcgtaga aacgacactc      420

acgcagtctc cagccaccct gtctgtgtct ccaggggaaa gagccaccct ctcctgcagg      480

gccagtcaga gtgttagcag caacttagcc tggtaccagc agaaacctgg ccaggctccc      540

aggctcctca tctatggtgc atccaccagg gccactggta tcccagccag gttcagtggc      600

agtgggtctg ggacagagtt cactctcacc atcagcagcc tgcagtctga agattttgca      660

gtttattact gtcagcagta taataactgg cctccggggt tcactttcgg ccctgggacc      720

aaagtggata tcaaa                                                       735


<210>  366
<211>  735
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Synthetic Anti EPCAM 12-C15 scFv

<400>  366
caggtccagc tggtgcagtc tggggctgag gtgaagaagc ctgggtcctc ggtgaaggtc       60

tcctgcaagg cttctggagg caccttcagc agctatgcta tcagctgggt gcgacaggcc      120

cctggacaag ggcttgagtg gatgggaggg atcatcccta tctttggtac agcaaactac      180

gcacagaagt tccagggcag agtcacgatt accgcggacg aatccacgag cacagcctac      240

atggagctga gcagcctgag atctgaggac acggccgtgt attactgtgc gagaggcctt      300

ctatggaact actggggcca gggaaccctg gtcaccgtct cctcaaagct ttcagggagt      360

gcatccgccc caaaacttga agaaggtgaa ttttcagaag cacgcgtaga aacgacactc      420

acgcagtctc cagccaccct gtctttgtct ccaggggaaa gagccaccct ctcctgcagg      480

gccagtcaga gtgttagcag caacttagcc tggtaccagc agaaacctgg ccaggctccc      540

aggctcctca tctatggtgc atccaccagg gccactggta tcccagccag gttcagtggc      600

agtgggtctg ggacagagtt cactctcacc atcagcagcc tgcagtctga agattttgca      660

gtttattact gtcagcacta taatgactgg cctcccacgt ggacgttcgg ccaagggacc      720

aagctggaga tcaaa                                                       735


<210>  367
<211>  735
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Synthetic Anti EPCAM 16-G5 scFv

<400>  367
caggtccagc tggtgcagtc tggggctgag gtgaagaagc ctgggtcctc ggtgaaggtc       60

tcctgcaagg cttctggagg caccttcagc agctatgcta tcagctgggt gcgacaggcc      120

cctggacaag ggcttgagtg gatgggaggg atcatcccta tctttggtac agcaaactac      180

gcacagaagt tccagggcag agtcacgatt accgcggacg aatccacgag cacagcctac      240

atggagctga gcagcctgag atctgaggac acggccgtgt attactgtgc gagaggcctt      300

ctatggaact actggggcca gggaaccctg gtcaccgtct cctcaaagct ttcagggagt      360

gcatccgccc caaaacttga agaaggtgaa ttttcagaag cacgcgtaga tattgtgatg      420

actcagactc cagccaccct gtctgtgtct ccaggggaaa gagccaccct ctcctgcagg      480

gccagtcaga gtgttagcag caacttagcc tggtaccagc agaaacctgg ccaggctccc      540

aggctcctca tctatggtgc atccaccagg gccactggta tcccagccag gttcagtggc      600

agtgggtctg ggacagagtt cactctcacc atcagcagcc tgcagtctga agattttgca      660

gtttattact gtcagcagta taataactgg cctccgtcgt ggacgttcgg ccaagggacc      720

aaggtggaga tcaaa                                                       735


<210>  368
<211>  735
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Synthetic Anti EPCAM 17-C20 scFv

<400>  368
caggtccagc tggtgcagtc tggggctgag gtgaagaagc ctgggtcctc ggtgaaggtc       60

tcctgcaagg cttctggagg caccttcagc agctatgcta tcagctgggt gcgacaggcc      120

cctggacaag ggcttgagtg gatgggaggg atcatcccta tctttggtac agcaaactac      180

gcacagaagt tccagggcag agtcacgatt accgcggacg aatccacgag cacagcctac      240

atggagctga gcagcctgag atctgaggac acggccgtgt attactgtgc gagaggcctt      300

ctatggaact actggggcca gggaaccctg gtcaccgtct cctcaaagct ttcagggagt      360

gcatccgccc caaaacttga agaaggtgaa ttttcagaag cacgcgtaga aacgacactc      420

acgcagtctc cagccaccct gtctgtgtct ccaggggaaa gagccaccct ctcctgcagg      480

gccagtcaga gtgttagcag caacttagcc tggtaccagc agaaacctgg ccaggctccc      540

aggctcctca tctatggtgc atccaccagg gccactggta tcccagccag gttcagtggc      600

agtgggtctg ggacagagtt cactctcacc atcagcagcc tgcagtctga agattttgca      660

gtttattact gtcagcagta taataactgg cctccgatgt acacttttgg ccaggggacc      720

aaggtggaga tcaaa                                                       735


<210>  369
<211>  735
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Synthetic Anti EPCAM 24-G6 scFv

<400>  369
caggtccagc tggtgcagtc tggggctgag gtgaagaagc ctgggtcctc ggtgaaggtc       60

tcctgcaagg cttctggagg caccttcagc agctatgcta tcagctgggt gcgacaggcc      120

cctggacaag ggcttgagtg gatgggaggg atcatcccta tctttggtac agcaaactac      180

gcacagaagt tccagggcag agtcacgatt accgcggacg aatccacgag cacagcctac      240

atggagctga gcagcctgag atctgaggac acggccgtgt attactgtgc gagaggcctt      300

ctatggaact actggggcca gggaaccctg gtcaccgtct cctcaaagct ttcagggagt      360

gcatccgccc caaaacttga agaaggtgaa ttttcagaag cacgcgtaga aacgacactc      420

acgcagtctc cagccaccct gtctgtgtct ccaggggaaa gagccaccct ctcctgcagg      480

gccagtcaga gtgttagcag caacttagcc tggtaccagc agaaacctgg ccaggctccc      540

aggctcctca tctatggtgc atccaccagg gccactggta tcccagccag gttcagtggc      600

agtgggtctg ggacagagtt cactctcacc atcagcagcc tgcagtctga agattttgca      660

gtttattact gtcagaagta taataactgg cctccggcct tcactttcgg ccctgggacc      720

aaagtggata tcaaa                                                       735


<210>  370
<211>  345
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Synthetic Anti EPCAM variable heavy chain

<400>  370
caggtccagc tggtgcagtc tggggctgag gtgaagaagc ctgggtcctc ggtgaaggtc       60

tcctgcaagg cttctggagg caccttcagc agctatgcta tcagctgggt gcgacaggcc      120

cctggacaag ggcttgagtg gatgggaggg atcatcccta tctttggtac agcaaactac      180

gcacagaagt tccagggcag agtcacgatt accgcggacg aatccacgag cacagcctac      240

atggagctga gcagcctgag atctgaggac acggccgtgt attactgtgc gagaggcctt      300

ctatggaact actggggcca gggaaccctg gtcaccgtct cctca                      345


<210>  371
<211>  327
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Synthetic Anti EPCAM variable light chain

<400>  371
gaaattgtaa tgacacagtc tccagccacc ctgtctgtgt ctccagggga aagagccacc       60

ctctcctgca gggccagtca gagtgttagc agcaacttag cctggtacca gcagaaacct      120

ggccaggctc ccaggctcat catctatggt gcatccacca cggcctctgg tatcccagcc      180

aggttcagtg ccagtgggtc tgggacagac ttcactctca ccatcagcag cctgcagtct      240

gaagattttg cagtttatta ctgtcagcag tataataact ggcctccggc gtacactttt      300

ggccagggga ccaagctgga gatcaaa                                          327


<210>  372
<211>  327
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Synthetic Anti EPCAM variable light chain

<400>  372
gaaacgacac tcacgcagtc tccagccacc ctgtctgtgt ctccagggga aagagccacc       60

ctctcctgca gggccagtca gagtgttagc agcaacttag cctggtacca gcagaaacct      120

ggccaggctc ccaggctcct catctatggt gcatccacca gggccactgg tatcccagcc      180

aggttcagtg gcagtgggtc tgggacagag ttcactctca ccatcagcag cctgcagtct      240

gaagattttg cagtttatta ctgtcagcag tataataact ggcctccggg gttcactttc      300

ggccctggga ccaaagtgga tatcaaa                                          327


<210>  373
<211>  327
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Synthetic Anti EPCAM variable light chain

<400>  373
gaaacgacac tcacgcagtc tccagccacc ctgtctttgt ctccagggga aagagccacc       60

ctctcctgca gggccagtca gagtgttagc agcaacttag cctggtacca gcagaaacct      120

ggccaggctc ccaggctcct catctatggt gcatccacca gggccactgg tatcccagcc      180

aggttcagtg gcagtgggtc tgggacagag ttcactctca ccatcagcag cctgcagtct      240

gaagattttg cagtttatta ctgtcagcac tataatgact ggcctcccac gtggacgttc      300

ggccaaggga ccaagctgga gatcaaa                                          327


<210>  374
<211>  327
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Synthetic Anti EPCAM variable light chain

<400>  374
gatattgtga tgactcagac tccagccacc ctgtctgtgt ctccagggga aagagccacc       60

ctctcctgca gggccagtca gagtgttagc agcaacttag cctggtacca gcagaaacct      120

ggccaggctc ccaggctcct catctatggt gcatccacca gggccactgg tatcccagcc      180

aggttcagtg gcagtgggtc tgggacagag ttcactctca ccatcagcag cctgcagtct      240

gaagattttg cagtttatta ctgtcagcag tataataact ggcctccgtc gtggacgttc      300

ggccaaggga ccaaggtgga gatcaaa                                          327


<210>  375
<211>  327
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Synthetic

<400>  375
gaaacgacac tcacgcagtc tccagccacc ctgtctgtgt ctccagggga aagagccacc       60

ctctcctgca gggccagtca gagtgttagc agcaacttag cctggtacca gcagaaacct      120

ggccaggctc ccaggctcct catctatggt gcatccacca gggccactgg tatcccagcc      180

aggttcagtg gcagtgggtc tgggacagag ttcactctca ccatcagcag cctgcagtct      240

gaagattttg cagtttatta ctgtcagcag tataataact ggcctccgat gtacactttt      300

ggccagggga ccaaggtgga gatcaaa                                          327


<210>  376
<211>  327
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Synthetic Anti EPCAM variable light chain

<400>  376
gaaacgacac tcacgcagtc tccagccacc ctgtctgtgt ctccagggga aagagccacc       60

ctctcctgca gggccagtca gagtgttagc agcaacttag cctggtacca gcagaaacct      120

ggccaggctc ccaggctcct catctatggt gcatccacca gggccactgg tatcccagcc      180

aggttcagtg gcagtgggtc tgggacagag ttcactctca ccatcagcag cctgcagtct      240

gaagattttg cagtttatta ctgtcagaag tataataact ggcctccggc cttcactttc      300

ggccctggga ccaaagtgga tatcaaa                                          327


<210>  377
<211>  123
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic Anti EPCAM variable heavy chain

<400>  377

Gln Val Gln Leu Gln Glu Ser Gly Gly Gly Leu Val Gln Pro Gly Gly 
1               5                   10                  15      


Ser Leu Arg Leu Ser Cys Thr Thr Ser Gly Phe Thr Phe Thr Ser Tyr 
            20                  25                  30          


Ala Met Ser Trp Val Arg Gln Ala Pro Gly Lys Gly Leu Glu Trp Val 
        35                  40                  45              


Ser Ser Ile Ser Gly Ser Gly Gly Ile Thr Tyr Tyr Ala Asp Ser Val 
    50                  55                  60                  


Lys Gly Arg Phe Thr Ile Ser Arg Asp Asn Ser Lys Asn Thr Leu Tyr 
65                  70                  75                  80  


Leu Gln Met Asn Ser Leu Arg Ala Glu Asp Thr Ala Val Tyr Tyr Cys 
                85                  90                  95      


Ala Lys Asp Arg Val Leu Val Pro Ala Ser Ser Ser Tyr Phe Asp Tyr 
            100                 105                 110         


Trp Gly Gln Gly Thr Leu Val Thr Val Ser Arg 
        115                 120             


<210>  378
<211>  109
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic Anti EPCAM variable light chain

<400>  378

Ser Ser Glu Leu Thr Gln Asp Pro Ala Val Ser Val Ala Leu Gly Gln 
1               5                   10                  15      


Thr Val Arg Ile Thr Cys Gln Gly Asp Ser Leu Arg Ser Tyr Tyr Ala 
            20                  25                  30          


Ser Trp Tyr Gln Gln Lys Pro Gly Gln Ala Pro Val Leu Val Ile Tyr 
        35                  40                  45              


Gly Lys Asn Asn Arg Pro Ser Gly Ile Pro Asp Arg Phe Ser Gly Ser 
    50                  55                  60                  


Ser Ser Gly Asn Thr Ala Ser Leu Thr Ile Thr Gly Ala Gln Ala Glu 
65                  70                  75                  80  


Asp Glu Ala Asp Tyr Tyr Cys Asn Ser Arg Asp Ser Ser Gly Asn His 
                85                  90                  95      


Val Val Phe Gly Gly Gly Thr Lys Leu Thr Val Leu Gly 
            100                 105                 


<210>  379
<211>  5
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic Anti EPCAM CDR1 heavy chain

<400>  379

Ser Tyr Ala Met Ser 
1               5   


<210>  380
<211>  17
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic Anti EPCAM CDR2 heavy chain

<400>  380

Ser Ile Ser Gly Ser Gly Gly Ile Thr Tyr Tyr Ala Asp Ser Val Lys 
1               5                   10                  15      


Gly 
    


<210>  381
<211>  14
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic Anti EPCAM CDR3 heavy chain

<400>  381

Asp Arg Val Leu Val Pro Ala Ser Ser Ser Tyr Phe Asp Tyr 
1               5                   10                  


<210>  382
<211>  11
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic Anti EPCAM CDR1 light chain

<400>  382

Gln Gly Asp Ser Leu Arg Ser Tyr Tyr Ala Ser 
1               5                   10      


<210>  383
<211>  7
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic Anti EPCAM CDR2 light chain

<400>  383

Gly Lys Asn Asn Arg Pro Ser 
1               5           


<210>  384
<211>  9
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic Anti EPCAM CDR3 light chain

<400>  384

Asn Ser Arg Asp Ser Ser Gly Asn His 
1               5                   


<210>  385
<211>  116
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic Anti TF variable heavy chain TF260

<400>  385

Gln Val Gln Leu Lys Gln Ser Gly Ala Glu Leu Met Lys Pro Gly Ala 
1               5                   10                  15      


Ser Val Lys Ile Ser Cys Lys Ala Thr Gly Tyr Thr Phe Ser Ser Tyr 
            20                  25                  30          


Trp Ile Glu Trp Val Lys Gln Arg Pro Gly His Gly Leu Glu Trp Ile 
        35                  40                  45              


Gly Glu Ile Leu Pro Gly Ser Gly Ser Thr Asn Tyr Asn Glu Lys Phe 
    50                  55                  60                  


Lys Gly Lys Ala Thr Phe Thr Ala Asp Thr Ser Ser Asn Thr Ala Tyr 
65                  70                  75                  80  


Met Gln Leu Ser Ser Leu Thr Ser Glu Asp Ser Ala Val Tyr Tyr Cys 
                85                  90                  95      


Ala Arg Glu Asp Arg Tyr Asp Gly Asp Tyr Trp Gly Gln Gly Thr Thr 
            100                 105                 110         


Leu Thr Val Ser 
        115     


<210>  386
<211>  112
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic Anti TF variable light chain TF260

<400>  386

Gln Ala Val Val Thr Gln Glu Ser Ala Leu Thr Thr Ser Pro Gly Glu 
1               5                   10                  15      


Thr Val Thr Leu Thr Cys Arg Ser Ser Thr Gly Ala Val Thr Thr Ser 
            20                  25                  30          


Asn Tyr Ala Asn Trp Val Gln Glu Lys Pro Asp His Leu Phe Thr Gly 
        35                  40                  45              


Leu Ile Gly Gly Thr Asn Asn Arg Ala Pro Gly Val Pro Ala Arg Phe 
    50                  55                  60                  


Ser Gly Ser Leu Ile Gly Asp Lys Ala Ala Leu Thr Ile Thr Gly Ala 
65                  70                  75                  80  


Gln Thr Glu Asp Glu Ala Ile Tyr Phe Cys Ala Leu Trp Tyr Ser Asn 
                85                  90                  95      


His Trp Val Phe Gly Gly Gly Thr Lys Leu Thr Val Leu Gly Gln Pro 
            100                 105                 110         


<210>  387
<211>  117
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic Anti TF variable heavy chain TF196

<400>  387

Gln Val Gln Leu Lys Gln Ser Gly Pro Glu Leu Glu Lys Pro Gly Ala 
1               5                   10                  15      


Ser Val Lys Ile Ser Cys Lys Ala Ser Gly Tyr Ser Phe Thr Gly Tyr 
            20                  25                  30          


Asn Met Asn Trp Val Lys Gln Ser Asn Gly Lys Ser Leu Glu Trp Ile 
        35                  40                  45              


Gly Asn Ile Asp Pro Tyr Tyr Gly Gly Thr Ser Tyr Asn Gln Lys Phe 
    50                  55                  60                  


Lys Gly Lys Ala Thr Leu Thr Val Asp Lys Ser Ser Asn Thr Ala Tyr 
65                  70                  75                  80  


Met His Leu Lys Ser Leu Thr Ser Glu Asp Ser Ala Val Tyr Tyr Cys 
                85                  90                  95      


Ala Arg Asp Ser Ser Ser Trp Phe Ala Tyr Trp Gly Gln Gly Thr Leu 
            100                 105                 110         


Val Thr Val Ser Ala 
        115         


<210>  388
<211>  106
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic Anti TF variable light chain TF196

<400>  388

Asp Ile Gln Leu Thr Gln Ser Pro Ala Ser Leu Ser Ala Ser Val Gly 
1               5                   10                  15      


Glu Thr Val Thr Ile Thr Cys Arg Ala Ser Gly Asn Ile His Asn Tyr 
            20                  25                  30          


Leu Ala Trp Tyr Gln Gln Lys Gln Gly Lys Ser Pro Gln Leu Leu Val 
        35                  40                  45              


Tyr Asn Ala Lys Thr Leu Ala Asp Gly Val Pro Ser Arg Phe Ser Gly 
    50                  55                  60                  


Ser Gly Ser Gly Thr Gln Tyr Ser Leu Lys Ile Asn Ser Leu Gln Pro 
65                  70                  75                  80  


Glu Asp Phe Gly Ser Tyr Tyr Cys Gln His Phe Trp Ile Thr Pro Trp 
                85                  90                  95      


Thr Phe Gly Gly Gly Thr Lys Leu Glu Ile 
            100                 105     


<210>  389
<211>  121
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic Anti TF variable heavy chain TF278

<400>  389

Glu Val Gln Leu Gln Gln Ser Gly Ala Glu Leu Met Lys Pro Gly Ala 
1               5                   10                  15      


Ser Val Lys Ile Ser Cys Lys Ala Thr Gly Tyr Thr Phe Ser Ser Tyr 
            20                  25                  30          


Trp Ile Glu Trp Val Lys Gln Arg Pro Gly His Gly Leu Glu Trp Ile 
        35                  40                  45              


Gly Glu Ile Leu Pro Gly Ser Ala Ser Thr Lys Tyr Asn Glu Lys Phe 
    50                  55                  60                  


Lys Gly Lys Ala Thr Phe Thr Ala Asp Thr Ser Ser Asn Thr Ala Tyr 
65                  70                  75                  80  


Met Gln Leu Ser Ser Leu Thr Ser Glu Asp Ser Ala Val Tyr Tyr Cys 
                85                  90                  95      


Ala Arg Asp Tyr Tyr Tyr Gly Ser Ser Tyr Gly Phe Ala Tyr Trp Gly 
            100                 105                 110         


Gln Gly Thr Leu Val Thr Val Ser Ser 
        115                 120     


<210>  390
<211>  110
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic Anti TF variable light chain TF278

<400>  390

Gln Ala Val Val Thr Gln Glu Ser Ala Leu Thr Thr Ser Pro Gly Glu 
1               5                   10                  15      


Thr Val Thr Leu Thr Cys Arg Ser Ser Thr Gly Ala Val Thr Thr Ser 
            20                  25                  30          


Asn Tyr Ala Asn Trp Val Gln Glu Lys Pro Asp His Leu Phe Thr Gly 
        35                  40                  45              


Leu Ile Gly Gly Thr Asn Asn Arg Gly Pro Gly Val Pro Ala Arg Phe 
    50                  55                  60                  


Ser Gly Ser Leu Ile Gly Asp Lys Ala Ala Leu Thr Ile Thr Gly Ala 
65                  70                  75                  80  


Gln Thr Glu Asp Glu Ala Val Tyr Phe Cys Ala Leu Trp Tyr Ser Asn 
                85                  90                  95      


His Trp Val Phe Gly Gly Gly Thr Lys Leu Thr Val Leu Gly 
            100                 105                 110 


<210>  391
<211>  118
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic Anti TF variable heavy chain TF277

<400>  391

Gln Val Gln Leu Gln Gln Pro Gly Ala Glu Leu Val Lys Pro Gly Ala 
1               5                   10                  15      


Ser Val Lys Leu Ser Cys Lys Thr Ser Gly Tyr Thr Phe Thr Ser Tyr 
            20                  25                  30          


Trp Met His Trp Val Lys Gln Arg Pro Gly Gln Gly Leu Glu Trp Ile 
        35                  40                  45              


Gly Glu Ile Asp Pro Ser Asp Ser Tyr Thr Asn Tyr Asn Gln Lys Phe 
    50                  55                  60                  


Lys Gly Lys Ala Thr Leu Thr Val Asp Lys Ser Ser Ser Thr Ala Tyr 
65                  70                  75                  80  


Met Gln Leu Ser Ser Leu Thr Ser Glu Asp Ser Ala Val Tyr Tyr Cys 
                85                  90                  95      


Thr Tyr Tyr Val Asn Tyr Tyr Ala Met Asp Tyr Trp Gly Gln Gly Thr 
            100                 105                 110         


Ser Val Thr Val Ser Ser 
        115             


<210>  392
<211>  106
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic Anti TF variable light chain TF277

<400>  392

Gln Ile Val Leu Thr Gln Ser Pro Ala Ile Met Ser Ala Ser Leu Gly 
1               5                   10                  15      


Glu Glu Ile Thr Leu Thr Cys Ser Ala Ser Ser Ser Val Ser Tyr Met 
            20                  25                  30          


His Trp Tyr Gln Gln Lys Ser Gly Thr Ser Pro Lys Leu Leu Ile Tyr 
        35                  40                  45              


Ser Thr Ser Asn Leu Ala Ser Gly Val Pro Ser Arg Phe Ser Gly Ser 
    50                  55                  60                  


Gly Ser Gly Thr Phe Tyr Ser Leu Thr Ile Ser Ser Val Glu Ala Glu 
65                  70                  75                  80  


Asp Ala Ala Asp Tyr Tyr Cys His Gln Trp Ser Ser Tyr Pro Tyr Thr 
                85                  90                  95      


Phe Gly Gly Gly Thr Lys Leu Glu Ile Lys 
            100                 105     


<210>  393
<211>  120
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic Anti TF variable heavy chain TF392

<400>  393

Gln Val Gln Leu Lys Glu Ser Gly Ala Glu Leu Met Lys Pro Gly Ala 
1               5                   10                  15      


Ser Val Lys Ile Ser Cys Lys Ala Thr Gly Tyr Thr Phe Ser Ser Tyr 
            20                  25                  30          


Trp Ile Glu Trp Val Lys Gln Arg Pro Gly His Gly Leu Glu Trp Ile 
        35                  40                  45              


Gly Glu Ile Leu Pro Gly Ser Gly Ser Thr Asn Tyr Asn Glu Lys Phe 
    50                  55                  60                  


Lys Gly Lys Ala Thr Phe Thr Ala Asp Thr Ser Ser Asn Thr Ala Tyr 
65                  70                  75                  80  


Met Gln Leu Ser Ser Leu Thr Ser Glu Asp Ser Ala Val Tyr Tyr Cys 
                85                  90                  95      


Ala Arg Asp Arg Asn Gly Tyr Val Asn Tyr Phe Asp Ser Trp Gly Gln 
            100                 105                 110         


Gly Thr Thr Leu Thr Val Ser Ser 
        115                 120 


<210>  394
<211>  112
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic Anti TF variable light chain TF392

<400>  394

Gln Ala Val Val Thr Gln Glu Ser Ala Leu Thr Thr Ser Pro Gly Glu 
1               5                   10                  15      


Thr Val Thr Leu Thr Cys Arg Ser Ser Thr Gly Ala Val Thr Thr Ser 
            20                  25                  30          


Asn Tyr Ala Asn Trp Val Gln Glu Lys Pro Asp His Leu Phe Thr Gly 
        35                  40                  45              


Leu Ile Gly Gly Thr Asn Asn Arg Ala Pro Gly Val Pro Ala Arg Phe 
    50                  55                  60                  


Ser Gly Ser Leu Ile Gly Asp Lys Ala Ala Leu Thr Ile Thr Gly Ala 
65                  70                  75                  80  


Gln Thr Glu Asp Glu Ala Ile Tyr Phe Cys Ala Leu Trp Tyr Ser Asn 
                85                  90                  95      


His Trp Val Phe Gly Gly Gly Thr Lys Leu Thr Val Leu Gly Gln Pro 
            100                 105                 110         


<210>  395
<211>  117
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic Anti TF variable heavy chain TF9

<400>  395

Asp Val Lys Leu Gln Glu Ser Gly Pro Asp Leu Val Lys Pro Ser Gln 
1               5                   10                  15      


Ser Leu Ser Leu Thr Cys Thr Val Thr Gly Tyr Ser Ile Thr Ser Gly 
            20                  25                  30          


Tyr Ser Trp His Trp Ile Arg Gln Phe Pro Gly Asn Lys Leu Glu Trp 
        35                  40                  45              


Met Gly Tyr Ile His Tyr Ser Gly Ser Thr Lys Tyr Asn Pro Ser Leu 
    50                  55                  60                  


Lys Ser Arg Ile Ser Ile Thr Arg Asp Thr Ser Lys Asn Gln Phe Phe 
65                  70                  75                  80  


Leu Gln Leu Asn Ser Val Thr Thr Glu Asp Thr Ala Thr Tyr Tyr Cys 
                85                  90                  95      


Ala Arg Leu Trp Ser Trp Tyr Phe Asp Val Trp Gly Ala Gly Thr Thr 
            100                 105                 110         


Val Thr Val Ser Ser 
        115         


<210>  396
<211>  112
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic Anti TF variable light chain TF9

<400>  396

Asn Ile Met Met Thr Gln Ser Pro Ser Ser Leu Ala Val Ser Ala Gly 
1               5                   10                  15      


Glu Lys Val Thr Met Ser Cys Lys Ser Ser Gln Ser Val Leu Tyr Ser 
            20                  25                  30          


Ser Asn Gln Lys Asn Tyr Leu Ala Trp Tyr Gln Gln Lys Pro Gly Gln 
        35                  40                  45              


Ser Pro Lys Leu Leu Ile Tyr Trp Ala Ser Thr Arg Glu Ser Gly Val 
    50                  55                  60                  


Pro Asp Arg Phe Thr Gly Ser Gly Ser Gly Thr Asp Phe Thr Leu Thr 
65                  70                  75                  80  


Ile Ser Ser Val Gln Ala Glu Asp Leu Ala Val Tyr Tyr Cys His Gln 
                85                  90                  95      


Tyr Leu Ser Ser Tyr Thr Phe Gly Gly Gly Thr Lys Leu Glu Ile Lys 
            100                 105                 110         


<210>  397
<211>  5
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic Anti TF variable heavy chain CDR1 TF260

<400>  397

Ser Tyr Trp Ile Glu 
1               5   


<210>  398
<211>  17
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic Anti TF variable heavy chain CDR2 TF260

<400>  398

Glu Ile Leu Pro Gly Ser Gly Ser Thr Asn Tyr Asn Glu Lys Phe Lys 
1               5                   10                  15      


Gly 
    


<210>  399
<211>  8
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic Anti TF variable heavy chain CDR3 TF260

<400>  399

Glu Asp Arg Tyr Asp Gly Asp Tyr 
1               5               


<210>  400
<211>  14
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic Anti TF variable heavy chain CDR1 TF260

<400>  400

Arg Ser Ser Thr Gly Ala Val Thr Thr Ser Asn Tyr Ala Asn 
1               5                   10                  


<210>  401
<211>  7
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic Anti TF variable heavy chain CDR2 TF260

<400>  401

Gly Thr Asn Asn Arg Ala Pro 
1               5           


<210>  402
<211>  9
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic Anti TF variable heavy chain CDR3 TF260

<400>  402

Ala Leu Trp Tyr Ser Asn His Trp Val 
1               5                   


<210>  403
<211>  5
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic Anti TF variable heavy chain CDR1 TF196

<400>  403

Gly Tyr Asn Met Asn 
1               5   


<210>  404
<211>  17
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic Anti TF variable heavy chain CDR2 TF196

<400>  404

Asn Ile Asp Pro Tyr Tyr Gly Gly Thr Ser Tyr Asn Gln Lys Phe Lys 
1               5                   10                  15      


Gly 
    


<210>  405
<211>  8
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic Anti TF variable heavy chain CDR3 TF196

<400>  405

Asp Ser Ser Ser Trp Phe Ala Tyr 
1               5               


<210>  406
<211>  11
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic Anti TF variable heavy chain CDR1 TF196

<400>  406

Arg Ala Ser Gly Asn Ile His Asn Tyr Leu Ala 
1               5                   10      


<210>  407
<211>  7
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic Anti TF variable heavy chain CDR2 TF196

<400>  407

Asn Ala Lys Thr Leu Ala Asp 
1               5           


<210>  408
<211>  9
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic Anti TF variable heavy chain CDR3 TF196

<400>  408

Gln His Phe Trp Ile Thr Pro Trp Thr 
1               5                   


<210>  409
<211>  6
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic Anti TF variable heavy chain CDR1 TF9

<400>  409

Ser Gly Tyr Ser Trp His 
1               5       


<210>  410
<211>  16
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic Anti TF variable heavy chain CDR2 TF9

<400>  410

Tyr Ile His Tyr Ser Gly Ser Thr Lys Tyr Asn Pro Ser Leu Lys Ser 
1               5                   10                  15      


<210>  411
<211>  8
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic Anti TF variable heavy chain CDR3 TF9

<400>  411

Leu Trp Ser Trp Tyr Phe Asp Val 
1               5               


<210>  412
<211>  17
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic Anti TF variable heavy chain CDR1 TF9

<400>  412

Lys Ser Ser Gln Ser Val Leu Tyr Ser Ser Asn Gln Lys Asn Tyr Leu 
1               5                   10                  15      


Ala 
    


<210>  413
<211>  7
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic Anti TF variable heavy chain CDR2 TF9

<400>  413

Trp Ala Ser Thr Arg Glu Ser 
1               5           


<210>  414
<211>  8
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic Anti TF variable heavy chain CDR3 TF9

<400>  414

His Gln Tyr Leu Ser Ser Tyr Thr 
1               5               


<210>  415
<211>  118
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic Anti TF variable heavy chain

<400>  415

Glu Val Gln Leu Leu Glu Ser Gly Gly Gly Leu Val Gln Pro Gly Gly 
1               5                   10                  15      


Ser Leu Arg Leu Ser Cys Ala Ala Ser Gly Phe Thr Phe Ser Asn Tyr 
            20                  25                  30          


Ala Met Ser Trp Val Arg Gln Ala Pro Gly Lys Gly Leu Glu Trp Val 
        35                  40                  45              


Ser Ser Ile Ser Gly Ser Gly Asp Tyr Thr Tyr Tyr Thr Asp Ser Val 
    50                  55                  60                  


Lys Gly Arg Phe Thr Ile Ser Arg Asp Asn Ser Lys Asn Thr Leu Tyr 
65                  70                  75                  80  


Leu Gln Met Asn Ser Leu Arg Ala Glu Asp Thr Ala Val Tyr Tyr Cys 
                85                  90                  95      


Ala Arg Ser Pro Trp Gly Tyr Tyr Leu Asp Ser Trp Gly Gln Gly Thr 
            100                 105                 110         


Leu Val Thr Val Ser Ser 
        115             


<210>  416
<211>  107
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic Anti TF variable light chain

<400>  416

Asp Ile Gln Met Thr Gln Ser Pro Pro Ser Leu Ser Ala Ser Ala Gly 
1               5                   10                  15      


Asp Arg Val Thr Ile Thr Cys Arg Ala Ser Gln Gly Ile Ser Ser Arg 
            20                  25                  30          


Leu Ala Trp Tyr Gln Gln Lys Pro Glu Lys Ala Pro Lys Ser Leu Ile 
        35                  40                  45              


Tyr Ala Ala Ser Ser Leu Gln Ser Gly Val Pro Ser Arg Phe Ser Gly 
    50                  55                  60                  


Ser Gly Ser Gly Thr Asp Phe Thr Leu Thr Ile Ser Ser Leu Gln Pro 
65                  70                  75                  80  


Glu Asp Phe Ala Thr Tyr Tyr Cys Gln Gln Tyr Asn Ser Tyr Pro Tyr 
                85                  90                  95      


Thr Phe Gly Gln Gly Thr Lys Leu Glu Ile Lys 
            100                 105         


<210>  417
<211>  118
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic Anti TF variable heavy chain

<400>  417

Gln Val Gln Leu Val Gln Ser Gly Ala Glu Val Arg Lys Pro Gly Ser 
1               5                   10                  15      


Ser Val Lys Val Ser Cys Lys Ala Ser Gly Gly Ser Phe Asn Asn Tyr 
            20                  25                  30          


Pro Ile Phe Trp Val Arg Gln Ala Pro Gly Gln Gly Phe Glu Trp Met 
        35                  40                  45              


Gly Arg Ile Ile Pro Ile Leu Gly Ile Thr Ala Tyr Ala Gln Lys Phe 
    50                  55                  60                  


Gln Gly Arg Val Thr Ile Thr Ala Asp Lys Ser Thr Ser Thr Ala Tyr 
65                  70                  75                  80  


Met Glu Leu Asn Ser Leu Arg Ser Glu Asp Thr Ala Val Tyr Tyr Cys 
                85                  90                  95      


Ala Gly Gly Asp Asp Leu Asp Ala Phe Asp Ile Trp Gly Gln Gly Thr 
            100                 105                 110         


Met Val Ser Val Ser Ser 
        115             


<210>  418
<211>  107
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic Anti TF variable light chain

<400>  418

Asp Ile Gln Met Thr Gln Ser Pro Ser Ser Leu Ser Ala Ser Val Gly 
1               5                   10                  15      


Asp Arg Val Thr Ile Thr Cys Arg Ala Ser Gln Gly Ile Ser Ser Trp 
            20                  25                  30          


Leu Ala Trp Tyr Gln Gln Lys Pro Glu Lys Ala Pro Lys Ser Leu Ile 
        35                  40                  45              


Tyr Ala Ala Ser Ser Leu Gln Ser Gly Val Pro Ser Arg Phe Ser Gly 
    50                  55                  60                  


Ser Gly Ser Gly Thr Asp Phe Thr Leu Thr Ile Ser Ser Leu Gln Pro 
65                  70                  75                  80  


Glu Asp Phe Ala Thr Tyr Tyr Cys Gln Gln Tyr Asn Ser Tyr Pro Tyr 
                85                  90                  95      


Thr Phe Gly Gln Gly Thr Lys Leu Glu Ile Lys 
            100                 105         


<210>  419
<211>  120
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic Anti TF variable heavy chain

<400>  419

Gln Val Gln Leu Val Glu Ser Gly Gly Gly Val Val Gln Pro Gly Arg 
1               5                   10                  15      


Ser Leu Arg Leu Ser Cys Ala Gly Ser Gly Phe Thr Phe Asn Arg Tyr 
            20                  25                  30          


Ala Met Tyr Trp Val Arg Gln Ala Pro Gly Lys Gly Leu Asp Trp Val 
        35                  40                  45              


Ala Val Ile Ser Asn Asp Gly Ile Asn Lys Tyr Tyr Ala Asp Ser Val 
    50                  55                  60                  


Lys Gly Arg Phe Thr Ile Ser Arg Asp Asn Ser Lys Asn Thr Leu Tyr 
65                  70                  75                  80  


Leu Gln Met Asn Ser Leu Arg Ala Glu Asp Thr Ala Val Tyr Tyr Cys 
                85                  90                  95      


Ala Arg Asp His Thr Met Val Arg Gly Ala Phe Asp Tyr Trp Gly Gln 
            100                 105                 110         


Gly Thr Leu Val Thr Val Ser Ser 
        115                 120 


<210>  420
<211>  107
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic Anti TF variable light chain

<400>  420

Glu Ile Val Leu Thr Gln Ser Pro Ala Thr Leu Ser Leu Ser Pro Gly 
1               5                   10                  15      


Glu Arg Ala Thr Leu Ser Cys Arg Ala Ser Gln Ser Val Ser Ser Tyr 
            20                  25                  30          


Leu Ala Trp Tyr Gln Gln Lys Pro Gly Gln Ala Pro Arg Leu Leu Ile 
        35                  40                  45              


Tyr Asp Ala Ser Asn Arg Ala Thr Gly Ile Pro Ala Arg Phe Ser Gly 
    50                  55                  60                  


Ser Gly Ser Gly Thr Asp Phe Thr Leu Thr Ile Ser Ser Leu Glu Pro 
65                  70                  75                  80  


Glu Asp Phe Ala Val Tyr Tyr Cys Gln Gln Arg Ser Asn Trp Pro Leu 
                85                  90                  95      


Thr Phe Gly Gly Gly Thr Lys Val Glu Ile Lys 
            100                 105         


<210>  421
<211>  119
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic Anti TF variable heavy chain

<400>  421

Gln Val Gln Leu Val Glu Ser Gly Gly Gly Val Val Gln Pro Gly Arg 
1               5                   10                  15      


Ser Leu Arg Leu Ser Cys Val Ala Ser Gly Phe Thr Val Ser Asn Asp 
            20                  25                  30          


Gly Met His Trp Val Arg Gln Ala Pro Gly Lys Gly Leu Glu Trp Val 
        35                  40                  45              


Ala Leu Ile Trp Tyr Asp Gly Val Asn Lys Asn Tyr Ala Asp Ser Val 
    50                  55                  60                  


Lys Gly Arg Phe Thr Ile Ser Arg Asp Lys Ser Lys Asn Thr Leu Tyr 
65                  70                  75                  80  


Leu Gln Met Asn Ser Leu Arg Ala Glu Asp Thr Ala Val Tyr Tyr Cys 
                85                  90                  95      


Ala Arg Arg Pro Gly Thr Phe Tyr Gly Leu Asp Val Trp Gly Gln Gly 
            100                 105                 110         


Thr Thr Val Thr Val Ser Ser 
        115                 


<210>  422
<211>  107
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic Anti TF variable light chain

<400>  422

Glu Ile Val Leu Thr Gln Ser Pro Gly Thr Leu Ser Leu Ser Pro Gly 
1               5                   10                  15      


Glu Arg Ala Thr Leu Ser Cys Arg Ala Ser Gln Ser Val Ser Ser Ser 
            20                  25                  30          


Tyr Leu Ala Trp Tyr Gln Gln Lys Pro Gly Gln Ala Pro Arg Leu Leu 
        35                  40                  45              


Ile Tyr Gly Ala Ser Ser Arg Ala Thr Gly Ile Pro Asp Arg Phe Ser 
    50                  55                  60                  


Gly Ser Gly Ser Gly Thr Asp Phe Thr Leu Thr Ile Ser Arg Leu Glu 
65                  70                  75                  80  


Pro Glu Asp Phe Ala Val Tyr Tyr Cys Gln Gln Tyr Gly Ser Ser Leu 
                85                  90                  95      


Thr Phe Gly Gly Gly Thr Lys Val Glu Ile Lys 
            100                 105         


<210>  423
<211>  118
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic Anti TF variable heavy chain

<400>  423

Met Glu Ile Gln Leu Gln Gln Ser Gly Pro Glu Leu Val Lys Pro Gly 
1               5                   10                  15      


Ala Ser Val Gln Val Ser Cys Lys Thr Ser Gly Tyr Ser Phe Thr His 
            20                  25                  30          


Phe Asn Val Tyr Trp Val Arg Gln Ser His Gly Lys Ser Leu Glu Trp 
        35                  40                  45              


Ile Gly Tyr Ile Asp Pro Asp Asn Gly Ile Thr Phe Tyr Asp Glu Asn 
    50                  55                  60                  


Phe Met Gly Lys Ala Thr Leu Thr Val Asp Lys Ser Ser Thr Thr Ala 
65                  70                  75                  80  


Phe Met His Leu Asn Ser Leu Thr Ser Asp Asp Ser Ala Val Tyr Phe 
                85                  90                  95      


Cys Ala Arg Asp Val Thr Thr Ala Val Asp Phe Trp Gly Gln Gly Thr 
            100                 105                 110         


Thr Leu Thr Val Ser Ser 
        115             


<210>  424
<211>  107
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic Anti TF variable light chain

<400>  424

Asp Ile Gln Met Thr Gln Ser Pro Ala Ser Gln Ser Ala Ser Leu Gly 
1               5                   10                  15      


Glu Ser Val Thr Ile Thr Cys Leu Ala Thr Gln Thr Leu Asp Thr Trp 
            20                  25                  30          


Leu Ala Trp Tyr Gln Gln Lys Pro Gly Lys Ser Pro Gln Leu Leu Ile 
        35                  40                  45              


Tyr Ala Ala Thr Tyr Leu Ala Asp Gly Val Pro Ser Arg Phe Ser Gly 
    50                  55                  60                  


Ser Gly Ser Gly Thr Lys Phe Ser Phe Lys Ile Ser Ser Leu Gln Ala 
65                  70                  75                  80  


Glu Asp Phe Val Asn Tyr Tyr Cys Gln Leu Val Tyr Ser Ser Pro Ser 
                85                  90                  95      


Thr Phe Gly Ala Gly Thr Lys Leu Glu Leu Lys 
            100                 105         


<210>  425
<211>  350
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Synthetic Anti TF variable heavy chain TF260

<400>  425
caggtgcagc tgaagcagtc tggagctgag ctgatgaagc ctggggcctc agtgaagata       60

tcctgcaagg ctactggcta cacattcagt agctactgga tagagtgggt aaagcagagg      120

cctggacatg gccttgagtg gattggagag attttacctg gaagtggtag tactaactac      180

aatgagaagt tcaagggcaa ggccacattc actgcagata catcctccaa cacagcctac      240

atgcaactca gcagcctgac atctgaggac tctgccgtct attactgtgc aagagaggat      300

aggtacgacg gtgactactg gggccaaggc accactctca cagtctcgag                 350


<210>  426
<211>  337
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Synthetic Anti TF variable light chain TF260

<400>  426
caggctgttg tgactcagga atctgcactc accacatcac ctggtgaaac agtcacactc       60

acttgtcgct caagtactgg ggctgttaca actagtaact atgccaactg ggtccaagaa      120

aaaccagatc atttattcac tggtctaata ggtggtacca acaaccgagc tccaggtgtt      180

cctgccagat tctcaggctc cctgattgga gacaaggctg ccctcaccat cacaggggca      240

cagactgagg atgaggcaat atatttctgt gctctatggt acagcaacca ctgggtgttc      300

ggtggaggaa ccaaactgac tgtcctaggt cagcccc                               337


<210>  427
<211>  351
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Synthetic Anti TF variable heavy chain TF196

<400>  427
caggtgcagc tgaagcagtc tggacctgag ctggagaagc ctggcgcttc agtgaagata       60

tcctgcaagg cttctggtta ctcattcact ggctacaaca tgaactgggt gaagcagagc      120

aatggaaaga gccttgagtg gattggaaat attgatcctt actatggtgg tactagctac      180

aaccagaagt tcaagggcaa ggccacattg actgtagaca aatcctccaa cacagcctac      240

atgcacctca agagcctgac atctgaggac tctgcagtct attactgtgc aagagatagt      300

agctcctggt ttgcttactg gggccaaggg actctggtca ctgtctctgc a               351


<210>  428
<211>  325
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Synthetic Anti TF variable light chain TF196

<400>  428
gacatccagc tgactcagtc tccagcctcc ctatctgcat ctgtgggaga aactgtcacc       60

atcacatgtc gagcaagtgg gaatattcac aattatttag catggtatca gcagaaacag      120

ggaaaatctc ctcagctcct ggtctataat gcaaaaacct tagcagatgg tgtgccatca      180

aggttcagtg gcagtggatc aggaacacaa tattctctca agatcaacag cctgcagcct      240

gaagattttg ggagttatta ctgtcaacat ttttggatta ctccgtggac gttcggtgga      300

ggcaccaagc tggagatcta acgga                                            325


<210>  429
<211>  363
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Synthetic Anti TF variable heavy chain TF278

<400>  429
gaggtccagc tgcagcaatc tggagctgag ctgatgaagc ctggggcctc agtgaagata       60

tcctgcaagg ctactggcta cacattcagt agctactgga tagagtgggt aaagcagagg      120

cctggacatg gccttgagtg gattggagag attttacctg gaagtgctag tactaagtac      180

aatgagaagt tcaagggcaa ggccacattc actgcagata catcctccaa cacagcctac      240

atgcaactca gcagcctgac atctgaggac tctgccgtct attactgtgc aagagattat      300

tactacggta gtagctacgg gtttgcttac tggggccaag ggactctggt cactgtctcg      360

agt                                                                    363


<210>  430
<211>  330
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Synthetic Anti TF variable light chain TF278

<400>  430
caggctgttg tgactcagga atctgcactc accacatcac ctggtgaaac agtcacactc       60

acttgtcgct caagtactgg ggctgttaca actagtaact atgccaactg ggtccaagaa      120

aaaccagatc atttattcac tggcctaata ggtggtacca acaaccgagg tccaggtgtt      180

cctgccagat tctcaggctc cctgattgga gacaaggctg ccctcaccat cacaggggca      240

cagactgagg atgaggcagt atatttctgt gctctatggt acagcaacca ttgggtgttc      300

ggtggaggaa ccaaactgac tgtcctaggt                                       330


<210>  431
<211>  354
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Synthetic Anti TF variable heavy chain TF277

<400>  431
caggtccaac tgcagcagcc tggggctgag cttgtgaagc ctggggcttc agtgaagctg       60

tcctgcaaga cttctggcta caccttcacc agctactgga tgcactgggt gaagcagagg      120

cctggacaag gccttgagtg gatcggagag attgatcctt ctgatagtta tactaactac      180

aatcaaaagt tcaagggcaa ggccacattg actgtagaca aatcctccag cacagcctac      240

atgcagctca gcagcctgac atctgaggac tctgcggtct attactgtac ctactatgtt      300

aactactatg ctatggacta ctggggtcaa ggaacctcag tcaccgtctc ctca            354


<210>  432
<211>  318
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Synthetic Anti TF variable light chain TF277

<400>  432
caaattgttc tcacccagtc tccagcaatc atgtctgcat ctctagggga ggagatcacc       60

ctaacctgca gtgccagctc gagtgtaagt tacatgcact ggtaccagca gaagtcaggc      120

acttctccca aactcttgat ttatagcaca tccaacctgg cttctggagt cccttctcgc      180

ttcagtggca gtgggtctgg gaccttttat tctctcacaa tcagcagtgt ggaggctgaa      240

gatgctgccg attattactg ccatcagtgg agtagttatc catacacgtt cggagggggg      300

accaagctgg aaataaaa                                                    318


<210>  433
<211>  360
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Synthetic Anti TF variable heavy chain TF392

<400>  433
caggtgcagc tgaaggagtc tggagctgag ctgatgaagc ctggggcctc agtgaagata       60

tcctgcaagg ctactggcta cacattcagt agctactgga tagagtgggt aaagcagagg      120

cctggacatg gccttgagtg gattggagag attttacctg gaagtggtag tactaactac      180

aatgagaagt tcaagggcaa ggccacattc actgcagata catcctccaa cacagcctac      240

atgcaactca gcagcctgac atctgaggac tctgccgtct attactgtgc aagagacagg      300

aacggctacg tgaactactt tgactcctgg ggccaaggca ccactctcac agtctcctca      360


<210>  434
<211>  337
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Synthetic Anti TF variable light chain TF392

<400>  434
caggctgttg tgactcagga atctgcactc accacatcac ctggtgaaac agtcacactc       60

acttgtcgct caagtactgg ggctgttaca actagtaact atgccaactg ggtccaagaa      120

aaaccagatc atttattcac tggtctaata ggtggtacca acaaccgagc tccaggtgtt      180

cctgccagat tctcaggctc cctgattgga gacaaggctg ccctcaccat cacaggggca      240

cagactgagg atgaggcaat atatttctgt gctctatggt acagcaacca ctgggtgttc      300

ggtggaggaa ccaaactgac tgtcctaggt cagcccc                               337


<210>  435
<211>  351
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Synthetic Anti TF variable heavy chain TF9

<400>  435
gatgtgaagc ttcaggagtc aggacctgac ctggtgaaac cttctcagtc actttcactc       60

acctgcactg tcactggcta ctccatcacc agtggttata gctggcactg gatccggcag      120

tttccaggaa acaaactgga atggatgggc tacatacact acagtggtag cactaagtac      180

aacccatctc tcaaaagtcg aatctctatc actcgagaca catccaagaa ccagttcttc      240

ctgcagttga attctgtgac tactgaggac acagccacat attactgtgc aagactctgg      300

agttggtact tcgatgtctg gggcgcaggg accacggtca ccgtctcctc a               351


<210>  436
<211>  336
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Synthetic Anti TF variable light chain TF9

<400>  436
aacattatga tgacacagtc gccatcatct ctggctgtgt ctgcaggaga aaaggtcact       60

atgagctgta agtccagtca aagtgtttta tacagttcaa atcagaagaa ctacttggcc      120

tggtaccagc agaaaccagg gcagtctcct aaactgctga tctactgggc atccactagg      180

gaatctggtg tccctgatcg cttcacaggc agtggatctg ggacagattt tactcttacc      240

atcagcagtg tacaagctga agacctggca gtttattact gtcatcaata cctctcctcg      300

tacacgttcg gaggggggac caagctggaa ataaaa                                336


<210>  437
<211>  121
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic Anti LFA-1 variable heavy chain

<400>  437

Glu Val Gln Leu Val Glu Ser Gly Gly Gly Leu Val Gln Pro Gly Gly 
1               5                   10                  15      


Ser Leu Arg Leu Ser Cys Ala Ala Ser Gly Phe Thr Phe Ser Ser Phe 
            20                  25                  30          


Gly Met His Trp Val Arg Gln Ala Pro Gly Lys Gly Leu Glu Trp Val 
        35                  40                  45              


Ser Tyr Ile Ser Ser Gly Ser Ser Thr Leu His Tyr Ala Asp Thr Val 
    50                  55                  60                  


Lys Gly Arg Phe Thr Ile Ser Arg Asp Asn Ser Lys Asn Ser Leu Tyr 
65                  70                  75                  80  


Leu Gln Met Asn Ser Leu Arg Ala Glu Asp Thr Ala Val Tyr Tyr Cys 
                85                  90                  95      


Ala Arg Gly Ser Arg Asn Leu Ser His Arg Leu Leu Ser Tyr Trp Gly 
            100                 105                 110         


Gln Gly Thr Leu Val Thr Val Ser Ser 
        115                 120     


<210>  438
<211>  108
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic Anti LFA-1 variable light chain

<400>  438

Asp Ile Val Met Thr Gln Ser Pro Ser Leu Leu Ser Ala Ser Val Gly 
1               5                   10                  15      


Asp Arg Val Thr Ile Thr Cys Lys Ala Ser Gln Asp Val Ser Thr Ala 
            20                  25                  30          


Val Ala Trp Tyr Gln Gln Lys Pro Gly Lys Ala Pro Lys Leu Leu Ile 
        35                  40                  45              


Tyr Trp Ala Ser Thr Arg His Thr Gly Val Pro Ser Arg Phe Ser Gly 
    50                  55                  60                  


Ser Gly Ser Gly Thr Asp Phe Thr Leu Thr Ile Ser Ser Leu Gln Pro 
65                  70                  75                  80  


Glu Asp Phe Ala Leu Tyr Tyr Cys Gln Gln His Tyr Thr Thr Pro Trp 
                85                  90                  95      


Thr Phe Gly Gly Gly Thr Lys Val Glu Ile Lys Arg 
            100                 105             


<210>  439
<211>  121
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic Anti LFA-1 variable heavy chain

<400>  439

Glu Val Lys Leu Val Glu Ser Gly Gly Gly Leu Val Gln Pro Gly Gly 
1               5                   10                  15      


Ser Leu Arg Leu Ser Cys Ala Ala Ser Gly Phe Thr Phe Ser Ser Phe 
            20                  25                  30          


Gly Met His Trp Val Arg Gln Ala Pro Glu Lys Gly Leu Glu Trp Val 
        35                  40                  45              


Ala Tyr Ile Ser Ser Gly Ser Ser Thr Leu His Tyr Ala Asp Thr Val 
    50                  55                  60                  


Lys Gly Arg Phe Thr Ile Ser Arg Asp Asn Ser Lys Asn Ser Leu Tyr 
65                  70                  75                  80  


Leu Gln Met Asn Leu Leu Arg Ala Glu Asp Thr Ala Val Tyr Tyr Cys 
                85                  90                  95      


Ala Arg Gly Ser Arg Asn Leu Ser His Arg Leu Leu Ser Tyr Trp Gly 
            100                 105                 110         


Gln Gly Thr Leu Val Thr Val Ser Ser 
        115                 120     


<210>  440
<211>  108
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic Anti LFA-1 variable light chain

<400>  440

Asp Ile Leu Met Thr Gln Ser Pro Ser Leu Leu Ser Ala Ser Val Gly 
1               5                   10                  15      


Asp Arg Val Thr Ile Thr Cys Lys Ala Ser Gln Asp Val Ser Thr Ala 
            20                  25                  30          


Val Ala Trp Tyr Gln Gln Lys Pro Gly Lys Ala Pro Lys Leu Leu Ile 
        35                  40                  45              


Tyr Trp Ala Ser Thr Arg His Thr Gly Val Pro Ser Arg Phe Thr Gly 
    50                  55                  60                  


Ser Gly Ser Gly Thr Asp Phe Thr Leu Thr Ile Ser Arg Leu Gln Ala 
65                  70                  75                  80  


Glu Asp Phe Ala Leu Tyr Tyr Cys Gln Gln His Tyr Thr Thr Pro Trp 
                85                  90                  95      


Thr Phe Gly Gly Gly Thr Lys Val Glu Ile Lys Arg 
            100                 105             


<210>  441
<211>  5
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic Anti LFA-1 variable heavy chain CDR1

<400>  441

Ser Phe Gly Met His 
1               5   


<210>  442
<211>  17
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic Anti LFA-1 variable heavy chain CDR2

<400>  442

Tyr Ile Ser Ser Gly Ser Ser Thr Leu His Tyr Ala Asp Thr Val Lys 
1               5                   10                  15      


Gly 
    


<210>  443
<211>  11
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic Anti LFA-1 variable heavy chain CDR3

<400>  443

Gly Ser Arg Asn Leu Ser His Arg Leu Leu Ser 
1               5                   10      


<210>  444
<211>  11
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic Anti LFA-1 variable heavy chain CDR1

<400>  444

Lys Ala Ser Gln Asp Val Ser Thr Ala Val Ala 
1               5                   10      


<210>  445
<211>  7
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic Anti LFA-1 variable heavy chain CDR2

<400>  445

Trp Ala Ser Thr Arg His Thr 
1               5           


<210>  446
<211>  9
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic Anti LFA-1 variable heavy chain CDR3

<400>  446

Gln Gln His Tyr Thr Thr Pro Trp Thr 
1               5                   


<210>  447
<211>  252
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic Anti FAP scFv

<400>  447

Asp Ile Val Met Thr Gln Ser Pro Asp Ser Leu Ala Val Ser Leu Gly 
1               5                   10                  15      


Glu Arg Ala Thr Ile Asn Cys Lys Ser Ser Gln Ser Leu Leu Tyr Ser 
            20                  25                  30          


Arg Asn Gln Lys Asn Tyr Leu Ala Trp Tyr Gln Gln Lys Pro Gly Gln 
        35                  40                  45              


Pro Pro Lys Leu Leu Ile Phe Trp Ala Ser Thr Arg Glu Ser Gly Val 
    50                  55                  60                  


Pro Asp Arg Phe Ser Gly Ser Gly Phe Gly Thr Asp Phe Thr Leu Thr 
65                  70                  75                  80  


Ile Ser Ser Leu Gln Ala Glu Asp Val Ala Val Tyr Tyr Cys Gln Gln 
                85                  90                  95      


Tyr Phe Ser Tyr Pro Leu Thr Phe Gly Gln Gly Thr Lys Val Glu Ile 
            100                 105                 110         


Lys Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser 
        115                 120                 125             


Gln Val Gln Leu Val Gln Ser Gly Ala Glu Val Lys Lys Pro Gly Ala 
    130                 135                 140                 


Ser Val Lys Val Ser Cys Lys Thr Ser Arg Tyr Thr Phe Thr Glu Tyr 
145                 150                 155                 160 


Thr Ile His Trp Val Arg Gln Ala Pro Gly Gln Arg Leu Glu Trp Ile 
                165                 170                 175     


Gly Gly Ile Asn Pro Asn Asn Gly Ile Pro Asn Tyr Asn Gln Lys Phe 
            180                 185                 190         


Lys Gly Arg Val Thr Ile Thr Val Asp Thr Ser Ala Ser Thr Ala Tyr 
        195                 200                 205             


Met Glu Leu Ser Ser Leu Arg Ser Glu Asp Thr Ala Val Tyr Tyr Cys 
    210                 215                 220                 


Ala Arg Arg Arg Ile Ala Tyr Gly Tyr Asp Glu Gly His Ala Met Asp 
225                 230                 235                 240 


Tyr Trp Gly Gln Gly Thr Leu Val Thr Val Ser Ser 
                245                 250         


<210>  448
<211>  124
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic Anti FAP sibrotuzumab variable heavy chain

<400>  448

Gln Val Gln Leu Val Gln Ser Gly Ala Glu Val Lys Lys Pro Gly Ala 
1               5                   10                  15      


Ser Val Lys Val Ser Cys Lys Thr Ser Arg Tyr Thr Phe Thr Glu Tyr 
            20                  25                  30          


Thr Ile His Trp Val Arg Gln Ala Pro Gly Gln Arg Leu Glu Trp Ile 
        35                  40                  45              


Gly Gly Ile Asn Pro Asn Asn Gly Ile Pro Asn Tyr Asn Gln Lys Phe 
    50                  55                  60                  


Lys Gly Arg Val Thr Ile Thr Val Asp Thr Ser Ala Ser Thr Ala Tyr 
65                  70                  75                  80  


Met Glu Leu Ser Ser Leu Arg Ser Glu Asp Thr Ala Val Tyr Tyr Cys 
                85                  90                  95      


Ala Arg Arg Arg Ile Ala Tyr Gly Tyr Asp Glu Gly His Ala Met Asp 
            100                 105                 110         


Tyr Trp Gly Gln Gly Thr Leu Val Thr Val Ser Ser 
        115                 120                 


<210>  449
<211>  113
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic Anti FAP sibrotuzumab variable light chain

<400>  449

Asp Ile Val Met Thr Gln Ser Pro Asp Ser Leu Ala Val Ser Leu Gly 
1               5                   10                  15      


Glu Arg Ala Thr Ile Asn Cys Lys Ser Ser Gln Ser Leu Leu Tyr Ser 
            20                  25                  30          


Arg Asn Gln Lys Asn Tyr Leu Ala Trp Tyr Gln Gln Lys Pro Gly Gln 
        35                  40                  45              


Pro Pro Lys Leu Leu Ile Phe Trp Ala Ser Thr Arg Glu Ser Gly Val 
    50                  55                  60                  


Pro Asp Arg Phe Ser Gly Ser Gly Phe Gly Thr Asp Phe Thr Leu Thr 
65                  70                  75                  80  


Ile Ser Ser Leu Gln Ala Glu Asp Val Ala Val Tyr Tyr Cys Gln Gln 
                85                  90                  95      


Tyr Phe Ser Tyr Pro Leu Thr Phe Gly Gln Gly Thr Lys Val Glu Ile 
            100                 105                 110         


Lys 
    


<210>  450
<211>  117
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic Anti FAP FAP5 variable heavy chain

<400>  450

Gln Val Gln Leu Gln Gln Ser Gly Ala Glu Leu Ala Arg Pro Gly Ala 
1               5                   10                  15      


Ser Val Asn Leu Ser Cys Lys Ala Ser Gly Tyr Thr Phe Thr Asn Asn 
            20                  25                  30          


Gly Ile Asn Trp Leu Lys Gln Arg Thr Gly Gln Gly Leu Glu Trp Ile 
        35                  40                  45              


Gly Glu Ile Tyr Pro Arg Ser Thr Asn Thr Leu Tyr Asn Glu Lys Phe 
    50                  55                  60                  


Lys Gly Lys Ala Thr Leu Thr Ala Asp Arg Ser Ser Asn Thr Ala Tyr 
65                  70                  75                  80  


Met Glu Leu Arg Ser Leu Thr Ser Glu Asp Ser Ala Val Tyr Phe Cys 
                85                  90                  95      


Ala Arg Thr Leu Thr Ala Pro Phe Ala Phe Trp Gly Gln Gly Thr Leu 
            100                 105                 110         


Val Thr Val Ser Ala 
        115         


<210>  451
<211>  107
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic Anti FAP FAP5 variable light chain

<400>  451

Gln Ile Val Leu Thr Gln Ser Pro Ala Ile Met Ser Ala Ser Pro Gly 
1               5                   10                  15      


Glu Lys Val Thr Met Thr Cys Ser Ala Ser Ser Gly Val Asn Phe Met 
            20                  25                  30          


His Trp Tyr Gln Gln Lys Ser Gly Thr Ser Pro Lys Arg Trp Ile Phe 
        35                  40                  45              


Asp Thr Ser Lys Leu Ala Ser Gly Val Pro Ala Arg Phe Ser Gly Ser 
    50                  55                  60                  


Gly Ser Gly Thr Ser Tyr Ser Leu Thr Ile Ser Ser Met Glu Ala Glu 
65                  70                  75                  80  


Asp Ala Ala Thr Tyr Tyr Cys Gln Gln Trp Ser Phe Asn Pro Pro Thr 
                85                  90                  95      


Phe Gly Gly Gly Thr Lys Leu Glu Ile Lys Arg 
            100                 105         


<210>  452
<211>  372
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Synthetic Anti FAP sibrotuzumab variable heavy chain

<400>  452
caggtgcaac tagtgcagtc cggcgccgaa gtgaagaaac ccggtgcttc cgtgaaagtc       60

agctgtaaaa ctagtagata caccttcact gaatacacca tacactgggt tagacaggcc      120

cctggccaaa ggctggagtg gataggaggt attaatccta acaatggtat tcctaactac      180

aaccagaagt tcaagggccg ggtcaccatc accgtagaca cctctgccag caccgcctac      240

atggaactgt ccagcctgcg ctccgaggac actgcagtct actactgcgc cagaagaaga      300

atcgcctatg gttacgacga gggccatgct atggactact ggggtcaagg aacccttgtc      360

accgtctcct ca                                                          372


<210>  453
<211>  339
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Synthetic Anti FAP sibrotuzumab variable light chain

<400>  453
gacattgtga tgacccaatc tccagactct ttggctgtgt ctctagggga gagggccacc       60

atcaactgca agtccagtca gagcctttta tattctagaa atcaaaagaa ctacttggcc      120

tggtatcagc agaaaccagg acagccaccc aaactcctca tcttttgggc tagcactagg      180

gaatctgggg tacctgatag gttcagtggc agtgggtttg ggacagactt caccctcacc      240

attagcagcc tgcaggctga agatgtggca gtttattact gtcagcaata ttttagctat      300

ccgctcacgt tcggacaagg gaccaaggtg gaaataaaa                             339


<210>  454
<211>  121
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic Anti VISTA antibody 1B8 variable heavy chain

<400>  454

Gln Met Gln Leu Val Gln Ser Gly Ala Glu Val Lys Lys Pro Gly Ser 
1               5                   10                  15      


Ser Val Lys Val Ser Cys Lys Ala Ser Gly Gly Ser Ser Ser Asn Tyr 
            20                  25                  30          


Ala Ile Ser Trp Val Arg Gln Ala Pro Gly Gln Gly Leu Glu Trp Met 
        35                  40                  45              


Gly Gly Ile Ile Pro Ile Phe Gly Thr Thr Ser Tyr Ala Gln Lys Phe 
    50                  55                  60                  


Gln Gly Arg Val Thr Ile Thr Ala Asp Gly Ser Met Ser Thr Ala Tyr 
65                  70                  75                  80  


Met Glu Leu Ser Ser Leu Arg Ser Glu Asp Thr Ala Val Tyr Tyr Cys 
                85                  90                  95      


Ala Lys Gly Ala Ile Glu Pro Trp Pro Phe Tyr Phe Asp Asn Trp Gly 
            100                 105                 110         


Gln Gly Thr Leu Val Thr Val Ser Ser 
        115                 120     


<210>  455
<211>  112
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic Anti VISTA antibody 1B8 variable heavy chain

<400>  455

Gln Leu Val Leu Thr Gln Pro Arg Ser Val Ser Gly Ser Pro Gly Gln 
1               5                   10                  15      


Ser Val Thr Ile Ser Cys Thr Gly Thr Asn Ser Asp Val Gly Ala Tyr 
            20                  25                  30          


Asn Tyr Leu Ser Trp Tyr Gln Gln Leu Pro Gly Arg Ala Pro Lys Val 
        35                  40                  45              


Ile Ile Tyr Asp Val Asn Lys Arg Pro Ser Gly Val Pro Asp Arg Phe 
    50                  55                  60                  


Ser Gly Ser Arg Ser Gly Lys Thr Ala Ser Leu Thr Ile Ser Gly Leu 
65                  70                  75                  80  


Gln Ala Glu Asp Glu Ala Asp Tyr Tyr Cys Ala Ala Trp Asp Asp Ser 
                85                  90                  95      


Leu Asn Gly Leu Val Phe Gly Gly Gly Thr Lys Leu Thr Val Leu Gly 
            100                 105                 110         


<210>  456
<211>  8
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic Anti VISTA antibody 1B8 variable heavy chain CDR1

<400>  456

Gly Gly Ser Ser Ser Asn Tyr Ala 
1               5               


<210>  457
<211>  8
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic Anti VISTA antibody 1B8 variable heavy chain CDR2

<400>  457

Ile Ile Pro Ile Phe Gly Thr Thr 
1               5               


<210>  458
<211>  14
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic Anti VISTA antibody 1B8 variable heavy chain CDR3

<400>  458

Ala Lys Gly Ala Ile Glu Pro Trp Pro Phe Tyr Phe Asp Asn 
1               5                   10                  


<210>  459
<211>  9
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic Anti VISTA antibody 1B8 variable light chain CDR1

<400>  459

Asn Ser Asp Val Gly Ala Tyr Asn Tyr 
1               5                   


<210>  460
<211>  3
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic Anti VISTA antibody 1B8 variable light chain CDR2

<400>  460

Asp Val Asn 
1           


<210>  461
<211>  11
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic Anti VISTA antibody 1B8 variable light chain CDR3

<400>  461

Ala Ala Trp Asp Asp Ser Leu Asn Gly Leu Val 
1               5                   10      


<210>  462
<211>  121
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic Anti VISTA antibody 2C12 variable heavy chain

<400>  462

Gln Val Gln Leu Val Glu Ser Gly Ala Glu Val Lys Lys Pro Gly Ala 
1               5                   10                  15      


Ser Val Lys Val Ser Cys Lys Ala Ser Gly Tyr Ile Phe Thr Asp Tyr 
            20                  25                  30          


Tyr Met His Trp Val Arg Gln Ala Pro Gly Gln Gly Leu Glu Trp Met 
        35                  40                  45              


Gly Val Ile Asn Pro Tyr Asp Gly Arg Thr Ser Phe Ala Gln Lys Phe 
    50                  55                  60                  


Gln Gly Arg Leu Thr Val Thr Arg Asp Thr Ser Thr Ser Thr Ala Tyr 
65                  70                  75                  80  


Met Asp Leu Ser Gly Leu Arg Ser Glu Asp Thr Ala Val Tyr Tyr Cys 
                85                  90                  95      


Ala Lys Gln Met Gly Ile Trp Asp Tyr Asp Ala Phe Asp Ile Trp Gly 
            100                 105                 110         


Gln Gly Thr Met Val Thr Val Ser Ser 
        115                 120     


<210>  463
<211>  112
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic Anti VISTA antibody 2C12 variable heavy chain

<400>  463

Gln Phe Val Leu Thr Gln Pro Ser Ser Val Ser Gly Ala Pro Gly Gln 
1               5                   10                  15      


Arg Val Ile Ile Ser Cys Thr Gly Ser Ser Ser Asn Ile Gly Ala Gly 
            20                  25                  30          


Tyr Asp Val His Trp Tyr Gln Gln Leu Pro Gly Thr Ala Pro Lys Val 
        35                  40                  45              


Leu Ile Tyr Gly Asn Ser Asp Arg Pro Ser Gly Val Pro Asp Arg Phe 
    50                  55                  60                  


Ser Ala Ser Lys Ser Ala Thr Ser Ala Ser Leu Ala Ile Thr Gly Leu 
65                  70                  75                  80  


Gln Ala Glu Asp Glu Ala Asp Tyr Tyr Cys Val Ala Trp Asp Asp Ser 
                85                  90                  95      


Leu Lys Ala Tyr Val Phe Gly Thr Gly Thr Lys Val Thr Val Leu Gly 
            100                 105                 110         


<210>  464
<211>  8
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic Anti VISTA antibody 2C12 variable heavy chain CDR1

<400>  464

Gly Tyr Ile Phe Thr Asp Tyr Tyr 
1               5               


<210>  465
<211>  8
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic Anti VISTA antibody 2C12 variable heavy chain CDR2

<400>  465

Ile Asn Pro Tyr Asp Gly Arg Thr 
1               5               


<210>  466
<211>  14
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic Anti VISTA antibody 2C12 variable heavy chain CDR3

<400>  466

Ala Lys Gln Met Gly Ile Trp Asp Tyr Asp Ala Phe Asp Ile 
1               5                   10                  


<210>  467
<211>  9
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic Anti VISTA antibody 2C12 variable light chain CDR1

<400>  467

Ser Ser Asn Ile Gly Ala Gly Tyr Asp 
1               5                   


<210>  468
<211>  3
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic Anti VISTA antibody 2C12 variable light chain CDR2

<400>  468

Gly Asn Ser 
1           


<210>  469
<211>  11
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic Anti VISTA antibody 2C12 variable light chain CDR3

<400>  469

Val Ala Trp Asp Asp Ser Leu Lys Ala Tyr Val 
1               5                   10      


<210>  470
<211>  122
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic Anti VISTA antibody 1A12 variable heavy chain

<400>  470

Gln Met Gln Leu Val Glu Ser Gly Gly Gly Leu Val Glu Pro Gly Arg 
1               5                   10                  15      


Ser Leu Arg Leu Ser Cys Thr Thr Ser Gly Phe Ser Phe His Asp Tyr 
            20                  25                  30          


Thr Met Tyr Trp Val Arg Gln Val Pro Gly Lys Gly Leu Glu Trp Val 
        35                  40                  45              


Ser Leu Ile Ser Trp Asp Gly Thr Ile Thr Phe Tyr Ala Asp Pro Val 
    50                  55                  60                  


Arg Gly Arg Phe Thr Ile Ser Arg Asp Asn Ser Lys Asn Ser Leu Tyr 
65                  70                  75                  80  


Leu Gln Met Asn Ser Leu Arg Ala Glu Asp Thr Ala Val Tyr Tyr Cys 
                85                  90                  95      


Ala Lys Glu Asp Arg Tyr Asp Tyr Tyr Ser Gly Ala Phe Asp Ile Trp 
            100                 105                 110         


Gly Gln Gly Thr Val Val Thr Val Ser Ser 
        115                 120         


<210>  471
<211>  112
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic Anti VISTA antibody 1A12 variable heavy chain

<400>  471

Gln Ser Ala Leu Thr Gln Pro Arg Ser Val Ser Gly Ser Pro Gly Gln 
1               5                   10                  15      


Ser Val Thr Ile Ser Cys Thr Gly Thr Ser Ser Asp Val Gly Gly Tyr 
            20                  25                  30          


Asp Tyr Val Ser Trp Tyr Gln Gln His Pro Gly Lys Ala Pro Lys Leu 
        35                  40                  45              


Ile Leu Asn Asp Val Asn Lys Arg Pro Ser Gly Val Pro Asp Arg Phe 
    50                  55                  60                  


Ser Gly Ser Lys Ser Gly Asn Thr Ala Ser Leu Thr Ile Ser Gly Leu 
65                  70                  75                  80  


Gln Pro Asp Asp Glu Ala Asp Tyr Tyr Cys Ser Ser Phe Ala Gly Ser 
                85                  90                  95      


Asn Thr Leu Arg Val Phe Gly Gly Gly Thr Lys Leu Thr Val Leu Gly 
            100                 105                 110         


<210>  472
<211>  8
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic Anti VISTA antibody 1A12 variable heavy chain CDR1

<400>  472

Gly Phe Ser Phe His Asp Tyr Thr 
1               5               


<210>  473
<211>  8
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic Anti VISTA antibody 1A12 variable heavy chain CDR2

<400>  473

Ile Ser Trp Asp Gly Thr Ile Thr 
1               5               


<210>  474
<211>  15
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic Anti VISTA antibody 1A12 variable heavy chain CDR3

<400>  474

Ala Lys Glu Asp Arg Tyr Asp Tyr Tyr Ser Gly Ala Phe Asp Ile 
1               5                   10                  15  


<210>  475
<211>  9
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic Anti VISTA antibody 1A12 variable light chain CDR1

<400>  475

Ser Ser Asp Val Gly Gly Tyr Asp Tyr 
1               5                   


<210>  476
<211>  3
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic Anti VISTA antibody 1A12 variable light chain CDR2

<400>  476

Asp Val Asn 
1           


<210>  477
<211>  11
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic Anti VISTA antibody 1A12 variable light chain CDR3

<400>  477

Ser Ser Phe Ala Gly Ser Asn Thr Leu Arg Val 
1               5                   10      


<210>  478
<211>  124
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic Anti VISTA antibody 3C5 variable heavy chain

<400>  478

Gln Val Gln Leu Val Gln Ser Gly Ala Glu Val Lys Lys Pro Gly Ala 
1               5                   10                  15      


Ser Val Lys Leu Ser Cys Lys Ala Ser Gly Tyr Thr Phe Ser Ser Tyr 
            20                  25                  30          


Trp Met His Trp Val Arg Gln Ala Pro Gly Gln Arg Leu Glu Trp Met 
        35                  40                  45              


Gly Glu Ile Asn Pro Gly Asn Gly His Thr Asn Tyr Asn Glu Lys Phe 
    50                  55                  60                  


Lys Ser Arg Val Thr Ile Thr Val Asp Lys Ser Ala Ser Thr Ala Tyr 
65                  70                  75                  80  


Met Glu Leu Ser Ser Leu Arg Ser Glu Asp Thr Ala Val Tyr Tyr Cys 
                85                  90                  95      


Ala Lys Asp Ile Ala Tyr Tyr Asp Phe Trp Ser Gly Asp Ala Phe Asp 
            100                 105                 110         


Leu Trp Gly Gln Gly Thr Met Val Thr Val Ser Ser 
        115                 120                 


<210>  479
<211>  107
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic Anti VISTA antibody 3C5 variable heavy chain

<400>  479

Ser Tyr Glu Leu Thr Gln Pro Leu Ser Val Ser Val Ser Pro Gly Gln 
1               5                   10                  15      


Thr Ala Ser Ile Thr Cys Ser Gly Asp Lys Leu Gly Asn Lys Tyr Ala 
            20                  25                  30          


Ser Trp Tyr Gln Gln Lys Pro Gly Gln Ser Pro Val Leu Val Ile Tyr 
        35                  40                  45              


Gln Asp Asn Lys Arg Pro Ser Gly Ile Pro Glu Arg Phe Ser Gly Ser 
    50                  55                  60                  


Asn Ser Gly Asn Thr Ala Thr Leu Thr Ile Ser Gly Thr Gln Ala Thr 
65                  70                  75                  80  


Asp Glu Ala Asp Tyr Tyr Cys Gln Thr Trp Asp Arg Ser Thr Gly Val 
                85                  90                  95      


Phe Gly Thr Gly Thr Lys Val Thr Val Leu Gly 
            100                 105         


<210>  480
<211>  8
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic Anti VISTA antibody 3C5 variable heavy chain CDR1

<400>  480

Gly Tyr Thr Phe Ser Ser Tyr Trp 
1               5               


<210>  481
<211>  8
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic Anti VISTA antibody 3C5 variable heavy chain CDR2

<400>  481

Ile Asn Pro Gly Asn Gly His Thr 
1               5               


<210>  482
<211>  17
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic Anti VISTA antibody 3C5 variable heavy chain CDR3

<400>  482

Ala Lys Asp Ile Ala Tyr Tyr Asp Phe Trp Ser Gly Asp Ala Phe Asp 
1               5                   10                  15      


Leu 
    


<210>  483
<211>  6
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic Anti VISTA antibody 3C5 variable light chain CDR1

<400>  483

Lys Leu Gly Asn Lys Tyr 
1               5       


<210>  484
<211>  3
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic Anti VISTA antibody 3C5 variable light chain CDR2

<400>  484

Gln Asp Asn 
1           


<210>  485
<211>  9
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic Anti VISTA antibody 3C5 variable light chain CDR3

<400>  485

Gln Thr Trp Asp Arg Ser Thr Gly Val 
1               5                   


<210>  486
<211>  120
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic Anti LRRC15 huM25 variable heavy chain

<400>  486

Glu Val Gln Leu Val Gln Ser Gly Ala Glu Val Lys Lys Pro Gly Ala 
1               5                   10                  15      


Ser Val Lys Val Ser Cys Lys Ala Ser Gly Tyr Lys Phe Ser Ser Tyr 
            20                  25                  30          


Trp Ile Glu Trp Val Lys Gln Ala Pro Gly Gln Gly Leu Glu Trp Ile 
        35                  40                  45              


Gly Glu Ile Leu Pro Gly Ser Asp Thr Thr Asn Tyr Asn Glu Lys Phe 
    50                  55                  60                  


Lys Asp Arg Ala Thr Phe Thr Ser Asp Thr Ser Ile Asn Thr Ala Tyr 
65                  70                  75                  80  


Met Glu Leu Ser Arg Leu Arg Ser Asp Asp Thr Ala Val Tyr Tyr Cys 
                85                  90                  95      


Ala Arg Asp Arg Gly Asn Tyr Arg Ala Trp Phe Gly Tyr Trp Gly Gln 
            100                 105                 110         


Gly Thr Leu Val Thr Val Ser Ser 
        115                 120 


<210>  487
<211>  107
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic Anti LRRC15 huM25 variable light chain

<400>  487

Asp Ile Gln Met Thr Gln Ser Pro Ser Ser Leu Ser Ala Ser Val Gly 
1               5                   10                  15      


Asp Arg Val Thr Ile Thr Cys Arg Ala Ser Gln Asp Ile Ser Asn Tyr 
            20                  25                  30          


Leu Asn Trp Tyr Gln Gln Lys Pro Gly Gly Ala Val Lys Phe Leu Ile 
        35                  40                  45              


Tyr Tyr Thr Ser Arg Leu His Ser Gly Val Pro Ser Arg Phe Ser Gly 
    50                  55                  60                  


Ser Gly Ser Gly Thr Asp Tyr Thr Leu Thr Ile Ser Ser Leu Gln Pro 
65                  70                  75                  80  


Glu Asp Phe Ala Thr Tyr Phe Cys Gln Gln Gly Glu Ala Leu Pro Trp 
                85                  90                  95      


Thr Phe Gly Gly Gly Thr Lys Val Glu Ile Lys 
            100                 105         


<210>  488
<211>  5
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic Anti LRRC15 antibody huM25 variable heavy chain CDR1

<400>  488

Ser Tyr Trp Ile Glu 
1               5   


<210>  489
<211>  17
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic Anti LRRC15 antibody huM25 variable heavy chain CDR2

<400>  489

Glu Ile Leu Pro Gly Ser Asp Thr Thr Asn Tyr Asn Glu Lys Phe Lys 
1               5                   10                  15      


Asp 
    


<210>  490
<211>  11
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic Anti LRRC15 antibody huM25 variable heavy chain CDR3

<400>  490

Asp Arg Gly Asn Tyr Arg Ala Trp Phe Gly Tyr 
1               5                   10      


<210>  491
<211>  11
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic Anti LRRC15 antibody huM25 variable light chain CDR1

<400>  491

Arg Ala Ser Gln Asp Ile Ser Asn Tyr Leu Asn 
1               5                   10      


<210>  492
<211>  7
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic Anti LRRC15 antibody huM25 variable light chain CDR2

<400>  492

Tyr Thr Ser Arg Leu His Ser 
1               5           


<210>  493
<211>  9
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic Anti LRRC15 antibody huM25 variable light chain CDR3

<400>  493

Gln Gln Gly Glu Ala Leu Pro Trp Thr 
1               5                   


<210>  494
<211>  119
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic Anti LRRC15  huAD208.4.1 variable heavy chain

<400>  494

Glu Val Gln Leu Val Gln Ser Gly Ala Glu Val Lys Lys Pro Gly Ser 
1               5                   10                  15      


Ser Val Lys Val Ser Cys Lys Ala Ser Gly Phe Thr Phe Thr Asp Tyr 
            20                  25                  30          


Tyr Ile His Trp Val Lys Gln Ala Pro Gly Gln Gly Leu Glu Trp Ile 
        35                  40                  45              


Gly Leu Val Tyr Pro Tyr Ile Gly Gly Thr Asn Tyr Asn Gln Lys Phe 
    50                  55                  60                  


Lys Gly Lys Ala Thr Leu Thr Val Asp Thr Ser Thr Thr Thr Ala Tyr 
65                  70                  75                  80  


Met Glu Met Ser Ser Leu Arg Ser Glu Asp Thr Ala Val Tyr Tyr Cys 
                85                  90                  95      


Ala Arg Gly Asp Asn Lys Tyr Asp Ala Met Asp Tyr Trp Gly Gln Gly 
            100                 105                 110         


Thr Thr Val Thr Val Ser Ser 
        115                 


<210>  495
<211>  110
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic Anti LRRC15 huAD208.4.1 variable light chain

<400>  495

Asp Ile Val Leu Thr Gln Ser Pro Asp Ser Leu Ala Val Ser Leu Gly 
1               5                   10                  15      


Glu Arg Ala Thr Ile Asn Cys Arg Ala Ser Gln Ser Val Ser Thr Ser 
            20                  25                  30          


Ser Tyr Ser Tyr Met His Trp Tyr Gln Gln Lys Pro Gly Gln Pro Pro 
        35                  40                  45              


Lys Leu Leu Ile Lys Tyr Ala Ser Ser Leu Glu Ser Gly Val Pro Asp 
    50                  55                  60                  


Arg Phe Ser Gly Ser Gly Ser Gly Thr Asp Phe Thr Leu Thr Ile Ser 
65                  70                  75                  80  


Ser Leu Gln Ala Glu Asp Val Ala Val Tyr Tyr Cys Glu Gln Ser Trp 
                85                  90                  95      


Glu Ile Arg Thr Phe Gly Gly Gly Thr Lys Val Glu Ile Lys 
            100                 105                 110 


<210>  496
<211>  5
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic Anti LRRC15 antibody huAD208.4.1 variable heavy chain 
       CDR1

<400>  496

Asp Tyr Tyr Ile His 
1               5   


<210>  497
<211>  17
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic Anti LRRC15 antibody huAD208.4.1 variable heavy chain 
       CDR2

<400>  497

Leu Val Tyr Pro Tyr Ile Gly Gly Thr Asn Tyr Asn Gln Lys Phe Lys 
1               5                   10                  15      


Gly 
    


<210>  498
<211>  10
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic Anti LRRC15 antibody huAD208.4.1 variable heavy chain 
       CDR3

<400>  498

Gly Asp Asn Lys Tyr Asp Ala Met Asp Tyr 
1               5                   10  


<210>  499
<211>  15
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic Anti LRRC15 antibody huAD208.4.1 variable light chain 
       CDR1

<400>  499

Arg Ala Ser Gln Ser Val Ser Thr Ser Ser Tyr Ser Tyr Met His 
1               5                   10                  15  


<210>  500
<211>  7
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic Anti LRRC15 antibody huAD208.4.1 variable light chain 
       CDR2

<400>  500

Tyr Ala Ser Ser Leu Glu Ser 
1               5           


<210>  501
<211>  8
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic amino acid

<400>  501

Glu Gln Ser Trp Glu Ile Arg Thr 
1               5               


<210>  502
<211>  121
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic amino acid

<400>  502

Glu Val Gln Leu Val Gln Ser Gly Ala Glu Val Lys Lys Pro Gly Ser 
1               5                   10                  15      


Ser Val Lys Val Ser Cys Lys Ala Ser Gly Tyr Thr Phe Thr Asn Tyr 
            20                  25                  30          


Trp Met His Trp Val Lys Gln Ala Pro Gly Gln Gly Leu Glu Trp Ile 
        35                  40                  45              


Gly Met Ile His Pro Asn Ser Gly Ser Thr Lys His Asn Glu Lys Phe 
    50                  55                  60                  


Arg Gly Lys Ala Thr Leu Thr Val Asp Glu Ser Thr Thr Thr Ala Tyr 
65                  70                  75                  80  


Met Glu Leu Ser Ser Leu Arg Ser Glu Asp Thr Ala Val Tyr Tyr Cys 
                85                  90                  95      


Ala Arg Ser Asp Phe Gly Asn Tyr Arg Trp Tyr Phe Asp Val Trp Gly 
            100                 105                 110         


Gln Gly Thr Thr Val Thr Val Ser Ser 
        115                 120     


<210>  503
<211>  107
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic amino acid

<400>  503

Glu Ile Val Leu Thr Gln Ser Pro Ala Thr Leu Ser Leu Ser Pro Gly 
1               5                   10                  15      


Glu Arg Ala Thr Leu Ser Cys Arg Ala Ser Gln Ser Ser Ser Asn Asn 
            20                  25                  30          


Leu His Trp Tyr Gln Gln Lys Pro Gly Gln Ala Pro Arg Val Leu Ile 
        35                  40                  45              


Lys Tyr Val Ser Gln Ser Ile Ser Gly Ile Pro Ala Arg Phe Ser Gly 
    50                  55                  60                  


Ser Gly Ser Gly Thr Asp Phe Thr Leu Thr Ile Ser Ser Leu Glu Pro 
65                  70                  75                  80  


Glu Asp Phe Ala Val Tyr Phe Cys Gln Gln Ser Asn Ser Trp Pro Phe 
                85                  90                  95      


Thr Phe Gly Gln Gly Thr Lys Leu Glu Ile Lys 
            100                 105         


<210>  504
<211>  5
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic amino acid

<400>  504

Asn Tyr Trp Met His 
1               5   


<210>  505
<211>  17
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic amino acid

<400>  505

Met Ile His Pro Asn Ser Gly Ser Thr Lys His Asn Glu Lys Phe Arg 
1               5                   10                  15      


Gly 
    


<210>  506
<211>  12
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic amino acid

<400>  506

Ser Asp Phe Gly Asn Tyr Arg Trp Tyr Phe Asp Val 
1               5                   10          


<210>  507
<211>  11
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic amino acid

<400>  507

Arg Ala Ser Gln Ser Ser Ser Asn Asn Leu His 
1               5                   10      


<210>  508
<211>  7
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic amino acid

<400>  508

Tyr Val Ser Gln Ser Ile Ser 
1               5           


<210>  509
<211>  9
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic amino acid

<400>  509

Gln Gln Ser Asn Ser Trp Pro Phe Thr 
1               5                   


<210>  510
<211>  119
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic amino acid

<400>  510

Glu Val Gln Leu Val Gln Ser Gly Ala Glu Val Lys Lys Pro Gly Ser 
1               5                   10                  15      


Ser Val Lys Val Ser Cys Lys Ala Ser Gly Phe Thr Phe Thr Asp Tyr 
            20                  25                  30          


Tyr Ile His Trp Val Lys Gln Ala Pro Gly Gln Gly Leu Glu Trp Ile 
        35                  40                  45              


Gly Leu Val Tyr Pro Tyr Ile Gly Gly Ser Ser Tyr Asn Gln Gln Phe 
    50                  55                  60                  


Lys Gly Lys Ala Thr Leu Thr Val Asp Thr Ser Thr Ser Thr Ala Tyr 
65                  70                  75                  80  


Met Glu Leu Ser Ser Leu Arg Ser Glu Asp Thr Ala Val Tyr Tyr Cys 
                85                  90                  95      


Ala Arg Gly Asp Asn Asn Tyr Asp Ala Met Asp Tyr Trp Gly Gln Gly 
            100                 105                 110         


Thr Thr Val Thr Val Ser Ser 
        115                 


<210>  511
<211>  110
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic amino acid

<400>  511

Asp Ile Val Leu Thr Gln Ser Pro Asp Ser Leu Ala Val Ser Leu Gly 
1               5                   10                  15      


Glu Arg Ala Thr Ile Ser Cys Arg Ala Ser Gln Ser Val Ser Thr Ser 
            20                  25                  30          


Thr Tyr Asn Tyr Met His Trp Tyr Gln Gln Lys Pro Gly Gln Pro Pro 
        35                  40                  45              


Lys Leu Leu Val Lys Tyr Ala Ser Asn Leu Glu Ser Gly Val Pro Asp 
    50                  55                  60                  


Arg Phe Ser Gly Ser Gly Ser Gly Thr Asp Phe Thr Leu Thr Ile Ser 
65                  70                  75                  80  


Ser Leu Gln Ala Glu Asp Val Ala Val Tyr Tyr Cys His His Thr Trp 
                85                  90                  95      


Glu Ile Arg Thr Phe Gly Gly Gly Thr Lys Val Glu Ile Lys 
            100                 105                 110 


<210>  512
<211>  5
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic amino acid

<400>  512

Asp Tyr Tyr Ile His 
1               5   


<210>  513
<211>  17
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic amino acid

<400>  513

Leu Val Tyr Pro Tyr Ile Gly Gly Ser Ser Tyr Asn Gln Gln Phe Lys 
1               5                   10                  15      


Gly 
    


<210>  514
<211>  10
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic amino acid

<400>  514

Gly Asp Asn Asn Tyr Asp Ala Met Asp Tyr 
1               5                   10  


<210>  515
<211>  15
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic amino acid

<400>  515

Arg Ala Ser Gln Ser Val Ser Thr Ser Thr Tyr Asn Tyr Met His 
1               5                   10                  15  


<210>  516
<211>  7
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic amino acid

<400>  516

Tyr Ala Ser Asn Leu Glu Ser 
1               5           


<210>  517
<211>  8
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic amino acid

<400>  517

His His Thr Trp Glu Ile Arg Thr 
1               5               


<210>  518
<211>  120
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic amino acid

<400>  518

Glu Val Gln Leu Val Glu Ser Gly Gly Gly Leu Val Gln Pro Gly Gly 
1               5                   10                  15      


Ser Leu Arg Leu Ser Cys Ala Val Ser Gly Phe Ser Leu Thr Ser Tyr 
            20                  25                  30          


Gly Val His Trp Val Arg Gln Ala Thr Gly Lys Gly Leu Glu Trp Leu 
        35                  40                  45              


Gly Val Ile Trp Ala Gly Gly Ser Thr Asn Tyr Asn Ser Ala Leu Met 
    50                  55                  60                  


Ser Arg Leu Thr Ile Ser Lys Glu Asn Ala Lys Ser Ser Val Tyr Leu 
65                  70                  75                  80  


Gln Met Asn Ser Leu Arg Ala Gly Asp Thr Ala Met Tyr Tyr Cys Ala 
                85                  90                  95      


Thr His Met Ile Thr Glu Asp Tyr Tyr Gly Met Asp Tyr Trp Gly Gln 
            100                 105                 110         


Gly Thr Thr Val Thr Val Ser Ser 
        115                 120 


<210>  519
<211>  112
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic amino acid

<400>  519

Asp Ile Val Met Thr Gln Ser Pro Asp Ser Leu Ala Val Ser Leu Gly 
1               5                   10                  15      


Glu Arg Ala Thr Ile Asn Cys Lys Ser Ser Gln Ser Leu Leu Asn Ser 
            20                  25                  30          


Arg Thr Arg Lys Asn Tyr Leu Ala Trp Tyr Gln Gln Lys Pro Gly Gln 
        35                  40                  45              


Ser Pro Lys Leu Leu Ile Tyr Trp Ala Ser Thr Arg Glu Ser Gly Val 
    50                  55                  60                  


Pro Asp Arg Phe Ser Gly Ser Gly Ser Gly Thr Asp Phe Thr Leu Thr 
65                  70                  75                  80  


Ile Ser Ser Leu Gln Ala Glu Asp Val Ala Val Tyr Tyr Cys Lys Gln 
                85                  90                  95      


Ser Tyr Asn Leu Pro Thr Phe Gly Gly Gly Thr Lys Val Glu Ile Lys 
            100                 105                 110         


<210>  520
<211>  5
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic amino acid

<400>  520

Ser Tyr Gly Val His 
1               5   


<210>  521
<211>  16
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic amino acid

<400>  521

Val Ile Trp Ala Gly Gly Ser Thr Asn Tyr Asn Ser Ala Leu Met Ser 
1               5                   10                  15      


<210>  522
<211>  12
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic amino acid

<400>  522

His Met Ile Thr Glu Asp Tyr Tyr Gly Met Asp Tyr 
1               5                   10          


<210>  523
<211>  17
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic amino acid

<400>  523

Lys Ser Ser Gln Ser Leu Leu Asn Ser Arg Thr Arg Lys Asn Tyr Leu 
1               5                   10                  15      


Ala 
    


<210>  524
<211>  7
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic amino acid

<400>  524

Trp Ala Ser Thr Arg Glu Ser 
1               5           


<210>  525
<211>  8
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic amino acid

<400>  525

Lys Gln Ser Tyr Asn Leu Pro Thr 
1               5               


<210>  526
<211>  120
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic amino acid

<400>  526

Gln Val Gln Leu Gln Gln Ser Gly Ala Glu Leu Val Arg Pro Gly Thr 
1               5                   10                  15      


Ser Val Lys Ile Ser Cys Lys Ala Ser Gly Tyr Asp Phe Thr Asn Tyr 
            20                  25                  30          


Trp Leu Gly Trp Val Lys Gln Arg Pro Gly His Gly Leu Glu Trp Ile 
        35                  40                  45              


Gly Asp Ile Tyr Pro Gly Gly Gly Asn Thr Tyr Tyr Asn Glu Lys Leu 
    50                  55                  60                  


Lys Gly Lys Ala Thr Leu Thr Ala Asp Lys Ser Ser Ser Thr Ala Tyr 
65                  70                  75                  80  


Ile His Leu Ile Ser Leu Thr Ser Glu Asp Ser Ser Val Tyr Phe Cys 
                85                  90                  95      


Ala Arg Trp Gly Asp Lys Lys Gly Asn Tyr Phe Ala Tyr Trp Gly Gln 
            100                 105                 110         


Gly Thr Leu Val Thr Val Ser Ala 
        115                 120 


<210>  527
<211>  120
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic amino acid

<400>  527

Gln Val Gln Leu Gln Gln Ser Gly Ala Glu Leu Val Arg Pro Gly Thr 
1               5                   10                  15      


Ser Val Lys Ile Ser Cys Lys Ala Ser Gly Tyr Asp Phe Thr Asn Tyr 
            20                  25                  30          


Trp Leu Gly Trp Val Lys Gln Arg Pro Gly His Gly Leu Glu Trp Ile 
        35                  40                  45              


Gly Asp Ile Tyr Pro Gly Gly Gly Asn Thr Tyr Tyr Asn Glu Lys Leu 
    50                  55                  60                  


Lys Gly Lys Ala Thr Leu Thr Ala Asp Lys Ser Ser Ser Thr Ala Tyr 
65                  70                  75                  80  


Ile His Leu Ile Ser Leu Thr Ser Glu Asp Ser Ser Val Tyr Phe Cys 
                85                  90                  95      


Ala Arg Trp Gly Asp Lys Lys Gly Asn Tyr Phe Ala Tyr Trp Gly Gln 
            100                 105                 110         


Gly Thr Leu Val Thr Val Ser Ala 
        115                 120 


<210>  528
<211>  5
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic amino acid

<400>  528

Asn Tyr Trp Leu Gly 
1               5   


<210>  529
<211>  17
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic amino acid

<400>  529

Asp Ile Tyr Pro Gly Gly Gly Asn Thr Tyr Tyr Asn Glu Lys Leu Lys 
1               5                   10                  15      


Gly 
    


<210>  530
<211>  11
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic amino acid

<400>  530

Trp Gly Asp Lys Lys Gly Asn Tyr Phe Ala Tyr 
1               5                   10      


<210>  531
<211>  12
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic amino acid

<400>  531

Thr Ala Ser Ser Ser Val Tyr Ser Ser Tyr Leu His 
1               5                   10          


<210>  532
<211>  7
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic amino acid

<400>  532

Ser Thr Ser Asn Leu Ala Ser 
1               5           


<210>  533
<211>  8
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic amino acid

<400>  533

His Gln Tyr His Arg Ser Pro Thr 
1               5               


<210>  534
<211>  122
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic amino acid

<400>  534

Gln Ile Gln Leu Val Gln Ser Gly Pro Glu Leu Lys Lys Pro Gly Glu 
1               5                   10                  15      


Thr Val Lys Ile Ser Cys Lys Ala Ser Gly Phe Ala Ile Thr Asn Phe 
            20                  25                  30          


Gly Met Asn Trp Val Lys Gln Ala Pro Gly Lys Gly Leu Lys Trp Met 
        35                  40                  45              


Gly Trp Ile Asn Leu Tyr Thr Gly Glu Pro Thr Phe Ala Asp Asp Phe 
    50                  55                  60                  


Lys Gly Arg Phe Ala Phe Ser Leu Glu Thr Ser Ala Ser Thr Ala Tyr 
65                  70                  75                  80  


Leu Gln Ile Asn Asn Leu Lys Asn Glu Asp Thr Val Ile Tyr Phe Cys 
                85                  90                  95      


Ala Arg Lys Gly Glu Thr Tyr Tyr Arg Tyr Asp Gly Phe Ala Tyr Trp 
            100                 105                 110         


Gly Gln Gly Thr Leu Val Thr Val Ser Ala 
        115                 120         


<210>  535
<211>  112
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic amino acid

<400>  535

Asp Ile Val Met Thr Gln Ala Ala Pro Ser Val Pro Val Thr Pro Gly 
1               5                   10                  15      


Glu Ser Val Ser Ile Ser Cys Arg Ser Ser Lys Ser Leu Leu His Ser 
            20                  25                  30          


Asn Gly Asn Thr His Leu Tyr Trp Phe Leu Gln Arg Pro Gly Gln Ser 
        35                  40                  45              


Pro Gln Leu Leu Ile Tyr Arg Met Ser Asn Leu Ala Ser Gly Val Pro 
    50                  55                  60                  


Asp Arg Phe Ser Gly Ser Gly Ser Gly Thr Ala Phe Thr Leu Arg Ile 
65                  70                  75                  80  


Ser Arg Val Glu Ala Glu Asp Val Gly Val Tyr Tyr Cys Met Gln Leu 
                85                  90                  95      


Leu Glu Tyr Pro Tyr Thr Phe Gly Gly Gly Thr Lys Leu Glu Ile Glu 
            100                 105                 110         


<210>  536
<211>  5
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic amino acid

<400>  536

Asn Phe Gly Met Asn 
1               5   


<210>  537
<211>  17
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic amino acid

<400>  537

Trp Ile Asn Leu Tyr Thr Gly Glu Pro Thr Phe Ala Asp Asp Phe Lys 
1               5                   10                  15      


Gly 
    


<210>  538
<211>  13
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic amino acid

<400>  538

Lys Gly Glu Thr Tyr Tyr Arg Tyr Asp Gly Phe Ala Tyr 
1               5                   10              


<210>  539
<211>  16
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic amino acid

<400>  539

Arg Ser Ser Lys Ser Leu Leu His Ser Asn Gly Asn Thr His Leu Tyr 
1               5                   10                  15      


<210>  540
<211>  7
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic amino acid

<400>  540

Arg Met Ser Asn Leu Ala Ser 
1               5           


<210>  541
<211>  9
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic amino acid

<400>  541

Met Gln Leu Leu Glu Tyr Pro Tyr Thr 
1               5                   


<210>  542
<211>  122
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic amino acid

<400>  542

Glu Val Gln Leu Val Glu Ser Gly Gly Gly Leu Val Gln Pro Gly Gly 
1               5                   10                  15      


Ser Leu Arg Leu Ser Cys Ala Ala Ser Gly Phe Thr Phe Ser Ser Phe 
            20                  25                  30          


Gly Met His Trp Val Arg Gln Ala Pro Gly Lys Gly Leu Glu Trp Val 
        35                  40                  45              


Ala Tyr Ile Ser Ser Asp Ser Ser Ala Ile Tyr Tyr Ala Asp Thr Val 
    50                  55                  60                  


Lys Gly Arg Phe Thr Ile Ser Arg Asp Asn Ala Lys Asn Ser Leu Tyr 
65                  70                  75                  80  


Leu Gln Met Asn Ser Leu Arg Asp Glu Asp Thr Ala Val Tyr Tyr Cys 
                85                  90                  95      


Ala Arg Gly Arg Glu Asn Ile Tyr Tyr Gly Ser Arg Leu Asp Tyr Trp 
            100                 105                 110         


Gly Gln Gly Thr Thr Val Thr Val Ser Ser 
        115                 120         


<210>  543
<211>  107
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic amino acid

<400>  543

Asp Ile Gln Leu Thr Gln Ser Pro Ser Phe Leu Ser Ala Ser Val Gly 
1               5                   10                  15      


Asp Arg Val Thr Ile Thr Cys Lys Ala Ser Gln Asn Val Asp Thr Asn 
            20                  25                  30          


Val Ala Trp Tyr Gln Gln Lys Pro Gly Gln Ala Pro Lys Ala Leu Ile 
        35                  40                  45              


Tyr Ser Ala Ser Tyr Arg Tyr Ser Gly Val Pro Ser Arg Phe Ser Gly 
    50                  55                  60                  


Ser Gly Ser Gly Thr Asp Phe Thr Leu Thr Ile Ser Ser Leu Gln Pro 
65                  70                  75                  80  


Glu Asp Phe Ala Thr Tyr Tyr Cys Gln Gln Tyr Asn Asn Tyr Pro Phe 
                85                  90                  95      


Thr Phe Gly Gln Gly Thr Lys Leu Glu Ile Lys 
            100                 105         


<210>  544
<211>  4
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic amino acid

<400>  544

Phe Gly Met His 
1               


<210>  545
<211>  16
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic amino acid

<400>  545

Tyr Ile Ser Ser Asp Ser Ser Ala Ile Tyr Tyr Ala Asp Thr Val Lys 
1               5                   10                  15      


<210>  546
<211>  13
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic amino acid

<400>  546

Gly Arg Glu Asn Ile Tyr Tyr Gly Ser Arg Leu Asp Tyr 
1               5                   10              


<210>  547
<211>  11
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic amino acid

<400>  547

Lys Ala Ser Gln Asn Val Asp Thr Asn Val Ala 
1               5                   10      


<210>  548
<211>  7
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic amino acid

<400>  548

Ser Ala Ser Tyr Arg Tyr Ser 
1               5           


<210>  549
<211>  9
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic amino acid

<400>  549

Gln Gln Tyr Asn Asn Tyr Pro Phe Thr 
1               5                   


<210>  550
<211>  122
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic amino acid

<400>  550

Asp Val Gln Leu Val Glu Ser Gly Gly Gly Leu Val Gln Pro Gly Gly 
1               5                   10                  15      


Ser Arg Lys Leu Ser Cys Ala Ala Ser Gly Phe Thr Phe Ser Ser Phe 
            20                  25                  30          


Gly Met His Trp Val Arg Gln Ala Pro Glu Lys Gly Leu Glu Trp Val 
        35                  40                  45              


Ala Tyr Ile Ser Ser Asp Ser Ser Ala Ile Tyr Tyr Ala Asp Thr Val 
    50                  55                  60                  


Lys Gly Arg Phe Thr Ile Ser Arg Asp Asn Pro Lys Asn Thr Leu Phe 
65                  70                  75                  80  


Leu Gln Met Thr Ser Leu Arg Ser Glu Asp Thr Ala Met Tyr Tyr Cys 
                85                  90                  95      


Gly Arg Gly Arg Glu Asn Ile Tyr Tyr Gly Ser Arg Leu Asp Tyr Trp 
            100                 105                 110         


Gly Gln Gly Thr Thr Leu Thr Val Ser Ser 
        115                 120         


<210>  551
<211>  107
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic amino acid

<400>  551

Asp Ile Ala Met Thr Gln Ser Gln Lys Phe Met Ser Thr Ser Val Gly 
1               5                   10                  15      


Asp Arg Val Ser Val Thr Cys Lys Ala Ser Gln Asn Val Asp Thr Asn 
            20                  25                  30          


Val Ala Trp Tyr Gln Gln Lys Pro Gly Gln Ser Pro Lys Ala Leu Ile 
        35                  40                  45              


Tyr Ser Ala Ser Tyr Arg Tyr Ser Gly Val Pro Asp Arg Phe Thr Gly 
    50                  55                  60                  


Ser Gly Ser Gly Thr Asp Phe Thr Leu Thr Ile Asn Asn Val Gln Ser 
65                  70                  75                  80  


Glu Asp Leu Ala Glu Tyr Phe Cys Gln Gln Tyr Asn Asn Tyr Pro Phe 
                85                  90                  95      


Thr Phe Gly Ser Gly Thr Lys Leu Glu Ile Lys 
            100                 105         


<210>  552
<211>  21
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic amino acid

<400>  552

Val Gly Val Val Gly Gly Leu Leu Gly Ser Leu Val Leu Leu Val Trp 
1               5                   10                  15      


Val Leu Ala Val Ile 
            20      


<210>  553
<211>  27
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic amino acid

<400>  553

Phe Trp Val Leu Val Val Val Gly Gly Val Leu Ala Cys Tyr Ser Leu 
1               5                   10                  15      


Leu Val Thr Val Ala Phe Ile Ile Phe Trp Val 
            20                  25          


<210>  554
<211>  21
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic amino acid

<400>  554

Ile Leu Val Ile Phe Ser Gly Met Phe Leu Val Phe Thr Leu Ala Gly 
1               5                   10                  15      


Ala Leu Phe Leu His 
            20      


<210>  555
<211>  24
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic amino acid

<400>  555

Ile Tyr Ile Trp Ala Pro Leu Ala Gly Thr Cys Gly Val Leu Leu Leu 
1               5                   10                  15      


Ser Leu Val Ile Thr Leu Tyr Cys 
            20                  


<210>  556
<211>  45
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic amino acid

<400>  556

Thr Thr Thr Pro Ala Pro Arg Pro Pro Thr Pro Ala Pro Thr Ile Ala 
1               5                   10                  15      


Ser Gln Pro Leu Ser Leu Arg Pro Glu Ala Cys Arg Pro Ala Ala Gly 
            20                  25                  30          


Gly Ala Val His Thr Arg Gly Leu Asp Phe Ala Cys Asp 
        35                  40                  45  


<210>  557
<211>  25
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic amino acid

<400>  557

Ile Pro Trp Leu Gly His Leu Leu Val Gly Leu Ser Gly Ala Phe Gly 
1               5                   10                  15      


Phe Ile Ile Leu Val Tyr Leu Leu Ile 
            20                  25  


<210>  558
<211>  31
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic amino acid

<400>  558

Glu Pro Lys Ser Cys Asp Lys Thr His Thr Cys Pro Pro Cys Pro Ala 
1               5                   10                  15      


Pro Glu Leu Leu Gly Gly Pro Ser Val Phe Leu Phe Pro Pro Lys 
            20                  25                  30      


<210>  559
<211>  23
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic amino acid

<400>  559

Glu Pro Lys Ser Cys Asp Lys Thr His Thr Cys Pro Pro Cys Pro Ala 
1               5                   10                  15      


Pro Glu Leu Leu Gly Gly Pro 
            20              


<210>  560
<211>  230
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic amino acid

<400>  560

Glu Ser Lys Tyr Gly Pro Pro Cys Pro Pro Cys Pro Ala Pro Glu Phe 
1               5                   10                  15      


Leu Gly Gly Pro Ser Val Phe Leu Phe Pro Pro Lys Pro Lys Asp Thr 
            20                  25                  30          


Leu Met Ile Ser Arg Thr Pro Glu Val Thr Cys Val Val Val Asp Val 
        35                  40                  45              


Ser Gln Glu Asp Pro Glu Val Gln Phe Asn Trp Tyr Val Asp Gly Val 
    50                  55                  60                  


Glu Val His Asn Ala Lys Thr Lys Pro Arg Glu Glu Gln Phe Asn Ser 
65                  70                  75                  80  


Thr Tyr Arg Val Val Ser Val Leu Thr Val Leu His Gln Asp Trp Leu 
                85                  90                  95      


Asn Gly Lys Glu Tyr Lys Cys Lys Val Ser Asn Lys Gly Leu Pro Ser 
            100                 105                 110         


Ser Ile Glu Lys Thr Ile Ser Lys Ala Lys Gly Gln Pro Arg Glu Pro 
        115                 120                 125             


Gln Val Tyr Thr Leu Pro Pro Ser Gln Glu Glu Met Thr Lys Asn Gln 
    130                 135                 140                 


Val Ser Leu Thr Cys Leu Val Lys Gly Phe Tyr Pro Ser Asp Ile Ala 
145                 150                 155                 160 


Val Glu Trp Glu Ser Asn Gly Gln Pro Glu Asn Asn Tyr Lys Thr Thr 
                165                 170                 175     


Pro Pro Val Leu Asp Ser Asp Gly Ser Phe Phe Leu Tyr Ser Arg Leu 
            180                 185                 190         


Thr Val Asp Lys Ser Arg Trp Gln Glu Gly Asn Val Phe Ser Cys Ser 
        195                 200                 205             


Val Met His Glu Ala Leu His Asn His Tyr Thr Gln Lys Ser Leu Ser 
    210                 215                 220                 


Leu Ser Leu Gly Lys Met 
225                 230 


<210>  561
<211>  282
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic amino acid

<400>  561

Arg Trp Pro Glu Ser Pro Lys Ala Gln Ala Ser Ser Val Pro Thr Ala 
1               5                   10                  15      


Gln Pro Gln Ala Glu Gly Ser Leu Ala Lys Ala Thr Thr Ala Pro Ala 
            20                  25                  30          


Thr Thr Arg Asn Thr Gly Arg Gly Gly Glu Glu Lys Lys Lys Glu Lys 
        35                  40                  45              


Glu Lys Glu Glu Gln Glu Glu Arg Glu Thr Lys Thr Pro Glu Cys Pro 
    50                  55                  60                  


Ser His Thr Gln Pro Leu Gly Val Tyr Leu Leu Thr Pro Ala Val Gln 
65                  70                  75                  80  


Asp Leu Trp Leu Arg Asp Lys Ala Thr Phe Thr Cys Phe Val Val Gly 
                85                  90                  95      


Ser Asp Leu Lys Asp Ala His Leu Thr Trp Glu Val Ala Gly Lys Val 
            100                 105                 110         


Pro Thr Gly Gly Val Glu Glu Gly Leu Leu Glu Arg His Ser Asn Gly 
        115                 120                 125             


Ser Gln Ser Gln His Ser Arg Leu Thr Leu Pro Arg Ser Leu Trp Asn 
    130                 135                 140                 


Ala Gly Thr Ser Val Thr Cys Thr Leu Asn His Pro Ser Leu Pro Pro 
145                 150                 155                 160 


Gln Arg Leu Met Ala Leu Arg Glu Pro Ala Ala Gln Ala Pro Val Lys 
                165                 170                 175     


Leu Ser Leu Asn Leu Leu Ala Ser Ser Asp Pro Pro Glu Ala Ala Ser 
            180                 185                 190         


Trp Leu Leu Cys Glu Val Ser Gly Phe Ser Pro Pro Asn Ile Leu Leu 
        195                 200                 205             


Met Trp Leu Glu Asp Gln Arg Glu Val Asn Thr Ser Gly Phe Ala Pro 
    210                 215                 220                 


Ala Arg Pro Pro Pro Gln Pro Gly Ser Thr Thr Phe Trp Ala Trp Ser 
225                 230                 235                 240 


Val Leu Arg Val Pro Ala Pro Pro Ser Pro Gln Pro Ala Thr Tyr Thr 
                245                 250                 255     


Cys Val Val Ser His Glu Asp Ser Arg Thr Leu Leu Asn Ala Ser Arg 
            260                 265                 270         


Ser Leu Glu Val Ser Tyr Val Thr Asp His 
        275                 280         


<210>  562
<211>  63
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Synthetic nucleotide

<400>  562
gttggtgtcg tgggcggcct gctgggcagc ctggtgctgc tagtctgggt cctggccgtc       60

atc                                                                     63


<210>  563
<211>  81
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Synthetic nucleotide

<400>  563
ttttgggtgc tggtggtggt tggtggagtc ctggcttgct atagcttgct agtaacagtg       60

gcctttatta ttttctgggt g                                                 81


<210>  564
<211>  63
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Synthetic nucleotide

<400>  564
attctggtga tttttagcgg catgtttctg gtgtttaccc tggcgggcgc gctgtttctg       60

cat                                                                     63


<210>  565
<211>  72
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Synthetic nucleotide

<400>  565
atctacatct gggcgccctt ggccgggact tgtggggtcc ttctcctgtc actggttatc       60

accctttact gc                                                           72


<210>  566
<211>  135
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Synthetic nucleotide

<400>  566
accacgacgc cagcgccgcg accaccaaca ccggcgccca ccatcgcgtc gcagcccctg       60

tccctgcgcc cagaggcgtg ccggccagcg gcggggggcg cagtgcacac gagggggctg      120

gacttcgcct gtgat                                                       135


<210>  567
<211>  75
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Synthetic nucleotide

<400>  567
attccgtggc tgggccatct gctggtgggc ctgagcggcg cgtttggctt tattattctg       60

gtgtatctgc tgatt                                                        75


<210>  568
<211>  93
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Synthetic nucleotide

<400>  568
gaaccgaaaa gctgcgataa aacccatacc tgcccgccgt gcccggcgcc ggaactgctg       60

ggcggcccga gcgtgtttct gtttccgccg aaa                                    93


<210>  569
<211>  69
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Synthetic nucleotide

<400>  569
gaaccgaaaa gctgcgataa aacccatacc tgcccgccgt gcccggcgcc ggaactgctg       60

ggcggcccg                                                               69


<210>  570
<211>  690
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Synthetic nucleotide

