                         SEQUENCE LISTING

<110>  Merck Sharp & Dohme Corp.
       Axnanda, Stephanus
       Brunskill, Andrew
       Guidry, Erin N.
       Kemp, Eric A.
       Maguire, Courtney K.
       Reibarkh, Mikhail
       Winston, Matthew S.
 
<120>  NOVEL FORMS OF CYCLIC DINUCLEOTIDE COMPOUNDS

<130>  25221-WO-PCT

<150>  63/177,503

<151>  2021-04-21

<160>  7     

<170>  PatentIn version 3.5

<210>  1
<211>  229
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificial ketoreductase

<400>  1

Met His His His His His Pro Ala Thr Ile Val Val Thr Gly Gly Thr 
1               5                   10                  15      


Lys Gly Ile Gly Arg Ala Ile Val Glu Lys Phe Ala Lys Glu Gly Phe 
            20                  25                  30          


Thr Val Leu Thr Cys Ala Arg Thr Lys Gly Asp Asn Phe Pro Glu Asn 
        35                  40                  45              


Val His Phe Phe Lys Ala Asp Leu Ser Lys Lys Val Glu Val Leu Ala 
    50                  55                  60                  


Phe Ala Asp Phe Ile Lys Gln Thr Val Asn Gln Val Asp Ile Leu Val 
65                  70                  75                  80  


Asn Asn Thr Gly Trp Phe Leu Pro Gly Glu Ile Asn Asn Glu Ala Glu 
                85                  90                  95      


Gly Thr Leu Glu Ala Met Ile Glu Thr Asn Leu Tyr Ser Ala Tyr Tyr 
            100                 105                 110         


Leu Thr Arg Ala Leu Val Gly Asp Met Ile Thr Lys Lys Glu Gly His 
        115                 120                 125             


Ile Phe Asn Ile Cys Ser Tyr Ala Ser Ile Val Pro Tyr Thr Ser Gly 
    130                 135                 140                 


Gly Ser Tyr Cys Ile Ser Lys Thr Ala Gln Leu Gly Met Ser Lys Val 
145                 150                 155                 160 


Leu Arg Glu Glu Leu Lys Pro His His Val Arg Val Thr Ser Ile Leu 
                165                 170                 175     


Pro Gly Ala Val Leu Asn Asp Ser Trp Ala Lys Val Glu Leu Pro Ala 
            180                 185                 190         


Glu Leu Phe Ile Ala Pro Glu Asp Ile Ala Gln Ile Val Trp Thr Ala 
        195                 200                 205             


His Cys Leu Pro Ser Thr Thr Val Leu Glu Glu Ile Leu Ile Arg Pro 
    210                 215                 220                 


Gln Thr Gly Asp Leu 
225                 


<210>  2
<211>  223
<212>  PRT
<213>  Branchistoma floridae

<400>  2

Met Ala Leu Pro Arg Pro Val Val Ile Cys Gly Pro Ser Gly Ser Gly 
1               5                   10                  15      


Lys Ser Thr Leu Tyr Asn Lys Leu Leu Lys Glu Phe Pro Gly Val Phe 
            20                  25                  30          


Gln Leu Ser Val Ser His Thr Thr Arg Gln Pro Arg Pro Gly Glu Leu 
        35                  40                  45              


Asn Gly Arg Glu Tyr His Phe Ile Asn Arg Asp Gln Phe Gln Glu Asn 
    50                  55                  60                  


Ile Lys Gln Gly Asp Phe Leu Glu Trp Ala Glu Phe Ser Gly Asn Ile 
65                  70                  75                  80  


Tyr Gly Thr Ser Lys Lys Ala Leu Glu Glu Val Gln Ser Asn Asn Val 
                85                  90                  95      


Ile Pro Ile Leu Asp Ile Asp Thr Gln Gly Val Arg Asn Val Lys Lys 
            100                 105                 110         


