                         SEQUENCE LISTING

<110>  Insusense ApS
 
<120>  COMPOUNDS

<130>  RMC00202WO

<140>  
<141>  2022-04-22

<150>  EP21170274.1
<151>  2021-04-23

<160>  3     

<170>  PatentIn version 3.5

<210>  1
<211>  831
<212>  PRT
<213>  Homo sapiens

<400>  1

Met Glu Arg Pro Trp Gly Ala Ala Asp Gly Leu Ser Arg Trp Pro His 
1               5                   10                  15      


Gly Leu Gly Leu Leu Leu Leu Leu Gln Leu Leu Pro Pro Ser Thr Leu 
            20                  25                  30          


Ser Gln Asp Arg Leu Asp Ala Pro Pro Pro Pro Ala Ala Pro Leu Pro 
        35                  40                  45              


Arg Trp Ser Gly Pro Ile Gly Val Ser Trp Gly Leu Arg Ala Ala Ala 
    50                  55                  60                  


Ala Gly Gly Ala Phe Pro Arg Gly Gly Arg Trp Arg Arg Ser Ala Pro 
65                  70                  75                  80  


Gly Glu Asp Glu Glu Cys Gly Arg Val Arg Asp Phe Val Ala Lys Leu 
                85                  90                  95      


Ala Asn Asn Thr His Gln His Val Phe Asp Asp Leu Arg Gly Ser Val 
            100                 105                 110         


Ser Leu Ser Trp Val Gly Asp Ser Thr Gly Val Ile Leu Val Leu Thr 
        115                 120                 125             


Thr Phe His Val Pro Leu Val Ile Met Thr Phe Gly Gln Ser Lys Leu 
    130                 135                 140                 


Tyr Arg Ser Glu Asp Tyr Gly Lys Asn Phe Lys Asp Ile Thr Asp Leu 
145                 150                 155                 160 


Ile Asn Asn Thr Phe Ile Arg Thr Glu Phe Gly Met Ala Ile Gly Pro 
                165                 170                 175     


Glu Asn Ser Gly Lys Val Val Leu Thr Ala Glu Val Ser Gly Gly Ser 
            180                 185                 190         


Arg Gly Gly Arg Ile Phe Arg Ser Ser Asp Phe Ala Lys Asn Phe Val 
        195                 200                 205             


Gln Thr Asp Leu Pro Phe His Pro Leu Thr Gln Met Met Tyr Ser Pro 
    210                 215                 220                 


Gln Asn Ser Asp Tyr Leu Leu Ala Leu Ser Thr Glu Asn Gly Leu Trp 
225                 230                 235                 240 


Val Ser Lys Asn Phe Gly Gly Lys Trp Glu Glu Ile His Lys Ala Val 
                245                 250                 255     


Cys Leu Ala Lys Trp Gly Ser Asp Asn Thr Ile Phe Phe Thr Thr Tyr 
            260                 265                 270         


Ala Asn Gly Ser Cys Lys Ala Asp Leu Gly Ala Leu Glu Leu Trp Arg 
        275                 280                 285             


Thr Ser Asp Leu Gly Lys Ser Phe Lys Thr Ile Gly Val Lys Ile Tyr 
    290                 295                 300                 


Ser Phe Gly Leu Gly Gly Arg Phe Leu Phe Ala Ser Val Met Ala Asp 
305                 310                 315                 320 


Lys Asp Thr Thr Arg Arg Ile His Val Ser Thr Asp Gln Gly Asp Thr 
                325                 330                 335     


Trp Ser Met Ala Gln Leu Pro Ser Val Gly Gln Glu Gln Phe Tyr Ser 
            340                 345                 350         


Ile Leu Ala Ala Asn Asp Asp Met Val Phe Met His Val Asp Glu Pro 
        355                 360                 365             


Gly Asp Thr Gly Phe Gly Thr Ile Phe Thr Ser Asp Asp Arg Gly Ile 
    370                 375                 380                 


Val Tyr Ser Lys Ser Leu Asp Arg His Leu Tyr Thr Thr Thr Gly Gly 
385                 390                 395                 400 


Glu Thr Asp Phe Thr Asn Val Thr Ser Leu Arg Gly Val Tyr Ile Thr 
                405                 410                 415     


Ser Val Leu Ser Glu Asp Asn Ser Ile Gln Thr Met Ile Thr Phe Asp 
            420                 425                 430         


Gln Gly Gly Arg Trp Thr His Leu Arg Lys Pro Glu Asn Ser Glu Cys 
        435                 440                 445             


