                         SEQUENCE LISTING

<110>  IP2IPO Innovations Ltd
 
<120>  Von Willebrand Factor (VWF) Inhibitors

<130>  102109PCT1

<150>  2105625.4
<151>  2021-04-20

<160>  194   

<170>  PatentIn version 3.5

<210>  1
<211>  2813
<212>  PRT
<213>  Homo sapiens

<400>  1

Met Ile Pro Ala Arg Phe Ala Gly Val Leu Leu Ala Leu Ala Leu Ile 
1               5                   10                  15      


Leu Pro Gly Thr Leu Cys Ala Glu Gly Thr Arg Gly Arg Ser Ser Thr 
            20                  25                  30          


Ala Arg Cys Ser Leu Phe Gly Ser Asp Phe Val Asn Thr Phe Asp Gly 
        35                  40                  45              


Ser Met Tyr Ser Phe Ala Gly Tyr Cys Ser Tyr Leu Leu Ala Gly Gly 
    50                  55                  60                  


Cys Gln Lys Arg Ser Phe Ser Ile Ile Gly Asp Phe Gln Asn Gly Lys 
65                  70                  75                  80  


Arg Val Ser Leu Ser Val Tyr Leu Gly Glu Phe Phe Asp Ile His Leu 
                85                  90                  95      


Phe Val Asn Gly Thr Val Thr Gln Gly Asp Gln Arg Val Ser Met Pro 
            100                 105                 110         


Tyr Ala Ser Lys Gly Leu Tyr Leu Glu Thr Glu Ala Gly Tyr Tyr Lys 
        115                 120                 125             


Leu Ser Gly Glu Ala Tyr Gly Phe Val Ala Arg Ile Asp Gly Ser Gly 
    130                 135                 140                 


Asn Phe Gln Val Leu Leu Ser Asp Arg Tyr Phe Asn Lys Thr Cys Gly 
145                 150                 155                 160 


Leu Cys Gly Asn Phe Asn Ile Phe Ala Glu Asp Asp Phe Met Thr Gln 
                165                 170                 175     


Glu Gly Thr Leu Thr Ser Asp Pro Tyr Asp Phe Ala Asn Ser Trp Ala 
            180                 185                 190         


Leu Ser Ser Gly Glu Gln Trp Cys Glu Arg Ala Ser Pro Pro Ser Ser 
        195                 200                 205             


Ser Cys Asn Ile Ser Ser Gly Glu Met Gln Lys Gly Leu Trp Glu Gln 
    210                 215                 220                 


Cys Gln Leu Leu Lys Ser Thr Ser Val Phe Ala Arg Cys His Pro Leu 
225                 230                 235                 240 


Val Asp Pro Glu Pro Phe Val Ala Leu Cys Glu Lys Thr Leu Cys Glu 
                245                 250                 255     


Cys Ala Gly Gly Leu Glu Cys Ala Cys Pro Ala Leu Leu Glu Tyr Ala 
            260                 265                 270         


Arg Thr Cys Ala Gln Glu Gly Met Val Leu Tyr Gly Trp Thr Asp His 
        275                 280                 285             


Ser Ala Cys Ser Pro Val Cys Pro Ala Gly Met Glu Tyr Arg Gln Cys 
    290                 295                 300                 


Val Ser Pro Cys Ala Arg Thr Cys Gln Ser Leu His Ile Asn Glu Met 
305                 310                 315                 320 


Cys Gln Glu Arg Cys Val Asp Gly Cys Ser Cys Pro Glu Gly Gln Leu 
                325                 330                 335     


Leu Asp Glu Gly Leu Cys Val Glu Ser Thr Glu Cys Pro Cys Val His 
            340                 345                 350         


Ser Gly Lys Arg Tyr Pro Pro Gly Thr Ser Leu Ser Arg Asp Cys Asn 
        355                 360                 365             


Thr Cys Ile Cys Arg Asn Ser Gln Trp Ile Cys Ser Asn Glu Glu Cys 
    370                 375                 380                 


Pro Gly Glu Cys Leu Val Thr Gly Gln Ser His Phe Lys Ser Phe Asp 
385                 390                 395                 400 


Asn Arg Tyr Phe Thr Phe Ser Gly Ile Cys Gln Tyr Leu Leu Ala Arg 
                405                 410                 415     


Asp Cys Gln Asp His Ser Phe Ser Ile Val Ile Glu Thr Val Gln Cys 
            420                 425                 430         


Ala Asp Asp Arg Asp Ala Val Cys Thr Arg Ser Val Thr Val Arg Leu 
        435                 440                 445             


Pro Gly Leu His Asn Ser Leu Val Lys Leu Lys His Gly Ala Gly Val 
    450                 455                 460                 


Ala Met Asp Gly Gln Asp Val Gln Leu Pro Leu Leu Lys Gly Asp Leu 
465                 470                 475                 480 


Arg Ile Gln His Thr Val Thr Ala Ser Val Arg Leu Ser Tyr Gly Glu 
                485                 490                 495     


Asp Leu Gln Met Asp Trp Asp Gly Arg Gly Arg Leu Leu Val Lys Leu 
            500                 505                 510         


Ser Pro Val Tyr Ala Gly Lys Thr Cys Gly Leu Cys Gly Asn Tyr Asn 
        515                 520                 525             


Gly Asn Gln Gly Asp Asp Phe Leu Thr Pro Ser Gly Leu Ala Glu Pro 
    530                 535                 540                 


Arg Val Glu Asp Phe Gly Asn Ala Trp Lys Leu His Gly Asp Cys Gln 
545                 550                 555                 560 


Asp Leu Gln Lys Gln His Ser Asp Pro Cys Ala Leu Asn Pro Arg Met 
                565                 570                 575     


Thr Arg Phe Ser Glu Glu Ala Cys Ala Val Leu Thr Ser Pro Thr Phe 
            580                 585                 590         


Glu Ala Cys His Arg Ala Val Ser Pro Leu Pro Tyr Leu Arg Asn Cys 
        595                 600                 605             


Arg Tyr Asp Val Cys Ser Cys Ser Asp Gly Arg Glu Cys Leu Cys Gly 
    610                 615                 620                 


Ala Leu Ala Ser Tyr Ala Ala Ala Cys Ala Gly Arg Gly Val Arg Val 
625                 630                 635                 640 


Ala Trp Arg Glu Pro Gly Arg Cys Glu Leu Asn Cys Pro Lys Gly Gln 
                645                 650                 655     


Val Tyr Leu Gln Cys Gly Thr Pro Cys Asn Leu Thr Cys Arg Ser Leu 
            660                 665                 670         


Ser Tyr Pro Asp Glu Glu Cys Asn Glu Ala Cys Leu Glu Gly Cys Phe 
        675                 680                 685             


Cys Pro Pro Gly Leu Tyr Met Asp Glu Arg Gly Asp Cys Val Pro Lys 
    690                 695                 700                 


Ala Gln Cys Pro Cys Tyr Tyr Asp Gly Glu Ile Phe Gln Pro Glu Asp 
705                 710                 715                 720 


Ile Phe Ser Asp His His Thr Met Cys Tyr Cys Glu Asp Gly Phe Met 
                725                 730                 735     


His Cys Thr Met Ser Gly Val Pro Gly Ser Leu Leu Pro Asp Ala Val 
            740                 745                 750         


Leu Ser Ser Pro Leu Ser His Arg Ser Lys Arg Ser Leu Ser Cys Arg 
        755                 760                 765             


Pro Pro Met Val Lys Leu Val Cys Pro Ala Asp Asn Leu Arg Ala Glu 
    770                 775                 780                 


Gly Leu Glu Cys Thr Lys Thr Cys Gln Asn Tyr Asp Leu Glu Cys Met 
785                 790                 795                 800 


Ser Met Gly Cys Val Ser Gly Cys Leu Cys Pro Pro Gly Met Val Arg 
                805                 810                 815     


His Glu Asn Arg Cys Val Ala Leu Glu Arg Cys Pro Cys Phe His Gln 
            820                 825                 830         


Gly Lys Glu Tyr Ala Pro Gly Glu Thr Val Lys Ile Gly Cys Asn Thr 
        835                 840                 845             


Cys Val Cys Gln Asp Arg Lys Trp Asn Cys Thr Asp His Val Cys Asp 
    850                 855                 860                 


Ala Thr Cys Ser Thr Ile Gly Met Ala His Tyr Leu Thr Phe Asp Gly 
865                 870                 875                 880 


Leu Lys Tyr Leu Phe Pro Gly Glu Cys Gln Tyr Val Leu Val Gln Asp 
                885                 890                 895     


Tyr Cys Gly Ser Asn Pro Gly Thr Phe Arg Ile Leu Val Gly Asn Lys 
            900                 905                 910         


Gly Cys Ser His Pro Ser Val Lys Cys Lys Lys Arg Val Thr Ile Leu 
        915                 920                 925             


Val Glu Gly Gly Glu Ile Glu Leu Phe Asp Gly Glu Val Asn Val Lys 
    930                 935                 940                 


Arg Pro Met Lys Asp Glu Thr His Phe Glu Val Val Glu Ser Gly Arg 
945                 950                 955                 960 


Tyr Ile Ile Leu Leu Leu Gly Lys Ala Leu Ser Val Val Trp Asp Arg 
                965                 970                 975     


His Leu Ser Ile Ser Val Val Leu Lys Gln Thr Tyr Gln Glu Lys Val 
            980                 985                 990         


Cys Gly Leu Cys Gly Asn Phe Asp  Gly Ile Gln Asn Asn  Asp Leu Thr 
        995                 1000                 1005             


Ser Ser  Asn Leu Gln Val Glu  Glu Asp Pro Val Asp  Phe Gly Asn 
    1010                 1015                 1020             


Ser Trp  Lys Val Ser Ser Gln  Cys Ala Asp Thr Arg  Lys Val Pro 
    1025                 1030                 1035             


Leu Asp  Ser Ser Pro Ala Thr  Cys His Asn Asn Ile  Met Lys Gln 
    1040                 1045                 1050             


Thr Met  Val Asp Ser Ser Cys  Arg Ile Leu Thr Ser  Asp Val Phe 
    1055                 1060                 1065             


Gln Asp  Cys Asn Lys Leu Val  Asp Pro Glu Pro Tyr  Leu Asp Val 
    1070                 1075                 1080             


Cys Ile  Tyr Asp Thr Cys Ser  Cys Glu Ser Ile Gly  Asp Cys Ala 
    1085                 1090                 1095             


Cys Phe  Cys Asp Thr Ile Ala  Ala Tyr Ala His Val  Cys Ala Gln 
    1100                 1105                 1110             


His Gly  Lys Val Val Thr Trp  Arg Thr Ala Thr Leu  Cys Pro Gln 
    1115                 1120                 1125             


Ser Cys  Glu Glu Arg Asn Leu  Arg Glu Asn Gly Tyr  Glu Cys Glu 
    1130                 1135                 1140             


Trp Arg  Tyr Asn Ser Cys Ala  Pro Ala Cys Gln Val  Thr Cys Gln 
    1145                 1150                 1155             


His Pro  Glu Pro Leu Ala Cys  Pro Val Gln Cys Val  Glu Gly Cys 
    1160                 1165                 1170             


His Ala  His Cys Pro Pro Gly  Lys Ile Leu Asp Glu  Leu Leu Gln 
    1175                 1180                 1185             


Thr Cys  Val Asp Pro Glu Asp  Cys Pro Val Cys Glu  Val Ala Gly 
    1190                 1195                 1200             


Arg Arg  Phe Ala Ser Gly Lys  Lys Val Thr Leu Asn  Pro Ser Asp 
    1205                 1210                 1215             


Pro Glu  His Cys Gln Ile Cys  His Cys Asp Val Val  Asn Leu Thr 
    1220                 1225                 1230             


Cys Glu  Ala Cys Gln Glu Pro  Gly Gly Leu Val Val  Pro Pro Thr 
    1235                 1240                 1245             


Asp Ala  Pro Val Ser Pro Thr  Thr Leu Tyr Val Glu  Asp Ile Ser 
    1250                 1255                 1260             


Glu Pro  Pro Leu His Asp Phe  Tyr Cys Ser Arg Leu  Leu Asp Leu 
    1265                 1270                 1275             


Val Phe  Leu Leu Asp Gly Ser  Ser Arg Leu Ser Glu  Ala Glu Phe 
    1280                 1285                 1290             


Glu Val  Leu Lys Ala Phe Val  Val Asp Met Met Glu  Arg Leu Arg 
    1295                 1300                 1305             


Ile Ser  Gln Lys Trp Val Arg  Val Ala Val Val Glu  Tyr His Asp 
    1310                 1315                 1320             


Gly Ser  His Ala Tyr Ile Gly  Leu Lys Asp Arg Lys  Arg Pro Ser 
    1325                 1330                 1335             


Glu Leu  Arg Arg Ile Ala Ser  Gln Val Lys Tyr Ala  Gly Ser Gln 
    1340                 1345                 1350             


Val Ala  Ser Thr Ser Glu Val  Leu Lys Tyr Thr Leu  Phe Gln Ile 
    1355                 1360                 1365             


Phe Ser  Lys Ile Asp Arg Pro  Glu Ala Ser Arg Ile  Thr Leu Leu 
    1370                 1375                 1380             


Leu Met  Ala Ser Gln Glu Pro  Gln Arg Met Ser Arg  Asn Phe Val 
    1385                 1390                 1395             


Arg Tyr  Val Gln Gly Leu Lys  Lys Lys Lys Val Ile  Val Ile Pro 
    1400                 1405                 1410             


Val Gly  Ile Gly Pro His Ala  Asn Leu Lys Gln Ile  Arg Leu Ile 
    1415                 1420                 1425             


Glu Lys  Gln Ala Pro Glu Asn  Lys Ala Phe Val Leu  Ser Ser Val 
    1430                 1435                 1440             


Asp Glu  Leu Glu Gln Gln Arg  Asp Glu Ile Val Ser  Tyr Leu Cys 
    1445                 1450                 1455             


Asp Leu  Ala Pro Glu Ala Pro  Pro Pro Thr Leu Pro  Pro Asp Met 
    1460                 1465                 1470             


Ala Gln  Val Thr Val Gly Pro  Gly Leu Leu Gly Val  Ser Thr Leu 
    1475                 1480                 1485             


Gly Pro  Lys Arg Asn Ser Met  Val Leu Asp Val Ala  Phe Val Leu 
    1490                 1495                 1500             


Glu Gly  Ser Asp Lys Ile Gly  Glu Ala Asp Phe Asn  Arg Ser Lys 
    1505                 1510                 1515             


Glu Phe  Met Glu Glu Val Ile  Gln Arg Met Asp Val  Gly Gln Asp 
    1520                 1525                 1530             


Ser Ile  His Val Thr Val Leu  Gln Tyr Ser Tyr Met  Val Thr Val 
    1535                 1540                 1545             


Glu Tyr  Pro Phe Ser Glu Ala  Gln Ser Lys Gly Asp  Ile Leu Gln 
    1550                 1555                 1560             


Arg Val  Arg Glu Ile Arg Tyr  Gln Gly Gly Asn Arg  Thr Asn Thr 
    1565                 1570                 1575             


Gly Leu  Ala Leu Arg Tyr Leu  Ser Asp His Ser Phe  Leu Val Ser 
    1580                 1585                 1590             


Gln Gly  Asp Arg Glu Gln Ala  Pro Asn Leu Val Tyr  Met Val Thr 
    1595                 1600                 1605             


Gly Asn  Pro Ala Ser Asp Glu  Ile Lys Arg Leu Pro  Gly Asp Ile 
    1610                 1615                 1620             


Gln Val  Val Pro Ile Gly Val  Gly Pro Asn Ala Asn  Val Gln Glu 
    1625                 1630                 1635             


Leu Glu  Arg Ile Gly Trp Pro  Asn Ala Pro Ile Leu  Ile Gln Asp 
    1640                 1645                 1650             


Phe Glu  Thr Leu Pro Arg Glu  Ala Pro Asp Leu Val  Leu Gln Arg 
    1655                 1660                 1665             


Cys Cys  Ser Gly Glu Gly Leu  Gln Ile Pro Thr Leu  Ser Pro Ala 
    1670                 1675                 1680             


Pro Asp  Cys Ser Gln Pro Leu  Asp Val Ile Leu Leu  Leu Asp Gly 
    1685                 1690                 1695             


Ser Ser  Ser Phe Pro Ala Ser  Tyr Phe Asp Glu Met  Lys Ser Phe 
    1700                 1705                 1710             


Ala Lys  Ala Phe Ile Ser Lys  Ala Asn Ile Gly Pro  Arg Leu Thr 
    1715                 1720                 1725             


Gln Val  Ser Val Leu Gln Tyr  Gly Ser Ile Thr Thr  Ile Asp Val 
    1730                 1735                 1740             


Pro Trp  Asn Val Val Pro Glu  Lys Ala His Leu Leu  Ser Leu Val 
    1745                 1750                 1755             


Asp Val  Met Gln Arg Glu Gly  Gly Pro Ser Gln Ile  Gly Asp Ala 
    1760                 1765                 1770             


Leu Gly  Phe Ala Val Arg Tyr  Leu Thr Ser Glu Met  His Gly Ala 
    1775                 1780                 1785             


Arg Pro  Gly Ala Ser Lys Ala  Val Val Ile Leu Val  Thr Asp Val 
    1790                 1795                 1800             