<400>  570
gagagcaagt acggccctcc ctgcccccct tgccctgccc ccgagttcct gggcggaccc       60

agcgtgttcc tgttcccccc caagcccaag gacaccctga tgatcagccg gacccccgag      120

gtgacctgtg tggtggtgga cgtgtcccag gaggaccccg aggtccagtt caactggtac      180

gtggacggcg tggaggtgca caacgccaag accaagcccc gggaggagca gttcaatagc      240

acctaccggg tggtgtccgt gctgaccgtg ctgcaccagg actggctgaa cggcaaggaa      300

tacaagtgta aggtgtccaa caagggcctg cccagcagca tcgagaaaac catcagcaag      360

gccaagggcc agcctcggga gccccaggtg tacaccctgc cccctagcca agaggagatg      420

accaagaacc aggtgtccct gacctgcctg gtgaagggct tctaccccag cgacatcgcc      480

gtggagtggg agagcaacgg ccagcccgag aacaactaca agaccacccc ccctgtgctg      540

gacagcgacg gcagcttctt cctgtacagc cggctgaccg tggacaagag ccggtggcag      600

gagggcaacg tctttagctg ctccgtgatg cacgaggccc tgcacaacca ctacacccag      660

aagagcctga gcctgtccct gggcaagatg                                       690


<210>  571
<211>  847
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Synthetic nucleotide

<400>  571
aggtggcccg aaagtcccaa ggcccaggca tctagtgttc ctactgcaca gccccaggca       60

gaaggcagcc tagccaaagc tactactgca cctgccacta cgcgcaatac tggccgtggc      120

ggggaggaga agaaaaagga gaaagagaaa gaagaacagg aagagaggga gaccaagacc      180

cctgaatgtc catcccatac ccagccgctg ggcgtctatc tcttgactcc cgcagtacag      240

gacttgtggc ttagagataa ggccaccttt acatgtttcg tcgtgggctc tgacctgaag      300

gatgcccatt tgacttggga ggttgccgga aaggtaccca cagggggggt tgaggaaggg      360

ttgctggagc gccattccaa tggctctcag agccagcact caagactcac ccttccgaga      420

tccctgtgga acgccgggac ctctgtcaca tgtactctaa atcatcctag cctgccccca      480

cagcgtctga tggcccttag agagccagcc gcccaggcac cagttaagct tagcctgaat      540

ctgctcgcca gtagtgatcc cccagaggcc gccagctggc tcttatgcga agtgtccggc      600

tttagcccgc ccaacatctt gctcatgtgg ctggaggacc agcgagaagt gaacaccagc      660

ggcttcgctc cagcccggcc cccaccccag ccgggttcta ccacattctg ggcctggagt      720

gtcttaaggg tcccagcacc acctagcccc cagccagcca catacacctg tgttgtgtcc      780

catgaagata gcaggaccct gctaaatgct tctaggagtc tggaggtttc ctacgtgact      840

gaccatt                                                                847


<210>  572
<211>  41
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic amino acid

<400>  572

Arg Ser Lys Arg Ser Arg Leu Leu His Ser Asp Tyr Met Asn Met Thr 
1               5                   10                  15      


Pro Arg Arg Pro Gly Pro Thr Arg Lys His Tyr Gln Pro Tyr Ala Pro 
            20                  25                  30          


Pro Arg Asp Phe Ala Ala Tyr Arg Ser 
        35                  40      


<210>  573
<211>  42
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic amino acid

<400>  573

Ala Leu Tyr Leu Leu Arg Arg Asp Gln Arg Leu Pro Pro Asp Ala His 
1               5                   10                  15      


Lys Pro Pro Gly Gly Gly Ser Phe Arg Thr Pro Ile Gln Glu Glu Gln 
            20                  25                  30          


Ala Asp Ala His Ser Thr Leu Ala Lys Ile 
        35                  40          


<210>  574
<211>  38
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic amino acid

<400>  574

Cys Trp Leu Thr Lys Lys Lys Tyr Ser Ser Ser Val His Asp Pro Asn 
1               5                   10                  15      


Gly Glu Tyr Met Phe Met Arg Ala Val Asn Thr Ala Lys Lys Ser Arg 
            20                  25                  30          


Leu Thr Asp Val Thr Leu 
        35              


<210>  575
<211>  42
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic amino acid

<400>  575

Lys Arg Gly Arg Lys Lys Leu Leu Tyr Ile Phe Lys Gln Pro Phe Met 
1               5                   10                  15      


Arg Pro Val Gln Thr Thr Gln Glu Glu Asp Gly Cys Ser Cys Arg Phe 
            20                  25                  30          


Pro Glu Glu Glu Glu Gly Gly Cys Glu Leu 
        35                  40          


<210>  576
<211>  48
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic amino acid

<400>  576

Gln Arg Arg Lys Tyr Arg Ser Asn Lys Gly Glu Ser Pro Val Glu Pro 
1               5                   10                  15      


Ala Glu Pro Cys Arg Tyr Ser Cys Pro Arg Glu Glu Glu Gly Ser Thr 
            20                  25                  30          


Ile Pro Ile Gln Glu Asp Tyr Arg Lys Pro Glu Pro Ala Cys Ser Pro 
        35                  40                  45              


<210>  577
<211>  112
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic amino acid

<400>  577

Arg Val Lys Phe Ser Arg Ser Ala Asp Ala Pro Ala Tyr Lys Gln Gly 
1               5                   10                  15      


Gln Asn Gln Leu Tyr Asn Glu Leu Asn Leu Gly Arg Arg Glu Glu Tyr 
            20                  25                  30          


Asp Val Leu Asp Lys Arg Arg Gly Arg Asp Pro Glu Met Gly Gly Lys 
        35                  40                  45              


Pro Arg Arg Lys Asn Pro Gln Glu Gly Leu Tyr Asn Glu Leu Gln Lys 
    50                  55                  60                  


Asp Lys Met Ala Glu Ala Tyr Ser Glu Ile Gly Met Lys Gly Glu Arg 
65                  70                  75                  80  


Arg Arg Gly Lys Gly His Asp Gly Leu Tyr Gln Gly Leu Ser Thr Ala 
                85                  90                  95      


Thr Lys Asp Thr Tyr Asp Ala Leu His Met Gln Ala Leu Pro Pro Arg 
            100                 105                 110         


<210>  578
<211>  286
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic amino acid

<400>  578

Asn Cys Arg Asn Thr Gly Pro Trp Leu Lys Lys Val Leu Lys Cys Asn 
1               5                   10                  15      


Thr Pro Asp Pro Ser Lys Phe Phe Ser Gln Leu Ser Ser Glu His Gly 
            20                  25                  30          


Gly Asp Val Gln Lys Trp Leu Ser Ser Pro Phe Pro Ser Ser Ser Phe 
        35                  40                  45              


Ser Pro Gly Gly Leu Ala Pro Glu Ile Ser Pro Leu Glu Val Leu Glu 
    50                  55                  60                  


Arg Asp Lys Val Thr Gln Leu Leu Leu Gln Gln Asp Lys Val Pro Glu 
65                  70                  75                  80  


Pro Ala Ser Leu Ser Ser Asn His Ser Leu Thr Ser Cys Phe Thr Asn 
                85                  90                  95      


Gln Gly Tyr Phe Phe Phe His Leu Pro Asp Ala Leu Glu Ile Glu Ala 
            100                 105                 110         


Cys Gln Val Tyr Phe Thr Tyr Asp Pro Tyr Ser Glu Glu Asp Pro Asp 
        115                 120                 125             


Glu Gly Val Ala Gly Ala Pro Thr Gly Ser Ser Pro Gln Pro Leu Gln 
    130                 135                 140                 


Pro Leu Ser Gly Glu Asp Asp Ala Tyr Cys Thr Phe Pro Ser Arg Asp 
145                 150                 155                 160 


Asp Leu Leu Leu Phe Ser Pro Ser Leu Leu Gly Gly Pro Ser Pro Pro 
                165                 170                 175     


Ser Thr Ala Pro Gly Gly Ser Gly Ala Gly Glu Glu Arg Met Pro Pro 
            180                 185                 190         


Ser Leu Gln Glu Arg Val Pro Arg Asp Trp Asp Pro Gln Pro Leu Gly 
        195                 200                 205             


Pro Pro Thr Pro Gly Val Pro Asp Leu Val Asp Phe Gln Pro Pro Pro 
    210                 215                 220                 


Glu Leu Val Leu Arg Glu Ala Gly Glu Glu Val Pro Asp Ala Gly Pro 
225                 230                 235                 240 


Arg Glu Gly Val Ser Phe Pro Trp Ser Arg Pro Pro Gly Gln Gly Glu 
                245                 250                 255     


Phe Arg Ala Leu Asn Ala Arg Leu Pro Leu Asn Thr Asp Ala Tyr Leu 
            260                 265                 270         


Ser Leu Gln Glu Leu Gln Gly Gln Asp Pro Thr His Leu Val 
        275                 280                 285     


<210>  579
<211>  86
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic amino acid

<400>  579

Glu Arg Thr Met Pro Arg Ile Pro Thr Leu Lys Asn Leu Glu Asp Leu 
1               5                   10                  15      


Val Thr Glu Tyr His Gly Asn Phe Ser Ala Trp Ser Gly Val Ser Lys 
            20                  25                  30          


Gly Leu Ala Glu Ser Leu Gln Pro Asp Tyr Ser Glu Arg Leu Cys Leu 
        35                  40                  45              


Val Ser Glu Ile Pro Pro Lys Gly Gly Ala Leu Gly Glu Gly Pro Gly 
    50                  55                  60                  


Ala Ser Pro Cys Asn Gln His Ser Pro Tyr Trp Ala Pro Pro Cys Tyr 
65                  70                  75                  80  


Thr Leu Lys Pro Glu Thr 
                85      


<210>  580
<211>  192
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic amino acid

<400>  580

Tyr Arg Val Asp Leu Val Leu Phe Tyr Arg His Leu Thr Arg Arg Asp 
1               5                   10                  15      


Glu Thr Leu Thr Asp Gly Lys Thr Tyr Asp Ala Phe Val Ser Tyr Leu 
            20                  25                  30          


Lys Glu Cys Arg Pro Glu Asn Gly Glu Glu His Thr Phe Ala Val Glu 
        35                  40                  45              


Ile Leu Pro Arg Val Leu Glu Lys His Phe Gly Tyr Lys Leu Cys Ile 
    50                  55                  60                  


Phe Glu Arg Asp Val Val Pro Gly Gly Ala Val Val Asp Glu Ile His 
65                  70                  75                  80  


Ser Leu Ile Glu Lys Ser Arg Arg Leu Ile Ile Val Leu Ser Lys Ser 
                85                  90                  95      


Tyr Met Ser Asn Glu Val Arg Tyr Glu Leu Glu Ser Gly Leu His Glu 
            100                 105                 110         


Ala Leu Val Glu Arg Lys Ile Lys Ile Ile Leu Ile Glu Phe Thr Pro 
        115                 120                 125             


Val Thr Asp Phe Thr Phe Leu Pro Gln Ser Leu Lys Leu Leu Lys Ser 
    130                 135                 140                 


His Arg Val Leu Lys Trp Lys Ala Asp Lys Ser Leu Ser Tyr Asn Ser 
145                 150                 155                 160 


Arg Phe Trp Lys Asn Leu Leu Tyr Leu Met Pro Ala Lys Thr Val Lys 
                165                 170                 175     


Pro Gly Arg Asp Glu Pro Glu Val Leu Pro Val Leu Ser Glu Ser Leu 
            180                 185                 190         


<210>  581
<211>  195
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic amino acid

<400>  581

Lys Lys Arg Ile Lys Pro Ile Val Trp Pro Ser Leu Pro Asp His Lys 
1               5                   10                  15      


Lys Thr Leu Glu His Leu Cys Lys Lys Pro Arg Lys Asn Leu Asn Val 
            20                  25                  30          


Ser Phe Asn Pro Glu Ser Phe Leu Asp Cys Gln Ile His Arg Val Asp 
        35                  40                  45              


Asp Ile Gln Ala Arg Asp Glu Val Glu Gly Phe Leu Gln Asp Thr Phe 
    50                  55                  60                  


Pro Gln Gln Leu Glu Glu Ser Glu Lys Gln Arg Leu Gly Gly Asp Val 
65                  70                  75                  80  


Gln Ser Pro Asn Cys Pro Ser Glu Asp Val Val Ile Thr Pro Glu Ser 
                85                  90                  95      


Phe Gly Arg Asp Ser Ser Leu Thr Cys Leu Ala Gly Asn Val Ser Ala 
            100                 105                 110         


Cys Asp Ala Pro Ile Leu Ser Ser Ser Arg Ser Leu Asp Cys Arg Glu 
        115                 120                 125             


Ser Gly Lys Asn Gly Pro His Val Tyr Gln Asp Leu Leu Leu Ser Leu 
    130                 135                 140                 


Gly Thr Thr Asn Ser Thr Leu Pro Pro Pro Phe Ser Leu Gln Ser Gly 
145                 150                 155                 160 


Ile Leu Thr Leu Asn Pro Val Ala Gln Gly Gln Pro Ile Leu Thr Ser 
                165                 170                 175     


Leu Gly Ser Asn Gln Glu Glu Ala Tyr Val Thr Met Ser Ser Phe Tyr 
            180                 185                 190         


Gln Asn Gln 
        195 


<210>  582
<211>  92
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic amino acid

<400>  582

Asn Arg Ala Ala Arg His Leu Cys Pro Pro Leu Pro Thr Pro Cys Ala 
1               5                   10                  15      


Ser Ser Ala Ile Glu Phe Pro Gly Gly Lys Glu Thr Trp Gln Trp Ile 
            20                  25                  30          


Asn Pro Val Asp Phe Gln Glu Glu Ala Ser Leu Gln Glu Ala Leu Val 
        35                  40                  45              


Val Glu Met Ser Trp Asp Lys Gly Glu Arg Thr Glu Pro Leu Glu Lys 
    50                  55                  60                  


Thr Glu Leu Pro Glu Gly Ala Pro Glu Leu Ala Leu Asp Thr Glu Leu 
65                  70                  75                  80  


Ser Leu Glu Asp Gly Asp Arg Cys Lys Ala Lys Met 
                85                  90          


<210>  583
<211>  219
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic amino acid

<400>  583

His Tyr Phe Gln Gln Lys Val Phe Val Leu Leu Ala Ala Leu Arg Pro 
1               5                   10                  15      


Gln Trp Cys Ser Arg Glu Ile Pro Asp Pro Ala Asn Ser Thr Cys Ala 
            20                  25                  30          


Lys Lys Tyr Pro Ile Ala Glu Glu Lys Thr Gln Leu Pro Leu Asp Arg 
        35                  40                  45              


Leu Leu Ile Asp Trp Pro Thr Pro Glu Asp Pro Glu Pro Leu Val Ile 
    50                  55                  60                  


Ser Glu Val Leu His Gln Val Thr Pro Val Phe Arg His Pro Pro Cys 
65                  70                  75                  80  


Ser Asn Trp Pro Gln Arg Glu Lys Gly Ile Gln Gly His Gln Ala Ser 
                85                  90                  95      


Glu Lys Asp Met Met His Ser Ala Ser Ser Pro Pro Pro Pro Arg Ala 
            100                 105                 110         


Leu Gln Ala Glu Ser Arg Gln Leu Val Asp Leu Tyr Lys Val Leu Glu 
        115                 120                 125             


Ser Arg Gly Ser Asp Pro Lys Pro Glu Asn Pro Ala Cys Pro Trp Thr 
    130                 135                 140                 


Val Leu Pro Ala Gly Asp Leu Pro Thr His Asp Gly Tyr Leu Pro Ser 
145                 150                 155                 160 


Asn Ile Asp Asp Leu Pro Ser His Glu Ala Pro Leu Ala Asp Ser Leu 
                165                 170                 175     


Glu Glu Leu Glu Pro Gln His Ile Ser Leu Ser Val Phe Pro Ser Ser 
            180                 185                 190         


Ser Leu His Pro Leu Thr Phe Ser Cys Gly Asp Lys Leu Thr Leu Asp 
        195                 200                 205             


Gln Leu Lys Met Arg Cys Asp Ser Leu Met Leu 
    210                 215                 


<210>  584
<211>  39
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic amino acid

<400>  584

Lys Ser Arg Gln Thr Pro Pro Leu Ala Ser Val Glu Met Glu Ala Met 
1               5                   10                  15      


Glu Ala Leu Pro Val Thr Trp Gly Thr Ser Ser Arg Asp Glu Asp Leu 
            20                  25                  30          


Glu Asn Cys Ser His His Leu 
        35                  


<210>  585
<211>  285
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic amino acid

<400>  585

Ser Leu Lys Thr His Pro Leu Trp Arg Leu Trp Lys Lys Ile Trp Ala 
1               5                   10                  15      


Val Pro Ser Pro Glu Arg Phe Phe Met Pro Leu Tyr Lys Gly Cys Ser 
            20                  25                  30          


Gly Asp Phe Lys Lys Trp Val Gly Ala Pro Phe Thr Gly Ser Ser Leu 
        35                  40                  45              


Glu Leu Gly Pro Trp Ser Pro Glu Val Pro Ser Thr Leu Glu Val Tyr 
    50                  55                  60                  


Ser Cys His Pro Pro Arg Ser Pro Ala Lys Arg Leu Gln Leu Thr Glu 
65                  70                  75                  80  


Leu Gln Glu Pro Ala Glu Leu Val Glu Ser Asp Gly Val Pro Lys Pro 
                85                  90                  95      


Ser Phe Trp Pro Thr Ala Gln Asn Ser Gly Gly Ser Ala Tyr Ser Glu 
            100                 105                 110         


Glu Arg Asp Arg Pro Tyr Gly Leu Val Ser Ile Asp Thr Val Thr Val 
        115                 120                 125             


Leu Asp Ala Glu Gly Pro Cys Thr Trp Pro Cys Ser Cys Glu Asp Asp 
    130                 135                 140                 


Gly Tyr Pro Ala Leu Asp Leu Asp Ala Gly Leu Glu Pro Ser Pro Gly 
145                 150                 155                 160 


Leu Glu Asp Pro Leu Leu Asp Ala Gly Thr Thr Val Leu Ser Cys Gly 
                165                 170                 175     


Cys Val Ser Ala Gly Ser Pro Gly Leu Gly Gly Pro Leu Gly Ser Leu 
            180                 185                 190         


Leu Asp Arg Leu Lys Pro Pro Leu Ala Asp Gly Glu Asp Trp Ala Gly 
        195                 200                 205             


Gly Leu Pro Trp Gly Gly Arg Ser Pro Gly Gly Val Ser Glu Ser Glu 
    210                 215                 220                 


Ala Gly Ser Pro Leu Ala Gly Leu Asp Met Asp Thr Phe Asp Ser Gly 
225                 230                 235                 240 


Phe Val Gly Ser Asp Cys Ser Ser Pro Val Glu Cys Asp Phe Thr Ser 
                245                 250                 255     


Pro Gly Asp Glu Gly Pro Pro Arg Ser Tyr Leu Arg Gln Trp Val Val 
            260                 265                 270         


Ile Pro Pro Pro Leu Ser Ser Pro Gly Pro Gln Ala Ser 
        275                 280                 285 


<210>  586
<211>  220
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic amino acid

<400>  586

Pro Leu Pro Pro Glu Met Ser Gly Thr Met Leu Met Leu Ala Val Leu 
1               5                   10                  15      


Leu Pro Leu Ala Phe Phe Leu Leu Leu Ala Thr Val Phe Ser Cys Ile 
            20                  25                  30          


Trp Lys Ser His Pro Ser Leu Cys Arg Lys Leu Gly Ser Leu Leu Lys 
        35                  40                  45              


Arg Arg Pro Gln Gly Glu Gly Pro Asn Pro Val Ala Gly Ser Trp Glu 
    50                  55                  60                  


Pro Pro Lys Ala His Pro Tyr Phe Pro Asp Leu Val Gln Pro Leu Leu 
65                  70                  75                  80  


Pro Ile Ser Gly Asp Val Ser Pro Val Ser Thr Gly Leu Pro Ala Ala 
                85                  90                  95      


Pro Val Leu Glu Ala Gly Val Pro Gln Gln Gln Ser Pro Leu Asp Leu 
            100                 105                 110         


Thr Arg Glu Pro Gln Leu Glu Pro Gly Glu Gln Ser Gln Val Ala His 
        115                 120                 125             


Gly Thr Asn Gly Ile His Val Thr Gly Gly Ser Met Thr Ile Thr Gly 
    130                 135                 140                 


Asn Ile Tyr Ile Tyr Asn Gly Pro Val Leu Gly Gly Pro Pro Gly Pro 
145                 150                 155                 160 


Gly Asp Leu Pro Ala Thr Pro Glu Pro Pro Tyr Pro Ile Pro Glu Glu 
                165                 170                 175     


Gly Asp Pro Gly Pro Pro Gly Leu Ser Thr Pro His Gln Glu Asp Gly 
            180                 185                 190         


Lys Ala Trp His Leu Ala Glu Thr Glu His Cys Gly Ala Thr Pro Ser 
        195                 200                 205             


Asn Arg Gly Pro Arg Asn Gln Phe Ile Thr His Asp 
    210                 215                 220 


<210>  587
<211>  10
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic amino acid

<400>  587

Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser 
1               5                   10  


<210>  588
<211>  123
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Synthetic nucleotide

<400>  588
aggagtaaga ggagcaggct cctgcacagt gactacatga acatgactcc ccgccgcccc       60

gggcccaccc gcaagcatta ccagccctat gccccaccac gcgacttcgc agcctatcgc      120

tcc                                                                    123


<210>  589
<211>  126
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Synthetic nucleotide

<400>  589
gcgctgtatc tgctgcgccg cgatcagcgc ctgccgccgg atgcgcataa accgccgggc       60

ggcggcagct ttcgcacccc gattcaggaa gaacaggcgg atgcgcatag caccctggcg      120

aaaatt                                                                 126


<210>  590
<211>  105
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Synthetic nucleotide

<400>  590
acaaaaaaga agtattcatc cagtgtgcac gaccctaacg gtgaatacat gttcatgaga       60

gcagtgaaca cagccaaaaa atccagactc acagatgtga cccta                      105


<210>  591
<211>  126
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Synthetic nucleotide

<400>  591
aaacggggca gaaagaaact cctgtatata ttcaaacaac catttatgag accagtacaa       60

actactcaag aggaagatgg ctgtagctgc cgatttccag aagaagaaga aggaggatgt      120

gaactg                                                                 126


<210>  592
<211>  144
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Synthetic nucleotide

<400>  592
caacgaagga aatatagatc aaacaaagga gaaagtcctg tggagcctgc agagccttgt       60

cgttacagct gccccaggga ggaggagggc agcaccatcc ccatccagga ggattaccga      120

aaaccggagc ctgcctgctc cccc                                             144


<210>  593
<211>  336
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Synthetic nucleotide

<400>  593
agagtgaagt tcagcaggag cgcagacgcc cccgcgtaca agcagggcca gaaccagctc       60

tataacgagc tcaatctagg acgaagagag gagtacgatg ttttggacaa gagacgtggc      120

cgggaccctg agatgggggg aaagccgaga aggaagaacc ctcaggaagg cctgtacaat      180

gaactgcaga aagataagat ggcggaggcc tacagtgaga ttgggatgaa aggcgagcgc      240

cggaggggca aggggcacga tggcctttac cagggtctca gtacagccac caaggacacc      300

tacgacgccc ttcacatgca ggccctgccc cctcgc                                336


<210>  594
<211>  858
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Synthetic nucleotide

<400>  594
aactgcagga acaccgggcc atggctgaag aaggtcctga agtgtaacac cccagacccc       60

tcgaagttct tttcccagct gagctcagag catggaggag acgtccagaa gtggctctct      120

tcgcccttcc cctcatcgtc cttcagccct ggcggcctgg cacctgagat ctcgccacta      180

gaagtgctgg agagggacaa ggtgacgcag ctgctcctgc agcaggacaa ggtgcctgag      240

cccgcatcct taagcagcaa ccactcgctg accagctgct tcaccaacca gggttacttc      300

ttcttccacc tcccggatgc cttggagata gaggcctgcc aggtgtactt tacttacgac      360

ccctactcag aggaagaccc tgatgagggt gtggccgggg cacccacagg gtcttccccc      420

caacccctgc agcctctgtc aggggaggac gacgcctact gcaccttccc ctccagggat      480

gacctgctgc tcttctcccc cagtctcctc ggtggcccca gccccccaag cactgcccct      540

gggggcagtg gggccggtga agagaggatg cccccttctt tgcaagaaag agtccccaga      600

gactgggacc cccagcccct ggggcctccc accccaggag tcccagacct ggtggatttt      660

cagccacccc ctgagctggt gctgcgagag gctggggagg aggtccctga cgctggcccc      720

agggagggag tcagtttccc ctggtccagg cctcctgggc agggggagtt cagggccctt      780

aatgctcgcc tgcccctgaa cactgatgcc tacttgtccc tccaagaact ccagggtcag      840

gacccaactc acttggtg                                                    858


<210>  595
<211>  540
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Synthetic nucleotide

<400>  595
atgggaatga agacaccaca gctggaacaa tcagtggatt atagacataa gttctccttg       60

cctagtgtgg atgggcagaa acgctacacg tttcgtgttc ggagccgctt taacccactc      120

tgtggaagtg ctcagcattg gagtgaatgg agccacccaa tccactgggg gagcaatact      180

tcaaaagaga atcctttcct gtttgcattg gaagccgtgg ttatctctgt tggctccatg      240

ggattgatta tcagccttct ctgtgtgtat ttctggctgg aacggacgat gccccgaatt      300

cccaccctga agaacctaga ggatcttgtt actgaatacc acgggaactt ttcggcctgg      360

agtggtgtgt ctaagggact ggctgagagt ctgcagccag actacagtga acgactctgc      420

ctcgtcagtg agattccccc aaaaggaggg gcccttgggg aggggcctgg ggcctcccca      480

tgcaaccagc atagccccta ctgggccccc ccatgttaca ccctaaagcc tgaaacctga      540


<210>  596
<211>  573
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Synthetic nucleotide

<400>  596
tatagagttg acttggttct attttataga catttaacga gaagagatga aacattaaca       60

gatggaaaaa catatgatgc ttttgtgtct tacctaaaag aatgccgacc tgaaaatgga      120

gaggagcaca cctttgctgt ggagattttg cccagggtgt tggagaaaca ttttgggtat      180

aagttatgca tatttgaaag ggatgtagtg cctggaggag ctgttgttga tgaaatccac      240

tcactgatag agaaaagccg aagactaatc attgtcctaa gtaaaagtta tatgtctaat      300

gaggtcaggt atgaacttga aagtggactc catgaagcat tggtggaaag aaaaattaaa      360

ataatcttaa ttgaatttac acctgttact gacttcacat tcttgcccca atcactaaag      420

cttttgaaat ctcacagagt tctgaagtgg aaggccgata aatctctttc ttataactca      480

aggttctgga agaaccttct ttacttaatg cctgcaaaaa cagtcaagcc aggtagagac      540

gaaccggaag tcttgcctgt tctttccgag tct                                   573


<210>  597
<211>  585
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Synthetic nucleotide

<400>  597
aaaaaacgca ttaaaccgat tgtgtggccg agcctgccgg atcataaaaa aaccctggaa       60

catctgtgca aaaaaccgcg caaaaacctg aacgtgagct ttaacccgga aagctttctg      120

gattgccaga ttcatcgcgt ggatgatatt caggcgcgcg atgaagtgga aggctttctg      180

caggatacct ttccgcagca gctggaagaa agcgaaaaac agcgcctggg cggcgatgtg      240

cagagcccga actgcccgag cgaagatgtg gtgattaccc cggaaagctt tggccgcgat      300

agcagcctga cctgcctggc gggcaacgtg agcgcgtgcg atgcgccgat tctgagcagc      360

agccgcagcc tggattgccg cgaaagcggc aaaaacggcc cgcatgtgta tcaggatctg      420

ctgctgagcc tgggcaccac caacagcacc ctgccgccgc cgtttagcct gcagagcggc      480

attctgaccc tgaacccggt ggcgcagggc cagccgattc tgaccagcct gggcagcaac      540

caggaagaag cgtatgtgac catgagcagc ttttatcaga accag                      585


<210>  598
<211>  276
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Synthetic nucleotide

<400>  598
aaccgcgcgg cgcgccatct gtgcccgccg ctgccgaccc cgtgcgcgag cagcgcgatt       60

gaatttccgg gcggcaaaga aacctggcag tggattaacc cggtggattt tcaggaagaa      120

gcgagcctgc aggaagcgct ggtggtggaa atgagctggg ataaaggcga acgcaccgaa      180

ccgctggaaa aaaccgaact gccggaaggc gcgccggaac tggcgctgga taccgaactg      240

agcctggaag atggcgatcg ctgcaaagcg aaaatg                                276


<210>  599
<211>  657
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Synthetic nucleotide

<400>  599
cattattttc agcagaaagt gtttgtgctg ctggcggcgc tgcgcccgca gtggtgcagc       60

cgcgaaattc cggatccggc gaacagcacc tgcgcgaaaa aatatccgat tgcggaagaa      120

aaaacccagc tgccgctgga tcgcctgctg attgattggc cgaccccgga agatccggaa      180

ccgctggtga ttagcgaagt gctgcatcag gtgaccccgg tgtttcgcca tccgccgtgc      240

agcaactggc cgcagcgcga aaaaggcatt cagggccatc aggcgagcga aaaagatatg      300

atgcatagcg cgagcagccc gccgccgccg cgcgcgctgc aggcggaaag ccgccagctg      360

gtggatctgt ataaagtgct ggaaagccgc ggcagcgatc cgaaaccgga aaacccggcg      420

tgcccgtgga ccgtgctgcc ggcgggcgat ctgccgaccc atgatggcta tctgccgagc      480

aacattgatg atctgccgag ccatgaagcg ccgctggcgg atagcctgga agaactggaa      540

ccgcagcata ttagcctgag cgtgtttccg agcagcagcc tgcatccgct gacctttagc      600

tgcggcgata aactgaccct ggatcagctg aaaatgcgct gcgatagcct gatgctg         657


<210>  600
<211>  117
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Synthetic nucleotide

<400>  600
aaaagccgcc agaccccgcc gctggcgagc gtggaaatgg aagcgatgga agcgctgccg       60

gtgacctggg gcaccagcag ccgcgatgaa gatctggaaa actgcagcca tcatctg         117


<210>  601
<211>  855
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Synthetic nucleotide

<400>  601
agcctgaaaa cccatccgct gtggcgcctg tggaaaaaaa tttgggcggt gccgagcccg       60

gaacgctttt ttatgccgct gtataaaggc tgcagcggcg attttaaaaa atgggtgggc      120

gcgccgttta ccggcagcag cctggaactg ggcccgtgga gcccggaagt gccgagcacc      180

ctggaagtgt atagctgcca tccgccgcgc agcccggcga aacgcctgca gctgaccgaa      240

ctgcaggaac cggcggaact ggtggaaagc gatggcgtgc cgaaaccgag cttttggccg      300

accgcgcaga acagcggcgg cagcgcgtat agcgaagaac gcgatcgccc gtatggcctg      360

gtgagcattg ataccgtgac cgtgctggat gcggaaggcc cgtgcacctg gccgtgcagc      420

tgcgaagatg atggctatcc ggcgctggat ctggatgcgg gcctggaacc gagcccgggc      480

ctggaagatc cgctgctgga tgcgggcacc accgtgctga gctgcggctg cgtgagcgcg      540

ggcagcccgg gcctgggcgg cccgctgggc agcctgctgg atcgcctgaa accgccgctg      600

gcggatggcg aagattgggc gggcggcctg ccgtggggcg gccgcagccc gggcggcgtg      660

agcgaaagcg aagcgggcag cccgctggcg ggcctggata tggatacctt tgatagcggc      720

tttgtgggca gcgattgcag cagcccggtg gaatgcgatt ttaccagccc gggcgatgaa      780

ggcccgccgc gcagctatct gcgccagtgg gtggtgattc cgccgccgct gagcagcccg      840

ggcccgcagg cgagc                                                       855


<210>  602
<211>  660
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Synthetic nucleotide

<400>  602
ccgctgccgc cggaaatgag cggcaccatg ctgatgctgg cggtgctgct gccgctggcg       60

ttttttctgc tgctggcgac cgtgtttagc tgcatttgga aaagccatcc gagcctgtgc      120

cgcaaactgg gcagcctgct gaaacgccgc ccgcagggcg aaggcccgaa cccggtggcg      180

ggcagctggg aaccgccgaa agcgcatccg tattttccgg atctggtgca gccgctgctg      240

ccgattagcg gcgatgtgag cccggtgagc accggcctgc cggcggcgcc ggtgctggaa      300

gcgggcgtgc cgcagcagca gagcccgctg gatctgaccc gcgaaccgca gctggaaccg      360

ggcgaacaga gccaggtggc gcatggcacc aacggcattc atgtgaccgg cggcagcatg      420

accattaccg gcaacattta tatttataac ggcccggtgc tgggcggccc gccgggcccg      480

ggcgatctgc cggcgacccc ggaaccgccg tatccgattc cggaagaagg cgatccgggc      540

ccgccgggcc tgagcacccc gcatcaggaa gatggcaaag cgtggcatct ggcggaaacc      600

gaacattgcg gcgcgacccc gagcaaccgc ggcccgcgca accagtttat tacccatgat      660


<210>  603
<211>  30
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Synthetic nucleotide

<400>  603
ggtggcggag gttctggagg tggaggttcc                                        30


<210>  604
<211>  1183
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Synthetic nucleotide

<400>  604
gtgaggctcc ggtgcccgtc agtgggcaga gcgcacatcg cccacagtcc ccgagaagtt       60

ggggggaggg gtcggcaatt gaaccggtgc ctagagaagg tggcgcgggg taaactggga      120

aagtgatgtc gtgtactggc tccgcctttt tcccgagggt gggggagaac cgtatataag      180

tgcagtagtc gccgtgaacg ttctttttcg caacgggttt gccgccagaa cacaggtaag      240

tgccgtgtgt ggttcccgcg ggcctggcct ctttacgggt tatggccctt gcgtgccttg      300

aattacttcc acctggctgc agtacgtgat tcttgatccc gagcttcggg ttggaagtgg      360

gtgggagagt tcgaggcctt gcgcttaagg agccccttcg cctcgtgctt gagttgaggc      420

ctggcctggg cgctggggcc gccgcgtgcg aatctggtgg caccttcgcg cctgtctcgc      480

tgctttcgat aagtctctag ccatttaaaa tttttgatga cctgctgcga cgcttttttt      540

ctggcaagat agtcttgtaa atgcgggcca agatctgcac actggtattt cggtttttgg      600

ggccgcgggc ggcgacgggg cccgtgcgtc ccagcgcaca tgttcggcga ggcggggcct      660

gcgagcgcgg ccaccgagaa tcggacgggg gtagtctcaa gctggccggc ctgctctggt      720

gcctggcctc gcgccgccgt gtatcgcccc gccctgggcg gcaaggctgg cccggtcggc      780

accagttgcg tgagcggaaa gatggccgct tcccggccct gctgcaggga gctcaaaatg      840

gaggacgcgg cgctcgggag agcgggcggg tgagtcaccc acacaaagga aaagggcctt      900

tccgtcctca gccgtcgctt catgtgactc cacggagtac cgggcgccgt ccaggcacct      960

cgattagttc tcgagctttt ggagtacgtc gtctttaggt tggggggagg ggttttatgc     1020

gatggagttt ccccacactg agtgggtgga gactgaagtt aggccagctt ggcacttgat     1080

gtaattctcc ttggaatttg ccctttttga gtttggatct tggttcattc tcaagcctca     1140

gacagtggtt caaagttttt ttcttccatt tcaggtgtcg tga                       1183


<210>  605
<211>  508
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Synthetic nucleotide

<400>  605
cgttacataa cttacggtaa atggcccgcc tggctgaccg cccaacgacc cccgcccatt       60

gacgtcaata atgacgtatg ttcccatagt aacgccaata gggactttcc attgacgtca      120

atgggtggag tatttacggt aaactgccca cttggcagta catcaagtgt atcatatgcc      180

aagtacgccc cctattgacg tcaatgacgg taaatggccc gcctggcatt atgcccagta      240

catgacctta tgggactttc ctacttggca gtacatctac gtattagtca tcgctattac      300

catggtgatg cggttttggc agtacatcaa tgggcgtgga tagcggtttg actcacgggg      360

atttccaagt ctccacccca ttgacgtcaa tgggagtttg ttttggcacc aaaatcaacg      420

ggactttcca aaatgtcgta acaactccgc cccattgacg caaatgggcg gtaggcgtgt      480

acggtgggag gtctatataa gcagagct                                         508


<210>  606
<211>  515
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Synthetic nucleotide

<400>  606
tgaaagaccc cacctgtagg tttggcaagc tagcttaagt aacgccattt tgcaaggcat       60

ggaaaataca taactgagaa tagagaagtt cagatcaagg ttaggaacag agagacagca      120

gaatatgggc caaacaggat atctgtggta agcagttcct gccccggctc agggccaaga      180

acagatggtc cccagatgcg gtcccgccct cagcagtttc tagagaacca tcagatgttt      240

ccagggtgcc ccaaggacct gaaatgaccc tgtgccttat ttgaactaac caatcagttc      300

gcttctcgct tctgttcgcg cgcttctgct ccccgagctc aataaaagag cccacaaccc      360

ctcactcggc gcgccagtcc tccgatagac tgcgtcgccc gggtacccgt attcccaata      420

aagcctcttg ctgtttgcat ccgaatcgtg gactcgctga tccttgggag ggtctcctca      480

gattgattga ctgcccacct cgggggtctt tcatt                                 515


<210>  607
<211>  390
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Synthetic nucleotide

<400>  607
tcgaggtcga cggtatcgat aagcttgata tcgaattagg aggaaaaact gtttcataca       60

gaaggcgtca attaggagga aaaactgttt catacagaag gcgtcaatta ggaggaaaaa      120

ctgtttcata cagaaggcgt caattggtcc catcgaatta ggaggaaaaa ctgtttcata      180

cagaaggcgt caattaggag gaaaaactgt ttcatacaga aggcgtcaat taggaggaaa      240

aactgtttca tacagaaggc gtcaattggt cccgggacat tttgacaccc ccataatatt      300

tttccagaat taacagtata aattgcatct cttgttcaag agttccctat cactctcttt      360

aatcactact cacagtaacc tcaactcctg                                       390


<210>  608
<211>  18
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic amino acid

<400>  608

Glu Gly Arg Gly Ser Leu Leu Thr Cys Gly Asp Val Glu Glu Asn Pro 
1               5                   10                  15      


Gly Pro 
        


<210>  609
<211>  19
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic amino acid

<400>  609

Ala Thr Asn Phe Ser Leu Leu Lys Gln Ala Gly Asp Val Glu Glu Asn 
1               5                   10                  15      


Pro Gly Pro 
            


<210>  610
<211>  20
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic amino acid

<400>  610

Gln Cys Thr Asn Tyr Ala Leu Leu Lys Leu Ala Gly Asp Val Glu Ser 
1               5                   10                  15      


Asn Pro Gly Pro 
            20  


<210>  611
<211>  22
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic amino acid

<400>  611

Val Lys Gln Thr Leu Asn Phe Asp Leu Leu Lys Leu Ala Gly Asp Val 
1               5                   10                  15      


Glu Ser Asn Pro Gly Pro 
            20          


<210>  612
<211>  3
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic amino acid

<400>  612

Gly Ser Gly 
1           


<210>  613
<211>  63
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Synthetic nucleotide

<400>  613
ggaagcggag agggcagggg aagtcttcta acatgcgggg acgtggagga aaatcccggc       60

ccc                                                                     63


<210>  614
<211>  66
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Synthetic nucleotide

<400>  614
ggaagcggag ccacgaactt ctctctgtta aagcaagcag gagatgttga agaaaacccc       60

gggcct                                                                  66


<210>  615
<211>  69
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Synthetic nucleotide

<400>  615
ggaagcggac agtgtactaa ttatgctctc ttgaaattgg ctggagatgt tgagagcaac       60

ccaggtccc                                                               69


<210>  616
<211>  75
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Synthetic nucleotide

<400>  616
ggaagcggag tgaaacagac tttgaatttt gaccttctga agttggcagg agacgttgag       60

tccaaccctg ggccc                                                        75


<210>  617
<211>  588
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Synthetic nucleotide

<400>  617
gcccctctcc ctcccccccc cctaacgtta ctggccgaag ccgcttggaa taaggccggt       60

gtgcgtttgt ctatatgtta ttttccacca tattgccgtc ttttggcaat gtgagggccc      120

ggaaacctgg ccctgtcttc ttgacgagca ttcctagggg tctttcccct ctcgccaaag      180

gaatgcaagg tctgttgaat gtcgtgaagg aagcagttcc tctggaagct tcttgaagac      240

aaacaacgtc tgtagcgacc ctttgcaggc agcggaaccc cccacctggc gacaggtgcc      300

tctgcggcca aaagccacgt gtataagata cacctgcaaa ggcggcacaa ccccagtgcc      360

acgttgtgag ttggatagtt gtggaaagag tcaaatggct ctcctcaagc gtattcaaca      420

aggggctgaa ggatgcccag aaggtacccc attgtatggg atctgatctg gggcctcggt      480

gcacatgctt tacatgtgtt tagtcgaggt taaaaaaacg tctaggcccc ccgaaccacg      540

gggacgtggt tttcctttga aaaacacgat gataatatgg ccacaacc                   588


<210>  618
<211>  9600
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Synthetic nucleotide

<400>  618
aatgtagtct tatgcaatac tcttgtagtc ttgcaacatg gtaacgatga gttagcaaca       60

tgccttacaa ggagagaaaa agcaccgtgc atgccgattg gtggaagtaa ggtggtacga      120

tcgtgcctta ttaggaaggc aacagacggg tctgacatgg attggacgaa ccactgaatt      180

gccgcattgc agagatattg tatttaagtg cctagctcga tacataaacg ggtctctctg      240

gttagaccag atctgagcct gggagctctc tggctaacta gggaacccac tgcttaagcc      300

tcaataaagc ttgccttgag tgcttcaagt agtgtgtgcc cgtctgttgt gtgactctgg      360

taactagaga tccctcagac ccttttagtc agtgtggaaa atctctagca gtggcgcccg      420

aacagggact tgaaagcgaa agggaaacca gaggagctct ctcgacgcag gactcggctt      480

gctgaagcgc gcacggcaag aggcgagggg cggcgactgg tgagtacgcc aaaaattttg      540

actagcggag gctagaagga gagagatggg tgcgagagcg tcagtattaa gcgggggaga      600

attagatcgc gatgggaaaa aattcggtta aggccagggg gaaagaaaaa atataaatta      660

aaacatatag tatgggcaag cagggagcta gaacgattcg cagttaatcc tggcctgtta      720

gaaacatcag aaggctgtag acaaatactg ggacagctac aaccatccct tcagacagga      780

tcagaagaac ttagatcatt atataataca gtagcaaccc tctattgtgt gcatcaaagg      840

atagagataa aagacaccaa ggaagcttta gacaagatag aggaagagca aaacaaaagt      900

aagaccaccg cacagcaagc ggccgctgat cttcagacct ggaggaggag atatgaggga      960

caattggaga agtgaattat ataaatataa agtagtaaaa attgaaccat taggagtagc     1020

acccaccaag gcaaagagaa gagtggtgca gagagaaaaa agagcagtgg gaataggagc     1080

tttgttcctt gggttcttgg gagcagcagg aagcactatg ggcgcagcgt caatgacgct     1140

gacggtacag gccagacaat tattgtctgg tatagtgcag cagcagaaca atttgctgag     1200

ggctattgag gcgcaacagc atctgttgca actcacagtc tggggcatca agcagctcca     1260

ggcaagaatc ctggctgtgg aaagatacct aaaggatcaa cagctcctgg ggatttgggg     1320

ttgctctgga aaactcattt gcaccactgc tgtgccttgg aatgctagtt ggagtaataa     1380

atctctggaa cagatttgga atcacacgac ctggatggag tgggacagag aaattaacaa     1440

ttacacaagc ttaatacact ccttaattga agaatcgcaa aaccagcaag aaaagaatga     1500

acaagaatta ttggaattag ataaatgggc aagtttgtgg aattggttta acataacaaa     1560

ttggctgtgg tatataaaat tattcataat gatagtagga ggcttggtag gtttaagaat     1620

agtttttgct gtactttcta tagtgaatag agttaggcag ggatattcac cattatcgtt     1680

tcagacccac ctcccaaccc cgaggggacc cgacaggccc gaaggaatag aagaagaagg     1740

tggagagaga gacagagaca gatccattcg attagtgaac ggatctcgac ggtatcgcta     1800

gcttttaaaa gaaaaggggg gattgggggg tacagtgcag gggaaagaat agtagacata     1860

atagcaacag acatacaaac taaagaatta caaaaacaaa ttacaaaaat tcaaaatttt     1920

actagtgatt atcggatcaa ctttgtatag aaaagttggg ctccggtgcc cgtcagtggg     1980

cagagcgcac atcgcccaca gtccccgaga agttgggggg aggggtcggc aattgaaccg     2040

gtgcctagag aaggtggcgc ggggtaaact gggaaagtga tgtcgtgtac tggctccgcc     2100

tttttcccga gggtggggga gaaccgtata taagtgcagt agtcgccgtg aacgttcttt     2160

ttcgcaacgg gtttgccgcc agaacacagg taagtgccgt gtgtggttcc cgcgggcctg     2220

gcctctttac gggttatggc ccttgcgtgc cttgaattac ttccacctgg ctgcagtacg     2280

tgattcttga tcccgagctt cgggttggaa gtgggtggga gagttcgagg ccttgcgctt     2340

aaggagcccc ttcgcctcgt gcttgagttg aggcctggcc tgggcgctgg ggccgccgcg     2400

tgcgaatctg gtggcacctt cgcgcctgtc tcgctgcttt cgataagtct ctagccattt     2460

aaaatttttg atgacctgct gcgacgcttt ttttctggca agatagtctt gtaaatgcgg     2520

gccaagatct gcacactggt atttcggttt ttggggccgc gggcggcgac ggggcccgtg     2580

cgtcccagcg cacatgttcg gcgaggcggg gcctgcgagc gcggccaccg agaatcggac     2640

gggggtagtc tcaagctggc cggcctgctc tggtgcctgg tctcgcgccg ccgtgtatcg     2700

ccccgccctg ggcggcaagg ctggcccggt cggcaccagt tgcgtgagcg gaaagatggc     2760

cgcttcccgg ccctgctgca gggagctcaa aatggaggac gcggcgctcg ggagagcggg     2820

cgggtgagtc acccacacaa aggaaaaggg cctttccgtc ctcagccgtc gcttcatgtg     2880

actccacgga gtaccgggcg ccgtccaggc acctcgatta gttctcgagc ttttggagta     2940

cgtcgtcttt aggttggggg gaggggtttt atgcgatgga gtttccccac actgagtggg     3000

tggagactga agttaggcca gcttggcact tgatgtaatt ctccttggaa tttgcccttt     3060

ttgagtttgg atcttggttc attctcaagc ctcagacagt ggttcaaagt ttttttcttc     3120

catttcaggt gtcgtgacaa gtttgtacaa aaaagcaggc tgccaccatg gagatcgtgc     3180

tgacccaaag tccagccacc ctttccctgt ctccaggcga acgcgcaacc ctgagctgcc     3240

gcgcttctca gaccattggt acctccattc attggtatca gcagaagccc ggccaagccc     3300

cgcgtctgct gatctattac gcctcagaaa gtatttcagg catccccgct cgcttctccg     3360

gctccggcag cggaaccgac ttcacactta caatctctag tttggagcca gaagacttcg     3420

ccgtttacta ctgtcagcag tctaacagct ggccatttac ctttggccag ggcacgaagc     3480

tggaaatcaa gggcggcggc ggcagcggcg gcggcggcag cggcggcggc ggcagccagg     3540

tgcagttggt tcagagcggc gcggaagtca agaaacccgg cgcctccgtg aaagtgagct     3600

gcaaagcgag cggctacacc ttcaccagtt attggattaa ctgggtgcgc caggccccag     3660

gccaggggct ggagtggatg ggaaacatct acccatctga ctcttacagc aactataatc     3720

agaaatttaa ggatcgcgta acaatgaccc gtgacaccag caccagcact gtttacatgg     3780

agctgagttc tctgcgttct gaagataccg ccgtgtacta ctgcgcacgc ggttccagtt     3840

tcgattactg gggccagggg accctggtca ccgtctcctc agagagcaag tacggccctc     3900

cctgcccccc ttgccctgcc cccgagttcc tgggcggacc cagcgtgttc ctgttccccc     3960

ccaagcccaa ggacaccctg atgatcagcc ggacccccga ggtgacctgt gtggtggtgg     4020

acgtgtccca ggaggacccc gaggtccagt tcaactggta cgtggacggc gtggaggtgc     4080

acaacgccaa gaccaagccc cgggaggagc agttcaatag cacctaccgg gtggtgtccg     4140

tgctgaccgt gctgcaccag gactggctga acggcaagga atacaagtgt aaggtgtcca     4200

acaagggcct gcccagcagc atcgagaaaa ccatcagcaa ggccaagggc cagcctcggg     4260

agccccaggt gtacaccctg ccccctagcc aagaggagat gaccaagaac caggtgtccc     4320

tgacctgcct ggtgaagggc ttctacccca gcgacatcgc cgtggagtgg gagagcaacg     4380

gccagcccga gaacaactac aagaccaccc cccctgtgct ggacagcgac ggcagcttct     4440

tcctgtacag ccggctgacc gtggacaaga gccggtggca ggagggcaac gtctttagct     4500

gctccgtgat gcacgaggcc ctgcacaacc actacaccca gaagagcctg agcctgtccc     4560

tgggcaagat gaactgcagg aacaccgggc catggctgaa gaaggtcctg aagtgtaaca     4620

ccccagaccc ctcgaagttc ttttcccagc tgagctcaga gcatggagga gacgtccaga     4680

agtggctctc ttcgcccttc ccctcatcgt ccttcagccc tggcggcctg gcacctgaga     4740

tctcgccact agaagtgctg gagagggaca aggtgacgca gctgctcctg cagcaggaca     4800

aggtgcctga gcccgcatcc ttaagcagca accactcgct gaccagctgc ttcaccaacc     4860

agggttactt cttcttccac ctcccggatg ccttggagat agaggcctgc caggtgtact     4920

ttacttacga cccctactca gaggaagacc ctgatgaggg tgtggccggg gcacccacag     4980

ggtcttcccc ccaacccctg cagcctctgt caggggagga cgacgcctac tgcaccttcc     5040

cctccaggga tgacctgctg ctcttctccc ccagtctcct cggtggcccc agccccccaa     5100

gcactgcccc tgggggcagt ggggccggtg aagagaggat gcccccttct ttgcaagaaa     5160

gagtccccag agactgggac ccccagcccc tggggcctcc caccccagga gtcccagacc     5220

tggtggattt tcagccaccc cctgagctgg tgctgcgaga ggctggggag gaggtccctg     5280

acgctggccc cagggaggga gtcagtttcc cctggtccag gcctcctggg cagggggagt     5340

tcagggccct taatgctcgc ctgcccctga acactgatgc ctacttgtcc ctccaagaac     5400

tccagggtca ggacccaact cacttggtgt aaacccagct ttcttgtaca aagtggtgat     5460

aatcgaattc cgataatcaa cctctggatt acaaaatttg tgaaagattg actggtattc     5520

ttaactatgt tgctcctttt acgctatgtg gatacgctgc tttaatgcct ttgtatcatg     5580

ctattgcttc ccgtatggct ttcattttct cctccttgta taaatcctgg ttgctgtctc     5640

tttatgagga gttgtggccc gttgtcaggc aacgtggcgt ggtgtgcact gtgtttgctg     5700

acgcaacccc cactggttgg ggcattgcca ccacctgtca gctcctttcc gggactttcg     5760

ctttccccct ccctattgcc acggcggaac tcatcgccgc ctgccttgcc cgctgctgga     5820

caggggctcg gctgttgggc actgacaatt ccgtggtgtt gtcggggaag ctgacgtcct     5880

ttccatggct gctcgcctgt gttgccacct ggattctgcg cgggacgtcc ttctgctacg     5940

tcccttcggc cctcaatcca gcggaccttc cttcccgcgg cctgctgccg gctctgcggc     6000

ctcttccgcg tcttcgcctt cgccctcaga cgagtcggat ctccctttgg gccgcctccc     6060

cgcatcggga attcccgcgg ttcgctttaa gaccaatgac ttacaaggca gctgtagatc     6120

ttagccactt tttaaaagaa aaggggggac tggaagggct aattcactcc caacgaagac     6180

aagatctgct ttttgcttgt actgggtctc tctggttaga ccagatctga gcctgggagc     6240

tctctggcta actagggaac ccactgctta agcctcaata aagcttgcct tgagtgcttc     6300

aagtagtgtg tgcccgtctg ttgtgtgact ctggtaacta gagatccctc agaccctttt     6360

agtcagtgtg gaaaatctct agcagtagta gttcatgtca tcttattatt cagtatttat     6420

aacttgcaaa gaaatgaata tcagagagtg agaggaactt gtttattgca gcttataatg     6480

gttacaaata aagcaatagc atcacaaatt tcacaaataa agcatttttt tcactgcatt     6540

ctagttgtgg tttgtccaaa ctcatcaatg tatcttatca tgtctggctc tagctatccc     6600

gcccctaact ccgcccatcc cgcccctaac tccgcccagt tccgcccatt ctccgcccca     6660

tggctgacta atttttttta tttatgcaga ggccgaggcc gcctcggcct ctgagctatt     6720

ccagaagtag tgaggaggct tttttggagg cctagggacg tacccaattc gccctatagt     6780

gagtcgtatt acgcgcgctc actggccgtc gttttacaac gtcgtgactg ggaaaaccct     6840

ggcgttaccc aacttaatcg ccttgcagca catccccctt tcgccagctg gcgtaatagc     6900

gaagaggccc gcaccgatcg cccttcccaa cagttgcgca gcctgaatgg cgaatgggac     6960

gcgccctgta gcggcgcatt aagcgcggcg ggtgtggtgg ttacgcgcag cgtgaccgct     7020

acacttgcca gcgccctagc gcccgctcct ttcgctttct tcccttcctt tctcgccacg     7080

ttcgccggct ttccccgtca agctctaaat cgggggctcc ctttagggtt ccgatttagt     7140

gctttacggc acctcgaccc caaaaaactt gattagggtg atggttcacg tagtgggcca     7200

tcgccctgat agacggtttt tcgccctttg acgttggagt ccacgttctt taatagtgga     7260

ctcttgttcc aaactggaac aacactcaac cctatctcgg tctattcttt tgatttataa     7320

gggattttgc cgatttcggc ctattggtta aaaaatgagc tgatttaaca aaaatttaac     7380

gcgaatttta acaaaatatt aacgcttaca atttaggtgg cacttttcgg ggaaatgtgc     7440

gcggaacccc tatttgttta tttttctaaa tacattcaaa tatgtatccg ctcatgagac     7500

aataaccctg ataaatgctt caataatatt gaaaaaggaa gagtatgagt attcaacatt     7560

tccgtgtcgc ccttattccc ttttttgcgg cattttgcct tcctgttttt gctcacccag     7620

aaacgctggt gaaagtaaaa gatgctgaag atcagttggg tgcacgagtg ggttacatcg     7680

aactggatct caacagcggt aagatccttg agagttttcg ccccgaagaa cgttttccaa     7740

tgatgagcac ttttaaagtt ctgctatgtg gcgcggtatt atcccgtatt gacgccgggc     7800

aagagcaact cggtcgccgc atacactatt ctcagaatga cttggttgag tactcaccag     7860

tcacagaaaa gcatcttacg gatggcatga cagtaagaga attatgcagt gctgccataa     7920

ccatgagtga taacactgcg gccaacttac ttctgacaac gatcggagga ccgaaggagc     7980

taaccgcttt tttgcacaac atgggggatc atgtaactcg ccttgatcgt tgggaaccgg     8040

agctgaatga agccatacca aacgacgagc gtgacaccac gatgcctgta gcaatggcaa     8100

caacgttgcg caaactatta actggcgaac tacttactct agcttcccgg caacaattaa     8160

tagactggat ggaggcggat aaagttgcag gaccacttct gcgctcggcc cttccggctg     8220

gctggtttat tgctgataaa tctggagccg gtgagcgtgg gtctcgcggt atcattgcag     8280

cactggggcc agatggtaag ccctcccgta tcgtagttat ctacacgacg gggagtcagg     8340

caactatgga tgaacgaaat agacagatcg ctgagatagg tgcctcactg attaagcatt     8400

ggtaactgtc agaccaagtt tactcatata tactttagat tgatttaaaa cttcattttt     8460

aatttaaaag gatctaggtg aagatccttt ttgataatct catgaccaaa atcccttaac     8520

gtgagttttc gttccactga gcgtcagacc ccgtagaaaa gatcaaagga tcttcttgag     8580

atcctttttt tctgcgcgta atctgctgct tgcaaacaaa aaaaccaccg ctaccagcgg     8640

tggtttgttt gccggatcaa gagctaccaa ctctttttcc gaaggtaact ggcttcagca     8700

gagcgcagat accaaatact gttcttctag tgtagccgta gttaggccac cacttcaaga     8760

actctgtagc accgcctaca tacctcgctc tgctaatcct gttaccagtg gctgctgcca     8820

gtggcgataa gtcgtgtctt accgggttgg actcaagacg atagttaccg gataaggcgc     8880

agcggtcggg ctgaacgggg ggttcgtgca cacagcccag cttggagcga acgacctaca     8940

ccgaactgag atacctacag cgtgagctat gagaaagcgc cacgcttccc gaagagagaa     9000

aggcggacag gtatccggta agcggcaggg tcggaacagg agagcgcacg agggagcttc     9060

cagggggaaa cgcctggtat ctttatagtc ctgtcgggtt tcgccacctc tgacttgagc     9120

gtcgattttt gtgatgctcg tcaggggggc ggagcctatg gaaaaacgcc agcaacgcgg     9180

cctttttacg gttcctggcc ttttgctggc cttttgctca catgttcttt cctgcgttat     9240

cccctgattc tgtggataac cgtattaccg cctttgagtg agctgatacc gctcgccgca     9300

gccgaacgac cgagcgcagc gagtcagtga gcgaggaagc ggaagagcgc ccaatacgca     9360

aaccgcctct ccccgcgcgt tggccgattc attaatgcag ctggcacgac aggtttcccg     9420

actggaaagc gggcagtgag cgcaacgcaa ttaatgtgag ttagctcact cattaggcac     9480

cccaggcttt acactttatg cttccggctc gtatgttgtg tggaattgtg agcggataac     9540

aatttcacac aggaaacagc tatgaccatg attacgccaa gcgcgcaatt aaccctcact     9600


<210>  619
<211>  8907
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Synthetic nucleotide

<400>  619
aatgtagtct tatgcaatac tcttgtagtc ttgcaacatg gtaacgatga gttagcaaca       60

tgccttacaa ggagagaaaa agcaccgtgc atgccgattg gtggaagtaa ggtggtacga      120

tcgtgcctta ttaggaaggc aacagacggg tctgacatgg attggacgaa ccactgaatt      180

gccgcattgc agagatattg tatttaagtg cctagctcga tacataaacg ggtctctctg      240

gttagaccag atctgagcct gggagctctc tggctaacta gggaacccac tgcttaagcc      300

tcaataaagc ttgccttgag tgcttcaagt agtgtgtgcc cgtctgttgt gtgactctgg      360

taactagaga tccctcagac ccttttagtc agtgtggaaa atctctagca gtggcgcccg      420

aacagggact tgaaagcgaa agggaaacca gaggagctct ctcgacgcag gactcggctt      480

gctgaagcgc gcacggcaag aggcgagggg cggcgactgg tgagtacgcc aaaaattttg      540

actagcggag gctagaagga gagagatggg tgcgagagcg tcagtattaa gcgggggaga      600

attagatcgc gatgggaaaa aattcggtta aggccagggg gaaagaaaaa atataaatta      660

aaacatatag tatgggcaag cagggagcta gaacgattcg cagttaatcc tggcctgtta      720

gaaacatcag aaggctgtag acaaatactg ggacagctac aaccatccct tcagacagga      780

tcagaagaac ttagatcatt atataataca gtagcaaccc tctattgtgt gcatcaaagg      840

atagagataa aagacaccaa ggaagcttta gacaagatag aggaagagca aaacaaaagt      900

aagaccaccg cacagcaagc ggccgctgat cttcagacct ggaggaggag atatgaggga      960

caattggaga agtgaattat ataaatataa agtagtaaaa attgaaccat taggagtagc     1020

acccaccaag gcaaagagaa gagtggtgca gagagaaaaa agagcagtgg gaataggagc     1080

tttgttcctt gggttcttgg gagcagcagg aagcactatg ggcgcagcgt caatgacgct     1140

gacggtacag gccagacaat tattgtctgg tatagtgcag cagcagaaca atttgctgag     1200

ggctattgag gcgcaacagc atctgttgca actcacagtc tggggcatca agcagctcca     1260

ggcaagaatc ctggctgtgg aaagatacct aaaggatcaa cagctcctgg ggatttgggg     1320

ttgctctgga aaactcattt gcaccactgc tgtgccttgg aatgctagtt ggagtaataa     1380

atctctggaa cagatttgga atcacacgac ctggatggag tgggacagag aaattaacaa     1440

ttacacaagc ttaatacact ccttaattga agaatcgcaa aaccagcaag aaaagaatga     1500

acaagaatta ttggaattag ataaatgggc aagtttgtgg aattggttta acataacaaa     1560

ttggctgtgg tatataaaat tattcataat gatagtagga ggcttggtag gtttaagaat     1620

agtttttgct gtactttcta tagtgaatag agttaggcag ggatattcac cattatcgtt     1680

tcagacccac ctcccaaccc cgaggggacc cgacaggccc gaaggaatag aagaagaagg     1740

tggagagaga gacagagaca gatccattcg attagtgaac ggatctcgac ggtatcgcta     1800

gcttttaaaa gaaaaggggg gattgggggg tacagtgcag gggaaagaat agtagacata     1860

atagcaacag acatacaaac taaagaatta caaaaacaaa ttacaaaaat tcaaaatttt     1920

actagtgatt atcggatcaa ctttgtatag aaaagttggg ctccggtgcc cgtcagtggg     1980

cagagcgcac atcgcccaca gtccccgaga agttgggggg aggggtcggc aattgaaccg     2040

gtgcctagag aaggtggcgc ggggtaaact gggaaagtga tgtcgtgtac tggctccgcc     2100

tttttcccga gggtggggga gaaccgtata taagtgcagt agtcgccgtg aacgttcttt     2160

ttcgcaacgg gtttgccgcc agaacacagg taagtgccgt gtgtggttcc cgcgggcctg     2220

gcctctttac gggttatggc ccttgcgtgc cttgaattac ttccacctgg ctgcagtacg     2280

tgattcttga tcccgagctt cgggttggaa gtgggtggga gagttcgagg ccttgcgctt     2340

aaggagcccc ttcgcctcgt gcttgagttg aggcctggcc tgggcgctgg ggccgccgcg     2400

tgcgaatctg gtggcacctt cgcgcctgtc tcgctgcttt cgataagtct ctagccattt     2460

aaaatttttg atgacctgct gcgacgcttt ttttctggca agatagtctt gtaaatgcgg     2520

gccaagatct gcacactggt atttcggttt ttggggccgc gggcggcgac ggggcccgtg     2580

cgtcccagcg cacatgttcg gcgaggcggg gcctgcgagc gcggccaccg agaatcggac     2640

gggggtagtc tcaagctggc cggcctgctc tggtgcctgg tctcgcgccg ccgtgtatcg     2700

ccccgccctg ggcggcaagg ctggcccggt cggcaccagt tgcgtgagcg gaaagatggc     2760

cgcttcccgg ccctgctgca gggagctcaa aatggaggac gcggcgctcg ggagagcggg     2820

cgggtgagtc acccacacaa aggaaaaggg cctttccgtc ctcagccgtc gcttcatgtg     2880

actccacgga gtaccgggcg ccgtccaggc acctcgatta gttctcgagc ttttggagta     2940

cgtcgtcttt aggttggggg gaggggtttt atgcgatgga gtttccccac actgagtggg     3000

tggagactga agttaggcca gcttggcact tgatgtaatt ctccttggaa tttgcccttt     3060

ttgagtttgg atcttggttc attctcaagc ctcagacagt ggttcaaagt ttttttcttc     3120

catttcaggt gtcgtgacaa gtttgtacaa aaaagcaggc tgccaccatg gatattgtga     3180

tgacccagag cccggatagc ctggcggtga gcctgggcga acgcgcgacc attaactgca     3240

aaagcagcca gagcctgctg tatagccgca accagaaaaa ctatctggcg tggtatcagc     3300

agaaaccggg ccagccgccg aaactgctga ttttttgggc gagcacccgc gaaagcggcg     3360

tgccggatcg ctttagcggc agcggctttg gcaccgattt taccctgacc attagcagcc     3420

tgcaggcgga agatgtggcg gtgtattatt gccagcagta ttttagctat ccgctgacct     3480

ttggccaggg caccaaagtg gaaattaaag gcggcggcgg cagcggcggc ggcggcagcg     3540

gcggcggcgg cagccaggtg cagctggtgc agagcggcgc ggaagtgaaa aaaccgggcg     3600

cgagcgtgaa agtgagctgc aaaaccagcc gctatacctt taccgaatat accattcatt     3660

gggtgcgcca ggcgccgggc cagcgcctgg aatggattgg cggcattaac ccgaacaacg     3720

gcattccgaa ctataaccag aaatttaaag gccgcgtgac cattaccgtg gataccagcg     3780

cgagcaccgc gtatatggaa ctgagcagcc tgcgcagcga agataccgcg gtgtattatt     3840

gcgcgcgccg ccgcattgcg tatggctatg atgaaggcca tgcgatggat tattggggcc     3900

agggcaccct ggtgaccgtg agcagcacca cgacgccagc gccgcgacca ccaacaccgg     3960

cgcccaccat cgcgtcgcag cccctgtccc tgcgcccaga ggcgtgccgg ccagcggcgg     4020

ggggcgcagt gcacacgagg gggctggact tcgcctgtga tatctacatc tgggcgccct     4080

tggccgggac ttgtggggtc cttctcctgt cactggttat caccctttac tgctatagag     4140

ttgacttggt tctattttat agacatttaa cgagaagaga tgaaacatta acagatggaa     4200

aaacatatga tgcttttgtg tcttacctaa aagaatgccg acctgaaaat ggagaggagc     4260

acacctttgc tgtggagatt ttgcccaggg tgttggagaa acattttggg tataagttat     4320

gcatatttga aagggatgta gtgcctggag gagctgttgt tgatgaaatc cactcactga     4380

tagagaaaag ccgaagacta atcattgtcc taagtaaaag ttatatgtct aatgaggtca     4440

ggtatgaact tgaaagtgga ctccatgaag cattggtgga aagaaaaatt aaaataatct     4500

taattgaatt tacacctgtt actgacttca cattcttgcc ccaatcacta aagcttttga     4560

aatctcacag agttctgaag tggaaggccg ataaatctct ttcttataac tcaaggttct     4620

ggaagaacct tctttactta atgcctgcaa aaacagtcaa gccaggtaga gacgaaccgg     4680

aagtcttgcc tgttctttcc gagtcttgaa cccagctttc ttgtacaaag tggtgataat     4740

cgaattccga taatcaacct ctggattaca aaatttgtga aagattgact ggtattctta     4800

actatgttgc tccttttacg ctatgtggat acgctgcttt aatgcctttg tatcatgcta     4860

ttgcttcccg tatggctttc attttctcct ccttgtataa atcctggttg ctgtctcttt     4920

atgaggagtt gtggcccgtt gtcaggcaac gtggcgtggt gtgcactgtg tttgctgacg     4980

caacccccac tggttggggc attgccacca cctgtcagct cctttccggg actttcgctt     5040

tccccctccc tattgccacg gcggaactca tcgccgcctg ccttgcccgc tgctggacag     5100

gggctcggct gttgggcact gacaattccg tggtgttgtc ggggaagctg acgtcctttc     5160

catggctgct cgcctgtgtt gccacctgga ttctgcgcgg gacgtccttc tgctacgtcc     5220

cttcggccct caatccagcg gaccttcctt cccgcggcct gctgccggct ctgcggcctc     5280

ttccgcgtct tcgccttcgc cctcagacga gtcggatctc cctttgggcc gcctccccgc     5340

atcgggaatt cccgcggttc gctttaagac caatgactta caaggcagct gtagatctta     5400

gccacttttt aaaagaaaag gggggactgg aagggctaat tcactcccaa cgaagacaag     5460

atctgctttt tgcttgtact gggtctctct ggttagacca gatctgagcc tgggagctct     5520

ctggctaact agggaaccca ctgcttaagc ctcaataaag cttgccttga gtgcttcaag     5580

tagtgtgtgc ccgtctgttg tgtgactctg gtaactagag atccctcaga cccttttagt     5640

cagtgtggaa aatctctagc agtagtagtt catgtcatct tattattcag tatttataac     5700

ttgcaaagaa atgaatatca gagagtgaga ggaacttgtt tattgcagct tataatggtt     5760

acaaataaag caatagcatc acaaatttca caaataaagc atttttttca ctgcattcta     5820

gttgtggttt gtccaaactc atcaatgtat cttatcatgt ctggctctag ctatcccgcc     5880

cctaactccg cccatcccgc ccctaactcc gcccagttcc gcccattctc cgccccatgg     5940

ctgactaatt ttttttattt atgcagaggc cgaggccgcc tcggcctctg agctattcca     6000

gaagtagtga ggaggctttt ttggaggcct agggacgtac ccaattcgcc ctatagtgag     6060

tcgtattacg cgcgctcact ggccgtcgtt ttacaacgtc gtgactggga aaaccctggc     6120

gttacccaac ttaatcgcct tgcagcacat ccccctttcg ccagctggcg taatagcgaa     6180

gaggcccgca ccgatcgccc ttcccaacag ttgcgcagcc tgaatggcga atgggacgcg     6240

ccctgtagcg gcgcattaag cgcggcgggt gtggtggtta cgcgcagcgt gaccgctaca     6300

cttgccagcg ccctagcgcc cgctcctttc gctttcttcc cttcctttct cgccacgttc     6360

gccggctttc cccgtcaagc tctaaatcgg gggctccctt tagggttccg atttagtgct     6420

ttacggcacc tcgaccccaa aaaacttgat tagggtgatg gttcacgtag tgggccatcg     6480

ccctgataga cggtttttcg ccctttgacg ttggagtcca cgttctttaa tagtggactc     6540

ttgttccaaa ctggaacaac actcaaccct atctcggtct attcttttga tttataaggg     6600

attttgccga tttcggccta ttggttaaaa aatgagctga tttaacaaaa atttaacgcg     6660

aattttaaca aaatattaac gcttacaatt taggtggcac ttttcgggga aatgtgcgcg     6720

gaacccctat ttgtttattt ttctaaatac attcaaatat gtatccgctc atgagacaat     6780

aaccctgata aatgcttcaa taatattgaa aaaggaagag tatgagtatt caacatttcc     6840

gtgtcgccct tattcccttt tttgcggcat tttgccttcc tgtttttgct cacccagaaa     6900

cgctggtgaa agtaaaagat gctgaagatc agttgggtgc acgagtgggt tacatcgaac     6960

tggatctcaa cagcggtaag atccttgaga gttttcgccc cgaagaacgt tttccaatga     7020

tgagcacttt taaagttctg ctatgtggcg cggtattatc ccgtattgac gccgggcaag     7080

agcaactcgg tcgccgcata cactattctc agaatgactt ggttgagtac tcaccagtca     7140

cagaaaagca tcttacggat ggcatgacag taagagaatt atgcagtgct gccataacca     7200

tgagtgataa cactgcggcc aacttacttc tgacaacgat cggaggaccg aaggagctaa     7260

ccgctttttt gcacaacatg ggggatcatg taactcgcct tgatcgttgg gaaccggagc     7320

tgaatgaagc cataccaaac gacgagcgtg acaccacgat gcctgtagca atggcaacaa     7380

cgttgcgcaa actattaact ggcgaactac ttactctagc ttcccggcaa caattaatag     7440

actggatgga ggcggataaa gttgcaggac cacttctgcg ctcggccctt ccggctggct     7500

ggtttattgc tgataaatct ggagccggtg agcgtgggtc tcgcggtatc attgcagcac     7560

tggggccaga tggtaagccc tcccgtatcg tagttatcta cacgacgggg agtcaggcaa     7620

ctatggatga acgaaataga cagatcgctg agataggtgc ctcactgatt aagcattggt     7680

aactgtcaga ccaagtttac tcatatatac tttagattga tttaaaactt catttttaat     7740

ttaaaaggat ctaggtgaag atcctttttg ataatctcat gaccaaaatc ccttaacgtg     7800

agttttcgtt ccactgagcg tcagaccccg tagaaaagat caaaggatct tcttgagatc     7860

ctttttttct gcgcgtaatc tgctgcttgc aaacaaaaaa accaccgcta ccagcggtgg     7920

tttgtttgcc ggatcaagag ctaccaactc tttttccgaa ggtaactggc ttcagcagag     7980

cgcagatacc aaatactgtt cttctagtgt agccgtagtt aggccaccac ttcaagaact     8040

ctgtagcacc gcctacatac ctcgctctgc taatcctgtt accagtggct gctgccagtg     8100

gcgataagtc gtgtcttacc gggttggact caagacgata gttaccggat aaggcgcagc     8160

ggtcgggctg aacggggggt tcgtgcacac agcccagctt ggagcgaacg acctacaccg     8220

aactgagata cctacagcgt gagctatgag aaagcgccac gcttcccgaa gagagaaagg     8280

cggacaggta tccggtaagc ggcagggtcg gaacaggaga gcgcacgagg gagcttccag     8340

ggggaaacgc ctggtatctt tatagtcctg tcgggtttcg ccacctctga cttgagcgtc     8400

gatttttgtg atgctcgtca ggggggcgga gcctatggaa aaacgccagc aacgcggcct     8460

ttttacggtt cctggccttt tgctggcctt ttgctcacat gttctttcct gcgttatccc     8520

ctgattctgt ggataaccgt attaccgcct ttgagtgagc tgataccgct cgccgcagcc     8580

gaacgaccga gcgcagcgag tcagtgagcg aggaagcgga agagcgccca atacgcaaac     8640

cgcctctccc cgcgcgttgg ccgattcatt aatgcagctg gcacgacagg tttcccgact     8700

ggaaagcggg cagtgagcgc aacgcaatta atgtgagtta gctcactcat taggcacccc     8760

aggctttaca ctttatgctt ccggctcgta tgttgtgtgg aattgtgagc ggataacaat     8820

ttcacacagg aaacagctat gaccatgatt acgccaagcg cgcaattaac cctcactaaa     8880

gggaacaaaa gctggagctg caagctt                                         8907


<210>  620
<211>  8457
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Synthetic nucleotide

<400>  620
aatgtagtct tatgcaatac tcttgtagtc ttgcaacatg gtaacgatga gttagcaaca       60

tgccttacaa ggagagaaaa agcaccgtgc atgccgattg gtggaagtaa ggtggtacga      120

tcgtgcctta ttaggaaggc aacagacggg tctgacatgg attggacgaa ccactgaatt      180

gccgcattgc agagatattg tatttaagtg cctagctcga tacataaacg ggtctctctg      240

gttagaccag atctgagcct gggagctctc tggctaacta gggaacccac tgcttaagcc      300

tcaataaagc ttgccttgag tgcttcaagt agtgtgtgcc cgtctgttgt gtgactctgg      360

taactagaga tccctcagac ccttttagtc agtgtggaaa atctctagca gtggcgcccg      420

aacagggact tgaaagcgaa agggaaacca gaggagctct ctcgacgcag gactcggctt      480

gctgaagcgc gcacggcaag aggcgagggg cggcgactgg tgagtacgcc aaaaattttg      540

actagcggag gctagaagga gagagatggg tgcgagagcg tcagtattaa gcgggggaga      600

attagatcgc gatgggaaaa aattcggtta aggccagggg gaaagaaaaa atataaatta      660

aaacatatag tatgggcaag cagggagcta gaacgattcg cagttaatcc tggcctgtta      720

gaaacatcag aaggctgtag acaaatactg ggacagctac aaccatccct tcagacagga      780

tcagaagaac ttagatcatt atataataca gtagcaaccc tctattgtgt gcatcaaagg      840

atagagataa aagacaccaa ggaagcttta gacaagatag aggaagagca aaacaaaagt      900

aagaccaccg cacagcaagc ggccgctgat cttcagacct ggaggaggag atatgaggga      960

caattggaga agtgaattat ataaatataa agtagtaaaa attgaaccat taggagtagc     1020

acccaccaag gcaaagagaa gagtggtgca gagagaaaaa agagcagtgg gaataggagc     1080

tttgttcctt gggttcttgg gagcagcagg aagcactatg ggcgcagcgt caatgacgct     1140

gacggtacag gccagacaat tattgtctgg tatagtgcag cagcagaaca atttgctgag     1200

ggctattgag gcgcaacagc atctgttgca actcacagtc tggggcatca agcagctcca     1260

ggcaagaatc ctggctgtgg aaagatacct aaaggatcaa cagctcctgg ggatttgggg     1320

ttgctctgga aaactcattt gcaccactgc tgtgccttgg aatgctagtt ggagtaataa     1380

atctctggaa cagatttgga atcacacgac ctggatggag tgggacagag aaattaacaa     1440

ttacacaagc ttaatacact ccttaattga agaatcgcaa aaccagcaag aaaagaatga     1500

acaagaatta ttggaattag ataaatgggc aagtttgtgg aattggttta acataacaaa     1560

ttggctgtgg tatataaaat tattcataat gatagtagga ggcttggtag gtttaagaat     1620

agtttttgct gtactttcta tagtgaatag agttaggcag ggatattcac cattatcgtt     1680

tcagacccac ctcccaaccc cgaggggacc cgacaggccc gaaggaatag aagaagaagg     1740

tggagagaga gacagagaca gatccattcg attagtgaac ggatctcgac ggtatcgcta     1800

gcttttaaaa gaaaaggggg gattgggggg tacagtgcag gggaaagaat agtagacata     1860

atagcaacag acatacaaac taaagaatta caaaaacaaa ttacaaaaat tcaaaatttt     1920

actagtgatt atcggatcaa ctttgtatag aaaagttggg ctccggtgcc cgtcagtggg     1980

cagagcgcac atcgcccaca gtccccgaga agttgggggg aggggtcggc aattgaaccg     2040

gtgcctagag aaggtggcgc ggggtaaact gggaaagtga tgtcgtgtac tggctccgcc     2100

tttttcccga gggtggggga gaaccgtata taagtgcagt agtcgccgtg aacgttcttt     2160

ttcgcaacgg gtttgccgcc agaacacagg taagtgccgt gtgtggttcc cgcgggcctg     2220

gcctctttac gggttatggc ccttgcgtgc cttgaattac ttccacctgg ctgcagtacg     2280

tgattcttga tcccgagctt cgggttggaa gtgggtggga gagttcgagg ccttgcgctt     2340

aaggagcccc ttcgcctcgt gcttgagttg aggcctggcc tgggcgctgg ggccgccgcg     2400

tgcgaatctg gtggcacctt cgcgcctgtc tcgctgcttt cgataagtct ctagccattt     2460

aaaatttttg atgacctgct gcgacgcttt ttttctggca agatagtctt gtaaatgcgg     2520

gccaagatct gcacactggt atttcggttt ttggggccgc gggcggcgac ggggcccgtg     2580

cgtcccagcg cacatgttcg gcgaggcggg gcctgcgagc gcggccaccg agaatcggac     2640

gggggtagtc tcaagctggc cggcctgctc tggtgcctgg tctcgcgccg ccgtgtatcg     2700

ccccgccctg ggcggcaagg ctggcccggt cggcaccagt tgcgtgagcg gaaagatggc     2760

cgcttcccgg ccctgctgca gggagctcaa aatggaggac gcggcgctcg ggagagcggg     2820

cgggtgagtc acccacacaa aggaaaaggg cctttccgtc ctcagccgtc gcttcatgtg     2880

actccacgga gtaccgggcg ccgtccaggc acctcgatta gttctcgagc ttttggagta     2940

cgtcgtcttt aggttggggg gaggggtttt atgcgatgga gtttccccac actgagtggg     3000

tggagactga agttaggcca gcttggcact tgatgtaatt ctccttggaa tttgcccttt     3060

ttgagtttgg atcttggttc attctcaagc ctcagacagt ggttcaaagt ttttttcttc     3120

catttcaggt gtcgtgacaa gtttgtacaa aaaagcaggc tgccaccatg agctatgtgc     3180

tgacccagcc gccgagcgtg agcgtggcgc cgggccagac cgcgcgcatt acctgcggcg     3240

gcaacaacat tggccgcaaa attgtgcatt ggtatcagca gcgcccgggc caggcgccgg     3300

tgctggtgat ttattatgat accgatcgcc cggcgggcat tccggaacgc tttagcggca     3360

gcaacagcgg caacatggcg accctgacca ttagcaccgt gggcgcgggc gatgaagcgg     3420

attattattg ccaggtgtgg gataccggca gcgatcatgt ggtgtttggc ggcggcacca     3480

aactgaccgt gctgggcggc ggcggcagcg gcggcggcgg cagcggcggc ggcggcagcg     3540

aagtgcagct ggtggaaagc ggcggcggcc tggtgcagcc gggcggcagc ctgcgcctga     3600

gctgcgcggc gagcggcttt acctttagca actatgcgat gagctgggtg cgccaggcgc     3660

cgggcaaagg cctggaatgg gtgagcacca ttagcggcag cggcggcacc acctattatg     3720

cggatagcgt gaaaggccgc tttaccatta gccgcgataa cagcaaaaac accctgtatc     3780

tgcagatgaa cagcctgcgc gtggaagata ccgcggtgta ttattgcgcg aaagattggt     3840

ttcgcagcag cagcccggat gcgtttgata tttggggcca gggcaccacc gtgaccgtga     3900

gcgcgaccac gacgccagcg ccgcgaccac caacaccggc gcccaccatc gcgtcgcagc     3960

ccctgtccct gcgcccagag gcgtgccggc cagcggcggg gggcgcagtg cacacgaggg     4020

ggctggactt cgcctgtgat atctacatct gggcgccctt ggccgggact tgtggggtcc     4080

ttctcctgtc actggttatc accctttact gccaacgaag gaaatataga tcaaacaaag     4140

gagaaagtcc tgtggagcct gcagagcctt gtcgttacag ctgccccagg gaggaggagg     4200

gcagcaccat ccccatccag gaggattacc gaaaaccgga gcctgcctgc tccccctgaa     4260

cccagctttc ttgtacaaag tggtgataat cgaattccga taatcaacct ctggattaca     4320

aaatttgtga aagattgact ggtattctta actatgttgc tccttttacg ctatgtggat     4380

acgctgcttt aatgcctttg tatcatgcta ttgcttcccg tatggctttc attttctcct     4440

ccttgtataa atcctggttg ctgtctcttt atgaggagtt gtggcccgtt gtcaggcaac     4500

gtggcgtggt gtgcactgtg tttgctgacg caacccccac tggttggggc attgccacca     4560

cctgtcagct cctttccggg actttcgctt tccccctccc tattgccacg gcggaactca     4620

tcgccgcctg ccttgcccgc tgctggacag gggctcggct gttgggcact gacaattccg     4680

tggtgttgtc ggggaagctg acgtcctttc catggctgct cgcctgtgtt gccacctgga     4740

ttctgcgcgg gacgtccttc tgctacgtcc cttcggccct caatccagcg gaccttcctt     4800

cccgcggcct gctgccggct ctgcggcctc ttccgcgtct tcgccttcgc cctcagacga     4860

gtcggatctc cctttgggcc gcctccccgc atcgggaatt cccgcggttc gctttaagac     4920

caatgactta caaggcagct gtagatctta gccacttttt aaaagaaaag gggggactgg     4980

aagggctaat tcactcccaa cgaagacaag atctgctttt tgcttgtact gggtctctct     5040

ggttagacca gatctgagcc tgggagctct ctggctaact agggaaccca ctgcttaagc     5100

ctcaataaag cttgccttga gtgcttcaag tagtgtgtgc ccgtctgttg tgtgactctg     5160

gtaactagag atccctcaga cccttttagt cagtgtggaa aatctctagc agtagtagtt     5220

catgtcatct tattattcag tatttataac ttgcaaagaa atgaatatca gagagtgaga     5280

ggaacttgtt tattgcagct tataatggtt acaaataaag caatagcatc acaaatttca     5340

caaataaagc atttttttca ctgcattcta gttgtggttt gtccaaactc atcaatgtat     5400

cttatcatgt ctggctctag ctatcccgcc cctaactccg cccatcccgc ccctaactcc     5460

gcccagttcc gcccattctc cgccccatgg ctgactaatt ttttttattt atgcagaggc     5520

cgaggccgcc tcggcctctg agctattcca gaagtagtga ggaggctttt ttggaggcct     5580

agggacgtac ccaattcgcc ctatagtgag tcgtattacg cgcgctcact ggccgtcgtt     5640

ttacaacgtc gtgactggga aaaccctggc gttacccaac ttaatcgcct tgcagcacat     5700

ccccctttcg ccagctggcg taatagcgaa gaggcccgca ccgatcgccc ttcccaacag     5760

ttgcgcagcc tgaatggcga atgggacgcg ccctgtagcg gcgcattaag cgcggcgggt     5820

gtggtggtta cgcgcagcgt gaccgctaca cttgccagcg ccctagcgcc cgctcctttc     5880

gctttcttcc cttcctttct cgccacgttc gccggctttc cccgtcaagc tctaaatcgg     5940

gggctccctt tagggttccg atttagtgct ttacggcacc tcgaccccaa aaaacttgat     6000

tagggtgatg gttcacgtag tgggccatcg ccctgataga cggtttttcg ccctttgacg     6060

ttggagtcca cgttctttaa tagtggactc ttgttccaaa ctggaacaac actcaaccct     6120

atctcggtct attcttttga tttataaggg attttgccga tttcggccta ttggttaaaa     6180

aatgagctga tttaacaaaa atttaacgcg aattttaaca aaatattaac gcttacaatt     6240

taggtggcac ttttcgggga aatgtgcgcg gaacccctat ttgtttattt ttctaaatac     6300

attcaaatat gtatccgctc atgagacaat aaccctgata aatgcttcaa taatattgaa     6360

aaaggaagag tatgagtatt caacatttcc gtgtcgccct tattcccttt tttgcggcat     6420

tttgccttcc tgtttttgct cacccagaaa cgctggtgaa agtaaaagat gctgaagatc     6480

agttgggtgc acgagtgggt tacatcgaac tggatctcaa cagcggtaag atccttgaga     6540

gttttcgccc cgaagaacgt tttccaatga tgagcacttt taaagttctg ctatgtggcg     6600

cggtattatc ccgtattgac gccgggcaag agcaactcgg tcgccgcata cactattctc     6660

agaatgactt ggttgagtac tcaccagtca cagaaaagca tcttacggat ggcatgacag     6720

taagagaatt atgcagtgct gccataacca tgagtgataa cactgcggcc aacttacttc     6780

tgacaacgat cggaggaccg aaggagctaa ccgctttttt gcacaacatg ggggatcatg     6840

taactcgcct tgatcgttgg gaaccggagc tgaatgaagc cataccaaac gacgagcgtg     6900

acaccacgat gcctgtagca atggcaacaa cgttgcgcaa actattaact ggcgaactac     6960

ttactctagc ttcccggcaa caattaatag actggatgga ggcggataaa gttgcaggac     7020

cacttctgcg ctcggccctt ccggctggct ggtttattgc tgataaatct ggagccggtg     7080

agcgtgggtc tcgcggtatc attgcagcac tggggccaga tggtaagccc tcccgtatcg     7140

tagttatcta cacgacgggg agtcaggcaa ctatggatga acgaaataga cagatcgctg     7200

agataggtgc ctcactgatt aagcattggt aactgtcaga ccaagtttac tcatatatac     7260

tttagattga tttaaaactt catttttaat ttaaaaggat ctaggtgaag atcctttttg     7320

ataatctcat gaccaaaatc ccttaacgtg agttttcgtt ccactgagcg tcagaccccg     7380

tagaaaagat caaaggatct tcttgagatc ctttttttct gcgcgtaatc tgctgcttgc     7440

aaacaaaaaa accaccgcta ccagcggtgg tttgtttgcc ggatcaagag ctaccaactc     7500

tttttccgaa ggtaactggc ttcagcagag cgcagatacc aaatactgtt cttctagtgt     7560

agccgtagtt aggccaccac ttcaagaact ctgtagcacc gcctacatac ctcgctctgc     7620

taatcctgtt accagtggct gctgccagtg gcgataagtc gtgtcttacc gggttggact     7680

caagacgata gttaccggat aaggcgcagc ggtcgggctg aacggggggt tcgtgcacac     7740

agcccagctt ggagcgaacg acctacaccg aactgagata cctacagcgt gagctatgag     7800

aaagcgccac gcttcccgaa gagagaaagg cggacaggta tccggtaagc ggcagggtcg     7860

gaacaggaga gcgcacgagg gagcttccag ggggaaacgc ctggtatctt tatagtcctg     7920

tcgggtttcg ccacctctga cttgagcgtc gatttttgtg atgctcgtca ggggggcgga     7980

gcctatggaa aaacgccagc aacgcggcct ttttacggtt cctggccttt tgctggcctt     8040

ttgctcacat gttctttcct gcgttatccc ctgattctgt ggataaccgt attaccgcct     8100

ttgagtgagc tgataccgct cgccgcagcc gaacgaccga gcgcagcgag tcagtgagcg     8160

aggaagcgga agagcgccca atacgcaaac cgcctctccc cgcgcgttgg ccgattcatt     8220

aatgcagctg gcacgacagg tttcccgact ggaaagcggg cagtgagcgc aacgcaatta     8280

atgtgagtta gctcactcat taggcacccc aggctttaca ctttatgctt ccggctcgta     8340

tgttgtgtgg aattgtgagc ggataacaat ttcacacagg aaacagctat gaccatgatt     8400

acgccaagcg cgcaattaac cctcactaaa gggaacaaaa gctggagctg caagctt        8457


<210>  621
<211>  11439
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Synthetic nucleotide

<400>  621
gtcgacggat cgggagatct cccgatcccc tatggtgcac tctcagtaca atctgctctg       60

atgccgcata gttaagccag tatctgctcc ctgcttgtgt gttggaggtc gctgagtagt      120

gcgcgagcaa aatttaagct acaacaaggc aaggcttgac cgacaattgc atgaagaatc      180

tgcttagggt taggcgtttt gcgctgcttc gcgatgtacg ggccagatat acgcgttgac      240

attgattatt gactagttat taatagtaat caattacggg gtcattagtt catagcccat      300

atatggagtt ccgcgttaca taacttacgg taaatggccc gcctggctga ccgcccaacg      360

acccccgccc attgacgtca ataatgacgt atgttcccat agtaacgcca atagggactt      420

tccattgacg tcaatgggtg gagtatttac ggtaaactgc ccacttggca gtacatcaag      480

tgtatcatat gccaagtacg ccccctattg acgtcaatga cggtaaatgg cccgcctggc      540

attatgccca gtacatgacc ttatgggact ttcctacttg gcagtacatc tacgtattag      600

tcatcgctat taccatggtg atgcggtttt ggcagtacat caatgggcgt ggatagcggt      660

ttgactcacg gggatttcca agtctccacc ccattgacgt caatgggagt ttgttttggc      720

accaaaatca acgggacttt ccaaaatgtc gtaacaactc cgccccattg acgcaaatgg      780

gcggtaggcg tgtacggtgg gaggtctata taagcagcgc gttttgcctg tactgggtct      840

ctctggttag accagatctg agcctgggag ctctctggct aactagggaa cccactgctt      900

aagcctcaat aaagcttgcc ttgagtgctt caagtagtgt gtgcccgtct gttgtgtgac      960

tctggtaact agagatccct cagacccttt tagtcagtgt ggaaaatctc tagcagtggc     1020

gcccgaacag ggacttgaaa gcgaaaggga aaccagagga gctctctcga cgcaggactc     1080

ggcttgctga agcgcgcacg gcaagaggcg aggggcggcg actggtgagt acgccaaaaa     1140

ttttgactag cggaggctag aaggagagag atgggtgcga gagcgtcagt attaagcggg     1200

ggagaattag atcgcgatgg gaaaaaattc ggttaaggcc agggggaaag aaaaaatata     1260

aattaaaaca tatagtatgg gcaagcaggg agctagaacg attcgcagtt aatcctggcc     1320

tgttagaaac atcagaaggc tgtagacaaa tactgggaca gctacaacca tcccttcaga     1380

caggatcaga agaacttaga tcattatata atacagtagc aaccctctat tgtgtgcatc     1440

aaaggataga gataaaagac accaaggaag ctttagacaa gatagaggaa gagcaaaaca     1500

aaagtaagac caccgcacag caagcggccg ctgatcttca gacctggagg aggagatatg     1560

agggacaatt ggagaagtga attatataaa tataaagtag taaaaattga accattagga     1620

gtagcaccca ccaaggcaaa gagaagagtg gtgcagagag aaaaaagagc agtgggaata     1680

ggagctttgt tccttgggtt cttgggagca gcaggaagca ctatgggcgc agcgtcaatg     1740

acgctgacgg tacaggccag acaattattg tctggtatag tgcagcagca gaacaatttg     1800

ctgagggcta ttgaggcgca acagcatctg ttgcaactca cagtctgggg catcaagcag     1860

ctccaggcaa gaatcctggc tgtggaaaga tacctaaagg atcaacagct cctggggatt     1920

tggggttgct ctggaaaact catttgcacc actgctgtgc cttggaatgc tagttggagt     1980

aataaatctc tggaacagat ttggaatcac acgacctgga tggagtggga cagagaaatt     2040

aacaattaca caagcttaat acactcctta attgaagaat cgcaaaacca gcaagaaaag     2100

aatgaacaag aattattgga attagataaa tgggcaagtt tgtggaattg gtttaacata     2160

acaaattggc tgtggtatat aaaattattc ataatgatag taggaggctt ggtaggttta     2220

agaatagttt ttgctgtact ttctatagtg aatagagtta ggcagggata ttcaccatta     2280

tcgtttcaga cccacctccc aaccccgagg ggacccgaca ggcccgaagg aatagaagaa     2340

gaaggtggag agagagacag agacagatcc attcgattag tgaacggatc ggcactgcgt     2400

gcgccaattc tgcagacaaa tggcagtatt catccacaat tttaaaagaa aaggggggat     2460

tggggggtac agtgcagggg aaagaatagt agacataata gcaacagaca tacaaactaa     2520

agaattacaa aaacaaatta caaaaattca aaattttcgg gtttattaca gggacagcag     2580

agatccagtt tggttaatta gctagctagg tcttgaaagg agtgggaatt ggctccggtg     2640

cccgtcagtg ggcagagcgc acatcgccca cagtccccga gaagttgggg ggaggggtcg     2700

gcaattgatc cggtgcctag agaaggtggc gcggggtaaa ctgggaaagt gatgtcgtgt     2760

actggctccg cctttttccc gagggtgggg gagaaccgta tataagtgca gtagtcgccg     2820

tgaacgttct ttttcgcaac gggtttgccg ccagaacaca ggaccggttc tagagcgctt     2880

taattaagcc accatggccc tacctgtgac cgctctgctg ctgcctctgg ccctgctgct     2940

gcacgccgct agaccaagct acgtgctgac gcagcctcct tctgtgtctg tggcacctgg     3000

tcagaccgcc cggataacat gcggcggcaa caacatcggc cggaagatcg tgcactggta     3060

tcagcagcgg cctgggcagg ctcctgtgct ggttatctac tacgacaccg acagacctgc     3120

cggcatccct gagcggttta gcggcagcaa cagcggcaac atggctacac tgacaatcag     3180

caccgttggc gctggcgacg aagccgacta ctactgccaa gtgtgggaca caggctctga     3240

ccacgttgtg ttcggcggcg gcaccaagct gaccgtgctg ggcggcggtg gctctggcgg     3300

cggcggatcc ggcggaggcg gcagcggcgg cggcggctcg gaagtgcagc tggtggaaag     3360

cggggggggc ctcgttcagc caggaggcag cctgagactg tcttgcgccg cttctggctt     3420

taccttttcc aactacgcca tgagctgggt gaggcaggcc cccggcaaag gccttgagtg     3480

ggtgagcacc atctccggct ctggaggcac cacctactac gccgactccg tgaaaggcag     3540

attcaccatc agcagagata atagcaagaa caccctgtac ctgcagatga actccctgag     3600

agtggaagat accgccgtgt actactgtgc caaggactgg ttccggagca gcagccctga     3660

tgccttcgac atctggggcc agggcacaac cgtgaccgtg tctgccatcg aggtgatgta     3720

ccctccaccc tacctggaca acgagaagag caacggcaca atcatccacg tgaaaggaaa     3780

acatctgtgc cccagtcctc tgttccccgg ccctagcaag cccttctggg tgctggtcgt     3840

ggtgggaggc gtgctggctt gttacagcct gctggtgaca gttgccttca ttatcttctg     3900

ggtgaactgc agaaatacag gcccttggct gaaaaaggtg ctgaagtgca acacacctga     3960

cccctccaaa ttcttcagcc agctgtccag cgagcacggc ggcgacgtgc agaagtggct     4020

gagctctccc ttcccaagct ccagcttcag cccaggtggc ctggctcctg agatcagccc     4080

tctcgaagtc ctggaacgtg ataaggtgac ccagctgctg ctgcagcagg ataaggtgcc     4140

tgaacccgcc agcctgagca gcaatcacag cctgacgagc tgtttcacca accagggata     4200

cttcttcttt cacctgccgg acgccctgga aatcgaggcc tgtcaggtgt acttcaccta     4260

tgacccctat tctgaagaag atcctgatga gggcgtggca ggagctccaa ccggcagctc     4320

tccccagccc ctgcagcccc tgtctggcga ggacgacgcc tactgcacct tcccttccag     4380

agacgacctg ttactcttct cccccagcct gctgggcggc ccttcgcctc caagcaccgc     4440

ccccggcgga agtggagccg gggaggaaag aatgcccccc tccttgcagg agagagtgcc     4500

tagagattgg gacccccagc ctctgggccc tccaacccct ggcgtgcctg acctcgtgga     4560

cttccaacct cctcctgagc tggtgctgag agaagccggc gaagaggtgc cagacgctgg     4620

accaagagag ggcgttagct ttccctggag cagacctccc ggccagggcg agtttcgggc     4680

cctgaacgcc agactccctc tgaacacaga tgcttacctg agcctgcagg agctgcaggg     4740

ccaagaccct acccaccttg tcggatctgg cgagggtaga ggctctctgc tgacctgtgg     4800

cgacgtggaa gagaaccccg gcccgatggc cctgcctgtg accgccctac tcctgcctct     4860

ggccctgctg ctccatgccg ccagacctaa tttcatgctg actcagcctc acagcgtgag     4920

cgagagcctg ggaaagaccg tgaccatcag ctgcacaggc agcagcggca gcatcgctag     4980

aaagttcgtg caatggtacc agcagagacc tggatcttct cctacaacag tgatctacga     5040

gaacaaccag agacctagcg gcgtatccga ccgcttttcc ggcagcatcg ggtccagcag     5100

caacagcgcc agcctgacga tctccggcct gaagacagag gatgaggccg attactactg     5160

ccagagctac gatagctcta acgtggtgtt cggtggcgga acaaaggtaa cagtgctcgg     5220

cggcggaggc tctggaggcg gaggcagcgg aggtggcggc tctggaggcg gtggcagcca     5280

ggtgcagcta caagagagcg gcggtggcct ggtgaagcct ggcggcagcc tgcgcctgag     5340

ctgcgctgcc agcggcttca cctttagctc ttatagcatg aactgggtcc ggcaggcccc     5400

aggcaagggc ctggaatggg tgagcggaat caacaccgcc ggagataccc actatcccga     5460

gagcgtgaag ggcagattca caattagcag agataatgcc cggaacagcc tgaatctgca     5520

gatgaacagc ctgcgggctg aagacaccgc cgtgtactat tgcgtgcggg aacgggtgga     5580

gagggagtac agtggctacg acgccttcga catctggggc cagggaacca ccgtgaccgt     5640

gtctgccatc gaagtgatgt atcctcctcc ctacttggat aacgaaaaaa gcaacggcac     5700

cattatccac gtaaagggga agcacctgtg tcccagtccc ctgttcccag gcccttctaa     5760

gcctttctgg gtgctggtcg tggtgggcgg ggtgctggcc tgctactccc tactggtgac     5820

cgtggccttt atcatctttt gggtggagcg aactatgcca agaatcccca cactgaaaaa     5880

cctggaggac ctggtgacag agtaccacgg caatttcagc gcctggtccg gcgtgtctaa     5940

gggactggcc gagagccttc aaccagacta cagcgagaga ctgtgcctgg tgtctgagat     6000

cccccctaag ggcggagccc tgggcgaagg acccggcgcc tctccctgca atcagcacag     6060

tccatactgg gcccctccgt gctacaccct gaagcctgaa acctgagaat tcgatatcaa     6120

gcttatcggt aatcaacctc tggattacaa aatttgtgaa agattgactg gtattcttaa     6180

ctatgttgct ccttttacgc tatgtggata cgctgcttta atgcctttgt atcatgctat     6240

tgcttcccgt atggctttca ttttctcctc cttgtataaa tcctggttgc tgtctcttta     6300

tgaggagttg tggcccgttg tcaggcaacg tggcgtggtg tgcactgtgt ttgctgacgc     6360

aacccccact ggttggggca ttgccaccac ctgtcagctc ctttccggga ctttcgcttt     6420

ccccctccct attgccacgg cggaactcat cgccgcctgc cttgcccgct gctggacagg     6480

ggctcggctg ttgggcactg acaattccgt ggtgttgtcg gggaaatcat cgtcctttcc     6540

ttggctgctc gcctgtgttg ccacctggat tctgcgcggg acgtccttct gctacgtccc     6600

ttcggccctc aatccagcgg accttccttc ccgcggcctg ctgccggctc tgcggcctct     6660

tccgcgtctt cgccttcgcc ctcagacgag tcggatctcc ctttgggccg cctccccgca     6720

tcgataccgt cgacctcgag acctagaaaa acatggagca atcacaagta gcaatacagc     6780

agctaccaat gctgattgtg cctggctaga agcacaagag gaggaggagg tgggttttcc     6840

agtcacacct caggtacctt taagaccaat gacttacaag gcagctgtag atcttagcca     6900

ctttttaaaa gaaaaggggg gactggaagg gctaattcac tcccaacgaa gacaagatat     6960

ccttgatctg tggatctacc acacacaagg ctacttccct gattggcaga actacacacc     7020

agggccaggg atcagatatc cactgacctt tggatggtgc tacaagctag taccagttga     7080

gcaagagaag gtagaagaag ccaatgaagg agagaacacc cgcttgttac accctgtgag     7140

cctgcatggg atggatgacc cggagagaga agtattagag tggaggtttg acagccgcct     7200

agcatttcat cacatggccc gagagctgca tccggactgt actgggtctc tctggttaga     7260

ccagatctga gcctgggagc tctctggcta actagggaac ccactgctta agcctcaata     7320

aagcttgcct tgagtgcttc aagtagtgtg tgcccgtctg ttgtgtgact ctggtaacta     7380

gagatccctc agaccctttt agtcagtgtg gaaaatctct agcagggccc gtttaaaccc     7440

gctgatcagc ctcgactgtg ccttctagtt gccagccatc tgttgtttgc ccctcccccg     7500

tgccttcctt gaccctggaa ggtgccactc ccactgtcct ttcctaataa aatgaggaaa     7560

ttgcatcgca ttgtctgagt aggtgtcatt ctattctggg gggtggggtg gggcaggaca     7620

gcaaggggga ggattgggaa gacaatagca ggcatgctgg ggatgcggtg ggctctatgg     7680

cttctgaggc ggaaagaacc agctggggct ctagggggta tccccacgcg ccctgtagcg     7740

gcgcattaag cgcggcgggt gtggtggtta cgcgcagcgt gaccgctaca cttgccagcg     7800

ccctagcgcc cgctcctttc gctttcttcc cttcctttct cgccacgttc gccggctttc     7860

cccgtcaagc tctaaatcgg gggctccctt tagggttccg atttagtgct ttacggcacc     7920

tcgaccccaa aaaacttgat tagggtgatg gttcacgtag tgggccatcg ccctgataga     7980

cggtttttcg ccctttgacg ttggagtcca cgttctttaa tagtggactc ttgttccaaa     8040

ctggaacaac actcaaccct atctcggtct attcttttga tttataaggg attttgccga     8100

tttcggccta ttggttaaaa aatgagctga tttaacaaaa atttaacgcg aattaattct     8160

gtggaatgtg tgtcagttag ggtgtggaaa gtccccaggc tccccagcag gcagaagtat     8220

gcaaagcatg catctcaatt agtcagcaac caggtgtgga aagtccccag gctccccagc     8280

aggcagaagt atgcaaagca tgcatctcaa ttagtcagca accatagtcc cgcccctaac     8340

tccgcccatc ccgcccctaa ctccgcccag ttccgcccat tctccgcccc atggctgact     8400

aatttttttt atttatgcag aggccgaggc cgcctctgcc tctgagctat tccagaagta     8460

gtgaggaggc ttttttggag gcctaggctt ttgcaaaaag ctcccgggag cttgtatatc     8520

cattttcgga tctgatcagc acgtgttgac aattaatcat cggcatagta tatcggcata     8580

gtataatacg acaaggtgag gaactaaacc atggccaagt tgaccagtgc cgttccggtg     8640

ctcaccgcgc gcgacgtcgc cggagcggtc gagttctgga ccgaccggct cgggttctcc     8700

cgggacttcg tggaggacga cttcgccggt gtggtccggg acgacgtgac cctgttcatc     8760

agcgcggtcc aggaccaggt ggtgccggac aacaccctgg cctgggtgtg ggtgcgcggc     8820

ctggacgagc tgtacgccga gtggtcggag gtcgtgtcca cgaacttccg ggacgcctcc     8880

gggccggcca tgaccgagat cggcgagcag ccgtgggggc gggagttcgc cctgcgcgac     8940

ccggccggca actgcgtgca cttcgtggcc gaggagcagg actgacacgt gctacgagat     9000

ttcgattcca ccgccgcctt ctatgaaagg ttgggcttcg gaatcgtttt ccgggacgcc     9060

ggctggatga tcctccagcg cggggatctc atgctggagt tcttcgccca ccccaacttg     9120

tttattgcag cttataatgg ttacaaataa agcaatagca tcacaaattt cacaaataaa     9180

gcattttttt cactgcattc tagttgtggt ttgtccaaac tcatcaatgt atcttatcat     9240

gtctgtatac cgtcgacctc tagctagagc ttggcgtaat catggtcata gctgtttcct     9300

gtgtgaaatt gttatccgct cacaattcca cacaacatac gagccggaag cataaagtgt     9360

aaagcctggg gtgcctaatg agtgagctaa ctcacattaa ttgcgttgcg ctcactgccc     9420

gctttccagt cgggaaacct gtcgtgccag ctgcattaat gaatcggcca acgcgcgggg     9480

agaggcggtt tgcgtattgg gcgctcttcc gcttcctcgc tcactgactc gctgcgctcg     9540

gtcgttcggc tgcggcgagc ggtatcagct cactcaaagg cggtaatacg gttatccaca     9600

gaatcagggg ataacgcagg aaagaacatg tgagcaaaag gccagcaaaa ggccaggaac     9660

cgtaaaaagg ccgcgttgct ggcgtttttc cataggctcc gcccccctga cgagcatcac     9720

aaaaatcgac gctcaagtca gaggtggcga aacccgacag gactataaag ataccaggcg     9780

tttccccctg gaagctccct cgtgcgctct cctgttccga ccctgccgct taccggatac     9840

ctgtccgcct ttctcccttc gggaagcgtg gcgctttctc atagctcacg ctgtaggtat     9900

ctcagttcgg tgtaggtcgt tcgctccaag ctgggctgtg tgcacgaacc ccccgttcag     9960

cccgaccgct gcgccttatc cggtaactat cgtcttgagt ccaacccggt aagacacgac    10020

ttatcgccac tggcagcagc cactggtaac aggattagca gagcgaggta tgtaggcggt    10080

gctacagagt tcttgaagtg gtggcctaac tacggctaca ctagaagaac agtatttggt    10140

atctgcgctc tgctgaagcc agttaccttc ggaaaaagag ttggtagctc ttgatccggc    10200

aaacaaacca ccgctggtag cggtggtttt tttgtttgca agcagcagat tacgcgcaga    10260

aaaaaaggat ctcaagaaga tcctttgatc ttttctacgg ggtctgacgc tcagtggaac    10320

gaaaactcac gttaagggat tttggtcatg agattatcaa aaaggatctt cacctagatc    10380

cttttaaatt aaaaatgaag ttttaaatca atctaaagta tatatgagta aacttggtct    10440

gacagttacc aatgcttaat cagtgaggca cctatctcag cgatctgtct atttcgttca    10500

tccatagttg cctgactccc cgtcgtgtag ataactacga tacgggaggg cttaccatct    10560

ggccccagtg ctgcaatgat accgcgagac ccacgctcac cggctccaga tttatcagca    10620

ataaaccagc cagccggaag ggccgagcgc agaagtggtc ctgcaacttt atccgcctcc    10680

atccagtcta ttaattgttg ccgggaagct agagtaagta gttcgccagt taatagtttg    10740

cgcaacgttg ttgccattgc tacaggcatc gtggtgtcac gctcgtcgtt tggtatggct    10800

tcattcagct ccggttccca acgatcaagg cgagttacat gatcccccat gttgtgcaaa    10860

aaagcggtta gctccttcgg tcctccgatc gttgtcagaa gtaagttggc cgcagtgtta    10920

tcactcatgg ttatggcagc actgcataat tctcttactg tcatgccatc cgtaagatgc    10980

ttttctgtga ctggtgagta ctcaaccaag tcattctgag aatagtgtat gcggcgaccg    11040

agttgctctt gcccggcgtc aatacgggat aataccgcgc cacatagcag aactttaaaa    11100

gtgctcatca ttggaaaacg ttcttcgggg cgaaaactct caaggatctt accgctgttg    11160

agatccagtt cgatgtaacc cactcgtgca cccaactgat cttcagcatc ttttactttc    11220

accagcgttt ctgggtgagc aaaaacagga aggcaaaatg ccgcaaaaaa gggaataagg    11280

gcgacacgga aatgttgaat actcatactc ttcctttttc aatattattg aagcatttat    11340

cagggttatt gtctcatgag cggatacata tttgaatgta tttagaaaaa taaacaaata    11400

ggggttccgc gcacatttcc ccgaaaagtg ccacctgac                           11439


<210>  622
<211>  11565
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Synthetic nucleotide