Asp Ala Thr Ala Lys Asn Lys Asn Glu Cys Ser Leu His Ile His Ala 
    450                 455                 460                 


Ser Tyr Ser Ile Ser Gln Lys Leu Asn Val Pro Met Ala Pro Leu Ser 
465                 470                 475                 480 


Glu Pro Asn Ala Val Gly Ile Val Ile Ala His Gly Ser Val Gly Asp 
                485                 490                 495     


Ala Ile Ser Val Met Val Pro Asp Val Tyr Ile Ser Asp Asp Gly Gly 
            500                 505                 510         


Tyr Ser Trp Thr Lys Met Leu Glu Gly Pro His Tyr Tyr Thr Ile Leu 
        515                 520                 525             


Asp Ser Gly Gly Ile Ile Val Ala Ile Glu His Ser Ser Arg Pro Ile 
    530                 535                 540                 


Asn Val Ile Lys Phe Ser Thr Asp Glu Gly Gln Cys Trp Gln Thr Tyr 
545                 550                 555                 560 


Thr Phe Thr Arg Asp Pro Ile Tyr Phe Thr Gly Leu Ala Ser Glu Pro 
                565                 570                 575     


Gly Ala Arg Ser Met Asn Ile Ser Ile Trp Gly Phe Thr Glu Ser Phe 
            580                 585                 590         


Leu Thr Ser Gln Trp Val Ser Tyr Thr Ile Asp Phe Lys Asp Ile Leu 
        595                 600                 605             


Glu Arg Asn Cys Glu Glu Lys Asp Tyr Thr Ile Trp Leu Ala His Ser 
    610                 615                 620                 


Thr Asp Pro Glu Asp Tyr Glu Asp Gly Cys Ile Leu Gly Tyr Lys Glu 
625                 630                 635                 640 


Gln Phe Leu Arg Leu Arg Lys Ser Ser Met Cys Gln Asn Gly Arg Asp 
                645                 650                 655     


Tyr Val Val Thr Lys Gln Pro Ser Ile Cys Leu Cys Ser Leu Glu Asp 
            660                 665                 670         


Phe Leu Cys Asp Phe Gly Tyr Tyr Arg Pro Glu Asn Asp Ser Lys Cys 
        675                 680                 685             


Val Glu Gln Pro Glu Leu Lys Gly His Asp Leu Glu Phe Cys Leu Tyr 
    690                 695                 700                 


Gly Arg Glu Glu His Leu Thr Thr Asn Gly Tyr Arg Lys Ile Pro Gly 
705                 710                 715                 720 


Asp Lys Cys Gln Gly Gly Val Asn Pro Val Arg Glu Val Lys Asp Leu 
                725                 730                 735     


Lys Lys Lys Cys Thr Ser Asn Phe Leu Ser Pro Glu Lys Gln Asn Ser 
            740                 745                 750         


Lys Ser Asn Ser Val Pro Ile Ile Leu Ala Ile Val Gly Leu Met Leu 
        755                 760                 765             


Val Thr Val Val Ala Gly Val Leu Ile Val Lys Lys Tyr Val Cys Gly 
    770                 775                 780                 


Gly Arg Phe Leu Val His Arg Tyr Ser Val Leu Gln Gln His Ala Glu 
785                 790                 795                 800 


Ala Asn Gly Val Asp Gly Val Asp Ala Leu Asp Thr Ala Ser His Thr 
                805                 810                 815     


Asn Lys Ser Gly Tyr His Asp Asp Ser Asp Glu Asp Leu Leu Glu 
            820                 825                 830     


<210>  2
<211>  830
<212>  PRT
<213>  Homo sapiens

<400>  2

Met Glu Arg Pro Trp Gly Ala Ala Asp Gly Leu Ser Arg Trp Pro His 
1               5                   10                  15      


Gly Leu Gly Leu Leu Leu Leu Leu Gln Leu Leu Pro Pro Ser Thr Leu 
            20                  25                  30          


Ser Gln Asp Arg Leu Asp Ala Pro Pro Pro Pro Ala Ala Pro Leu Pro 
        35                  40                  45              


Arg Trp Ser Gly Pro Ile Gly Val Ser Trp Gly Leu Arg Ala Ala Ala 
    50                  55                  60                  


Ala Gly Gly Ala Phe Pro Arg Gly Gly Arg Trp Arg Arg Ser Ala Pro 
65                  70                  75                  80  