Ser Val  Asp Ser Val Asp Ala  Ala Ala Asp Ala Ala  Arg Ser Asn 
    1805                 1810                 1815             


Arg Val  Thr Val Phe Pro Ile  Gly Ile Gly Asp Arg  Tyr Asp Ala 
    1820                 1825                 1830             


Ala Gln  Leu Arg Ile Leu Ala  Gly Pro Ala Gly Asp  Ser Asn Val 
    1835                 1840                 1845             


Val Lys  Leu Gln Arg Ile Glu  Asp Leu Pro Thr Met  Val Thr Leu 
    1850                 1855                 1860             


Gly Asn  Ser Phe Leu His Lys  Leu Cys Ser Gly Phe  Val Arg Ile 
    1865                 1870                 1875             


Cys Met  Asp Glu Asp Gly Asn  Glu Lys Arg Pro Gly  Asp Val Trp 
    1880                 1885                 1890             


Thr Leu  Pro Asp Gln Cys His  Thr Val Thr Cys Gln  Pro Asp Gly 
    1895                 1900                 1905             


Gln Thr  Leu Leu Lys Ser His  Arg Val Asn Cys Asp  Arg Gly Leu 
    1910                 1915                 1920             


Arg Pro  Ser Cys Pro Asn Ser  Gln Ser Pro Val Lys  Val Glu Glu 
    1925                 1930                 1935             


Thr Cys  Gly Cys Arg Trp Thr  Cys Pro Cys Val Cys  Thr Gly Ser 
    1940                 1945                 1950             


Ser Thr  Arg His Ile Val Thr  Phe Asp Gly Gln Asn  Phe Lys Leu 
    1955                 1960                 1965             


Thr Gly  Ser Cys Ser Tyr Val  Leu Phe Gln Asn Lys  Glu Gln Asp 
    1970                 1975                 1980             


Leu Glu  Val Ile Leu His Asn  Gly Ala Cys Ser Pro  Gly Ala Arg 
    1985                 1990                 1995             


Gln Gly  Cys Met Lys Ser Ile  Glu Val Lys His Ser  Ala Leu Ser 
    2000                 2005                 2010             


Val Glu  Leu His Ser Asp Met  Glu Val Thr Val Asn  Gly Arg Leu 
    2015                 2020                 2025             


Val Ser  Val Pro Tyr Val Gly  Gly Asn Met Glu Val  Asn Val Tyr 
    2030                 2035                 2040             


Gly Ala  Ile Met His Glu Val  Arg Phe Asn His Leu  Gly His Ile 
    2045                 2050                 2055             


Phe Thr  Phe Thr Pro Gln Asn  Asn Glu Phe Gln Leu  Gln Leu Ser 
    2060                 2065                 2070             


Pro Lys  Thr Phe Ala Ser Lys  Thr Tyr Gly Leu Cys  Gly Ile Cys 
    2075                 2080                 2085             


Asp Glu  Asn Gly Ala Asn Asp  Phe Met Leu Arg Asp  Gly Thr Val 
    2090                 2095                 2100             


Thr Thr  Asp Trp Lys Thr Leu  Val Gln Glu Trp Thr  Val Gln Arg 
    2105                 2110                 2115             


Pro Gly  Gln Thr Cys Gln Pro  Ile Leu Glu Glu Gln  Cys Leu Val 
    2120                 2125                 2130             


Pro Asp  Ser Ser His Cys Gln  Val Leu Leu Leu Pro  Leu Phe Ala 
    2135                 2140                 2145             


Glu Cys  His Lys Val Leu Ala  Pro Ala Thr Phe Tyr  Ala Ile Cys 
    2150                 2155                 2160             


Gln Gln  Asp Ser Cys His Gln  Glu Gln Val Cys Glu  Val Ile Ala 
    2165                 2170                 2175             


Ser Tyr  Ala His Leu Cys Arg  Thr Asn Gly Val Cys  Val Asp Trp 
    2180                 2185                 2190             


Arg Thr  Pro Asp Phe Cys Ala  Met Ser Cys Pro Pro  Ser Leu Val 
    2195                 2200                 2205             


Tyr Asn  His Cys Glu His Gly  Cys Pro Arg His Cys  Asp Gly Asn 
    2210                 2215                 2220             


Val Ser  Ser Cys Gly Asp His  Pro Ser Glu Gly Cys  Phe Cys Pro 
    2225                 2230                 2235             


Pro Asp  Lys Val Met Leu Glu  Gly Ser Cys Val Pro  Glu Glu Ala 
    2240                 2245                 2250             


Cys Thr  Gln Cys Ile Gly Glu  Asp Gly Val Gln His  Gln Phe Leu 
    2255                 2260                 2265             


Glu Ala  Trp Val Pro Asp His  Gln Pro Cys Gln Ile  Cys Thr Cys 
    2270                 2275                 2280             


Leu Ser  Gly Arg Lys Val Asn  Cys Thr Thr Gln Pro  Cys Pro Thr 
    2285                 2290                 2295             


Ala Lys  Ala Pro Thr Cys Gly  Leu Cys Glu Val Ala  Arg Leu Arg 
    2300                 2305                 2310             


Gln Asn  Ala Asp Gln Cys Cys  Pro Glu Tyr Glu Cys  Val Cys Asp 
    2315                 2320                 2325             


Pro Val  Ser Cys Asp Leu Pro  Pro Val Pro His Cys  Glu Arg Gly 
    2330                 2335                 2340             


Leu Gln  Pro Thr Leu Thr Asn  Pro Gly Glu Cys Arg  Pro Asn Phe 
    2345                 2350                 2355             


Thr Cys  Ala Cys Arg Lys Glu  Glu Cys Lys Arg Val  Ser Pro Pro 
    2360                 2365                 2370             


Ser Cys  Pro Pro His Arg Leu  Pro Thr Leu Arg Lys  Thr Gln Cys 
    2375                 2380                 2385             


Cys Asp  Glu Tyr Glu Cys Ala  Cys Asn Cys Val Asn  Ser Thr Val 
    2390                 2395                 2400             


Ser Cys  Pro Leu Gly Tyr Leu  Ala Ser Thr Ala Thr  Asn Asp Cys 
    2405                 2410                 2415             


Gly Cys  Thr Thr Thr Thr Cys  Leu Pro Asp Lys Val  Cys Val His 
    2420                 2425                 2430             


Arg Ser  Thr Ile Tyr Pro Val  Gly Gln Phe Trp Glu  Glu Gly Cys 
    2435                 2440                 2445             


Asp Val  Cys Thr Cys Thr Asp  Met Glu Asp Ala Val  Met Gly Leu 
    2450                 2455                 2460             


Arg Val  Ala Gln Cys Ser Gln  Lys Pro Cys Glu Asp  Ser Cys Arg 
    2465                 2470                 2475             


Ser Gly  Phe Thr Tyr Val Leu  His Glu Gly Glu Cys  Cys Gly Arg 
    2480                 2485                 2490             


Cys Leu  Pro Ser Ala Cys Glu  Val Val Thr Gly Ser  Pro Arg Gly 
    2495                 2500                 2505             


Asp Ser  Gln Ser Ser Trp Lys  Ser Val Gly Ser Gln  Trp Ala Ser 
    2510                 2515                 2520             


Pro Glu  Asn Pro Cys Leu Ile  Asn Glu Cys Val Arg  Val Lys Glu 
    2525                 2530                 2535             


Glu Val  Phe Ile Gln Gln Arg  Asn Val Ser Cys Pro  Gln Leu Glu 
    2540                 2545                 2550             


Val Pro  Val Cys Pro Ser Gly  Phe Gln Leu Ser Cys  Lys Thr Ser 
    2555                 2560                 2565             


Ala Cys  Cys Pro Ser Cys Arg  Cys Glu Arg Met Glu  Ala Cys Met 
    2570                 2575                 2580             


Leu Asn  Gly Thr Val Ile Gly  Pro Gly Lys Thr Val  Met Ile Asp 
    2585                 2590                 2595             


Val Cys  Thr Thr Cys Arg Cys  Met Val Gln Val Gly  Val Ile Ser 
    2600                 2605                 2610             


Gly Phe  Lys Leu Glu Cys Arg  Lys Thr Thr Cys Asn  Pro Cys Pro 
    2615                 2620                 2625             


Leu Gly  Tyr Lys Glu Glu Asn  Asn Thr Gly Glu Cys  Cys Gly Arg 
    2630                 2635                 2640             


Cys Leu  Pro Thr Ala Cys Thr  Ile Gln Leu Arg Gly  Gly Gln Ile 
    2645                 2650                 2655             


Met Thr  Leu Lys Arg Asp Glu  Thr Leu Gln Asp Gly  Cys Asp Thr 
    2660                 2665                 2670             


His Phe  Cys Lys Val Asn Glu  Arg Gly Glu Tyr Phe  Trp Glu Lys 
    2675                 2680                 2685             


Arg Val  Thr Gly Cys Pro Pro  Phe Asp Glu His Lys  Cys Leu Ala 
    2690                 2695                 2700             


Glu Gly  Gly Lys Ile Met Lys  Ile Pro Gly Thr Cys  Cys Asp Thr 
    2705                 2710                 2715             


Cys Glu  Glu Pro Glu Cys Asn  Asp Ile Thr Ala Arg  Leu Gln Tyr 
    2720                 2725                 2730             


Val Lys  Val Gly Ser Cys Lys  Ser Glu Val Glu Val  Asp Ile His 
    2735                 2740                 2745             


Tyr Cys  Gln Gly Lys Cys Ala  Ser Lys Ala Met Tyr  Ser Ile Asp 
    2750                 2755                 2760             


Ile Asn  Asp Val Gln Asp Gln  Cys Ser Cys Cys Ser  Pro Thr Arg 
    2765                 2770                 2775             


Thr Glu  Pro Met Gln Val Ala  Leu His Cys Thr Asn  Gly Ser Val 
    2780                 2785                 2790             


Val Tyr  His Glu Val Leu Asn  Ala Met Glu Cys Lys  Cys Ser Pro 
    2795                 2800                 2805             


Arg Lys  Cys Ser Lys 
    2810             


<210>  2
<211>  468
<212>  PRT
<213>  Homo sapiens

<400>  2

Thr Gln Cys Ile Gly Glu Asp Gly Val Gln His Gln Phe Leu Glu Ala 
1               5                   10                  15      


Trp Val Pro Asp His Gln Pro Cys Gln Ile Cys Thr Cys Leu Ser Gly 
            20                  25                  30          


Arg Lys Val Asn Cys Thr Thr Gln Pro Cys Pro Thr Ala Lys Ala Pro 
        35                  40                  45              


Thr Cys Gly Leu Cys Glu Val Ala Arg Leu Arg Gln Asn Ala Asp Gln 
    50                  55                  60                  


Cys Cys Pro Glu Tyr Glu Cys Val Cys Asp Pro Val Ser Cys Asp Leu 
65                  70                  75                  80  


Pro Pro Val Pro His Cys Glu Arg Gly Leu Gln Pro Thr Leu Thr Asn 
                85                  90                  95      


Pro Gly Glu Cys Arg Pro Asn Phe Thr Cys Ala Cys Arg Lys Glu Glu 
            100                 105                 110         


Cys Lys Arg Val Ser Pro Pro Ser Cys Pro Pro His Arg Leu Pro Thr 
        115                 120                 125             


Leu Arg Lys Thr Gln Cys Cys Asp Glu Tyr Glu Cys Ala Cys Asn Cys 
    130                 135                 140                 


Val Asn Ser Thr Val Ser Cys Pro Leu Gly Tyr Leu Ala Ser Thr Ala 
145                 150                 155                 160 


Thr Asn Asp Cys Gly Cys Thr Thr Thr Thr Cys Leu Pro Asp Lys Val 
                165                 170                 175     


Cys Val His Arg Ser Thr Ile Tyr Pro Val Gly Gln Phe Trp Glu Glu 
            180                 185                 190         


Gly Cys Asp Val Cys Thr Cys Thr Asp Met Glu Asp Ala Val Met Gly 
        195                 200                 205             


Leu Arg Val Ala Gln Cys Ser Gln Lys Pro Cys Glu Asp Ser Cys Arg 
    210                 215                 220                 


Ser Gly Phe Thr Tyr Val Leu His Glu Gly Glu Cys Cys Gly Arg Cys 
225                 230                 235                 240 


Leu Pro Ser Ala Cys Glu Val Val Thr Gly Ser Pro Arg Gly Asp Ser 
                245                 250                 255     


Gln Ser Ser Trp Lys Ser Val Gly Ser Gln Trp Ala Ser Pro Glu Asn 
            260                 265                 270         


Pro Cys Leu Ile Asn Glu Cys Val Arg Val Lys Glu Glu Val Phe Ile 
        275                 280                 285             


Gln Gln Arg Asn Val Ser Cys Pro Gln Leu Glu Val Pro Val Cys Pro 
    290                 295                 300                 


Ser Gly Phe Gln Leu Ser Cys Lys Thr Ser Ala Cys Cys Pro Ser Cys 
305                 310                 315                 320 


Arg Cys Glu Arg Met Glu Ala Cys Met Leu Asn Gly Thr Val Ile Gly 
                325                 330                 335     


Pro Gly Lys Thr Val Met Ile Asp Val Cys Thr Thr Cys Arg Cys Met 
            340                 345                 350         


Val Gln Val Gly Val Ile Ser Gly Phe Lys Leu Glu Cys Arg Lys Thr 
        355                 360                 365             


Thr Cys Asn Pro Cys Pro Leu Gly Tyr Lys Glu Glu Asn Asn Thr Gly 
    370                 375                 380                 


Glu Cys Cys Gly Arg Cys Leu Pro Thr Ala Cys Thr Ile Gln Leu Arg 
385                 390                 395                 400 


Gly Gly Gln Ile Met Thr Leu Lys Arg Asp Glu Thr Leu Gln Asp Gly 
                405                 410                 415     


Cys Asp Thr His Phe Cys Lys Val Asn Glu Arg Gly Glu Tyr Phe Trp 
            420                 425                 430         


Glu Lys Arg Val Thr Gly Cys Pro Pro Phe Asp Glu His Lys Cys Leu 
        435                 440                 445             


Ala Glu Gly Gly Lys Ile Met Lys Ile Pro Gly Thr Cys Cys Asp Thr 
    450                 455                 460                 


Cys Glu Glu Pro 
465             


<210>  3
<211>  79
<212>  PRT
<213>  Homo sapiens

<400>  3

Thr Gln Cys Ile Gly Glu Asp Gly Val Gln His Gln Phe Leu Glu Ala 
1               5                   10                  15      


Trp Val Pro Asp His Gln Pro Cys Gln Ile Cys Thr Cys Leu Ser Gly 
            20                  25                  30          


Arg Lys Val Asn Cys Thr Thr Gln Pro Cys Pro Thr Ala Lys Ala Pro 
        35                  40                  45              


Thr Cys Gly Leu Cys Glu Val Ala Arg Leu Arg Gln Asn Ala Asp Gln 
    50                  55                  60                  


Cys Cys Pro Glu Tyr Glu Cys Val Cys Asp Pro Val Ser Cys Asp 
65                  70                  75                  


<210>  4
<211>  69
<212>  PRT
<213>  Homo sapiens

<400>  4

Leu Pro Pro Val Pro His Cys Glu Arg Gly Leu Gln Pro Thr Leu Thr 
1               5                   10                  15      


Asn Pro Gly Glu Cys Arg Pro Asn Phe Thr Cys Ala Cys Arg Lys Glu 
            20                  25                  30          


Glu Cys Lys Arg Val Ser Pro Pro Ser Cys Pro Pro His Arg Leu Pro 
        35                  40                  45              


Thr Leu Arg Lys Thr Gln Cys Cys Asp Glu Tyr Glu Cys Ala Cys Asn 
    50                  55                  60                  


Cys Val Asn Ser Thr 
65                  


<210>  5
<211>  67
<212>  PRT
<213>  Homo sapiens

<400>  5

Val Cys Val His Arg Ser Thr Ile Tyr Pro Val Gly Gln Phe Trp Glu 
1               5                   10                  15      


Glu Gly Cys Asp Val Cys Thr Cys Thr Asp Met Glu Asp Ala Val Met 
            20                  25                  30          


Gly Leu Arg Val Ala Gln Cys Ser Gln Lys Pro Cys Glu Asp Ser Cys 
        35                  40                  45              


Arg Ser Gly Phe Thr Tyr Val Leu His Glu Gly Glu Cys Cys Gly Arg 
    50                  55                  60                  


Cys Leu Pro 
65          


<210>  6
<211>  81
<212>  PRT
<213>  Homo sapiens

<400>  6

Ser Ala Cys Glu Val Val Thr Gly Ser Pro Arg Gly Asp Ser Gln Ser 
1               5                   10                  15      


Ser Trp Lys Ser Val Gly Ser Gln Trp Ala Ser Pro Glu Asn Pro Cys 
            20                  25                  30          


Leu Ile Asn Glu Cys Val Arg Val Lys Glu Glu Val Phe Ile Gln Gln 
        35                  40                  45              


Arg Asn Val Ser Cys Pro Gln Leu Glu Val Pro Val Cys Pro Ser Gly 
    50                  55                  60                  


Phe Gln Leu Ser Cys Lys Thr Ser Ala Cys Cys Pro Ser Cys Arg Cys 
65                  70                  75                  80  


