                         SEQUENCE LISTING

<110>  JANSSEN BIOTECH, INC.
 
<120>  MOLECULES WITH ENGINEERED ANTIBODY CONSTANT REGION VARIANTS

<130>  14620-683-228

<140>
<141>

<150>  US 63/176,736
<151>  2021-04-19

<150>  US 63/176,731
<151>  2021-04-19

<150>  US 63/176,725
<151>  2021-04-19

<150>  US 63/176,720
<151>  2021-04-19

<150>  US 63/176,718
<151>  2021-04-19

<160>  48    

<170>  PatentIn version 3.5

<210>  1
<211>  103
<212>  PRT
<213>  Homo sapiens

<400>  1

Ala Ser Thr Lys Gly Pro Ser Val Phe Pro Leu Ala Pro Ser Ser Lys 
1               5                   10                  15      


Ser Thr Ser Gly Gly Thr Ala Ala Leu Gly Cys Leu Val Lys Asp Tyr 
            20                  25                  30          


Phe Pro Glu Pro Val Thr Val Ser Trp Asn Ser Gly Ala Leu Thr Ser 
        35                  40                  45              


Gly Val His Thr Phe Pro Ala Val Leu Gln Ser Ser Gly Leu Tyr Ser 
    50                  55                  60                  


Leu Ser Ser Val Val Thr Val Pro Ser Ser Ser Leu Gly Thr Gln Thr 
65                  70                  75                  80  


Tyr Ile Cys Asn Val Asn His Lys Pro Ser Asn Thr Lys Val Asp Lys 
                85                  90                  95      


Lys Val Glu Pro Lys Ser Cys 
            100             


<210>  2
<211>  107
<212>  PRT
<213>  Homo sapiens

<400>  2

Arg Thr Val Ala Ala Pro Ser Val Phe Ile Phe Pro Pro Ser Asp Glu 
1               5                   10                  15      


Gln Leu Lys Ser Gly Thr Ala Ser Val Val Cys Leu Leu Asn Asn Phe 
            20                  25                  30          


Tyr Pro Arg Glu Ala Lys Val Gln Trp Lys Val Asp Asn Ala Leu Gln 
        35                  40                  45              


Ser Gly Asn Ser Gln Glu Ser Val Thr Glu Gln Asp Ser Lys Asp Ser 
    50                  55                  60                  


Thr Tyr Ser Leu Ser Ser Thr Leu Thr Leu Ser Lys Ala Asp Tyr Glu 
65                  70                  75                  80  


Lys His Lys Val Tyr Ala Cys Glu Val Thr His Gln Gly Leu Ser Ser 
                85                  90                  95      


Pro Val Thr Lys Ser Phe Asn Arg Gly Glu Cys 
            100                 105         


<210>  3
<211>  106
<212>  PRT
<213>  Homo sapiens

<400>  3

Gly Gln Pro Lys Ala Asn Pro Thr Val Thr Leu Phe Pro Pro Ser Ser 
1               5                   10                  15      


Glu Glu Leu Gln Ala Asn Lys Ala Thr Leu Val Cys Leu Ile Ser Asp 
            20                  25                  30          


Phe Tyr Pro Gly Ala Val Thr Val Ala Trp Lys Ala Asp Gly Ser Pro 
        35                  40                  45              


Val Lys Ala Gly Val Glu Thr Thr Lys Pro Ser Lys Gln Ser Asn Asn 
    50                  55                  60                  


Lys Tyr Ala Ala Ser Ser Tyr Leu Ser Leu Thr Pro Glu Gln Trp Lys 
65                  70                  75                  80  


Ser His Arg Ser Tyr Ser Cys Gln Val Thr His Glu Gly Ser Thr Val 
                85                  90                  95      


Glu Lys Thr Val Ala Pro Thr Glu Cys Ser 
            100                 105     


<210>  4
<211>  107
<212>  PRT
<213>  Homo sapiens

<400>  4

Arg Thr Val Ala Ala Pro Ser Val Phe Ile Phe Pro Pro Ser Asp Glu 
1               5                   10                  15      


Gln Leu Lys Ser Gly Thr Ala Ser Val Val Cys Leu Leu Asn Asn Phe 
            20                  25                  30          


Tyr Pro Arg Glu Ala Lys Val Gln Trp Lys Val Asp Asn Ala Leu Gln 
        35                  40                  45              


