                         SEQUENCE LISTING

<110>  National Research Council of Canada
 
<120>  Antibodies that bind SARS-CoV-2 spike protein

<130>  2021-044-02

<150>  CA 3115877
<151>  2021-04-22

<160>  186   

<170>  PatentIn version 3.5

<210>  1
<211>  8
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  CDR1, NRCoV2-1a and NRCoV2-1d

<400>  1

Gly Ser Thr Leu Asp Tyr Tyr Ala 
1               5               


<210>  2
<211>  8
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  CDR1, NRCoV2-1c

<400>  2

Gly Ser Ile Leu Asp Tyr Tyr Ala 
1               5               


<210>  3
<211>  8
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  CDR1, NRCoV2-02

<400>  3

Gly Phe Thr Phe Ser Asn Tyr Ala 
1               5               


<210>  4
<211>  8
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  CDR1, NRCoV2-03

<400>  4

Gly Ile Thr Phe Ser Tyr Tyr Ala 
1               5               


<210>  5
<211>  8
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  CDR1, NRCoV2-04

<400>  5

Gly Ser Pro Phe Ser Asn Val Val 
1               5               


<210>  6
<211>  8
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  CDR1, NRCoV2-05

<400>  6

Gly Phe Ile Phe Ser Asn Tyr Ala 
1               5               


<210>  7
<211>  8
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  CDR1, NRCoV2-06

<400>  7

Val Ser Thr Phe Ser Ser Tyr Ala 
1               5               


<210>  8
<211>  8
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  CDR1, NRCoV2-07

<400>  8

Gly Val Thr Leu Asp Tyr Tyr Ala 
1               5               


<210>  9
<211>  8
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  CDR1, NRCoV2-08

<400>  9

Gly Phe Thr Leu Asp Asp Tyr Ala 
1               5               


<210>  10
<211>  8
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  CDR1, NRCoV2-10

<400>  10

Gly Asn Thr Phe Ser Arg Ser Asn 
1               5               


<210>  11
<211>  8
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  CDR1, NRCoV2-11

<400>  11

Gly Ser Ser Leu Asp Ser Tyr Ser 
1               5               


<210>  12
<211>  8
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  CDR1, NRCoV2-11a

<400>  12

Gly Phe Thr Leu Asp Ser Tyr Asn 
1               5               


<210>  13
<211>  8
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  CDR1, NRCoV2-12

<400>  13

Gly Arg Thr Phe Arg Asn Tyr Val 
1               5               


<210>  14
<211>  8
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  CDR1, NRCoV2-14

<400>  14

Gly Thr Thr Phe Ser His Tyr Ala 
1               5               


<210>  15
<211>  8
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  CDR1, NRCoV2-15

<400>  15

Gly Ser Thr Ser Gly Arg Asn Thr 
1               5               


<210>  16
<211>  8
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  CDR1, NRCoV2-17

<400>  16

Gly Ser Pro Phe Ser Gln Leu Ala 
1               5               


<210>  17
<211>  8
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  CDR1, NRCoV2-18

<400>  17

Gly Ile Thr Ile Ser Gly Tyr Asn 
1               5               


<210>  18
<211>  8
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  CDR1, NRCoV2-19

<400>  18

Gly Leu Thr Leu Asn Ser Tyr Ala 
1               5               


<210>  19
<211>  8
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  CDR1, NRCoV2-20

<400>  19

Gly Arg Thr Phe Ser Asn Tyr Val 
1               5               


<210>  20
<211>  8
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  CDR1, NRCoV2-21, NRCoV2-MRed03, and NRCoV2-MRed05

<400>  20

Gly Phe Thr Leu Asp Tyr Tyr Ala 
1               5               


<210>  21
<211>  8
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  CDR1, NRCoV2-SR01

<400>  21

Gly Phe Thr Phe Asp Asn Tyr Ala 
1               5               


<210>  22
<211>  8
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  CDR1, NRCoV2-SR02

<400>  22

Glu Phe Thr Leu Asn Tyr Tyr Ser 
1               5               


<210>  23
<211>  8
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  CDR1, NRCoV2-SR03

<400>  23

Gly Ser Ile Phe Ser Asn Asn His 
1               5               


<210>  24
<211>  8
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  CDR1, NRCoV2-SR04

<400>  24

Gly Arg Thr Phe Ser Ser His Thr 
1               5               


<210>  25
<211>  8
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  CDR1, NRCoV2-SR13

<400>  25

Gly Ser Arg Phe Gly Ser Lys His 
1               5               


<210>  26
<211>  8
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  CDR1, NRCoV2-SR16

<400>  26

Gly Thr Thr Phe Ser Arg Tyr His 
1               5               


<210>  27
<211>  8
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  CDR1, NRCoV2-S2A3

<400>  27

Gly Arg Pro Tyr Ser Asn Tyr Ala 
1               5               


<210>  28
<211>  8
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  CDR1, NRCoV2-S2A4

<400>  28

Gly Ser Pro Phe Arg Ser Asn Val 
1               5               


<210>  29
<211>  8
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  CDR1, NRCoV2-S2B3

<400>  29

Ala Ser Thr Phe Gly Asp Ser Ala 
1               5               


<210>  30
<211>  8
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  CDR1, NRCoV2-S2H4

<400>  30

Gly Phe Thr Phe Asn Leu Tyr Ser 
1               5               


<210>  31
<211>  8
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  CDR1, NRCoV2-S2F3

<400>  31

Val Arg Ile Leu Ser Val Pro Ala 
1               5               


<210>  32
<211>  8
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  CDR1, NRCoV2-S2G3

<400>  32

Gly Ser Thr Phe Gly Ile Phe Leu 
1               5               


<210>  33
<211>  8
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  CDR1, NRCoV2-S2G4

<400>  33

Gly Ser Thr Phe Ser Gly Tyr Ala 
1               5               


<210>  34
<211>  8
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  CDR1, NRCoV2-S202

<400>  34

Gly Ile Thr Val Ser Arg Ile Gly 
1               5               


<210>  35
<211>  8
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  CDR1, NRCoV2-MRed02

<400>  35

Gly Asn Ile Phe Ser Ile Asn Ser 
1               5               


<210>  36
<211>  8
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  CDR1, NRCoV2-MRed04

<400>  36

Gly Asn Ser Phe Ser Ile Asn Thr 
1               5               


<210>  37
<211>  8
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  CDR1, NRCoV2-MRed06

<400>  37

Gly Phe Thr Leu Ala Tyr Tyr Ala 
1               5               


<210>  38
<211>  8
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  CDR1, NRCoV2-MRed07

<400>  38

Gly Ser Ile Gly Pro Phe Asn Thr 
1               5               


<210>  39
<211>  8
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  CDR1, NRCoV2-MRed11

<400>  39

Gly Phe Thr Phe Ser Ser Tyr Ala 
1               5               


<210>  40
<211>  8
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  CDR1, NRCoV2-MRed18

<400>  40

Thr Thr Val Phe Gly Arg Asn Ala 
1               5               


<210>  41
<211>  8
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  CDR1, NRCoV2-MRed19

<400>  41

Thr Ile Ile Phe Lys Gly Gln Thr 
1               5               


<210>  42
<211>  8
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  CDR1, NRCoV2-MRed20

<400>  42

Gly Leu Ser Phe Ser Ser Tyr Asp 
1               5               


<210>  43
<211>  8
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  CDR1, NRCoV2-MRed22

<400>  43

Gly Ser Val Phe Ala Ser Asn Ala 
1               5               


<210>  44
<211>  8
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  CDR1, NRCoV2-MRed25

<400>  44

Gly His Thr Phe Ser Arg Tyr Gly 
1               5               


<210>  45
<211>  8
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  CDR2, NRCoV2-1a and  NRCoV2-1c

<400>  45

Val Ser Ser Ser Asp Gly Ser Thr 
1               5               


<210>  46
<211>  8
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  CDR2, NRCoV2-1d

<400>  46

Val Ser Ser Ser Asp Gly Asn Thr 
1               5               


<210>  47
<211>  8
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  CDR2, NRCoV2-02

<400>  47

Ile Ser Gly Arg Gly Asp Asp Thr 
1               5               


<210>  48
<211>  7
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  CDR2, NRCoV2-03

<400>  48

Met Ser Asn Met Asp Ser Thr 
1               5           


<210>  49
<211>  7
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  CDR2, NRCoV2-04

<400>  49

Ile Ser Gly Gly Gly Ile Ala 
1               5           


<210>  50
<211>  8
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  CDR2, NRCoV2-05

<400>  50

Ile Asn Ser Gly Gly Gly Asp Thr 
1               5               


<210>  51
<211>  7
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  CDR2, NRCoV2-06

<400>  51

Ile Gly Phe Val Gly Ala Thr 
1               5           


<210>  52
<211>  8
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  CDR2, NRCoV2-07

<400>  52

Ile Ser Ser Asn Gly Arg Arg Asn 
1               5               


<210>  53
<211>  8
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  CDR2, NRCoV2-08

<400>  53

Ile Ser Arg Ser Gly Thr Thr Thr 
1               5               


<210>  54
<211>  7
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  CDR2, NRCoV2-10

<400>  54

Ile Ser Ser Arg Gly Ile Ser 
1               5           


<210>  55
<211>  8
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  CDR2, NRCoV2-11

<400>  55

Ile Ser Arg Tyr Tyr Ser Ser Thr 
1               5               


<210>  56
<211>  8
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  CDR2, NRCoV2-11a

<400>  56

Ile Ser Arg Tyr Tyr Glu Ser Thr 
1               5               


<210>  57
<211>  11
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  CDR2, NRCoV2-12

<400>  57

Val Ala Ala Ile Ser Trp Gly Gly Thr Glu Ile 
1               5                   10      


<210>  58
<211>  7
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  CDR2, NRCoV2-14

<400>  58

Ile Ser Val Phe Gly Ser Thr 
1               5           


<210>  59
<211>  7
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  CDR2, NRCoV2-15

<400>  59

Val Ser Thr Ser Gly Ala Thr 
1               5           


<210>  60
<211>  7
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  CDR2, NRCoV2-17

<400>  60

Ile Ser Pro Thr Gly Asn Arg 
1               5           


<210>  61
<211>  7
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  CDR2, NRCoV2-18

<400>  61

Ile Asn Ser Gly Gly Ser Thr 
1               5           


<210>  62
<211>  7
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  CDR2, NRCoV2-19

<400>  62

Leu Thr Ser Gly Gly Thr Gly 
1               5           


<210>  63
<211>  11
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  CDR2, NRCoV2-20

<400>  63

Val Ala Val Ile Ser Gly Ser Asp Thr Glu Thr 
1               5                   10      


<210>  64
<211>  7
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  CDR2, NRCoV2-21

<400>  64

Ile Ser Ser Gly Gly Ser Thr 
1               5           


<210>  65
<211>  8
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  CDR2, NRCoV2-SR01

<400>  65

Ile Ser Gly Asn Gly Gly Val Thr 
1               5               


<210>  66
<211>  8
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  CDR2, NRCoV2-SR02

<400>  66

Ile Arg Tyr Ser Gly Gly Gly Ile 
1               5               


<210>  67
<211>  7
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  CDR2, NRCoV2-SR03

<400>  67

Ile Ser Ser Gly Gly Lys Thr 
1               5           


<210>  68
<211>  10
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  CDR2, NRCoV2-SR04

<400>  68

Ile Ser Met Gly Gly Asn Thr Asn Tyr Ala 
1               5                   10  


<210>  69
<211>  7
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  CDR2, NRCoV2-SR13

<400>  69

Ile Ser Ser Gly Gly Ser Thr 
1               5           


<210>  70
<211>  7
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  CDR2, NRCoV2-SR16

<400>  70

Ile Ser Thr Ser Gly Ala Val 
1               5           


<210>  71
<211>  15
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  CDR2, NRCoV2-S2A3

<400>  71

Lys Gln Arg Glu Leu Val Ala Ala Ile Ser Ser Gly Gly Thr Thr 
1               5                   10                  15  


<210>  72
<211>  7
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  CDR2, NRCoV2-S2A4

<400>  72

Ile Ser Thr Gly Gly Ser Arg 
1               5           


<210>  73
<211>  7
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  CDR2, NRCoV2-S2B3

<400>  73

Ile Ser Thr Gly Ser Asn Thr 
1               5           


<210>  74
<211>  10
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  CDR2, NRCoV2-S2H4

<400>  74

Ile Asn Ser Gly Asp Arg Asp Ser Thr Thr 
1               5                   10  


<210>  75
<211>  7
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  CDR2, NRCoV2-S2F3

<400>  75

Ile Thr Ser Gly Gly Ser Thr 
1               5           


<210>  76
<211>  7
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  CDR2, NRCoV2-S2G3

<400>  76

Ile Thr Ser Gly Gly Ala Thr 
1               5           


<210>  77
<211>  7
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  CDR2, NRCoV2-S2G4

<400>  77

Ile Ser Ser Asp Gly Asp Lys 
1               5           


<210>  78
<211>  7
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  CDR2, NRCoV2-S202

<400>  78

Ile Ser Ala Gly Gly Ser Thr 
1               5           


<210>  79
<211>  7
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  CDR2, NRCoV2-MRed02

<400>  79

Ile Trp Ser Asp Ser Arg Thr 
1               5           


<210>  80
<211>  7
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  CDR2, NRCoV2-MRed04

<400>  80

Ile Trp Ser Asp Thr Thr Thr 
1               5           


<210>  81
<211>  8
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  CDR2, NRCoV2-MRed03 and NRCoV2-MRed05

<400>  81

Ile Ser Ser Ser Asp Gly Ser Thr 
1               5               


<210>  82
<211>  8
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  CDR2, NRCoV2-MRed06

<400>  82

Ile Ser Ser Ser Asp Gly Ser Ala 
1               5               


<210>  83
<211>  7
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  CDR2, NRCoV2-MRed07

<400>  83

Ile Thr Arg Gly Gly Val Thr 
1               5           


<210>  84
<211>  8
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  CDR2, NRCoV2-MRed11

<400>  84

Ile Asn Ser Gly Gly Gly Ser Thr 
1               5               


<210>  85
<211>  7
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  CDR2, NRCoV2-MRed18

<400>  85

Val Ser Asp Gly Gly Thr Pro 
1               5           


<210>  86
<211>  7
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  CDR2, NRCoV2-MRed19

<400>  86

Met Thr Thr Ser Gly Ser Ala 
1               5           


<210>  87
<211>  8
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  CDR2, NRCoV2-MRed20

<400>  87

Ile Arg Glu Ser Gly Ser Gly Thr 
1               5               


<210>  88
<211>  7
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  CDR2, NRCoV2-MRed22

<400>  88

Ile Ser Ser Arg Gly Ser Thr 
1               5           


<210>  89
<211>  8
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  CDR2, NRCoV2-MRed25

<400>  89

Ile Ser Trp Arg Gly Asp Ser Thr 
1               5               


<210>  90
<211>  20
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  CDR3, NRCoV2-1a

<400>  90

Ala Ala Asp Tyr Ser Met Arg Pro Leu Trp Val Ser Arg Trp His Arg 
1               5                   10                  15      


Asp Tyr Glu Tyr 
            20  


<210>  91
<211>  20
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  CDR3, NRCoV2-1c

<400>  91

Ala Ala Asp Tyr Ser Met Arg Arg Phe Ala Val Gly Arg Trp His Arg 
1               5                   10                  15      


Asp Tyr Glu Tyr 
            20  


<210>  92
<211>  20
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  CDR3, NRCoV2-1d

<400>  92

Ala Ala Asp Tyr Ser Met Arg Pro Phe Ala Val Gly Arg Trp His Arg 
1               5                   10                  15      


Asp Tyr Glu Tyr 
            20  


<210>  93
<211>  15
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  CDR3, NRCoV2-02

<400>  93

Thr Lys Gly Pro Asp Leu Tyr Tyr Phe Gly Ser Gly Tyr Ser Asp 
1               5                   10                  15  


<210>  94
<211>  14
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  CDR3, NRCoV2-03

<400>  94

Asn Ile Tyr Gly Pro Thr Tyr Ser Thr Arg Arg Asn Glu Tyr 
1               5                   10                  


<210>  95
<211>  7
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  CDR3, NRCoV2-04

<400>  95

Trp Ser Ser Tyr Glu Ser Thr 
1               5           


<210>  96
<211>  15
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  CDR3, NRCoV2-05

<400>  96

Ser Lys Gly Pro Val Ser Ser Tyr Tyr Gly Ser Gly Tyr Asp Tyr 
1               5                   10                  15  


<210>  97
<211>  10
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  CDR3, NRCoV2-06

<400>  97

Asn Ala Arg His Tyr Gly Gly Ser Glu Tyr 
1               5                   10  


<210>  98
<211>  21
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  CDR3, NRCoV2-07

<400>  98

Ala Ala Val Gln Asp Val His Gly Asp Asn Tyr Tyr Cys Thr Ser Pro 
1               5                   10                  15      


