                         SEQUENCE LISTING

<110>  RAMOT AT TEL-AVIV UNIVERSITY LTD.
 
<120>  HUMANIZED ANTI-SIALYL-TN GLYCAN ANTIBODIES AND USES THEREOF

<130>  RAMOT/0106 PCT

<150>  63176895
<151>  2021-04-20

<160>  51    

<170>  PatentIn version 3.5

<210>  1
<211>  113
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthesized sequence

<400>  1

Gln Val Gln Leu Gln Glu Ser Gly Pro Gly Leu Val Ala Pro Ser Gln 
1               5                   10                  15      


Ser Leu Ser Ile Thr Cys Thr Val Ser Gly Phe Ser Leu Ile Ser Tyr 
            20                  25                  30          


Gly Val Ser Trp Val Arg Gln Pro Pro Gly Lys Gly Leu Glu Trp Leu 
        35                  40                  45              


Gly Val Ile Trp Gly Asp Gly Ser Thr Asn Tyr His Ser Thr Leu Ile 
    50                  55                  60                  


Ser Arg Leu Ser Ile Asn Lys Asp Asn Ser Lys Ser Gln Val Phe Leu 
65                  70                  75                  80  


Lys Leu Asn Ser Leu Gln Thr Asp Asp Thr Ala Thr Tyr Tyr Cys Val 
                85                  90                  95      


Gly Pro Arg Phe Ala Tyr Trp Gly Gln Gly Thr Leu Val Thr Val Ser 
            100                 105                 110         


Ala 
    


<210>  2
<211>  106
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthesized sequence

<400>  2

Gln Ile Val Leu Thr Gln Ser Pro Ala Ile Met Ser Ala Ser Pro Gly 
1               5                   10                  15      


Glu Lys Val Thr Met Thr Cys Ser Ala Ser Ser Ser Val Ser Tyr Met 
            20                  25                  30          


His Trp Tyr Gln Gln Lys Ser Gly Thr Ser Pro Lys Arg Trp Ile Tyr 
        35                  40                  45              


Asp Thr Ser Lys Leu Thr Ser Gly Val Pro Ala Arg Phe Ser Gly Ser 
    50                  55                  60                  


Gly Ser Gly Thr Ser Tyr Ser Leu Thr Ile Ser Ser Met Glu Ala Glu 
65                  70                  75                  80  


Asp Ala Ala Thr Tyr Tyr Cys Gln Gln Trp Ser Ser Asn Thr Leu Thr 
                85                  90                  95      


Phe Gly Ala Gly Thr Lys Leu Glu Leu Lys 
            100                 105     


<210>  3
<211>  5
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthesized sequence

<400>  3

Ser Tyr Gly Val Ser 
1               5   


<210>  4
<211>  16
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthesized sequence

<400>  4

Val Ile Trp Gly Asp Gly Ser Thr Asn Tyr His Ser Thr Leu Ile Ser 
1               5                   10                  15      


<210>  5
<211>  5
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthesized sequence

<400>  5

Pro Arg Phe Ala Tyr 
1               5   


<210>  6
<211>  10
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthesized sequence

<400>  6

Ser Ala Ser Ser Ser Val Ser Tyr Met His 
1               5                   10  


<210>  7
<211>  7
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthesized sequence

<400>  7

Asp Thr Ser Lys Leu Thr Ser 
1               5           


<210>  8
<211>  9
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthesized sequence

<400>  8

Gln Gln Trp Ser Ser Asn Thr Leu Thr 
1               5                   


<210>  9
<211>  5
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthesized sequence

<400>  9

Gly Gly Gly Gly Ser 
1               5   


<210>  10
<211>  15
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthesized sequence

<400>  10

Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser 
1               5                   10                  15  


<210>  11
<211>  10
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthesized sequence

<400>  11

Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser 
1               5                   10  


<210>  12
<211>  40
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthesized sequence

<400>  12

Ser Lys Arg Ser Arg Leu Leu His Ser Asp Tyr Met Asn Met Thr Pro 
1               5                   10                  15      


Arg Arg Pro Gly Pro Thr Arg Lys His Tyr Gln Pro Tyr Ala Pro Pro 
            20                  25                  30          


Arg Asp Phe Ala Ala Tyr Arg Ser 
        35                  40  


<210>  13
<211>  110
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthesized sequence

<400>  13

Ala Ala Ala Ile Glu Val Met Tyr Pro Pro Pro Tyr Leu Asp Asn Glu 
1               5                   10                  15      


Lys Ser Asn Gly Thr Ile Ile His Val Lys Gly Lys His Leu Cys Pro 
            20                  25                  30          


Ser Pro Leu Phe Pro Gly Pro Ser Lys Pro Phe Trp Val Leu Val Val 
        35                  40                  45              


Val Gly Gly Val Leu Ala Cys Tyr Ser Leu Leu Val Thr Val Ala Phe 
    50                  55                  60                  


Ile Ile Phe Trp Val Arg Ser Lys Arg Ser Arg Leu Leu His Ser Asp 
65                  70                  75                  80  


Tyr Met Asn Met Thr Pro Arg Arg Pro Gly Pro Thr Arg Lys His Tyr 
                85                  90                  95      


Gln Pro Tyr Ala Pro Pro Arg Asp Phe Ala Ala Tyr Arg Ser 
            100                 105                 110 


<210>  14
<211>  38
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthesized sequence

<400>  14

Gln Val Arg Lys Ala Ala Ile Thr Ser Tyr Glu Lys Ser Asp Gly Val 
1               5                   10                  15      


Tyr Thr Gly Leu Ser Thr Arg Asn Gln Glu Thr Tyr Glu Thr Leu Lys 
            20                  25                  30          


His Glu Lys Pro Pro Gln 
        35              


<210>  15
<211>  22
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthesized sequence

<400>  15

Met Asp Phe Gln Val Gln Ile Phe Ser Phe Leu Leu Ile Ser Ala Ser 
1               5                   10                  15      


Val Ile Met Ser Arg Gly 
            20          


<210>  16
<211>  339
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Synthesized sequence

<400>  16
caggtgcagc tgcaggagtc tggacctggc ctggtggcgc cctcacagag cctgtccatc       60

acatgcactg tctcagggtt ctcattaatc agctatggtg taagctgggt tcgccagcct      120

ccaggaaagg gtctggagtg gctgggagta atatggggtg acgggagcac aaattatcat      180

tcaactctca tatccagact gagcatcaac aaggataact ccaagagcca agttttctta      240

aaactgaaca gtctgcaaac tgatgacaca gccacgtact actgtgtcgg accccggttt      300

gcttactggg gccaagggac tctggtcact gtctctgca                             339


<210>  17
<211>  318
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Synthesized sequence