Ser Gly Asn Ser Gln Glu Ser Val Thr Glu Gln Asp Ser Lys Asp Ser 
    50                  55                  60                  


Thr Tyr Ser Leu Ser Ser Thr Leu Thr Leu Ser Lys Ala Asp Tyr Glu 
65                  70                  75                  80  


Lys His Lys Val Tyr Ala Cys Glu Val Thr His Gln Gly Leu Ser Ser 
                85                  90                  95      


Pro Val Thr Lys Ser Phe Asn Arg Gly Glu Cys 
            100                 105         


<210>  5
<211>  103
<212>  PRT
<213>  Homo sapiens

<400>  5

Ala Ser Thr Lys Gly Pro Ser Val Phe Pro Leu Ala Pro Ser Ser Lys 
1               5                   10                  15      


Ser Thr Ser Gly Gly Thr Ala Ala Leu Gly Cys Leu Val Lys Asp Tyr 
            20                  25                  30          


Phe Pro Glu Pro Val Thr Val Ser Trp Asn Ser Gly Ala Leu Thr Ser 
        35                  40                  45              


Gly Val His Thr Phe Pro Ala Val Leu Gln Ser Ser Gly Leu Tyr Ser 
    50                  55                  60                  


Leu Ser Ser Val Val Thr Val Pro Ser Ser Ser Leu Gly Thr Gln Thr 
65                  70                  75                  80  


Tyr Ile Cys Asn Val Asn His Lys Pro Ser Asn Thr Lys Val Asp Lys 
                85                  90                  95      


Lys Val Glu Pro Lys Ser Cys 
            100             


<210>  6
<211>  9
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Description of Artificial Sequence: Synthetic peptide

<400>  6

Ser Arg His His His His His Gly Asp 
1               5                   


<210>  7
<211>  8
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Description of Artificial Sequence: Synthetic peptide

<400>  7

Ser Arg His His His His Gly Asp 
1               5               


<210>  8
<211>  15
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Description of Artificial Sequence: Synthetic peptide

<400>  8

Arg Tyr Arg Ala His His Asn His His Asp Gly His His Ser Ala 
1               5                   10                  15  


<210>  9
<211>  13
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Description of Artificial Sequence: Synthetic peptide

<400>  9

Ala His Gln Thr Asp His His His His His Gln Asp Gly 
1               5                   10              


<210>  10
<211>  11
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Description of Artificial Sequence: Synthetic peptide

<400>  10

Asp Gly Ala His His His His His Ala Ser Arg 
1               5                   10      


<210>  11
<211>  7
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Description of Artificial Sequence: Synthetic peptide

<400>  11

Arg His His Tyr Arg Arg Gly 
1               5           


<210>  12
<211>  9
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Description of Artificial Sequence: Synthetic peptide

<400>  12

Ser Leu His His His His His Gly Asp 
1               5                   


<210>  13
<211>  9
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Description of Artificial Sequence: Synthetic peptide

<400>  13

Ser His His His His His His Gly Asp 
1               5                   


<210>  14
<211>  9
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Description of Artificial Sequence: Synthetic peptide

<400>  14

Ser Arg His His His His His Gly Asn 
1               5                   


<210>  15
<211>  24
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Description of Artificial Sequence: Synthetic peptide

<400>  15

Gly Ala Leu Thr Ala Gly Ala Ala Gly Ala Tyr Gln Ala Tyr Pro Gly 
1               5                   10                  15      


Thr Ala Arg Gly Ala Gly Val His 
            20                  


<210>  16
<211>  19
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Description of Artificial Sequence: Synthetic peptide

<400>  16

Thr Ala Gly Ala Ala Gly Ala Tyr Gln Ala Tyr Pro Gly Thr Ala Arg 
1               5                   10                  15      


Gly Ala Gly 
            


<210>  17
<211>  9
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Description of Artificial Sequence: Synthetic peptide

<400>  17

Asp Thr Ser Gln Asp Gly Gly His Thr 
1               5                   


<210>  18
<211>  9
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Description of Artificial Sequence: Synthetic peptide

<400>  18

Gly Asn His His Ala Asp His Gly Arg 
1               5                   


<210>  19
<211>  9
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Description of Artificial Sequence: Synthetic peptide