Asn Glu Tyr Asn Val 
            20      


<210>  99
<211>  19
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  CDR3, NRCoV2-08

<400>  99

Ala Ala Asp Tyr Gln Tyr Ser Thr Tyr Cys Leu Gly Tyr Asp Ala His 
1               5                   10                  15      


Tyr Glu Tyr 
            


<210>  100
<211>  9
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  CDR3, NRCoV2-10

<400>  100

Tyr Ala Ala Asp Asp Leu Gly Asp Tyr 
1               5                   


<210>  101
<211>  19
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  CDR3, NRCoV2-11

<400>  101

Ala Ala Arg Ser Arg Asp Phe Ser Ser Pro Phe Ser Ala Thr Asp Thr 
1               5                   10                  15      


Tyr Thr Ser 
            


<210>  102
<211>  19
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  CDR3, NRCoV2-11a

<400>  102

Ala Ala Arg Ser Arg Asp Phe Ser Ser Pro Ile Ser Ala Thr Asp Lys 
1               5                   10                  15      


Tyr Gly Ser 
            


<210>  103
<211>  18
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  CDR3, NRCoV2-12

<400>  103

Ala Ala Asp Arg Gly Leu Ser Tyr Tyr Tyr Thr Arg Thr Thr Glu Tyr 
1               5                   10                  15      


Asn Tyr 
        


<210>  104
<211>  11
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  CDR3, NRCoV2-14

<400>  104

His Ala Val Asn Ala Asp Ile Gly Gly Asp Tyr 
1               5                   10      


<210>  105
<211>  10
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  CDR3, NRCoV2-15

<400>  105

Tyr Ala Ala Tyr Gly Gly Gly Gly Asp Tyr 
1               5                   10  


<210>  106
<211>  10
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  CDR3, NRCoV2-17

<400>  106

Gln Ala Ala Asn Val Asn Gly Gly Asp Tyr 
1               5                   10  


<210>  107
<211>  8
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  CDR3, NRCoV2-18

<400>  107

Ser Leu His Thr Ser His Asp Tyr 
1               5               


<210>  108
<211>  23
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  CDR3, NRCoV2-19

<400>  108

Ala Ala Asp Arg Ala Arg Leu Arg Phe Gly Cys Ser Leu Asn Phe Arg 
1               5                   10                  15      


Arg Glu Val Ala Tyr Asp Tyr 
            20              


<210>  109
<211>  18
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  CDR3, NRCoV2-20

<400>  109

Ala Ala Asp Arg Gly Met Ser Tyr Tyr Tyr Thr Arg Ala Thr Glu Tyr 
1               5                   10                  15      


Tyr Tyr 
        


<210>  110
<211>  22
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  CDR3, NRCoV2-21

<400>  110

Ala Ala Asp His Arg Gly Arg Ser Leu Arg Phe Gly Cys Ser Ser Ser 
1               5                   10                  15      


Thr Thr Asp Tyr Leu Tyr 
            20          


<210>  111
<211>  23
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  CDR3, NRCoV2-SR01

<400>  111

Ala Ala Thr Gly Ile Arg Ser Thr Trp Ser Val Tyr Gly Cys Ser Arg 
1               5                   10                  15      


Leu Ala Gly Pro Tyr Asp Tyr 
            20              


<210>  112
<211>  18
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  CDR3, NRCoV2-SR02

<400>  112

Ala Ala Asp Arg Leu Tyr Ser Arg Ala Cys Pro Thr Ala Gly Gly Arg 
1               5                   10                  15      


Asn Tyr 
        


<210>  113
<211>  17
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  CDR3, NRCoV2-SR03

<400>  113

Asn Arg Gly Gly Trp Glu Tyr Arg Ser Ser Tyr Tyr Ile Met Gly Pro 
1               5                   10                  15      


His 
    


<210>  114
<211>  17
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  CDR3, NRCoV2-SR04

<400>  114

Asn Thr Ala Ala Leu Val Gly Asn Arg Leu Leu Pro Met Ala Thr Ile 
1               5                   10                  15      


Thr 
    


<210>  115
<211>  20
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  CDR3, NRCoV2-SR13

<400>  115

Asn Met Gly Gly Trp Asp Tyr Arg Ser Asn Thr Tyr Ile Pro Gly Ser 
1               5                   10                  15      


Arg Ser Asp Tyr 
            20  


<210>  116
<211>  17
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  CDR3, NRCoV2-SR16

<400>  116

Asn Thr Gly Gly Trp Asp Tyr Arg Ser Ser Thr Phe Ile Met Gly Leu 
1               5                   10                  15      


Asn 
    


<210>  117
<211>  18
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  CDR3, NRCoV2-S2A3

<400>  117

Asn Thr Gly Ser Leu Ser Tyr Gly Gly Ser Val Tyr Tyr Pro Ser Tyr 
1               5                   10                  15      


Asp Asn 
        


<210>  118
<211>  15
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  CDR3, NRCoV2-S2A4

<400>  118

His Ala Ala Ala Arg Asp Ser His Gly Ile Tyr Leu Leu Asp Thr 
1               5                   10                  15  


<210>  119
<211>  11
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  CDR3, NRCoV2-S2B3

<400>  119

Asn Tyr Arg Ser Ile Tyr Tyr Gly Gln Asn Phe 
1               5                   10      


<210>  120
<211>  20
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  CDR3, NRCoV2-S2H4

<400>  120

Ala Leu Val Phe Gly Tyr Thr Ser Arg Asp Tyr Cys Leu Thr Pro Lys 
1               5                   10                  15      


Arg Gly Asn Tyr 
            20  


<210>  121
<211>  10
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  CDR3, NRCoV2-S2F3

<400>  121

Asn Leu Arg Asp Ile Leu Ser Gln Pro Phe 
1               5                   10  


<210>  122
<211>  11
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  CDR3, NRCoV2-S2G3

<400>  122

Tyr Thr Thr Lys Arg Asp Asp Ala Ser Val Tyr 
1               5                   10      


<210>  123
<211>  9
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  CDR3, NRCoV2-S2G4

<400>  123

Asn Lys His Trp Trp Thr Gly Asp Trp 
1               5                   


<210>  124
<211>  10
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  CDR3, NRCoV2-S202

<400>  124

Asn Tyr Gly Pro Gly Tyr Arg Lys Ala Ala 
1               5                   10  


<210>  125
<211>  14
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  CDR3, NRCoV2-MRed02 and NRCoV2-MRed04

<400>  125

Ala Ala Asp Arg Gly Phe Val Val Arg Gly Gln Tyr Asp Tyr 
1               5                   10                  


<210>  126
<211>  20
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  CDR3, NRCoV2-MRed03

<400>  126

Ala Thr Asp Ala Phe Ala Thr Cys Asp Ser Trp Tyr Ala Gln Ile Ala 
1               5                   10                  15      


Gln Tyr Asp Phe 
            20  


<210>  127
<211>  23
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  CDR3, NRCoV2-MRed05

<400>  127

Ala Thr Gly Pro Gln Ala Tyr Tyr Ser Gly Ser Tyr Tyr Phe Gln Cys 
1               5                   10                  15      


Pro Gln Ala Gly Met Asp Tyr 
            20              


<210>  128
<211>  17
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  CDR3, NRCoV2-MRed06

<400>  128

Ala Thr Asp Ser Phe Ser Ser Cys Ser Asp Tyr Glu Ser Gly Met Asp 
1               5                   10                  15      


Phe 
    


<210>  129
<211>  10
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  CDR3, NRCoV2-MRed07

<400>  129

Tyr Ala Asn Tyr Gly Trp Ala Ile Pro Tyr 
1               5                   10  


<210>  130
<211>  15
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  CDR3, NRCoV2-MRed11

<400>  130

Ala Thr Thr Ile Ser Asp Gly Ser Ser Trp Ser Thr Lys Ser Tyr 
1               5                   10                  15  


<210>  131
<211>  11
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  CDR3, NRCoV2-MRed18

<400>  131

Asn Tyr Tyr Asn Tyr Tyr Tyr Gly Arg Asn Phe 
1               5                   10      


<210>  132
<211>  11
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  CDR3, NRCoV2-MRed19

<400>  132

Tyr Met His Ser Val Tyr Tyr Gly Ile Asp Tyr 
1               5                   10      


<210>  133
<211>  20
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  CDR3, NRCoV2-MRed20

<400>  133

Ala Ala Lys Pro Pro Phe Tyr Gly Ser Gly Thr Tyr Ser Thr Pro Arg 
1               5                   10                  15      


Ala Tyr Leu Tyr 
            20  


<210>  134
<211>  10
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  CDR3, NRCoV2-MRed22

<400>  134

Asn Ala Arg Glu Phe Thr Gly Phe Asp Tyr 
1               5                   10  


<210>  135
<211>  17
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  CDR3, NRCoV2-MRed25

<400>  135

Ala Ala Glu Met Trp Gly Thr Ala Thr Ile Val Ala Ser Arg Tyr Thr 
1               5                   10                  15      


Tyr 
    


<210>  136
<211>  127
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  VHH, NRCoV2-1a

<400>  136

Glu Val Lys Leu Val Gln Ser Gly Gly Gly Ser Val Gln Pro Gly Gly 
1               5                   10                  15      


Ser Leu Arg Leu Ser Cys Ala Ala Ser Gly Ser Thr Leu Asp Tyr Tyr 
            20                  25                  30          


Ala Ile Gly Trp Phe Arg Gln Ala Pro Gly Lys Glu Arg Glu Trp Val 
        35                  40                  45              


Ser Cys Val Ser Ser Ser Asp Gly Ser Thr Leu Tyr Ala Asp Ser Val 
    50                  55                  60                  


Lys Gly Arg Phe Thr Ile Ser Arg Asp Asn Ala Lys Asn Thr Val Tyr 
65                  70                  75                  80  


Leu Gln Met Asn Ser Leu Lys Pro Glu Asp Thr Ala Val Tyr Val Cys 
                85                  90                  95      


Ala Ala Asp Tyr Ser Met Arg Pro Leu Trp Val Ser Arg Trp His Arg 
            100                 105                 110         


Asp Tyr Glu Tyr Trp Gly Gln Gly Thr Gln Val Thr Val Ser Ser 
        115                 120                 125         


<210>  137
<211>  127
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  VHH, NRCoV2-1c

<400>  137

Glu Val Gln Leu Val Glu Ser Gly Gly Gly Ser Val Gln Pro Gly Gly 
1               5                   10                  15      


Ser Leu Arg Leu Ser Cys Ala Ala Ser Gly Ser Ile Leu Asp Tyr Tyr 
            20                  25                  30          


Ala Val Gly Trp Phe Arg Gln Ala Pro Gly Lys Glu Arg Glu Trp Val 
        35                  40                  45              


Ser Ser Val Ser Ser Ser Asp Gly Ser Thr Leu Tyr Ala Asp Ser Val 
    50                  55                  60                  


Lys Gly Arg Phe Thr Ile Ser Arg Asp Asp Ala Lys Asn Thr Ile Tyr 
65                  70                  75                  80  


Leu Gln Met Asp Asn Leu Glu Pro Glu Asp Thr Ala Val Tyr Val Cys 
                85                  90                  95      


Ala Ala Asp Tyr Ser Met Arg Arg Phe Ala Val Gly Arg Trp His Arg 
            100                 105                 110         


Asp Tyr Glu Tyr Trp Gly Gln Gly Thr Gln Val Thr Val Ser Ser 
        115                 120                 125         


<210>  138
<211>  127
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  VHH, NRCoV2-1d

<400>  138

Glu Val Gln Leu Val Glu Ser Gly Gly Gly Ser Val Gln Pro Gly Gly 
1               5                   10                  15      


Ser Leu Arg Leu Ser Cys Ala Ala Ser Gly Ser Thr Leu Asp Tyr Tyr 
            20                  25                  30          


Ala Ile Gly Trp Phe Arg Gln Ala Pro Gly Lys Glu Arg Glu Trp Val 
        35                  40                  45              


Ser Ser Val Ser Ser Ser Asp Gly Asn Thr Leu Tyr Ala Asp Ser Val 
    50                  55                  60                  


Lys Gly Arg Phe Thr Ile Ser Arg Asp Asn Ala Lys Asn Thr Val Tyr 
65                  70                  75                  80  


Leu Gln Met Asn Ser Leu Lys Ala Glu Asp Thr Ala Val Tyr Val Cys 
                85                  90                  95      


Ala Ala Asp Tyr Ser Met Arg Pro Phe Ala Val Gly Arg Trp His Arg 
            100                 105                 110         


Asp Tyr Glu Tyr Trp Gly Gln Gly Thr Gln Val Thr Val Ser Ser 
        115                 120                 125         


<210>  139
<211>  122
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  VHH, NRCoV2-02

<400>  139

Glu Val Gln Leu Val Glu Ser Gly Gly Gly Leu Val Gln Ala Gly Gly 
1               5                   10                  15      


Ser Leu Arg Leu Ser Cys Ala Ala Ser Gly Phe Thr Phe Ser Asn Tyr 
            20                  25                  30          


Ala Met Asn Trp Val Arg Gln Ala Pro Gly Lys Gly Leu Glu Trp Val 
        35                  40                  45              


Ser Gly Ile Ser Gly Arg Gly Asp Asp Thr Arg Tyr Ala Asp Ser Val 
    50                  55                  60                  


Lys Gly Arg Phe Thr Ile Ser Arg Asp Asn Ala Lys Asn Thr Leu Phe 
65                  70                  75                  80  


Leu Gln Met Arg Ser Leu Arg Pro Glu Asp Thr Gly Val Tyr Arg Cys 
                85                  90                  95      


Thr Lys Gly Pro Asp Leu Tyr Tyr Phe Gly Ser Gly Tyr Ser Asp Arg 
            100                 105                 110         


Gly Gln Gly Thr Gln Val Thr Val Ser Ser 
        115                 120         


<210>  140
<211>  120
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  VHH, NRCoV2-03

<400>  140

Glu Val Gln Leu Val Ser Ser Gly Gly Gly Leu Val Gln Ala Gly Gly 
1               5                   10                  15      


Ser Leu Arg Leu Ser Cys Thr Ala Ser Gly Ile Thr Phe Ser Tyr Tyr 
            20                  25                  30          


Ala Met Gly Trp Tyr Arg Gln Ala Pro Gly Gln Pro Arg Glu Leu Val 
        35                  40                  45              


Ala Ser Met Ser Asn Met Asp Ser Thr Ile Tyr Ala Asp Ser Val Lys 
    50                  55                  60                  


Gly Arg Phe Thr Ile Ser Arg Asp Asn Ala Lys Thr Thr Ile Tyr Leu 
65                  70                  75                  80  


Gln Met Asn Asn Leu Lys Pro Glu Asp Thr Ala Val Tyr Phe Cys Asn 
                85                  90                  95      


Ile Tyr Gly Pro Thr Tyr Ser Thr Arg Arg Asn Glu Tyr Trp Gly Gln 
            100                 105                 110         


Gly Thr Gln Val Thr Val Ser Ser 
        115                 120 


<210>  141
<211>  113
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  VHH, NRCoV2-04

<400>  141

Ala Val Gln Leu Val Asp Ser Gly Gly Gly Leu Val Gln Pro Gly Gly 
1               5                   10                  15      


Ser Leu Arg Leu Ser Cys Ala Ala Ser Gly Ser Pro Phe Ser Asn Val 
            20                  25                  30          


Val Met Ala Trp Tyr Arg Gln Ala Pro Gly Lys Gln Arg Glu Arg Val 
        35                  40                  45              


Ala Phe Ile Ser Gly Gly Gly Ile Ala Asp Tyr Ile Met Ser Val Lys 
    50                  55                  60                  


Gly Arg Phe Thr Ile Ser Arg Asp Asn Ala Lys Asn Thr Val Tyr Leu 
65                  70                  75                  80  


Gln Met Asn Ser Leu Lys Pro Glu Asp Thr Ala Val Tyr Tyr Cys Trp 
                85                  90                  95      


Ser Ser Tyr Glu Ser Thr Trp Gly Gln Gly Thr Gln Val Thr Val Ser 
            100                 105                 110         


Ser 
    


<210>  142
<211>  122
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  VHH, NRCoV2-05

<400>  142

Glu Val Lys Leu Val Gln Ser Gly Gly Gly Leu Val Gln Pro Gly Gly 
1               5                   10                  15      


Ser Leu Arg Leu Ser Cys Ala Ala Ser Gly Phe Ile Phe Ser Asn Tyr 
            20                  25                  30          


Ala Met Asn Trp Val Arg Gln Ala Pro Gly Lys Gly Leu Glu Trp Val 
        35                  40                  45              


Ser Gly Ile Asn Ser Gly Gly Gly Asp Thr Arg Tyr Ala Asp Ser Val 
    50                  55                  60                  


Lys Gly Arg Phe Thr Val Ser Arg Asp Asn Ala Lys Asn Thr Leu Tyr 
65                  70                  75                  80  


Leu Gln Met Asn Ser Leu Lys Pro Glu Asp Thr Gly Val Tyr Tyr Cys 
                85                  90                  95      