<400>  17
caaattgttc tcacccagtc tccagcaatc atgtctgcat ctccagggga gaaggtcacc       60

atgacctgca gtgccagctc aagtgtaagt tacatgcact ggtaccagca gaagtcaggc      120

acctccccca aaagatggat ttatgacaca tccaaactga cttctggagt ccctgctcgc      180

ttcagtggca gtgggtctgg gacctcttac tctctcacaa tcagcagcat ggaggctgaa      240

gatgctgcca cttattactg ccagcagtgg agtagtaata cgctcacgtt cggtgctggg      300

accaagctgg agctgaaa                                                    318


<210>  18
<211>  45
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Synthesized sequence

<400>  18
ggaggtggcg gtagcggagg cggcggttct ggaggtggcg ggagc                       45


<210>  19
<211>  15
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Synthesized sequence

<400>  19
ggaggtggcg gtagc                                                        15


<210>  20
<211>  30
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Synthesized sequence

<400>  20
ggaggtggcg gtagcggagg cggcggttct                                        30


<210>  21
<211>  60
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Synthesized sequence

<400>  21
ggaggtggcg gtagcggagg cggcggttct ggaggtggcg ggagcggagg cggcggttct       60


<210>  22
<211>  330
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Synthesized sequence

<400>  22
gcggccgcaa ttgaagttat gtatcctcct ccttacctag acaatgagaa gagcaatgga       60

accattatcc atgtgaaagg gaaacacctt tgtccaagtc ccctatttcc cggaccttct      120

aagccctttt gggtgctggt ggtggttggt ggagtcctgg cttgctatag cttgctagta      180

acagtggcct ttattatttt ctgggtgagg agtaagagga gcaggctcct gcacagtgac      240

tacatgaaca tgactccccg ccgccccggg cccacccgca agcattacca gccctatgcc      300

ccaccacgcg acttcgcagc ctatagatct                                       330


<210>  23
<211>  117
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Synthesized sequence

<400>  23
caagtgcgaa aggcagctat aaccagctat gagaaatcag atggtgttta cacgggcctg       60

agcaccagga accaggagac ttacgagact ctgaagcatg agaaaccacc acagtag         117


<210>  24
<211>  66
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Synthesized sequence

<400>  24
atggattttc aggtgcagat tttcagcttc ctgctaatca gtgcctcagt cataatgtcc       60

agagga                                                                  66


<210>  25
<211>  113
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthesized sequence

<400>  25

Gln Val Thr Leu Arg Glu Ser Gly Pro Ala Leu Val Lys Pro Thr Gln 
1               5                   10                  15      


Thr Leu Thr Leu Thr Cys Thr Phe Ser Gly Phe Ser Leu Ile Ser Tyr 
            20                  25                  30          


Gly Val Ser Trp Val Arg Gln Pro Pro Gly Lys Ala Leu Glu Trp Leu 
        35                  40                  45              


Gly Val Ile Trp Gly Asp Gly Ser Thr Asn Tyr His Ser Thr Leu Ile 
    50                  55                  60                  


Ser Arg Leu Thr Ile Ser Lys Asp Thr Ser Lys Asn Gln Val Val Leu 
65                  70                  75                  80  


Thr Met Thr Asn Met Asp Pro Val Asp Thr Ala Thr Tyr Tyr Cys Val 
                85                  90                  95      


Gly Pro Arg Phe Ala Tyr Trp Gly Gln Gly Thr Leu Val Thr Val Ser 
            100                 105                 110         


Ser 
    


<210>  26
<211>  106
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthesized sequence

<400>  26

Glu Ile Val Leu Thr Gln Ser Pro Ala Thr Leu Ser Leu Ser Pro Gly 
1               5                   10                  15      


Glu Arg Ala Thr Leu Ser Cys Ser Ala Ser Ser Ser Val Ser Tyr Met 
            20                  25                  30          


His Trp Tyr Gln Gln Lys Pro Gly Gln Ala Pro Arg Leu Leu Ile Tyr 
        35                  40                  45              


Asp Thr Ser Lys Leu Thr Ser Gly Ile Pro Ala Arg Phe Ser Gly Ser 
    50                  55                  60                  


Gly Ser Gly Thr Asp Phe Thr Leu Thr Ile Ser Ser Leu Glu Pro Glu 
65                  70                  75                  80  


Asp Phe Ala Val Tyr Tyr Cys Gln Gln Trp Ser Ser Asn Thr Leu Thr 
                85                  90                  95      


Phe Gly Gln Gly Thr Lys Leu Glu Ile Lys 
            100                 105     


<210>  27
<211>  113
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthesized sequence

<400>  27

Gln Val Gln Leu Gln Glu Ser Gly Pro Gly Leu Val Lys Pro Ser Glu 
1               5                   10                  15      


Thr Leu Ser Leu Thr Cys Thr Val Ser Gly Gly Ser Ile Ser Ser Tyr 
            20                  25                  30          


Gly Val Ser Trp Ile Arg Gln Pro Pro Gly Lys Gly Leu Glu Trp Ile 
        35                  40                  45              


Gly Val Ile Trp Gly Asp Gly Ser Thr Asn Tyr His Ser Thr Leu Ile 
    50                  55                  60                  


Ser Arg Val Thr Ile Ser Val Asp Thr Ser Lys Asn Gln Phe Ser Leu 
65                  70                  75                  80  


Lys Leu Ser Ser Val Thr Ala Ala Asp Thr Ala Val Tyr Tyr Cys Val 
                85                  90                  95      


Gly Pro Arg Phe Ala Tyr Trp Gly Gln Gly Thr Leu Val Thr Val Ser 
            100                 105                 110         


Ser 
    


<210>  28
<211>  113
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthesized sequence

<400>  28

Gln Val Gln Leu Gln Glu Ser Gly Pro Ala Leu Val Lys Pro Thr Gln 
1               5                   10                  15      


Thr Leu Ser Ile Thr Cys Thr Val Ser Gly Phe Ser Leu Ile Ser Tyr 
            20                  25                  30          


Gly Val Ser Trp Val Arg Gln Pro Pro Gly Lys Ala Leu Glu Trp Leu 
        35                  40                  45              


Gly Val Ile Trp Gly Asp Gly Ser Thr Asn Tyr His Ser Thr Leu Ile 
    50                  55                  60                  


Ser Arg Leu Ser Ile Asn Lys Asp Thr Ser Lys Asn Gln Val Phe Leu 
65                  70                  75                  80  


Lys Leu Thr Asn Met Gln Thr Asp Asp Thr Ala Thr Tyr Tyr Cys Val 
                85                  90                  95      


Gly Pro Arg Phe Ala Tyr Trp Gly Gln Gly Thr Leu Val Thr Val Ser 
            100                 105                 110         


Ser 
    


<210>  29
<211>  106
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthesized sequence

<400>  29

Glu Ile Val Leu Thr Gln Ser Pro Ala Thr Leu Ser Leu Ser Pro Gly 
1               5                   10                  15      


Glu Arg Val Thr Met Thr Cys Ser Ala Ser Ser Ser Val Ser Tyr Met 
            20                  25                  30          


