                         SEQUENCE LISTING

<110>  Genovis AB
 
<120>  IMMUNOGLOBULIN CLEAVING ENZYME

<130>  P124344PCT

<140>  PCT/EP2022/060766
<141>  2022-04-22

<150>  EP 21169774.3
<151>  2021-04-22

<160>  27    

<170>  PatentIn version 3.5

<210>  1
<211>  557
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Full length sequence of protease isolated from Streptococcus 
       krosus (IdeSORK)

<400>  1

Leu Ser Lys Arg Lys Leu Leu Lys Lys Ile Glu Lys Lys Asp Thr Ser 
1               5                   10                  15      


Ser Val Leu Thr Gln Lys Lys Gln Thr Lys Thr Leu Trp Ala Asp Gly 
            20                  25                  30          


Val Gln Val Asp Asp Lys Asp Phe Lys Pro Ser Thr Glu Asn Phe Gly 
        35                  40                  45              


Thr Asn Tyr Leu Ala Ala Glu Tyr Gly Ile Gly Lys Gly Tyr Tyr Asp 
    50                  55                  60                  


Ile Asn Lys Lys Phe Asp Gly Thr Asp Asp Asp Leu Cys Ser Gly Val 
65                  70                  75                  80  


Val Ala Ala Asn Gln Leu His Trp Trp Leu Asp Arg Asn Lys Asp Tyr 
                85                  90                  95      


Ile Glu Lys Tyr Arg Gln Gln Ser Lys Asp Asn Gly Val Thr Ile Gly 
            100                 105                 110         


Asn Thr Asp Ile Phe Glu Leu Asn Lys Leu His Asp Glu Asp Gln Ser 
        115                 120                 125             


Asn Phe Phe Asp Phe Ile Lys Lys Ser Phe Gly Asn Lys Phe Leu Gln 
    130                 135                 140                 


Pro Glu Arg Leu Leu Asn Met Tyr Ile Asn Gly Tyr Gly Tyr Leu Thr 
145                 150                 155                 160 


Ser Gln Asp Lys Ala Lys Thr Ser Gln Pro Ser Pro Ser Lys Leu Asn 
                165                 170                 175     


Phe Phe Gln Lys Val Phe Lys Asn Asn Leu Leu Thr Asp Lys Thr Pro 
            180                 185                 190         


Ile Asn Asp Ile Asp Glu Phe Ser Ser Gln Thr Lys Asn Ala Leu Gln 
        195                 200                 205             


Asn His Lys Val Leu Ala Val Ser Phe Ala Ser Ile Lys Asn Arg Gly 
    210                 215                 220                 


Leu Gly His Val Val Thr Val Trp Gly Ala Asp Phe Asp Glu Asn Gly 
225                 230                 235                 240 


Lys Val Val Ala Leu Tyr Val Thr Asp Ser Asp Asp Arg Ser Lys Asn 
                245                 250                 255     


Ile Gly Asn Ala Lys Leu Gly Met Lys Lys Leu Arg Ile Glu Val Ser 
            260                 265                 270         


Ala Gln Asp Ser Ser Thr Ile Lys Leu Thr Gly Phe Glu Asp Lys Asn 
        275                 280                 285             


Ser Gly Gly Ser Leu Arg His Leu Tyr Ser Leu Ser Thr Gly Glu Gln 
    290                 295                 300                 


Ile Trp Lys Lys Tyr Phe Glu Glu Thr Glu Lys Glu Arg Ile Arg Leu 
305                 310                 315                 320 


Glu Glu Glu Ala Asp Lys Ala Lys Leu Glu Gln Asp Arg Ile Gln Lys 
                325                 330                 335     


Glu Ala Glu Glu Lys Leu Ala Leu Glu Lys Ala Glu Lys Glu Arg Ile 
            340                 345                 350         


Arg Leu Glu Glu Glu Ala Asp Lys Ala Lys Leu Glu Gln Asp Arg Ile 
        355                 360                 365             


Gln Lys Glu Ala Glu Glu Lys Leu Ala Leu Glu Lys Ala Glu Lys Glu 
    370                 375                 380                 


Arg Ile Arg Leu Glu Glu Glu Ala Asp Lys Ala Lys Leu Glu Gln Asp 
385                 390                 395                 400 


Arg Ile Gln Lys Glu Ala Glu Glu Lys Leu Ala Leu Glu Lys Ala Glu 
                405                 410                 415     


Lys Glu Arg Ile Arg Leu Glu Glu Glu Ala Asp Lys Ala Lys Leu Glu 
            420                 425                 430         


Gln Asp Arg Ile Gln Lys Glu Ala Glu Glu Lys Leu Ala Leu Glu Lys 
        435                 440                 445             


Ala Glu Lys Glu Arg Ile Arg Leu Glu Glu Glu Ala Ala Lys Ala Lys 
    450                 455                 460                 


Leu Glu Gln Glu Lys Gln Ile Ala Thr Ala Pro Gln Pro Asp Lys Lys 
465                 470                 475                 480 


Gln Glu Asn Thr Thr Ser Glu Gln Glu Lys Pro Ala Pro Thr Glu Leu 
                485                 490                 495     


Pro Pro Leu Val Asn Lys Ala Asp Glu Thr Glu Thr Pro Arg Glu Thr 
            500                 505                 510         


Ala Pro Asp Gln Thr Pro Ser Ala Thr Asn Thr Phe Arg Lys Ile Leu 
        515                 520                 525             


Pro Lys Met Asn Ala Val Ser Gln Phe Phe Ser Gln Leu Met Gly Thr 
    530                 535                 540                 


Ile Gln Ile Val Phe Ala Phe Ile Leu Lys Ile Phe Lys 
545                 550                 555         


<210>  2
<211>  312
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  N terminal fragment of IdeSORK

<400>  2

Ser Lys Arg Lys Leu Leu Lys Lys Ile Glu Lys Lys Asp Thr Ser Ser 
1               5                   10                  15      


Val Leu Thr Gln Lys Lys Gln Thr Lys Thr Leu Trp Ala Asp Gly Val 
            20                  25                  30          


Gln Val Asp Asp Lys Asp Phe Lys Pro Ser Thr Glu Asn Phe Gly Thr 
        35                  40                  45              


Asn Tyr Leu Ala Ala Glu Tyr Gly Ile Gly Lys Gly Tyr Tyr Asp Ile 
    50                  55                  60                  


Asn Lys Lys Phe Asp Gly Thr Asp Asp Asp Leu Cys Ser Gly Val Val 
65                  70                  75                  80  


Ala Ala Asn Gln Leu His Trp Trp Leu Asp Arg Asn Lys Asp Tyr Ile 
                85                  90                  95      


Glu Lys Tyr Arg Gln Gln Ser Lys Asp Asn Gly Val Thr Ile Gly Asn 
            100                 105                 110         


Thr Asp Ile Phe Glu Leu Asn Lys Leu His Asp Glu Asp Gln Ser Asn 
        115                 120                 125             


Phe Phe Asp Phe Ile Lys Lys Ser Phe Gly Asn Lys Phe Leu Gln Pro 
    130                 135                 140                 


Glu Arg Leu Leu Asn Met Tyr Ile Asn Gly Tyr Gly Tyr Leu Thr Ser 
145                 150                 155                 160 


Gln Asp Lys Ala Lys Thr Ser Gln Pro Ser Pro Ser Lys Leu Asn Phe 
                165                 170                 175     


Phe Gln Lys Val Phe Lys Asn Asn Leu Leu Thr Asp Lys Thr Pro Ile 
            180                 185                 190         


Asn Asp Ile Asp Glu Phe Ser Ser Gln Thr Lys Asn Ala Leu Gln Asn 
        195                 200                 205             


His Lys Val Leu Ala Val Ser Phe Ala Ser Ile Lys Asn Arg Gly Leu 
    210                 215                 220                 


Gly His Val Val Thr Val Trp Gly Ala Asp Phe Asp Glu Asn Gly Lys 
225                 230                 235                 240 


Val Val Ala Leu Tyr Val Thr Asp Ser Asp Asp Arg Ser Lys Asn Ile 
                245                 250                 255     


Gly Asn Ala Lys Leu Gly Met Lys Lys Leu Arg Ile Glu Val Ser Ala 
            260                 265                 270         


Gln Asp Ser Ser Thr Ile Lys Leu Thr Gly Phe Glu Asp Lys Asn Ser 
        275                 280                 285             


Gly Gly Ser Leu Arg His Leu Tyr Ser Leu Ser Thr Gly Glu Gln Ile 
    290                 295                 300                 


Trp Lys Lys Tyr Phe Glu Glu Thr 
305                 310         


<210>  3
<211>  319
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  (IdeSORK2.0) Protein of SEQ ID NO: 2 engineered to  include an 
       additional N terminal methionine and a C-terminal protein 
       purification tag - His6

<400>  3

Met Ser Lys Arg Lys Leu Leu Lys Lys Ile Glu Lys Lys Asp Thr Ser 
1               5                   10                  15      


Ser Val Leu Thr Gln Lys Lys Gln Thr Lys Thr Leu Trp Ala Asp Gly 
            20                  25                  30          


Val Gln Val Asp Asp Lys Asp Phe Lys Pro Ser Thr Glu Asn Phe Gly 
        35                  40                  45              


Thr Asn Tyr Leu Ala Ala Glu Tyr Gly Ile Gly Lys Gly Tyr Tyr Asp 
    50                  55                  60                  


Ile Asn Lys Lys Phe Asp Gly Thr Asp Asp Asp Leu Cys Ser Gly Val 
65                  70                  75                  80  


Val Ala Ala Asn Gln Leu His Trp Trp Leu Asp Arg Asn Lys Asp Tyr 
                85                  90                  95      