<400>  622
gtcgacggat cgggagatct cccgatcccc tatggtgcac tctcagtaca atctgctctg       60

atgccgcata gttaagccag tatctgctcc ctgcttgtgt gttggaggtc gctgagtagt      120

gcgcgagcaa aatttaagct acaacaaggc aaggcttgac cgacaattgc atgaagaatc      180

tgcttagggt taggcgtttt gcgctgcttc gcgatgtacg ggccagatat acgcgttgac      240

attgattatt gactagttat taatagtaat caattacggg gtcattagtt catagcccat      300

atatggagtt ccgcgttaca taacttacgg taaatggccc gcctggctga ccgcccaacg      360

acccccgccc attgacgtca ataatgacgt atgttcccat agtaacgcca atagggactt      420

tccattgacg tcaatgggtg gagtatttac ggtaaactgc ccacttggca gtacatcaag      480

tgtatcatat gccaagtacg ccccctattg acgtcaatga cggtaaatgg cccgcctggc      540

attatgccca gtacatgacc ttatgggact ttcctacttg gcagtacatc tacgtattag      600

tcatcgctat taccatggtg atgcggtttt ggcagtacat caatgggcgt ggatagcggt      660

ttgactcacg gggatttcca agtctccacc ccattgacgt caatgggagt ttgttttggc      720

accaaaatca acgggacttt ccaaaatgtc gtaacaactc cgccccattg acgcaaatgg      780

gcggtaggcg tgtacggtgg gaggtctata taagcagcgc gttttgcctg tactgggtct      840

ctctggttag accagatctg agcctgggag ctctctggct aactagggaa cccactgctt      900

aagcctcaat aaagcttgcc ttgagtgctt caagtagtgt gtgcccgtct gttgtgtgac      960

tctggtaact agagatccct cagacccttt tagtcagtgt ggaaaatctc tagcagtggc     1020

gcccgaacag ggacttgaaa gcgaaaggga aaccagagga gctctctcga cgcaggactc     1080

ggcttgctga agcgcgcacg gcaagaggcg aggggcggcg actggtgagt acgccaaaaa     1140

ttttgactag cggaggctag aaggagagag atgggtgcga gagcgtcagt attaagcggg     1200

ggagaattag atcgcgatgg gaaaaaattc ggttaaggcc agggggaaag aaaaaatata     1260

aattaaaaca tatagtatgg gcaagcaggg agctagaacg attcgcagtt aatcctggcc     1320

tgttagaaac atcagaaggc tgtagacaaa tactgggaca gctacaacca tcccttcaga     1380

caggatcaga agaacttaga tcattatata atacagtagc aaccctctat tgtgtgcatc     1440

aaaggataga gataaaagac accaaggaag ctttagacaa gatagaggaa gagcaaaaca     1500

aaagtaagac caccgcacag caagcggccg ctgatcttca gacctggagg aggagatatg     1560

agggacaatt ggagaagtga attatataaa tataaagtag taaaaattga accattagga     1620

gtagcaccca ccaaggcaaa gagaagagtg gtgcagagag aaaaaagagc agtgggaata     1680

ggagctttgt tccttgggtt cttgggagca gcaggaagca ctatgggcgc agcgtcaatg     1740

acgctgacgg tacaggccag acaattattg tctggtatag tgcagcagca gaacaatttg     1800

ctgagggcta ttgaggcgca acagcatctg ttgcaactca cagtctgggg catcaagcag     1860

ctccaggcaa gaatcctggc tgtggaaaga tacctaaagg atcaacagct cctggggatt     1920

tggggttgct ctggaaaact catttgcacc actgctgtgc cttggaatgc tagttggagt     1980

aataaatctc tggaacagat ttggaatcac acgacctgga tggagtggga cagagaaatt     2040

aacaattaca caagcttaat acactcctta attgaagaat cgcaaaacca gcaagaaaag     2100

aatgaacaag aattattgga attagataaa tgggcaagtt tgtggaattg gtttaacata     2160

acaaattggc tgtggtatat aaaattattc ataatgatag taggaggctt ggtaggttta     2220

agaatagttt ttgctgtact ttctatagtg aatagagtta ggcagggata ttcaccatta     2280

tcgtttcaga cccacctccc aaccccgagg ggacccgaca ggcccgaagg aatagaagaa     2340

gaaggtggag agagagacag agacagatcc attcgattag tgaacggatc ggcactgcgt     2400

gcgccaattc tgcagacaaa tggcagtatt catccacaat tttaaaagaa aaggggggat     2460

tggggggtac agtgcagggg aaagaatagt agacataata gcaacagaca tacaaactaa     2520

agaattacaa aaacaaatta caaaaattca aaattttcgg gtttattaca gggacagcag     2580

agatccagtt tggttaatta gctagctagg tcttgaaagg agtgggaatt ggctccggtg     2640

cccgtcagtg ggcagagcgc acatcgccca cagtccccga gaagttgggg ggaggggtcg     2700

gcaattgatc cggtgcctag agaaggtggc gcggggtaaa ctgggaaagt gatgtcgtgt     2760

actggctccg cctttttccc gagggtgggg gagaaccgta tataagtgca gtagtcgccg     2820

tgaacgttct ttttcgcaac gggtttgccg ccagaacaca ggaccggttc tagagcgctt     2880

taattaagcc accatggccc tgcccgtcac cgctctgctg ctgcctctgg ccctgctgct     2940

gcatgccgcc agaccaagct acgtgctgac acagccacct agcgtgtccg tggcccctgg     3000

ccagacagcc agaatcacct gtggcggcaa caatatcgga agaaagatcg tgcactggta     3060

ccagcaaaga cctgggcagg ctcccgtgct ggttatctac tacgacaccg atcggccggc     3120

cggcatccct gaaagattca gtgggagcaa ttccggaaac atggccacac tgacgatctc     3180

cacagttggc gccggcgacg aagccgacta ctactgccag gtgtgggaca ctggcagtga     3240

tcacgtggtg tttggcggtg gaacaaagct gaccgtgctg ggcggcggtg gctccggcgg     3300

cggcgggagc ggcggtgggg gctctggagg aggaggcagt gaggtgcagc tggttgagtc     3360

tggcggcggc ctcgtgcaac ctggcggctc cctgcggctg agctgcgccg ctagcggctt     3420

taccttcagc aattacgcca tgagctgggt cagacaggcc cctggcaagg gtctggaatg     3480

ggtgagtacc atcagcggca gcggtggcac cacatactac gccgacagcg tgaaaggcag     3540

attcaccatc tccagagaca acagtaagaa caccctgtac ctgcagatga actccctgcg     3600

ggtcgaggac accgctgtgt actactgcgc caaggattgg ttcagaagca gttctcctga     3660

cgccttcgac atctggggcc agggcacaac agtgaccgtc tctgctatcg aggtgatgta     3720

tcctcctcca tacctggaca acgagaagag caatggtaca atcatccacg tgaaaggaaa     3780

gcacctctgc cccagccccc tgttccccgg acccagcaag cctttctggg tgctggtggt     3840

ggtcggtggc gtgctggctt gttacagcct gttagtgacc gtggccttta tcatcttttg     3900

ggtttacagg gtggacctgg tgctgttcta ccggcacttg acaagaagag acgagacact     3960

gacagacggc aagacctacg atgccttcgt gagctacctg aaggaatgta gacccgagaa     4020

cggcgaggaa cacaccttcg ccgtggaaat cctgcctcgg gtgctggaaa agcatttcgg     4080

ctataagctg tgtatctttg agcgggatgt ggtgccgggc ggagccgtgg tagacgagat     4140

ccacagcctg atcgagaaga gcagaaggct gatcatcgtg ctgtctaaga gctacatgag     4200

caacgaggtg agatacgagc tggagagcgg cctgcacgag gccctggtgg aaagaaagat     4260

caagatcatc cttatcgagt tcacccccgt gaccgacttc acattcctgc cccagtctct     4320

gaaactgctc aagagccaca gagtgctgaa atggaaggcc gataagagcc tgtcttacaa     4380

cagcagattc tggaagaacc tgctgtatct gatgcctgct aagacagtga agcctggcag     4440

ggatgagccc gaggtgctgc ccgtgctgtc tgagagcggc agcggagagg gccggggcag     4500

cttactgacc tgcggtgacg tggaagaaaa ccctggacct atggccctgc cagtgaccgc     4560

cctgctgctg cccctggccc tgctgctgca cgccgctcga cccaacttca tgctgaccca     4620

gcctcacagc gtgtccgaaa gcttgggcaa gaccgtgact atatcttgca ccgggtcttc     4680

cggcagcatc gccaggaagt ttgtgcagtg gtatcagcag agacctggta gcagcccaac     4740

caccgtgatc tacgagaaca accagcggcc cagcggagtg tccgaccggt tcagcggctc     4800

tatcggctca tccagcaatt ctgccagcct gaccatatct ggcttgaaaa ccgaggacga     4860

agcagattac tactgtcaga gctatgatag cagcaacgtg gttttcggcg gcggcaccaa     4920

ggtgacagtg ctcggaggcg gcggctcagg gggcggagga tcaggcggcg gcggcagcgg     4980

cggaggcggc agccaagtgc agctgcagga gagcggaggc ggcctggtga aacctggcgg     5040

gtctctgagg ctgagctgcg ccgcctctgg atttaccttc agcagctaca gcatgaactg     5100

ggtcagacag gcccctggca agggactgga atgggtgtct ggcatcaaca ccgccggcga     5160

cacccactac cccgaatccg tgaagggcag attcactatc tcccgcgata atgccagaaa     5220

ctccctcaac ctgcaaatga acagcctgcg ggccgaggac accgctgtgt actattgcgt     5280

gagagagaga gttgaacggg aatactccgg ctacgacgcc tttgacatct ggggccaggg     5340

aaccacagtg acagtgtctg ccatcgaagt gatgtacccc ccaccttatc tggataacga     5400

gaagagcaac ggcaccatca ttcacgtgaa aggcaaacat ctgtgccctt ctcctctgtt     5460

tcctggccct tctaagccct tctgggtcct ggtggtggtg ggcggcgtgc tagcctgcta     5520

cagcctgctg gtcaccgttg ccttcatcat cttttgggtg agcgccttgc tgtatagaca     5580

ctggatcgag attgtgctgc tgtaccggac ataccagagc aaggaccaga ccctgggcga     5640

caagaaggac ttcgacgcct tcgtgtccta cgccaagtgg agcagcttcc caagcgaggc     5700

caccagctcc ctgagcgaag agcacctggc tctgagcctg ttccccgatg tgctggaaaa     5760

caagtacggc tactcactct gcctgctgga aagagatgtg gcacctggcg gcgtgtacgc     5820

agaggatatc gtgtccatca ttaagcgaag ccggagaggc atcttcatcc tgtcccctaa     5880

ttacgtgaac ggccccagca tcttcgagct gcaggccgct gtcaacctgg ccctggacga     5940

ccagaccctg aagctgatcc tgatcaaatt ctgctacttc caggagcctg agagcctgcc     6000

tcaccttgtc aagaaagccc tgagagtgct gccaaccgtg acatggcggg ggctgaagag     6060

cgttcctcct aacagccggt tttgggccaa aatgcggtac cacatgcccg tgaagaacag     6120

ccagggcttc acctggaacc agctgagaat caccagcaga atcttccagt ggaagggcct     6180

gagccggacc gagacaaccg gccggagcag ccagccaaag gaatggtgat aagaattcga     6240

tatcaagctt atcggtaatc aacctctgga ttacaaaatt tgtgaaagat tgactggtat     6300

tcttaactat gttgctcctt ttacgctatg tggatacgct gctttaatgc ctttgtatca     6360

tgctattgct tcccgtatgg ctttcatttt ctcctccttg tataaatcct ggttgctgtc     6420

tctttatgag gagttgtggc ccgttgtcag gcaacgtggc gtggtgtgca ctgtgtttgc     6480

tgacgcaacc cccactggtt ggggcattgc caccacctgt cagctccttt ccgggacttt     6540

cgctttcccc ctccctattg ccacggcgga actcatcgcc gcctgccttg cccgctgctg     6600

gacaggggct cggctgttgg gcactgacaa ttccgtggtg ttgtcgggga aatcatcgtc     6660

ctttccttgg ctgctcgcct gtgttgccac ctggattctg cgcgggacgt ccttctgcta     6720

cgtcccttcg gccctcaatc cagcggacct tccttcccgc ggcctgctgc cggctctgcg     6780

gcctcttccg cgtcttcgcc ttcgccctca gacgagtcgg atctcccttt gggccgcctc     6840

cccgcatcga taccgtcgac ctcgagacct agaaaaacat ggagcaatca caagtagcaa     6900

tacagcagct accaatgctg attgtgcctg gctagaagca caagaggagg aggaggtggg     6960

ttttccagtc acacctcagg tacctttaag accaatgact tacaaggcag ctgtagatct     7020

tagccacttt ttaaaagaaa aggggggact ggaagggcta attcactccc aacgaagaca     7080

agatatcctt gatctgtgga tctaccacac acaaggctac ttccctgatt ggcagaacta     7140

cacaccaggg ccagggatca gatatccact gacctttgga tggtgctaca agctagtacc     7200

agttgagcaa gagaaggtag aagaagccaa tgaaggagag aacacccgct tgttacaccc     7260

tgtgagcctg catgggatgg atgacccgga gagagaagta ttagagtgga ggtttgacag     7320

ccgcctagca tttcatcaca tggcccgaga gctgcatccg gactgtactg ggtctctctg     7380

gttagaccag atctgagcct gggagctctc tggctaacta gggaacccac tgcttaagcc     7440

tcaataaagc ttgccttgag tgcttcaagt agtgtgtgcc cgtctgttgt gtgactctgg     7500

taactagaga tccctcagac ccttttagtc agtgtggaaa atctctagca gggcccgttt     7560

aaacccgctg atcagcctcg actgtgcctt ctagttgcca gccatctgtt gtttgcccct     7620

cccccgtgcc ttccttgacc ctggaaggtg ccactcccac tgtcctttcc taataaaatg     7680

aggaaattgc atcgcattgt ctgagtaggt gtcattctat tctggggggt ggggtggggc     7740

aggacagcaa gggggaggat tgggaagaca atagcaggca tgctggggat gcggtgggct     7800

ctatggcttc tgaggcggaa agaaccagct ggggctctag ggggtatccc cacgcgccct     7860

gtagcggcgc attaagcgcg gcgggtgtgg tggttacgcg cagcgtgacc gctacacttg     7920

ccagcgccct agcgcccgct cctttcgctt tcttcccttc ctttctcgcc acgttcgccg     7980

gctttccccg tcaagctcta aatcgggggc tccctttagg gttccgattt agtgctttac     8040

ggcacctcga ccccaaaaaa cttgattagg gtgatggttc acgtagtggg ccatcgccct     8100

gatagacggt ttttcgccct ttgacgttgg agtccacgtt ctttaatagt ggactcttgt     8160

tccaaactgg aacaacactc aaccctatct cggtctattc ttttgattta taagggattt     8220

tgccgatttc ggcctattgg ttaaaaaatg agctgattta acaaaaattt aacgcgaatt     8280

aattctgtgg aatgtgtgtc agttagggtg tggaaagtcc ccaggctccc cagcaggcag     8340

aagtatgcaa agcatgcatc tcaattagtc agcaaccagg tgtggaaagt ccccaggctc     8400

cccagcaggc agaagtatgc aaagcatgca tctcaattag tcagcaacca tagtcccgcc     8460

cctaactccg cccatcccgc ccctaactcc gcccagttcc gcccattctc cgccccatgg     8520

ctgactaatt ttttttattt atgcagaggc cgaggccgcc tctgcctctg agctattcca     8580

gaagtagtga ggaggctttt ttggaggcct aggcttttgc aaaaagctcc cgggagcttg     8640

tatatccatt ttcggatctg atcagcacgt gttgacaatt aatcatcggc atagtatatc     8700

ggcatagtat aatacgacaa ggtgaggaac taaaccatgg ccaagttgac cagtgccgtt     8760

ccggtgctca ccgcgcgcga cgtcgccgga gcggtcgagt tctggaccga ccggctcggg     8820

ttctcccggg acttcgtgga ggacgacttc gccggtgtgg tccgggacga cgtgaccctg     8880

ttcatcagcg cggtccagga ccaggtggtg ccggacaaca ccctggcctg ggtgtgggtg     8940

cgcggcctgg acgagctgta cgccgagtgg tcggaggtcg tgtccacgaa cttccgggac     9000

gcctccgggc cggccatgac cgagatcggc gagcagccgt gggggcggga gttcgccctg     9060

cgcgacccgg ccggcaactg cgtgcacttc gtggccgagg agcaggactg acacgtgcta     9120

cgagatttcg attccaccgc cgccttctat gaaaggttgg gcttcggaat cgttttccgg     9180

gacgccggct ggatgatcct ccagcgcggg gatctcatgc tggagttctt cgcccacccc     9240

aacttgttta ttgcagctta taatggttac aaataaagca atagcatcac aaatttcaca     9300

aataaagcat ttttttcact gcattctagt tgtggtttgt ccaaactcat caatgtatct     9360

tatcatgtct gtataccgtc gacctctagc tagagcttgg cgtaatcatg gtcatagctg     9420

tttcctgtgt gaaattgtta tccgctcaca attccacaca acatacgagc cggaagcata     9480

aagtgtaaag cctggggtgc ctaatgagtg agctaactca cattaattgc gttgcgctca     9540

ctgcccgctt tccagtcggg aaacctgtcg tgccagctgc attaatgaat cggccaacgc     9600

gcggggagag gcggtttgcg tattgggcgc tcttccgctt cctcgctcac tgactcgctg     9660

cgctcggtcg ttcggctgcg gcgagcggta tcagctcact caaaggcggt aatacggtta     9720

tccacagaat caggggataa cgcaggaaag aacatgtgag caaaaggcca gcaaaaggcc     9780

aggaaccgta aaaaggccgc gttgctggcg tttttccata ggctccgccc ccctgacgag     9840

catcacaaaa atcgacgctc aagtcagagg tggcgaaacc cgacaggact ataaagatac     9900

caggcgtttc cccctggaag ctccctcgtg cgctctcctg ttccgaccct gccgcttacc     9960

ggatacctgt ccgcctttct cccttcggga agcgtggcgc tttctcatag ctcacgctgt    10020

aggtatctca gttcggtgta ggtcgttcgc tccaagctgg gctgtgtgca cgaacccccc    10080

gttcagcccg accgctgcgc cttatccggt aactatcgtc ttgagtccaa cccggtaaga    10140

cacgacttat cgccactggc agcagccact ggtaacagga ttagcagagc gaggtatgta    10200

ggcggtgcta cagagttctt gaagtggtgg cctaactacg gctacactag aagaacagta    10260

tttggtatct gcgctctgct gaagccagtt accttcggaa aaagagttgg tagctcttga    10320

tccggcaaac aaaccaccgc tggtagcggt ggtttttttg tttgcaagca gcagattacg    10380

cgcagaaaaa aaggatctca agaagatcct ttgatctttt ctacggggtc tgacgctcag    10440

tggaacgaaa actcacgtta agggattttg gtcatgagat tatcaaaaag gatcttcacc    10500

tagatccttt taaattaaaa atgaagtttt aaatcaatct aaagtatata tgagtaaact    10560

tggtctgaca gttaccaatg cttaatcagt gaggcaccta tctcagcgat ctgtctattt    10620

cgttcatcca tagttgcctg actccccgtc gtgtagataa ctacgatacg ggagggctta    10680

ccatctggcc ccagtgctgc aatgataccg cgagacccac gctcaccggc tccagattta    10740

tcagcaataa accagccagc cggaagggcc gagcgcagaa gtggtcctgc aactttatcc    10800

gcctccatcc agtctattaa ttgttgccgg gaagctagag taagtagttc gccagttaat    10860

agtttgcgca acgttgttgc cattgctaca ggcatcgtgg tgtcacgctc gtcgtttggt    10920

atggcttcat tcagctccgg ttcccaacga tcaaggcgag ttacatgatc ccccatgttg    10980

tgcaaaaaag cggttagctc cttcggtcct ccgatcgttg tcagaagtaa gttggccgca    11040

gtgttatcac tcatggttat ggcagcactg cataattctc ttactgtcat gccatccgta    11100

agatgctttt ctgtgactgg tgagtactca accaagtcat tctgagaata gtgtatgcgg    11160

cgaccgagtt gctcttgccc ggcgtcaata cgggataata ccgcgccaca tagcagaact    11220

ttaaaagtgc tcatcattgg aaaacgttct tcggggcgaa aactctcaag gatcttaccg    11280

ctgttgagat ccagttcgat gtaacccact cgtgcaccca actgatcttc agcatctttt    11340

actttcacca gcgtttctgg gtgagcaaaa acaggaaggc aaaatgccgc aaaaaaggga    11400

ataagggcga cacggaaatg ttgaatactc atactcttcc tttttcaata ttattgaagc    11460

atttatcagg gttattgtct catgagcgga tacatatttg aatgtattta gaaaaataaa    11520

caaatagggg ttccgcgcac atttccccga aaagtgccac ctgac                    11565


<210>  623
<211>  11415
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Synthetic nucleotide

<400>  623
gtcgacggat cgggagatct cccgatcccc tatggtgcac tctcagtaca atctgctctg       60

atgccgcata gttaagccag tatctgctcc ctgcttgtgt gttggaggtc gctgagtagt      120

gcgcgagcaa aatttaagct acaacaaggc aaggcttgac cgacaattgc atgaagaatc      180

tgcttagggt taggcgtttt gcgctgcttc gcgatgtacg ggccagatat acgcgttgac      240

attgattatt gactagttat taatagtaat caattacggg gtcattagtt catagcccat      300

atatggagtt ccgcgttaca taacttacgg taaatggccc gcctggctga ccgcccaacg      360

acccccgccc attgacgtca ataatgacgt atgttcccat agtaacgcca atagggactt      420

tccattgacg tcaatgggtg gagtatttac ggtaaactgc ccacttggca gtacatcaag      480

tgtatcatat gccaagtacg ccccctattg acgtcaatga cggtaaatgg cccgcctggc      540

attatgccca gtacatgacc ttatgggact ttcctacttg gcagtacatc tacgtattag      600

tcatcgctat taccatggtg atgcggtttt ggcagtacat caatgggcgt ggatagcggt      660

ttgactcacg gggatttcca agtctccacc ccattgacgt caatgggagt ttgttttggc      720

accaaaatca acgggacttt ccaaaatgtc gtaacaactc cgccccattg acgcaaatgg      780

gcggtaggcg tgtacggtgg gaggtctata taagcagcgc gttttgcctg tactgggtct      840

ctctggttag accagatctg agcctgggag ctctctggct aactagggaa cccactgctt      900

aagcctcaat aaagcttgcc ttgagtgctt caagtagtgt gtgcccgtct gttgtgtgac      960

tctggtaact agagatccct cagacccttt tagtcagtgt ggaaaatctc tagcagtggc     1020

gcccgaacag ggacttgaaa gcgaaaggga aaccagagga gctctctcga cgcaggactc     1080

ggcttgctga agcgcgcacg gcaagaggcg aggggcggcg actggtgagt acgccaaaaa     1140

ttttgactag cggaggctag aaggagagag atgggtgcga gagcgtcagt attaagcggg     1200

ggagaattag atcgcgatgg gaaaaaattc ggttaaggcc agggggaaag aaaaaatata     1260

aattaaaaca tatagtatgg gcaagcaggg agctagaacg attcgcagtt aatcctggcc     1320

tgttagaaac atcagaaggc tgtagacaaa tactgggaca gctacaacca tcccttcaga     1380

caggatcaga agaacttaga tcattatata atacagtagc aaccctctat tgtgtgcatc     1440

aaaggataga gataaaagac accaaggaag ctttagacaa gatagaggaa gagcaaaaca     1500

aaagtaagac caccgcacag caagcggccg ctgatcttca gacctggagg aggagatatg     1560

agggacaatt ggagaagtga attatataaa tataaagtag taaaaattga accattagga     1620

gtagcaccca ccaaggcaaa gagaagagtg gtgcagagag aaaaaagagc agtgggaata     1680

ggagctttgt tccttgggtt cttgggagca gcaggaagca ctatgggcgc agcgtcaatg     1740

acgctgacgg tacaggccag acaattattg tctggtatag tgcagcagca gaacaatttg     1800

ctgagggcta ttgaggcgca acagcatctg ttgcaactca cagtctgggg catcaagcag     1860

ctccaggcaa gaatcctggc tgtggaaaga tacctaaagg atcaacagct cctggggatt     1920

tggggttgct ctggaaaact catttgcacc actgctgtgc cttggaatgc tagttggagt     1980

aataaatctc tggaacagat ttggaatcac acgacctgga tggagtggga cagagaaatt     2040

aacaattaca caagcttaat acactcctta attgaagaat cgcaaaacca gcaagaaaag     2100

aatgaacaag aattattgga attagataaa tgggcaagtt tgtggaattg gtttaacata     2160

acaaattggc tgtggtatat aaaattattc ataatgatag taggaggctt ggtaggttta     2220

agaatagttt ttgctgtact ttctatagtg aatagagtta ggcagggata ttcaccatta     2280

tcgtttcaga cccacctccc aaccccgagg ggacccgaca ggcccgaagg aatagaagaa     2340

gaaggtggag agagagacag agacagatcc attcgattag tgaacggatc ggcactgcgt     2400

gcgccaattc tgcagacaaa tggcagtatt catccacaat tttaaaagaa aaggggggat     2460

tggggggtac agtgcagggg aaagaatagt agacataata gcaacagaca tacaaactaa     2520

agaattacaa aaacaaatta caaaaattca aaattttcgg gtttattaca gggacagcag     2580

agatccagtt tggttaatta gctagctagg tcttgaaagg agtgggaatt ggctccggtg     2640

cccgtcagtg ggcagagcgc acatcgccca cagtccccga gaagttgggg ggaggggtcg     2700

gcaattgatc cggtgcctag agaaggtggc gcggggtaaa ctgggaaagt gatgtcgtgt     2760

actggctccg cctttttccc gagggtgggg gagaaccgta tataagtgca gtagtcgccg     2820

tgaacgttct ttttcgcaac gggtttgccg ccagaacaca ggaccggttc tagagcgctt     2880

taattaagcc accatggccc tgcccgtgac agccctgctg ctgcctctgg ccctgctgct     2940

gcacgccgcc cggcctgaaa tcgtgctgac ccagagcccc gccacactga gcctgagccc     3000

tggcgaacgg gccaccctgt cctgtagagc ctctcagacc atcggcacca gcatccactg     3060

gtatcagcag aagcctggcc aagccccacg gctgctcatc tactatgcga gcgagagcat     3120

cagcggcatc cccgcccggt tcagcggcag cggctccggc acagatttca cactgactat     3180

cagctccctg gaacccgagg attttgccgt gtactactgc cagcagagca atagctggcc     3240

cttcaccttc ggccagggca caaagctgga aatcaagggc ggcggcggca gcggcggcgg     3300

cggtagtggc ggcgggggca gcggcggcgg cggctcccaa gtgcagctgg tccagagcgg     3360

agccgaggtg aagaagcccg gcgcctcagt gaaggtgtct tgcaaagcct ctggctacac     3420

cttcacctct tactggatca actgggtcag acaggctccg ggccagggct tggagtggat     3480

gggaaatatc taccctagcg acagctattc taactacaat caaaagttta aggacagagt     3540

gacaatgacc agagatacca gcacatccac cgtgtacatg gaactgagct cccttagaag     3600

cgaggacacg gccgtgtact actgcgccag aggctcttcc ttcgactact ggggccaggg     3660

cacactggtg accgtgtcta agcctacaac cacccctgcc cctaggcccc ctacccctgc     3720

ccctacaatc gccagccaac ctctgtcgct gcggcctgag gcctgcagac ctgcagctgg     3780

cggcgctgtg cacacacgcg gcctggactt tgcctgtgac atctacatcc cttggctggg     3840

ccacctgctg gttggcctga gcggagcctt cggcttcatc atcctggtgt acctgctgat     3900

caactgcaga aacaccggcc cctggctgaa aaaggtgctg aagtgcaata cccctgaccc     3960

tagcaagttc tttagccagc tgtccagcga gcacggcggc gacgtgcaga aatggctgag     4020

ctctcctttt ccatccagtt ctttcagccc tggcggactg gcccctgaga tttctcctct     4080

ggaagtgctg gagagagaca aggtgacaca gctgctgctg cagcaggaca aggtgcccga     4140

gcccgcctcc ctgagcagca accactccct gaccagctgc ttcaccaacc agggttattt     4200

cttcttccac ctgcctgacg ccctggaaat cgaggcctgc caggtgtact ttacatacga     4260

cccctacagc gaagaggatc cggacgaggg agtggccgga gctcctaccg gcagcagccc     4320

tcagccactg cagcccctta gtggcgagga tgacgcttac tgcaccttcc cttcgagaga     4380

tgacctgttg ctgttcagcc ccagcctcct gggtggccct agccctccaa gcaccgcccc     4440

aggcggctca ggagccggcg aagagcggat gcctccttcc ctgcaggaga gagtgccacg     4500

ggactgggac ccccagcccc tgggccctcc aacccctggc gtgcctgatc tggtcgactt     4560

tcagcctcct ccagagctgg tcctgagaga agccggggaa gaggtgcccg acgccggacc     4620

tagagagggc gtgagctttc cctggagcag accccccgga caaggcgagt tcagagccct     4680

gaatgccaga ctgccgctta acaccgatgc ttacctgagc ctgcaagagc tgcagggcca     4740

ggatcctacc cacctggtgg gatccgggga aggcagaggc tctctgctga cctgtggcga     4800

cgtcgaggaa aaccccggcc ccatggctct gccggtgacc gccctgctgt tacctctcgc     4860

cctgctgctg catgccgcca gacccgagat tgtgttgacc cagagtcctg ccacactgag     4920

cctgagccca ggagagcggg ctacactgtc atgcagagcc agccagacca tcggcaccag     4980

catccactgg taccagcaga agcctggaca ggctcctcgg ctgctgatct actacgccag     5040

cgaaagcatc agcggaatcc ccgctagatt ctcaggcagc ggcagcggca cagacttcac     5100

cctgacaatc agctccctgg agcctgagga cttcgccgtg tactactgcc agcaaagcaa     5160

cagctggcct ttcacattcg gacagggcac caagctggag attaagggcg gaggcggctc     5220

tgggggcggc ggcagcggag gcggcgggtc cggcggaggt ggctctcagg tccagctggt     5280

gcagagcggg gctgaagtga aaaaaccagg cgcctcagtg aaggtaagct gtaaagccag     5340

cggctacacc ttcacttctt actggatcaa ctgggtgcgg caggctcctg gacaaggact     5400

ggaatggatg ggcaacatct acccctctga tagctacagc aactacaacc agaagttcaa     5460

ggaccgggtg accatgacaa gagacacctc cacctccacc gtctacatgg aactgagctc     5520

tctgcggagc gaggataccg ccgtgtacta ctgcgccaga ggttcgagct ttgactattg     5580

gggacagggg accctggtga ccgtgtccaa acctacaacg acccccgcgc caagacctcc     5640

gacacccgcc ccaaccatcg ctagccagcc tctgtctctg agacctgagg cctgtcggcc     5700

cgccgctggc ggcgccgtgc ataccagagg cctggacttc gcctgcgaca tctacgtggt     5760

gatcagcgtg ggcagtatgg gcctgataat ctccctcctt tgtgtgtact tctggctgga     5820

aagaactatg cctcggatcc ctaccctgaa gaacctggag gatctggtga ccgagtacca     5880

cggcaacttc agcgcctggt ccggtgttag caaaggcctc gccgaatctc ttcagcctga     5940

ctactctgaa agactatgcc tggtcagcga aatccctcct aagggcggcg ccctgggaga     6000

gggccctggc gcttctcctt gcaaccagca cagcccttac tgggcccctc cttgttacac     6060

cctgaagcct gagacatgat aagaattcga tatcaagctt atcggtaatc aacctctgga     6120

ttacaaaatt tgtgaaagat tgactggtat tcttaactat gttgctcctt ttacgctatg     6180

tggatacgct gctttaatgc ctttgtatca tgctattgct tcccgtatgg ctttcatttt     6240

ctcctccttg tataaatcct ggttgctgtc tctttatgag gagttgtggc ccgttgtcag     6300

gcaacgtggc gtggtgtgca ctgtgtttgc tgacgcaacc cccactggtt ggggcattgc     6360

caccacctgt cagctccttt ccgggacttt cgctttcccc ctccctattg ccacggcgga     6420

actcatcgcc gcctgccttg cccgctgctg gacaggggct cggctgttgg gcactgacaa     6480

ttccgtggtg ttgtcgggga aatcatcgtc ctttccttgg ctgctcgcct gtgttgccac     6540

ctggattctg cgcgggacgt ccttctgcta cgtcccttcg gccctcaatc cagcggacct     6600

tccttcccgc ggcctgctgc cggctctgcg gcctcttccg cgtcttcgcc ttcgccctca     6660

gacgagtcgg atctcccttt gggccgcctc cccgcatcga taccgtcgac ctcgagacct     6720

agaaaaacat ggagcaatca caagtagcaa tacagcagct accaatgctg attgtgcctg     6780

gctagaagca caagaggagg aggaggtggg ttttccagtc acacctcagg tacctttaag     6840

accaatgact tacaaggcag ctgtagatct tagccacttt ttaaaagaaa aggggggact     6900

ggaagggcta attcactccc aacgaagaca agatatcctt gatctgtgga tctaccacac     6960

acaaggctac ttccctgatt ggcagaacta cacaccaggg ccagggatca gatatccact     7020

gacctttgga tggtgctaca agctagtacc agttgagcaa gagaaggtag aagaagccaa     7080

tgaaggagag aacacccgct tgttacaccc tgtgagcctg catgggatgg atgacccgga     7140

gagagaagta ttagagtgga ggtttgacag ccgcctagca tttcatcaca tggcccgaga     7200

gctgcatccg gactgtactg ggtctctctg gttagaccag atctgagcct gggagctctc     7260

tggctaacta gggaacccac tgcttaagcc tcaataaagc ttgccttgag tgcttcaagt     7320

agtgtgtgcc cgtctgttgt gtgactctgg taactagaga tccctcagac ccttttagtc     7380

agtgtggaaa atctctagca gggcccgttt aaacccgctg atcagcctcg actgtgcctt     7440

ctagttgcca gccatctgtt gtttgcccct cccccgtgcc ttccttgacc ctggaaggtg     7500

ccactcccac tgtcctttcc taataaaatg aggaaattgc atcgcattgt ctgagtaggt     7560

gtcattctat tctggggggt ggggtggggc aggacagcaa gggggaggat tgggaagaca     7620

atagcaggca tgctggggat gcggtgggct ctatggcttc tgaggcggaa agaaccagct     7680

ggggctctag ggggtatccc cacgcgccct gtagcggcgc attaagcgcg gcgggtgtgg     7740

tggttacgcg cagcgtgacc gctacacttg ccagcgccct agcgcccgct cctttcgctt     7800

tcttcccttc ctttctcgcc acgttcgccg gctttccccg tcaagctcta aatcgggggc     7860

tccctttagg gttccgattt agtgctttac ggcacctcga ccccaaaaaa cttgattagg     7920

gtgatggttc acgtagtggg ccatcgccct gatagacggt ttttcgccct ttgacgttgg     7980

agtccacgtt ctttaatagt ggactcttgt tccaaactgg aacaacactc aaccctatct     8040

cggtctattc ttttgattta taagggattt tgccgatttc ggcctattgg ttaaaaaatg     8100

agctgattta acaaaaattt aacgcgaatt aattctgtgg aatgtgtgtc agttagggtg     8160

tggaaagtcc ccaggctccc cagcaggcag aagtatgcaa agcatgcatc tcaattagtc     8220

agcaaccagg tgtggaaagt ccccaggctc cccagcaggc agaagtatgc aaagcatgca     8280

tctcaattag tcagcaacca tagtcccgcc cctaactccg cccatcccgc ccctaactcc     8340

gcccagttcc gcccattctc cgccccatgg ctgactaatt ttttttattt atgcagaggc     8400

cgaggccgcc tctgcctctg agctattcca gaagtagtga ggaggctttt ttggaggcct     8460

aggcttttgc aaaaagctcc cgggagcttg tatatccatt ttcggatctg atcagcacgt     8520

gttgacaatt aatcatcggc atagtatatc ggcatagtat aatacgacaa ggtgaggaac     8580

taaaccatgg ccaagttgac cagtgccgtt ccggtgctca ccgcgcgcga cgtcgccgga     8640

gcggtcgagt tctggaccga ccggctcggg ttctcccggg acttcgtgga ggacgacttc     8700

gccggtgtgg tccgggacga cgtgaccctg ttcatcagcg cggtccagga ccaggtggtg     8760

ccggacaaca ccctggcctg ggtgtgggtg cgcggcctgg acgagctgta cgccgagtgg     8820

tcggaggtcg tgtccacgaa cttccgggac gcctccgggc cggccatgac cgagatcggc     8880

gagcagccgt gggggcggga gttcgccctg cgcgacccgg ccggcaactg cgtgcacttc     8940

gtggccgagg agcaggactg acacgtgcta cgagatttcg attccaccgc cgccttctat     9000

gaaaggttgg gcttcggaat cgttttccgg gacgccggct ggatgatcct ccagcgcggg     9060

gatctcatgc tggagttctt cgcccacccc aacttgttta ttgcagctta taatggttac     9120

aaataaagca atagcatcac aaatttcaca aataaagcat ttttttcact gcattctagt     9180

tgtggtttgt ccaaactcat caatgtatct tatcatgtct gtataccgtc gacctctagc     9240

tagagcttgg cgtaatcatg gtcatagctg tttcctgtgt gaaattgtta tccgctcaca     9300

attccacaca acatacgagc cggaagcata aagtgtaaag cctggggtgc ctaatgagtg     9360

agctaactca cattaattgc gttgcgctca ctgcccgctt tccagtcggg aaacctgtcg     9420

tgccagctgc attaatgaat cggccaacgc gcggggagag gcggtttgcg tattgggcgc     9480

tcttccgctt cctcgctcac tgactcgctg cgctcggtcg ttcggctgcg gcgagcggta     9540

tcagctcact caaaggcggt aatacggtta tccacagaat caggggataa cgcaggaaag     9600

aacatgtgag caaaaggcca gcaaaaggcc aggaaccgta aaaaggccgc gttgctggcg     9660

tttttccata ggctccgccc ccctgacgag catcacaaaa atcgacgctc aagtcagagg     9720

tggcgaaacc cgacaggact ataaagatac caggcgtttc cccctggaag ctccctcgtg     9780

cgctctcctg ttccgaccct gccgcttacc ggatacctgt ccgcctttct cccttcggga     9840

agcgtggcgc tttctcatag ctcacgctgt aggtatctca gttcggtgta ggtcgttcgc     9900

tccaagctgg gctgtgtgca cgaacccccc gttcagcccg accgctgcgc cttatccggt     9960

aactatcgtc ttgagtccaa cccggtaaga cacgacttat cgccactggc agcagccact    10020

ggtaacagga ttagcagagc gaggtatgta ggcggtgcta cagagttctt gaagtggtgg    10080

cctaactacg gctacactag aagaacagta tttggtatct gcgctctgct gaagccagtt    10140

accttcggaa aaagagttgg tagctcttga tccggcaaac aaaccaccgc tggtagcggt    10200

ggtttttttg tttgcaagca gcagattacg cgcagaaaaa aaggatctca agaagatcct    10260

ttgatctttt ctacggggtc tgacgctcag tggaacgaaa actcacgtta agggattttg    10320

gtcatgagat tatcaaaaag gatcttcacc tagatccttt taaattaaaa atgaagtttt    10380

aaatcaatct aaagtatata tgagtaaact tggtctgaca gttaccaatg cttaatcagt    10440

gaggcaccta tctcagcgat ctgtctattt cgttcatcca tagttgcctg actccccgtc    10500

gtgtagataa ctacgatacg ggagggctta ccatctggcc ccagtgctgc aatgataccg    10560

cgagacccac gctcaccggc tccagattta tcagcaataa accagccagc cggaagggcc    10620

gagcgcagaa gtggtcctgc aactttatcc gcctccatcc agtctattaa ttgttgccgg    10680

gaagctagag taagtagttc gccagttaat agtttgcgca acgttgttgc cattgctaca    10740

ggcatcgtgg tgtcacgctc gtcgtttggt atggcttcat tcagctccgg ttcccaacga    10800

tcaaggcgag ttacatgatc ccccatgttg tgcaaaaaag cggttagctc cttcggtcct    10860

ccgatcgttg tcagaagtaa gttggccgca gtgttatcac tcatggttat ggcagcactg    10920

cataattctc ttactgtcat gccatccgta agatgctttt ctgtgactgg tgagtactca    10980

accaagtcat tctgagaata gtgtatgcgg cgaccgagtt gctcttgccc ggcgtcaata    11040

cgggataata ccgcgccaca tagcagaact ttaaaagtgc tcatcattgg aaaacgttct    11100

tcggggcgaa aactctcaag gatcttaccg ctgttgagat ccagttcgat gtaacccact    11160

cgtgcaccca actgatcttc agcatctttt actttcacca gcgtttctgg gtgagcaaaa    11220

acaggaaggc aaaatgccgc aaaaaaggga ataagggcga cacggaaatg ttgaatactc    11280

atactcttcc tttttcaata ttattgaagc atttatcagg gttattgtct catgagcgga    11340

tacatatttg aatgtattta gaaaaataaa caaatagggg ttccgcgcac atttccccga    11400

aaagtgccac ctgac                                                     11415


<210>  624
<211>  11460
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Synthetic nucleotide

<400>  624
gtcgacggat cgggagatct cccgatcccc tatggtgcac tctcagtaca atctgctctg       60

atgccgcata gttaagccag tatctgctcc ctgcttgtgt gttggaggtc gctgagtagt      120

gcgcgagcaa aatttaagct acaacaaggc aaggcttgac cgacaattgc atgaagaatc      180

tgcttagggt taggcgtttt gcgctgcttc gcgatgtacg ggccagatat acgcgttgac      240

attgattatt gactagttat taatagtaat caattacggg gtcattagtt catagcccat      300

atatggagtt ccgcgttaca taacttacgg taaatggccc gcctggctga ccgcccaacg      360

acccccgccc attgacgtca ataatgacgt atgttcccat agtaacgcca atagggactt      420

tccattgacg tcaatgggtg gagtatttac ggtaaactgc ccacttggca gtacatcaag      480

tgtatcatat gccaagtacg ccccctattg acgtcaatga cggtaaatgg cccgcctggc      540

attatgccca gtacatgacc ttatgggact ttcctacttg gcagtacatc tacgtattag      600

tcatcgctat taccatggtg atgcggtttt ggcagtacat caatgggcgt ggatagcggt      660

ttgactcacg gggatttcca agtctccacc ccattgacgt caatgggagt ttgttttggc      720

accaaaatca acgggacttt ccaaaatgtc gtaacaactc cgccccattg acgcaaatgg      780

gcggtaggcg tgtacggtgg gaggtctata taagcagcgc gttttgcctg tactgggtct      840

ctctggttag accagatctg agcctgggag ctctctggct aactagggaa cccactgctt      900

aagcctcaat aaagcttgcc ttgagtgctt caagtagtgt gtgcccgtct gttgtgtgac      960

tctggtaact agagatccct cagacccttt tagtcagtgt ggaaaatctc tagcagtggc     1020

gcccgaacag ggacttgaaa gcgaaaggga aaccagagga gctctctcga cgcaggactc     1080

ggcttgctga agcgcgcacg gcaagaggcg aggggcggcg actggtgagt acgccaaaaa     1140

ttttgactag cggaggctag aaggagagag atgggtgcga gagcgtcagt attaagcggg     1200

ggagaattag atcgcgatgg gaaaaaattc ggttaaggcc agggggaaag aaaaaatata     1260

aattaaaaca tatagtatgg gcaagcaggg agctagaacg attcgcagtt aatcctggcc     1320

tgttagaaac atcagaaggc tgtagacaaa tactgggaca gctacaacca tcccttcaga     1380

caggatcaga agaacttaga tcattatata atacagtagc aaccctctat tgtgtgcatc     1440

aaaggataga gataaaagac accaaggaag ctttagacaa gatagaggaa gagcaaaaca     1500

aaagtaagac caccgcacag caagcggccg ctgatcttca gacctggagg aggagatatg     1560

agggacaatt ggagaagtga attatataaa tataaagtag taaaaattga accattagga     1620

gtagcaccca ccaaggcaaa gagaagagtg gtgcagagag aaaaaagagc agtgggaata     1680

ggagctttgt tccttgggtt cttgggagca gcaggaagca ctatgggcgc agcgtcaatg     1740

acgctgacgg tacaggccag acaattattg tctggtatag tgcagcagca gaacaatttg     1800

ctgagggcta ttgaggcgca acagcatctg ttgcaactca cagtctgggg catcaagcag     1860

ctccaggcaa gaatcctggc tgtggaaaga tacctaaagg atcaacagct cctggggatt     1920

tggggttgct ctggaaaact catttgcacc actgctgtgc cttggaatgc tagttggagt     1980

aataaatctc tggaacagat ttggaatcac acgacctgga tggagtggga cagagaaatt     2040

aacaattaca caagcttaat acactcctta attgaagaat cgcaaaacca gcaagaaaag     2100

aatgaacaag aattattgga attagataaa tgggcaagtt tgtggaattg gtttaacata     2160

acaaattggc tgtggtatat aaaattattc ataatgatag taggaggctt ggtaggttta     2220

agaatagttt ttgctgtact ttctatagtg aatagagtta ggcagggata ttcaccatta     2280

tcgtttcaga cccacctccc aaccccgagg ggacccgaca ggcccgaagg aatagaagaa     2340

gaaggtggag agagagacag agacagatcc attcgattag tgaacggatc ggcactgcgt     2400

gcgccaattc tgcagacaaa tggcagtatt catccacaat tttaaaagaa aaggggggat     2460

tggggggtac agtgcagggg aaagaatagt agacataata gcaacagaca tacaaactaa     2520

agaattacaa aaacaaatta caaaaattca aaattttcgg gtttattaca gggacagcag     2580

agatccagtt tggttaatta gctagctagg tcttgaaagg agtgggaatt ggctccggtg     2640

cccgtcagtg ggcagagcgc acatcgccca cagtccccga gaagttgggg ggaggggtcg     2700

gcaattgatc cggtgcctag agaaggtggc gcggggtaaa ctgggaaagt gatgtcgtgt     2760

actggctccg cctttttccc gagggtgggg gagaaccgta tataagtgca gtagtcgccg     2820

tgaacgttct ttttcgcaac gggtttgccg ccagaacaca ggaccggttc tagagcgctt     2880

taattaagcc accatggccc tgcccgtcac cgccctgtta ctgcctctgg ccctgttgct     2940

gcacgccgcc agacctgaga ttgtgctgac gcagagccct gccaccctgt ctctgtctcc     3000

tggcgagcgg gccacactga gctgccgggc cagccagacc atcggcacat ctattcactg     3060

gtatcaacag aagcccggcc aggcccctag actgcttatc tactacgcca gcgaaagcat     3120

cagcggcatc ccagctcggt ttagcggcag cggttccggc accgacttca cactgacgat     3180

ctcatctttg gagcctgagg acttcgccgt gtactactgc cagcaaagca acagctggcc     3240

tttcaccttc ggccagggca ccaaactgga aatcaagggc ggcgggggat cgggaggcgg     3300

cggaagcggc ggaggcggct ctggcggagg aggctctcag gttcagctgg ttcaatctgg     3360

agccgaagtg aagaagcctg gcgccagtgt gaaggtgagc tgcaaggcca gcggctacac     3420

ctttaccagc tactggatta actgggtccg ccaggcccct ggacaaggcc tggagtggat     3480

gggcaacatc taccctagcg acagctacag caactacaac cagaagttca aggacagagt     3540

gacaatgacc agggacacca gcaccagcac agtctatatg gaactgagct ctctgagatc     3600

cgaggatacc gccgtgtact actgcgctcg gggttctagc ttcgattact ggggacaggg     3660

caccctggtg acagttagca agcccaccac aacccctgcc ccccggcctc cgacccccgc     3720

ccccacaatc gccagccagc ctctctcgct gagacctgag gcttgcagac cagccgccgg     3780

aggagcagtg cacaccagag gcctggactt tgcttgtgac atctactaca gggtcgacct     3840

ggtcctgttc taccggcacc tgaccagaag agatgagaca ctgacagacg gcaagaccta     3900

cgacgccttt gtgagctacc tgaaggaatg ccggcctgag aatggcgagg aacacacatt     3960

cgccgtggag atcctgccta gagtgctgga gaagcacttc ggctacaagc tgtgcatctt     4020

cgagagagac gtggtgccgg gcggagccgt ggtggacgaa atccattctc tgatcgagaa     4080

gtctcggcgc ctgattatcg tgctgagcaa gagctatatg agcaacgagg tgagatacga     4140

gctggaaagc ggcctgcacg aggccctggt ggaaagaaag atcaaaatca tcctgatcga     4200

gttcacccct gtgacagact tcaccttcct gccacagagc ctgaagctgc tgaagagcca     4260

cagagtgctg aaatggaaag cagataagtc cctcagctac aactcacggt tctggaagaa     4320

cctgctgtac ctgatgcccg ccaaaaccgt gaagcctggc agggacgagc ctgaggtgct     4380

cccagtgcta agcgaaagcg gcagcggaga aggcagaggc agcctgctga cctgcgggga     4440

tgtggaagaa aatcctggac ctatggccct gccagtgacc gccctgctgc tgcctctggc     4500

cttactgctg catgccgcta gacctgagat tgtgctgacc cagtcccccg ctacgttgtc     4560

tctgagcccc ggcgaaagag ccacactgag ctgccgggcc agtcagacca tcggtaccag     4620

catccactgg taccagcaga agcctggcca ggccccaaga ctgctgatct attacgcctc     4680

cgagtccatc agcggaatcc ctgccagatt cagcggcagc ggatctggaa cagatttcac     4740

actgaccatc agcagcctgg aacccgagga cttcgccgtg tactactgcc agcagagcaa     4800

cagctggccc ttcaccttcg gacagggcac caagctggaa atcaagggcg gcggcgggag     4860

cggcgggggc ggcagcggcg gcggcggcag cggcggtggc ggcagccagg tgcagctggt     4920

gcagtctggt gctgaggtga aaaagcctgg cgccagcgtg aaggtgtctt gtaaagcctc     4980

ggggtacacc ttcaccagct attggatcaa ctgggtgcgg caggcgcccg gccagggcct     5040

ggagtggatg ggcaacatct accccagcga cagttacagc aattacaatc agaaattcaa     5100

ggacagagtg accatgacac gggatacatc cacctctact gtgtacatgg aactctcctc     5160

tctgcggagc gaagacaccg ccgtgtacta ctgtgccaga ggcagttctt tcgactactg     5220

gggccagggc actctggtga ccgtcagcaa acccaccaca actcctgcac cacgtccccc     5280

gacacctgct cccaccattg cctctcagcc cctgagcctg cggcctgagg cctgcagacc     5340

cgccgctggc ggcgccgttc acactagagg cctcgacttt gcctgtgata tctacggcgt     5400

gttactgtac atcctgctgg gcaccatcgg aaccctggtg gccgtgctgg ccgccagcgc     5460

cctcctgtac agacactgga tcgagatcgt gctgctgtat agaacatacc agtccaagga     5520

tcagacgttg ggcgacaaga aggatttcga cgcttttgtg tcttacgcca agtggtcgag     5580

ctttcccagc gaggccacct catctctgag cgaagagcac ctggcactgt ctctgttccc     5640

tgacgtgctg gagaacaagt acggctacag tctgtgtctg ctggaacggg acgtggcccc     5700

tggcggagtg tatgctgaag atatcgtgag catcatcaaa agaagccggc gcggcatctt     5760

tatcctgagc cccaactacg tgaacggccc tagcatcttc gagctgcagg ctgccgtcaa     5820

cctggccctg gatgaccaga cccttaagct gatcctgatc aagttctgct acttccagga     5880

gcctgaatcc ctgccccacc tggtgaagaa ggccctgcgc gtgctgccta ccgtgacctg     5940

gcggggcctg aagagcgtgc ctcctaacag cagattctgg gccaagatga gataccacat     6000

gcctgtcaaa aacagccaag gatttacttg gaaccaattg agaatcactt cacggatctt     6060

ccaatggaag ggcctctcta gaaccgagac aaccggccgg agctcccaac ctaaggaatg     6120

gtgataagaa ttcgatatca agcttatcgg taatcaacct ctggattaca aaatttgtga     6180

aagattgact ggtattctta actatgttgc tccttttacg ctatgtggat acgctgcttt     6240

aatgcctttg tatcatgcta ttgcttcccg tatggctttc attttctcct ccttgtataa     6300

atcctggttg ctgtctcttt atgaggagtt gtggcccgtt gtcaggcaac gtggcgtggt     6360

gtgcactgtg tttgctgacg caacccccac tggttggggc attgccacca cctgtcagct     6420

cctttccggg actttcgctt tccccctccc tattgccacg gcggaactca tcgccgcctg     6480

ccttgcccgc tgctggacag gggctcggct gttgggcact gacaattccg tggtgttgtc     6540

ggggaaatca tcgtcctttc cttggctgct cgcctgtgtt gccacctgga ttctgcgcgg     6600

gacgtccttc tgctacgtcc cttcggccct caatccagcg gaccttcctt cccgcggcct     6660

gctgccggct ctgcggcctc ttccgcgtct tcgccttcgc cctcagacga gtcggatctc     6720

cctttgggcc gcctccccgc atcgataccg tcgacctcga gacctagaaa aacatggagc     6780

aatcacaagt agcaatacag cagctaccaa tgctgattgt gcctggctag aagcacaaga     6840

ggaggaggag gtgggttttc cagtcacacc tcaggtacct ttaagaccaa tgacttacaa     6900

ggcagctgta gatcttagcc actttttaaa agaaaagggg ggactggaag ggctaattca     6960

ctcccaacga agacaagata tccttgatct gtggatctac cacacacaag gctacttccc     7020

tgattggcag aactacacac cagggccagg gatcagatat ccactgacct ttggatggtg     7080

ctacaagcta gtaccagttg agcaagagaa ggtagaagaa gccaatgaag gagagaacac     7140

ccgcttgtta caccctgtga gcctgcatgg gatggatgac ccggagagag aagtattaga     7200

gtggaggttt gacagccgcc tagcatttca tcacatggcc cgagagctgc atccggactg     7260

tactgggtct ctctggttag accagatctg agcctgggag ctctctggct aactagggaa     7320

cccactgctt aagcctcaat aaagcttgcc ttgagtgctt caagtagtgt gtgcccgtct     7380

gttgtgtgac tctggtaact agagatccct cagacccttt tagtcagtgt ggaaaatctc     7440

tagcagggcc cgtttaaacc cgctgatcag cctcgactgt gccttctagt tgccagccat     7500

ctgttgtttg cccctccccc gtgccttcct tgaccctgga aggtgccact cccactgtcc     7560

tttcctaata aaatgaggaa attgcatcgc attgtctgag taggtgtcat tctattctgg     7620

ggggtggggt ggggcaggac agcaaggggg aggattggga agacaatagc aggcatgctg     7680

gggatgcggt gggctctatg gcttctgagg cggaaagaac cagctggggc tctagggggt     7740

atccccacgc gccctgtagc ggcgcattaa gcgcggcggg tgtggtggtt acgcgcagcg     7800

tgaccgctac acttgccagc gccctagcgc ccgctccttt cgctttcttc ccttcctttc     7860

tcgccacgtt cgccggcttt ccccgtcaag ctctaaatcg ggggctccct ttagggttcc     7920

gatttagtgc tttacggcac ctcgacccca aaaaacttga ttagggtgat ggttcacgta     7980

gtgggccatc gccctgatag acggtttttc gccctttgac gttggagtcc acgttcttta     8040

atagtggact cttgttccaa actggaacaa cactcaaccc tatctcggtc tattcttttg     8100

atttataagg gattttgccg atttcggcct attggttaaa aaatgagctg atttaacaaa     8160

aatttaacgc gaattaattc tgtggaatgt gtgtcagtta gggtgtggaa agtccccagg     8220

ctccccagca ggcagaagta tgcaaagcat gcatctcaat tagtcagcaa ccaggtgtgg     8280

aaagtcccca ggctccccag caggcagaag tatgcaaagc atgcatctca attagtcagc     8340

aaccatagtc ccgcccctaa ctccgcccat cccgccccta actccgccca gttccgccca     8400

ttctccgccc catggctgac taattttttt tatttatgca gaggccgagg ccgcctctgc     8460

ctctgagcta ttccagaagt agtgaggagg cttttttgga ggcctaggct tttgcaaaaa     8520

gctcccggga gcttgtatat ccattttcgg atctgatcag cacgtgttga caattaatca     8580

tcggcatagt atatcggcat agtataatac gacaaggtga ggaactaaac catggccaag     8640

ttgaccagtg ccgttccggt gctcaccgcg cgcgacgtcg ccggagcggt cgagttctgg     8700

accgaccggc tcgggttctc ccgggacttc gtggaggacg acttcgccgg tgtggtccgg     8760

gacgacgtga ccctgttcat cagcgcggtc caggaccagg tggtgccgga caacaccctg     8820

gcctgggtgt gggtgcgcgg cctggacgag ctgtacgccg agtggtcgga ggtcgtgtcc     8880

acgaacttcc gggacgcctc cgggccggcc atgaccgaga tcggcgagca gccgtggggg     8940

cgggagttcg ccctgcgcga cccggccggc aactgcgtgc acttcgtggc cgaggagcag     9000

gactgacacg tgctacgaga tttcgattcc accgccgcct tctatgaaag gttgggcttc     9060

ggaatcgttt tccgggacgc cggctggatg atcctccagc gcggggatct catgctggag     9120

ttcttcgccc accccaactt gtttattgca gcttataatg gttacaaata aagcaatagc     9180

atcacaaatt tcacaaataa agcatttttt tcactgcatt ctagttgtgg tttgtccaaa     9240

ctcatcaatg tatcttatca tgtctgtata ccgtcgacct ctagctagag cttggcgtaa     9300

tcatggtcat agctgtttcc tgtgtgaaat tgttatccgc tcacaattcc acacaacata     9360

cgagccggaa gcataaagtg taaagcctgg ggtgcctaat gagtgagcta actcacatta     9420

attgcgttgc gctcactgcc cgctttccag tcgggaaacc tgtcgtgcca gctgcattaa     9480

tgaatcggcc aacgcgcggg gagaggcggt ttgcgtattg ggcgctcttc cgcttcctcg     9540

ctcactgact cgctgcgctc ggtcgttcgg ctgcggcgag cggtatcagc tcactcaaag     9600

gcggtaatac ggttatccac agaatcaggg gataacgcag gaaagaacat gtgagcaaaa     9660

ggccagcaaa aggccaggaa ccgtaaaaag gccgcgttgc tggcgttttt ccataggctc     9720

cgcccccctg acgagcatca caaaaatcga cgctcaagtc agaggtggcg aaacccgaca     9780

ggactataaa gataccaggc gtttccccct ggaagctccc tcgtgcgctc tcctgttccg     9840

accctgccgc ttaccggata cctgtccgcc tttctccctt cgggaagcgt ggcgctttct     9900

catagctcac gctgtaggta tctcagttcg gtgtaggtcg ttcgctccaa gctgggctgt     9960

gtgcacgaac cccccgttca gcccgaccgc tgcgccttat ccggtaacta tcgtcttgag    10020

tccaacccgg taagacacga cttatcgcca ctggcagcag ccactggtaa caggattagc    10080

agagcgaggt atgtaggcgg tgctacagag ttcttgaagt ggtggcctaa ctacggctac    10140

actagaagaa cagtatttgg tatctgcgct ctgctgaagc cagttacctt cggaaaaaga    10200

gttggtagct cttgatccgg caaacaaacc accgctggta gcggtggttt ttttgtttgc    10260

aagcagcaga ttacgcgcag aaaaaaagga tctcaagaag atcctttgat cttttctacg    10320

gggtctgacg ctcagtggaa cgaaaactca cgttaaggga ttttggtcat gagattatca    10380

aaaaggatct tcacctagat ccttttaaat taaaaatgaa gttttaaatc aatctaaagt    10440

atatatgagt aaacttggtc tgacagttac caatgcttaa tcagtgaggc acctatctca    10500

gcgatctgtc tatttcgttc atccatagtt gcctgactcc ccgtcgtgta gataactacg    10560

atacgggagg gcttaccatc tggccccagt gctgcaatga taccgcgaga cccacgctca    10620

ccggctccag atttatcagc aataaaccag ccagccggaa gggccgagcg cagaagtggt    10680

cctgcaactt tatccgcctc catccagtct attaattgtt gccgggaagc tagagtaagt    10740

agttcgccag ttaatagttt gcgcaacgtt gttgccattg ctacaggcat cgtggtgtca    10800

cgctcgtcgt ttggtatggc ttcattcagc tccggttccc aacgatcaag gcgagttaca    10860

tgatccccca tgttgtgcaa aaaagcggtt agctccttcg gtcctccgat cgttgtcaga    10920

agtaagttgg ccgcagtgtt atcactcatg gttatggcag cactgcataa ttctcttact    10980

gtcatgccat ccgtaagatg cttttctgtg actggtgagt actcaaccaa gtcattctga    11040

gaatagtgta tgcggcgacc gagttgctct tgcccggcgt caatacggga taataccgcg    11100

ccacatagca gaactttaaa agtgctcatc attggaaaac gttcttcggg gcgaaaactc    11160

tcaaggatct taccgctgtt gagatccagt tcgatgtaac ccactcgtgc acccaactga    11220

tcttcagcat cttttacttt caccagcgtt tctgggtgag caaaaacagg aaggcaaaat    11280

gccgcaaaaa agggaataag ggcgacacgg aaatgttgaa tactcatact cttccttttt    11340

caatattatt gaagcattta tcagggttat tgtctcatga gcggatacat atttgaatgt    11400

atttagaaaa ataaacaaat aggggttccg cgcacatttc cccgaaaagt gccacctgac    11460


<210>  625
<211>  11457
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Synthetic nucleotide

<400>  625
gtcgacggat cgggagatct cccgatcccc tatggtgcac tctcagtaca atctgctctg       60

atgccgcata gttaagccag tatctgctcc ctgcttgtgt gttggaggtc gctgagtagt      120

gcgcgagcaa aatttaagct acaacaaggc aaggcttgac cgacaattgc atgaagaatc      180

tgcttagggt taggcgtttt gcgctgcttc gcgatgtacg ggccagatat acgcgttgac      240

attgattatt gactagttat taatagtaat caattacggg gtcattagtt catagcccat      300

atatggagtt ccgcgttaca taacttacgg taaatggccc gcctggctga ccgcccaacg      360

acccccgccc attgacgtca ataatgacgt atgttcccat agtaacgcca atagggactt      420

tccattgacg tcaatgggtg gagtatttac ggtaaactgc ccacttggca gtacatcaag      480

tgtatcatat gccaagtacg ccccctattg acgtcaatga cggtaaatgg cccgcctggc      540

attatgccca gtacatgacc ttatgggact ttcctacttg gcagtacatc tacgtattag      600

tcatcgctat taccatggtg atgcggtttt ggcagtacat caatgggcgt ggatagcggt      660

ttgactcacg gggatttcca agtctccacc ccattgacgt caatgggagt ttgttttggc      720

accaaaatca acgggacttt ccaaaatgtc gtaacaactc cgccccattg acgcaaatgg      780

gcggtaggcg tgtacggtgg gaggtctata taagcagcgc gttttgcctg tactgggtct      840

ctctggttag accagatctg agcctgggag ctctctggct aactagggaa cccactgctt      900

aagcctcaat aaagcttgcc ttgagtgctt caagtagtgt gtgcccgtct gttgtgtgac      960

tctggtaact agagatccct cagacccttt tagtcagtgt ggaaaatctc tagcagtggc     1020

gcccgaacag ggacttgaaa gcgaaaggga aaccagagga gctctctcga cgcaggactc     1080

ggcttgctga agcgcgcacg gcaagaggcg aggggcggcg actggtgagt acgccaaaaa     1140

ttttgactag cggaggctag aaggagagag atgggtgcga gagcgtcagt attaagcggg     1200

ggagaattag atcgcgatgg gaaaaaattc ggttaaggcc agggggaaag aaaaaatata     1260

aattaaaaca tatagtatgg gcaagcaggg agctagaacg attcgcagtt aatcctggcc     1320

tgttagaaac atcagaaggc tgtagacaaa tactgggaca gctacaacca tcccttcaga     1380

caggatcaga agaacttaga tcattatata atacagtagc aaccctctat tgtgtgcatc     1440

aaaggataga gataaaagac accaaggaag ctttagacaa gatagaggaa gagcaaaaca     1500

aaagtaagac caccgcacag caagcggccg ctgatcttca gacctggagg aggagatatg     1560

agggacaatt ggagaagtga attatataaa tataaagtag taaaaattga accattagga     1620

gtagcaccca ccaaggcaaa gagaagagtg gtgcagagag aaaaaagagc agtgggaata     1680

ggagctttgt tccttgggtt cttgggagca gcaggaagca ctatgggcgc agcgtcaatg     1740

acgctgacgg tacaggccag acaattattg tctggtatag tgcagcagca gaacaatttg     1800

ctgagggcta ttgaggcgca acagcatctg ttgcaactca cagtctgggg catcaagcag     1860

ctccaggcaa gaatcctggc tgtggaaaga tacctaaagg atcaacagct cctggggatt     1920

tggggttgct ctggaaaact catttgcacc actgctgtgc cttggaatgc tagttggagt     1980

aataaatctc tggaacagat ttggaatcac acgacctgga tggagtggga cagagaaatt     2040

aacaattaca caagcttaat acactcctta attgaagaat cgcaaaacca gcaagaaaag     2100

aatgaacaag aattattgga attagataaa tgggcaagtt tgtggaattg gtttaacata     2160

acaaattggc tgtggtatat aaaattattc ataatgatag taggaggctt ggtaggttta     2220

agaatagttt ttgctgtact ttctatagtg aatagagtta ggcagggata ttcaccatta     2280

tcgtttcaga cccacctccc aaccccgagg ggacccgaca ggcccgaagg aatagaagaa     2340

gaaggtggag agagagacag agacagatcc attcgattag tgaacggatc ggcactgcgt     2400

gcgccaattc tgcagacaaa tggcagtatt catccacaat tttaaaagaa aaggggggat     2460

tggggggtac agtgcagggg aaagaatagt agacataata gcaacagaca tacaaactaa     2520

agaattacaa aaacaaatta caaaaattca aaattttcgg gtttattaca gggacagcag     2580

agatccagtt tggttaatta gctagctagg tcttgaaagg agtgggaatt ggctccggtg     2640

cccgtcagtg ggcagagcgc acatcgccca cagtccccga gaagttgggg ggaggggtcg     2700

gcaattgatc cggtgcctag agaaggtggc gcggggtaaa ctgggaaagt gatgtcgtgt     2760

actggctccg cctttttccc gagggtgggg gagaaccgta tataagtgca gtagtcgccg     2820

tgaacgttct ttttcgcaac gggtttgccg ccagaacaca ggaccggttc tagagcgctt     2880

taattaagcc accatggccc tgccggtcac cgccctgctg ctgcccctgg ccctactgct     2940

gcatgccgct aggcctcaga tccagctcgt gcagagcggt cctgagctga agaaacccgg     3000

cgagacagtg aaaatcagct gcaaggccag cggctacaca ttcaccaact atggcatgaa     3060

ctgggtgaag caggcccctg ggaagggcct gaagtggatg ggctggatca atacaaagac     3120

cggcgaaccc acctacgccg aggagttcaa gggcagattc gcctttagct tggagacaag     3180

tgccagcaca gcctacctgc aaattaacaa cctgaaaaaa gaggacaccg ccacctactt     3240

ttgcggcaga ggcggctatg gcagcagcta ctggtacttc gacgtgtggg gcgccggcac     3300

caccgtcaca gtgagcagcg cctctacaaa gggccctagt ggcggaggcg ggtccggtgg     3360

gggcgggtct ggaggcggcg gcagcggcgg cggcggcagc gacatcgtga tgacccaaag     3420

ccacaagttc atgagcacaa gcgtgggcga ccgggtgagc atcacctgca aggccagcca     3480

ggatgtgtct atcgccgtgg cctggtacca gcaaaagccg ggccagagcc ccaaagtgct     3540

gatctattcc gcttcttata gatacaccgg agttcctgat aggttcaccg gatccggctc     3600

cggaacagac ttcacattca ccatcagcag agttcaagct gaggacctgg ccgtgtacta     3660

ctgccagcag cactacatta cccctctcac cttcggcgcc gggaccaagc tggagctgaa     3720

aagaacagta gccatcgagg tgatgtaccc acctccttac ctggacaatg aaaagagcaa     3780

cggcaccatc atccacgtca agggcaaaca cctgtgtcct tccccactgt tccctggacc     3840

ctctaagcct ttttgggtgc tggtcgtggt gggcggcgtg ctggcctgct acagcctgct     3900

ggtgaccgtg gccttcatca tcttctgggt gaactgcaga aacaccggcc cttggctgaa     3960

gaaggtgctg aagtgtaaca cccctgatcc ttccaagttt ttcagccagc tgagcagcga     4020

gcacggcgga gacgttcaga agtggctgtc tagcccattc cctagcagct ctttcagtcc     4080

tggcgggctg gcccctgaga tctctcctct tgaagtgctg gaaagagata aggtgacaca     4140

gctgctcctg cagcaggaca aggtgccaga acctgccagc ctgagcagca atcactctct     4200

aacatcttgc ttcaccaatc agggctactt cttctttcac ctgcctgacg ccctggagat     4260

cgaggcctgt caggtgtact tcacatacga cccctacagc gaggaagatc ctgacgaggg     4320

agttgccgga gctccaacag gatcttctcc acagcccctg cagcctctga gcggagaaga     4380

tgacgcttat tgtacatttc ccagcagaga cgacctactg ctcttcagtc ctagcctcct     4440

gggcggcccc tctccaccta gcaccgcccc tgggggcagc ggcgccggcg aagaacggat     4500

gccccctagt ctccaggagc gggtgccacg ggactgggat cctcagcctc tgggcccccc     4560

aacccctggt gtgcctgatc tggtcgactt ccagcctcct ccggaactgg tgctgaggga     4620

agccggcgag gaagtgccag acgccggccc cagagagggt gtgagctttc catggtcccg     4680

gccccccggc cagggcgagt tcagagccct gaatgcccgg ctgcctctga acacagatgc     4740

ttacctcagc cttcaagagc tgcagggcca ggaccctacc cacctggtcg gctcaggcga     4800

gggcagaggc agcctgctga catgcggcga cgtggaagaa aaccccggcc ccatggccct     4860

gcctgtgacc gccctcctgc tgcctctggc actgctgctg cacgccgcca gacctcaggt     4920

gcagctgcag cagtctggcc ccgaactggt gcggcccgga acctctgtgc ggatcagctg     4980

caaagcctcc ggctacacct ttaccatcta ctggctgggc tgggtgaagc agagaccagg     5040

tcacggcctg gagtggatag gaaacatctt ccctggcagt gcctacatca actacaacga     5100

gaagttcaag ggcaaggcta ccctgaccgc tgacacctct tccagcaccg cctacatgca     5160

gctgagcagc ctgacaagcg aggacagcgc cgtgtacttc tgcgccagag agggaagcaa     5220

cagcggctac tggggccaag gcacgaccct gaccgtgagc tctggcggcg gtggatctgg     5280

cggcggcggt tccggaggcg gagggtctgg aggtggcggc agcgacatcg tgatgactca     5340

gagcccgtct agcctgagcg tgtctgccgg agagaaggtg accatgacat gcaagtccag     5400

ccaaagcctg ctgaacagcg gcaaccagca gaactacctg gcttggtatc agcagaaacc     5460

cggccagccg ccaaagctgc tcatctacgg cgccagcaca agagagagcg gcgtgcccga     5520

tagattcacc ggctcgggct ctggaaccga cttcactctg accatcaaca gcgtgcaagc     5580

tgaggatctg gccgtgtact actgtcagtc tgaccacatc tacccctata cattcggggg     5640

aggcacaaaa ctggaaatca agatcgaagt gatgtaccct ccaccttacc tggataacga     5700

gaagagcaac gggaccatca tccacgtgaa gggaaagcat ctgtgcccct cgcccctgtt     5760

ccccggcccg agcaagcctt tttgggtgct cgtggtggtg ggcggcgtgc tggcctgcta     5820

ctctctgctg gtgaccgtgg ccttcatcat cttctgggtt gagcggacca tgcctagaat     5880

ccccaccctg aaaaacctgg aggatctggt gaccgagtac cacggcaact tctcggcttg     5940

gtccggcgtg agcaagggcc tggccgaaag cctgcagcct gactacagcg aacggctgtg     6000

cctggtcagc gagattcctc ctaaaggcgg cgccctggga gagggccctg gcgcctcacc     6060

ttgtaaccag cacagccctt actgggcgcc tccttgctac accctgaagc ctgagacatg     6120

ataagaattc gatatcaagc ttatcggtaa tcaacctctg gattacaaaa tttgtgaaag     6180

attgactggt attcttaact atgttgctcc ttttacgcta tgtggatacg ctgctttaat     6240

gcctttgtat catgctattg cttcccgtat ggctttcatt ttctcctcct tgtataaatc     6300

ctggttgctg tctctttatg aggagttgtg gcccgttgtc aggcaacgtg gcgtggtgtg     6360

cactgtgttt gctgacgcaa cccccactgg ttggggcatt gccaccacct gtcagctcct     6420

ttccgggact ttcgctttcc ccctccctat tgccacggcg gaactcatcg ccgcctgcct     6480

tgcccgctgc tggacagggg ctcggctgtt gggcactgac aattccgtgg tgttgtcggg     6540

gaaatcatcg tcctttcctt ggctgctcgc ctgtgttgcc acctggattc tgcgcgggac     6600

gtccttctgc tacgtccctt cggccctcaa tccagcggac cttccttccc gcggcctgct     6660

gccggctctg cggcctcttc cgcgtcttcg ccttcgccct cagacgagtc ggatctccct     6720

ttgggccgcc tccccgcatc gataccgtcg acctcgagac ctagaaaaac atggagcaat     6780

cacaagtagc aatacagcag ctaccaatgc tgattgtgcc tggctagaag cacaagagga     6840

ggaggaggtg ggttttccag tcacacctca ggtaccttta agaccaatga cttacaaggc     6900

agctgtagat cttagccact ttttaaaaga aaagggggga ctggaagggc taattcactc     6960

ccaacgaaga caagatatcc ttgatctgtg gatctaccac acacaaggct acttccctga     7020

ttggcagaac tacacaccag ggccagggat cagatatcca ctgacctttg gatggtgcta     7080

caagctagta ccagttgagc aagagaaggt agaagaagcc aatgaaggag agaacacccg     7140

cttgttacac cctgtgagcc tgcatgggat ggatgacccg gagagagaag tattagagtg     7200

gaggtttgac agccgcctag catttcatca catggcccga gagctgcatc cggactgtac     7260

tgggtctctc tggttagacc agatctgagc ctgggagctc tctggctaac tagggaaccc     7320

actgcttaag cctcaataaa gcttgccttg agtgcttcaa gtagtgtgtg cccgtctgtt     7380

gtgtgactct ggtaactaga gatccctcag acccttttag tcagtgtgga aaatctctag     7440

cagggcccgt ttaaacccgc tgatcagcct cgactgtgcc ttctagttgc cagccatctg     7500

ttgtttgccc ctcccccgtg ccttccttga ccctggaagg tgccactccc actgtccttt     7560

cctaataaaa tgaggaaatt gcatcgcatt gtctgagtag gtgtcattct attctggggg     7620

gtggggtggg gcaggacagc aagggggagg attgggaaga caatagcagg catgctgggg     7680

atgcggtggg ctctatggct tctgaggcgg aaagaaccag ctggggctct agggggtatc     7740

cccacgcgcc ctgtagcggc gcattaagcg cggcgggtgt ggtggttacg cgcagcgtga     7800

ccgctacact tgccagcgcc ctagcgcccg ctcctttcgc tttcttccct tcctttctcg     7860

ccacgttcgc cggctttccc cgtcaagctc taaatcgggg gctcccttta gggttccgat     7920

ttagtgcttt acggcacctc gaccccaaaa aacttgatta gggtgatggt tcacgtagtg     7980

ggccatcgcc ctgatagacg gtttttcgcc ctttgacgtt ggagtccacg ttctttaata     8040

gtggactctt gttccaaact ggaacaacac tcaaccctat ctcggtctat tcttttgatt     8100

tataagggat tttgccgatt tcggcctatt ggttaaaaaa tgagctgatt taacaaaaat     8160

ttaacgcgaa ttaattctgt ggaatgtgtg tcagttaggg tgtggaaagt ccccaggctc     8220

cccagcaggc agaagtatgc aaagcatgca tctcaattag tcagcaacca ggtgtggaaa     8280

gtccccaggc tccccagcag gcagaagtat gcaaagcatg catctcaatt agtcagcaac     8340

catagtcccg cccctaactc cgcccatccc gcccctaact ccgcccagtt ccgcccattc     8400

tccgccccat ggctgactaa ttttttttat ttatgcagag gccgaggccg cctctgcctc     8460

tgagctattc cagaagtagt gaggaggctt ttttggaggc ctaggctttt gcaaaaagct     8520

cccgggagct tgtatatcca ttttcggatc tgatcagcac gtgttgacaa ttaatcatcg     8580

gcatagtata tcggcatagt ataatacgac aaggtgagga actaaaccat ggccaagttg     8640

accagtgccg ttccggtgct caccgcgcgc gacgtcgccg gagcggtcga gttctggacc     8700

gaccggctcg ggttctcccg ggacttcgtg gaggacgact tcgccggtgt ggtccgggac     8760

gacgtgaccc tgttcatcag cgcggtccag gaccaggtgg tgccggacaa caccctggcc     8820

tgggtgtggg tgcgcggcct ggacgagctg tacgccgagt ggtcggaggt cgtgtccacg     8880

aacttccggg acgcctccgg gccggccatg accgagatcg gcgagcagcc gtgggggcgg     8940

gagttcgccc tgcgcgaccc ggccggcaac tgcgtgcact tcgtggccga ggagcaggac     9000

tgacacgtgc tacgagattt cgattccacc gccgccttct atgaaaggtt gggcttcgga     9060

atcgttttcc gggacgccgg ctggatgatc ctccagcgcg gggatctcat gctggagttc     9120

ttcgcccacc ccaacttgtt tattgcagct tataatggtt acaaataaag caatagcatc     9180

acaaatttca caaataaagc atttttttca ctgcattcta gttgtggttt gtccaaactc     9240

atcaatgtat cttatcatgt ctgtataccg tcgacctcta gctagagctt ggcgtaatca     9300

tggtcatagc tgtttcctgt gtgaaattgt tatccgctca caattccaca caacatacga     9360

gccggaagca taaagtgtaa agcctggggt gcctaatgag tgagctaact cacattaatt     9420

gcgttgcgct cactgcccgc tttccagtcg ggaaacctgt cgtgccagct gcattaatga     9480

atcggccaac gcgcggggag aggcggtttg cgtattgggc gctcttccgc ttcctcgctc     9540

actgactcgc tgcgctcggt cgttcggctg cggcgagcgg tatcagctca ctcaaaggcg     9600

gtaatacggt tatccacaga atcaggggat aacgcaggaa agaacatgtg agcaaaaggc     9660

cagcaaaagg ccaggaaccg taaaaaggcc gcgttgctgg cgtttttcca taggctccgc     9720

ccccctgacg agcatcacaa aaatcgacgc tcaagtcaga ggtggcgaaa cccgacagga     9780

ctataaagat accaggcgtt tccccctgga agctccctcg tgcgctctcc tgttccgacc     9840

ctgccgctta ccggatacct gtccgccttt ctcccttcgg gaagcgtggc gctttctcat     9900

agctcacgct gtaggtatct cagttcggtg taggtcgttc gctccaagct gggctgtgtg     9960

cacgaacccc ccgttcagcc cgaccgctgc gccttatccg gtaactatcg tcttgagtcc    10020

aacccggtaa gacacgactt atcgccactg gcagcagcca ctggtaacag gattagcaga    10080

gcgaggtatg taggcggtgc tacagagttc ttgaagtggt ggcctaacta cggctacact    10140

agaagaacag tatttggtat ctgcgctctg ctgaagccag ttaccttcgg aaaaagagtt    10200

ggtagctctt gatccggcaa acaaaccacc gctggtagcg gtggtttttt tgtttgcaag    10260

cagcagatta cgcgcagaaa aaaaggatct caagaagatc ctttgatctt ttctacgggg    10320

tctgacgctc agtggaacga aaactcacgt taagggattt tggtcatgag attatcaaaa    10380

aggatcttca cctagatcct tttaaattaa aaatgaagtt ttaaatcaat ctaaagtata    10440

tatgagtaaa cttggtctga cagttaccaa tgcttaatca gtgaggcacc tatctcagcg    10500

atctgtctat ttcgttcatc catagttgcc tgactccccg tcgtgtagat aactacgata    10560

cgggagggct taccatctgg ccccagtgct gcaatgatac cgcgagaccc acgctcaccg    10620

gctccagatt tatcagcaat aaaccagcca gccggaaggg ccgagcgcag aagtggtcct    10680

gcaactttat ccgcctccat ccagtctatt aattgttgcc gggaagctag agtaagtagt    10740

tcgccagtta atagtttgcg caacgttgtt gccattgcta caggcatcgt ggtgtcacgc    10800

tcgtcgtttg gtatggcttc attcagctcc ggttcccaac gatcaaggcg agttacatga    10860

tcccccatgt tgtgcaaaaa agcggttagc tccttcggtc ctccgatcgt tgtcagaagt    10920

aagttggccg cagtgttatc actcatggtt atggcagcac tgcataattc tcttactgtc    10980

atgccatccg taagatgctt ttctgtgact ggtgagtact caaccaagtc attctgagaa    11040

tagtgtatgc ggcgaccgag ttgctcttgc ccggcgtcaa tacgggataa taccgcgcca    11100

catagcagaa ctttaaaagt gctcatcatt ggaaaacgtt cttcggggcg aaaactctca    11160

aggatcttac cgctgttgag atccagttcg atgtaaccca ctcgtgcacc caactgatct    11220

tcagcatctt ttactttcac cagcgtttct gggtgagcaa aaacaggaag gcaaaatgcc    11280

gcaaaaaagg gaataagggc gacacggaaa tgttgaatac tcatactctt cctttttcaa    11340

tattattgaa gcatttatca gggttattgt ctcatgagcg gatacatatt tgaatgtatt    11400

tagaaaaata aacaaatagg ggttccgcgc acatttcccc gaaaagtgcc acctgac       11457


<210>  626
<211>  11580
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Synthetic nucleotide

<400>  626
gtcgacggat cgggagatct cccgatcccc tatggtgcac tctcagtaca atctgctctg       60

atgccgcata gttaagccag tatctgctcc ctgcttgtgt gttggaggtc gctgagtagt      120

gcgcgagcaa aatttaagct acaacaaggc aaggcttgac cgacaattgc atgaagaatc      180

tgcttagggt taggcgtttt gcgctgcttc gcgatgtacg ggccagatat acgcgttgac      240

attgattatt gactagttat taatagtaat caattacggg gtcattagtt catagcccat      300

atatggagtt ccgcgttaca taacttacgg taaatggccc gcctggctga ccgcccaacg      360

acccccgccc attgacgtca ataatgacgt atgttcccat agtaacgcca atagggactt      420

tccattgacg tcaatgggtg gagtatttac ggtaaactgc ccacttggca gtacatcaag      480

tgtatcatat gccaagtacg ccccctattg acgtcaatga cggtaaatgg cccgcctggc      540

attatgccca gtacatgacc ttatgggact ttcctacttg gcagtacatc tacgtattag      600

tcatcgctat taccatggtg atgcggtttt ggcagtacat caatgggcgt ggatagcggt      660

ttgactcacg gggatttcca agtctccacc ccattgacgt caatgggagt ttgttttggc      720

accaaaatca acgggacttt ccaaaatgtc gtaacaactc cgccccattg acgcaaatgg      780

gcggtaggcg tgtacggtgg gaggtctata taagcagcgc gttttgcctg tactgggtct      840

ctctggttag accagatctg agcctgggag ctctctggct aactagggaa cccactgctt      900

aagcctcaat aaagcttgcc ttgagtgctt caagtagtgt gtgcccgtct gttgtgtgac      960

tctggtaact agagatccct cagacccttt tagtcagtgt ggaaaatctc tagcagtggc     1020

gcccgaacag ggacttgaaa gcgaaaggga aaccagagga gctctctcga cgcaggactc     1080

ggcttgctga agcgcgcacg gcaagaggcg aggggcggcg actggtgagt acgccaaaaa     1140

ttttgactag cggaggctag aaggagagag atgggtgcga gagcgtcagt attaagcggg     1200

ggagaattag atcgcgatgg gaaaaaattc ggttaaggcc agggggaaag aaaaaatata     1260

aattaaaaca tatagtatgg gcaagcaggg agctagaacg attcgcagtt aatcctggcc     1320

tgttagaaac atcagaaggc tgtagacaaa tactgggaca gctacaacca tcccttcaga     1380

caggatcaga agaacttaga tcattatata atacagtagc aaccctctat tgtgtgcatc     1440

aaaggataga gataaaagac accaaggaag ctttagacaa gatagaggaa gagcaaaaca     1500

aaagtaagac caccgcacag caagcggccg ctgatcttca gacctggagg aggagatatg     1560

agggacaatt ggagaagtga attatataaa tataaagtag taaaaattga accattagga     1620

gtagcaccca ccaaggcaaa gagaagagtg gtgcagagag aaaaaagagc agtgggaata     1680

ggagctttgt tccttgggtt cttgggagca gcaggaagca ctatgggcgc agcgtcaatg     1740

acgctgacgg tacaggccag acaattattg tctggtatag tgcagcagca gaacaatttg     1800

ctgagggcta ttgaggcgca acagcatctg ttgcaactca cagtctgggg catcaagcag     1860

ctccaggcaa gaatcctggc tgtggaaaga tacctaaagg atcaacagct cctggggatt     1920

tggggttgct ctggaaaact catttgcacc actgctgtgc cttggaatgc tagttggagt     1980

aataaatctc tggaacagat ttggaatcac acgacctgga tggagtggga cagagaaatt     2040

aacaattaca caagcttaat acactcctta attgaagaat cgcaaaacca gcaagaaaag     2100

aatgaacaag aattattgga attagataaa tgggcaagtt tgtggaattg gtttaacata     2160

acaaattggc tgtggtatat aaaattattc ataatgatag taggaggctt ggtaggttta     2220

agaatagttt ttgctgtact ttctatagtg aatagagtta ggcagggata ttcaccatta     2280

tcgtttcaga cccacctccc aaccccgagg ggacccgaca ggcccgaagg aatagaagaa     2340

gaaggtggag agagagacag agacagatcc attcgattag tgaacggatc ggcactgcgt     2400

gcgccaattc tgcagacaaa tggcagtatt catccacaat tttaaaagaa aaggggggat     2460

tggggggtac agtgcagggg aaagaatagt agacataata gcaacagaca tacaaactaa     2520

agaattacaa aaacaaatta caaaaattca aaattttcgg gtttattaca gggacagcag     2580

agatccagtt tggttaatta gctagctagg tcttgaaagg agtgggaatt ggctccggtg     2640

cccgtcagtg ggcagagcgc acatcgccca cagtccccga gaagttgggg ggaggggtcg     2700

gcaattgatc cggtgcctag agaaggtggc gcggggtaaa ctgggaaagt gatgtcgtgt     2760

actggctccg cctttttccc gagggtgggg gagaaccgta tataagtgca gtagtcgccg     2820

tgaacgttct ttttcgcaac gggtttgccg ccagaacaca ggaccggttc tagagcgctt     2880

taattaagcc accatggccc tgccggtgac agccctgtta ctgcctctgg ccctgctgct     2940

tcatgccgcc aggcctcaaa tccagctggt gcagtccggc cccgaactga agaagcccgg     3000

agagaccgtg aagatcagct gcaaggcctc agggtacaca tttacaaact acggcatgaa     3060

ctgggtgaaa caggcccctg gcaagggact gaagtggatg ggctggatca acaccaagac     3120

aggcgagcct acatacgccg aagagttcaa gggacggttt gcctttagct tggagacctc     3180

tgctagtacc gcttacctgc agatcaacaa cctgaaaaaa gaggacaccg ccacctactt     3240

ctgcggcaga ggcgggtacg gcagcagcta ctggtacttc gacgtgtggg gagccggcac     3300

taccgtgact gtgagcagcg ccagcaccaa gggccctagc ggcggcggcg gcagcggagg     3360

cggcggatct gggggcggcg gctcaggcgg cggaggtagc gacatcgtga tgacccagag     3420

ccataagttc atgagcacaa gcgtgggcga cagagtgagc atcacatgta aggcctccca     3480

ggacgtctct atcgccgtgg cctggtacca gcagaagcct ggccagagcc ctaaggtgct     3540

gatctatagc gccagctaca gatacacggg agtgccagat agattcacag gcagcgggtc     3600

tggtacagac ttcaccttca ccataagcag agtgcaggcc gaggacctgg ccgtctacta     3660

ctgccagcag cactacatca cccctctgac cttcggcgct ggcaccaagc tggaactgaa     3720

gcgcaccgtc gctatcgagg tgatgtaccc tccaccttac ctggacaacg agaagagtaa     3780

tggcaccatc atccacgtga agggcaagca cctgtgcccc agccccctgt ttcctggccc     3840

ctccaaaccc ttctgggtgc tggtggtggt gggcggcgtg ctggcctgct atagcctgct     3900

ggtcaccgtg gcattcatta ttttctgggt gtacagagtg gacctggtgc tgttctacag     3960

acacctgacc cggagagacg agacactgac agatggcaaa acctacgacg ccttcgtgag     4020

ctacctgaag gaatgcagac ctgagaacgg agaagagcac accttcgccg tggaaatcct     4080

gcccagagtc ctggaaaagc atttcggcta caagctttgc atcttcgagc gggacgtggt     4140

ccccgggggc gccgtggtgg acgagatcca cagcctgatc gagaagtcac gaagactgat     4200

catcgtgctg agcaagagct acatgagcaa cgaagtgcgg tacgagctgg aaagcggcct     4260

gcacgaagcc cttgtcgaga gaaagatcaa gatcatcctg atcgagttca cccctgtgac     4320

agatttcacc ttcctgcctc agtcactgaa actgctcaag agccacagag tgctgaagtg     4380

gaaagccgat aagtccctca gctacaactc tcggttctgg aagaacctgc tctatctgat     4440

gcccgccaag actgttaagc ctggcagaga tgagcctgag gtactccctg tgctgagcga     4500

gtcgggatct ggcgagggca gaggcagcct gctgacgtgc ggcgatgtcg aggaaaaccc     4560

cggtcccatg gccctgcctg tgacagccct gctgctgcca ctggccctgc tcctgcacgc     4620

cgccagacct caggtgcagc tccagcagag cggcccagaa ctcgtgcggc ctggaacatc     4680

cgtgagaatc tcgtgcaagg ccagtggcta caccttcacc atctactggc tgggctgggt     4740

gaagcaaaga ccaggccacg gcctggaatg gatcggcaac atcttccccg gctctgccta     4800

catcaactat aatgagaagt tcaaaggcaa ggccacactg accgccgaca cctctagctc     4860

taccgcctac atgcagctga gcagcctgac aagcgaggat agcgccgtgt acttctgcgc     4920

ccgagaaggc agcaacagcg gctattgggg ccaaggcaca acactcaccg tgtctagcgg     4980

cggcggcggc agcggaggcg gtggctctgg cggcggcggc tctggcggag gaggcagcga     5040

tatcgtgatg actcagagcc ctagctcgct aagcgtgagc gccggcgaga aagtgaccat     5100

gacctgtaaa agcagccaga gcctgctgaa cagtggaaat cagcagaact atctggcttg     5160

gtatcagcaa aagcctggac agcctcctaa gctgctgata tacggcgcct ccaccagaga     5220

gagcggtgtc cctgaccggt tcacaggttc tggcagcggc accgacttta ccctgaccat     5280

caactccgtg caagctgaag atctggccgt gtactactgt cagtccgacc acatctaccc     5340

ctacacattc ggaggaggca ccaagctaga aatcaagatc gaggtgatgt accctccacc     5400

atacctggac aacgagaaga gtaatggcac gatcatccac gtgaagggca agcacctgtg     5460

tcctagcccc ctgttcccag gcccaagcaa gcctttctgg gtgctggtcg tggtcggagg     5520

cgtgctggct tgttacagcc tgctggttac cgtggccttc atcatctttt gggtgagcgc     5580

cctgctgtac cgccactgga tcgaaatcgt gctgttgtac agaacctacc agtccaagga     5640

ccagaccctt ggcgacaaga aagattttga tgccttcgtg tcttacgcta aatggtccag     5700

cttccctagc gaagccacaa gttctctatc tgaggagcac ctggccctgt ctctgttccc     5760

cgatgtgctg gaaaacaagt acggctacag cctgtgcctg ctggaacggg acgtggcccc     5820

tggtggagtg tatgccgagg acatcgtgag cattatcaaa agaagcagac ggggcatctt     5880

tattctgtct cctaattacg tgaacggccc aagcattttt gagctgcagg ctgctgtgaa     5940

cctggccctg gacgaccaga ccctgaagct gatcctgatc aagttctgct actttcagga     6000

gcctgagagc ctgccgcacc tggtgaagaa ggccctgcgg gttctgccaa ccgtgacctg     6060

gcggggcctg aagagcgtgc ctcctaacag caggttctgg gccaagatga gataccacat     6120

gcctgtgaaa aactcccaag gcttcacctg gaaccaactg agaatcacct ctagaatctt     6180

ccagtggaag ggcctgagcc ggaccgagac aaccggcaga tcttctcagc caaaagagtg     6240

gtgataagaa ttcgatatca agcttatcgg taatcaacct ctggattaca aaatttgtga     6300

aagattgact ggtattctta actatgttgc tccttttacg ctatgtggat acgctgcttt     6360

aatgcctttg tatcatgcta ttgcttcccg tatggctttc attttctcct ccttgtataa     6420

atcctggttg ctgtctcttt atgaggagtt gtggcccgtt gtcaggcaac gtggcgtggt     6480

gtgcactgtg tttgctgacg caacccccac tggttggggc attgccacca cctgtcagct     6540

cctttccggg actttcgctt tccccctccc tattgccacg gcggaactca tcgccgcctg     6600

ccttgcccgc tgctggacag gggctcggct gttgggcact gacaattccg tggtgttgtc     6660

ggggaaatca tcgtcctttc cttggctgct cgcctgtgtt gccacctgga ttctgcgcgg     6720

gacgtccttc tgctacgtcc cttcggccct caatccagcg gaccttcctt cccgcggcct     6780

gctgccggct ctgcggcctc ttccgcgtct tcgccttcgc cctcagacga gtcggatctc     6840

cctttgggcc gcctccccgc atcgataccg tcgacctcga gacctagaaa aacatggagc     6900

aatcacaagt agcaatacag cagctaccaa tgctgattgt gcctggctag aagcacaaga     6960

ggaggaggag gtgggttttc cagtcacacc tcaggtacct ttaagaccaa tgacttacaa     7020

ggcagctgta gatcttagcc actttttaaa agaaaagggg ggactggaag ggctaattca     7080

ctcccaacga agacaagata tccttgatct gtggatctac cacacacaag gctacttccc     7140

tgattggcag aactacacac cagggccagg gatcagatat ccactgacct ttggatggtg     7200

ctacaagcta gtaccagttg agcaagagaa ggtagaagaa gccaatgaag gagagaacac     7260

ccgcttgtta caccctgtga gcctgcatgg gatggatgac ccggagagag aagtattaga     7320

gtggaggttt gacagccgcc tagcatttca tcacatggcc cgagagctgc atccggactg     7380

tactgggtct ctctggttag accagatctg agcctgggag ctctctggct aactagggaa     7440

cccactgctt aagcctcaat aaagcttgcc ttgagtgctt caagtagtgt gtgcccgtct     7500

gttgtgtgac tctggtaact agagatccct cagacccttt tagtcagtgt ggaaaatctc     7560

tagcagggcc cgtttaaacc cgctgatcag cctcgactgt gccttctagt tgccagccat     7620

ctgttgtttg cccctccccc gtgccttcct tgaccctgga aggtgccact cccactgtcc     7680

tttcctaata aaatgaggaa attgcatcgc attgtctgag taggtgtcat tctattctgg     7740

ggggtggggt ggggcaggac agcaaggggg aggattggga agacaatagc aggcatgctg     7800

gggatgcggt gggctctatg gcttctgagg cggaaagaac cagctggggc tctagggggt     7860

atccccacgc gccctgtagc ggcgcattaa gcgcggcggg tgtggtggtt acgcgcagcg     7920

tgaccgctac acttgccagc gccctagcgc ccgctccttt cgctttcttc ccttcctttc     7980

tcgccacgtt cgccggcttt ccccgtcaag ctctaaatcg ggggctccct ttagggttcc     8040

gatttagtgc tttacggcac ctcgacccca aaaaacttga ttagggtgat ggttcacgta     8100

gtgggccatc gccctgatag acggtttttc gccctttgac gttggagtcc acgttcttta     8160

atagtggact cttgttccaa actggaacaa cactcaaccc tatctcggtc tattcttttg     8220

atttataagg gattttgccg atttcggcct attggttaaa aaatgagctg atttaacaaa     8280

aatttaacgc gaattaattc tgtggaatgt gtgtcagtta gggtgtggaa agtccccagg     8340

ctccccagca ggcagaagta tgcaaagcat gcatctcaat tagtcagcaa ccaggtgtgg     8400

aaagtcccca ggctccccag caggcagaag tatgcaaagc atgcatctca attagtcagc     8460

aaccatagtc ccgcccctaa ctccgcccat cccgccccta actccgccca gttccgccca     8520

ttctccgccc catggctgac taattttttt tatttatgca gaggccgagg ccgcctctgc     8580

ctctgagcta ttccagaagt agtgaggagg cttttttgga ggcctaggct tttgcaaaaa     8640

gctcccggga gcttgtatat ccattttcgg atctgatcag cacgtgttga caattaatca     8700

tcggcatagt atatcggcat agtataatac gacaaggtga ggaactaaac catggccaag     8760

ttgaccagtg ccgttccggt gctcaccgcg cgcgacgtcg ccggagcggt cgagttctgg     8820

accgaccggc tcgggttctc ccgggacttc gtggaggacg acttcgccgg tgtggtccgg     8880

gacgacgtga ccctgttcat cagcgcggtc caggaccagg tggtgccgga caacaccctg     8940

gcctgggtgt gggtgcgcgg cctggacgag ctgtacgccg agtggtcgga ggtcgtgtcc     9000

acgaacttcc gggacgcctc cgggccggcc atgaccgaga tcggcgagca gccgtggggg     9060

cgggagttcg ccctgcgcga cccggccggc aactgcgtgc acttcgtggc cgaggagcag     9120

gactgacacg tgctacgaga tttcgattcc accgccgcct tctatgaaag gttgggcttc     9180

ggaatcgttt tccgggacgc cggctggatg atcctccagc gcggggatct catgctggag     9240

ttcttcgccc accccaactt gtttattgca gcttataatg gttacaaata aagcaatagc     9300

atcacaaatt tcacaaataa agcatttttt tcactgcatt ctagttgtgg tttgtccaaa     9360

ctcatcaatg tatcttatca tgtctgtata ccgtcgacct ctagctagag cttggcgtaa     9420

tcatggtcat agctgtttcc tgtgtgaaat tgttatccgc tcacaattcc acacaacata     9480

cgagccggaa gcataaagtg taaagcctgg ggtgcctaat gagtgagcta actcacatta     9540

attgcgttgc gctcactgcc cgctttccag tcgggaaacc tgtcgtgcca gctgcattaa     9600

tgaatcggcc aacgcgcggg gagaggcggt ttgcgtattg ggcgctcttc cgcttcctcg     9660

ctcactgact cgctgcgctc ggtcgttcgg ctgcggcgag cggtatcagc tcactcaaag     9720

gcggtaatac ggttatccac agaatcaggg gataacgcag gaaagaacat gtgagcaaaa     9780

ggccagcaaa aggccaggaa ccgtaaaaag gccgcgttgc tggcgttttt ccataggctc     9840

cgcccccctg acgagcatca caaaaatcga cgctcaagtc agaggtggcg aaacccgaca     9900

ggactataaa gataccaggc gtttccccct ggaagctccc tcgtgcgctc tcctgttccg     9960

accctgccgc ttaccggata cctgtccgcc tttctccctt cgggaagcgt ggcgctttct    10020

catagctcac gctgtaggta tctcagttcg gtgtaggtcg ttcgctccaa gctgggctgt    10080

gtgcacgaac cccccgttca gcccgaccgc tgcgccttat ccggtaacta tcgtcttgag    10140

tccaacccgg taagacacga cttatcgcca ctggcagcag ccactggtaa caggattagc    10200

agagcgaggt atgtaggcgg tgctacagag ttcttgaagt ggtggcctaa ctacggctac    10260

actagaagaa cagtatttgg tatctgcgct ctgctgaagc cagttacctt cggaaaaaga    10320

gttggtagct cttgatccgg caaacaaacc accgctggta gcggtggttt ttttgtttgc    10380

aagcagcaga ttacgcgcag aaaaaaagga tctcaagaag atcctttgat cttttctacg    10440

gggtctgacg ctcagtggaa cgaaaactca cgttaaggga ttttggtcat gagattatca    10500

aaaaggatct tcacctagat ccttttaaat taaaaatgaa gttttaaatc aatctaaagt    10560

atatatgagt aaacttggtc tgacagttac caatgcttaa tcagtgaggc acctatctca    10620

gcgatctgtc tatttcgttc atccatagtt gcctgactcc ccgtcgtgta gataactacg    10680

atacgggagg gcttaccatc tggccccagt gctgcaatga taccgcgaga cccacgctca    10740

ccggctccag atttatcagc aataaaccag ccagccggaa gggccgagcg cagaagtggt    10800

cctgcaactt tatccgcctc catccagtct attaattgtt gccgggaagc tagagtaagt    10860

agttcgccag ttaatagttt gcgcaacgtt gttgccattg ctacaggcat cgtggtgtca    10920

cgctcgtcgt ttggtatggc ttcattcagc tccggttccc aacgatcaag gcgagttaca    10980

tgatccccca tgttgtgcaa aaaagcggtt agctccttcg gtcctccgat cgttgtcaga    11040

agtaagttgg ccgcagtgtt atcactcatg gttatggcag cactgcataa ttctcttact    11100

gtcatgccat ccgtaagatg cttttctgtg actggtgagt actcaaccaa gtcattctga    11160

gaatagtgta tgcggcgacc gagttgctct tgcccggcgt caatacggga taataccgcg    11220

ccacatagca gaactttaaa agtgctcatc attggaaaac gttcttcggg gcgaaaactc    11280

tcaaggatct taccgctgtt gagatccagt tcgatgtaac ccactcgtgc acccaactga    11340

tcttcagcat cttttacttt caccagcgtt tctgggtgag caaaaacagg aaggcaaaat    11400

gccgcaaaaa agggaataag ggcgacacgg aaatgttgaa tactcatact cttccttttt    11460

caatattatt gaagcattta tcagggttat tgtctcatga gcggatacat atttgaatgt    11520

atttagaaaa ataaacaaat aggggttccg cgcacatttc cccgaaaagt gccacctgac    11580


<210>  627
<211>  350
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic amino acid

<400>  627

Met Ser Asn Ile Thr Asp Pro Gln Met Trp Asp Phe Asp Asp Leu Asn 
1               5                   10                  15      


Phe Thr Gly Met Pro Pro Ala Asp Glu Asp Tyr Ser Pro Cys Met Leu 
            20                  25                  30          


Glu Thr Glu Thr Leu Asn Lys Tyr Val Val Ile Ile Ala Tyr Ala Leu 
        35                  40                  45              


Val Phe Leu Leu Ser Leu Leu Gly Asn Ser Leu Val Met Leu Val Ile 
    50                  55                  60                  


Leu Tyr Ser Arg Val Gly Arg Ser Val Thr Asp Val Tyr Leu Leu Asn 
65                  70                  75                  80  


Leu Ala Leu Ala Asp Leu Leu Phe Ala Leu Thr Leu Pro Ile Trp Ala 
                85                  90                  95      


Ala Ser Lys Val Asn Gly Trp Ile Phe Gly Thr Phe Leu Cys Lys Val 
            100                 105                 110         


Val Ser Leu Leu Lys Glu Val Asn Phe Tyr Ser Gly Ile Leu Leu Leu 
        115                 120                 125             


Ala Cys Ile Ser Val Asp Arg Tyr Leu Ala Ile Val His Ala Thr Arg 
    130                 135                 140                 


Thr Leu Thr Gln Lys Arg His Leu Val Lys Phe Val Cys Leu Gly Cys 
145                 150                 155                 160 


Trp Gly Leu Ser Met Asn Leu Ser Leu Pro Phe Phe Leu Phe Arg Gln 
                165                 170                 175     


Ala Tyr His Pro Asn Asn Ser Ser Pro Val Cys Tyr Glu Val Leu Gly 
            180                 185                 190         


Asn Asp Thr Ala Lys Trp Arg Met Val Leu Arg Ile Leu Pro His Thr 
        195                 200                 205             


Phe Gly Phe Ile Val Pro Leu Phe Val Met Leu Phe Cys Tyr Gly Phe 
    210                 215                 220                 


Thr Leu Arg Thr Leu Phe Lys Ala His Met Gly Gln Lys His Arg Ala 
225                 230                 235                 240 


Met Arg Val Ile Phe Ala Val Val Leu Ile Phe Leu Leu Cys Trp Leu 
                245                 250                 255     


Pro Tyr Asn Leu Val Leu Leu Ala Asp Thr Leu Met Arg Thr Gln Val 
            260                 265                 270         


Ile Gln Glu Ser Cys Glu Arg Arg Asn Asn Ile Gly Arg Ala Leu Asp 
        275                 280                 285             


Ala Thr Glu Ile Leu Gly Phe Leu His Ser Cys Leu Asn Pro Ile Ile 
    290                 295                 300                 


Tyr Ala Phe Ile Gly Gln Asn Phe Arg His Gly Phe Leu Lys Ile Leu 
305                 310                 315                 320 


Ala Met His Gly Leu Val Ser Lys Glu Phe Leu Ala Arg His Arg Val 
                325                 330                 335     


Thr Ser Tyr Thr Ser Ser Ser Val Asn Val Ser Ser Asn Leu 
            340                 345                 350 


<210>  628
<211>  360
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic amino acid

<400>  628

Met Glu Asp Phe Asn Met Glu Ser Asp Ser Phe Glu Asp Phe Trp Lys 
1               5                   10                  15      


Gly Glu Asp Leu Ser Asn Tyr Ser Tyr Ser Ser Thr Leu Pro Pro Phe 
            20                  25                  30          


Leu Leu Asp Ala Ala Pro Cys Glu Pro Glu Ser Leu Glu Ile Asn Lys 
        35                  40                  45              


Tyr Phe Val Val Ile Ile Tyr Ala Leu Val Phe Leu Leu Ser Leu Leu 
    50                  55                  60                  


Gly Asn Ser Leu Val Met Leu Val Ile Leu Tyr Ser Arg Val Gly Arg 
65                  70                  75                  80  


Ser Val Thr Asp Val Tyr Leu Leu Asn Leu Ala Leu Ala Asp Leu Leu 
                85                  90                  95      


Phe Ala Leu Thr Leu Pro Ile Trp Ala Ala Ser Lys Val Asn Gly Trp 
            100                 105                 110         


Ile Phe Gly Thr Phe Leu Cys Lys Val Val Ser Leu Leu Lys Glu Val 
        115                 120                 125             


Asn Phe Tyr Ser Gly Ile Leu Leu Leu Ala Cys Ile Ser Val Asp Arg 
    130                 135                 140                 


Tyr Leu Ala Ile Val His Ala Thr Arg Thr Leu Thr Gln Lys Arg Tyr 
145                 150                 155                 160 


Leu Val Lys Phe Ile Cys Leu Ser Ile Trp Gly Leu Ser Leu Leu Leu 
                165                 170                 175     


Ala Leu Pro Val Leu Leu Phe Arg Arg Thr Val Tyr Ser Ser Asn Val 
            180                 185                 190         


Ser Pro Ala Cys Tyr Glu Asp Met Gly Asn Asn Thr Ala Asn Trp Arg 
        195                 200                 205             


Met Leu Leu Arg Ile Leu Pro Gln Ser Phe Gly Phe Ile Val Pro Leu 
    210                 215                 220                 


Leu Ile Met Leu Phe Cys Tyr Gly Phe Thr Leu Arg Thr Leu Phe Lys 
225                 230                 235                 240 


Ala His Met Gly Gln Lys His Arg Ala Met Arg Val Ile Phe Ala Val 
                245                 250                 255     


Val Leu Ile Phe Leu Leu Cys Trp Leu Pro Tyr Asn Leu Val Leu Leu 
            260                 265                 270         


Ala Asp Thr Leu Met Arg Thr Gln Val Ile Gln Glu Thr Cys Glu Arg 
        275                 280                 285             


Arg Asn His Ile Asp Arg Ala Leu Asp Ala Thr Glu Ile Leu Gly Ile 
    290                 295                 300                 


Leu His Ser Cys Leu Asn Pro Leu Ile Tyr Ala Phe Ile Gly Gln Lys 
305                 310                 315                 320 


Phe Arg His Gly Leu Leu Lys Ile Leu Ala Ile His Gly Leu Ile Ser 
                325                 330                 335     


Lys Asp Ser Leu Pro Lys Asp Ser Arg Pro Ser Phe Val Gly Ser Ser 
            340                 345                 350         


Ser Gly His Thr Ser Thr Thr Leu 
        355                 360 


<210>  629
<211>  368
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic amino acid

<400>  629

Met Val Leu Glu Val Ser Asp His Gln Val Leu Asn Asp Ala Glu Val 
1               5                   10                  15      


Ala Ala Leu Leu Glu Asn Phe Ser Ser Ser Tyr Asp Tyr Gly Glu Asn 
            20                  25                  30          


Glu Ser Asp Ser Cys Cys Thr Ser Pro Pro Cys Pro Gln Asp Phe Ser 
        35                  40                  45              


Leu Asn Phe Asp Arg Ala Phe Leu Pro Ala Leu Tyr Ser Leu Leu Phe 
    50                  55                  60                  


Leu Leu Gly Leu Leu Gly Asn Gly Ala Val Ala Ala Val Leu Leu Ser 
65                  70                  75                  80  


Arg Arg Thr Ala Leu Ser Ser Thr Asp Thr Phe Leu Leu His Leu Ala 
                85                  90                  95      


Val Ala Asp Thr Leu Leu Val Leu Thr Leu Pro Leu Trp Ala Val Asp 
            100                 105                 110         


Ala Ala Val Gln Trp Val Phe Gly Ser Gly Leu Cys Lys Val Ala Gly 
        115                 120                 125             


Ala Leu Phe Asn Ile Asn Phe Tyr Ala Gly Ala Leu Leu Leu Ala Cys 
    130                 135                 140                 


Ile Ser Phe Asp Arg Tyr Leu Asn Ile Val His Ala Thr Gln Leu Tyr 
145                 150                 155                 160 


Arg Arg Gly Pro Pro Ala Arg Val Thr Leu Thr Cys Leu Ala Val Trp 
                165                 170                 175     


Gly Leu Cys Leu Leu Phe Ala Leu Pro Asp Phe Ile Phe Leu Ser Ala 
            180                 185                 190         


His His Asp Glu Arg Leu Asn Ala Thr His Cys Gln Tyr Asn Phe Pro 
        195                 200                 205             


Gln Val Gly Arg Thr Ala Leu Arg Val Leu Gln Leu Val Ala Gly Phe 
    210                 215                 220                 


Leu Leu Pro Leu Leu Val Met Ala Tyr Cys Tyr Ala His Ile Leu Ala 
225                 230                 235                 240 


Val Leu Leu Val Ser Arg Gly Gln Arg Arg Leu Arg Ala Met Arg Leu 
                245                 250                 255     


Val Val Val Val Val Val Ala Phe Ala Leu Cys Trp Thr Pro Tyr His 
            260                 265                 270         


Leu Val Val Leu Val Asp Ile Leu Met Asp Leu Gly Ala Leu Ala Arg 
        275                 280                 285             


Asn Cys Gly Arg Glu Ser Arg Val Asp Val Ala Lys Ser Val Thr Ser 
    290                 295                 300                 


Gly Leu Gly Tyr Met His Cys Cys Leu Asn Pro Leu Leu Tyr Ala Phe 
305                 310                 315                 320 


Val Gly Val Lys Phe Arg Glu Arg Met Trp Met Leu Leu Leu Arg Leu 
                325                 330                 335     


Gly Cys Pro Asn Gln Arg Gly Leu Gln Arg Gln Pro Ser Ser Ser Arg 
            340                 345                 350         


Arg Asp Ser Ser Trp Ser Glu Thr Ser Glu Ala Ser Tyr Ser Gly Leu 
        355                 360                 365             


<210>  630
<211>  415
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic amino acid

<400>  630

Met Glu Leu Arg Lys Tyr Gly Pro Gly Arg Leu Ala Gly Thr Val Ile 
1               5                   10                  15      


Gly Gly Ala Ala Gln Ser Lys Ser Gln Thr Lys Ser Asp Ser Ile Thr 
            20                  25                  30          


Lys Glu Phe Leu Pro Gly Leu Tyr Thr Ala Pro Ser Ser Pro Phe Pro 
        35                  40                  45              


Pro Ser Gln Val Ser Asp His Gln Val Leu Asn Asp Ala Glu Val Ala 
    50                  55                  60                  


Ala Leu Leu Glu Asn Phe Ser Ser Ser Tyr Asp Tyr Gly Glu Asn Glu 
65                  70                  75                  80  


Ser Asp Ser Cys Cys Thr Ser Pro Pro Cys Pro Gln Asp Phe Ser Leu 
                85                  90                  95      


Asn Phe Asp Arg Ala Phe Leu Pro Ala Leu Tyr Ser Leu Leu Phe Leu 
            100                 105                 110         


Leu Gly Leu Leu Gly Asn Gly Ala Val Ala Ala Val Leu Leu Ser Arg 
        115                 120                 125             


Arg Thr Ala Leu Ser Ser Thr Asp Thr Phe Leu Leu His Leu Ala Val 
    130                 135                 140                 


Ala Asp Thr Leu Leu Val Leu Thr Leu Pro Leu Trp Ala Val Asp Ala 
145                 150                 155                 160 


Ala Val Gln Trp Val Phe Gly Ser Gly Leu Cys Lys Val Ala Gly Ala 
                165                 170                 175     


Leu Phe Asn Ile Asn Phe Tyr Ala Gly Ala Leu Leu Leu Ala Cys Ile 
            180                 185                 190         


Ser Phe Asp Arg Tyr Leu Asn Ile Val His Ala Thr Gln Leu Tyr Arg 
        195                 200                 205             


Arg Gly Pro Pro Ala Arg Val Thr Leu Thr Cys Leu Ala Val Trp Gly 
    210                 215                 220                 


Leu Cys Leu Leu Phe Ala Leu Pro Asp Phe Ile Phe Leu Ser Ala His 
225                 230                 235                 240 


His Asp Glu Arg Leu Asn Ala Thr His Cys Gln Tyr Asn Phe Pro Gln 
                245                 250                 255     


Val Gly Arg Thr Ala Leu Arg Val Leu Gln Leu Val Ala Gly Phe Leu 
            260                 265                 270         


Leu Pro Leu Leu Val Met Ala Tyr Cys Tyr Ala His Ile Leu Ala Val 
        275                 280                 285             


Leu Leu Val Ser Arg Gly Gln Arg Arg Leu Arg Ala Met Arg Leu Val 
    290                 295                 300                 


Val Val Val Val Val Ala Phe Ala Leu Cys Trp Thr Pro Tyr His Leu 
305                 310                 315                 320 


Val Val Leu Val Asp Ile Leu Met Asp Leu Gly Ala Leu Ala Arg Asn 
                325                 330                 335     


Cys Gly Arg Glu Ser Arg Val Asp Val Ala Lys Ser Val Thr Ser Gly 
            340                 345                 350         


Leu Gly Tyr Met His Cys Cys Leu Asn Pro Leu Leu Tyr Ala Phe Val 
        355                 360                 365             


Gly Val Lys Phe Arg Glu Arg Met Trp Met Leu Leu Leu Arg Leu Gly 
    370                 375                 380                 


Cys Pro Asn Gln Arg Gly Leu Gln Arg Gln Pro Ser Ser Ser Arg Arg 
385                 390                 395                 400 


Asp Ser Ser Trp Ser Glu Thr Ser Glu Ala Ser Tyr Ser Gly Leu 
                405                 410                 415 


<210>  631
<211>  356
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic amino acid

<400>  631

Met Ser Ile Pro Leu Pro Leu Leu Gln Ile Tyr Thr Ser Asp Asn Tyr 
1               5                   10                  15      


Thr Glu Glu Met Gly Ser Gly Asp Tyr Asp Ser Met Lys Glu Pro Cys 
            20                  25                  30          


Phe Arg Glu Glu Asn Ala Asn Phe Asn Lys Ile Phe Leu Pro Thr Ile 
        35                  40                  45              


Tyr Ser Ile Ile Phe Leu Thr Gly Ile Val Gly Asn Gly Leu Val Ile 
    50                  55                  60                  


Leu Val Met Gly Tyr Gln Lys Lys Leu Arg Ser Met Thr Asp Lys Tyr 
65                  70                  75                  80  


Arg Leu His Leu Ser Val Ala Asp Leu Leu Phe Val Ile Thr Leu Pro 
                85                  90                  95      


Phe Trp Ala Val Asp Ala Val Ala Asn Trp Tyr Phe Gly Asn Phe Leu 
            100                 105                 110         


Cys Lys Ala Val His Val Ile Tyr Thr Val Asn Leu Tyr Ser Ser Val 
        115                 120                 125             


Leu Ile Leu Ala Phe Ile Ser Leu Asp Arg Tyr Leu Ala Ile Val His 
    130                 135                 140                 


Ala Thr Asn Ser Gln Arg Pro Arg Lys Leu Leu Ala Glu Lys Val Val 
145                 150                 155                 160 


Tyr Val Gly Val Trp Ile Pro Ala Leu Leu Leu Thr Ile Pro Asp Phe 
                165                 170                 175     


Ile Phe Ala Asn Val Ser Glu Ala Asp Asp Arg Tyr Ile Cys Asp Arg 
            180                 185                 190         


Phe Tyr Pro Asn Asp Leu Trp Val Val Val Phe Gln Phe Gln His Ile 
        195                 200                 205             


Met Val Gly Leu Ile Leu Pro Gly Ile Val Ile Leu Ser Cys Tyr Cys 
    210                 215                 220                 


Ile Ile Ile Ser Lys Leu Ser His Ser Lys Gly His Gln Lys Arg Lys 
225                 230                 235                 240 


Ala Leu Lys Thr Thr Val Ile Leu Ile Leu Ala Phe Phe Ala Cys Trp 
                245                 250                 255     


Leu Pro Tyr Tyr Ile Gly Ile Ser Ile Asp Ser Phe Ile Leu Leu Glu 
            260                 265                 270         


Ile Ile Lys Gln Gly Cys Glu Phe Glu Asn Thr Val His Lys Trp Ile 
        275                 280                 285             


Ser Ile Thr Glu Ala Leu Ala Phe Phe His Cys Cys Leu Asn Pro Ile 
    290                 295                 300                 


Leu Tyr Ala Phe Leu Gly Ala Lys Phe Lys Thr Ser Ala Gln His Ala 
305                 310                 315                 320 