His Trp Tyr Gln Gln Lys Pro Gly Gln Ala Pro Lys Arg Trp Ile Tyr 
        35                  40                  45              


Asp Thr Ser Lys Leu Thr Ser Gly Ile Pro Ala Arg Phe Ser Gly Ser 
    50                  55                  60                  


Gly Ser Gly Thr Ser Tyr Ser Leu Thr Ile Ser Ser Leu Glu Ala Glu 
65                  70                  75                  80  


Asp Ala Ala Thr Tyr Tyr Cys Gln Gln Trp Ser Ser Asn Thr Leu Thr 
                85                  90                  95      


Phe Gly Gln Gly Thr Lys Leu Glu Ile Lys 
            100                 105     


<210>  30
<211>  106
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthesized sequence

<400>  30

Glu Ile Val Leu Thr Gln Ser Pro Ala Thr Leu Ser Leu Ser Pro Gly 
1               5                   10                  15      


Glu Arg Ala Thr Leu Ser Cys Ser Ala Ser Ser Ser Val Ser Tyr Met 
            20                  25                  30          


His Trp Tyr Gln Gln Lys Pro Gly Gln Ala Pro Lys Arg Trp Ile Tyr 
        35                  40                  45              


Asp Thr Ser Lys Leu Thr Ser Gly Ile Pro Ala Arg Phe Ser Gly Ser 
    50                  55                  60                  


Gly Ser Gly Thr Asp Phe Thr Leu Thr Ile Ser Ser Leu Glu Ala Glu 
65                  70                  75                  80  


Asp Ala Ala Thr Tyr Tyr Cys Gln Gln Trp Ser Ser Asn Thr Leu Thr 
                85                  90                  95      


Phe Gly Gln Gly Thr Lys Leu Glu Ile Lys 
            100                 105     


<210>  31
<211>  234
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthesized sequence

<400>  31

Gln Val Gln Leu Gln Glu Ser Gly Pro Ala Leu Val Lys Pro Thr Gln 
1               5                   10                  15      


Thr Leu Ser Ile Thr Cys Thr Val Ser Gly Phe Ser Leu Ile Ser Tyr 
            20                  25                  30          


Gly Val Ser Trp Val Arg Gln Pro Pro Gly Lys Ala Leu Glu Trp Leu 
        35                  40                  45              


Gly Val Ile Trp Gly Asp Gly Ser Thr Asn Tyr His Ser Thr Leu Ile 
    50                  55                  60                  


Ser Arg Leu Ser Ile Asn Lys Asp Thr Ser Lys Asn Gln Val Phe Leu 
65                  70                  75                  80  


Lys Leu Thr Asn Met Gln Thr Asp Asp Thr Ala Thr Tyr Tyr Cys Val 
                85                  90                  95      


Gly Pro Arg Phe Ala Tyr Trp Gly Gln Gly Thr Leu Val Thr Val Ser 
            100                 105                 110         


Ser Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser 
        115                 120                 125             


Glu Ile Val Leu Thr Gln Ser Pro Ala Thr Leu Ser Leu Ser Pro Gly 
    130                 135                 140                 


Glu Arg Val Thr Met Thr Cys Ser Ala Ser Ser Ser Val Ser Tyr Met 
145                 150                 155                 160 


His Trp Tyr Gln Gln Lys Pro Gly Gln Ala Pro Lys Arg Trp Ile Tyr 
                165                 170                 175     


Asp Thr Ser Lys Leu Thr Ser Gly Ile Pro Ala Arg Phe Ser Gly Ser 
            180                 185                 190         


Gly Ser Gly Thr Ser Tyr Ser Leu Thr Ile Ser Ser Leu Glu Ala Glu 
        195                 200                 205             


Asp Ala Ala Thr Tyr Tyr Cys Gln Gln Trp Ser Ser Asn Thr Leu Thr 
    210                 215                 220                 


Phe Gly Gln Gly Thr Lys Leu Glu Ile Lys 
225                 230                 


<210>  32
<211>  234
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthesized sequence

<400>  32

Gln Val Gln Leu Gln Glu Ser Gly Pro Ala Leu Val Lys Pro Thr Gln 
1               5                   10                  15      


Thr Leu Ser Ile Thr Cys Thr Val Ser Gly Phe Ser Leu Ile Ser Tyr 
            20                  25                  30          


Gly Val Ser Trp Val Arg Gln Pro Pro Gly Lys Ala Leu Glu Trp Leu 
        35                  40                  45              


Gly Val Ile Trp Gly Asp Gly Ser Thr Asn Tyr His Ser Thr Leu Ile 
    50                  55                  60                  


Ser Arg Leu Ser Ile Asn Lys Asp Thr Ser Lys Asn Gln Val Phe Leu 
65                  70                  75                  80  


Lys Leu Thr Asn Met Gln Thr Asp Asp Thr Ala Thr Tyr Tyr Cys Val 
                85                  90                  95      


Gly Pro Arg Phe Ala Tyr Trp Gly Gln Gly Thr Leu Val Thr Val Ser 
            100                 105                 110         


Ser Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser 
        115                 120                 125             


Glu Ile Val Leu Thr Gln Ser Pro Ala Thr Leu Ser Leu Ser Pro Gly 
    130                 135                 140                 


Glu Arg Ala Thr Leu Ser Cys Ser Ala Ser Ser Ser Val Ser Tyr Met 
145                 150                 155                 160 


His Trp Tyr Gln Gln Lys Pro Gly Gln Ala Pro Lys Arg Trp Ile Tyr 
                165                 170                 175     


Asp Thr Ser Lys Leu Thr Ser Gly Ile Pro Ala Arg Phe Ser Gly Ser 
            180                 185                 190         


Gly Ser Gly Thr Asp Phe Thr Leu Thr Ile Ser Ser Leu Glu Ala Glu 
        195                 200                 205             


Asp Ala Ala Thr Tyr Tyr Cys Gln Gln Trp Ser Ser Asn Thr Leu Thr 
    210                 215                 220                 


Phe Gly Gln Gly Thr Lys Leu Glu Ile Lys 
225                 230                 


<210>  33
<211>  339
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthesized sequence

<400>  33

Cys Ala Gly Gly Thr Ala Cys Ala Ala Cys Thr Thr Cys Ala Gly Gly 
1               5                   10                  15      


Ala Gly Ala Gly Cys Gly Gly Gly Cys Cys Thr Gly Cys Thr Cys Thr 
            20                  25                  30          


Cys Gly Thr Gly Ala Ala Ala Cys Cys Cys Ala Cys Gly Cys Ala Ala 
        35                  40                  45              


Ala Cys Thr Cys Thr Thr Thr Cys Thr Ala Thr Thr Ala Cys Thr Thr 
    50                  55                  60                  


Gly Cys Ala Cys Gly Gly Thr Cys Thr Cys Ala Gly Gly Thr Thr Thr 
65                  70                  75                  80  