<400>  19

Arg His Glu Asp Ala Arg Leu Ser Asp 
1               5                   


<210>  20
<211>  9
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Description of Artificial Sequence: Synthetic peptide

<400>  20

Thr Asp Asn Asp Ala Gly Asn His Asp 
1               5                   


<210>  21
<211>  21
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Description of Artificial Sequence: Synthetic peptide

<400>  21

Thr Ala Gly Lys Asp Asp Val Thr Gly Asp Lys Lys Lys Lys Asn Pro 
1               5                   10                  15      


Glu Ser Gly Ala Gly 
            20      


<210>  22
<211>  21
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Description of Artificial Sequence: Synthetic peptide

<400>  22

Thr Ala Gly Ser Arg Leu Ala Leu Ser Gln Trp Ser Gln Trp Gln Asp 
1               5                   10                  15      


Asp Trp Gly Ala Gly 
            20      


<210>  23
<211>  21
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Description of Artificial Sequence: Synthetic peptide

<400>  23

Thr Ala Gly Tyr Lys Ala Trp Arg Ala Thr Arg Gln Glu Lys Thr Ala 
1               5                   10                  15      


Trp Tyr Gly Ala Gly 
            20      


<210>  24
<211>  21
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Description of Artificial Sequence: Synthetic peptide

<400>  24

Thr Ala Gly Ser Arg Ala Tyr Pro Asp Ser Tyr Ser His Val Lys Arg 
1               5                   10                  15      


Val Ala Gly Ala Gly 
            20      


<210>  25
<211>  27
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Description of Artificial Sequence: Synthetic peptide

<400>  25

Glu Gln Asp Ser Ala Gly Ala Ser Trp Trp Trp Ser Glu Ala His Leu 
1               5                   10                  15      


Trp Gly Leu Thr Ser Gly Ala Asp Ser Thr Tyr 
            20                  25          


<210>  26
<211>  27
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Description of Artificial Sequence: Synthetic peptide

<400>  26

Glu Gln Asp Ser Ala Gly Arg Arg Arg Gly His Lys His Arg Lys Arg 
1               5                   10                  15      


Trp Arg Ser Arg Arg Gly Ala Asp Ser Thr Tyr 
            20                  25          


<210>  27
<211>  13
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Description of Artificial Sequence: Synthetic peptide

<400>  27

Glu Gln Asp Asp Gly Gly His Gln Tyr Ser Ser Thr Tyr 
1               5                   10              


<210>  28
<211>  15
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Description of Artificial Sequence: Synthetic peptide

<400>  28

Glu Gln Asp Ser Gly Gly His Asp Tyr Arg Asp Ser Ser Thr Tyr 
1               5                   10                  15  


<210>  29
<211>  27
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Description of Artificial Sequence: Synthetic peptide

<400>  29

Glu Gln Asp Ser Ala Gly Ala Trp Leu His His Gly Asp Tyr Trp Gly 
1               5                   10                  15      


Gln Glu Asn Pro Ala Gly Ala Asp Ser Thr Tyr 
            20                  25          


<210>  30
<211>  15
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Description of Artificial Sequence: Synthetic peptide

<400>  30

Glu Gln Asp Asn Arg Leu Gln Thr Ser Asn Asp Ala Ser Thr Tyr 
1               5                   10                  15  


<210>  31
<211>  27
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Description of Artificial Sequence: Synthetic peptide

<400>  31

Glu Gln Asp Ser Ala Gly Arg Ser Gln Ala Gln Asn Asn Trp Asp Thr 
1               5                   10                  15      


Tyr Gly Pro Leu Ser Gly Ala Asp Ser Thr Tyr 
            20                  25          


<210>  32
<211>  15
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Description of Artificial Sequence: Synthetic peptide

<400>  32

Glu Gln Asp Gly Thr Ser Gly Arg Tyr Glu Gln Ala Ser Thr Tyr 
1               5                   10                  15  


<210>  33
<211>  27
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Description of Artificial Sequence: Synthetic peptide

<400>  33

Glu Gln Asp Ser Ala Gly Trp Val Val Ser Thr Asp Tyr Ser Pro Gln 
1               5                   10                  15      


Thr Trp Ser Tyr Ala Gly Ala Asp Ser Thr Tyr 
            20                  25          


<210>  34
<211>  15
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Description of Artificial Sequence: Synthetic peptide