Glu 
    


<210>  7
<211>  69
<212>  PRT
<213>  Homo sapiens

<400>  7

Arg Met Glu Ala Cys Met Leu Asn Gly Thr Val Ile Gly Pro Gly Lys 
1               5                   10                  15      


Thr Val Met Ile Asp Val Cys Thr Thr Cys Arg Cys Met Val Gln Val 
            20                  25                  30          


Gly Val Ile Ser Gly Phe Lys Leu Glu Cys Arg Lys Thr Thr Cys Asn 
        35                  40                  45              


Pro Cys Pro Leu Gly Tyr Lys Glu Glu Asn Asn Thr Gly Glu Cys Cys 
    50                  55                  60                  


Gly Arg Cys Leu Pro 
65                  


<210>  8
<211>  76
<212>  PRT
<213>  Homo sapiens

<400>  8

Thr Ala Cys Thr Ile Gln Leu Arg Gly Gly Gln Ile Met Thr Leu Lys 
1               5                   10                  15      


Arg Asp Glu Thr Leu Gln Asp Gly Cys Asp Thr His Phe Cys Lys Val 
            20                  25                  30          


Asn Glu Arg Gly Glu Tyr Phe Trp Glu Lys Arg Val Thr Gly Cys Pro 
        35                  40                  45              


Pro Phe Asp Glu His Lys Cys Leu Ala Glu Gly Gly Lys Ile Met Lys 
    50                  55                  60                  


Ile Pro Gly Thr Cys Cys Asp Thr Cys Glu Glu Pro 
65                  70                  75      


<210>  9
<211>  8
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  1-A2 CDR-H1

<400>  9

Gly Ile Asp Leu Thr Ser Asn Ala 
1               5               


<210>  10
<211>  7
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  1-A2 CDR-H2

<400>  10

Ile Tyr Gly His Asp Thr Ser 
1               5           


<210>  11
<211>  9
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  1-A2 CDR-H3

<400>  11

Ala Arg Gly Phe Ile Tyr Phe Asp Ile 
1               5                   


<210>  12
<211>  25
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  1-A2 FR-H1

<400>  12

Ser Gln Ser Val Glu Glu Ser Gly Gly Arg Leu Val Pro Pro Gly Thr 
1               5                   10                  15      


Pro Leu Thr Leu Thr Cys Thr Val Ser 
            20                  25  


<210>  13
<211>  17
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  1-A2 FR-H2

<400>  13

Met Asn Trp Val Arg Gln Ala Pro Gly Lys Gly Leu Glu Trp Ile Gly 
1               5                   10                  15      


Gly 
    


<210>  14
<211>  36
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  1-A2 FR-H3

<400>  14

Tyr Tyr Ala Ala Trp Ala Lys Gly Arg Phe Thr Ile Ser Arg Thr Ser 
1               5                   10                  15      


Thr Thr Val Asp Leu Lys Met Thr Arg Pro Thr Thr Asp Asp Thr Ala 
            20                  25                  30          


Thr Tyr Phe Cys 
        35      


<210>  15
<211>  11
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  1-A2 FR-H4

<400>  15

Trp Gly Thr Gly Thr Leu Val Thr Ile Ser Ser 
1               5                   10      


<210>  16
<211>  112
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  1-A2 VH

<400>  16

Gln Ser Val Glu Glu Ser Gly Gly Arg Leu Val Pro Pro Gly Thr Pro 
1               5                   10                  15      


Leu Thr Leu Thr Cys Thr Val Ser Gly Ile Asp Leu Thr Ser Asn Ala 
            20                  25                  30          


Met Asn Trp Val Arg Gln Ala Pro Gly Lys Gly Leu Glu Trp Ile Gly 
        35                  40                  45              


Gly Ile Tyr Gly His Asp Thr Ser Tyr Tyr Ala Ala Trp Ala Lys Gly 
    50                  55                  60                  


Arg Phe Thr Ile Ser Arg Thr Ser Thr Thr Val Asp Leu Lys Met Thr 
65                  70                  75                  80  


Arg Pro Thr Thr Asp Asp Thr Ala Thr Tyr Phe Cys Ala Arg Gly Phe 
                85                  90                  95      


Ile Tyr Phe Asp Ile Trp Gly Thr Gly Thr Leu Val Thr Ile Ser Ser 
            100                 105                 110         


<210>  17
<211>  336
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  1-A2 VH

<400>  17
cagtcggtgg aggagtccgg gggtcgcctg gtcccgcctg ggacacccct gacactcacc       60

tgcacagtct ctggaatcga cctcactagc aatgcaatga actgggtccg ccaggctcca      120

gggaaggggc tggaatggat cggaggcatt tatggtcatg atacctcata ttacgcggcc      180

tgggcgaaag gccgattcac catctccaga acctcgacca cagtggatct gaaaatgacc      240

aggccgacaa ccgacgacac ggccacctat ttctgtgcca gaggttttat ttattttgac      300

atctggggca caggcaccct ggtcaccatc tcttca                                336


<210>  18
<211>  6
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  1-A2 CDR-L1

<400>  18

Glu Asp Ile Tyr Ser Gly 
1               5       


<210>  19
<211>  3
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  1-A2 CDR-L2

<400>  19

Gly Ala Ser 
1           


<210>  20
<211>  12
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  1-A2 CDR-L3

<400>  20

Leu Gly Gly His Ser His Ser Thr Thr Asp Leu Thr 
1               5                   10          


<210>  21
<211>  26
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  1-A2 FR-L1

<400>  21

Ala Ile Glu Met Thr Gln Thr Pro Pro Ser Leu Ser Ala Ser Val Gly 
1               5                   10                  15      


Glu Thr Val Arg Ile Arg Cys Leu Ala Ser 
            20                  25      


<210>  22
<211>  17
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  1-A2 FR-L2

<400>  22

Ile Ser Trp Tyr Gln Gln Lys Pro Gly Lys Pro Pro Thr Leu Leu Ile 
1               5                   10                  15      


Tyr 
    


<210>  23
<211>  36
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  1-A2 FR-L3

<400>  23

Asn Leu Glu Ser Gly Val Pro Pro Arg Phe Ser Gly Ser Gly Ser Gly 
1               5                   10                  15      


Thr Asp Tyr Thr Leu Thr Ile Gly Gly Val Gln Ala Glu Asp Ala Ala 
            20                  25                  30          


Thr Tyr Tyr Cys 
        35      


<210>  24
<211>  10
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  1-A2 FR-L4

<400>  24

Phe Gly Ala Gly Thr Lys Val Glu Ile Lys 
1               5                   10  


<210>  25
<211>  110
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  1-A2 VL

<400>  25

Ala Ile Glu Met Thr Gln Thr Pro Pro Ser Leu Ser Ala Ser Val Gly 
1               5                   10                  15      


Glu Thr Val Arg Ile Arg Cys Leu Ala Ser Glu Asp Ile Tyr Ser Gly 
            20                  25                  30          


Ile Ser Trp Tyr Gln Gln Lys Pro Gly Lys Pro Pro Thr Leu Leu Ile 
        35                  40                  45              


Tyr Gly Ala Ser Asn Leu Glu Ser Gly Val Pro Pro Arg Phe Ser Gly 
    50                  55                  60                  


Ser Gly Ser Gly Thr Asp Tyr Thr Leu Thr Ile Gly Gly Val Gln Ala 
65                  70                  75                  80  


Glu Asp Ala Ala Thr Tyr Tyr Cys Leu Gly Gly His Ser His Ser Thr 
                85                  90                  95      


Thr Asp Leu Thr Phe Gly Ala Gly Thr Lys Val Glu Ile Lys 
            100                 105                 110 


<210>  26
<211>  330
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  1-A2 VL

<400>  26
gcaattgaga tgacccagac tccaccctcc ctgtctgcat ctgtgggaga aactgtcagg       60

attaggtgcc tggccagtga ggacatttac agtggtatat cctggtatca acagaagcca      120

gggaaacctc ctacactcct gatctatggt gcatccaatt tagaatctgg ggtcccacca      180

cggttcagtg gcagtggatc tgggacagat tacaccctca ccattggcgg cgtgcaggct      240

gaagatgctg ccacctacta ctgtctaggc ggtcatagcc acagtactac cgatttgact      300

tttggagctg ggaccaaggt ggaaatcaaa                                       330


<210>  27
<211>  8
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  4-H3 CDR-H1

<400>  27

Gly Ile Asp Leu Thr Ser Asn Ala 
1               5               


<210>  28
<211>  7
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  4-H3 CDR-H2

<400>  28

Ile Tyr Gly His Asp Thr Ser 
1               5           


<210>  29
<211>  9
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  4-H3 CDR-H3

<400>  29

Ala Arg Gly Phe Ile Tyr Phe Asp Ile 
1               5                   


<210>  30
<211>  25
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  4-H3 FR-H1

<400>  30

Ser Gln Ser Leu Glu Glu Ser Gly Gly Arg Leu Val Pro Pro Gly Thr 
1               5                   10                  15      


Pro Leu Thr Leu Thr Cys Thr Val Ser 
            20                  25  


<210>  31
<211>  17
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  4-H3 FR-H2

<400>  31

Met Asn Trp Val Arg Gln Ala Pro Gly Lys Gly Leu Glu Trp Ile Gly 
1               5                   10                  15      


Gly 
    


<210>  32
<211>  36
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  4-H3 FR-H3

<400>  32

Tyr Tyr Ala Ala Trp Ala Lys Gly Arg Phe Thr Ile Ser Arg Thr Ser 
1               5                   10                  15      


Thr Thr Val Asp Leu Lys Met Thr Arg Pro Thr Thr Asp Asp Thr Ala 
            20                  25                  30          


Thr Tyr Phe Cys 
        35      


<210>  33
<211>  11
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  4-H3 FR-H4

<400>  33

Trp Gly Thr Gly Thr Leu Val Thr Ile Ser Ser 
1               5                   10      


<210>  34
<211>  112
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  4-H3 VH

<400>  34

Gln Ser Leu Glu Glu Ser Gly Gly Arg Leu Val Pro Pro Gly Thr Pro 
1               5                   10                  15      


Leu Thr Leu Thr Cys Thr Val Ser Gly Ile Asp Leu Thr Ser Asn Ala 
            20                  25                  30          


Met Asn Trp Val Arg Gln Ala Pro Gly Lys Gly Leu Glu Trp Ile Gly 
        35                  40                  45              


Gly Ile Tyr Gly His Asp Thr Ser Tyr Tyr Ala Ala Trp Ala Lys Gly 
    50                  55                  60                  


Arg Phe Thr Ile Ser Arg Thr Ser Thr Thr Val Asp Leu Lys Met Thr 
65                  70                  75                  80  


Arg Pro Thr Thr Asp Asp Thr Ala Thr Tyr Phe Cys Ala Arg Gly Phe 
                85                  90                  95      


Ile Tyr Phe Asp Ile Trp Gly Thr Gly Thr Leu Val Thr Ile Ser Ser 
            100                 105                 110         


<210>  35
<211>  336
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  4-H3 VH

<400>  35
cagtcgctgg aggagtccgg gggtcgcctg gtcccgcctg ggacacccct gacactcacc       60

tgcacagtct ctggaatcga cctcactagc aatgcaatga actgggtccg ccaggctcca      120

gggaaggggc tggaatggat cggaggcatt tatggtcatg atacctcata ttacgcggcc      180

tgggcgaaag gccgattcac catctccaga acctcgacca cagtggatct gaaaatgacc      240

aggccgacaa ccgacgacac ggccacctat ttctgtgcca gaggttttat ttattttgac      300

atctggggca caggcaccct ggtcaccatc tcttca                                336


<210>  36
<211>  6
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  4-H3 CDR-L1

<400>  36

Glu Asp Ile Ala Ser Gly 
1               5       


<210>  37
<211>  3
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  4-H3 CDR-L2

<400>  37

Gly Ala Ser 
1           


<210>  38
<211>  12
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  4-H3 CDR-L3

<400>  38

Leu Gly Gly Tyr Ser Phe Ser Ser Asn Gly Leu Thr 
1               5                   10          


<210>  39
<211>  26
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  4-H3 FR-L1

<400>  39

Ala Tyr Asp Met Thr Gln Thr Pro Pro Ser Leu Ser Ala Ser Val Gly 
1               5                   10                  15      


Glu Thr Val Arg Ile Arg Cys Leu Ala Ser 
            20                  25      


<210>  40
<211>  17
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  4-H3 FR-L2

<400>  40

Ile Ser Trp Tyr Gln Gln Lys Pro Gly Lys Pro Pro Thr Leu Leu Ile 
1               5                   10                  15      


Tyr 
    


<210>  41
<211>  36
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  4-H3 FR-L3

<400>  41

Asn Leu Glu Ser Gly Val Pro Pro Arg Phe Ser Gly Ser Gly Ser Gly 
1               5                   10                  15      


Thr Asp Tyr Thr Leu Thr Ile Gly Gly Val Gln Ala Glu Asp Ala Ala 
            20                  25                  30          


Thr Tyr Tyr Cys 
        35      


<210>  42
<211>  10
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  4-H3 FR-L4

<400>  42

Phe Gly Ala Gly Thr Lys Val Glu Ile Lys 
1               5                   10  


<210>  43
<211>  110
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  4-H3 VL

<400>  43

Ala Tyr Asp Met Thr Gln Thr Pro Pro Ser Leu Ser Ala Ser Val Gly 
1               5                   10                  15      


Glu Thr Val Arg Ile Arg Cys Leu Ala Ser Glu Asp Ile Ala Ser Gly 
            20                  25                  30          


Ile Ser Trp Tyr Gln Gln Lys Pro Gly Lys Pro Pro Thr Leu Leu Ile 
        35                  40                  45              


Tyr Gly Ala Ser Asn Leu Glu Ser Gly Val Pro Pro Arg Phe Ser Gly 
    50                  55                  60                  


Ser Gly Ser Gly Thr Asp Tyr Thr Leu Thr Ile Gly Gly Val Gln Ala 
65                  70                  75                  80  


Glu Asp Ala Ala Thr Tyr Tyr Cys Leu Gly Gly Tyr Ser Phe Ser Ser 
                85                  90                  95      


Asn Gly Leu Thr Phe Gly Ala Gly Thr Lys Val Glu Ile Lys 
            100                 105                 110 


<210>  44
<211>  330
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  4-H3 VL

<400>  44
gcttatgata tgacccagac tccaccctcc ctgtctgcat ctgtgggaga aactgtcagg       60

attaggtgcc tggccagtga ggacattgcc agtggtatat cctggtatca acagaagcca      120

gggaaacctc ctacactcct gatctatggt gcatccaatt tagaatctgg ggtcccacca      180

cggttcagtg gcagtggatc tgggacagat tacaccctca ccattggcgg cgtgcaggct      240

gaagatgctg ccacctacta ctgtctaggc ggttatagtt tcagtagtaa cggtttgact      300

tttggagctg gcaccaaggt ggagatcaaa                                       330


<210>  45
<211>  8
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  1-D5 CDR-H1

<400>  45

Gly Phe Ser Leu Asn Asn Tyr Ile 
1               5               


<210>  46
<211>  7
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  1-D5 CDR-H2

<400>  46

Ile Ser Thr Gly Gly Ser Thr 
1               5           


<210>  47
<211>  13
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  1-D5 CDR-H3

<400>  47

Ala Arg Gly Gly Ser Ser Ala Gly Ala Gly Phe Asn Ile 
1               5                   10              


<210>  48
<211>  25
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  1-D5 FR-H1

<400>  48

Gln Gln Gln Leu Val Glu Ser Gly Gly Arg Leu Val Thr Pro Gly Thr 
1               5                   10                  15      


Pro Leu Thr Leu Thr Cys Ala Val Ser 
            20                  25  


<210>  49
<211>  17
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  1-D5 FR-H2

<400>  49

Met Gly Trp Val Arg Gln Ala Pro Gly Lys Gly Leu Glu Tyr Ile Gly 
1               5                   10                  15      


Ile 
    


<210>  50
<211>  36
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  1-D5 FR-H3

<400>  50

Tyr Tyr Ala Ser Trp Ala Lys Gly Arg Phe Thr Ile Ser Arg Thr Ser 
1               5                   10                  15      


Thr Thr Met Asp Leu Lys Met Thr Ser Leu Thr Thr Glu Asp Thr Ala 
            20                  25                  30          


Thr Tyr Phe Cys 
        35      


<210>  51
<211>  11
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  1-D5 FR-H4

<400>  51

Trp Gly Pro Gly Thr Leu Val Thr Val Ser Ser 
1               5                   10      


<210>  52
<211>  117
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  1-D5 VH

<400>  52

Gln Gln Gln Leu Val Glu Ser Gly Gly Arg Leu Val Thr Pro Gly Thr 
1               5                   10                  15      


Pro Leu Thr Leu Thr Cys Ala Val Ser Gly Phe Ser Leu Asn Asn Tyr 
            20                  25                  30          


Ile Met Gly Trp Val Arg Gln Ala Pro Gly Lys Gly Leu Glu Tyr Ile 
        35                  40                  45              


Gly Ile Ile Ser Thr Gly Gly Ser Thr Tyr Tyr Ala Ser Trp Ala Lys 
    50                  55                  60                  