Ser Lys Gly Pro Val Ser Ser Tyr Tyr Gly Ser Gly Tyr Asp Tyr Arg 
            100                 105                 110         


Gly Gln Gly Thr Gln Val Thr Val Ser Ser 
        115                 120         


<210>  143
<211>  116
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  VHH, NRCoV2-06

<400>  143

Glu Val Gln Leu Val Gln Ser Gly Gly Gly Leu Val Gln Ala Gly Glu 
1               5                   10                  15      


Ser Leu Arg Leu Ser Cys Ala Ala Ser Val Ser Thr Phe Ser Ser Tyr 
            20                  25                  30          


Ala Met Gly Trp Tyr Arg Gln Ala Pro Gly Lys Gln Arg Glu Leu Val 
        35                  40                  45              


Ala Ser Ile Gly Phe Val Gly Ala Thr Tyr Tyr Ile Asp Ser Val Lys 
    50                  55                  60                  


Gly Arg Phe Thr Ile Ser Arg Asp Asn Ala Lys Lys Thr Ala Tyr Leu 
65                  70                  75                  80  


Gln Met Asn Asp Leu Lys Pro Asp Asp Thr Ala Val Tyr Tyr Cys Asn 
                85                  90                  95      


Ala Arg His Tyr Gly Gly Ser Glu Tyr Trp Gly Gln Gly Thr Gln Val 
            100                 105                 110         


Thr Val Ser Ser 
        115     


<210>  144
<211>  128
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  VHH, NRCoV2-07

<400>  144

Gln Val Gln Leu Val Gln Ser Gly Gly Gly Leu Val Gln Pro Gly Gly 
1               5                   10                  15      


Ser Leu Arg Leu Ser Cys Ala Ala Ser Gly Val Thr Leu Asp Tyr Tyr 
            20                  25                  30          


Ala Ile Gly Trp Phe Arg Gln Ala Pro Gly Lys Glu Arg Glu Ala Val 
        35                  40                  45              


Ser Cys Ile Ser Ser Asn Gly Arg Arg Asn His Tyr Val Ala Ser Val 
    50                  55                  60                  


Arg Gly Arg Phe Thr Ile Ser Arg Asp Asn Ala Lys Ser Thr Val Tyr 
65                  70                  75                  80  


Leu Gln Met Asn Ser Leu Lys Pro Glu Asp Thr Ala Val Tyr Tyr Cys 
                85                  90                  95      


Ala Ala Val Gln Asp Val His Gly Asp Asn Tyr Tyr Cys Thr Ser Pro 
            100                 105                 110         


Asn Glu Tyr Asn Val Trp Gly Gln Gly Thr Gln Val Thr Val Ser Ser 
        115                 120                 125             


<210>  145
<211>  126
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  VHH, NRCoV2-08

<400>  145

Glu Val Gln Leu Gln Gln Ser Gly Gly Gly Leu Val Gln Pro Gly Gly 
1               5                   10                  15      


Ser Leu Arg Leu Ser Cys Ala Ala Ser Gly Phe Thr Leu Asp Asp Tyr 
            20                  25                  30          


Ala Ile Gly Trp Phe Arg Gln Ser Pro Gly Lys Glu Arg Glu Trp Val 
        35                  40                  45              


Thr Cys Ile Ser Arg Ser Gly Thr Thr Thr Tyr Tyr Thr Ala Ser Val 
    50                  55                  60                  


Lys Gly Arg Phe Thr Phe Ser Arg Asp Asn Ala Lys Asn Thr Ala Tyr 
65                  70                  75                  80  


Leu Gln Met Asn Ser Leu Arg Pro Glu Asp Thr Ala Val Tyr Tyr Cys 
                85                  90                  95      


Ala Ala Asp Tyr Gln Tyr Ser Thr Tyr Cys Leu Gly Tyr Asp Ala His 
            100                 105                 110         


Tyr Glu Tyr Trp Gly Gln Gly Thr Gln Val Thr Val Ser Ser 
        115                 120                 125     


<210>  146
<211>  115
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  VHH, NRCoV2-10

<400>  146

Gln Leu Gln Leu Gln Glu Ser Gly Gly Gly Leu Val Gln Pro Gly Gly 
1               5                   10                  15      


Ser Leu Thr Leu Ser Cys Ala Ala Ser Gly Asn Thr Phe Ser Arg Ser 
            20                  25                  30          


Asn Met His Trp Tyr Arg Gln Ala Pro Gly Ala Gln Arg Glu Trp Val 
        35                  40                  45              


Ala Ala Ile Ser Ser Arg Gly Ile Ser Thr Tyr Ala Tyr Ser Ala Lys 
    50                  55                  60                  


Gly Arg Phe Thr Ile Ser Arg Asp Asn Ala Lys Asn Thr Val Ser Leu 
65                  70                  75                  80  


Gln Met Asn Ser Leu Lys Pro Glu Asp Thr Ala Val Tyr Tyr Cys Tyr 
                85                  90                  95      


Ala Ala Asp Asp Leu Gly Asp Tyr Trp Gly Gln Gly Thr Gln Val Thr 
            100                 105                 110         


Val Ser Ser 
        115 


<210>  147
<211>  126
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  VHH, NRCoV2-11

<400>  147

Glu Val Gln Leu Val Ser Ser Gly Gly Gly Leu Val Gln Pro Gly Gly 
1               5                   10                  15      


Ser Leu Arg Leu Ser Cys Ala Ala Ser Gly Ser Ser Leu Asp Ser Tyr 
            20                  25                  30          


Ser Val Ser Trp Phe Arg Gln Ala Pro Gly Lys Glu Arg Glu Trp Ile 
        35                  40                  45              


Ser Phe Ile Ser Arg Tyr Tyr Ser Ser Thr Tyr Tyr Thr Asp Ser Val 
    50                  55                  60                  


Lys Gly Arg Phe Thr Thr Ser Arg Asp Gly Asp Gln Lys Thr Val His 
65                  70                  75                  80  


Leu Gln Met Asn Ser Leu Lys Pro Glu Asp Thr Ala Val Tyr Tyr Cys 
                85                  90                  95      


Ala Ala Arg Ser Arg Asp Phe Ser Ser Pro Phe Ser Ala Thr Asp Thr 
            100                 105                 110         


Tyr Thr Ser Trp Gly Gln Gly Thr Gln Val Thr Val Ser Ser 
        115                 120                 125     


<210>  148
<211>  126
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  VHH, NRCoV2-11a

<400>  148

Glu Val Gln Leu Gln Gln Ser Gly Gly Gly Leu Val Gln Pro Gly Gly 
1               5                   10                  15      


Ser Leu Arg Leu Ser Cys Ala Ala Ser Gly Phe Thr Leu Asp Ser Tyr 
            20                  25                  30          


Asn Ile Ala Trp Phe Arg Gln Ala Pro Gly Lys Glu Arg Glu Trp Ile 
        35                  40                  45              


Ser Tyr Ile Ser Arg Tyr Tyr Glu Ser Thr Tyr Tyr Ser Asp Ser Val 
    50                  55                  60                  


Lys Gly Arg Phe Thr Thr Ser Arg Asp Gly Asp Lys Lys Thr Val Ser 
65                  70                  75                  80  


Leu Gln Met Asn Ser Leu Lys Ser Glu Asp Thr Ala Val Tyr Tyr Cys 
                85                  90                  95      


Ala Ala Arg Ser Arg Asp Phe Ser Ser Pro Ile Ser Ala Thr Asp Lys 
            100                 105                 110         


Tyr Gly Ser Trp Gly Gln Gly Thr Gln Val Thr Val Ser Ser 
        115                 120                 125     


<210>  149
<211>  128
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  VHH, NRCoV2-12

<400>  149

Glu Val Gln Leu Gln Gln Ser Gly Gly Gly Leu Val Gln Ala Gly Gly 
1               5                   10                  15      


Ser Leu Arg Leu Ser Cys Ala Ala Ser Gly Arg Thr Phe Arg Asn Tyr 
            20                  25                  30          


Val Met Gly Trp Phe Arg Gln Ala Pro Gln Ala Pro Gly Lys Asp His 
        35                  40                  45              


Glu Phe Val Ala Ala Ile Ser Trp Gly Gly Thr Glu Ile Tyr Tyr Ala 
    50                  55                  60                  


Asp Ser Val Lys Gly Arg Phe Thr Ile Ser Arg Asp Asn Ala Lys Asn 
65                  70                  75                  80  


Thr Val Tyr Leu Gln Met Asn Ser Leu Lys Pro Glu Asp Thr Ala Val 
                85                  90                  95      


Tyr Tyr Cys Ala Ala Asp Arg Gly Leu Ser Tyr Tyr Tyr Thr Arg Thr 
            100                 105                 110         


Thr Glu Tyr Asn Tyr Trp Gly Gln Gly Thr Gln Val Thr Val Ser Ser 
        115                 120                 125             


<210>  150
<211>  117
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  VHH, NRCoV2-14

<400>  150

Glu Val Gln Leu Val Ser Ser Gly Gly Gly Leu Val Gln Ala Gly Gly 
1               5                   10                  15      


Ser Leu Arg Leu Ser Cys Glu Ala Ser Gly Thr Thr Phe Ser His Tyr 
            20                  25                  30          


Ala Val Gly Trp Tyr Arg Gln Ala Pro Gly Lys Gln Arg Glu Trp Val 
        35                  40                  45              


Ala Ser Ile Ser Val Phe Gly Ser Thr Thr Tyr Gly Gly Ser Val Ala 
    50                  55                  60                  


Gly Arg Phe Thr Ile Ser Arg Asp Asn Asp Lys Asn Thr Val Asp Leu 
65                  70                  75                  80  


Gln Met Asn Ser Leu Lys Pro Glu Asp Thr Ala Val Tyr Tyr Cys His 
                85                  90                  95      


Ala Val Asn Ala Asp Ile Gly Gly Asp Tyr Trp Gly Gln Gly Thr Gln 
            100                 105                 110         


Val Thr Val Ser Ser 
        115         


<210>  151
<211>  116
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  VHH, NRCoV2-15

<400>  151

Glu Val Gln Leu Val Ser Ser Gly Gly Gly Leu Val Glu Ala Gly Gly 
1               5                   10                  15      


Ser Leu Arg Leu Ser Cys Ile Ala Ser Gly Ser Thr Ser Gly Arg Asn 
            20                  25                  30          


Thr Met Gly Trp Phe Arg Gln Ala Pro Gly Lys Gln Arg Glu Trp Val 
        35                  40                  45              


Ala Ile Val Ser Thr Ser Gly Ala Thr Asn Tyr Ala Gly Ser Val Lys 
    50                  55                  60                  


Gly Arg Phe Thr Leu Ser Arg Asp Asn Ala Lys Asn Ala Val Tyr Leu 
65                  70                  75                  80  


Gln Met Asn Asn Leu Lys Pro Glu Asp Thr Ala Val Tyr Tyr Cys Tyr 
                85                  90                  95      


Ala Ala Tyr Gly Gly Gly Gly Asp Tyr Trp Gly Gln Gly Thr Gln Val 
            100                 105                 110         


Thr Val Ser Ser 
        115     


<210>  152
<211>  116
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  VHH, NRCoV2-17

<400>  152

Glu Val Gln Leu Gln Gln Ser Gly Gly Gly Leu Val Gln Thr Gly Gly 
1               5                   10                  15      


Ser Leu Arg Leu Ser Cys Ala Ala Ala Gly Ser Pro Phe Ser Gln Leu 
            20                  25                  30          


Ala Met Ser Trp Tyr Arg Gln Ile Ser Gly Lys Glu Arg Ala Trp Val 
        35                  40                  45              


Ala Ser Ile Ser Pro Thr Gly Asn Arg Ser Tyr Ser Lys Ile Ala Lys 
    50                  55                  60                  


Gly Arg Phe Thr Ile Ser Arg Asp Asn Ala Lys Asn Thr Val Thr Leu 
65                  70                  75                  80  


Gln Met Thr Ser Leu Lys Pro Glu Asp Thr Ala Ala Tyr Ile Cys Gln 
                85                  90                  95      


Ala Ala Asn Val Asn Gly Gly Asp Tyr Trp Gly Gln Gly Thr Gln Val 
            100                 105                 110         


Thr Val Ser Ser 
        115     


<210>  153
<211>  114
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  VHH, NRCoV2-18

<400>  153

Glu Val Gln Leu Val Glu Ser Gly Gly Gly Leu Val Gln Ala Gly Gly 
1               5                   10                  15      


Ser Leu Arg Leu Ser Cys Val Ala Ser Gly Ile Thr Ile Ser Gly Tyr 
            20                  25                  30          


Asn Met Ala Trp Trp Arg Gln Thr Arg Gly Lys Gln Thr Glu Arg Val 
        35                  40                  45              


Ala Phe Ile Asn Ser Gly Gly Ser Thr Thr Tyr Ser Asp Ser Val Lys 
    50                  55                  60                  


Gly Arg Phe Thr Ile Ser Arg Asp Asn Gly Lys Asn Thr Ala Tyr Leu 
65                  70                  75                  80  


Gln Met Asn Ser Leu Asn Ala Glu Asp Thr Ala Asp Tyr Phe Cys Ser 
                85                  90                  95      


Leu His Thr Ser His Asp Tyr Trp Gly Gln Gly Thr Gln Val Thr Val 
            100                 105                 110         


Ser Ser 
        


<210>  154
<211>  129
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  VHH, NRCoV2-19

<400>  154

Glu Val Gln Leu Leu Glu Ser Gly Gly Gly Leu Val Leu Pro Gly Gly 
1               5                   10                  15      


Ser Leu Arg Leu Ser Cys Ala Val Ser Gly Leu Thr Leu Asn Ser Tyr 
            20                  25                  30          


Ala Ile Gly Trp Phe Arg Gln Ala Pro Gly Lys Glu Arg Glu Gly Leu 
        35                  40                  45              


Ser Cys Leu Thr Ser Gly Gly Thr Gly Val Tyr Ala Glu Ser Val Lys 
    50                  55                  60                  


Gly Arg Phe Thr Ile Ser Arg Asp Asn Ala Glu Asn Thr Val Tyr Leu 
65                  70                  75                  80  


Gln Met Asn Ser Leu Lys Pro Glu Asp Thr Ala Val Tyr Tyr Cys Ala 
                85                  90                  95      


Ala Asp Arg Ala Arg Leu Arg Phe Gly Cys Ser Leu Asn Phe Arg Arg 
            100                 105                 110         


Glu Val Ala Tyr Asp Tyr Trp Gly Gln Gly Thr Gln Val Thr Val Ser 
        115                 120                 125             


Ser 
    


<210>  155
<211>  128
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  VHH, NRCoV2-20

<400>  155

Glu Val Gln Leu Gln Gln Ser Gly Gly Gly Leu Val Gln Pro Gly Gly 
1               5                   10                  15      


Ser Leu Arg Leu Ser Cys Ala Ala Ser Gly Arg Thr Phe Ser Asn Tyr 
            20                  25                  30          


Val Val Gly Trp Phe Arg Gln Ala Pro Gln Ala Pro Gly Lys Asp His 
        35                  40                  45              


Glu Phe Val Ala Val Ile Ser Gly Ser Asp Thr Glu Thr Tyr Tyr Ala 
    50                  55                  60                  


Asp Ser Val Lys Gly Arg Phe Thr Ile Ser Arg Asp Asn Ala Lys Asn 
65                  70                  75                  80  


Thr Val Tyr Leu Gln Met Asn Ser Leu Lys Pro Glu Asp Thr Ala Val 
                85                  90                  95      


Tyr Tyr Cys Ala Ala Asp Arg Gly Met Ser Tyr Tyr Tyr Thr Arg Ala 
            100                 105                 110         


Thr Glu Tyr Tyr Tyr Trp Gly Gln Gly Thr Gln Val Thr Val Ser Ser 
        115                 120                 125             


<210>  156
<211>  128
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  VHH, NRCoV2-21

<400>  156

Glu Val Gln Leu Val Glu Ser Gly Gly Gly Leu Val Gln Pro Gly Gly 
1               5                   10                  15      


Ser Leu Arg Leu Ser Cys Ala Thr Ser Gly Phe Thr Leu Asp Tyr Tyr 
            20                  25                  30          


Ala Ile Gly Trp Phe Arg Gln Ala Pro Gly Lys Glu Arg Glu Trp Val 
        35                  40                  45              


Ser Cys Ile Ser Ser Gly Gly Ser Thr Phe Tyr Val Asp Ser Val Lys 
    50                  55                  60                  


Gly Arg Phe Thr Ile Ser Arg Asp Asn Ala Lys Asp Thr Val Tyr Leu 
65                  70                  75                  80  


Gln Met Ser Ser Leu Lys Pro Asp Asp Thr Ala Val Tyr Tyr Cys Ala 
                85                  90                  95      


Ala Asp His Arg Gly Arg Ser Leu Arg Phe Gly Cys Ser Ser Ser Thr 
            100                 105                 110         