Leu Thr Ser Val Ser Arg Gly Ser Ser Leu Lys Ile Leu Ser Lys Gly 
                325                 330                 335     


Lys Arg Gly Gly His Ser Ser Val Ser Thr Glu Ser Glu Ser Ser Ser 
            340                 345                 350         


Phe His Ser Ser 
        355     


<210>  632
<211>  352
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic amino acid

<400>  632

Met Glu Gly Ile Ser Ile Tyr Thr Ser Asp Asn Tyr Thr Glu Glu Met 
1               5                   10                  15      


Gly Ser Gly Asp Tyr Asp Ser Met Lys Glu Pro Cys Phe Arg Glu Glu 
            20                  25                  30          


Asn Ala Asn Phe Asn Lys Ile Phe Leu Pro Thr Ile Tyr Ser Ile Ile 
        35                  40                  45              


Phe Leu Thr Gly Ile Val Gly Asn Gly Leu Val Ile Leu Val Met Gly 
    50                  55                  60                  


Tyr Gln Lys Lys Leu Arg Ser Met Thr Asp Lys Tyr Arg Leu His Leu 
65                  70                  75                  80  


Ser Val Ala Asp Leu Leu Phe Val Ile Thr Leu Pro Phe Trp Ala Val 
                85                  90                  95      


Asp Ala Val Ala Asn Trp Tyr Phe Gly Asn Phe Leu Cys Lys Ala Val 
            100                 105                 110         


His Val Ile Tyr Thr Val Asn Leu Tyr Ser Ser Val Leu Ile Leu Ala 
        115                 120                 125             


Phe Ile Ser Leu Asp Arg Tyr Leu Ala Ile Val His Ala Thr Asn Ser 
    130                 135                 140                 


Gln Arg Pro Arg Lys Leu Leu Ala Glu Lys Val Val Tyr Val Gly Val 
145                 150                 155                 160 


Trp Ile Pro Ala Leu Leu Leu Thr Ile Pro Asp Phe Ile Phe Ala Asn 
                165                 170                 175     


Val Ser Glu Ala Asp Asp Arg Tyr Ile Cys Asp Arg Phe Tyr Pro Asn 
            180                 185                 190         


Asp Leu Trp Val Val Val Phe Gln Phe Gln His Ile Met Val Gly Leu 
        195                 200                 205             


Ile Leu Pro Gly Ile Val Ile Leu Ser Cys Tyr Cys Ile Ile Ile Ser 
    210                 215                 220                 


Lys Leu Ser His Ser Lys Gly His Gln Lys Arg Lys Ala Leu Lys Thr 
225                 230                 235                 240 


Thr Val Ile Leu Ile Leu Ala Phe Phe Ala Cys Trp Leu Pro Tyr Tyr 
                245                 250                 255     


Ile Gly Ile Ser Ile Asp Ser Phe Ile Leu Leu Glu Ile Ile Lys Gln 
            260                 265                 270         


Gly Cys Glu Phe Glu Asn Thr Val His Lys Trp Ile Ser Ile Thr Glu 
        275                 280                 285             


Ala Leu Ala Phe Phe His Cys Cys Leu Asn Pro Ile Leu Tyr Ala Phe 
    290                 295                 300                 


Leu Gly Ala Lys Phe Lys Thr Ser Ala Gln His Ala Leu Thr Ser Val 
305                 310                 315                 320 


Ser Arg Gly Ser Ser Leu Lys Ile Leu Ser Lys Gly Lys Arg Gly Gly 
                325                 330                 335     


His Ser Ser Val Ser Thr Glu Ser Glu Ser Ser Ser Phe His Ser Ser 
            340                 345                 350         


<210>  633
<211>  423
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic amino acid

<400>  633

Met Glu Gly Ile Ser Glu Asn Ala Pro Leu Pro Asn Val Pro Asn Ala 
1               5                   10                  15      


Pro Ser Asp Lys His Glu Asp Gly Lys Arg Pro Thr His Arg Arg Ser 
            20                  25                  30          


Ala Arg Leu Gly Glu Glu Val Pro Phe Val His Phe Leu Thr Leu Pro 
        35                  40                  45              


Pro Asn Ile Pro Gln Ala Pro Lys Gly Leu Arg Phe Lys Thr Ala Phe 
    50                  55                  60                  


Ser Leu Pro Thr Thr Ser Cys Leu Lys Pro Arg Met Ile Tyr Thr Ser 
65                  70                  75                  80  


Asp Asn Tyr Thr Glu Glu Met Gly Ser Gly Asp Tyr Asp Ser Met Lys 
                85                  90                  95      


Glu Pro Cys Phe Arg Glu Glu Asn Ala Asn Phe Asn Lys Ile Phe Leu 
            100                 105                 110         


Pro Thr Ile Tyr Ser Ile Ile Phe Leu Thr Gly Ile Val Gly Asn Gly 
        115                 120                 125             


Leu Val Ile Leu Val Met Gly Tyr Gln Lys Lys Leu Arg Ser Met Thr 
    130                 135                 140                 


Asp Lys Tyr Arg Leu His Leu Ser Val Ala Asp Leu Leu Phe Val Ile 
145                 150                 155                 160 


Thr Leu Pro Phe Trp Ala Val Asp Ala Val Ala Asn Trp Tyr Phe Gly 
                165                 170                 175     


Asn Phe Leu Cys Lys Ala Val His Val Ile Tyr Thr Val Asn Leu Tyr 
            180                 185                 190         


Ser Ser Val Leu Ile Leu Ala Phe Ile Ser Leu Asp Arg Tyr Leu Ala 
        195                 200                 205             


Ile Val His Ala Thr Asn Ser Gln Arg Pro Arg Lys Leu Leu Ala Glu 
    210                 215                 220                 


Lys Val Val Tyr Val Gly Val Trp Ile Pro Ala Leu Leu Leu Thr Ile 
225                 230                 235                 240 


Pro Asp Phe Ile Phe Ala Asn Val Ser Glu Ala Asp Asp Arg Tyr Ile 
                245                 250                 255     


Cys Asp Arg Phe Tyr Pro Asn Asp Leu Trp Val Val Val Phe Gln Phe 
            260                 265                 270         


Gln His Ile Met Val Gly Leu Ile Leu Pro Gly Ile Val Ile Leu Ser 
        275                 280                 285             


Cys Tyr Cys Ile Ile Ile Ser Lys Leu Ser His Ser Lys Gly His Gln 
    290                 295                 300                 


Lys Arg Lys Ala Leu Lys Thr Thr Val Ile Leu Ile Leu Ala Phe Phe 
305                 310                 315                 320 


Ala Cys Trp Leu Pro Tyr Tyr Ile Gly Ile Ser Ile Asp Ser Phe Ile 
                325                 330                 335     


Leu Leu Glu Ile Ile Lys Gln Gly Cys Glu Phe Glu Asn Thr Val His 
            340                 345                 350         


Lys Trp Ile Ser Ile Thr Glu Ala Leu Ala Phe Phe His Cys Cys Leu 
        355                 360                 365             


Asn Pro Ile Leu Tyr Ala Phe Leu Gly Ala Lys Phe Lys Thr Ser Ala 
    370                 375                 380                 


Gln His Ala Leu Thr Ser Val Ser Arg Gly Ser Ser Leu Lys Ile Leu 
385                 390                 395                 400 


Ser Lys Gly Lys Arg Gly Gly His Ser Ser Val Ser Thr Glu Ser Glu 
                405                 410                 415     


Ser Ser Ser Phe His Ser Ser 
            420             


<210>  634
<211>  385
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic amino acid

<400>  634

Met Glu Gly Ile Ser Glu Asn Ala Pro Leu Pro Asn Val Pro Asn Ala 
1               5                   10                  15      


Pro Ser Asp Lys His Glu Asp Gly Lys Arg Pro Thr His Arg Arg Ser 
            20                  25                  30          


Ala Arg Leu Gly Glu Glu Ile Tyr Thr Ser Asp Asn Tyr Thr Glu Glu 
        35                  40                  45              


Met Gly Ser Gly Asp Tyr Asp Ser Met Lys Glu Pro Cys Phe Arg Glu 
    50                  55                  60                  


Glu Asn Ala Asn Phe Asn Lys Ile Phe Leu Pro Thr Ile Tyr Ser Ile 
65                  70                  75                  80  


Ile Phe Leu Thr Gly Ile Val Gly Asn Gly Leu Val Ile Leu Val Met 
                85                  90                  95      


Gly Tyr Gln Lys Lys Leu Arg Ser Met Thr Asp Lys Tyr Arg Leu His 
            100                 105                 110         


Leu Ser Val Ala Asp Leu Leu Phe Val Ile Thr Leu Pro Phe Trp Ala 
        115                 120                 125             


Val Asp Ala Val Ala Asn Trp Tyr Phe Gly Asn Phe Leu Cys Lys Ala 
    130                 135                 140                 


Val His Val Ile Tyr Thr Val Asn Leu Tyr Ser Ser Val Leu Ile Leu 
145                 150                 155                 160 


Ala Phe Ile Ser Leu Asp Arg Tyr Leu Ala Ile Val His Ala Thr Asn 
                165                 170                 175     


Ser Gln Arg Pro Arg Lys Leu Leu Ala Glu Lys Val Val Tyr Val Gly 
            180                 185                 190         


Val Trp Ile Pro Ala Leu Leu Leu Thr Ile Pro Asp Phe Ile Phe Ala 
        195                 200                 205             


Asn Val Ser Glu Ala Asp Asp Arg Tyr Ile Cys Asp Arg Phe Tyr Pro 
    210                 215                 220                 


Asn Asp Leu Trp Val Val Val Phe Gln Phe Gln His Ile Met Val Gly 
225                 230                 235                 240 


Leu Ile Leu Pro Gly Ile Val Ile Leu Ser Cys Tyr Cys Ile Ile Ile 
                245                 250                 255     


Ser Lys Leu Ser His Ser Lys Gly His Gln Lys Arg Lys Ala Leu Lys 
            260                 265                 270         


Thr Thr Val Ile Leu Ile Leu Ala Phe Phe Ala Cys Trp Leu Pro Tyr 
        275                 280                 285             


Tyr Ile Gly Ile Ser Ile Asp Ser Phe Ile Leu Leu Glu Ile Ile Lys 
    290                 295                 300                 


Gln Gly Cys Glu Phe Glu Asn Thr Val His Lys Trp Ile Ser Ile Thr 
305                 310                 315                 320 


Glu Ala Leu Ala Phe Phe His Cys Cys Leu Asn Pro Ile Leu Tyr Ala 
                325                 330                 335     


Phe Leu Gly Ala Lys Phe Lys Thr Ser Ala Gln His Ala Leu Thr Ser 
            340                 345                 350         


Val Ser Arg Gly Ser Ser Leu Lys Ile Leu Ser Lys Gly Lys Arg Gly 
        355                 360                 365             


Gly His Ser Ser Val Ser Thr Glu Ser Glu Ser Ser Ser Phe His Ser 
    370                 375                 380                 


Ser 
385 


<210>  635
<211>  337
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic amino acid

<400>  635

Met Gly Ser Gly Asp Tyr Asp Ser Met Lys Glu Pro Cys Phe Arg Glu 
1               5                   10                  15      


Glu Asn Ala Asn Phe Asn Lys Ile Phe Leu Pro Thr Ile Tyr Ser Ile 
            20                  25                  30          


Ile Phe Leu Thr Gly Ile Val Gly Asn Gly Leu Val Ile Leu Val Met 
        35                  40                  45              


Gly Tyr Gln Lys Lys Leu Arg Ser Met Thr Asp Lys Tyr Arg Leu His 
    50                  55                  60                  


Leu Ser Val Ala Asp Leu Leu Phe Val Ile Thr Leu Pro Phe Trp Ala 
65                  70                  75                  80  


Val Asp Ala Val Ala Asn Trp Tyr Phe Gly Asn Phe Leu Cys Lys Ala 
                85                  90                  95      


Val His Val Ile Tyr Thr Val Asn Leu Tyr Ser Ser Val Leu Ile Leu 
            100                 105                 110         


Ala Phe Ile Ser Leu Asp Arg Tyr Leu Ala Ile Val His Ala Thr Asn 
        115                 120                 125             


Ser Gln Arg Pro Arg Lys Leu Leu Ala Glu Lys Val Val Tyr Val Gly 
    130                 135                 140                 


Val Trp Ile Pro Ala Leu Leu Leu Thr Ile Pro Asp Phe Ile Phe Ala 
145                 150                 155                 160 


Asn Val Ser Glu Ala Asp Asp Arg Tyr Ile Cys Asp Arg Phe Tyr Pro 
                165                 170                 175     


Asn Asp Leu Trp Val Val Val Phe Gln Phe Gln His Ile Met Val Gly 
            180                 185                 190         


Leu Ile Leu Pro Gly Ile Val Ile Leu Ser Cys Tyr Cys Ile Ile Ile 
        195                 200                 205             


Ser Lys Leu Ser His Ser Lys Gly His Gln Lys Arg Lys Ala Leu Lys 
    210                 215                 220                 


Thr Thr Val Ile Leu Ile Leu Ala Phe Phe Ala Cys Trp Leu Pro Tyr 
225                 230                 235                 240 


Tyr Ile Gly Ile Ser Ile Asp Ser Phe Ile Leu Leu Glu Ile Ile Lys 
                245                 250                 255     


Gln Gly Cys Glu Phe Glu Asn Thr Val His Lys Trp Ile Ser Ile Thr 
            260                 265                 270         


Glu Ala Leu Ala Phe Phe His Cys Cys Leu Asn Pro Ile Leu Tyr Ala 
        275                 280                 285             


Phe Leu Gly Ala Lys Phe Lys Thr Ser Ala Gln His Ala Leu Thr Ser 
    290                 295                 300                 


Val Ser Arg Gly Ser Ser Leu Lys Ile Leu Ser Lys Gly Lys Arg Gly 
305                 310                 315                 320 


Gly His Ser Ser Val Ser Thr Glu Ser Glu Ser Ser Ser Phe His Ser 
                325                 330                 335     


Ser 
    


<210>  636
<211>  372
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic amino acid

<400>  636

Met Asn Tyr Pro Leu Thr Leu Glu Met Asp Leu Glu Asn Leu Glu Asp 
1               5                   10                  15      


Leu Phe Trp Glu Leu Asp Arg Leu Asp Asn Tyr Asn Asp Thr Ser Leu 
            20                  25                  30          


Val Glu Asn His Leu Cys Pro Ala Thr Glu Gly Pro Leu Met Ala Ser 
        35                  40                  45              


Phe Lys Ala Val Phe Val Pro Val Ala Tyr Ser Leu Ile Phe Leu Leu 
    50                  55                  60                  


Gly Val Ile Gly Asn Val Leu Val Leu Val Ile Leu Glu Arg His Arg 
65                  70                  75                  80  


Gln Thr Arg Ser Ser Thr Glu Thr Phe Leu Phe His Leu Ala Val Ala 
                85                  90                  95      


Asp Leu Leu Leu Val Phe Ile Leu Pro Phe Ala Val Ala Glu Gly Ser 
            100                 105                 110         


Val Gly Trp Val Leu Gly Thr Phe Leu Cys Lys Thr Val Ile Ala Leu 
        115                 120                 125             


His Lys Val Asn Phe Tyr Cys Ser Ser Leu Leu Leu Ala Cys Ile Ala 
    130                 135                 140                 


Val Asp Arg Tyr Leu Ala Ile Val His Ala Val His Ala Tyr Arg His 
145                 150                 155                 160 


Arg Arg Leu Leu Ser Ile His Ile Thr Cys Gly Thr Ile Trp Leu Val 
                165                 170                 175     


Gly Phe Leu Leu Ala Leu Pro Glu Ile Leu Phe Ala Lys Val Ser Gln 
            180                 185                 190         


Gly His His Asn Asn Ser Leu Pro Arg Cys Thr Phe Ser Gln Glu Asn 
        195                 200                 205             


Gln Ala Glu Thr His Ala Trp Phe Thr Ser Arg Phe Leu Tyr His Val 
    210                 215                 220                 


Ala Gly Phe Leu Leu Pro Met Leu Val Met Gly Trp Cys Tyr Val Gly 
225                 230                 235                 240 


Val Val His Arg Leu Arg Gln Ala Gln Arg Arg Pro Gln Arg Gln Lys 
                245                 250                 255     


Ala Val Arg Val Ala Ile Leu Val Thr Ser Ile Phe Phe Leu Cys Trp 
            260                 265                 270         


Ser Pro Tyr His Ile Val Ile Phe Leu Asp Thr Leu Ala Arg Leu Lys 
        275                 280                 285             


Ala Val Asp Asn Thr Cys Lys Leu Asn Gly Ser Leu Pro Val Ala Ile 
    290                 295                 300                 


Thr Met Cys Glu Phe Leu Gly Leu Ala His Cys Cys Leu Asn Pro Met 
305                 310                 315                 320 


Leu Tyr Thr Phe Ala Gly Val Lys Phe Arg Ser Asp Leu Ser Arg Leu 
                325                 330                 335     


Leu Thr Lys Leu Gly Cys Thr Gly Pro Ala Ser Leu Cys Gln Leu Phe 
            340                 345                 350         


Pro Ser Trp Arg Arg Ser Ser Leu Ser Glu Ser Glu Asn Ala Thr Ser 
        355                 360                 365             


Leu Thr Thr Phe 
    370         


<210>  637
<211>  327
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic amino acid

<400>  637

Met Ala Ser Phe Lys Ala Val Phe Val Pro Val Ala Tyr Ser Leu Ile 
1               5                   10                  15      


Phe Leu Leu Gly Val Ile Gly Asn Val Leu Val Leu Val Ile Leu Glu 
            20                  25                  30          


Arg His Arg Gln Thr Arg Ser Ser Thr Glu Thr Phe Leu Phe His Leu 
        35                  40                  45              


Ala Val Ala Asp Leu Leu Leu Val Phe Ile Leu Pro Phe Ala Val Ala 
    50                  55                  60                  


Glu Gly Ser Val Gly Trp Val Leu Gly Thr Phe Leu Cys Lys Thr Val 
65                  70                  75                  80  


Ile Ala Leu His Lys Val Asn Phe Tyr Cys Ser Ser Leu Leu Leu Ala 
                85                  90                  95      


Cys Ile Ala Val Asp Arg Tyr Leu Ala Ile Val His Ala Val His Ala 
            100                 105                 110         


Tyr Arg His Arg Arg Leu Leu Ser Ile His Ile Thr Cys Gly Thr Ile 
        115                 120                 125             


Trp Leu Val Gly Phe Leu Leu Ala Leu Pro Glu Ile Leu Phe Ala Lys 
    130                 135                 140                 


Val Ser Gln Gly His His Asn Asn Ser Leu Pro Arg Cys Thr Phe Ser 
145                 150                 155                 160 


Gln Glu Asn Gln Ala Glu Thr His Ala Trp Phe Thr Ser Arg Phe Leu 
                165                 170                 175     


Tyr His Val Ala Gly Phe Leu Leu Pro Met Leu Val Met Gly Trp Cys 
            180                 185                 190         


Tyr Val Gly Val Val His Arg Leu Arg Gln Ala Gln Arg Arg Pro Gln 
        195                 200                 205             


Arg Gln Lys Ala Val Arg Val Ala Ile Leu Val Thr Ser Ile Phe Phe 
    210                 215                 220                 


Leu Cys Trp Ser Pro Tyr His Ile Val Ile Phe Leu Asp Thr Leu Ala 
225                 230                 235                 240 


Arg Leu Lys Ala Val Asp Asn Thr Cys Lys Leu Asn Gly Ser Leu Pro 
                245                 250                 255     


Val Ala Ile Thr Met Cys Glu Phe Leu Gly Leu Ala His Cys Cys Leu 
            260                 265                 270         


Asn Pro Met Leu Tyr Thr Phe Ala Gly Val Lys Phe Arg Ser Asp Leu 
        275                 280                 285             


Ser Arg Leu Leu Thr Lys Leu Gly Cys Thr Gly Pro Ala Ser Leu Cys 
    290                 295                 300                 


Gln Leu Phe Pro Ser Trp Arg Arg Ser Ser Leu Ser Glu Ser Glu Asn 
305                 310                 315                 320 


Ala Thr Ser Leu Thr Thr Phe 
                325         


<210>  638
<211>  374
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic amino acid

<400>  638

Met Leu Ser Thr Ser Arg Ser Arg Phe Ile Arg Asn Thr Asn Glu Ser 
1               5                   10                  15      


Gly Glu Glu Val Thr Thr Phe Phe Asp Tyr Asp Tyr Gly Ala Pro Cys 
            20                  25                  30          


His Lys Phe Asp Val Lys Gln Ile Gly Ala Gln Leu Leu Pro Pro Leu 
        35                  40                  45              


Tyr Ser Leu Val Phe Ile Phe Gly Phe Val Gly Asn Met Leu Val Val 
    50                  55                  60                  


Leu Ile Leu Ile Asn Cys Lys Lys Leu Lys Cys Leu Thr Asp Ile Tyr 
65                  70                  75                  80  


Leu Leu Asn Leu Ala Ile Ser Asp Leu Leu Phe Leu Ile Thr Leu Pro 
                85                  90                  95      


Leu Trp Ala His Ser Ala Ala Asn Glu Trp Val Phe Gly Asn Ala Met 
            100                 105                 110         


Cys Lys Leu Phe Thr Gly Leu Tyr His Ile Gly Tyr Phe Gly Gly Ile 
        115                 120                 125             


Phe Phe Ile Ile Leu Leu Thr Ile Asp Arg Tyr Leu Ala Ile Val His 
    130                 135                 140                 


Ala Val Phe Ala Leu Lys Ala Arg Thr Val Thr Phe Gly Val Val Thr 
145                 150                 155                 160 


Ser Val Ile Thr Trp Leu Val Ala Val Phe Ala Ser Val Pro Gly Ile 
                165                 170                 175     


Ile Phe Thr Lys Cys Gln Lys Glu Asp Ser Val Tyr Val Cys Gly Pro 
            180                 185                 190         


Tyr Phe Pro Arg Gly Trp Asn Asn Phe His Thr Ile Met Arg Asn Ile 
        195                 200                 205             


Leu Gly Leu Val Leu Pro Leu Leu Ile Met Val Ile Cys Tyr Ser Gly 
    210                 215                 220                 


Ile Leu Lys Thr Leu Leu Arg Cys Arg Asn Glu Lys Lys Arg His Arg 
225                 230                 235                 240 


Ala Val Arg Val Ile Phe Thr Ile Met Ile Val Tyr Phe Leu Phe Trp 
                245                 250                 255     


Thr Pro Tyr Asn Ile Val Ile Leu Leu Asn Thr Phe Gln Glu Phe Phe 
            260                 265                 270         


Gly Leu Ser Asn Cys Glu Ser Thr Ser Gln Leu Asp Gln Ala Thr Gln 
        275                 280                 285             


Val Thr Glu Thr Leu Gly Met Thr His Cys Cys Ile Asn Pro Ile Ile 
    290                 295                 300                 


Tyr Ala Phe Val Gly Glu Lys Phe Arg Ser Leu Phe His Ile Ala Leu 
305                 310                 315                 320 


Gly Cys Arg Ile Ala Pro Leu Gln Lys Pro Val Cys Gly Gly Pro Gly 
                325                 330                 335     


Val Arg Pro Gly Lys Asn Val Lys Val Thr Thr Gln Gly Leu Leu Asp 
            340                 345                 350         


Gly Arg Gly Lys Gly Lys Ser Ile Gly Arg Ala Pro Glu Ala Ser Leu 
        355                 360                 365             


Gln Asp Lys Glu Gly Ala 
    370                 


<210>  639
<211>  360
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic amino acid

<400>  639

Met Leu Ser Thr Ser Arg Ser Arg Phe Ile Arg Asn Thr Asn Glu Ser 
1               5                   10                  15      


Gly Glu Glu Val Thr Thr Phe Phe Asp Tyr Asp Tyr Gly Ala Pro Cys 
            20                  25                  30          


His Lys Phe Asp Val Lys Gln Ile Gly Ala Gln Leu Leu Pro Pro Leu 
        35                  40                  45              


Tyr Ser Leu Val Phe Ile Phe Gly Phe Val Gly Asn Met Leu Val Val 
    50                  55                  60                  


Leu Ile Leu Ile Asn Cys Lys Lys Leu Lys Cys Leu Thr Asp Ile Tyr 
65                  70                  75                  80  


Leu Leu Asn Leu Ala Ile Ser Asp Leu Leu Phe Leu Ile Thr Leu Pro 
                85                  90                  95      


Leu Trp Ala His Ser Ala Ala Asn Glu Trp Val Phe Gly Asn Ala Met 
            100                 105                 110         


Cys Lys Leu Phe Thr Gly Leu Tyr His Ile Gly Tyr Phe Gly Gly Ile 
        115                 120                 125             


Phe Phe Ile Ile Leu Leu Thr Ile Asp Arg Tyr Leu Ala Ile Val His 
    130                 135                 140                 


Ala Val Phe Ala Leu Lys Ala Arg Thr Val Thr Phe Gly Val Val Thr 
145                 150                 155                 160 


Ser Val Ile Thr Trp Leu Val Ala Val Phe Ala Ser Val Pro Gly Ile 
                165                 170                 175     


Ile Phe Thr Lys Cys Gln Lys Glu Asp Ser Val Tyr Val Cys Gly Pro 
            180                 185                 190         


Tyr Phe Pro Arg Gly Trp Asn Asn Phe His Thr Ile Met Arg Asn Ile 
        195                 200                 205             


Leu Gly Leu Val Leu Pro Leu Leu Ile Met Val Ile Cys Tyr Ser Gly 
    210                 215                 220                 


Ile Leu Lys Thr Leu Leu Arg Cys Arg Asn Glu Lys Lys Arg His Arg 
225                 230                 235                 240 


Ala Val Arg Val Ile Phe Thr Ile Met Ile Val Tyr Phe Leu Phe Trp 
                245                 250                 255     


Thr Pro Tyr Asn Ile Val Ile Leu Leu Asn Thr Phe Gln Glu Phe Phe 
            260                 265                 270         


Gly Leu Ser Asn Cys Glu Ser Thr Ser Gln Leu Asp Gln Ala Thr Gln 
        275                 280                 285             


Val Thr Glu Thr Leu Gly Met Thr His Cys Cys Ile Asn Pro Ile Ile 
    290                 295                 300                 


Tyr Ala Phe Val Gly Glu Lys Phe Arg Arg Tyr Leu Ser Val Phe Phe 
305                 310                 315                 320 


Arg Lys His Ile Thr Lys Arg Phe Cys Lys Gln Cys Pro Val Phe Tyr 
                325                 330                 335     


Arg Glu Thr Val Asp Gly Val Thr Ser Thr Asn Thr Pro Ser Thr Gly 
            340                 345                 350         


Glu Gln Glu Val Ser Ala Gly Leu 
        355                 360 


<210>  640
<211>  360
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic amino acid

<400>  640

Met Asn Pro Thr Asp Ile Ala Asp Thr Thr Leu Asp Glu Ser Ile Tyr 
1               5                   10                  15      


Ser Asn Tyr Tyr Leu Tyr Glu Ser Ile Pro Lys Pro Cys Thr Lys Glu 
            20                  25                  30          


Gly Ile Lys Ala Phe Gly Glu Leu Phe Leu Pro Pro Leu Tyr Ser Leu 
        35                  40                  45              


Val Phe Val Phe Gly Leu Leu Gly Asn Ser Val Val Val Leu Val Leu 
    50                  55                  60                  


Phe Lys Tyr Lys Arg Leu Arg Ser Met Thr Asp Val Tyr Leu Leu Asn 
65                  70                  75                  80  


Leu Ala Ile Ser Asp Leu Leu Phe Val Phe Ser Leu Pro Phe Trp Gly 
                85                  90                  95      


Tyr Tyr Ala Ala Asp Gln Trp Val Phe Gly Leu Gly Leu Cys Lys Met 
            100                 105                 110         


Ile Ser Trp Met Tyr Leu Val Gly Phe Tyr Ser Gly Ile Phe Phe Val 
        115                 120                 125             


Met Leu Met Ser Ile Asp Arg Tyr Leu Ala Ile Val His Ala Val Phe 
    130                 135                 140                 


Ser Leu Arg Ala Arg Thr Leu Thr Tyr Gly Val Ile Thr Ser Leu Ala 
145                 150                 155                 160 


Thr Trp Ser Val Ala Val Phe Ala Ser Leu Pro Gly Phe Leu Phe Ser 
                165                 170                 175     


Thr Cys Tyr Thr Glu Arg Asn His Thr Tyr Cys Lys Thr Lys Tyr Ser 
            180                 185                 190         


Leu Asn Ser Thr Thr Trp Lys Val Leu Ser Ser Leu Glu Ile Asn Ile 
        195                 200                 205             


Leu Gly Leu Val Ile Pro Leu Gly Ile Met Leu Phe Cys Tyr Ser Met 
    210                 215                 220                 


Ile Ile Arg Thr Leu Gln His Cys Lys Asn Glu Lys Lys Asn Lys Ala 
225                 230                 235                 240 


Val Lys Met Ile Phe Ala Val Val Val Leu Phe Leu Gly Phe Trp Thr 
                245                 250                 255     


Pro Tyr Asn Ile Val Leu Phe Leu Glu Thr Leu Val Glu Leu Glu Val 
            260                 265                 270         


Leu Gln Asp Cys Thr Phe Glu Arg Tyr Leu Asp Tyr Ala Ile Gln Ala 
        275                 280                 285             


Thr Glu Thr Leu Ala Phe Val His Cys Cys Leu Asn Pro Ile Ile Tyr 
    290                 295                 300                 


Phe Phe Leu Gly Glu Lys Phe Arg Lys Tyr Ile Leu Gln Leu Phe Lys 
305                 310                 315                 320 


Thr Cys Arg Gly Leu Phe Val Leu Cys Gln Tyr Cys Gly Leu Leu Gln 
                325                 330                 335     


Ile Tyr Ser Ala Asp Thr Pro Ser Ser Ser Tyr Thr Gln Ser Thr Met 
            340                 345                 350         


Asp His Asp Leu His Asp Ala Leu 
        355                 360 


<210>  641
<211>  374
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic amino acid

<400>  641

Met Ser Gly Glu Ser Met Asn Phe Ser Asp Val Phe Asp Ser Ser Glu 
1               5                   10                  15      


Asp Tyr Phe Val Ser Val Asn Thr Ser Tyr Tyr Ser Val Asp Ser Glu 
            20                  25                  30          


Met Leu Leu Cys Ser Leu Gln Glu Val Arg Gln Phe Ser Arg Leu Phe 
        35                  40                  45              


Val Pro Ile Ala Tyr Ser Leu Ile Cys Val Phe Gly Leu Leu Gly Asn 
    50                  55                  60                  


Ile Leu Val Val Ile Thr Phe Ala Phe Tyr Lys Lys Ala Arg Ser Met 
65                  70                  75                  80  


Thr Asp Val Tyr Leu Leu Asn Met Ala Ile Ala Asp Ile Leu Phe Val 
                85                  90                  95      


Leu Thr Leu Pro Phe Trp Ala Val Ser His Ala Thr Gly Ala Trp Val 
            100                 105                 110         


Phe Ser Asn Ala Thr Cys Lys Leu Leu Lys Gly Ile Tyr Ala Ile Asn 
        115                 120                 125             


Phe Asn Cys Gly Met Leu Leu Leu Thr Cys Ile Ser Met Asp Arg Tyr 
    130                 135                 140                 


Ile Ala Ile Val Gln Ala Thr Lys Ser Phe Arg Leu Arg Ser Arg Thr 
145                 150                 155                 160 


Leu Pro Arg Ser Lys Ile Ile Cys Leu Val Val Trp Gly Leu Ser Val 
                165                 170                 175     


Ile Ile Ser Ser Ser Thr Phe Val Phe Asn Gln Lys Tyr Asn Thr Gln 
            180                 185                 190         


Gly Ser Asp Val Cys Glu Pro Lys Tyr Gln Thr Val Ser Glu Pro Ile 
        195                 200                 205             


Arg Trp Lys Leu Leu Met Leu Gly Leu Glu Leu Leu Phe Gly Phe Phe 
    210                 215                 220                 


Ile Pro Leu Met Phe Met Ile Phe Cys Tyr Thr Phe Ile Val Lys Thr 
225                 230                 235                 240 


Leu Val Gln Ala Gln Asn Ser Lys Arg His Lys Ala Ile Arg Val Ile 
                245                 250                 255     


Ile Ala Val Val Leu Val Phe Leu Ala Cys Gln Ile Pro His Asn Met 
            260                 265                 270         


Val Leu Leu Val Thr Ala Ala Asn Leu Gly Lys Met Asn Arg Ser Cys 
        275                 280                 285             


Gln Ser Glu Lys Leu Ile Gly Tyr Thr Lys Thr Val Thr Glu Val Leu 
    290                 295                 300                 


Ala Phe Leu His Cys Cys Leu Asn Pro Val Leu Tyr Ala Phe Ile Gly 
305                 310                 315                 320 


Gln Lys Phe Arg Asn Tyr Phe Leu Lys Ile Leu Lys Asp Leu Trp Cys 
                325                 330                 335     


Val Arg Arg Lys Tyr Lys Ser Ser Gly Phe Ser Cys Ala Gly Arg Tyr 
            340                 345                 350         


Ser Glu Asn Ile Ser Arg Gln Thr Ser Glu Thr Ala Asp Asn Asp Asn 
        355                 360                 365             


Ala Ser Ser Phe Thr Met 
    370                 


<210>  642
<211>  378
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic amino acid

<400>  642

Met Asp Leu Gly Lys Pro Met Lys Ser Val Leu Val Val Ala Leu Leu 
1               5                   10                  15      


Val Ile Phe Gln Val Cys Leu Cys Gln Asp Glu Val Thr Asp Asp Tyr 
            20                  25                  30          


Ile Gly Asp Asn Thr Thr Val Asp Tyr Thr Leu Phe Glu Ser Leu Cys 
        35                  40                  45              


Ser Lys Lys Asp Val Arg Asn Phe Lys Ala Trp Phe Leu Pro Ile Met 
    50                  55                  60                  


Tyr Ser Ile Ile Cys Phe Val Gly Leu Leu Gly Asn Gly Leu Val Val 
65                  70                  75                  80  


Leu Thr Tyr Ile Tyr Phe Lys Arg Leu Lys Thr Met Thr Asp Thr Tyr 
                85                  90                  95      


Leu Leu Asn Leu Ala Val Ala Asp Ile Leu Phe Leu Leu Thr Leu Pro 
            100                 105                 110         


Phe Trp Ala Tyr Ser Ala Ala Lys Ser Trp Val Phe Gly Val His Phe 
        115                 120                 125             


Cys Lys Leu Ile Phe Ala Ile Tyr Lys Met Ser Phe Phe Ser Gly Met 
    130                 135                 140                 


Leu Leu Leu Leu Cys Ile Ser Ile Asp Arg Tyr Val Ala Ile Val Gln 
145                 150                 155                 160 


Ala Val Ser Ala His Arg His Arg Ala Arg Val Leu Leu Ile Ser Lys 
                165                 170                 175     


Leu Ser Cys Val Gly Ile Trp Ile Leu Ala Thr Val Leu Ser Ile Pro 
            180                 185                 190         


Glu Leu Leu Tyr Ser Asp Leu Gln Arg Ser Ser Ser Glu Gln Ala Met 
        195                 200                 205             


Arg Cys Ser Leu Ile Thr Glu His Val Glu Ala Phe Ile Thr Ile Gln 
    210                 215                 220                 


Val Ala Gln Met Val Ile Gly Phe Leu Val Pro Leu Leu Ala Met Ser 
225                 230                 235                 240 


Phe Cys Tyr Leu Val Ile Ile Arg Thr Leu Leu Gln Ala Arg Asn Phe 
                245                 250                 255     


Glu Arg Asn Lys Ala Ile Lys Val Ile Ile Ala Val Val Val Val Phe 
            260                 265                 270         


Ile Val Phe Gln Leu Pro Tyr Asn Gly Val Val Leu Ala Gln Thr Val 
        275                 280                 285             


Ala Asn Phe Asn Ile Thr Ser Ser Thr Cys Glu Leu Ser Lys Gln Leu 
    290                 295                 300                 


Asn Ile Ala Tyr Asp Val Thr Tyr Ser Leu Ala Cys Val Arg Cys Cys 
305                 310                 315                 320 


Val Asn Pro Phe Leu Tyr Ala Phe Ile Gly Val Lys Phe Arg Asn Asp 
                325                 330                 335     


Leu Phe Lys Leu Phe Lys Asp Leu Gly Cys Leu Ser Gln Glu Gln Leu 
            340                 345                 350         


Arg Gln Trp Ser Ser Cys Arg His Ile Arg Arg Ser Ser Met Ser Val 
        355                 360                 365             


Glu Ala Glu Thr Thr Thr Thr Phe Ser Pro 
    370                 375             


<210>  643
<211>  315
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic amino acid

<400>  643

Met Tyr Ser Ile Ile Cys Phe Val Gly Leu Leu Gly Asn Gly Leu Val 
1               5                   10                  15      


Val Leu Thr Tyr Ile Tyr Phe Lys Arg Leu Lys Thr Met Thr Asp Thr 
            20                  25                  30          


Tyr Leu Leu Asn Leu Ala Val Ala Asp Ile Leu Phe Leu Leu Thr Leu 
        35                  40                  45              


Pro Phe Trp Ala Tyr Ser Ala Ala Lys Ser Trp Val Phe Gly Val His 
    50                  55                  60                  


Phe Cys Lys Leu Ile Phe Ala Ile Tyr Lys Met Ser Phe Phe Ser Gly 
65                  70                  75                  80  


Met Leu Leu Leu Leu Cys Ile Ser Ile Asp Arg Tyr Val Ala Ile Val 
                85                  90                  95      


Gln Ala Val Ser Ala His Arg His Arg Ala Arg Val Leu Leu Ile Ser 
            100                 105                 110         


Lys Leu Ser Cys Val Gly Ile Trp Ile Leu Ala Thr Val Leu Ser Ile 
        115                 120                 125             


Pro Glu Leu Leu Tyr Ser Asp Leu Gln Arg Ser Ser Ser Glu Gln Ala 
    130                 135                 140                 


Met Arg Cys Ser Leu Ile Thr Glu His Val Glu Ala Phe Ile Thr Ile 
145                 150                 155                 160 


Gln Val Ala Gln Met Val Ile Gly Phe Leu Val Pro Leu Leu Ala Met 
                165                 170                 175     


Ser Phe Cys Tyr Leu Val Ile Ile Arg Thr Leu Leu Gln Ala Arg Asn 
            180                 185                 190         


Phe Glu Arg Asn Lys Ala Ile Lys Val Ile Ile Ala Val Val Val Val 
        195                 200                 205             


Phe Ile Val Phe Gln Leu Pro Tyr Asn Gly Val Val Leu Ala Gln Thr 
    210                 215                 220                 


Val Ala Asn Phe Asn Ile Thr Ser Ser Thr Cys Glu Leu Ser Lys Gln 
225                 230                 235                 240 


Leu Asn Ile Ala Tyr Asp Val Thr Tyr Ser Leu Ala Cys Val Arg Cys 
                245                 250                 255     


Cys Val Asn Pro Phe Leu Tyr Ala Phe Ile Gly Val Lys Phe Arg Asn 
            260                 265                 270         


Asp Leu Phe Lys Leu Phe Lys Asp Leu Gly Cys Leu Ser Gln Glu Gln 
        275                 280                 285             


Leu Arg Gln Trp Ser Ser Cys Arg His Ile Arg Arg Ser Ser Met Ser 
    290                 295                 300                 


Val Glu Ala Glu Thr Thr Thr Thr Phe Ser Pro 
305                 310                 315 


<210>  644
<211>  372
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic amino acid

<400>  644

Met Lys Ser Val Leu Val Val Ala Leu Leu Val Ile Phe Gln Val Cys 
1               5                   10                  15      


Leu Cys Gln Asp Glu Val Thr Asp Asp Tyr Ile Gly Asp Asn Thr Thr 
            20                  25                  30          


Val Asp Tyr Thr Leu Phe Glu Ser Leu Cys Ser Lys Lys Asp Val Arg 
        35                  40                  45              


Asn Phe Lys Ala Trp Phe Leu Pro Ile Met Tyr Ser Ile Ile Cys Phe 
    50                  55                  60                  


Val Gly Leu Leu Gly Asn Gly Leu Val Val Leu Thr Tyr Ile Tyr Phe 
65                  70                  75                  80  


Lys Arg Leu Lys Thr Met Thr Asp Thr Tyr Leu Leu Asn Leu Ala Val 
                85                  90                  95      


Ala Asp Ile Leu Phe Leu Leu Thr Leu Pro Phe Trp Ala Tyr Ser Ala 
            100                 105                 110         


Ala Lys Ser Trp Val Phe Gly Val His Phe Cys Lys Leu Ile Phe Ala 
        115                 120                 125             


Ile Tyr Lys Met Ser Phe Phe Ser Gly Met Leu Leu Leu Leu Cys Ile 
    130                 135                 140                 


Ser Ile Asp Arg Tyr Val Ala Ile Val Gln Ala Val Ser Ala His Arg 
145                 150                 155                 160 


His Arg Ala Arg Val Leu Leu Ile Ser Lys Leu Ser Cys Val Gly Ile 
                165                 170                 175     


Trp Ile Leu Ala Thr Val Leu Ser Ile Pro Glu Leu Leu Tyr Ser Asp 
            180                 185                 190         


Leu Gln Arg Ser Ser Ser Glu Gln Ala Met Arg Cys Ser Leu Ile Thr 
        195                 200                 205             


Glu His Val Glu Ala Phe Ile Thr Ile Gln Val Ala Gln Met Val Ile 
    210                 215                 220                 


Gly Phe Leu Val Pro Leu Leu Ala Met Ser Phe Cys Tyr Leu Val Ile 
225                 230                 235                 240 


Ile Arg Thr Leu Leu Gln Ala Arg Asn Phe Glu Arg Asn Lys Ala Ile 
                245                 250                 255     


Lys Val Ile Ile Ala Val Val Val Val Phe Ile Val Phe Gln Leu Pro 
            260                 265                 270         


Tyr Asn Gly Val Val Leu Ala Gln Thr Val Ala Asn Phe Asn Ile Thr 
        275                 280                 285             


Ser Ser Thr Cys Glu Leu Ser Lys Gln Leu Asn Ile Ala Tyr Asp Val 
    290                 295                 300                 


Thr Tyr Ser Leu Ala Cys Val Arg Cys Cys Val Asn Pro Phe Leu Tyr 
305                 310                 315                 320 


Ala Phe Ile Gly Val Lys Phe Arg Asn Asp Leu Phe Lys Leu Phe Lys 
                325                 330                 335     


Asp Leu Gly Cys Leu Ser Gln Glu Gln Leu Arg Gln Trp Ser Ser Cys 
            340                 345                 350         


Arg His Ile Arg Arg Ser Ser Met Ser Val Glu Ala Glu Thr Thr Thr 
        355                 360                 365             


Thr Phe Ser Pro 
    370         


<210>  645
<211>  355
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic amino acid

<400>  645

Met Asp Tyr Thr Leu Asp Leu Ser Val Thr Thr Val Thr Asp Tyr Tyr 
1               5                   10                  15      


Tyr Pro Asp Ile Phe Ser Ser Pro Cys Asp Ala Glu Leu Ile Gln Thr 
            20                  25                  30          


Asn Gly Lys Leu Leu Leu Ala Val Phe Tyr Cys Leu Leu Phe Val Phe 
        35                  40                  45              


Ser Leu Leu Gly Asn Ser Leu Val Ile Leu Val Leu Val Val Cys Lys 
    50                  55                  60                  


Lys Leu Arg Ser Ile Thr Asp Val Tyr Leu Leu Asn Leu Ala Leu Ser 
65                  70                  75                  80  


Asp Leu Leu Phe Val Phe Ser Phe Pro Phe Gln Thr Tyr Tyr Leu Leu 
                85                  90                  95      


Asp Gln Trp Val Phe Gly Thr Val Met Cys Lys Val Val Ser Gly Phe 
            100                 105                 110         


Tyr Tyr Ile Gly Phe Tyr Ser Ser Met Phe Phe Ile Thr Leu Met Ser 
        115                 120                 125             


Val Asp Arg Tyr Leu Ala Val Val His Ala Val Tyr Ala Leu Lys Val 
    130                 135                 140                 


Arg Thr Ile Arg Met Gly Thr Thr Leu Cys Leu Ala Val Trp Leu Thr 
145                 150                 155                 160 


Ala Ile Met Ala Thr Ile Pro Leu Leu Val Phe Tyr Gln Val Ala Ser 
                165                 170                 175     


Glu Asp Gly Val Leu Gln Cys Tyr Ser Phe Tyr Asn Gln Gln Thr Leu 
            180                 185                 190         


Lys Trp Lys Ile Phe Thr Asn Phe Lys Met Asn Ile Leu Gly Leu Leu 
        195                 200                 205             


Ile Pro Phe Thr Ile Phe Met Phe Cys Tyr Ile Lys Ile Leu His Gln 
    210                 215                 220                 


Leu Lys Arg Cys Gln Asn His Asn Lys Thr Lys Ala Ile Arg Leu Val 
225                 230                 235                 240 


Leu Ile Val Val Ile Ala Ser Leu Leu Phe Trp Val Pro Phe Asn Val 
                245                 250                 255     


Val Leu Phe Leu Thr Ser Leu His Ser Met His Ile Leu Asp Gly Cys 
            260                 265                 270         


Ser Ile Ser Gln Gln Leu Thr Tyr Ala Thr His Val Thr Glu Ile Ile 
        275                 280                 285             


Ser Phe Thr His Cys Cys Val Asn Pro Val Ile Tyr Ala Phe Val Gly 
    290                 295                 300                 


Glu Lys Phe Lys Lys His Leu Ser Glu Ile Phe Gln Lys Ser Cys Ser 
305                 310                 315                 320 


Gln Ile Phe Asn Tyr Leu Gly Arg Gln Met Pro Arg Glu Ser Cys Glu 
                325                 330                 335     


Lys Ser Ser Ser Cys Gln Gln His Ser Ser Arg Ser Ser Ser Val Asp 
            340                 345                 350         


Tyr Ile Leu 
        355 


<210>  646
<211>  2459
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Synthetic nucleotide

<400>  646
actctgatct ctgactgcag ctcctactgt tggacacacc tggccggtgc ttcagttaga       60

tcaaaccatt gctgaaactg aagaggacat gtcaaatatt acagatccac agatgtggga      120

ttttgatgat ctaaatttca ctggcatgcc acctgcagat gaagattaca gcccctgtat      180

gctagaaact gagacactca acaagtatgt tgtgatcatc gcctatgccc tagtgttcct      240

gctgagcctg ctgggaaact ccctggtgat gctggtcatc ttatacagca gggtcggccg      300

ctccgtcact gatgtctacc tgctgaacct ggccttggcc gacctactct ttgccctgac      360

cttgcccatc tgggccgcct ccaaggtgaa tggctggatt tttggcacat tcctgtgcaa      420

ggtggtctca ctcctgaagg aagtcaactt ctacagtggc atcctgctgt tggcctgcat      480

cagtgtggac cgttacctgg ccattgtcca tgccacacgc acactgaccc agaagcgtca      540

cttggtcaag tttgtttgtc ttggctgctg gggactgtct atgaatctgt ccctgccctt      600

cttccttttc cgccaggctt accatccaaa caattccagt ccagtttgct atgaggtcct      660

gggaaatgac acagcaaaat ggcggatggt gttgcggatc ctgcctcaca cctttggctt      720

catcgtgccg ctgtttgtca tgctgttctg ctatggattc accctgcgta cactgtttaa      780

ggcccacatg gggcagaagc accgagccat gagggtcatc tttgctgtcg tcctcatctt      840

cctgctttgc tggctgccct acaacctggt cctgctggca gacaccctca tgaggaccca      900

ggtgatccag gagagctgtg agcgccgcaa caacatcggc cgggccctgg atgccactga      960

gattctggga tttctccata gctgcctcaa ccccatcatc tacgccttca tcggccaaaa     1020

ttttcgccat ggattcctca agatcctggc tatgcatggc ctggtcagca aggagttctt     1080

ggcacgtcat cgtgttacct cctacacttc ttcgtctgtc aatgtctctt ccaacctctg     1140

aaaaccatcg atgaaggaat atctcttctc agaaggaaag aataaccaac accctgaggt     1200

tgtgtgtgga aggtgatctg gctctggaca ggcactatct gggttttggg gggacgctat     1260

aggatgtggg gaagttagga actggtgtct tcaggggcca caccaacctt ctgaggagct     1320

gttgaggtac ctccaaggac cggcctttgc acctccatgg aaacgaagca ccatcattcc     1380

cgttgaacgt cacatcttta acccactaac tggctaatta gcatggccac atctgagccc     1440

cgaatctgac attagatgag agaacagggc tgaagctgtg tcctcatgag ggctggatgc     1500

tctcgttgac cctcacagga gcatctcctc aactctgagt gttaagcgtt gagccaccaa     1560

gctggtggct ctgtgtgctc tgatccgagc tcaggggggt ggttttccca tctcaggtgt     1620

gttgcagtgt ctgctggaga cattgaggca ggcactgcca aaacatcaac ctgccagctg     1680

gccttgtgag gagctggaaa cacatgttcc ccttgggggt ggtggatgaa caaagagaaa     1740

gagggtttgg aagccagatc tatgccacaa gaaccccctt tacccccatg accaacatcg     1800

cagacacatg tgctggccac ctgctgagcc ccaagtggaa cgagacaagc agcccttagc     1860

ccttcccctc tgcagcttcc aggctggcgt gcagcatcag catccctaga aagccatgtg     1920

cagccaccag tccattgggc aggcagatgt tcctaataaa gcttctgttc cgtgcttgtc     1980

cctgtggaag tatcttggtt gtgacagagt caagggtgtg tgcagcattg ttggctgttc     2040

ctgcagtaga atgggggcag cacctcctaa gaaggcacct ctctgggttg aagggcagtg     2100

ttccctgggg ctttaactcc tgctagaaca gtctcttgag gcacagaaac tcctgttcat     2160

gcccataccc ctggccaagg aagatccctt tgtccacaag taaaaggaaa tgctcctcca     2220

gggagtctca gcttcaccct gaggtgagca tcatcttctg ggttaggcct tgcctaggca     2280

tagccctgcc tcaagctatg tgagctcacc agtccctccc caaatgcttt ccatgagttg     2340

cagttttttc ctagtctgtt ttccctcctt ggagacaggg ccctgtcggt ttattcactg     2400

tatgtccttg gtgcctggag cctactaaat gctcaataaa taatgatcac aggaatgaa      2459


<210>  647
<211>  2853
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Synthetic nucleotide

<400>  647
agagacagaa ggtggataga caaatctcca ccttcagact ggtaggctcc tccagaagcc       60

atcagacagg aagatgtgaa aatccccagc actcatccca gaatcactaa gtggcacctg      120

tcctgggcca aagtcccagg acagacctca ttgttcctct gtgggaatac ctccccagga      180

gggcatcctg gatttccccc ttgcaaccca ggtcagaagt ttcatcgtca aggttgtttc      240

atcttttttt tcctgtctaa cagctctgac taccacccaa ccttgaggca cagtgaagac      300

atcggtggcc actccaataa cagcaggtca cagctgctct tctggaggtg tcctacaggt      360

gaaaagccca gcgacccagt caggatttaa gtttacctca aaaatggaag attttaacat      420

ggagagtgac agctttgaag atttctggaa aggtgaagat cttagtaatt acagttacag      480

ctctaccctg cccccttttc tactagatgc cgccccatgt gaaccagaat ccctggaaat      540

caacaagtat tttgtggtca ttatctatgc cctggtattc ctgctgagcc tgctgggaaa      600

ctccctcgtg atgctggtca tcttatacag cagggtcggc cgctccgtca ctgatgtcta      660

cctgctgaac ctagccttgg ccgacctact ctttgccctg accttgccca tctgggccgc      720

ctccaaggtg aatggctgga tttttggcac attcctgtgc aaggtggtct cactcctgaa      780

ggaagtcaac ttctatagtg gcatcctgct actggcctgc atcagtgtgg accgttacct      840

ggccattgtc catgccacac gcacactgac ccagaagcgc tacttggtca aattcatatg      900

tctcagcatc tggggtctgt ccttgctcct ggccctgcct gtcttacttt tccgaaggac      960

cgtctactca tccaatgtta gcccagcctg ctatgaggac atgggcaaca atacagcaaa     1020

ctggcggatg ctgttacgga tcctgcccca gtcctttggc ttcatcgtgc cactgctgat     1080

catgctgttc tgctacggat tcaccctgcg tacgctgttt aaggcccaca tggggcagaa     1140

gcaccgggcc atgcgggtca tctttgctgt cgtcctcatc ttcctgctct gctggctgcc     1200

ctacaacctg gtcctgctgg cagacaccct catgaggacc caggtgatcc aggagacctg     1260

tgagcgccgc aatcacatcg accgggctct ggatgccacc gagattctgg gcatccttca     1320

cagctgcctc aaccccctca tctacgcctt cattggccag aagtttcgcc atggactcct     1380

caagattcta gctatacatg gcttgatcag caaggactcc ctgcccaaag acagcaggcc     1440

ttcctttgtt ggctcttctt cagggcacac ttccactact ctctaagacc tcctgcctaa     1500

gtgcagcccc gtggggttcc tcccttctct tcacagtcac attccaagcc tcatgtccac     1560

tggttcttct tggtctcagt gtcaatgcag cccccattgt ggtcacagga agtagaggag     1620

gccacgttct tactagtttc ccttgcatgg tttagaaagc ttgccctggt gcctcacccc     1680

ttgccataat tactatgtca tttgctggag ctctgcccat cctgcccctg agcccatggc     1740

actctatgtt ctaagaagtg aaaatctaca ctccagtgag acagctctgc atactcatta     1800

ggatggctag tatcaaaaga aagaaaatca ggctggccaa cggggtgaaa ccctgtctct     1860

actaaaaata caaaaaaaaa aaaaaattag ccgggcgtgg tggtgagtgc ctgtaatcac     1920

agctacttgg gaggctgaga tgggagaatc acttgaaccc gggaggcaga ggttgcagtg     1980

agccgagatt gtgcccctgc actccagcct gagcgacagt gagactctgt ctcagtccat     2040

gaagatgtag aggagaaact ggaactctcg agcgttgctg ggggggattg taaaatggtg     2100

tgaccactgc agaagacagt atggcagctt tcctcaaaac ttcagacata gaattaacac     2160

atgatcctgc aattccactt ataggaattg acccacaaga aatgaaagca gggacttgaa     2220

cccatatttg tacaccaata ttcatagcag cttattcaca agacccaaaa ggcagaagca     2280

acccaaatgt tcatcaatga atgaatgaat ggctaagcaa aatgtgatat gtacctaacg     2340

aagtatcctt cagcctgaaa gaggaatgaa gtactcatac atgttacaac acggacgaac     2400

cttgaaaact ttatgctaag tgaaataagc cagacatcaa cagataaata gtttatgatt     2460

ccacctacat gaggtactga gagtgaacaa atttacagag acagaaagca gaacagtgat     2520

taccagggac tgaggggagg ggagcatggg aagtgacggt ttaatgggca cagggtttat     2580

gtttaggatg ttgaaaaagt tctgcagata aacagtagtg atagttgtac cgcaatgtga     2640

cttaatgcca ctaaattgac acttaaaaat ggtttaaatg gtcaattttg ttatgtatat     2700

tttatatcaa tttaaaaaaa aacctgagcc ccaaaaggta ttttaatcac caaggctgat     2760

taaaccaagg ctagaaccac ctgcctatat tttttgttaa atgatttcat tcaatatctt     2820

ttttttaata aaccattttt acttgggtgt tta                                  2853


<210>  648
<211>  2656
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Synthetic nucleotide

<400>  648
agtggtgata gctgagaata tgcagccgtt ttctccttcc tgggtacagt gctattctgc       60

ctagagctct gactaccacc caaccttgag gcacagtgaa gacatcggtg gccactccaa      120

taacagcagg tcacagctgc tcttctggag gtgtcctaca ggtgaaaagc ccagcgaccc      180

agtcaggatt taagtttacc tcaaaaatgg aagattttaa catggagagt gacagctttg      240

aagatttctg gaaaggtgaa gatcttagta attacagtta cagctctacc ctgccccctt      300

ttctactaga tgccgcccca tgtgaaccag aatccctgga aatcaacaag tattttgtgg      360

tcattatcta tgccctggta ttcctgctga gcctgctggg aaactccctc gtgatgctgg      420

tcatcttata cagcagggtc ggccgctccg tcactgatgt ctacctgctg aacctagcct      480

tggccgacct actctttgcc ctgaccttgc ccatctgggc cgcctccaag gtgaatggct      540

ggatttttgg cacattcctg tgcaaggtgg tctcactcct gaaggaagtc aacttctata      600

gtggcatcct gctactggcc tgcatcagtg tggaccgtta cctggccatt gtccatgcca      660

cacgcacact gacccagaag cgctacttgg tcaaattcat atgtctcagc atctggggtc      720

tgtccttgct cctggccctg cctgtcttac ttttccgaag gaccgtctac tcatccaatg      780

ttagcccagc ctgctatgag gacatgggca acaatacagc aaactggcgg atgctgttac      840

ggatcctgcc ccagtccttt ggcttcatcg tgccactgct gatcatgctg ttctgctacg      900

gattcaccct gcgtacgctg tttaaggccc acatggggca gaagcaccgg gccatgcggg      960

tcatctttgc tgtcgtcctc atcttcctgc tctgctggct gccctacaac ctggtcctgc     1020

tggcagacac cctcatgagg acccaggtga tccaggagac ctgtgagcgc cgcaatcaca     1080

tcgaccgggc tctggatgcc accgagattc tgggcatcct tcacagctgc ctcaaccccc     1140

tcatctacgc cttcattggc cagaagtttc gccatggact cctcaagatt ctagctatac     1200

atggcttgat cagcaaggac tccctgccca aagacagcag gccttccttt gttggctctt     1260

cttcagggca cacttccact actctctaag acctcctgcc taagtgcagc cccgtggggt     1320

tcctcccttc tcttcacagt cacattccaa gcctcatgtc cactggttct tcttggtctc     1380

agtgtcaatg cagcccccat tgtggtcaca ggaagtagag gaggccacgt tcttactagt     1440

ttcccttgca tggtttagaa agcttgccct ggtgcctcac cccttgccat aattactatg     1500

tcatttgctg gagctctgcc catcctgccc ctgagcccat ggcactctat gttctaagaa     1560

gtgaaaatct acactccagt gagacagctc tgcatactca ttaggatggc tagtatcaaa     1620

agaaagaaaa tcaggctggc caacggggtg aaaccctgtc tctactaaaa atacaaaaaa     1680

aaaaaaaaat tagccgggcg tggtggtgag tgcctgtaat cacagctact tgggaggctg     1740

agatgggaga atcacttgaa cccgggaggc agaggttgca gtgagccgag attgtgcccc     1800

tgcactccag cctgagcgac agtgagactc tgtctcagtc catgaagatg tagaggagaa     1860

actggaactc tcgagcgttg ctggggggga ttgtaaaatg gtgtgaccac tgcagaagac     1920

agtatggcag ctttcctcaa aacttcagac atagaattaa cacatgatcc tgcaattcca     1980

cttataggaa ttgacccaca agaaatgaaa gcagggactt gaacccatat ttgtacacca     2040

atattcatag cagcttattc acaagaccca aaaggcagaa gcaacccaaa tgttcatcaa     2100

tgaatgaatg aatggctaag caaaatgtga tatgtaccta acgaagtatc cttcagcctg     2160

aaagaggaat gaagtactca tacatgttac aacacggacg aaccttgaaa actttatgct     2220

aagtgaaata agccagacat caacagataa atagtttatg attccaccta catgaggtac     2280

tgagagtgaa caaatttaca gagacagaaa gcagaacagt gattaccagg gactgagggg     2340

aggggagcat gggaagtgac ggtttaatgg gcacagggtt tatgtttagg atgttgaaaa     2400

agttctgcag ataaacagta gtgatagttg taccgcaatg tgacttaatg ccactaaatt     2460

gacacttaaa aatggtttaa atggtcaatt ttgttatgta tattttatat caatttaaaa     2520

aaaaacctga gccccaaaag gtattttaat caccaaggct gattaaacca aggctagaac     2580

cacctgccta tattttttgt taaatgattt cattcaatat ctttttttta ataaaccatt     2640

tttacttggg tgttta                                                     2656


<210>  649
<211>  1615
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Synthetic nucleotide

<400>  649
acaagcacca aagcagaggg gcaggcagca caccacccag cagccagagc accagcccag       60

ccatggtcct tgaggtgagt gaccaccaag tgctaaatga cgccgaggtt gccgccctcc      120

tggagaactt cagctcttcc tatgactatg gagaaaacga gagtgactcg tgctgtacct      180

ccccgccctg cccacaggac ttcagcctga acttcgaccg ggccttcctg ccagccctct      240

acagcctcct ctttctgctg gggctgctgg gcaacggcgc ggtggcagcc gtgctgctga      300

gccggcggac agccctgagc agcaccgaca ccttcctgct ccacctagct gtagcagaca      360

cgctgctggt gctgacactg ccgctctggg cagtggacgc tgccgtccag tgggtctttg      420

gctctggcct ctgcaaagtg gcaggtgccc tcttcaacat caacttctac gcaggagccc      480

tcctgctggc ctgcatcagc tttgaccgct acctgaacat agttcatgcc acccagctct      540

accgccgggg gcccccggcc cgcgtgaccc tcacctgcct ggctgtctgg gggctctgcc      600

tgcttttcgc cctcccagac ttcatcttcc tgtcggccca ccacgacgag cgcctcaacg      660

ccacccactg ccaatacaac ttcccacagg tgggccgcac ggctctgcgg gtgctgcagc      720

tggtggctgg ctttctgctg cccctgctgg tcatggccta ctgctatgcc cacatcctgg      780

ccgtgctgct ggtttccagg ggccagcggc gcctgcgggc catgcggctg gtggtggtgg      840

tcgtggtggc ctttgccctc tgctggaccc cctatcacct ggtggtgctg gtggacatcc      900

tcatggacct gggcgctttg gcccgcaact gtggccgaga aagcagggta gacgtggcca      960

agtcggtcac ctcaggcctg ggctacatgc actgctgcct caacccgctg ctctatgcct     1020

ttgtaggggt caagttccgg gagcggatgt ggatgctgct cttgcgcctg ggctgcccca     1080

accagagagg gctccagagg cagccatcgt cttcccgccg ggattcatcc tggtctgaga     1140

cctcagaggc ctcctactcg ggcttgtgag gccggaatcc gggctcccct ttcgcccaca     1200

gtctgacttc cccgcattcc aggctcctcc ctccctctgc cggctctggc tctccccaat     1260

atcctcgctc ccgggactca ctggcagccc cagcaccacc aggtctcccg ggaagccacc     1320

ctcccagctc tgaggactgc accattgctg ctccttagct gccaagcccc atcctgccgc     1380

ccgaggtggc tgcctggagc cccactgccc ttctcatttg gaaactaaaa cttcatcttc     1440

cccaagtgcg gggagtacaa ggcatggcgt agagggtgct gccccatgaa gccacagccc     1500

aggcctccag ctcagcagtg actgtggcca tggtccccaa gacctctata tttgctcttt     1560

tatttttatg tctaaaatcc tgcttaaaac ttttcaataa acaagatcgt cagga          1615


<210>  650
<211>  1859
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Synthetic nucleotide

<400>  650
acaagcacca aagcagaggg gcaggcagca caccacccag cagccagagc accagcccag       60

ccatggtcct tgaggggtcc ctgggccgat gggatcacgc agaagaatgc gagagaagca      120

gcctttgaga agggaagtca ctatcccaga gcccaggctg agcggatgga gttgaggaag      180

tacggccctg gaagactggc ggggacagtt ataggaggag ctgctcagag taaatcacag      240

actaaatcag actcaatcac aaaagagttc ctgccaggcc tttacacagc cccttcctcc      300

ccgttcccgc cctcacaggt gagtgaccac caagtgctaa atgacgccga ggttgccgcc      360

ctcctggaga acttcagctc ttcctatgac tatggagaaa acgagagtga ctcgtgctgt      420

acctccccgc cctgcccaca ggacttcagc ctgaacttcg accgggcctt cctgccagcc      480

ctctacagcc tcctctttct gctggggctg ctgggcaacg gcgcggtggc agccgtgctg      540

ctgagccggc ggacagccct gagcagcacc gacaccttcc tgctccacct agctgtagca      600

gacacgctgc tggtgctgac actgccgctc tgggcagtgg acgctgccgt ccagtgggtc      660

tttggctctg gcctctgcaa agtggcaggt gccctcttca acatcaactt ctacgcagga      720

gccctcctgc tggcctgcat cagctttgac cgctacctga acatagttca tgccacccag      780

ctctaccgcc gggggccccc ggcccgcgtg accctcacct gcctggctgt ctgggggctc      840

tgcctgcttt tcgccctccc agacttcatc ttcctgtcgg cccaccacga cgagcgcctc      900

aacgccaccc actgccaata caacttccca caggtgggcc gcacggctct gcgggtgctg      960

cagctggtgg ctggctttct gctgcccctg ctggtcatgg cctactgcta tgcccacatc     1020

ctggccgtgc tgctggtttc caggggccag cggcgcctgc gggccatgcg gctggtggtg     1080

gtggtcgtgg tggcctttgc cctctgctgg accccctatc acctggtggt gctggtggac     1140

atcctcatgg acctgggcgc tttggcccgc aactgtggcc gagaaagcag ggtagacgtg     1200

gccaagtcgg tcacctcagg cctgggctac atgcactgct gcctcaaccc gctgctctat     1260

gcctttgtag gggtcaagtt ccgggagcgg atgtggatgc tgctcttgcg cctgggctgc     1320

cccaaccaga gagggctcca gaggcagcca tcgtcttccc gccgggattc atcctggtct     1380

gagacctcag aggcctccta ctcgggcttg tgaggccgga atccgggctc ccctttcgcc     1440

cacagtctga cttccccgca ttccaggctc ctccctccct ctgccggctc tggctctccc     1500

caatatcctc gctcccggga ctcactggca gccccagcac caccaggtct cccgggaagc     1560

caccctccca gctctgagga ctgcaccatt gctgctcctt agctgccaag ccccatcctg     1620

ccgcccgagg tggctgcctg gagccccact gcccttctca tttggaaact aaaacttcat     1680

cttccccaag tgcggggagt acaaggcatg gcgtagaggg tgctgcccca tgaagccaca     1740

gcccaggcct ccagctcagc agtgactgtg gccatggtcc ccaagacctc tatatttgct     1800

cttttatttt tatgtctaaa atcctgctta aaacttttca ataaacaaga tcgtcagga      1859


<210>  651
<211>  1904
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Synthetic nucleotide

<400>  651
cttccctcta gtgggcgggg cagaggagtt agccaagatg tgactttgaa accctcagcg       60

tctcagtgcc cttttgttct aaacaaagaa ttttgtaatt ggttctacca aagaaggata      120

taatgaagtc actatgggaa aagatgggga ggagagttgt aggattctac attaattctc      180

ttgtgccctt agcccactac ttcagaattt cctgaagaaa gcaagcctga attggttttt      240

taaattgctt taaaaatttt ttttaactgg gttaatgctt gctgaattgg aagtgaatgt      300

ccattccttt gcctcttttg cagatataca cttcagataa ctacaccgag gaaatgggct      360

caggggacta tgactccatg aaggaaccct gtttccgtga agaaaatgct aatttcaata      420

aaatcttcct gcccaccatc tactccatca tcttcttaac tggcattgtg ggcaatggat      480

tggtcatcct ggtcatgggt taccagaaga aactgagaag catgacggac aagtacaggc      540

tgcacctgtc agtggccgac ctcctctttg tcatcacgct tcccttctgg gcagttgatg      600

ccgtggcaaa ctggtacttt gggaacttcc tatgcaaggc agtccatgtc atctacacag      660

tcaacctcta cagcagtgtc ctcatcctgg ccttcatcag tctggaccgc tacctggcca      720

tcgtccacgc caccaacagt cagaggccaa ggaagctgtt ggctgaaaag gtggtctatg      780

ttggcgtctg gatccctgcc ctcctgctga ctattcccga cttcatcttt gccaacgtca      840

gtgaggcaga tgacagatat atctgtgacc gcttctaccc caatgacttg tgggtggttg      900

tgttccagtt tcagcacatc atggttggcc ttatcctgcc tggtattgtc atcctgtcct      960

gctattgcat tatcatctcc aagctgtcac actccaaggg ccaccagaag cgcaaggccc     1020

tcaagaccac agtcatcctc atcctggctt tcttcgcctg ttggctgcct tactacattg     1080

ggatcagcat cgactccttc atcctcctgg aaatcatcaa gcaagggtgt gagtttgaga     1140

acactgtgca caagtggatt tccatcaccg aggccctagc tttcttccac tgttgtctga     1200

accccatcct ctatgctttc cttggagcca aatttaaaac ctctgcccag cacgcactca     1260

cctctgtgag cagagggtcc agcctcaaga tcctctccaa aggaaagcga ggtggacatt     1320

catctgtttc cactgagtct gagtcttcaa gttttcactc cagctaacac agatgtaaaa     1380

gacttttttt tatacgataa ataacttttt tttaagttac acatttttca gatataaaag     1440

actgaccaat attgtacagt ttttattgct tgttggattt ttgtcttgtg tttctttagt     1500

ttttgtgaag tttaattgac ttatttatat aaattttttt tgtttcatat tgatgtgtgt     1560

ctaggcagga cctgtggcca agttcttagt tgctgtatgt ctcgtggtag gactgtagaa     1620

aagggaactg aacattccag agcgtgtagt gaatcacgta aagctagaaa tgatccccag     1680

ctgtttatgc atagataatc tctccattcc cgtggaacgt ttttcctgtt cttaagacgt     1740

gattttgctg tagaagatgg cacttataac caaagcccaa agtggtatag aaatgctggt     1800

ttttcagttt tcaggagtgg gttgatttca gcacctacag tgtacagtct tgtattaagt     1860

tgttaataaa agtacatgtt aaacttaaaa aaaaaaaaaa aaaa                      1904


<210>  652
<211>  1668
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Synthetic nucleotide

<400>  652
agtttgttgg ctgcggcagc aggtagcaaa gtgacgccga gggcctgagt gctccagtag       60

ccaccgcatc tggagaacca gcggttacca tggaggggat cagtatatac acttcagata      120

actacaccga ggaaatgggc tcaggggact atgactccat gaaggaaccc tgtttccgtg      180

aagaaaatgc taatttcaat aaaatcttcc tgcccaccat ctactccatc atcttcttaa      240

ctggcattgt gggcaatgga ttggtcatcc tggtcatggg ttaccagaag aaactgagaa      300

gcatgacgga caagtacagg ctgcacctgt cagtggccga cctcctcttt gtcatcacgc      360

ttcccttctg ggcagttgat gccgtggcaa actggtactt tgggaacttc ctatgcaagg      420

cagtccatgt catctacaca gtcaacctct acagcagtgt cctcatcctg gccttcatca      480

gtctggaccg ctacctggcc atcgtccacg ccaccaacag tcagaggcca aggaagctgt      540

tggctgaaaa ggtggtctat gttggcgtct ggatccctgc cctcctgctg actattcccg      600

acttcatctt tgccaacgtc agtgaggcag atgacagata tatctgtgac cgcttctacc      660

ccaatgactt gtgggtggtt gtgttccagt ttcagcacat catggttggc cttatcctgc      720

ctggtattgt catcctgtcc tgctattgca ttatcatctc caagctgtca cactccaagg      780

gccaccagaa gcgcaaggcc ctcaagacca cagtcatcct catcctggct ttcttcgcct      840

gttggctgcc ttactacatt gggatcagca tcgactcctt catcctcctg gaaatcatca      900

agcaagggtg tgagtttgag aacactgtgc acaagtggat ttccatcacc gaggccctag      960

ctttcttcca ctgttgtctg aaccccatcc tctatgcttt ccttggagcc aaatttaaaa     1020

cctctgccca gcacgcactc acctctgtga gcagagggtc cagcctcaag atcctctcca     1080

aaggaaagcg aggtggacat tcatctgttt ccactgagtc tgagtcttca agttttcact     1140

ccagctaaca cagatgtaaa agactttttt ttatacgata aataactttt ttttaagtta     1200

cacatttttc agatataaaa gactgaccaa tattgtacag tttttattgc ttgttggatt     1260

tttgtcttgt gtttctttag tttttgtgaa gtttaattga cttatttata taaatttttt     1320

ttgtttcata ttgatgtgtg tctaggcagg acctgtggcc aagttcttag ttgctgtatg     1380

tctcgtggta ggactgtaga aaagggaact gaacattcca gagcgtgtag tgaatcacgt     1440

aaagctagaa atgatcccca gctgtttatg catagataat ctctccattc ccgtggaacg     1500

tttttcctgt tcttaagacg tgattttgct gtagaagatg gcacttataa ccaaagccca     1560

aagtggtata gaaatgctgg tttttcagtt ttcaggagtg ggttgatttc agcacctaca     1620

gtgtacagtc ttgtattaag ttgttaataa aagtacatgt taaactta                  1668


<210>  653
<211>  1881
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Synthetic nucleotide

<400>  653
agtttgttgg ctgcggcagc aggtagcaaa gtgacgccga gggcctgagt gctccagtag       60

ccaccgcatc tggagaacca gcggttacca tggaggggat cagtgaaaat gccccgctcc      120

ctaacgtccc aaacgcgcca agtgataaac acgaggatgg caagagaccc acacaccgga      180

ggagcgcccg cttgggggag gaggtgccgt ttgttcattt tctgacactc ccgcccaata      240

taccccaagc accgaagggc cttcgtttta agaccgcatt ctctttaccc actacaagtt      300

gcttgaagcc cagaatgata tacacttcag ataactacac cgaggaaatg ggctcagggg      360

actatgactc catgaaggaa ccctgtttcc gtgaagaaaa tgctaatttc aataaaatct      420

tcctgcccac catctactcc atcatcttct taactggcat tgtgggcaat ggattggtca      480

tcctggtcat gggttaccag aagaaactga gaagcatgac ggacaagtac aggctgcacc      540

tgtcagtggc cgacctcctc tttgtcatca cgcttccctt ctgggcagtt gatgccgtgg      600

caaactggta ctttgggaac ttcctatgca aggcagtcca tgtcatctac acagtcaacc      660

tctacagcag tgtcctcatc ctggccttca tcagtctgga ccgctacctg gccatcgtcc      720

acgccaccaa cagtcagagg ccaaggaagc tgttggctga aaaggtggtc tatgttggcg      780

tctggatccc tgccctcctg ctgactattc ccgacttcat ctttgccaac gtcagtgagg      840

cagatgacag atatatctgt gaccgcttct accccaatga cttgtgggtg gttgtgttcc      900

agtttcagca catcatggtt ggccttatcc tgcctggtat tgtcatcctg tcctgctatt      960

gcattatcat ctccaagctg tcacactcca agggccacca gaagcgcaag gccctcaaga     1020

ccacagtcat cctcatcctg gctttcttcg cctgttggct gccttactac attgggatca     1080

gcatcgactc cttcatcctc ctggaaatca tcaagcaagg gtgtgagttt gagaacactg     1140

tgcacaagtg gatttccatc accgaggccc tagctttctt ccactgttgt ctgaacccca     1200

tcctctatgc tttccttgga gccaaattta aaacctctgc ccagcacgca ctcacctctg     1260

tgagcagagg gtccagcctc aagatcctct ccaaaggaaa gcgaggtgga cattcatctg     1320

tttccactga gtctgagtct tcaagttttc actccagcta acacagatgt aaaagacttt     1380

tttttatacg ataaataact tttttttaag ttacacattt ttcagatata aaagactgac     1440

caatattgta cagtttttat tgcttgttgg atttttgtct tgtgtttctt tagtttttgt     1500

gaagtttaat tgacttattt atataaattt tttttgtttc atattgatgt gtgtctaggc     1560

aggacctgtg gccaagttct tagttgctgt atgtctcgtg gtaggactgt agaaaaggga     1620

actgaacatt ccagagcgtg tagtgaatca cgtaaagcta gaaatgatcc ccagctgttt     1680

atgcatagat aatctctcca ttcccgtgga acgtttttcc tgttcttaag acgtgatttt     1740

gctgtagaag atggcactta taaccaaagc ccaaagtggt atagaaatgc tggtttttca     1800

gttttcagga gtgggttgat ttcagcacct acagtgtaca gtcttgtatt aagttgttaa     1860

taaaagtaca tgttaaactt a                                               1881


<210>  654
<211>  1767
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Synthetic nucleotide

<400>  654
agtttgttgg ctgcggcagc aggtagcaaa gtgacgccga gggcctgagt gctccagtag       60

ccaccgcatc tggagaacca gcggttacca tggaggggat cagtgaaaat gccccgctcc      120

ctaacgtccc aaacgcgcca agtgataaac acgaggatgg caagagaccc acacaccgga      180

ggagcgcccg cttgggggag gagatataca cttcagataa ctacaccgag gaaatgggct      240

caggggacta tgactccatg aaggaaccct gtttccgtga agaaaatgct aatttcaata      300

aaatcttcct gcccaccatc tactccatca tcttcttaac tggcattgtg ggcaatggat      360

tggtcatcct ggtcatgggt taccagaaga aactgagaag catgacggac aagtacaggc      420

tgcacctgtc agtggccgac ctcctctttg tcatcacgct tcccttctgg gcagttgatg      480

ccgtggcaaa ctggtacttt gggaacttcc tatgcaaggc agtccatgtc atctacacag      540

tcaacctcta cagcagtgtc ctcatcctgg ccttcatcag tctggaccgc tacctggcca      600

tcgtccacgc caccaacagt cagaggccaa ggaagctgtt ggctgaaaag gtggtctatg      660

ttggcgtctg gatccctgcc ctcctgctga ctattcccga cttcatcttt gccaacgtca      720

gtgaggcaga tgacagatat atctgtgacc gcttctaccc caatgacttg tgggtggttg      780

tgttccagtt tcagcacatc atggttggcc ttatcctgcc tggtattgtc atcctgtcct      840

gctattgcat tatcatctcc aagctgtcac actccaaggg ccaccagaag cgcaaggccc      900

tcaagaccac agtcatcctc atcctggctt tcttcgcctg ttggctgcct tactacattg      960

ggatcagcat cgactccttc atcctcctgg aaatcatcaa gcaagggtgt gagtttgaga     1020

acactgtgca caagtggatt tccatcaccg aggccctagc tttcttccac tgttgtctga     1080

accccatcct ctatgctttc cttggagcca aatttaaaac ctctgcccag cacgcactca     1140

cctctgtgag cagagggtcc agcctcaaga tcctctccaa aggaaagcga ggtggacatt     1200

catctgtttc cactgagtct gagtcttcaa gttttcactc cagctaacac agatgtaaaa     1260

gacttttttt tatacgataa ataacttttt tttaagttac acatttttca gatataaaag     1320

actgaccaat attgtacagt ttttattgct tgttggattt ttgtcttgtg tttctttagt     1380

ttttgtgaag tttaattgac ttatttatat aaattttttt tgtttcatat tgatgtgtgt     1440

ctaggcagga cctgtggcca agttcttagt tgctgtatgt ctcgtggtag gactgtagaa     1500

aagggaactg aacattccag agcgtgtagt gaatcacgta aagctagaaa tgatccccag     1560

ctgtttatgc atagataatc tctccattcc cgtggaacgt ttttcctgtt cttaagacgt     1620

gattttgctg tagaagatgg cacttataac caaagcccaa agtggtatag aaatgctggt     1680

ttttcagttt tcaggagtgg gttgatttca gcacctacag tgtacagtct tgtattaagt     1740

tgttaataaa agtacatgtt aaactta                                         1767


<210>  655
<211>  1905
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Synthetic nucleotide

<400>  655
agcaggattg gaatcttttt ctctgtgagt cgaggagaaa cgactggaaa gagcgttcca       60

gtggctgcat gtgtctcccc cttgagtccc gccgcgcgcg gcggcttgca cgctgtttgc      120

aaacgtaaga acattctgtg cacaagtgca gagaaggcgt gcgcgctgcc tcgggactca      180

gaccaccggt ctcttccttg gggaagcggg gatgtcttgg agcgagttac attgtctgaa      240

tttagaggcg gagggcggcg tgcctgggct gagttcccag gaggagattg cgcccgcttt      300

aacttcgggg ttaagcgcct ggtgactgtt cttgacactg gatatacact tcagataact      360

acaccgagga aatgggctca ggggactatg actccatgaa ggaaccctgt ttccgtgaag      420

aaaatgctaa tttcaataaa atcttcctgc ccaccatcta ctccatcatc ttcttaactg      480

gcattgtggg caatggattg gtcatcctgg tcatgggtta ccagaagaaa ctgagaagca      540

tgacggacaa gtacaggctg cacctgtcag tggccgacct cctctttgtc atcacgcttc      600

ccttctgggc agttgatgcc gtggcaaact ggtactttgg gaacttccta tgcaaggcag      660

tccatgtcat ctacacagtc aacctctaca gcagtgtcct catcctggcc ttcatcagtc      720

tggaccgcta cctggccatc gtccacgcca ccaacagtca gaggccaagg aagctgttgg      780

ctgaaaaggt ggtctatgtt ggcgtctgga tccctgccct cctgctgact attcccgact      840

tcatctttgc caacgtcagt gaggcagatg acagatatat ctgtgaccgc ttctacccca      900

atgacttgtg ggtggttgtg ttccagtttc agcacatcat ggttggcctt atcctgcctg      960

gtattgtcat cctgtcctgc tattgcatta tcatctccaa gctgtcacac tccaagggcc     1020

accagaagcg caaggccctc aagaccacag tcatcctcat cctggctttc ttcgcctgtt     1080

ggctgcctta ctacattggg atcagcatcg actccttcat cctcctggaa atcatcaagc     1140

aagggtgtga gtttgagaac actgtgcaca agtggatttc catcaccgag gccctagctt     1200

tcttccactg ttgtctgaac cccatcctct atgctttcct tggagccaaa tttaaaacct     1260

ctgcccagca cgcactcacc tctgtgagca gagggtccag cctcaagatc ctctccaaag     1320

gaaagcgagg tggacattca tctgtttcca ctgagtctga gtcttcaagt tttcactcca     1380

gctaacacag atgtaaaaga ctttttttta tacgataaat aacttttttt taagttacac     1440

atttttcaga tataaaagac tgaccaatat tgtacagttt ttattgcttg ttggattttt     1500

gtcttgtgtt tctttagttt ttgtgaagtt taattgactt atttatataa attttttttg     1560

tttcatattg atgtgtgtct aggcaggacc tgtggccaag ttcttagttg ctgtatgtct     1620

cgtggtagga ctgtagaaaa gggaactgaa cattccagag cgtgtagtga atcacgtaaa     1680

gctagaaatg atccccagct gtttatgcat agataatctc tccattcccg tggaacgttt     1740

ttcctgttct taagacgtga ttttgctgta gaagatggca cttataacca aagcccaaag     1800

tggtatagaa atgctggttt ttcagttttc aggagtgggt tgatttcagc acctacagtg     1860

tacagtcttg tattaagttg ttaataaaag tacatgttaa actta                     1905


<210>  656
<211>  4293
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Synthetic nucleotide

<400>  656
ctctcaacat aagacagtga ccagtctggt gactcacagc cggcacagcc atgaactacc       60

cgctaacgct ggaaatggac ctcgagaacc tggaggacct gttctgggaa ctggacagat      120

tggacaacta taacgacacc tccctggtgg aaaatcatct ctgccctgcc acagaggggc      180

ccctcatggc ctccttcaag gccgtgttcg tgcccgtggc ctacagcctc atcttcctcc      240

tgggcgtgat cggcaacgtc ctggtgctgg tgatcctgga gcggcaccgg cagacacgca      300

gttccacgga gaccttcctg ttccacctgg ccgtggccga cctcctgctg gtcttcatct      360

tgccctttgc cgtggccgag ggctctgtgg gctgggtcct ggggaccttc ctctgcaaaa      420

ctgtgattgc cctgcacaaa gtcaacttct actgcagcag cctgctcctg gcctgcatcg      480

ccgtggaccg ctacctggcc attgtccacg ccgtccatgc ctaccgccac cgccgcctcc      540

tctccatcca catcacctgt gggaccatct ggctggtggg cttcctcctt gccttgccag      600

agattctctt cgccaaagtc agccaaggcc atcacaacaa ctccctgcca cgttgcacct      660

tctcccaaga gaaccaagca gaaacgcatg cctggttcac ctcccgattc ctctaccatg      720

tggcgggatt cctgctgccc atgctggtga tgggctggtg ctacgtgggg gtagtgcaca      780

ggttgcgcca ggcccagcgg cgccctcagc ggcagaaggc agtcagggtg gccatcctgg      840

tgacaagcat cttcttcctc tgctggtcac cctaccacat cgtcatcttc ctggacaccc      900

tggcgaggct gaaggccgtg gacaatacct gcaagctgaa tggctctctc cccgtggcca      960

tcaccatgtg tgagttcctg ggcctggccc actgctgcct caaccccatg ctctacactt     1020

tcgccggcgt gaagttccgc agtgacctgt cgcggctcct gacgaagctg ggctgtaccg     1080

gccctgcctc cctgtgccag ctcttcccta gctggcgcag gagcagtctc tctgagtcag     1140

agaatgccac ctctctcacc acgttctagg tcccagtgtc cccttttatt gctgcttttc     1200

cttggggcag gcagtgatgc tggatgctcc ttccaacagg agctgggatc ctaagggctc     1260

accgtggcta agagtgtcct aggagtatcc tcatttgggg tagctagagg aaccaacccc     1320

catttctaga acatccctgc cagctcttct gccggccctg gggctaggct ggagcccagg     1380

gagcggaaag cagctcaaag gcacagtgaa ggctgtcctt acccatctgc acccccctgg     1440

gctgagagaa cctcacgcac ctcccatcct aatcatccaa tgctcaagaa acaacttcta     1500

cttctgccct tgccaacgga gagcgcctgc ccctcccaga acacactcca tcagcttagg     1560

ggctgctgac ctccacagct tcccctctct cctcctgccc acctgtcaaa caaagccaga     1620

agctgagcac caggggatga gtggaggtta aggctgagga aaggccagct ggcagcagag     1680

tgtggccttc ggacaactca gtccctaaaa acacagacat tctgccaggc ccccaagcct     1740

gcagtcatct tgaccaagca ggaagctcag actggttgag ttcaggtagc tgcccctggc     1800

tctgaccgaa acagcgctgg gtccacccca tgtcaccgga tcctgggtgg tctgcaggca     1860

gggctgactc taggtgccct tggaggccag ccagtgacct gaggaagcgt gaaggccgag     1920

aagcaagaaa gaaacccgac agagggaaga aaagagcttt cttcccgaac cccaaggagg     1980

gagatggatc aatcaaaccc ggcggtcccc tccgccaggc gagatggggt ggggtggaga     2040

actcctaggg tggctgggtc caggggatgg gaggttgtgg gcattgatgg ggaaggaggc     2100

tggcttgtcc cctcctcact cccttcccat aagctataga cccgaggaaa ctcagagtcg     2160

gaacggagaa aggtggactg gaaggggccc gtgggagtca tctcaaccat cccctccgtg     2220

gcatcacctt aggcagggaa gtgtaagaaa cacactgagg cagggaagtc cccaggcccc     2280

aggaagccgt gccctgcccc cgtgaggatg tcactcagat ggaaccgcag gaagctgctc     2340

cgtgcttgtt tgctcacctg gggtgtggga ggcccgtccg gcagttctgg gtgctcccta     2400

ccacctcccc agcctttgat caggtgggga gtcagggacc cctgcccttg tcccactcaa     2460

gccaagcagc caagctcctt gggaggcccc actggggaaa taacagctgt ggctcacgtg     2520

agagtgtctt cacggcagga caacgaggaa gccctaagac gtcccttttt tctctgagta     2580

tctcctcgca agctgggtaa tcgatggggg agtctgaagc agatgcaaag aggcaagagg     2640

ctggattttg aattttcttt ttaataaaaa ggcacctata aaacaggtca atacagtaca     2700

ggcagcacag agacccccgg aacaagccta aaaattgttt caaaataaaa accaagaaga     2760

tgtcttcaca tattgtattt atatatttat atttatatat atatttatat aatggtacaa     2820

aatggctggg ggtgtggcca tggatggagg gaagagtagg ctggcctgtg gcgtgggtgg     2880

gaggagaggg gacggagagg gcactcggcc cgctgcaatc tgacccctct ctcctcaggg     2940

caggaaacac agagtcagac agtttggggg ggtcttgggc caggggtgga gggctcaagg     3000

gcacagggcc caggctgagg cagggcgggc aaagcgcctg gcaggatgaa gggcaagtgg     3060

ccccccaaac acagaggccc tggccatgga ccctgggagg tgaccggggt gagtcagggg     3120

cctgttgtca gccccagagg aagcgctgga cctggccgat ggtgggccga gaggacagca     3180

ccaggctggg agaagtgggg cgagttccct ttgtattaca gctgccagtg caagaccagg     3240

ccctccaggc caggaaggct agggacgggt cctggtagaa gacaccctgt ctagaatggc     3300

ccttggtcct ggaggtgggg cgcaaaaggc ctcagccagg gaactgccct gccacctccc     3360

gaggcaggaa aggaagtgag aaaaggagaa gtttttttac tcctggggcc aaagtagggg     3420

gacaaacacc cagtcgtata tggcttcagc tctgaccaaa ggcggatagg gagctctcct     3480

gggtaggagc agggagccaa gggggaggca gtggctgtgc ctgggtgggc acagacagat     3540

ctggtacatg gccctgagcc ctgggcagag ggacaacctt gccggtgagt gggcaggcag     3600

agaggaggcg gcaggatgct gtttccccga ttccatcctc agggagtgga gactggaggg     3660

gaggtgcact gactcagatg aactgttctc ccccttcttt gataagaagt aggtggcagc     3720

agcctctgga aaagtcaggg ccctggaggt tacctggccc agggctacta cagccacagg     3780

ccccagtggc accatgccac cccttccatg gctccactca agggggccac acagccaccg     3840

cctcttcctc ctttccttca tcccaaactg ggacaaaaga cttcaagttc tggctaagat     3900

gtagcagcag cggatgcccg ggcatccaaa gtggaaagcc agggccccgt gtcaccggtg     3960

tgggcaaaca cacatgcacg tgcacacatg ttctccctga atcactcagc agcagacagg     4020

ctgccgccct gggggtctca gccctgctag ggctcaccag gtggaagcct aggtggtctg     4080

acctcagttt aggagtgggt catttacgtc atcttaccat ttggggacga gacaggaatg     4140

gtatccctta gggacccaga gacactgcaa acagtgggtg gccatgtagg gctgcatgtc     4200

cctgggtcca ggggaatgga gggagcaata acttgaagaa ggggggaagg gtttctttta     4260

tccttttttt tttgtgtgac ttctatcaaa aca                                  4293


<210>  657
<211>  2896
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Synthetic nucleotide

<400>  657
ccactctaag gaatgcggtc cctttgacag gcgaaaaact gaagttggaa aagacaaagt       60

gatttgttca aaattgaaat ttgaaacttg acatttggtc agtgggccct atgtaggaaa      120

aaacctccaa gagagctagg gttcctctca gagaggaaag acaggtcctt aggtcctcac      180

cctcccgtct ccttgccctt gcagttctgg gaactggaca gattggacaa ctataacgac      240

acctccctgg tggaaaatca tctctgccct gccacagagg ggcccctcat ggcctccttc      300

aaggccgtgt tcgtgcccgt ggcctacagc ctcatcttcc tcctgggcgt gatcggcaac      360

gtcctggtgc tggtgatcct ggagcggcac cggcagacac gcagttccac ggagaccttc      420

ctgttccacc tggccgtggc cgacctcctg ctggtcttca tcttgccctt tgccgtggcc      480

gagggctctg tgggctgggt cctggggacc ttcctctgca aaactgtgat tgccctgcac      540

aaagtcaact tctactgcag cagcctgctc ctggcctgca tcgccgtgga ccgctacctg      600

gccattgtcc acgccgtcca tgcctaccgc caccgccgcc tcctctccat ccacatcacc      660

tgtgggacca tctggctggt gggcttcctc cttgccttgc cagagattct cttcgccaaa      720

gtcagccaag gccatcacaa caactccctg ccacgttgca ccttctccca agagaaccaa      780

gcagaaacgc atgcctggtt cacctcccga ttcctctacc atgtggcggg attcctgctg      840

cccatgctgg tgatgggctg gtgctacgtg ggggtagtgc acaggttgcg ccaggcccag      900

cggcgccctc agcggcagaa ggcagtcagg gtggccatcc tggtgacaag catcttcttc      960

ctctgctggt caccctacca catcgtcatc ttcctggaca ccctggcgag gctgaaggcc     1020

gtggacaata cctgcaagct gaatggctct ctccccgtgg ccatcaccat gtgtgagttc     1080

ctgggcctgg cccactgctg cctcaacccc atgctctaca ctttcgccgg cgtgaagttc     1140

cgcagtgacc tgtcgcggct cctgacgaag ctgggctgta ccggccctgc ctccctgtgc     1200

cagctcttcc ctagctggcg caggagcagt ctctctgagt cagagaatgc cacctctctc     1260

accacgttct aggtcccagt gtcccctttt attgctgctt ttccttgggg caggcagtga     1320

tgctggatgc tccttccaac aggagctggg atcctaaggg ctcaccgtgg ctaagagtgt     1380

cctaggagta tcctcatttg gggtagctag aggaaccaac ccccatttct agaacatccc     1440

tgccagctct tctgccggcc ctggggctag gctggagccc agggagcgga aagcagctca     1500

aaggcacagt gaaggctgtc cttacccatc tgcacccccc tgggctgaga gaacctcacg     1560

cacctcccat cctaatcatc caatgctcaa gaaacaactt ctacttctgc ccttgccaac     1620

ggagagcgcc tgcccctccc agaacacact ccatcagctt aggggctgct gacctccaca     1680

gcttcccctc tctcctcctg cccacctgtc aaacaaagcc agaagctgag caccagggga     1740

tgagtggagg ttaaggctga ggaaaggcca gctggcagca gagtgtggcc ttcggacaac     1800

tcagtcccta aaaacacaga cattctgcca ggcccccaag cctgcagtca tcttgaccaa     1860

gcaggaagct cagactggtt gagttcaggt agctgcccct ggctctgacc gaaacagcgc     1920

tgggtccacc ccatgtcacc ggatcctggg tggtctgcag gcagggctga ctctaggtgc     1980

ccttggaggc cagccagtga cctgaggaag cgtgaaggcc gagaagcaag aaagaaaccc     2040

gacagaggga agaaaagagc tttcttcccg aaccccaagg agggagatgg atcaatcaaa     2100

cccggcggtc ccctccgcca ggcgagatgg ggtggggtgg agaactccta gggtggctgg     2160

gtccagggga tgggaggttg tgggcattga tggggaagga ggctggcttg tcccctcctc     2220

actcccttcc cataagctat agacccgagg aaactcagag tcggaacgga gaaaggtgga     2280

ctggaagggg cccgtgggag tcatctcaac catcccctcc gtggcatcac cttaggcagg     2340

gaagtgtaag aaacacactg aggcagggaa gtccccaggc cccaggaagc cgtgccctgc     2400

ccccgtgagg atgtcactca gatggaaccg caggaagctg ctccgtgctt gtttgctcac     2460

ctggggtgtg ggaggcccgt ccggcagttc tgggtgctcc ctaccacctc cccagccttt     2520

gatcaggtgg ggagtcaggg acccctgccc ttgtcccact caagccaagc agccaagctc     2580

cttgggaggc cccactgggg aaataacagc tgtggctcac gtgagagtgt cttcacggca     2640

ggacaacgag gaagccctaa gacgtccctt ttttctctga gtatctcctc gcaagctggg     2700

taatcgatgg gggagtctga agcagatgca aagaggcaag aggctggatt ttgaattttc     2760

tttttaataa aaaggcacct ataaaacagg tcaatacagt acaggcagca cagagacccc     2820

cggaacaagc ctaaaaattg tttcaaaata aaaaccaaga agatgtcttc acatattgta     2880

aaaaaaaaaa aaaaaa                                                     2896


<210>  658
<211>  2323
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Synthetic nucleotide

<400>  658
agatctgttt ggttcagttg ctgagaagcc tgacatacca ggactgcctg agacaagcca       60

caagctgaac agagaaagtg gattgaacaa ggacgcattt ccccagtaca tccacaacat      120

gctgtccaca tctcgttctc ggtttatcag aaataccaac gagagcggtg aagaagtcac      180

cacctttttt gattatgatt acggtgctcc ctgtcataaa tttgacgtga agcaaattgg      240

ggcccaactc ctgcctccgc tctactcgct ggtgttcatc tttggttttg tgggcaacat      300

gctggtcgtc ctcatcttaa taaactgcaa aaagctgaag tgcttgactg acatttacct      360

gctcaacctg gccatctctg atctgctttt tcttattact ctcccattgt gggctcactc      420

tgctgcaaat gagtgggtct ttgggaatgc aatgtgcaaa ttattcacag ggctgtatca      480

catcggttat tttggcggaa tcttcttcat catcctcctg acaatcgata gatacctggc      540

tattgtccat gctgtgtttg ctttaaaagc caggacggtc acctttgggg tggtgacaag      600

tgtgatcacc tggttggtgg ctgtgtttgc ttctgtccca ggaatcatct ttactaaatg      660

ccagaaagaa gattctgttt atgtctgtgg cccttatttt ccacgaggat ggaataattt      720

ccacacaata atgaggaaca ttttggggct ggtcctgccg ctgctcatca tggtcatctg      780

ctactcggga atcctgaaaa ccctgcttcg gtgtcgaaac gagaagaaga ggcatagggc      840

agtgagagtc atcttcacca tcatgattgt ttactttctc ttctggactc cctataatat      900

tgtcattctc ctgaacacct tccaggaatt cttcggcctg agtaactgtg aaagcaccag      960

tcaactggac caagccacgc aggtgacaga gactcttggg atgactcact gctgcatcaa     1020

tcccatcatc tatgccttcg ttggggagaa gttcagaagc ctttttcaca tagctcttgg     1080

ctgtaggatt gccccactcc aaaaaccagt gtgtggaggt ccaggagtga gaccaggaaa     1140

gaatgtgaaa gtgactacac aaggactcct cgatggtcgt ggaaaaggaa agtcaattgg     1200

cagagcccct gaagccagtc ttcaggacaa agaaggagcc tagagacaga aatgacagat     1260

ctctgctttg gaaatcacac gtctggcttc acagatgtgt gattcacagt gtgaatcttg     1320

gtgtctacgt taccaggcag gaaggctgag aggagagaga ctccagctgg gttggaaaac     1380

agtattttcc aaactacctt ccagttcctc atttttgaat acaggcatag agttcagact     1440

ttttttaaat agtaaaaata aaattaaagc tgaaaactgc aacttgtaaa tgtggtaaag     1500

agttagtttg agttactatc atgtcaaacg tgaaaatgct gtattagtca cagagataat     1560

tctagctttg agcttaagaa ttttgagcag gtggtatgtt tgggagactg ctgagtcaac     1620

ccaatagttg ttgattggca ggagttggaa gtgtgtgatc tgtgggcaca ttagcctatg     1680

tgcatgcagc atctaagtaa tgatgtcgtt tgaatcacag tatacgctcc atcgctgtca     1740

tctcagctgg atctccattc tctcaggctt gctgccaaaa gccttttgtg ttttgttttg     1800

tatcattatg aagtcatgcg tttaatcaca ttcgagtgtt tcagtgcttc gcagatgtcc     1860

ttgatgctca tattgttccc tattttgcca gtgggaactc ctaaatcaag ttggcttcta     1920

atcaaagctt ttaaacccta ttggtaaaga atggaaggtg gagaagctcc ctgaagtaag     1980

caaagacttt cctcttagtc gagccaagtt aagaatgttc ttatgttgcc cagtgtgttt     2040

ctgatctgat gcaagcaaga aacactgggc ttctagaacc aggcaacttg ggaactagac     2100

tcccaagctg gactatggct ctactttcag gccacatggc taaagaaggt ttcagaaaga     2160

agtggggaca gagcagaact ttcaccttca tatatttgta tgatcctaat gaatgcataa     2220

aatgttaagt tgatggtgat gaaatgtaaa tactgttttt aacaactatg atttggaaaa     2280

taaatcaatg ctataactat gttgataaaa gatttaaaaa caa                       2323


<210>  659
<211>  3531
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Synthetic nucleotide

<400>  659
agatctgttt ggttcagttg ctgagaagcc tgacatacca ggactgcctg agacaagcca       60

caagctgaac agagaaagtg gattgaacaa ggacgcattt ccccagtaca tccacaacat      120

gctgtccaca tctcgttctc ggtttatcag aaataccaac gagagcggtg aagaagtcac      180

cacctttttt gattatgatt acggtgctcc ctgtcataaa tttgacgtga agcaaattgg      240

ggcccaactc ctgcctccgc tctactcgct ggtgttcatc tttggttttg tgggcaacat      300

gctggtcgtc ctcatcttaa taaactgcaa aaagctgaag tgcttgactg acatttacct      360

gctcaacctg gccatctctg atctgctttt tcttattact ctcccattgt gggctcactc      420

tgctgcaaat gagtgggtct ttgggaatgc aatgtgcaaa ttattcacag ggctgtatca      480

catcggttat tttggcggaa tcttcttcat catcctcctg acaatcgata gatacctggc      540

tattgtccat gctgtgtttg ctttaaaagc caggacggtc acctttgggg tggtgacaag      600

tgtgatcacc tggttggtgg ctgtgtttgc ttctgtccca ggaatcatct ttactaaatg      660

ccagaaagaa gattctgttt atgtctgtgg cccttatttt ccacgaggat ggaataattt      720

ccacacaata atgaggaaca ttttggggct ggtcctgccg ctgctcatca tggtcatctg      780

ctactcggga atcctgaaaa ccctgcttcg gtgtcgaaac gagaagaaga ggcatagggc      840

agtgagagtc atcttcacca tcatgattgt ttactttctc ttctggactc cctataatat      900

tgtcattctc ctgaacacct tccaggaatt cttcggcctg agtaactgtg aaagcaccag      960

tcaactggac caagccacgc aggtgacaga gactcttggg atgactcact gctgcatcaa     1020

tcccatcatc tatgccttcg ttggggagaa gttcagaagg tatctctcgg tgttcttccg     1080

aaagcacatc accaagcgct tctgcaaaca atgtccagtt ttctacaggg agacagtgga     1140

tggagtgact tcaacaaaca cgccttccac tggggagcag gaagtctcgg ctggtttata     1200

aaacgaggag cagtttgatt gttgtttata aagggagata acaatctgta tataacaaca     1260

aacttcaagg gtttgttgaa caatagaaac ctgtaaagca ggtgcccagg aacctcaggg     1320

ctgtgtgtac taatacagac tatgtcaccc aatgcatatc caacatgtgc tcagggaata     1380

atccagaaaa actgtgggta gagactttga ctctccagaa agctcatctc agctcctgaa     1440

aaatgcctca ttaccttgtg ctaatcctct ttttctagtc ttcataattt cttcactcaa     1500

tctctgattc tgtcaatgtc ttgaaatcaa gggccagctg gaggtgaaga agagaatgtg     1560

acaggcacag atgaatggga gtgagggata gtggggtcag ggctgagagg agaaggaggg     1620

agacatgagc atggctgagc ctggacaaag acaaaggtga gcaaagggct cacgcattca     1680

gccaggagat gatactggtc cttagcccca tctgccacgt gtatttaacc ttgaagggtt     1740

caccaggtca gggagagttt gggaactgca ataacctggg agttttggtg gagtccgatg     1800

attctctttt gcataagtgc atgacatatt tttgctttat tacagtttat ctatggcacc     1860

catgcacctt acatttgaaa tctatgaaat atcatgctcc attgttcaga tgcttcttag     1920

gccacatccc cctgtctaaa aattcagaaa atttttgttt ataaaagatg cattatctat     1980

gatatgctaa tatatgtata tgcaatatat ataggctctt gcttgatctc tccaggaggt     2040

agtgattatg agaagggggt ggagaatgat gagttccttc accaggagca aaggacgggg     2100

atcgtgtgga accactgcag aactatttcc gaaatcaact aagtggagag agccaggaag     2160

gctgcatcag aacccagtaa agcttcttgt ctggatctga gctggtttgt tttgtgcttg     2220

cttttccctg ccttgccact cccctcactc ttctcttttc cccacagcct ttttcacata     2280

gctcttggct gtaggattgc cccactccaa aaaccagtgt gtggaggtcc aggagtgaga     2340

ccaggaaaga atgtgaaagt gactacacaa ggactcctcg atggtcgtgg aaaaggaaag     2400

tcaattggca gagcccctga agccagtctt caggacaaag aaggagccta gagacagaaa     2460

tgacagatct ctgctttgga aatcacacgt ctggcttcac agatgtgtga ttcacagtgt     2520

gaatcttggt gtctacgtta ccaggcagga aggctgagag gagagagact ccagctgggt     2580

tggaaaacag tattttccaa actaccttcc agttcctcat ttttgaatac aggcatagag     2640

ttcagacttt ttttaaatag taaaaataaa attaaagctg aaaactgcaa cttgtaaatg     2700

tggtaaagag ttagtttgag ttactatcat gtcaaacgtg aaaatgctgt attagtcaca     2760

gagataattc tagctttgag cttaagaatt ttgagcaggt ggtatgtttg ggagactgct     2820

gagtcaaccc aatagttgtt gattggcagg agttggaagt gtgtgatctg tgggcacatt     2880

agcctatgtg catgcagcat ctaagtaatg atgtcgtttg aatcacagta tacgctccat     2940

cgctgtcatc tcagctggat ctccattctc tcaggcttgc tgccaaaagc cttttgtgtt     3000

ttgttttgta tcattatgaa gtcatgcgtt taatcacatt cgagtgtttc agtgcttcgc     3060

agatgtcctt gatgctcata ttgttcccta ttttgccagt gggaactcct aaatcaagtt     3120

ggcttctaat caaagctttt aaaccctatt ggtaaagaat ggaaggtgga gaagctccct     3180

gaagtaagca aagactttcc tcttagtcga gccaagttaa gaatgttctt atgttgccca     3240

gtgtgtttct gatctgatgc aagcaagaaa cactgggctt ctagaaccag gcaacttggg     3300

aactagactc ccaagctgga ctatggctct actttcaggc cacatggcta aagaaggttt     3360

cagaaagaag tggggacaga gcagaacttt caccttcata tatttgtatg atcctaatga     3420

atgcataaaa tgttaagttg atggtgatga aatgtaaata ctgtttttaa caactatgat     3480

ttggaaaata aatcaatgct ataactatgt tgataaaaga tttaaaaaca a              3531


<210>  660
<211>  3025
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Synthetic nucleotide

<400>  660
ggcattgcct cacagacctt cctcagagcc gctttcagaa aagcaagctg cttctggttg       60

ggcccagacc tgccttgagg agcctgtaga gttaaaaaat gaaccccacg gatatagcag      120

acaccaccct cgatgaaagc atatacagca attactatct gtatgaaagt atccccaagc      180

cttgcaccaa agaaggcatc aaggcatttg gggagctctt cctgccccca ctgtattcct      240

tggtttttgt atttggtctg cttggaaatt ctgtggtggt tctggtcctg ttcaaataca      300

agcggctcag gtccatgact gatgtgtacc tgctcaacct tgccatctcg gatctgctct      360

tcgtgttttc cctccctttt tggggctact atgcagcaga ccagtgggtt tttgggctag      420

gtctgtgcaa gatgatttcc tggatgtact tggtgggctt ttacagtggc atattctttg      480

tcatgctcat gagcattgat agatacctgg caattgtgca cgcggtgttt tccttgaggg      540

caaggacctt gacttatggg gtcatcacca gtttggctac atggtcagtg gctgtgttcg      600

cctcccttcc tggctttctg ttcagcactt gttatactga gcgcaaccat acctactgca      660

aaaccaagta ctctctcaac tccacgacgt ggaaggttct cagctccctg gaaatcaaca      720

ttctcggatt ggtgatcccc ttagggatca tgctgttttg ctactccatg atcatcagga      780

ccttgcagca ttgtaaaaat gagaagaaga acaaggcggt gaagatgatc tttgccgtgg      840

tggtcctctt ccttgggttc tggacacctt acaacatagt gctcttccta gagaccctgg      900

tggagctaga agtccttcag gactgcacct ttgaaagata cttggactat gccatccagg      960

ccacagaaac tctggctttt gttcactgct gccttaatcc catcatctac ttttttctgg     1020

gggagaaatt tcgcaagtac atcctacagc tcttcaaaac ctgcaggggc ctttttgtgc     1080

tctgccaata ctgtgggctc ctccaaattt actctgctga cacccccagc tcatcttaca     1140

cgcagtccac catggatcat gatctccatg atgctctgta gaaaaatgaa atggtgaaat     1200

gcagagtcaa tgaactttcc acattcagag cttacttaaa attgtatttt agtaagagat     1260

tcctgagcca gtgtcaggag gaaggcttac acccacagtg gaaagacagc ttctcatcct     1320

gcaggcagct ttttctctcc cactagacaa gtccagcctg gcaagggttc acctgggctg     1380

aggcatcctt cctcacacca ggcttgcctg caggcatgag tcagtctgat gagaactctg     1440

agcagtgctt gaatgaagtt gtaggtaata ttgcaaggca aagactattc ccttctaacc     1500

tgaactgatg ggtttctcca gagggaattg cagagtactg gctgatggag taaatcgcta     1560

ccttttgctg tggcaaatgg gccctctaat taatttcttg cttttgcgga acaatataga     1620

taactgtttt tctaataaca tatctcaggc aaagtatatt ccattgagcc agatgtatga     1680

agaaacaatt agcgaagtga tgaaaccaga tctcaattat ttattgtaaa ggattatctg     1740

ttaattgaaa ccaaactttt tatactgata taagggtaag gatatgaaga cattagccaa     1800

ggtctgcttt ccaaacgtga actacaaggc attcaaaatc caaacatatt tatgaaaatt     1860

caaacacagt ttctcacttg tttgtggaca tgttttgttc taattttaac agaggaatat     1920

taaaaaattt taaataggct gggcacggtg gcctgtaatc ccagcactgt gggaggccaa     1980

ggtgggcgga tcacctgagg tcaggagttc gagaccagcc tggccaacat ggagaaaccc     2040

tgtctctact aaaaaataca aaattagcca ggtgtggtgg cgcatgcctg taatcccagc     2100

tactcaggag gctgaggctg gagaataact tgaatccggg aggtggaggt tgcggtgagc     2160

cgagatcgcg ccattgtact ccaacctggg caaaaagagc gaaactctgt ctcaaaaaaa     2220

aaaaaaaaaa attaaataat acataggcca agaatacatt tatttgaggt catttacttg     2280

tttttttttt tttttttttt tttgagatgg aatcttgctc tgtcacccag tctggagtgc     2340

agtggcgcga tctcggctca ctgcaagctc tgcctcacgg gttcgcacca ttctcctgcc     2400

tcagcctccc aagtaggtgg gactacaggc acctgccccc atgcctggct aattttttgt     2460

attttcagta gagatggggt ttcaccatgt tagcaaggat ggttttaatc tcctgacctc     2520

gtgatccacc cgcctcggcc tcccaaagtg ctgggattac aggtgtgagc catcacgccc     2580

ggccacttgt ttatttttta ttttatttta ttttattttt gagatggagt ctcactctgt     2640

cacccaagct ggagtgcagt ggcactcggt tcactgcaaa gtctgcctcc caggttcaag     2700

cgattctcct gcctcagctt ctcaagcagc tgggattaga ggtgtgcacc actacgccag     2760

gctaattttt gtatttttag tagagatggg gtttcaccat attggccagg ctagtcttga     2820

actcctgacc tcaggtgatc tgcctgcttc agcctcccaa agtgctggga ttacaggcgt     2880

gagccacctc gcccagccaa ggtcttttac ttgtttataa acagtctctt cataattaaa     2940

attaaggatt aataaagtat gacaatacct ccttaatcat tttgaagtgc ctgctatcaa     3000

ttgaaataaa aacaatcaac taaaa                                           3025


<210>  661
<211>  3228
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Synthetic nucleotide