Ala Ser Leu Glu Ala Val Tyr Ile Phe Ile Lys Pro Pro Ser Ile Asp 
        115                 120                 125             


Val Leu Glu Lys Arg Leu Arg Ser Arg Lys Thr Glu Thr Glu Glu Ala 
    130                 135                 140                 


Leu Gln Lys Arg Leu Ser Ala Ala Arg Asn Glu Leu Glu Tyr Gly Leu 
145                 150                 155                 160 


Lys Pro Gly Asn Phe Gln His Ile Ile Thr Asn Asp Asp Leu Asp Val 
                165                 170                 175     


Ala Tyr Glu Lys Leu Lys Gly Ile Leu Ile Lys Ser Gln Met Pro Leu 
            180                 185                 190         


Ala Met Ala Thr Gly Ser Ser Ser Ser Val Val Asn Ser Phe Leu Asp 
        195                 200                 205             


Lys Pro Ala Ala Ser Ala Thr Thr Val Asn Ser Ser Ser Gln Asp 
    210                 215                 220             


<210>  3
<211>  228
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  adenylate kinase

<400>  3

Met His His His His His His Ser Ser Ser Glu Ser Ile Arg Met Val 
1               5                   10                  15      


Leu Ile Gly Pro Pro Gly Ala Gly Lys Gly Thr Gln Ala Pro Asn Leu 
            20                  25                  30          


Gln Glu Arg Phe His Ala Cys His Leu Ala Thr Gly Asp Met Leu Arg 
        35                  40                  45              


Ser Gln Ile Ala Lys Gly Thr Gln Leu Gly Leu Glu Ala Lys Lys Ile 
    50                  55                  60                  


Met Asp Gln Gly Gly Leu Val Ser Asp Asp Ile Met Val Asn Met Ile 
65                  70                  75                  80  


Lys Asp Glu Leu Thr Asn Asn Pro Ala Cys Lys Asn Gly Phe Ile Leu 
                85                  90                  95      


Asp Gly Phe Pro Arg Thr Ile Pro Gln Ala Glu Lys Leu Asp Gln Met 
            100                 105                 110         


Leu Lys Glu Gln Gly Thr Pro Leu Glu Lys Ala Val Glu Leu Lys Ile 
        115                 120                 125             


Asp Asp Glu Leu Leu Pro Ala Arg Ile Thr Gly Arg Leu Ile His Pro 
    130                 135                 140                 


Ala Ser Gly Arg Ser Tyr His Lys Ile Phe Asn Pro Pro Lys Glu Asp 
145                 150                 155                 160 


Met Lys Asp Asp Val Thr Gly Glu Ala Leu Val Gln Arg Ser Asp Asp 
                165                 170                 175     


Asn Ala Asp Ala Leu Lys Lys Arg Leu Ala Ala Tyr His Lys Gln Thr 
            180                 185                 190         


Glu Pro Val Val Asp Phe Tyr Lys Lys Thr Gly Ile Trp Ala Gly Val 
        195                 200                 205             


Asp Ala Ser Gln Pro Pro Ala Thr Val Trp Ala Asp Ile Leu Asn Lys 
    210                 215                 220                 


Leu Gly Lys Asp 
225             


<210>  4
<211>  228
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  adenylate kinase

<400>  4

Met His His His His His His Ser Ser Ser Glu Ser Ile Arg Met Val 
1               5                   10                  15      


Leu Ile Gly Pro Pro Gly Ala Gly Lys Gly Thr Gln Ser Pro Asn Leu 
            20                  25                  30          


Gln Glu Arg Phe His Ala Cys His Leu Gly Thr Gly Asp Met Leu Arg 
        35                  40                  45              


Ser Gln His Ala Lys Gly Thr Gln Leu Gly Leu Glu Ala Lys Lys Ile 
    50                  55                  60                  


Met Asp Gln Gly Gly Leu Val Ser Asp Asp Ile Met Val Asn Met Ile 
65                  70                  75                  80  