Thr Thr Cys Thr Cys Thr Gly Ala Thr Thr Thr Cys Ala Thr Ala Cys 
                85                  90                  95      


Gly Gly Thr Gly Thr Cys Ala Gly Thr Thr Gly Gly Gly Thr Ala Ala 
            100                 105                 110         


Gly Ala Cys Ala Ala Cys Cys Cys Cys Cys Gly Gly Gly Thr Ala Ala 
        115                 120                 125             


Ala Gly Cys Gly Thr Thr Gly Gly Ala Gly Thr Gly Gly Thr Thr Gly 
    130                 135                 140                 


Gly Gly Ala Gly Thr Ala Ala Thr Thr Thr Gly Gly Gly Gly Cys Gly 
145                 150                 155                 160 


Ala Cys Gly Gly Gly Thr Cys Thr Ala Cys Gly Ala Ala Thr Thr Ala 
                165                 170                 175     


Cys Cys Ala Cys Thr Cys Thr Ala Cys Ala Cys Thr Cys Ala Thr Ala 
            180                 185                 190         


Thr Cys Ala Ala Gly Ala Cys Thr Gly Thr Cys Cys Ala Thr Cys Ala 
        195                 200                 205             


Ala Thr Ala Ala Ala Gly Ala Thr Ala Cys Cys Thr Cys Thr Ala Ala 
    210                 215                 220                 


Ala Ala Ala Thr Cys Ala Ala Gly Thr Ala Thr Thr Thr Thr Thr Gly 
225                 230                 235                 240 


Ala Ala Ala Cys Thr Gly Ala Cys Cys Ala Ala Cys Ala Thr Gly Cys 
                245                 250                 255     


Ala Gly Ala Cys Ala Gly Ala Thr Gly Ala Thr Ala Cys Ala Gly Cys 
            260                 265                 270         


Cys Ala Cys Ala Thr Ala Thr Thr Ala Cys Thr Gly Thr Gly Thr Cys 
        275                 280                 285             


Gly Gly Gly Cys Cys Gly Ala Gly Gly Thr Thr Thr Gly Cys Gly Thr 
    290                 295                 300                 


Ala Thr Thr Gly Gly Gly Gly Gly Cys Ala Ala Gly Gly Thr Ala Cys 
305                 310                 315                 320 


Ala Thr Thr Gly Gly Thr Thr Ala Cys Cys Gly Thr Thr Ala Gly Thr 
                325                 330                 335     


Thr Cys Ala 
            


<210>  34
<211>  318
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Synthesized sequence

<400>  34
gaaattgtgc tgacccaatc cccagccact ctcagtctct cacccggcga aagagtaaca       60

atgacttgta gtgcgtccag ctccgtttct tacatgcact ggtatcagca gaaaccaggc      120

caggccccga aaaggtggat atatgatacc tctaaactga cctctggcat tcccgcccgc      180

tttagtggct ctggctcagg tacatcatac agtttgacta tatcctctct tgaggcagaa      240

gacgctgcga catattattg ccaacaatgg tctagcaata cgctcacctt cggccaaggg      300

acaaaactgg aaattaaa                                                    318


<210>  35
<211>  318
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Synthesized sequence

<400>  35
gaaattgtac tgactcagtc tccagctact ttgtctctct cccctgggga gcgggctacg       60

ctctcttgct cagcttcaag tagcgtgtcc tatatgcact ggtatcagca gaagccaggg      120

caggccccga aaagatggat ttatgacacc agtaaactta catccggaat ccccgcgcga      180

ttctctggaa gcggctcagg aaccgacttt acactcacga tttctagctt ggaagcagaa      240

gacgctgcga cctactattg ccaacaatgg tcttccaaca cgctcacgtt tggtcaagga      300

accaaactgg agataaaa                                                    318


<210>  36
<211>  702
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Synthesized sequence

<400>  36
caggtgcaac tgcaagagag tggcccagcc cttgttaaac ccacacagac tctcagtatt       60

acttgtacag tatccggctt cagtctcatc agttacgggg tatcctgggt gcgacaacca      120

ccgggtaaag cccttgaatg gctcggcgtt atatgggggg acggctctac gaattatcat      180

agcaccttga tttcccgcct tagtataaat aaggatacaa gcaaaaatca agtgttcttg      240

aaacttacga atatgcagac tgacgatacg gcgacctact actgtgtagg ccctcgattc      300

gcgtactggg gacagggaac attggttact gtttcatcag gaggtggcgg tagcggaggc      360

ggcggttctg gaggtggcgg gagcgaaatt gtgctgaccc aatccccagc cactctcagt      420

ctctcacccg gcgaaagagt aacaatgact tgtagtgcgt ccagctccgt ttcttacatg      480

cactggtatc agcagaaacc aggccaggcc ccgaaaaggt ggatatatga tacctctaaa      540

ctgacctctg gcattcccgc ccgctttagt ggctctggct caggtacatc atacagtttg      600

actatatcct ctcttgaggc agaagacgct gcgacatatt attgccaaca atggtctagc      660

aatacgctca ccttcggcca agggacaaaa ctggaaatta aa                         702


<210>  37
<211>  702
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Synthesized sequence

<400>  37
caggtacaac ttcaggagag cgggcctgct ctcgtgaaac ccacgcaaac tctttctatt       60

acttgcacgg tctcaggttt ttctctgatt tcatacggtg tcagttgggt aagacaaccc      120

ccgggtaaag cgttggagtg gttgggagta atttggggcg acgggtctac gaattaccac      180

tctacactca tatcaagact gtccatcaat aaagatacct ctaaaaatca agtatttttg      240

aaactgacca acatgcagac agatgataca gccacatatt actgtgtcgg gccgaggttt      300

gcgtattggg ggcaaggtac attggttacc gttagttcag gaggtggcgg tagcggaggc      360

ggcggttctg gaggtggcgg gagcgaaatt gtactgactc agtctccagc tactttgtct      420

ctctcccctg gggagcgggc tacgctctct tgctcagctt caagtagcgt gtcctatatg      480

cactggtatc agcagaagcc agggcaggcc ccgaaaagat ggatttatga caccagtaaa      540

cttacatccg gaatccccgc gcgattctct ggaagcggct caggaaccga ctttacactc      600

acgatttcta gcttggaagc agaagacgct gcgacctact attgccaaca atggtcttcc      660

aacacgctca cgtttggtca aggaaccaaa ctggagataa aa                         702


<210>  38
<211>  339
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Synthesized sequence

<400>  38
caggtcacct tgagggagtc tggtcctgcg ctggtgaaac ccacacagac cctcaccctg       60

acctgcacct tctctgggtt ctcactcatc agctatggtg taagctgggt ccgtcagccc      120

ccagggaagg ccctggagtg gcttggagta atatggggtg acgggagcac aaattatcat      180

tcaactctca tatccaggct caccatctcc aaggacacct ccaaaaacca ggtggtcctt      240

acaatgacca acatggaccc tgtggacaca gccacgtatt actgtgtcgg accccggttt      300

gcttactggg gccagggcac cctggtcacc gtctcctca                             339


<210>  39
<211>  339
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Synthesized sequence