Ile Glu Lys Tyr Arg Gln Gln Ser Lys Asp Asn Gly Val Thr Ile Gly 
            100                 105                 110         


Asn Thr Asp Ile Phe Glu Leu Asn Lys Leu His Asp Glu Asp Gln Ser 
        115                 120                 125             


Asn Phe Phe Asp Phe Ile Lys Lys Ser Phe Gly Asn Lys Phe Leu Gln 
    130                 135                 140                 


Pro Glu Arg Leu Leu Asn Met Tyr Ile Asn Gly Tyr Gly Tyr Leu Thr 
145                 150                 155                 160 


Ser Gln Asp Lys Ala Lys Thr Ser Gln Pro Ser Pro Ser Lys Leu Asn 
                165                 170                 175     


Phe Phe Gln Lys Val Phe Lys Asn Asn Leu Leu Thr Asp Lys Thr Pro 
            180                 185                 190         


Ile Asn Asp Ile Asp Glu Phe Ser Ser Gln Thr Lys Asn Ala Leu Gln 
        195                 200                 205             


Asn His Lys Val Leu Ala Val Ser Phe Ala Ser Ile Lys Asn Arg Gly 
    210                 215                 220                 


Leu Gly His Val Val Thr Val Trp Gly Ala Asp Phe Asp Glu Asn Gly 
225                 230                 235                 240 


Lys Val Val Ala Leu Tyr Val Thr Asp Ser Asp Asp Arg Ser Lys Asn 
                245                 250                 255     


Ile Gly Asn Ala Lys Leu Gly Met Lys Lys Leu Arg Ile Glu Val Ser 
            260                 265                 270         


Ala Gln Asp Ser Ser Thr Ile Lys Leu Thr Gly Phe Glu Asp Lys Asn 
        275                 280                 285             


Ser Gly Gly Ser Leu Arg His Leu Tyr Ser Leu Ser Thr Gly Glu Gln 
    290                 295                 300                 


Ile Trp Lys Lys Tyr Phe Glu Glu Thr His His His His His His 
305                 310                 315                 


<210>  4
<211>  16
<212>  PRT
<213>  Homo sapiens

<400>  4

Cys Pro Pro Cys Pro Ala Pro Glu Leu Leu Gly Gly Pro Ser Val Phe 
1               5                   10                  15      


<210>  5
<211>  15
<212>  PRT
<213>  Homo sapiens

<400>  5

Cys Pro Pro Cys Pro Ala Pro Pro Val Ala Gly Pro Ser Val Phe 
1               5                   10                  15  


<210>  6
<211>  16
<212>  PRT
<213>  Homo sapiens

<400>  6

Cys Pro Arg Cys Pro Ala Pro Glu Leu Leu Gly Gly Pro Ser Val Phe 
1               5                   10                  15      


<210>  7
<211>  16
<212>  PRT
<213>  Homo sapiens

<400>  7

Ala His His Ala Gln Ala Pro Glu Phe Leu Gly Gly Pro Ser Val Phe 
1               5                   10                  15      


<210>  8
<211>  16
<212>  PRT
<213>  Mus musculus

<400>  8

Cys Pro Pro Cys Ala Ala Pro Asn Leu Leu Gly Gly Pro Ser Val Phe 
1               5                   10                  15      


<210>  9
<211>  16
<212>  PRT
<213>  Mus musculus

<400>  9

Gly Ser Ser Cys Pro Ala Gly Asn Ile Leu Gly Gly Pro Ser Val Phe 
1               5                   10                  15      


<210>  10
<211>  13
<212>  PRT
<213>  Mus musculus

<400>  10

Pro Cys Ile Cys Thr Val Pro Glu Val Ser Ser Val Phe 
1               5                   10              


<210>  11
<211>  16
<212>  PRT
<213>  Mus musculus

<400>  11

Cys His Lys Cys Pro Ala Pro Asn Leu Glu Gly Gly Pro Ser Val Phe 
1               5                   10                  15      


<210>  12
<211>  339
<212>  PRT
<213>  Streptococcus pyogenes

<400>  12

Met Arg Lys Arg Cys Tyr Ser Thr Ser Ala Ala Val Leu Ala Ala Val 
1               5                   10                  15      


Thr Leu Phe Val Leu Ser Val Asp Arg Gly Val Ile Ala Asp Ser Phe 
            20                  25                  30          


Ser Ala Asn Gln Glu Ile Arg Tyr Ser Glu Val Thr Pro Tyr His Val 
        35                  40                  45              


Thr Ser Val Trp Thr Lys Gly Val Thr Pro Pro Ala Asn Phe Thr Gln 
    50                  55                  60                  


Gly Glu Asp Val Phe His Ala Pro Tyr Val Ala Asn Gln Gly Trp Tyr 
65                  70                  75                  80  


Asp Ile Thr Lys Thr Phe Asn Gly Lys Asp Asp Leu Leu Cys Gly Ala 
                85                  90                  95      


Ala Thr Ala Gly Asn Met Leu His Trp Trp Phe Asp Gln Asn Lys Asp 
            100                 105                 110         


Gln Ile Lys Arg Tyr Leu Glu Glu His Pro Glu Lys Gln Lys Ile Asn 
        115                 120                 125             


Phe Asn Gly Glu Gln Met Phe Asp Val Lys Glu Ala Ile Asp Thr Lys 
    130                 135                 140                 


Asn His Gln Leu Asp Ser Lys Leu Phe Glu Tyr Phe Lys Glu Lys Ala 
145                 150                 155                 160 


Phe Pro Tyr Leu Ser Thr Lys His Leu Gly Val Phe Pro Asp His Val 
                165                 170                 175     


Ile Asp Met Phe Ile Asn Gly Tyr Arg Leu Ser Leu Thr Asn His Gly 
            180                 185                 190         


Pro Thr Pro Val Lys Glu Gly Ser Lys Asp Pro Arg Gly Gly Ile Phe 
        195                 200                 205             


Asp Ala Val Phe Thr Arg Gly Asp Gln Ser Lys Leu Leu Thr Ser Arg 
    210                 215                 220                 


His Asp Phe Lys Glu Lys Asn Leu Lys Glu Ile Ser Asp Leu Ile Lys 
225                 230                 235                 240 


Lys Glu Leu Thr Glu Gly Lys Ala Leu Gly Leu Ser His Thr Tyr Ala 
                245                 250                 255     


Asn Val Arg Ile Asn His Val Ile Asn Leu Trp Gly Ala Asp Phe Asp 
            260                 265                 270         


Ser Asn Gly Asn Leu Lys Ala Ile Tyr Val Thr Asp Ser Asp Ser Asn 
        275                 280                 285             


Ala Ser Ile Gly Met Lys Lys Tyr Phe Val Gly Val Asn Ser Ala Gly 
    290                 295                 300                 


Lys Val Ala Ile Ser Ala Lys Glu Ile Lys Glu Asp Asn Ile Gly Ala 
305                 310                 315                 320 


Gln Val Leu Gly Leu Phe Thr Leu Ser Thr Gly Gln Asp Ser Trp Asn 
                325                 330                 335     


Gln Thr Asn 
            


<210>  13
<211>  310
<212>  PRT
<213>  Streptococcus pyogenes

<400>  13

Asp Ser Phe Ser Ala Asn Gln Glu Ile Arg Tyr Ser Glu Val Thr Pro 
1               5                   10                  15      


Tyr His Val Thr Ser Val Trp Thr Lys Gly Val Thr Pro Pro Ala Asn 
            20                  25                  30          


Phe Thr Gln Gly Glu Asp Val Phe His Ala Pro Tyr Val Ala Asn Gln 
        35                  40                  45              


Gly Trp Tyr Asp Ile Thr Lys Thr Phe Asn Gly Lys Asp Asp Leu Leu 
    50                  55                  60                  


Cys Gly Ala Ala Thr Ala Gly Asn Met Leu His Trp Trp Phe Asp Gln 
65                  70                  75                  80  


Asn Lys Asp Gln Ile Lys Arg Tyr Leu Glu Glu His Pro Glu Lys Gln 
                85                  90                  95      


Lys Ile Asn Phe Asn Gly Glu Gln Met Phe Asp Val Lys Glu Ala Ile 
            100                 105                 110         


Asp Thr Lys Asn His Gln Leu Asp Ser Lys Leu Phe Glu Tyr Phe Lys 
        115                 120                 125             


Glu Lys Ala Phe Pro Tyr Leu Ser Thr Lys His Leu Gly Val Phe Pro 
    130                 135                 140                 


Asp His Val Ile Asp Met Phe Ile Asn Gly Tyr Arg Leu Ser Leu Thr 
145                 150                 155                 160 


Asn His Gly Pro Thr Pro Val Lys Glu Gly Ser Lys Asp Pro Arg Gly 
                165                 170                 175     


Gly Ile Phe Asp Ala Val Phe Thr Arg Gly Asp Gln Ser Lys Leu Leu 
            180                 185                 190         


Thr Ser Arg His Asp Phe Lys Glu Lys Asn Leu Lys Glu Ile Ser Asp 
        195                 200                 205             


Leu Ile Lys Lys Glu Leu Thr Glu Gly Lys Ala Leu Gly Leu Ser His 
    210                 215                 220                 


Thr Tyr Ala Asn Val Arg Ile Asn His Val Ile Asn Leu Trp Gly Ala 
225                 230                 235                 240 


Asp Phe Asp Ser Asn Gly Asn Leu Lys Ala Ile Tyr Val Thr Asp Ser 
                245                 250                 255     


Asp Ser Asn Ala Ser Ile Gly Met Lys Lys Tyr Phe Val Gly Val Asn 
            260                 265                 270         