Lys Asp Glu Leu Thr Asn Asn Pro Ala Cys Lys Asn Gly Phe Ile Leu 
                85                  90                  95      


Asp Gly Phe Pro Arg Thr Ile Pro Gln Ala Met Lys Leu Glu Gln Met 
            100                 105                 110         


Leu Lys Glu Gln Gly Thr Pro Leu Glu Lys Ala Val Glu Leu Lys Ile 
        115                 120                 125             


Asp Asp Glu Leu Leu Pro Ala Arg Ile Thr Gly Arg Leu Ile His Pro 
    130                 135                 140                 


Ala Ser Gly Arg Ser Tyr His Lys Ile Phe Asn Pro Pro Lys Glu Asp 
145                 150                 155                 160 


Met Lys Asp Asp Val Thr Gly Glu Ala Leu Val Gln Arg Ser Asp Asp 
                165                 170                 175     


Asn Ala Asp Ala Leu Lys Lys Arg Leu Ala Ala Tyr His Lys Gln Thr 
            180                 185                 190         


Glu Pro Val Val Asp Phe Tyr Lys Lys Ala Gly Ile Trp Ala Gly Val 
        195                 200                 205             


Asp Ala Ser Gln Pro Val Ala Thr Val Trp Ala Asp Ile Leu Asn Lys 
    210                 215                 220                 


Leu Gly Lys Asp 
225             


<210>  5
<211>  412
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  acetate kinase

<400>  5

Met Gly Ser His His His His His Gly Ser Arg Val Leu Val Ile Asn 
1               5                   10                  15      


Ser Gly Ser Ser Ser Ile Lys Tyr Gln Leu Ile Glu Met Glu Gly Glu 
            20                  25                  30          


Lys Val Leu Cys Lys Gly Ile Ala Glu Arg Ile Gly Ile Glu Gly Ser 
        35                  40                  45              


Arg Leu Val His Arg Val Gly Asp Glu Lys His Val Ile Glu Arg Glu 
    50                  55                  60                  


Leu Pro Asp His Glu Glu Ala Leu Lys Leu Ile Leu Asn Thr Leu Val 
65                  70                  75                  80  


Asp Glu Lys Leu Gly Val Ile Lys Asp Leu Lys Glu Ile Asp Ala Val 
                85                  90                  95      


Gly His Arg Val Val His Gly Gly Glu Arg Phe Lys Glu Ser Val Leu 
            100                 105                 110         


Val Asp Glu Glu Val Leu Lys Ala Ile Glu Glu Val Ser Pro Leu Ala 
        115                 120                 125             


Pro Leu His Asn Pro Ala Asn Leu Met Gly Ile Lys Val Ala Met Lys 
    130                 135                 140                 


Leu Leu Pro Gly Val Pro Asn Val Ala Val Phe Asp Thr Ala Phe His 
145                 150                 155                 160 


Gln Thr Ile Pro Gln Lys Ala Tyr Leu Tyr Ala Ile Pro Tyr Glu Tyr 
                165                 170                 175     


Tyr Glu Lys Tyr Lys Ile Arg Arg Tyr Gly Phe His Gly Thr Ser His 
            180                 185                 190         


Arg Tyr Val Ser Lys Arg Ala Ala Glu Ile Leu Gly Lys Lys Leu Glu 
        195                 200                 205             


Glu Leu Lys Ile Ile Thr Cys His Ile Gly Asn Gly Ala Ser Val Ala 
    210                 215                 220                 


Ala Val Lys Tyr Gly Lys Cys Val Asp Thr Ser Met Gly Phe Thr Pro 
225                 230                 235                 240 


Thr Glu Gly Leu Val Met Gly Thr Arg Ser Gly Asp Leu Asp Pro Ala 
                245                 250                 255     


Ile Pro Phe Phe Ile Met Glu Lys Glu Gly Ile Ser Pro Gln Glu Met 
            260                 265                 270         


Tyr Asp Ile Leu Asn Lys Lys Ser Gly Val Tyr Gly Leu Ser Lys Gly 
        275                 280                 285             