<400>  39
caggtgcagc tgcaggagtc gggcccagga ctggtgaagc cttcggagac cctgtccctc       60

acctgcactg tctctggtgg ctccatcagt agctatggtg taagctggat ccggcagccc      120

ccagggaagg gactggagtg gattggggta atatggggtg acgggagcac aaattatcat      180

tcaactctca tatcccgagt caccatatcc gtagacacgt ccaagaacca gttctccctg      240

aagctgagct ctgtgaccgc cgcagacacg gccgtgtatt actgtgtcgg accccggttt      300

gcttactggg gccagggcac cctggtcacc gtctcctca                             339


<210>  40
<211>  318
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Synthesized sequence

<400>  40
gaaattgtgt tgacacagtc tccagccacc ctgtctttgt ctccagggga aagagccacc       60

ctctcctgca gtgccagctc aagtgtaagt tacatgcact ggtaccaaca gaaacctggc      120

caggctccca ggctcctcat ctatgacaca tccaaactga cttctggcat cccagccagg      180

ttcagtggca gtgggtctgg gacagacttc actctcacca tcagcagcct agagcctgaa      240

gattttgcag tttattactg tcagcagtgg agtagtaata cgctcacgtt tggccagggg      300

accaagctgg agatcaaa                                                    318


<210>  41
<211>  414
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthesized sequence

<400>  41

Met Asp Phe Gln Val Gln Ile Phe Ser Phe Leu Leu Ile Ser Ala Ser 
1               5                   10                  15      


Val Ile Met Ser Arg Gly Gln Val Gln Leu Gln Glu Ser Gly Pro Ala 
            20                  25                  30          


Leu Val Lys Pro Thr Gln Thr Leu Ser Ile Thr Cys Thr Val Ser Gly 
        35                  40                  45              


Phe Ser Leu Ile Ser Tyr Gly Val Ser Trp Val Arg Gln Pro Pro Gly 
    50                  55                  60                  


Lys Ala Leu Glu Trp Leu Gly Val Ile Trp Gly Asp Gly Ser Thr Asn 
65                  70                  75                  80  


Tyr His Ser Thr Leu Ile Ser Arg Leu Ser Ile Asn Lys Asp Thr Ser 
                85                  90                  95      


Lys Asn Gln Val Phe Leu Lys Leu Thr Asn Met Gln Thr Asp Asp Thr 
            100                 105                 110         


Ala Thr Tyr Tyr Cys Val Gly Pro Arg Phe Ala Tyr Trp Gly Gln Gly 
        115                 120                 125             


Thr Leu Val Thr Val Ser Ser Gly Gly Gly Gly Ser Gly Gly Gly Gly 
    130                 135                 140                 


Ser Gly Gly Gly Gly Ser Glu Ile Val Leu Thr Gln Ser Pro Ala Thr 
145                 150                 155                 160 


Leu Ser Leu Ser Pro Gly Glu Arg Val Thr Met Thr Cys Ser Ala Ser 
                165                 170                 175     


Ser Ser Val Ser Tyr Met His Trp Tyr Gln Gln Lys Pro Gly Gln Ala 
            180                 185                 190         


Pro Lys Arg Trp Ile Tyr Asp Thr Ser Lys Leu Thr Ser Gly Ile Pro 
        195                 200                 205             


Ala Arg Phe Ser Gly Ser Gly Ser Gly Thr Ser Tyr Ser Leu Thr Ile 
    210                 215                 220                 


Ser Ser Leu Glu Ala Glu Asp Ala Ala Thr Tyr Tyr Cys Gln Gln Trp 
225                 230                 235                 240 


Ser Ser Asn Thr Leu Thr Phe Gly Gln Gly Thr Lys Leu Glu Ile Lys 
                245                 250                 255     


Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser Ala Ala Ala Ile Glu Val 
            260                 265                 270         


Met Tyr Pro Pro Pro Tyr Leu Asp Asn Glu Lys Ser Asn Gly Thr Ile 
        275                 280                 285             


Ile His Val Lys Gly Lys His Leu Cys Pro Ser Pro Leu Phe Pro Gly 
    290                 295                 300                 


Pro Ser Lys Pro Phe Trp Val Leu Val Val Val Gly Gly Val Leu Ala 
305                 310                 315                 320 


Cys Tyr Ser Leu Leu Val Thr Val Ala Phe Ile Ile Phe Trp Val Arg 
                325                 330                 335     


Ser Lys Arg Ser Arg Leu Leu His Ser Asp Tyr Met Asn Met Thr Pro 
            340                 345                 350         


Arg Arg Pro Gly Pro Thr Arg Lys His Tyr Gln Pro Tyr Ala Pro Pro 
        355                 360                 365             


Arg Asp Phe Ala Ala Tyr Arg Ser Gln Val Arg Lys Ala Ala Ile Thr 
    370                 375                 380                 


Ser Tyr Glu Lys Ser Asp Gly Val Tyr Thr Gly Leu Ser Thr Arg Asn 
385                 390                 395                 400 


Gln Glu Thr Tyr Glu Thr Leu Lys His Glu Lys Pro Pro Gln 
                405                 410                 


<210>  42
<211>  414
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthesized sequence

<400>  42

Met Asp Phe Gln Val Gln Ile Phe Ser Phe Leu Leu Ile Ser Ala Ser 
1               5                   10                  15      


Val Ile Met Ser Arg Gly Gln Val Gln Leu Gln Glu Ser Gly Pro Ala 
            20                  25                  30          


Leu Val Lys Pro Thr Gln Thr Leu Ser Ile Thr Cys Thr Val Ser Gly 
        35                  40                  45              


Phe Ser Leu Ile Ser Tyr Gly Val Ser Trp Val Arg Gln Pro Pro Gly 
    50                  55                  60                  


Lys Ala Leu Glu Trp Leu Gly Val Ile Trp Gly Asp Gly Ser Thr Asn 
65                  70                  75                  80  


Tyr His Ser Thr Leu Ile Ser Arg Leu Ser Ile Asn Lys Asp Thr Ser 
                85                  90                  95      


Lys Asn Gln Val Phe Leu Lys Leu Thr Asn Met Gln Thr Asp Asp Thr 
            100                 105                 110         


Ala Thr Tyr Tyr Cys Val Gly Pro Arg Phe Ala Tyr Trp Gly Gln Gly 
        115                 120                 125             


Thr Leu Val Thr Val Ser Ser Gly Gly Gly Gly Ser Gly Gly Gly Gly 
    130                 135                 140                 