Ser Ala Gly Lys Val Ala Ile Ser Ala Lys Glu Ile Lys Glu Asp Asn 
        275                 280                 285             


Ile Gly Ala Gln Val Leu Gly Leu Phe Thr Leu Ser Thr Gly Gln Asp 
    290                 295                 300                 


Ser Trp Asn Gln Thr Asn 
305                 310 


<210>  14
<211>  349
<212>  PRT
<213>  Streptococcus equi

<400>  14

Met Lys Thr Ile Ala Tyr Pro Asn Lys Pro His Ser Leu Ser Ala Gly 
1               5                   10                  15      


Leu Leu Thr Ala Ile Ala Ile Phe Ser Leu Ala Ser Ser Asn Ile Thr 
            20                  25                  30          


Tyr Ala Asp Asp Tyr Gln Arg Asn Ala Thr Glu Ala Tyr Ala Lys Glu 
        35                  40                  45              


Val Pro His Gln Ile Thr Ser Val Trp Thr Lys Gly Val Thr Pro Leu 
    50                  55                  60                  


Thr Pro Glu Gln Phe Arg Tyr Asn Asn Glu Asp Val Ile His Ala Pro 
65                  70                  75                  80  


Tyr Leu Ala His Gln Gly Trp Tyr Asp Ile Thr Lys Ala Phe Asp Gly 
                85                  90                  95      


Lys Asp Asn Leu Leu Cys Gly Ala Ala Thr Ala Gly Asn Met Leu His 
            100                 105                 110         


Trp Trp Phe Asp Gln Asn Lys Thr Glu Ile Glu Ala Tyr Leu Ser Lys 
        115                 120                 125             


His Pro Glu Lys Gln Lys Ile Ile Phe Asn Asn Gln Glu Leu Phe Asp 
    130                 135                 140                 


Leu Lys Ala Ala Ile Asp Thr Lys Asp Ser Gln Thr Asn Ser Gln Leu 
145                 150                 155                 160 


Phe Asn Tyr Phe Arg Asp Lys Ala Phe Pro Asn Leu Ser Ala Arg Gln 
                165                 170                 175     


Leu Gly Val Met Pro Asp Leu Val Leu Asp Met Phe Ile Asn Gly Tyr 
            180                 185                 190         


Tyr Leu Asn Val Phe Lys Thr Gln Ser Thr Asp Val Asn Arg Pro Tyr 
        195                 200                 205             


Gln Asp Lys Asp Lys Arg Gly Gly Ile Phe Asp Ala Val Phe Thr Arg 
    210                 215                 220                 


Gly Asp Gln Thr Thr Leu Leu Thr Ala Arg His Asp Leu Lys Asn Lys 
225                 230                 235                 240 


Gly Leu Asn Asp Ile Ser Thr Ile Ile Lys Gln Glu Leu Thr Glu Gly 
                245                 250                 255     


Arg Ala Leu Ala Leu Ser His Thr Tyr Ala Asn Val Ser Ile Ser His 
            260                 265                 270         


Val Ile Asn Leu Trp Gly Ala Asp Phe Asn Ala Glu Gly Asn Leu Glu 
        275                 280                 285             


Ala Ile Tyr Val Thr Asp Ser Asp Ala Asn Ala Ser Ile Gly Met Lys 
    290                 295                 300                 


Lys Tyr Phe Val Gly Ile Asn Ala His Gly His Val Ala Ile Ser Ala 
305                 310                 315                 320 


Lys Lys Ile Glu Gly Glu Asn Ile Gly Ala Gln Val Leu Gly Leu Phe 
                325                 330                 335     


Thr Leu Ser Ser Gly Lys Asp Ile Trp Gln Lys Leu Ser 
            340                 345                 


<210>  15
<211>  315
<212>  PRT
<213>  Streptococcus equi

<400>  15

Asp Asp Tyr Gln Arg Asn Ala Thr Glu Ala Tyr Ala Lys Glu Val Pro 
1               5                   10                  15      


His Gln Ile Thr Ser Val Trp Thr Lys Gly Val Thr Pro Leu Thr Pro 
            20                  25                  30          


Glu Gln Phe Arg Tyr Asn Asn Glu Asp Val Ile His Ala Pro Tyr Leu 
        35                  40                  45              


Ala His Gln Gly Trp Tyr Asp Ile Thr Lys Ala Phe Asp Gly Lys Asp 
    50                  55                  60                  


Asn Leu Leu Cys Gly Ala Ala Thr Ala Gly Asn Met Leu His Trp Trp 
65                  70                  75                  80  


Phe Asp Gln Asn Lys Thr Glu Ile Glu Ala Tyr Leu Ser Lys His Pro 
                85                  90                  95      


Glu Lys Gln Lys Ile Ile Phe Asn Asn Gln Glu Leu Phe Asp Leu Lys 
            100                 105                 110         


Ala Ala Ile Asp Thr Lys Asp Ser Gln Thr Asn Ser Gln Leu Phe Asn 
        115                 120                 125             


Tyr Phe Arg Asp Lys Ala Phe Pro Asn Leu Ser Ala Arg Gln Leu Gly 
    130                 135                 140                 


Val Met Pro Asp Leu Val Leu Asp Met Phe Ile Asn Gly Tyr Tyr Leu 
145                 150                 155                 160 


Asn Val Phe Lys Thr Gln Ser Thr Asp Val Asn Arg Pro Tyr Gln Asp 
                165                 170                 175     


Lys Asp Lys Arg Gly Gly Ile Phe Asp Ala Val Phe Thr Arg Gly Asp 
            180                 185                 190         


Gln Thr Thr Leu Leu Thr Ala Arg His Asp Leu Lys Asn Lys Gly Leu 
        195                 200                 205             


Asn Asp Ile Ser Thr Ile Ile Lys Gln Glu Leu Thr Glu Gly Arg Ala 
    210                 215                 220                 


Leu Ala Leu Ser His Thr Tyr Ala Asn Val Ser Ile Ser His Val Ile 
225                 230                 235                 240 


Asn Leu Trp Gly Ala Asp Phe Asn Ala Glu Gly Asn Leu Glu Ala Ile 
                245                 250                 255     


Tyr Val Thr Asp Ser Asp Ala Asn Ala Ser Ile Gly Met Lys Lys Tyr 
            260                 265                 270         


Phe Val Gly Ile Asn Ala His Gly His Val Ala Ile Ser Ala Lys Lys 
        275                 280                 285             


Ile Glu Gly Glu Asn Ile Gly Ala Gln Val Leu Gly Leu Phe Thr Leu 
    290                 295                 300                 


Ser Ser Gly Lys Asp Ile Trp Gln Lys Leu Ser 
305                 310                 315 


<210>  16
<211>  1701
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  exemplary nucleotide sequence encoding the polypeptide of SEQ ID 
       NO: 1

<400>  16
atgagcaagc gtaaactgct gaagaaaatc gagaagaaag acaccagcag cgtgctgacc       60

cagaagaaac aaaccaagac cctgtgggcg gatggcgtgc aggttgacga taaggacttc      120

aaaccgagca ccgaaaactt tggtaccaac tacctggcgg cggagtatgg tatcggcaag      180

ggttactacg atatcaacaa gaagttcgac ggcaccgacg atgacctgtg cagcggtgtg      240

gttgcggcga accagctgca ctggtggctg gatcgtaaca aggactacat tgaaaaatat      300

cgtcagcaaa gcaaggataa cggcgtgacc atcggtaaca ccgacatttt cgaactgaac      360

aaactgcacg atgaggacca gagcaacttc tttgatttca tcaagaaaag cttcggcaac      420

aagtttctgc aaccggagcg tctgctgaac atgtacatta acggctacgg ttatctgacc      480

agccaggata aggcgaaaac cagccaaccg agcccgagca agctgaactt ctttcagaag      540

gttttcaaaa acaacctgct gaccgacaaa accccgatca acgatattga cgaatttagc      600

agccagacca agaacgcgct gcaaaaccac aaagtgctgg cggttagctt cgcgagcatc      660

aagaaccgtg gcctgggtca cgtggttacc gtgtggggcg cggattttga cgagaacggt      720

aaagtggttg cgctgtatgt taccgacagc gatgaccgta gcaagaacat tggcaacgcg      780

aaactgggta tgaagaaact gcgtatcgaa gtgagcgcgc aggatagcag caccattaag      840

ctgaccggct tcgaggacaa aaacagcggt ggcagcctgc gtcacctgta cagcctgagc      900

accggtgaac aaatctggaa gaagtacttc gaggaaaccg aaaaggagcg tattcgtctg      960

gaggaagagg cggataaggc gaaactggaa caggaccgta tccaaaaaga ggcggaagag     1020

aaactggcgc tggaaaaggc ggaaaaagag cgtatccgtc tggaagagga agcggacaaa     1080

gcgaagctgg aacaagaccg tattcaaaaa gaggcggagg aaaaactggc gctggagaaa     1140

gcggagaagg aacgtatccg cctggaggaa gaggcggaca aagcgaaact ggaacaagat     1200

cgcattcaga aagaggcgga ggagaagctg gcgctggaaa aagcggagaa ggagcgcatt     1260

cgcctggaag aggaagcgga taaagcgaag ctggaacagg atcgcatcca gaaagaggcg     1320

gaagagaagc tggcgctgga gaaggcggag aaggagcgta tccgactgga ggaagaggcg     1380

gcgaaagcta aactggaaca agaaaaacaa attgcgaccg cgccgcagcc ggacaagaaa     1440

caagaaaaca ccaccagcga acaggagaaa ccggcgccga ccgagctgcc gccgctggtt     1500

aacaaagcgg atgaaaccga gaccccgcgt gagaccgcgc cggaccaaac cccgagcgcg     1560

accaacacct tccgtaagat cctgccgaaa atgaacgctg tgagccagtt ctttagccaa     1620

ctgatgggta ccatccagat tgttttcgcg tttatcctga agatttttaa aggcagcggt     1680

catcaccacc accaccacta a                                               1701


<210>  17
<211>  918
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  exemplary nucleotide sequence encoding the polypeptide of SEQ ID 
       NO: 2