Gly Glu Asp Glu Glu Cys Gly Arg Val Arg Asp Phe Val Ala Lys Leu 
                85                  90                  95      


Ala Asn Asn Thr His Gln His Val Phe Asp Asp Leu Arg Gly Ser Val 
            100                 105                 110         


Ser Leu Ser Trp Val Gly Asp Ser Thr Gly Val Ile Leu Val Leu Thr 
        115                 120                 125             


Thr Phe His Val Pro Leu Val Ile Met Thr Phe Gly Gln Ser Lys Leu 
    130                 135                 140                 


Tyr Arg Ser Glu Asp Tyr Gly Lys Asn Phe Lys Asp Ile Thr Asp Leu 
145                 150                 155                 160 


Ile Asn Asn Thr Phe Ile Arg Thr Glu Phe Gly Met Ala Ile Gly Pro 
                165                 170                 175     


Glu Asn Ser Gly Lys Val Val Leu Thr Ala Glu Val Ser Gly Gly Ser 
            180                 185                 190         


Arg Gly Gly Arg Ile Phe Arg Ser Ser Asp Phe Ala Lys Asn Phe Val 
        195                 200                 205             


Gln Thr Asp Leu Pro Phe His Pro Leu Thr Gln Met Met Tyr Ser Pro 
    210                 215                 220                 


Gln Asn Ser Asp Tyr Leu Leu Ala Leu Ser Thr Glu Asn Gly Leu Trp 
225                 230                 235                 240 


Val Ser Lys Asn Phe Gly Gly Lys Trp Glu Glu Ile His Lys Ala Val 
                245                 250                 255     


Cys Leu Ala Lys Trp Gly Ser Asp Asn Thr Ile Phe Phe Thr Thr Tyr 
            260                 265                 270         


Ala Asn Gly Ser Cys Thr Asp Leu Gly Ala Leu Glu Leu Trp Arg Thr 
        275                 280                 285             


Ser Asp Leu Gly Lys Ser Phe Lys Thr Ile Gly Val Lys Ile Tyr Ser 
    290                 295                 300                 


Phe Gly Leu Gly Gly Arg Phe Leu Phe Ala Ser Val Met Ala Asp Lys 
305                 310                 315                 320 


Asp Thr Thr Arg Arg Ile His Val Ser Thr Asp Gln Gly Asp Thr Trp 
                325                 330                 335     


Ser Met Ala Gln Leu Pro Ser Val Gly Gln Glu Gln Phe Tyr Ser Ile 
            340                 345                 350         


Leu Ala Ala Asn Asp Asp Met Val Phe Met His Val Asp Glu Pro Gly 
        355                 360                 365             


Asp Thr Gly Phe Gly Thr Ile Phe Thr Ser Asp Asp Arg Gly Ile Val 
    370                 375                 380                 


Tyr Ser Lys Ser Leu Asp Arg His Leu Tyr Thr Thr Thr Gly Gly Glu 
385                 390                 395                 400 


Thr Asp Phe Thr Asn Val Thr Ser Leu Arg Gly Val Tyr Ile Thr Ser 
                405                 410                 415     


Val Leu Ser Glu Asp Asn Ser Ile Gln Thr Met Ile Thr Phe Asp Gln 
            420                 425                 430         


Gly Gly Arg Trp Thr His Leu Arg Lys Pro Glu Asn Ser Glu Cys Asp 
        435                 440                 445             


Ala Thr Ala Lys Asn Lys Asn Glu Cys Ser Leu His Ile His Ala Ser 
    450                 455                 460                 


Tyr Ser Ile Ser Gln Lys Leu Asn Val Pro Met Ala Pro Leu Ser Glu 
465                 470                 475                 480 


Pro Asn Ala Val Gly Ile Val Ile Ala His Gly Ser Val Gly Asp Ala 
                485                 490                 495     


Ile Ser Val Met Val Pro Asp Val Tyr Ile Ser Asp Asp Gly Gly Tyr 
            500                 505                 510         


Ser Trp Thr Lys Met Leu Glu Gly Pro His Tyr Tyr Thr Ile Leu Asp 
        515                 520                 525             


Ser Gly Gly Ile Ile Val Ala Ile Glu His Ser Ser Arg Pro Ile Asn 
    530                 535                 540                 


Val Ile Lys Phe Ser Thr Asp Glu Gly Gln Cys Trp Gln Thr Tyr Thr 
545                 550                 555                 560 


Phe Thr Arg Asp Pro Ile Tyr Phe Thr Gly Leu Ala Ser Glu Pro Gly 
                565                 570                 575     