<400>  661
agcacaccac ccagtgtatg ggtgaaggag gcagcagtgt ggccggagag gagagctggg       60

ctgggagcac aggaaggtcc ccaggactct gtggtcatca gtaagagagg gcccacgtgt      120

atatgctggt gaacagaaat gtcaaccttt tcaaagtctg acatttaaga gaaaaaactg      180

tggctgttgg tttgtggaac agacagctcc ttctttattg agtcacctct actttcctgc      240

taccgctgcc tgtgagctga aggggctgaa ccatacactc ctttttctac aaccagcttg      300

cattttttct gcccacaatg agcggggaat caatgaattt cagcgatgtt ttcgactcca      360

gtgaagatta ttttgtgtca gtcaatactt catattactc agttgattct gagatgttac      420

tgtgctcctt gcaggaggtc aggcagttct ccaggctatt tgtaccgatt gcctactcct      480

tgatctgtgt ctttggcctc ctggggaata ttctggtggt gatcaccttt gctttttata      540

agaaggccag gtctatgaca gacgtctatc tcttgaacat ggccattgca gacatcctct      600

ttgttcttac tctcccattc tgggcagtga gtcatgccac cggtgcgtgg gttttcagca      660

atgccacgtg caagttgcta aaaggcatct atgccatcaa ctttaactgc gggatgctgc      720

tcctgacttg cattagcatg gaccggtaca tcgccattgt acaggcgact aagtcattcc      780

ggctccgatc cagaacacta ccgcgcagca aaatcatctg ccttgttgtg tgggggctgt      840

cagtcatcat ctccagctca acttttgtct tcaaccaaaa atacaacacc caaggcagcg      900

atgtctgtga acccaagtac cagactgtct cggagcccat caggtggaag ctgctgatgt      960

tggggcttga gctactcttt ggtttcttta tccctttgat gttcatgata ttttgttaca     1020

cgttcattgt caaaaccttg gtgcaagctc agaattctaa aaggcacaaa gccatccgtg     1080

taatcatagc tgtggtgctt gtgtttctgg cttgtcagat tcctcataac atggtcctgc     1140

ttgtgacggc tgcaaatttg ggtaaaatga accgatcctg ccagagcgaa aagctaattg     1200

gctatacgaa aactgtcaca gaagtcctgg ctttcctgca ctgctgcctg aaccctgtgc     1260

tctacgcttt tattgggcag aagttcagaa actactttct gaagatcttg aaggacctgt     1320

ggtgtgtgag aaggaagtac aagtcctcag gcttctcctg tgccgggagg tactcagaaa     1380

acatttctcg gcagaccagt gagaccgcag ataacgacaa tgcgtcgtcc ttcactatgt     1440

gatagaaagc tgagtctccc taaggcatgt gtgaaacata ctcatagatg ttatgcaaaa     1500

aaaagtctat ggccaggtat gcatggaaaa tgtgggaatt aagcaaaatc aagcaagcct     1560

ctctcctgcg ggacttaacg tgctcatggg ctgtgtgatc tcttcagggt ggggtggtct     1620

ctgataggta gcattttcca gcactttgca aggaatgttt tgtagctcta gggtatatat     1680

ccgcctggca tttcacaaaa cagcctttgg gaaatgctga attaaagtga attgttgaca     1740

aatgtaaaca ttttcagaaa tattcatgaa gcggtcacag atcacagtgt cttttggtta     1800

cagcacaaaa tgatggcagt ggtttgaaaa actaaaacag aaaaaaaaat ggaagccaac     1860

acatcactca ttttaggcaa atgtttaaac atttttatct atcagaatgt ttattgttgc     1920

tggttataag cagcaggatt ggccggctag tgtttcctct catttccctt tgatacagtc     1980

aacaagcctg accctgtaaa atggaggtgg aaagacaagc tcaagtgttc acaacctgga     2040

agtgcttcgg gaagaagggg acaatggcag aacaggtgtt ggtgacaatt gtcaccaatt     2100

ggataaagca gctcaggttg tagtgggcca ttaggaaact gtcggtttgc tttgatttcc     2160

ctgggagctg ttctctgtcg tgagtgtctc ttgtctaaac gtccattaag ctgagagtgc     2220

tatgaagaca ggatctagaa taatcttgct cacagctgtg ctctgagtgc ctagcggagt     2280

tccagcaaac aaaatggact caagagagat ttgattaatg aatcgtaatg aagttggggt     2340

ttattgtaca gtttaaaatg ttagatgttt ttaatttttt aaataaatgg aatacttttt     2400

tttttttttt aaagaaagca actttactga gacaatgtag aaagaagttt tgttccgttt     2460

ctttaatgtg gttgaagagc aatgtgtggc tgaagacttt tgttatgagg agctgcagat     2520

tagctagggg acagctggaa ttatgctggc ttctgataat tattttaaag gggtctgaaa     2580

tttgtgatgg aatcagattt taacagctct cttcaatgac atagaaagtt catggaactc     2640

atgtttttaa agggctatgt aaatatatga acattagaaa aatagcaact tgtgttacaa     2700

aaatacaaac acatgttagg aaggtactgt catgggctag gcatggtggc tcacacctgt     2760

aatcccagca ttttgggaag ctaagatggg tggatcactt gaggtcagga gtttgagacc     2820

agcctggcca acatggcgaa acccctctct actaaaaata caaaaatttg ccaggcgtgg     2880

tggcgggtgc ctgtaatccc agctacttgg gaggctgagg caagagaatc gcttgaaccc     2940

aggaggcaga ggttgcagtg agccgagatc gtgccattgc actccagcct gggtgacaaa     3000

gcgagactcc atctcaaaaa aaaaaaaaaa aaaaaaggaa agaactgtca tgtaaacata     3060

ccaacatgtt taaacctgac aatggtgtta tttgaaactt tatattgttc ttgtaagctt     3120

taactatatc tctctttaaa atgcaaaata atgtcttaag attcaaagtc tgtattttta     3180

aagcatggct ttggctttgc aaaataaaaa atgtgttttg tacatgaa                  3228


<210>  662
<211>  3136
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Synthetic nucleotide

<400>  662
gcttttttct taatgactgc tagaagctgc atcttattga cagatggtca tcacattggt       60

gagctggagt catcagattg tggggcccgg agtgaggctg aagggagtgg atcagagcac      120

tgcctgagag tcacctctac tttcctgcta ccgctgcctg tgagctgaag gggctgaacc      180

atacactcct ttttctacaa ccagcttgca ttttttctgc ccacaatgag cggggaatca      240

atgaatttca gcgatgtttt cgactccagt gaagattatt ttgtgtcagt caatacttca      300

tattactcag ttgattctga gatgttactg tgctccttgc aggaggtcag gcagttctcc      360

aggctatttg taccgattgc ctactccttg atctgtgtct ttggcctcct ggggaatatt      420

ctggtggtga tcacctttgc tttttataag aaggccaggt ctatgacaga cgtctatctc      480

ttgaacatgg ccattgcaga catcctcttt gttcttactc tcccattctg ggcagtgagt      540

catgccaccg gtgcgtgggt tttcagcaat gccacgtgca agttgctaaa aggcatctat      600

gccatcaact ttaactgcgg gatgctgctc ctgacttgca ttagcatgga ccggtacatc      660

gccattgtac aggcgactaa gtcattccgg ctccgatcca gaacactacc gcgcagcaaa      720

atcatctgcc ttgttgtgtg ggggctgtca gtcatcatct ccagctcaac ttttgtcttc      780

aaccaaaaat acaacaccca aggcagcgat gtctgtgaac ccaagtacca gactgtctcg      840

gagcccatca ggtggaagct gctgatgttg gggcttgagc tactctttgg tttctttatc      900

cctttgatgt tcatgatatt ttgttacacg ttcattgtca aaaccttggt gcaagctcag      960

aattctaaaa ggcacaaagc catccgtgta atcatagctg tggtgcttgt gtttctggct     1020

tgtcagattc ctcataacat ggtcctgctt gtgacggctg caaatttggg taaaatgaac     1080

cgatcctgcc agagcgaaaa gctaattggc tatacgaaaa ctgtcacaga agtcctggct     1140

ttcctgcact gctgcctgaa ccctgtgctc tacgctttta ttgggcagaa gttcagaaac     1200

tactttctga agatcttgaa ggacctgtgg tgtgtgagaa ggaagtacaa gtcctcaggc     1260

ttctcctgtg ccgggaggta ctcagaaaac atttctcggc agaccagtga gaccgcagat     1320

aacgacaatg cgtcgtcctt cactatgtga tagaaagctg agtctcccta aggcatgtgt     1380

gaaacatact catagatgtt atgcaaaaaa aagtctatgg ccaggtatgc atggaaaatg     1440

tgggaattaa gcaaaatcaa gcaagcctct ctcctgcggg acttaacgtg ctcatgggct     1500

gtgtgatctc ttcagggtgg ggtggtctct gataggtagc attttccagc actttgcaag     1560

gaatgttttg tagctctagg gtatatatcc gcctggcatt tcacaaaaca gcctttggga     1620

aatgctgaat taaagtgaat tgttgacaaa tgtaaacatt ttcagaaata ttcatgaagc     1680

ggtcacagat cacagtgtct tttggttaca gcacaaaatg atggcagtgg tttgaaaaac     1740

taaaacagaa aaaaaaatgg aagccaacac atcactcatt ttaggcaaat gtttaaacat     1800

ttttatctat cagaatgttt attgttgctg gttataagca gcaggattgg ccggctagtg     1860

tttcctctca tttccctttg atacagtcaa caagcctgac cctgtaaaat ggaggtggaa     1920

agacaagctc aagtgttcac aacctggaag tgcttcggga agaaggggac aatggcagaa     1980

caggtgttgg tgacaattgt caccaattgg ataaagcagc tcaggttgta gtgggccatt     2040

aggaaactgt cggtttgctt tgatttccct gggagctgtt ctctgtcgtg agtgtctctt     2100

gtctaaacgt ccattaagct gagagtgcta tgaagacagg atctagaata atcttgctca     2160

cagctgtgct ctgagtgcct agcggagttc cagcaaacaa aatggactca agagagattt     2220

gattaatgaa tcgtaatgaa gttggggttt attgtacagt ttaaaatgtt agatgttttt     2280

aattttttaa ataaatggaa tacttttttt ttttttttaa agaaagcaac tttactgaga     2340

caatgtagaa agaagttttg ttccgtttct ttaatgtggt tgaagagcaa tgtgtggctg     2400

aagacttttg ttatgaggag ctgcagatta gctaggggac agctggaatt atgctggctt     2460

ctgataatta ttttaaaggg gtctgaaatt tgtgatggaa tcagatttta acagctctct     2520

tcaatgacat agaaagttca tggaactcat gtttttaaag ggctatgtaa atatatgaac     2580

attagaaaaa tagcaacttg tgttacaaaa atacaaacac atgttaggaa ggtactgtca     2640

tgggctaggc atggtggctc acacctgtaa tcccagcatt ttgggaagct aagatgggtg     2700

gatcacttga ggtcaggagt ttgagaccag cctggccaac atggcgaaac ccctctctac     2760

taaaaataca aaaatttgcc aggcgtggtg gcgggtgcct gtaatcccag ctacttggga     2820

ggctgaggca agagaatcgc ttgaacccag gaggcagagg ttgcagtgag ccgagatcgt     2880

gccattgcac tccagcctgg gtgacaaagc gagactccat ctcaaaaaaa aaaaaaaaaa     2940

aaaaggaaag aactgtcatg taaacatacc aacatgttta aacctgacaa tggtgttatt     3000

tgaaacttta tattgttctt gtaagcttta actatatctc tctttaaaat gcaaaataat     3060

gtcttaagat tcaaagtctg tatttttaaa gcatggcttt ggctttgcaa aataaaaaat     3120

gtgttttgta catgaa                                                     3136


<210>  663
<211>  2173
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Synthetic nucleotide

<400>  663
agacaggggt agtgcgaggc cgggcacagc cttcctgtgt ggttttaccg cccagagagc       60

gtcatggacc tggggaaacc aatgaaaagc gtgctggtgg tggctctcct tgtcattttc      120

caggtatgcc tgtgtcaaga tgaggtcacg gacgattaca tcggagacaa caccacagtg      180

gactacactt tgttcgagtc tttgtgctcc aagaaggacg tgcggaactt taaagcctgg      240

ttcctcccta tcatgtactc catcatttgt ttcgtgggcc tactgggcaa tgggctggtc      300

gtgttgacct atatctattt caagaggctc aagaccatga ccgataccta cctgctcaac      360

ctggcggtgg cagacatcct cttcctcctg acccttccct tctgggccta cagcgcggcc      420

aagtcctggg tcttcggtgt ccacttttgc aagctcatct ttgccatcta caagatgagc      480

ttcttcagtg gcatgctcct acttctttgc atcagcattg accgctacgt ggccatcgtc      540

caggctgtct cagctcaccg ccaccgtgcc cgcgtccttc tcatcagcaa gctgtcctgt      600

gtgggcatct ggatactagc cacagtgctc tccatcccag agctcctgta cagtgacctc      660

cagaggagca gcagtgagca agcgatgcga tgctctctca tcacagagca tgtggaggcc      720

tttatcacca tccaggtggc ccagatggtg atcggctttc tggtccccct gctggccatg      780

agcttctgtt accttgtcat catccgcacc ctgctccagg cacgcaactt tgagcgcaac      840

aaggccatca aggtgatcat cgctgtggtc gtggtcttca tagtcttcca gctgccctac      900

aatggggtgg tcctggccca gacggtggcc aacttcaaca tcaccagtag cacctgtgag      960

ctcagtaagc aactcaacat cgcctacgac gtcacctaca gcctggcctg cgtccgctgc     1020

tgcgtcaacc ctttcttgta cgccttcatc ggcgtcaagt tccgcaacga tctcttcaag     1080

ctcttcaagg acctgggctg cctcagccag gagcagctcc ggcagtggtc ttcctgtcgg     1140

cacatccggc gctcctccat gagtgtggag gccgagacca ccaccacctt ctccccatag     1200

gcgactcttc tgcctggact agagggacct ctcccagggt ccctggggtg gggataggga     1260

gcagatgcaa tgactcagga catccccccg ccaaaagctg ctcagggaaa agcagctctc     1320

ccctcagagt gcaagcccct gctccagaag atagcttcac cccaatccca gctacctcaa     1380

ccaatgccaa aaaaagacag ggctgataag ctaacaccag acagacaaca ctgggaaaca     1440

gaggctattg tcccctaaac caaaaactga aagtgaaagt ccagaaactg ttcccacctg     1500

ctggagtgaa ggggccaagg agggtgagtg caaggggcgt gggagtggcc tgaagagtcc     1560

tctgaatgaa ccttctggcc tcccacagac tcaaatgctc agaccagctc ttccgaaaac     1620

caggccttat ctccaagacc agagatagtg gggagacttc ttggcttggt gaggaaaagc     1680

ggacatcagc tggtcaaaca aactctctga acccctccct ccatcgtttt cttcactgtc     1740

ctccaagcca gcgggaatgg cagctgccac gccgccctaa aagcacactc atcccctcac     1800

ttgccgcgtc gccctcccag gctctcaaca ggggagagtg tggtgtttcc tgcaggccag     1860

gccagctgcc tccgcgtgat caaagccaca ctctgggctc cagagtgggg atgacatgca     1920

ctcagctctt ggctccactg ggatgggagg agaggacaag ggaaatgtca ggggcgggga     1980

gggtgacagt ggccgcccaa ggcccacgag cttgttcttt gttctttgtc acagggactg     2040

aaaacctctc ctcatgttct gctttcgatt cgttaagaga gcaacatttt acccacacac     2100

agataaagtt ttcccttgag gaaacaacag ctttaaaaga aaaagaaaaa aaaagtcttt     2160

ggtaaatggc aaa                                                        2173


<210>  664
<211>  2123
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Synthetic nucleotide

<400>  664
agacaggggt agtgcgaggc cgggcacagc cttcctgtgt ggttttaccg cccagagagc       60

gtcatggacc tgggtatgcc tgtgtcaaga tgaggtcacg gacgattaca tcggagacaa      120

caccacagtg gactacactt tgttcgagtc tttgtgctcc aagaaggacg tgcggaactt      180

taaagcctgg ttcctcccta tcatgtactc catcatttgt ttcgtgggcc tactgggcaa      240

tgggctggtc gtgttgacct atatctattt caagaggctc aagaccatga ccgataccta      300

cctgctcaac ctggcggtgg cagacatcct cttcctcctg acccttccct tctgggccta      360

cagcgcggcc aagtcctggg tcttcggtgt ccacttttgc aagctcatct ttgccatcta      420

caagatgagc ttcttcagtg gcatgctcct acttctttgc atcagcattg accgctacgt      480

ggccatcgtc caggctgtct cagctcaccg ccaccgtgcc cgcgtccttc tcatcagcaa      540

gctgtcctgt gtgggcatct ggatactagc cacagtgctc tccatcccag agctcctgta      600

cagtgacctc cagaggagca gcagtgagca agcgatgcga tgctctctca tcacagagca      660

tgtggaggcc tttatcacca tccaggtggc ccagatggtg atcggctttc tggtccccct      720

gctggccatg agcttctgtt accttgtcat catccgcacc ctgctccagg cacgcaactt      780

tgagcgcaac aaggccatca aggtgatcat cgctgtggtc gtggtcttca tagtcttcca      840

gctgccctac aatggggtgg tcctggccca gacggtggcc aacttcaaca tcaccagtag      900

cacctgtgag ctcagtaagc aactcaacat cgcctacgac gtcacctaca gcctggcctg      960

cgtccgctgc tgcgtcaacc ctttcttgta cgccttcatc ggcgtcaagt tccgcaacga     1020

tctcttcaag ctcttcaagg acctgggctg cctcagccag gagcagctcc ggcagtggtc     1080

ttcctgtcgg cacatccggc gctcctccat gagtgtggag gccgagacca ccaccacctt     1140

ctccccatag gcgactcttc tgcctggact agagggacct ctcccagggt ccctggggtg     1200

gggataggga gcagatgcaa tgactcagga catccccccg ccaaaagctg ctcagggaaa     1260

agcagctctc ccctcagagt gcaagcccct gctccagaag atagcttcac cccaatccca     1320

gctacctcaa ccaatgccaa aaaaagacag ggctgataag ctaacaccag acagacaaca     1380

ctgggaaaca gaggctattg tcccctaaac caaaaactga aagtgaaagt ccagaaactg     1440

ttcccacctg ctggagtgaa ggggccaagg agggtgagtg caaggggcgt gggagtggcc     1500

tgaagagtcc tctgaatgaa ccttctggcc tcccacagac tcaaatgctc agaccagctc     1560

ttccgaaaac caggccttat ctccaagacc agagatagtg gggagacttc ttggcttggt     1620

gaggaaaagc ggacatcagc tggtcaaaca aactctctga acccctccct ccatcgtttt     1680

cttcactgtc ctccaagcca gcgggaatgg cagctgccac gccgccctaa aagcacactc     1740

atcccctcac ttgccgcgtc gccctcccag gctctcaaca ggggagagtg tggtgtttcc     1800

tgcaggccag gccagctgcc tccgcgtgat caaagccaca ctctgggctc cagagtgggg     1860

atgacatgca ctcagctctt ggctccactg ggatgggagg agaggacaag ggaaatgtca     1920

ggggcgggga gggtgacagt ggccgcccaa ggcccacgag cttgttcttt gttctttgtc     1980

acagggactg aaaacctctc ctcatgttct gctttcgatt cgttaagaga gcaacatttt     2040

acccacacac agataaagtt ttcccttgag gaaacaacag ctttaaaaga aaaagaaaaa     2100

aaaagtcttt ggtaaatggc aaa                                             2123


<210>  665
<211>  2435
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Synthetic nucleotide

<400>  665
ctctagatga gtcagtggag ggcgggtgga gcgttgaacc gtgaagagtg tggttgggcg       60

taaacgtgga cttaaactca ggagctaagg ggtaattcag tgaaaaaggg gaatgagcgg      120

tggggagctc tgttgcaaca gggtccaatc gcagcaggac tacaaatgcc cgagcgcagg      180

ctgggaacga ggggacagcg gctgcctgtc cccagaatag aaaatgcagc taggaagccc      240

tctttgagtg gacagcggag gactggactg ccaggccaag catcaggggc ttcatcctca      300

gggccggtta gagcccctga ggatttagga ggaagggaaa ccaatgaaaa gcgtgctggt      360

ggtggctctc cttgtcattt tccaggtatg cctgtgtcaa gatgaggtca cggacgatta      420

catcggagac aacaccacag tggactacac tttgttcgag tctttgtgct ccaagaagga      480

cgtgcggaac tttaaagcct ggttcctccc tatcatgtac tccatcattt gtttcgtggg      540

cctactgggc aatgggctgg tcgtgttgac ctatatctat ttcaagaggc tcaagaccat      600

gaccgatacc tacctgctca acctggcggt ggcagacatc ctcttcctcc tgacccttcc      660

cttctgggcc tacagcgcgg ccaagtcctg ggtcttcggt gtccactttt gcaagctcat      720

ctttgccatc tacaagatga gcttcttcag tggcatgctc ctacttcttt gcatcagcat      780

tgaccgctac gtggccatcg tccaggctgt ctcagctcac cgccaccgtg cccgcgtcct      840

tctcatcagc aagctgtcct gtgtgggcat ctggatacta gccacagtgc tctccatccc      900

agagctcctg tacagtgacc tccagaggag cagcagtgag caagcgatgc gatgctctct      960

catcacagag catgtggagg cctttatcac catccaggtg gcccagatgg tgatcggctt     1020

tctggtcccc ctgctggcca tgagcttctg ttaccttgtc atcatccgca ccctgctcca     1080

ggcacgcaac tttgagcgca acaaggccat caaggtgatc atcgctgtgg tcgtggtctt     1140

catagtcttc cagctgccct acaatggggt ggtcctggcc cagacggtgg ccaacttcaa     1200

catcaccagt agcacctgtg agctcagtaa gcaactcaac atcgcctacg acgtcaccta     1260

cagcctggcc tgcgtccgct gctgcgtcaa ccctttcttg tacgccttca tcggcgtcaa     1320

gttccgcaac gatctcttca agctcttcaa ggacctgggc tgcctcagcc aggagcagct     1380

ccggcagtgg tcttcctgtc ggcacatccg gcgctcctcc atgagtgtgg aggccgagac     1440

caccaccacc ttctccccat aggcgactct tctgcctgga ctagagggac ctctcccagg     1500

gtccctgggg tggggatagg gagcagatgc aatgactcag gacatccccc cgccaaaagc     1560

tgctcaggga aaagcagctc tcccctcaga gtgcaagccc ctgctccaga agatagcttc     1620

accccaatcc cagctacctc aaccaatgcc aaaaaaagac agggctgata agctaacacc     1680

agacagacaa cactgggaaa cagaggctat tgtcccctaa accaaaaact gaaagtgaaa     1740

gtccagaaac tgttcccacc tgctggagtg aaggggccaa ggagggtgag tgcaaggggc     1800

gtgggagtgg cctgaagagt cctctgaatg aaccttctgg cctcccacag actcaaatgc     1860

tcagaccagc tcttccgaaa accaggcctt atctccaaga ccagagatag tggggagact     1920

tcttggcttg gtgaggaaaa gcggacatca gctggtcaaa caaactctct gaacccctcc     1980

ctccatcgtt ttcttcactg tcctccaagc cagcgggaat ggcagctgcc acgccgccct     2040

aaaagcacac tcatcccctc acttgccgcg tcgccctccc aggctctcaa caggggagag     2100

tgtggtgttt cctgcaggcc aggccagctg cctccgcgtg atcaaagcca cactctgggc     2160

tccagagtgg ggatgacatg cactcagctc ttggctccac tgggatggga ggagaggaca     2220

agggaaatgt caggggcggg gagggtgaca gtggccgccc aaggcccacg agcttgttct     2280

ttgttctttg tcacagggac tgaaaacctc tcctcatgtt ctgctttcga ttcgttaaga     2340

gagcaacatt ttacccacac acagataaag ttttcccttg aggaaacaac agctttaaaa     2400

gaaaaagaaa aaaaaagtct ttggtaaatg gcaaa                                2435


<210>  666
<211>  2226
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Synthetic nucleotide

<400>  666
ctctagatga gtcagtggag ggcgggtgga gcgttgaacc gtgaagagtg tggttgggcg       60

taaacgtgga cttaaactca ggagctaagg gggaaaccaa tgaaaagcgt gctggtggtg      120

gctctccttg tcattttcca ggtatgcctg tgtcaagatg aggtcacgga cgattacatc      180

ggagacaaca ccacagtgga ctacactttg ttcgagtctt tgtgctccaa gaaggacgtg      240

cggaacttta aagcctggtt cctccctatc atgtactcca tcatttgttt cgtgggccta      300

ctgggcaatg ggctggtcgt gttgacctat atctatttca agaggctcaa gaccatgacc      360

gatacctacc tgctcaacct ggcggtggca gacatcctct tcctcctgac ccttcccttc      420

tgggcctaca gcgcggccaa gtcctgggtc ttcggtgtcc acttttgcaa gctcatcttt      480

gccatctaca agatgagctt cttcagtggc atgctcctac ttctttgcat cagcattgac      540

cgctacgtgg ccatcgtcca ggctgtctca gctcaccgcc accgtgcccg cgtccttctc      600

atcagcaagc tgtcctgtgt gggcatctgg atactagcca cagtgctctc catcccagag      660

ctcctgtaca gtgacctcca gaggagcagc agtgagcaag cgatgcgatg ctctctcatc      720

acagagcatg tggaggcctt tatcaccatc caggtggccc agatggtgat cggctttctg      780

gtccccctgc tggccatgag cttctgttac cttgtcatca tccgcaccct gctccaggca      840

cgcaactttg agcgcaacaa ggccatcaag gtgatcatcg ctgtggtcgt ggtcttcata      900

gtcttccagc tgccctacaa tggggtggtc ctggcccaga cggtggccaa cttcaacatc      960

accagtagca cctgtgagct cagtaagcaa ctcaacatcg cctacgacgt cacctacagc     1020

ctggcctgcg tccgctgctg cgtcaaccct ttcttgtacg ccttcatcgg cgtcaagttc     1080

cgcaacgatc tcttcaagct cttcaaggac ctgggctgcc tcagccagga gcagctccgg     1140

cagtggtctt cctgtcggca catccggcgc tcctccatga gtgtggaggc cgagaccacc     1200

accaccttct ccccataggc gactcttctg cctggactag agggacctct cccagggtcc     1260

ctggggtggg gatagggagc agatgcaatg actcaggaca tccccccgcc aaaagctgct     1320

cagggaaaag cagctctccc ctcagagtgc aagcccctgc tccagaagat agcttcaccc     1380

caatcccagc tacctcaacc aatgccaaaa aaagacaggg ctgataagct aacaccagac     1440

agacaacact gggaaacaga ggctattgtc ccctaaacca aaaactgaaa gtgaaagtcc     1500

agaaactgtt cccacctgct ggagtgaagg ggccaaggag ggtgagtgca aggggcgtgg     1560

gagtggcctg aagagtcctc tgaatgaacc ttctggcctc ccacagactc aaatgctcag     1620

accagctctt ccgaaaacca ggccttatct ccaagaccag agatagtggg gagacttctt     1680

ggcttggtga ggaaaagcgg acatcagctg gtcaaacaaa ctctctgaac ccctccctcc     1740

atcgttttct tcactgtcct ccaagccagc gggaatggca gctgccacgc cgccctaaaa     1800

gcacactcat cccctcactt gccgcgtcgc cctcccaggc tctcaacagg ggagagtgtg     1860

gtgtttcctg caggccaggc cagctgcctc cgcgtgatca aagccacact ctgggctcca     1920

gagtggggat gacatgcact cagctcttgg ctccactggg atgggaggag aggacaaggg     1980

aaatgtcagg ggcggggagg gtgacagtgg ccgcccaagg cccacgagct tgttctttgt     2040

tctttgtcac agggactgaa aacctctcct catgttctgc tttcgattcg ttaagagagc     2100

aacattttac ccacacacag ataaagtttt cccttgagga aacaacagct ttaaaagaaa     2160

aagaaaaaaa aagtctttgg taaatggcaa agaaaaagaa aaaaaaagtc tttggtaaat     2220

ggcaaa                                                                2226


<210>  667
<211>  2281
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Synthetic nucleotide

<400>  667
aggagaaggt gccttaaaca ggttcccacg catttcctgg cgctattgag cttggagctg       60

ccaagggcct gccttcactt gtggcatcgc agttactgac tctccagtgg gccaggccct      120

acctagctgg gacctgaggg tcaggatacg ggaagagggc tactgccgcc ctgacttgta      180

gggaaaccaa tgaaaagcgt gctggtggtg gctctccttg tcattttcca ggtatgcctg      240

tgtcaagatg aggtcacgga cgattacatc ggagacaaca ccacagtgga ctacactttg      300

ttcgagtctt tgtgctccaa gaaggacgtg cggaacttta aagcctggtt cctccctatc      360

atgtactcca tcatttgttt cgtgggccta ctgggcaatg ggctggtcgt gttgacctat      420

atctatttca agaggctcaa gaccatgacc gatacctacc tgctcaacct ggcggtggca      480

gacatcctct tcctcctgac ccttcccttc tgggcctaca gcgcggccaa gtcctgggtc      540

ttcggtgtcc acttttgcaa gctcatcttt gccatctaca agatgagctt cttcagtggc      600

atgctcctac ttctttgcat cagcattgac cgctacgtgg ccatcgtcca ggctgtctca      660

gctcaccgcc accgtgcccg cgtccttctc atcagcaagc tgtcctgtgt gggcatctgg      720

atactagcca cagtgctctc catcccagag ctcctgtaca gtgacctcca gaggagcagc      780

agtgagcaag cgatgcgatg ctctctcatc acagagcatg tggaggcctt tatcaccatc      840

caggtggccc agatggtgat cggctttctg gtccccctgc tggccatgag cttctgttac      900

cttgtcatca tccgcaccct gctccaggca cgcaactttg agcgcaacaa ggccatcaag      960

gtgatcatcg ctgtggtcgt ggtcttcata gtcttccagc tgccctacaa tggggtggtc     1020

ctggcccaga cggtggccaa cttcaacatc accagtagca cctgtgagct cagtaagcaa     1080

ctcaacatcg cctacgacgt cacctacagc ctggcctgcg tccgctgctg cgtcaaccct     1140

ttcttgtacg ccttcatcgg cgtcaagttc cgcaacgatc tcttcaagct cttcaaggac     1200

ctgggctgcc tcagccagga gcagctccgg cagtggtctt cctgtcggca catccggcgc     1260

tcctccatga gtgtggaggc cgagaccacc accaccttct ccccataggc gactcttctg     1320

cctggactag agggacctct cccagggtcc ctggggtggg gatagggagc agatgcaatg     1380

actcaggaca tccccccgcc aaaagctgct cagggaaaag cagctctccc ctcagagtgc     1440

aagcccctgc tccagaagat agcttcaccc caatcccagc tacctcaacc aatgccaaaa     1500

aaagacaggg ctgataagct aacaccagac agacaacact gggaaacaga ggctattgtc     1560

ccctaaacca aaaactgaaa gtgaaagtcc agaaactgtt cccacctgct ggagtgaagg     1620

ggccaaggag ggtgagtgca aggggcgtgg gagtggcctg aagagtcctc tgaatgaacc     1680

ttctggcctc ccacagactc aaatgctcag accagctctt ccgaaaacca ggccttatct     1740

ccaagaccag agatagtggg gagacttctt ggcttggtga ggaaaagcgg acatcagctg     1800

gtcaaacaaa ctctctgaac ccctccctcc atcgttttct tcactgtcct ccaagccagc     1860

gggaatggca gctgccacgc cgccctaaaa gcacactcat cccctcactt gccgcgtcgc     1920

cctcccaggc tctcaacagg ggagagtgtg gtgtttcctg caggccaggc cagctgcctc     1980

cgcgtgatca aagccacact ctgggctcca gagtggggat gacatgcact cagctcttgg     2040

ctccactggg atgggaggag aggacaaggg aaatgtcagg ggcggggagg gtgacagtgg     2100

ccgcccaagg cccacgagct tgttctttgt tctttgtcac agggactgaa aacctctcct     2160

catgttctgc tttcgattcg ttaagagagc aacattttac ccacacacag ataaagtttt     2220

cccttgagga aacaacagct ttaaaagaaa aagaaaaaaa aagtctttgg taaatggcaa     2280

a                                                                     2281


<210>  668
<211>  1484
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Synthetic nucleotide

<400>  668
gtagtgggag gatacctcca gagaggctgc tgctcattga gctgcactca catgaggata       60

cagactttgt gaagaaggaa ttggcaacac tgaaacctcc agaacaaagg ctgtcactaa      120

ggtcccgctg ccttgatgga ttatacactt gacctcagtg tgacaacagt gaccgactac      180

tactaccctg atatcttctc aagcccctgt gatgcggaac ttattcagac aaatggcaag      240

ttgctccttg ctgtctttta ttgcctcctg tttgtattca gtcttctggg aaacagcctg      300

gtcatcctgg tccttgtggt ctgcaagaag ctgaggagca tcacagatgt atacctcttg      360

aacctggccc tgtctgacct gctttttgtc ttctccttcc cctttcagac ctactatctg      420

ctggaccagt gggtgtttgg gactgtaatg tgcaaagtgg tgtctggctt ttattacatt      480

ggcttctaca gcagcatgtt tttcatcacc ctcatgagtg tggacaggta cctggctgtt      540

gtccatgccg tgtatgccct aaaggtgagg acgatcagga tgggcacaac gctgtgcctg      600

gcagtatggc taaccgccat tatggctacc atcccattgc tagtgtttta ccaagtggcc      660

tctgaagatg gtgttctaca gtgttattca ttttacaatc aacagacttt gaagtggaag      720

atcttcacca acttcaaaat gaacatttta ggcttgttga tcccattcac catctttatg      780

ttctgctaca ttaaaatcct gcaccagctg aagaggtgtc aaaaccacaa caagaccaag      840

gccatcaggt tggtgctcat tgtggtcatt gcatctttac ttttctgggt cccattcaac      900

gtggttcttt tcctcacttc cttgcacagt atgcacatct tggatggatg tagcataagc      960

caacagctga cttatgccac ccatgtcaca gaaatcattt cctttactca ctgctgtgtg     1020

aaccctgtta tctatgcttt tgttggggag aagttcaaga aacacctctc agaaatattt     1080

cagaaaagtt gcagccaaat cttcaactac ctaggaagac aaatgcctag ggagagctgt     1140

gaaaagtcat catcctgcca gcagcactcc tcccgttcct ccagcgtaga ctacattttg     1200

tgaggatcaa tgaagactaa atataaaaaa cattttcttg aatggcatgc tagtagcagt     1260

gagcaaaggt gtgggtgtga aaggtttcca aaaaaagttc agcatgaagg atgccatata     1320

tgttgttgcc aacacttgga acacaatgac taaagacata gttgtgcatg cctggcacaa     1380

catcaagcct gtgattgtgt ttattgatga tgttgaacaa gtggtaactt taaaggattc     1440

tgtatgccaa gtgaaaaaaa aagatgtctg acctccttac atat                      1484


<210>  669
<211>  6203
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Synthetic nucleotide

<400>  669
aatgaaagac cccacctgta ggtttggcaa gctagcttaa gtaacgccat tttgcaaggc       60

atggaaaata cataactgag aatagagaag ttcagatcaa ggttaggaac agagagacag      120

cagaatatgg gccaaacagg atatctgtgg taagcagttc ctgccccggc tcagggccaa      180

gaacagatgg tccccagatg cggtcccgcc ctcagcagtt tctagagaac catcagatgt      240

ttccagggtg ccccaaggac ctgaaatgac cctgtgcctt atttgaacta accaatcagt      300

tcgcttctcg cttctgttcg cgcgcttctg ctccccgagc tcaataaaag agcccacaac      360

ccctcactcg gcgcgccagt cctccgatag actgcgtcgc ccgggtaccc gtattcccaa      420

taaagcctct tgctgtttgc atccgaatcg tggactcgct gatccttggg agggtctcct      480

cagattgatt gactgcccac ctcgggggtc tttcatttgg aggttccacc gagatttgga      540

gacccctgcc cagggaccac cgaccccccc gccgggaggt aagctggcca gcggtcgttt      600

cgtgtctgtc tctgtctttg tgcgtgtttg tgccggcatc taatgtttgc gcctgcgtct      660

gtactagtta gctaactagc tctgtatctg gcggacccgt ggtggaactg acgagttctg      720

aacacccggc cgcaaccctg ggagacgtcc cagggacttt gggggccgtt tttgtggccc      780

gacctgagga agggagtcga tgtggaatcc gaccccgtca ggatatgtgg ttctggtagg      840

agacgagaac ctaaaacagt tcccgcctcc gtctgaattt ttgctttcgg tttggaaccg      900

aagccgcgcg tcttgtctgc tgcagcgctg cagcatcgtt ctgtgttgtc tctgtctgac      960

tgtgtttctg tatttgtctg aaaattaggg ccagactgtt accactccct taagtttgac     1020

cttaggtcac tggaaagatg tcgagcggat cgctcacaac cagtcggtag atgtcaagaa     1080

gagacgttgg gttaccttct gctctgcaga atggccaacc tttaacgtcg gatggccgcg     1140

agacggcacc tttaaccgag acctcatcac ccaggttaag atcaaggtct tttcacctgg     1200

cccgcatgga cacccagacc aggtccccta catcgtgacc tgggaagcct tggcttttga     1260

cccccctccc tgggtcaagc cctttgtaca ccctaagcct ccgcctcctc ttcctccatc     1320

cgccccgtct ctcccccttg aacctcctcg ttcgaccccg cctcgatcct ccctttatcc     1380

agccctcact ccttctctag gcgccggaat tccaagtttg tacaaaaaag caggctgcca     1440

ccatgtcaaa tattacagat ccacagatgt gggattttga tgatctaaat ttcactggca     1500

tgccacctgc agatgaagat tacagcccct gtatgctaga aactgagaca ctcaacaagt     1560

atgttgtgat catcgcctat gccctagtgt tcctgctgag cctgctggga aactccctgg     1620

tgatgctggt catcttatac agcagggtcg gccgctccgt cactgatgtc tacctgctga     1680

acctggcctt ggccgaccta ctctttgccc tgaccttgcc catctgggcc gcctccaagg     1740

tgaatggctg gatttttggc acattcctgt gcaaggtggt ctcactcctg aaggaagtca     1800

acttctacag tggcatcctg ctgttggcct gcatcagtgt ggaccgttac ctggccattg     1860

tccatgccac acgcacactg acccagaagc gtcacttggt caagtttgtt tgtcttggct     1920

gctggggact gtctatgaat ctgtccctgc ccttcttcct tttccgccag gcttaccatc     1980

caaacaattc cagtccagtt tgctatgagg tcctgggaaa tgacacagca aaatggcgga     2040

tggtgttgcg gatcctgcct cacacctttg gcttcatcgt gccgctgttt gtcatgctgt     2100

tctgctatgg attcaccctg cgtacactgt ttaaggccca catggggcag aagcaccgag     2160

ccatgagggt catctttgct gtcgtcctca tcttcctgct ttgctggctg ccctacaacc     2220

tggtcctgct ggcagacacc ctcatgagga cccaggtgat ccaggagagc tgtgagcgcc     2280

gcaacaacat cggccgggcc ctggatgcca ctgagattct gggatttctc catagctgcc     2340

tcaaccccat catctacgcc ttcatcggcc aaaattttcg ccatggattc ctcaagatcc     2400

tggctatgca tggcctggtc agcaaggagt tcttggcacg tcatcgtgtt acctcctaca     2460

cttcttcgtc tgtcaatgtc tcttccaacc tctgaaccca gctttcttgt acaaagtggc     2520

tcgagagatc cgtcgacctg cagccaagct tatcgataaa ataaaagatt ttatttagtc     2580

tccagaaaaa ggggggaatg aaagacccca cctgtaggtt tggcaagcta gcttaagtaa     2640

cgccattttg caaggcatgg aaaatacata actgagaata gagaagttca gatcaaggtt     2700

aggaacagag agacagcaga atatgggcca aacaggatat ctgtggtaag cagttcctgc     2760

cccggctcag ggccaagaac agatggtccc cagatgcggt cccgccctca gcagtttcta     2820

gagaaccatc agatgtttcc agggtgcccc aaggacctga aatgaccctg tgccttattt     2880

gaactaacca atcagttcgc ttctcgcttc tgttcgcgcg cttctgctcc ccgagctcaa     2940

taaaagagcc cacaacccct cactcggcgc gccagtcctc cgatagactg cgtcgcccgg     3000

gtacccgtgt atccaataaa ccctcttgca gttgcatccg acttgtggtc tcgctgttcc     3060

ttgggagggt ctcctctgag tgattgacta cccgtcagcg ggggtctttc atgggtaaca     3120

gtttcttgaa gttggagaac aacattctga gggtaggagt cgaatattaa gtaatcctga     3180

ctcaattagc cactgttttg aatccacata ctccaatact cctgaaatag ttcattatgg     3240

acagcgcaga aagagctggg gagaattgtg aaattgttat ccgctcacaa ttccacacaa     3300

catacgagcc ggaagcataa agtgtaaagc ctggggtgcc taatgagtga gctaactcac     3360

attaattgcg ttgcgctcac tgcccgcttt ccagtcggga aacctgtcgt gccagctgca     3420

ttaatgaatc ggccaacgcg cggggagagg cggtttgcgt attgggcgct cttccgcttc     3480

ctcgctcact gactcgctgc gctcggtcgt tcggctgcgg cgagcggtat cagctcactc     3540

aaaggcggta atacggttat ccacagaatc aggggataac gcaggaaaga acatgtgagc     3600

aaaaggccag caaaaggcca ggaaccgtaa aaaggccgcg ttgctggcgt ttttccatag     3660

gctccgcccc cctgacgagc atcacaaaaa tcgacgctca agtcagaggt ggcgaaaccc     3720

gacaggacta taaagatacc aggcgtttcc ccctggaagc tccctcgtgc gctctcctgt     3780

tccgaccctg ccgcttaccg gatacctgtc cgcctttctc ccttcgggaa gcgtggcgct     3840

ttctcatagc tcacgctgta ggtatctcag ttcggtgtag gtcgttcgct ccaagctggg     3900

ctgtgtgcac gaaccccccg ttcagcccga ccgctgcgcc ttatccggta actatcgtct     3960

tgagtccaac ccggtaagac acgacttatc gccactggca gcagccactg gtaacaggat     4020

tagcagagcg aggtatgtag gcggtgctac agagttcttg aagtggtggc ctaactacgg     4080

ctacactaga agaacagtat ttggtatctg cgctctgctg aagccagtta ccttcggaaa     4140

aagagttggt agctcttgat ccggcaaaca aaccaccgct ggtagcggtg gtttttttgt     4200

ttgcaagcag cagattacgc gcagaaaaaa aggatctcaa gaagatcctt tgatcttttc     4260

tacggggtct gacgctcagt ggaacgaaaa ctcacgttaa gggattttgg tcatgagatt     4320

atcaaaaagg atcttcacct agatcctttt aaattaaaaa tgaagtttta aatcaatcta     4380

aagtatatat gagtaaactt ggtctgacag ttaccaatgc ttaatcagtg aggcacctat     4440

ctcagcgatc tgtctatttc gttcatccat agttgcctga ctccccgtcg tgtagataac     4500

tacgatacgg gagggcttac catctggccc cagtgctgca atgataccgc gagacccacg     4560

ctcaccggct ccagatttat cagcaataaa ccagccagcc ggaagggccg agcgcagaag     4620

tggtcctgca actttatccg cctccatcca gtctattaat tgttgccggg aagctagagt     4680

aagtagttcg ccagttaata gtttgcgcaa cgttgttgcc attgctacag gcatcgtggt     4740

gtcacgctcg tcgtttggta tggcttcatt cagctccggt tcccaacgat caaggcgagt     4800

tacatgatcc cccatgttgt gcaaaaaagc ggttagctcc ttcggtcctc cgatcgttgt     4860

cagaagtaag ttggccgcag tgttatcact catggttatg gcagcactgc ataattctct     4920

tactgtcatg ccatccgtaa gatgcttttc tgtgactggt gagtactcaa ccaagtcatt     4980

ctgagaatag tgtatgcggc gaccgagttg ctcttgcccg gcgtcaatac gggataatac     5040

cgcgccacat agcagaactt taaaagtgct catcattgga aaacgttctt cggggcgaaa     5100

actctcaagg atcttaccgc tgttgagatc cagttcgatg taacccactc gtgcacccaa     5160

ctgatcttca gcatctttta ctttcaccag cgtttctggg tgagcaaaaa caggaaggca     5220

aaatgccgca aaaaagggaa taagggcgac acggaaatgt tgaatactca tactcttcct     5280

ttttcaatat tattgaagca tttatcaggg ttattgtctc atgagcggat acatatttga     5340

atgtatttag aaaaataaac aaataggggt tccgcgcaca tttccccgaa aagtgccacc     5400

tgacgtctaa gaaaccatta ttatcatgac attaacctat aaaaataggc gtatcacgag     5460

gccctttcgt ctcgcgcgtt tcggtgatga cggtgaaaac ctctgacaca tgcagctccc     5520

ggagacggtc acagcttgtc tgtaagcgga tgccgggagc agacaagccc gtcagggcgc     5580

gtcagcgggt gttggcgggt gtcggggctg gcttaactat gcggcatcag agcagattgt     5640

actgagagtg caccatatgc ggtgtgaaat accgcacaga tgcgtaagga gaaaataccg     5700

catcaggcgc cattcgccat tcaggctgcg caactgttgg gaagggcgat cggtgcgggc     5760

ctcttcgcta ttacgccagc tggcgaaagg gggatgtgct gcaaggcgat taagttgggt     5820

aacgccaggg ttttcccagt cacgacgttg taaaacgacg gcgcaaggaa tggtgcatgc     5880

aaggagatgg cgcccaacag tcccccggcc acggggcctg ccaccatacc cacgccgaaa     5940

caagcgctca tgagcccgaa gtggcgagcc cgatcttccc catcggtgat gtcggcgata     6000

taggcgccag caaccgcacc tgtggcgccg gtgatgccgg ccacgatgcg tccggcgtag     6060

aggcgattag tccaatttgt taaagacagg atatcagtgg tccaggctct agttttgact     6120

caacaatatc accagctgaa gcctatagag tacgagccat agataaaata aaagatttta     6180

tttagtctcc agaaaaaggg ggg                                             6203


<210>  670
<211>  6218
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Synthetic nucleotide

<400>  670
aatgaaagac cccacctgta ggtttggcaa gctagcttaa gtaacgccat tttgcaaggc       60

atggaaaata cataactgag aatagagaag ttcagatcaa ggttaggaac agagagacag      120

cagaatatgg gccaaacagg atatctgtgg taagcagttc ctgccccggc tcagggccaa      180

gaacagatgg tccccagatg cggtcccgcc ctcagcagtt tctagagaac catcagatgt      240

ttccagggtg ccccaaggac ctgaaatgac cctgtgcctt atttgaacta accaatcagt      300

tcgcttctcg cttctgttcg cgcgcttctg ctccccgagc tcaataaaag agcccacaac      360

ccctcactcg gcgcgccagt cctccgatag actgcgtcgc ccgggtaccc gtattcccaa      420

taaagcctct tgctgtttgc atccgaatcg tggactcgct gatccttggg agggtctcct      480

cagattgatt gactgcccac ctcgggggtc tttcatttgg aggttccacc gagatttgga      540

gacccctgcc cagggaccac cgaccccccc gccgggaggt aagctggcca gcggtcgttt      600

cgtgtctgtc tctgtctttg tgcgtgtttg tgccggcatc taatgtttgc gcctgcgtct      660

gtactagtta gctaactagc tctgtatctg gcggacccgt ggtggaactg acgagttctg      720

aacacccggc cgcaaccctg ggagacgtcc cagggacttt gggggccgtt tttgtggccc      780

gacctgagga agggagtcga tgtggaatcc gaccccgtca ggatatgtgg ttctggtagg      840

agacgagaac ctaaaacagt tcccgcctcc gtctgaattt ttgctttcgg tttggaaccg      900

aagccgcgcg tcttgtctgc tgcagcgctg cagcatcgtt ctgtgttgtc tctgtctgac      960

tgtgtttctg tatttgtctg aaaattaggg ccagactgtt accactccct taagtttgac     1020

cttaggtcac tggaaagatg tcgagcggat cgctcacaac cagtcggtag atgtcaagaa     1080

gagacgttgg gttaccttct gctctgcaga atggccaacc tttaacgtcg gatggccgcg     1140

agacggcacc tttaaccgag acctcatcac ccaggttaag atcaaggtct tttcacctgg     1200

cccgcatgga cacccagacc aggtccccta catcgtgacc tgggaagcct tggcttttga     1260

cccccctccc tgggtcaagc cctttgtaca ccctaagcct ccgcctcctc ttcctccatc     1320

cgccccgtct ctcccccttg aacctcctcg ttcgaccccg cctcgatcct ccctttatcc     1380

agccctcact ccttctctag gcgccggaat tccaagtttg tacaaaaaag caggctgcca     1440

ccatggatta tacacttgac ctcagtgtga caacagtgac cgactactac taccctgata     1500

tcttctcaag cccctgtgat gcggaactta ttcagacaaa tggcaagttg ctccttgctg     1560

tcttttattg cctcctgttt gtattcagtc ttctgggaaa cagcctggtc atcctggtcc     1620

ttgtggtctg caagaagctg aggagcatca cagatgtata cctcttgaac ctggccctgt     1680

ctgacctgct ttttgtcttc tccttcccct ttcagaccta ctatctgctg gaccagtggg     1740

tgtttgggac tgtaatgtgc aaagtggtgt ctggctttta ttacattggc ttctacagca     1800

gcatgttttt catcaccctc atgagtgtgg acaggtacct ggctgttgtc catgccgtgt     1860

atgccctaaa ggtgaggacg atcaggatgg gcacaacgct gtgcctggca gtatggctaa     1920

ccgccattat ggctaccatc ccattgctag tgttttacca agtggcctct gaagatggtg     1980

ttctacagtg ttattcattt tacaatcaac agactttgaa gtggaagatc ttcaccaact     2040

tcaaaatgaa cattttaggc ttgttgatcc cattcaccat ctttatgttc tgctacatta     2100

aaatcctgca ccagctgaag aggtgtcaaa accacaacaa gaccaaggcc atcaggttgg     2160

tgctcattgt ggtcattgca tctttacttt tctgggtccc attcaacgtg gttcttttcc     2220

tcacttcctt gcacagtatg cacatcttgg atggatgtag cataagccaa cagctgactt     2280

atgccaccca tgtcacagaa atcatttcct ttactcactg ctgtgtgaac cctgttatct     2340

atgcttttgt tggggagaag ttcaagaaac acctctcaga aatatttcag aaaagttgca     2400

gccaaatctt caactaccta ggaagacaaa tgcctaggga gagctgtgaa aagtcatcat     2460

cctgccagca gcactcctcc cgttcctcca gcgtagacta cattttgtga acccagcttt     2520

cttgtacaaa gtggctcgag agatccgtcg acctgcagcc aagcttatcg ataaaataaa     2580

agattttatt tagtctccag aaaaaggggg gaatgaaaga ccccacctgt aggtttggca     2640

agctagctta agtaacgcca ttttgcaagg catggaaaat acataactga gaatagagaa     2700

gttcagatca aggttaggaa cagagagaca gcagaatatg ggccaaacag gatatctgtg     2760

gtaagcagtt cctgccccgg ctcagggcca agaacagatg gtccccagat gcggtcccgc     2820

cctcagcagt ttctagagaa ccatcagatg tttccagggt gccccaagga cctgaaatga     2880

ccctgtgcct tatttgaact aaccaatcag ttcgcttctc gcttctgttc gcgcgcttct     2940

gctccccgag ctcaataaaa gagcccacaa cccctcactc ggcgcgccag tcctccgata     3000

gactgcgtcg cccgggtacc cgtgtatcca ataaaccctc ttgcagttgc atccgacttg     3060

tggtctcgct gttccttggg agggtctcct ctgagtgatt gactacccgt cagcgggggt     3120

ctttcatggg taacagtttc ttgaagttgg agaacaacat tctgagggta ggagtcgaat     3180

attaagtaat cctgactcaa ttagccactg ttttgaatcc acatactcca atactcctga     3240

aatagttcat tatggacagc gcagaaagag ctggggagaa ttgtgaaatt gttatccgct     3300

cacaattcca cacaacatac gagccggaag cataaagtgt aaagcctggg gtgcctaatg     3360

agtgagctaa ctcacattaa ttgcgttgcg ctcactgccc gctttccagt cgggaaacct     3420

gtcgtgccag ctgcattaat gaatcggcca acgcgcgggg agaggcggtt tgcgtattgg     3480

gcgctcttcc gcttcctcgc tcactgactc gctgcgctcg gtcgttcggc tgcggcgagc     3540

ggtatcagct cactcaaagg cggtaatacg gttatccaca gaatcagggg ataacgcagg     3600

aaagaacatg tgagcaaaag gccagcaaaa ggccaggaac cgtaaaaagg ccgcgttgct     3660

ggcgtttttc cataggctcc gcccccctga cgagcatcac aaaaatcgac gctcaagtca     3720

gaggtggcga aacccgacag gactataaag ataccaggcg tttccccctg gaagctccct     3780

cgtgcgctct cctgttccga ccctgccgct taccggatac ctgtccgcct ttctcccttc     3840

gggaagcgtg gcgctttctc atagctcacg ctgtaggtat ctcagttcgg tgtaggtcgt     3900

tcgctccaag ctgggctgtg tgcacgaacc ccccgttcag cccgaccgct gcgccttatc     3960

cggtaactat cgtcttgagt ccaacccggt aagacacgac ttatcgccac tggcagcagc     4020

cactggtaac aggattagca gagcgaggta tgtaggcggt gctacagagt tcttgaagtg     4080

gtggcctaac tacggctaca ctagaagaac agtatttggt atctgcgctc tgctgaagcc     4140

agttaccttc ggaaaaagag ttggtagctc ttgatccggc aaacaaacca ccgctggtag     4200

cggtggtttt tttgtttgca agcagcagat tacgcgcaga aaaaaaggat ctcaagaaga     4260

tcctttgatc ttttctacgg ggtctgacgc tcagtggaac gaaaactcac gttaagggat     4320

tttggtcatg agattatcaa aaaggatctt cacctagatc cttttaaatt aaaaatgaag     4380

ttttaaatca atctaaagta tatatgagta aacttggtct gacagttacc aatgcttaat     4440

cagtgaggca cctatctcag cgatctgtct atttcgttca tccatagttg cctgactccc     4500

cgtcgtgtag ataactacga tacgggaggg cttaccatct ggccccagtg ctgcaatgat     4560

accgcgagac ccacgctcac cggctccaga tttatcagca ataaaccagc cagccggaag     4620

ggccgagcgc agaagtggtc ctgcaacttt atccgcctcc atccagtcta ttaattgttg     4680

ccgggaagct agagtaagta gttcgccagt taatagtttg cgcaacgttg ttgccattgc     4740

tacaggcatc gtggtgtcac gctcgtcgtt tggtatggct tcattcagct ccggttccca     4800

acgatcaagg cgagttacat gatcccccat gttgtgcaaa aaagcggtta gctccttcgg     4860

tcctccgatc gttgtcagaa gtaagttggc cgcagtgtta tcactcatgg ttatggcagc     4920

actgcataat tctcttactg tcatgccatc cgtaagatgc ttttctgtga ctggtgagta     4980

ctcaaccaag tcattctgag aatagtgtat gcggcgaccg agttgctctt gcccggcgtc     5040

aatacgggat aataccgcgc cacatagcag aactttaaaa gtgctcatca ttggaaaacg     5100

ttcttcgggg cgaaaactct caaggatctt accgctgttg agatccagtt cgatgtaacc     5160

cactcgtgca cccaactgat cttcagcatc ttttactttc accagcgttt ctgggtgagc     5220

aaaaacagga aggcaaaatg ccgcaaaaaa gggaataagg gcgacacgga aatgttgaat     5280

actcatactc ttcctttttc aatattattg aagcatttat cagggttatt gtctcatgag     5340

cggatacata tttgaatgta tttagaaaaa taaacaaata ggggttccgc gcacatttcc     5400

ccgaaaagtg ccacctgacg tctaagaaac cattattatc atgacattaa cctataaaaa     5460

taggcgtatc acgaggccct ttcgtctcgc gcgtttcggt gatgacggtg aaaacctctg     5520

acacatgcag ctcccggaga cggtcacagc ttgtctgtaa gcggatgccg ggagcagaca     5580

agcccgtcag ggcgcgtcag cgggtgttgg cgggtgtcgg ggctggctta actatgcggc     5640

atcagagcag attgtactga gagtgcacca tatgcggtgt gaaataccgc acagatgcgt     5700

aaggagaaaa taccgcatca ggcgccattc gccattcagg ctgcgcaact gttgggaagg     5760

gcgatcggtg cgggcctctt cgctattacg ccagctggcg aaagggggat gtgctgcaag     5820

gcgattaagt tgggtaacgc cagggttttc ccagtcacga cgttgtaaaa cgacggcgca     5880

aggaatggtg catgcaagga gatggcgccc aacagtcccc cggccacggg gcctgccacc     5940

atacccacgc cgaaacaagc gctcatgagc ccgaagtggc gagcccgatc ttccccatcg     6000

gtgatgtcgg cgatataggc gccagcaacc gcacctgtgg cgccggtgat gccggccacg     6060

atgcgtccgg cgtagaggcg attagtccaa tttgttaaag acaggatatc agtggtccag     6120

gctctagttt tgactcaaca atatcaccag ctgaagccta tagagtacga gccatagata     6180

aaataaaaga ttttatttag tctccagaaa aagggggg                             6218


<210>  671
<211>  1070
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic amino acid

<400>  671

Met Ala Leu Pro Val Thr Ala Leu Leu Leu Pro Leu Ala Leu Leu Leu 
1               5                   10                  15      


His Ala Ala Arg Pro Ser Tyr Val Leu Thr Gln Pro Pro Ser Val Ser 
            20                  25                  30          


Val Ala Pro Gly Gln Thr Ala Arg Ile Thr Cys Gly Gly Asn Asn Ile 
        35                  40                  45              


Gly Arg Lys Ile Val His Trp Tyr Gln Gln Arg Pro Gly Gln Ala Pro 
    50                  55                  60                  


Val Leu Val Ile Tyr Tyr Asp Thr Asp Arg Pro Ala Gly Ile Pro Glu 
65                  70                  75                  80  


Arg Phe Ser Gly Ser Asn Ser Gly Asn Met Ala Thr Leu Thr Ile Ser 
                85                  90                  95      


Thr Val Gly Ala Gly Asp Glu Ala Asp Tyr Tyr Cys Gln Val Trp Asp 
            100                 105                 110         


Thr Gly Ser Asp His Val Val Phe Gly Gly Gly Thr Lys Leu Thr Val 
        115                 120                 125             


Leu Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser 
    130                 135                 140                 


Gly Gly Gly Gly Ser Glu Val Gln Leu Val Glu Ser Gly Gly Gly Leu 
145                 150                 155                 160 


Val Gln Pro Gly Gly Ser Leu Arg Leu Ser Cys Ala Ala Ser Gly Phe 
                165                 170                 175     


Thr Phe Ser Asn Tyr Ala Met Ser Trp Val Arg Gln Ala Pro Gly Lys 
            180                 185                 190         


Gly Leu Glu Trp Val Ser Thr Ile Ser Gly Ser Gly Gly Thr Thr Tyr 
        195                 200                 205             


Tyr Ala Asp Ser Val Lys Gly Arg Phe Thr Ile Ser Arg Asp Asn Ser 
    210                 215                 220                 


Lys Asn Thr Leu Tyr Leu Gln Met Asn Ser Leu Arg Val Glu Asp Thr 
225                 230                 235                 240 


Ala Val Tyr Tyr Cys Ala Lys Asp Trp Phe Arg Ser Ser Ser Pro Asp 
                245                 250                 255     


Ala Phe Asp Ile Trp Gly Gln Gly Thr Thr Val Thr Val Ser Ala Ile 
            260                 265                 270         


Glu Val Met Tyr Pro Pro Pro Tyr Leu Asp Asn Glu Lys Ser Asn Gly 
        275                 280                 285             


Thr Ile Ile His Val Lys Gly Lys His Leu Cys Pro Ser Pro Leu Phe 
    290                 295                 300                 


Pro Gly Pro Ser Lys Pro Phe Trp Val Leu Val Val Val Gly Gly Val 
305                 310                 315                 320 


Leu Ala Cys Tyr Ser Leu Leu Val Thr Val Ala Phe Ile Ile Phe Trp 
                325                 330                 335     


Val Asn Cys Arg Asn Thr Gly Pro Trp Leu Lys Lys Val Leu Lys Cys 
            340                 345                 350         


Asn Thr Pro Asp Pro Ser Lys Phe Phe Ser Gln Leu Ser Ser Glu His 
        355                 360                 365             


Gly Gly Asp Val Gln Lys Trp Leu Ser Ser Pro Phe Pro Ser Ser Ser 
    370                 375                 380                 


Phe Ser Pro Gly Gly Leu Ala Pro Glu Ile Ser Pro Leu Glu Val Leu 
385                 390                 395                 400 


Glu Arg Asp Lys Val Thr Gln Leu Leu Leu Gln Gln Asp Lys Val Pro 
                405                 410                 415     


Glu Pro Ala Ser Leu Ser Ser Asn His Ser Leu Thr Ser Cys Phe Thr 
            420                 425                 430         


Asn Gln Gly Tyr Phe Phe Phe His Leu Pro Asp Ala Leu Glu Ile Glu 
        435                 440                 445             


Ala Cys Gln Val Tyr Phe Thr Tyr Asp Pro Tyr Ser Glu Glu Asp Pro 
    450                 455                 460                 


Asp Glu Gly Val Ala Gly Ala Pro Thr Gly Ser Ser Pro Gln Pro Leu 
465                 470                 475                 480 


Gln Pro Leu Ser Gly Glu Asp Asp Ala Tyr Cys Thr Phe Pro Ser Arg 
                485                 490                 495     


Asp Asp Leu Leu Leu Phe Ser Pro Ser Leu Leu Gly Gly Pro Ser Pro 
            500                 505                 510         


Pro Ser Thr Ala Pro Gly Gly Ser Gly Ala Gly Glu Glu Arg Met Pro 
        515                 520                 525             


Pro Ser Leu Gln Glu Arg Val Pro Arg Asp Trp Asp Pro Gln Pro Leu 
    530                 535                 540                 


Gly Pro Pro Thr Pro Gly Val Pro Asp Leu Val Asp Phe Gln Pro Pro 
545                 550                 555                 560 


Pro Glu Leu Val Leu Arg Glu Ala Gly Glu Glu Val Pro Asp Ala Gly 
                565                 570                 575     


Pro Arg Glu Gly Val Ser Phe Pro Trp Ser Arg Pro Pro Gly Gln Gly 
            580                 585                 590         


Glu Phe Arg Ala Leu Asn Ala Arg Leu Pro Leu Asn Thr Asp Ala Tyr 
        595                 600                 605             


Leu Ser Leu Gln Glu Leu Gln Gly Gln Asp Pro Thr His Leu Val Gly 
    610                 615                 620                 


Ser Gly Glu Gly Arg Gly Ser Leu Leu Thr Cys Gly Asp Val Glu Glu 
625                 630                 635                 640 


Asn Pro Gly Pro Met Ala Leu Pro Val Thr Ala Leu Leu Leu Pro Leu 
                645                 650                 655     


Ala Leu Leu Leu His Ala Ala Arg Pro Asn Phe Met Leu Thr Gln Pro 
            660                 665                 670         


His Ser Val Ser Glu Ser Leu Gly Lys Thr Val Thr Ile Ser Cys Thr 
        675                 680                 685             


Gly Ser Ser Gly Ser Ile Ala Arg Lys Phe Val Gln Trp Tyr Gln Gln 
    690                 695                 700                 


Arg Pro Gly Ser Ser Pro Thr Thr Val Ile Tyr Glu Asn Asn Gln Arg 
705                 710                 715                 720 


Pro Ser Gly Val Ser Asp Arg Phe Ser Gly Ser Ile Gly Ser Ser Ser 
                725                 730                 735     


Asn Ser Ala Ser Leu Thr Ile Ser Gly Leu Lys Thr Glu Asp Glu Ala 
            740                 745                 750         


Asp Tyr Tyr Cys Gln Ser Tyr Asp Ser Ser Asn Val Val Phe Gly Gly 
        755                 760                 765             


Gly Thr Lys Val Thr Val Leu Gly Gly Gly Gly Ser Gly Gly Gly Gly 
    770                 775                 780                 


Ser Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser Gln Val Gln Leu Gln 
785                 790                 795                 800 


Glu Ser Gly Gly Gly Leu Val Lys Pro Gly Gly Ser Leu Arg Leu Ser 
                805                 810                 815     


Cys Ala Ala Ser Gly Phe Thr Phe Ser Ser Tyr Ser Met Asn Trp Val 
            820                 825                 830         


Arg Gln Ala Pro Gly Lys Gly Leu Glu Trp Val Ser Gly Ile Asn Thr 
        835                 840                 845             


Ala Gly Asp Thr His Tyr Pro Glu Ser Val Lys Gly Arg Phe Thr Ile 
    850                 855                 860                 


Ser Arg Asp Asn Ala Arg Asn Ser Leu Asn Leu Gln Met Asn Ser Leu 
865                 870                 875                 880 


Arg Ala Glu Asp Thr Ala Val Tyr Tyr Cys Val Arg Glu Arg Val Glu 
                885                 890                 895     


Arg Glu Tyr Ser Gly Tyr Asp Ala Phe Asp Ile Trp Gly Gln Gly Thr 
            900                 905                 910         


Thr Val Thr Val Ser Ala Ile Glu Val Met Tyr Pro Pro Pro Tyr Leu 
        915                 920                 925             


Asp Asn Glu Lys Ser Asn Gly Thr Ile Ile His Val Lys Gly Lys His 
    930                 935                 940                 


Leu Cys Pro Ser Pro Leu Phe Pro Gly Pro Ser Lys Pro Phe Trp Val 
945                 950                 955                 960 


Leu Val Val Val Gly Gly Val Leu Ala Cys Tyr Ser Leu Leu Val Thr 
                965                 970                 975     


Val Ala Phe Ile Ile Phe Trp Val Glu Arg Thr Met Pro Arg Ile Pro 
            980                 985                 990         


Thr Leu Lys Asn Leu Glu Asp Leu  Val Thr Glu Tyr His  Gly Asn Phe 
        995                 1000                 1005             


Ser Ala  Trp Ser Gly Val Ser  Lys Gly Leu Ala Glu  Ser Leu Gln 
    1010                 1015                 1020             


Pro Asp  Tyr Ser Glu Arg Leu  Cys Leu Val Ser Glu  Ile Pro Pro 
    1025                 1030                 1035             


Lys Gly  Gly Ala Leu Gly Glu  Gly Pro Gly Ala Ser  Pro Cys Asn 
    1040                 1045                 1050             


Gln His  Ser Pro Tyr Trp Ala  Pro Pro Cys Tyr Thr  Leu Lys Pro 
    1055                 1060                 1065             


Glu Thr  
    1070 


<210>  672
<211>  1111
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic amino acid

<400>  672

Met Ala Leu Pro Val Thr Ala Leu Leu Leu Pro Leu Ala Leu Leu Leu 
1               5                   10                  15      


His Ala Ala Arg Pro Ser Tyr Val Leu Thr Gln Pro Pro Ser Val Ser 
            20                  25                  30          


Val Ala Pro Gly Gln Thr Ala Arg Ile Thr Cys Gly Gly Asn Asn Ile 
        35                  40                  45              


Gly Arg Lys Ile Val His Trp Tyr Gln Gln Arg Pro Gly Gln Ala Pro 
    50                  55                  60                  


Val Leu Val Ile Tyr Tyr Asp Thr Asp Arg Pro Ala Gly Ile Pro Glu 
65                  70                  75                  80  


Arg Phe Ser Gly Ser Asn Ser Gly Asn Met Ala Thr Leu Thr Ile Ser 
                85                  90                  95      


Thr Val Gly Ala Gly Asp Glu Ala Asp Tyr Tyr Cys Gln Val Trp Asp 
            100                 105                 110         


Thr Gly Ser Asp His Val Val Phe Gly Gly Gly Thr Lys Leu Thr Val 
        115                 120                 125             


Leu Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser 
    130                 135                 140                 


Gly Gly Gly Gly Ser Glu Val Gln Leu Val Glu Ser Gly Gly Gly Leu 
145                 150                 155                 160 


Val Gln Pro Gly Gly Ser Leu Arg Leu Ser Cys Ala Ala Ser Gly Phe 
                165                 170                 175     


Thr Phe Ser Asn Tyr Ala Met Ser Trp Val Arg Gln Ala Pro Gly Lys 
            180                 185                 190         


Gly Leu Glu Trp Val Ser Thr Ile Ser Gly Ser Gly Gly Thr Thr Tyr 
        195                 200                 205             


Tyr Ala Asp Ser Val Lys Gly Arg Phe Thr Ile Ser Arg Asp Asn Ser 
    210                 215                 220                 


Lys Asn Thr Leu Tyr Leu Gln Met Asn Ser Leu Arg Val Glu Asp Thr 
225                 230                 235                 240 


Ala Val Tyr Tyr Cys Ala Lys Asp Trp Phe Arg Ser Ser Ser Pro Asp 
                245                 250                 255     


Ala Phe Asp Ile Trp Gly Gln Gly Thr Thr Val Thr Val Ser Ala Ile 
            260                 265                 270         


Glu Val Met Tyr Pro Pro Pro Tyr Leu Asp Asn Glu Lys Ser Asn Gly 
        275                 280                 285             


Thr Ile Ile His Val Lys Gly Lys His Leu Cys Pro Ser Pro Leu Phe 
    290                 295                 300                 


Pro Gly Pro Ser Lys Pro Phe Trp Val Leu Val Val Val Gly Gly Val 
305                 310                 315                 320 


Leu Ala Cys Tyr Ser Leu Leu Val Thr Val Ala Phe Ile Ile Phe Trp 
                325                 330                 335     


Val Tyr Arg Val Asp Leu Val Leu Phe Tyr Arg His Leu Thr Arg Arg 
            340                 345                 350         


Asp Glu Thr Leu Thr Asp Gly Lys Thr Tyr Asp Ala Phe Val Ser Tyr 
        355                 360                 365             


Leu Lys Glu Cys Arg Pro Glu Asn Gly Glu Glu His Thr Phe Ala Val 
    370                 375                 380                 


Glu Ile Leu Pro Arg Val Leu Glu Lys His Phe Gly Tyr Lys Leu Cys 
385                 390                 395                 400 


Ile Phe Glu Arg Asp Val Val Pro Gly Gly Ala Val Val Asp Glu Ile 
                405                 410                 415     


His Ser Leu Ile Glu Lys Ser Arg Arg Leu Ile Ile Val Leu Ser Lys 
            420                 425                 430         


Ser Tyr Met Ser Asn Glu Val Arg Tyr Glu Leu Glu Ser Gly Leu His 
        435                 440                 445             


Glu Ala Leu Val Glu Arg Lys Ile Lys Ile Ile Leu Ile Glu Phe Thr 
    450                 455                 460                 


Pro Val Thr Asp Phe Thr Phe Leu Pro Gln Ser Leu Lys Leu Leu Lys 
465                 470                 475                 480 


Ser His Arg Val Leu Lys Trp Lys Ala Asp Lys Ser Leu Ser Tyr Asn 
                485                 490                 495     


Ser Arg Phe Trp Lys Asn Leu Leu Tyr Leu Met Pro Ala Lys Thr Val 
            500                 505                 510         


Lys Pro Gly Arg Asp Glu Pro Glu Val Leu Pro Val Leu Ser Glu Ser 
        515                 520                 525             


Gly Ser Gly Glu Gly Arg Gly Ser Leu Leu Thr Cys Gly Asp Val Glu 
    530                 535                 540                 


Glu Asn Pro Gly Pro Met Ala Leu Pro Val Thr Ala Leu Leu Leu Pro 
545                 550                 555                 560 


Leu Ala Leu Leu Leu His Ala Ala Arg Pro Asn Phe Met Leu Thr Gln 
                565                 570                 575     


Pro His Ser Val Ser Glu Ser Leu Gly Lys Thr Val Thr Ile Ser Cys 
            580                 585                 590         


Thr Gly Ser Ser Gly Ser Ile Ala Arg Lys Phe Val Gln Trp Tyr Gln 
        595                 600                 605             


Gln Arg Pro Gly Ser Ser Pro Thr Thr Val Ile Tyr Glu Asn Asn Gln 
    610                 615                 620                 


Arg Pro Ser Gly Val Ser Asp Arg Phe Ser Gly Ser Ile Gly Ser Ser 
625                 630                 635                 640 


Ser Asn Ser Ala Ser Leu Thr Ile Ser Gly Leu Lys Thr Glu Asp Glu 
                645                 650                 655     


Ala Asp Tyr Tyr Cys Gln Ser Tyr Asp Ser Ser Asn Val Val Phe Gly 
            660                 665                 670         


Gly Gly Thr Lys Val Thr Val Leu Gly Gly Gly Gly Ser Gly Gly Gly 
        675                 680                 685             


Gly Ser Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser Gln Val Gln Leu 
    690                 695                 700                 


Gln Glu Ser Gly Gly Gly Leu Val Lys Pro Gly Gly Ser Leu Arg Leu 
705                 710                 715                 720 


Ser Cys Ala Ala Ser Gly Phe Thr Phe Ser Ser Tyr Ser Met Asn Trp 
                725                 730                 735     


Val Arg Gln Ala Pro Gly Lys Gly Leu Glu Trp Val Ser Gly Ile Asn 
            740                 745                 750         


Thr Ala Gly Asp Thr His Tyr Pro Glu Ser Val Lys Gly Arg Phe Thr 
        755                 760                 765             


Ile Ser Arg Asp Asn Ala Arg Asn Ser Leu Asn Leu Gln Met Asn Ser 
    770                 775                 780                 


Leu Arg Ala Glu Asp Thr Ala Val Tyr Tyr Cys Val Arg Glu Arg Val 
785                 790                 795                 800 


Glu Arg Glu Tyr Ser Gly Tyr Asp Ala Phe Asp Ile Trp Gly Gln Gly 
                805                 810                 815     


Thr Thr Val Thr Val Ser Ala Ile Glu Val Met Tyr Pro Pro Pro Tyr 
            820                 825                 830         


Leu Asp Asn Glu Lys Ser Asn Gly Thr Ile Ile His Val Lys Gly Lys 
        835                 840                 845             


His Leu Cys Pro Ser Pro Leu Phe Pro Gly Pro Ser Lys Pro Phe Trp 
    850                 855                 860                 


Val Leu Val Val Val Gly Gly Val Leu Ala Cys Tyr Ser Leu Leu Val 
865                 870                 875                 880 


Thr Val Ala Phe Ile Ile Phe Trp Val Ser Ala Leu Leu Tyr Arg His 
                885                 890                 895     


Trp Ile Glu Ile Val Leu Leu Tyr Arg Thr Tyr Gln Ser Lys Asp Gln 
            900                 905                 910         


Thr Leu Gly Asp Lys Lys Asp Phe Asp Ala Phe Val Ser Tyr Ala Lys 
        915                 920                 925             


Trp Ser Ser Phe Pro Ser Glu Ala Thr Ser Ser Leu Ser Glu Glu His 
    930                 935                 940                 


Leu Ala Leu Ser Leu Phe Pro Asp Val Leu Glu Asn Lys Tyr Gly Tyr 
945                 950                 955                 960 


Ser Leu Cys Leu Leu Glu Arg Asp Val Ala Pro Gly Gly Val Tyr Ala 
                965                 970                 975     


Glu Asp Ile Val Ser Ile Ile Lys Arg Ser Arg Arg Gly Ile Phe Ile 
            980                 985                 990         


Leu Ser Pro Asn Tyr Val Asn Gly  Pro Ser Ile Phe Glu  Leu Gln Ala 
        995                 1000                 1005             


Ala Val  Asn Leu Ala Leu Asp  Asp Gln Thr Leu Lys  Leu Ile Leu 
    1010                 1015                 1020             


Ile Lys  Phe Cys Tyr Phe Gln  Glu Pro Glu Ser Leu  Pro His Leu 
    1025                 1030                 1035             


Val Lys  Lys Ala Leu Arg Val  Leu Pro Thr Val Thr  Trp Arg Gly 
    1040                 1045                 1050             


Leu Lys  Ser Val Pro Pro Asn  Ser Arg Phe Trp Ala  Lys Met Arg 
    1055                 1060                 1065             


Tyr His  Met Pro Val Lys Asn  Ser Gln Gly Phe Thr  Trp Asn Gln 
    1070                 1075                 1080             


Leu Arg  Ile Thr Ser Arg Ile  Phe Gln Trp Lys Gly  Leu Ser Arg 
    1085                 1090                 1095             


Thr Glu  Thr Thr Gly Arg Ser  Ser Gln Pro Lys Glu  Trp 
    1100                 1105                 1110     


<210>  673
<211>  1061
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic amino acid

<400>  673

Met Ala Leu Pro Val Thr Ala Leu Leu Leu Pro Leu Ala Leu Leu Leu 
1               5                   10                  15      


His Ala Ala Arg Pro Glu Ile Val Leu Thr Gln Ser Pro Ala Thr Leu 
            20                  25                  30          


Ser Leu Ser Pro Gly Glu Arg Ala Thr Leu Ser Cys Arg Ala Ser Gln 
        35                  40                  45              


Thr Ile Gly Thr Ser Ile His Trp Tyr Gln Gln Lys Pro Gly Gln Ala 
    50                  55                  60                  


Pro Arg Leu Leu Ile Tyr Tyr Ala Ser Glu Ser Ile Ser Gly Ile Pro 
65                  70                  75                  80  


Ala Arg Phe Ser Gly Ser Gly Ser Gly Thr Asp Phe Thr Leu Thr Ile 
                85                  90                  95      


Ser Ser Leu Glu Pro Glu Asp Phe Ala Val Tyr Tyr Cys Gln Gln Ser 
            100                 105                 110         


Asn Ser Trp Pro Phe Thr Phe Gly Gln Gly Thr Lys Leu Glu Ile Lys 
        115                 120                 125             


Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser Gly 
    130                 135                 140                 


Gly Gly Gly Ser Gln Val Gln Leu Val Gln Ser Gly Ala Glu Val Lys 
145                 150                 155                 160 


Lys Pro Gly Ala Ser Val Lys Val Ser Cys Lys Ala Ser Gly Tyr Thr 
                165                 170                 175     


Phe Thr Ser Tyr Trp Ile Asn Trp Val Arg Gln Ala Pro Gly Gln Gly 
            180                 185                 190         


Leu Glu Trp Met Gly Asn Ile Tyr Pro Ser Asp Ser Tyr Ser Asn Tyr 
        195                 200                 205             


Asn Gln Lys Phe Lys Asp Arg Val Thr Met Thr Arg Asp Thr Ser Thr 
    210                 215                 220                 


Ser Thr Val Tyr Met Glu Leu Ser Ser Leu Arg Ser Glu Asp Thr Ala 
225                 230                 235                 240 


Val Tyr Tyr Cys Ala Arg Gly Ser Ser Phe Asp Tyr Trp Gly Gln Gly 
                245                 250                 255     


Thr Leu Val Thr Val Ser Lys Pro Thr Thr Thr Pro Ala Pro Arg Pro 
            260                 265                 270         


Pro Thr Pro Ala Pro Thr Ile Ala Ser Gln Pro Leu Ser Leu Arg Pro 
        275                 280                 285             


Glu Ala Cys Arg Pro Ala Ala Gly Gly Ala Val His Thr Arg Gly Leu 
    290                 295                 300                 


Asp Phe Ala Cys Asp Ile Tyr Ile Pro Trp Leu Gly His Leu Leu Val 
305                 310                 315                 320 


Gly Leu Ser Gly Ala Phe Gly Phe Ile Ile Leu Val Tyr Leu Leu Ile 
                325                 330                 335     


Asn Cys Arg Asn Thr Gly Pro Trp Leu Lys Lys Val Leu Lys Cys Asn 
            340                 345                 350         


Thr Pro Asp Pro Ser Lys Phe Phe Ser Gln Leu Ser Ser Glu His Gly 
        355                 360                 365             


Gly Asp Val Gln Lys Trp Leu Ser Ser Pro Phe Pro Ser Ser Ser Phe 
    370                 375                 380                 


Ser Pro Gly Gly Leu Ala Pro Glu Ile Ser Pro Leu Glu Val Leu Glu 
385                 390                 395                 400 


Arg Asp Lys Val Thr Gln Leu Leu Leu Gln Gln Asp Lys Val Pro Glu 
                405                 410                 415     


Pro Ala Ser Leu Ser Ser Asn His Ser Leu Thr Ser Cys Phe Thr Asn 
            420                 425                 430         


Gln Gly Tyr Phe Phe Phe His Leu Pro Asp Ala Leu Glu Ile Glu Ala 
        435                 440                 445             


Cys Gln Val Tyr Phe Thr Tyr Asp Pro Tyr Ser Glu Glu Asp Pro Asp 
    450                 455                 460                 


Glu Gly Val Ala Gly Ala Pro Thr Gly Ser Ser Pro Gln Pro Leu Gln 
465                 470                 475                 480 


Pro Leu Ser Gly Glu Asp Asp Ala Tyr Cys Thr Phe Pro Ser Arg Asp 
                485                 490                 495     


Asp Leu Leu Leu Phe Ser Pro Ser Leu Leu Gly Gly Pro Ser Pro Pro 
            500                 505                 510         


Ser Thr Ala Pro Gly Gly Ser Gly Ala Gly Glu Glu Arg Met Pro Pro 
        515                 520                 525             


Ser Leu Gln Glu Arg Val Pro Arg Asp Trp Asp Pro Gln Pro Leu Gly 
    530                 535                 540                 


Pro Pro Thr Pro Gly Val Pro Asp Leu Val Asp Phe Gln Pro Pro Pro 
545                 550                 555                 560 


Glu Leu Val Leu Arg Glu Ala Gly Glu Glu Val Pro Asp Ala Gly Pro 
                565                 570                 575     


Arg Glu Gly Val Ser Phe Pro Trp Ser Arg Pro Pro Gly Gln Gly Glu 
            580                 585                 590         


Phe Arg Ala Leu Asn Ala Arg Leu Pro Leu Asn Thr Asp Ala Tyr Leu 
        595                 600                 605             


Ser Leu Gln Glu Leu Gln Gly Gln Asp Pro Thr His Leu Val Gly Ser 
    610                 615                 620                 


Gly Glu Gly Arg Gly Ser Leu Leu Thr Cys Gly Asp Val Glu Glu Asn 
625                 630                 635                 640 


Pro Gly Pro Met Ala Leu Pro Val Thr Ala Leu Leu Leu Pro Leu Ala 
                645                 650                 655     


Leu Leu Leu His Ala Ala Arg Pro Glu Ile Val Leu Thr Gln Ser Pro 
            660                 665                 670         


Ala Thr Leu Ser Leu Ser Pro Gly Glu Arg Ala Thr Leu Ser Cys Arg 
        675                 680                 685             


Ala Ser Gln Thr Ile Gly Thr Ser Ile His Trp Tyr Gln Gln Lys Pro 
    690                 695                 700                 


Gly Gln Ala Pro Arg Leu Leu Ile Tyr Tyr Ala Ser Glu Ser Ile Ser 
705                 710                 715                 720 


Gly Ile Pro Ala Arg Phe Ser Gly Ser Gly Ser Gly Thr Asp Phe Thr 
                725                 730                 735     


Leu Thr Ile Ser Ser Leu Glu Pro Glu Asp Phe Ala Val Tyr Tyr Cys 
            740                 745                 750         


Gln Gln Ser Asn Ser Trp Pro Phe Thr Phe Gly Gln Gly Thr Lys Leu 
        755                 760                 765             


Glu Ile Lys Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser Gly Gly Gly 
    770                 775                 780                 


Gly Ser Gly Gly Gly Gly Ser Gln Val Gln Leu Val Gln Ser Gly Ala 
785                 790                 795                 800 


Glu Val Lys Lys Pro Gly Ala Ser Val Lys Val Ser Cys Lys Ala Ser 
                805                 810                 815     


Gly Tyr Thr Phe Thr Ser Tyr Trp Ile Asn Trp Val Arg Gln Ala Pro 
            820                 825                 830         


Gly Gln Gly Leu Glu Trp Met Gly Asn Ile Tyr Pro Ser Asp Ser Tyr 
        835                 840                 845             


Ser Asn Tyr Asn Gln Lys Phe Lys Asp Arg Val Thr Met Thr Arg Asp 
    850                 855                 860                 


Thr Ser Thr Ser Thr Val Tyr Met Glu Leu Ser Ser Leu Arg Ser Glu 
865                 870                 875                 880 


Asp Thr Ala Val Tyr Tyr Cys Ala Arg Gly Ser Ser Phe Asp Tyr Trp 
                885                 890                 895     


Gly Gln Gly Thr Leu Val Thr Val Ser Lys Pro Thr Thr Thr Pro Ala 
            900                 905                 910         


Pro Arg Pro Pro Thr Pro Ala Pro Thr Ile Ala Ser Gln Pro Leu Ser 
        915                 920                 925             


Leu Arg Pro Glu Ala Cys Arg Pro Ala Ala Gly Gly Ala Val His Thr 
    930                 935                 940                 


Arg Gly Leu Asp Phe Ala Cys Asp Ile Tyr Val Val Ile Ser Val Gly 
945                 950                 955                 960 


Ser Met Gly Leu Ile Ile Ser Leu Leu Cys Val Tyr Phe Trp Leu Glu 
                965                 970                 975     


Arg Thr Met Pro Arg Ile Pro Thr Leu Lys Asn Leu Glu Asp Leu Val 
            980                 985                 990         


Thr Glu Tyr His Gly Asn Phe Ser  Ala Trp Ser Gly Val  Ser Lys Gly 
        995                 1000                 1005             


Leu Ala  Glu Ser Leu Gln Pro  Asp Tyr Ser Glu Arg  Leu Cys Leu 
    1010                 1015                 1020             


Val Ser  Glu Ile Pro Pro Lys  Gly Gly Ala Leu Gly  Glu Gly Pro 
    1025                 1030                 1035             


Gly Ala  Ser Pro Cys Asn Gln  His Ser Pro Tyr Trp  Ala Pro Pro 
    1040                 1045                 1050             


Cys Tyr  Thr Leu Lys Pro Glu  Thr 
    1055                 1060     


<210>  674
<211>  1076
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic amino acid

<400>  674

Met Ala Leu Pro Val Thr Ala Leu Leu Leu Pro Leu Ala Leu Leu Leu 
1               5                   10                  15      


His Ala Ala Arg Pro Glu Ile Val Leu Thr Gln Ser Pro Ala Thr Leu 
            20                  25                  30          


Ser Leu Ser Pro Gly Glu Arg Ala Thr Leu Ser Cys Arg Ala Ser Gln 
        35                  40                  45              


Thr Ile Gly Thr Ser Ile His Trp Tyr Gln Gln Lys Pro Gly Gln Ala 
    50                  55                  60                  


Pro Arg Leu Leu Ile Tyr Tyr Ala Ser Glu Ser Ile Ser Gly Ile Pro 
65                  70                  75                  80  


Ala Arg Phe Ser Gly Ser Gly Ser Gly Thr Asp Phe Thr Leu Thr Ile 
                85                  90                  95      


Ser Ser Leu Glu Pro Glu Asp Phe Ala Val Tyr Tyr Cys Gln Gln Ser 
            100                 105                 110         


Asn Ser Trp Pro Phe Thr Phe Gly Gln Gly Thr Lys Leu Glu Ile Lys 
        115                 120                 125             


Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser Gly 
    130                 135                 140                 


Gly Gly Gly Ser Gln Val Gln Leu Val Gln Ser Gly Ala Glu Val Lys 
145                 150                 155                 160 


Lys Pro Gly Ala Ser Val Lys Val Ser Cys Lys Ala Ser Gly Tyr Thr 
                165                 170                 175     


Phe Thr Ser Tyr Trp Ile Asn Trp Val Arg Gln Ala Pro Gly Gln Gly 
            180                 185                 190         


Leu Glu Trp Met Gly Asn Ile Tyr Pro Ser Asp Ser Tyr Ser Asn Tyr 
        195                 200                 205             


Asn Gln Lys Phe Lys Asp Arg Val Thr Met Thr Arg Asp Thr Ser Thr 
    210                 215                 220                 


Ser Thr Val Tyr Met Glu Leu Ser Ser Leu Arg Ser Glu Asp Thr Ala 
225                 230                 235                 240 


Val Tyr Tyr Cys Ala Arg Gly Ser Ser Phe Asp Tyr Trp Gly Gln Gly 
                245                 250                 255     


Thr Leu Val Thr Val Ser Lys Pro Thr Thr Thr Pro Ala Pro Arg Pro 
            260                 265                 270         


Pro Thr Pro Ala Pro Thr Ile Ala Ser Gln Pro Leu Ser Leu Arg Pro 
        275                 280                 285             


Glu Ala Cys Arg Pro Ala Ala Gly Gly Ala Val His Thr Arg Gly Leu 
    290                 295                 300                 


Asp Phe Ala Cys Asp Ile Tyr Tyr Arg Val Asp Leu Val Leu Phe Tyr 
305                 310                 315                 320 


Arg His Leu Thr Arg Arg Asp Glu Thr Leu Thr Asp Gly Lys Thr Tyr 
                325                 330                 335     


Asp Ala Phe Val Ser Tyr Leu Lys Glu Cys Arg Pro Glu Asn Gly Glu 
            340                 345                 350         


Glu His Thr Phe Ala Val Glu Ile Leu Pro Arg Val Leu Glu Lys His 
        355                 360                 365             


Phe Gly Tyr Lys Leu Cys Ile Phe Glu Arg Asp Val Val Pro Gly Gly 
    370                 375                 380                 


Ala Val Val Asp Glu Ile His Ser Leu Ile Glu Lys Ser Arg Arg Leu 
385                 390                 395                 400 


Ile Ile Val Leu Ser Lys Ser Tyr Met Ser Asn Glu Val Arg Tyr Glu 
                405                 410                 415     


Leu Glu Ser Gly Leu His Glu Ala Leu Val Glu Arg Lys Ile Lys Ile 
            420                 425                 430         


Ile Leu Ile Glu Phe Thr Pro Val Thr Asp Phe Thr Phe Leu Pro Gln 
        435                 440                 445             


Ser Leu Lys Leu Leu Lys Ser His Arg Val Leu Lys Trp Lys Ala Asp 
    450                 455                 460                 


Lys Ser Leu Ser Tyr Asn Ser Arg Phe Trp Lys Asn Leu Leu Tyr Leu 
465                 470                 475                 480 


Met Pro Ala Lys Thr Val Lys Pro Gly Arg Asp Glu Pro Glu Val Leu 
                485                 490                 495     


Pro Val Leu Ser Glu Ser Gly Ser Gly Glu Gly Arg Gly Ser Leu Leu 
            500                 505                 510         


Thr Cys Gly Asp Val Glu Glu Asn Pro Gly Pro Met Ala Leu Pro Val 
        515                 520                 525             


Thr Ala Leu Leu Leu Pro Leu Ala Leu Leu Leu His Ala Ala Arg Pro 
    530                 535                 540                 


Glu Ile Val Leu Thr Gln Ser Pro Ala Thr Leu Ser Leu Ser Pro Gly 
545                 550                 555                 560 


Glu Arg Ala Thr Leu Ser Cys Arg Ala Ser Gln Thr Ile Gly Thr Ser 
                565                 570                 575     


Ile His Trp Tyr Gln Gln Lys Pro Gly Gln Ala Pro Arg Leu Leu Ile 
            580                 585                 590         


Tyr Tyr Ala Ser Glu Ser Ile Ser Gly Ile Pro Ala Arg Phe Ser Gly 
        595                 600                 605             


Ser Gly Ser Gly Thr Asp Phe Thr Leu Thr Ile Ser Ser Leu Glu Pro 
    610                 615                 620                 


Glu Asp Phe Ala Val Tyr Tyr Cys Gln Gln Ser Asn Ser Trp Pro Phe 
625                 630                 635                 640 


Thr Phe Gly Gln Gly Thr Lys Leu Glu Ile Lys Gly Gly Gly Gly Ser 
                645                 650                 655     


Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser Gln 
            660                 665                 670         


Val Gln Leu Val Gln Ser Gly Ala Glu Val Lys Lys Pro Gly Ala Ser 
        675                 680                 685             


Val Lys Val Ser Cys Lys Ala Ser Gly Tyr Thr Phe Thr Ser Tyr Trp 
    690                 695                 700                 


Ile Asn Trp Val Arg Gln Ala Pro Gly Gln Gly Leu Glu Trp Met Gly 
705                 710                 715                 720 


Asn Ile Tyr Pro Ser Asp Ser Tyr Ser Asn Tyr Asn Gln Lys Phe Lys 
                725                 730                 735     


Asp Arg Val Thr Met Thr Arg Asp Thr Ser Thr Ser Thr Val Tyr Met 
            740                 745                 750         


Glu Leu Ser Ser Leu Arg Ser Glu Asp Thr Ala Val Tyr Tyr Cys Ala 
        755                 760                 765             


Arg Gly Ser Ser Phe Asp Tyr Trp Gly Gln Gly Thr Leu Val Thr Val 
    770                 775                 780                 


Ser Lys Pro Thr Thr Thr Pro Ala Pro Arg Pro Pro Thr Pro Ala Pro 
785                 790                 795                 800 


Thr Ile Ala Ser Gln Pro Leu Ser Leu Arg Pro Glu Ala Cys Arg Pro 
                805                 810                 815     


Ala Ala Gly Gly Ala Val His Thr Arg Gly Leu Asp Phe Ala Cys Asp 
            820                 825                 830         


Ile Tyr Gly Val Leu Leu Tyr Ile Leu Leu Gly Thr Ile Gly Thr Leu 
        835                 840                 845             


Val Ala Val Leu Ala Ala Ser Ala Leu Leu Tyr Arg His Trp Ile Glu 
    850                 855                 860                 


Ile Val Leu Leu Tyr Arg Thr Tyr Gln Ser Lys Asp Gln Thr Leu Gly 
865                 870                 875                 880 


Asp Lys Lys Asp Phe Asp Ala Phe Val Ser Tyr Ala Lys Trp Ser Ser 
                885                 890                 895     


Phe Pro Ser Glu Ala Thr Ser Ser Leu Ser Glu Glu His Leu Ala Leu 
            900                 905                 910         


Ser Leu Phe Pro Asp Val Leu Glu Asn Lys Tyr Gly Tyr Ser Leu Cys 
        915                 920                 925             


Leu Leu Glu Arg Asp Val Ala Pro Gly Gly Val Tyr Ala Glu Asp Ile 
    930                 935                 940                 


Val Ser Ile Ile Lys Arg Ser Arg Arg Gly Ile Phe Ile Leu Ser Pro 
945                 950                 955                 960 


Asn Tyr Val Asn Gly Pro Ser Ile Phe Glu Leu Gln Ala Ala Val Asn 
                965                 970                 975     


Leu Ala Leu Asp Asp Gln Thr Leu Lys Leu Ile Leu Ile Lys Phe Cys 
            980                 985                 990         


Tyr Phe Gln Glu Pro Glu Ser Leu  Pro His Leu Val Lys  Lys Ala Leu 
        995                 1000                 1005             


Arg Val  Leu Pro Thr Val Thr  Trp Arg Gly Leu Lys  Ser Val Pro 
    1010                 1015                 1020             


Pro Asn  Ser Arg Phe Trp Ala  Lys Met Arg Tyr His  Met Pro Val 
    1025                 1030                 1035             


Lys Asn  Ser Gln Gly Phe Thr  Trp Asn Gln Leu Arg  Ile Thr Ser 
    1040                 1045                 1050             


Arg Ile  Phe Gln Trp Lys Gly  Leu Ser Arg Thr Glu  Thr Thr Gly 
    1055                 1060                 1065             


Arg Ser  Ser Gln Pro Lys Glu  Trp 
    1070                 1075     


<210>  675
<211>  1075
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic amino acid

<400>  675

Met Ala Leu Pro Val Thr Ala Leu Leu Leu Pro Leu Ala Leu Leu Leu 
1               5                   10                  15      


His Ala Ala Arg Pro Gln Ile Gln Leu Val Gln Ser Gly Pro Glu Leu 
            20                  25                  30          


Lys Lys Pro Gly Glu Thr Val Lys Ile Ser Cys Lys Ala Ser Gly Tyr 
        35                  40                  45              


Thr Phe Thr Asn Tyr Gly Met Asn Trp Val Lys Gln Ala Pro Gly Lys 
    50                  55                  60                  


Gly Leu Lys Trp Met Gly Trp Ile Asn Thr Lys Thr Gly Glu Pro Thr 
65                  70                  75                  80  


Tyr Ala Glu Glu Phe Lys Gly Arg Phe Ala Phe Ser Leu Glu Thr Ser 
                85                  90                  95      


Ala Ser Thr Ala Tyr Leu Gln Ile Asn Asn Leu Lys Lys Glu Asp Thr 
            100                 105                 110         


Ala Thr Tyr Phe Cys Gly Arg Gly Gly Tyr Gly Ser Ser Tyr Trp Tyr 
        115                 120                 125             


Phe Asp Val Trp Gly Ala Gly Thr Thr Val Thr Val Ser Ser Ala Ser 
    130                 135                 140                 


Thr Lys Gly Pro Ser Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser Gly 
145                 150                 155                 160 


Gly Gly Gly Ser Gly Gly Gly Gly Ser Asp Ile Val Met Thr Gln Ser 
                165                 170                 175     


His Lys Phe Met Ser Thr Ser Val Gly Asp Arg Val Ser Ile Thr Cys 
            180                 185                 190         


Lys Ala Ser Gln Asp Val Ser Ile Ala Val Ala Trp Tyr Gln Gln Lys 
        195                 200                 205             


Pro Gly Gln Ser Pro Lys Val Leu Ile Tyr Ser Ala Ser Tyr Arg Tyr 
    210                 215                 220                 


Thr Gly Val Pro Asp Arg Phe Thr Gly Ser Gly Ser Gly Thr Asp Phe 
225                 230                 235                 240 


Thr Phe Thr Ile Ser Arg Val Gln Ala Glu Asp Leu Ala Val Tyr Tyr 
                245                 250                 255     


Cys Gln Gln His Tyr Ile Thr Pro Leu Thr Phe Gly Ala Gly Thr Lys 
            260                 265                 270         


Leu Glu Leu Lys Arg Thr Val Ala Ile Glu Val Met Tyr Pro Pro Pro 
        275                 280                 285             


Tyr Leu Asp Asn Glu Lys Ser Asn Gly Thr Ile Ile His Val Lys Gly 
    290                 295                 300                 


Lys His Leu Cys Pro Ser Pro Leu Phe Pro Gly Pro Ser Lys Pro Phe 
305                 310                 315                 320 


Trp Val Leu Val Val Val Gly Gly Val Leu Ala Cys Tyr Ser Leu Leu 
                325                 330                 335     


Val Thr Val Ala Phe Ile Ile Phe Trp Val Asn Cys Arg Asn Thr Gly 
            340                 345                 350         


Pro Trp Leu Lys Lys Val Leu Lys Cys Asn Thr Pro Asp Pro Ser Lys 
        355                 360                 365             


Phe Phe Ser Gln Leu Ser Ser Glu His Gly Gly Asp Val Gln Lys Trp 
    370                 375                 380                 


Leu Ser Ser Pro Phe Pro Ser Ser Ser Phe Ser Pro Gly Gly Leu Ala 
385                 390                 395                 400 


Pro Glu Ile Ser Pro Leu Glu Val Leu Glu Arg Asp Lys Val Thr Gln 
                405                 410                 415     


Leu Leu Leu Gln Gln Asp Lys Val Pro Glu Pro Ala Ser Leu Ser Ser 
            420                 425                 430         


Asn His Ser Leu Thr Ser Cys Phe Thr Asn Gln Gly Tyr Phe Phe Phe 
        435                 440                 445             


His Leu Pro Asp Ala Leu Glu Ile Glu Ala Cys Gln Val Tyr Phe Thr 
    450                 455                 460                 


Tyr Asp Pro Tyr Ser Glu Glu Asp Pro Asp Glu Gly Val Ala Gly Ala 
465                 470                 475                 480 


Pro Thr Gly Ser Ser Pro Gln Pro Leu Gln Pro Leu Ser Gly Glu Asp 
                485                 490                 495     


Asp Ala Tyr Cys Thr Phe Pro Ser Arg Asp Asp Leu Leu Leu Phe Ser 
            500                 505                 510         


Pro Ser Leu Leu Gly Gly Pro Ser Pro Pro Ser Thr Ala Pro Gly Gly 
        515                 520                 525             


Ser Gly Ala Gly Glu Glu Arg Met Pro Pro Ser Leu Gln Glu Arg Val 
    530                 535                 540                 


Pro Arg Asp Trp Asp Pro Gln Pro Leu Gly Pro Pro Thr Pro Gly Val 
545                 550                 555                 560 


Pro Asp Leu Val Asp Phe Gln Pro Pro Pro Glu Leu Val Leu Arg Glu 
                565                 570                 575     


Ala Gly Glu Glu Val Pro Asp Ala Gly Pro Arg Glu Gly Val Ser Phe 
            580                 585                 590         


Pro Trp Ser Arg Pro Pro Gly Gln Gly Glu Phe Arg Ala Leu Asn Ala 
        595                 600                 605             


Arg Leu Pro Leu Asn Thr Asp Ala Tyr Leu Ser Leu Gln Glu Leu Gln 
    610                 615                 620                 


Gly Gln Asp Pro Thr His Leu Val Gly Ser Gly Glu Gly Arg Gly Ser 
625                 630                 635                 640 


Leu Leu Thr Cys Gly Asp Val Glu Glu Asn Pro Gly Pro Met Ala Leu 
                645                 650                 655     


Pro Val Thr Ala Leu Leu Leu Pro Leu Ala Leu Leu Leu His Ala Ala 
            660                 665                 670         


Arg Pro Gln Val Gln Leu Gln Gln Ser Gly Pro Glu Leu Val Arg Pro 
        675                 680                 685             


Gly Thr Ser Val Arg Ile Ser Cys Lys Ala Ser Gly Tyr Thr Phe Thr 
    690                 695                 700                 


Ile Tyr Trp Leu Gly Trp Val Lys Gln Arg Pro Gly His Gly Leu Glu 
705                 710                 715                 720 


Trp Ile Gly Asn Ile Phe Pro Gly Ser Ala Tyr Ile Asn Tyr Asn Glu 
                725                 730                 735     


Lys Phe Lys Gly Lys Ala Thr Leu Thr Ala Asp Thr Ser Ser Ser Thr 
            740                 745                 750         


Ala Tyr Met Gln Leu Ser Ser Leu Thr Ser Glu Asp Ser Ala Val Tyr 
        755                 760                 765             


Phe Cys Ala Arg Glu Gly Ser Asn Ser Gly Tyr Trp Gly Gln Gly Thr 
    770                 775                 780                 


Thr Leu Thr Val Ser Ser Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser 
785                 790                 795                 800 


Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser Asp Ile Val Met Thr Gln 
                805                 810                 815     


Ser Pro Ser Ser Leu Ser Val Ser Ala Gly Glu Lys Val Thr Met Thr 
            820                 825                 830         


Cys Lys Ser Ser Gln Ser Leu Leu Asn Ser Gly Asn Gln Gln Asn Tyr 
        835                 840                 845             


Leu Ala Trp Tyr Gln Gln Lys Pro Gly Gln Pro Pro Lys Leu Leu Ile 
    850                 855                 860                 


Tyr Gly Ala Ser Thr Arg Glu Ser Gly Val Pro Asp Arg Phe Thr Gly 
865                 870                 875                 880 


Ser Gly Ser Gly Thr Asp Phe Thr Leu Thr Ile Asn Ser Val Gln Ala 
                885                 890                 895     


Glu Asp Leu Ala Val Tyr Tyr Cys Gln Ser Asp His Ile Tyr Pro Tyr 
            900                 905                 910         


Thr Phe Gly Gly Gly Thr Lys Leu Glu Ile Lys Ile Glu Val Met Tyr 
        915                 920                 925             


Pro Pro Pro Tyr Leu Asp Asn Glu Lys Ser Asn Gly Thr Ile Ile His 
    930                 935                 940                 


Val Lys Gly Lys His Leu Cys Pro Ser Pro Leu Phe Pro Gly Pro Ser 
945                 950                 955                 960 


Lys Pro Phe Trp Val Leu Val Val Val Gly Gly Val Leu Ala Cys Tyr 
                965                 970                 975     


Ser Leu Leu Val Thr Val Ala Phe Ile Ile Phe Trp Val Glu Arg Thr 
            980                 985                 990         


Met Pro Arg Ile Pro Thr Leu Lys  Asn Leu Glu Asp Leu  Val Thr Glu 
        995                 1000                 1005             


Tyr His  Gly Asn Phe Ser Ala  Trp Ser Gly Val Ser  Lys Gly Leu 
    1010                 1015                 1020             


Ala Glu  Ser Leu Gln Pro Asp  Tyr Ser Glu Arg Leu  Cys Leu Val 
    1025                 1030                 1035             


Ser Glu  Ile Pro Pro Lys Gly  Gly Ala Leu Gly Glu  Gly Pro Gly 
    1040                 1045                 1050             


Ala Ser  Pro Cys Asn Gln His  Ser Pro Tyr Trp Ala  Pro Pro Cys 
    1055                 1060                 1065             


Tyr Thr  Leu Lys Pro Glu Thr  
    1070                 1075 


<210>  676
<211>  1116
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic amino acid

<400>  676

Met Ala Leu Pro Val Thr Ala Leu Leu Leu Pro Leu Ala Leu Leu Leu 
1               5                   10                  15      


His Ala Ala Arg Pro Gln Ile Gln Leu Val Gln Ser Gly Pro Glu Leu 
            20                  25                  30          


Lys Lys Pro Gly Glu Thr Val Lys Ile Ser Cys Lys Ala Ser Gly Tyr 
        35                  40                  45              


Thr Phe Thr Asn Tyr Gly Met Asn Trp Val Lys Gln Ala Pro Gly Lys 
    50                  55                  60                  


Gly Leu Lys Trp Met Gly Trp Ile Asn Thr Lys Thr Gly Glu Pro Thr 
65                  70                  75                  80  


Tyr Ala Glu Glu Phe Lys Gly Arg Phe Ala Phe Ser Leu Glu Thr Ser 
                85                  90                  95      


Ala Ser Thr Ala Tyr Leu Gln Ile Asn Asn Leu Lys Lys Glu Asp Thr 
            100                 105                 110         


Ala Thr Tyr Phe Cys Gly Arg Gly Gly Tyr Gly Ser Ser Tyr Trp Tyr 
        115                 120                 125             


Phe Asp Val Trp Gly Ala Gly Thr Thr Val Thr Val Ser Ser Ala Ser 
    130                 135                 140                 


Thr Lys Gly Pro Ser Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser Gly 
145                 150                 155                 160 


Gly Gly Gly Ser Gly Gly Gly Gly Ser Asp Ile Val Met Thr Gln Ser 
                165                 170                 175     


His Lys Phe Met Ser Thr Ser Val Gly Asp Arg Val Ser Ile Thr Cys 
            180                 185                 190         


Lys Ala Ser Gln Asp Val Ser Ile Ala Val Ala Trp Tyr Gln Gln Lys 
        195                 200                 205             


Pro Gly Gln Ser Pro Lys Val Leu Ile Tyr Ser Ala Ser Tyr Arg Tyr 
    210                 215                 220                 


Thr Gly Val Pro Asp Arg Phe Thr Gly Ser Gly Ser Gly Thr Asp Phe 
225                 230                 235                 240 


Thr Phe Thr Ile Ser Arg Val Gln Ala Glu Asp Leu Ala Val Tyr Tyr 
                245                 250                 255     


Cys Gln Gln His Tyr Ile Thr Pro Leu Thr Phe Gly Ala Gly Thr Lys 
            260                 265                 270         


Leu Glu Leu Lys Arg Thr Val Ala Ile Glu Val Met Tyr Pro Pro Pro 
        275                 280                 285             


Tyr Leu Asp Asn Glu Lys Ser Asn Gly Thr Ile Ile His Val Lys Gly 
    290                 295                 300                 


Lys His Leu Cys Pro Ser Pro Leu Phe Pro Gly Pro Ser Lys Pro Phe 
305                 310                 315                 320 


Trp Val Leu Val Val Val Gly Gly Val Leu Ala Cys Tyr Ser Leu Leu 
                325                 330                 335     


Val Thr Val Ala Phe Ile Ile Phe Trp Val Tyr Arg Val Asp Leu Val 
            340                 345                 350         


Leu Phe Tyr Arg His Leu Thr Arg Arg Asp Glu Thr Leu Thr Asp Gly 
        355                 360                 365             


Lys Thr Tyr Asp Ala Phe Val Ser Tyr Leu Lys Glu Cys Arg Pro Glu 
    370                 375                 380                 


Asn Gly Glu Glu His Thr Phe Ala Val Glu Ile Leu Pro Arg Val Leu 
385                 390                 395                 400 


Glu Lys His Phe Gly Tyr Lys Leu Cys Ile Phe Glu Arg Asp Val Val 
                405                 410                 415     


Pro Gly Gly Ala Val Val Asp Glu Ile His Ser Leu Ile Glu Lys Ser 
            420                 425                 430         


Arg Arg Leu Ile Ile Val Leu Ser Lys Ser Tyr Met Ser Asn Glu Val 
        435                 440                 445             


Arg Tyr Glu Leu Glu Ser Gly Leu His Glu Ala Leu Val Glu Arg Lys 
    450                 455                 460                 


Ile Lys Ile Ile Leu Ile Glu Phe Thr Pro Val Thr Asp Phe Thr Phe 
465                 470                 475                 480 


Leu Pro Gln Ser Leu Lys Leu Leu Lys Ser His Arg Val Leu Lys Trp 
                485                 490                 495     


Lys Ala Asp Lys Ser Leu Ser Tyr Asn Ser Arg Phe Trp Lys Asn Leu 
            500                 505                 510         


Leu Tyr Leu Met Pro Ala Lys Thr Val Lys Pro Gly Arg Asp Glu Pro 
        515                 520                 525             


Glu Val Leu Pro Val Leu Ser Glu Ser Gly Ser Gly Glu Gly Arg Gly 
    530                 535                 540                 


Ser Leu Leu Thr Cys Gly Asp Val Glu Glu Asn Pro Gly Pro Met Ala 
545                 550                 555                 560 


Leu Pro Val Thr Ala Leu Leu Leu Pro Leu Ala Leu Leu Leu His Ala 
                565                 570                 575     


Ala Arg Pro Gln Val Gln Leu Gln Gln Ser Gly Pro Glu Leu Val Arg 
            580                 585                 590         


Pro Gly Thr Ser Val Arg Ile Ser Cys Lys Ala Ser Gly Tyr Thr Phe 
        595                 600                 605             


Thr Ile Tyr Trp Leu Gly Trp Val Lys Gln Arg Pro Gly His Gly Leu 
    610                 615                 620                 


Glu Trp Ile Gly Asn Ile Phe Pro Gly Ser Ala Tyr Ile Asn Tyr Asn 
625                 630                 635                 640 


Glu Lys Phe Lys Gly Lys Ala Thr Leu Thr Ala Asp Thr Ser Ser Ser 
                645                 650                 655     


Thr Ala Tyr Met Gln Leu Ser Ser Leu Thr Ser Glu Asp Ser Ala Val 
            660                 665                 670         


Tyr Phe Cys Ala Arg Glu Gly Ser Asn Ser Gly Tyr Trp Gly Gln Gly 
        675                 680                 685             


Thr Thr Leu Thr Val Ser Ser Gly Gly Gly Gly Ser Gly Gly Gly Gly 
    690                 695                 700                 


Ser Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser Asp Ile Val Met Thr 
705                 710                 715                 720 


Gln Ser Pro Ser Ser Leu Ser Val Ser Ala Gly Glu Lys Val Thr Met 
                725                 730                 735     


Thr Cys Lys Ser Ser Gln Ser Leu Leu Asn Ser Gly Asn Gln Gln Asn 
            740                 745                 750         


Tyr Leu Ala Trp Tyr Gln Gln Lys Pro Gly Gln Pro Pro Lys Leu Leu 
        755                 760                 765             


Ile Tyr Gly Ala Ser Thr Arg Glu Ser Gly Val Pro Asp Arg Phe Thr 
    770                 775                 780                 


Gly Ser Gly Ser Gly Thr Asp Phe Thr Leu Thr Ile Asn Ser Val Gln 
785                 790                 795                 800 


Ala Glu Asp Leu Ala Val Tyr Tyr Cys Gln Ser Asp His Ile Tyr Pro 
                805                 810                 815     


Tyr Thr Phe Gly Gly Gly Thr Lys Leu Glu Ile Lys Ile Glu Val Met 
            820                 825                 830         


Tyr Pro Pro Pro Tyr Leu Asp Asn Glu Lys Ser Asn Gly Thr Ile Ile 
        835                 840                 845             


His Val Lys Gly Lys His Leu Cys Pro Ser Pro Leu Phe Pro Gly Pro 
    850                 855                 860                 


Ser Lys Pro Phe Trp Val Leu Val Val Val Gly Gly Val Leu Ala Cys 
865                 870                 875                 880 


Tyr Ser Leu Leu Val Thr Val Ala Phe Ile Ile Phe Trp Val Ser Ala 
                885                 890                 895     


Leu Leu Tyr Arg His Trp Ile Glu Ile Val Leu Leu Tyr Arg Thr Tyr 
            900                 905                 910         


Gln Ser Lys Asp Gln Thr Leu Gly Asp Lys Lys Asp Phe Asp Ala Phe 
        915                 920                 925             


Val Ser Tyr Ala Lys Trp Ser Ser Phe Pro Ser Glu Ala Thr Ser Ser 
    930                 935                 940                 


Leu Ser Glu Glu His Leu Ala Leu Ser Leu Phe Pro Asp Val Leu Glu 
945                 950                 955                 960 


Asn Lys Tyr Gly Tyr Ser Leu Cys Leu Leu Glu Arg Asp Val Ala Pro 
                965                 970                 975     


Gly Gly Val Tyr Ala Glu Asp Ile Val Ser Ile Ile Lys Arg Ser Arg 
            980                 985                 990         


Arg Gly Ile Phe Ile Leu Ser Pro  Asn Tyr Val Asn Gly  Pro Ser Ile 
        995                 1000                 1005             


Phe Glu  Leu Gln Ala Ala Val  Asn Leu Ala Leu Asp  Asp Gln Thr 
    1010                 1015                 1020             


Leu Lys  Leu Ile Leu Ile Lys  Phe Cys Tyr Phe Gln  Glu Pro Glu 
    1025                 1030                 1035             


Ser Leu  Pro His Leu Val Lys  Lys Ala Leu Arg Val  Leu Pro Thr 
    1040                 1045                 1050             


Val Thr  Trp Arg Gly Leu Lys  Ser Val Pro Pro Asn  Ser Arg Phe 
    1055                 1060                 1065             


Trp Ala  Lys Met Arg Tyr His  Met Pro Val Lys Asn  Ser Gln Gly 
    1070                 1075                 1080             


Phe Thr  Trp Asn Gln Leu Arg  Ile Thr Ser Arg Ile  Phe Gln Trp 
    1085                 1090                 1095             


Lys Gly  Leu Ser Arg Thr Glu  Thr Thr Gly Arg Ser  Ser Gln Pro 
    1100                 1105                 1110             


Lys Glu  Trp 
    1115     


<210>  677
<211>  1008
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic amino acid

<400>  677

Met Ala Leu Pro Val Thr Ala Leu Leu Leu Pro Leu Ala Leu Leu Leu 
1               5                   10                  15      


His Ala Ala Arg Pro Ser Tyr Val Leu Thr Gln Pro Pro Ser Val Ser 
            20                  25                  30          


Val Ala Pro Gly Gln Thr Ala Arg Ile Thr Cys Gly Gly Asn Asn Ile 
        35                  40                  45              


Gly Arg Lys Ile Val His Trp Tyr Gln Gln Arg Pro Gly Gln Ala Pro 
    50                  55                  60                  


Val Leu Val Ile Tyr Tyr Asp Thr Asp Arg Pro Ala Gly Ile Pro Glu 
65                  70                  75                  80  


Arg Phe Ser Gly Ser Asn Ser Gly Asn Met Ala Thr Leu Thr Ile Ser 
                85                  90                  95      


Thr Val Gly Ala Gly Asp Glu Ala Asp Tyr Tyr Cys Gln Val Trp Asp 
            100                 105                 110         


Thr Gly Ser Asp His Val Val Phe Gly Gly Gly Thr Lys Leu Thr Val 
        115                 120                 125             


Leu Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser 
    130                 135                 140                 


Gly Gly Gly Gly Ser Glu Val Gln Leu Val Glu Ser Gly Gly Gly Leu 
145                 150                 155                 160 


Val Gln Pro Gly Gly Ser Leu Arg Leu Ser Cys Ala Ala Ser Gly Phe 
                165                 170                 175     


Thr Phe Ser Asn Tyr Ala Met Ser Trp Val Arg Gln Ala Pro Gly Lys 
            180                 185                 190         


Gly Leu Glu Trp Val Ser Thr Ile Ser Gly Ser Gly Gly Thr Thr Tyr 
        195                 200                 205             


Tyr Ala Asp Ser Val Lys Gly Arg Phe Thr Ile Ser Arg Asp Asn Ser 
    210                 215                 220                 


Lys Asn Thr Leu Tyr Leu Gln Met Asn Ser Leu Arg Val Glu Asp Thr 
225                 230                 235                 240 


Ala Val Tyr Tyr Cys Ala Lys Asp Trp Phe Arg Ser Ser Ser Pro Asp 
                245                 250                 255     


Ala Phe Asp Ile Trp Gly Gln Gly Thr Thr Val Thr Val Ser Ala Phe 
            260                 265                 270         


Arg Thr Lys Pro Ala Ala Leu Gly Lys Asp Thr Ile Pro Trp Leu Gly 
        275                 280                 285             