<400>  17
atgagcaagc gtaaactgct gaagaaaatc gagaagaaag acaccagcag cgtgctgacc       60

cagaagaaac aaaccaagac cctgtgggcg gatggcgtgc aggttgacga taaggacttc      120

aaaccgagca ccgaaaactt tggtaccaac tacctggcgg cggagtatgg tatcggcaag      180

ggttactacg atatcaacaa gaagttcgac ggcaccgacg atgacctgtg cagcggtgtg      240

gttgcggcga accagctgca ctggtggctg gatcgtaaca aggactacat tgaaaaatat      300

cgtcagcaaa gcaaggataa cggcgtgacc atcggtaaca ccgacatttt cgaactgaac      360

aaactgcacg atgaggacca gagcaacttc tttgatttca tcaagaaaag cttcggcaac      420

aagtttctgc aaccggagcg tctgctgaac atgtacatta acggctacgg ttatctgacc      480

agccaggata aggcgaaaac cagccaaccg agcccgagca agctgaactt ctttcagaag      540

gttttcaaaa acaacctgct gaccgacaaa accccgatca acgatattga cgaatttagc      600

agccagacca agaacgcgct gcaaaaccac aaagtgctgg cggttagctt cgcgagcatc      660

aagaaccgtg gcctgggtca cgtggttacc gtgtggggcg cggattttga cgagaacggt      720

aaagtggttg cgctgtatgt taccgacagc gatgaccgta gcaagaacat tggcaacgcg      780

aaactgggta tgaagaaact gcgtatcgaa gtgagcgcgc aggatagcag caccattaag      840

ctgaccggct tcgaggacaa aaacagcggt ggcagcctgc gtcacctgta cagcctgcat      900

caccaccacc accactaa                                                    918


<210>  18
<211>  7068
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  exemplary expression vector sequence comprising the sequence of 
       SEQ ID NO : 16

<400>  18
tggcgaatgg gacgcgccct gtagcggcgc attaagcgcg gcgggtgtgg tggttacgcg       60