Ser Gly Gly Gly Gly Ser Glu Ile Val Leu Thr Gln Ser Pro Ala Thr 
145                 150                 155                 160 


Leu Ser Leu Ser Pro Gly Glu Arg Ala Thr Leu Ser Cys Ser Ala Ser 
                165                 170                 175     


Ser Ser Val Ser Tyr Met His Trp Tyr Gln Gln Lys Pro Gly Gln Ala 
            180                 185                 190         


Pro Lys Arg Trp Ile Tyr Asp Thr Ser Lys Leu Thr Ser Gly Ile Pro 
        195                 200                 205             


Ala Arg Phe Ser Gly Ser Gly Ser Gly Thr Asp Phe Thr Leu Thr Ile 
    210                 215                 220                 


Ser Ser Leu Glu Ala Glu Asp Ala Ala Thr Tyr Tyr Cys Gln Gln Trp 
225                 230                 235                 240 


Ser Ser Asn Thr Leu Thr Phe Gly Gln Gly Thr Lys Leu Glu Ile Lys 
                245                 250                 255     


Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser Ala Ala Ala Ile Glu Val 
            260                 265                 270         


Met Tyr Pro Pro Pro Tyr Leu Asp Asn Glu Lys Ser Asn Gly Thr Ile 
        275                 280                 285             


Ile His Val Lys Gly Lys His Leu Cys Pro Ser Pro Leu Phe Pro Gly 
    290                 295                 300                 


Pro Ser Lys Pro Phe Trp Val Leu Val Val Val Gly Gly Val Leu Ala 
305                 310                 315                 320 


Cys Tyr Ser Leu Leu Val Thr Val Ala Phe Ile Ile Phe Trp Val Arg 
                325                 330                 335     


Ser Lys Arg Ser Arg Leu Leu His Ser Asp Tyr Met Asn Met Thr Pro 
            340                 345                 350         


Arg Arg Pro Gly Pro Thr Arg Lys His Tyr Gln Pro Tyr Ala Pro Pro 
        355                 360                 365             


Arg Asp Phe Ala Ala Tyr Arg Ser Gln Val Arg Lys Ala Ala Ile Thr 
    370                 375                 380                 


Ser Tyr Glu Lys Ser Asp Gly Val Tyr Thr Gly Leu Ser Thr Arg Asn 
385                 390                 395                 400 


Gln Glu Thr Tyr Glu Thr Leu Lys His Glu Lys Pro Pro Gln 
                405                 410                 


<210>  43
<211>  1245
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Synthesized sequence

<400>  43
atggattttc aggtgcagat tttcagcttc ctgctaatca gtgcctcagt cataatgtcc       60

agaggacagg tgcaactgca agagagtggc ccagcccttg ttaaacccac acagactctc      120

agtattactt gtacagtatc cggcttcagt ctcatcagtt acggggtatc ctgggtgcga      180

caaccaccgg gtaaagccct tgaatggctc ggcgttatat ggggggacgg ctctacgaat      240

tatcatagca ccttgatttc ccgccttagt ataaataagg atacaagcaa aaatcaagtg      300

ttcttgaaac ttacgaatat gcagactgac gatacggcga cctactactg tgtaggccct      360

cgattcgcgt actggggaca gggaacattg gttactgttt catcaggagg tggcggtagc      420

ggaggcggcg gttctggagg tggcgggagc gaaattgtgc tgacccaatc cccagccact      480

ctcagtctct cacccggcga aagagtaaca atgacttgta gtgcgtccag ctccgtttct      540

tacatgcact ggtatcagca gaaaccaggc caggccccga aaaggtggat atatgatacc      600

tctaaactga cctctggcat tcccgcccgc tttagtggct ctggctcagg tacatcatac      660

agtttgacta tatcctctct tgaggcagaa gacgctgcga catattattg ccaacaatgg      720

tctagcaata cgctcacctt cggccaaggg acaaaactgg aaattaaagg aggtggcggt      780

agcggaggcg gcggttctgc ggccgcaatt gaagttatgt atcctcctcc ttacctagac      840

aatgagaaga gcaatggaac cattatccat gtgaaaggga aacacctttg tccaagtccc      900

ctatttcccg gaccttctaa gcccttttgg gtgctggtgg tggttggtgg agtcctggct      960

tgctatagct tgctagtaac agtggccttt attattttct gggtgaggag taagaggagc     1020

aggctcctgc acagtgacta catgaacatg actccccgcc gccccgggcc cacccgcaag     1080

cattaccagc cctatgcccc accacgcgac ttcgcagcct atagatctca agtgcgaaag     1140

gcagctataa ccagctatga gaaatcagat ggtgtttaca cgggcctgag caccaggaac     1200

caggagactt acgagactct gaagcatgag aaaccaccac agtag                     1245


<210>  44
<211>  1245
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Synthesized sequence

<400>  44
atggattttc aggtgcagat tttcagcttc ctgctaatca gtgcctcagt cataatgtcc       60

agaggacagg tacaacttca ggagagcggg cctgctctcg tgaaacccac gcaaactctt      120

tctattactt gcacggtctc aggtttttct ctgatttcat acggtgtcag ttgggtaaga      180

caacccccgg gtaaagcgtt ggagtggttg ggagtaattt ggggcgacgg gtctacgaat      240

taccactcta cactcatatc aagactgtcc atcaataaag atacctctaa aaatcaagta      300

tttttgaaac tgaccaacat gcagacagat gatacagcca catattactg tgtcgggccg      360

aggtttgcgt attgggggca aggtacattg gttaccgtta gttcaggagg tggcggtagc      420

ggaggcggcg gttctggagg tggcgggagc gaaattgtac tgactcagtc tccagctact      480

ttgtctctct cccctgggga gcgggctacg ctctcttgct cagcttcaag tagcgtgtcc      540

tatatgcact ggtatcagca gaagccaggg caggccccga aaagatggat ttatgacacc      600

agtaaactta catccggaat ccccgcgcga ttctctggaa gcggctcagg aaccgacttt      660

acactcacga tttctagctt ggaagcagaa gacgctgcga cctactattg ccaacaatgg      720

tcttccaaca cgctcacgtt tggtcaagga accaaactgg agataaaagg aggtggcggt      780

agcggaggcg gcggttctgc ggccgcaatt gaagttatgt atcctcctcc ttacctagac      840

aatgagaaga gcaatggaac cattatccat gtgaaaggga aacacctttg tccaagtccc      900

ctatttcccg gaccttctaa gcccttttgg gtgctggtgg tggttggtgg agtcctggct      960

tgctatagct tgctagtaac agtggccttt attattttct gggtgaggag taagaggagc     1020

aggctcctgc acagtgacta catgaacatg actccccgcc gccccgggcc cacccgcaag     1080

cattaccagc cctatgcccc accacgcgac ttcgcagcct atagatctca agtgcgaaag     1140

gcagctataa ccagctatga gaaatcagat ggtgtttaca cgggcctgag caccaggaac     1200

caggagactt acgagactct gaagcatgag aaaccaccac agtag                     1245


<210>  45
<211>  339
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Synthesized sequence