Thr Asp Tyr Leu Tyr Trp Gly Gln Gly Thr Gln Val Thr Val Ser Ser 
        115                 120                 125             


<210>  157
<211>  130
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  VHH, NRCoV2-SR01

<400>  157

Glu Val Gln Leu Val Gln Ser Gly Gly Gly Ser Val Gln Ala Gly Gly 
1               5                   10                  15      


Ser Leu Arg Leu Ser Cys Val Ala Ser Gly Phe Thr Phe Asp Asn Tyr 
            20                  25                  30          


Ala Ile Gly Trp Phe Arg Gln Ala Pro Gly Lys Glu Arg Glu Gly Val 
        35                  40                  45              


Ser Cys Ile Ser Gly Asn Gly Gly Val Thr Ile Tyr Ala Asp Ser Val 
    50                  55                  60                  


Lys Gly Arg Phe Thr Ile Ser Arg Asp Asn Ala Lys Asn Leu Val Tyr 
65                  70                  75                  80  


Leu Gln Met Asn Ser Leu Lys Pro Glu Asp Thr Ala Val Tyr Tyr Cys 
                85                  90                  95      


Ala Ala Thr Gly Ile Arg Ser Thr Trp Ser Val Tyr Gly Cys Ser Arg 
            100                 105                 110         


Leu Ala Gly Pro Tyr Asp Tyr Trp Gly Gln Gly Thr Gln Val Thr Val 
        115                 120                 125             


Ser Ser 
    130 


<210>  158
<211>  125
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  VHH, NRCoV2-SR02

<400>  158

Glu Val Gln Leu Val Asp Ser Gly Gly Gly Leu Val Gln Ala Gly Gly 
1               5                   10                  15      


Ser Leu Arg Leu Ser Cys Thr Ala Ser Glu Phe Thr Leu Asn Tyr Tyr 
            20                  25                  30          


Ser Ile Gly Trp Phe Arg Gln Ser Pro Gly Lys Glu Arg Glu Gly Val 
        35                  40                  45              


Ser Cys Ile Arg Tyr Ser Gly Gly Gly Ile Asp Tyr Ala Asp Ser Val 
    50                  55                  60                  


Lys Gly Arg Phe Thr Ile Ser Arg Asp Asn Ala Lys Asn Thr Val Tyr 
65                  70                  75                  80  


Leu Thr Met Asn Ser Leu Lys Pro Glu Asp Thr Ala Val Tyr Tyr Cys 
                85                  90                  95      


Ala Ala Asp Arg Leu Tyr Ser Arg Ala Cys Pro Thr Ala Gly Gly Arg 
            100                 105                 110         


Asn Tyr Trp Gly Gln Gly Thr Gln Val Thr Val Ser Ser 
        115                 120                 125 


<210>  159
<211>  123
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  VHH, NRCoV2-SR03

<400>  159

Ala Val Gln Leu Val Asp Ser Gly Gly Gly Leu Val Gln Ala Gly Gly 
1               5                   10                  15      


Ser Leu Arg Leu Ser Cys Ala Ala Ser Gly Ser Ile Phe Ser Asn Asn 
            20                  25                  30          


His Met Gly Trp Tyr Arg Gln Ala Pro Gly Lys Gln Arg Glu Leu Val 
        35                  40                  45              


Ala Ala Ile Ser Ser Gly Gly Lys Thr Asn Tyr Ala Asp Phe Ala Lys 
    50                  55                  60                  


Gly Arg Phe Thr Ile Ser Arg Asp Asn Ala Lys Asn Met Val Tyr Leu 
65                  70                  75                  80  


Gln Met Asn Ser Leu Lys Pro Glu Asp Thr Ala Val Tyr Tyr Cys Asn 
                85                  90                  95      


Arg Gly Gly Trp Glu Tyr Arg Ser Ser Tyr Tyr Ile Met Gly Pro His 
            100                 105                 110         


Trp Gly Gln Gly Thr Gln Val Thr Val Ser Ser 
        115                 120             


<210>  160
<211>  126
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  VHH, NRCoV2-SR04

<400>  160

Gln Val Gln Leu Val Glu Ser Gly Gly Gly Leu Val Gln Ala Gly Gly 
1               5                   10                  15      


Ser Leu Arg Leu Ser Cys Ala Ala Ser Gly Arg Thr Phe Ser Ser His 
            20                  25                  30          


Thr Val Gly Trp Tyr Arg Gln Ala Pro Gly Lys Gln Arg Asp Leu Val 
        35                  40                  45              


Ala Ala Ile Ser Met Gly Gly Asn Thr Asn Tyr Ala Asp Tyr Ala Asp 
    50                  55                  60                  


Ser Val Lys Gly Arg Phe Thr Ile Ser Arg Asp Asn Ala Lys Asn Thr 
65                  70                  75                  80  


Leu Tyr Leu Gln Met Asn Ser Leu Lys Pro Glu Asp Thr Ala Val Tyr 
                85                  90                  95      


Tyr Cys Asn Thr Ala Ala Leu Val Gly Asn Arg Leu Leu Pro Met Ala 
            100                 105                 110         


Thr Ile Thr Trp Gly Gln Gly Thr Gln Val Thr Val Ser Ser 
        115                 120                 125     


<210>  161
<211>  126
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  VHH, NRCoV2-SR13

<400>  161

Glu Val Gln Leu Val Glu Ser Gly Gly Gly Leu Val Thr Thr Gly Gly 
1               5                   10                  15      


Ser Leu Arg Leu Ser Cys Ala Thr Ser Gly Ser Arg Phe Gly Ser Lys 
            20                  25                  30          


His Met Ala Trp Tyr Arg Gln Ala Pro Gly Lys Gln Arg Asp Leu Val 
        35                  40                  45              


Ala Ala Ile Ser Ser Gly Gly Ser Thr His Tyr Gly Ser Ser Val Lys 
    50                  55                  60                  


Gly Arg Phe Thr Ile Ser Arg Asp Asn Ala Lys Ser Thr Val Tyr Leu 
65                  70                  75                  80  


Gln Met Asn Ser Leu Asn Pro Glu Asp Thr Ala Val Phe Tyr Cys Asn 
                85                  90                  95      


Met Gly Gly Trp Asp Tyr Arg Ser Asn Thr Tyr Ile Pro Gly Ser Arg 
            100                 105                 110         


Ser Asp Tyr Trp Gly Gln Gly Thr Gln Val Thr Val Ser Ser 
        115                 120                 125     


<210>  162
<211>  123
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  VHH, NRCoV2-SR16

<400>  162

Gln Val Gln Leu Val Gln Ser Ala Gly Gly Leu Val Gln Ala Gly Gly 
1               5                   10                  15      


Ser Leu Arg Leu Ser Cys Val Val Ser Gly Thr Thr Phe Ser Arg Tyr 
            20                  25                  30          


His Met Gly Trp His Arg Gln Ala Pro Gly Lys Gln Arg Asp Phe Val 
        35                  40                  45              


Ala Gly Ile Ser Thr Ser Gly Ala Val Thr Tyr Ala Asp Ser Ala Lys 
    50                  55                  60                  


Gly Arg Phe Thr Ile Ser Arg Asp Asn Ala Lys Asn Thr Val Tyr Leu 
65                  70                  75                  80  


Glu Met Asn Ser Leu Lys Leu Glu Asp Thr Ala Leu Tyr Tyr Cys Asn 
                85                  90                  95      


Thr Gly Gly Trp Asp Tyr Arg Ser Ser Thr Phe Ile Met Gly Leu Asn 
            100                 105                 110         


Trp Gly Gln Gly Thr Gln Val Thr Val Ser Ser 
        115                 120             


<210>  163
<211>  132
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  VHH, NRCoV2-S2A3

<400>  163

Glu Val Gln Leu Gln Gln Ser Gly Gly Gly Leu Val Gln Ala Gly Gly 
1               5                   10                  15      


Ser Leu Arg Leu Ser Cys Ala Ala Ser Gly Arg Pro Tyr Ser Asn Tyr 
            20                  25                  30          


Ala Met Ala Trp Tyr Arg Gln Ala Pro Gly Lys Gln His Glu Leu Val 
        35                  40                  45              


Ala Gly Lys Gln Arg Glu Leu Val Ala Ala Ile Ser Ser Gly Gly Thr 
    50                  55                  60                  


Thr Lys Tyr Ala Asp Ser Val Lys Ala Arg Phe Thr Ile Ser Arg Asp 
65                  70                  75                  80  


Asn Ala Lys Asn Thr Val Tyr Leu Gln Met Asn Ile Leu Arg Pro Glu 
                85                  90                  95      


Asp Thr Ala Val Tyr Tyr Cys Asn Thr Gly Ser Leu Ser Tyr Gly Gly 
            100                 105                 110         


Ser Val Tyr Tyr Pro Ser Tyr Asp Asn Trp Gly Gln Gly Thr Gln Val 
        115                 120                 125             


Thr Val Ser Ser 
    130         


<210>  164
<211>  121
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  VHH, NRCoV2-S2A4

<400>  164

Gln Val Gln Leu Val Gln Ser Gly Gly Gly Leu Val Gln Ala Gly Gly 
1               5                   10                  15      


Ser Leu Arg Leu Ser Cys Ala Val Ser Gly Ser Pro Phe Arg Ser Asn 
            20                  25                  30          


Val Met Glu Trp Tyr Arg Gln Ala Pro Gly Lys Gln Arg Glu Leu Val 
        35                  40                  45              


Ala Ser Ile Ser Thr Gly Gly Ser Arg Thr Tyr Thr Asp Ser Val Lys 
    50                  55                  60                  


Gly Arg Phe Thr Ile Ser Arg Asp Asn Ala Lys Asn Glu Ala Phe Leu 
65                  70                  75                  80  


Gln Met Asn Ser Leu Lys Pro Glu Asp Thr Ala Val Tyr Tyr Cys His 
                85                  90                  95      


Ala Ala Ala Arg Asp Ser His Gly Ile Tyr Leu Leu Asp Thr Trp Gly 
            100                 105                 110         


Gln Gly Thr Gln Val Thr Val Ser Ser 
        115                 120     


<210>  165
<211>  117
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  VHH, NRCoV2-S2B3

<400>  165

Gln Val Gln Leu Val Asp Ser Gly Gly Gly Leu Val Gln Ala Gly Gly 
1               5                   10                  15      


Ser Leu Arg Leu Ser Cys Ala Ala Ser Ala Ser Thr Phe Gly Asp Ser 
            20                  25                  30          


Ala Met Gly Tyr Tyr Arg Gln Ala Pro Gly Lys Gln Arg Glu Leu Val 
        35                  40                  45              


Ala Thr Ile Ser Thr Gly Ser Asn Thr Asn Tyr Ala Asp Ser Val Lys 
    50                  55                  60                  


Gly Arg Phe Thr Ile Ser Arg Asp Asp Ala Lys Asn Thr Val Tyr Leu 
65                  70                  75                  80  


Gln Met Asn Ser Leu Lys Pro Glu Asp Thr Ala Val Tyr Tyr Cys Asn 
                85                  90                  95      


Tyr Arg Ser Ile Tyr Tyr Gly Gln Asn Phe Trp Gly Gln Gly Thr Gln 
            100                 105                 110         


Val Thr Val Ser Ser 
        115         


<210>  166
<211>  129
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  VHH, NRCoV2-S2H4

<400>  166

Gln Val Gln Leu Val Gln Ser Gly Gly Gly Leu Val Gln Ala Gly Gly 
1               5                   10                  15      


Ser Leu Arg Leu Ser Cys Ala Ala Ser Gly Phe Thr Phe Asn Leu Tyr 
            20                  25                  30          


Ser Ile Ala Trp Phe Arg Gln Ala Pro Gly Lys Glu Arg Glu Gly Val 
        35                  40                  45              


Ser Cys Ile Asn Ser Gly Asp Arg Asp Ser Thr Thr Tyr Tyr Ala Asp 
    50                  55                  60                  


Ser Val Lys Gly Arg Phe Thr Ile Ser Arg Asp Asn Ala Lys His Thr 
65                  70                  75                  80  


Ala Tyr Leu Gln Met Asp Ser Leu Lys Pro Glu Asp Thr Ala Val Tyr 
                85                  90                  95      


Tyr Cys Ala Leu Val Phe Gly Tyr Thr Ser Arg Asp Tyr Cys Leu Thr 
            100                 105                 110         


Pro Lys Arg Gly Asn Tyr Trp Gly Gln Gly Thr Gln Val Thr Val Ser 
        115                 120                 125             


Ser 
    


<210>  167
<211>  116
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  VHH, NRCoV2-S2F3

<400>  167

Glu Val Gln Leu Val Gln Ser Gly Gly Gly Leu Val Gln Ala Gly Gly 
1               5                   10                  15      


Ser Leu Arg Leu Ser Cys Ala Thr Ser Val Arg Ile Leu Ser Val Pro 
            20                  25                  30          


Ala Met Gly Trp Tyr Arg Gln Ala Pro Gly Lys Glu Arg Glu Met Val 
        35                  40                  45              


Ala Val Ile Thr Ser Gly Gly Ser Thr Asn Tyr Ala Asp Ser Val Lys 
    50                  55                  60                  


Gly Arg Phe Thr Ile Ser Arg Asp Asn Ala Lys Asn Thr Val Tyr Leu 
65                  70                  75                  80  


Gln Met Asn Ser Leu Lys Leu Glu Asp Thr Ala Val Tyr Gln Cys Asn 
                85                  90                  95      


Leu Arg Asp Ile Leu Ser Gln Pro Phe Trp Gly Gln Gly Thr Gln Val 
            100                 105                 110         


Thr Val Ser Ser 
        115     


<210>  168
<211>  117
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  VHH, NRCoV2-S2G3

<400>  168

Gln Val Gln Leu Val Gln Ser Gly Gly Gly Ser Val Gln Ala Gly Gly 
1               5                   10                  15      


Ser Leu Arg Leu Ser Cys Ala Ala Ser Gly Ser Thr Phe Gly Ile Phe 
            20                  25                  30          


Leu Met Gly Trp Arg Arg Gln Ala Pro Gly Lys Gln Arg Glu Leu Val 
        35                  40                  45              


Ala His Ile Thr Ser Gly Gly Ala Thr Asn Tyr Ala Asp Ser Val Lys 
    50                  55                  60                  


Gly Arg Phe Thr Ile Ser Arg Asp Asn Ala Lys Asn Thr Val Tyr Leu 
65                  70                  75                  80  


Gln Met Asn Ser Leu Glu Pro Glu Asp Thr Ala Val Tyr Tyr Cys Tyr 
                85                  90                  95      


Thr Thr Lys Arg Asp Asp Ala Ser Val Tyr Trp Gly Gln Gly Thr Gln 
            100                 105                 110         


Val Thr Val Ser Ser 
        115         


<210>  169
<211>  115
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  VHH, NRCoV2-S2G4

<400>  169

Gln Val Gln Leu Val Gln Ser Gly Gly Gly Leu Val Gln Ala Gly Gly 
1               5                   10                  15      


Ser Leu Thr Leu Ser Cys Ala Pro Ser Gly Ser Thr Phe Ser Gly Tyr 
            20                  25                  30          


Ala Thr Asn Trp Tyr Arg Gln Ala Pro Gly Lys Gln Arg Glu Leu Val 
        35                  40                  45              


Ala Thr Ile Ser Ser Asp Gly Asp Lys Asn Tyr Ala Asp Ser Val Lys 
    50                  55                  60                  


Gly Arg Phe Thr Ile Ser Arg Asp Asn Ala Lys Asn Thr Val Tyr Leu 
65                  70                  75                  80  


Gln Met Asn Ser Leu Lys Pro Glu Asp Thr Ala Val Tyr Tyr Cys Asn 
                85                  90                  95      


Lys His Trp Trp Thr Gly Asp Trp Trp Gly Gln Gly Thr Gln Val Thr 
            100                 105                 110         


Val Ser Ser 
        115 


<210>  170
<211>  116
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  VHH, NRCoV2-S202

<400>  170

Gln Val Gln Leu Val Gln Ser Gly Gly Gly Leu Val Gln Ala Gly Gly 
1               5                   10                  15      


Ser Leu Arg Leu Ser Cys Ala Ala Ser Gly Ile Thr Val Ser Arg Ile 
            20                  25                  30          


Gly Met Gly Trp Tyr Arg Gln Ala Pro Gly Lys Gln Arg Asp Met Val 
        35                  40                  45              


Ala Val Ile Ser Ala Gly Gly Ser Thr Asn Tyr Ala Asp Ser Val Lys 
    50                  55                  60                  


Gly Arg Phe Thr Ile Ser Arg Asp Asn Ala Lys Asn Thr Val Tyr Leu 
65                  70                  75                  80  


Gln Met Asp Ser Leu Lys Pro Glu Asp Thr Ala Val Tyr Tyr Cys Asn 
                85                  90                  95      


Tyr Gly Pro Gly Tyr Arg Lys Ala Ala Trp Gly Gln Gly Thr Gln Val 
            100                 105                 110         