His Leu Leu Val Gly Leu Ser Gly Ala Phe Gly Phe Ile Ile Leu Val 
    290                 295                 300                 


Tyr Leu Leu Ile Asn Cys Arg Asn Thr Gly Pro Trp Leu Lys Lys Val 
305                 310                 315                 320 


Leu Lys Cys Asn Thr Pro Asp Pro Ser Lys Phe Phe Ser Gln Leu Ser 
                325                 330                 335     


Ser Glu His Gly Gly Asp Val Gln Lys Trp Leu Ser Ser Pro Phe Pro 
            340                 345                 350         


Ser Ser Ser Phe Ser Pro Gly Gly Leu Ala Pro Glu Ile Ser Pro Leu 
        355                 360                 365             


Glu Val Leu Glu Arg Asp Lys Val Thr Gln Leu Leu Leu Gln Gln Asp 
    370                 375                 380                 


Lys Val Pro Glu Pro Ala Ser Leu Ser Ser Asn His Ser Leu Thr Ser 
385                 390                 395                 400 


Cys Phe Thr Asn Gln Gly Tyr Phe Phe Phe His Leu Pro Asp Ala Leu 
                405                 410                 415     


Glu Ile Glu Ala Cys Gln Val Tyr Phe Thr Tyr Asp Pro Tyr Ser Glu 
            420                 425                 430         


Glu Asp Pro Asp Glu Gly Val Ala Gly Ala Pro Thr Gly Ser Ser Pro 
        435                 440                 445             


Gln Pro Leu Gln Pro Leu Ser Gly Glu Asp Asp Ala Tyr Cys Thr Phe 
    450                 455                 460                 


Pro Ser Arg Asp Asp Leu Leu Leu Phe Ser Pro Ser Leu Leu Gly Gly 
465                 470                 475                 480 


Pro Ser Pro Pro Ser Thr Ala Pro Gly Gly Ser Gly Ala Gly Glu Glu 
                485                 490                 495     


Arg Met Pro Pro Ser Leu Gln Glu Arg Val Pro Arg Asp Trp Asp Pro 
            500                 505                 510         


Gln Pro Leu Gly Pro Pro Thr Pro Gly Val Pro Asp Leu Val Asp Phe 
        515                 520                 525             


Gln Pro Pro Pro Glu Leu Val Leu Arg Glu Ala Gly Glu Glu Val Pro 
    530                 535                 540                 


Asp Ala Gly Pro Arg Glu Gly Val Ser Phe Pro Trp Ser Arg Pro Pro 
545                 550                 555                 560 


Gly Gln Gly Glu Phe Arg Ala Leu Asn Ala Arg Leu Pro Leu Asn Thr 
                565                 570                 575     


Asp Ala Tyr Leu Ser Leu Gln Glu Leu Gln Gly Gln Asp Pro Thr His 
            580                 585                 590         


Leu Val Gly Ser Gly Glu Gly Arg Gly Ser Leu Leu Thr Cys Gly Asp 
        595                 600                 605             


Val Glu Glu Asn Pro Gly Pro Met Ala Leu Pro Val Thr Ala Leu Leu 
    610                 615                 620                 


Leu Pro Leu Ala Leu Leu Leu His Ala Ala Arg Pro Asn Phe Met Leu 
625                 630                 635                 640 


Thr Gln Pro His Ser Val Ser Glu Ser Leu Gly Lys Thr Val Thr Ile 
                645                 650                 655     


Ser Cys Thr Gly Ser Ser Gly Ser Ile Ala Arg Lys Phe Val Gln Trp 
            660                 665                 670         


Tyr Gln Gln Arg Pro Gly Ser Ser Pro Thr Thr Val Ile Tyr Glu Asn 
        675                 680                 685             


Asn Gln Arg Pro Ser Gly Val Ser Asp Arg Phe Ser Gly Ser Ile Gly 
    690                 695                 700                 


Ser Ser Ser Asn Ser Ala Ser Leu Thr Ile Ser Gly Leu Lys Thr Glu 
705                 710                 715                 720 


Asp Glu Ala Asp Tyr Tyr Cys Gln Ser Tyr Asp Ser Ser Asn Val Val 
                725                 730                 735     


Phe Gly Gly Gly Thr Lys Val Thr Val Leu Gly Gly Gly Gly Ser Gly 
            740                 745                 750         


Gly Gly Gly Ser Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser Gln Val 
        755                 760                 765             


Gln Leu Gln Glu Ser Gly Gly Gly Leu Val Lys Pro Gly Gly Ser Leu 
    770                 775                 780                 


Arg Leu Ser Cys Ala Ala Ser Gly Phe Thr Phe Ser Ser Tyr Ser Met 
785                 790                 795                 800 


Asn Trp Val Arg Gln Ala Pro Gly Lys Gly Leu Glu Trp Val Ser Gly 
                805                 810                 815     


Ile Asn Thr Ala Gly Asp Thr His Tyr Pro Glu Ser Val Lys Gly Arg 
            820                 825                 830         


Phe Thr Ile Ser Arg Asp Asn Ala Arg Asn Ser Leu Asn Leu Gln Met 
        835                 840                 845             


Asn Ser Leu Arg Ala Glu Asp Thr Ala Val Tyr Tyr Cys Val Arg Glu 
    850                 855                 860                 


Arg Val Glu Arg Glu Tyr Ser Gly Tyr Asp Ala Phe Asp Ile Trp Gly 
865                 870                 875                 880 


Gln Gly Thr Thr Val Thr Val Ser Ala Ser Lys Glu Asn Pro Phe Leu 
                885                 890                 895     


Phe Ala Leu Glu Ala Val Val Ile Ser Val Gly Ser Met Gly Leu Ile 
            900                 905                 910         


Ile Ser Leu Leu Cys Val Tyr Phe Trp Leu Glu Arg Thr Met Pro Arg 
        915                 920                 925             


Ile Pro Thr Leu Lys Asn Leu Glu Asp Leu Val Thr Glu Tyr His Gly 
    930                 935                 940                 


Asn Phe Ser Ala Trp Ser Gly Val Ser Lys Gly Leu Ala Glu Ser Leu 
945                 950                 955                 960 


Gln Pro Asp Tyr Ser Glu Arg Leu Cys Leu Val Ser Glu Ile Pro Pro 
                965                 970                 975     


Lys Gly Gly Ala Leu Gly Glu Gly Pro Gly Ala Ser Pro Cys Asn Gln 
            980                 985                 990         


His Ser Pro Tyr Trp Ala Pro Pro  Cys Tyr Thr Leu Lys  Pro Glu Thr 
        995                 1000                 1005             


<210>  678
<211>  1045
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic amino acid

<400>  678

Met Ala Leu Pro Val Thr Ala Leu Leu Leu Pro Leu Ala Leu Leu Leu 
1               5                   10                  15      


His Ala Ala Arg Pro Ser Tyr Val Leu Thr Gln Pro Pro Ser Val Ser 
            20                  25                  30          


Val Ala Pro Gly Gln Thr Ala Arg Ile Thr Cys Gly Gly Asn Asn Ile 
        35                  40                  45              


Gly Arg Lys Ile Val His Trp Tyr Gln Gln Arg Pro Gly Gln Ala Pro 
    50                  55                  60                  


Val Leu Val Ile Tyr Tyr Asp Thr Asp Arg Pro Ala Gly Ile Pro Glu 
65                  70                  75                  80  


Arg Phe Ser Gly Ser Asn Ser Gly Asn Met Ala Thr Leu Thr Ile Ser 
                85                  90                  95      


Thr Val Gly Ala Gly Asp Glu Ala Asp Tyr Tyr Cys Gln Val Trp Asp 
            100                 105                 110         


Thr Gly Ser Asp His Val Val Phe Gly Gly Gly Thr Lys Leu Thr Val 
        115                 120                 125             


Leu Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser 
    130                 135                 140                 


Gly Gly Gly Gly Ser Glu Val Gln Leu Val Glu Ser Gly Gly Gly Leu 
145                 150                 155                 160 


Val Gln Pro Gly Gly Ser Leu Arg Leu Ser Cys Ala Ala Ser Gly Phe 
                165                 170                 175     


Thr Phe Ser Asn Tyr Ala Met Ser Trp Val Arg Gln Ala Pro Gly Lys 
            180                 185                 190         


Gly Leu Glu Trp Val Ser Thr Ile Ser Gly Ser Gly Gly Thr Thr Tyr 
        195                 200                 205             


Tyr Ala Asp Ser Val Lys Gly Arg Phe Thr Ile Ser Arg Asp Asn Ser 
    210                 215                 220                 


Lys Asn Thr Leu Tyr Leu Gln Met Asn Ser Leu Arg Val Glu Asp Thr 
225                 230                 235                 240 


Ala Val Tyr Tyr Cys Ala Lys Asp Trp Phe Arg Ser Ser Ser Pro Asp 
                245                 250                 255     


Ala Phe Asp Ile Trp Gly Gln Gly Thr Thr Val Thr Val Ser Ala Asp 
            260                 265                 270         


Met Ala Asp Ile Pro Gly His Val Phe Thr Arg Gly Met Ile Ile Ala 
        275                 280                 285             


Val Leu Ile Leu Val Ala Val Val Cys Leu Val Thr Val Cys Val Ile 
    290                 295                 300                 


Tyr Arg Val Asp Leu Val Leu Phe Tyr Arg His Leu Thr Arg Arg Asp 
305                 310                 315                 320 


Glu Thr Leu Thr Asp Gly Lys Thr Tyr Asp Ala Phe Val Ser Tyr Leu 
                325                 330                 335     


Lys Glu Cys Arg Pro Glu Asn Gly Glu Glu His Thr Phe Ala Val Glu 
            340                 345                 350         


Ile Leu Pro Arg Val Leu Glu Lys His Phe Gly Tyr Lys Leu Cys Ile 
        355                 360                 365             


Phe Glu Arg Asp Val Val Pro Gly Gly Ala Val Val Asp Glu Ile His 
    370                 375                 380                 


Ser Leu Ile Glu Lys Ser Arg Arg Leu Ile Ile Val Leu Ser Lys Ser 
385                 390                 395                 400 


Tyr Met Ser Asn Glu Val Arg Tyr Glu Leu Glu Ser Gly Leu His Glu 
                405                 410                 415     


Ala Leu Val Glu Arg Lys Ile Lys Ile Ile Leu Ile Glu Phe Thr Pro 
            420                 425                 430         


Val Thr Asp Phe Thr Phe Leu Pro Gln Ser Leu Lys Leu Leu Lys Ser 
        435                 440                 445             


His Arg Val Leu Lys Trp Lys Ala Asp Lys Ser Leu Ser Tyr Asn Ser 
    450                 455                 460                 


Arg Phe Trp Lys Asn Leu Leu Tyr Leu Met Pro Ala Lys Thr Val Lys 
465                 470                 475                 480 


Pro Gly Arg Asp Glu Pro Glu Val Leu Pro Val Leu Ser Glu Ser Gly 
                485                 490                 495     


Ser Gly Glu Gly Arg Gly Ser Leu Leu Thr Cys Gly Asp Val Glu Glu 
            500                 505                 510         


Asn Pro Gly Pro Met Ala Leu Pro Val Thr Ala Leu Leu Leu Pro Leu 
        515                 520                 525             


Ala Leu Leu Leu His Ala Ala Arg Pro Asn Phe Met Leu Thr Gln Pro 
    530                 535                 540                 


His Ser Val Ser Glu Ser Leu Gly Lys Thr Val Thr Ile Ser Cys Thr 
545                 550                 555                 560 


Gly Ser Ser Gly Ser Ile Ala Arg Lys Phe Val Gln Trp Tyr Gln Gln 
                565                 570                 575     


Arg Pro Gly Ser Ser Pro Thr Thr Val Ile Tyr Glu Asn Asn Gln Arg 
            580                 585                 590         


Pro Ser Gly Val Ser Asp Arg Phe Ser Gly Ser Ile Gly Ser Ser Ser 
        595                 600                 605             


Asn Ser Ala Ser Leu Thr Ile Ser Gly Leu Lys Thr Glu Asp Glu Ala 
    610                 615                 620                 


Asp Tyr Tyr Cys Gln Ser Tyr Asp Ser Ser Asn Val Val Phe Gly Gly 
625                 630                 635                 640 


Gly Thr Lys Val Thr Val Leu Gly Gly Gly Gly Ser Gly Gly Gly Gly 
                645                 650                 655     


Ser Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser Gln Val Gln Leu Gln 
            660                 665                 670         


Glu Ser Gly Gly Gly Leu Val Lys Pro Gly Gly Ser Leu Arg Leu Ser 
        675                 680                 685             


Cys Ala Ala Ser Gly Phe Thr Phe Ser Ser Tyr Ser Met Asn Trp Val 
    690                 695                 700                 


Arg Gln Ala Pro Gly Lys Gly Leu Glu Trp Val Ser Gly Ile Asn Thr 
705                 710                 715                 720 


Ala Gly Asp Thr His Tyr Pro Glu Ser Val Lys Gly Arg Phe Thr Ile 
                725                 730                 735     


Ser Arg Asp Asn Ala Arg Asn Ser Leu Asn Leu Gln Met Asn Ser Leu 
            740                 745                 750         


Arg Ala Glu Asp Thr Ala Val Tyr Tyr Cys Val Arg Glu Arg Val Glu 
        755                 760                 765             


Arg Glu Tyr Ser Gly Tyr Asp Ala Phe Asp Ile Trp Gly Gln Gly Thr 
    770                 775                 780                 


Thr Val Thr Val Ser Ala Asn Thr Thr Gln Ser Val Gln Leu Lys Glu 
785                 790                 795                 800 


Lys Arg Gly Val Val Leu Leu Tyr Ile Leu Leu Gly Thr Ile Gly Thr 
                805                 810                 815     


Leu Val Ala Val Leu Ala Ala Ser Ala Leu Leu Tyr Arg His Trp Ile 
            820                 825                 830         


Glu Ile Val Leu Leu Tyr Arg Thr Tyr Gln Ser Lys Asp Gln Thr Leu 
        835                 840                 845             


Gly Asp Lys Lys Asp Phe Asp Ala Phe Val Ser Tyr Ala Lys Trp Ser 
    850                 855                 860                 


Ser Phe Pro Ser Glu Ala Thr Ser Ser Leu Ser Glu Glu His Leu Ala 
865                 870                 875                 880 


Leu Ser Leu Phe Pro Asp Val Leu Glu Asn Lys Tyr Gly Tyr Ser Leu 
                885                 890                 895     


Cys Leu Leu Glu Arg Asp Val Ala Pro Gly Gly Val Tyr Ala Glu Asp 
            900                 905                 910         


Ile Val Ser Ile Ile Lys Arg Ser Arg Arg Gly Ile Phe Ile Leu Ser 
        915                 920                 925             


Pro Asn Tyr Val Asn Gly Pro Ser Ile Phe Glu Leu Gln Ala Ala Val 
    930                 935                 940                 


Asn Leu Ala Leu Asp Asp Gln Thr Leu Lys Leu Ile Leu Ile Lys Phe 
945                 950                 955                 960 


Cys Tyr Phe Gln Glu Pro Glu Ser Leu Pro His Leu Val Lys Lys Ala 
                965                 970                 975     


Leu Arg Val Leu Pro Thr Val Thr Trp Arg Gly Leu Lys Ser Val Pro 
            980                 985                 990         


Pro Asn Ser Arg Phe Trp Ala Lys  Met Arg Tyr His Met  Pro Val Lys 
        995                 1000                 1005             


Asn Ser  Gln Gly Phe Thr Trp  Asn Gln Leu Arg Ile  Thr Ser Arg 
    1010                 1015                 1020             


Ile Phe  Gln Trp Lys Gly Leu  Ser Arg Thr Glu Thr  Thr Gly Arg 
    1025                 1030                 1035             


Ser Ser  Gln Pro Lys Glu Trp  
    1040                 1045 


<210>  679
<211>  1013
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic amino acid

<400>  679

Met Ala Leu Pro Val Thr Ala Leu Leu Leu Pro Leu Ala Leu Leu Leu 
1               5                   10                  15      


His Ala Ala Arg Pro Gln Ile Gln Leu Val Gln Ser Gly Pro Glu Leu 
            20                  25                  30          


Lys Lys Pro Gly Glu Thr Val Lys Ile Ser Cys Lys Ala Ser Gly Tyr 
        35                  40                  45              


Thr Phe Thr Asn Tyr Gly Met Asn Trp Val Lys Gln Ala Pro Gly Lys 
    50                  55                  60                  


Gly Leu Lys Trp Met Gly Trp Ile Asn Thr Lys Thr Gly Glu Pro Thr 
65                  70                  75                  80  


Tyr Ala Glu Glu Phe Lys Gly Arg Phe Ala Phe Ser Leu Glu Thr Ser 
                85                  90                  95      


Ala Ser Thr Ala Tyr Leu Gln Ile Asn Asn Leu Lys Lys Glu Asp Thr 
            100                 105                 110         


Ala Thr Tyr Phe Cys Gly Arg Gly Gly Tyr Gly Ser Ser Tyr Trp Tyr 
        115                 120                 125             


Phe Asp Val Trp Gly Ala Gly Thr Thr Val Thr Val Ser Ser Ala Ser 
    130                 135                 140                 


Thr Lys Gly Pro Ser Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser Gly 
145                 150                 155                 160 


Gly Gly Gly Ser Gly Gly Gly Gly Ser Asp Ile Val Met Thr Gln Ser 
                165                 170                 175     


His Lys Phe Met Ser Thr Ser Val Gly Asp Arg Val Ser Ile Thr Cys 
            180                 185                 190         


Lys Ala Ser Gln Asp Val Ser Ile Ala Val Ala Trp Tyr Gln Gln Lys 
        195                 200                 205             


Pro Gly Gln Ser Pro Lys Val Leu Ile Tyr Ser Ala Ser Tyr Arg Tyr 
    210                 215                 220                 


Thr Gly Val Pro Asp Arg Phe Thr Gly Ser Gly Ser Gly Thr Asp Phe 
225                 230                 235                 240 


Thr Phe Thr Ile Ser Arg Val Gln Ala Glu Asp Leu Ala Val Tyr Tyr 
                245                 250                 255     


Cys Gln Gln His Tyr Ile Thr Pro Leu Thr Phe Gly Ala Gly Thr Lys 
            260                 265                 270         


Leu Glu Leu Lys Arg Thr Val Ala Phe Arg Thr Lys Pro Ala Ala Leu 
        275                 280                 285             


Gly Lys Asp Thr Ile Pro Trp Leu Gly His Leu Leu Val Gly Leu Ser 
    290                 295                 300                 


Gly Ala Phe Gly Phe Ile Ile Leu Val Tyr Leu Leu Ile Asn Cys Arg 
305                 310                 315                 320 


Asn Thr Gly Pro Trp Leu Lys Lys Val Leu Lys Cys Asn Thr Pro Asp 
                325                 330                 335     


Pro Ser Lys Phe Phe Ser Gln Leu Ser Ser Glu His Gly Gly Asp Val 
            340                 345                 350         


Gln Lys Trp Leu Ser Ser Pro Phe Pro Ser Ser Ser Phe Ser Pro Gly 
        355                 360                 365             


Gly Leu Ala Pro Glu Ile Ser Pro Leu Glu Val Leu Glu Arg Asp Lys 
    370                 375                 380                 


Val Thr Gln Leu Leu Leu Gln Gln Asp Lys Val Pro Glu Pro Ala Ser 
385                 390                 395                 400 


Leu Ser Ser Asn His Ser Leu Thr Ser Cys Phe Thr Asn Gln Gly Tyr 
                405                 410                 415     


Phe Phe Phe His Leu Pro Asp Ala Leu Glu Ile Glu Ala Cys Gln Val 
            420                 425                 430         


Tyr Phe Thr Tyr Asp Pro Tyr Ser Glu Glu Asp Pro Asp Glu Gly Val 
        435                 440                 445             


Ala Gly Ala Pro Thr Gly Ser Ser Pro Gln Pro Leu Gln Pro Leu Ser 
    450                 455                 460                 


Gly Glu Asp Asp Ala Tyr Cys Thr Phe Pro Ser Arg Asp Asp Leu Leu 
465                 470                 475                 480 


Leu Phe Ser Pro Ser Leu Leu Gly Gly Pro Ser Pro Pro Ser Thr Ala 
                485                 490                 495     


Pro Gly Gly Ser Gly Ala Gly Glu Glu Arg Met Pro Pro Ser Leu Gln 
            500                 505                 510         


Glu Arg Val Pro Arg Asp Trp Asp Pro Gln Pro Leu Gly Pro Pro Thr 
        515                 520                 525             


Pro Gly Val Pro Asp Leu Val Asp Phe Gln Pro Pro Pro Glu Leu Val 
    530                 535                 540                 


Leu Arg Glu Ala Gly Glu Glu Val Pro Asp Ala Gly Pro Arg Glu Gly 
545                 550                 555                 560 


Val Ser Phe Pro Trp Ser Arg Pro Pro Gly Gln Gly Glu Phe Arg Ala 
                565                 570                 575     


Leu Asn Ala Arg Leu Pro Leu Asn Thr Asp Ala Tyr Leu Ser Leu Gln 
            580                 585                 590         


Glu Leu Gln Gly Gln Asp Pro Thr His Leu Val Gly Ser Gly Glu Gly 
        595                 600                 605             


Arg Gly Ser Leu Leu Thr Cys Gly Asp Val Glu Glu Asn Pro Gly Pro 
    610                 615                 620                 


Met Ala Leu Pro Val Thr Ala Leu Leu Leu Pro Leu Ala Leu Leu Leu 
625                 630                 635                 640 


His Ala Ala Arg Pro Gln Val Gln Leu Gln Gln Ser Gly Pro Glu Leu 
                645                 650                 655     


Val Arg Pro Gly Thr Ser Val Arg Ile Ser Cys Lys Ala Ser Gly Tyr 
            660                 665                 670         


Thr Phe Thr Ile Tyr Trp Leu Gly Trp Val Lys Gln Arg Pro Gly His 
        675                 680                 685             


Gly Leu Glu Trp Ile Gly Asn Ile Phe Pro Gly Ser Ala Tyr Ile Asn 
    690                 695                 700                 


Tyr Asn Glu Lys Phe Lys Gly Lys Ala Thr Leu Thr Ala Asp Thr Ser 
705                 710                 715                 720 


Ser Ser Thr Ala Tyr Met Gln Leu Ser Ser Leu Thr Ser Glu Asp Ser 
                725                 730                 735     


Ala Val Tyr Phe Cys Ala Arg Glu Gly Ser Asn Ser Gly Tyr Trp Gly 
            740                 745                 750         


Gln Gly Thr Thr Leu Thr Val Ser Ser Gly Gly Gly Gly Ser Gly Gly 
        755                 760                 765             


Gly Gly Ser Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser Asp Ile Val 
    770                 775                 780                 


Met Thr Gln Ser Pro Ser Ser Leu Ser Val Ser Ala Gly Glu Lys Val 
785                 790                 795                 800 


Thr Met Thr Cys Lys Ser Ser Gln Ser Leu Leu Asn Ser Gly Asn Gln 
                805                 810                 815     


Gln Asn Tyr Leu Ala Trp Tyr Gln Gln Lys Pro Gly Gln Pro Pro Lys 
            820                 825                 830         


Leu Leu Ile Tyr Gly Ala Ser Thr Arg Glu Ser Gly Val Pro Asp Arg 
        835                 840                 845             


Phe Thr Gly Ser Gly Ser Gly Thr Asp Phe Thr Leu Thr Ile Asn Ser 
    850                 855                 860                 


Val Gln Ala Glu Asp Leu Ala Val Tyr Tyr Cys Gln Ser Asp His Ile 
865                 870                 875                 880 


Tyr Pro Tyr Thr Phe Gly Gly Gly Thr Lys Leu Glu Ile Lys Ser Lys 
                885                 890                 895     


Glu Asn Pro Phe Leu Phe Ala Leu Glu Ala Val Val Ile Ser Val Gly 
            900                 905                 910         


Ser Met Gly Leu Ile Ile Ser Leu Leu Cys Val Tyr Phe Trp Leu Glu 
        915                 920                 925             


Arg Thr Met Pro Arg Ile Pro Thr Leu Lys Asn Leu Glu Asp Leu Val 
    930                 935                 940                 


Thr Glu Tyr His Gly Asn Phe Ser Ala Trp Ser Gly Val Ser Lys Gly 
945                 950                 955                 960 


Leu Ala Glu Ser Leu Gln Pro Asp Tyr Ser Glu Arg Leu Cys Leu Val 
                965                 970                 975     


Ser Glu Ile Pro Pro Lys Gly Gly Ala Leu Gly Glu Gly Pro Gly Ala 
            980                 985                 990         


Ser Pro Cys Asn Gln His Ser Pro  Tyr Trp Ala Pro Pro  Cys Tyr Thr 
        995                 1000                 1005             


Leu Lys  Pro Glu Thr 
    1010             


<210>  680
<211>  1050
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic amino acid

<400>  680

Met Ala Leu Pro Val Thr Ala Leu Leu Leu Pro Leu Ala Leu Leu Leu 
1               5                   10                  15      


His Ala Ala Arg Pro Gln Ile Gln Leu Val Gln Ser Gly Pro Glu Leu 
            20                  25                  30          


Lys Lys Pro Gly Glu Thr Val Lys Ile Ser Cys Lys Ala Ser Gly Tyr 
        35                  40                  45              


Thr Phe Thr Asn Tyr Gly Met Asn Trp Val Lys Gln Ala Pro Gly Lys 
    50                  55                  60                  


Gly Leu Lys Trp Met Gly Trp Ile Asn Thr Lys Thr Gly Glu Pro Thr 
65                  70                  75                  80  


Tyr Ala Glu Glu Phe Lys Gly Arg Phe Ala Phe Ser Leu Glu Thr Ser 
                85                  90                  95      


Ala Ser Thr Ala Tyr Leu Gln Ile Asn Asn Leu Lys Lys Glu Asp Thr 
            100                 105                 110         


Ala Thr Tyr Phe Cys Gly Arg Gly Gly Tyr Gly Ser Ser Tyr Trp Tyr 
        115                 120                 125             


Phe Asp Val Trp Gly Ala Gly Thr Thr Val Thr Val Ser Ser Ala Ser 
    130                 135                 140                 


Thr Lys Gly Pro Ser Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser Gly 
145                 150                 155                 160 


Gly Gly Gly Ser Gly Gly Gly Gly Ser Asp Ile Val Met Thr Gln Ser 
                165                 170                 175     


His Lys Phe Met Ser Thr Ser Val Gly Asp Arg Val Ser Ile Thr Cys 
            180                 185                 190         


Lys Ala Ser Gln Asp Val Ser Ile Ala Val Ala Trp Tyr Gln Gln Lys 
        195                 200                 205             


Pro Gly Gln Ser Pro Lys Val Leu Ile Tyr Ser Ala Ser Tyr Arg Tyr 
    210                 215                 220                 


Thr Gly Val Pro Asp Arg Phe Thr Gly Ser Gly Ser Gly Thr Asp Phe 
225                 230                 235                 240 


Thr Phe Thr Ile Ser Arg Val Gln Ala Glu Asp Leu Ala Val Tyr Tyr 
                245                 250                 255     


Cys Gln Gln His Tyr Ile Thr Pro Leu Thr Phe Gly Ala Gly Thr Lys 
            260                 265                 270         


Leu Glu Leu Lys Arg Thr Val Ala Asp Met Ala Asp Ile Pro Gly His 
        275                 280                 285             


Val Phe Thr Arg Gly Met Ile Ile Ala Val Leu Ile Leu Val Ala Val 
    290                 295                 300                 


Val Cys Leu Val Thr Val Cys Val Ile Tyr Arg Val Asp Leu Val Leu 
305                 310                 315                 320 


Phe Tyr Arg His Leu Thr Arg Arg Asp Glu Thr Leu Thr Asp Gly Lys 
                325                 330                 335     


Thr Tyr Asp Ala Phe Val Ser Tyr Leu Lys Glu Cys Arg Pro Glu Asn 
            340                 345                 350         


Gly Glu Glu His Thr Phe Ala Val Glu Ile Leu Pro Arg Val Leu Glu 
        355                 360                 365             


Lys His Phe Gly Tyr Lys Leu Cys Ile Phe Glu Arg Asp Val Val Pro 
    370                 375                 380                 


Gly Gly Ala Val Val Asp Glu Ile His Ser Leu Ile Glu Lys Ser Arg 
385                 390                 395                 400 


Arg Leu Ile Ile Val Leu Ser Lys Ser Tyr Met Ser Asn Glu Val Arg 
                405                 410                 415     


Tyr Glu Leu Glu Ser Gly Leu His Glu Ala Leu Val Glu Arg Lys Ile 
            420                 425                 430         


Lys Ile Ile Leu Ile Glu Phe Thr Pro Val Thr Asp Phe Thr Phe Leu 
        435                 440                 445             


Pro Gln Ser Leu Lys Leu Leu Lys Ser His Arg Val Leu Lys Trp Lys 
    450                 455                 460                 


Ala Asp Lys Ser Leu Ser Tyr Asn Ser Arg Phe Trp Lys Asn Leu Leu 
465                 470                 475                 480 


Tyr Leu Met Pro Ala Lys Thr Val Lys Pro Gly Arg Asp Glu Pro Glu 
                485                 490                 495     


Val Leu Pro Val Leu Ser Glu Ser Gly Ser Gly Glu Gly Arg Gly Ser 
            500                 505                 510         


Leu Leu Thr Cys Gly Asp Val Glu Glu Asn Pro Gly Pro Met Ala Leu 
        515                 520                 525             


Pro Val Thr Ala Leu Leu Leu Pro Leu Ala Leu Leu Leu His Ala Ala 
    530                 535                 540                 


Arg Pro Gln Val Gln Leu Gln Gln Ser Gly Pro Glu Leu Val Arg Pro 
545                 550                 555                 560 


Gly Thr Ser Val Arg Ile Ser Cys Lys Ala Ser Gly Tyr Thr Phe Thr 
                565                 570                 575     


Ile Tyr Trp Leu Gly Trp Val Lys Gln Arg Pro Gly His Gly Leu Glu 
            580                 585                 590         


Trp Ile Gly Asn Ile Phe Pro Gly Ser Ala Tyr Ile Asn Tyr Asn Glu 
        595                 600                 605             


Lys Phe Lys Gly Lys Ala Thr Leu Thr Ala Asp Thr Ser Ser Ser Thr 
    610                 615                 620                 


Ala Tyr Met Gln Leu Ser Ser Leu Thr Ser Glu Asp Ser Ala Val Tyr 
625                 630                 635                 640 


Phe Cys Ala Arg Glu Gly Ser Asn Ser Gly Tyr Trp Gly Gln Gly Thr 
                645                 650                 655     


Thr Leu Thr Val Ser Ser Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser 
            660                 665                 670         


Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser Asp Ile Val Met Thr Gln 
        675                 680                 685             


Ser Pro Ser Ser Leu Ser Val Ser Ala Gly Glu Lys Val Thr Met Thr 
    690                 695                 700                 


Cys Lys Ser Ser Gln Ser Leu Leu Asn Ser Gly Asn Gln Gln Asn Tyr 
705                 710                 715                 720 


Leu Ala Trp Tyr Gln Gln Lys Pro Gly Gln Pro Pro Lys Leu Leu Ile 
                725                 730                 735     


Tyr Gly Ala Ser Thr Arg Glu Ser Gly Val Pro Asp Arg Phe Thr Gly 
            740                 745                 750         


Ser Gly Ser Gly Thr Asp Phe Thr Leu Thr Ile Asn Ser Val Gln Ala 
        755                 760                 765             


Glu Asp Leu Ala Val Tyr Tyr Cys Gln Ser Asp His Ile Tyr Pro Tyr 
    770                 775                 780                 


Thr Phe Gly Gly Gly Thr Lys Leu Glu Ile Lys Asn Thr Thr Gln Ser 
785                 790                 795                 800 


Val Gln Leu Lys Glu Lys Arg Gly Val Val Leu Leu Tyr Ile Leu Leu 
                805                 810                 815     


Gly Thr Ile Gly Thr Leu Val Ala Val Leu Ala Ala Ser Ala Leu Leu 
            820                 825                 830         


Tyr Arg His Trp Ile Glu Ile Val Leu Leu Tyr Arg Thr Tyr Gln Ser 
        835                 840                 845             


Lys Asp Gln Thr Leu Gly Asp Lys Lys Asp Phe Asp Ala Phe Val Ser 
    850                 855                 860                 


Tyr Ala Lys Trp Ser Ser Phe Pro Ser Glu Ala Thr Ser Ser Leu Ser 
865                 870                 875                 880 


Glu Glu His Leu Ala Leu Ser Leu Phe Pro Asp Val Leu Glu Asn Lys 
                885                 890                 895     


Tyr Gly Tyr Ser Leu Cys Leu Leu Glu Arg Asp Val Ala Pro Gly Gly 
            900                 905                 910         


Val Tyr Ala Glu Asp Ile Val Ser Ile Ile Lys Arg Ser Arg Arg Gly 
        915                 920                 925             


Ile Phe Ile Leu Ser Pro Asn Tyr Val Asn Gly Pro Ser Ile Phe Glu 
    930                 935                 940                 


Leu Gln Ala Ala Val Asn Leu Ala Leu Asp Asp Gln Thr Leu Lys Leu 
945                 950                 955                 960 


Ile Leu Ile Lys Phe Cys Tyr Phe Gln Glu Pro Glu Ser Leu Pro His 
                965                 970                 975     


Leu Val Lys Lys Ala Leu Arg Val Leu Pro Thr Val Thr Trp Arg Gly 
            980                 985                 990         


Leu Lys Ser Val Pro Pro Asn Ser  Arg Phe Trp Ala Lys  Met Arg Tyr 
        995                 1000                 1005             


His Met  Pro Val Lys Asn Ser  Gln Gly Phe Thr Trp  Asn Gln Leu 
    1010                 1015                 1020             


Arg Ile  Thr Ser Arg Ile Phe  Gln Trp Lys Gly Leu  Ser Arg Thr 
    1025                 1030                 1035             


Glu Thr  Thr Gly Arg Ser Ser  Gln Pro Lys Glu Trp  
    1040                 1045                 1050 


<210>  681
<211>  3024
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Synthetic nucleotide

<400>  681
atggccttgc ccgtcactgc cttgctgctg cctctggcct tactgctgca cgccgccaga       60

cctagctacg tgctgaccca gcctcctagc gtgagcgtgg cccctggcca gaccgctaga      120

atcacctgcg gcggcaacaa catcggaaga aagatcgtgc actggtatca gcagcggcct      180

ggccaagctc ctgtgctggt gatttactac gacaccgaca gaccagccgg tatccccgag      240

cggttcagcg gctctaacag cggaaatatg gcgacactga ccatctccac cgtgggcgcc      300

ggcgatgagg ccgactacta ctgccaagtg tgggatacag gctctgacca cgtggtgttc      360

ggcgggggca ccaagctgac cgtgctggga ggcggcggca gcggcggcgg cggcagcggc      420

ggcggcggca gcggcggagg aggaagcgag gtgcaactgg tcgaatccgg cggagggctg      480

gtacagcctg gtggctcctt gcggctgagc tgcgccgctt ctggcttcac cttcagcaat      540

tacgccatga gctgggttag acaggcccct gggaagggcc tggaatgggt gagcaccatc      600

tcaggcagcg gaggcacaac ctactacgcc gatagcgtga aaggcaggtt cacaatcagc      660

agagataata gcaaaaacac cctgtacctg caaatgaaca gcctgagagt ggaagataca      720

gccgtgtatt actgtgccaa ggactggttc agaagctcca gccctgacgc ctttgacatt      780

tggggccagg ggaccaccgt gaccgtgagt gctttccgga ccaagcctgc cgccctggga      840

aaagacacca tcccttggct gggccacctg ctagtgggcc tttcgggagc cttcggcttc      900

atcatcctgg tgtacctgct gatcaactgc agaaacaccg gcccttggct gaaaaaggtg      960

ctcaagtgca acacacctga ccctagcaag ttcttctctc agctgagcag cgagcacgga     1020

ggcgatgtgc agaaatggct gagcagcccc ttccctagca gctctttcag ccctggaggc     1080

ctggcccctg aaatctctcc tctggaagtg ctggagagag acaaggtgac ccagctgctg     1140

ctgcagcaag acaaggtgcc cgaacccgcc agcctgagca gcaaccacag cctgaccagc     1200

tgttttacaa atcagggcta cttcttcttc cacctgcctg atgccctgga gatcgaggcc     1260

tgtcaggtgt acttcaccta cgatccctac tccgaggagg accctgacga gggcgtggcc     1320

ggtgctccaa caggcagctc gcctcagcct ctgcagcctc tcagcggcga ggacgacgct     1380

tattgcacct ttcctagcag agacgacctg ctgcttttca gcccctccct gctcggcggc     1440

ccctcccccc ccagcaccgc cccaggcgga agcggcgccg gcgaggagcg gatgcctcct     1500

tctctgcagg agagagtgcc tcgggattgg gaccctcagc ctctgggacc tcctacccct     1560

ggcgtgcccg acctggtgga cttccagccc cctcccgagc tggtcctgag agaagccggc     1620

gaggaagtgc ccgacgccgg acctcgggaa ggcgtgtcct tcccctggtc ccggcctcca     1680

ggccagggcg agttcagagc gctgaatgcc agactgccac tgaacaccga cgcctacctg     1740

agcctgcagg agctgcaggg ccaggacccg acccacctgg tgggctctgg cgaaggccgg     1800

ggcagcctgc tgacctgtgg cgatgtggaa gagaaccctg gccctatggc tctccctgtt     1860

acagccctgc ttctgcctct ggctctcctg ctgcatgctg cgcggcccaa ctttatgctg     1920

acccagcccc acagcgtcag tgaaagcctg ggcaaaaccg tgacaatcag ctgcacaggc     1980

agctcaggaa gcatcgccag gaagttcgtg cagtggtatc agcaacggcc aggatcatct     2040

cctacaaccg tgatctacga gaacaaccag agaccttctg gcgtgagtga tagattcagc     2100

ggctctatcg gcagtagctc taatagcgcc tctctgacaa tcagcggcct gaagaccgag     2160

gatgaggccg attactattg ccagtcctac gacagcagca acgtggtgtt cggcggcggc     2220

acaaaggtta ccgtcctggg cggcggaggc tctggcggcg gcggcagcgg cggcggaggc     2280

tctggcggcg gcggtagcca ggtgcaactg caagaatccg gaggcggcct ggtcaagcct     2340

ggtgggagcc tgagactgag ctgcgccgcc agcggcttca cattctccag ctacagcatg     2400

aactgggtcc ggcaggcccc aggcaagggc ctggagtggg tcagcggaat caacaccgcc     2460

ggcgacacac attaccctga gagcgtgaag ggcagattta ccatcagcag agacaacgcc     2520

cggaacagcc tgaacctgca gatgaatagc ctgcgggccg aagatacagc cgtttactac     2580

tgcgtgagag agagagtgga acgcgagtac agcggatatg acgccttcga catctggggc     2640

cagggaacga ccgtgacagt gtcggccagc aaggaaaatc cttttctgtt cgccctggag     2700

gccgtcgtaa tcagcgtggg aagcatgggc ctgatcatca gcctgctgtg tgtgtacttt     2760

tggctggagc gtaccatgcc tagaatcccc accctgaaga acctggagga cctggtgaca     2820

gaataccacg gcaacttcag cgcttggagc ggtgtgtcta agggactggc cgagtctctg     2880

cagccagact acagcgagcg gctgtgcctg gtgagcgaaa tcccaccaaa gggaggggct     2940

ctcggcgaag gccctggcgc ttccccttgt aaccagcact ctccctactg ggctcctcca     3000

tgctacaccc tgaagcctga aacc                                            3024


<210>  682
<211>  3135
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Synthetic nucleotide

<400>  682
atggccctgc cagtgacagc cctgcttctg cctctggctc tgctgctcca cgccgccaga       60

cccagctacg tgctcacaca gcctccttct gtgagcgtgg ccccaggaca gacagccaga      120

atcacctgtg gcggcaacaa catcggcaga aagatcgtgc actggtatca gcaaagacct      180

ggccaggccc ctgtgctggt gatctactac gatactgatc ggcccgccgg catccctgag      240

cggttttctg gctctaactc cggaaatatg gcaacactga caatcagcac agtgggcgcc      300

ggagacgaag ctgactacta ctgccaggtg tgggatactg gctcggacca cgtggttttc      360

ggcggcggca ccaagctgac cgtcctgggc ggcggtggtt cgggcggcgg cggctctggc      420

ggcggcggct ctggcggagg cggcagcgag gtgcagctgg ttgaaagcgg cggcggtctg      480

gtgcagcctg gaggctcctt acggctgtcc tgcgccgcca gcggcttcac tttcagcaac      540

tacgccatga gctgggtccg gcaggcccct ggaaaaggcc tggaatgggt gagcaccatc      600

agcggaagcg gcgggaccac ctattacgcc gacagcgtga agggcagatt taccatcagc      660

agggacaata gcaagaatac cctgtacctg cagatgaaca gcctgcgagt ggaggacaca      720

gccgtctact actgcgccaa ggactggttc agaagcagct ctcctgacgc cttcgacatc      780

tggggccagg gcaccaccgt gactgtcagc gccgacatgg ccgacatccc tggccacgtg      840

tttaccagag gcatgatcat cgccgtgctg attctggtgg ccgtggtttg tctggtgacc      900

gtgtgcgtga tctaccgggt ggacctggtg ctgttctacc ggcatctgac aagaagggac      960

gaaaccttga cggacggcaa gacatacgac gcattcgtgt cttacctgaa ggagtgcaga     1020

cccgagaacg gcgaagaaca cacctttgcc gtggaaatcc tgcctagagt gctggaaaag     1080

cacttcggct acaagctgtg catcttcgag agagatgttg tgcccggcgg agctgtcgtg     1140

gatgagatac acagtctgat cgagaaaagc agaagactga ttatcgtgct ctccaagagc     1200

tatatgagca acgaggtgag atacgagctg gagagcggtc tccacgaggc tctggtcgaa     1260

cggaagatca agattattct gatcgagttc acccctgtta cagacttcac cttcctgcct     1320

cagagcctga agttactgaa gagtcacaga gtgctgaagt ggaaagctga taagagcctg     1380

agctacaaca gccgcttctg gaagaatctg ctctacctga tgcctgccaa aacagtgaag     1440

cctggcaggg atgagcctga ggtgctgccc gtgctgtctg aaagcggctc cggggagggc     1500

agaggctccc tgctgacctg cggcgacgtg gaagagaacc ccggacctat ggctctgcca     1560

gtgaccgctc tgctgctgcc tctggccctg ctgctgcatg ccgccaggcc taacttcatg     1620

ctgacccaac ctcacagcgt gtcggagtct ctgggcaaga ccgtgacaat cagctgcacc     1680

ggaagctctg gcagcatcgc ccgtaaattc gtgcagtggt atcagcagag gccgggctca     1740

tcccctacca ccgtgatcta cgagaacaac cagcggccta gcggcgtgag cgacagattc     1800

agcggaagca tcggaagcag cagcaatagc gcctcactga ccatcagcgg cctgaaaacc     1860

gaggacgaag ccgactacta ctgtcagagc tacgactcca gcaacgtggt tttcggcggc     1920

ggaacaaagg tgaccgtgct gggcggcggc ggatctggtg gcggcggctc cggcggaggc     1980

ggctctgggg gcggcggtag ccaagtgcag ctgcaggaga gcggaggcgg cctggtgaag     2040

ccaggcggct ccctgagact gagctgtgcc gctagtggct ttacctttag cagttacagc     2100

atgaactggg tgagacaggc ccccggcaag ggactggaat gggtgtcagg catcaacacc     2160

gctggcgata cacactaccc cgagagcgtg aaaggcagat tcacaatcag cagagataac     2220

gccagaaaca gcctgaacct gcagatgaat agcttgcggg ccgaggacac cgccgtgtac     2280

tactgcgtgc gggaacgggt ggaaagagag tactcgggat acgacgcctt cgacatctgg     2340

ggacagggaa ccacagtgac agtgtccgcc aacacgaccc agagcgtaca actcaaagaa     2400

aagcggggag tggtcctgct gtatatcctg ctcggcacta tcggcaccct ggtggccgtc     2460

ctggccgcca gcgccctgct gtatagacac tggattgaga tcgtgctcct gtacagaacc     2520

taccagagca aagaccagac gctgggcgac aagaaggatt tcgacgcctt tgtgagctac     2580

gccaaatggt cctccttccc tagcgaggcc acatctagtc tgtctgagga acacctggcc     2640

ctgtcccttt tccccgatgt gctggagaac aagtacggct acagcctgtg cctgctggaa     2700

cgggatgtgg ctcctggagg cgtgtacgcc gaagacatcg tgtctatcat caaaagaagc     2760

cggagaggca tcttcatcct gtctccaaac tacgtgaacg gccctagcat cttcgagctg     2820

caagcggctg ttaacttggc tctggacgac cagaccctga agctgatcct gatcaagttc     2880

tgctacttcc aggagcctga gtccctgccc cacctggtga agaaggccct cagagtgctc     2940

ccaaccgtta catggcgggg cctgaagagc gtgcccccca actccagatt ttgggccaag     3000

atgagatacc acatgcctgt gaagaatagc caaggcttca cctggaacca gctgcggatc     3060

accagccgta tcttccagtg gaagggcctg tctaggaccg agacaaccgg cagatctagc     3120

cagcctaagg aatgg                                                      3135


<210>  683
<211>  3039
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Synthetic nucleotide

<400>  683
atggccctgc ctgtgacagc gctgctgctg ccactggccc tgcttctgca cgccgccaga       60

ccccagatcc agctggtgca gtcaggccct gaactgaaga agcctggaga gacagtgaag      120

attagctgca aggcctcggg atacaccttc acaaactatg gcatgaactg ggtcaaacag      180

gcccctggca agggccttaa atggatgggc tggatcaaca caaagaccgg cgaacccacc      240

tacgccgagg agttcaaggg cagattcgcc ttttctctgg agacatccgc cagcaccgcc      300

tacctgcaga tcaacaacct gaaaaaggaa gatacagcca catacttctg cggacggggc      360

ggatacggta gcagctactg gtacttcgac gtgtggggcg ccggaaccac agtgaccgtt      420

tcgtctgcca gcacaaaagg cccttccggc ggcggaggct ccggcggcgg gggcagtggc      480

ggcggcggct ctggcggcgg aggcagcgac atcgtgatga cccagagcca caagttcatg      540

agcaccagcg tgggcgaccg ggtgtcgatc acctgcaagg ccagtcagga tgtgagcatc      600

gccgtcgcct ggtatcagca aaagcccggc caaagcccta aggtgctgat ctatagcgcc      660

tcctacagat acaccggcgt tcctgacaga ttcacagggt ctggcagcgg caccgatttc      720

accttcacaa tctccagagt gcaggccgag gacctggccg tgtactactg ccagcagcac      780

tacatcacac ctctgacctt tggtgctggc acaaagctgg aactgaaaag aaccgtggcc      840

ttcagaacta agcctgctgc cctcggcaag gacaccatcc cttggctggg ccacctgctg      900

gtgggcctga gcggagcttt tggcttcatc atcctggtct acctgctgat taactgcaga      960

aacaccggtc cttggctgaa gaaagtgctg aagtgcaaca cccccgaccc tagcaagttc     1020

ttcagccagc tgagcagcga gcacggcggg gacgtgcaaa aatggctgag cagccccttc     1080

ccatcttcca gcttcagccc tggcggcctg gctcctgaga tcagccccct ggaagtgctg     1140

gaacgggata aggtgaccca gctgttactc cagcaggaca aggtgcccga acctgccagc     1200

ctgagcagca accacagcct gactagctgc ttcaccaacc agggctactt cttctttcac     1260

ctgcccgacg ccctggagat cgaggcctgc caggtgtact tcacctacga cccttacagc     1320

gaggaggacc ctgacgaggg cgtggccggg gctcctaccg gctcgtctcc tcagcctttg     1380

cagcctctga gcggagagga tgacgcctat tgcacctttc ctagcagaga tgatctgctg     1440

ctcttcagcc cttctctgct gggcggacca agcccacctt ctaccgcacc tggcggctct     1500

ggcgcaggcg aagagcggat gcctccttct ctgcaggaga gagtgccccg ggactgggac     1560

cctcagccgc tgggacctcc tacccctggc gtgccggatc tggtggactt tcagccacca     1620

cctgagctgg tgctgagaga agccggcgaa gaggtgcctg acgccggccc tagggagggc     1680

gtgagcttcc cttggagccg gcctcctgga caaggcgagt tccgcgccct gaacgccaga     1740

ctgcccctga acaccgacgc ctacctgagc ctgcaggagc tgcagggcca ggaccccacc     1800

cacctggtgg gcagcggaga gggaagaggc agcctgttga catgtggcga tgtcgaggaa     1860

aaccctgggc ctatggccct gccagtgaca gcactactcc tgcctctggc cctgctgctc     1920

cacgccgcca gacctcaggt gcagctgcag caatctggcc ccgagctagt gcggcctggc     1980

accagcgtgc ggatttcctg caaggcctct ggctacacct tcacaatcta ttggctgggc     2040

tgggtgaagc agagacctgg acatgggctg gagtggatag gaaacatctt ccctggctca     2100

gcttacatca actacaacga gaagtttaag ggaaaagcca ccctgacagc cgacaccagc     2160

agcagcaccg cctatatgca gctgtctagc ctgacatctg aggatagcgc cgtttacttc     2220

tgcgccagag aaggctccaa ttctggctac tggggccagg gcacaacctt aaccgtgtcc     2280

agcggaggag gcggctctgg cggcggcggt tcaggcgggg gcggaagcgg cggtggaggc     2340

tctgacattg tgatgaccca gagccccagc agcctgagcg tgtctgctgg cgagaaggtg     2400

accatgacct gtaaatctag ccagagcctg ctgaacagcg gcaaccagca gaactacctg     2460

gcctggtatc agcagaaacc tggccagccc cccaagctgc tgatctacgg cgccagcacc     2520

agagaaagcg gcgtgcctga cagattcact ggcagcggca gcggcacaga cttcaccctg     2580

accatcaata gcgtgcaggc cgaagatctg gctgtgtact actgtcagag cgaccacatc     2640

tacccttaca ccttcggcgg aggcaccaag ctagaaatca agagcaagga aaatccattt     2700

ctgtttgccc tggaagccgt ggtgatcagc gtgggaagca tgggcctgat catctcgctg     2760

ctgtgcgtgt acttctggct ggaaaggacc atgccccgca tccctaccct caagaacctg     2820

gaggacctgg tcacagagta ccacggcaat ttcagcgcct ggtccggcgt gtccaagggc     2880

ctggccgaga gcctgcaacc cgattacagt gaacggctgt gtctggtgtc tgagatcccc     2940

ccgaagggag gcgccctggg agaaggccca ggcgccagcc cttgtaatca gcatagccct     3000

tactgggctc ctccatgtta caccctgaag cccgaaacc                            3039


<210>  684
<211>  3150
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Synthetic nucleotide

<400>  684
atggccctgc ctgtgaccgc gctgctgctg cctctggccc tgctgctgca tgccgccagg       60

ccacagatcc agctggtgca gagcggacct gaactgaaga agcctgggga aaccgtgaag      120

atcagctgca aggcctccgg ctacaccttc acaaactacg gcatgaactg ggtgaagcag      180

gcccctggaa agggcctgaa atggatgggc tggatcaaca ccaagaccgg cgagcctacc      240

tacgccgaag agttcaaggg cagattcgcc ttcagcctgg agacctcagc cagcaccgcc      300

tacctgcaga tcaacaacct gaagaaggaa gataccgcca cctacttctg cggccggggc      360

ggttatggca gcagctactg gtacttcgac gtgtggggcg ccggcacaac agtgacagta      420

tccagcgcct ccacaaaagg acctagcggc ggcggcggca gcggtggtgg cggaagtggc      480

ggcggcggca gcggcggcgg tggaagcgac atcgtgatga cccagagcca taagttcatg      540

agcacaagcg tgggcgatcg ggtgagcatc acctgcaagg cctctcagga cgtgagcatc      600

gccgtggcct ggtatcagca gaaacctggg cagtccccta aggtgttgat ctattctgct      660

tcctaccgat acacaggagt gcctgaccgg ttcaccggct ctggcagcgg caccgatttc      720

acctttacaa tcagcagagt gcaggctgag gacctggccg tgtactactg tcagcagcac      780

tacatcaccc ctctgacctt tggcgccgga actaaactgg aactgaagcg gaccgtggcc      840

gatatggctg atatacccgg ccacgtgttc actagaggca tgatcattgc cgtgttgatc      900

ctggtggccg tggtttgcct ggtgaccgtg tgcgtgatct acagagtgga cctggtcctg      960

ttctacagac acctgaccag acgcgacgag accctgacag acggcaaaac atacgacgcc     1020

ttcgtgtcct acctgaaaga gtgcagacct gagaatggcg aggaacacac ctttgccgtc     1080

gagatcctgc ccagagtgct ggaaaagcac ttcggctata agctgtgtat cttcgagcgg     1140

gacgtggtgc caggcggcgc cgtggtggac gagatccaca gcctgattga gaaaagccgg     1200

cggctgatca tcgtgctgag caagtcgtac atgagcaatg aagtgcggta cgagctggaa     1260

agcggcctgc acgaggccct ggtcgagaga aagattaaga tcatcctgat cgagtttaca     1320

cccgtgacag actttacctt cctgccccag agcctgaaac tgctgaagag ccatagagtg     1380

ctgaagtgga aggctgataa gtctctgagc tacaactctc gcttctggaa gaacctgctc     1440

tacctgatgc ctgccaagac agttaagccc ggcagagacg agcccgaggt gctgcctgtg     1500

ctttccgaga gcggatctgg cgaaggcaga ggttccctgc ttacatgtgg cgacgtggag     1560

gaaaatcctg gccctatggc cctgcctgtt accgctctgc tgctgcctct ggccctgctg     1620

ctgcacgccg ctagacctca ggtgcaactg caacagagcg gccctgaact ggtcagaccc     1680

ggaacctccg tgcggatcag ttgcaaggcc agcggctaca ccttcaccat ctactggctg     1740

ggatgggtta agcagagacc tggccacggc ttggagtgga tcggcaacat ctttcccggc     1800

tccgcctata tcaactacaa cgagaaattc aaagggaagg cgaccctgac agccgacacc     1860

agcagttcca ccgcctacat gcagctgtcc agcctgacat ctgaggacag cgcagtgtat     1920

ttttgcgcca gagaaggcag caacagcgga tactggggac agggcaccac actcaccgtg     1980

agcagcggag gcggcggcag cggcggcggc ggaagcggcg gcggcgggag cggcggcggc     2040

ggatctgaca tcgtgatgac ccaaagccct agcagcctga gtgtgagcgc cggcgagaag     2100

gtgaccatga cctgtaaaag cagccagtcg ctgctgaaca gcggcaatca gcagaactac     2160

ctggcatggt atcagcaaaa gcccggccag cctccaaagc tgcttatcta cggtgccagc     2220

acccgggaga gcggcgttcc tgatcggttc actggaagtg gcagcggaac cgacttcaca     2280

ctgacgatca atagcgtgca ggccgaggac ctggccgtgt actactgcca aagcgaccac     2340

atctacccct acaccttcgg ggggggcacc aagctcgaaa tcaagaacac aacacagtct     2400

gtgcagctga aagagaagag aggcgtggtt ctgctgtaca tccttcttgg aaccatcggc     2460

accctggtgg ccgtgttagc cgcctctgct ctgctgtacc ggcactggat cgagatcgtg     2520

ctgctgtata gaacatacca gtctaaggac cagaccctgg gcgacaagaa agatttcgat     2580

gccttcgtgt cctacgctaa gtggagcagc ttcccttctg aagccacctc tagcctgtct     2640

gaagagcacc tggccctgag cctgtttcca gatgtgctgg agaacaagta cggatacagc     2700

ctgtgcctgc tggaaagaga cgtggcccct ggaggcgtgt acgccgaaga catcgtcagc     2760

atcatcaagc ggagcagaag aggcatcttc atcctgagcc caaactacgt gaacggcccc     2820

agcatcttcg agctgcaggc cgccgtgaac ctggctcttg atgaccaaac actgaagctg     2880

atcctgatca agttctgcta ctttcaggag cctgaatccc tgccgcacct ggtgaagaag     2940

gccctgagag ttctgcccac cgtgacctgg cgcggactga aatctgttcc tcctaatagc     3000

aggttctggg ccaagatgag ataccacatg ccagtgaaga acagccaggg gttcacctgg     3060

aaccagctga gaatcacaag cagaatcttc cagtggaagg gcctgtctcg aacagagacc     3120

accggcagaa gcagccaacc taaggaatgg                                      3150


<210>  685
<211>  11253
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Synthetic amino acid

<400>  685
gtcgacggat cgggagatct cccgatcccc tatggtgcac tctcagtaca atctgctctg       60

atgccgcata gttaagccag tatctgctcc ctgcttgtgt gttggaggtc gctgagtagt      120

gcgcgagcaa aatttaagct acaacaaggc aaggcttgac cgacaattgc atgaagaatc      180

tgcttagggt taggcgtttt gcgctgcttc gcgatgtacg ggccagatat acgcgttgac      240

attgattatt gactagttat taatagtaat caattacggg gtcattagtt catagcccat      300

atatggagtt ccgcgttaca taacttacgg taaatggccc gcctggctga ccgcccaacg      360

acccccgccc attgacgtca ataatgacgt atgttcccat agtaacgcca atagggactt      420

tccattgacg tcaatgggtg gagtatttac ggtaaactgc ccacttggca gtacatcaag      480

tgtatcatat gccaagtacg ccccctattg acgtcaatga cggtaaatgg cccgcctggc      540

attatgccca gtacatgacc ttatgggact ttcctacttg gcagtacatc tacgtattag      600

tcatcgctat taccatggtg atgcggtttt ggcagtacat caatgggcgt ggatagcggt      660

ttgactcacg gggatttcca agtctccacc ccattgacgt caatgggagt ttgttttggc      720

accaaaatca acgggacttt ccaaaatgtc gtaacaactc cgccccattg acgcaaatgg      780

gcggtaggcg tgtacggtgg gaggtctata taagcagcgc gttttgcctg tactgggtct      840

ctctggttag accagatctg agcctgggag ctctctggct aactagggaa cccactgctt      900

aagcctcaat aaagcttgcc ttgagtgctt caagtagtgt gtgcccgtct gttgtgtgac      960

tctggtaact agagatccct cagacccttt tagtcagtgt ggaaaatctc tagcagtggc     1020

gcccgaacag ggacttgaaa gcgaaaggga aaccagagga gctctctcga cgcaggactc     1080

ggcttgctga agcgcgcacg gcaagaggcg aggggcggcg actggtgagt acgccaaaaa     1140

ttttgactag cggaggctag aaggagagag atgggtgcga gagcgtcagt attaagcggg     1200

ggagaattag atcgcgatgg gaaaaaattc ggttaaggcc agggggaaag aaaaaatata     1260

aattaaaaca tatagtatgg gcaagcaggg agctagaacg attcgcagtt aatcctggcc     1320

tgttagaaac atcagaaggc tgtagacaaa tactgggaca gctacaacca tcccttcaga     1380

caggatcaga agaacttaga tcattatata atacagtagc aaccctctat tgtgtgcatc     1440

aaaggataga gataaaagac accaaggaag ctttagacaa gatagaggaa gagcaaaaca     1500

aaagtaagac caccgcacag caagcggccg ctgatcttca gacctggagg aggagatatg     1560

agggacaatt ggagaagtga attatataaa tataaagtag taaaaattga accattagga     1620

gtagcaccca ccaaggcaaa gagaagagtg gtgcagagag aaaaaagagc agtgggaata     1680

ggagctttgt tccttgggtt cttgggagca gcaggaagca ctatgggcgc agcgtcaatg     1740

acgctgacgg tacaggccag acaattattg tctggtatag tgcagcagca gaacaatttg     1800

ctgagggcta ttgaggcgca acagcatctg ttgcaactca cagtctgggg catcaagcag     1860

ctccaggcaa gaatcctggc tgtggaaaga tacctaaagg atcaacagct cctggggatt     1920

tggggttgct ctggaaaact catttgcacc actgctgtgc cttggaatgc tagttggagt     1980

aataaatctc tggaacagat ttggaatcac acgacctgga tggagtggga cagagaaatt     2040

aacaattaca caagcttaat acactcctta attgaagaat cgcaaaacca gcaagaaaag     2100

aatgaacaag aattattgga attagataaa tgggcaagtt tgtggaattg gtttaacata     2160

acaaattggc tgtggtatat aaaattattc ataatgatag taggaggctt ggtaggttta     2220

agaatagttt ttgctgtact ttctatagtg aatagagtta ggcagggata ttcaccatta     2280

tcgtttcaga cccacctccc aaccccgagg ggacccgaca ggcccgaagg aatagaagaa     2340

gaaggtggag agagagacag agacagatcc attcgattag tgaacggatc ggcactgcgt     2400

gcgccaattc tgcagacaaa tggcagtatt catccacaat tttaaaagaa aaggggggat     2460

tggggggtac agtgcagggg aaagaatagt agacataata gcaacagaca tacaaactaa     2520

agaattacaa aaacaaatta caaaaattca aaattttcgg gtttattaca gggacagcag     2580

agatccagtt tggttaatta gctagctagg tcttgaaagg agtgggaatt ggctccggtg     2640

cccgtcagtg ggcagagcgc acatcgccca cagtccccga gaagttgggg ggaggggtcg     2700

gcaattgatc cggtgcctag agaaggtggc gcggggtaaa ctgggaaagt gatgtcgtgt     2760

actggctccg cctttttccc gagggtgggg gagaaccgta tataagtgca gtagtcgccg     2820

tgaacgttct ttttcgcaac gggtttgccg ccagaacaca ggaccggttc tagagcgctt     2880

taattaagcc accatggcct tgcccgtcac tgccttgctg ctgcctctgg ccttactgct     2940

gcacgccgcc agacctagct acgtgctgac ccagcctcct agcgtgagcg tggcccctgg     3000

ccagaccgct agaatcacct gcggcggcaa caacatcgga agaaagatcg tgcactggta     3060

tcagcagcgg cctggccaag ctcctgtgct ggtgatttac tacgacaccg acagaccagc     3120

cggtatcccc gagcggttca gcggctctaa cagcggaaat atggcgacac tgaccatctc     3180

caccgtgggc gccggcgatg aggccgacta ctactgccaa gtgtgggata caggctctga     3240

ccacgtggtg ttcggcgggg gcaccaagct gaccgtgctg ggaggcggcg gcagcggcgg     3300

cggcggcagc ggcggcggcg gcagcggcgg aggaggaagc gaggtgcaac tggtcgaatc     3360

cggcggaggg ctggtacagc ctggtggctc cttgcggctg agctgcgccg cttctggctt     3420

caccttcagc aattacgcca tgagctgggt tagacaggcc cctgggaagg gcctggaatg     3480

ggtgagcacc atctcaggca gcggaggcac aacctactac gccgatagcg tgaaaggcag     3540

gttcacaatc agcagagata atagcaaaaa caccctgtac ctgcaaatga acagcctgag     3600

agtggaagat acagccgtgt attactgtgc caaggactgg ttcagaagct ccagccctga     3660

cgcctttgac atttggggcc aggggaccac cgtgaccgtg agtgctttcc ggaccaagcc     3720

tgccgccctg ggaaaagaca ccatcccttg gctgggccac ctgctagtgg gcctttcggg     3780

agccttcggc ttcatcatcc tggtgtacct gctgatcaac tgcagaaaca ccggcccttg     3840

gctgaaaaag gtgctcaagt gcaacacacc tgaccctagc aagttcttct ctcagctgag     3900

cagcgagcac ggaggcgatg tgcagaaatg gctgagcagc cccttcccta gcagctcttt     3960

cagccctgga ggcctggccc ctgaaatctc tcctctggaa gtgctggaga gagacaaggt     4020

gacccagctg ctgctgcagc aagacaaggt gcccgaaccc gccagcctga gcagcaacca     4080

cagcctgacc agctgtttta caaatcaggg ctacttcttc ttccacctgc ctgatgccct     4140

ggagatcgag gcctgtcagg tgtacttcac ctacgatccc tactccgagg aggaccctga     4200

cgagggcgtg gccggtgctc caacaggcag ctcgcctcag cctctgcagc ctctcagcgg     4260

cgaggacgac gcttattgca cctttcctag cagagacgac ctgctgcttt tcagcccctc     4320

cctgctcggc ggcccctccc cccccagcac cgccccaggc ggaagcggcg ccggcgagga     4380

gcggatgcct ccttctctgc aggagagagt gcctcgggat tgggaccctc agcctctggg     4440

acctcctacc cctggcgtgc ccgacctggt ggacttccag ccccctcccg agctggtcct     4500

gagagaagcc ggcgaggaag tgcccgacgc cggacctcgg gaaggcgtgt ccttcccctg     4560

gtcccggcct ccaggccagg gcgagttcag agcgctgaat gccagactgc cactgaacac     4620

cgacgcctac ctgagcctgc aggagctgca gggccaggac ccgacccacc tggtgggctc     4680

tggcgaaggc cggggcagcc tgctgacctg tggcgatgtg gaagagaacc ctggccctat     4740

ggctctccct gttacagccc tgcttctgcc tctggctctc ctgctgcatg ctgcgcggcc     4800

caactttatg ctgacccagc cccacagcgt cagtgaaagc ctgggcaaaa ccgtgacaat     4860

cagctgcaca ggcagctcag gaagcatcgc caggaagttc gtgcagtggt atcagcaacg     4920

gccaggatca tctcctacaa ccgtgatcta cgagaacaac cagagacctt ctggcgtgag     4980

tgatagattc agcggctcta tcggcagtag ctctaatagc gcctctctga caatcagcgg     5040

cctgaagacc gaggatgagg ccgattacta ttgccagtcc tacgacagca gcaacgtggt     5100

gttcggcggc ggcacaaagg ttaccgtcct gggcggcgga ggctctggcg gcggcggcag     5160

cggcggcgga ggctctggcg gcggcggtag ccaggtgcaa ctgcaagaat ccggaggcgg     5220

cctggtcaag cctggtggga gcctgagact gagctgcgcc gccagcggct tcacattctc     5280

cagctacagc atgaactggg tccggcaggc cccaggcaag ggcctggagt gggtcagcgg     5340

aatcaacacc gccggcgaca cacattaccc tgagagcgtg aagggcagat ttaccatcag     5400

cagagacaac gcccggaaca gcctgaacct gcagatgaat agcctgcggg ccgaagatac     5460

agccgtttac tactgcgtga gagagagagt ggaacgcgag tacagcggat atgacgcctt     5520

cgacatctgg ggccagggaa cgaccgtgac agtgtcggcc agcaaggaaa atccttttct     5580

gttcgccctg gaggccgtcg taatcagcgt gggaagcatg ggcctgatca tcagcctgct     5640

gtgtgtgtac ttttggctgg agcgtaccat gcctagaatc cccaccctga agaacctgga     5700

ggacctggtg acagaatacc acggcaactt cagcgcttgg agcggtgtgt ctaagggact     5760

ggccgagtct ctgcagccag actacagcga gcggctgtgc ctggtgagcg aaatcccacc     5820

aaagggaggg gctctcggcg aaggccctgg cgcttcccct tgtaaccagc actctcccta     5880

ctgggctcct ccatgctaca ccctgaagcc tgaaacctga gaattcgata tcaagcttat     5940

cggtaatcaa cctctggatt acaaaatttg tgaaagattg actggtattc ttaactatgt     6000

tgctcctttt acgctatgtg gatacgctgc tttaatgcct ttgtatcatg ctattgcttc     6060

ccgtatggct ttcattttct cctccttgta taaatcctgg ttgctgtctc tttatgagga     6120

gttgtggccc gttgtcaggc aacgtggcgt ggtgtgcact gtgtttgctg acgcaacccc     6180

cactggttgg ggcattgcca ccacctgtca gctcctttcc gggactttcg ctttccccct     6240

ccctattgcc acggcggaac tcatcgccgc ctgccttgcc cgctgctgga caggggctcg     6300

gctgttgggc actgacaatt ccgtggtgtt gtcggggaaa tcatcgtcct ttccttggct     6360

gctcgcctgt gttgccacct ggattctgcg cgggacgtcc ttctgctacg tcccttcggc     6420

cctcaatcca gcggaccttc cttcccgcgg cctgctgccg gctctgcggc ctcttccgcg     6480

tcttcgcctt cgccctcaga cgagtcggat ctccctttgg gccgcctccc cgcatcgata     6540

ccgtcgacct cgagacctag aaaaacatgg agcaatcaca agtagcaata cagcagctac     6600

caatgctgat tgtgcctggc tagaagcaca agaggaggag gaggtgggtt ttccagtcac     6660

acctcaggta cctttaagac caatgactta caaggcagct gtagatctta gccacttttt     6720

aaaagaaaag gggggactgg aagggctaat tcactcccaa cgaagacaag atatccttga     6780

tctgtggatc taccacacac aaggctactt ccctgattgg cagaactaca caccagggcc     6840

agggatcaga tatccactga cctttggatg gtgctacaag ctagtaccag ttgagcaaga     6900

gaaggtagaa gaagccaatg aaggagagaa cacccgcttg ttacaccctg tgagcctgca     6960

tgggatggat gacccggaga gagaagtatt agagtggagg tttgacagcc gcctagcatt     7020

tcatcacatg gcccgagagc tgcatccgga ctgtactggg tctctctggt tagaccagat     7080

ctgagcctgg gagctctctg gctaactagg gaacccactg cttaagcctc aataaagctt     7140

gccttgagtg cttcaagtag tgtgtgcccg tctgttgtgt gactctggta actagagatc     7200

cctcagaccc ttttagtcag tgtggaaaat ctctagcagg gcccgtttaa acccgctgat     7260

cagcctcgac tgtgccttct agttgccagc catctgttgt ttgcccctcc cccgtgcctt     7320

ccttgaccct ggaaggtgcc actcccactg tcctttccta ataaaatgag gaaattgcat     7380

cgcattgtct gagtaggtgt cattctattc tggggggtgg ggtggggcag gacagcaagg     7440

gggaggattg ggaagacaat agcaggcatg ctggggatgc ggtgggctct atggcttctg     7500

aggcggaaag aaccagctgg ggctctaggg ggtatcccca cgcgccctgt agcggcgcat     7560

taagcgcggc gggtgtggtg gttacgcgca gcgtgaccgc tacacttgcc agcgccctag     7620

cgcccgctcc tttcgctttc ttcccttcct ttctcgccac gttcgccggc tttccccgtc     7680

aagctctaaa tcgggggctc cctttagggt tccgatttag tgctttacgg cacctcgacc     7740

ccaaaaaact tgattagggt gatggttcac gtagtgggcc atcgccctga tagacggttt     7800

ttcgcccttt gacgttggag tccacgttct ttaatagtgg actcttgttc caaactggaa     7860

caacactcaa ccctatctcg gtctattctt ttgatttata agggattttg ccgatttcgg     7920

cctattggtt aaaaaatgag ctgatttaac aaaaatttaa cgcgaattaa ttctgtggaa     7980

tgtgtgtcag ttagggtgtg gaaagtcccc aggctcccca gcaggcagaa gtatgcaaag     8040

catgcatctc aattagtcag caaccaggtg tggaaagtcc ccaggctccc cagcaggcag     8100

aagtatgcaa agcatgcatc tcaattagtc agcaaccata gtcccgcccc taactccgcc     8160

catcccgccc ctaactccgc ccagttccgc ccattctccg ccccatggct gactaatttt     8220

ttttatttat gcagaggccg aggccgcctc tgcctctgag ctattccaga agtagtgagg     8280

aggctttttt ggaggcctag gcttttgcaa aaagctcccg ggagcttgta tatccatttt     8340

cggatctgat cagcacgtgt tgacaattaa tcatcggcat agtatatcgg catagtataa     8400

tacgacaagg tgaggaacta aaccatggcc aagttgacca gtgccgttcc ggtgctcacc     8460

gcgcgcgacg tcgccggagc ggtcgagttc tggaccgacc ggctcgggtt ctcccgggac     8520

ttcgtggagg acgacttcgc cggtgtggtc cgggacgacg tgaccctgtt catcagcgcg     8580

gtccaggacc aggtggtgcc ggacaacacc ctggcctggg tgtgggtgcg cggcctggac     8640

gagctgtacg ccgagtggtc ggaggtcgtg tccacgaact tccgggacgc ctccgggccg     8700

gccatgaccg agatcggcga gcagccgtgg gggcgggagt tcgccctgcg cgacccggcc     8760

ggcaactgcg tgcacttcgt ggccgaggag caggactgac acgtgctacg agatttcgat     8820

tccaccgccg ccttctatga aaggttgggc ttcggaatcg ttttccggga cgccggctgg     8880

atgatcctcc agcgcgggga tctcatgctg gagttcttcg cccaccccaa cttgtttatt     8940

gcagcttata atggttacaa ataaagcaat agcatcacaa atttcacaaa taaagcattt     9000

ttttcactgc attctagttg tggtttgtcc aaactcatca atgtatctta tcatgtctgt     9060

ataccgtcga cctctagcta gagcttggcg taatcatggt catagctgtt tcctgtgtga     9120

aattgttatc cgctcacaat tccacacaac atacgagccg gaagcataaa gtgtaaagcc     9180

tggggtgcct aatgagtgag ctaactcaca ttaattgcgt tgcgctcact gcccgctttc     9240

cagtcgggaa acctgtcgtg ccagctgcat taatgaatcg gccaacgcgc ggggagaggc     9300

ggtttgcgta ttgggcgctc ttccgcttcc tcgctcactg actcgctgcg ctcggtcgtt     9360

cggctgcggc gagcggtatc agctcactca aaggcggtaa tacggttatc cacagaatca     9420

ggggataacg caggaaagaa catgtgagca aaaggccagc aaaaggccag gaaccgtaaa     9480

aaggccgcgt tgctggcgtt tttccatagg ctccgccccc ctgacgagca tcacaaaaat     9540

cgacgctcaa gtcagaggtg gcgaaacccg acaggactat aaagatacca ggcgtttccc     9600

cctggaagct ccctcgtgcg ctctcctgtt ccgaccctgc cgcttaccgg atacctgtcc     9660

gcctttctcc cttcgggaag cgtggcgctt tctcatagct cacgctgtag gtatctcagt     9720

tcggtgtagg tcgttcgctc caagctgggc tgtgtgcacg aaccccccgt tcagcccgac     9780

cgctgcgcct tatccggtaa ctatcgtctt gagtccaacc cggtaagaca cgacttatcg     9840

ccactggcag cagccactgg taacaggatt agcagagcga ggtatgtagg cggtgctaca     9900

gagttcttga agtggtggcc taactacggc tacactagaa gaacagtatt tggtatctgc     9960

gctctgctga agccagttac cttcggaaaa agagttggta gctcttgatc cggcaaacaa    10020

accaccgctg gtagcggtgg tttttttgtt tgcaagcagc agattacgcg cagaaaaaaa    10080

ggatctcaag aagatccttt gatcttttct acggggtctg acgctcagtg gaacgaaaac    10140

tcacgttaag ggattttggt catgagatta tcaaaaagga tcttcaccta gatcctttta    10200

aattaaaaat gaagttttaa atcaatctaa agtatatatg agtaaacttg gtctgacagt    10260

taccaatgct taatcagtga ggcacctatc tcagcgatct gtctatttcg ttcatccata    10320

gttgcctgac tccccgtcgt gtagataact acgatacggg agggcttacc atctggcccc    10380

agtgctgcaa tgataccgcg agacccacgc tcaccggctc cagatttatc agcaataaac    10440

cagccagccg gaagggccga gcgcagaagt ggtcctgcaa ctttatccgc ctccatccag    10500

tctattaatt gttgccggga agctagagta agtagttcgc cagttaatag tttgcgcaac    10560

gttgttgcca ttgctacagg catcgtggtg tcacgctcgt cgtttggtat ggcttcattc    10620

agctccggtt cccaacgatc aaggcgagtt acatgatccc ccatgttgtg caaaaaagcg    10680

gttagctcct tcggtcctcc gatcgttgtc agaagtaagt tggccgcagt gttatcactc    10740

atggttatgg cagcactgca taattctctt actgtcatgc catccgtaag atgcttttct    10800

gtgactggtg agtactcaac caagtcattc tgagaatagt gtatgcggcg accgagttgc    10860

tcttgcccgg cgtcaatacg ggataatacc gcgccacata gcagaacttt aaaagtgctc    10920

atcattggaa aacgttcttc ggggcgaaaa ctctcaagga tcttaccgct gttgagatcc    10980

agttcgatgt aacccactcg tgcacccaac tgatcttcag catcttttac tttcaccagc    11040

gtttctgggt gagcaaaaac aggaaggcaa aatgccgcaa aaaagggaat aagggcgaca    11100

cggaaatgtt gaatactcat actcttcctt tttcaatatt attgaagcat ttatcagggt    11160

tattgtctca tgagcggata catatttgaa tgtatttaga aaaataaaca aataggggtt    11220

ccgcgcacat ttccccgaaa agtgccacct gac                                 11253


<210>  686
<211>  11364
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Synthetic nucleotide

<400>  686
gtcgacggat cgggagatct cccgatcccc tatggtgcac tctcagtaca atctgctctg       60

atgccgcata gttaagccag tatctgctcc ctgcttgtgt gttggaggtc gctgagtagt      120

gcgcgagcaa aatttaagct acaacaaggc aaggcttgac cgacaattgc atgaagaatc      180

tgcttagggt taggcgtttt gcgctgcttc gcgatgtacg ggccagatat acgcgttgac      240

attgattatt gactagttat taatagtaat caattacggg gtcattagtt catagcccat      300

atatggagtt ccgcgttaca taacttacgg taaatggccc gcctggctga ccgcccaacg      360

acccccgccc attgacgtca ataatgacgt atgttcccat agtaacgcca atagggactt      420

tccattgacg tcaatgggtg gagtatttac ggtaaactgc ccacttggca gtacatcaag      480

tgtatcatat gccaagtacg ccccctattg acgtcaatga cggtaaatgg cccgcctggc      540

attatgccca gtacatgacc ttatgggact ttcctacttg gcagtacatc tacgtattag      600

tcatcgctat taccatggtg atgcggtttt ggcagtacat caatgggcgt ggatagcggt      660

ttgactcacg gggatttcca agtctccacc ccattgacgt caatgggagt ttgttttggc      720

accaaaatca acgggacttt ccaaaatgtc gtaacaactc cgccccattg acgcaaatgg      780

gcggtaggcg tgtacggtgg gaggtctata taagcagcgc gttttgcctg tactgggtct      840

ctctggttag accagatctg agcctgggag ctctctggct aactagggaa cccactgctt      900

aagcctcaat aaagcttgcc ttgagtgctt caagtagtgt gtgcccgtct gttgtgtgac      960

tctggtaact agagatccct cagacccttt tagtcagtgt ggaaaatctc tagcagtggc     1020

gcccgaacag ggacttgaaa gcgaaaggga aaccagagga gctctctcga cgcaggactc     1080

ggcttgctga agcgcgcacg gcaagaggcg aggggcggcg actggtgagt acgccaaaaa     1140

ttttgactag cggaggctag aaggagagag atgggtgcga gagcgtcagt attaagcggg     1200

ggagaattag atcgcgatgg gaaaaaattc ggttaaggcc agggggaaag aaaaaatata     1260

aattaaaaca tatagtatgg gcaagcaggg agctagaacg attcgcagtt aatcctggcc     1320

tgttagaaac atcagaaggc tgtagacaaa tactgggaca gctacaacca tcccttcaga     1380

caggatcaga agaacttaga tcattatata atacagtagc aaccctctat tgtgtgcatc     1440

aaaggataga gataaaagac accaaggaag ctttagacaa gatagaggaa gagcaaaaca     1500

aaagtaagac caccgcacag caagcggccg ctgatcttca gacctggagg aggagatatg     1560

agggacaatt ggagaagtga attatataaa tataaagtag taaaaattga accattagga     1620

gtagcaccca ccaaggcaaa gagaagagtg gtgcagagag aaaaaagagc agtgggaata     1680

ggagctttgt tccttgggtt cttgggagca gcaggaagca ctatgggcgc agcgtcaatg     1740

acgctgacgg tacaggccag acaattattg tctggtatag tgcagcagca gaacaatttg     1800

ctgagggcta ttgaggcgca acagcatctg ttgcaactca cagtctgggg catcaagcag     1860

ctccaggcaa gaatcctggc tgtggaaaga tacctaaagg atcaacagct cctggggatt     1920

tggggttgct ctggaaaact catttgcacc actgctgtgc cttggaatgc tagttggagt     1980

aataaatctc tggaacagat ttggaatcac acgacctgga tggagtggga cagagaaatt     2040

aacaattaca caagcttaat acactcctta attgaagaat cgcaaaacca gcaagaaaag     2100

aatgaacaag aattattgga attagataaa tgggcaagtt tgtggaattg gtttaacata     2160

acaaattggc tgtggtatat aaaattattc ataatgatag taggaggctt ggtaggttta     2220

agaatagttt ttgctgtact ttctatagtg aatagagtta ggcagggata ttcaccatta     2280

tcgtttcaga cccacctccc aaccccgagg ggacccgaca ggcccgaagg aatagaagaa     2340

gaaggtggag agagagacag agacagatcc attcgattag tgaacggatc ggcactgcgt     2400

gcgccaattc tgcagacaaa tggcagtatt catccacaat tttaaaagaa aaggggggat     2460

tggggggtac agtgcagggg aaagaatagt agacataata gcaacagaca tacaaactaa     2520

agaattacaa aaacaaatta caaaaattca aaattttcgg gtttattaca gggacagcag     2580

agatccagtt tggttaatta gctagctagg tcttgaaagg agtgggaatt ggctccggtg     2640

cccgtcagtg ggcagagcgc acatcgccca cagtccccga gaagttgggg ggaggggtcg     2700

gcaattgatc cggtgcctag agaaggtggc gcggggtaaa ctgggaaagt gatgtcgtgt     2760

actggctccg cctttttccc gagggtgggg gagaaccgta tataagtgca gtagtcgccg     2820

tgaacgttct ttttcgcaac gggtttgccg ccagaacaca ggaccggttc tagagcgctt     2880

taattaagcc accatggccc tgccagtgac agccctgctt ctgcctctgg ctctgctgct     2940

ccacgccgcc agacccagct acgtgctcac acagcctcct tctgtgagcg tggccccagg     3000

acagacagcc agaatcacct gtggcggcaa caacatcggc agaaagatcg tgcactggta     3060

tcagcaaaga cctggccagg cccctgtgct ggtgatctac tacgatactg atcggcccgc     3120

cggcatccct gagcggtttt ctggctctaa ctccggaaat atggcaacac tgacaatcag     3180

cacagtgggc gccggagacg aagctgacta ctactgccag gtgtgggata ctggctcgga     3240

ccacgtggtt ttcggcggcg gcaccaagct gaccgtcctg ggcggcggtg gttcgggcgg     3300

cggcggctct ggcggcggcg gctctggcgg aggcggcagc gaggtgcagc tggttgaaag     3360

cggcggcggt ctggtgcagc ctggaggctc cttacggctg tcctgcgccg ccagcggctt     3420

cactttcagc aactacgcca tgagctgggt ccggcaggcc cctggaaaag gcctggaatg     3480

ggtgagcacc atcagcggaa gcggcgggac cacctattac gccgacagcg tgaagggcag     3540

atttaccatc agcagggaca atagcaagaa taccctgtac ctgcagatga acagcctgcg     3600

agtggaggac acagccgtct actactgcgc caaggactgg ttcagaagca gctctcctga     3660

cgccttcgac atctggggcc agggcaccac cgtgactgtc agcgccgaca tggccgacat     3720

ccctggccac gtgtttacca gaggcatgat catcgccgtg ctgattctgg tggccgtggt     3780

ttgtctggtg accgtgtgcg tgatctaccg ggtggacctg gtgctgttct accggcatct     3840

gacaagaagg gacgaaacct tgacggacgg caagacatac gacgcattcg tgtcttacct     3900

gaaggagtgc agacccgaga acggcgaaga acacaccttt gccgtggaaa tcctgcctag     3960

agtgctggaa aagcacttcg gctacaagct gtgcatcttc gagagagatg ttgtgcccgg     4020

cggagctgtc gtggatgaga tacacagtct gatcgagaaa agcagaagac tgattatcgt     4080

gctctccaag agctatatga gcaacgaggt gagatacgag ctggagagcg gtctccacga     4140

ggctctggtc gaacggaaga tcaagattat tctgatcgag ttcacccctg ttacagactt     4200

caccttcctg cctcagagcc tgaagttact gaagagtcac agagtgctga agtggaaagc     4260

tgataagagc ctgagctaca acagccgctt ctggaagaat ctgctctacc tgatgcctgc     4320

caaaacagtg aagcctggca gggatgagcc tgaggtgctg cccgtgctgt ctgaaagcgg     4380

ctccggggag ggcagaggct ccctgctgac ctgcggcgac gtggaagaga accccggacc     4440

tatggctctg ccagtgaccg ctctgctgct gcctctggcc ctgctgctgc atgccgccag     4500

gcctaacttc atgctgaccc aacctcacag cgtgtcggag tctctgggca agaccgtgac     4560

aatcagctgc accggaagct ctggcagcat cgcccgtaaa ttcgtgcagt ggtatcagca     4620

gaggccgggc tcatccccta ccaccgtgat ctacgagaac aaccagcggc ctagcggcgt     4680

gagcgacaga ttcagcggaa gcatcggaag cagcagcaat agcgcctcac tgaccatcag     4740

cggcctgaaa accgaggacg aagccgacta ctactgtcag agctacgact ccagcaacgt     4800

ggttttcggc ggcggaacaa aggtgaccgt gctgggcggc ggcggatctg gtggcggcgg     4860

ctccggcgga ggcggctctg ggggcggcgg tagccaagtg cagctgcagg agagcggagg     4920

cggcctggtg aagccaggcg gctccctgag actgagctgt gccgctagtg gctttacctt     4980

tagcagttac agcatgaact gggtgagaca ggcccccggc aagggactgg aatgggtgtc     5040

aggcatcaac accgctggcg atacacacta ccccgagagc gtgaaaggca gattcacaat     5100

cagcagagat aacgccagaa acagcctgaa cctgcagatg aatagcttgc gggccgagga     5160

caccgccgtg tactactgcg tgcgggaacg ggtggaaaga gagtactcgg gatacgacgc     5220

cttcgacatc tggggacagg gaaccacagt gacagtgtcc gccaacacga cccagagcgt     5280

acaactcaaa gaaaagcggg gagtggtcct gctgtatatc ctgctcggca ctatcggcac     5340

cctggtggcc gtcctggccg ccagcgccct gctgtataga cactggattg agatcgtgct     5400

cctgtacaga acctaccaga gcaaagacca gacgctgggc gacaagaagg atttcgacgc     5460

ctttgtgagc tacgccaaat ggtcctcctt ccctagcgag gccacatcta gtctgtctga     5520

ggaacacctg gccctgtccc ttttccccga tgtgctggag aacaagtacg gctacagcct     5580

gtgcctgctg gaacgggatg tggctcctgg aggcgtgtac gccgaagaca tcgtgtctat     5640

catcaaaaga agccggagag gcatcttcat cctgtctcca aactacgtga acggccctag     5700

catcttcgag ctgcaagcgg ctgttaactt ggctctggac gaccagaccc tgaagctgat     5760

cctgatcaag ttctgctact tccaggagcc tgagtccctg ccccacctgg tgaagaaggc     5820

cctcagagtg ctcccaaccg ttacatggcg gggcctgaag agcgtgcccc ccaactccag     5880

attttgggcc aagatgagat accacatgcc tgtgaagaat agccaaggct tcacctggaa     5940

ccagctgcgg atcaccagcc gtatcttcca gtggaagggc ctgtctagga ccgagacaac     6000

cggcagatct agccagccta aggaatggtg agaattcgat atcaagctta tcggtaatca     6060

acctctggat tacaaaattt gtgaaagatt gactggtatt cttaactatg ttgctccttt     6120

tacgctatgt ggatacgctg ctttaatgcc tttgtatcat gctattgctt cccgtatggc     6180

tttcattttc tcctccttgt ataaatcctg gttgctgtct ctttatgagg agttgtggcc     6240

cgttgtcagg caacgtggcg tggtgtgcac tgtgtttgct gacgcaaccc ccactggttg     6300

gggcattgcc accacctgtc agctcctttc cgggactttc gctttccccc tccctattgc     6360

cacggcggaa ctcatcgccg cctgccttgc ccgctgctgg acaggggctc ggctgttggg     6420

cactgacaat tccgtggtgt tgtcggggaa atcatcgtcc tttccttggc tgctcgcctg     6480

tgttgccacc tggattctgc gcgggacgtc cttctgctac gtcccttcgg ccctcaatcc     6540

agcggacctt ccttcccgcg gcctgctgcc ggctctgcgg cctcttccgc gtcttcgcct     6600

tcgccctcag acgagtcgga tctccctttg ggccgcctcc ccgcatcgat accgtcgacc     6660

tcgagaccta gaaaaacatg gagcaatcac aagtagcaat acagcagcta ccaatgctga     6720

ttgtgcctgg ctagaagcac aagaggagga ggaggtgggt tttccagtca cacctcaggt     6780

acctttaaga ccaatgactt acaaggcagc tgtagatctt agccactttt taaaagaaaa     6840

ggggggactg gaagggctaa ttcactccca acgaagacaa gatatccttg atctgtggat     6900

ctaccacaca caaggctact tccctgattg gcagaactac acaccagggc cagggatcag     6960

atatccactg acctttggat ggtgctacaa gctagtacca gttgagcaag agaaggtaga     7020

agaagccaat gaaggagaga acacccgctt gttacaccct gtgagcctgc atgggatgga     7080

tgacccggag agagaagtat tagagtggag gtttgacagc cgcctagcat ttcatcacat     7140

ggcccgagag ctgcatccgg actgtactgg gtctctctgg ttagaccaga tctgagcctg     7200

ggagctctct ggctaactag ggaacccact gcttaagcct caataaagct tgccttgagt     7260

gcttcaagta gtgtgtgccc gtctgttgtg tgactctggt aactagagat ccctcagacc     7320

cttttagtca gtgtggaaaa tctctagcag ggcccgttta aacccgctga tcagcctcga     7380

ctgtgccttc tagttgccag ccatctgttg tttgcccctc ccccgtgcct tccttgaccc     7440

tggaaggtgc cactcccact gtcctttcct aataaaatga ggaaattgca tcgcattgtc     7500

tgagtaggtg tcattctatt ctggggggtg gggtggggca ggacagcaag ggggaggatt     7560

gggaagacaa tagcaggcat gctggggatg cggtgggctc tatggcttct gaggcggaaa     7620

gaaccagctg gggctctagg gggtatcccc acgcgccctg tagcggcgca ttaagcgcgg     7680

cgggtgtggt ggttacgcgc agcgtgaccg ctacacttgc cagcgcccta gcgcccgctc     7740

ctttcgcttt cttcccttcc tttctcgcca cgttcgccgg ctttccccgt caagctctaa     7800

atcgggggct ccctttaggg ttccgattta gtgctttacg gcacctcgac cccaaaaaac     7860

ttgattaggg tgatggttca cgtagtgggc catcgccctg atagacggtt tttcgccctt     7920

tgacgttgga gtccacgttc tttaatagtg gactcttgtt ccaaactgga acaacactca     7980

accctatctc ggtctattct tttgatttat aagggatttt gccgatttcg gcctattggt     8040

taaaaaatga gctgatttaa caaaaattta acgcgaatta attctgtgga atgtgtgtca     8100

gttagggtgt ggaaagtccc caggctcccc agcaggcaga agtatgcaaa gcatgcatct     8160

caattagtca gcaaccaggt gtggaaagtc cccaggctcc ccagcaggca gaagtatgca     8220

aagcatgcat ctcaattagt cagcaaccat agtcccgccc ctaactccgc ccatcccgcc     8280

cctaactccg cccagttccg cccattctcc gccccatggc tgactaattt tttttattta     8340

tgcagaggcc gaggccgcct ctgcctctga gctattccag aagtagtgag gaggcttttt     8400

tggaggccta ggcttttgca aaaagctccc gggagcttgt atatccattt tcggatctga     8460

tcagcacgtg ttgacaatta atcatcggca tagtatatcg gcatagtata atacgacaag     8520

gtgaggaact aaaccatggc caagttgacc agtgccgttc cggtgctcac cgcgcgcgac     8580

gtcgccggag cggtcgagtt ctggaccgac cggctcgggt tctcccggga cttcgtggag     8640

gacgacttcg ccggtgtggt ccgggacgac gtgaccctgt tcatcagcgc ggtccaggac     8700

caggtggtgc cggacaacac cctggcctgg gtgtgggtgc gcggcctgga cgagctgtac     8760

gccgagtggt cggaggtcgt gtccacgaac ttccgggacg cctccgggcc ggccatgacc     8820

gagatcggcg agcagccgtg ggggcgggag ttcgccctgc gcgacccggc cggcaactgc     8880

gtgcacttcg tggccgagga gcaggactga cacgtgctac gagatttcga ttccaccgcc     8940

gccttctatg aaaggttggg cttcggaatc gttttccggg acgccggctg gatgatcctc     9000

cagcgcgggg atctcatgct ggagttcttc gcccacccca acttgtttat tgcagcttat     9060

aatggttaca aataaagcaa tagcatcaca aatttcacaa ataaagcatt tttttcactg     9120

cattctagtt gtggtttgtc caaactcatc aatgtatctt atcatgtctg tataccgtcg     9180

acctctagct agagcttggc gtaatcatgg tcatagctgt ttcctgtgtg aaattgttat     9240

ccgctcacaa ttccacacaa catacgagcc ggaagcataa agtgtaaagc ctggggtgcc     9300

taatgagtga gctaactcac attaattgcg ttgcgctcac tgcccgcttt ccagtcggga     9360

aacctgtcgt gccagctgca ttaatgaatc ggccaacgcg cggggagagg cggtttgcgt     9420

attgggcgct cttccgcttc ctcgctcact gactcgctgc gctcggtcgt tcggctgcgg     9480

cgagcggtat cagctcactc aaaggcggta atacggttat ccacagaatc aggggataac     9540

gcaggaaaga acatgtgagc aaaaggccag caaaaggcca ggaaccgtaa aaaggccgcg     9600

ttgctggcgt ttttccatag gctccgcccc cctgacgagc atcacaaaaa tcgacgctca     9660

agtcagaggt ggcgaaaccc gacaggacta taaagatacc aggcgtttcc ccctggaagc     9720

tccctcgtgc gctctcctgt tccgaccctg ccgcttaccg gatacctgtc cgcctttctc     9780

ccttcgggaa gcgtggcgct ttctcatagc tcacgctgta ggtatctcag ttcggtgtag     9840

gtcgttcgct ccaagctggg ctgtgtgcac gaaccccccg ttcagcccga ccgctgcgcc     9900

ttatccggta actatcgtct tgagtccaac ccggtaagac acgacttatc gccactggca     9960

gcagccactg gtaacaggat tagcagagcg aggtatgtag gcggtgctac agagttcttg    10020

aagtggtggc ctaactacgg ctacactaga agaacagtat ttggtatctg cgctctgctg    10080

aagccagtta ccttcggaaa aagagttggt agctcttgat ccggcaaaca aaccaccgct    10140

ggtagcggtg gtttttttgt ttgcaagcag cagattacgc gcagaaaaaa aggatctcaa    10200

gaagatcctt tgatcttttc tacggggtct gacgctcagt ggaacgaaaa ctcacgttaa    10260

gggattttgg tcatgagatt atcaaaaagg atcttcacct agatcctttt aaattaaaaa    10320

tgaagtttta aatcaatcta aagtatatat gagtaaactt ggtctgacag ttaccaatgc    10380

ttaatcagtg aggcacctat ctcagcgatc tgtctatttc gttcatccat agttgcctga    10440

ctccccgtcg tgtagataac tacgatacgg gagggcttac catctggccc cagtgctgca    10500

atgataccgc gagacccacg ctcaccggct ccagatttat cagcaataaa ccagccagcc    10560

ggaagggccg agcgcagaag tggtcctgca actttatccg cctccatcca gtctattaat    10620

tgttgccggg aagctagagt aagtagttcg ccagttaata gtttgcgcaa cgttgttgcc    10680

attgctacag gcatcgtggt gtcacgctcg tcgtttggta tggcttcatt cagctccggt    10740

tcccaacgat caaggcgagt tacatgatcc cccatgttgt gcaaaaaagc ggttagctcc    10800

ttcggtcctc cgatcgttgt cagaagtaag ttggccgcag tgttatcact catggttatg    10860

gcagcactgc ataattctct tactgtcatg ccatccgtaa gatgcttttc tgtgactggt    10920

gagtactcaa ccaagtcatt ctgagaatag tgtatgcggc gaccgagttg ctcttgcccg    10980

gcgtcaatac gggataatac cgcgccacat agcagaactt taaaagtgct catcattgga    11040

aaacgttctt cggggcgaaa actctcaagg atcttaccgc tgttgagatc cagttcgatg    11100

taacccactc gtgcacccaa ctgatcttca gcatctttta ctttcaccag cgtttctggg    11160

tgagcaaaaa caggaaggca aaatgccgca aaaaagggaa taagggcgac acggaaatgt    11220

tgaatactca tactcttcct ttttcaatat tattgaagca tttatcaggg ttattgtctc    11280

atgagcggat acatatttga atgtatttag aaaaataaac aaataggggt tccgcgcaca    11340

tttccccgaa aagtgccacc tgac                                           11364


<210>  687
<211>  11268
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Synthetic nucleotide

<400>  687
gtcgacggat cgggagatct cccgatcccc tatggtgcac tctcagtaca atctgctctg       60

atgccgcata gttaagccag tatctgctcc ctgcttgtgt gttggaggtc gctgagtagt      120

gcgcgagcaa aatttaagct acaacaaggc aaggcttgac cgacaattgc atgaagaatc      180

tgcttagggt taggcgtttt gcgctgcttc gcgatgtacg ggccagatat acgcgttgac      240

attgattatt gactagttat taatagtaat caattacggg gtcattagtt catagcccat      300

atatggagtt ccgcgttaca taacttacgg taaatggccc gcctggctga ccgcccaacg      360

acccccgccc attgacgtca ataatgacgt atgttcccat agtaacgcca atagggactt      420

tccattgacg tcaatgggtg gagtatttac ggtaaactgc ccacttggca gtacatcaag      480

tgtatcatat gccaagtacg ccccctattg acgtcaatga cggtaaatgg cccgcctggc      540

attatgccca gtacatgacc ttatgggact ttcctacttg gcagtacatc tacgtattag      600

tcatcgctat taccatggtg atgcggtttt ggcagtacat caatgggcgt ggatagcggt      660

ttgactcacg gggatttcca agtctccacc ccattgacgt caatgggagt ttgttttggc      720

accaaaatca acgggacttt ccaaaatgtc gtaacaactc cgccccattg acgcaaatgg      780

gcggtaggcg tgtacggtgg gaggtctata taagcagcgc gttttgcctg tactgggtct      840

ctctggttag accagatctg agcctgggag ctctctggct aactagggaa cccactgctt      900

aagcctcaat aaagcttgcc ttgagtgctt caagtagtgt gtgcccgtct gttgtgtgac      960

tctggtaact agagatccct cagacccttt tagtcagtgt ggaaaatctc tagcagtggc     1020

gcccgaacag ggacttgaaa gcgaaaggga aaccagagga gctctctcga cgcaggactc     1080

ggcttgctga agcgcgcacg gcaagaggcg aggggcggcg actggtgagt acgccaaaaa     1140

ttttgactag cggaggctag aaggagagag atgggtgcga gagcgtcagt attaagcggg     1200

ggagaattag atcgcgatgg gaaaaaattc ggttaaggcc agggggaaag aaaaaatata     1260

aattaaaaca tatagtatgg gcaagcaggg agctagaacg attcgcagtt aatcctggcc     1320

tgttagaaac atcagaaggc tgtagacaaa tactgggaca gctacaacca tcccttcaga     1380

caggatcaga agaacttaga tcattatata atacagtagc aaccctctat tgtgtgcatc     1440

aaaggataga gataaaagac accaaggaag ctttagacaa gatagaggaa gagcaaaaca     1500

aaagtaagac caccgcacag caagcggccg ctgatcttca gacctggagg aggagatatg     1560

agggacaatt ggagaagtga attatataaa tataaagtag taaaaattga accattagga     1620

gtagcaccca ccaaggcaaa gagaagagtg gtgcagagag aaaaaagagc agtgggaata     1680

ggagctttgt tccttgggtt cttgggagca gcaggaagca ctatgggcgc agcgtcaatg     1740

acgctgacgg tacaggccag acaattattg tctggtatag tgcagcagca gaacaatttg     1800

ctgagggcta ttgaggcgca acagcatctg ttgcaactca cagtctgggg catcaagcag     1860

ctccaggcaa gaatcctggc tgtggaaaga tacctaaagg atcaacagct cctggggatt     1920

tggggttgct ctggaaaact catttgcacc actgctgtgc cttggaatgc tagttggagt     1980

aataaatctc tggaacagat ttggaatcac acgacctgga tggagtggga cagagaaatt     2040

aacaattaca caagcttaat acactcctta attgaagaat cgcaaaacca gcaagaaaag     2100

aatgaacaag aattattgga attagataaa tgggcaagtt tgtggaattg gtttaacata     2160

acaaattggc tgtggtatat aaaattattc ataatgatag taggaggctt ggtaggttta     2220

agaatagttt ttgctgtact ttctatagtg aatagagtta ggcagggata ttcaccatta     2280

tcgtttcaga cccacctccc aaccccgagg ggacccgaca ggcccgaagg aatagaagaa     2340

gaaggtggag agagagacag agacagatcc attcgattag tgaacggatc ggcactgcgt     2400

gcgccaattc tgcagacaaa tggcagtatt catccacaat tttaaaagaa aaggggggat     2460

tggggggtac agtgcagggg aaagaatagt agacataata gcaacagaca tacaaactaa     2520

agaattacaa aaacaaatta caaaaattca aaattttcgg gtttattaca gggacagcag     2580

agatccagtt tggttaatta gctagctagg tcttgaaagg agtgggaatt ggctccggtg     2640

cccgtcagtg ggcagagcgc acatcgccca cagtccccga gaagttgggg ggaggggtcg     2700

gcaattgatc cggtgcctag agaaggtggc gcggggtaaa ctgggaaagt gatgtcgtgt     2760

actggctccg cctttttccc gagggtgggg gagaaccgta tataagtgca gtagtcgccg     2820

tgaacgttct ttttcgcaac gggtttgccg ccagaacaca ggaccggttc tagagcgctt     2880

taattaagcc accatggccc tgcctgtgac agcgctgctg ctgccactgg ccctgcttct     2940

gcacgccgcc agaccccaga tccagctggt gcagtcaggc cctgaactga agaagcctgg     3000

agagacagtg aagattagct gcaaggcctc gggatacacc ttcacaaact atggcatgaa     3060

ctgggtcaaa caggcccctg gcaagggcct taaatggatg ggctggatca acacaaagac     3120

cggcgaaccc acctacgccg aggagttcaa gggcagattc gccttttctc tggagacatc     3180

cgccagcacc gcctacctgc agatcaacaa cctgaaaaag gaagatacag ccacatactt     3240

ctgcggacgg ggcggatacg gtagcagcta ctggtacttc gacgtgtggg gcgccggaac     3300

cacagtgacc gtttcgtctg ccagcacaaa aggcccttcc ggcggcggag gctccggcgg     3360

cgggggcagt ggcggcggcg gctctggcgg cggaggcagc gacatcgtga tgacccagag     3420

ccacaagttc atgagcacca gcgtgggcga ccgggtgtcg atcacctgca aggccagtca     3480

ggatgtgagc atcgccgtcg cctggtatca gcaaaagccc ggccaaagcc ctaaggtgct     3540

gatctatagc gcctcctaca gatacaccgg cgttcctgac agattcacag ggtctggcag     3600

cggcaccgat ttcaccttca caatctccag agtgcaggcc gaggacctgg ccgtgtacta     3660

ctgccagcag cactacatca cacctctgac ctttggtgct ggcacaaagc tggaactgaa     3720

aagaaccgtg gccttcagaa ctaagcctgc tgccctcggc aaggacacca tcccttggct     3780

gggccacctg ctggtgggcc tgagcggagc ttttggcttc atcatcctgg tctacctgct     3840

gattaactgc agaaacaccg gtccttggct gaagaaagtg ctgaagtgca acacccccga     3900

ccctagcaag ttcttcagcc agctgagcag cgagcacggc ggggacgtgc aaaaatggct     3960

gagcagcccc ttcccatctt ccagcttcag ccctggcggc ctggctcctg agatcagccc     4020

cctggaagtg ctggaacggg ataaggtgac ccagctgtta ctccagcagg acaaggtgcc     4080

cgaacctgcc agcctgagca gcaaccacag cctgactagc tgcttcacca accagggcta     4140

cttcttcttt cacctgcccg acgccctgga gatcgaggcc tgccaggtgt acttcaccta     4200

cgacccttac agcgaggagg accctgacga gggcgtggcc ggggctccta ccggctcgtc     4260

tcctcagcct ttgcagcctc tgagcggaga ggatgacgcc tattgcacct ttcctagcag     4320

agatgatctg ctgctcttca gcccttctct gctgggcgga ccaagcccac cttctaccgc     4380

acctggcggc tctggcgcag gcgaagagcg gatgcctcct tctctgcagg agagagtgcc     4440

ccgggactgg gaccctcagc cgctgggacc tcctacccct ggcgtgccgg atctggtgga     4500

ctttcagcca ccacctgagc tggtgctgag agaagccggc gaagaggtgc ctgacgccgg     4560

ccctagggag ggcgtgagct tcccttggag ccggcctcct ggacaaggcg agttccgcgc     4620

cctgaacgcc agactgcccc tgaacaccga cgcctacctg agcctgcagg agctgcaggg     4680

ccaggacccc acccacctgg tgggcagcgg agagggaaga ggcagcctgt tgacatgtgg     4740

cgatgtcgag gaaaaccctg ggcctatggc cctgccagtg acagcactac tcctgcctct     4800

ggccctgctg ctccacgccg ccagacctca ggtgcagctg cagcaatctg gccccgagct     4860

agtgcggcct ggcaccagcg tgcggatttc ctgcaaggcc tctggctaca ccttcacaat     4920

ctattggctg ggctgggtga agcagagacc tggacatggg ctggagtgga taggaaacat     4980

cttccctggc tcagcttaca tcaactacaa cgagaagttt aagggaaaag ccaccctgac     5040

agccgacacc agcagcagca ccgcctatat gcagctgtct agcctgacat ctgaggatag     5100

cgccgtttac ttctgcgcca gagaaggctc caattctggc tactggggcc agggcacaac     5160

cttaaccgtg tccagcggag gaggcggctc tggcggcggc ggttcaggcg ggggcggaag     5220

cggcggtgga ggctctgaca ttgtgatgac ccagagcccc agcagcctga gcgtgtctgc     5280

tggcgagaag gtgaccatga cctgtaaatc tagccagagc ctgctgaaca gcggcaacca     5340

gcagaactac ctggcctggt atcagcagaa acctggccag ccccccaagc tgctgatcta     5400

cggcgccagc accagagaaa gcggcgtgcc tgacagattc actggcagcg gcagcggcac     5460

agacttcacc ctgaccatca atagcgtgca ggccgaagat ctggctgtgt actactgtca     5520

gagcgaccac atctaccctt acaccttcgg cggaggcacc aagctagaaa tcaagagcaa     5580

ggaaaatcca tttctgtttg ccctggaagc cgtggtgatc agcgtgggaa gcatgggcct     5640

gatcatctcg ctgctgtgcg tgtacttctg gctggaaagg accatgcccc gcatccctac     5700

cctcaagaac ctggaggacc tggtcacaga gtaccacggc aatttcagcg cctggtccgg     5760

cgtgtccaag ggcctggccg agagcctgca acccgattac agtgaacggc tgtgtctggt     5820

gtctgagatc cccccgaagg gaggcgccct gggagaaggc ccaggcgcca gcccttgtaa     5880

tcagcatagc ccttactggg ctcctccatg ttacaccctg aagcccgaaa cctgagaatt     5940

cgatatcaag cttatcggta atcaacctct ggattacaaa atttgtgaaa gattgactgg     6000

tattcttaac tatgttgctc cttttacgct atgtggatac gctgctttaa tgcctttgta     6060

tcatgctatt gcttcccgta tggctttcat tttctcctcc ttgtataaat cctggttgct     6120

gtctctttat gaggagttgt ggcccgttgt caggcaacgt ggcgtggtgt gcactgtgtt     6180

tgctgacgca acccccactg gttggggcat tgccaccacc tgtcagctcc tttccgggac     6240

tttcgctttc cccctcccta ttgccacggc ggaactcatc gccgcctgcc ttgcccgctg     6300

ctggacaggg gctcggctgt tgggcactga caattccgtg gtgttgtcgg ggaaatcatc     6360

gtcctttcct tggctgctcg cctgtgttgc cacctggatt ctgcgcggga cgtccttctg     6420

ctacgtccct tcggccctca atccagcgga ccttccttcc cgcggcctgc tgccggctct     6480

gcggcctctt ccgcgtcttc gccttcgccc tcagacgagt cggatctccc tttgggccgc     6540

ctccccgcat cgataccgtc gacctcgaga cctagaaaaa catggagcaa tcacaagtag     6600

caatacagca gctaccaatg ctgattgtgc ctggctagaa gcacaagagg aggaggaggt     6660

gggttttcca gtcacacctc aggtaccttt aagaccaatg acttacaagg cagctgtaga     6720

tcttagccac tttttaaaag aaaagggggg actggaaggg ctaattcact cccaacgaag     6780

acaagatatc cttgatctgt ggatctacca cacacaaggc tacttccctg attggcagaa     6840

ctacacacca gggccaggga tcagatatcc actgaccttt ggatggtgct acaagctagt     6900

accagttgag caagagaagg tagaagaagc caatgaagga gagaacaccc gcttgttaca     6960

ccctgtgagc ctgcatggga tggatgaccc ggagagagaa gtattagagt ggaggtttga     7020

cagccgccta gcatttcatc acatggcccg agagctgcat ccggactgta ctgggtctct     7080

ctggttagac cagatctgag cctgggagct ctctggctaa ctagggaacc cactgcttaa     7140

gcctcaataa agcttgcctt gagtgcttca agtagtgtgt gcccgtctgt tgtgtgactc     7200

tggtaactag agatccctca gaccctttta gtcagtgtgg aaaatctcta gcagggcccg     7260

tttaaacccg ctgatcagcc tcgactgtgc cttctagttg ccagccatct gttgtttgcc     7320

cctcccccgt gccttccttg accctggaag gtgccactcc cactgtcctt tcctaataaa     7380

atgaggaaat tgcatcgcat tgtctgagta ggtgtcattc tattctgggg ggtggggtgg     7440

ggcaggacag caagggggag gattgggaag acaatagcag gcatgctggg gatgcggtgg     7500

gctctatggc ttctgaggcg gaaagaacca gctggggctc tagggggtat ccccacgcgc     7560

cctgtagcgg cgcattaagc gcggcgggtg tggtggttac gcgcagcgtg accgctacac     7620

ttgccagcgc cctagcgccc gctcctttcg ctttcttccc ttcctttctc gccacgttcg     7680

ccggctttcc ccgtcaagct ctaaatcggg ggctcccttt agggttccga tttagtgctt     7740

tacggcacct cgaccccaaa aaacttgatt agggtgatgg ttcacgtagt gggccatcgc     7800

cctgatagac ggtttttcgc cctttgacgt tggagtccac gttctttaat agtggactct     7860

tgttccaaac tggaacaaca ctcaacccta tctcggtcta ttcttttgat ttataaggga     7920

ttttgccgat ttcggcctat tggttaaaaa atgagctgat ttaacaaaaa tttaacgcga     7980

attaattctg tggaatgtgt gtcagttagg gtgtggaaag tccccaggct ccccagcagg     8040

cagaagtatg caaagcatgc atctcaatta gtcagcaacc aggtgtggaa agtccccagg     8100

ctccccagca ggcagaagta tgcaaagcat gcatctcaat tagtcagcaa ccatagtccc     8160

gcccctaact ccgcccatcc cgcccctaac tccgcccagt tccgcccatt ctccgcccca     8220

tggctgacta atttttttta tttatgcaga ggccgaggcc gcctctgcct ctgagctatt     8280

ccagaagtag tgaggaggct tttttggagg cctaggcttt tgcaaaaagc tcccgggagc     8340

ttgtatatcc attttcggat ctgatcagca cgtgttgaca attaatcatc ggcatagtat     8400

atcggcatag tataatacga caaggtgagg aactaaacca tggccaagtt gaccagtgcc     8460

gttccggtgc tcaccgcgcg cgacgtcgcc ggagcggtcg agttctggac cgaccggctc     8520

gggttctccc gggacttcgt ggaggacgac ttcgccggtg tggtccggga cgacgtgacc     8580

ctgttcatca gcgcggtcca ggaccaggtg gtgccggaca acaccctggc ctgggtgtgg     8640

gtgcgcggcc tggacgagct gtacgccgag tggtcggagg tcgtgtccac gaacttccgg     8700

gacgcctccg ggccggccat gaccgagatc ggcgagcagc cgtgggggcg ggagttcgcc     8760

ctgcgcgacc cggccggcaa ctgcgtgcac ttcgtggccg aggagcagga ctgacacgtg     8820

ctacgagatt tcgattccac cgccgccttc tatgaaaggt tgggcttcgg aatcgttttc     8880

cgggacgccg gctggatgat cctccagcgc ggggatctca tgctggagtt cttcgcccac     8940

cccaacttgt ttattgcagc ttataatggt tacaaataaa gcaatagcat cacaaatttc     9000

acaaataaag catttttttc actgcattct agttgtggtt tgtccaaact catcaatgta     9060

tcttatcatg tctgtatacc gtcgacctct agctagagct tggcgtaatc atggtcatag     9120

ctgtttcctg tgtgaaattg ttatccgctc acaattccac acaacatacg agccggaagc     9180

ataaagtgta aagcctgggg tgcctaatga gtgagctaac tcacattaat tgcgttgcgc     9240

tcactgcccg ctttccagtc gggaaacctg tcgtgccagc tgcattaatg aatcggccaa     9300

cgcgcgggga gaggcggttt gcgtattggg cgctcttccg cttcctcgct cactgactcg     9360

ctgcgctcgg tcgttcggct gcggcgagcg gtatcagctc actcaaaggc ggtaatacgg     9420

ttatccacag aatcagggga taacgcagga aagaacatgt gagcaaaagg ccagcaaaag     9480

gccaggaacc gtaaaaaggc cgcgttgctg gcgtttttcc ataggctccg cccccctgac     9540

gagcatcaca aaaatcgacg ctcaagtcag aggtggcgaa acccgacagg actataaaga     9600

taccaggcgt ttccccctgg aagctccctc gtgcgctctc ctgttccgac cctgccgctt     9660

accggatacc tgtccgcctt tctcccttcg ggaagcgtgg cgctttctca tagctcacgc     9720

tgtaggtatc tcagttcggt gtaggtcgtt cgctccaagc tgggctgtgt gcacgaaccc     9780

cccgttcagc ccgaccgctg cgccttatcc ggtaactatc gtcttgagtc caacccggta     9840

agacacgact tatcgccact ggcagcagcc actggtaaca ggattagcag agcgaggtat     9900

gtaggcggtg ctacagagtt cttgaagtgg tggcctaact acggctacac tagaagaaca     9960

gtatttggta tctgcgctct gctgaagcca gttaccttcg gaaaaagagt tggtagctct    10020

tgatccggca aacaaaccac cgctggtagc ggtggttttt ttgtttgcaa gcagcagatt    10080

acgcgcagaa aaaaaggatc tcaagaagat cctttgatct tttctacggg gtctgacgct    10140

cagtggaacg aaaactcacg ttaagggatt ttggtcatga gattatcaaa aaggatcttc    10200

acctagatcc ttttaaatta aaaatgaagt tttaaatcaa tctaaagtat atatgagtaa    10260

acttggtctg acagttacca atgcttaatc agtgaggcac ctatctcagc gatctgtcta    10320

tttcgttcat ccatagttgc ctgactcccc gtcgtgtaga taactacgat acgggagggc    10380

ttaccatctg gccccagtgc tgcaatgata ccgcgagacc cacgctcacc ggctccagat    10440

ttatcagcaa taaaccagcc agccggaagg gccgagcgca gaagtggtcc tgcaacttta    10500

tccgcctcca tccagtctat taattgttgc cgggaagcta gagtaagtag ttcgccagtt    10560

aatagtttgc gcaacgttgt tgccattgct acaggcatcg tggtgtcacg ctcgtcgttt    10620

ggtatggctt cattcagctc cggttcccaa cgatcaaggc gagttacatg atcccccatg    10680

ttgtgcaaaa aagcggttag ctccttcggt cctccgatcg ttgtcagaag taagttggcc    10740

gcagtgttat cactcatggt tatggcagca ctgcataatt ctcttactgt catgccatcc    10800

gtaagatgct tttctgtgac tggtgagtac tcaaccaagt cattctgaga atagtgtatg    10860

cggcgaccga gttgctcttg cccggcgtca atacgggata ataccgcgcc acatagcaga    10920

actttaaaag tgctcatcat tggaaaacgt tcttcggggc gaaaactctc aaggatctta    10980

ccgctgttga gatccagttc gatgtaaccc actcgtgcac ccaactgatc ttcagcatct    11040

tttactttca ccagcgtttc tgggtgagca aaaacaggaa ggcaaaatgc cgcaaaaaag    11100

ggaataaggg cgacacggaa atgttgaata ctcatactct tcctttttca atattattga    11160

agcatttatc agggttattg tctcatgagc ggatacatat ttgaatgtat ttagaaaaat    11220

aaacaaatag gggttccgcg cacatttccc cgaaaagtgc cacctgac                 11268


<210>  688
<211>  11379
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Synthetic nucleotide