Ala Arg Ser Met Asn Ile Ser Ile Trp Gly Phe Thr Glu Ser Phe Leu 
            580                 585                 590         


Thr Ser Gln Trp Val Ser Tyr Thr Ile Asp Phe Lys Asp Ile Leu Glu 
        595                 600                 605             


Arg Asn Cys Glu Glu Lys Asp Tyr Thr Ile Trp Leu Ala His Ser Thr 
    610                 615                 620                 


Asp Pro Glu Asp Tyr Glu Asp Gly Cys Ile Leu Gly Tyr Lys Glu Gln 
625                 630                 635                 640 


Phe Leu Arg Leu Arg Lys Ser Ser Val Cys Gln Asn Gly Arg Asp Tyr 
                645                 650                 655     


Val Val Thr Lys Gln Pro Ser Ile Cys Leu Cys Ser Leu Glu Asp Phe 
            660                 665                 670         


Leu Cys Asp Phe Gly Tyr Tyr Arg Pro Glu Asn Asp Ser Lys Cys Val 
        675                 680                 685             


Glu Gln Pro Glu Leu Lys Gly His Asp Leu Glu Phe Cys Leu Tyr Gly 
    690                 695                 700                 


Arg Glu Glu His Leu Thr Thr Asn Gly Tyr Arg Lys Ile Pro Gly Asp 
705                 710                 715                 720 


Lys Cys Gln Gly Gly Val Asn Pro Val Arg Glu Val Lys Asp Leu Lys 
                725                 730                 735     


Lys Lys Cys Thr Ser Asn Phe Leu Ser Pro Glu Lys Gln Asn Ser Lys 
            740                 745                 750         


Ser Asn Ser Val Pro Ile Ile Leu Ala Ile Val Gly Leu Met Leu Val 
        755                 760                 765             


Thr Val Val Ala Gly Val Leu Ile Val Lys Lys Tyr Val Cys Gly Gly 
    770                 775                 780                 


Arg Phe Leu Val His Arg Tyr Ser Val Leu Gln Gln His Ala Glu Ala 
785                 790                 795                 800 


Asn Gly Val Asp Gly Val Asp Ala Leu Asp Thr Ala Ser His Thr Asn 
                805                 810                 815     


Lys Ser Gly Tyr His Asp Asp Ser Asp Glu Asp Leu Leu Glu 
            820                 825                 830 


<210>  3
<211>  694
<212>  PRT
<213>  Homo sapiens

<400>  3

Met Thr Phe Gly Gln Ser Lys Leu Tyr Arg Ser Glu Asp Tyr Gly Lys 
1               5                   10                  15      


Asn Phe Lys Asp Ile Thr Asp Leu Ile Asn Asn Thr Phe Ile Arg Thr 
            20                  25                  30          


Glu Phe Gly Met Ala Ile Gly Pro Glu Asn Ser Gly Lys Val Val Leu 
        35                  40                  45              


Thr Ala Glu Val Ser Gly Gly Ser Arg Gly Gly Arg Ile Phe Arg Ser 
    50                  55                  60                  


Ser Asp Phe Ala Lys Asn Phe Val Gln Thr Asp Leu Pro Phe His Pro 
65                  70                  75                  80  


Leu Thr Gln Met Met Tyr Ser Pro Gln Asn Ser Asp Tyr Leu Leu Ala 
                85                  90                  95      


Leu Ser Thr Glu Asn Gly Leu Trp Val Ser Lys Asn Phe Gly Gly Lys 
            100                 105                 110         


Trp Glu Glu Ile His Lys Ala Val Cys Leu Ala Lys Trp Gly Ser Asp 
        115                 120                 125             


Asn Thr Ile Phe Phe Thr Thr Tyr Ala Asn Gly Ser Cys Thr Asp Leu 
    130                 135                 140                 


Gly Ala Leu Glu Leu Trp Arg Thr Ser Asp Leu Gly Lys Ser Phe Lys 
145                 150                 155                 160 


Thr Ile Gly Val Lys Ile Tyr Ser Phe Gly Leu Gly Gly Arg Phe Leu 
                165                 170                 175     


Phe Ala Ser Val Met Ala Asp Lys Asp Thr Thr Arg Arg Ile His Val 
            180                 185                 190         


Ser Thr Asp Gln Gly Asp Thr Trp Ser Met Ala Gln Leu Pro Ser Val 
        195                 200                 205             