Thr Val Ser Ser 
        115     


<210>  171
<211>  120
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  VHH, NRCoV2-MRed02

<400>  171

Glu Val Gln Leu Val Glu Ser Gly Gly Gly Leu Val Gln Pro Gly Gly 
1               5                   10                  15      


Ser Leu Arg Leu Ser Cys Ala Ala Ser Gly Asn Ile Phe Ser Ile Asn 
            20                  25                  30          


Ser Met Gly Trp Phe Arg Gln Ala Pro Gly Lys Glu Arg Asp Val Val 
        35                  40                  45              


Ala Thr Ile Trp Ser Asp Ser Arg Thr Ser Tyr Ala Asp Ser Val Lys 
    50                  55                  60                  


Gly Arg Phe Thr Ile Ser Thr Asp Asn Thr Arg Thr Lys Val Tyr Leu 
65                  70                  75                  80  


Gln Met Ser Ser Leu Asn Pro Glu Asp Thr Ala Val Tyr Tyr Cys Ala 
                85                  90                  95      


Ala Asp Arg Gly Phe Val Val Arg Gly Gln Tyr Asp Tyr Trp Gly Gln 
            100                 105                 110         


Gly Thr Gln Val Thr Val Ser Ser 
        115                 120 


<210>  172
<211>  127
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  VHH, NRCoV2-MRed03

<400>  172

Glu Val Gln Leu Val Glu Ser Gly Gly Gly Leu Val Gln Pro Gly Gly 
1               5                   10                  15      


Ser Leu Arg Leu Ser Cys Ala Ala Ile Gly Phe Thr Leu Asp Tyr Tyr 
            20                  25                  30          


Ala Ile Gly Trp Phe Arg Gln Ala Pro Gly Lys Glu Arg Glu Gly Val 
        35                  40                  45              


Ser Cys Ile Ser Ser Ser Asp Gly Ser Thr Tyr Tyr Ala Asp Ser Val 
    50                  55                  60                  


Lys Gly Arg Phe Thr Ile Ser Arg Asp Asn Ala Lys Asn Thr Val Tyr 
65                  70                  75                  80  


Leu Gln Met Asn Ser Leu Lys Pro Glu Asp Thr Ala Val Tyr Tyr Cys 
                85                  90                  95      


Ala Thr Asp Ala Phe Ala Thr Cys Asp Ser Trp Tyr Ala Gln Ile Ala 
            100                 105                 110         


Gln Tyr Asp Phe Arg Gly Gln Gly Thr Gln Val Thr Val Ser Ser 
        115                 120                 125         


<210>  173
<211>  120
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  VHH, NRCoV2-MRed04

<400>  173

Glu Val Gln Leu Val Glu Ser Gly Gly Gly Leu Val Gln Pro Gly Arg 
1               5                   10                  15      


Ser Leu Arg Leu Ser Cys Ala Ala Ser Gly Asn Ser Phe Ser Ile Ser 
            20                  25                  30          


Thr Met Gly Trp Phe Arg Gln Ala Pro Gly Lys Glu Arg Glu Leu Val 
        35                  40                  45              


Ala Ser Ile Trp Ser Asp Thr Thr Thr Ser Tyr Ala Asp Ser Val Lys 
    50                  55                  60                  


Gly Arg Phe Thr Ile Ser Thr Asp Asn Thr Arg Thr Lys Val Tyr Leu 
65                  70                  75                  80  


Gln Met Ser Ser Leu Asn Pro Glu Asp Thr Ala Val Tyr Tyr Cys Ala 
                85                  90                  95      


Ala Asp Arg Gly Phe Val Val Arg Gly Gln Tyr Asp Tyr Trp Gly Gln 
            100                 105                 110         


Gly Thr Gln Val Thr Val Ser Ser 
        115                 120 


<210>  174
<211>  130
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  VHH, NRCoV2-MRed05

<400>  174

Glu Val Gln Leu Val Glu Ser Gly Gly Gly Leu Val Gln Pro Gly Gly 
1               5                   10                  15      


Ser Leu Arg Leu Ser Cys Ala Ala Ser Gly Phe Thr Leu Asp Tyr Tyr 
            20                  25                  30          


Ala Ile Gly Trp Phe Arg Gln Ala Pro Gly Lys Glu Arg Glu Gly Val 
        35                  40                  45              


Ser Cys Ile Ser Ser Ser Asp Gly Ser Thr Leu Tyr Ala Asp Ser Val 
    50                  55                  60                  


Lys Gly Arg Phe Thr Ile Ser Arg Asp Asn Ala Lys Asn Thr Val Tyr 
65                  70                  75                  80  


Leu Gln Met Asn Ser Leu Lys Pro Glu Asp Thr Ala Val Tyr Tyr Cys 
                85                  90                  95      


Ala Thr Gly Pro Gln Ala Tyr Tyr Ser Gly Ser Tyr Tyr Phe Gln Cys 
            100                 105                 110         


Pro Gln Ala Gly Met Asp Tyr Trp Gly Lys Gly Thr Gln Val Thr Val 
        115                 120                 125             


Ser Ser 
    130 


<210>  175
<211>  124
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  VHH, NRCoV2-MRed06

<400>  175

Glu Val Gln Leu Val Glu Ser Gly Gly Gly Leu Val Gln Ala Gly Gly 
1               5                   10                  15      


Ser Leu Arg Leu Ser Cys Ala Ala Ser Gly Phe Thr Leu Ala Tyr Tyr 
            20                  25                  30          


Ala Ile Gly Trp Phe Arg Gln Ala Pro Gly Lys Glu Arg Glu Gly Val 
        35                  40                  45              


Ser Cys Ile Ser Ser Ser Asp Gly Ser Ala His Tyr Ala Asp Ser Val 
    50                  55                  60                  


Lys Gly Arg Phe Thr Ile Ser Arg Asp Asn Ala Lys Asn Thr Val Ser 
65                  70                  75                  80  


Leu Gln Met Asn Ser Leu Lys Pro Glu Asp Thr Ala Val Tyr Tyr Cys 
                85                  90                  95      


Ala Thr Asp Ser Phe Ser Ser Cys Ser Asp Tyr Glu Ser Gly Met Asp 
            100                 105                 110         


Phe Trp Gly Lys Gly Thr Gln Val Thr Val Ser Ser 
        115                 120                 


<210>  176
<211>  116
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  VHH, NRCoV2-MRed07

<400>  176

Glu Val Gln Leu Val Glu Ser Gly Gly Gly Leu Val Gln Pro Gly Gly 
1               5                   10                  15      


Ser Leu Thr Leu Ser Cys Ala Ala Ser Gly Ser Ile Gly Pro Phe Asn 
            20                  25                  30          


Thr Met Gly Trp Tyr Arg Gln Ala Pro Gly Asn Gln Arg Glu Pro Ala 
        35                  40                  45              


Ala Ile Ile Thr Arg Gly Gly Val Thr Asn Tyr Ala Asp Ser Val Lys 
    50                  55                  60                  


Gly Arg Phe Thr Ile Ser Arg Asp Asn Ala Lys Asn Ala Val Tyr Leu 
65                  70                  75                  80  


Gln Met Asp Ser Leu Lys Pro Asp Asp Thr Ala Val Tyr Tyr Cys Tyr 
                85                  90                  95      


Ala Asn Tyr Gly Trp Ala Ile Pro Tyr Trp Gly Asn Gly Thr Gln Val 
            100                 105                 110         


Thr Val Ser Ser 
        115     


<210>  177
<211>  122
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  VHH, NRCoV2-MRed11

<400>  177

Glu Val Gln Leu Val Glu Ser Gly Gly Gly Leu Val Gln Ala Gly Gly 
1               5                   10                  15      


Ser Leu Arg Leu Ser Cys Ala Ala Ser Gly Phe Thr Phe Ser Ser Tyr 
            20                  25                  30          


Ala Met Ser Trp His Arg Gln Ala Pro Gly Lys Gly Leu Glu Trp Val 
        35                  40                  45              


Ser Ala Ile Asn Ser Gly Gly Gly Ser Thr Ser Tyr Ala Asp Ser Val 
    50                  55                  60                  


Lys Gly Arg Phe Ala Ile Ser Arg Asp Asn Ala Lys Asn Thr Leu Tyr 
65                  70                  75                  80  


Leu Gln Met Asn Ser Leu Lys Pro Glu Asp Thr Ala Val Tyr Tyr Cys 
                85                  90                  95      


Ala Thr Thr Ile Ser Asp Gly Ser Ser Trp Ser Thr Lys Ser Tyr Arg 
            100                 105                 110         


Gly Gln Gly Thr Gln Val Thr Val Ser Ser 
        115                 120         


<210>  178
<211>  117
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  VHH, NRCoV2-MRed18

<400>  178

Glu Val Gln Leu Val Glu Ser Gly Gly Gly Leu Val Gln Pro Gly Gly 
1               5                   10                  15      


Ser Leu Arg Leu Ser Cys Ala Ala Ser Thr Thr Val Phe Gly Arg Asn 
            20                  25                  30          


Ala Met Gly Trp Tyr Arg Gln Ala Pro Gly Lys Glu Arg Glu Leu Val 
        35                  40                  45              


Ala Thr Val Ser Asp Gly Gly Thr Pro Asn Tyr Ala Asp Ser Val Lys 
    50                  55                  60                  


Gly Arg Phe Thr Ile Ser Arg Asp Asn Ala Lys Asn Thr Ile Tyr Leu 
65                  70                  75                  80  


Gln Met Asn Ser Leu Glu Pro Glu Asp Thr Ala Val Tyr Tyr Cys Asn 
                85                  90                  95      


Tyr Tyr Asn Tyr Tyr Tyr Gly Arg Asn Phe Trp Gly Gln Gly Thr Gln 
            100                 105                 110         


Val Thr Val Ser Ser 
        115         


<210>  179
<211>  116
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  VHH, NRCoV2-MRed19

<400>  179

Glu Val Gln Leu Val Glu Ser Gly Gly Gly Leu Val Gln Pro Gly Gly 
1               5                   10                  15      


Ser Leu Arg Leu Ser Cys Ala Ala Ser Thr Ile Ile Phe Lys Gly Gln 
            20                  25                  30          


Thr Met Gly Trp Phe Arg Gln Ala Pro Gly Asn Glu Arg Glu Leu Val 
        35                  40                  45              


Ala Thr Met Thr Thr Ser Gly Ser Ala Asn Tyr Ala Asp Ser Val Lys 
    50                  55                  60                  


Gly Arg Phe Thr Ile Ser Arg Asp Asn Glu Lys Thr Val Thr Leu Gln 
65                  70                  75                  80  


Met Asn Ser Leu Lys Pro Glu Asp Thr Ala Leu Tyr Tyr Cys Tyr Met 
                85                  90                  95      


His Ser Val Tyr Tyr Gly Ile Asp Tyr Trp Gly Lys Gly Thr Gln Val 
            100                 105                 110         


Thr Val Ser Ser 
        115     


<210>  180
<211>  127
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  VHH, NRCoV2-MRed20

<400>  180

Glu Val Gln Leu Val Glu Ser Gly Gly Gly Ser Val Gln Ala Gly Gly 
1               5                   10                  15      


Ser Leu Arg Leu Ser Cys Ala Ala Ser Gly Leu Ser Phe Ser Ser Tyr 
            20                  25                  30          


Asp Met Gly Trp Phe Arg Gln Ala Pro Gly Lys Glu Arg Glu Phe Val 
        35                  40                  45              


Ala Ala Ile Arg Glu Ser Gly Ser Gly Thr Tyr Tyr Ala Asp Ser Val 
    50                  55                  60                  


Lys Gly Arg Phe Thr Ile Ser Arg Asp Asn Ala Lys Asn Thr Val Tyr 
65                  70                  75                  80  


Leu Gln Val Ser Ser Leu Lys Pro Glu Asp Thr Ala Val Tyr Thr Cys 
                85                  90                  95      


Ala Ala Lys Pro Pro Phe Tyr Gly Ser Gly Thr Tyr Ser Thr Pro Arg 
            100                 105                 110         


Ala Tyr Leu Tyr Trp Gly Gln Gly Thr Gln Val Thr Val Ser Ser 
        115                 120                 125         


<210>  181
<211>  116
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  VHH, NRCoV2-MRed22

<400>  181

Glu Val Gln Leu Val Glu Ser Gly Gly Gly Leu Val Gln Pro Gly Gly 
1               5                   10                  15      


Ser Leu Arg Leu Ser Cys Ala Ala Ser Gly Ser Val Phe Ala Ser Asn 
            20                  25                  30          


Ala Met Gly Trp Tyr Arg Gln Ala Pro Gly Lys Gln Arg Glu Leu Val 
        35                  40                  45              


Ala Thr Ile Ser Ser Arg Gly Ser Thr Asn Tyr Ala Asp Ser Val Lys 
    50                  55                  60                  


Gly Arg Phe Thr Ile Ser Arg Asp Asn Ala Lys Asn Thr Val Tyr Leu 
65                  70                  75                  80  


Gln Met Asn Ser Leu Gly Pro Glu Asp Thr Ala Val Tyr Tyr Cys Asn 
                85                  90                  95      


Ala Arg Glu Phe Thr Gly Phe Asp Tyr Trp Gly Gln Gly Thr Gln Val 
            100                 105                 110         


Thr Val Ser Ser 
        115     


<210>  182
<211>  124
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  VHH, NRCoV2-MRed25

<400>  182

Glu Val Gln Leu Val Glu Ser Gly Gly Gly Leu Val Gln Ala Gly Gly 
1               5                   10                  15      


Ser Leu Arg Leu Ser Cys Ala Ala Ser Gly His Thr Phe Ser Arg Tyr 
            20                  25                  30          


Gly Met Gly Trp Phe Arg Gln Ala Pro Gly Lys Glu Arg Glu Phe Val 
        35                  40                  45              


Ala Ala Ile Ser Trp Arg Gly Asp Ser Thr Tyr Tyr Arg Asp Ser Val 
    50                  55                  60                  


Asn Gly Arg Phe Thr Ile Ser Arg Asp Asn Ala Lys Asn Thr Val Tyr 
65                  70                  75                  80  


Leu Gly Met Asn Ser Leu Lys Pro Glu Asp Thr Ala Val Tyr Tyr Cys 
                85                  90                  95      


Ala Ala Glu Met Trp Gly Thr Ala Thr Ile Val Ala Ser Arg Tyr Thr 
            100                 105                 110         


Tyr Trp Gly Gln Gly Thr Gln Val Thr Val Ser Ser 
        115                 120                 


<210>  183
<211>  143
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  VHH consensus sequence


<220>
<221>  SITE
<222>  (1)..(1)
<223>  Xaa is Ala, Glu, or Gln

<220>
<221>  SITE
<222>  (2)..(2)
<223>  Xaa is Leu or Val

<220>
<221>  SITE
<222>  (3)..(3)
<223>  Xaa is Lys or Gln

<220>
<221>  SITE
<222>  (5)..(5)
<223>  Xaa is Leu, Gln, or Val

<220>
<221>  SITE
<222>  (6)..(6)
<223>  Xaa is Asp, Glu, Gln, or Ser

<220>
<221>  SITE
<222>  (8)..(8)
<223>  Xaa is Ala or Gly

<220>
<221>  SITE
<222>  (11)..(11)
<223>  Xaa is Leu or Ser

<220>
<221>  SITE
<222>  (13)..(13)
<223>  Xaa is Glu, Leu, Gln, or Thr

<220>
<221>  SITE
<222>  (14)..(14)
<223>  Xaa is Ala, Pro, or Thr

<220>
<221>  SITE
<222>  (16)..(16)
<223>  Xaa is Glu, Gly, or Arg

<220>
<221>  SITE
<222>  (19)..(19)
<223>  Xaa is Arg or Thr

<220>
<221>  SITE
<222>  (23)..(23)
<223>  Xaa is Ala, Glu, Ile, Thr, or Val

<220>
<221>  SITE
<222>  (24)..(24)
<223>  Xaa is Ala, Pro, Thr, or Val

<220>
<221>  SITE
<222>  (25)..(25)
<223>  Xaa is Ala, Ile, or Ser

<220>
<221>  SITE
<222>  (26)..(26)
<223>  Xaa is Ala, Glu, Gly, Thr, or Val

<220>
<221>  SITE
<222>  (27)..(27)
<223>  Xaa is Phe, His, Ile, Leu, Asn, Arg, Ser, Thr, or Val

<220>
<221>  SITE
<222>  (28)..(28)
<223>  Xaa is Ile, Pro, Arg, Ser, Thr, or Val

<220>
<221>  misc_feature
<222>  (29)..(29)
<223>  Xaa is Phe, Gly, Ile, Leu, Ser, Val, or Tyr

<220>
<221>  misc_feature
<222>  (30)..(30)
<223>  Xaa is Ala, Asp. Gly, Lys, Asn, Pro, Arg, or Ser

<220>
<221>  misc_feature
<222>  (31)..(31)
<223>  Xaa is Asp, Phe, Gly, His, Ile, Leu, Asn, Gln, Arg, Ser, Val, Tyr