<400>  45
caggtgcaac tgcaagagag tggcccagcc cttgttaaac ccacacagac tctcagtatt       60

acttgtacag tatccggctt cagtctcatc agttacgggg tatcctgggt gcgacaacca      120

ccgggtaaag cccttgaatg gctcggcgtt atatgggggg acggctctac gaattatcat      180

agcaccttga tttcccgcct tagtataaat aaggatacaa gcaaaaatca agtgttcttg      240

aaacttacga atatgcagac tgacgatacg gcgacctact actgtgtagg ccctcgattc      300

gcgtactggg gacagggaac attggttact gtttcatca                             339


<210>  46
<211>  8
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthesized sequence

<400>  46

Trp Ser His Pro Gln Phe Glu Lys 
1               5               


<210>  47
<211>  24
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Synthesized sequence

<400>  47
tggagccacc cgcagttcga gaaa                                              24


<210>  48
<211>  422
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthesized sequence

<400>  48

Met Asp Phe Gln Val Gln Ile Phe Ser Phe Leu Leu Ile Ser Ala Ser 
1               5                   10                  15      


Val Ile Met Ser Arg Gly Gln Val Gln Leu Gln Glu Ser Gly Pro Ala 
            20                  25                  30          


Leu Val Lys Pro Thr Gln Thr Leu Ser Ile Thr Cys Thr Val Ser Gly 
        35                  40                  45              


Phe Ser Leu Ile Ser Tyr Gly Val Ser Trp Val Arg Gln Pro Pro Gly 
    50                  55                  60                  


Lys Ala Leu Glu Trp Leu Gly Val Ile Trp Gly Asp Gly Ser Thr Asn 
65                  70                  75                  80  


Tyr His Ser Thr Leu Ile Ser Arg Leu Ser Ile Asn Lys Asp Thr Ser 
                85                  90                  95      


Lys Asn Gln Val Phe Leu Lys Leu Thr Asn Met Gln Thr Asp Asp Thr 
            100                 105                 110         


Ala Thr Tyr Tyr Cys Val Gly Pro Arg Phe Ala Tyr Trp Gly Gln Gly 
        115                 120                 125             


Thr Leu Val Thr Val Ser Ser Gly Gly Gly Gly Ser Gly Gly Gly Gly 
    130                 135                 140                 


Ser Gly Gly Gly Gly Ser Glu Ile Val Leu Thr Gln Ser Pro Ala Thr 
145                 150                 155                 160 


Leu Ser Leu Ser Pro Gly Glu Arg Val Thr Met Thr Cys Ser Ala Ser 
                165                 170                 175     


Ser Ser Val Ser Tyr Met His Trp Tyr Gln Gln Lys Pro Gly Gln Ala 
            180                 185                 190         


Pro Lys Arg Trp Ile Tyr Asp Thr Ser Lys Leu Thr Ser Gly Ile Pro 
        195                 200                 205             


Ala Arg Phe Ser Gly Ser Gly Ser Gly Thr Ser Tyr Ser Leu Thr Ile 
    210                 215                 220                 


Ser Ser Leu Glu Ala Glu Asp Ala Ala Thr Tyr Tyr Cys Gln Gln Trp 
225                 230                 235                 240 


Ser Ser Asn Thr Leu Thr Phe Gly Gln Gly Thr Lys Leu Glu Ile Lys 
                245                 250                 255     


Trp Ser His Pro Gln Phe Glu Lys Gly Gly Gly Gly Ser Gly Gly Gly 
            260                 265                 270         


Gly Ser Ala Ala Ala Ile Glu Val Met Tyr Pro Pro Pro Tyr Leu Asp 
        275                 280                 285             


Asn Glu Lys Ser Asn Gly Thr Ile Ile His Val Lys Gly Lys His Leu 
    290                 295                 300                 


Cys Pro Ser Pro Leu Phe Pro Gly Pro Ser Lys Pro Phe Trp Val Leu 
305                 310                 315                 320 


Val Val Val Gly Gly Val Leu Ala Cys Tyr Ser Leu Leu Val Thr Val 
                325                 330                 335     


Ala Phe Ile Ile Phe Trp Val Arg Ser Lys Arg Ser Arg Leu Leu His 
            340                 345                 350         


Ser Asp Tyr Met Asn Met Thr Pro Arg Arg Pro Gly Pro Thr Arg Lys 
        355                 360                 365             


His Tyr Gln Pro Tyr Ala Pro Pro Arg Asp Phe Ala Ala Tyr Arg Ser 
    370                 375                 380                 


Gln Val Arg Lys Ala Ala Ile Thr Ser Tyr Glu Lys Ser Asp Gly Val 
385                 390                 395                 400 


Tyr Thr Gly Leu Ser Thr Arg Asn Gln Glu Thr Tyr Glu Thr Leu Lys 
                405                 410                 415     


His Glu Lys Pro Pro Gln 
            420         


<210>  49
<211>  422
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthesized sequence

<400>  49

Met Asp Phe Gln Val Gln Ile Phe Ser Phe Leu Leu Ile Ser Ala Ser 
1               5                   10                  15      


Val Ile Met Ser Arg Gly Gln Val Gln Leu Gln Glu Ser Gly Pro Ala 
            20                  25                  30          


Leu Val Lys Pro Thr Gln Thr Leu Ser Ile Thr Cys Thr Val Ser Gly 
        35                  40                  45              


Phe Ser Leu Ile Ser Tyr Gly Val Ser Trp Val Arg Gln Pro Pro Gly 
    50                  55                  60                  


Lys Ala Leu Glu Trp Leu Gly Val Ile Trp Gly Asp Gly Ser Thr Asn 
65                  70                  75                  80  


Tyr His Ser Thr Leu Ile Ser Arg Leu Ser Ile Asn Lys Asp Thr Ser 
                85                  90                  95      


Lys Asn Gln Val Phe Leu Lys Leu Thr Asn Met Gln Thr Asp Asp Thr 
            100                 105                 110         


Ala Thr Tyr Tyr Cys Val Gly Pro Arg Phe Ala Tyr Trp Gly Gln Gly 
        115                 120                 125             


Thr Leu Val Thr Val Ser Ser Gly Gly Gly Gly Ser Gly Gly Gly Gly 
    130                 135                 140                 


Ser Gly Gly Gly Gly Ser Glu Ile Val Leu Thr Gln Ser Pro Ala Thr 
145                 150                 155                 160 


Leu Ser Leu Ser Pro Gly Glu Arg Ala Thr Leu Ser Cys Ser Ala Ser 
                165                 170                 175     


Ser Ser Val Ser Tyr Met His Trp Tyr Gln Gln Lys Pro Gly Gln Ala 
            180                 185                 190         