Gly Arg Phe Thr Ile Ser Arg Thr Ser Thr Thr Met Asp Leu Lys Met 
65                  70                  75                  80  


Thr Ser Leu Thr Thr Glu Asp Thr Ala Thr Tyr Phe Cys Ala Arg Gly 
                85                  90                  95      


Gly Ser Ser Ala Gly Ala Gly Phe Asn Ile Trp Gly Pro Gly Thr Leu 
            100                 105                 110         


Val Thr Val Ser Ser 
        115         


<210>  53
<211>  351
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  1-D5 VH

<400>  53
cagcagcagc tggtggagtc cgggggtcgc ctggtcacgc ctgggacacc cctgacacta       60

acctgcgcag tctctggatt ttccctcaat aactacatca tgggctgggt ccgccaggct      120

ccagggaagg ggctggaata catcggaatc attagtactg gtggtagcac atactacgcg      180

agctgggcaa aaggccgatt caccatctcc agaacctcga ccacgatgga tctgaaaatg      240

accagtctga caaccgagga cacggccacc tatttctgtg ccagaggggg tagtagtgct      300

ggtgcgggat ttaatatctg gggcccgggc accctggtca ccgtctcctc a               351


<210>  54
<211>  6
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  1-D5 CDR-L1

<400>  54

Gln Ser Ile Asn Ser Gly 
1               5       


<210>  55
<211>  3
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  1-D5 CDR-L2

<400>  55

Lys Ala Ser 
1           


<210>  56
<211>  12
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  1-D5 CDR-L3

<400>  56

Gln Ser Tyr His Tyr Ile Ser Ala Asn Gly Ala Thr 
1               5                   10          


<210>  57
<211>  26
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  1-D5 FR-L1

<400>  57

Asp Ile Val Met Thr Gln Thr Pro Ser Ser Val Ser Ala Ala Val Gly 
1               5                   10                  15      


Asp Thr Val Thr Ile Gln Cys Gln Ala Ser 
            20                  25      


<210>  58
<211>  17
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  1-D5 FR-L2

<400>  58

Leu Ala Trp Tyr Gln Gln Lys Pro Gly Gln Pro Pro Lys Arg Leu Ile 
1               5                   10                  15      


Tyr 
    


<210>  59
<211>  36
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  1-D5 FR-L3

<400>  59

Thr Leu Ala Ser Gly Val Pro Ser Arg Phe Arg Gly Ser Gly Ser Gly 
1               5                   10                  15      


Thr Asp Phe Thr Leu Thr Ile Ser Asp Leu Glu Cys Ala Asp Ala Ala 
            20                  25                  30          


Thr Tyr Tyr Cys 
        35      


<210>  60
<211>  10
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  1-D5 FR-L4

<400>  60

Phe Gly Gly Gly Thr Glu Val Val Val Glu 
1               5                   10  


<210>  61
<211>  110
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  1-D5 VL

<400>  61

Asp Ile Val Met Thr Gln Thr Pro Ser Ser Val Ser Ala Ala Val Gly 
1               5                   10                  15      


Asp Thr Val Thr Ile Gln Cys Gln Ala Ser Gln Ser Ile Asn Ser Gly 
            20                  25                  30          


Leu Ala Trp Tyr Gln Gln Lys Pro Gly Gln Pro Pro Lys Arg Leu Ile 
        35                  40                  45              


Tyr Lys Ala Ser Thr Leu Ala Ser Gly Val Pro Ser Arg Phe Arg Gly 
    50                  55                  60                  


Ser Gly Ser Gly Thr Asp Phe Thr Leu Thr Ile Ser Asp Leu Glu Cys 
65                  70                  75                  80  


Ala Asp Ala Ala Thr Tyr Tyr Cys Gln Ser Tyr His Tyr Ile Ser Ala 
                85                  90                  95      


Asn Gly Ala Thr Phe Gly Gly Gly Thr Glu Val Val Val Glu 
            100                 105                 110 


<210>  62
<211>  330
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  1-D5 VL

<400>  62
gatattgtta tgacccagac tccctcctcc gtgtctgcag ctgtgggaga cacagtcacc       60

atccagtgcc aggccagtca gagcattaat agtggtttgg cctggtatca gcagaaacca      120

gggcagcctc ccaagcgcct gatctacaag gcatccactc tggcatctgg ggtcccatcg      180

cggttcagag gcagtggatc tgggacagac ttcactctca ccatcagcga cctggagtgt      240

gccgatgctg ccacttacta ctgtcaaagc tatcattata ttagtgctaa tggtgctact      300

ttcggcggag ggaccgaggt ggtcgtcgaa                                       330


<210>  63
<211>  8
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  3-H9 CDR-H1

<400>  63

Gly Phe Ser Leu Ser Asn Tyr Asp 
1               5               


<210>  64
<211>  7
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  3-H9 CDR-H2

<400>  64

Ile His Ala Ile Gly Ile Thr 
1               5           


<210>  65
<211>  9
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  3-H9 CDR-H3

<400>  65

Ala Arg Gly Leu Val Asp Leu Asn Met 
1               5                   


<210>  66
<211>  25
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  3-H9 FR-H1

<400>  66

Ser Gln Ser Leu Glu Glu Ser Gly Gly Arg Leu Val Thr Pro Gly Thr 
1               5                   10                  15      


Pro Leu Thr Leu Thr Cys Ser Val Ser 
            20                  25  


<210>  67
<211>  17
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  3-H9 FR-H2

<400>  67

Met Ser Trp Val Arg Gln Ala Pro Gly Lys Gly Leu Glu Trp Ile Gly 
1               5                   10                  15      


Ser 
    


<210>  68
<211>  36
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  3-H9 FR-H3

<400>  68

Tyr Tyr Ala Asn Trp Ala Glu Gly Arg Phe Thr Ile Ser Lys Thr Ser 
1               5                   10                  15      


Thr Thr Val Asp Leu Lys Met Thr Ser Leu Thr Thr Glu Asp Thr Ala 
            20                  25                  30          


Thr Tyr Phe Cys 
        35      


<210>  69
<211>  11
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  3-H9 FR-H4

<400>  69

Trp Gly Pro Gly Thr Leu Val Thr Val Ser Ser 
1               5                   10      


<210>  70
<211>  112
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  3-H9 VH

<400>  70

Gln Ser Leu Glu Glu Ser Gly Gly Arg Leu Val Thr Pro Gly Thr Pro 
1               5                   10                  15      


Leu Thr Leu Thr Cys Ser Val Ser Gly Phe Ser Leu Ser Asn Tyr Asp 
            20                  25                  30          


Met Ser Trp Val Arg Gln Ala Pro Gly Lys Gly Leu Glu Trp Ile Gly 
        35                  40                  45              


Ser Ile His Ala Ile Gly Ile Thr Tyr Tyr Ala Asn Trp Ala Glu Gly 
    50                  55                  60                  


Arg Phe Thr Ile Ser Lys Thr Ser Thr Thr Val Asp Leu Lys Met Thr 
65                  70                  75                  80  


Ser Leu Thr Thr Glu Asp Thr Ala Thr Tyr Phe Cys Ala Arg Gly Leu 
                85                  90                  95      


Val Asp Leu Asn Met Trp Gly Pro Gly Thr Leu Val Thr Val Ser Ser 
            100                 105                 110         


<210>  71
<211>  336
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  3-H9 VH

<400>  71
cagtcgctgg aggagtccgg gggtcgcctg gtcacgcctg ggacaccctt gacactcacc       60

tgttcagtct ctggattctc cctcagcaac tacgacatga gctgggtccg ccaggctcca      120

gggaagggac tggaatggat cgggtccata catgctattg gtatcacata ctacgcgaac      180

tgggcggaag gccgattcac catctccaaa acctcgacca cggtggatct gaaaatgacc      240

agtctgacaa ccgaggacac ggccacctat ttctgtgcca gagggctggt agatttgaac      300

atgtggggcc cgggcaccct cgtcactgtc tcttca                                336


<210>  72
<211>  8
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  3-H9 CDR-L1

<400>  72

Gln Ser Val Tyr Ser Asn Asn Leu 
1               5               


<210>  73
<211>  3
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  3-H9 CDR-L2

<400>  73

Asp Ala Ser 
1           


<210>  74
<211>  12
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  3-H9 CDR-L3

<400>  74

Gln Gly Ser Tyr Tyr Ser Ser Gly Trp Tyr Asn Thr 
1               5                   10          


<210>  75
<211>  26
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  3-H9 FR-L1

<400>  75

Ala Ile Lys Met Thr Gln Thr Pro Ser Ser Val Ser Val Ala Val Gly 
1               5                   10                  15      


Gly Thr Val Thr Ile Asn Cys Gln Ser Ser 
            20                  25      


<210>  76
<211>  17
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  3-H9 FR-L2

<400>  76

Leu Ser Trp Tyr Gln Gln Lys Pro Gly Gln Pro Pro Lys Leu Leu Ile 
1               5                   10                  15      


Tyr 
    


<210>  77
<211>  36
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  3-H9 FR-L3

<400>  77

Thr Leu Glu Ser Gly Val Pro Ser Arg Phe Lys Gly Ser Gly Ser Gly 
1               5                   10                  15      


Thr Gln Phe Thr Leu Thr Ile Ser Gly Val Gln Cys Glu Asp Ala Ala 
            20                  25                  30          


Thr Tyr Tyr Cys 
        35      


<210>  78
<211>  10
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  3-H9 FR-L4

<400>  78

Phe Gly Gly Gly Thr Glu Val Val Val Glu 
1               5                   10  


<210>  79
<211>  112
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  3-H9 VL

<400>  79

Ala Ile Lys Met Thr Gln Thr Pro Ser Ser Val Ser Val Ala Val Gly 
1               5                   10                  15      


Gly Thr Val Thr Ile Asn Cys Gln Ser Ser Gln Ser Val Tyr Ser Asn 
            20                  25                  30          


Asn Leu Leu Ser Trp Tyr Gln Gln Lys Pro Gly Gln Pro Pro Lys Leu 
        35                  40                  45              


Leu Ile Tyr Asp Ala Ser Thr Leu Glu Ser Gly Val Pro Ser Arg Phe 
    50                  55                  60                  


Lys Gly Ser Gly Ser Gly Thr Gln Phe Thr Leu Thr Ile Ser Gly Val 
65                  70                  75                  80  


Gln Cys Glu Asp Ala Ala Thr Tyr Tyr Cys Gln Gly Ser Tyr Tyr Ser 
                85                  90                  95      


Ser Gly Trp Tyr Asn Thr Phe Gly Gly Gly Thr Glu Val Val Val Glu 
            100                 105                 110         


<210>  80
<211>  336
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  3-H9 VL

<400>  80
gctattaaaa tgacccagac tccatcgtcc gtgtctgtag ctgtgggagg cacagtcacc       60

atcaattgcc agtccagtca gagtgtttat agtaacaacc tcttatcttg gtaccagcag      120

aaaccagggc agcctcccaa gctcttgatc tacgatgcat ccactctgga atctggggtc      180

ccatcgcggt tcaaaggcag tggatctggg acacagttca ctctcaccat cagcggcgtg      240

cagtgtgagg atgctgccac ttactactgt caaggcagtt attatagtag tggttggtac      300

aatactttcg gcggagggac cgaggtggtc gtcgaa                                336


<210>  81
<211>  8
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  1-G5 CDR-H1

<400>  81

Gly Phe Ser Leu Ser Ser Tyr Asp 
1               5               


<210>  82
<211>  7
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  1-G5 CDR-H2

<400>  82

Ile His Ala Thr Gly Ile Thr 
1               5           


<210>  83
<211>  9
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  1-G5 CDR-H3

<400>  83

Ala Arg Gly Leu Val Asp Leu Asn Met 
1               5                   


<210>  84
<211>  25
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  1-G5 FR-H1

<400>  84

Ser Gln Ser Leu Glu Glu Ser Gly Gly Arg Leu Val Thr Pro Gly Thr 
1               5                   10                  15      


Pro Leu Thr Leu Thr Cys Ser Val Ser 
            20                  25  


<210>  85
<211>  17
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  1-G5 FR-H2

<400>  85

Met Thr Trp Val Arg Gln Ala Pro Gly Lys Gly Leu Glu Trp Ile Gly 
1               5                   10                  15      


Ser 
    


<210>  86
<211>  36
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  1-G5 FR-H3

<400>  86

Phe Tyr Ala Asn Trp Ala Lys Gly Arg Phe Thr Thr Ser Lys Thr Ser 
1               5                   10                  15      


Thr Thr Val Asp Leu Lys Met Thr Ser Leu Thr Thr Glu Asp Thr Ala 
            20                  25                  30          


Thr Tyr Phe Cys 
        35      


<210>  87
<211>  11
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  1-G5 FR-H4

<400>  87

Trp Gly Pro Gly Thr Leu Val Thr Val Ser Ser 
1               5                   10      


<210>  88
<211>  112
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  1-G5 VH

<400>  88

Gln Ser Leu Glu Glu Ser Gly Gly Arg Leu Val Thr Pro Gly Thr Pro 
1               5                   10                  15      


Leu Thr Leu Thr Cys Ser Val Ser Gly Phe Ser Leu Ser Ser Tyr Asp 
            20                  25                  30          


Met Thr Trp Val Arg Gln Ala Pro Gly Lys Gly Leu Glu Trp Ile Gly 
        35                  40                  45              


Ser Ile His Ala Thr Gly Ile Thr Phe Tyr Ala Asn Trp Ala Lys Gly 
    50                  55                  60                  


Arg Phe Thr Thr Ser Lys Thr Ser Thr Thr Val Asp Leu Lys Met Thr 
65                  70                  75                  80  


Ser Leu Thr Thr Glu Asp Thr Ala Thr Tyr Phe Cys Ala Arg Gly Leu 
                85                  90                  95      


Val Asp Leu Asn Met Trp Gly Pro Gly Thr Leu Val Thr Val Ser Ser 
            100                 105                 110         


<210>  89
<211>  336
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  1-G5 VH

<400>  89
cagtcgttgg aggagtccgg gggtcgcctg gtcacgcctg ggacaccctt gacactcacc       60

tgttcagtct ctggattctc cctcagcagc tacgacatga cctgggtccg ccaggctcca      120

gggaaggggc tggaatggat cgggtccata catgctactg gtatcacatt ctacgcgaac      180

tgggcgaaag gccgattcac cacctccaaa acctcgacca cggtggatct gaaaatgacc      240

agtctgacaa ccgaggacac ggccacctat ttctgtgcca gagggctggt agatttgaac      300

atgtggggcc cgggcaccct cgtcaccgtc tcttca                                336


<210>  90
<211>  8
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  1-G5 CDR-L1

<400>  90

Gln Ser Val Tyr Asn Asn Asn Tyr 
1               5               


<210>  91
<211>  3
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  1-G5 CDR-L2

<400>  91

Asp Ala Ser 
1           


<210>  92
<211>  12
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  1-G5 CDR-L3

<400>  92

Gln Gly Ser Tyr Tyr Ser Gly Gly Trp Asp Thr Ala 
1               5                   10          


<210>  93
<211>  26
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  1-G5 FR-L1

<400>  93

Asp Pro Val Met Thr Gln Thr Ala Ser Ser Val Ser Ala Ala Val Gly 
1               5                   10                  15      


Gly Thr Val Thr Ile Asn Cys Gln Ala Ser 
            20                  25      


<210>  94
<211>  17
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  1-G5 FR-L2

<400>  94

Leu Ser Trp Tyr Gln Gln Lys Pro Gly Gln Pro Pro Lys Leu Leu Ile 
1               5                   10                  15      


Tyr 
    


<210>  95
<211>  36
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  1-G5 FR-L3

<400>  95

Thr Leu Ala Ser Gly Val Pro Ser Arg Phe Ser Gly Asn Gly Ser Gly 
1               5                   10                  15      


Thr Gln Phe Thr Leu Thr Ile Ser Gly Val Gln Cys Asp Asp Ala Ala 
            20                  25                  30          


Thr Tyr Tyr Cys 
        35      


<210>  96
<211>  10
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  1-G5 FR-L4

<400>  96

Phe Gly Gly Gly Thr Lys Val Val Val Lys 
1               5                   10  


<210>  97
<211>  112
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  1-G5 VL

<400>  97

Asp Pro Val Met Thr Gln Thr Ala Ser Ser Val Ser Ala Ala Val Gly 
1               5                   10                  15      


Gly Thr Val Thr Ile Asn Cys Gln Ala Ser Gln Ser Val Tyr Asn Asn 
            20                  25                  30          


Asn Tyr Leu Ser Trp Tyr Gln Gln Lys Pro Gly Gln Pro Pro Lys Leu 
        35                  40                  45              


Leu Ile Tyr Asp Ala Ser Thr Leu Ala Ser Gly Val Pro Ser Arg Phe 
    50                  55                  60                  


Ser Gly Asn Gly Ser Gly Thr Gln Phe Thr Leu Thr Ile Ser Gly Val 
65                  70                  75                  80  


Gln Cys Asp Asp Ala Ala Thr Tyr Tyr Cys Gln Gly Ser Tyr Tyr Ser 
                85                  90                  95      


Gly Gly Trp Asp Thr Ala Phe Gly Gly Gly Thr Lys Val Val Val Lys 
            100                 105                 110         


<210>  98
<211>  336
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  1-G5 VL