<220>
<221>  misc_feature
<222>  (32)..(32)
<223>  Xaa is Phe, His, Ile, Lys, Leu, Asn, Pro, Gln, Ser, Val, or Tyr

<220>
<221>  misc_feature
<222>  (33)..(33)
<223>  Xaa is Ala, Asp, Gly, His, Leu, Asn, Ser, Thr, or Val

<220>
<221>  misc_feature
<222>  (34)..(34)
<223>  Xaa is Ile, Met, Thr, or Val

<220>
<221>  misc_feature
<222>  (35)..(35)
<223>  Xaa is Ala, Glu, Gly, His, Asn, or Ser

<220>
<221>  misc_feature
<222>  (36)..(36)
<223>  Xaa is Trp or Tyr

<220>
<221>  misc_feature
<222>  (37)..(37)
<223>  Xaa is Phe, His, Arg, Val, Trp, or Tyr

<220>
<221>  misc_feature
<222>  (40)..(40)
<223>  Xaa is Ala, Ile, Ser, or Thr

<220>
<221>  misc_feature
<222>  (41)..(41)
<223>  Xaa is Pro or absent

<220>
<221>  misc_feature
<222>  (42)..(42)
<223>  Xaa is Gln or absent

<220>
<221>  misc_feature
<222>  (43)..(43)
<223>  Xaa is Ala or absent

<220>
<221>  misc_feature
<222>  (44)..(44)
<223>  Xaa is Pro, Arg, or Ser

<220>
<221>  misc_feature
<222>  (46)..(46)
<223>  Xaa is Ala, Lys, Asn, or Gln

<220>
<221>  misc_feature
<222>  (47)..(47)
<223>  Xaa is Asp, Glu, Gly, Pro, or Gln

<220>
<221>  misc_feature
<222>  (48)..(48)
<223>  Xaa is His or absent

<220>
<221>  misc_feature
<222>  (49)..(49)
<223>  Xaa is Glu or absent

<220>
<221>  misc_feature
<222>  (50)..(50)
<223>  Xaa is Leu or absent

<220>
<221>  misc_feature
<222>  (50)..(50)
<223>  Xaa is Val or absent

<220>
<221>  misc_feature
<222>  (51)..(51)
<223>  Xaa can be any naturally occurring amino acid

<220>
<221>  misc_feature
<222>  (52)..(52)
<223>  Xaa is Ala or absent

<220>
<221>  misc_feature
<222>  (53)..(53)
<223>  Xaa is Gly or absent

<220>
<221>  misc_feature
<222>  (54)..(54)
<223>  Xaa is Lys or absent

<220>
<221>  misc_feature
<222>  (55)..(55)
<223>  Xaa is Gln or absent

<220>
<221>  misc_feature
<222>  (56)..(56)
<223>  Xaa is His, Leu, Arg, or Thr

<220>
<221>  misc_feature
<222>  (57)..(57)
<223>  Xaa is Ala, Asp, or Glu

<220>
<221>  misc_feature
<222>  (58)..(58)
<223>  Xaa is Ala, Phe, Gly, Leu, Met, Pro, Arg, Val, or Trp

<220>
<221>  misc_feature
<222>  (58)..(58)
<223>  Xaa is Lys, Asn, or Gln

<220>
<221>  misc_feature
<222>  (59)..(59)
<223>  Xaa is Ala, Ile, Leu, or Val

<220>
<221>  misc_feature
<222>  (60)..(60)
<223>  Xaa is Ala, Ser, or Thr

<220>
<221>  misc_feature
<222>  (61)..(61)
<223>  Xaa is Ala, Cys, Phe, Gly, His, Ile, Ser, Thr, Val, or Tyr

<220>
<221>  misc_feature
<222>  (62)..(62)
<223>  Xaa is Ile, Leu, Met, or Val

<220>
<221>  misc_feature
<222>  (63)..(63)
<223>  Xaa is Gly, Asn, Arg, Ser, Thr, or Trp

<220>
<221>  misc_feature
<222>  (64)..(64)
<223>  Xaa is Ala, Asp, Glu, Phe, Gly, Met, Asn, Pro, Arg, Ser, Thr, 
       Val, Trp, or Tyr

<220>
<221>  misc_feature
<222>  (65)..(65)
<223>  Xaa is Asp, Phe, Gly, Met, Asn, Arg, Ser, Thr, Val, Tyr, or 
       absent

<220>
<221>  misc_feature
<222>  (66)..(66)
<223>  Xaa is Asp, Gly, Ser, Thr, or Tyr

<220>
<221>  misc_feature
<222>  (67)..(67)
<223>  Xaa is Ala, Asp, Glu, Gly, Ile, Lys, Asn, Arg, Ser, Thr, or Val

<220>
<221>  misc_feature
<222>  (68)..(68)
<223>  Xaa is Ala, Asp, Glu, Gly, Lys, Asn, Pro, Arg, Ser, Thr, or Val

<220>
<221>  misc_feature
<222>  (69)..(69)
<223>  Xaa is Asn, Ser, or absent

<220>
<221>  misc_feature
<222>  (70)..(70)
<223>  Xaa is Thr, Tyr, or absent

<220>
<221>  misc_feature
<222>  (71)..(71)
<223>  Xaa is Ala, Gly, Ile, Asn, Thr, or absent

<220>
<221>  misc_feature
<222>  (72)..(72)
<223>  Xaa is Asp, Phe, His, Ile, Lys, Leu, Asn, Arg, Ser, Thr, Val, 
       Tyr, or absent

<220>
<221>  misc_feature
<222>  (73)..(73)
<223>  Xaa is Tyr or absent

<220>
<221>  misc_feature
<222>  (74)..(74)
<223>  Xaa is Ala, Gly, Ile, Arg, Ser, Thr, or Val

<220>
<221>  misc_feature
<222>  (75)..(75)
<223>  Xaa is Ala, Asp, Glu, Gly, Lys, Met, Ser, or Tyr

<220>
<221>  misc_feature
<222>  (76)..(76)
<223>  Xaa is Phe, Ile, or Ser

<220>
<221>  misc_feature
<222>  (77)..(77)
<223>  Xaa is Ala or Val

<220>
<221>  misc_feature
<222>  (78)..(78)
<223>  Xaa is Ala, Lys, Asn, or Val

<220>
<221>  misc_feature
<222>  (79)..(9)
<223>  Xaa is Ala or Gly

<220>
<221>  misc_feature
<222>  (79)..(79)
<223>  Xaa can be any naturally occurring amino acid

<220>
<221>  misc_feature
<222>  (82)..(82)
<223>  Xaa is Ala or Thr

<220>
<221>  misc_feature
<222>  (83)..(83)
<223>  Xaa is Phe, Ile, Leu, Thr, or Val

<220>
<221>  misc_feature
<222>  (85)..(85)
<223>  Xaa is Arg or Thr

<220>
<221>  misc_feature
<222>  (87)..(87)
<223>  Xaa is Asp, Gly, or Asn

<220>
<221>  misc_feature
<222>  (88)..(88)
<223>  Xaa is Ala, Asp, Glu, Gly, or Thr

<220>
<221>  misc_feature
<222>  (89)..(89)
<223>  Xaa is Glu, Lys, Gln, or Arg

<220>
<221>  misc_feature
<222>  (90)..(90)
<223>  Xaa is Asp, His, Lys, Asn, Ser, Thr, or absent

<220>
<221>  misc_feature
<222>  (91)..(91)
<223>  Xaa is Ala, Glu, Lys, Leu, Met, or Thr

<220>
<221>  misc_feature
<222>  (92)..(92)
<223>  Xaa is Ala, Ile, Leu, or Val

<220>
<221>  misc_feature
<222>  (93)..(93)
<223>  Xaa is Asp, Phe, His, Ser, Thr, or Tyr

<220>
<221>  misc_feature
<222>  (95)..(95)
<223>  Xaa is Glu, Gly, Gln, or Thr

<220>
<221>  misc_feature
<222>  (96)..(96)
<223>  Xaa is Met or Val

<220>
<221>  misc_feature
<222>  (97)..(97)
<223>  Xaa is Asp, Asn, Arg, Ser, or Thr

<220>
<221>  misc_feature
<222>  (98)..(98)
<223>  Xaa is Asp, Ile, Asn, or Ser

<220>
<221>  misc_feature
<222>  (100)..(100)
<223>  Xaa is Glu, Gly, Lys, Asn, or Arg

<220>
<221>  misc_feature
<222>  (101)..(101)
<223>  Xaa is Ala, Leu, Pro, or Ser

<220>
<221>  misc_feature
<222>  (102)..(102)
<223>  Xaa is Asp or Glu

<220>
<221>  misc_feature
<222>  (105)..(105)
<223>  Xaa is Ala or Gly

<220>
<221>  misc_feature
<222>  (106)..(106)
<223>  Xaa is Ala, Asp, Leu, or Val

<220>
<221>  misc_feature
<222>  (107)..(107)
<223>  Xaa is Phe or Tyr

<220>
<221>  misc_feature
<222>  (108)..(108)
<223>  Xaa is Phe, Ile, Gln, Arg, Thr, Val, or Tyr

<220>
<221>  misc_feature
<222>  (110)..(110)
<223>  Xaa is Ala, His, Asn, Gln, Ser, Thr, Trp, or Tyr

<220>
<221>  misc_feature
<222>  (111)..(111)
<223>  Xaa is Ala, Ile, Lys, Leu, Met, Arg, Ser, Thr, or Tyr

<220>
<221>  misc_feature
<222>  (112)..(112)
<223>  Xaa is Ala, Asp, Glu, Gly, His, Lys, Asn, Arg, Ser, Thr, Val, or 
       Tyr

<220>
<221>  misc_feature
<222>  (113)..(113)
<223>  Xaa is Ala, Asp, Glu, Phe, Gly, His, Ile, Lys, Asn, Pro, Gln, 
       Arg, Ser, Thr, Tyr, or absent

<220>
<221>  misc_feature
<222>  (114)..(114)
<223>  Xaa is Ala, Asp, Phe, Gly, Ile, Leu, Pro, Gln, Arg, Ser, Val, 
       Trp, or absent

<220>
<221>  misc_feature
<222>  (115)..(115)
<223>  Xaa is Ala, Asp, Glu, Phe, Gly, Leu, Met, Arg, Ser, Thr, Val, 
       Tyr, or absent

<220>
<221>  misc_feature
<222>  (116)..(116)
<223>  Xaa is Phe, Gly, His, Leu, Ser, Thr, Trp, Tyr, or absent

<220>
<221>  misc_feature
<222>  (117)..(117)
<223>  Xaa is Cys, Gly, His, Asn, Arg, Ser, Thr, Tyr, or absent

<220>
<221>  misc_feature
<222>  (118)..(118)
<223>  Xaa is Ala, Asp, Phe, Gly, Arg, Ser, Thr, Trp, or absent

<220>
<221>  misc_feature
<222>  (119)..(119)
<223>  Xaa is Ala, Cys, Asp, Gly, Ile, Leu, Asn, Pro, Arg, Ser, Tyr, or 
       absent

<220>
<221>  misc_feature
<222>  (120)..(120)
<223>  Xaa is Cys, Gly, Ile, Asn, Pro, Arg, Ser, Thr, Val, Trp, Tyr, or 
       absent

<220>
<221>  misc_feature
<222>  (121)..(121)
<223>  Xaa is Asp, Phe, Gly, Leu, Ser, Trp, Tyr, or absent

<220>
<221>  misc_feature
<222>  (122)..(122)
<223>  Xaa is Ala, Asp, Gly, Ile, Leu, Thr, Val, Trp, Tyr, or absent

<220>
<221>  misc_feature
<222>  (123)..(123)
<223>  Xaa is Cys, Phe, Asn, Val, or absent

<220>
<221>  misc_feature
<222>  (124)..(124)
<223>  Xaa is Phe, Gly, Ile, Leu, Gln, Ser, Tyr, or absent

<220>
<221>  misc_feature
<222>  (125)..(125)
<223>  Xaa is Ala, Cys, Asp, Gly, Pro, Arg, Ser, Thr, or absent

<220>
<221>  misc_feature
<222>  (126)..(126)
<223>  Xaa is Ala, Phe, Gly, Leu, Met, Pro, Gln, Arg, Ser, Thr, Val, 
       Trp, Tyr, or absent

<220>
<221>  misc_feature
<222>  (127)..(127)
<223>  Xaa is Ala, Asp, Glu, Gly, His, Ile, Pro, Gln, Arg, Ser, Thr, 
       Trp, or absent

<220>
<221>  misc_feature
<222>  (128)..(128)
<223>  Xaa is Ala, Asp, Gly, Ile, Lys, Met, Asn, Arg, Ser, Thr, Val, 
       Trp, Tyr, or absent

<220>
<221>  misc_feature
<222>  (129)..(129)
<223>  Xaa is Ala, Asp, Glu, Gly, His, Lys, Leu, Pro, Gln, Arg, Ser, 
       Thr, or absent

<220>
<221>  misc_feature
<222>  (130)..(130)
<223>  Xaa is Glu, Phe, Gly, His, Ile, Lys, Leu, Met, Asn, Gln, Arg, 
       Ser, Thr, or Tyr

<220>
<221>  misc_feature
<222>  (131)..(131)
<223>  Xaa is Ala, Asp, Glu, Gly, Ile, Leu, Asn, Pro, Ser, Thr, Val, or 
       Tyr

<220>
<221>  misc_feature
<222>  (132)..(132)
<223>  Xaa is Ala, Asp, Phe, His, Asn, Ser, Thr, Val, Trp, or Tyr

<220>
<221>  misc_feature
<222>  (133)..(133)
<223>  Xaa is Arg or Trp

<220>
<221>  misc_feature
<222>  (135)..(135)
<223>  Xaa can be any naturally occurring amino acid

<400>  183

Xaa Xaa Xaa Leu Xaa Xaa Ser Xaa Gly Gly Xaa Val Xaa Xaa Gly Xaa 
1               5                   10                  15      


Ser Leu Xaa Leu Ser Cys Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa 
            20                  25                  30          


Xaa Xaa Xaa Xaa Xaa Arg Gln Xaa Xaa Xaa Xaa Xaa Gly Xaa Xaa Xaa 
        35                  40                  45              


Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa 
    50                  55                  60                  


Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Arg 
65                  70                  75                  80  


Phe Xaa Xaa Ser Xaa Asp Xaa Xaa Xaa Xaa Xaa Xaa Xaa Leu Xaa Xaa 
                85                  90                  95      


Xaa Xaa Leu Xaa Xaa Xaa Asp Thr Xaa Xaa Xaa Xaa Cys Xaa Xaa Xaa 
            100                 105                 110         


Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa 
        115                 120                 125             


Xaa Xaa Xaa Xaa Xaa Gly Xaa Gly Thr Gln Val Thr Val Ser Ser 
    130                 135                 140             


<210>  184
<211>  133
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  VHH consensus sequence


<220>
<221>  misc_feature
<222>  (1)..(1)
<223>  Xaa is Ala, Glu, or Gln

<220>
<221>  misc_feature
<222>  (6)..(6)
<223>  Xaa is Asp, Glu, or Gln

<220>
<221>  misc_feature
<222>  (8)..(8)
<223>  Xaa is Ala or Gly

<220>
<221>  misc_feature
<222>  (11)..(11)
<223>  Xaa is Leu or Ser

<220>
<221>  misc_feature
<222>  (13)..(13)
<223>  Xaa is Gln or Thr

<220>
<221>  misc_feature
<222>  (14)..(14)
<223>  Xaa is Ala, Pro, or Thr

<220>
<221>  misc_feature
<222>  (19)..(19)
<223>  Xaa is Arg or Thr

<220>
<221>  misc_feature
<222>  (23)..(23)
<223>  Xaa is Ala, Thr, or Val

<220>
<221>  misc_feature
<222>  (24)..(24)
<223>  Xaa is Ala, Thr, or Val

<220>
<221>  misc_feature
<222>  (25)..(25)
<223>  Xaa is Ile or Ser

<220>
<221>  misc_feature
<222>  (26)..(26)
<223>  Xaa is Glu or Gly

<220>
<221>  misc_feature
<222>  (27)..(27)
<223>  Xaa is Phe, Arg, Ser, or Thr

<220>
<221>  misc_feature
<222>  (28)..(28)
<223>  Xaa is Ile, Arg, or Thr

<220>
<221>  misc_feature
<222>  (29)..(29)
<223>  Xaa is Phe, Gly, or Leu

<220>
<221>  misc_feature
<222>  (30)..(30)
<223>  Xaa is Asp, Ala, Gly, Asn, Pro, or Ser

<220>
<221>  misc_feature
<222>  (31)..(31)
<223>  Xaa is Phe, Asn, Arg, Ser, or Tyr