Gly Gln Glu Gln Phe Tyr Ser Ile Leu Ala Ala Asn Asp Asp Met Val 
    210                 215                 220                 


Phe Met His Val Asp Glu Pro Gly Asp Thr Gly Phe Gly Thr Ile Phe 
225                 230                 235                 240 


Thr Ser Asp Asp Arg Gly Ile Val Tyr Ser Lys Ser Leu Asp Arg His 
                245                 250                 255     


Leu Tyr Thr Thr Thr Gly Gly Glu Thr Asp Phe Thr Asn Val Thr Ser 
            260                 265                 270         


Leu Arg Gly Val Tyr Ile Thr Ser Val Leu Ser Glu Asp Asn Ser Ile 
        275                 280                 285             


Gln Thr Met Ile Thr Phe Asp Gln Gly Gly Arg Trp Thr His Leu Arg 
    290                 295                 300                 


Lys Pro Glu Asn Ser Glu Cys Asp Ala Thr Ala Lys Asn Lys Asn Glu 
305                 310                 315                 320 


Cys Ser Leu His Ile His Ala Ser Tyr Ser Ile Ser Gln Lys Leu Asn 
                325                 330                 335     


Val Pro Met Ala Pro Leu Ser Glu Pro Asn Ala Val Gly Ile Val Ile 
            340                 345                 350         


Ala His Gly Ser Val Gly Asp Ala Ile Ser Val Met Val Pro Asp Val 
        355                 360                 365             


Tyr Ile Ser Asp Asp Gly Gly Tyr Ser Trp Thr Lys Met Leu Glu Gly 
    370                 375                 380                 


Pro His Tyr Tyr Thr Ile Leu Asp Ser Gly Gly Ile Ile Val Ala Ile 
385                 390                 395                 400 


Glu His Ser Ser Arg Pro Ile Asn Val Ile Lys Phe Ser Thr Asp Glu 
                405                 410                 415     


Gly Gln Cys Trp Gln Thr Tyr Thr Phe Thr Arg Asp Pro Ile Tyr Phe 
            420                 425                 430         


Thr Gly Leu Ala Ser Glu Pro Gly Ala Arg Ser Met Asn Ile Ser Ile 
        435                 440                 445             


Trp Gly Phe Thr Glu Ser Phe Leu Thr Ser Gln Trp Val Ser Tyr Thr 
    450                 455                 460                 


Ile Asp Phe Lys Asp Ile Leu Glu Arg Asn Cys Glu Glu Lys Asp Tyr 
465                 470                 475                 480 


Thr Ile Trp Leu Ala His Ser Thr Asp Pro Glu Asp Tyr Glu Asp Gly 
                485                 490                 495     


Cys Ile Leu Gly Tyr Lys Glu Gln Phe Leu Arg Leu Arg Lys Ser Ser 
            500                 505                 510         


Val Cys Gln Asn Gly Arg Asp Tyr Val Val Thr Lys Gln Pro Ser Ile 
        515                 520                 525             


Cys Leu Cys Ser Leu Glu Asp Phe Leu Cys Asp Phe Gly Tyr Tyr Arg 
    530                 535                 540                 


Pro Glu Asn Asp Ser Lys Cys Val Glu Gln Pro Glu Leu Lys Gly His 
545                 550                 555                 560 


Asp Leu Glu Phe Cys Leu Tyr Gly Arg Glu Glu His Leu Thr Thr Asn 
                565                 570                 575     


Gly Tyr Arg Lys Ile Pro Gly Asp Lys Cys Gln Gly Gly Val Asn Pro 
            580                 585                 590         


Val Arg Glu Val Lys Asp Leu Lys Lys Lys Cys Thr Ser Asn Phe Leu 
        595                 600                 605             


Ser Pro Glu Lys Gln Asn Ser Lys Ser Asn Ser Val Pro Ile Ile Leu 
    610                 615                 620                 


Ala Ile Val Gly Leu Met Leu Val Thr Val Val Ala Gly Val Leu Ile 
625                 630                 635                 640 


Val Lys Lys Tyr Val Cys Gly Gly Arg Phe Leu Val His Arg Tyr Ser 
                645                 650                 655     


Val Leu Gln Gln His Ala Glu Ala Asn Gly Val Asp Gly Val Asp Ala 
            660                 665                 670         


Leu Asp Thr Ala Ser His Thr Asn Lys Ser Gly Tyr His Asp Asp Ser 
        675                 680                 685             


Asp Glu Asp Leu Leu Glu 
    690                 


