               SEQUENCE LISTING

<110> Ebris srl

<120> ZONULIN ANTAGONISTS FOR THE TREATMENT OF MULTISYSTEM INFLAMMATORY SYNDROME IN CHILDREN (MIS-C) AND ADULTS (MIS-A)

<130> BW1157R

<160> 5

<170> BiSSAP 1.3.6

<210> 1
<211> 8
<212> PRT
<213> Artificial Sequence


<220> 
<223> Seq ID No 1 - ammino acid sequence of larazotide

<400> 1
Gly Gly Val Leu Val Gln Pro Gly 
1               5               

<210> 2
<211> 20
<212> DNA
<213> Artificial Sequence


<220> 
<223> Seq ID No 2 - CDC N1 forward primer

<400> 2
gaccccaaaa tcagcgaaat                                                20


<210> 3
<211> 24
<212> DNA
<213> Artificial Sequence


<220> 
<223> Seq ID No 3 - CDC N1 reverse primer

<400> 3
tctggttact gccagttgaa tctg                                           24


<210> 4
<211> 24
<212> DNA
<213> Artificial Sequence


<220> 
<223> Seq ID No 4 - probe

<400> 4
accccgcatt acgtttggtg gacc                                           24


<210> 5
<211> 406
<212> PRT
<213> Homo sapiens


<220> 
<223> Seq ID No 5 - ammino acid sequence of zonulin NP_005134.1

<400> 5
Met Ser Ala Leu Gly Ala Val Ile Ala Leu Leu Leu Trp Gly Gln Leu 
1               5                   10                  15      
Phe Ala Val Asp Ser Gly Asn Asp Val Thr Asp Ile Ala Asp Asp Gly 
            20                  25                  30          
Cys Pro Lys Pro Pro Glu Ile Ala His Gly Tyr Val Glu His Ser Val 
        35                  40                  45              
Arg Tyr Gln Cys Lys Asn Tyr Tyr Lys Leu Arg Thr Glu Gly Asp Gly 
    50                  55                  60                  
Val Tyr Thr Leu Asn Asp Lys Lys Gln Trp Ile Asn Lys Ala Val Gly 
65                  70                  75                  80  
Asp Lys Leu Pro Glu Cys Glu Ala Asp Asp Gly Cys Pro Lys Pro Pro 
                85                  90                  95      
Glu Ile Ala His Gly Tyr Val Glu His Ser Val Arg Tyr Gln Cys Lys 
            100                 105                 110         
Asn Tyr Tyr Lys Leu Arg Thr Glu Gly Asp Gly Val Tyr Thr Leu Asn 
        115                 120                 125             
Asn Glu Lys Gln Trp Ile Asn Lys Ala Val Gly Asp Lys Leu Pro Glu 
    130                 135                 140                 
Cys Glu Ala Val Cys Gly Lys Pro Lys Asn Pro Ala Asn Pro Val Gln 
145                 150                 155                 160 
Arg Ile Leu Gly Gly His Leu Asp Ala Lys Gly Ser Phe Pro Trp Gln 
                165                 170                 175     
Ala Lys Met Val Ser His His Asn Leu Thr Thr Gly Ala Thr Leu Ile 
            180                 185                 190         
Asn Glu Gln Trp Leu Leu Thr Thr Ala Lys Asn Leu Phe Leu Asn His 
        195                 200                 205             
Ser Glu Asn Ala Thr Ala Lys Asp Ile Ala Pro Thr Leu Thr Leu Tyr 
    210                 215                 220                 
Val Gly Lys Lys Gln Leu Val Glu Ile Glu Lys Val Val Leu His Pro 
225                 230                 235                 240 
Asn Tyr Ser Gln Val Asp Ile Gly Leu Ile Lys Leu Lys Gln Lys Val 
                245                 250                 255     
Ser Val Asn Glu Arg Val Met Pro Ile Cys Leu Pro Ser Lys Asp Tyr 
            260                 265                 270         
Ala Glu Val Gly Arg Val Gly Tyr Val Ser Gly Trp Gly Arg Asn Ala 
        275                 280                 285             
Asn Phe Lys Phe Thr Asp His Leu Lys Tyr Val Met Leu Pro Val Ala 
    290                 295                 300                 
Asp Gln Asp Gln Cys Ile Arg His Tyr Glu Gly Ser Thr Val Pro Glu 
305                 310                 315                 320 
Lys Lys Thr Pro Lys Ser Pro Val Gly Val Gln Pro Ile Leu Asn Glu 
                325                 330                 335     
His Thr Phe Cys Ala Gly Met Ser Lys Tyr Gln Glu Asp Thr Cys Tyr 
            340                 345                 350         
Gly Asp Ala Gly Ser Ala Phe Ala Val His Asp Leu Glu Glu Asp Thr 
        355                 360                 365             
Trp Tyr Ala Thr Gly Ile Leu Ser Phe Asp Lys Ser Cys Ala Val Ala 
    370                 375                 380                 
Glu Tyr Gly Val Tyr Val Lys Val Thr Ser Ile Gln Asp Trp Val Gln 
385                 390                 395                 400 
Lys Thr Ile Ala Glu Asn 
                405     