<220>
<221>  misc_feature
<222>  (32)..(32)
<223>  Xaa is His, Lys, Asn, or Tyr

<220>
<221>  misc_feature
<222>  (33)..(33)
<223>  Xaa is Ala, His, Ser, or Thr

<220>
<221>  misc_feature
<222>  (34)..(34)
<223>  Xaa is Ile, Met, or Val

<220>
<221>  misc_feature
<222>  (35)..(35)
<223>  Xaa is Ala or Gly

<220>
<221>  misc_feature
<222>  (37)..(37)
<223>  Xaa is Phe, His, or Tyr

<220>
<221>  misc_feature
<222>  (40)..(40)
<223>  Xaa is Ala or Ser

<220>
<221>  misc_feature
<222>  (43)..(43)
<223>  Xaa is Lys or Asn

<220>
<221>  misc_feature
<222>  (44)..(44)
<223>  Xaa is Glu or Gln

<220>
<221>  misc_feature
<222>  (46)..(46)
<223>  Xaa is Asp or Glu

<220>
<221>  misc_feature
<222>  (47)..(47)
<223>  Xaa is Phe, Gly, Leu, or Pro

<220>
<221>  misc_feature
<222>  (48)..(48)
<223>  Xaa is Ala or Val

<220>
<221>  misc_feature
<222>  (49)..(49)
<223>  Xaa is Ala or Ser

<220>
<221>  misc_feature
<222>  (50)..(50)
<223>  Xaa is Ala, Cys, Gly, or Ile

<220>
<221>  misc_feature
<222>  (52)..(52)
<223>  Xaa is Arg, Ser, or Thr

<220>
<221>  misc_feature
<222>  (53)..(53)
<223>  Xaa is Gly, Met, Arg, Ser, Thr, or Tyr

<220>
<221>  misc_feature
<222>  (54)..(54)
<223>  Xaa is Gly, Asn, or Ser

<220>
<221>  misc_feature
<222>  (55)..(55)
<223>  Xaa is Asp, Gly, or absent

<220>
<221>  misc_feature
<222>  (57)..(57)
<223>  Xaa is Ala, Gly, Lys, Asn, Ser, or Val

<220>
<221>  misc_feature
<222>  (58)..(58)
<223>  Xaa is Ala, Ile, Thr, or Val

<220>
<221>  misc_feature
<222>  (59)..(59)
<223>  Xaa is Asp, His, Ile, Asn, Thr, or Tyr

<220>
<221>  misc_feature
<222>  (61)..(61)
<223>  Xaa is Ala, Gly, or absent

<220>
<221>  misc_feature
<222>  (62)..(62)
<223>  Xaa is Asp or absent

<220>
<221>  misc_feature
<222>  (63)..(63)
<223>  Xaa is Tyr or absent

<220>
<221>  misc_feature
<222>  (64)..(64)
<223>  Xaa is Ala or absent

<220>
<221>  misc_feature
<222>  (65)..(65)
<223>  Xaa is Asp or Ser

<220>
<221>  misc_feature
<222>  (66)..(66)
<223>  Xaa is Phe or Ser

<220>
<221>  misc_feature
<222>  (67)..(67)
<223>  Xaa is Ala or Val

<220>
<221>  misc_feature
<222>  (80)..(80)
<223>  Xaa is Asn or Ser

<220>
<221>  misc_feature
<222>  (81)..(81)
<223>  Xaa is Ala, Leu, Met, or Thr

<220>
<221>  misc_feature
<222>  (82)..(82)
<223>  Xaa is Leu or Val

<220>
<221>  misc_feature
<222>  (83)..(83)
<223>  Xaa is Ser or Tyr

<220>
<221>  misc_feature
<222>  (85)..(85)
<223>  Xaa is Glu, Gln, or Thr

<220>
<221>  misc_feature
<222>  (87)..(87)
<223>  Xaa is Asp or Asn

<220>
<221>  misc_feature
<222>  (90)..(90)
<223>  Xaa is Lys or Asn

<220>
<221>  misc_feature
<222>  (91)..(91)
<223>  Xaa is Leu or Pro

<220>
<221>  misc_feature
<222>  (92)..(92)
<223>  Xaa is Asp or Glu

<220>
<221>  misc_feature
<222>  (96)..(96)
<223>  Xaa is Leu or Val

<220>
<221>  misc_feature
<222>  (97)..(97)
<223>  Xaa is Phe or Tyr

<220>
<221>  misc_feature
<222>  (100)..(100)
<223>  Xaa is Ala, Asn, or Tyr

<220>
<221>  misc_feature
<222>  (101)..(101)
<223>  Xaa is Ala, Met, Arg, or Thr

<220>
<221>  misc_feature
<222>  (102)..(102)
<223>  Xaa is Asp, Ala, Gly, Asn, or Thr

<220>
<221>  misc_feature
<222>  (103)..(103)
<223>  Xaa is Ala, Gly, Arg, Ser, or absent

<220>
<221>  misc_feature
<222>  (104)..(104)
<223>  Xaa is Phe, Ile, Leu, Trp, or absent

<220>
<221>  misc_feature
<222>  (105)..(105)
<223>  Xaa is Asp, Glu, Ala, Arg, Ser, Val, Tyr, or absent

<220>
<221>  misc_feature
<222>  (106)..(106)
<223>  Xaa is Gly, Ser, Thr, Tyr, or absent

<220>
<221>  misc_feature
<222>  (107)..(107)
<223>  Xaa is Cys, Asn, Arg, Thr, or absent

<220>
<221>  misc_feature
<222>  (108)..(108)
<223>  Xaa is Asp, Ser, Trp, or absent

<220>
<221>  misc_feature
<222>  (109)..(109)
<223>  Xaa is Asp, Asn, Ser, or absent

<220>
<221>  misc_feature
<222>  (110)..(110)
<223>  Xaa is Thr, Val, Trp, Tyr, or absent

<220>
<221>  misc_feature
<222>  (111)..(111)
<223>  Xaa is Glu, Phe, Arg, Tyr, or absent

<220>
<221>  misc_feature
<222>  (112)..(112)
<223>  Xaa is Gly or absent

<220>
<221>  misc_feature
<222>  (113)..(113)
<223>  Xaa is Ala, Cys, or absent

<220>
<221>  misc_feature
<222>  (114)..(114)
<223>  Xaa is Cys, Ser, or absent

<220>
<221>  misc_feature
<222>  (115)..(115)
<223>  Xaa is Ala, Ile, Leu, Pro, Arg, Ser, or absent

<220>
<221>  misc_feature
<222>  (116)..(116)
<223>  Xaa is Gln, Leu, Met, Pro, Thr, Tyr, or absent

<220>
<221>  misc_feature
<222>  (117)..(117)
<223>  Xaa is Ala, Gly, Ile, Pro, or absent

<220>
<221>  misc_feature
<222>  (118)..(118)
<223>  Xaa is Ala, Gly, Leu, Met, Pro, Ser, Trp, or absent

<220>
<221>  misc_feature
<222>  (119)..(119)
<223>  Xaa is Gln, Ala, Gly, Pro, Arg, or absent

<220>
<221>  misc_feature
<222>  (120)..(120)
<223>  Xaa is Ile, Met, Arg, Ser, Thr, Tyr, or absent

<220>
<221>  misc_feature
<222>  (121)..(121)
<223>  Xaa is Asp, Ile, Asn, Pro, or absent

<220>
<221>  misc_feature
<222>  (122)..(122)
<223>  Xaa is Phe, His, Asn, Thr, or Tyr

<220>
<221>  misc_feature
<222>  (123)..(123)
<223>  Xaa is Arg or Trp

<220>
<221>  misc_feature
<222>  (125)..(125)
<223>  Xaa is Gln, Lys, or Asn

<400>  184

Xaa Val Gln Leu Val Xaa Ser Xaa Gly Gly Xaa Val Xaa Xaa Gly Gly 
1               5                   10                  15      


Ser Leu Xaa Leu Ser Cys Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa 
            20                  25                  30          


Xaa Xaa Xaa Trp Xaa Arg Gln Xaa Pro Gly Xaa Xaa Arg Xaa Xaa Xaa 
        35                  40                  45              


Xaa Xaa Ile Xaa Xaa Xaa Xaa Gly Xaa Xaa Xaa Tyr Xaa Xaa Xaa Xaa 
    50                  55                  60                  


Xaa Xaa Xaa Lys Gly Arg Phe Thr Ile Ser Arg Asp Asn Ala Lys Xaa 
65                  70                  75                  80  


Xaa Xaa Xaa Leu Xaa Met Xaa Ser Leu Xaa Xaa Xaa Asp Thr Ala Xaa 
                85                  90                  95      


Xaa Tyr Cys Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa 
            100                 105                 110         


Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Gly Xaa Gly Thr Gln 
        115                 120                 125             


Val Thr Val Ser Ser 
    130             


<210>  185
<211>  137
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  VHH consensus sequence


<220>
<221>  misc_feature
<222>  (1)..(1)
<223>  Xaa is Ala or Pro

<220>
<221>  misc_feature
<222>  (5)..(5)
<223>  Xaa is Pro or Val

<220>
<221>  misc_feature
<222>  (6)..(6)
<223>  Xaa is Gln, Ala, or Pro

<220>
<221>  misc_feature
<222>  (11)..(11)
<223>  Xaa is Lys or Ser

<220>
<221>  misc_feature
<222>  (14)..(14)
<223>  Xaa is Asp or Asn

<220>
<221>  misc_feature
<222>  (19)..(19)
<223>  Xaa is Arg or Thr

<220>
<221>  misc_feature
<222>  (24)..(24)
<223>  Xaa is Asp, Asn, Thr, or Val

<220>
<221>  misc_feature
<222>  (26)..(26)
<223>  Xaa is Asp, Phe, Thr, or Val

<220>
<221>  misc_feature
<222>  (27)..(27)
<223>  Xaa is Cys, Gly, His, Lys, Arg, Ser, or Thr

<220>
<221>  misc_feature
<222>  (28)..(28)
<223>  Xaa is His, Asn, Ser, Thr, or Val

<220>
<221>  misc_feature
<222>  (29)..(29)
<223>  Xaa is Cys, Lys, Val, or Tyr

<220>
<221>  misc_feature
<222>  (30)..(30)
<223>  Xaa is Asp, Phe, Ile, Met, Arg, or Ser

<220>
<221>  misc_feature
<222>  (31)..(31)
<223>  Xaa is Gln, Phe, His, Lys, Met, Arg, Ser, or Val

<220>
<221>  misc_feature
<222>  (32)..(32)
<223>  Xaa is Cys, His, Met, Asn, Pro, Ser, or Tyr

<220>
<221>  misc_feature
<222>  (33)..(33)
<223>  Xaa is Asp, Gln, Phe, Lys, Ser, Thr, or Val

<220>
<221>  misc_feature
<222>  (34)..(34)
<223>  Xaa is His, Leu, or Thr

<220>
<221>  misc_feature
<222>  (35)..(35)
<223>  Xaa is Asp, Ala, Phe, Met, or Ser

<220>
<221>  misc_feature
<222>  (36)..(36)
<223>  Xaa is Trp or Tyr

<220>
<221>  misc_feature
<222>  (37)..(37)
<223>  Xaa is Cys, Gly, Arg, or Tyr

<220>
<221>  misc_feature
<222>  (43)..(43)
<223>  Xaa is Ile or Met

<220>
<221>  misc_feature
<222>  (44)..(44)
<223>  Xaa is Ala, Phe, or Pro

<220>
<221>  misc_feature
<222>  (45)..(45)
<223>  Xaa is Gly, Lys, or absent

<220>
<221>  misc_feature
<222>  (46)..(46)
<223>  Xaa is Ala or absent

<220>
<221>  misc_feature
<222>  (47)..(47)
<223>  Xaa is Lys or absent

<220>
<221>  misc_feature
<222>  (48)..(48)
<223>  Xaa is Val or absent

<220>
<221>  misc_feature
<222>  (49)..(49)
<223>  Xaa is Asp or absent

<220>
<221>  misc_feature
<222>  (50)..(50)
<223>  Xaa is Phe or absent

<220>
<221>  misc_feature
<222>  (51)..(51)
<223>  Xaa is Ile or absent

<220>
<221>  misc_feature
<222>  (52)..(52)
<223>  Xaa is Pro or absent

<220>
<221>  misc_feature
<222>  (53)..(53)
<223>  Xaa is Arg or absent

<220>
<221>  misc_feature
<222>  (54)..(54)
<223>  Xaa is Gln or Ala

<220>
<221>  misc_feature
<222>  (55)..(55)
<223>  Xaa is Cys, Phe, Lys, Leu, or Trp

<220>
<221>  misc_feature
<222>  (57)..(57)
<223>  Xaa is Asp or Ser

<220>
<221>  misc_feature
<222>  (58)..(58)
<223>  Xaa is Asp, Glu, Gly, Ser, Thr, or Val

<220>
<221>  misc_feature
<222>  (59)..(59)
<223>  Xaa is His, Leu, or Val

<220>
<221>  misc_feature
<222>  (60)..(60)
<223>  Xaa is Met, Arg, Ser, or absent

<220>
<221>  misc_feature
<222>  (61)..(61)
<223>  Xaa is Ala, Ser, Thr, or Trp

<220>
<221>  misc_feature
<222>  (62)..(62)
<223>  Xaa is Asp, Gln, Phe, Arg, Ser, or Thr

<220>
<221>  misc_feature
<222>  (63)..(63)
<223>  Xaa is Gln or absent

<220>
<221>  misc_feature
<222>  (64)..(64)
<223>  Xaa is Arg or absent

<220>
<221>  misc_feature
<222>  (65)..(65)
<223>  Xaa is Gln, Phe, Arg, or Ser

<220>
<221>  misc_feature
<222>  (66)..(66)
<223>  Xaa is Gln, Phe, or Ser

<220>
<221>  misc_feature
<222>  (67)..(67)
<223>  Xaa is Asp, Gln, Phe, Met, Ser, or Thr

<220>
<221>  misc_feature
<222>  (68)..(68)
<223>  Xaa is Asp, Ile, Asn, Arg, or Thr

<220>
<221>  misc_feature
<222>  (69)..(69)
<223>  Xaa is Ile, Met, Ser, Thr, or Tyr

<220>
<221>  misc_feature
<222>  (71)..(71)
<223>  Xaa is Asp, Arg, or Thr

<220>
<221>  misc_feature
<222>  (75)..(75)
<223>  Xaa is Ile or Met

<220>
<221>  misc_feature
<222>  (76)..(76)
<223>  Xaa is Asp or Phe

<220>
<221>  misc_feature
<222>  (79)..(79)
<223>  Xaa is Asp or Thr

<220>
<221>  misc_feature
<222>  (84)..(84)
<223>  Xaa is Gln or Met

<220>
<221>  misc_feature
<222>  (85)..(85)
<223>  Xaa is Asp or Ala

<220>
<221>  misc_feature
<222>  (87)..(87)
<223>  Xaa is Gly, Met, or absent

<220>
<221>  misc_feature
<222>  (88)..(88)
<223>  Xaa is Ala or Thr

<220>
<221>  misc_feature
<222>  (89)..(89)
<223>  Xaa is Asp, His, Lys, or Val

<220>
<221>  misc_feature
<222>  (90)..(90)
<223>  Xaa is Cys, Thr, or Tyr

<220>
<221>  misc_feature
<222>  (92)..(92)
<223>  Xaa is Phe or Pro

<220>
<221>  misc_feature
<222>  (93)..(93)
<223>  Xaa is Leu or Val

<220>
<221>  misc_feature
<222>  (94)..(94)
<223>  Xaa is Gln, Met, or Ser

<220>
<221>  misc_feature
<222>  (95)..(95)
<223>  Xaa is His or Ser

<220>
<221>  misc_feature
<222>  (97)..(97)
<223>  Xaa is Ala, Phe, Ile, or Arg

<220>
<221>  misc_feature
<222>  (98)..(98)
<223>  Xaa is Lys or Asn

<220>
<221>  misc_feature
<222>  (103)..(103)
<223>  Xaa is Lys or Val

<220>
<221>  misc_feature
<222>  (105)..(105)
<223>  Xaa is Pro, Thr, or Tyr

<220>
<221>  misc_feature
<222>  (107)..(107)
<223>  Xaa is Asp, Gly, Met, or Tyr

<220>
<221>  misc_feature
<222>  (108)..(108)
<223>  Xaa is Asp, ile, Lys, Leu, Thr, or Tyr

<220>
<221>  misc_feature
<222>  (109)..(109)
<223>  Xaa is Asp, Ala, Phe, Gly, Ile, Arg, Thr, Val, or Tyr

<220>
<221>  misc_feature
<222>  (110)..(110)
<223>  Xaa is Asp, Gln, Ala, Cys, His, Ile, Met, Asn, Ser, or absent

<220>
<221>  misc_feature
<222>  (111)..(111)
<223>  Xaa is Phe, His, Lys, Asn, Arg, Ser, Val, Tyr, or absent

<220>
<221>  misc_feature
<222>  (112)..(112)
<223>  Xaa is Gln, Cys, Leu, Ser, Tyr, or absent

<220>
<221>  misc_feature
<222>  (113)..(113)
<223>  Xaa is Phe, Ser, Thr, Trp, Tyr, or absent