<400>  98
gatcccgtga tgacccagac tgcgtcctcc gtgtctgcag ctgtgggagg cacagtcacc       60

atcaattgcc aggccagtca gagtgtttat aataacaact acttatcctg gtatcagcag      120

aaaccagggc agcctcccaa gctcttgatc tacgatgcat ccactctggc atctggggtc      180

ccatcccggt tcagcggcaa tggatctggg acacagttca ctctcaccat cagcggcgta      240

cagtgtgacg atgctgccac ttactactgt caaggcagtt attatagtgg tggttgggac      300

actgctttcg gcggagggac caaggtggtc gtcaaa                                336


<210>  99
<211>  8
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  4-H9 CDR-H1

<400>  99

Gly Phe Ser Leu Asn Ser Phe Ala 
1               5               


<210>  100
<211>  7
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  4-H9 CDR-H2

<400>  100

Ile Thr Val Asp Gly His Thr 
1               5           


<210>  101
<211>  17
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  4-H9 CDR-H3

<400>  101

Ala Arg Glu Asp Ala Gly Asp Ala Gly Tyr Ile Tyr Ala Thr Tyr Asn 
1               5                   10                  15      


Ile 
    


<210>  102
<211>  25
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  4-H9 FR-H1

<400>  102

Ser Gln Ser Val Glu Glu Ser Gly Gly Arg Leu Val Thr Pro Gly Thr 
1               5                   10                  15      


Pro Leu Thr Leu Thr Cys Thr Ala Ser 
            20                  25  


<210>  103
<211>  17
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  4-H9 FR-H2

<400>  103

Met Ser Trp Val Arg Gln Ala Pro Gly Lys Gly Leu Glu Trp Ile Gly 
1               5                   10                  15      


Ile 
    


<210>  104
<211>  36
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  4-H9 FR-H3

<400>  104

Tyr Tyr Ala Ser Trp Ala Lys Gly Arg Phe Thr Ile Ser Lys Ala Ser 
1               5                   10                  15      


Thr Thr Val Asp Leu Lys Ile Thr Ser Pro Thr Thr Glu Asp Thr Ala 
            20                  25                  30          


Thr Tyr Phe Cys 
        35      


<210>  105
<211>  11
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  4-H9 FR-H4

<400>  105

Trp Gly Pro Gly Thr Leu Val Thr Val Ser Ser 
1               5                   10      


<210>  106
<211>  120
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  4-H9 VH

<400>  106

Gln Ser Val Glu Glu Ser Gly Gly Arg Leu Val Thr Pro Gly Thr Pro 
1               5                   10                  15      


Leu Thr Leu Thr Cys Thr Ala Ser Gly Phe Ser Leu Asn Ser Phe Ala 
            20                  25                  30          


Met Ser Trp Val Arg Gln Ala Pro Gly Lys Gly Leu Glu Trp Ile Gly 
        35                  40                  45              


Ile Ile Thr Val Asp Gly His Thr Tyr Tyr Ala Ser Trp Ala Lys Gly 
    50                  55                  60                  


Arg Phe Thr Ile Ser Lys Ala Ser Thr Thr Val Asp Leu Lys Ile Thr 
65                  70                  75                  80  


Ser Pro Thr Thr Glu Asp Thr Ala Thr Tyr Phe Cys Ala Arg Glu Asp 
                85                  90                  95      


Ala Gly Asp Ala Gly Tyr Ile Tyr Ala Thr Tyr Asn Ile Trp Gly Pro 
            100                 105                 110         


Gly Thr Leu Val Thr Val Ser Ser 
        115                 120 


<210>  107
<211>  360
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  4-H9 VH

<400>  107
caatcggtgg aggagtccgg gggtcgcctg gtcacgcctg ggacacccct gacactcacc       60

tgcacagcct ctggattctc cctcaatagc tttgcgatga gctgggtccg ccaggctcca      120

gggaaggggc tggaatggat cggaatcatt actgttgatg gtcacacata ctacgcgagc      180

tgggcgaaag gccgattcac catctccaaa gcctcgacca cggtggatct gaaaatcacc      240

agtccgacaa ccgaggacac ggccacctat ttctgtgcca gagaggatgc tggtgatgct      300

ggttatattt atgctaccta taacatctgg ggcccaggga ccctcgtcac cgtctcttca      360


<210>  108
<211>  6
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  4-H9 CDR-L1

<400>  108

Glu Asp Ile Gly Tyr Gly 
1               5       


<210>  109
<211>  3
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  4-H9 CDR-L2

<400>  109

Gly Ala Asn 
1           


<210>  110
<211>  9
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  4-H9 CDR-L3

<400>  110

Gln Gln Gly Tyr Ser Thr Pro Pro Thr 
1               5                   


<210>  111
<211>  26
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  4-H9 FR-L1

<400>  111

Ala Ile Glu Met Thr Gln Thr Pro Ser Ser Leu Ala Ala Ser Val Gly 
1               5                   10                  15      


Asp Thr Val Thr Ile Thr Cys Lys Ala Ser 
            20                  25      


<210>  112
<211>  17
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  4-H9 FR-L2

<400>  112

Leu Ala Trp Tyr Gln Gln Lys Leu Gly Ile Ala Pro Lys Leu Leu Ile 
1               5                   10                  15      


Tyr 
    


<210>  113
<211>  36
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  4-H9 FR-L3

<400>  113

Thr Leu Glu Ser Gly Val Pro Ser Arg Phe Ser Gly Ser Gly Ser Glu 
1               5                   10                  15      


Thr Asp Tyr Thr Leu Thr Ile Ser Ser Val Gln Ala Glu Asp Ala Gly 
            20                  25                  30          


Ile Tyr Tyr Cys 
        35      


<210>  114
<211>  10
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  4-H9 FR-L4

<400>  114

Phe Gly Ala Gly Thr Met Val Glu Ile Gln 
1               5                   10  


<210>  115
<211>  107
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  4-H9 VL

<400>  115

Ala Ile Glu Met Thr Gln Thr Pro Ser Ser Leu Ala Ala Ser Val Gly 
1               5                   10                  15      


Asp Thr Val Thr Ile Thr Cys Lys Ala Ser Glu Asp Ile Gly Tyr Gly 
            20                  25                  30          


Leu Ala Trp Tyr Gln Gln Lys Leu Gly Ile Ala Pro Lys Leu Leu Ile 
        35                  40                  45              


Tyr Gly Ala Asn Thr Leu Glu Ser Gly Val Pro Ser Arg Phe Ser Gly 
    50                  55                  60                  


Ser Gly Ser Glu Thr Asp Tyr Thr Leu Thr Ile Ser Ser Val Gln Ala 
65                  70                  75                  80  


Glu Asp Ala Gly Ile Tyr Tyr Cys Gln Gln Gly Tyr Ser Thr Pro Pro 
                85                  90                  95      


Thr Phe Gly Ala Gly Thr Met Val Glu Ile Gln 
            100                 105         


<210>  116
<211>  321
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  4-H9 VL

<400>  116
gcgattgaaa tgacccagac tccatcctcc ctggctgcat ctgtgggaga cacagtcacc       60

atcacttgta aggccagtga ggacattggt tatgggttag cctggtatca gcagaaactg      120

gggatagctc ctaagctcct gatctatggg gcaaacactt tagaatctgg ggtcccatcg      180

aggttcagtg gcagcggatc agagaccgat tacaccctca ccatcagcag cgtgcaggct      240

gaagatgcag gaatttatta ctgtcagcaa ggatatagta cccctcctac tttcggtgcg      300

gggaccatgg tggagatcca a                                                321


<210>  117
<211>  8
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  4-B12 CDR-H1

<400>  117

Gly Phe Ser Leu Asn Ser Phe Ala 
1               5               


<210>  118
<211>  7
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  4-B12 CDR-H2

<400>  118

Ile Thr Val Asp Gly His Thr 
1               5           


<210>  119
<211>  17
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  4-B12 CDR-H3

<400>  119

Ala Arg Glu Asp Ala Gly Asp Ala Gly Tyr Ile Tyr Ala Thr Tyr Asn 
1               5                   10                  15      


Ile 
    


<210>  120
<211>  25
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  4-B12 FR-H1

<400>  120

Ser Gln Ser Val Lys Glu Ser Glu Gly Arg Leu Val Thr Pro Gly Thr 
1               5                   10                  15      


Pro Leu Thr Leu Thr Cys Thr Val Ser 
            20                  25  


<210>  121
<211>  17
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  4-B12 FR-H2

<400>  121

Met Ser Trp Val Arg Gln Ala Pro Gly Lys Gly Leu Glu Trp Ile Gly 
1               5                   10                  15      


Ile 
    


<210>  122
<211>  36
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  4-B12 FR-H3

<400>  122

Tyr Tyr Ala Asn Trp Ala Lys Asp Arg Phe Thr Ile Ser Lys Ala Ser 
1               5                   10                  15      


Thr Thr Val Asp Leu Lys Ile Thr Ser Pro Thr Thr Glu Asp Thr Ala 
            20                  25                  30          


Thr Tyr Phe Cys 
        35      


<210>  123
<211>  11
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  4-B12 FR-H4

<400>  123

Trp Gly Pro Gly Thr Leu Val Thr Val Ser Ser 
1               5                   10      


<210>  124
<211>  120
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  4-B12 VH

<400>  124

Gln Ser Val Lys Glu Ser Glu Gly Arg Leu Val Thr Pro Gly Thr Pro 
1               5                   10                  15      


Leu Thr Leu Thr Cys Thr Val Ser Gly Phe Ser Leu Asn Ser Phe Ala 
            20                  25                  30          


Met Ser Trp Val Arg Gln Ala Pro Gly Lys Gly Leu Glu Trp Ile Gly 
        35                  40                  45              


Ile Ile Thr Val Asp Gly His Thr Tyr Tyr Ala Asn Trp Ala Lys Asp 
    50                  55                  60                  


Arg Phe Thr Ile Ser Lys Ala Ser Thr Thr Val Asp Leu Lys Ile Thr 
65                  70                  75                  80  


Ser Pro Thr Thr Glu Asp Thr Ala Thr Tyr Phe Cys Ala Arg Glu Asp 
                85                  90                  95      


Ala Gly Asp Ala Gly Tyr Ile Tyr Ala Thr Tyr Asn Ile Trp Gly Pro 
            100                 105                 110         


Gly Thr Leu Val Thr Val Ser Ser 
        115                 120 


<210>  125
<211>  360
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  4-B12 VH

<400>  125
cagtcggtga aggagtccga gggtcgcctg gtcacgcctg ggacacccct gacactcacc       60

tgcacagtct ctggattctc cctcaatagc tttgcgatga gctgggtccg ccaggctcca      120

gggaaggggc tggaatggat cggaatcata actgttgatg gtcacacata ctacgcgaac      180

tgggcgaaag accgattcac catctccaaa gcctcgacca cggtggatct gaaaatcacc      240

agtccgacaa ccgaggacac ggccacctat ttctgtgcca gagaggatgc tggtgatgct      300

ggttatattt atgctaccta taacatctgg ggcccgggca ccctggtcac cgtctcctca      360


<210>  126
<211>  6
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  4-B12 CDR-L1

<400>  126

Glu Asp Ile Gly Tyr Gly 
1               5       


<210>  127
<211>  3
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  4-B12 CDR-L2

<400>  127

Gly Ala Asn 
1           


<210>  128
<211>  9
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  4-B12 CDR-L3

<400>  128

Gln Gln Gly Tyr Ser Thr Pro Pro Thr 
1               5                   


<210>  129
<211>  26
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  4-B12 FR-L1

<400>  129

Asp Pro Val Leu Thr Gln Thr Ala Ser Ser Leu Ala Ala Ser Val Gly 
1               5                   10                  15      


Asp Thr Val Thr Ile Thr Cys Lys Ala Ser 
            20                  25      


<210>  130
<211>  17
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  4-B12 FR-L2

<400>  130

Leu Ala Trp Tyr Gln Gln Lys Pro Gly Gln Pro Pro Lys Leu Leu Ile 
1               5                   10                  15      


Tyr 
    


<210>  131
<211>  36
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  4-B12 FR-L3

<400>  131

Thr Leu Glu Ser Gly Val Pro Ser Arg Phe Thr Gly Ser Gly Ser Glu 
1               5                   10                  15      


Thr Asp Tyr Thr Leu Thr Ile Ser Ser Val Gln Ala Glu Asp Ala Gly 
            20                  25                  30          


Ile Tyr Tyr Cys 
        35      


<210>  132
<211>  10
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  4-B12 FR-L4

<400>  132

Phe Gly Ala Gly Thr Lys Val Glu Ile Lys 
1               5                   10  


<210>  133
<211>  107
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  4-B12 VL

<400>  133

Asp Pro Val Leu Thr Gln Thr Ala Ser Ser Leu Ala Ala Ser Val Gly 
1               5                   10                  15      


Asp Thr Val Thr Ile Thr Cys Lys Ala Ser Glu Asp Ile Gly Tyr Gly 
            20                  25                  30          


Leu Ala Trp Tyr Gln Gln Lys Pro Gly Gln Pro Pro Lys Leu Leu Ile 
        35                  40                  45              


Tyr Gly Ala Asn Thr Leu Glu Ser Gly Val Pro Ser Arg Phe Thr Gly 
    50                  55                  60                  


Ser Gly Ser Glu Thr Asp Tyr Thr Leu Thr Ile Ser Ser Val Gln Ala 
65                  70                  75                  80  


Glu Asp Ala Gly Ile Tyr Tyr Cys Gln Gln Gly Tyr Ser Thr Pro Pro 
                85                  90                  95      


Thr Phe Gly Ala Gly Thr Lys Val Glu Ile Lys 
            100                 105         


<210>  134
<211>  321
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  4-B12 VL

<400>  134
gatcctgtgc tgacccagac tgcgtcctcc ctggctgcat ctgtgggaga cacagtcacc       60

atcacttgta aggccagtga ggacattggt tatgggttag cctggtatca gcagaaacca      120

gggcagcctc ccaagctcct gatctatggg gcaaacactt tagaatctgg ggtcccatcg      180

aggttcactg gcagcggatc agagaccgat tacaccctca ccatcagcag cgtgcaggct      240

gaagatgcag gaatttatta ctgtcagcaa ggatatagta cccctcctac tttcggtgcg      300

ggcaccaagg tagaaatcaa a                                                321


<210>  135
<211>  8
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  4-C6 CDR-H1

<400>  135

Gly Phe Ser Leu Asn Thr Tyr Val 
1               5               


<210>  136
<211>  7
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  4-C6 CDR-H2

<400>  136

Ile Asn Gly Asp Ser Asn Thr 
1               5           


<210>  137
<211>  17
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  4-C6 CDR-H3

<400>  137

Ala Arg Glu Asp Ala Ala Asp Ala Gly Tyr Val Tyr Ala Thr Tyr Asn 
1               5                   10                  15      


Ile 
    


<210>  138
<211>  25
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  4-C6 FR-H1

<400>  138

Ser Gln Ser Leu Glu Glu Ser Gly Gly Arg Leu Val Thr Pro Gly Thr 
1               5                   10                  15      


Pro Leu Thr Leu Thr Cys Thr Ala Ser 
            20                  25  


<210>  139
<211>  17
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  4-C6 FR-H2

<400>  139

Met Thr Trp Val Arg Gln Ala Pro Gly Lys Gly Leu Glu Trp Ile Gly 
1               5                   10                  15      


Phe 
    


<210>  140
<211>  36
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  4-C6 FR-H3

<400>  140

Tyr Tyr Ala Asn Trp Ala Lys Gly Arg Phe Thr Ile Ser Lys Thr Ser 
1               5                   10                  15      


Thr Thr Val Asp Leu Lys Ile Thr Ser Pro Thr Thr Glu Asp Thr Ala 
            20                  25                  30          


Thr Tyr Phe Cys 
        35      


<210>  141
<211>  11
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  4-C6 FR-H4

<400>  141

Trp Gly Thr Gly Thr Leu Val Thr Ile Ser Ser 
1               5                   10      


<210>  142
<211>  120
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  4-C6 VH

<400>  142

Gln Ser Leu Glu Glu Ser Gly Gly Arg Leu Val Thr Pro Gly Thr Pro 
1               5                   10                  15      


Leu Thr Leu Thr Cys Thr Ala Ser Gly Phe Ser Leu Asn Thr Tyr Val 
            20                  25                  30          


Met Thr Trp Val Arg Gln Ala Pro Gly Lys Gly Leu Glu Trp Ile Gly 
        35                  40                  45              


Phe Ile Asn Gly Asp Ser Asn Thr Tyr Tyr Ala Asn Trp Ala Lys Gly 
    50                  55                  60                  


Arg Phe Thr Ile Ser Lys Thr Ser Thr Thr Val Asp Leu Lys Ile Thr 
65                  70                  75                  80  


Ser Pro Thr Thr Glu Asp Thr Ala Thr Tyr Phe Cys Ala Arg Glu Asp 
                85                  90                  95      


Ala Ala Asp Ala Gly Tyr Val Tyr Ala Thr Tyr Asn Ile Trp Gly Thr 
            100                 105                 110         


Gly Thr Leu Val Thr Ile Ser Ser 
        115                 120 


<210>  143
<211>  360
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  4-C6 VH