cagcgtgacc gctacacttg ccagcgccct agcgcccgct cctttcgctt tcttcccttc      120

ctttctcgcc acgttcgccg gctttccccg tcaagctcta aatcgggggc tccctttagg      180

gttccgattt agtgctttac ggcacctcga ccccaaaaaa cttgattagg gtgatggttc      240

acgtagtggg ccatcgccct gatagacggt ttttcgccct ttgacgttgg agtccacgtt      300

ctttaatagt ggactcttgt tccaaactgg aacaacactc aaccctatct cggtctattc      360

ttttgattta taagggattt tgccgatttc ggcctattgg ttaaaaaatg agctgattta      420

acaaaaattt aacgcgaatt ttaacaaaat attaacgttt acaatttcag gtggcacttt      480

tcggggaaat gtgcgcggaa cccctatttg tttatttttc taaatacatt caaatatgta      540

tccgctcatg agacaataac cctgataaat gcttcaataa tattgaaaaa ggaagagtat      600

gagtattcaa catttccgtg tcgcccttat tccctttttt gcggcatttt gccttcctgt      660

ttttgctcac ccagaaacgc tggtgaaagt aaaagatgct gaagatcagt tgggtgcacg      720

agtgggttac atcgaactgg atctcaacag cggtaagatc cttgagagtt ttcgccccga      780

agaacgtttt ccaatgatga gcacttttaa agttctgcta tgtggcgcgg tattatcccg      840

tattgacgcc gggcaagagc aactcggtcg ccgcatacac tattctcaga atgacttggt      900

tgagtactca ccagtcacag aaaagcatct tacggatggc atgacagtaa gagaattatg      960

cagtgctgcc ataaccatga gtgataacac tgcggccaac ttacttctga caacgatcgg     1020

aggaccgaag gagctaaccg cttttttgca caacatgggg gatcatgtaa ctcgccttga     1080

tcgttgggaa ccggagctga atgaagccat accaaacgac gagcgtgaca ccacgatgcc     1140

tgcagcaatg gcaacaacgt tgcgcaaact attaactggc gaactactta ctctagcttc     1200

ccggcaacaa ttaatagact ggatggaggc ggataaagtt gcaggaccac ttctgcgctc     1260

ggcccttccg gctggctggt ttattgctga taaatctgga gccggtgagc gtgggtctcg     1320

cggtatcatt gcagcactgg ggccagatgg taagccctcc cgtatcgtag ttatctacac     1380

gacggggagt caggcaacta tggatgaacg aaatagacag atcgctgaga taggtgcctc     1440

actgattaag cattggtaac tgtcagacca agtttactca tatatacttt agattgattt     1500

aaaacttcat ttttaattta aaaggatcta ggtgaagatc ctttttgata atctcatgac     1560

caaaatccct taacgtgagt tttcgttcca ctgagcgtca gaccccgtag aaaagatcaa     1620

aggatcttct tgagatcctt tttttctgcg cgtaatctgc tgcttgcaaa caaaaaaacc     1680

accgctacca gcggtggttt gtttgccgga tcaagagcta ccaactcttt ttccgaaggt     1740

aactggcttc agcagagcgc agataccaaa tactgtcctt ctagtgtagc cgtagttagg     1800

ccaccacttc aagaactctg tagcaccgcc tacatacctc gctctgctaa tcctgttacc     1860

agtggctgct gccagtggcg ataagtcgtg tcttaccggg ttggactcaa gacgatagtt     1920

accggataag gcgcagcggt cgggctgaac ggggggttcg tgcacacagc ccagcttgga     1980

gcgaacgacc tacaccgaac tgagatacct acagcgtgag ctatgagaaa gcgccacgct     2040

tcccgaaggg agaaaggcgg acaggtatcc ggtaagcggc agggtcggaa caggagagcg     2100

cacgagggag cttccagggg gaaacgcctg gtatctttat agtcctgtcg ggtttcgcca     2160

cctctgactt gagcgtcgat ttttgtgatg ctcgtcaggg gggcggagcc tatggaaaaa     2220

cgccagcaac gcggcctttt tacggttcct ggccttttgc tggccttttg ctcacatgtt     2280

ctttcctgcg ttatcccctg attctgtgga taaccgtatt accgcctttg agtgagctga     2340

taccgctcgc cgcagccgaa cgaccgagcg cagcgagtca gtgagcgagg aagcggaaga     2400

gcgcctgatg cggtattttc tccttacgca tctgtgcggt atttcacacc gcatatatgg     2460

tgcactctca gtacaatctg ctctgatgcc gcatagttaa gccagtatac actccgctat     2520

cgctacgtga ctgggtcatg gctgcgcccc gacacccgcc aacacccgct gacgcgccct     2580

gacgggcttg tctgctcccg gcatccgctt acagacaagc tgtgaccgtc tccgggagct     2640

gcatgtgtca gaggttttca ccgtcatcac cgaaacgcgc gaggcagctg cggtaaagct     2700

catcagcgtg gtcgtgaagc gattcacaga tgtctgcctg ttcatccgcg tccagctcgt     2760

tgagtttctc cagaagcgtt aatgtctggc ttctgataaa gcgggccatg ttaagggcgg     2820

ttttttcctg tttggtcact gatgcctccg tgtaaggggg atttctgttc atgggggtaa     2880

tgataccgat gaaacgagag aggatgctca cgatacgggt tactgatgat gaacatgccc     2940

ggttactgga acgttgtgag ggtaaacaac tggcggtatg gatgcggcgg gaccagagaa     3000

aaatcactca gggtcaatgc cagcgcttcg ttaatacaga tgtaggtgtt ccacagggta     3060

gccagcagca tcctgcgatg cagatccgga acataatggt gcagggcgct gacttccgcg     3120

tttccagact ttacgaaaca cggaaaccga agaccattca tgttgttgct caggtcgcag     3180

acgttttgca gcagcagtcg cttcacgttc gctcgcgtat cggtgattca ttctgctaac     3240

cagtaaggca accccgccag cctagccggg tcctcaacga caggagcacg atcatgcgca     3300

cccgtggggc cgccatgccg gcgataatgg cctgcttctc gccgaaacgt ttggtggcgg     3360

gaccagtgac gaaggcttga gcgagggcgt gcaagattcc gaataccgca agcgacaggc     3420

cgatcatcgt cgcgctccag cgaaagcggt cctcgccgaa aatgacccag agcgctgccg     3480

gcacctgtcc tacgagttgc atgataaaga agacagtcat aagtgcggcg acgatagtca     3540

tgccccgcgc ccaccggaag gagctgactg ggttgaaggc tctcaagggc atcggtcgag     3600

atcccggtgc ctaatgagtg agctaactta cattaattgc gttgcgctca ctgcccgctt     3660

tccagtcggg aaacctgtcg tgccagctgc attaatgaat cggccaacgc gcggggagag     3720

gcggtttgcg tattgggcgc cagggtggtt tttcttttca ccagtgagac gggcaacagc     3780

tgattgccct tcaccgcctg gccctgagag agttgcagca agcggtccac gctggtttgc     3840

cccagcaggc gaaaatcctg tttgatggtg gttaacggcg ggatataaca tgagctgtct     3900

tcggtatcgt cgtatcccac taccgagata tccgcaccaa cgcgcagccc ggactcggta     3960

atggcgcgca ttgcgcccag cgccatctga tcgttggcaa ccagcatcgc agtgggaacg     4020

atgccctcat tcagcatttg catggtttgt tgaaaaccgg acatggcact ccagtcgcct     4080

tcccgttccg ctatcggctg aatttgattg cgagtgagat atttatgcca gccagccaga     4140

cgcagacgcg ccgagacaga acttaatggg cccgctaaca gcgcgatttg ctggtgaccc     4200

aatgcgacca gatgctccac gcccagtcgc gtaccgtctt catgggagaa aataatactg     4260

ttgatgggtg tctggtcaga gacatcaaga aataacgccg gaacattagt gcaggcagct     4320

tccacagcaa tggcatcctg gtcatccagc ggatagttaa tgatcagccc actgacgcgt     4380

tgcgcgagaa gattgtgcac cgccgcttta caggcttcga cgccgcttcg ttctaccatc     4440

gacaccacca cgctggcacc cagttgatcg gcgcgagatt taatcgccgc gacaatttgc     4500

gacggcgcgt gcagggccag actggaggtg gcaacgccaa tcagcaacga ctgtttgccc     4560

gccagttgtt gtgccacgcg gttgggaatg taattcagct ccgccatcgc cgcttccact     4620

ttttcccgcg ttttcgcaga aacgtggctg gcctggttca ccacgcggga aacggtctga     4680

taagagacac cggcatactc tgcgacatcg tataacgtta ctggtttcac attcaccacc     4740

ctgaattgac tctcttccgg gcgctatcat gccataccgc gaaaggtttt gcgccattcg     4800

atggtgtccg ggatctcgac gctctccctt atgcgactcc tgcattagga agcagcccag     4860

tagtaggttg aggccgttga gcaccgccgc cgcaaggaat ggtgcatgca aggagatggc     4920

gcccaacagt cccccggcca cggggcctgc caccataccc acgccgaaac aagcgctcat     4980

gagcccgaag tggcgagccc gatcttcccc atcggtgatg tcggcgatat aggcgccagc     5040

aaccgcacct gtggcgccgg tgatgccggc cacgatgcgt ccggcgtaga ggatcgagat     5100

ctcgatcccg cgaaattaat acgactcact ataggggaat tgtgagcgga taacaattcc     5160

cctctagaaa taattttgtt taactttaag aaggagatat acatatgagc aagcgtaaac     5220

tgctgaagaa aatcgagaag aaagacacca gcagcgtgct gacccagaag aaacaaacca     5280

agaccctgtg ggcggatggc gtgcaggttg acgataagga cttcaaaccg agcaccgaaa     5340

actttggtac caactacctg gcggcggagt atggtatcgg caagggttac tacgatatca     5400

acaagaagtt cgacggcacc gacgatgacc tgtgcagcgg tgtggttgcg gcgaaccagc     5460

tgcactggtg gctggatcgt aacaaggact acattgaaaa atatcgtcag caaagcaagg     5520

ataacggcgt gaccatcggt aacaccgaca ttttcgaact gaacaaactg cacgatgagg     5580

accagagcaa cttctttgat ttcatcaaga aaagcttcgg caacaagttt ctgcaaccgg     5640

agcgtctgct gaacatgtac attaacggct acggttatct gaccagccag gataaggcga     5700

aaaccagcca accgagcccg agcaagctga acttctttca gaaggttttc aaaaacaacc     5760

tgctgaccga caaaaccccg atcaacgata ttgacgaatt tagcagccag accaagaacg     5820

cgctgcaaaa ccacaaagtg ctggcggtta gcttcgcgag catcaagaac cgtggcctgg     5880

gtcacgtggt taccgtgtgg ggcgcggatt ttgacgagaa cggtaaagtg gttgcgctgt     5940

atgttaccga cagcgatgac cgtagcaaga acattggcaa cgcgaaactg ggtatgaaga     6000

aactgcgtat cgaagtgagc gcgcaggata gcagcaccat taagctgacc ggcttcgagg     6060

acaaaaacag cggtggcagc ctgcgtcacc tgtacagcct gagcaccggt gaacaaatct     6120

ggaagaagta cttcgaggaa accgaaaagg agcgtattcg tctggaggaa gaggcggata     6180

aggcgaaact ggaacaggac cgtatccaaa aagaggcgga agagaaactg gcgctggaaa     6240

aggcggaaaa agagcgtatc cgtctggaag aggaagcgga caaagcgaag ctggaacaag     6300

accgtattca aaaagaggcg gaggaaaaac tggcgctgga gaaagcggag aaggaacgta     6360

tccgcctgga ggaagaggcg gacaaagcga aactggaaca agatcgcatt cagaaagagg     6420

cggaggagaa gctggcgctg gaaaaagcgg agaaggagcg cattcgcctg gaagaggaag     6480

cggataaagc gaagctggaa caggatcgca tccagaaaga ggcggaagag aagctggcgc     6540

tggagaaggc ggagaaggag cgtatccgac tggaggaaga ggcggcgaaa gctaaactgg     6600

aacaagaaaa acaaattgcg accgcgccgc agccggacaa gaaacaagaa aacaccacca     6660

gcgaacagga gaaaccggcg ccgaccgagc tgccgccgct ggttaacaaa gcggatgaaa     6720

ccgagacccc gcgtgagacc gcgccggacc aaaccccgag cgcgaccaac accttccgta     6780

agatcctgcc gaaaatgaac gctgtgagcc agttctttag ccaactgatg ggtaccatcc     6840

agattgtttt cgcgtttatc ctgaagattt ttaaaggcag cggtcatcac caccaccacc     6900

actaactcga gcaccaccac caccaccact gagatccggc tgctaacaaa gcccgaaagg     6960

aagctgagtt ggctgctgcc accgctgagc aataactagc ataacccctt ggggcctcta     7020

aacgggtctt gaggggtttt ttgctgaaag gaggaactat atccggat                  7068


<210>  19
<211>  6327
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  exemplary expression vector sequence comprising the sequence of 
       SEQ ID NO : 17

<400>  19
tggcgaatgg gacgcgccct gtagcggcgc attaagcgcg gcgggtgtgg tggttacgcg       60