Phe Ser Ser Asp Leu Arg Asp Ile Glu Glu Ala Ala Leu Lys Gly Asp 
    290                 295                 300                 


Glu Trp Cys Lys Leu Val Leu Glu Ile Tyr Asp Tyr Arg Ile Ala Lys 
305                 310                 315                 320 


Tyr Ile Gly Ala Tyr Ala Ala Ala Met Asn Gly Val Asp Ala Ile Val 
                325                 330                 335     


Phe Thr Ala Gly Val Cys Glu Asn Ser Pro Ile Thr Arg Glu Asp Val 
            340                 345                 350         


Cys Ser Tyr Leu Glu Phe Leu Gly Val Lys Leu Asp Lys Gln Lys Asn 
        355                 360                 365             


Glu Glu Thr Ile Asp Gly Lys Glu Gly Ile Ile Ser Thr Pro Asp Ser 
    370                 375                 380                 


Arg Val Lys Val Leu Val Val Pro Thr Asn Glu Glu Leu Met Ile Ala 
385                 390                 395                 400 


Arg Asp Thr Lys Glu Ile Val Glu Lys Ile Gly Arg 
                405                 410         


<210>  6
<211>  229
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  guanylate kinase

<400>  6

Met His His His His His His Ala Leu Pro Thr Pro Val Val Ile Cys 
1               5                   10                  15      


Gly Pro Ser Gly Ser Gly Lys Thr Thr Leu Tyr Asn Lys Leu Leu Lys 
            20                  25                  30          


Glu Phe Pro Gly Val Phe Gln Leu Thr Ala Ser His Thr Thr Arg Gln 
        35                  40                  45              


Pro Arg Pro Gly Glu Glu Asn Gly Arg Glu Phe His Phe Ile Asn Arg 
    50                  55                  60                  


Asp Gln Phe Gln Glu Asn Ile Lys Gln Gly Asp Phe Leu Glu Trp Ala 
65                  70                  75                  80  


Glu His Ser Gly Asn Leu Tyr Gly Thr Ser Lys Lys Ala Leu Glu Glu 
                85                  90                  95      


Val Gln Ala Asn Asn Val Ile Pro Ile Leu Asp Ile Asp Thr Gln Gly 
            100                 105                 110         


Val Arg Thr Val Lys Lys Ala Ser Leu Glu Ala Val Tyr Ile Phe Ile 
        115                 120                 125             


Lys Pro Pro Ser Ile Glu Val Leu Glu Glu Arg Leu Arg Ser Arg Gly 
    130                 135                 140                 


Thr Glu Thr Glu Glu Ala Leu Gln Lys Arg Leu Ser Ala Ala Pro Asn 
145                 150                 155                 160 


Glu Leu Glu Tyr Gly Leu Lys Pro Gly Asn Phe Gln His Ile Ile Thr 
                165                 170                 175     


Asn Asp Asp Leu Asp Val Ala Tyr Glu Lys Leu Lys Gly Ile Leu Ile 
            180                 185                 190         


Asp Ser Gln Met Pro Leu Ala Gly Ala Thr Gly Ser Ser Ser Ser Val 
        195                 200                 205             


Val Asn Ser Phe Leu Asp Lys Pro Ala Ala Ser Ala Thr Thr Val Asn 
    210                 215                 220                 


Ser Ser Ser Gln Asp 
225                 


<210>  7
<211>  476
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  cGAS

<400>  7

Met His His His His His His Gly Ser Asp Ser Glu Val Asn Gln Glu 
1               5                   10                  15      


Ala Lys Pro Glu Val Lys Pro Glu Val Lys Pro Glu Thr His Ile Asn 
            20                  25                  30          


Leu Lys Val Ser Asp Gly Ser Ser Glu Ile Phe Phe Lys Ile Lys Lys 
        35                  40                  45              