<400>  143
cagtcgctgg aggagtccgg gggtcgcctg gtcacgcctg ggacacccct gacactcacc       60

tgcacagcct ctggattctc cctcaatacc tatgtaatga cctgggtccg ccaggctcca      120

gggaaggggc tggaatggat cggattcatt aatggtgata gtaacacata ctacgcgaac      180

tgggcgaaag gccgattcac catctccaaa acctcgacca cggtggatct gaaaatcacc      240

agtccgacaa ccgaggacac ggccacctat ttctgtgcca gagaggatgc tgctgatgct      300

ggttatgttt atgctaccta taacatctgg ggcacaggca ccctggtcac catctcttca      360


<210>  144
<211>  6
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  4-C6 CDR-L1

<400>  144

Glu Asp Ile Gly Tyr Gly 
1               5       


<210>  145
<211>  3
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  4-C6 CDR-L2

<400>  145

Gly Ala Asn 
1           


<210>  146
<211>  9
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  4-C6 CDR-L3

<400>  146

Gln Gln Gly Tyr Ser Thr Pro Pro Thr 
1               5                   


<210>  147
<211>  26
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  4-C6 FR-L1

<400>  147

Ala Tyr Asp Met Thr Gln Thr Pro Ser Ser Leu Ala Ala Ser Val Gly 
1               5                   10                  15      


Asp Thr Val Thr Ile Thr Cys Lys Ala Ser 
            20                  25      


<210>  148
<211>  17
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  4-C6 FR-L2

<400>  148

Leu Asn Trp Tyr Gln Gln Lys Leu Gly Ile Ala Pro Lys Leu Leu Ile 
1               5                   10                  15      


Tyr 
    


<210>  149
<211>  36
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  4-C6 FR-L3

<400>  149

Thr Leu Glu Ser Gly Val Pro Ser Arg Phe Ser Gly Ser Gly Ser Glu 
1               5                   10                  15      


Thr Asp Tyr Thr Leu Thr Ile Ser Ser Val Gln Ala Glu Asp Ala Gly 
            20                  25                  30          


Ile Tyr Tyr Cys 
        35      


<210>  150
<211>  10
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  4-C6 FR-L4

<400>  150

Phe Gly Ala Gly Thr Met Val Glu Ile Lys 
1               5                   10  


<210>  151
<211>  107
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  4-C6 VL

<400>  151

Ala Tyr Asp Met Thr Gln Thr Pro Ser Ser Leu Ala Ala Ser Val Gly 
1               5                   10                  15      


Asp Thr Val Thr Ile Thr Cys Lys Ala Ser Glu Asp Ile Gly Tyr Gly 
            20                  25                  30          


Leu Asn Trp Tyr Gln Gln Lys Leu Gly Ile Ala Pro Lys Leu Leu Ile 
        35                  40                  45              


Tyr Gly Ala Asn Thr Leu Glu Ser Gly Val Pro Ser Arg Phe Ser Gly 
    50                  55                  60                  


Ser Gly Ser Glu Thr Asp Tyr Thr Leu Thr Ile Ser Ser Val Gln Ala 
65                  70                  75                  80  


Glu Asp Ala Gly Ile Tyr Tyr Cys Gln Gln Gly Tyr Ser Thr Pro Pro 
                85                  90                  95      


Thr Phe Gly Ala Gly Thr Met Val Glu Ile Lys 
            100                 105         


<210>  152
<211>  321
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  4-C6 VL

<400>  152
gcatatgata tgacccagac tccatcctcc ctggctgcat ctgtgggaga cacagtcacc       60

atcacttgta aggccagtga ggacattggt tatgggttga actggtatca gcagaaacta      120

gggatagctc ctaagctcct catctatggg gcaaacactt tagaatccgg ggtcccatcg      180

aggttcagtg gcagcggatc agagaccgat tacaccctca ccatcagcag cgtgcaggct      240

gaagatgcag gaatttatta ctgtcagcaa ggatatagta cccctcctac tttcggtgcg      300

gggaccatgg tggagatcaa a                                                321


<210>  153
<211>  177
<212>  PRT
<213>  Homo sapiens

<400>  153

Asp Leu Val Phe Leu Leu Asp Gly Ser Ser Arg Leu Ser Glu Ala Glu 
1               5                   10                  15      


Phe Glu Val Leu Lys Ala Phe Val Val Asp Met Met Glu Arg Leu Arg 
            20                  25                  30          


Ile Ser Gln Lys Trp Val Arg Val Ala Val Val Glu Tyr His Asp Gly 
        35                  40                  45              


Ser His Ala Tyr Ile Gly Leu Lys Asp Arg Lys Arg Pro Ser Glu Leu 
    50                  55                  60                  


Arg Arg Ile Ala Ser Gln Val Lys Tyr Ala Gly Ser Gln Val Ala Ser 
65                  70                  75                  80  


Thr Ser Glu Val Leu Lys Tyr Thr Leu Phe Gln Ile Phe Ser Lys Ile 
                85                  90                  95      


Asp Arg Pro Glu Ala Ser Arg Ile Thr Leu Leu Leu Met Ala Ser Gln 
            100                 105                 110         


Glu Pro Gln Arg Met Ser Arg Asn Phe Val Arg Tyr Val Gln Gly Leu 
        115                 120                 125             


Lys Lys Lys Lys Val Ile Val Ile Pro Val Gly Ile Gly Pro His Ala 
    130                 135                 140                 


Asn Leu Lys Gln Ile Arg Leu Ile Glu Lys Gln Ala Pro Glu Asn Lys 
145                 150                 155                 160 


Ala Phe Val Leu Ser Ser Val Asp Glu Leu Glu Gln Gln Arg Asp Glu 
                165                 170                 175     


Ile 
    


<210>  154
<211>  172
<212>  PRT
<213>  Homo sapiens

<400>  154

Asp Val Ala Phe Val Leu Glu Gly Ser Asp Lys Ile Gly Glu Ala Asp 
1               5                   10                  15      


Phe Asn Arg Ser Lys Glu Phe Met Glu Glu Val Ile Gln Arg Met Asp 
            20                  25                  30          


Val Gly Gln Asp Ser Ile His Val Thr Val Leu Gln Tyr Ser Tyr Met 
        35                  40                  45              


Val Thr Val Glu Tyr Pro Phe Ser Glu Ala Gln Ser Lys Gly Asp Ile 
    50                  55                  60                  


Leu Gln Arg Val Arg Glu Ile Arg Tyr Gln Gly Gly Asn Arg Thr Asn 
65                  70                  75                  80  


Thr Gly Leu Ala Leu Arg Tyr Leu Ser Asp His Ser Phe Leu Val Ser 
                85                  90                  95      


Gln Gly Asp Arg Glu Gln Ala Pro Asn Leu Val Tyr Met Val Thr Gly 
            100                 105                 110         


Asn Pro Ala Ser Asp Glu Ile Lys Arg Leu Pro Gly Asp Ile Gln Val 
        115                 120                 125             


Val Pro Ile Gly Val Gly Pro Asn Ala Asn Val Gln Glu Leu Glu Arg 
    130                 135                 140                 


Ile Gly Trp Pro Asn Ala Pro Ile Leu Ile Gln Asp Phe Glu Thr Leu 
145                 150                 155                 160 


Pro Arg Glu Ala Pro Asp Leu Val Gln Arg Cys Cys 
                165                 170         


<210>  155
<211>  181
<212>  PRT
<213>  Homo sapiens

<400>  155

Asp Val Ile Leu Leu Leu Asp Gly Ser Ser Ser Phe Pro Ala Ser Tyr 
1               5                   10                  15      


Phe Asp Glu Met Lys Ser Phe Ala Lys Ala Phe Ile Ser Lys Ala Asn 
            20                  25                  30          


Ile Gly Pro Arg Leu Thr Gln Val Ser Val Leu Gln Tyr Gly Ser Ile 
        35                  40                  45              


Thr Thr Ile Asp Val Pro Trp Asn Val Val Pro Glu Lys Ala His Leu 
    50                  55                  60                  


Leu Ser Leu Val Asp Val Met Gln Arg Glu Gly Gly Pro Ser Gln Ile 
65                  70                  75                  80  


Gly Asp Ala Leu Gly Phe Ala Val Arg Tyr Leu Thr Ser Glu Met His 
                85                  90                  95      


Gly Ala Arg Pro Gly Ala Ser Lys Ala Val Val Ile Leu Val Thr Asp 
            100                 105                 110         


Val Ser Val Asp Ser Val Asp Ala Ala Ala Asp Ala Ala Arg Ser Asn 
        115                 120                 125             


Arg Val Thr Val Phe Pro Ile Gly Ile Gly Asp Arg Tyr Asp Ala Ala 
    130                 135                 140                 


Gln Leu Arg Ile Leu Ala Gly Pro Ala Gly Asp Ser Asn Val Val Lys 
145                 150                 155                 160 


Leu Gln Arg Ile Glu Asp Leu Pro Thr Met Val Thr Leu Gly Asn Ser 
                165                 170                 175     


Phe Leu His Lys Leu 
            180     


<210>  156
<211>  113
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  1-A2 VH

<400>  156

Ser Gln Ser Val Glu Glu Ser Gly Gly Arg Leu Val Pro Pro Gly Thr 
1               5                   10                  15      


Pro Leu Thr Leu Thr Cys Thr Val Ser Gly Ile Asp Leu Thr Ser Asn 
            20                  25                  30          


Ala Met Asn Trp Val Arg Gln Ala Pro Gly Lys Gly Leu Glu Trp Ile 
        35                  40                  45              


Gly Gly Ile Tyr Gly His Asp Thr Ser Tyr Tyr Ala Ala Trp Ala Lys 
    50                  55                  60                  


Gly Arg Phe Thr Ile Ser Arg Thr Ser Thr Thr Val Asp Leu Lys Met 
65                  70                  75                  80  


Thr Arg Pro Thr Thr Asp Asp Thr Ala Thr Tyr Phe Cys Ala Arg Gly 
                85                  90                  95      


Phe Ile Tyr Phe Asp Ile Trp Gly Thr Gly Thr Leu Val Thr Ile Ser 
            100                 105                 110         


Ser 
    


<210>  157
<211>  330
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  mAb HC

<400>  157

Ala Ser Thr Lys Gly Pro Ser Val Phe Pro Leu Ala Pro Ser Ser Lys 
1               5                   10                  15      


Ser Thr Ser Gly Gly Thr Ala Ala Leu Gly Cys Leu Val Lys Asp Tyr 
            20                  25                  30          


Phe Pro Glu Pro Val Thr Val Ser Trp Asn Ser Gly Ala Leu Thr Ser 
        35                  40                  45              


Gly Val His Thr Phe Pro Ala Val Leu Gln Ser Ser Gly Leu Tyr Ser 
    50                  55                  60                  


Leu Ser Ser Val Val Thr Val Pro Ser Ser Ser Leu Gly Thr Gln Thr 
65                  70                  75                  80  


Tyr Ile Cys Asn Val Asn His Lys Pro Ser Asn Thr Lys Val Asp Lys 
                85                  90                  95      


Lys Val Glu Pro Lys Ser Cys Asp Lys Thr His Thr Cys Pro Pro Cys 
            100                 105                 110         


Pro Ala Pro Glu Leu Leu Gly Gly Pro Ser Val Phe Leu Phe Pro Pro 
        115                 120                 125             


Lys Pro Lys Asp Thr Leu Met Ile Ser Arg Thr Pro Glu Val Thr Cys 
    130                 135                 140                 


Val Val Val Asp Val Ser His Glu Asp Pro Glu Val Lys Phe Asn Trp 
145                 150                 155                 160 


Tyr Val Asp Gly Val Glu Val His Asn Ala Lys Thr Lys Pro Arg Glu 
                165                 170                 175     


Glu Gln Tyr Asn Ser Thr Tyr Arg Val Val Ser Val Leu Thr Val Leu 
            180                 185                 190         


His Gln Asp Trp Leu Asn Gly Lys Glu Tyr Lys Cys Lys Val Ser Asn 
        195                 200                 205             


Lys Ala Leu Pro Ala Pro Ile Glu Lys Thr Ile Ser Lys Ala Lys Gly 
    210                 215                 220                 


Gln Pro Arg Glu Pro Gln Val Tyr Thr Leu Pro Pro Ser Arg Asp Glu 
225                 230                 235                 240 


Leu Thr Lys Asn Gln Val Ser Leu Thr Cys Leu Val Lys Gly Phe Tyr 
                245                 250                 255     


Pro Ser Asp Ile Ala Val Glu Trp Glu Ser Asn Gly Gln Pro Glu Asn 
            260                 265                 270         


Asn Tyr Lys Thr Thr Pro Pro Val Leu Asp Ser Asp Gly Ser Phe Phe 
        275                 280                 285             


Leu Tyr Ser Lys Leu Thr Val Asp Lys Ser Arg Trp Gln Gln Gly Asn 
    290                 295                 300                 


Val Phe Ser Cys Ser Val Met His Glu Ala Leu His Asn His Tyr Thr 
305                 310                 315                 320 


Gln Lys Ser Leu Ser Leu Ser Pro Gly Lys 
                325                 330 


<210>  158
<211>  106
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  mAb LC

<400>  158

Thr Val Ala Ala Pro Ser Val Phe Ile Phe Pro Pro Ser Asp Glu Gln 
1               5                   10                  15      


Leu Lys Ser Gly Thr Ala Ser Val Val Cys Leu Leu Asn Asn Phe Tyr 
            20                  25                  30          


Pro Arg Glu Ala Lys Val Gln Trp Lys Val Asp Asn Ala Leu Gln Ser 
        35                  40                  45              


Gly Asn Ser Gln Glu Ser Val Thr Glu Gln Asp Ser Lys Asp Ser Thr 
    50                  55                  60                  


Tyr Ser Leu Ser Ser Thr Leu Thr Leu Ser Lys Ala Asp Tyr Glu Lys 
65                  70                  75                  80  


His Lys Val Tyr Ala Cys Glu Val Thr His Gln Gly Leu Ser Ser Pro 
                85                  90                  95      


Val Thr Lys Ser Phe Asn Arg Gly Glu Cys 
            100                 105     


<210>  159
<211>  113
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  4-H3 VH

<400>  159

Ser Gln Ser Leu Glu Glu Ser Gly Gly Arg Leu Val Pro Pro Gly Thr 
1               5                   10                  15      


Pro Leu Thr Leu Thr Cys Thr Val Ser Gly Ile Asp Leu Thr Ser Asn 
            20                  25                  30          


Ala Met Asn Trp Val Arg Gln Ala Pro Gly Lys Gly Leu Glu Trp Ile 
        35                  40                  45              


Gly Gly Ile Tyr Gly His Asp Thr Ser Tyr Tyr Ala Ala Trp Ala Lys 
    50                  55                  60                  


Gly Arg Phe Thr Ile Ser Arg Thr Ser Thr Thr Val Asp Leu Lys Met 
65                  70                  75                  80  


Thr Arg Pro Thr Thr Asp Asp Thr Ala Thr Tyr Phe Cys Ala Arg Gly 
                85                  90                  95      


Phe Ile Tyr Phe Asp Ile Trp Gly Thr Gly Thr Leu Val Thr Ile Ser 
            100                 105                 110         


Ser 
    


<210>  160
<211>  113
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  3-H9 VH

<400>  160

Ser Gln Ser Leu Glu Glu Ser Gly Gly Arg Leu Val Thr Pro Gly Thr 
1               5                   10                  15      


Pro Leu Thr Leu Thr Cys Ser Val Ser Gly Phe Ser Leu Ser Asn Tyr 
            20                  25                  30          


Asp Met Ser Trp Val Arg Gln Ala Pro Gly Lys Gly Leu Glu Trp Ile 
        35                  40                  45              


Gly Ser Ile His Ala Ile Gly Ile Thr Tyr Tyr Ala Asn Trp Ala Glu 
    50                  55                  60                  


Gly Arg Phe Thr Ile Ser Lys Thr Ser Thr Thr Val Asp Leu Lys Met 
65                  70                  75                  80  


Thr Ser Leu Thr Thr Glu Asp Thr Ala Thr Tyr Phe Cys Ala Arg Gly 
                85                  90                  95      


Leu Val Asp Leu Asn Met Trp Gly Pro Gly Thr Leu Val Thr Val Ser 
            100                 105                 110         


Ser 
    


<210>  161
<211>  113
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  1-G5 VH

<400>  161

Ser Gln Ser Leu Glu Glu Ser Gly Gly Arg Leu Val Thr Pro Gly Thr 
1               5                   10                  15      


Pro Leu Thr Leu Thr Cys Ser Val Ser Gly Phe Ser Leu Ser Ser Tyr 
            20                  25                  30          


Asp Met Thr Trp Val Arg Gln Ala Pro Gly Lys Gly Leu Glu Trp Ile 
        35                  40                  45              


Gly Ser Ile His Ala Thr Gly Ile Thr Phe Tyr Ala Asn Trp Ala Lys 
    50                  55                  60                  


Gly Arg Phe Thr Thr Ser Lys Thr Ser Thr Thr Val Asp Leu Lys Met 
65                  70                  75                  80  


Thr Ser Leu Thr Thr Glu Asp Thr Ala Thr Tyr Phe Cys Ala Arg Gly 
                85                  90                  95      


Leu Val Asp Leu Asn Met Trp Gly Pro Gly Thr Leu Val Thr Val Ser 
            100                 105                 110         


Ser 
    


<210>  162
<211>  330
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  mAb HC