Pro Lys Arg Trp Ile Tyr Asp Thr Ser Lys Leu Thr Ser Gly Ile Pro 
        195                 200                 205             


Ala Arg Phe Ser Gly Ser Gly Ser Gly Thr Asp Phe Thr Leu Thr Ile 
    210                 215                 220                 


Ser Ser Leu Glu Ala Glu Asp Ala Ala Thr Tyr Tyr Cys Gln Gln Trp 
225                 230                 235                 240 


Ser Ser Asn Thr Leu Thr Phe Gly Gln Gly Thr Lys Leu Glu Ile Lys 
                245                 250                 255     


Trp Ser His Pro Gln Phe Glu Lys Gly Gly Gly Gly Ser Gly Gly Gly 
            260                 265                 270         


Gly Ser Ala Ala Ala Ile Glu Val Met Tyr Pro Pro Pro Tyr Leu Asp 
        275                 280                 285             


Asn Glu Lys Ser Asn Gly Thr Ile Ile His Val Lys Gly Lys His Leu 
    290                 295                 300                 


Cys Pro Ser Pro Leu Phe Pro Gly Pro Ser Lys Pro Phe Trp Val Leu 
305                 310                 315                 320 


Val Val Val Gly Gly Val Leu Ala Cys Tyr Ser Leu Leu Val Thr Val 
                325                 330                 335     


Ala Phe Ile Ile Phe Trp Val Arg Ser Lys Arg Ser Arg Leu Leu His 
            340                 345                 350         


Ser Asp Tyr Met Asn Met Thr Pro Arg Arg Pro Gly Pro Thr Arg Lys 
        355                 360                 365             


His Tyr Gln Pro Tyr Ala Pro Pro Arg Asp Phe Ala Ala Tyr Arg Ser 
    370                 375                 380                 


Gln Val Arg Lys Ala Ala Ile Thr Ser Tyr Glu Lys Ser Asp Gly Val 
385                 390                 395                 400 


Tyr Thr Gly Leu Ser Thr Arg Asn Gln Glu Thr Tyr Glu Thr Leu Lys 
                405                 410                 415     


His Glu Lys Pro Pro Gln 
            420         


<210>  50
<211>  1269
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Synthesized sequence

<400>  50
atggattttc aggtgcagat tttcagcttc ctgctaatca gtgcctcagt cataatgtcc       60

agaggacagg tgcaactgca agagagtggc ccagcccttg ttaaacccac acagactctc      120

agtattactt gtacagtatc cggcttcagt ctcatcagtt acggggtatc ctgggtgcga      180

caaccaccgg gtaaagccct tgaatggctc ggcgttatat ggggggacgg ctctacgaat      240

tatcatagca ccttgatttc ccgccttagt ataaataagg atacaagcaa aaatcaagtg      300

ttcttgaaac ttacgaatat gcagactgac gatacggcga cctactactg tgtaggccct      360

cgattcgcgt actggggaca gggaacattg gttactgttt catcaggagg tggcggtagc      420

ggaggcggcg gttctggagg tggcgggagc gaaattgtgc tgacccaatc cccagccact      480

ctcagtctct cacccggcga aagagtaaca atgacttgta gtgcgtccag ctccgtttct      540

tacatgcact ggtatcagca gaaaccaggc caggccccga aaaggtggat atatgatacc      600

tctaaactga cctctggcat tcccgcccgc tttagtggct ctggctcagg tacatcatac      660

agtttgacta tatcctctct tgaggcagaa gacgctgcga catattattg ccaacaatgg      720

tctagcaata cgctcacctt cggccaaggg acaaaactgg aaattaaatg gagccacccg      780

cagttcgaga aaggaggtgg cggtagcgga ggcggcggtt ctgcggccgc aattgaagtt      840

atgtatcctc ctccttacct agacaatgag aagagcaatg gaaccattat ccatgtgaaa      900

gggaaacacc tttgtccaag tcccctattt cccggacctt ctaagccctt ttgggtgctg      960

gtggtggttg gtggagtcct ggcttgctat agcttgctag taacagtggc ctttattatt     1020

ttctgggtga ggagtaagag gagcaggctc ctgcacagtg actacatgaa catgactccc     1080

cgccgccccg ggcccacccg caagcattac cagccctatg ccccaccacg cgacttcgca     1140

gcctatagat ctcaagtgcg aaaggcagct ataaccagct atgagaaatc agatggtgtt     1200

tacacgggcc tgagcaccag gaaccaggag acttacgaga ctctgaagca tgagaaacca     1260

ccacagtag                                                             1269


<210>  51
<211>  1269
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Synthesized sequence

<400>  51
atggattttc aggtgcagat tttcagcttc ctgctaatca gtgcctcagt cataatgtcc       60

agaggacagg tacaacttca ggagagcggg cctgctctcg tgaaacccac gcaaactctt      120

tctattactt gcacggtctc aggtttttct ctgatttcat acggtgtcag ttgggtaaga      180

caacccccgg gtaaagcgtt ggagtggttg ggagtaattt ggggcgacgg gtctacgaat      240

taccactcta cactcatatc aagactgtcc atcaataaag atacctctaa aaatcaagta      300

tttttgaaac tgaccaacat gcagacagat gatacagcca catattactg tgtcgggccg      360

aggtttgcgt attgggggca aggtacattg gttaccgtta gttcaggagg tggcggtagc      420

ggaggcggcg gttctggagg tggcgggagc gaaattgtac tgactcagtc tccagctact      480

ttgtctctct cccctgggga gcgggctacg ctctcttgct cagcttcaag tagcgtgtcc      540

tatatgcact ggtatcagca gaagccaggg caggccccga aaagatggat ttatgacacc      600

agtaaactta catccggaat ccccgcgcga ttctctggaa gcggctcagg aaccgacttt      660

acactcacga tttctagctt ggaagcagaa gacgctgcga cctactattg ccaacaatgg      720

tcttccaaca cgctcacgtt tggtcaagga accaaactgg agataaaatg gagccacccg      780

cagttcgaga aaggaggtgg cggtagcgga ggcggcggtt ctgcggccgc aattgaagtt      840

atgtatcctc ctccttacct agacaatgag aagagcaatg gaaccattat ccatgtgaaa      900

gggaaacacc tttgtccaag tcccctattt cccggacctt ctaagccctt ttgggtgctg      960

gtggtggttg gtggagtcct ggcttgctat agcttgctag taacagtggc ctttattatt     1020

ttctgggtga ggagtaagag gagcaggctc ctgcacagtg actacatgaa catgactccc     1080

cgccgccccg ggcccacccg caagcattac cagccctatg ccccaccacg cgacttcgca     1140

gcctatagat ctcaagtgcg aaaggcagct ataaccagct atgagaaatc agatggtgtt     1200

tacacgggcc tgagcaccag gaaccaggag acttacgaga ctctgaagca tgagaaacca     1260

ccacagtag                                                             1269