Thr Thr Pro Leu Arg Arg Leu Met Glu Ala Phe Ala Lys Arg Gln Gly 
    50                  55                  60                  


Lys Glu Met Asp Ser Leu Thr Phe Leu Tyr Asp Gly Ile Glu Ile Gln 
65                  70                  75                  80  


Ala Asp Gln Thr Pro Glu Asp Leu Asp Met Glu Asp Asn Asp Ile Ile 
                85                  90                  95      


Glu Ala His Arg Glu Gln Ile Gly Gly Glu Asn Leu Tyr Phe Gln Gly 
            100                 105                 110         


Gly Gly Pro Arg Leu Arg Glu Val Leu Ser Arg Leu Ser Leu Gly Arg 
        115                 120                 125             


Gln Asp Val Ser Glu Ala Ser Gly Leu Val Asn Gln Val Val Ser Gln 
    130                 135                 140                 


Leu Ile Gln Ala Ile Arg Ser Gln Glu Gly Ser Phe Gly Ser Ile Glu 
145                 150                 155                 160 


Arg Leu Asn Thr Gly Ser Tyr Tyr Glu His Val Lys Ile Ser Glu Pro 
                165                 170                 175     


Asn Glu Phe Asp Ile Met Leu Val Met Pro Val Ser Arg Leu Gln Leu 
            180                 185                 190         


Asp Glu Cys Asp Asp Thr Gly Ala Phe Tyr Tyr Leu Thr Phe Lys Arg 
        195                 200                 205             


Asn Ser Lys Asp Lys His Leu Phe Lys Phe Leu Asp Glu Asp Gly Lys 
    210                 215                 220                 


Leu Ser Ala Phe Lys Met Leu Gln Ala Leu Arg Asp Ile Ile Lys Arg 
225                 230                 235                 240 


Glu Val Lys Asn Ile Lys Asn Ala Glu Val Thr Val Lys Arg Lys Lys 
                245                 250                 255     


Ala Gly Ser Pro Ala Ile Thr Leu Gln Ile Lys Asn Pro Pro Ala Val 
            260                 265                 270         


Ile Ser Val Asp Ile Ile Leu Thr Leu Glu Pro Gln Gln Ser Trp Pro 
        275                 280                 285             


Pro Ser Thr Gln Asp Gly Leu Lys Ile Glu Lys Trp Leu Gly Arg Lys 
    290                 295                 300                 


Val Arg Gly Gln Phe Arg Asn Lys Ser Leu Tyr Leu Val Ala Lys Gln 
305                 310                 315                 320 


Asn Pro Arg Glu Lys Val Leu Arg Gly Asn Thr Trp Arg Leu Ser Phe 
                325                 330                 335     


Ser His Ile Glu Lys Asp Met Leu Asn Asn His Gly Ser Ser Lys Thr 
            340                 345                 350         


Cys Cys Glu Ser Asp Gly Leu Lys Cys Cys Arg Lys Gly Cys Tyr Lys 
        355                 360                 365             


Leu Leu Lys Tyr Leu Leu Glu Arg Leu Lys Met Lys Tyr Pro His Gln 
    370                 375                 380                 


Leu Glu Lys Arg Ser Ser Tyr Glu Val Lys Thr Ala Phe Phe His Ser 
385                 390                 395                 400 


Cys Val Met Trp Pro Asn Asp Leu Asp Trp His Leu Ser Asp Leu Asp 
                405                 410                 415     


Tyr Cys Phe Gln Lys Tyr Leu Gly Tyr Phe Leu Asp Cys Leu Gln Lys 
            420                 425                 430         


Ser Glu Leu Pro His Phe Phe Ile Pro Gln Tyr Asn Leu Leu Ser Leu 
        435                 440                 445             


Glu Asp Lys Ala Ser Asn Asp Phe Leu Ser Arg Gln Ile Asn Tyr Glu 
    450                 455                 460                 


Leu Asn Asn Arg Phe Pro Ile Phe Gln Glu Arg Tyr 
465                 470                 475     