<400>  688
gtcgacggat cgggagatct cccgatcccc tatggtgcac tctcagtaca atctgctctg       60

atgccgcata gttaagccag tatctgctcc ctgcttgtgt gttggaggtc gctgagtagt      120

gcgcgagcaa aatttaagct acaacaaggc aaggcttgac cgacaattgc atgaagaatc      180

tgcttagggt taggcgtttt gcgctgcttc gcgatgtacg ggccagatat acgcgttgac      240

attgattatt gactagttat taatagtaat caattacggg gtcattagtt catagcccat      300

atatggagtt ccgcgttaca taacttacgg taaatggccc gcctggctga ccgcccaacg      360

acccccgccc attgacgtca ataatgacgt atgttcccat agtaacgcca atagggactt      420

tccattgacg tcaatgggtg gagtatttac ggtaaactgc ccacttggca gtacatcaag      480

tgtatcatat gccaagtacg ccccctattg acgtcaatga cggtaaatgg cccgcctggc      540

attatgccca gtacatgacc ttatgggact ttcctacttg gcagtacatc tacgtattag      600

tcatcgctat taccatggtg atgcggtttt ggcagtacat caatgggcgt ggatagcggt      660

ttgactcacg gggatttcca agtctccacc ccattgacgt caatgggagt ttgttttggc      720

accaaaatca acgggacttt ccaaaatgtc gtaacaactc cgccccattg acgcaaatgg      780

gcggtaggcg tgtacggtgg gaggtctata taagcagcgc gttttgcctg tactgggtct      840

ctctggttag accagatctg agcctgggag ctctctggct aactagggaa cccactgctt      900

aagcctcaat aaagcttgcc ttgagtgctt caagtagtgt gtgcccgtct gttgtgtgac      960

tctggtaact agagatccct cagacccttt tagtcagtgt ggaaaatctc tagcagtggc     1020

gcccgaacag ggacttgaaa gcgaaaggga aaccagagga gctctctcga cgcaggactc     1080

ggcttgctga agcgcgcacg gcaagaggcg aggggcggcg actggtgagt acgccaaaaa     1140

ttttgactag cggaggctag aaggagagag atgggtgcga gagcgtcagt attaagcggg     1200

ggagaattag atcgcgatgg gaaaaaattc ggttaaggcc agggggaaag aaaaaatata     1260

aattaaaaca tatagtatgg gcaagcaggg agctagaacg attcgcagtt aatcctggcc     1320

tgttagaaac atcagaaggc tgtagacaaa tactgggaca gctacaacca tcccttcaga     1380

caggatcaga agaacttaga tcattatata atacagtagc aaccctctat tgtgtgcatc     1440

aaaggataga gataaaagac accaaggaag ctttagacaa gatagaggaa gagcaaaaca     1500

aaagtaagac caccgcacag caagcggccg ctgatcttca gacctggagg aggagatatg     1560

agggacaatt ggagaagtga attatataaa tataaagtag taaaaattga accattagga     1620

gtagcaccca ccaaggcaaa gagaagagtg gtgcagagag aaaaaagagc agtgggaata     1680

ggagctttgt tccttgggtt cttgggagca gcaggaagca ctatgggcgc agcgtcaatg     1740

acgctgacgg tacaggccag acaattattg tctggtatag tgcagcagca gaacaatttg     1800

ctgagggcta ttgaggcgca acagcatctg ttgcaactca cagtctgggg catcaagcag     1860

ctccaggcaa gaatcctggc tgtggaaaga tacctaaagg atcaacagct cctggggatt     1920

tggggttgct ctggaaaact catttgcacc actgctgtgc cttggaatgc tagttggagt     1980

aataaatctc tggaacagat ttggaatcac acgacctgga tggagtggga cagagaaatt     2040

aacaattaca caagcttaat acactcctta attgaagaat cgcaaaacca gcaagaaaag     2100

aatgaacaag aattattgga attagataaa tgggcaagtt tgtggaattg gtttaacata     2160

acaaattggc tgtggtatat aaaattattc ataatgatag taggaggctt ggtaggttta     2220

agaatagttt ttgctgtact ttctatagtg aatagagtta ggcagggata ttcaccatta     2280

tcgtttcaga cccacctccc aaccccgagg ggacccgaca ggcccgaagg aatagaagaa     2340

gaaggtggag agagagacag agacagatcc attcgattag tgaacggatc ggcactgcgt     2400

gcgccaattc tgcagacaaa tggcagtatt catccacaat tttaaaagaa aaggggggat     2460

tggggggtac agtgcagggg aaagaatagt agacataata gcaacagaca tacaaactaa     2520

agaattacaa aaacaaatta caaaaattca aaattttcgg gtttattaca gggacagcag     2580

agatccagtt tggttaatta gctagctagg tcttgaaagg agtgggaatt ggctccggtg     2640

cccgtcagtg ggcagagcgc acatcgccca cagtccccga gaagttgggg ggaggggtcg     2700

gcaattgatc cggtgcctag agaaggtggc gcggggtaaa ctgggaaagt gatgtcgtgt     2760

actggctccg cctttttccc gagggtgggg gagaaccgta tataagtgca gtagtcgccg     2820

tgaacgttct ttttcgcaac gggtttgccg ccagaacaca ggaccggttc tagagcgctt     2880

taattaagcc accatggccc tgcctgtgac cgcgctgctg ctgcctctgg ccctgctgct     2940

gcatgccgcc aggccacaga tccagctggt gcagagcgga cctgaactga agaagcctgg     3000

ggaaaccgtg aagatcagct gcaaggcctc cggctacacc ttcacaaact acggcatgaa     3060

ctgggtgaag caggcccctg gaaagggcct gaaatggatg ggctggatca acaccaagac     3120

cggcgagcct acctacgccg aagagttcaa gggcagattc gccttcagcc tggagacctc     3180

agccagcacc gcctacctgc agatcaacaa cctgaagaag gaagataccg ccacctactt     3240

ctgcggccgg ggcggttatg gcagcagcta ctggtacttc gacgtgtggg gcgccggcac     3300

aacagtgaca gtatccagcg cctccacaaa aggacctagc ggcggcggcg gcagcggtgg     3360

tggcggaagt ggcggcggcg gcagcggcgg cggtggaagc gacatcgtga tgacccagag     3420

ccataagttc atgagcacaa gcgtgggcga tcgggtgagc atcacctgca aggcctctca     3480

ggacgtgagc atcgccgtgg cctggtatca gcagaaacct gggcagtccc ctaaggtgtt     3540

gatctattct gcttcctacc gatacacagg agtgcctgac cggttcaccg gctctggcag     3600

cggcaccgat ttcaccttta caatcagcag agtgcaggct gaggacctgg ccgtgtacta     3660

ctgtcagcag cactacatca cccctctgac ctttggcgcc ggaactaaac tggaactgaa     3720

gcggaccgtg gccgatatgg ctgatatacc cggccacgtg ttcactagag gcatgatcat     3780

tgccgtgttg atcctggtgg ccgtggtttg cctggtgacc gtgtgcgtga tctacagagt     3840

ggacctggtc ctgttctaca gacacctgac cagacgcgac gagaccctga cagacggcaa     3900

aacatacgac gccttcgtgt cctacctgaa agagtgcaga cctgagaatg gcgaggaaca     3960

cacctttgcc gtcgagatcc tgcccagagt gctggaaaag cacttcggct ataagctgtg     4020

tatcttcgag cgggacgtgg tgccaggcgg cgccgtggtg gacgagatcc acagcctgat     4080

tgagaaaagc cggcggctga tcatcgtgct gagcaagtcg tacatgagca atgaagtgcg     4140

gtacgagctg gaaagcggcc tgcacgaggc cctggtcgag agaaagatta agatcatcct     4200

gatcgagttt acacccgtga cagactttac cttcctgccc cagagcctga aactgctgaa     4260

gagccataga gtgctgaagt ggaaggctga taagtctctg agctacaact ctcgcttctg     4320

gaagaacctg ctctacctga tgcctgccaa gacagttaag cccggcagag acgagcccga     4380

ggtgctgcct gtgctttccg agagcggatc tggcgaaggc agaggttccc tgcttacatg     4440

tggcgacgtg gaggaaaatc ctggccctat ggccctgcct gttaccgctc tgctgctgcc     4500

tctggccctg ctgctgcacg ccgctagacc tcaggtgcaa ctgcaacaga gcggccctga     4560

actggtcaga cccggaacct ccgtgcggat cagttgcaag gccagcggct acaccttcac     4620

catctactgg ctgggatggg ttaagcagag acctggccac ggcttggagt ggatcggcaa     4680

catctttccc ggctccgcct atatcaacta caacgagaaa ttcaaaggga aggcgaccct     4740

gacagccgac accagcagtt ccaccgccta catgcagctg tccagcctga catctgagga     4800

cagcgcagtg tatttttgcg ccagagaagg cagcaacagc ggatactggg gacagggcac     4860

cacactcacc gtgagcagcg gaggcggcgg cagcggcggc ggcggaagcg gcggcggcgg     4920

gagcggcggc ggcggatctg acatcgtgat gacccaaagc cctagcagcc tgagtgtgag     4980

cgccggcgag aaggtgacca tgacctgtaa aagcagccag tcgctgctga acagcggcaa     5040

tcagcagaac tacctggcat ggtatcagca aaagcccggc cagcctccaa agctgcttat     5100

ctacggtgcc agcacccggg agagcggcgt tcctgatcgg ttcactggaa gtggcagcgg     5160

aaccgacttc acactgacga tcaatagcgt gcaggccgag gacctggccg tgtactactg     5220

ccaaagcgac cacatctacc cctacacctt cggggggggc accaagctcg aaatcaagaa     5280

cacaacacag tctgtgcagc tgaaagagaa gagaggcgtg gttctgctgt acatccttct     5340

tggaaccatc ggcaccctgg tggccgtgtt agccgcctct gctctgctgt accggcactg     5400

gatcgagatc gtgctgctgt atagaacata ccagtctaag gaccagaccc tgggcgacaa     5460

gaaagatttc gatgccttcg tgtcctacgc taagtggagc agcttccctt ctgaagccac     5520

ctctagcctg tctgaagagc acctggccct gagcctgttt ccagatgtgc tggagaacaa     5580

gtacggatac agcctgtgcc tgctggaaag agacgtggcc cctggaggcg tgtacgccga     5640

agacatcgtc agcatcatca agcggagcag aagaggcatc ttcatcctga gcccaaacta     5700

cgtgaacggc cccagcatct tcgagctgca ggccgccgtg aacctggctc ttgatgacca     5760

aacactgaag ctgatcctga tcaagttctg ctactttcag gagcctgaat ccctgccgca     5820

cctggtgaag aaggccctga gagttctgcc caccgtgacc tggcgcggac tgaaatctgt     5880

tcctcctaat agcaggttct gggccaagat gagataccac atgccagtga agaacagcca     5940

ggggttcacc tggaaccagc tgagaatcac aagcagaatc ttccagtgga agggcctgtc     6000

tcgaacagag accaccggca gaagcagcca acctaaggaa tggtgagaat tcgatatcaa     6060

gcttatcggt aatcaacctc tggattacaa aatttgtgaa agattgactg gtattcttaa     6120

ctatgttgct ccttttacgc tatgtggata cgctgcttta atgcctttgt atcatgctat     6180

tgcttcccgt atggctttca ttttctcctc cttgtataaa tcctggttgc tgtctcttta     6240

tgaggagttg tggcccgttg tcaggcaacg tggcgtggtg tgcactgtgt ttgctgacgc     6300

aacccccact ggttggggca ttgccaccac ctgtcagctc ctttccggga ctttcgcttt     6360

ccccctccct attgccacgg cggaactcat cgccgcctgc cttgcccgct gctggacagg     6420

ggctcggctg ttgggcactg acaattccgt ggtgttgtcg gggaaatcat cgtcctttcc     6480

ttggctgctc gcctgtgttg ccacctggat tctgcgcggg acgtccttct gctacgtccc     6540

ttcggccctc aatccagcgg accttccttc ccgcggcctg ctgccggctc tgcggcctct     6600

tccgcgtctt cgccttcgcc ctcagacgag tcggatctcc ctttgggccg cctccccgca     6660

tcgataccgt cgacctcgag acctagaaaa acatggagca atcacaagta gcaatacagc     6720

agctaccaat gctgattgtg cctggctaga agcacaagag gaggaggagg tgggttttcc     6780

agtcacacct caggtacctt taagaccaat gacttacaag gcagctgtag atcttagcca     6840

ctttttaaaa gaaaaggggg gactggaagg gctaattcac tcccaacgaa gacaagatat     6900

ccttgatctg tggatctacc acacacaagg ctacttccct gattggcaga actacacacc     6960

agggccaggg atcagatatc cactgacctt tggatggtgc tacaagctag taccagttga     7020

gcaagagaag gtagaagaag ccaatgaagg agagaacacc cgcttgttac accctgtgag     7080

cctgcatggg atggatgacc cggagagaga agtattagag tggaggtttg acagccgcct     7140

agcatttcat cacatggccc gagagctgca tccggactgt actgggtctc tctggttaga     7200

ccagatctga gcctgggagc tctctggcta actagggaac ccactgctta agcctcaata     7260

aagcttgcct tgagtgcttc aagtagtgtg tgcccgtctg ttgtgtgact ctggtaacta     7320

gagatccctc agaccctttt agtcagtgtg gaaaatctct agcagggccc gtttaaaccc     7380

gctgatcagc ctcgactgtg ccttctagtt gccagccatc tgttgtttgc ccctcccccg     7440

tgccttcctt gaccctggaa ggtgccactc ccactgtcct ttcctaataa aatgaggaaa     7500

ttgcatcgca ttgtctgagt aggtgtcatt ctattctggg gggtggggtg gggcaggaca     7560

gcaaggggga ggattgggaa gacaatagca ggcatgctgg ggatgcggtg ggctctatgg     7620

cttctgaggc ggaaagaacc agctggggct ctagggggta tccccacgcg ccctgtagcg     7680

gcgcattaag cgcggcgggt gtggtggtta cgcgcagcgt gaccgctaca cttgccagcg     7740

ccctagcgcc cgctcctttc gctttcttcc cttcctttct cgccacgttc gccggctttc     7800

cccgtcaagc tctaaatcgg gggctccctt tagggttccg atttagtgct ttacggcacc     7860

tcgaccccaa aaaacttgat tagggtgatg gttcacgtag tgggccatcg ccctgataga     7920

cggtttttcg ccctttgacg ttggagtcca cgttctttaa tagtggactc ttgttccaaa     7980

ctggaacaac actcaaccct atctcggtct attcttttga tttataaggg attttgccga     8040

tttcggccta ttggttaaaa aatgagctga tttaacaaaa atttaacgcg aattaattct     8100

gtggaatgtg tgtcagttag ggtgtggaaa gtccccaggc tccccagcag gcagaagtat     8160

gcaaagcatg catctcaatt agtcagcaac caggtgtgga aagtccccag gctccccagc     8220

aggcagaagt atgcaaagca tgcatctcaa ttagtcagca accatagtcc cgcccctaac     8280

tccgcccatc ccgcccctaa ctccgcccag ttccgcccat tctccgcccc atggctgact     8340

aatttttttt atttatgcag aggccgaggc cgcctctgcc tctgagctat tccagaagta     8400

gtgaggaggc ttttttggag gcctaggctt ttgcaaaaag ctcccgggag cttgtatatc     8460

cattttcgga tctgatcagc acgtgttgac aattaatcat cggcatagta tatcggcata     8520

gtataatacg acaaggtgag gaactaaacc atggccaagt tgaccagtgc cgttccggtg     8580

ctcaccgcgc gcgacgtcgc cggagcggtc gagttctgga ccgaccggct cgggttctcc     8640

cgggacttcg tggaggacga cttcgccggt gtggtccggg acgacgtgac cctgttcatc     8700

agcgcggtcc aggaccaggt ggtgccggac aacaccctgg cctgggtgtg ggtgcgcggc     8760

ctggacgagc tgtacgccga gtggtcggag gtcgtgtcca cgaacttccg ggacgcctcc     8820

gggccggcca tgaccgagat cggcgagcag ccgtgggggc gggagttcgc cctgcgcgac     8880

ccggccggca actgcgtgca cttcgtggcc gaggagcagg actgacacgt gctacgagat     8940

ttcgattcca ccgccgcctt ctatgaaagg ttgggcttcg gaatcgtttt ccgggacgcc     9000

ggctggatga tcctccagcg cggggatctc atgctggagt tcttcgccca ccccaacttg     9060

tttattgcag cttataatgg ttacaaataa agcaatagca tcacaaattt cacaaataaa     9120

gcattttttt cactgcattc tagttgtggt ttgtccaaac tcatcaatgt atcttatcat     9180

gtctgtatac cgtcgacctc tagctagagc ttggcgtaat catggtcata gctgtttcct     9240

gtgtgaaatt gttatccgct cacaattcca cacaacatac gagccggaag cataaagtgt     9300

aaagcctggg gtgcctaatg agtgagctaa ctcacattaa ttgcgttgcg ctcactgccc     9360

gctttccagt cgggaaacct gtcgtgccag ctgcattaat gaatcggcca acgcgcgggg     9420

agaggcggtt tgcgtattgg gcgctcttcc gcttcctcgc tcactgactc gctgcgctcg     9480

gtcgttcggc tgcggcgagc ggtatcagct cactcaaagg cggtaatacg gttatccaca     9540

gaatcagggg ataacgcagg aaagaacatg tgagcaaaag gccagcaaaa ggccaggaac     9600

cgtaaaaagg ccgcgttgct ggcgtttttc cataggctcc gcccccctga cgagcatcac     9660

aaaaatcgac gctcaagtca gaggtggcga aacccgacag gactataaag ataccaggcg     9720

tttccccctg gaagctccct cgtgcgctct cctgttccga ccctgccgct taccggatac     9780

ctgtccgcct ttctcccttc gggaagcgtg gcgctttctc atagctcacg ctgtaggtat     9840

ctcagttcgg tgtaggtcgt tcgctccaag ctgggctgtg tgcacgaacc ccccgttcag     9900

cccgaccgct gcgccttatc cggtaactat cgtcttgagt ccaacccggt aagacacgac     9960

ttatcgccac tggcagcagc cactggtaac aggattagca gagcgaggta tgtaggcggt    10020

gctacagagt tcttgaagtg gtggcctaac tacggctaca ctagaagaac agtatttggt    10080

atctgcgctc tgctgaagcc agttaccttc ggaaaaagag ttggtagctc ttgatccggc    10140

aaacaaacca ccgctggtag cggtggtttt tttgtttgca agcagcagat tacgcgcaga    10200

aaaaaaggat ctcaagaaga tcctttgatc ttttctacgg ggtctgacgc tcagtggaac    10260

gaaaactcac gttaagggat tttggtcatg agattatcaa aaaggatctt cacctagatc    10320

cttttaaatt aaaaatgaag ttttaaatca atctaaagta tatatgagta aacttggtct    10380

gacagttacc aatgcttaat cagtgaggca cctatctcag cgatctgtct atttcgttca    10440

tccatagttg cctgactccc cgtcgtgtag ataactacga tacgggaggg cttaccatct    10500

ggccccagtg ctgcaatgat accgcgagac ccacgctcac cggctccaga tttatcagca    10560

ataaaccagc cagccggaag ggccgagcgc agaagtggtc ctgcaacttt atccgcctcc    10620

atccagtcta ttaattgttg ccgggaagct agagtaagta gttcgccagt taatagtttg    10680

cgcaacgttg ttgccattgc tacaggcatc gtggtgtcac gctcgtcgtt tggtatggct    10740

tcattcagct ccggttccca acgatcaagg cgagttacat gatcccccat gttgtgcaaa    10800

aaagcggtta gctccttcgg tcctccgatc gttgtcagaa gtaagttggc cgcagtgtta    10860

tcactcatgg ttatggcagc actgcataat tctcttactg tcatgccatc cgtaagatgc    10920

ttttctgtga ctggtgagta ctcaaccaag tcattctgag aatagtgtat gcggcgaccg    10980

agttgctctt gcccggcgtc aatacgggat aataccgcgc cacatagcag aactttaaaa    11040

gtgctcatca ttggaaaacg ttcttcgggg cgaaaactct caaggatctt accgctgttg    11100

agatccagtt cgatgtaacc cactcgtgca cccaactgat cttcagcatc ttttactttc    11160

accagcgttt ctgggtgagc aaaaacagga aggcaaaatg ccgcaaaaaa gggaataagg    11220

gcgacacgga aatgttgaat actcatactc ttcctttttc aatattattg aagcatttat    11280

cagggttatt gtctcatgag cggatacata tttgaatgta tttagaaaaa taaacaaata    11340

ggggttccgc gcacatttcc ccgaaaagtg ccacctgac                           11379


<210>  689
<211>  232
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic amino acid

<400>  689

Met Asp Trp Thr Trp Ile Leu Phe Leu Val Ala Ala Ala Thr Arg Val 
1               5                   10                  15      


His Ser Gln Val Thr Asp Ile Asn Ser Lys Gly Leu Glu Leu Arg Lys 
            20                  25                  30          


Thr Val Thr Thr Val Glu Thr Gln Asn Leu Glu Gly Leu His His Asp 
        35                  40                  45              


Gly Gln Phe Cys His Lys Pro Cys Pro Pro Gly Glu Arg Lys Ala Arg 
    50                  55                  60                  


Asp Cys Thr Val Asn Gly Asp Glu Pro Asp Cys Val Pro Cys Gln Glu 
65                  70                  75                  80  


Gly Lys Glu Tyr Thr Asp Lys Ala His Phe Ser Ser Lys Cys Arg Arg 
                85                  90                  95      


Cys Arg Leu Cys Asp Glu Gly His Gly Leu Glu Val Glu Ile Asn Cys 
            100                 105                 110         


Thr Arg Thr Gln Asn Thr Lys Cys Arg Cys Lys Pro Asn Phe Phe Cys 
        115                 120                 125             


Asn Ser Thr Val Cys Glu His Cys Asp Pro Cys Thr Lys Cys Glu His 
    130                 135                 140                 


Gly Ile Ile Lys Glu Cys Thr Leu Thr Ser Asn Thr Lys Cys Lys Glu 
145                 150                 155                 160 


Glu Gly Ser Arg Ser Asn Leu Gly Trp Leu Cys Leu Leu Leu Leu Pro 
                165                 170                 175     


Ile Pro Leu Ile Val Trp Val Lys Arg Lys Glu Val Gln Lys Lys Arg 
            180                 185                 190         


Gly Arg Lys Lys Leu Leu Tyr Ile Phe Lys Gln Pro Phe Met Arg Pro 
        195                 200                 205             


Val Gln Thr Thr Gln Glu Glu Asp Gly Cys Ser Cys Arg Phe Pro Glu 
    210                 215                 220                 


Glu Glu Glu Gly Gly Cys Glu Leu 
225                 230         


<210>  690
<211>  231
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic amino acid

<400>  690

Met Asp Trp Thr Trp Ile Leu Phe Leu Val Ala Ala Ala Thr Arg Val 
1               5                   10                  15      


His Ser Phe Leu Asp Ser Pro Asp Arg Pro Trp Asn Pro Pro Thr Phe 
            20                  25                  30          


Ser Pro Ala Leu Leu Val Val Thr Glu Gly Asp Asn Ala Thr Phe Thr 
        35                  40                  45              


Cys Ser Phe Ser Asn Thr Ser Glu Ser Phe Val Leu Asn Trp Tyr Arg 
    50                  55                  60                  


Met Ser Pro Ser Asn Gln Thr Asp Lys Leu Ala Ala Phe Pro Glu Asp 
65                  70                  75                  80  


Arg Ser Gln Pro Gly Gln Asp Cys Arg Phe Arg Val Thr Gln Leu Pro 
                85                  90                  95      


Asn Gly Arg Asp Phe His Met Ser Val Val Arg Ala Arg Arg Asn Asp 
            100                 105                 110         


Ser Gly Thr Tyr Leu Cys Gly Ala Ile Ser Leu Ala Pro Lys Ala Gln 
        115                 120                 125             


Ile Lys Glu Ser Leu Arg Ala Glu Leu Arg Val Thr Glu Arg Arg Ala 
    130                 135                 140                 


Glu Val Pro Thr Ala His Pro Ala Pro Ala Arg Glu Pro Gly His Ser 
145                 150                 155                 160 


Pro Gln Ile Ile Ser Phe Phe Leu Ala Leu Thr Ser Thr Ala Leu Leu 
                165                 170                 175     


Phe Leu Leu Phe Phe Leu Thr Leu Arg Phe Ser Val Val Lys Arg Gly 
            180                 185                 190         


Arg Lys Lys Leu Leu Tyr Ile Phe Lys Gln Pro Phe Met Arg Pro Val 
        195                 200                 205             


Gln Thr Thr Gln Glu Glu Asp Gly Cys Ser Cys Arg Phe Pro Glu Glu 
    210                 215                 220                 


Glu Glu Gly Gly Cys Glu Leu 
225                 230     


<210>  691
<211>  243
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic amino acid

<400>  691

Met Asp Trp Thr Trp Ile Leu Phe Leu Val Ala Ala Ala Thr Arg Val 
1               5                   10                  15      


His Ser Thr Ile Pro Pro His Val Gln Lys Ser Val Asn Asn Asp Met 
            20                  25                  30          


Ile Val Thr Asp Asn Asn Gly Ala Val Lys Phe Pro Gln Leu Cys Lys 
        35                  40                  45              


Phe Cys Asp Val Arg Phe Ser Thr Cys Asp Asn Gln Lys Ser Cys Met 
    50                  55                  60                  


Ser Asn Cys Ser Ile Thr Ser Ile Cys Glu Lys Pro Gln Glu Val Cys 
65                  70                  75                  80  


Val Ala Val Trp Arg Lys Asn Asp Glu Asn Ile Thr Leu Glu Thr Val 
                85                  90                  95      


Cys His Asp Pro Lys Leu Pro Tyr His Asp Phe Ile Leu Glu Asp Ala 
            100                 105                 110         


Ala Ser Pro Lys Cys Ile Met Lys Glu Lys Lys Lys Pro Gly Glu Thr 
        115                 120                 125             


Phe Phe Met Cys Ser Cys Ser Ser Asp Glu Cys Asn Asp Asn Ile Ile 
    130                 135                 140                 


Phe Ser Glu Glu Tyr Asn Thr Ser Asn Pro Asp Leu Leu Leu Val Ile 
145                 150                 155                 160 


Phe Gln Pro Ala Pro Ala Arg Glu Pro Gly His Ser Pro Gln Ile Ile 
                165                 170                 175     


Ser Phe Phe Leu Ala Leu Thr Ser Thr Ala Leu Leu Phe Leu Leu Phe 
            180                 185                 190         


Phe Leu Thr Leu Arg Phe Ser Val Val Lys Arg Gly Arg Lys Lys Leu 
        195                 200                 205             


Leu Tyr Ile Phe Lys Gln Pro Phe Met Arg Pro Val Gln Thr Thr Gln 
    210                 215                 220                 


Glu Glu Asp Gly Cys Ser Cys Arg Phe Pro Glu Glu Glu Glu Gly Gly 
225                 230                 235                 240 


Cys Glu Leu 
            


<210>  692
<211>  230
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic amino acid

<400>  692

Met Asp Trp Thr Trp Ile Leu Phe Leu Val Ala Ala Ala Thr Arg Val 
1               5                   10                  15      


His Ser Phe Leu Asp Ser Pro Asp Arg Pro Trp Asn Pro Pro Thr Phe 
            20                  25                  30          


Ser Pro Ala Leu Leu Val Val Thr Glu Gly Asp Asn Ala Thr Phe Thr 
        35                  40                  45              


Cys Ser Phe Ser Asn Thr Ser Glu Ser Phe Val Leu Asn Trp Tyr Arg 
    50                  55                  60                  


Met Ser Pro Ser Asn Gln Thr Asp Lys Leu Ala Ala Phe Pro Glu Asp 
65                  70                  75                  80  


Arg Ser Gln Pro Gly Gln Asp Cys Arg Phe Arg Val Thr Gln Leu Pro 
                85                  90                  95      


Asn Gly Arg Asp Phe His Met Ser Val Val Arg Ala Arg Arg Asn Asp 
            100                 105                 110         


Ser Gly Thr Tyr Leu Cys Gly Ala Ile Ser Leu Ala Pro Lys Ala Gln 
        115                 120                 125             


Ile Lys Glu Ser Leu Arg Ala Glu Leu Arg Val Thr Glu Arg Arg Ala 
    130                 135                 140                 


Glu Val Pro Thr Ala His Cys Pro Ser Pro Leu Phe Pro Gly Pro Ser 
145                 150                 155                 160 


Lys Pro Phe Trp Val Leu Val Val Val Gly Gly Val Leu Ala Cys Tyr 
                165                 170                 175     


Ser Leu Leu Val Thr Val Ala Phe Ile Ile Phe Trp Val Arg Ser Lys 
            180                 185                 190         


Arg Ser Arg Leu Leu His Ser Asp Tyr Met Asn Met Thr Pro Arg Arg 
        195                 200                 205             


Pro Gly Pro Thr Arg Lys His Tyr Gln Pro Tyr Ala Pro Pro Arg Asp 
    210                 215                 220                 


Phe Ala Ala Tyr Arg Ser 
225                 230 


<210>  693
<211>  172
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic amino acid

<400>  693

Gln Val Thr Asp Ile Asn Ser Lys Gly Leu Glu Leu Arg Lys Thr Val 
1               5                   10                  15      


Thr Thr Val Glu Thr Gln Asn Leu Glu Gly Leu His His Asp Gly Gln 
            20                  25                  30          


Phe Cys His Lys Pro Cys Pro Pro Gly Glu Arg Lys Ala Arg Asp Cys 
        35                  40                  45              


Thr Val Asn Gly Asp Glu Pro Asp Cys Val Pro Cys Gln Glu Gly Lys 
    50                  55                  60                  


Glu Tyr Thr Asp Lys Ala His Phe Ser Ser Lys Cys Arg Arg Cys Arg 
65                  70                  75                  80  


Leu Cys Asp Glu Gly His Gly Leu Glu Val Glu Ile Asn Cys Thr Arg 
                85                  90                  95      


Thr Gln Asn Thr Lys Cys Arg Cys Lys Pro Asn Phe Phe Cys Asn Ser 
            100                 105                 110         


Thr Val Cys Glu His Cys Asp Pro Cys Thr Lys Cys Glu His Gly Ile 
        115                 120                 125             


Ile Lys Glu Cys Thr Leu Thr Ser Asn Thr Lys Cys Lys Glu Glu Gly 
    130                 135                 140                 


Ser Arg Ser Asn Leu Gly Trp Leu Cys Leu Leu Leu Leu Pro Ile Pro 
145                 150                 155                 160 


Leu Ile Val Trp Val Lys Arg Lys Glu Val Gln Lys 
                165                 170         


<210>  694
<211>  145
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic amino acid

<400>  694

Ser Thr Ile Pro Pro His Val Gln Lys Ser Val Asn Asn Asp Met Ile 
1               5                   10                  15      


Val Thr Asp Asn Asn Gly Ala Val Lys Phe Pro Gln Leu Cys Lys Phe 
            20                  25                  30          


Cys Asp Val Arg Phe Ser Thr Cys Asp Asn Gln Lys Ser Cys Met Ser 
        35                  40                  45              


Asn Cys Ser Ile Thr Ser Ile Cys Glu Lys Pro Gln Glu Val Cys Val 
    50                  55                  60                  


Ala Val Trp Arg Lys Asn Asp Glu Asn Ile Thr Leu Glu Thr Val Cys 
65                  70                  75                  80  


His Asp Pro Lys Leu Pro Tyr His Asp Phe Ile Leu Glu Asp Ala Ala 
                85                  90                  95      


Ser Pro Lys Cys Ile Met Lys Glu Lys Lys Lys Pro Gly Glu Thr Phe 
            100                 105                 110         


Phe Met Cys Ser Cys Ser Ser Asp Glu Cys Asn Asp Asn Ile Ile Phe 
        115                 120                 125             


Ser Glu Glu Tyr Asn Thr Ser Asn Pro Asp Leu Leu Leu Val Ile Phe 
    130                 135                 140                 


Gln 
145 


<210>  695
<211>  696
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Synthetic nucleotide

<400>  695
atggactgga cctggattct gttcctggtg gccgccgcta caagagtgca cagccaggtg       60

accgacatca actccaaggg cctggaactg agaaagaccg tgacaaccgt tgagacacaa      120

aatctggaag gcctgcacca cgacggccag ttttgccaca agccttgtcc tccaggcgag      180

cggaaggcca gagattgcac cgtgaacggc gatgagcctg actgcgtgcc atgtcaggag      240

ggcaaggaat acaccgataa ggcccacttc agcagcaagt gcaggcggtg ccggctgtgc      300

gacgagggcc acggactgga agtggaaatc aactgcacca gaacacagaa cacaaagtgc      360

agatgcaagc ccaacttctt ctgcaacagc accgtgtgcg agcattgtga cccctgcaca      420

aaatgtgaac acggcatcat caaggagtgc accctgacca gcaacaccaa gtgtaaagag      480

gaaggaagca gaagcaatct gggctggctg tgtctgctcc tgctgcctat tcctctgatc      540

gtgtgggtca agagaaaaga ggtgcagaag aagcggggca gaaagaaact gctgtacatc      600

ttcaagcagc cttttatgcg gcctgtgcag accactcagg aggaggacgg ctgcagctgc      660

agattccccg aggaagagga aggcggatgt gagctg                                696


<210>  696
<211>  693
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Synthetic nucleotide

<400>  696
atggactgga cctggattct gttcctggtc gccgccgcca caagagtgca ttcttttctg       60

gacagccctg atagaccttg gaaccctcca accttttccc ccgccctgct ggtggtgacc      120

gagggcgaca acgccacctt cacctgtagc ttttccaata ccagcgagag cttcgtgctg      180

aactggtaca gaatgtctcc tagcaaccag accgacaagc tggccgcttt tcctgaggac      240

agatcccagc ccggccagga ctgcagattc agagtgaccc agctgcctaa cggcagagat      300

ttccacatga gcgtggtgag agccagaaga aacgacagcg gcacctacct gtgcggagcc      360

atcagcctgg ctcctaaggc ccagattaag gaatctctga gagccgagct gagggtgaca      420

gagagaagag ctgaagtgcc tacagcccac cccgccccag ctcgcgagcc tggacacagc      480

cctcagatca tctctttctt cctggccctg accagcaccg ccctgctctt cctgctcttc      540

ttcctgacac tgcggttcag cgttgtgaaa cggggccgaa aaaagctgct gtacatcttc      600

aagcagcctt tcatgcggcc cgtgcaaaca acacaggagg aagatggctg cagctgccgg      660

ttccccgagg aagaggaagg cggctgtgaa ctg                                   693


<210>  697
<211>  729
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Synthetic nucleotide

<400>  697
atggactgga cctggattct gtttctggtc gccgccgcta caagagttca cagcaccatc       60

cctcctcatg tgcaaaaatc cgtgaacaac gacatgatcg tgaccgacaa taacggcgcc      120

gtcaaattcc cccagctgtg caagttctgc gacgtgcggt tttctacatg tgataaccag      180

aagtcctgca tgagcaactg cagcatcaca agcatctgcg agaaacctca ggaggtgtgc      240

gtggccgtgt ggcggaagaa cgacgagaac atcaccctgg aaaccgtgtg tcacgacccc      300

aagctgcctt accacgactt catcctggaa gatgccgcct ctccaaagtg catcatgaag      360

gaaaagaaaa agcccggcga gaccttcttc atgtgctctt gttctagcga tgagtgcaat      420

gataacatca ttttcagcga ggaatacaac accagcaatc ccgacctgct gctcgtgatc      480

tttcagcccg cccctgctag agagcctgga cactcccctc agatcatcag cttcttcctg      540

gccctgacaa gcacagccct gctgtttctg ctgttcttcc tgaccctgag attcagcgtg      600

gtgaagcggg gaagaaagaa gctgctgtac atcttcaagc agcctttcat gcgccctgtg      660

cagaccaccc aggaggagga cggctgcagc tgcagattcc cagaggaaga ggaaggcggc      720

tgtgaactg                                                              729


<210>  698
<211>  690
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Synthetic nucleotide

<400>  698
atggactgga cctggattct gtttctggtg gccgccgcta caagagtgca cagcttcctg       60

gattctccag accggccttg gaaccccccc accttctccc cagccctgct ggtggtgaca      120

gagggcgaca acgccacctt cacatgcagc ttttctaata ccagcgagag cttcgtgctg      180

aattggtaca gaatgtcccc tagcaaccag accgacaagc tggccgcttt tcctgaggac      240

agatctcagc ctggacagga ttgcagattc agagtgaccc agctgcctaa cggcagagac      300

ttccacatga gcgtggtcag agccagacgg aacgacagcg gaacatatct gtgcggcgcc      360

atcagcctgg cccctaaggc ccaaatcaag gaaagcctga gagctgaact gagggttacc      420

gagcggcggg ccgaagtgcc cacagcccac tgccctagcc ctctgttccc cggccccagc      480

aaacctttct gggtcctggt ggtggtgggc ggcgtgctgg cttgttacag cctcctggtg      540

accgtggcct tcatcatctt ctgggtgcgg agcaagcgga gtagactgct gcattctgat      600

tacatgaaca tgacccctag acggcctggc cctaccagaa agcactacca gccctacgcc      660

cctccaagag atttcgccgc ctaccgctcc                                       690


<210>  699
<211>  10259
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Synthetic nucleotide

<400>  699
gtcgacggat cgggagatct cccgatcccc tatggtgcac tctcagtaca atctgctctg       60

atgccgcata gttaagccag tatctgctcc ctgcttgtgt gttggaggtc gctgagtagt      120

gcgcgagcaa aatttaagct acaacaaggc aaggcttgac cgacaattgc atgaagaatc      180

tgcttagggt taggcgtttt gcgctgcttc gcgatgtacg ggccagatat acgcgttgac      240

attgattatt gactagttat taatagtaat caattacggg gtcattagtt catagcccat      300

atatggagtt ccgcgttaca taacttacgg taaatggccc gcctggctga ccgcccaacg      360

acccccgccc attgacgtca ataatgacgt atgttcccat agtaacgcca atagggactt      420

tccattgacg tcaatgggtg gagtatttac ggtaaactgc ccacttggca gtacatcaag      480

tgtatcatat gccaagtacg ccccctattg acgtcaatga cggtaaatgg cccgcctggc      540

attatgccca gtacatgacc ttatgggact ttcctacttg gcagtacatc tacgtattag      600

tcatcgctat taccatggtg atgcggtttt ggcagtacat caatgggcgt ggatagcggt      660

ttgactcacg gggatttcca agtctccacc ccattgacgt caatgggagt ttgttttggc      720

accaaaatca acgggacttt ccaaaatgtc gtaacaactc cgccccattg acgcaaatgg      780

gcggtaggcg tgtacggtgg gaggtctata taagcagcgc gttttgcctg tactgggtct      840

ctctggttag accagatctg agcctgggag ctctctggct aactagggaa cccactgctt      900

aagcctcaat aaagcttgcc ttgagtgctt caagtagtgt gtgcccgtct gttgtgtgac      960

tctggtaact agagatccct cagacccttt tagtcagtgt ggaaaatctc tagcagtggc     1020

gcccgaacag ggacttgaaa gcgaaaggga aaccagagga gctctctcga cgcaggactc     1080

ggcttgctga agcgcgcacg gcaagaggcg aggggcggcg actggtgagt acgccaaaaa     1140

ttttgactag cggaggctag aaggagagag atgggtgcga gagcgtcagt attaagcggg     1200

ggagaattag atcgcgatgg gaaaaaattc ggttaaggcc agggggaaag aaaaaatata     1260

aattaaaaca tatagtatgg gcaagcaggg agctagaacg attcgcagtt aatcctggcc     1320

tgttagaaac atcagaaggc tgtagacaaa tactgggaca gctacaacca tcccttcaga     1380

caggatcaga agaacttaga tcattatata atacagtagc aaccctctat tgtgtgcatc     1440

aaaggataga gataaaagac accaaggaag ctttagacaa gatagaggaa gagcaaaaca     1500

aaagtaagac caccgcacag caagcggccg ctgatcttca gacctggagg aggagatatg     1560

agggacaatt ggagaagtga attatataaa tataaagtag taaaaattga accattagga     1620

gtagcaccca ccaaggcaaa gagaagagtg gtgcagagag aaaaaagagc agtgggaata     1680

ggagctttgt tccttgggtt cttgggagca gcaggaagca ctatgggcgc agcgtcaatg     1740

acgctgacgg tacaggccag acaattattg tctggtatag tgcagcagca gaacaatttg     1800

ctgagggcta ttgaggcgca acagcatctg ttgcaactca cagtctgggg catcaagcag     1860

ctccaggcaa gaatcctggc tgtggaaaga tacctaaagg atcaacagct cctggggatt     1920

tggggttgct ctggaaaact catttgcacc actgctgtgc cttggaatgc tagttggagt     1980

aataaatctc tggaacagat ttggaatcac acgacctgga tggagtggga cagagaaatt     2040

aacaattaca caagcttaat acactcctta attgaagaat cgcaaaacca gcaagaaaag     2100

aatgaacaag aattattgga attagataaa tgggcaagtt tgtggaattg gtttaacata     2160

acaaattggc tgtggtatat aaaattattc ataatgatag taggaggctt ggtaggttta     2220

agaatagttt ttgctgtact ttctatagtg aatagagtta ggcagggata ttcaccatta     2280

tcgtttcaga cccacctccc aaccccgagg ggacccgaca ggcccgaagg aatagaagaa     2340

gaaggtggag agagagacag agacagatcc attcgattag tgaacggatc ggcactgcgt     2400

gcgccaattc tgcagacaaa tggcagtatt catccacaat tttaaaagaa aaggggggat     2460

tggggggtac agtgcagggg aaagaatagt agacataata gcaacagaca tacaaactaa     2520

agaattacaa aaacaaatta caaaaattca aaattttcgg gtttattaca gggacagcag     2580

agatccagtt tggttaatta gctagctagg tcttgaaagg agtgggaatt ggctccggtg     2640

cccgtcagtg ggcagagcgc acatcgccca cagtccccga gaagttgggg ggaggggtcg     2700

gcaattgatc cggtgcctag agaaggtggc gcggggtaaa ctgggaaagt gatgtcgtgt     2760

actggctccg cctttttccc gagggtgggg gagaaccgta tataagtgca gtagtcgccg     2820

tgaacgttct ttttcgcaac gggtttgccg ccagaacaca ggaccggttc tagagcgctt     2880

taattaagcc accatggact ggacctggat tctgttcctg gtggccgccg ctacaagagt     2940

gcacagccag gtgaccgaca tcaactccaa gggcctggaa ctgagaaaga ccgtgacaac     3000

cgttgagaca caaaatctgg aaggcctgca ccacgacggc cagttttgcc acaagccttg     3060

tcctccaggc gagcggaagg ccagagattg caccgtgaac ggcgatgagc ctgactgcgt     3120

gccatgtcag gagggcaagg aatacaccga taaggcccac ttcagcagca agtgcaggcg     3180

gtgccggctg tgcgacgagg gccacggact ggaagtggaa atcaactgca ccagaacaca     3240

gaacacaaag tgcagatgca agcccaactt cttctgcaac agcaccgtgt gcgagcattg     3300

tgacccctgc acaaaatgtg aacacggcat catcaaggag tgcaccctga ccagcaacac     3360

caagtgtaaa gaggaaggaa gcagaagcaa tctgggctgg ctgtgtctgc tcctgctgcc     3420

tattcctctg atcgtgtggg tcaagagaaa agaggtgcag aagaagcggg gcagaaagaa     3480

actgctgtac atcttcaagc agccttttat gcggcctgtg cagaccactc aggaggagga     3540

cggctgcagc tgcagattcc ccgaggaaga ggaaggcgga tgtgagctgt gagaattccg     3600

cccccccccc ccccccccct ctccctcccc cccccctaac gttactggcc gaagccgctt     3660

ggaataaggc cggtgtgcgt ttgtctatat gttattttcc accatattgc cgtcttttgg     3720

caatgtgagg gcccggaaac ctggccctgt cttcttgacg agcattccta ggggtctttc     3780

ccctctcgcc aaaggaatgc aaggtctgtt gaatgtcgtg aaggaagcag ttcctctgga     3840

agcttcttga agacaaacaa cgtctgtagc gaccctttgc aggcagcgga accccccacc     3900

tggcgacagg tgcctctgcg gccaaaagcc acgtgtataa gatacacctg caaaggcggc     3960

acaaccccag tgccacgttg tgagttggat agttgtggaa agagtcaaat ggctctcctc     4020

aagcgtattc aacaaggggc tgaaggatgc ccagaaggta ccccattgta tgggatctga     4080

tctggggcct cggtgcacat gctttacatg tgtttagtcg aggttaaaaa aacgtctagg     4140

ccccccgaac cacggggacg tggttttcct ttgaaaaaca cgatgataag cttgatcacg     4200

cgtgccacca tgagcaaggg cgaggagctg ttcaccgggg tggtgcccat cctggtcgag     4260

ctggacggcg acgtaaacgg ccacaagttc agcgtgtccg gcgagggcga gggcgatgcc     4320

acctacggca agctgaccct gaagttcatc tgcaccaccg gcaagctgcc cgtgccctgg     4380

cccaccctcg tgaccaccct gacctacggc gtgcagtgct tcagccgcta ccccgaccac     4440

atgaagcagc acgacttctt caagtccgcc atgcccgaag gctacgtcca ggagcgcacc     4500

atcttcttca aggacgacgg caactacaag acccgcgccg aggtgaagtt cgagggcgac     4560

accctggtga accgcatcga gctgaagggc atcgacttca aggaggacgg caacatcctg     4620

gggcacaagc tggagtacaa ctacaacagc cacaacgtct atatcatggc cgacaagcag     4680

aagaacggca tcaaggtgaa cttcaagatc cgccacaaca tcgaggacgg cagcgtgcag     4740

ctcgccgacc actaccagca gaacaccccc atcggcgacg gccccgtgct gctgcccgac     4800

aaccactacc tgagcaccca gtccgccctg agcaaagacc ccaacgagaa gcgcgatcac     4860

atggtcctgc tggagttcgt gaccgccgcc gggatcactc acggcatgga cgagctgtac     4920

aagtgagaat tcgatatcaa gcttatcggt aatcaacctc tggattacaa aatttgtgaa     4980

agattgactg gtattcttaa ctatgttgct ccttttacgc tatgtggata cgctgcttta     5040

atgcctttgt atcatgctat tgcttcccgt atggctttca ttttctcctc cttgtataaa     5100

tcctggttgc tgtctcttta tgaggagttg tggcccgttg tcaggcaacg tggcgtggtg     5160

tgcactgtgt ttgctgacgc aacccccact ggttggggca ttgccaccac ctgtcagctc     5220

ctttccggga ctttcgcttt ccccctccct attgccacgg cggaactcat cgccgcctgc     5280

cttgcccgct gctggacagg ggctcggctg ttgggcactg acaattccgt ggtgttgtcg     5340

gggaaatcat cgtcctttcc ttggctgctc gcctgtgttg ccacctggat tctgcgcggg     5400

acgtccttct gctacgtccc ttcggccctc aatccagcgg accttccttc ccgcggcctg     5460

ctgccggctc tgcggcctct tccgcgtctt cgccttcgcc ctcagacgag tcggatctcc     5520

ctttgggccg cctccccgca tcgataccgt cgacctcgag acctagaaaa acatggagca     5580

atcacaagta gcaatacagc agctaccaat gctgattgtg cctggctaga agcacaagag     5640

gaggaggagg tgggttttcc agtcacacct caggtacctt taagaccaat gacttacaag     5700

gcagctgtag atcttagcca ctttttaaaa gaaaaggggg gactggaagg gctaattcac     5760

tcccaacgaa gacaagatat ccttgatctg tggatctacc acacacaagg ctacttccct     5820

gattggcaga actacacacc agggccaggg atcagatatc cactgacctt tggatggtgc     5880

tacaagctag taccagttga gcaagagaag gtagaagaag ccaatgaagg agagaacacc     5940

cgcttgttac accctgtgag cctgcatggg atggatgacc cggagagaga agtattagag     6000

tggaggtttg acagccgcct agcatttcat cacatggccc gagagctgca tccggactgt     6060

actgggtctc tctggttaga ccagatctga gcctgggagc tctctggcta actagggaac     6120

ccactgctta agcctcaata aagcttgcct tgagtgcttc aagtagtgtg tgcccgtctg     6180

ttgtgtgact ctggtaacta gagatccctc agaccctttt agtcagtgtg gaaaatctct     6240

agcagggccc gtttaaaccc gctgatcagc ctcgactgtg ccttctagtt gccagccatc     6300

tgttgtttgc ccctcccccg tgccttcctt gaccctggaa ggtgccactc ccactgtcct     6360

ttcctaataa aatgaggaaa ttgcatcgca ttgtctgagt aggtgtcatt ctattctggg     6420

gggtggggtg gggcaggaca gcaaggggga ggattgggaa gacaatagca ggcatgctgg     6480

ggatgcggtg ggctctatgg cttctgaggc ggaaagaacc agctggggct ctagggggta     6540

tccccacgcg ccctgtagcg gcgcattaag cgcggcgggt gtggtggtta cgcgcagcgt     6600

gaccgctaca cttgccagcg ccctagcgcc cgctcctttc gctttcttcc cttcctttct     6660

cgccacgttc gccggctttc cccgtcaagc tctaaatcgg gggctccctt tagggttccg     6720

atttagtgct ttacggcacc tcgaccccaa aaaacttgat tagggtgatg gttcacgtag     6780

tgggccatcg ccctgataga cggtttttcg ccctttgacg ttggagtcca cgttctttaa     6840

tagtggactc ttgttccaaa ctggaacaac actcaaccct atctcggtct attcttttga     6900

tttataaggg attttgccga tttcggccta ttggttaaaa aatgagctga tttaacaaaa     6960

atttaacgcg aattaattct gtggaatgtg tgtcagttag ggtgtggaaa gtccccaggc     7020

tccccagcag gcagaagtat gcaaagcatg catctcaatt agtcagcaac caggtgtgga     7080

aagtccccag gctccccagc aggcagaagt atgcaaagca tgcatctcaa ttagtcagca     7140

accatagtcc cgcccctaac tccgcccatc ccgcccctaa ctccgcccag ttccgcccat     7200

tctccgcccc atggctgact aatttttttt atttatgcag aggccgaggc cgcctctgcc     7260

tctgagctat tccagaagta gtgaggaggc ttttttggag gcctaggctt ttgcaaaaag     7320

ctcccgggag cttgtatatc cattttcgga tctgatcagc acgtgttgac aattaatcat     7380

cggcatagta tatcggcata gtataatacg acaaggtgag gaactaaacc atggccaagt     7440

tgaccagtgc cgttccggtg ctcaccgcgc gcgacgtcgc cggagcggtc gagttctgga     7500

ccgaccggct cgggttctcc cgggacttcg tggaggacga cttcgccggt gtggtccggg     7560

acgacgtgac cctgttcatc agcgcggtcc aggaccaggt ggtgccggac aacaccctgg     7620

cctgggtgtg ggtgcgcggc ctggacgagc tgtacgccga gtggtcggag gtcgtgtcca     7680

cgaacttccg ggacgcctcc gggccggcca tgaccgagat cggcgagcag ccgtgggggc     7740

gggagttcgc cctgcgcgac ccggccggca actgcgtgca cttcgtggcc gaggagcagg     7800

actgacacgt gctacgagat ttcgattcca ccgccgcctt ctatgaaagg ttgggcttcg     7860

gaatcgtttt ccgggacgcc ggctggatga tcctccagcg cggggatctc atgctggagt     7920

tcttcgccca ccccaacttg tttattgcag cttataatgg ttacaaataa agcaatagca     7980

tcacaaattt cacaaataaa gcattttttt cactgcattc tagttgtggt ttgtccaaac     8040

tcatcaatgt atcttatcat gtctgtatac cgtcgacctc tagctagagc ttggcgtaat     8100

catggtcata gctgtttcct gtgtgaaatt gttatccgct cacaattcca cacaacatac     8160

gagccggaag cataaagtgt aaagcctggg gtgcctaatg agtgagctaa ctcacattaa     8220

ttgcgttgcg ctcactgccc gctttccagt cgggaaacct gtcgtgccag ctgcattaat     8280

gaatcggcca acgcgcgggg agaggcggtt tgcgtattgg gcgctcttcc gcttcctcgc     8340

tcactgactc gctgcgctcg gtcgttcggc tgcggcgagc ggtatcagct cactcaaagg     8400

cggtaatacg gttatccaca gaatcagggg ataacgcagg aaagaacatg tgagcaaaag     8460

gccagcaaaa ggccaggaac cgtaaaaagg ccgcgttgct ggcgtttttc cataggctcc     8520

gcccccctga cgagcatcac aaaaatcgac gctcaagtca gaggtggcga aacccgacag     8580

gactataaag ataccaggcg tttccccctg gaagctccct cgtgcgctct cctgttccga     8640

ccctgccgct taccggatac ctgtccgcct ttctcccttc gggaagcgtg gcgctttctc     8700

atagctcacg ctgtaggtat ctcagttcgg tgtaggtcgt tcgctccaag ctgggctgtg     8760

tgcacgaacc ccccgttcag cccgaccgct gcgccttatc cggtaactat cgtcttgagt     8820

ccaacccggt aagacacgac ttatcgccac tggcagcagc cactggtaac aggattagca     8880

gagcgaggta tgtaggcggt gctacagagt tcttgaagtg gtggcctaac tacggctaca     8940

ctagaagaac agtatttggt atctgcgctc tgctgaagcc agttaccttc ggaaaaagag     9000

ttggtagctc ttgatccggc aaacaaacca ccgctggtag cggtggtttt tttgtttgca     9060

agcagcagat tacgcgcaga aaaaaaggat ctcaagaaga tcctttgatc ttttctacgg     9120

ggtctgacgc tcagtggaac gaaaactcac gttaagggat tttggtcatg agattatcaa     9180

aaaggatctt cacctagatc cttttaaatt aaaaatgaag ttttaaatca atctaaagta     9240

tatatgagta aacttggtct gacagttacc aatgcttaat cagtgaggca cctatctcag     9300

cgatctgtct atttcgttca tccatagttg cctgactccc cgtcgtgtag ataactacga     9360

tacgggaggg cttaccatct ggccccagtg ctgcaatgat accgcgagac ccacgctcac     9420

cggctccaga tttatcagca ataaaccagc cagccggaag ggccgagcgc agaagtggtc     9480

ctgcaacttt atccgcctcc atccagtcta ttaattgttg ccgggaagct agagtaagta     9540

gttcgccagt taatagtttg cgcaacgttg ttgccattgc tacaggcatc gtggtgtcac     9600

gctcgtcgtt tggtatggct tcattcagct ccggttccca acgatcaagg cgagttacat     9660

gatcccccat gttgtgcaaa aaagcggtta gctccttcgg tcctccgatc gttgtcagaa     9720

gtaagttggc cgcagtgtta tcactcatgg ttatggcagc actgcataat tctcttactg     9780

tcatgccatc cgtaagatgc ttttctgtga ctggtgagta ctcaaccaag tcattctgag     9840

aatagtgtat gcggcgaccg agttgctctt gcccggcgtc aatacgggat aataccgcgc     9900

cacatagcag aactttaaaa gtgctcatca ttggaaaacg ttcttcgggg cgaaaactct     9960

caaggatctt accgctgttg agatccagtt cgatgtaacc cactcgtgca cccaactgat    10020

cttcagcatc ttttactttc accagcgttt ctgggtgagc aaaaacagga aggcaaaatg    10080

ccgcaaaaaa gggaataagg gcgacacgga aatgttgaat actcatactc ttcctttttc    10140

aatattattg aagcatttat cagggttatt gtctcatgag cggatacata tttgaatgta    10200

tttagaaaaa taaacaaata ggggttccgc gcacatttcc ccgaaaagtg ccacctgac     10259


<210>  700
<211>  10256
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Synthetic nucleotide

<400>  700
gtcgacggat cgggagatct cccgatcccc tatggtgcac tctcagtaca atctgctctg       60

atgccgcata gttaagccag tatctgctcc ctgcttgtgt gttggaggtc gctgagtagt      120

gcgcgagcaa aatttaagct acaacaaggc aaggcttgac cgacaattgc atgaagaatc      180

tgcttagggt taggcgtttt gcgctgcttc gcgatgtacg ggccagatat acgcgttgac      240

attgattatt gactagttat taatagtaat caattacggg gtcattagtt catagcccat      300

atatggagtt ccgcgttaca taacttacgg taaatggccc gcctggctga ccgcccaacg      360

acccccgccc attgacgtca ataatgacgt atgttcccat agtaacgcca atagggactt      420

tccattgacg tcaatgggtg gagtatttac ggtaaactgc ccacttggca gtacatcaag      480

tgtatcatat gccaagtacg ccccctattg acgtcaatga cggtaaatgg cccgcctggc      540

attatgccca gtacatgacc ttatgggact ttcctacttg gcagtacatc tacgtattag      600

tcatcgctat taccatggtg atgcggtttt ggcagtacat caatgggcgt ggatagcggt      660

ttgactcacg gggatttcca agtctccacc ccattgacgt caatgggagt ttgttttggc      720

accaaaatca acgggacttt ccaaaatgtc gtaacaactc cgccccattg acgcaaatgg      780

gcggtaggcg tgtacggtgg gaggtctata taagcagcgc gttttgcctg tactgggtct      840

ctctggttag accagatctg agcctgggag ctctctggct aactagggaa cccactgctt      900

aagcctcaat aaagcttgcc ttgagtgctt caagtagtgt gtgcccgtct gttgtgtgac      960

tctggtaact agagatccct cagacccttt tagtcagtgt ggaaaatctc tagcagtggc     1020

gcccgaacag ggacttgaaa gcgaaaggga aaccagagga gctctctcga cgcaggactc     1080

ggcttgctga agcgcgcacg gcaagaggcg aggggcggcg actggtgagt acgccaaaaa     1140

ttttgactag cggaggctag aaggagagag atgggtgcga gagcgtcagt attaagcggg     1200

ggagaattag atcgcgatgg gaaaaaattc ggttaaggcc agggggaaag aaaaaatata     1260

aattaaaaca tatagtatgg gcaagcaggg agctagaacg attcgcagtt aatcctggcc     1320

tgttagaaac atcagaaggc tgtagacaaa tactgggaca gctacaacca tcccttcaga     1380

caggatcaga agaacttaga tcattatata atacagtagc aaccctctat tgtgtgcatc     1440

aaaggataga gataaaagac accaaggaag ctttagacaa gatagaggaa gagcaaaaca     1500

aaagtaagac caccgcacag caagcggccg ctgatcttca gacctggagg aggagatatg     1560

agggacaatt ggagaagtga attatataaa tataaagtag taaaaattga accattagga     1620

gtagcaccca ccaaggcaaa gagaagagtg gtgcagagag aaaaaagagc agtgggaata     1680

ggagctttgt tccttgggtt cttgggagca gcaggaagca ctatgggcgc agcgtcaatg     1740

acgctgacgg tacaggccag acaattattg tctggtatag tgcagcagca gaacaatttg     1800

ctgagggcta ttgaggcgca acagcatctg ttgcaactca cagtctgggg catcaagcag     1860

ctccaggcaa gaatcctggc tgtggaaaga tacctaaagg atcaacagct cctggggatt     1920

tggggttgct ctggaaaact catttgcacc actgctgtgc cttggaatgc tagttggagt     1980

aataaatctc tggaacagat ttggaatcac acgacctgga tggagtggga cagagaaatt     2040

aacaattaca caagcttaat acactcctta attgaagaat cgcaaaacca gcaagaaaag     2100

aatgaacaag aattattgga attagataaa tgggcaagtt tgtggaattg gtttaacata     2160

acaaattggc tgtggtatat aaaattattc ataatgatag taggaggctt ggtaggttta     2220

agaatagttt ttgctgtact ttctatagtg aatagagtta ggcagggata ttcaccatta     2280

tcgtttcaga cccacctccc aaccccgagg ggacccgaca ggcccgaagg aatagaagaa     2340

gaaggtggag agagagacag agacagatcc attcgattag tgaacggatc ggcactgcgt     2400

gcgccaattc tgcagacaaa tggcagtatt catccacaat tttaaaagaa aaggggggat     2460

tggggggtac agtgcagggg aaagaatagt agacataata gcaacagaca tacaaactaa     2520

agaattacaa aaacaaatta caaaaattca aaattttcgg gtttattaca gggacagcag     2580

agatccagtt tggttaatta gctagctagg tcttgaaagg agtgggaatt ggctccggtg     2640

cccgtcagtg ggcagagcgc acatcgccca cagtccccga gaagttgggg ggaggggtcg     2700

gcaattgatc cggtgcctag agaaggtggc gcggggtaaa ctgggaaagt gatgtcgtgt     2760

actggctccg cctttttccc gagggtgggg gagaaccgta tataagtgca gtagtcgccg     2820

tgaacgttct ttttcgcaac gggtttgccg ccagaacaca ggaccggttc tagagcgctt     2880

taattaagcc accatggact ggacctggat tctgttcctg gtcgccgccg ccacaagagt     2940

gcattctttt ctggacagcc ctgatagacc ttggaaccct ccaacctttt cccccgccct     3000

gctggtggtg accgagggcg acaacgccac cttcacctgt agcttttcca ataccagcga     3060

gagcttcgtg ctgaactggt acagaatgtc tcctagcaac cagaccgaca agctggccgc     3120

ttttcctgag gacagatccc agcccggcca ggactgcaga ttcagagtga cccagctgcc     3180

taacggcaga gatttccaca tgagcgtggt gagagccaga agaaacgaca gcggcaccta     3240

cctgtgcgga gccatcagcc tggctcctaa ggcccagatt aaggaatctc tgagagccga     3300

gctgagggtg acagagagaa gagctgaagt gcctacagcc caccccgccc cagctcgcga     3360

gcctggacac agccctcaga tcatctcttt cttcctggcc ctgaccagca ccgccctgct     3420

cttcctgctc ttcttcctga cactgcggtt cagcgttgtg aaacggggcc gaaaaaagct     3480

gctgtacatc ttcaagcagc ctttcatgcg gcccgtgcaa acaacacagg aggaagatgg     3540

ctgcagctgc cggttccccg aggaagagga aggcggctgt gaactgtgag aattccgccc     3600

cccccccccc cccccctctc cctccccccc ccctaacgtt actggccgaa gccgcttgga     3660

ataaggccgg tgtgcgtttg tctatatgtt attttccacc atattgccgt cttttggcaa     3720

tgtgagggcc cggaaacctg gccctgtctt cttgacgagc attcctaggg gtctttcccc     3780

tctcgccaaa ggaatgcaag gtctgttgaa tgtcgtgaag gaagcagttc ctctggaagc     3840

ttcttgaaga caaacaacgt ctgtagcgac cctttgcagg cagcggaacc ccccacctgg     3900

cgacaggtgc ctctgcggcc aaaagccacg tgtataagat acacctgcaa aggcggcaca     3960

accccagtgc cacgttgtga gttggatagt tgtggaaaga gtcaaatggc tctcctcaag     4020

cgtattcaac aaggggctga aggatgccca gaaggtaccc cattgtatgg gatctgatct     4080

ggggcctcgg tgcacatgct ttacatgtgt ttagtcgagg ttaaaaaaac gtctaggccc     4140

cccgaaccac ggggacgtgg ttttcctttg aaaaacacga tgataagctt gatcacgcgt     4200

gccaccatga gcaagggcga ggagctgttc accggggtgg tgcccatcct ggtcgagctg     4260

gacggcgacg taaacggcca caagttcagc gtgtccggcg agggcgaggg cgatgccacc     4320

tacggcaagc tgaccctgaa gttcatctgc accaccggca agctgcccgt gccctggccc     4380

accctcgtga ccaccctgac ctacggcgtg cagtgcttca gccgctaccc cgaccacatg     4440

aagcagcacg acttcttcaa gtccgccatg cccgaaggct acgtccagga gcgcaccatc     4500

ttcttcaagg acgacggcaa ctacaagacc cgcgccgagg tgaagttcga gggcgacacc     4560

ctggtgaacc gcatcgagct gaagggcatc gacttcaagg aggacggcaa catcctgggg     4620

cacaagctgg agtacaacta caacagccac aacgtctata tcatggccga caagcagaag     4680

aacggcatca aggtgaactt caagatccgc cacaacatcg aggacggcag cgtgcagctc     4740

gccgaccact accagcagaa cacccccatc ggcgacggcc ccgtgctgct gcccgacaac     4800

cactacctga gcacccagtc cgccctgagc aaagacccca acgagaagcg cgatcacatg     4860

gtcctgctgg agttcgtgac cgccgccggg atcactcacg gcatggacga gctgtacaag     4920

tgagaattcg atatcaagct tatcggtaat caacctctgg attacaaaat ttgtgaaaga     4980

ttgactggta ttcttaacta tgttgctcct tttacgctat gtggatacgc tgctttaatg     5040

cctttgtatc atgctattgc ttcccgtatg gctttcattt tctcctcctt gtataaatcc     5100

tggttgctgt ctctttatga ggagttgtgg cccgttgtca ggcaacgtgg cgtggtgtgc     5160

actgtgtttg ctgacgcaac ccccactggt tggggcattg ccaccacctg tcagctcctt     5220

tccgggactt tcgctttccc cctccctatt gccacggcgg aactcatcgc cgcctgcctt     5280

gcccgctgct ggacaggggc tcggctgttg ggcactgaca attccgtggt gttgtcgggg     5340

aaatcatcgt cctttccttg gctgctcgcc tgtgttgcca cctggattct gcgcgggacg     5400

tccttctgct acgtcccttc ggccctcaat ccagcggacc ttccttcccg cggcctgctg     5460

ccggctctgc ggcctcttcc gcgtcttcgc cttcgccctc agacgagtcg gatctccctt     5520

tgggccgcct ccccgcatcg ataccgtcga cctcgagacc tagaaaaaca tggagcaatc     5580

acaagtagca atacagcagc taccaatgct gattgtgcct ggctagaagc acaagaggag     5640

gaggaggtgg gttttccagt cacacctcag gtacctttaa gaccaatgac ttacaaggca     5700

gctgtagatc ttagccactt tttaaaagaa aaggggggac tggaagggct aattcactcc     5760

caacgaagac aagatatcct tgatctgtgg atctaccaca cacaaggcta cttccctgat     5820

tggcagaact acacaccagg gccagggatc agatatccac tgacctttgg atggtgctac     5880

aagctagtac cagttgagca agagaaggta gaagaagcca atgaaggaga gaacacccgc     5940

ttgttacacc ctgtgagcct gcatgggatg gatgacccgg agagagaagt attagagtgg     6000

aggtttgaca gccgcctagc atttcatcac atggcccgag agctgcatcc ggactgtact     6060

gggtctctct ggttagacca gatctgagcc tgggagctct ctggctaact agggaaccca     6120

ctgcttaagc ctcaataaag cttgccttga gtgcttcaag tagtgtgtgc ccgtctgttg     6180

tgtgactctg gtaactagag atccctcaga cccttttagt cagtgtggaa aatctctagc     6240

agggcccgtt taaacccgct gatcagcctc gactgtgcct tctagttgcc agccatctgt     6300

tgtttgcccc tcccccgtgc cttccttgac cctggaaggt gccactccca ctgtcctttc     6360

ctaataaaat gaggaaattg catcgcattg tctgagtagg tgtcattcta ttctgggggg     6420

tggggtgggg caggacagca agggggagga ttgggaagac aatagcaggc atgctgggga     6480

tgcggtgggc tctatggctt ctgaggcgga aagaaccagc tggggctcta gggggtatcc     6540

ccacgcgccc tgtagcggcg cattaagcgc ggcgggtgtg gtggttacgc gcagcgtgac     6600

cgctacactt gccagcgccc tagcgcccgc tcctttcgct ttcttccctt cctttctcgc     6660

cacgttcgcc ggctttcccc gtcaagctct aaatcggggg ctccctttag ggttccgatt     6720

tagtgcttta cggcacctcg accccaaaaa acttgattag ggtgatggtt cacgtagtgg     6780

gccatcgccc tgatagacgg tttttcgccc tttgacgttg gagtccacgt tctttaatag     6840

tggactcttg ttccaaactg gaacaacact caaccctatc tcggtctatt cttttgattt     6900

ataagggatt ttgccgattt cggcctattg gttaaaaaat gagctgattt aacaaaaatt     6960

taacgcgaat taattctgtg gaatgtgtgt cagttagggt gtggaaagtc cccaggctcc     7020

ccagcaggca gaagtatgca aagcatgcat ctcaattagt cagcaaccag gtgtggaaag     7080

tccccaggct ccccagcagg cagaagtatg caaagcatgc atctcaatta gtcagcaacc     7140

atagtcccgc ccctaactcc gcccatcccg cccctaactc cgcccagttc cgcccattct     7200

ccgccccatg gctgactaat tttttttatt tatgcagagg ccgaggccgc ctctgcctct     7260

gagctattcc agaagtagtg aggaggcttt tttggaggcc taggcttttg caaaaagctc     7320

ccgggagctt gtatatccat tttcggatct gatcagcacg tgttgacaat taatcatcgg     7380

catagtatat cggcatagta taatacgaca aggtgaggaa ctaaaccatg gccaagttga     7440

ccagtgccgt tccggtgctc accgcgcgcg acgtcgccgg agcggtcgag ttctggaccg     7500

accggctcgg gttctcccgg gacttcgtgg aggacgactt cgccggtgtg gtccgggacg     7560

acgtgaccct gttcatcagc gcggtccagg accaggtggt gccggacaac accctggcct     7620

gggtgtgggt gcgcggcctg gacgagctgt acgccgagtg gtcggaggtc gtgtccacga     7680

acttccggga cgcctccggg ccggccatga ccgagatcgg cgagcagccg tgggggcggg     7740

agttcgccct gcgcgacccg gccggcaact gcgtgcactt cgtggccgag gagcaggact     7800

gacacgtgct acgagatttc gattccaccg ccgccttcta tgaaaggttg ggcttcggaa     7860

tcgttttccg ggacgccggc tggatgatcc tccagcgcgg ggatctcatg ctggagttct     7920

tcgcccaccc caacttgttt attgcagctt ataatggtta caaataaagc aatagcatca     7980

caaatttcac aaataaagca tttttttcac tgcattctag ttgtggtttg tccaaactca     8040

tcaatgtatc ttatcatgtc tgtataccgt cgacctctag ctagagcttg gcgtaatcat     8100

ggtcatagct gtttcctgtg tgaaattgtt atccgctcac aattccacac aacatacgag     8160

ccggaagcat aaagtgtaaa gcctggggtg cctaatgagt gagctaactc acattaattg     8220

cgttgcgctc actgcccgct ttccagtcgg gaaacctgtc gtgccagctg cattaatgaa     8280

tcggccaacg cgcggggaga ggcggtttgc gtattgggcg ctcttccgct tcctcgctca     8340

ctgactcgct gcgctcggtc gttcggctgc ggcgagcggt atcagctcac tcaaaggcgg     8400

taatacggtt atccacagaa tcaggggata acgcaggaaa gaacatgtga gcaaaaggcc     8460

agcaaaaggc caggaaccgt aaaaaggccg cgttgctggc gtttttccat aggctccgcc     8520

cccctgacga gcatcacaaa aatcgacgct caagtcagag gtggcgaaac ccgacaggac     8580

tataaagata ccaggcgttt ccccctggaa gctccctcgt gcgctctcct gttccgaccc     8640

tgccgcttac cggatacctg tccgcctttc tcccttcggg aagcgtggcg ctttctcata     8700

gctcacgctg taggtatctc agttcggtgt aggtcgttcg ctccaagctg ggctgtgtgc     8760

acgaaccccc cgttcagccc gaccgctgcg ccttatccgg taactatcgt cttgagtcca     8820

acccggtaag acacgactta tcgccactgg cagcagccac tggtaacagg attagcagag     8880

cgaggtatgt aggcggtgct acagagttct tgaagtggtg gcctaactac ggctacacta     8940

gaagaacagt atttggtatc tgcgctctgc tgaagccagt taccttcgga aaaagagttg     9000

gtagctcttg atccggcaaa caaaccaccg ctggtagcgg tggttttttt gtttgcaagc     9060

agcagattac gcgcagaaaa aaaggatctc aagaagatcc tttgatcttt tctacggggt     9120

ctgacgctca gtggaacgaa aactcacgtt aagggatttt ggtcatgaga ttatcaaaaa     9180

ggatcttcac ctagatcctt ttaaattaaa aatgaagttt taaatcaatc taaagtatat     9240

atgagtaaac ttggtctgac agttaccaat gcttaatcag tgaggcacct atctcagcga     9300

tctgtctatt tcgttcatcc atagttgcct gactccccgt cgtgtagata actacgatac     9360

gggagggctt accatctggc cccagtgctg caatgatacc gcgagaccca cgctcaccgg     9420

ctccagattt atcagcaata aaccagccag ccggaagggc cgagcgcaga agtggtcctg     9480

caactttatc cgcctccatc cagtctatta attgttgccg ggaagctaga gtaagtagtt     9540

cgccagttaa tagtttgcgc aacgttgttg ccattgctac aggcatcgtg gtgtcacgct     9600

cgtcgtttgg tatggcttca ttcagctccg gttcccaacg atcaaggcga gttacatgat     9660

cccccatgtt gtgcaaaaaa gcggttagct ccttcggtcc tccgatcgtt gtcagaagta     9720

agttggccgc agtgttatca ctcatggtta tggcagcact gcataattct cttactgtca     9780

tgccatccgt aagatgcttt tctgtgactg gtgagtactc aaccaagtca ttctgagaat     9840

agtgtatgcg gcgaccgagt tgctcttgcc cggcgtcaat acgggataat accgcgccac     9900

atagcagaac tttaaaagtg ctcatcattg gaaaacgttc ttcggggcga aaactctcaa     9960

ggatcttacc gctgttgaga tccagttcga tgtaacccac tcgtgcaccc aactgatctt    10020

cagcatcttt tactttcacc agcgtttctg ggtgagcaaa aacaggaagg caaaatgccg    10080

caaaaaaggg aataagggcg acacggaaat gttgaatact catactcttc ctttttcaat    10140

attattgaag catttatcag ggttattgtc tcatgagcgg atacatattt gaatgtattt    10200

agaaaaataa acaaataggg gttccgcgca catttccccg aaaagtgcca cctgac        10256


<210>  701
<211>  10292
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Synthetic nucleotide

<400>  701
gtcgacggat cgggagatct cccgatcccc tatggtgcac tctcagtaca atctgctctg       60

atgccgcata gttaagccag tatctgctcc ctgcttgtgt gttggaggtc gctgagtagt      120

gcgcgagcaa aatttaagct acaacaaggc aaggcttgac cgacaattgc atgaagaatc      180

tgcttagggt taggcgtttt gcgctgcttc gcgatgtacg ggccagatat acgcgttgac      240

attgattatt gactagttat taatagtaat caattacggg gtcattagtt catagcccat      300

atatggagtt ccgcgttaca taacttacgg taaatggccc gcctggctga ccgcccaacg      360

acccccgccc attgacgtca ataatgacgt atgttcccat agtaacgcca atagggactt      420

tccattgacg tcaatgggtg gagtatttac ggtaaactgc ccacttggca gtacatcaag      480

tgtatcatat gccaagtacg ccccctattg acgtcaatga cggtaaatgg cccgcctggc      540

attatgccca gtacatgacc ttatgggact ttcctacttg gcagtacatc tacgtattag      600

tcatcgctat taccatggtg atgcggtttt ggcagtacat caatgggcgt ggatagcggt      660

ttgactcacg gggatttcca agtctccacc ccattgacgt caatgggagt ttgttttggc      720

accaaaatca acgggacttt ccaaaatgtc gtaacaactc cgccccattg acgcaaatgg      780

gcggtaggcg tgtacggtgg gaggtctata taagcagcgc gttttgcctg tactgggtct      840

ctctggttag accagatctg agcctgggag ctctctggct aactagggaa cccactgctt      900

aagcctcaat aaagcttgcc ttgagtgctt caagtagtgt gtgcccgtct gttgtgtgac      960

tctggtaact agagatccct cagacccttt tagtcagtgt ggaaaatctc tagcagtggc     1020

gcccgaacag ggacttgaaa gcgaaaggga aaccagagga gctctctcga cgcaggactc     1080

ggcttgctga agcgcgcacg gcaagaggcg aggggcggcg actggtgagt acgccaaaaa     1140

ttttgactag cggaggctag aaggagagag atgggtgcga gagcgtcagt attaagcggg     1200

ggagaattag atcgcgatgg gaaaaaattc ggttaaggcc agggggaaag aaaaaatata     1260

aattaaaaca tatagtatgg gcaagcaggg agctagaacg attcgcagtt aatcctggcc     1320

tgttagaaac atcagaaggc tgtagacaaa tactgggaca gctacaacca tcccttcaga     1380

caggatcaga agaacttaga tcattatata atacagtagc aaccctctat tgtgtgcatc     1440

aaaggataga gataaaagac accaaggaag ctttagacaa gatagaggaa gagcaaaaca     1500

aaagtaagac caccgcacag caagcggccg ctgatcttca gacctggagg aggagatatg     1560

agggacaatt ggagaagtga attatataaa tataaagtag taaaaattga accattagga     1620

gtagcaccca ccaaggcaaa gagaagagtg gtgcagagag aaaaaagagc agtgggaata     1680

ggagctttgt tccttgggtt cttgggagca gcaggaagca ctatgggcgc agcgtcaatg     1740

acgctgacgg tacaggccag acaattattg tctggtatag tgcagcagca gaacaatttg     1800

ctgagggcta ttgaggcgca acagcatctg ttgcaactca cagtctgggg catcaagcag     1860

ctccaggcaa gaatcctggc tgtggaaaga tacctaaagg atcaacagct cctggggatt     1920

tggggttgct ctggaaaact catttgcacc actgctgtgc cttggaatgc tagttggagt     1980

aataaatctc tggaacagat ttggaatcac acgacctgga tggagtggga cagagaaatt     2040

aacaattaca caagcttaat acactcctta attgaagaat cgcaaaacca gcaagaaaag     2100

aatgaacaag aattattgga attagataaa tgggcaagtt tgtggaattg gtttaacata     2160

acaaattggc tgtggtatat aaaattattc ataatgatag taggaggctt ggtaggttta     2220

agaatagttt ttgctgtact ttctatagtg aatagagtta ggcagggata ttcaccatta     2280

tcgtttcaga cccacctccc aaccccgagg ggacccgaca ggcccgaagg aatagaagaa     2340

gaaggtggag agagagacag agacagatcc attcgattag tgaacggatc ggcactgcgt     2400

gcgccaattc tgcagacaaa tggcagtatt catccacaat tttaaaagaa aaggggggat     2460

tggggggtac agtgcagggg aaagaatagt agacataata gcaacagaca tacaaactaa     2520

agaattacaa aaacaaatta caaaaattca aaattttcgg gtttattaca gggacagcag     2580

agatccagtt tggttaatta gctagctagg tcttgaaagg agtgggaatt ggctccggtg     2640

cccgtcagtg ggcagagcgc acatcgccca cagtccccga gaagttgggg ggaggggtcg     2700

gcaattgatc cggtgcctag agaaggtggc gcggggtaaa ctgggaaagt gatgtcgtgt     2760

actggctccg cctttttccc gagggtgggg gagaaccgta tataagtgca gtagtcgccg     2820

tgaacgttct ttttcgcaac gggtttgccg ccagaacaca ggaccggttc tagagcgctt     2880

taattaagcc accatggact ggacctggat tctgtttctg gtcgccgccg ctacaagagt     2940

tcacagcacc atccctcctc atgtgcaaaa atccgtgaac aacgacatga tcgtgaccga     3000

caataacggc gccgtcaaat tcccccagct gtgcaagttc tgcgacgtgc ggttttctac     3060

atgtgataac cagaagtcct gcatgagcaa ctgcagcatc acaagcatct gcgagaaacc     3120

tcaggaggtg tgcgtggccg tgtggcggaa gaacgacgag aacatcaccc tggaaaccgt     3180

gtgtcacgac cccaagctgc cttaccacga cttcatcctg gaagatgccg cctctccaaa     3240

gtgcatcatg aaggaaaaga aaaagcccgg cgagaccttc ttcatgtgct cttgttctag     3300

cgatgagtgc aatgataaca tcattttcag cgaggaatac aacaccagca atcccgacct     3360

gctgctcgtg atctttcagc ccgcccctgc tagagagcct ggacactccc ctcagatcat     3420

cagcttcttc ctggccctga caagcacagc cctgctgttt ctgctgttct tcctgaccct     3480

gagattcagc gtggtgaagc ggggaagaaa gaagctgctg tacatcttca agcagccttt     3540

catgcgccct gtgcagacca cccaggagga ggacggctgc agctgcagat tcccagagga     3600

agaggaaggc ggctgtgaac tgtgagaatt ccgccccccc cccccccccc cctctccctc     3660

ccccccccct aacgttactg gccgaagccg cttggaataa ggccggtgtg cgtttgtcta     3720

tatgttattt tccaccatat tgccgtcttt tggcaatgtg agggcccgga aacctggccc     3780

tgtcttcttg acgagcattc ctaggggtct ttcccctctc gccaaaggaa tgcaaggtct     3840

gttgaatgtc gtgaaggaag cagttcctct ggaagcttct tgaagacaaa caacgtctgt     3900

agcgaccctt tgcaggcagc ggaacccccc acctggcgac aggtgcctct gcggccaaaa     3960

gccacgtgta taagatacac ctgcaaaggc ggcacaaccc cagtgccacg ttgtgagttg     4020

gatagttgtg gaaagagtca aatggctctc ctcaagcgta ttcaacaagg ggctgaagga     4080

tgcccagaag gtaccccatt gtatgggatc tgatctgggg cctcggtgca catgctttac     4140

atgtgtttag tcgaggttaa aaaaacgtct aggccccccg aaccacgggg acgtggtttt     4200

cctttgaaaa acacgatgat aagcttgatc acgcgtgcca ccatgagcaa gggcgaggag     4260

ctgttcaccg gggtggtgcc catcctggtc gagctggacg gcgacgtaaa cggccacaag     4320

ttcagcgtgt ccggcgaggg cgagggcgat gccacctacg gcaagctgac cctgaagttc     4380

atctgcacca ccggcaagct gcccgtgccc tggcccaccc tcgtgaccac cctgacctac     4440

ggcgtgcagt gcttcagccg ctaccccgac cacatgaagc agcacgactt cttcaagtcc     4500

gccatgcccg aaggctacgt ccaggagcgc accatcttct tcaaggacga cggcaactac     4560

aagacccgcg ccgaggtgaa gttcgagggc gacaccctgg tgaaccgcat cgagctgaag     4620

ggcatcgact tcaaggagga cggcaacatc ctggggcaca agctggagta caactacaac     4680

agccacaacg tctatatcat ggccgacaag cagaagaacg gcatcaaggt gaacttcaag     4740

atccgccaca acatcgagga cggcagcgtg cagctcgccg accactacca gcagaacacc     4800

cccatcggcg acggccccgt gctgctgccc gacaaccact acctgagcac ccagtccgcc     4860

ctgagcaaag accccaacga gaagcgcgat cacatggtcc tgctggagtt cgtgaccgcc     4920

gccgggatca ctcacggcat ggacgagctg tacaagtgag aattcgatat caagcttatc     4980

ggtaatcaac ctctggatta caaaatttgt gaaagattga ctggtattct taactatgtt     5040

gctcctttta cgctatgtgg atacgctgct ttaatgcctt tgtatcatgc tattgcttcc     5100

cgtatggctt tcattttctc ctccttgtat aaatcctggt tgctgtctct ttatgaggag     5160

ttgtggcccg ttgtcaggca acgtggcgtg gtgtgcactg tgtttgctga cgcaaccccc     5220

actggttggg gcattgccac cacctgtcag ctcctttccg ggactttcgc tttccccctc     5280

cctattgcca cggcggaact catcgccgcc tgccttgccc gctgctggac aggggctcgg     5340

ctgttgggca ctgacaattc cgtggtgttg tcggggaaat catcgtcctt tccttggctg     5400

ctcgcctgtg ttgccacctg gattctgcgc gggacgtcct tctgctacgt cccttcggcc     5460

ctcaatccag cggaccttcc ttcccgcggc ctgctgccgg ctctgcggcc tcttccgcgt     5520

cttcgccttc gccctcagac gagtcggatc tccctttggg ccgcctcccc gcatcgatac     5580

cgtcgacctc gagacctaga aaaacatgga gcaatcacaa gtagcaatac agcagctacc     5640

aatgctgatt gtgcctggct agaagcacaa gaggaggagg aggtgggttt tccagtcaca     5700

cctcaggtac ctttaagacc aatgacttac aaggcagctg tagatcttag ccacttttta     5760

aaagaaaagg ggggactgga agggctaatt cactcccaac gaagacaaga tatccttgat     5820

ctgtggatct accacacaca aggctacttc cctgattggc agaactacac accagggcca     5880

gggatcagat atccactgac ctttggatgg tgctacaagc tagtaccagt tgagcaagag     5940

aaggtagaag aagccaatga aggagagaac acccgcttgt tacaccctgt gagcctgcat     6000

gggatggatg acccggagag agaagtatta gagtggaggt ttgacagccg cctagcattt     6060

catcacatgg cccgagagct gcatccggac tgtactgggt ctctctggtt agaccagatc     6120

tgagcctggg agctctctgg ctaactaggg aacccactgc ttaagcctca ataaagcttg     6180

ccttgagtgc ttcaagtagt gtgtgcccgt ctgttgtgtg actctggtaa ctagagatcc     6240

ctcagaccct tttagtcagt gtggaaaatc tctagcaggg cccgtttaaa cccgctgatc     6300

agcctcgact gtgccttcta gttgccagcc atctgttgtt tgcccctccc ccgtgccttc     6360

cttgaccctg gaaggtgcca ctcccactgt cctttcctaa taaaatgagg aaattgcatc     6420

gcattgtctg agtaggtgtc attctattct ggggggtggg gtggggcagg acagcaaggg     6480

ggaggattgg gaagacaata gcaggcatgc tggggatgcg gtgggctcta tggcttctga     6540

ggcggaaaga accagctggg gctctagggg gtatccccac gcgccctgta gcggcgcatt     6600

aagcgcggcg ggtgtggtgg ttacgcgcag cgtgaccgct acacttgcca gcgccctagc     6660

gcccgctcct ttcgctttct tcccttcctt tctcgccacg ttcgccggct ttccccgtca     6720

agctctaaat cgggggctcc ctttagggtt ccgatttagt gctttacggc acctcgaccc     6780

caaaaaactt gattagggtg atggttcacg tagtgggcca tcgccctgat agacggtttt     6840

tcgccctttg acgttggagt ccacgttctt taatagtgga ctcttgttcc aaactggaac     6900

aacactcaac cctatctcgg tctattcttt tgatttataa gggattttgc cgatttcggc     6960

ctattggtta aaaaatgagc tgatttaaca aaaatttaac gcgaattaat tctgtggaat     7020

gtgtgtcagt tagggtgtgg aaagtcccca ggctccccag caggcagaag tatgcaaagc     7080

atgcatctca attagtcagc aaccaggtgt ggaaagtccc caggctcccc agcaggcaga     7140

agtatgcaaa gcatgcatct caattagtca gcaaccatag tcccgcccct aactccgccc     7200

atcccgcccc taactccgcc cagttccgcc cattctccgc cccatggctg actaattttt     7260

tttatttatg cagaggccga ggccgcctct gcctctgagc tattccagaa gtagtgagga     7320

ggcttttttg gaggcctagg cttttgcaaa aagctcccgg gagcttgtat atccattttc     7380

ggatctgatc agcacgtgtt gacaattaat catcggcata gtatatcggc atagtataat     7440

acgacaaggt gaggaactaa accatggcca agttgaccag tgccgttccg gtgctcaccg     7500

cgcgcgacgt cgccggagcg gtcgagttct ggaccgaccg gctcgggttc tcccgggact     7560

tcgtggagga cgacttcgcc ggtgtggtcc gggacgacgt gaccctgttc atcagcgcgg     7620

tccaggacca ggtggtgccg gacaacaccc tggcctgggt gtgggtgcgc ggcctggacg     7680

agctgtacgc cgagtggtcg gaggtcgtgt ccacgaactt ccgggacgcc tccgggccgg     7740

ccatgaccga gatcggcgag cagccgtggg ggcgggagtt cgccctgcgc gacccggccg     7800

gcaactgcgt gcacttcgtg gccgaggagc aggactgaca cgtgctacga gatttcgatt     7860

ccaccgccgc cttctatgaa aggttgggct tcggaatcgt tttccgggac gccggctgga     7920

tgatcctcca gcgcggggat ctcatgctgg agttcttcgc ccaccccaac ttgtttattg     7980

cagcttataa tggttacaaa taaagcaata gcatcacaaa tttcacaaat aaagcatttt     8040

tttcactgca ttctagttgt ggtttgtcca aactcatcaa tgtatcttat catgtctgta     8100

taccgtcgac ctctagctag agcttggcgt aatcatggtc atagctgttt cctgtgtgaa     8160

attgttatcc gctcacaatt ccacacaaca tacgagccgg aagcataaag tgtaaagcct     8220

ggggtgccta atgagtgagc taactcacat taattgcgtt gcgctcactg cccgctttcc     8280

agtcgggaaa cctgtcgtgc cagctgcatt aatgaatcgg ccaacgcgcg gggagaggcg     8340

gtttgcgtat tgggcgctct tccgcttcct cgctcactga ctcgctgcgc tcggtcgttc     8400

ggctgcggcg agcggtatca gctcactcaa aggcggtaat acggttatcc acagaatcag     8460

gggataacgc aggaaagaac atgtgagcaa aaggccagca aaaggccagg aaccgtaaaa     8520

aggccgcgtt gctggcgttt ttccataggc tccgcccccc tgacgagcat cacaaaaatc     8580

gacgctcaag tcagaggtgg cgaaacccga caggactata aagataccag gcgtttcccc     8640

ctggaagctc cctcgtgcgc tctcctgttc cgaccctgcc gcttaccgga tacctgtccg     8700

cctttctccc ttcgggaagc gtggcgcttt ctcatagctc acgctgtagg tatctcagtt     8760

cggtgtaggt cgttcgctcc aagctgggct gtgtgcacga accccccgtt cagcccgacc     8820

gctgcgcctt atccggtaac tatcgtcttg agtccaaccc ggtaagacac gacttatcgc     8880

cactggcagc agccactggt aacaggatta gcagagcgag gtatgtaggc ggtgctacag     8940

agttcttgaa gtggtggcct aactacggct acactagaag aacagtattt ggtatctgcg     9000

ctctgctgaa gccagttacc ttcggaaaaa gagttggtag ctcttgatcc ggcaaacaaa     9060

ccaccgctgg tagcggtggt ttttttgttt gcaagcagca gattacgcgc agaaaaaaag     9120

gatctcaaga agatcctttg atcttttcta cggggtctga cgctcagtgg aacgaaaact     9180

cacgttaagg gattttggtc atgagattat caaaaaggat cttcacctag atccttttaa     9240

attaaaaatg aagttttaaa tcaatctaaa gtatatatga gtaaacttgg tctgacagtt     9300

accaatgctt aatcagtgag gcacctatct cagcgatctg tctatttcgt tcatccatag     9360

ttgcctgact ccccgtcgtg tagataacta cgatacggga gggcttacca tctggcccca     9420

gtgctgcaat gataccgcga gacccacgct caccggctcc agatttatca gcaataaacc     9480

agccagccgg aagggccgag cgcagaagtg gtcctgcaac tttatccgcc tccatccagt     9540

ctattaattg ttgccgggaa gctagagtaa gtagttcgcc agttaatagt ttgcgcaacg     9600

ttgttgccat tgctacaggc atcgtggtgt cacgctcgtc gtttggtatg gcttcattca     9660

gctccggttc ccaacgatca aggcgagtta catgatcccc catgttgtgc aaaaaagcgg     9720

ttagctcctt cggtcctccg atcgttgtca gaagtaagtt ggccgcagtg ttatcactca     9780

tggttatggc agcactgcat aattctctta ctgtcatgcc atccgtaaga tgcttttctg     9840

tgactggtga gtactcaacc aagtcattct gagaatagtg tatgcggcga ccgagttgct     9900

cttgcccggc gtcaatacgg gataataccg cgccacatag cagaacttta aaagtgctca     9960

tcattggaaa acgttcttcg gggcgaaaac tctcaaggat cttaccgctg ttgagatcca    10020

gttcgatgta acccactcgt gcacccaact gatcttcagc atcttttact ttcaccagcg    10080

tttctgggtg agcaaaaaca ggaaggcaaa atgccgcaaa aaagggaata agggcgacac    10140

ggaaatgttg aatactcata ctcttccttt ttcaatatta ttgaagcatt tatcagggtt    10200

attgtctcat gagcggatac atatttgaat gtatttagaa aaataaacaa ataggggttc    10260

cgcgcacatt tccccgaaaa gtgccacctg ac                                  10292


<210>  702
<211>  10253
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Synthetic nucleotide

<400>  702
gtcgacggat cgggagatct cccgatcccc tatggtgcac tctcagtaca atctgctctg       60

atgccgcata gttaagccag tatctgctcc ctgcttgtgt gttggaggtc gctgagtagt      120

gcgcgagcaa aatttaagct acaacaaggc aaggcttgac cgacaattgc atgaagaatc      180

tgcttagggt taggcgtttt gcgctgcttc gcgatgtacg ggccagatat acgcgttgac      240

attgattatt gactagttat taatagtaat caattacggg gtcattagtt catagcccat      300

atatggagtt ccgcgttaca taacttacgg taaatggccc gcctggctga ccgcccaacg      360

acccccgccc attgacgtca ataatgacgt atgttcccat agtaacgcca atagggactt      420

tccattgacg tcaatgggtg gagtatttac ggtaaactgc ccacttggca gtacatcaag      480

tgtatcatat gccaagtacg ccccctattg acgtcaatga cggtaaatgg cccgcctggc      540

attatgccca gtacatgacc ttatgggact ttcctacttg gcagtacatc tacgtattag      600

tcatcgctat taccatggtg atgcggtttt ggcagtacat caatgggcgt ggatagcggt      660

ttgactcacg gggatttcca agtctccacc ccattgacgt caatgggagt ttgttttggc      720

accaaaatca acgggacttt ccaaaatgtc gtaacaactc cgccccattg acgcaaatgg      780

gcggtaggcg tgtacggtgg gaggtctata taagcagcgc gttttgcctg tactgggtct      840

ctctggttag accagatctg agcctgggag ctctctggct aactagggaa cccactgctt      900

aagcctcaat aaagcttgcc ttgagtgctt caagtagtgt gtgcccgtct gttgtgtgac      960

tctggtaact agagatccct cagacccttt tagtcagtgt ggaaaatctc tagcagtggc     1020

gcccgaacag ggacttgaaa gcgaaaggga aaccagagga gctctctcga cgcaggactc     1080

ggcttgctga agcgcgcacg gcaagaggcg aggggcggcg actggtgagt acgccaaaaa     1140

ttttgactag cggaggctag aaggagagag atgggtgcga gagcgtcagt attaagcggg     1200

ggagaattag atcgcgatgg gaaaaaattc ggttaaggcc agggggaaag aaaaaatata     1260

aattaaaaca tatagtatgg gcaagcaggg agctagaacg attcgcagtt aatcctggcc     1320

tgttagaaac atcagaaggc tgtagacaaa tactgggaca gctacaacca tcccttcaga     1380

caggatcaga agaacttaga tcattatata atacagtagc aaccctctat tgtgtgcatc     1440

aaaggataga gataaaagac accaaggaag ctttagacaa gatagaggaa gagcaaaaca     1500

aaagtaagac caccgcacag caagcggccg ctgatcttca gacctggagg aggagatatg     1560

agggacaatt ggagaagtga attatataaa tataaagtag taaaaattga accattagga     1620

gtagcaccca ccaaggcaaa gagaagagtg gtgcagagag aaaaaagagc agtgggaata     1680

ggagctttgt tccttgggtt cttgggagca gcaggaagca ctatgggcgc agcgtcaatg     1740

acgctgacgg tacaggccag acaattattg tctggtatag tgcagcagca gaacaatttg     1800

ctgagggcta ttgaggcgca acagcatctg ttgcaactca cagtctgggg catcaagcag     1860

ctccaggcaa gaatcctggc tgtggaaaga tacctaaagg atcaacagct cctggggatt     1920

tggggttgct ctggaaaact catttgcacc actgctgtgc cttggaatgc tagttggagt     1980

aataaatctc tggaacagat ttggaatcac acgacctgga tggagtggga cagagaaatt     2040

aacaattaca caagcttaat acactcctta attgaagaat cgcaaaacca gcaagaaaag     2100

aatgaacaag aattattgga attagataaa tgggcaagtt tgtggaattg gtttaacata     2160

acaaattggc tgtggtatat aaaattattc ataatgatag taggaggctt ggtaggttta     2220

agaatagttt ttgctgtact ttctatagtg aatagagtta ggcagggata ttcaccatta     2280

tcgtttcaga cccacctccc aaccccgagg ggacccgaca ggcccgaagg aatagaagaa     2340

gaaggtggag agagagacag agacagatcc attcgattag tgaacggatc ggcactgcgt     2400

gcgccaattc tgcagacaaa tggcagtatt catccacaat tttaaaagaa aaggggggat     2460

tggggggtac agtgcagggg aaagaatagt agacataata gcaacagaca tacaaactaa     2520

agaattacaa aaacaaatta caaaaattca aaattttcgg gtttattaca gggacagcag     2580

agatccagtt tggttaatta gctagctagg tcttgaaagg agtgggaatt ggctccggtg     2640

cccgtcagtg ggcagagcgc acatcgccca cagtccccga gaagttgggg ggaggggtcg     2700

gcaattgatc cggtgcctag agaaggtggc gcggggtaaa ctgggaaagt gatgtcgtgt     2760

actggctccg cctttttccc gagggtgggg gagaaccgta tataagtgca gtagtcgccg     2820

tgaacgttct ttttcgcaac gggtttgccg ccagaacaca ggaccggttc tagagcgctt     2880

taattaagcc accatggact ggacctggat tctgtttctg gtggccgccg ctacaagagt     2940

gcacagcttc ctggattctc cagaccggcc ttggaacccc cccaccttct ccccagccct     3000

gctggtggtg acagagggcg acaacgccac cttcacatgc agcttttcta ataccagcga     3060

gagcttcgtg ctgaattggt acagaatgtc ccctagcaac cagaccgaca agctggccgc     3120

ttttcctgag gacagatctc agcctggaca ggattgcaga ttcagagtga cccagctgcc     3180

taacggcaga gacttccaca tgagcgtggt cagagccaga cggaacgaca gcggaacata     3240

tctgtgcggc gccatcagcc tggcccctaa ggcccaaatc aaggaaagcc tgagagctga     3300

actgagggtt accgagcggc gggccgaagt gcccacagcc cactgcccta gccctctgtt     3360

ccccggcccc agcaaacctt tctgggtcct ggtggtggtg ggcggcgtgc tggcttgtta     3420

cagcctcctg gtgaccgtgg ccttcatcat cttctgggtg cggagcaagc ggagtagact     3480

gctgcattct gattacatga acatgacccc tagacggcct ggccctacca gaaagcacta     3540

ccagccctac gcccctccaa gagatttcgc cgcctaccgc tcctgagaat tccgcccccc     3600

cccccccccc ccctctccct cccccccccc taacgttact ggccgaagcc gcttggaata     3660

aggccggtgt gcgtttgtct atatgttatt ttccaccata ttgccgtctt ttggcaatgt     3720

gagggcccgg aaacctggcc ctgtcttctt gacgagcatt cctaggggtc tttcccctct     3780

cgccaaagga atgcaaggtc tgttgaatgt cgtgaaggaa gcagttcctc tggaagcttc     3840

ttgaagacaa acaacgtctg tagcgaccct ttgcaggcag cggaaccccc cacctggcga     3900

caggtgcctc tgcggccaaa agccacgtgt ataagataca cctgcaaagg cggcacaacc     3960

ccagtgccac gttgtgagtt ggatagttgt ggaaagagtc aaatggctct cctcaagcgt     4020

attcaacaag gggctgaagg atgcccagaa ggtaccccat tgtatgggat ctgatctggg     4080

gcctcggtgc acatgcttta catgtgttta gtcgaggtta aaaaaacgtc taggcccccc     4140

gaaccacggg gacgtggttt tcctttgaaa aacacgatga taagcttgat cacgcgtgcc     4200

accatgagca agggcgagga gctgttcacc ggggtggtgc ccatcctggt cgagctggac     4260

ggcgacgtaa acggccacaa gttcagcgtg tccggcgagg gcgagggcga tgccacctac     4320

ggcaagctga ccctgaagtt catctgcacc accggcaagc tgcccgtgcc ctggcccacc     4380

ctcgtgacca ccctgaccta cggcgtgcag tgcttcagcc gctaccccga ccacatgaag     4440

cagcacgact tcttcaagtc cgccatgccc gaaggctacg tccaggagcg caccatcttc     4500

ttcaaggacg acggcaacta caagacccgc gccgaggtga agttcgaggg cgacaccctg     4560

gtgaaccgca tcgagctgaa gggcatcgac ttcaaggagg acggcaacat cctggggcac     4620

aagctggagt acaactacaa cagccacaac gtctatatca tggccgacaa gcagaagaac     4680

ggcatcaagg tgaacttcaa gatccgccac aacatcgagg acggcagcgt gcagctcgcc     4740

gaccactacc agcagaacac ccccatcggc gacggccccg tgctgctgcc cgacaaccac     4800

tacctgagca cccagtccgc cctgagcaaa gaccccaacg agaagcgcga tcacatggtc     4860

ctgctggagt tcgtgaccgc cgccgggatc actcacggca tggacgagct gtacaagtga     4920

gaattcgata tcaagcttat cggtaatcaa cctctggatt acaaaatttg tgaaagattg     4980

actggtattc ttaactatgt tgctcctttt acgctatgtg gatacgctgc tttaatgcct     5040

ttgtatcatg ctattgcttc ccgtatggct ttcattttct cctccttgta taaatcctgg     5100

ttgctgtctc tttatgagga gttgtggccc gttgtcaggc aacgtggcgt ggtgtgcact     5160

gtgtttgctg acgcaacccc cactggttgg ggcattgcca ccacctgtca gctcctttcc     5220

gggactttcg ctttccccct ccctattgcc acggcggaac tcatcgccgc ctgccttgcc     5280

cgctgctgga caggggctcg gctgttgggc actgacaatt ccgtggtgtt gtcggggaaa     5340

tcatcgtcct ttccttggct gctcgcctgt gttgccacct ggattctgcg cgggacgtcc     5400

ttctgctacg tcccttcggc cctcaatcca gcggaccttc cttcccgcgg cctgctgccg     5460

gctctgcggc ctcttccgcg tcttcgcctt cgccctcaga cgagtcggat ctccctttgg     5520

gccgcctccc cgcatcgata ccgtcgacct cgagacctag aaaaacatgg agcaatcaca     5580

agtagcaata cagcagctac caatgctgat tgtgcctggc tagaagcaca agaggaggag     5640

gaggtgggtt ttccagtcac acctcaggta cctttaagac caatgactta caaggcagct     5700

gtagatctta gccacttttt aaaagaaaag gggggactgg aagggctaat tcactcccaa     5760

cgaagacaag atatccttga tctgtggatc taccacacac aaggctactt ccctgattgg     5820

cagaactaca caccagggcc agggatcaga tatccactga cctttggatg gtgctacaag     5880

ctagtaccag ttgagcaaga gaaggtagaa gaagccaatg aaggagagaa cacccgcttg     5940

ttacaccctg tgagcctgca tgggatggat gacccggaga gagaagtatt agagtggagg     6000

tttgacagcc gcctagcatt tcatcacatg gcccgagagc tgcatccgga ctgtactggg     6060

tctctctggt tagaccagat ctgagcctgg gagctctctg gctaactagg gaacccactg     6120

cttaagcctc aataaagctt gccttgagtg cttcaagtag tgtgtgcccg tctgttgtgt     6180

gactctggta actagagatc cctcagaccc ttttagtcag tgtggaaaat ctctagcagg     6240

gcccgtttaa acccgctgat cagcctcgac tgtgccttct agttgccagc catctgttgt     6300

ttgcccctcc cccgtgcctt ccttgaccct ggaaggtgcc actcccactg tcctttccta     6360

ataaaatgag gaaattgcat cgcattgtct gagtaggtgt cattctattc tggggggtgg     6420

ggtggggcag gacagcaagg gggaggattg ggaagacaat agcaggcatg ctggggatgc     6480

ggtgggctct atggcttctg aggcggaaag aaccagctgg ggctctaggg ggtatcccca     6540

cgcgccctgt agcggcgcat taagcgcggc gggtgtggtg gttacgcgca gcgtgaccgc     6600

tacacttgcc agcgccctag cgcccgctcc tttcgctttc ttcccttcct ttctcgccac     6660

gttcgccggc tttccccgtc aagctctaaa tcgggggctc cctttagggt tccgatttag     6720

tgctttacgg cacctcgacc ccaaaaaact tgattagggt gatggttcac gtagtgggcc     6780

atcgccctga tagacggttt ttcgcccttt gacgttggag tccacgttct ttaatagtgg     6840

actcttgttc caaactggaa caacactcaa ccctatctcg gtctattctt ttgatttata     6900

agggattttg ccgatttcgg cctattggtt aaaaaatgag ctgatttaac aaaaatttaa     6960

cgcgaattaa ttctgtggaa tgtgtgtcag ttagggtgtg gaaagtcccc aggctcccca     7020

gcaggcagaa gtatgcaaag catgcatctc aattagtcag caaccaggtg tggaaagtcc     7080

ccaggctccc cagcaggcag aagtatgcaa agcatgcatc tcaattagtc agcaaccata     7140

gtcccgcccc taactccgcc catcccgccc ctaactccgc ccagttccgc ccattctccg     7200

ccccatggct gactaatttt ttttatttat gcagaggccg aggccgcctc tgcctctgag     7260

ctattccaga agtagtgagg aggctttttt ggaggcctag gcttttgcaa aaagctcccg     7320

ggagcttgta tatccatttt cggatctgat cagcacgtgt tgacaattaa tcatcggcat     7380

agtatatcgg catagtataa tacgacaagg tgaggaacta aaccatggcc aagttgacca     7440

gtgccgttcc ggtgctcacc gcgcgcgacg tcgccggagc ggtcgagttc tggaccgacc     7500

ggctcgggtt ctcccgggac ttcgtggagg acgacttcgc cggtgtggtc cgggacgacg     7560

tgaccctgtt catcagcgcg gtccaggacc aggtggtgcc ggacaacacc ctggcctggg     7620

tgtgggtgcg cggcctggac gagctgtacg ccgagtggtc ggaggtcgtg tccacgaact     7680

tccgggacgc ctccgggccg gccatgaccg agatcggcga gcagccgtgg gggcgggagt     7740

tcgccctgcg cgacccggcc ggcaactgcg tgcacttcgt ggccgaggag caggactgac     7800

acgtgctacg agatttcgat tccaccgccg ccttctatga aaggttgggc ttcggaatcg     7860

ttttccggga cgccggctgg atgatcctcc agcgcgggga tctcatgctg gagttcttcg     7920

cccaccccaa cttgtttatt gcagcttata atggttacaa ataaagcaat agcatcacaa     7980

atttcacaaa taaagcattt ttttcactgc attctagttg tggtttgtcc aaactcatca     8040

atgtatctta tcatgtctgt ataccgtcga cctctagcta gagcttggcg taatcatggt     8100

catagctgtt tcctgtgtga aattgttatc cgctcacaat tccacacaac atacgagccg     8160

gaagcataaa gtgtaaagcc tggggtgcct aatgagtgag ctaactcaca ttaattgcgt     8220

tgcgctcact gcccgctttc cagtcgggaa acctgtcgtg ccagctgcat taatgaatcg     8280

gccaacgcgc ggggagaggc ggtttgcgta ttgggcgctc ttccgcttcc tcgctcactg     8340

actcgctgcg ctcggtcgtt cggctgcggc gagcggtatc agctcactca aaggcggtaa     8400

tacggttatc cacagaatca ggggataacg caggaaagaa catgtgagca aaaggccagc     8460

aaaaggccag gaaccgtaaa aaggccgcgt tgctggcgtt tttccatagg ctccgccccc     8520

ctgacgagca tcacaaaaat cgacgctcaa gtcagaggtg gcgaaacccg acaggactat     8580

aaagatacca ggcgtttccc cctggaagct ccctcgtgcg ctctcctgtt ccgaccctgc     8640

cgcttaccgg atacctgtcc gcctttctcc cttcgggaag cgtggcgctt tctcatagct     8700

cacgctgtag gtatctcagt tcggtgtagg tcgttcgctc caagctgggc tgtgtgcacg     8760

aaccccccgt tcagcccgac cgctgcgcct tatccggtaa ctatcgtctt gagtccaacc     8820

cggtaagaca cgacttatcg ccactggcag cagccactgg taacaggatt agcagagcga     8880

ggtatgtagg cggtgctaca gagttcttga agtggtggcc taactacggc tacactagaa     8940

gaacagtatt tggtatctgc gctctgctga agccagttac cttcggaaaa agagttggta     9000

gctcttgatc cggcaaacaa accaccgctg gtagcggtgg tttttttgtt tgcaagcagc     9060

agattacgcg cagaaaaaaa ggatctcaag aagatccttt gatcttttct acggggtctg     9120

acgctcagtg gaacgaaaac tcacgttaag ggattttggt catgagatta tcaaaaagga     9180

tcttcaccta gatcctttta aattaaaaat gaagttttaa atcaatctaa agtatatatg     9240

agtaaacttg gtctgacagt taccaatgct taatcagtga ggcacctatc tcagcgatct     9300

gtctatttcg ttcatccata gttgcctgac tccccgtcgt gtagataact acgatacggg     9360

agggcttacc atctggcccc agtgctgcaa tgataccgcg agacccacgc tcaccggctc     9420

cagatttatc agcaataaac cagccagccg gaagggccga gcgcagaagt ggtcctgcaa     9480

ctttatccgc ctccatccag tctattaatt gttgccggga agctagagta agtagttcgc     9540

cagttaatag tttgcgcaac gttgttgcca ttgctacagg catcgtggtg tcacgctcgt     9600

cgtttggtat ggcttcattc agctccggtt cccaacgatc aaggcgagtt acatgatccc     9660

ccatgttgtg caaaaaagcg gttagctcct tcggtcctcc gatcgttgtc agaagtaagt     9720

tggccgcagt gttatcactc atggttatgg cagcactgca taattctctt actgtcatgc     9780

catccgtaag atgcttttct gtgactggtg agtactcaac caagtcattc tgagaatagt     9840

gtatgcggcg accgagttgc tcttgcccgg cgtcaatacg ggataatacc gcgccacata     9900

gcagaacttt aaaagtgctc atcattggaa aacgttcttc ggggcgaaaa ctctcaagga     9960

tcttaccgct gttgagatcc agttcgatgt aacccactcg tgcacccaac tgatcttcag    10020

catcttttac tttcaccagc gtttctgggt gagcaaaaac aggaaggcaa aatgccgcaa    10080

aaaagggaat aagggcgaca cggaaatgtt gaatactcat actcttcctt tttcaatatt    10140

attgaagcat ttatcagggt tattgtctca tgagcggata catatttgaa tgtatttaga    10200

aaaataaaca aataggggtt ccgcgcacat ttccccgaaa agtgccacct gac           10253


<210>  703
<211>  386
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic amino acid

<400>  703

Met Asp Trp Thr Trp Ile Leu Phe Leu Val Ala Ala Ala Thr Arg Val 
1               5                   10                  15      


His Ser Gln Val Thr Asp Ile Asn Ser Lys Gly Leu Glu Leu Arg Lys 
            20                  25                  30          


Thr Val Thr Thr Val Glu Thr Gln Asn Leu Glu Gly Leu His His Asp 
        35                  40                  45              


Gly Gln Phe Cys His Lys Pro Cys Pro Pro Gly Glu Arg Lys Ala Arg 
    50                  55                  60                  


Asp Cys Thr Val Asn Gly Asp Glu Pro Asp Cys Val Pro Cys Gln Glu 
65                  70                  75                  80  


Gly Lys Glu Tyr Thr Asp Lys Ala His Phe Ser Ser Lys Cys Arg Arg 
                85                  90                  95      


Cys Arg Leu Cys Asp Glu Gly His Gly Leu Glu Val Glu Ile Asn Cys 
            100                 105                 110         


Thr Arg Thr Gln Asn Thr Lys Cys Arg Cys Lys Pro Asn Phe Phe Cys 
        115                 120                 125             


Asn Ser Thr Val Cys Glu His Cys Asp Pro Cys Thr Lys Cys Glu His 
    130                 135                 140                 