<220>
<221>  misc_feature
<222>  (114)..(114)
<223>  Xaa is Phe, Gly, Ser, or absent

<220>
<221>  misc_feature
<222>  (115)..(115)
<223>  Xaa is Phe, Arg, Ser, Thr, or absent

<220>
<221>  misc_feature
<222>  (116)..(116)
<223>  Xaa is Asp, Gln, Phe, or absent

<220>
<221>  misc_feature
<222>  (117)..(117)
<223>  Xaa is Thr, Tyr, or absent

<220>
<221>  misc_feature
<222>  (118)..(118)
<223>  Xaa is Glu, His, Ser, Tyr, or absent

<220>
<221>  misc_feature
<222>  (119)..(119)
<223>  Xaa is Lys, Ser, Val, or absent

<220>
<221>  misc_feature
<222>  (120)..(120)
<223>  Xaa is Ser, Thr, Val, Tyr, or absent

<220>
<221>  misc_feature
<222>  (121)..(121)
<223>  Xaa is Asp, Gln, Cys, His, Asn, Trp, Tyr, or absent

<220>
<221>  misc_feature
<222>  (122)..(122)
<223>  Xaa is Gln, Ile, Lys, Asn, Arg, Ser, Thr, Trp, or Tyr

<220>
<221>  misc_feature
<222>  (123)..(123)
<223>  Xaa is Asp, Phe, Lys, Arg, Ser, or Thr

<220>
<221>  misc_feature
<222>  (124)..(124)
<223>  Xaa is Cys, Phe, His, Ile, Lys, Pro, Arg, Ser, or Tyr

<220>
<221>  misc_feature
<222>  (125)..(125)
<223>  Xaa is Asp, Gln, Lys, Met, Asn, Ser, Thr, or Val

<220>
<221>  misc_feature
<222>  (126)..(126)
<223>  Xaa is Asp, Cys, Met, Thr, Trp, or Tyr

<220>
<221>  misc_feature
<222>  (127)..(127)
<223>  Xaa is Arg or Trp

<220>
<221>  misc_feature
<222>  (129)..(129)
<223>  Xaa is Ile or Pro

<400>  185

Xaa Val Gln Leu Xaa Xaa Ser Gly Gly Gly Xaa Val Gln Xaa Gly Gly 
1               5                   10                  15      


Ser Leu Xaa Leu Ser Cys Ala Xaa Ser Xaa Xaa Xaa Xaa Xaa Xaa Xaa 
            20                  25                  30          


Xaa Xaa Xaa Xaa Xaa Arg Gln Ala Pro Gly Xaa Xaa Xaa Xaa Xaa Xaa 
        35                  40                  45              


Xaa Xaa Xaa Xaa Xaa Xaa Xaa Val Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa 
    50                  55                  60                  


Xaa Xaa Xaa Xaa Xaa Tyr Xaa Asp Ser Val Xaa Xaa Arg Phe Xaa Ile 
65                  70                  75                  80  


Ser Arg Asp Xaa Xaa Lys Xaa Xaa Xaa Xaa Leu Xaa Xaa Xaa Xaa Leu 
                85                  90                  95      


Xaa Xaa Glu Asp Thr Ala Xaa Tyr Xaa Cys Xaa Xaa Xaa Xaa Xaa Xaa 
            100                 105                 110         


Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Gly 
        115                 120                 125             


Xaa Gly Thr Gln Val Thr Val Ser Ser 
    130                 135         


<210>  186
<211>  133
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  VHH consensus sequence


<220>
<221>  misc_feature
<222>  (1)..(1)
<223>  Xaa is Asp, Ala, or Pro

<220>
<221>  misc_feature
<222>  (2)..(2)
<223>  Xaa is Lys or Val

<220>
<221>  misc_feature
<222>  (3)..(3)
<223>  Xaa is Ile or Pro

<220>
<221>  misc_feature
<222>  (5)..(5)
<223>  Xaa is Lys, Pro, or Val

<220>
<221>  misc_feature
<222>  (6)..(6)
<223>  Xaa is Gln, Ala, Pro, or Ser

<220>
<221>  misc_feature
<222>  (11)..(11)
<223>  Xaa is Lys or Ser

<220>
<221>  misc_feature
<222>  (13)..(13)
<223>  Xaa is Ala, Lys, or Pro

<220>
<221>  misc_feature
<222>  (14)..(14)
<223>  Xaa is Asp, Asn, or Thr

<220>
<221>  misc_feature
<222>  (16)..(16)
<223>  Xaa is Ala, Phe, or Arg

<220>
<221>  misc_feature
<222>  (19)..(19)
<223>  Xaa is Arg or Thr

<220>
<221>  misc_feature
<222>  (23)..(23)
<223>  Xaa is Asp, Ala, His, Thr, or Val

<220>
<221>  misc_feature
<222>  (24)..(24)
<223>  Xaa is Asp, Thr, or Val

<220>
<221>  misc_feature
<222>  (25)..(25)
<223>  Xaa is Asp or Ser

<220>
<221>  misc_feature
<222>  (26)..(26)
<223>  Xaa is Phe or Val

<220>
<221>  misc_feature
<222>  (27)..(27)
<223>  Xaa is Cys, His, Lys, Met, Arg, Ser, Thr, or Val

<220>
<221>  misc_feature
<222>  (28)..(28)
<223>  Xaa is His, Asn, Ser, or Thr

<220>
<221>  misc_feature
<222>  (29)..(29)
<223>  Xaa is Cys, His, Lys, or Ser

<220>
<221>  misc_feature
<222>  (30)..(30)
<223>  Xaa is Gln, Phe, Met, Arg, or Ser

<220>
<221>  misc_feature
<222>  (31)..(31)
<223>  Xaa is Gln, Phe, Gly, His, Met, Pro, Arg, Ser, or Tyr

<220>
<221>  misc_feature
<222>  (32)..(32)
<223>  Xaa is Lys, Met, Ser, Val, or Tyr

<220>
<221>  misc_feature
<222>  (33)..(33)
<223>  Xaa is Asp, Met, Ser, Thr, or Val

<220>
<221>  misc_feature
<222>  (34)..(34)
<223>  Xaa is His, Leu, or Val

<220>
<221>  misc_feature
<222>  (35)..(35)
<223>  Xaa is Asp, Phe, Gly, Met, or Ser

<220>
<221>  misc_feature
<222>  (37)..(37)
<223>  Xaa is Cys, Val, Trp, or Tyr

<220>
<221>  misc_feature
<222>  (40)..(40)
<223>  Xaa is Asp, His, Ser, or Thr

<220>
<221>  misc_feature
<222>  (41)..(41)
<223>  Xaa is Asn or absent

<220>
<221>  misc_feature
<222>  (42)..(42)
<223>  Xaa is Pro or absent

<220>
<221>  misc_feature
<222>  (43)..(43)
<223>  Xaa is Asp or absent

<220>
<221>  misc_feature
<222>  (44)..(44)
<223>  Xaa is Asn, Arg, or Ser

<220>
<221>  misc_feature
<222>  (46)..(46)
<223>  Xaa is Asp, Ile, or Pro

<220>
<221>  misc_feature
<222>  (47)..(47)
<223>  Xaa is Gln, Ala, Phe, Asn, or Pro

<220>
<221>  misc_feature
<222>  (48)..(48)
<223>  Xaa is Gly, Lys, Arg, or Thr

<220>
<221>  misc_feature
<222>  (49)..(49)
<223>  Xaa is Asp, Gln, or Ala

<220>
<221>  misc_feature
<222>  (50)..(50)
<223>  Xaa is Asp, Cys, Phe, Lys, Arg, Val, or Trp

<220>
<221>  misc_feature
<222>  (51)..(51)
<223>  Xaa is His, Lys, or Val

<220>
<221>  misc_feature
<222>  (52)..(52)
<223>  Xaa is Asp, Ser, or Thr

<220>
<221>  misc_feature
<222>  (53)..(53)
<223>  Xaa is Asp, Glu, Cys, Phe, His, Ser, Thr, Val, or Tyr

<220>
<221>  misc_feature
<222>  (54)..(54)
<223>  Xaa is His, Lys, Leu, or Val

<220>
<221>  misc_feature
<222>  (55)..(55)
<223>  Xaa is Phe, Met, Ser, Thr, or Trp

<220>
<221>  misc_feature
<222>  (56)..(56)
<223>  Xaa is Cys, Phe, Met, Asn, Arg, Ser, Thr, Val, Trp, or absent

<220>
<221>  misc_feature
<222>  (57)..(57)
<223>  Xaa is Phe, Met, Arg, Ser, Tyr, or absent

<220>
<221>  misc_feature
<222>  (58)..(58)
<223>  Xaa is Gln, Cys, Phe, Leu, Arg, Ser, Thr, Val, or Tyr

<220>
<221>  misc_feature
<222>  (59)..(59)
<223>  Xaa is Gln, Ala, Phe, Arg, Ser, or Thr

<220>
<221>  misc_feature
<222>  (60)..(60)
<223>  Xaa is Asp, Gln, Ala, His, Met, Arg, Ser, or Thr

<220>
<221>  misc_feature
<222>  (61)..(61)
<223>  Xaa is Asp, Phe, His, Met, Arg, Ser, or Thr

<220>
<221>  misc_feature
<222>  (62)..(62)
<223>  Xaa is Gln, Cys, Gly, His, Lys, Met, Arg, Ser, Thr, Val, or Tyr

<220>
<221>  misc_feature
<222>  (64)..(64)
<223>  Xaa is Asp, Phe, His, Ser, Thr, or Val

<220>
<221>  misc_feature
<222>  (65)..(65)
<223>  Xaa is Asp, Gln, Ala, Phe, Ile, Leu, or Tyr

<220>
<221>  misc_feature
<222>  (66)..(66)
<223>  Xaa is His or Ser

<220>
<221>  misc_feature
<222>  (67)..(67)
<223>  Xaa is Asp or Val

<220>
<221>  misc_feature
<222>  (68)..(68)
<223>  Xaa is Asp, Ile, or Arg

<220>
<221>  misc_feature
<222>  (73)..(73)
<223>  Xaa is Cys, His, Lys, Thr, or Val

<220>
<221>  misc_feature
<222>  (75)..(75)
<223>  Xaa is Arg or Thr

<220>
<221>  misc_feature
<222>  (77)..(77)
<223>  Xaa is Gln, Phe, or Met

<220>
<221>  misc_feature
<222>  (78)..(78)
<223>  Xaa is Asp, Gln, Phe, or Thr

<220>
<221>  misc_feature
<222>  (79)..(79)
<223>  Xaa is Ala, Ile, Pro, or Arg

<220>
<221>  misc_feature
<222>  (80)..(80)
<223>  Xaa is Gln, Ile, Met, Ser, or Thr

<220>
<221>  misc_feature
<222>  (81)..(81)
<223>  Xaa is Asp, Ile, or Thr

<220>
<221>  misc_feature
<222>  (82)..(82)
<223>  Xaa is Asp, His, Lys, or Val

<220>
<221>  misc_feature
<222>  (83)..(83)
<223>  Xaa is Gln, Cys, Gly, Ser, Thr, or Tyr

<220>
<221>  misc_feature
<222>  (87)..(87)
<223>  Xaa is Gln, Met, Arg, Ser, or Thr

<220>
<221>  misc_feature
<222>  (88)..(88)
<223>  Xaa is Gln, Met, or Ser

<220>
<221>  misc_feature
<222>  (90)..(90)
<223>  Xaa is Ala, Ile, Met, or Arg

<220>
<221>  misc_feature
<222>  (91)..(91)
<223>  Xaa is Asp, Asn, or Ser

<220>
<221>  misc_feature
<222>  (92)..(92)
<223>  Xaa is Gln or Ala

<220>
<221>  misc_feature
<222>  (95)..(95)
<223>  Xaa is Asp or Phe

<220>
<221>  misc_feature
<222>  (96)..(96)
<223>  Xaa is Asp, Gln, or Val

<220>
<221>  misc_feature
<222>  (98)..(98)
<223>  Xaa is Cys, His, Arg, Val, or Tyr

<220>
<221>  misc_feature
<222>  (100)..(100)
<223>  Xaa is Asp, Gly, Met, Pro, Ser, Thr, Trp, or Tyr

<220>
<221>  misc_feature
<222>  (101)..(101)
<223>  Xaa is Asp, His, Ile, Lys, Ser, or Thr

<220>
<221>  misc_feature
<222>  (102)..(102)
<223>  Xaa is Asp, Gln, Phe, Gly, Arg, Ser, Val, or Tyr

<220>
<221>  misc_feature
<222>  (103)..(103)
<223>  Xaa is Phe, Gly, Met, Asn, Pro, Arg, Ser, Tyr, or absent

<220>
<221>  misc_feature
<222>  (104)..(104)
<223>  Xaa is Asp, Gln, Phe, Asn, Pro, Arg, Val, or absent

<220>
<221>  misc_feature
<222>  (105)..(105)
<223>  Xaa is Asp, Gln, Cys, Phe, Lys, Leu, Arg, Ser, Thr, Val, Tyr, or 
       absent

<220>
<221>  misc_feature
<222>  (106)..(106)
<223>  Xaa is Cys, Gly, Lys, Met, Arg, Ser, Val, Tyr, or absent

<220>
<221>  misc_feature
<222>  (107)..(107)
<223>  Xaa is Asp, Ala, Arg, Ser, Val, Tyr, or absent

<220>
<221>  misc_feature
<222>  (108)..(108)
<223>  Xaa is Cys, Phe, Lys, Leu, Ser, Tyr, or absent

<220>
<221>  misc_feature
<222>  (109)..(109)
<223>  Xaa is Gln, Phe, Arg, or absent

<220>
<221>  misc_feature
<222>  (110)..(110)
<223>  Xaa is Glu, Met, Asn, Arg, Ser, or absent

<220>
<221>  misc_feature
<222>  (111)..(111)
<223>  Xaa is Cys, Lys, Ser, Thr, Tyr, or absent

<220>
<221>  misc_feature
<222>  (112)..(112)
<223>  Xaa is Asp, Phe, Lys, Trp, Tyr, or absent

<220>
<221>  misc_feature
<222>  (113)..(113)
<223>  Xaa is Glu, Cys, Met, Asn, Val, Tyr, or absent

<220>
<221>  misc_feature
<222>  (114)..(114)
<223>  Xaa is Cys, Phe, His, Lys, Pro, Ser, Tyr, or absent

<220>
<221>  misc_feature
<222>  (115)..(115)
<223>  Xaa is Glu, Phe, Arg, Ser, Thr, or absent

<220>
<221>  misc_feature
<222>  (116)..(116)
<223>  Xaa is Asp, Asn, Arg, Ser, Trp, Tyr, or absent

<220>
<221>  misc_feature
<222>  (117)..(117)
<223>  Xaa is Asp, Gln, Ala, Phe, Gly, Asn, Pro, Arg, Thr, Val, Tyr, or 
       absent

<220>
<221>  misc_feature
<222>  (118)..(118)
<223>  Xaa is Asp, Gln, Phe, His, Met, Arg, Ser, Thr, Val, or absent

<220>
<221>  misc_feature
<222>  (119)..(119)
<223>  Xaa is Asp, Gln, Ala, Phe, Gly, Ile, Lys, Pro, Arg, Ser, Thr, or 
       absent

<220>
<221>  misc_feature
<222>  (120)..(120)
<223>  Xaa is Phe, Gly, Leu, Met, Ser, Tyr, or absent

<220>
<221>  misc_feature
<222>  (121)..(121)
<223>  Xaa is Gln, Ala, Phe, Lys, Met, Ser, Thr, or Tyr

<220>
<221>  misc_feature
<222>  (122)..(122)
<223>  Xaa is Gln, Ser, Thr, Val, or Tyr

<220>
<221>  misc_feature
<222>  (123)..(123)
<223>  Xaa is Arg or Trp

<220>
<221>  misc_feature
<222>  (125)..(125)
<223>  Xaa is Ile or Pro

<400>  186

Xaa Xaa Xaa Leu Xaa Xaa Ser Gly Gly Gly Xaa Val Xaa Xaa Gly Xaa 
1               5                   10                  15      


Ser Leu Xaa Leu Ser Cys Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa 
            20                  25                  30          


Xaa Xaa Xaa Trp Xaa Arg Gln Xaa Xaa Xaa Xaa Xaa Gly Xaa Xaa Xaa 
        35                  40                  45              


Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Tyr Xaa 
    50                  55                  60                  


Xaa Xaa Xaa Xaa Gly Arg Phe Thr Xaa Ser Xaa Asp Xaa Xaa Xaa Xaa 
65                  70                  75                  80  


Xaa Xaa Xaa Leu Gln Met Xaa Xaa Leu Xaa Xaa Xaa Asp Thr Xaa Xaa 
                85                  90                  95      


Tyr Xaa Cys Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa 
            100                 105                 110         


Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Gly Xaa Gly Thr Gln 
        115                 120                 125             


Val Thr Val Ser Ser 
    130             