<400>  162

Ala Ser Thr Lys Gly Pro Ser Val Phe Pro Leu Ala Pro Ser Ser Lys 
1               5                   10                  15      


Ser Thr Ser Gly Gly Thr Ala Ala Leu Gly Cys Leu Val Lys Asp Tyr 
            20                  25                  30          


Phe Pro Glu Pro Val Thr Val Ser Trp Asn Ser Gly Ala Leu Thr Ser 
        35                  40                  45              


Gly Val His Thr Phe Pro Ala Val Leu Gln Ser Ser Gly Leu Tyr Ser 
    50                  55                  60                  


Leu Ser Ser Val Val Thr Val Pro Ser Ser Ser Leu Gly Thr Gln Thr 
65                  70                  75                  80  


Tyr Ile Cys Asn Val Asn His Lys Pro Ser Asn Thr Lys Val Asp Lys 
                85                  90                  95      


Lys Val Glu Pro Lys Ser Cys Asp Lys Thr His Thr Cys Pro Pro Cys 
            100                 105                 110         


Pro Ala Pro Glu Ala Ala Gly Gly Pro Ser Val Phe Leu Phe Pro Pro 
        115                 120                 125             


Lys Pro Lys Asp Thr Leu Met Ile Ser Arg Thr Pro Glu Val Thr Cys 
    130                 135                 140                 


Val Val Val Asp Val Ser His Glu Asp Pro Glu Val Lys Phe Asn Trp 
145                 150                 155                 160 


Tyr Val Asp Gly Val Glu Val His Asn Ala Lys Thr Lys Pro Arg Glu 
                165                 170                 175     


Glu Gln Tyr Asn Ser Thr Tyr Arg Val Val Ser Val Leu Thr Val Leu 
            180                 185                 190         


His Gln Asp Trp Leu Asn Gly Lys Glu Tyr Lys Cys Lys Val Ser Asn 
        195                 200                 205             


Lys Ala Leu Gly Ala Pro Ile Glu Lys Thr Ile Ser Lys Ala Lys Gly 
    210                 215                 220                 


Gln Pro Arg Glu Pro Gln Val Tyr Thr Leu Pro Pro Ser Arg Asp Glu 
225                 230                 235                 240 


Leu Thr Lys Asn Gln Val Ser Leu Thr Cys Leu Val Lys Gly Phe Tyr 
                245                 250                 255     


Pro Ser Asp Ile Ala Val Glu Trp Glu Ser Asn Gly Gln Pro Glu Asn 
            260                 265                 270         


Asn Tyr Lys Thr Thr Pro Pro Val Leu Asp Ser Asp Gly Ser Phe Phe 
        275                 280                 285             


Leu Tyr Ser Lys Leu Thr Val Asp Lys Ser Arg Trp Gln Gln Gly Asn 
    290                 295                 300                 


Val Phe Ser Cys Ser Val Met His Glu Ala Leu His Asn His Tyr Thr 
305                 310                 315                 320 


Gln Lys Ser Leu Ser Leu Ser Pro Gly Lys 
                325                 330 


<210>  163
<211>  107
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  mAb HC

<400>  163

Ala Ser Thr Lys Gly Pro Ser Val Phe Pro Leu Ala Pro Ser Ser Lys 
1               5                   10                  15      


Ser Thr Ser Gly Gly Thr Ala Ala Leu Gly Cys Leu Val Lys Asp Tyr 
            20                  25                  30          


Phe Pro Glu Pro Val Thr Val Ser Trp Asn Ser Gly Ala Leu Thr Ser 
        35                  40                  45              


Gly Val His Thr Phe Pro Ala Val Leu Gln Ser Ser Gly Leu Tyr Ser 
    50                  55                  60                  


Leu Ser Ser Val Val Thr Val Pro Ser Ser Ser Leu Gly Thr Gln Thr 
65                  70                  75                  80  


Tyr Ile Cys Asn Val Asn His Lys Pro Ser Asn Thr Lys Val Asp Lys 
                85                  90                  95      


Lys Val Glu Pro Ser Cys Gly Gly Gly Ser Lys 
            100                 105         


<210>  164
<211>  8
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  1-A2 and 4-H3 CDR-H1

<400>  164

Gly Phe Thr Phe Ser Ser Asn Ala 
1               5               


<210>  165
<211>  115
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  4-H3 and 1-A2 VH

<400>  165

Gln Val Gln Leu Val Glu Ser Gly Gly Gly Val Val Gln Pro Gly Arg 
1               5                   10                  15      


Ser Leu Arg Leu Ser Cys Ala Ala Ser Gly Phe Thr Phe Ser Ser Asn 
            20                  25                  30          


Ala Met Asn Trp Val Arg Gln Ala Pro Gly Lys Gly Leu Glu Trp Val 
        35                  40                  45              


Ala Gly Ile Tyr Gly His Asp Thr Ser Tyr Tyr Ala Ala Trp Ala Lys 
    50                  55                  60                  


Gly Arg Phe Thr Ile Ser Arg Asp Asn Ser Lys Asn Thr Leu Tyr Leu 
65                  70                  75                  80  


Gln Met Asn Ser Leu Arg Ala Glu Asp Thr Ala Val Tyr Tyr Cys Ala 
                85                  90                  95      


Arg Gly Phe Ile Tyr Phe Asp Ile Trp Gly Gln Gly Thr Leu Val Thr 
            100                 105                 110         


Val Ser Ser 
        115 


<210>  166
<211>  113
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  4-H3 VH

<400>  166

Gln Val Gln Leu Val Glu Ser Gly Gly Gly Val Val Gln Pro Gly Arg 
1               5                   10                  15      


Ser Leu Arg Leu Ser Cys Ala Ala Ser Gly Ile Asp Leu Thr Ser Asn 
            20                  25                  30          


Ala Met Asn Trp Val Arg Gln Ala Pro Gly Lys Gly Leu Glu Trp Val 
        35                  40                  45              


Ala Gly Ile Tyr Gly His Asp Thr Ser Tyr Tyr Ala Ala Trp Ala Lys 
    50                  55                  60                  


Gly Arg Phe Thr Ile Ser Arg Asp Ser Asn Thr Leu Tyr Leu Gln Met 
65                  70                  75                  80  


Asn Ser Leu Arg Ala Glu Asp Thr Ala Val Tyr Tyr Cys Ala Arg Gly 
                85                  90                  95      


Phe Ile Tyr Phe Asp Ile Trp Gly Gln Gly Thr Leu Val Thr Val Ser 
            100                 105                 110         


Ser 
    


<210>  167
<211>  115
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  4-H3 VH

<400>  167

Gln Val Gln Leu Val Glu Ser Gly Gly Gly Val Val Gln Pro Gly Arg 
1               5                   10                  15      


Ser Leu Arg Leu Ser Cys Ala Ala Ser Gly Ile Asp Leu Thr Ser Asn 
            20                  25                  30          


Ala Met Asn Trp Val Arg Gln Ala Pro Gly Lys Gly Leu Glu Trp Ile 
        35                  40                  45              


Gly Gly Ile Tyr Gly His Asp Thr Ser Tyr Tyr Ala Ala Trp Ala Lys 
    50                  55                  60                  


Gly Arg Phe Thr Ile Ser Arg Asp Asn Ser Lys Asn Thr Val Tyr Leu 
65                  70                  75                  80  


Gln Met Asn Ser Leu Arg Ala Glu Asp Thr Ala Val Tyr Tyr Cys Ala 
                85                  90                  95      


Arg Gly Phe Ile Tyr Phe Asp Ile Trp Gly Gln Gly Thr Leu Val Thr 
            100                 105                 110         


Val Ser Ser 
        115 


<210>  168
<211>  115
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  4-H3 VH

<400>  168

Gln Val Gln Leu Val Glu Ser Gly Gly Gly Val Val Gln Pro Gly Arg 
1               5                   10                  15      


Ser Leu Arg Leu Ser Cys Ala Ala Ser Gly Ile Asp Leu Thr Ser Asn 
            20                  25                  30          


Ala Met Asn Trp Val Arg Gln Ala Pro Gly Lys Gly Leu Glu Trp Val 
        35                  40                  45              


Ala Gly Ile Tyr Gly His Asp Thr Ser Tyr Tyr Ala Ala Trp Ala Lys 
    50                  55                  60                  


Gly Arg Phe Thr Ile Ser Arg Asp Asn Ser Lys Asn Thr Leu Tyr Leu 
65                  70                  75                  80  


Gln Met Asn Ser Leu Arg Ala Glu Asp Thr Ala Thr Tyr Phe Cys Ala 
                85                  90                  95      


Arg Gly Phe Ile Tyr Phe Asp Ile Trp Gly Gln Gly Thr Leu Val Thr 
            100                 105                 110         


Val Ser Ser 
        115 


<210>  169
<211>  114
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  4-H3 VH

<400>  169

Gln Gln Leu Val Glu Ser Gly Gly Gly Val Val Gln Pro Gly Arg Ser 
1               5                   10                  15      


Leu Arg Leu Ser Cys Ala Ala Ser Gly Ile Asp Leu Thr Ser Asn Ala 
            20                  25                  30          


Met Asn Trp Val Arg Gln Ala Pro Gly Lys Gly Leu Glu Trp Val Ala 
        35                  40                  45              


Gly Ile Tyr Gly His Asp Thr Ser Tyr Tyr Ala Ala Trp Ala Lys Gly 
    50                  55                  60                  


Arg Phe Thr Ile Ser Arg Asp Asn Ser Lys Asn Thr Leu Tyr Leu Gln 
65                  70                  75                  80  


Met Asn Ser Leu Arg Ala Glu Asp Thr Ala Val Tyr Tyr Cys Ala Arg 
                85                  90                  95      


Gly Phe Ile Tyr Phe Asp Ile Trp Gly Gln Gly Thr Leu Val Thr Val 
            100                 105                 110         


Ser Ser 
        


<210>  170
<211>  112
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  4-H3 VH

<400>  170

Gln Gln Leu Val Glu Ser Gly Gly Gly Val Val Gln Pro Gly Arg Ser 
1               5                   10                  15      


Leu Arg Leu Ser Cys Ala Ala Ser Gly Ile Asp Leu Thr Ser Asn Ala 
            20                  25                  30          


Met Asn Trp Val Arg Gln Ala Pro Gly Lys Gly Leu Glu Trp Val Ala 
        35                  40                  45              


Gly Ile Tyr Gly His Asp Thr Ser Tyr Tyr Ala Ala Trp Ala Lys Gly 
    50                  55                  60                  


Arg Phe Thr Ile Ser Arg Asp Ser Asn Thr Leu Tyr Leu Gln Met Asn 
65                  70                  75                  80  


Ser Leu Arg Ala Glu Asp Thr Ala Val Tyr Tyr Cys Ala Arg Gly Phe 
                85                  90                  95      


Ile Tyr Phe Asp Ile Trp Gly Gln Gly Thr Leu Val Thr Val Ser Ser 
            100                 105                 110         


<210>  171
<211>  115
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  4-H3 VH

<400>  171

Gln Val Gln Leu Val Glu Ser Gly Gly Gly Val Val Gln Pro Gly Arg 
1               5                   10                  15      


Ser Leu Arg Leu Ser Cys Ala Ala Ser Gly Ile Asp Leu Thr Ser Asn 
            20                  25                  30          


Ala Met Asn Trp Val Arg Gln Ala Pro Gly Lys Gly Leu Glu Trp Ile 
        35                  40                  45              


Gly Gly Ile Tyr Gly His Asp Thr Ser Tyr Tyr Ala Ala Trp Ala Lys 
    50                  55                  60                  


Gly Arg Phe Thr Ile Ser Arg Asp Asn Ser Lys Asn Thr Val Tyr Leu 
65                  70                  75                  80  


Gln Met Asn Ser Leu Arg Ala Glu Asp Thr Ala Thr Tyr Phe Cys Ala 
                85                  90                  95      


Arg Gly Phe Ile Tyr Phe Asp Ile Trp Gly Gln Gly Thr Leu Val Thr 
            100                 105                 110         


Val Ser Ser 
        115 


<210>  172
<211>  112
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  4-H3 and 1-A2 VH

<400>  172

Gln Gln Leu Val Glu Ser Gly Gly Gly Val Val Gln Pro Gly Arg Ser 
1               5                   10                  15      


Leu Arg Leu Ser Cys Ala Ala Ser Gly Ile Asp Leu Thr Ser Asn Ala 
            20                  25                  30          


Met Asn Trp Val Arg Gln Ala Pro Gly Lys Gly Leu Glu Trp Ile Gly 
        35                  40                  45              


Gly Ile Tyr Gly His Asp Thr Ser Tyr Tyr Ala Ala Trp Ala Lys Gly 
    50                  55                  60                  


Arg Phe Thr Ile Ser Arg Asp Ser Asn Thr Val Tyr Leu Gln Met Asn 
65                  70                  75                  80  


Ser Leu Arg Ala Glu Asp Thr Ala Thr Tyr Phe Cys Ala Arg Gly Phe 
                85                  90                  95      


Ile Tyr Phe Asp Ile Trp Gly Gln Gly Thr Leu Val Thr Val Ser Ser 
            100                 105                 110         


<210>  173
<211>  8
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  1-D5 CDR-H1

<400>  173

Gly Phe Thr Phe Ser Asn Tyr Ile 
1               5               


<210>  174
<211>  119
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  1-D5 VH

<400>  174

Gln Val Gln Leu Val Glu Ser Gly Gly Gly Val Val Gln Pro Gly Arg 
1               5                   10                  15      


Ser Leu Arg Leu Ser Cys Ala Ala Ser Gly Phe Thr Phe Ser Asn Tyr 
            20                  25                  30          


Ile Met Gly Trp Val Arg Gln Ala Pro Gly Lys Gly Leu Glu Trp Val 
        35                  40                  45              


Ala Ile Ile Ser Thr Gly Gly Ser Thr Tyr Tyr Ala Ser Trp Ala Lys 
    50                  55                  60                  


Gly Arg Phe Thr Ile Ser Arg Asp Asn Ser Lys Asn Thr Leu Tyr Leu 
65                  70                  75                  80  


Gln Met Asn Ser Leu Arg Ala Glu Asp Thr Ala Val Tyr Tyr Cys Ala 
                85                  90                  95      


Arg Gly Gly Ser Ser Ala Gly Ala Gly Phe Asn Ile Trp Gly Gln Gly 
            100                 105                 110         


Thr Leu Val Thr Val Ser Ser 
        115                 


<210>  175
<211>  119
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  1-D5 VH

<400>  175

Gln Val Gln Leu Val Glu Ser Gly Gly Gly Val Val Gln Pro Gly Arg 
1               5                   10                  15      


Ser Leu Arg Leu Ser Cys Ala Ala Ser Gly Phe Ser Leu Asn Asn Tyr 
            20                  25                  30          


Ile Met Gly Trp Val Arg Gln Ala Pro Gly Lys Gly Leu Glu Trp Val 
        35                  40                  45              


Ala Ile Ile Ser Thr Gly Gly Ser Thr Tyr Tyr Ala Ser Trp Ala Lys 
    50                  55                  60                  


Gly Arg Phe Thr Ile Ser Arg Asp Asn Ser Lys Asn Thr Leu Tyr Leu 
65                  70                  75                  80  


Gln Met Asn Ser Leu Arg Ala Glu Asp Thr Ala Val Tyr Tyr Cys Ala 
                85                  90                  95      


Arg Gly Gly Ser Ser Ala Gly Ala Gly Phe Asn Ile Trp Gly Gln Gly 
            100                 105                 110         


Thr Leu Val Thr Val Ser Ser 
        115                 


<210>  176
<211>  117
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  1-D5 VH

<400>  176

Gln Gln Gln Leu Val Glu Ser Gly Gly Gly Val Val Gln Pro Gly Arg 
1               5                   10                  15      


Ser Leu Arg Leu Ser Cys Ala Ala Ser Gly Phe Ser Leu Asn Asn Tyr 
            20                  25                  30          


Ile Met Gly Trp Val Arg Gln Ala Pro Gly Lys Gly Leu Glu Tyr Ile 
        35                  40                  45              


Gly Ile Ile Ser Thr Gly Gly Ser Thr Tyr Tyr Ala Ser Trp Ala Lys 
    50                  55                  60                  


Gly Arg Phe Thr Ile Ser Arg Asp Ser Asn Thr Met Tyr Leu Gln Met 
65                  70                  75                  80  


Asn Ser Leu Arg Ala Glu Asp Thr Ala Thr Tyr Phe Cys Ala Arg Gly 
                85                  90                  95      


Gly Ser Ser Ala Gly Ala Gly Phe Asn Ile Trp Gly Gln Gly Thr Leu 
            100                 105                 110         


Val Thr Val Ser Ser 
        115         


<210>  177
<211>  8
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  3-H9 CDR-H1

<400>  177

Gly Phe Thr Phe Ser Asn Tyr Asp 
1               5               


<210>  178
<211>  115
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  3-H9 VH

<400>  178

Gln Val Gln Leu Val Glu Ser Gly Gly Gly Val Val Gln Pro Gly Arg 
1               5                   10                  15      


Ser Leu Arg Leu Ser Cys Ala Ala Ser Gly Phe Thr Phe Ser Asn Tyr 
            20                  25                  30          


Asp Met Ser Trp Val Arg Gln Ala Pro Gly Lys Gly Leu Glu Trp Val 
        35                  40                  45              