cagcgtgacc gctacacttg ccagcgccct agcgcccgct cctttcgctt tcttcccttc      120

ctttctcgcc acgttcgccg gctttccccg tcaagctcta aatcgggggc tccctttagg      180

gttccgattt agtgctttac ggcacctcga ccccaaaaaa cttgattagg gtgatggttc      240

acgtagtggg ccatcgccct gatagacggt ttttcgccct ttgacgttgg agtccacgtt      300

ctttaatagt ggactcttgt tccaaactgg aacaacactc aaccctatct cggtctattc      360

ttttgattta taagggattt tgccgatttc ggcctattgg ttaaaaaatg agctgattta      420

acaaaaattt aacgcgaatt ttaacaaaat attaacgttt acaatttcag gtggcacttt      480

tcggggaaat gtgcgcggaa cccctatttg tttatttttc taaatacatt caaatatgta      540

tccgctcatg agacaataac cctgataaat gcttcaataa tattgaaaaa ggaagagtat      600

gagtattcaa catttccgtg tcgcccttat tccctttttt gcggcatttt gccttcctgt      660

ttttgctcac ccagaaacgc tggtgaaagt aaaagatgct gaagatcagt tgggtgcacg      720

agtgggttac atcgaactgg atctcaacag cggtaagatc cttgagagtt ttcgccccga      780

agaacgtttt ccaatgatga gcacttttaa agttctgcta tgtggcgcgg tattatcccg      840

tattgacgcc gggcaagagc aactcggtcg ccgcatacac tattctcaga atgacttggt      900

tgagtactca ccagtcacag aaaagcatct tacggatggc atgacagtaa gagaattatg      960

cagtgctgcc ataaccatga gtgataacac tgcggccaac ttacttctga caacgatcgg     1020

aggaccgaag gagctaaccg cttttttgca caacatgggg gatcatgtaa ctcgccttga     1080

tcgttgggaa ccggagctga atgaagccat accaaacgac gagcgtgaca ccacgatgcc     1140

tgcagcaatg gcaacaacgt tgcgcaaact attaactggc gaactactta ctctagcttc     1200

ccggcaacaa ttaatagact ggatggaggc ggataaagtt gcaggaccac ttctgcgctc     1260

ggcccttccg gctggctggt ttattgctga taaatctgga gccggtgagc gtgggtctcg     1320

cggtatcatt gcagcactgg ggccagatgg taagccctcc cgtatcgtag ttatctacac     1380

gacggggagt caggcaacta tggatgaacg aaatagacag atcgctgaga taggtgcctc     1440

actgattaag cattggtaac tgtcagacca agtttactca tatatacttt agattgattt     1500

aaaacttcat ttttaattta aaaggatcta ggtgaagatc ctttttgata atctcatgac     1560

caaaatccct taacgtgagt tttcgttcca ctgagcgtca gaccccgtag aaaagatcaa     1620

aggatcttct tgagatcctt tttttctgcg cgtaatctgc tgcttgcaaa caaaaaaacc     1680

accgctacca gcggtggttt gtttgccgga tcaagagcta ccaactcttt ttccgaaggt     1740

aactggcttc agcagagcgc agataccaaa tactgtcctt ctagtgtagc cgtagttagg     1800

ccaccacttc aagaactctg tagcaccgcc tacatacctc gctctgctaa tcctgttacc     1860

agtggctgct gccagtggcg ataagtcgtg tcttaccggg ttggactcaa gacgatagtt     1920

accggataag gcgcagcggt cgggctgaac ggggggttcg tgcacacagc ccagcttgga     1980

gcgaacgacc tacaccgaac tgagatacct acagcgtgag ctatgagaaa gcgccacgct     2040

tcccgaaggg agaaaggcgg acaggtatcc ggtaagcggc agggtcggaa caggagagcg     2100

cacgagggag cttccagggg gaaacgcctg gtatctttat agtcctgtcg ggtttcgcca     2160

cctctgactt gagcgtcgat ttttgtgatg ctcgtcaggg gggcggagcc tatggaaaaa     2220

cgccagcaac gcggcctttt tacggttcct ggccttttgc tggccttttg ctcacatgtt     2280

ctttcctgcg ttatcccctg attctgtgga taaccgtatt accgcctttg agtgagctga     2340

taccgctcgc cgcagccgaa cgaccgagcg cagcgagtca gtgagcgagg aagcggaaga     2400

gcgcctgatg cggtattttc tccttacgca tctgtgcggt atttcacacc gcatatatgg     2460

tgcactctca gtacaatctg ctctgatgcc gcatagttaa gccagtatac actccgctat     2520

cgctacgtga ctgggtcatg gctgcgcccc gacacccgcc aacacccgct gacgcgccct     2580

gacgggcttg tctgctcccg gcatccgctt acagacaagc tgtgaccgtc tccgggagct     2640

gcatgtgtca gaggttttca ccgtcatcac cgaaacgcgc gaggcagctg cggtaaagct     2700

catcagcgtg gtcgtgaagc gattcacaga tgtctgcctg ttcatccgcg tccagctcgt     2760

tgagtttctc cagaagcgtt aatgtctggc ttctgataaa gcgggccatg ttaagggcgg     2820

ttttttcctg tttggtcact gatgcctccg tgtaaggggg atttctgttc atgggggtaa     2880

tgataccgat gaaacgagag aggatgctca cgatacgggt tactgatgat gaacatgccc     2940

ggttactgga acgttgtgag ggtaaacaac tggcggtatg gatgcggcgg gaccagagaa     3000

aaatcactca gggtcaatgc cagcgcttcg ttaatacaga tgtaggtgtt ccacagggta     3060

gccagcagca tcctgcgatg cagatccgga acataatggt gcagggcgct gacttccgcg     3120

tttccagact ttacgaaaca cggaaaccga agaccattca tgttgttgct caggtcgcag     3180

acgttttgca gcagcagtcg cttcacgttc gctcgcgtat cggtgattca ttctgctaac     3240

cagtaaggca accccgccag cctagccggg tcctcaacga caggagcacg atcatgcgca     3300

cccgtggggc cgccatgccg gcgataatgg cctgcttctc gccgaaacgt ttggtggcgg     3360

gaccagtgac gaaggcttga gcgagggcgt gcaagattcc gaataccgca agcgacaggc     3420

cgatcatcgt cgcgctccag cgaaagcggt cctcgccgaa aatgacccag agcgctgccg     3480

gcacctgtcc tacgagttgc atgataaaga agacagtcat aagtgcggcg acgatagtca     3540

tgccccgcgc ccaccggaag gagctgactg ggttgaaggc tctcaagggc atcggtcgag     3600

atcccggtgc ctaatgagtg agctaactta cattaattgc gttgcgctca ctgcccgctt     3660

tccagtcggg aaacctgtcg tgccagctgc attaatgaat cggccaacgc gcggggagag     3720

gcggtttgcg tattgggcgc cagggtggtt tttcttttca ccagtgagac gggcaacagc     3780

tgattgccct tcaccgcctg gccctgagag agttgcagca agcggtccac gctggtttgc     3840

cccagcaggc gaaaatcctg tttgatggtg gttaacggcg ggatataaca tgagctgtct     3900

tcggtatcgt cgtatcccac taccgagata tccgcaccaa cgcgcagccc ggactcggta     3960

atggcgcgca ttgcgcccag cgccatctga tcgttggcaa ccagcatcgc agtgggaacg     4020

atgccctcat tcagcatttg catggtttgt tgaaaaccgg acatggcact ccagtcgcct     4080

tcccgttccg ctatcggctg aatttgattg cgagtgagat atttatgcca gccagccaga     4140

cgcagacgcg ccgagacaga acttaatggg cccgctaaca gcgcgatttg ctggtgaccc     4200

aatgcgacca gatgctccac gcccagtcgc gtaccgtctt catgggagaa aataatactg     4260

ttgatgggtg tctggtcaga gacatcaaga aataacgccg gaacattagt gcaggcagct     4320

tccacagcaa tggcatcctg gtcatccagc ggatagttaa tgatcagccc actgacgcgt     4380

tgcgcgagaa gattgtgcac cgccgcttta caggcttcga cgccgcttcg ttctaccatc     4440

gacaccacca cgctggcacc cagttgatcg gcgcgagatt taatcgccgc gacaatttgc     4500

gacggcgcgt gcagggccag actggaggtg gcaacgccaa tcagcaacga ctgtttgccc     4560

gccagttgtt gtgccacgcg gttgggaatg taattcagct ccgccatcgc cgcttccact     4620

ttttcccgcg ttttcgcaga aacgtggctg gcctggttca ccacgcggga aacggtctga     4680

taagagacac cggcatactc tgcgacatcg tataacgtta ctggtttcac attcaccacc     4740

ctgaattgac tctcttccgg gcgctatcat gccataccgc gaaaggtttt gcgccattcg     4800

atggtgtccg ggatctcgac gctctccctt atgcgactcc tgcattagga agcagcccag     4860

tagtaggttg aggccgttga gcaccgccgc cgcaaggaat ggtgcatgca aggagatggc     4920

gcccaacagt cccccggcca cggggcctgc caccataccc acgccgaaac aagcgctcat     4980

gagcccgaag tggcgagccc gatcttcccc atcggtgatg tcggcgatat aggcgccagc     5040

aaccgcacct gtggcgccgg tgatgccggc cacgatgcgt ccggcgtaga ggatcgagat     5100

ctcgatcccg cgaaattaat acgactcact ataggggaat tgtgagcgga taacaattcc     5160

cctctagaaa taattttgtt taactttaag aaggagatat acatatgagc aagcgtaaac     5220

tgctgaagaa aatcgagaag aaagacacca gcagcgtgct gacccagaag aaacaaacca     5280

agaccctgtg ggcggatggc gtgcaggttg acgataagga cttcaaaccg agcaccgaaa     5340

actttggtac caactacctg gcggcggagt atggtatcgg caagggttac tacgatatca     5400

acaagaagtt cgacggcacc gacgatgacc tgtgcagcgg tgtggttgcg gcgaaccagc     5460

tgcactggtg gctggatcgt aacaaggact acattgaaaa atatcgtcag caaagcaagg     5520

ataacggcgt gaccatcggt aacaccgaca ttttcgaact gaacaaactg cacgatgagg     5580

accagagcaa cttctttgat ttcatcaaga aaagcttcgg caacaagttt ctgcaaccgg     5640

agcgtctgct gaacatgtac attaacggct acggttatct gaccagccag gataaggcga     5700

aaaccagcca accgagcccg agcaagctga acttctttca gaaggttttc aaaaacaacc     5760

tgctgaccga caaaaccccg atcaacgata ttgacgaatt tagcagccag accaagaacg     5820

cgctgcaaaa ccacaaagtg ctggcggtta gcttcgcgag catcaagaac cgtggcctgg     5880

gtcacgtggt taccgtgtgg ggcgcggatt ttgacgagaa cggtaaagtg gttgcgctgt     5940

atgttaccga cagcgatgac cgtagcaaga acattggcaa cgcgaaactg ggtatgaaga     6000

aactgcgtat cgaagtgagc gcgcaggata gcagcaccat taagctgacc ggcttcgagg     6060

acaaaaacag cggtggcagc ctgcgtcacc tgtacagcct gagcaccggt gaacaaatct     6120

ggaagaagta cttcgaggaa acccatcacc accaccacca ctaactcgag caccaccacc     6180

accaccactg agatccggct gctaacaaag cccgaaagga agctgagttg gctgctgcca     6240

ccgctgagca ataactagca taaccccttg gggcctctaa acgggtcttg aggggttttt     6300

tgctgaaagg aggaactata tccggat                                         6327


<210>  20
<211>  566
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  IdeSork1.0

<400>  20

Met Ser Lys Arg Lys Leu Leu Lys Lys Ile Glu Lys Lys Asp Thr Ser 
1               5                   10                  15      


Ser Val Leu Thr Gln Lys Lys Gln Thr Lys Thr Leu Trp Ala Asp Gly 
            20                  25                  30          


Val Gln Val Asp Asp Lys Asp Phe Lys Pro Ser Thr Glu Asn Phe Gly 
        35                  40                  45              


Thr Asn Tyr Leu Ala Ala Glu Tyr Gly Ile Gly Lys Gly Tyr Tyr Asp 
    50                  55                  60                  


Ile Asn Lys Lys Phe Asp Gly Thr Asp Asp Asp Leu Cys Ser Gly Val 
65                  70                  75                  80  


Val Ala Ala Asn Gln Leu His Trp Trp Leu Asp Arg Asn Lys Asp Tyr 
                85                  90                  95      


Ile Glu Lys Tyr Arg Gln Gln Ser Lys Asp Asn Gly Val Thr Ile Gly 
            100                 105                 110         


Asn Thr Asp Ile Phe Glu Leu Asn Lys Leu His Asp Glu Asp Gln Ser 
        115                 120                 125             


Asn Phe Phe Asp Phe Ile Lys Lys Ser Phe Gly Asn Lys Phe Leu Gln 
    130                 135                 140                 


Pro Glu Arg Leu Leu Asn Met Tyr Ile Asn Gly Tyr Gly Tyr Leu Thr 
145                 150                 155                 160 