<400>  34

Glu Gln Asp Asp Thr Tyr Tyr Leu Ala Val His Gly Ser Thr Tyr 
1               5                   10                  15  


<210>  35
<211>  27
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Description of Artificial Sequence: Synthetic peptide

<400>  35

Glu Gln Asp Ser Ala Gly Lys Asn Ala Val Arg Glu Asn Ala Glu Tyr 
1               5                   10                  15      


Leu Leu Ala Thr Ser Gly Ala Asp Ser Thr Tyr 
            20                  25          


<210>  36
<211>  27
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Description of Artificial Sequence: Synthetic peptide

<400>  36

Glu Gln Asp Ser Ala Gly Ser Gln Ser Ser Asp Pro Gly Ser Asn Gln 
1               5                   10                  15      


Glu Ser His Gln Ser Gly Ala Asp Ser Thr Tyr 
            20                  25          


<210>  37
<211>  27
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Description of Artificial Sequence: Synthetic peptide

<400>  37

Glu Gln Asp Ser Ala Gly Trp Ala Ser Pro Arg Leu Ala Tyr Pro Asp 
1               5                   10                  15      


Thr Val Pro Val Ala Gly Ala Asp Ser Thr Tyr 
            20                  25          


<210>  38
<211>  27
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Description of Artificial Sequence: Synthetic peptide

<400>  38

Glu Gln Asp Ser Ala Gly Ala Asn Arg Leu Lys Gly Gln Lys Gln Pro 
1               5                   10                  15      


Asn Asp Lys Gln Ser Gly Ala Asp Ser Thr Tyr 
            20                  25          


<210>  39
<211>  27
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Description of Artificial Sequence: Synthetic peptide

<400>  39

Glu Gln Asp Ser Ala Gly Ala Asn Ser Pro Leu Gln Asn Arg Arg Glu 
1               5                   10                  15      


Gln Trp Gly Arg Lys Gly Ala Asp Ser Thr Tyr 
            20                  25          


<210>  40
<211>  27
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Description of Artificial Sequence: Synthetic peptide

<400>  40

Glu Gln Asp Ser Ala Gly Ala Pro Trp Tyr Val His Asn Tyr Thr Arg 
1               5                   10                  15      


Trp Arg Lys Asn Trp Gly Ala Asp Ser Thr Tyr 
            20                  25          


<210>  41
<211>  27
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Description of Artificial Sequence: Synthetic peptide

<400>  41

Glu Gln Asp Ser Ala Gly Trp Lys Gln Trp Trp Gly Leu Trp Trp His 
1               5                   10                  15      


Pro Val Gln Thr Ser Gly Ala Asp Ser Thr Tyr 
            20                  25          


<210>  42
<211>  15
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Description of Artificial Sequence: Synthetic peptide

<400>  42

Glu Gln Asp Ser Gly Asp Thr Asn Asn Tyr Thr Arg Ser Thr Tyr 
1               5                   10                  15  


<210>  43
<211>  17
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Description of Artificial Sequence: Synthetic peptide

<400>  43

Ala Gly Ala Ala Gly Ala Tyr Gln Ala Tyr Pro Gly Thr Ala Arg Gly 
1               5                   10                  15      


Ala 
    


<210>  44
<211>  19
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Description of Artificial Sequence: Synthetic peptide

<400>  44

Ala Gly Ser Arg Ala Tyr Pro Asp Ser Tyr Ser His Val Lys Arg Val 
1               5                   10                  15      


Ala Gly Ala 
            


<210>  45
<211>  19
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Description of Artificial Sequence: Synthetic peptide

<400>  45

Ala Gly Ala Ser Trp Trp Trp Ser Glu Ala His Leu Trp Gly Leu Thr 
1               5                   10                  15      


Ser Gly Ala 
            


<210>  46
<211>  19
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Description of Artificial Sequence: Synthetic peptide

<400>  46

Ala Gly Trp Ala Ser Pro Arg Leu Ala Tyr Pro Asp Thr Val Pro Val 
1               5                   10                  15      


Ala Gly Ala 
            


<210>  47
<211>  4
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Description of Artificial Sequence: Synthetic peptide

<400>  47

Gly Ala Leu Thr 
1               


<210>  48
<211>  4
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Description of Artificial Sequence: Synthetic peptide

<400>  48

Ser Gly Val His 
1               