Gly Ile Ile Lys Glu Cys Thr Leu Thr Ser Asn Thr Lys Cys Lys Glu 
145                 150                 155                 160 


Glu Gly Ser Arg Ser Asn Pro Leu Pro Pro Glu Met Ser Gly Thr Met 
                165                 170                 175     


Leu Met Leu Ala Val Leu Leu Pro Leu Ala Phe Phe Leu Leu Leu Ala 
            180                 185                 190         


Thr Val Phe Ser Cys Ile Trp Lys Ser His Pro Ser Leu Cys Arg Lys 
        195                 200                 205             


Leu Gly Ser Leu Leu Lys Arg Arg Pro Gln Gly Glu Gly Pro Asn Pro 
    210                 215                 220                 


Val Ala Gly Ser Trp Glu Pro Pro Lys Ala His Pro Tyr Phe Pro Asp 
225                 230                 235                 240 


Leu Val Gln Pro Leu Leu Pro Ile Ser Gly Asp Val Ser Pro Val Ser 
                245                 250                 255     


Thr Gly Leu Pro Ala Ala Pro Val Leu Glu Ala Gly Val Pro Gln Gln 
            260                 265                 270         


Gln Ser Pro Leu Asp Leu Thr Arg Glu Pro Gln Leu Glu Pro Gly Glu 
        275                 280                 285             


Gln Ser Gln Val Ala His Gly Thr Asn Gly Ile His Val Thr Gly Gly 
    290                 295                 300                 


Ser Met Thr Ile Thr Gly Asn Ile Tyr Ile Tyr Asn Gly Pro Val Leu 
305                 310                 315                 320 


Gly Gly Pro Pro Gly Pro Gly Asp Leu Pro Ala Thr Pro Glu Pro Pro 
                325                 330                 335     


Tyr Pro Ile Pro Glu Glu Gly Asp Pro Gly Pro Pro Gly Leu Ser Thr 
            340                 345                 350         


Pro His Gln Glu Asp Gly Lys Ala Trp His Leu Ala Glu Thr Glu His 
        355                 360                 365             


Cys Gly Ala Thr Pro Ser Asn Arg Gly Pro Arg Asn Gln Phe Ile Thr 
    370                 375                 380                 


His Asp 
385     


<210>  704
<211>  370
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic amino acid

<400>  704

Met Asp Trp Thr Trp Ile Leu Phe Leu Val Ala Ala Ala Thr Arg Val 
1               5                   10                  15      


His Ser Phe Leu Asp Ser Pro Asp Arg Pro Trp Asn Pro Pro Thr Phe 
            20                  25                  30          


Ser Pro Ala Leu Leu Val Val Thr Glu Gly Asp Asn Ala Thr Phe Thr 
        35                  40                  45              


Cys Ser Phe Ser Asn Thr Ser Glu Ser Phe Val Leu Asn Trp Tyr Arg 
    50                  55                  60                  


Met Ser Pro Ser Asn Gln Thr Asp Lys Leu Ala Ala Phe Pro Glu Asp 
65                  70                  75                  80  


Arg Ser Gln Pro Gly Gln Asp Cys Arg Phe Arg Val Thr Gln Leu Pro 
                85                  90                  95      


Asn Gly Arg Asp Phe His Met Ser Val Val Arg Ala Arg Arg Asn Asp 
            100                 105                 110         


Ser Gly Thr Tyr Leu Cys Gly Ala Ile Ser Leu Ala Pro Lys Ala Gln 
        115                 120                 125             


Ile Lys Glu Ser Leu Arg Ala Glu Leu Arg Val Thr Glu Arg Arg Ala 
    130                 135                 140                 


Glu Val Pro Thr Ala His Pro Leu Pro Pro Glu Met Ser Gly Thr Met 
145                 150                 155                 160 


Leu Met Leu Ala Val Leu Leu Pro Leu Ala Phe Phe Leu Leu Leu Ala 
                165                 170                 175     


Thr Val Phe Ser Cys Ile Trp Lys Ser His Pro Ser Leu Cys Arg Lys 
            180                 185                 190         


Leu Gly Ser Leu Leu Lys Arg Arg Pro Gln Gly Glu Gly Pro Asn Pro 
        195                 200                 205             


Val Ala Gly Ser Trp Glu Pro Pro Lys Ala His Pro Tyr Phe Pro Asp 
    210                 215                 220                 


Leu Val Gln Pro Leu Leu Pro Ile Ser Gly Asp Val Ser Pro Val Ser 
225                 230                 235                 240 


Thr Gly Leu Pro Ala Ala Pro Val Leu Glu Ala Gly Val Pro Gln Gln 
                245                 250                 255     


Gln Ser Pro Leu Asp Leu Thr Arg Glu Pro Gln Leu Glu Pro Gly Glu 
            260                 265                 270         


Gln Ser Gln Val Ala His Gly Thr Asn Gly Ile His Val Thr Gly Gly 
        275                 280                 285             


Ser Met Thr Ile Thr Gly Asn Ile Tyr Ile Tyr Asn Gly Pro Val Leu 
    290                 295                 300                 


Gly Gly Pro Pro Gly Pro Gly Asp Leu Pro Ala Thr Pro Glu Pro Pro 
305                 310                 315                 320 


Tyr Pro Ile Pro Glu Glu Gly Asp Pro Gly Pro Pro Gly Leu Ser Thr 
                325                 330                 335     


Pro His Gln Glu Asp Gly Lys Ala Trp His Leu Ala Glu Thr Glu His 
            340                 345                 350         


Cys Gly Ala Thr Pro Ser Asn Arg Gly Pro Arg Asn Gln Phe Ile Thr 
        355                 360                 365             


His Asp 
    370 


<210>  705
<211>  382
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic amino acid

<400>  705

Met Asp Trp Thr Trp Ile Leu Phe Leu Val Ala Ala Ala Thr Arg Val 
1               5                   10                  15      


His Ser Thr Ile Pro Pro His Val Gln Lys Ser Val Asn Asn Asp Met 
            20                  25                  30          


Ile Val Thr Asp Asn Asn Gly Ala Val Lys Phe Pro Gln Leu Cys Lys 
        35                  40                  45              


Phe Cys Asp Val Arg Phe Ser Thr Cys Asp Asn Gln Lys Ser Cys Met 
    50                  55                  60                  


Ser Asn Cys Ser Ile Thr Ser Ile Cys Glu Lys Pro Gln Glu Val Cys 
65                  70                  75                  80  


Val Ala Val Trp Arg Lys Asn Asp Glu Asn Ile Thr Leu Glu Thr Val 
                85                  90                  95      


Cys His Asp Pro Lys Leu Pro Tyr His Asp Phe Ile Leu Glu Asp Ala 
            100                 105                 110         


Ala Ser Pro Lys Cys Ile Met Lys Glu Lys Lys Lys Pro Gly Glu Thr 
        115                 120                 125             


Phe Phe Met Cys Ser Cys Ser Ser Asp Glu Cys Asn Asp Asn Ile Ile 
    130                 135                 140                 


Phe Ser Glu Glu Tyr Asn Thr Ser Asn Pro Asp Leu Leu Leu Val Ile 
145                 150                 155                 160 


Phe Gln Pro Leu Pro Pro Glu Met Ser Gly Thr Met Leu Met Leu Ala 
                165                 170                 175     


Val Leu Leu Pro Leu Ala Phe Phe Leu Leu Leu Ala Thr Val Phe Ser 
            180                 185                 190         


Cys Ile Trp Lys Ser His Pro Ser Leu Cys Arg Lys Leu Gly Ser Leu 
        195                 200                 205             


Leu Lys Arg Arg Pro Gln Gly Glu Gly Pro Asn Pro Val Ala Gly Ser 
    210                 215                 220                 


Trp Glu Pro Pro Lys Ala His Pro Tyr Phe Pro Asp Leu Val Gln Pro 
225                 230                 235                 240 


Leu Leu Pro Ile Ser Gly Asp Val Ser Pro Val Ser Thr Gly Leu Pro 
                245                 250                 255     


Ala Ala Pro Val Leu Glu Ala Gly Val Pro Gln Gln Gln Ser Pro Leu 
            260                 265                 270         


Asp Leu Thr Arg Glu Pro Gln Leu Glu Pro Gly Glu Gln Ser Gln Val 
        275                 280                 285             


Ala His Gly Thr Asn Gly Ile His Val Thr Gly Gly Ser Met Thr Ile 
    290                 295                 300                 


Thr Gly Asn Ile Tyr Ile Tyr Asn Gly Pro Val Leu Gly Gly Pro Pro 
305                 310                 315                 320 


Gly Pro Gly Asp Leu Pro Ala Thr Pro Glu Pro Pro Tyr Pro Ile Pro 
                325                 330                 335     


Glu Glu Gly Asp Pro Gly Pro Pro Gly Leu Ser Thr Pro His Gln Glu 
            340                 345                 350         


Asp Gly Lys Ala Trp His Leu Ala Glu Thr Glu His Cys Gly Ala Thr 
        355                 360                 365             


Pro Ser Asn Arg Gly Pro Arg Asn Gln Phe Ile Thr His Asp 
    370                 375                 380         


<210>  706
<211>  1158
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Synthetic nucleotide

<400>  706
atggattgga cctggatcct gttcctggtg gctgcggcta cacgggtcca ctcacaggtc       60

accgacatta actcgaaggg cctggagctg cgcaagactg tgacgaccgt ggagacccag      120

aacctggaag gtttgcacca cgatggacag ttttgtcaca agccctgccc gcctggtgag      180

cggaaggccc gcgactgtac cgtcaacgga gacgagcccg actgcgtgcc ttgccaggag      240

ggcaaagagt acaccgacaa ggcccacttt agctccaaat gccgtaggtg tcgcctgtgc      300

gacgagggcc acgggctgga ggtggagatc aactgcactc gcacccagaa cacgaaatgc      360

agatgtaagc ctaacttttt ctgtaattcc accgtttgcg agcactgtga tccatgcacc      420

aagtgcgagc acggtatcat caaggagtgc actctgacct ccaatacgaa gtgcaaggag      480

gagggttccc gcagcaatcc actgcccccc gagatgtctg gcaccatgct gatgctcgcg      540

gtgctgctcc ctctagcgtt cttcctgctg cttgccaccg tattcagctg tatttggaag      600

agccacccct cactgtgccg taagctcggc tctctgctga agcgccgacc tcagggagag      660

ggacccaacc ctgtggctgg gagttgggag ccgcccaagg cccatcccta tttcccggat      720

cttgtgcagc cattactccc catctctggt gacgtgtccc cagtgtcgac cggccttccg      780

gccgctccgg ttctagaagc aggcgtgccc caacagcagt cccccttgga cctgactcgt      840

gagccgcagc tggagcccgg ggaacagtcc caggtggcgc atggcaccaa cggcatccat      900

gtcacaggcg gctccatgac catcaccggg aacatctaca tatacaacgg tccggtgctg      960

ggtgggcctc ccggccctgg ggaccttccc gcaactccgg aaccacccta cccaatccct     1020

gaggagggtg acccgggacc cccgggcctc tctacccccc accaggagga cggcaaagcc     1080

tggcacttgg ccgagaccga gcactgtggc gctactccta gcaaccgcgg cccgcgcaac     1140

cagttcatta ctcatgac                                                   1158


<210>  707
<211>  1110
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Synthetic nucleotide

<400>  707
atggattgga cctggatcct gtttctggtg gctgctgcca cgagagtgca ctcttttctc       60

gattcccccg accgcccgtg gaacccgccc acgttctcac cggcgctgct agtagtcacc      120

gagggcgaca acgccacctt cacctgctcg ttttcgaaca cgtccgagtc cttcgtcctc      180

aactggtaca ggatgagccc atccaaccag actgacaaac tggcagcgtt cccggaagac      240

cgctcccagc ctggccagga ctgccgattc cgcgttaccc agcttcccaa tggccgcgac      300

tttcacatgt ccgtggtccg ggctcgtcgc aacgactccg gtacctacct gtgcggcgcc      360

atctctttgg cacctaaggc ccaaattaaa gagagcctgc gcgccgagct tcgggtgaca      420

gagcgccgtg cggaggtgcc cactgctcac cctttgccac ccgagatgtc aggcacaatg      480

ctgatgctgg ctgtgctgct gccactggcg ttcttcctgc ttctagccac cgtgttcagc      540

tgtatttgga agagtcaccc ctctctgtgc cgcaagctgg gctctctact gaagcgcagg      600

cctcagggcg agggccctaa tccagttgcc ggcagttggg agccccccaa ggcacatccc      660

tatttccccg acttggtaca gccgttgctc cccatttctg gtgacgtgtc cccggtgtcc      720

accggtctcc ccgctgcccc agtcctggag gctggggtgc ctcagcagca gagccccctg      780

gacctgaccc gtgaacctca gctggagcca ggagaacaga gccaggtggc gcatggaacc      840

aacggcatcc acgtcactgg agggtccatg accatcaccg gcaacatcta catctacaac      900

gggccagtgc tgggaggtcc cccaggccct ggcgatctgc cggctacccc ggagcctcct      960

taccctatcc ccgaggaggg cgacccgggg ccgcccggct tatcgacccc tcaccaggag     1020

gacggcaagg cctggcacct cgccgagact gagcactgtg gggccacccc cagcaaccgc     1080

ggcccgcgca atcagttcat cactcatgac                                      1110


<210>  708
<211>  1146
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Synthetic nucleotide

<400>  708
atggattgga cctggatcct atttctggtg gcggctgcga ctcgggtgca ctcgaccatc       60

ccgccgcacg ttcagaagtc cgttaacaac gacatgatcg tgaccgacaa caatggcgcc      120

gtgaaattcc cccagctgtg caagttttgc gacgtgcgct tttcaacctg cgacaaccag      180

aagtcatgca tgagcaactg ctctattacc agcatctgcg agaagcctca ggaggtgtgc      240

gtggctgtct ggcgtaagaa cgacgagaac atcaccctgg agaccgtctg ccacgacccg      300

aagttaccct atcacgattt catactggaa gacgcagcct ccccgaagtg catcatgaag      360

gagaaaaaga agcctgggga gaccttcttc atgtgctcct gttcctcgga cgagtgtaac      420

gacaacatca tctttagcga agagtacaac acgtccaatc cagacctgct cctggtaatc      480

ttccagcctc tgccccccga gatgtctggc accatgctga tgttggccgt cctccttccg      540

cttgcgttct tcctgcttct ggccaccgtg ttcagttgta tttggaagag ccacccttct      600

ctgtgccgaa agctgggctc cttgctcaaa cgcaggcccc agggcgaggg acccaatcca      660

gtggctggca gttgggagcc gcccaaggcc catccctact tccccgacct ggtgcagcct      720

ttgttaccaa tctctggtga tgtcagcccc gtgtccacag gcctgcctgc cgcgccggtg      780

ctggaggccg gggtgcctca gcagcagtcg cccctagacc tgacccgcga gccccaactg      840

gagccaggag aacagagcca ggtcgcgcat ggaactaatg gcatccacgt caccggtggc      900

tccatgacga tcaccggcaa catttacatc tacaacggtc cggtgctggg cggccctccg      960

gggcctggtg atctgccggc cacgcctgag cccccctacc ccatcccgga ggagggagat     1020

ccagggccac ctggcctctc caccccccac caggaggacg gcaaagcttg gcacctcgca     1080

gagactgagc actgtggcgc tactccctct aaccgcggtc cccgcaacca gttcattact     1140

catgac                                                                1146


<210>  709
<211>  10673
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Synthetic nucleotide

<400>  709
gtcgacggat cgggagatct cccgatcccc tatggtgcac tctcagtaca atctgctctg       60

atgccgcata gttaagccag tatctgctcc ctgcttgtgt gttggaggtc gctgagtagt      120

gcgcgagcaa aatttaagct acaacaaggc aaggcttgac cgacaattgc atgaagaatc      180

tgcttagggt taggcgtttt gcgctgcttc gcgatgtacg ggccagatat acgcgttgac      240

attgattatt gactagttat taatagtaat caattacggg gtcattagtt catagcccat      300

atatggagtt ccgcgttaca taacttacgg taaatggccc gcctggctga ccgcccaacg      360

acccccgccc attgacgtca ataatgacgt atgttcccat agtaacgcca atagggactt      420

tccattgacg tcaatgggtg gagtatttac ggtaaactgc ccacttggca gtacatcaag      480

tgtatcatat gccaagtacg ccccctattg acgtcaatga cggtaaatgg cccgcctggc      540

attatgccca gtacatgacc ttatgggact ttcctacttg gcagtacatc tacgtattag      600

tcatcgctat taccatggtg atgcggtttt ggcagtacat caatgggcgt ggatagcggt      660

ttgactcacg gggatttcca agtctccacc ccattgacgt caatgggagt ttgttttggc      720

accaaaatca acgggacttt ccaaaatgtc gtaacaactc cgccccattg acgcaaatgg      780

gcggtaggcg tgtacggtgg gaggtctata taagcagcgc gttttgcctg tactgggtct      840

ctctggttag accagatctg agcctgggag ctctctggct aactagggaa cccactgctt      900

aagcctcaat aaagcttgcc ttgagtgctt caagtagtgt gtgcccgtct gttgtgtgac      960

tctggtaact agagatccct cagacccttt tagtcagtgt ggaaaatctc tagcagtggc     1020

gcccgaacag ggacttgaaa gcgaaaggga aaccagagga gctctctcga cgcaggactc     1080

ggcttgctga agcgcgcacg gcaagaggcg aggggcggcg actggtgagt acgccaaaaa     1140

ttttgactag cggaggctag aaggagagag atgggtgcga gagcgtcagt attaagcggg     1200

ggagaattag atcgcgatgg gaaaaaattc ggttaaggcc agggggaaag aaaaaatata     1260

aattaaaaca tatagtatgg gcaagcaggg agctagaacg attcgcagtt aatcctggcc     1320

tgttagaaac atcagaaggc tgtagacaaa tactgggaca gctacaacca tcccttcaga     1380

caggatcaga agaacttaga tcattatata atacagtagc aaccctctat tgtgtgcatc     1440

aaaggataga gataaaagac accaaggaag ctttagacaa gatagaggaa gagcaaaaca     1500

aaagtaagac caccgcacag caagcggccg ctgatcttca gacctggagg aggagatatg     1560

agggacaatt ggagaagtga attatataaa tataaagtag taaaaattga accattagga     1620

gtagcaccca ccaaggcaaa gagaagagtg gtgcagagag aaaaaagagc agtgggaata     1680

ggagctttgt tccttgggtt cttgggagca gcaggaagca ctatgggcgc agcgtcaatg     1740

acgctgacgg tacaggccag acaattattg tctggtatag tgcagcagca gaacaatttg     1800

ctgagggcta ttgaggcgca acagcatctg ttgcaactca cagtctgggg catcaagcag     1860

ctccaggcaa gaatcctggc tgtggaaaga tacctaaagg atcaacagct cctggggatt     1920

tggggttgct ctggaaaact catttgcacc actgctgtgc cttggaatgc tagttggagt     1980

aataaatctc tggaacagat ttggaatcac acgacctgga tggagtggga cagagaaatt     2040

aacaattaca caagcttaat acactcctta attgaagaat cgcaaaacca gcaagaaaag     2100

aatgaacaag aattattgga attagataaa tgggcaagtt tgtggaattg gtttaacata     2160

acaaattggc tgtggtatat aaaattattc ataatgatag taggaggctt ggtaggttta     2220

agaatagttt ttgctgtact ttctatagtg aatagagtta ggcagggata ttcaccatta     2280

tcgtttcaga cccacctccc aaccccgagg ggacccgaca ggcccgaagg aatagaagaa     2340

gaaggtggag agagagacag agacagatcc attcgattag tgaacggatc ggcactgcgt     2400

gcgccaattc tgcagacaaa tggcagtatt catccacaat tttaaaagaa aaggggggat     2460

tggggggtac agtgcagggg aaagaatagt agacataata gcaacagaca tacaaactaa     2520

agaattacaa aaacaaatta caaaaattca aaattttcgg gtttattaca gggacagcag     2580

agatccagtt tggttaatta gctagctagg tcttgaaagg agtgggaatt ggctccggtg     2640

cccgtcagtg ggcagagcgc acatcgccca cagtccccga gaagttgggg ggaggggtcg     2700

gcaattgatc cggtgcctag agaaggtggc gcggggtaaa ctgggaaagt gatgtcgtgt     2760

actggctccg cctttttccc gagggtgggg gagaaccgta tataagtgca gtagtcgccg     2820

tgaacgttct ttttcgcaac gggtttgccg ccagaacaca ggaccggttc tagagcgctt     2880

taattaagcc accatggatt ggacctggat cctgtttctg gtggctgctg ccacgagagt     2940

gcactctttt ctcgattccc ccgaccgccc gtggaacccg cccacgttct caccggcgct     3000

gctagtagtc accgagggcg acaacgccac cttcacctgc tcgttttcga acacgtccga     3060

gtccttcgtc ctcaactggt acaggatgag cccatccaac cagactgaca aactggcagc     3120

gttcccggaa gaccgctccc agcctggcca ggactgccga ttccgcgtta cccagcttcc     3180

caatggccgc gactttcaca tgtccgtggt ccgggctcgt cgcaacgact ccggtaccta     3240

cctgtgcggc gccatctctt tggcacctaa ggcccaaatt aaagagagcc tgcgcgccga     3300

gcttcgggtg acagagcgcc gtgcggaggt gcccactgct caccctttgc cacccgagat     3360

gtcaggcaca atgctgatgc tggctgtgct gctgccactg gcgttcttcc tgcttctagc     3420

caccgtgttc agctgtattt ggaagagtca cccctctctg tgccgcaagc tgggctctct     3480

actgaagcgc aggcctcagg gcgagggccc taatccagtt gccggcagtt gggagccccc     3540

caaggcacat ccctatttcc ccgacttggt acagccgttg ctccccattt ctggtgacgt     3600

gtccccggtg tccaccggtc tccccgctgc cccagtcctg gaggctgggg tgcctcagca     3660

gcagagcccc ctggacctga cccgtgaacc tcagctggag ccaggagaac agagccaggt     3720

ggcgcatgga accaacggca tccacgtcac tggagggtcc atgaccatca ccggcaacat     3780

ctacatctac aacgggccag tgctgggagg tcccccaggc cctggcgatc tgccggctac     3840

cccggagcct ccttacccta tccccgagga gggcgacccg gggccgcccg gcttatcgac     3900

ccctcaccag gaggacggca aggcctggca cctcgccgag actgagcact gtggggccac     3960

ccccagcaac cgcggcccgc gcaatcagtt catcactcat gactgagaat tccgcccccc     4020

cccccccccc ccctctccct cccccccccc taacgttact ggccgaagcc gcttggaata     4080

aggccggtgt gcgtttgtct atatgttatt ttccaccata ttgccgtctt ttggcaatgt     4140

gagggcccgg aaacctggcc ctgtcttctt gacgagcatt cctaggggtc tttcccctct     4200

cgccaaagga atgcaaggtc tgttgaatgt cgtgaaggaa gcagttcctc tggaagcttc     4260

ttgaagacaa acaacgtctg tagcgaccct ttgcaggcag cggaaccccc cacctggcga     4320

caggtgcctc tgcggccaaa agccacgtgt ataagataca cctgcaaagg cggcacaacc     4380

ccagtgccac gttgtgagtt ggatagttgt ggaaagagtc aaatggctct cctcaagcgt     4440

attcaacaag gggctgaagg atgcccagaa ggtaccccat tgtatgggat ctgatctggg     4500

gcctcggtgc acatgcttta catgtgttta gtcgaggtta aaaaaacgtc taggcccccc     4560

gaaccacggg gacgtggttt tcctttgaaa aacacgatga taagcttgat cacgcgtgcc     4620

accatgagca agggcgagga gctgttcacc ggggtggtgc ccatcctggt cgagctggac     4680

ggcgacgtaa acggccacaa gttcagcgtg tccggcgagg gcgagggcga tgccacctac     4740

ggcaagctga ccctgaagtt catctgcacc accggcaagc tgcccgtgcc ctggcccacc     4800

ctcgtgacca ccctgaccta cggcgtgcag tgcttcagcc gctaccccga ccacatgaag     4860

cagcacgact tcttcaagtc cgccatgccc gaaggctacg tccaggagcg caccatcttc     4920

ttcaaggacg acggcaacta caagacccgc gccgaggtga agttcgaggg cgacaccctg     4980

gtgaaccgca tcgagctgaa gggcatcgac ttcaaggagg acggcaacat cctggggcac     5040

aagctggagt acaactacaa cagccacaac gtctatatca tggccgacaa gcagaagaac     5100

ggcatcaagg tgaacttcaa gatccgccac aacatcgagg acggcagcgt gcagctcgcc     5160

gaccactacc agcagaacac ccccatcggc gacggccccg tgctgctgcc cgacaaccac     5220

tacctgagca cccagtccgc cctgagcaaa gaccccaacg agaagcgcga tcacatggtc     5280

ctgctggagt tcgtgaccgc cgccgggatc actcacggca tggacgagct gtacaagtga     5340

gaattcgata tcaagcttat cggtaatcaa cctctggatt acaaaatttg tgaaagattg     5400

actggtattc ttaactatgt tgctcctttt acgctatgtg gatacgctgc tttaatgcct     5460

ttgtatcatg ctattgcttc ccgtatggct ttcattttct cctccttgta taaatcctgg     5520

ttgctgtctc tttatgagga gttgtggccc gttgtcaggc aacgtggcgt ggtgtgcact     5580

gtgtttgctg acgcaacccc cactggttgg ggcattgcca ccacctgtca gctcctttcc     5640

gggactttcg ctttccccct ccctattgcc acggcggaac tcatcgccgc ctgccttgcc     5700

cgctgctgga caggggctcg gctgttgggc actgacaatt ccgtggtgtt gtcggggaaa     5760

tcatcgtcct ttccttggct gctcgcctgt gttgccacct ggattctgcg cgggacgtcc     5820

ttctgctacg tcccttcggc cctcaatcca gcggaccttc cttcccgcgg cctgctgccg     5880

gctctgcggc ctcttccgcg tcttcgcctt cgccctcaga cgagtcggat ctccctttgg     5940

gccgcctccc cgcatcgata ccgtcgacct cgagacctag aaaaacatgg agcaatcaca     6000

agtagcaata cagcagctac caatgctgat tgtgcctggc tagaagcaca agaggaggag     6060

gaggtgggtt ttccagtcac acctcaggta cctttaagac caatgactta caaggcagct     6120

gtagatctta gccacttttt aaaagaaaag gggggactgg aagggctaat tcactcccaa     6180

cgaagacaag atatccttga tctgtggatc taccacacac aaggctactt ccctgattgg     6240

cagaactaca caccagggcc agggatcaga tatccactga cctttggatg gtgctacaag     6300

ctagtaccag ttgagcaaga gaaggtagaa gaagccaatg aaggagagaa cacccgcttg     6360

ttacaccctg tgagcctgca tgggatggat gacccggaga gagaagtatt agagtggagg     6420

tttgacagcc gcctagcatt tcatcacatg gcccgagagc tgcatccgga ctgtactggg     6480

tctctctggt tagaccagat ctgagcctgg gagctctctg gctaactagg gaacccactg     6540

cttaagcctc aataaagctt gccttgagtg cttcaagtag tgtgtgcccg tctgttgtgt     6600

gactctggta actagagatc cctcagaccc ttttagtcag tgtggaaaat ctctagcagg     6660

gcccgtttaa acccgctgat cagcctcgac tgtgccttct agttgccagc catctgttgt     6720

ttgcccctcc cccgtgcctt ccttgaccct ggaaggtgcc actcccactg tcctttccta     6780

ataaaatgag gaaattgcat cgcattgtct gagtaggtgt cattctattc tggggggtgg     6840

ggtggggcag gacagcaagg gggaggattg ggaagacaat agcaggcatg ctggggatgc     6900

ggtgggctct atggcttctg aggcggaaag aaccagctgg ggctctaggg ggtatcccca     6960

cgcgccctgt agcggcgcat taagcgcggc gggtgtggtg gttacgcgca gcgtgaccgc     7020

tacacttgcc agcgccctag cgcccgctcc tttcgctttc ttcccttcct ttctcgccac     7080

gttcgccggc tttccccgtc aagctctaaa tcgggggctc cctttagggt tccgatttag     7140

tgctttacgg cacctcgacc ccaaaaaact tgattagggt gatggttcac gtagtgggcc     7200

atcgccctga tagacggttt ttcgcccttt gacgttggag tccacgttct ttaatagtgg     7260

actcttgttc caaactggaa caacactcaa ccctatctcg gtctattctt ttgatttata     7320

agggattttg ccgatttcgg cctattggtt aaaaaatgag ctgatttaac aaaaatttaa     7380

cgcgaattaa ttctgtggaa tgtgtgtcag ttagggtgtg gaaagtcccc aggctcccca     7440

gcaggcagaa gtatgcaaag catgcatctc aattagtcag caaccaggtg tggaaagtcc     7500

ccaggctccc cagcaggcag aagtatgcaa agcatgcatc tcaattagtc agcaaccata     7560

gtcccgcccc taactccgcc catcccgccc ctaactccgc ccagttccgc ccattctccg     7620

ccccatggct gactaatttt ttttatttat gcagaggccg aggccgcctc tgcctctgag     7680

ctattccaga agtagtgagg aggctttttt ggaggcctag gcttttgcaa aaagctcccg     7740

ggagcttgta tatccatttt cggatctgat cagcacgtgt tgacaattaa tcatcggcat     7800

agtatatcgg catagtataa tacgacaagg tgaggaacta aaccatggcc aagttgacca     7860

gtgccgttcc ggtgctcacc gcgcgcgacg tcgccggagc ggtcgagttc tggaccgacc     7920

ggctcgggtt ctcccgggac ttcgtggagg acgacttcgc cggtgtggtc cgggacgacg     7980

tgaccctgtt catcagcgcg gtccaggacc aggtggtgcc ggacaacacc ctggcctggg     8040

tgtgggtgcg cggcctggac gagctgtacg ccgagtggtc ggaggtcgtg tccacgaact     8100

tccgggacgc ctccgggccg gccatgaccg agatcggcga gcagccgtgg gggcgggagt     8160

tcgccctgcg cgacccggcc ggcaactgcg tgcacttcgt ggccgaggag caggactgac     8220

acgtgctacg agatttcgat tccaccgccg ccttctatga aaggttgggc ttcggaatcg     8280

ttttccggga cgccggctgg atgatcctcc agcgcgggga tctcatgctg gagttcttcg     8340

cccaccccaa cttgtttatt gcagcttata atggttacaa ataaagcaat agcatcacaa     8400

atttcacaaa taaagcattt ttttcactgc attctagttg tggtttgtcc aaactcatca     8460

atgtatctta tcatgtctgt ataccgtcga cctctagcta gagcttggcg taatcatggt     8520

catagctgtt tcctgtgtga aattgttatc cgctcacaat tccacacaac atacgagccg     8580

gaagcataaa gtgtaaagcc tggggtgcct aatgagtgag ctaactcaca ttaattgcgt     8640

tgcgctcact gcccgctttc cagtcgggaa acctgtcgtg ccagctgcat taatgaatcg     8700

gccaacgcgc ggggagaggc ggtttgcgta ttgggcgctc ttccgcttcc tcgctcactg     8760

actcgctgcg ctcggtcgtt cggctgcggc gagcggtatc agctcactca aaggcggtaa     8820

tacggttatc cacagaatca ggggataacg caggaaagaa catgtgagca aaaggccagc     8880

aaaaggccag gaaccgtaaa aaggccgcgt tgctggcgtt tttccatagg ctccgccccc     8940

ctgacgagca tcacaaaaat cgacgctcaa gtcagaggtg gcgaaacccg acaggactat     9000

aaagatacca ggcgtttccc cctggaagct ccctcgtgcg ctctcctgtt ccgaccctgc     9060

cgcttaccgg atacctgtcc gcctttctcc cttcgggaag cgtggcgctt tctcatagct     9120

cacgctgtag gtatctcagt tcggtgtagg tcgttcgctc caagctgggc tgtgtgcacg     9180

aaccccccgt tcagcccgac cgctgcgcct tatccggtaa ctatcgtctt gagtccaacc     9240

cggtaagaca cgacttatcg ccactggcag cagccactgg taacaggatt agcagagcga     9300

ggtatgtagg cggtgctaca gagttcttga agtggtggcc taactacggc tacactagaa     9360

gaacagtatt tggtatctgc gctctgctga agccagttac cttcggaaaa agagttggta     9420

gctcttgatc cggcaaacaa accaccgctg gtagcggtgg tttttttgtt tgcaagcagc     9480

agattacgcg cagaaaaaaa ggatctcaag aagatccttt gatcttttct acggggtctg     9540

acgctcagtg gaacgaaaac tcacgttaag ggattttggt catgagatta tcaaaaagga     9600

tcttcaccta gatcctttta aattaaaaat gaagttttaa atcaatctaa agtatatatg     9660

agtaaacttg gtctgacagt taccaatgct taatcagtga ggcacctatc tcagcgatct     9720

gtctatttcg ttcatccata gttgcctgac tccccgtcgt gtagataact acgatacggg     9780

agggcttacc atctggcccc agtgctgcaa tgataccgcg agacccacgc tcaccggctc     9840

cagatttatc agcaataaac cagccagccg gaagggccga gcgcagaagt ggtcctgcaa     9900

ctttatccgc ctccatccag tctattaatt gttgccggga agctagagta agtagttcgc     9960

cagttaatag tttgcgcaac gttgttgcca ttgctacagg catcgtggtg tcacgctcgt    10020

cgtttggtat ggcttcattc agctccggtt cccaacgatc aaggcgagtt acatgatccc    10080

ccatgttgtg caaaaaagcg gttagctcct tcggtcctcc gatcgttgtc agaagtaagt    10140

tggccgcagt gttatcactc atggttatgg cagcactgca taattctctt actgtcatgc    10200

catccgtaag atgcttttct gtgactggtg agtactcaac caagtcattc tgagaatagt    10260

gtatgcggcg accgagttgc tcttgcccgg cgtcaatacg ggataatacc gcgccacata    10320

gcagaacttt aaaagtgctc atcattggaa aacgttcttc ggggcgaaaa ctctcaagga    10380

tcttaccgct gttgagatcc agttcgatgt aacccactcg tgcacccaac tgatcttcag    10440

catcttttac tttcaccagc gtttctgggt gagcaaaaac aggaaggcaa aatgccgcaa    10500

aaaagggaat aagggcgaca cggaaatgtt gaatactcat actcttcctt tttcaatatt    10560

attgaagcat ttatcagggt tattgtctca tgagcggata catatttgaa tgtatttaga    10620

aaaataaaca aataggggtt ccgcgcacat ttccccgaaa agtgccacct gac           10673


<210>  710
<211>  10709
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Synthetic nucleotide

<400>  710
gtcgacggat cgggagatct cccgatcccc tatggtgcac tctcagtaca atctgctctg       60

atgccgcata gttaagccag tatctgctcc ctgcttgtgt gttggaggtc gctgagtagt      120

gcgcgagcaa aatttaagct acaacaaggc aaggcttgac cgacaattgc atgaagaatc      180

tgcttagggt taggcgtttt gcgctgcttc gcgatgtacg ggccagatat acgcgttgac      240

attgattatt gactagttat taatagtaat caattacggg gtcattagtt catagcccat      300

atatggagtt ccgcgttaca taacttacgg taaatggccc gcctggctga ccgcccaacg      360

acccccgccc attgacgtca ataatgacgt atgttcccat agtaacgcca atagggactt      420

tccattgacg tcaatgggtg gagtatttac ggtaaactgc ccacttggca gtacatcaag      480

tgtatcatat gccaagtacg ccccctattg acgtcaatga cggtaaatgg cccgcctggc      540

attatgccca gtacatgacc ttatgggact ttcctacttg gcagtacatc tacgtattag      600

tcatcgctat taccatggtg atgcggtttt ggcagtacat caatgggcgt ggatagcggt      660

ttgactcacg gggatttcca agtctccacc ccattgacgt caatgggagt ttgttttggc      720

accaaaatca acgggacttt ccaaaatgtc gtaacaactc cgccccattg acgcaaatgg      780

gcggtaggcg tgtacggtgg gaggtctata taagcagcgc gttttgcctg tactgggtct      840

ctctggttag accagatctg agcctgggag ctctctggct aactagggaa cccactgctt      900

aagcctcaat aaagcttgcc ttgagtgctt caagtagtgt gtgcccgtct gttgtgtgac      960

tctggtaact agagatccct cagacccttt tagtcagtgt ggaaaatctc tagcagtggc     1020

gcccgaacag ggacttgaaa gcgaaaggga aaccagagga gctctctcga cgcaggactc     1080

ggcttgctga agcgcgcacg gcaagaggcg aggggcggcg actggtgagt acgccaaaaa     1140

ttttgactag cggaggctag aaggagagag atgggtgcga gagcgtcagt attaagcggg     1200

ggagaattag atcgcgatgg gaaaaaattc ggttaaggcc agggggaaag aaaaaatata     1260

aattaaaaca tatagtatgg gcaagcaggg agctagaacg attcgcagtt aatcctggcc     1320

tgttagaaac atcagaaggc tgtagacaaa tactgggaca gctacaacca tcccttcaga     1380

caggatcaga agaacttaga tcattatata atacagtagc aaccctctat tgtgtgcatc     1440

aaaggataga gataaaagac accaaggaag ctttagacaa gatagaggaa gagcaaaaca     1500

aaagtaagac caccgcacag caagcggccg ctgatcttca gacctggagg aggagatatg     1560

agggacaatt ggagaagtga attatataaa tataaagtag taaaaattga accattagga     1620

gtagcaccca ccaaggcaaa gagaagagtg gtgcagagag aaaaaagagc agtgggaata     1680

ggagctttgt tccttgggtt cttgggagca gcaggaagca ctatgggcgc agcgtcaatg     1740

acgctgacgg tacaggccag acaattattg tctggtatag tgcagcagca gaacaatttg     1800

ctgagggcta ttgaggcgca acagcatctg ttgcaactca cagtctgggg catcaagcag     1860

ctccaggcaa gaatcctggc tgtggaaaga tacctaaagg atcaacagct cctggggatt     1920

tggggttgct ctggaaaact catttgcacc actgctgtgc cttggaatgc tagttggagt     1980

aataaatctc tggaacagat ttggaatcac acgacctgga tggagtggga cagagaaatt     2040

aacaattaca caagcttaat acactcctta attgaagaat cgcaaaacca gcaagaaaag     2100

aatgaacaag aattattgga attagataaa tgggcaagtt tgtggaattg gtttaacata     2160

acaaattggc tgtggtatat aaaattattc ataatgatag taggaggctt ggtaggttta     2220

agaatagttt ttgctgtact ttctatagtg aatagagtta ggcagggata ttcaccatta     2280

tcgtttcaga cccacctccc aaccccgagg ggacccgaca ggcccgaagg aatagaagaa     2340

gaaggtggag agagagacag agacagatcc attcgattag tgaacggatc ggcactgcgt     2400

gcgccaattc tgcagacaaa tggcagtatt catccacaat tttaaaagaa aaggggggat     2460

tggggggtac agtgcagggg aaagaatagt agacataata gcaacagaca tacaaactaa     2520

agaattacaa aaacaaatta caaaaattca aaattttcgg gtttattaca gggacagcag     2580

agatccagtt tggttaatta gctagctagg tcttgaaagg agtgggaatt ggctccggtg     2640

cccgtcagtg ggcagagcgc acatcgccca cagtccccga gaagttgggg ggaggggtcg     2700

gcaattgatc cggtgcctag agaaggtggc gcggggtaaa ctgggaaagt gatgtcgtgt     2760

actggctccg cctttttccc gagggtgggg gagaaccgta tataagtgca gtagtcgccg     2820

tgaacgttct ttttcgcaac gggtttgccg ccagaacaca ggaccggttc tagagcgctt     2880

taattaagcc accatggatt ggacctggat cctatttctg gtggcggctg cgactcgggt     2940

gcactcgacc atcccgccgc acgttcagaa gtccgttaac aacgacatga tcgtgaccga     3000

caacaatggc gccgtgaaat tcccccagct gtgcaagttt tgcgacgtgc gcttttcaac     3060

ctgcgacaac cagaagtcat gcatgagcaa ctgctctatt accagcatct gcgagaagcc     3120

tcaggaggtg tgcgtggctg tctggcgtaa gaacgacgag aacatcaccc tggagaccgt     3180

ctgccacgac ccgaagttac cctatcacga tttcatactg gaagacgcag cctccccgaa     3240

gtgcatcatg aaggagaaaa agaagcctgg ggagaccttc ttcatgtgct cctgttcctc     3300

ggacgagtgt aacgacaaca tcatctttag cgaagagtac aacacgtcca atccagacct     3360

gctcctggta atcttccagc ctctgccccc cgagatgtct ggcaccatgc tgatgttggc     3420

cgtcctcctt ccgcttgcgt tcttcctgct tctggccacc gtgttcagtt gtatttggaa     3480

gagccaccct tctctgtgcc gaaagctggg ctccttgctc aaacgcaggc cccagggcga     3540

gggacccaat ccagtggctg gcagttggga gccgcccaag gcccatccct acttccccga     3600

cctggtgcag cctttgttac caatctctgg tgatgtcagc cccgtgtcca caggcctgcc     3660

tgccgcgccg gtgctggagg ccggggtgcc tcagcagcag tcgcccctag acctgacccg     3720

cgagccccaa ctggagccag gagaacagag ccaggtcgcg catggaacta atggcatcca     3780

cgtcaccggt ggctccatga cgatcaccgg caacatttac atctacaacg gtccggtgct     3840

gggcggccct ccggggcctg gtgatctgcc ggccacgcct gagcccccct accccatccc     3900

ggaggaggga gatccagggc cacctggcct ctccaccccc caccaggagg acggcaaagc     3960

ttggcacctc gcagagactg agcactgtgg cgctactccc tctaaccgcg gtccccgcaa     4020

ccagttcatt actcatgact gagaattccg cccccccccc ccccccccct ctccctcccc     4080

cccccctaac gttactggcc gaagccgctt ggaataaggc cggtgtgcgt ttgtctatat     4140

gttattttcc accatattgc cgtcttttgg caatgtgagg gcccggaaac ctggccctgt     4200

cttcttgacg agcattccta ggggtctttc ccctctcgcc aaaggaatgc aaggtctgtt     4260

gaatgtcgtg aaggaagcag ttcctctgga agcttcttga agacaaacaa cgtctgtagc     4320

gaccctttgc aggcagcgga accccccacc tggcgacagg tgcctctgcg gccaaaagcc     4380

acgtgtataa gatacacctg caaaggcggc acaaccccag tgccacgttg tgagttggat     4440

agttgtggaa agagtcaaat ggctctcctc aagcgtattc aacaaggggc tgaaggatgc     4500

ccagaaggta ccccattgta tgggatctga tctggggcct cggtgcacat gctttacatg     4560

tgtttagtcg aggttaaaaa aacgtctagg ccccccgaac cacggggacg tggttttcct     4620

ttgaaaaaca cgatgataag cttgatcacg cgtgccacca tgagcaaggg cgaggagctg     4680

ttcaccgggg tggtgcccat cctggtcgag ctggacggcg acgtaaacgg ccacaagttc     4740

agcgtgtccg gcgagggcga gggcgatgcc acctacggca agctgaccct gaagttcatc     4800

tgcaccaccg gcaagctgcc cgtgccctgg cccaccctcg tgaccaccct gacctacggc     4860

gtgcagtgct tcagccgcta ccccgaccac atgaagcagc acgacttctt caagtccgcc     4920

atgcccgaag gctacgtcca ggagcgcacc atcttcttca aggacgacgg caactacaag     4980

acccgcgccg aggtgaagtt cgagggcgac accctggtga accgcatcga gctgaagggc     5040

atcgacttca aggaggacgg caacatcctg gggcacaagc tggagtacaa ctacaacagc     5100

cacaacgtct atatcatggc cgacaagcag aagaacggca tcaaggtgaa cttcaagatc     5160

cgccacaaca tcgaggacgg cagcgtgcag ctcgccgacc actaccagca gaacaccccc     5220

atcggcgacg gccccgtgct gctgcccgac aaccactacc tgagcaccca gtccgccctg     5280

agcaaagacc ccaacgagaa gcgcgatcac atggtcctgc tggagttcgt gaccgccgcc     5340

gggatcactc acggcatgga cgagctgtac aagtgagaat tcgatatcaa gcttatcggt     5400

aatcaacctc tggattacaa aatttgtgaa agattgactg gtattcttaa ctatgttgct     5460

ccttttacgc tatgtggata cgctgcttta atgcctttgt atcatgctat tgcttcccgt     5520

atggctttca ttttctcctc cttgtataaa tcctggttgc tgtctcttta tgaggagttg     5580

tggcccgttg tcaggcaacg tggcgtggtg tgcactgtgt ttgctgacgc aacccccact     5640

ggttggggca ttgccaccac ctgtcagctc ctttccggga ctttcgcttt ccccctccct     5700

attgccacgg cggaactcat cgccgcctgc cttgcccgct gctggacagg ggctcggctg     5760

ttgggcactg acaattccgt ggtgttgtcg gggaaatcat cgtcctttcc ttggctgctc     5820

gcctgtgttg ccacctggat tctgcgcggg acgtccttct gctacgtccc ttcggccctc     5880

aatccagcgg accttccttc ccgcggcctg ctgccggctc tgcggcctct tccgcgtctt     5940

cgccttcgcc ctcagacgag tcggatctcc ctttgggccg cctccccgca tcgataccgt     6000

cgacctcgag acctagaaaa acatggagca atcacaagta gcaatacagc agctaccaat     6060

gctgattgtg cctggctaga agcacaagag gaggaggagg tgggttttcc agtcacacct     6120

caggtacctt taagaccaat gacttacaag gcagctgtag atcttagcca ctttttaaaa     6180

gaaaaggggg gactggaagg gctaattcac tcccaacgaa gacaagatat ccttgatctg     6240

tggatctacc acacacaagg ctacttccct gattggcaga actacacacc agggccaggg     6300

atcagatatc cactgacctt tggatggtgc tacaagctag taccagttga gcaagagaag     6360

gtagaagaag ccaatgaagg agagaacacc cgcttgttac accctgtgag cctgcatggg     6420

atggatgacc cggagagaga agtattagag tggaggtttg acagccgcct agcatttcat     6480

cacatggccc gagagctgca tccggactgt actgggtctc tctggttaga ccagatctga     6540

gcctgggagc tctctggcta actagggaac ccactgctta agcctcaata aagcttgcct     6600

tgagtgcttc aagtagtgtg tgcccgtctg ttgtgtgact ctggtaacta gagatccctc     6660

agaccctttt agtcagtgtg gaaaatctct agcagggccc gtttaaaccc gctgatcagc     6720

ctcgactgtg ccttctagtt gccagccatc tgttgtttgc ccctcccccg tgccttcctt     6780

gaccctggaa ggtgccactc ccactgtcct ttcctaataa aatgaggaaa ttgcatcgca     6840

ttgtctgagt aggtgtcatt ctattctggg gggtggggtg gggcaggaca gcaaggggga     6900

ggattgggaa gacaatagca ggcatgctgg ggatgcggtg ggctctatgg cttctgaggc     6960

ggaaagaacc agctggggct ctagggggta tccccacgcg ccctgtagcg gcgcattaag     7020

cgcggcgggt gtggtggtta cgcgcagcgt gaccgctaca cttgccagcg ccctagcgcc     7080

cgctcctttc gctttcttcc cttcctttct cgccacgttc gccggctttc cccgtcaagc     7140

tctaaatcgg gggctccctt tagggttccg atttagtgct ttacggcacc tcgaccccaa     7200

aaaacttgat tagggtgatg gttcacgtag tgggccatcg ccctgataga cggtttttcg     7260

ccctttgacg ttggagtcca cgttctttaa tagtggactc ttgttccaaa ctggaacaac     7320

actcaaccct atctcggtct attcttttga tttataaggg attttgccga tttcggccta     7380

ttggttaaaa aatgagctga tttaacaaaa atttaacgcg aattaattct gtggaatgtg     7440

tgtcagttag ggtgtggaaa gtccccaggc tccccagcag gcagaagtat gcaaagcatg     7500

catctcaatt agtcagcaac caggtgtgga aagtccccag gctccccagc aggcagaagt     7560

atgcaaagca tgcatctcaa ttagtcagca accatagtcc cgcccctaac tccgcccatc     7620

ccgcccctaa ctccgcccag ttccgcccat tctccgcccc atggctgact aatttttttt     7680

atttatgcag aggccgaggc cgcctctgcc tctgagctat tccagaagta gtgaggaggc     7740

ttttttggag gcctaggctt ttgcaaaaag ctcccgggag cttgtatatc cattttcgga     7800

tctgatcagc acgtgttgac aattaatcat cggcatagta tatcggcata gtataatacg     7860

acaaggtgag gaactaaacc atggccaagt tgaccagtgc cgttccggtg ctcaccgcgc     7920

gcgacgtcgc cggagcggtc gagttctgga ccgaccggct cgggttctcc cgggacttcg     7980

tggaggacga cttcgccggt gtggtccggg acgacgtgac cctgttcatc agcgcggtcc     8040

aggaccaggt ggtgccggac aacaccctgg cctgggtgtg ggtgcgcggc ctggacgagc     8100

tgtacgccga gtggtcggag gtcgtgtcca cgaacttccg ggacgcctcc gggccggcca     8160

tgaccgagat cggcgagcag ccgtgggggc gggagttcgc cctgcgcgac ccggccggca     8220

actgcgtgca cttcgtggcc gaggagcagg actgacacgt gctacgagat ttcgattcca     8280

ccgccgcctt ctatgaaagg ttgggcttcg gaatcgtttt ccgggacgcc ggctggatga     8340

tcctccagcg cggggatctc atgctggagt tcttcgccca ccccaacttg tttattgcag     8400

cttataatgg ttacaaataa agcaatagca tcacaaattt cacaaataaa gcattttttt     8460

cactgcattc tagttgtggt ttgtccaaac tcatcaatgt atcttatcat gtctgtatac     8520

cgtcgacctc tagctagagc ttggcgtaat catggtcata gctgtttcct gtgtgaaatt     8580

gttatccgct cacaattcca cacaacatac gagccggaag cataaagtgt aaagcctggg     8640

gtgcctaatg agtgagctaa ctcacattaa ttgcgttgcg ctcactgccc gctttccagt     8700

cgggaaacct gtcgtgccag ctgcattaat gaatcggcca acgcgcgggg agaggcggtt     8760

tgcgtattgg gcgctcttcc gcttcctcgc tcactgactc gctgcgctcg gtcgttcggc     8820

tgcggcgagc ggtatcagct cactcaaagg cggtaatacg gttatccaca gaatcagggg     8880

ataacgcagg aaagaacatg tgagcaaaag gccagcaaaa ggccaggaac cgtaaaaagg     8940

ccgcgttgct ggcgtttttc cataggctcc gcccccctga cgagcatcac aaaaatcgac     9000

gctcaagtca gaggtggcga aacccgacag gactataaag ataccaggcg tttccccctg     9060

gaagctccct cgtgcgctct cctgttccga ccctgccgct taccggatac ctgtccgcct     9120

ttctcccttc gggaagcgtg gcgctttctc atagctcacg ctgtaggtat ctcagttcgg     9180

tgtaggtcgt tcgctccaag ctgggctgtg tgcacgaacc ccccgttcag cccgaccgct     9240

gcgccttatc cggtaactat cgtcttgagt ccaacccggt aagacacgac ttatcgccac     9300

tggcagcagc cactggtaac aggattagca gagcgaggta tgtaggcggt gctacagagt     9360

tcttgaagtg gtggcctaac tacggctaca ctagaagaac agtatttggt atctgcgctc     9420

tgctgaagcc agttaccttc ggaaaaagag ttggtagctc ttgatccggc aaacaaacca     9480

ccgctggtag cggtggtttt tttgtttgca agcagcagat tacgcgcaga aaaaaaggat     9540

ctcaagaaga tcctttgatc ttttctacgg ggtctgacgc tcagtggaac gaaaactcac     9600

gttaagggat tttggtcatg agattatcaa aaaggatctt cacctagatc cttttaaatt     9660

aaaaatgaag ttttaaatca atctaaagta tatatgagta aacttggtct gacagttacc     9720

aatgcttaat cagtgaggca cctatctcag cgatctgtct atttcgttca tccatagttg     9780

cctgactccc cgtcgtgtag ataactacga tacgggaggg cttaccatct ggccccagtg     9840

ctgcaatgat accgcgagac ccacgctcac cggctccaga tttatcagca ataaaccagc     9900

cagccggaag ggccgagcgc agaagtggtc ctgcaacttt atccgcctcc atccagtcta     9960

ttaattgttg ccgggaagct agagtaagta gttcgccagt taatagtttg cgcaacgttg    10020

ttgccattgc tacaggcatc gtggtgtcac gctcgtcgtt tggtatggct tcattcagct    10080

ccggttccca acgatcaagg cgagttacat gatcccccat gttgtgcaaa aaagcggtta    10140

gctccttcgg tcctccgatc gttgtcagaa gtaagttggc cgcagtgtta tcactcatgg    10200

ttatggcagc actgcataat tctcttactg tcatgccatc cgtaagatgc ttttctgtga    10260

ctggtgagta ctcaaccaag tcattctgag aatagtgtat gcggcgaccg agttgctctt    10320

gcccggcgtc aatacgggat aataccgcgc cacatagcag aactttaaaa gtgctcatca    10380

ttggaaaacg ttcttcgggg cgaaaactct caaggatctt accgctgttg agatccagtt    10440

cgatgtaacc cactcgtgca cccaactgat cttcagcatc ttttactttc accagcgttt    10500

ctgggtgagc aaaaacagga aggcaaaatg ccgcaaaaaa gggaataagg gcgacacgga    10560

aatgttgaat actcatactc ttcctttttc aatattattg aagcatttat cagggttatt    10620

gtctcatgag cggatacata tttgaatgta tttagaaaaa taaacaaata ggggttccgc    10680

gcacatttcc ccgaaaagtg ccacctgac                                      10709


<210>  711
<211>  10721
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Synthetic nucleotide

<400>  711
gtcgacggat cgggagatct cccgatcccc tatggtgcac tctcagtaca atctgctctg       60

atgccgcata gttaagccag tatctgctcc ctgcttgtgt gttggaggtc gctgagtagt      120

gcgcgagcaa aatttaagct acaacaaggc aaggcttgac cgacaattgc atgaagaatc      180

tgcttagggt taggcgtttt gcgctgcttc gcgatgtacg ggccagatat acgcgttgac      240

attgattatt gactagttat taatagtaat caattacggg gtcattagtt catagcccat      300

atatggagtt ccgcgttaca taacttacgg taaatggccc gcctggctga ccgcccaacg      360

acccccgccc attgacgtca ataatgacgt atgttcccat agtaacgcca atagggactt      420

tccattgacg tcaatgggtg gagtatttac ggtaaactgc ccacttggca gtacatcaag      480

tgtatcatat gccaagtacg ccccctattg acgtcaatga cggtaaatgg cccgcctggc      540

attatgccca gtacatgacc ttatgggact ttcctacttg gcagtacatc tacgtattag      600

tcatcgctat taccatggtg atgcggtttt ggcagtacat caatgggcgt ggatagcggt      660

ttgactcacg gggatttcca agtctccacc ccattgacgt caatgggagt ttgttttggc      720

accaaaatca acgggacttt ccaaaatgtc gtaacaactc cgccccattg acgcaaatgg      780

gcggtaggcg tgtacggtgg gaggtctata taagcagcgc gttttgcctg tactgggtct      840

ctctggttag accagatctg agcctgggag ctctctggct aactagggaa cccactgctt      900

aagcctcaat aaagcttgcc ttgagtgctt caagtagtgt gtgcccgtct gttgtgtgac      960

tctggtaact agagatccct cagacccttt tagtcagtgt ggaaaatctc tagcagtggc     1020

gcccgaacag ggacttgaaa gcgaaaggga aaccagagga gctctctcga cgcaggactc     1080

ggcttgctga agcgcgcacg gcaagaggcg aggggcggcg actggtgagt acgccaaaaa     1140

ttttgactag cggaggctag aaggagagag atgggtgcga gagcgtcagt attaagcggg     1200

ggagaattag atcgcgatgg gaaaaaattc ggttaaggcc agggggaaag aaaaaatata     1260

aattaaaaca tatagtatgg gcaagcaggg agctagaacg attcgcagtt aatcctggcc     1320

tgttagaaac atcagaaggc tgtagacaaa tactgggaca gctacaacca tcccttcaga     1380

caggatcaga agaacttaga tcattatata atacagtagc aaccctctat tgtgtgcatc     1440

aaaggataga gataaaagac accaaggaag ctttagacaa gatagaggaa gagcaaaaca     1500

aaagtaagac caccgcacag caagcggccg ctgatcttca gacctggagg aggagatatg     1560

agggacaatt ggagaagtga attatataaa tataaagtag taaaaattga accattagga     1620

gtagcaccca ccaaggcaaa gagaagagtg gtgcagagag aaaaaagagc agtgggaata     1680

ggagctttgt tccttgggtt cttgggagca gcaggaagca ctatgggcgc agcgtcaatg     1740

acgctgacgg tacaggccag acaattattg tctggtatag tgcagcagca gaacaatttg     1800

ctgagggcta ttgaggcgca acagcatctg ttgcaactca cagtctgggg catcaagcag     1860

ctccaggcaa gaatcctggc tgtggaaaga tacctaaagg atcaacagct cctggggatt     1920

tggggttgct ctggaaaact catttgcacc actgctgtgc cttggaatgc tagttggagt     1980

aataaatctc tggaacagat ttggaatcac acgacctgga tggagtggga cagagaaatt     2040

aacaattaca caagcttaat acactcctta attgaagaat cgcaaaacca gcaagaaaag     2100

aatgaacaag aattattgga attagataaa tgggcaagtt tgtggaattg gtttaacata     2160

acaaattggc tgtggtatat aaaattattc ataatgatag taggaggctt ggtaggttta     2220

agaatagttt ttgctgtact ttctatagtg aatagagtta ggcagggata ttcaccatta     2280

tcgtttcaga cccacctccc aaccccgagg ggacccgaca ggcccgaagg aatagaagaa     2340

gaaggtggag agagagacag agacagatcc attcgattag tgaacggatc ggcactgcgt     2400

gcgccaattc tgcagacaaa tggcagtatt catccacaat tttaaaagaa aaggggggat     2460

tggggggtac agtgcagggg aaagaatagt agacataata gcaacagaca tacaaactaa     2520

agaattacaa aaacaaatta caaaaattca aaattttcgg gtttattaca gggacagcag     2580

agatccagtt tggttaatta gctagctagg tcttgaaagg agtgggaatt ggctccggtg     2640

cccgtcagtg ggcagagcgc acatcgccca cagtccccga gaagttgggg ggaggggtcg     2700

gcaattgatc cggtgcctag agaaggtggc gcggggtaaa ctgggaaagt gatgtcgtgt     2760

actggctccg cctttttccc gagggtgggg gagaaccgta tataagtgca gtagtcgccg     2820

tgaacgttct ttttcgcaac gggtttgccg ccagaacaca ggaccggttc tagagcgctt     2880

taattaagcc accatggatt ggacctggat cctgttcctg gtggctgcgg ctacacgggt     2940

ccactcacag gtcaccgaca ttaactcgaa gggcctggag ctgcgcaaga ctgtgacgac     3000

cgtggagacc cagaacctgg aaggtttgca ccacgatgga cagttttgtc acaagccctg     3060

cccgcctggt gagcggaagg cccgcgactg taccgtcaac ggagacgagc ccgactgcgt     3120

gccttgccag gagggcaaag agtacaccga caaggcccac tttagctcca aatgccgtag     3180

gtgtcgcctg tgcgacgagg gccacgggct ggaggtggag atcaactgca ctcgcaccca     3240

gaacacgaaa tgcagatgta agcctaactt tttctgtaat tccaccgttt gcgagcactg     3300

tgatccatgc accaagtgcg agcacggtat catcaaggag tgcactctga cctccaatac     3360

gaagtgcaag gaggagggtt cccgcagcaa tccactgccc cccgagatgt ctggcaccat     3420

gctgatgctc gcggtgctgc tccctctagc gttcttcctg ctgcttgcca ccgtattcag     3480

ctgtatttgg aagagccacc cctcactgtg ccgtaagctc ggctctctgc tgaagcgccg     3540

acctcaggga gagggaccca accctgtggc tgggagttgg gagccgccca aggcccatcc     3600

ctatttcccg gatcttgtgc agccattact ccccatctct ggtgacgtgt ccccagtgtc     3660

gaccggcctt ccggccgctc cggttctaga agcaggcgtg ccccaacagc agtccccctt     3720

ggacctgact cgtgagccgc agctggagcc cggggaacag tcccaggtgg cgcatggcac     3780

caacggcatc catgtcacag gcggctccat gaccatcacc gggaacatct acatatacaa     3840

cggtccggtg ctgggtgggc ctcccggccc tggggacctt cccgcaactc cggaaccacc     3900

ctacccaatc cctgaggagg gtgacccggg acccccgggc ctctctaccc cccaccagga     3960

ggacggcaaa gcctggcact tggccgagac cgagcactgt ggcgctactc ctagcaaccg     4020

cggcccgcgc aaccagttca ttactcatga ctgagaattc cgcccccccc cccccccccc     4080

ctctccctcc ccccccccta acgttactgg ccgaagccgc ttggaataag gccggtgtgc     4140

gtttgtctat atgttatttt ccaccatatt gccgtctttt ggcaatgtga gggcccggaa     4200

acctggccct gtcttcttga cgagcattcc taggggtctt tcccctctcg ccaaaggaat     4260

gcaaggtctg ttgaatgtcg tgaaggaagc agttcctctg gaagcttctt gaagacaaac     4320

aacgtctgta gcgacccttt gcaggcagcg gaacccccca cctggcgaca ggtgcctctg     4380

cggccaaaag ccacgtgtat aagatacacc tgcaaaggcg gcacaacccc agtgccacgt     4440

tgtgagttgg atagttgtgg aaagagtcaa atggctctcc tcaagcgtat tcaacaaggg     4500

gctgaaggat gcccagaagg taccccattg tatgggatct gatctggggc ctcggtgcac     4560

atgctttaca tgtgtttagt cgaggttaaa aaaacgtcta ggccccccga accacgggga     4620

cgtggttttc ctttgaaaaa cacgatgata agcttgatca cgcgtgccac catgagcaag     4680

ggcgaggagc tgttcaccgg ggtggtgccc atcctggtcg agctggacgg cgacgtaaac     4740

ggccacaagt tcagcgtgtc cggcgagggc gagggcgatg ccacctacgg caagctgacc     4800

ctgaagttca tctgcaccac cggcaagctg cccgtgccct ggcccaccct cgtgaccacc     4860

ctgacctacg gcgtgcagtg cttcagccgc taccccgacc acatgaagca gcacgacttc     4920

ttcaagtccg ccatgcccga aggctacgtc caggagcgca ccatcttctt caaggacgac     4980

ggcaactaca agacccgcgc cgaggtgaag ttcgagggcg acaccctggt gaaccgcatc     5040

gagctgaagg gcatcgactt caaggaggac ggcaacatcc tggggcacaa gctggagtac     5100

aactacaaca gccacaacgt ctatatcatg gccgacaagc agaagaacgg catcaaggtg     5160

aacttcaaga tccgccacaa catcgaggac ggcagcgtgc agctcgccga ccactaccag     5220

cagaacaccc ccatcggcga cggccccgtg ctgctgcccg acaaccacta cctgagcacc     5280

cagtccgccc tgagcaaaga ccccaacgag aagcgcgatc acatggtcct gctggagttc     5340

gtgaccgccg ccgggatcac tcacggcatg gacgagctgt acaagtgaga attcgatatc     5400

aagcttatcg gtaatcaacc tctggattac aaaatttgtg aaagattgac tggtattctt     5460

aactatgttg ctccttttac gctatgtgga tacgctgctt taatgccttt gtatcatgct     5520

attgcttccc gtatggcttt cattttctcc tccttgtata aatcctggtt gctgtctctt     5580

tatgaggagt tgtggcccgt tgtcaggcaa cgtggcgtgg tgtgcactgt gtttgctgac     5640

gcaaccccca ctggttgggg cattgccacc acctgtcagc tcctttccgg gactttcgct     5700

ttccccctcc ctattgccac ggcggaactc atcgccgcct gccttgcccg ctgctggaca     5760

ggggctcggc tgttgggcac tgacaattcc gtggtgttgt cggggaaatc atcgtccttt     5820

ccttggctgc tcgcctgtgt tgccacctgg attctgcgcg ggacgtcctt ctgctacgtc     5880

ccttcggccc tcaatccagc ggaccttcct tcccgcggcc tgctgccggc tctgcggcct     5940

cttccgcgtc ttcgccttcg ccctcagacg agtcggatct ccctttgggc cgcctccccg     6000

catcgatacc gtcgacctcg agacctagaa aaacatggag caatcacaag tagcaataca     6060

gcagctacca atgctgattg tgcctggcta gaagcacaag aggaggagga ggtgggtttt     6120

ccagtcacac ctcaggtacc tttaagacca atgacttaca aggcagctgt agatcttagc     6180

cactttttaa aagaaaaggg gggactggaa gggctaattc actcccaacg aagacaagat     6240

atccttgatc tgtggatcta ccacacacaa ggctacttcc ctgattggca gaactacaca     6300

ccagggccag ggatcagata tccactgacc tttggatggt gctacaagct agtaccagtt     6360

gagcaagaga aggtagaaga agccaatgaa ggagagaaca cccgcttgtt acaccctgtg     6420

agcctgcatg ggatggatga cccggagaga gaagtattag agtggaggtt tgacagccgc     6480

ctagcatttc atcacatggc ccgagagctg catccggact gtactgggtc tctctggtta     6540

gaccagatct gagcctggga gctctctggc taactaggga acccactgct taagcctcaa     6600

taaagcttgc cttgagtgct tcaagtagtg tgtgcccgtc tgttgtgtga ctctggtaac     6660

tagagatccc tcagaccctt ttagtcagtg tggaaaatct ctagcagggc ccgtttaaac     6720

ccgctgatca gcctcgactg tgccttctag ttgccagcca tctgttgttt gcccctcccc     6780

cgtgccttcc ttgaccctgg aaggtgccac tcccactgtc ctttcctaat aaaatgagga     6840

aattgcatcg cattgtctga gtaggtgtca ttctattctg gggggtgggg tggggcagga     6900

cagcaagggg gaggattggg aagacaatag caggcatgct ggggatgcgg tgggctctat     6960

ggcttctgag gcggaaagaa ccagctgggg ctctaggggg tatccccacg cgccctgtag     7020

cggcgcatta agcgcggcgg gtgtggtggt tacgcgcagc gtgaccgcta cacttgccag     7080

cgccctagcg cccgctcctt tcgctttctt cccttccttt ctcgccacgt tcgccggctt     7140

tccccgtcaa gctctaaatc gggggctccc tttagggttc cgatttagtg ctttacggca     7200

cctcgacccc aaaaaacttg attagggtga tggttcacgt agtgggccat cgccctgata     7260

gacggttttt cgccctttga cgttggagtc cacgttcttt aatagtggac tcttgttcca     7320

aactggaaca acactcaacc ctatctcggt ctattctttt gatttataag ggattttgcc     7380

gatttcggcc tattggttaa aaaatgagct gatttaacaa aaatttaacg cgaattaatt     7440

ctgtggaatg tgtgtcagtt agggtgtgga aagtccccag gctccccagc aggcagaagt     7500

atgcaaagca tgcatctcaa ttagtcagca accaggtgtg gaaagtcccc aggctcccca     7560

gcaggcagaa gtatgcaaag catgcatctc aattagtcag caaccatagt cccgccccta     7620

actccgccca tcccgcccct aactccgccc agttccgccc attctccgcc ccatggctga     7680

ctaatttttt ttatttatgc agaggccgag gccgcctctg cctctgagct attccagaag     7740

tagtgaggag gcttttttgg aggcctaggc ttttgcaaaa agctcccggg agcttgtata     7800

tccattttcg gatctgatca gcacgtgttg acaattaatc atcggcatag tatatcggca     7860

tagtataata cgacaaggtg aggaactaaa ccatggccaa gttgaccagt gccgttccgg     7920

tgctcaccgc gcgcgacgtc gccggagcgg tcgagttctg gaccgaccgg ctcgggttct     7980

cccgggactt cgtggaggac gacttcgccg gtgtggtccg ggacgacgtg accctgttca     8040

tcagcgcggt ccaggaccag gtggtgccgg acaacaccct ggcctgggtg tgggtgcgcg     8100

gcctggacga gctgtacgcc gagtggtcgg aggtcgtgtc cacgaacttc cgggacgcct     8160

ccgggccggc catgaccgag atcggcgagc agccgtgggg gcgggagttc gccctgcgcg     8220

acccggccgg caactgcgtg cacttcgtgg ccgaggagca ggactgacac gtgctacgag     8280

atttcgattc caccgccgcc ttctatgaaa ggttgggctt cggaatcgtt ttccgggacg     8340

ccggctggat gatcctccag cgcggggatc tcatgctgga gttcttcgcc caccccaact     8400

tgtttattgc agcttataat ggttacaaat aaagcaatag catcacaaat ttcacaaata     8460

aagcattttt ttcactgcat tctagttgtg gtttgtccaa actcatcaat gtatcttatc     8520

atgtctgtat accgtcgacc tctagctaga gcttggcgta atcatggtca tagctgtttc     8580

ctgtgtgaaa ttgttatccg ctcacaattc cacacaacat acgagccgga agcataaagt     8640

gtaaagcctg gggtgcctaa tgagtgagct aactcacatt aattgcgttg cgctcactgc     8700

ccgctttcca gtcgggaaac ctgtcgtgcc agctgcatta atgaatcggc caacgcgcgg     8760

ggagaggcgg tttgcgtatt gggcgctctt ccgcttcctc gctcactgac tcgctgcgct     8820

cggtcgttcg gctgcggcga gcggtatcag ctcactcaaa ggcggtaata cggttatcca     8880

cagaatcagg ggataacgca ggaaagaaca tgtgagcaaa aggccagcaa aaggccagga     8940

accgtaaaaa ggccgcgttg ctggcgtttt tccataggct ccgcccccct gacgagcatc     9000

acaaaaatcg acgctcaagt cagaggtggc gaaacccgac aggactataa agataccagg     9060

cgtttccccc tggaagctcc ctcgtgcgct ctcctgttcc gaccctgccg cttaccggat     9120

acctgtccgc ctttctccct tcgggaagcg tggcgctttc tcatagctca cgctgtaggt     9180

atctcagttc ggtgtaggtc gttcgctcca agctgggctg tgtgcacgaa ccccccgttc     9240

agcccgaccg ctgcgcctta tccggtaact atcgtcttga gtccaacccg gtaagacacg     9300

acttatcgcc actggcagca gccactggta acaggattag cagagcgagg tatgtaggcg     9360

gtgctacaga gttcttgaag tggtggccta actacggcta cactagaaga acagtatttg     9420

gtatctgcgc tctgctgaag ccagttacct tcggaaaaag agttggtagc tcttgatccg     9480

gcaaacaaac caccgctggt agcggtggtt tttttgtttg caagcagcag attacgcgca     9540

gaaaaaaagg atctcaagaa gatcctttga tcttttctac ggggtctgac gctcagtgga     9600

acgaaaactc acgttaaggg attttggtca tgagattatc aaaaaggatc ttcacctaga     9660

tccttttaaa ttaaaaatga agttttaaat caatctaaag tatatatgag taaacttggt     9720

ctgacagtta ccaatgctta atcagtgagg cacctatctc agcgatctgt ctatttcgtt     9780

catccatagt tgcctgactc cccgtcgtgt agataactac gatacgggag ggcttaccat     9840

ctggccccag tgctgcaatg ataccgcgag acccacgctc accggctcca gatttatcag     9900

caataaacca gccagccgga agggccgagc gcagaagtgg tcctgcaact ttatccgcct     9960

ccatccagtc tattaattgt tgccgggaag ctagagtaag tagttcgcca gttaatagtt    10020

tgcgcaacgt tgttgccatt gctacaggca tcgtggtgtc acgctcgtcg tttggtatgg    10080

cttcattcag ctccggttcc caacgatcaa ggcgagttac atgatccccc atgttgtgca    10140

aaaaagcggt tagctccttc ggtcctccga tcgttgtcag aagtaagttg gccgcagtgt    10200

tatcactcat ggttatggca gcactgcata attctcttac tgtcatgcca tccgtaagat    10260

gcttttctgt gactggtgag tactcaacca agtcattctg agaatagtgt atgcggcgac    10320

cgagttgctc ttgcccggcg tcaatacggg ataataccgc gccacatagc agaactttaa    10380

aagtgctcat cattggaaaa cgttcttcgg ggcgaaaact ctcaaggatc ttaccgctgt    10440

tgagatccag ttcgatgtaa cccactcgtg cacccaactg atcttcagca tcttttactt    10500

tcaccagcgt ttctgggtga gcaaaaacag gaaggcaaaa tgccgcaaaa aagggaataa    10560

gggcgacacg gaaatgttga atactcatac tcttcctttt tcaatattat tgaagcattt    10620

atcagggtta ttgtctcatg agcggataca tatttgaatg tatttagaaa aataaacaaa    10680

taggggttcc gcgcacattt ccccgaaaag tgccacctga c                        10721


<210>  712
<211>  355
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic amino acid

<400>  712

Met Ala Leu Pro Val Thr Ala Leu Leu Leu Pro Leu Ala Leu Leu Leu 
1               5                   10                  15      


His Ala Ala Arg Pro Asn Phe Met Leu Thr Gln Pro His Ser Val Ser 
            20                  25                  30          


Glu Ser Leu Gly Lys Thr Val Thr Ile Ser Cys Thr Gly Ser Ser Gly 
        35                  40                  45              


Ser Ile Ala Arg Lys Phe Val Gln Trp Tyr Gln Gln Arg Pro Gly Ser 
    50                  55                  60                  


Ser Pro Thr Thr Val Ile Tyr Glu Asn Asn Gln Arg Pro Ser Gly Val 
65                  70                  75                  80  


Ser Asp Arg Phe Ser Gly Ser Ile Gly Ser Ser Ser Asn Ser Ala Ser 
                85                  90                  95      


Leu Thr Ile Ser Gly Leu Lys Thr Glu Asp Glu Ala Asp Tyr Tyr Cys 
            100                 105                 110         


Gln Ser Tyr Asp Ser Ser Asn Val Val Phe Gly Gly Gly Thr Lys Val 
        115                 120                 125             


Thr Val Leu Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser Gly Gly Gly 
    130                 135                 140                 


Gly Ser Gly Gly Gly Gly Ser Gln Val Gln Leu Gln Glu Ser Gly Gly 
145                 150                 155                 160 


Gly Leu Val Lys Pro Gly Gly Ser Leu Arg Leu Ser Cys Ala Ala Ser 
                165                 170                 175     


Gly Phe Thr Phe Ser Ser Tyr Ser Met Asn Trp Val Arg Gln Ala Pro 
            180                 185                 190         


Gly Lys Gly Leu Glu Trp Val Ser Gly Ile Asn Thr Ala Gly Asp Thr 
        195                 200                 205             


His Tyr Pro Glu Ser Val Lys Gly Arg Phe Thr Ile Ser Arg Asp Asn 
    210                 215                 220                 


Ala Arg Asn Ser Leu Asn Leu Gln Met Asn Ser Leu Arg Ala Glu Asp 
225                 230                 235                 240 


Thr Ala Val Tyr Tyr Cys Val Arg Glu Arg Val Glu Arg Glu Tyr Ser 
                245                 250                 255     


Gly Tyr Asp Ala Phe Asp Ile Trp Gly Gln Gly Thr Thr Val Thr Val 
            260                 265                 270         


Ser Ala Pro Ala Pro Ala Arg Glu Pro Gly His Ser Pro Gln Ile Ile 
        275                 280                 285             


Ser Phe Phe Leu Ala Leu Thr Ser Thr Ala Leu Leu Phe Leu Leu Phe 
    290                 295                 300                 


Phe Leu Thr Leu Arg Phe Ser Val Val Lys Arg Gly Arg Lys Lys Leu 
305                 310                 315                 320 


Leu Tyr Ile Phe Lys Gln Pro Phe Met Arg Pro Val Gln Thr Thr Gln 
                325                 330                 335     


Glu Glu Asp Gly Cys Ser Cys Arg Phe Pro Glu Glu Glu Glu Gly Gly 
            340                 345                 350         


Cys Glu Leu 
        355 


<210>  713
<211>  494
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic amino acid

<400>  713

Met Ala Leu Pro Val Thr Ala Leu Leu Leu Pro Leu Ala Leu Leu Leu 
1               5                   10                  15      


His Ala Ala Arg Pro Asn Phe Met Leu Thr Gln Pro His Ser Val Ser 
            20                  25                  30          


Glu Ser Leu Gly Lys Thr Val Thr Ile Ser Cys Thr Gly Ser Ser Gly 
        35                  40                  45              


Ser Ile Ala Arg Lys Phe Val Gln Trp Tyr Gln Gln Arg Pro Gly Ser 
    50                  55                  60                  


Ser Pro Thr Thr Val Ile Tyr Glu Asn Asn Gln Arg Pro Ser Gly Val 
65                  70                  75                  80  


Ser Asp Arg Phe Ser Gly Ser Ile Gly Ser Ser Ser Asn Ser Ala Ser 
                85                  90                  95      


Leu Thr Ile Ser Gly Leu Lys Thr Glu Asp Glu Ala Asp Tyr Tyr Cys 
            100                 105                 110         


Gln Ser Tyr Asp Ser Ser Asn Val Val Phe Gly Gly Gly Thr Lys Val 
        115                 120                 125             


Thr Val Leu Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser Gly Gly Gly 
    130                 135                 140                 


Gly Ser Gly Gly Gly Gly Ser Gln Val Gln Leu Gln Glu Ser Gly Gly 
145                 150                 155                 160 


Gly Leu Val Lys Pro Gly Gly Ser Leu Arg Leu Ser Cys Ala Ala Ser 
                165                 170                 175     


Gly Phe Thr Phe Ser Ser Tyr Ser Met Asn Trp Val Arg Gln Ala Pro 
            180                 185                 190         


Gly Lys Gly Leu Glu Trp Val Ser Gly Ile Asn Thr Ala Gly Asp Thr 
        195                 200                 205             


His Tyr Pro Glu Ser Val Lys Gly Arg Phe Thr Ile Ser Arg Asp Asn 
    210                 215                 220                 


Ala Arg Asn Ser Leu Asn Leu Gln Met Asn Ser Leu Arg Ala Glu Asp 
225                 230                 235                 240 


Thr Ala Val Tyr Tyr Cys Val Arg Glu Arg Val Glu Arg Glu Tyr Ser 
                245                 250                 255     


Gly Tyr Asp Ala Phe Asp Ile Trp Gly Gln Gly Thr Thr Val Thr Val 
            260                 265                 270         


Ser Ala Pro Leu Pro Pro Glu Met Ser Gly Thr Met Leu Met Leu Ala 
        275                 280                 285             


Val Leu Leu Pro Leu Ala Phe Phe Leu Leu Leu Ala Thr Val Phe Ser 
    290                 295                 300                 


Cys Ile Trp Lys Ser His Pro Ser Leu Cys Arg Lys Leu Gly Ser Leu 
305                 310                 315                 320 


Leu Lys Arg Arg Pro Gln Gly Glu Gly Pro Asn Pro Val Ala Gly Ser 
                325                 330                 335     


Trp Glu Pro Pro Lys Ala His Pro Tyr Phe Pro Asp Leu Val Gln Pro 
            340                 345                 350         


Leu Leu Pro Ile Ser Gly Asp Val Ser Pro Val Ser Thr Gly Leu Pro 
        355                 360                 365             


Ala Ala Pro Val Leu Glu Ala Gly Val Pro Gln Gln Gln Ser Pro Leu 
    370                 375                 380                 


Asp Leu Thr Arg Glu Pro Gln Leu Glu Pro Gly Glu Gln Ser Gln Val 
385                 390                 395                 400 


Ala His Gly Thr Asn Gly Ile His Val Thr Gly Gly Ser Met Thr Ile 
                405                 410                 415     


Thr Gly Asn Ile Tyr Ile Tyr Asn Gly Pro Val Leu Gly Gly Pro Pro 
            420                 425                 430         


Gly Pro Gly Asp Leu Pro Ala Thr Pro Glu Pro Pro Tyr Pro Ile Pro 
        435                 440                 445             


Glu Glu Gly Asp Pro Gly Pro Pro Gly Leu Ser Thr Pro His Gln Glu 
    450                 455                 460                 


Asp Gly Lys Ala Trp His Leu Ala Glu Thr Glu His Cys Gly Ala Thr 
465                 470                 475                 480 


Pro Ser Asn Arg Gly Pro Arg Asn Gln Phe Ile Thr His Asp 
                485                 490                 


<210>  714
<211>  386
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic amino acid

<400>  714

Met Ala Leu Pro Val Thr Ala Leu Leu Leu Pro Leu Ala Leu Leu Leu 
1               5                   10                  15      


His Ala Ala Arg Pro Asn Phe Met Leu Thr Gln Pro His Ser Val Ser 
            20                  25                  30          


Glu Ser Leu Gly Lys Thr Val Thr Ile Ser Cys Thr Gly Ser Ser Gly 
        35                  40                  45              


Ser Ile Ala Arg Lys Phe Val Gln Trp Tyr Gln Gln Arg Pro Gly Ser 
    50                  55                  60                  


Ser Pro Thr Thr Val Ile Tyr Glu Asn Asn Gln Arg Pro Ser Gly Val 
65                  70                  75                  80  


Ser Asp Arg Phe Ser Gly Ser Ile Gly Ser Ser Ser Asn Ser Ala Ser 
                85                  90                  95      


Leu Thr Ile Ser Gly Leu Lys Thr Glu Asp Glu Ala Asp Tyr Tyr Cys 
            100                 105                 110         


Gln Ser Tyr Asp Ser Ser Asn Val Val Phe Gly Gly Gly Thr Lys Val 
        115                 120                 125             


Thr Val Leu Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser Gly Gly Gly 
    130                 135                 140                 


Gly Ser Gly Gly Gly Gly Ser Gln Val Gln Leu Gln Glu Ser Gly Gly 
145                 150                 155                 160 


Gly Leu Val Lys Pro Gly Gly Ser Leu Arg Leu Ser Cys Ala Ala Ser 
                165                 170                 175     


Gly Phe Thr Phe Ser Ser Tyr Ser Met Asn Trp Val Arg Gln Ala Pro 
            180                 185                 190         


Gly Lys Gly Leu Glu Trp Val Ser Gly Ile Asn Thr Ala Gly Asp Thr 
        195                 200                 205             


His Tyr Pro Glu Ser Val Lys Gly Arg Phe Thr Ile Ser Arg Asp Asn 
    210                 215                 220                 


Ala Arg Asn Ser Leu Asn Leu Gln Met Asn Ser Leu Arg Ala Glu Asp 
225                 230                 235                 240 


Thr Ala Val Tyr Tyr Cys Val Arg Glu Arg Val Glu Arg Glu Tyr Ser 
                245                 250                 255     


Gly Tyr Asp Ala Phe Asp Ile Trp Gly Gln Gly Thr Thr Val Thr Val 
            260                 265                 270         


Ser Ala Lys Pro Thr Thr Thr Pro Ala Pro Arg Pro Pro Thr Pro Ala 
        275                 280                 285             


Pro Thr Ile Ala Ser Gln Pro Leu Ser Leu Arg Pro Glu Ala Cys Arg 
    290                 295                 300                 


Pro Ala Ala Gly Gly Ala Val His Thr Arg Gly Leu Asp Phe Ala Cys 
305                 310                 315                 320 


Asp Ile Tyr Ile Trp Ala Pro Leu Ala Gly Thr Cys Gly Val Leu Leu 
                325                 330                 335     


Leu Ser Leu Val Ile Thr Leu Tyr Lys Arg Gly Arg Lys Lys Leu Leu 
            340                 345                 350         


Tyr Ile Phe Lys Gln Pro Phe Met Arg Pro Val Gln Thr Thr Gln Glu 
        355                 360                 365             


Glu Asp Gly Cys Ser Cys Arg Phe Pro Glu Glu Glu Glu Gly Gly Cys 
    370                 375                 380                 


Glu Leu 
385     


<210>  715
<211>  531
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic amino acid

<400>  715

Met Ala Leu Pro Val Thr Ala Leu Leu Leu Pro Leu Ala Leu Leu Leu 
1               5                   10                  15      


His Ala Ala Arg Pro Asn Phe Met Leu Thr Gln Pro His Ser Val Ser 
            20                  25                  30          


Glu Ser Leu Gly Lys Thr Val Thr Ile Ser Cys Thr Gly Ser Ser Gly 
        35                  40                  45              


Ser Ile Ala Arg Lys Phe Val Gln Trp Tyr Gln Gln Arg Pro Gly Ser 
    50                  55                  60                  


Ser Pro Thr Thr Val Ile Tyr Glu Asn Asn Gln Arg Pro Ser Gly Val 
65                  70                  75                  80  


Ser Asp Arg Phe Ser Gly Ser Ile Gly Ser Ser Ser Asn Ser Ala Ser 
                85                  90                  95      


Leu Thr Ile Ser Gly Leu Lys Thr Glu Asp Glu Ala Asp Tyr Tyr Cys 
            100                 105                 110         


Gln Ser Tyr Asp Ser Ser Asn Val Val Phe Gly Gly Gly Thr Lys Val 
        115                 120                 125             


Thr Val Leu Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser Gly Gly Gly 
    130                 135                 140                 


Gly Ser Gly Gly Gly Gly Ser Gln Val Gln Leu Gln Glu Ser Gly Gly 
145                 150                 155                 160 


Gly Leu Val Lys Pro Gly Gly Ser Leu Arg Leu Ser Cys Ala Ala Ser 
                165                 170                 175     


Gly Phe Thr Phe Ser Ser Tyr Ser Met Asn Trp Val Arg Gln Ala Pro 
            180                 185                 190         


Gly Lys Gly Leu Glu Trp Val Ser Gly Ile Asn Thr Ala Gly Asp Thr 
        195                 200                 205             


His Tyr Pro Glu Ser Val Lys Gly Arg Phe Thr Ile Ser Arg Asp Asn 
    210                 215                 220                 


Ala Arg Asn Ser Leu Asn Leu Gln Met Asn Ser Leu Arg Ala Glu Asp 
225                 230                 235                 240 


Thr Ala Val Tyr Tyr Cys Val Arg Glu Arg Val Glu Arg Glu Tyr Ser 
                245                 250                 255     


Gly Tyr Asp Ala Phe Asp Ile Trp Gly Gln Gly Thr Thr Val Thr Val 
            260                 265                 270         


Ser Ala Lys Pro Thr Thr Thr Pro Ala Pro Arg Pro Pro Thr Pro Ala 
        275                 280                 285             


Pro Thr Ile Ala Ser Gln Pro Leu Ser Leu Arg Pro Glu Ala Cys Arg 
    290                 295                 300                 


Pro Ala Ala Gly Gly Ala Val His Thr Arg Gly Leu Asp Phe Ala Cys 
305                 310                 315                 320 


Asp Ile Tyr Ile Trp Ala Pro Leu Ala Gly Thr Cys Gly Val Leu Leu 
                325                 330                 335     


Leu Ser Leu Val Ile Thr Leu Tyr Lys Ser His Pro Ser Leu Cys Arg 
            340                 345                 350         


Lys Leu Gly Ser Leu Leu Lys Arg Arg Pro Gln Gly Glu Gly Pro Asn 
        355                 360                 365             


Pro Val Ala Gly Ser Trp Glu Pro Pro Lys Ala His Pro Tyr Phe Pro 
    370                 375                 380                 


Asp Leu Val Gln Pro Leu Leu Pro Ile Ser Gly Asp Val Ser Pro Val 
385                 390                 395                 400 


Ser Thr Gly Leu Pro Ala Ala Pro Val Leu Glu Ala Gly Val Pro Gln 
                405                 410                 415     


Gln Gln Ser Pro Leu Asp Leu Thr Arg Glu Pro Gln Leu Glu Pro Gly 
            420                 425                 430         


Glu Gln Ser Gln Val Ala His Gly Thr Asn Gly Ile His Val Thr Gly 
        435                 440                 445             


Gly Ser Met Thr Ile Thr Gly Asn Ile Tyr Ile Tyr Asn Gly Pro Val 
    450                 455                 460                 


Leu Gly Gly Pro Pro Gly Pro Gly Asp Leu Pro Ala Thr Pro Glu Pro 
465                 470                 475                 480 


Pro Tyr Pro Ile Pro Glu Glu Gly Asp Pro Gly Pro Pro Gly Leu Ser 
                485                 490                 495     


Thr Pro His Gln Glu Asp Gly Lys Ala Trp His Leu Ala Glu Thr Glu 
            500                 505                 510         


His Cys Gly Ala Thr Pro Ser Asn Arg Gly Pro Arg Asn Gln Phe Ile 
        515                 520                 525             


Thr His Asp 
    530     


<210>  716
<211>  573
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic amino acid

<400>  716

Met Ala Leu Pro Val Thr Ala Leu Leu Leu Pro Leu Ala Leu Leu Leu 
1               5                   10                  15      


His Ala Ala Arg Pro Asn Phe Met Leu Thr Gln Pro His Ser Val Ser 
            20                  25                  30          


Glu Ser Leu Gly Lys Thr Val Thr Ile Ser Cys Thr Gly Ser Ser Gly 
        35                  40                  45              


Ser Ile Ala Arg Lys Phe Val Gln Trp Tyr Gln Gln Arg Pro Gly Ser 
    50                  55                  60                  


Ser Pro Thr Thr Val Ile Tyr Glu Asn Asn Gln Arg Pro Ser Gly Val 
65                  70                  75                  80  


Ser Asp Arg Phe Ser Gly Ser Ile Gly Ser Ser Ser Asn Ser Ala Ser 
                85                  90                  95      


Leu Thr Ile Ser Gly Leu Lys Thr Glu Asp Glu Ala Asp Tyr Tyr Cys 
            100                 105                 110         


Gln Ser Tyr Asp Ser Ser Asn Val Val Phe Gly Gly Gly Thr Lys Val 
        115                 120                 125             


Thr Val Leu Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser Gly Gly Gly 
    130                 135                 140                 


Gly Ser Gly Gly Gly Gly Ser Gln Val Gln Leu Gln Glu Ser Gly Gly 
145                 150                 155                 160 


Gly Leu Val Lys Pro Gly Gly Ser Leu Arg Leu Ser Cys Ala Ala Ser 
                165                 170                 175     


Gly Phe Thr Phe Ser Ser Tyr Ser Met Asn Trp Val Arg Gln Ala Pro 
            180                 185                 190         


Gly Lys Gly Leu Glu Trp Val Ser Gly Ile Asn Thr Ala Gly Asp Thr 
        195                 200                 205             


His Tyr Pro Glu Ser Val Lys Gly Arg Phe Thr Ile Ser Arg Asp Asn 
    210                 215                 220                 


Ala Arg Asn Ser Leu Asn Leu Gln Met Asn Ser Leu Arg Ala Glu Asp 
225                 230                 235                 240 


Thr Ala Val Tyr Tyr Cys Val Arg Glu Arg Val Glu Arg Glu Tyr Ser 
                245                 250                 255     


Gly Tyr Asp Ala Phe Asp Ile Trp Gly Gln Gly Thr Thr Val Thr Val 
            260                 265                 270         


Ser Ala Lys Pro Thr Thr Thr Pro Ala Pro Arg Pro Pro Thr Pro Ala 
        275                 280                 285             


Pro Thr Ile Ala Ser Gln Pro Leu Ser Leu Arg Pro Glu Ala Cys Arg 
    290                 295                 300                 


Pro Ala Ala Gly Gly Ala Val His Thr Arg Gly Leu Asp Phe Ala Cys 
305                 310                 315                 320 


Asp Ile Tyr Ile Trp Ala Pro Leu Ala Gly Thr Cys Gly Val Leu Leu 
                325                 330                 335     


Leu Ser Leu Val Ile Thr Leu Tyr Lys Ser His Pro Ser Leu Cys Arg 
            340                 345                 350         


Lys Leu Gly Ser Leu Leu Lys Arg Arg Pro Gln Gly Glu Gly Pro Asn 
        355                 360                 365             


Pro Val Ala Gly Ser Trp Glu Pro Pro Lys Ala His Pro Tyr Phe Pro 
    370                 375                 380                 


Asp Leu Val Gln Pro Leu Leu Pro Ile Ser Gly Asp Val Ser Pro Val 
385                 390                 395                 400 


Ser Thr Gly Leu Pro Ala Ala Pro Val Leu Glu Ala Gly Val Pro Gln 
                405                 410                 415     


Gln Gln Ser Pro Leu Asp Leu Thr Arg Glu Pro Gln Leu Glu Pro Gly 
            420                 425                 430         


Glu Gln Ser Gln Val Ala His Gly Thr Asn Gly Ile His Val Thr Gly 
        435                 440                 445             


Gly Ser Met Thr Ile Thr Gly Asn Ile Tyr Ile Tyr Asn Gly Pro Val 
    450                 455                 460                 


Leu Gly Gly Pro Pro Gly Pro Gly Asp Leu Pro Ala Thr Pro Glu Pro 
465                 470                 475                 480 


Pro Tyr Pro Ile Pro Glu Glu Gly Asp Pro Gly Pro Pro Gly Leu Ser 
                485                 490                 495     


Thr Pro His Gln Glu Asp Gly Lys Ala Trp His Leu Ala Glu Thr Glu 
            500                 505                 510         


His Cys Gly Ala Thr Pro Ser Asn Arg Gly Pro Arg Asn Gln Phe Ile 
        515                 520                 525             


Thr His Asp Lys Arg Gly Arg Lys Lys Leu Leu Tyr Ile Phe Lys Gln 
    530                 535                 540                 


Pro Phe Met Arg Pro Val Gln Thr Thr Gln Glu Glu Asp Gly Cys Ser 
545                 550                 555                 560 


Cys Arg Phe Pro Glu Glu Glu Glu Gly Gly Cys Glu Leu 
                565                 570             


<210>  717
<211>  573
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic amino acid

<400>  717

Met Ala Leu Pro Val Thr Ala Leu Leu Leu Pro Leu Ala Leu Leu Leu 
1               5                   10                  15      


His Ala Ala Arg Pro Asn Phe Met Leu Thr Gln Pro His Ser Val Ser 
            20                  25                  30          


Glu Ser Leu Gly Lys Thr Val Thr Ile Ser Cys Thr Gly Ser Ser Gly 
        35                  40                  45              


Ser Ile Ala Arg Lys Phe Val Gln Trp Tyr Gln Gln Arg Pro Gly Ser 
    50                  55                  60                  


Ser Pro Thr Thr Val Ile Tyr Glu Asn Asn Gln Arg Pro Ser Gly Val 
65                  70                  75                  80  


Ser Asp Arg Phe Ser Gly Ser Ile Gly Ser Ser Ser Asn Ser Ala Ser 
                85                  90                  95      


Leu Thr Ile Ser Gly Leu Lys Thr Glu Asp Glu Ala Asp Tyr Tyr Cys 
            100                 105                 110         


Gln Ser Tyr Asp Ser Ser Asn Val Val Phe Gly Gly Gly Thr Lys Val 
        115                 120                 125             


Thr Val Leu Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser Gly Gly Gly 
    130                 135                 140                 


Gly Ser Gly Gly Gly Gly Ser Gln Val Gln Leu Gln Glu Ser Gly Gly 
145                 150                 155                 160 


Gly Leu Val Lys Pro Gly Gly Ser Leu Arg Leu Ser Cys Ala Ala Ser 
                165                 170                 175     


Gly Phe Thr Phe Ser Ser Tyr Ser Met Asn Trp Val Arg Gln Ala Pro 
            180                 185                 190         


Gly Lys Gly Leu Glu Trp Val Ser Gly Ile Asn Thr Ala Gly Asp Thr 
        195                 200                 205             


His Tyr Pro Glu Ser Val Lys Gly Arg Phe Thr Ile Ser Arg Asp Asn 
    210                 215                 220                 


Ala Arg Asn Ser Leu Asn Leu Gln Met Asn Ser Leu Arg Ala Glu Asp 
225                 230                 235                 240 


Thr Ala Val Tyr Tyr Cys Val Arg Glu Arg Val Glu Arg Glu Tyr Ser 
                245                 250                 255     


Gly Tyr Asp Ala Phe Asp Ile Trp Gly Gln Gly Thr Thr Val Thr Val 
            260                 265                 270         


Ser Ala Lys Pro Thr Thr Thr Pro Ala Pro Arg Pro Pro Thr Pro Ala 
        275                 280                 285             


Pro Thr Ile Ala Ser Gln Pro Leu Ser Leu Arg Pro Glu Ala Cys Arg 
    290                 295                 300                 


Pro Ala Ala Gly Gly Ala Val His Thr Arg Gly Leu Asp Phe Ala Cys 
305                 310                 315                 320 


Asp Ile Tyr Ile Trp Ala Pro Leu Ala Gly Thr Cys Gly Val Leu Leu 
                325                 330                 335     


Leu Ser Leu Val Ile Thr Leu Tyr Lys Arg Gly Arg Lys Lys Leu Leu 
            340                 345                 350         


Tyr Ile Phe Lys Gln Pro Phe Met Arg Pro Val Gln Thr Thr Gln Glu 
        355                 360                 365             


Glu Asp Gly Cys Ser Cys Arg Phe Pro Glu Glu Glu Glu Gly Gly Cys 
    370                 375                 380                 


Glu Leu Lys Ser His Pro Ser Leu Cys Arg Lys Leu Gly Ser Leu Leu 
385                 390                 395                 400 


Lys Arg Arg Pro Gln Gly Glu Gly Pro Asn Pro Val Ala Gly Ser Trp 
                405                 410                 415     


Glu Pro Pro Lys Ala His Pro Tyr Phe Pro Asp Leu Val Gln Pro Leu 
            420                 425                 430         


Leu Pro Ile Ser Gly Asp Val Ser Pro Val Ser Thr Gly Leu Pro Ala 
        435                 440                 445             


Ala Pro Val Leu Glu Ala Gly Val Pro Gln Gln Gln Ser Pro Leu Asp 
    450                 455                 460                 


Leu Thr Arg Glu Pro Gln Leu Glu Pro Gly Glu Gln Ser Gln Val Ala 
465                 470                 475                 480 


His Gly Thr Asn Gly Ile His Val Thr Gly Gly Ser Met Thr Ile Thr 
                485                 490                 495     


Gly Asn Ile Tyr Ile Tyr Asn Gly Pro Val Leu Gly Gly Pro Pro Gly 
            500                 505                 510         


Pro Gly Asp Leu Pro Ala Thr Pro Glu Pro Pro Tyr Pro Ile Pro Glu 
        515                 520                 525             


Glu Gly Asp Pro Gly Pro Pro Gly Leu Ser Thr Pro His Gln Glu Asp 
    530                 535                 540                 


Gly Lys Ala Trp His Leu Ala Glu Thr Glu His Cys Gly Ala Thr Pro 
545                 550                 555                 560 


Ser Asn Arg Gly Pro Arg Asn Gln Phe Ile Thr His Asp 
                565                 570             


<210>  718
<211>  1065
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Synthetic nucleotide

<400>  718
atggcgcttc cggtgactgc tcttctcttg cccctggctc tgctgctgca cgctgcccgg       60

cccaacttca tgttgaccca gccgcactcc gtgtcggaga gcctgggcaa gactgtcacg      120

atctcatgca ctggatcttc tgggtccatt gctcgcaaat ttgtgcagtg gtaccagcag      180

cgtcccgggt ctagtccgac aaccgtgatc tacgagaaca accagagacc atcgggcgtg      240

tccgacaggt tttcgggatc tatcggtagc tcctccaact ccgcttccct caccatttct      300

ggtctcaaga ccgaggacga ggctgattat tactgccaga gctacgacag cagcaacgtg      360

gtgttcggtg gcggcaccaa ggtcactgtg ctgggtggag gaggctctgg cggcggaggg      420

tccggtggcg gcggctcggg gggcggcggt tcgcaggtcc agctgcagga gagcggtggg      480

gggctggtga agcctggtgg ttccctacgg ctgtcttgtg ccgcatctgg cttcacgttc      540

tcaagctatt cgatgaattg ggtgcgccag gcccccggca aaggactgga gtgggtctcc      600

ggcattaaca cggcaggtga tacgcattac cccgagagcg tgaaaggccg cttcaccatc      660

tcccgcgaca acgcgcgcaa ctccctcaac ctgcagatga acagccttcg cgccgaggac      720

accgccgtgt actactgcgt gagggagcgc gtggagcgcg agtactccgg ctatgacgcc      780

ttcgacatct ggggccaggg caccacagtc accgtatctg cgccggcccc tgcccgagag      840

ccaggccact cccctcagat catctccttc ttcctggcct taacctccac cgcgttgctg      900

tttctgctct ttttcctgac cctgcgcttc agcgttgtta agcgcggccg caagaagctg      960

ctgtacatct tcaagcaacc cttcatgcgt cccgtgcaga ctacccagga ggaagatggg     1020

tgcagttgtc gttttcctga agaagaggag ggcgggtgcg agctg                     1065


<210>  719
<211>  1485
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Synthetic nucleotide

<400>  719
atggctctgc ccgtcactgc cctccttctt ccgctcgcgc tgctgctgca cgctgctcgg       60

cccaacttta tgctaaccca gccgcacagc gtctccgaga gcctgggcaa aaccgtgacc      120

atctcatgca ctggatcgag tgggtccatc gcacgtaaat ttgtgcagtg gtaccagcag      180

aggcccggca gctcgccaac cacagtgatt tacgagaaca accagcgtcc gtccggggtt      240

tctgatcgtt tctcgggctc tatcggctcc tcgagcaact ccgcctccct gacgatcagc      300

ggactcaaga ccgaggacga ggcagactat tactgccaga gctacgactc ttcaaatgtg      360

gtgttcggag gaggcaccaa ggtgactgtc ttgggtggtg ggggctccgg cggcggcggc      420

tctggaggcg gcggctctgg cggcggtggc tcccaggtcc agctgcagga gagcggtggg      480

gggctggtga agcctggcgg ctcgttgcgc ctgtcatgcg ccgcttctgg cttcacgttt      540

tcttcgtact ccatgaattg ggtgcgccag gcccctggta aaggtctgga gtgggtcagt      600

ggaattaaca cggccggcga cacccactac cctgagtctg taaagggtcg cttcaccatc      660

tctcgcgaca acgccagaaa ttccctcaac ctgcagatga actccctgcg cgcagaggat      720

actgccgtgt actactgcgt gagggagcgc gtggagcggg agtactccgg ctacgacgcc      780

ttcgacatct ggggccaagg caccaccgtg actgtttccg cccccctgcc tcccgagatg      840

tccgggacga tgctgatgct ggctgtgctg ctgccgctag cgttcttcct gttgctggcg      900

actgtcttta gctgtatttg gaagtcccac cccagtttgt gccgaaagct gggctccctg      960

ctgaagcgcc gccctcaggg ggagggccca aatccagtgg cgggcagttg ggagccccca     1020

aaggcccatc cctatttccc cgacctggtg cagccgttac tgcccatctc cggggacgtg     1080

tccccagttt cgaccggtct ccctgccgca cctgtcctgg aggccggcgt gcctcaacag     1140

cagagccctt tggacctgac ccgcgaacct cagcttgagc caggggaaca gtcacaggta     1200

gcgcatggaa ccaacggcat ccacgtcacc ggaggttcta tgaccattac aggcaacatc     1260

tacatataca acggtccggt gctaggaggt ccgccagggc cgggtgatct ccccgccacc     1320

ccagaacccc cctatcccat cccggaggag ggcgacccgg gcccccccgg gctgtccacc     1380

ccccaccagg aagacggcaa ggcgtggcac ttagccgaga ctgagcactg tggcgccaca     1440

ccttctaacc gcggcccgcg caaccagttc atcacccatg actaa                     1485


<210>  720
<211>  1158
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Synthetic nucleotide

<400>  720
atggccttgc cggtgactgc actcctgctg cctctggcgc tgctcttaca cgccgcacgt       60

cccaacttta tgctgaccca gccgcattcc gtgtcggaga gcctgggcaa aactgtgacc      120

atctcgtgta cggggtcgtc cgggagcatc gctcgcaaat ttgtgcagtg gtaccagcag      180

cgtccgggct cttcccccac cacagtaatt tacgagaaca accagcggcc ctctggcgtt      240

agtgacaggt tttcaggctc tatcggcagc agcagcaact ccgcctccct aactatctct      300

ggtctgaaga ccgaggacga ggcggactat tactgtcaga gctatgattc ttccaatgtg      360

gtgttcggag gagggactaa ggtgacggtg ctgggtggtg gtgggagcgg aggtggcgga      420

tccggcgggg gtggctccgg tggaggcggc tcccaggtcc agttgcagga gagcggcggt      480

ggcctggtga agcccggcgg ctcgttgcgc ctgtcctgtg ctgcttctgg cttcacattc      540

agttcgtact ccatgaactg ggtccgccag gcccccggaa aaggcctgga gtgggtgtcc      600

ggcattaaca cggccgggga cacccactac cctgaatctg tcaagggccg cttcaccatt      660

tcccgcgaca acgcgaggaa ctccctcaac ctgcagatga actccctgcg cgccgaggat      720

accgccgtgt actactgcgt gcgagaacgc gtggagcgcg agtactcagg ctacgacgca      780

ttcgacatat ggggccaggg caccaccgtc accgtgtccg ccaagccaac tacaaccccc      840

gccccgagac ccccaacccc tgcgccaacc atcgcttccc aacccctgtc tctgcggcct      900

gaggcctgcc gaccagcggc tggcggtgct gtccacactc gcggtttgga tttcgcttgc      960

gacatctaca tctgggcgcc tctcgccggc acctgcgggg ttcttctgct gagccttgtc     1020

atcacccttt acaagcgcgg acgcaagaag ctgctttata tcttcaagca gcccttcatg     1080

cgtcctgtgc agacgaccca ggaggaggac ggctgttcat gccgtttccc ggaagaggag     1140

gagggcgggt gcgagctg                                                   1158


<210>  721
<211>  1593
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Synthetic nucleotide

<400>  721
atggcactgc ctgtgacggc tctgttgctg ccgctcgctc ttctgctaca cgccgctcgc       60

cccaacttta tgctcaccca gcctcattcc gtgtcggagt cattaggaaa aaccgtaaca      120

atctcttgca ctggctcatc tggttccatt gcacgcaaat ttgtgcagtg gtaccagcag      180

cggccaggta gcagcccaac cactgtcatc tacgagaaca accagcgtcc ttcgggggtg      240

agcgacaggt tctcgggttc tatcggctcg tcctccaact ccgcttccct gacaattagc      300

gggctgaaga ctgaggacga ggcggactac tactgtcaga gctacgattc ttccaacgtg      360

gtgttcggcg ggggcaccaa ggtgactgtg ctgggaggag gcggatctgg tggcggcggt      420

agcggtgggg gcggttcagg cggtggcggc tcccaggtgc agctgcagga gtctggcgga      480

ggcctcgtga agcccggtgg ttctctgaga ttgagttgtg ccgcgtcggg cttcaccttt      540

agctcttact ccatgaattg ggtccgccag gctcccggca agggccttga gtgggtgagc      600

ggcattaata cggccgggga tacccactac cctgagagcg ttaaaggccg cttcaccatc      660

tcgcgagaca acgcgcgcaa ctccctcaac ctgcagatga actctctgcg cgctgaagac      720

accgccgtgt actactgcgt gagggagcgg gtggagcgtg agtactccgg ctacgacgcc      780

ttcgacatat ggggccaagg caccaccgtc actgtctccg ccaagcccac caccactccc      840

gcgccacgcc cgcctacacc cgcccccacg atcgcctctc agccgctgag cctccggccg      900

gaggcctgcc gtccggccgc aggcggagcc gtgcacacac gcggcttgga cttcgcatgc      960

gacatttaca tctgggcccc cctggccggc acctgcgggg tgctgcttct ttcgctggtg     1020

atcaccctgt acaagagcca cccttctctg tgccgcaagc tgggctccct gttaaagcgc     1080

cgtcctcagg gcgagggccc caatccagtg gctgggagtt gggaaccccc caaggcgcac     1140

ccctatttcc ccgacctggt ccagcccctc ctgcccatct ccggagacgt gtccccggta     1200

tccaccggtc tgcctgctgc tccggtcctg gaggccggcg tgccgcaaca gcagagccct     1260

cttgacctga cccgcgagcc acagctcgag cccggggaac agtcccaggt cgcgcatgga     1320

accaacggca tccacgttac cggaggtagt atgactatca ccggcaacat ctatatttac     1380

aatggcccag ttttgggtgg gccccctggc cctggggatc tcccagcgac gcccgaaccg     1440

ccctatccga tcccggagga gggcgatcca ggaccccccg gcctgtccac ccctcaccag     1500

gaggacggca aggcctggca cctggccgag accgagcact gtggggccac gccgtccaac     1560

cgcggtcccc gcaaccagtt catcactcat gac                                  1593


<210>  722
<211>  1719
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Synthetic nucleotide

<400>  722
atggccctgc ccgtcacagc acttctcctt cccctggcgc tcctgctaca cgccgctcgc       60

cccaacttta tgctcaccca gcctcattct gtttccgaga gtttgggcaa aaccgtcacc      120

atttcctgca ctggttcctc cggatctatc gcgcgcaaat ttgtccagtg gtaccagcag      180

agaccgggct ccagccctac caccgtgatt tacgagaaca accagaggcc ctccggtgtg      240

agcgatcggt tttccggttc catcggttcg agttcgaata gcgcatccct gactatctca      300

gggctgaaga ctgaagacga ggcggactat tactgccaaa gctacgattc ttccaacgtg      360

gtgttcggcg gcgggaccaa ggtgaccgtg ttgggcggcg gaggatctgg aggcggcggt      420

tctgggggtg ggggcagcgg cggtgggggc tcccaggtgc agttgcagga gagcgggggc      480

gggcttgtga agcccggcgg ctcgctgcgc ctgtcatgtg ctgcttccgg cttcacattc      540

tcgagttact ccatgaactg ggtgcgacag gccccaggca agggcctaga gtgggtcagc      600

ggaattaaca cggccggcga cacacactac cccgagagcg ttaagggacg cttcaccatc      660

tctcgtgaca acgctcgcaa ctccctcaac ctgcagatga actccctgcg agcagaggac      720

accgccgtgt actactgcgt gcgggagcgc gtggagcgtg agtacagcgg atacgacgcc      780

ttcgacatat ggggccaggg cacaaccgtt accgtgtccg ccaagcctac gaccactccc      840

gctccgcggc cgcctacccc tgccccaacc atcgccagcc agccactttc gctgagacca      900

gaagcgtgcc gtccggccgc aggtggcgct gtccacactc gcggcctcga ctttgcctgc      960

gacatctaca tttgggcgcc tttggctggc acctgcgggg tgctgctgct gagcctggtg     1020

atcaccctgt acaagagtca cccctctctg tgccgcaaac tgggctccct gctcaagcgc     1080

cgcccgcaag gcgagggccc caatccagtg gctggcagtt gggagccacc caaggctcac     1140

ccctatttcc ccgacctggt gcagccactg ctgcctatct ccggtgatgt atctccggtg     1200

tctacaggtt tgcctgctgc ccctgtctta gaggccggcg tccctcagca gcagagcccc     1260

ttggatctga ccagggagcc ccagcttgag ccaggggaac agtcacaggt cgcgcatgga     1320

accaacggca tccacgtaac cggcggatct atgacgatta ccggcaacat ctatatctac     1380

aacggacccg tgctgggtgg gcccccggga cccggggacc tgccggccac ccccgaacca     1440

ccctatccca tccctgagga gggcgacccg ggtcccccgg gcctatccac ccctcaccag     1500

gaggatggca aggcgtggca cctggctgag accgagcact gtggcgccac gccatcgaac     1560

cgcggcccgc gcaaccagtt catcactcat gacaaacgtg gcaggaagaa gctgctgtac     1620

atcttcaagc agccgttcat gcgccctgtg cagacgaccc aggaggagga cgggtgttct     1680

tgtcgcttcc cggaggagga agagggcggg tgcgagctg                            1719


<210>  723
<211>  1719
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Synthetic nucleotide

<400>  723
atggccctgc ccgtcacggc cttactcctg ccactggcgc tgctgttgca cgccgcgcgc       60

cctaacttta tgctgaccca gcctcatagc gtgtccgaga gcctgggtaa aacggtcacc      120

atcagttgca ctggctcgtc tggaagcatc gcccgcaaat ttgtgcagtg gtaccagcag      180

cgcccgggca gctcgccgac cacagttatt tacgagaaca accagaggcc ctccggcgtc      240

tccgacaggt tttcaggctc catcggtagc tcctcaaatt ccgcttccct aactatctct      300

ggcctgaaga ctgaagacga ggcggactat tactgccaga gttacgattc ttccaacgtg      360

gtgttcggag gtggcaccaa ggtgaccgtg ctcgggggcg gtggctcggg cgggggcggt      420

tccggtggcg gcggctctgg tggggggggc agccaggtcc aattgcagga gagtgggggt      480

ggcctggtca agcccggcgg ctccctccgc ctgtcttgcg ctgcttctgg cttcacgttc      540

tcgtcctact ctatgaattg ggtccgccag gccccgggca aaggcctcga gtgggtgtcc      600

ggaattaaca cggccgggga cacccactac cccgagtccg taaaggggcg attcaccata      660

tcacgcgaca acgctcgcaa cagcctcaac ctgcagatga actctctgcg tgccgaggac      720

accgccgtgt actactgcgt gcgcgagcgc gtggagcggg agtactccgg ctacgacgcc      780

ttcgacattt ggggccaggg aactaccgtc acagtcagcg ccaagcctac cacaaccccc      840

gcgcctcggc ccccgactcc tgctcccacc atcgctagcc agccactgtc cctgcgcccc      900

gaggcatgcc gaccagcagc aggcggcgcc gtgcacacaa gaggattgga ttttgcttgc      960

gacatctaca tctgggcccc gctggcgggc acctgcgggg tgctactgct ctcgctggtg     1020

attaccctgt acaagcgtgg ccgcaagaag ctgctttaca tcttcaagca gcccttcatg     1080

cgccctgtgc agacgaccca ggaggaggat ggatgttctt gtcgtttccc tgaagaagag     1140

gagggcgggt gcgagttgaa atcccacccc tcgctgtgcc gcaagctggg tagcctccta     1200

aagcgtcgcc ctcagggcga gggccctaat ccagtggctg gaagttggga gccacccaag     1260

gcgcacccct atttccccga cttggtgcag cccctgctgc ccatctctgg tgatgtaagc     1320

ccggtttcca ccggccttcc tgcagcgcca gttctggagg ctggcgtgcc acaacagcag     1380

tcgcctctcg acctgactag ggagccccag ctggagccag gggaacagtc acaggtggcg     1440

catggaacca acggcatcca cgtcaccggt ggctccatga ccatcactgg caacatctat     1500

atctacaacg gccccgtgct gggcggccca cctggaccgg gagatctgcc tgccaccccc     1560

gaacccccat atccgatccc ggaggagggt gacccgggac ccccggggct ttccaccccg     1620

caccaggagg acggcaaggc ctggcacttg gccgagaccg agcactgtgg tgctactccc     1680

tctaaccggg gtccccgcaa ccagttcatc acgcatgac                            1719