Ser Gln Asp Lys Ala Lys Thr Ser Gln Pro Ser Pro Ser Lys Leu Asn 
                165                 170                 175     


Phe Phe Gln Lys Val Phe Lys Asn Asn Leu Leu Thr Asp Lys Thr Pro 
            180                 185                 190         


Ile Asn Asp Ile Asp Glu Phe Ser Ser Gln Thr Lys Asn Ala Leu Gln 
        195                 200                 205             


Asn His Lys Val Leu Ala Val Ser Phe Ala Ser Ile Lys Asn Arg Gly 
    210                 215                 220                 


Leu Gly His Val Val Thr Val Trp Gly Ala Asp Phe Asp Glu Asn Gly 
225                 230                 235                 240 


Lys Val Val Ala Leu Tyr Val Thr Asp Ser Asp Asp Arg Ser Lys Asn 
                245                 250                 255     


Ile Gly Asn Ala Lys Leu Gly Met Lys Lys Leu Arg Ile Glu Val Ser 
            260                 265                 270         


Ala Gln Asp Ser Ser Thr Ile Lys Leu Thr Gly Phe Glu Asp Lys Asn 
        275                 280                 285             


Ser Gly Gly Ser Leu Arg His Leu Tyr Ser Leu Ser Thr Gly Glu Gln 
    290                 295                 300                 


Ile Trp Lys Lys Tyr Phe Glu Glu Thr Glu Lys Glu Arg Ile Arg Leu 
305                 310                 315                 320 


Glu Glu Glu Ala Asp Lys Ala Lys Leu Glu Gln Asp Arg Ile Gln Lys 
                325                 330                 335     


Glu Ala Glu Glu Lys Leu Ala Leu Glu Lys Ala Glu Lys Glu Arg Ile 
            340                 345                 350         


Arg Leu Glu Glu Glu Ala Asp Lys Ala Lys Leu Glu Gln Asp Arg Ile 
        355                 360                 365             


Gln Lys Glu Ala Glu Glu Lys Leu Ala Leu Glu Lys Ala Glu Lys Glu 
    370                 375                 380                 


Arg Ile Arg Leu Glu Glu Glu Ala Asp Lys Ala Lys Leu Glu Gln Asp 
385                 390                 395                 400 


Arg Ile Gln Lys Glu Ala Glu Glu Lys Leu Ala Leu Glu Lys Ala Glu 
                405                 410                 415     


Lys Glu Arg Ile Arg Leu Glu Glu Glu Ala Asp Lys Ala Lys Leu Glu 
            420                 425                 430         


Gln Asp Arg Ile Gln Lys Glu Ala Glu Glu Lys Leu Ala Leu Glu Lys 
        435                 440                 445             


Ala Glu Lys Glu Arg Ile Arg Leu Glu Glu Glu Ala Ala Lys Ala Lys 
    450                 455                 460                 


Leu Glu Gln Glu Lys Gln Ile Ala Thr Ala Pro Gln Pro Asp Lys Lys 
465                 470                 475                 480 


Gln Glu Asn Thr Thr Ser Glu Gln Glu Lys Pro Ala Pro Thr Glu Leu 
                485                 490                 495     


Pro Pro Leu Val Asn Lys Ala Asp Glu Thr Glu Thr Pro Arg Glu Thr 
            500                 505                 510         


Ala Pro Asp Gln Thr Pro Ser Ala Thr Asn Thr Phe Arg Lys Ile Leu 
        515                 520                 525             


Pro Lys Met Asn Ala Val Ser Gln Phe Phe Ser Gln Leu Met Gly Thr 
    530                 535                 540                 


Ile Gln Ile Val Phe Ala Phe Ile Leu Lys Ile Phe Lys Gly Ser Gly 
545                 550                 555                 560 


His His His His His His 
                565     


<210>  21
<211>  335
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  IdeS

<400>  21

Met Ala Ser Met Thr Gly Gly Gln Gln Met Gly Arg Asp Pro Leu Ala 
1               5                   10                  15      


Asp Ser Phe Ser Ala Asn Gln Glu Ile Arg Tyr Ser Glu Val Thr Pro 
            20                  25                  30          


Tyr His Val Thr Ser Val Trp Thr Lys Gly Val Thr Pro Pro Ala Asn 
        35                  40                  45              


Phe Thr Gln Gly Glu Asp Val Phe His Ala Pro Tyr Val Ala Asn Gln 
    50                  55                  60                  


Gly Trp Tyr Asp Ile Thr Lys Thr Phe Asn Gly Lys Asp Asp Leu Leu 
65                  70                  75                  80  


Cys Gly Ala Ala Thr Ala Gly Asn Met Leu His Trp Trp Phe Asp Gln 
                85                  90                  95      


Asn Lys Asp Gln Ile Lys Arg Tyr Leu Glu Glu His Pro Glu Lys Gln 
            100                 105                 110         


Lys Ile Asn Phe Asn Gly Glu Gln Met Phe Asp Val Lys Glu Ala Ile 
        115                 120                 125             


Asp Thr Lys Asn His Gln Leu Asp Ser Lys Leu Phe Glu Tyr Phe Lys 
    130                 135                 140                 


Glu Lys Ala Phe Pro Tyr Leu Ser Thr Lys His Leu Gly Val Phe Pro 
145                 150                 155                 160 


Asp His Val Ile Asp Met Phe Ile Asn Gly Tyr Arg Leu Ser Leu Thr 
                165                 170                 175     


Asn His Gly Pro Thr Pro Val Lys Glu Gly Ser Lys Asp Pro Arg Gly 
            180                 185                 190         


Gly Ile Phe Asp Ala Val Phe Thr Arg Gly Asp Gln Ser Lys Leu Leu 
        195                 200                 205             


Thr Ser Arg His Asp Phe Lys Glu Lys Asn Leu Lys Glu Ile Ser Asp 
    210                 215                 220                 


Leu Ile Lys Lys Glu Leu Thr Glu Gly Lys Ala Leu Gly Leu Ser His 
225                 230                 235                 240 


Thr Tyr Ala Asn Val Arg Ile Asn His Val Ile Asn Leu Trp Gly Ala 
                245                 250                 255     


Asp Phe Asp Ser Asn Gly Asn Leu Lys Ala Ile Tyr Val Thr Asp Ser 
            260                 265                 270         


Asp Ser Asn Ala Ser Ile Gly Met Lys Lys Tyr Phe Val Gly Val Asn 
        275                 280                 285             


Ser Ala Gly Lys Val Ala Ile Ser Ala Lys Glu Ile Lys Glu Asp Asn 
    290                 295                 300                 


Ile Gly Ala Gln Val Leu Gly Leu Phe Thr Leu Ser Thr Gly Gln Asp 
305                 310                 315                 320 


Ser Trp Asn Gln Thr Asn Ser Leu Glu His His His His His His 
                325                 330                 335 


<210>  22
<211>  322
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  IdeZ

<400>  22

Met Asp Asp Tyr Gln Arg Asn Ala Thr Glu Ala Tyr Ala Lys Glu Val 
1               5                   10                  15      


Pro His Gln Ile Thr Ser Val Trp Thr Lys Gly Val Thr Pro Leu Thr 
            20                  25                  30          


Pro Glu Gln Phe Arg Tyr Asn Asn Glu Asp Val Ile His Ala Pro Tyr 
        35                  40                  45              


Leu Ala His Gln Gly Trp Tyr Asp Ile Thr Lys Ala Phe Asp Gly Lys 
    50                  55                  60                  


Asp Asn Leu Leu Cys Gly Ala Ala Thr Ala Gly Asn Met Leu His Trp 
65                  70                  75                  80  


Trp Phe Asp Gln Asn Lys Thr Glu Ile Glu Ala Tyr Leu Ser Lys His 
                85                  90                  95      


Pro Glu Lys Gln Lys Ile Ile Phe Asn Asn Gln Glu Leu Phe Asp Leu 
            100                 105                 110         


Lys Ala Ala Ile Asp Thr Lys Asp Ser Gln Thr Asn Ser Gln Leu Phe 
        115                 120                 125             


Asn Tyr Phe Arg Asp Lys Ala Phe Pro Asn Leu Ser Ala Arg Gln Leu 
    130                 135                 140                 


Gly Val Met Pro Asp Leu Val Leu Asp Met Phe Ile Asn Gly Tyr Tyr 
145                 150                 155                 160 


Leu Asn Val Phe Lys Thr Gln Ser Thr Asp Val Asn Arg Pro Tyr Gln 
                165                 170                 175     


Asp Lys Asp Lys Arg Gly Gly Ile Phe Asp Ala Val Phe Thr Arg Gly 
            180                 185                 190         


Asp Gln Thr Thr Leu Leu Thr Ala Arg His Asp Leu Lys Asn Lys Gly 
        195                 200                 205             


Leu Asn Asp Ile Ser Thr Ile Ile Lys Gln Glu Leu Thr Glu Gly Arg 
    210                 215                 220                 


Ala Leu Ala Leu Ser His Thr Tyr Ala Asn Val Ser Ile Ser His Val 
225                 230                 235                 240 


Ile Asn Leu Trp Gly Ala Asp Phe Asn Ala Glu Gly Asn Leu Glu Ala 
                245                 250                 255     


Ile Tyr Val Thr Asp Ser Asp Ala Asn Ala Ser Ile Gly Met Lys Lys 
            260                 265                 270         


Tyr Phe Val Gly Ile Asn Ala His Gly His Val Ala Ile Ser Ala Lys 
        275                 280                 285             


Lys Ile Glu Gly Glu Asn Ile Gly Ala Gln Val Leu Gly Leu Phe Thr 
    290                 295                 300                 