Ala Ser Ile His Ala Ile Gly Ile Thr Tyr Tyr Ala Asn Trp Ala Glu 
    50                  55                  60                  


Gly Arg Phe Thr Ile Ser Arg Asp Asn Ser Lys Asn Thr Leu Tyr Leu 
65                  70                  75                  80  


Gln Met Asn Ser Leu Arg Ala Glu Asp Thr Ala Val Tyr Tyr Cys Ala 
                85                  90                  95      


Arg Gly Leu Val Asp Leu Asn Met Trp Gly Gln Gly Thr Leu Val Thr 
            100                 105                 110         


Val Ser Ser 
        115 


<210>  179
<211>  115
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  3-H9 VH

<400>  179

Gln Val Gln Leu Val Glu Ser Gly Gly Gly Val Val Gln Pro Gly Arg 
1               5                   10                  15      


Ser Leu Arg Leu Ser Cys Ala Ala Ser Gly Phe Ser Leu Ser Asn Tyr 
            20                  25                  30          


Asp Met Ser Trp Val Arg Gln Ala Pro Gly Lys Gly Leu Glu Trp Val 
        35                  40                  45              


Ala Ser Ile His Ala Ile Gly Ile Thr Tyr Tyr Ala Asn Trp Ala Glu 
    50                  55                  60                  


Gly Arg Phe Thr Ile Ser Arg Asp Asn Ser Lys Asn Thr Leu Tyr Leu 
65                  70                  75                  80  


Gln Met Asn Ser Leu Arg Ala Glu Asp Thr Ala Val Tyr Tyr Cys Ala 
                85                  90                  95      


Arg Gly Leu Val Asp Leu Asn Met Trp Gly Gln Gly Thr Leu Val Thr 
            100                 105                 110         


Val Ser Ser 
        115 


<210>  180
<211>  112
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  3-H9 VH

<400>  180

Gln Gln Leu Val Glu Ser Gly Gly Gly Val Val Gln Pro Gly Arg Ser 
1               5                   10                  15      


Leu Arg Leu Ser Cys Ala Ala Ser Gly Phe Ser Leu Ser Asn Tyr Asp 
            20                  25                  30          


Met Ser Trp Val Arg Gln Ala Pro Gly Lys Gly Leu Glu Trp Ile Gly 
        35                  40                  45              


Ser Ile His Ala Ile Gly Ile Thr Tyr Tyr Ala Asn Trp Ala Glu Gly 
    50                  55                  60                  


Arg Phe Thr Ile Ser Arg Asp Lys Asn Thr Val Tyr Leu Gln Met Asn 
65                  70                  75                  80  


Ser Leu Arg Ala Glu Asp Thr Ala Thr Tyr Phe Cys Ala Arg Gly Leu 
                85                  90                  95      


Val Asp Leu Asn Met Trp Gly Gln Gly Thr Leu Val Thr Val Ser Ser 
            100                 105                 110         


<210>  181
<211>  8
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  1-G5 CDR-H1

<400>  181

Gly Phe Thr Phe Ser Ser Tyr Asp 
1               5               


<210>  182
<211>  115
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  1-G5 VH

<400>  182

Gln Val Gln Leu Val Glu Ser Gly Gly Gly Val Val Gln Pro Gly Arg 
1               5                   10                  15      


Ser Leu Arg Leu Ser Cys Ala Ala Ser Gly Phe Thr Phe Ser Ser Tyr 
            20                  25                  30          


Asp Met Thr Trp Val Arg Gln Ala Pro Gly Lys Gly Leu Glu Trp Val 
        35                  40                  45              


Ala Ser Ile His Ala Thr Gly Ile Thr Phe Tyr Ala Asn Trp Ala Lys 
    50                  55                  60                  


Gly Arg Phe Thr Ile Ser Arg Asp Asn Ser Lys Asn Thr Leu Tyr Leu 
65                  70                  75                  80  


Gln Met Asn Ser Leu Arg Ala Glu Asp Thr Ala Val Tyr Tyr Cys Ala 
                85                  90                  95      


Arg Gly Leu Val Asp Leu Asn Met Trp Gly Gln Gly Thr Leu Val Thr 
            100                 105                 110         


Val Ser Ser 
        115 


<210>  183
<211>  115
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  1-G5 VH

<400>  183

Gln Val Gln Leu Val Glu Ser Gly Gly Gly Val Val Gln Pro Gly Arg 
1               5                   10                  15      


Ser Leu Arg Leu Ser Cys Ala Ala Ser Gly Phe Ser Leu Ser Ser Tyr 
            20                  25                  30          


Asp Met Thr Trp Val Arg Gln Ala Pro Gly Lys Gly Leu Glu Trp Val 
        35                  40                  45              


Ala Ser Ile His Ala Thr Gly Ile Thr Phe Tyr Ala Asn Trp Ala Lys 
    50                  55                  60                  


Gly Arg Phe Thr Ile Ser Arg Asp Asn Ser Lys Asn Thr Leu Tyr Leu 
65                  70                  75                  80  


Gln Met Asn Ser Leu Arg Ala Glu Asp Thr Ala Val Tyr Tyr Cys Ala 
                85                  90                  95      


Arg Gly Leu Val Asp Leu Asn Met Trp Gly Gln Gly Thr Leu Val Thr 
            100                 105                 110         


Val Ser Ser 
        115 


<210>  184
<211>  112
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  1-G5 VH

<400>  184

Gln Gln Leu Val Glu Ser Gly Gly Gly Val Val Gln Pro Gly Arg Ser 
1               5                   10                  15      


Leu Arg Leu Ser Cys Ala Ala Ser Gly Phe Ser Leu Ser Ser Tyr Asp 
            20                  25                  30          


Met Thr Trp Val Arg Gln Ala Pro Gly Lys Gly Leu Glu Trp Ile Gly 
        35                  40                  45              


Ser Ile His Ala Thr Gly Ile Thr Phe Tyr Ala Asn Trp Ala Lys Gly 
    50                  55                  60                  


Arg Phe Thr Thr Ser Lys Asp Ser Asn Thr Val Tyr Leu Gln Met Asn 
65                  70                  75                  80  


Ser Leu Arg Ala Glu Asp Thr Ala Thr Tyr Phe Cys Ala Arg Gly Leu 
                85                  90                  95      


Val Asp Leu Asn Met Trp Gly Gln Gly Thr Leu Val Thr Val Ser Ser 
            100                 105                 110         


<210>  185
<211>  110
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  4-H3 VL

<400>  185

Asp Ile Gln Met Thr Gln Ser Pro Ser Ser Leu Ser Ala Ser Val Gly 
1               5                   10                  15      


Asp Arg Val Thr Ile Thr Cys Leu Ala Ser Glu Asp Ile Ala Ser Gly 
            20                  25                  30          


Ile Ser Trp Tyr Gln Gln Lys Pro Gly Lys Ala Pro Lys Leu Leu Ile 
        35                  40                  45              


Tyr Gly Ala Ser Asn Leu Glu Ser Gly Val Pro Ser Arg Phe Ser Gly 
    50                  55                  60                  


Ser Gly Ser Gly Thr Asp Phe Thr Leu Thr Ile Ser Ser Leu Gln Pro 
65                  70                  75                  80  


Glu Asp Phe Ala Thr Tyr Tyr Cys Leu Gly Gly Tyr Ser Phe Ser Ser 
                85                  90                  95      


Asn Gly Leu Thr Phe Gly Gly Gly Thr Lys Val Glu Ile Lys 
            100                 105                 110 


<210>  186
<211>  110
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  4-H3 VL

<400>  186

Asp Tyr Gln Met Thr Gln Ser Pro Ser Ser Leu Ser Ala Ser Val Gly 
1               5                   10                  15      


Asp Arg Val Thr Ile Thr Cys Leu Ala Ser Glu Asp Ile Ala Ser Gly 
            20                  25                  30          


Ile Ser Trp Tyr Gln Gln Lys Pro Gly Lys Ala Pro Lys Leu Leu Ile 
        35                  40                  45              


Tyr Gly Ala Ser Asn Leu Glu Ser Gly Val Pro Ser Arg Phe Ser Gly 
    50                  55                  60                  


Ser Gly Ser Gly Thr Asp Tyr Thr Leu Thr Ile Ser Ser Leu Gln Pro 
65                  70                  75                  80  


Glu Asp Phe Ala Thr Tyr Tyr Cys Leu Gly Gly Tyr Ser Phe Ser Ser 
                85                  90                  95      


Asn Gly Leu Thr Phe Gly Gly Gly Thr Lys Val Glu Ile Lys 
            100                 105                 110 


<210>  187
<211>  110
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  1-D5 VL

<400>  187

Asp Ile Gln Met Thr Gln Ser Pro Ser Ser Leu Ser Ala Ser Val Gly 
1               5                   10                  15      


Asp Arg Val Thr Ile Thr Cys Gln Ala Ser Gln Ser Ile Asn Ser Gly 
            20                  25                  30          


Leu Ala Trp Tyr Gln Gln Lys Pro Gly Lys Ala Pro Lys Leu Leu Ile 
        35                  40                  45              


Tyr Lys Ala Ser Thr Leu Ala Ser Gly Val Pro Ser Arg Phe Ser Gly 
    50                  55                  60                  


Ser Gly Ser Gly Thr Asp Phe Thr Leu Thr Ile Ser Ser Leu Gln Pro 
65                  70                  75                  80  


Glu Asp Phe Ala Thr Tyr Tyr Cys Gln Ser Tyr His Tyr Ile Ser Ala 
                85                  90                  95      


Asn Gly Ala Thr Phe Gly Gly Gly Thr Lys Val Glu Ile Lys 
            100                 105                 110 


<210>  188
<211>  110
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  1-D5 VL

<400>  188

Asp Ile Gln Met Thr Gln Ser Pro Ser Ser Leu Ser Ala Ser Val Gly 
1               5                   10                  15      


Asp Arg Val Thr Ile Thr Cys Gln Ala Ser Gln Ser Ile Asn Ser Gly 
            20                  25                  30          


Leu Ala Trp Tyr Gln Gln Lys Pro Gly Lys Ala Pro Lys Arg Leu Ile 
        35                  40                  45              


Tyr Lys Ala Ser Thr Leu Ala Ser Gly Val Pro Ser Arg Phe Ser Gly 
    50                  55                  60                  


Ser Gly Ser Gly Thr Asp Phe Thr Leu Thr Ile Ser Ser Leu Gln Pro 
65                  70                  75                  80  


Glu Asp Phe Ala Thr Tyr Tyr Cys Gln Ser Tyr His Tyr Ile Ser Ala 
                85                  90                  95      


Asn Gly Ala Thr Phe Gly Gly Gly Thr Lys Val Glu Ile Lys 
            100                 105                 110 


<210>  189
<211>  112
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  3-H9 VL

<400>  189

Asp Ile Gln Met Thr Gln Ser Pro Ser Ser Leu Ser Ala Ser Val Gly 
1               5                   10                  15      


Asp Arg Val Thr Ile Thr Cys Gln Ser Ser Gln Ser Val Tyr Ser Asn 
            20                  25                  30          


Asn Leu Leu Ser Trp Tyr Gln Gln Lys Pro Gly Lys Ala Pro Lys Leu 
        35                  40                  45              


Leu Ile Tyr Asp Ala Ser Thr Leu Glu Ser Gly Val Pro Ser Arg Phe 
    50                  55                  60                  


Ser Gly Ser Gly Ser Gly Thr Asp Phe Thr Leu Thr Ile Ser Ser Leu 
65                  70                  75                  80  


Gln Pro Glu Asp Phe Ala Thr Tyr Tyr Cys Gln Gly Ser Tyr Tyr Ser 
                85                  90                  95      


Ser Gly Trp Tyr Asn Thr Phe Gly Gly Gly Thr Lys Val Glu Ile Lys 
            100                 105                 110         


<210>  190
<211>  110
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  1-A2 VL

<400>  190

Asp Ile Gln Met Thr Gln Ser Pro Ser Ser Leu Ser Ala Ser Val Gly 
1               5                   10                  15      


Asp Arg Val Thr Ile Thr Cys Leu Ala Ser Glu Asp Ile Tyr Ser Gly 
            20                  25                  30          


Ile Ser Trp Tyr Gln Gln Lys Pro Gly Lys Ala Pro Lys Leu Leu Ile 
        35                  40                  45              


Tyr Gly Ala Ser Asn Leu Glu Ser Gly Val Pro Ser Arg Phe Ser Gly 
    50                  55                  60                  


Ser Gly Ser Gly Thr Asp Phe Thr Leu Thr Ile Ser Ser Leu Gln Pro 
65                  70                  75                  80  


Glu Asp Phe Ala Thr Tyr Tyr Cys Leu Gly Gly His Ser His Ser Thr 
                85                  90                  95      


Thr Asp Leu Thr Phe Gly Gly Gly Thr Lys Val Glu Ile Lys 
            100                 105                 110 


<210>  191
<211>  110
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  1-A2 VL

<400>  191

Asp Ile Gln Met Thr Gln Ser Pro Ser Ser Leu Ser Ala Ser Val Gly 
1               5                   10                  15      


Asp Arg Val Thr Ile Thr Cys Leu Ala Ser Glu Asp Ile Tyr Ser Gly 
            20                  25                  30          


Ile Ser Trp Tyr Gln Gln Lys Pro Gly Lys Ala Pro Lys Leu Leu Ile 
        35                  40                  45              


Tyr Gly Ala Ser Asn Leu Glu Ser Gly Val Pro Ser Arg Phe Ser Gly 
    50                  55                  60                  


Ser Gly Ser Gly Thr Asp Tyr Thr Leu Thr Ile Ser Ser Leu Gln Pro 
65                  70                  75                  80  


Glu Asp Phe Ala Thr Tyr Tyr Cys Leu Gly Gly His Ser His Ser Thr 
                85                  90                  95      


Thr Asp Leu Thr Phe Gly Gly Gly Thr Lys Val Glu Ile Lys 
            100                 105                 110 


<210>  192
<211>  112
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  1-G5 VL

<400>  192

Asp Ile Gln Met Thr Gln Ser Pro Ser Ser Leu Ser Ala Ser Val Gly 
1               5                   10                  15      


Asp Arg Val Thr Ile Thr Cys Gln Ala Ser Gln Ser Val Tyr Asn Asn 
            20                  25                  30          


Asn Tyr Leu Ser Trp Tyr Gln Gln Lys Pro Gly Lys Ala Pro Lys Leu 
        35                  40                  45              


Leu Ile Tyr Asp Ala Ser Thr Leu Ala Ser Gly Val Pro Ser Arg Phe 
    50                  55                  60                  


Ser Gly Ser Gly Ser Gly Thr Asp Phe Thr Leu Thr Ile Ser Ser Leu 
65                  70                  75                  80  


Gln Pro Glu Asp Phe Ala Thr Tyr Tyr Cys Gln Gly Ser Tyr Tyr Ser 
                85                  90                  95      


Gly Gly Trp Asp Thr Ala Phe Gly Gly Gly Thr Lys Val Glu Ile Lys 
            100                 105                 110         


<210>  193
<211>  112
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  1-G5 VL

<400>  193

Asp Pro Gln Met Thr Gln Ser Pro Ser Ser Leu Ser Ala Ser Val Gly 
1               5                   10                  15      


Asp Arg Val Thr Ile Thr Cys Gln Ala Ser Gln Ser Val Tyr Asn Asn 
            20                  25                  30          


Asn Tyr Leu Ser Trp Tyr Gln Gln Lys Pro Gly Lys Ala Pro Lys Leu 
        35                  40                  45              


Leu Ile Tyr Asp Ala Ser Thr Leu Ala Ser Gly Val Pro Ser Arg Phe 
    50                  55                  60                  


Ser Gly Ser Gly Ser Gly Thr Asp Phe Thr Leu Thr Ile Ser Ser Leu 
65                  70                  75                  80  


Gln Pro Glu Asp Phe Ala Thr Tyr Tyr Cys Gln Gly Ser Tyr Tyr Ser 
                85                  90                  95      


Gly Gly Trp Asp Thr Ala Phe Gly Gly Gly Thr Lys Val Glu Ile Lys 
            100                 105                 110         


<210>  194
<211>  115
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  4-H3 and 1-A2 VH

<400>  194

Gln Val Gln Leu Val Glu Ser Gly Gly Gly Val Val Gln Pro Gly Arg 
1               5                   10                  15      


Ser Leu Arg Leu Ser Cys Ala Ala Ser Gly Ile Asp Leu Thr Ser Asn 
            20                  25                  30          


Ala Met Asn Trp Val Arg Gln Ala Pro Gly Lys Gly Leu Glu Trp Val 
        35                  40                  45              


Ala Gly Ile Tyr Gly His Asp Thr Ser Tyr Tyr Ala Ala Trp Ala Lys 
    50                  55                  60                  


Gly Arg Phe Thr Ile Ser Arg Asp Asn Ser Lys Asn Thr Leu Tyr Leu 
65                  70                  75                  80  


Gln Met Asn Ser Leu Arg Ala Glu Asp Thr Ala Val Tyr Tyr Cys Ala 
                85                  90                  95      


Arg Gly Phe Ile Tyr Phe Asp Ile Trp Gly Gln Gly Thr Leu Val Thr 
            100                 105                 110         


Val Ser Ser 
        115 