Leu Ser Ser Gly Lys Asp Ile Trp Gln Lys Leu Ser His His His His 
305                 310                 315                 320 


His His 
        


<210>  23
<211>  313
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Xork

<400>  23

Met Ser Lys Arg Lys Leu Leu Lys Lys Ile Glu Lys Lys Asp Thr Ser 
1               5                   10                  15      


Ser Val Leu Thr Gln Lys Lys Gln Thr Lys Thr Leu Trp Ala Asp Gly 
            20                  25                  30          


Val Gln Val Asp Asp Lys Asp Phe Lys Pro Ser Thr Glu Asn Phe Gly 
        35                  40                  45              


Thr Asn Tyr Leu Ala Ala Glu Tyr Gly Ile Gly Lys Gly Tyr Tyr Asp 
    50                  55                  60                  


Ile Asn Lys Lys Phe Asp Gly Thr Asp Asp Asp Leu Cys Ser Gly Val 
65                  70                  75                  80  


Val Ala Ala Asn Gln Leu His Trp Trp Leu Asp Arg Asn Lys Asp Tyr 
                85                  90                  95      


Ile Glu Lys Tyr Arg Gln Gln Ser Lys Asp Asn Gly Val Thr Ile Gly 
            100                 105                 110         


Asn Thr Asp Ile Phe Glu Leu Asn Lys Leu His Asp Glu Asp Gln Ser 
        115                 120                 125             


Asn Phe Phe Asp Phe Ile Lys Lys Ser Phe Gly Asn Lys Phe Leu Gln 
    130                 135                 140                 


Pro Glu Arg Leu Leu Asn Met Tyr Ile Asn Gly Tyr Gly Tyr Leu Thr 
145                 150                 155                 160 


Ser Gln Asp Lys Ala Lys Thr Ser Gln Pro Ser Pro Ser Lys Leu Asn 
                165                 170                 175     


Phe Phe Gln Lys Val Phe Lys Asn Asn Leu Leu Thr Asp Lys Thr Pro 
            180                 185                 190         


Ile Asn Asp Ile Asp Glu Phe Ser Ser Gln Thr Lys Asn Ala Leu Gln 
        195                 200                 205             


Asn His Lys Val Leu Ala Val Ser Phe Ala Ser Ile Lys Asn Arg Gly 
    210                 215                 220                 


Leu Gly His Val Val Thr Val Trp Gly Ala Asp Phe Asp Glu Asn Gly 
225                 230                 235                 240 


Lys Val Val Ala Leu Tyr Val Thr Asp Ser Asp Asp Arg Ser Lys Asn 
                245                 250                 255     


Ile Gly Asn Ala Lys Leu Gly Met Lys Lys Leu Arg Ile Glu Val Ser 
            260                 265                 270         


Ala Gln Asp Ser Ser Thr Ile Lys Leu Thr Gly Phe Glu Asp Lys Asn 
        275                 280                 285             


Ser Gly Gly Ser Leu Arg His Leu Tyr Ser Leu Ser Thr Gly Glu Gln 
    290                 295                 300                 


Ile Trp Lys Lys Tyr Phe Glu Glu Thr 
305                 310             


<210>  24
<211>  329
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  IdeS

<400>  24

Met Ala Ser Met Thr Gly Gly Gln Gln Met Gly Arg Asp Pro Leu Ala 
1               5                   10                  15      


Asp Ser Phe Ser Ala Asn Gln Glu Ile Arg Tyr Ser Glu Val Thr Pro 
            20                  25                  30          


Tyr His Val Thr Ser Val Trp Thr Lys Gly Val Thr Pro Pro Ala Asn 
        35                  40                  45              


Phe Thr Gln Gly Glu Asp Val Phe His Ala Pro Tyr Val Ala Asn Gln 
    50                  55                  60                  


Gly Trp Tyr Asp Ile Thr Lys Thr Phe Asn Gly Lys Asp Asp Leu Leu 
65                  70                  75                  80  


Cys Gly Ala Ala Thr Ala Gly Asn Met Leu His Trp Trp Phe Asp Gln 
                85                  90                  95      


Asn Lys Asp Gln Ile Lys Arg Tyr Leu Glu Glu His Pro Glu Lys Gln 
            100                 105                 110         


Lys Ile Asn Phe Asn Gly Glu Gln Met Phe Asp Val Lys Glu Ala Ile 
        115                 120                 125             


Asp Thr Lys Asn His Gln Leu Asp Ser Lys Leu Phe Glu Tyr Phe Lys 
    130                 135                 140                 


Glu Lys Ala Phe Pro Tyr Leu Ser Thr Lys His Leu Gly Val Phe Pro 
145                 150                 155                 160 


Asp His Val Ile Asp Met Phe Ile Asn Gly Tyr Arg Leu Ser Leu Thr 
                165                 170                 175     


Asn His Gly Pro Thr Pro Val Lys Glu Gly Ser Lys Asp Pro Arg Gly 
            180                 185                 190         


Gly Ile Phe Asp Ala Val Phe Thr Arg Gly Asp Gln Ser Lys Leu Leu 
        195                 200                 205             


Thr Ser Arg His Asp Phe Lys Glu Lys Asn Leu Lys Glu Ile Ser Asp 
    210                 215                 220                 


Leu Ile Lys Lys Glu Leu Thr Glu Gly Lys Ala Leu Gly Leu Ser His 
225                 230                 235                 240 


Thr Tyr Ala Asn Val Arg Ile Asn His Val Ile Asn Leu Trp Gly Ala 
                245                 250                 255     


Asp Phe Asp Ser Asn Gly Asn Leu Lys Ala Ile Tyr Val Thr Asp Ser 
            260                 265                 270         


Asp Ser Asn Ala Ser Ile Gly Met Lys Lys Tyr Phe Val Gly Val Asn 
        275                 280                 285             


Ser Ala Gly Lys Val Ala Ile Ser Ala Lys Glu Ile Lys Glu Asp Asn 
    290                 295                 300                 


Ile Gly Ala Gln Val Leu Gly Leu Phe Thr Leu Ser Thr Gly Gln Asp 
305                 310                 315                 320 


Ser Trp Asn Gln Thr Asn Ser Leu Glu 
                325                 


<210>  25
<211>  316
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  IdeZ

<400>  25

Met Asp Asp Tyr Gln Arg Asn Ala Thr Glu Ala Tyr Ala Lys Glu Val 
1               5                   10                  15      


Pro His Gln Ile Thr Ser Val Trp Thr Lys Gly Val Thr Pro Leu Thr 
            20                  25                  30          


Pro Glu Gln Phe Arg Tyr Asn Asn Glu Asp Val Ile His Ala Pro Tyr 
        35                  40                  45              


Leu Ala His Gln Gly Trp Tyr Asp Ile Thr Lys Ala Phe Asp Gly Lys 
    50                  55                  60                  


Asp Asn Leu Leu Cys Gly Ala Ala Thr Ala Gly Asn Met Leu His Trp 
65                  70                  75                  80  


Trp Phe Asp Gln Asn Lys Thr Glu Ile Glu Ala Tyr Leu Ser Lys His 
                85                  90                  95      


Pro Glu Lys Gln Lys Ile Ile Phe Asn Asn Gln Glu Leu Phe Asp Leu 
            100                 105                 110         


Lys Ala Ala Ile Asp Thr Lys Asp Ser Gln Thr Asn Ser Gln Leu Phe 
        115                 120                 125             


Asn Tyr Phe Arg Asp Lys Ala Phe Pro Asn Leu Ser Ala Arg Gln Leu 
    130                 135                 140                 


Gly Val Met Pro Asp Leu Val Leu Asp Met Phe Ile Asn Gly Tyr Tyr 
145                 150                 155                 160 


Leu Asn Val Phe Lys Thr Gln Ser Thr Asp Val Asn Arg Pro Tyr Gln 
                165                 170                 175     


Asp Lys Asp Lys Arg Gly Gly Ile Phe Asp Ala Val Phe Thr Arg Gly 
            180                 185                 190         


Asp Gln Thr Thr Leu Leu Thr Ala Arg His Asp Leu Lys Asn Lys Gly 
        195                 200                 205             


Leu Asn Asp Ile Ser Thr Ile Ile Lys Gln Glu Leu Thr Glu Gly Arg 
    210                 215                 220                 


Ala Leu Ala Leu Ser His Thr Tyr Ala Asn Val Ser Ile Ser His Val 
225                 230                 235                 240 


Ile Asn Leu Trp Gly Ala Asp Phe Asn Ala Glu Gly Asn Leu Glu Ala 
                245                 250                 255     


Ile Tyr Val Thr Asp Ser Asp Ala Asn Ala Ser Ile Gly Met Lys Lys 
            260                 265                 270         


Tyr Phe Val Gly Ile Asn Ala His Gly His Val Ala Ile Ser Ala Lys 
        275                 280                 285             


Lys Ile Glu Gly Glu Asn Ile Gly Ala Gln Val Leu Gly Leu Phe Thr 
    290                 295                 300                 


Leu Ser Ser Gly Lys Asp Ile Trp Gln Lys Leu Ser 
305                 310                 315     


<210>  26
<211>  22
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Digestion site

<400>  26

Cys Pro Pro Cys Pro Ala Pro Glu Leu Leu Gly Gly Pro Ser Val Phe 
1               5                   10                  15      


Leu Phe Pro Pro Lys Pro 
            20          


<210>  27
<211>  22
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Digestion site

<400>  27

Cys Pro Pro Cys Pro Ala Pro Glu Ala Ala Gly Gly Pro Ser Val Phe 
1               5                   10                  15      


Leu Phe Pro Pro Lys Pro 
            20          


