                         SEQUENCE LISTING

<110>  Navigo Proteins GmbH
 
<120>  NOVEL HUMAN PROGRAMMED DEATH LIGAND 1 (PD-L1) SPECIFIC BINDING 
       MOLECULES

<130>  NP53 WO

<160>  26    

<170>  PatentIn version 3.5

<210>  1
<211>  82
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  PDL1 binding protein Affilin215306

<400>  1

Met Gln Ile Phe Val Lys Thr Leu Thr Glu Gln Ala Gln Glu His Gly 
1               5                   10                  15      


Lys Thr Ile Thr Leu Glu Val Glu Pro Ser Asp Thr Ile Glu Asn Val 
            20                  25                  30          


Lys Ala Lys Ile Gln Asp Lys Glu Gly Ile Pro Pro Asp Gln Gln Arg 
        35                  40                  45              


Leu Ile Trp Ala Gly Lys Gln Leu Glu Asp Gly Arg Thr Leu Ser Asp 
    50                  55                  60                  


Tyr Asn Ile Pro Tyr Trp Trp Pro Leu Phe Leu Phe Leu Gly Leu Arg 
65                  70                  75                  80  


Ala Ala 
        


<210>  2
<211>  82
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  PDL1 binding protein Affilin215220

<400>  2

Met Gln Ile Phe Val Lys Thr Leu Thr Phe Lys Ile Ile Pro Ala Gly 
1               5                   10                  15      


Lys Thr Ile Thr Leu Glu Val Glu Pro Ser Asp Thr Ile Glu Asn Val 
            20                  25                  30          


Lys Ala Lys Ile Gln Asp Lys Glu Gly Ile Pro Pro Asp Gln Gln Arg 
        35                  40                  45              


Leu Ile Trp Ala Gly Lys Gln Leu Glu Asp Gly Arg Thr Leu Ser Asp 
    50                  55                  60                  


Tyr Asn Ile Asp Trp Pro Ala Met Leu Thr Leu Ser Leu Pro Leu Arg 
65                  70                  75                  80  


Ala Ala 
        


<210>  3
<211>  80
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  PDL1 binding protein Affilin211904

<400>  3

Met Gln Ile Phe Val Lys Thr Leu Thr Val Leu Glu Met Gly Lys Thr 
1               5                   10                  15      


Ile Thr Leu Glu Val Glu Pro Ser Asp Thr Ile Glu Asn Val Lys Ala 
            20                  25                  30          


Lys Ile Gln Asp Lys Glu Gly Ile Pro Pro Asp Gln Gln Arg Leu Ile 
        35                  40                  45              


Trp Ala Gly Lys Gln Leu Glu Asp Gly Arg Thr Leu Ser Asp Tyr Asn 
    50                  55                  60                  


Ile His Ser Phe Pro Met Leu Glu Leu Leu Leu Thr Leu Arg Ala Ala 
65                  70                  75                  80  


<210>  4
<211>  80
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  PDL1 binding protein Affilin215208

<400>  4

Met Gln Ile Phe Val Lys Thr Leu Thr Val Tyr Glu Val Gly Lys Thr 
1               5                   10                  15      


Ile Thr Leu Glu Val Glu Pro Ser Asp Thr Ile Glu Asn Val Lys Ala 
            20                  25                  30          


Lys Ile Gln Asp Lys Glu Gly Ile Pro Pro Asp Gln Gln Arg Leu Ile 
        35                  40                  45              


Trp Ala Gly Lys Gln Leu Glu Asp Gly Arg Thr Leu Ser Asp Tyr Asn 
    50                  55                  60                  


Ile Phe Ala Leu Pro Met Leu Glu Leu Leu Leu Thr Leu Arg Ala Ala 
65                  70                  75                  80  


<210>  5
<211>  76
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  PDL1 binding protein Affilin211620

<400>  5

Met Gln Ile Phe Val Trp Thr Ile Ile Thr Lys Arg Ile Thr Leu Glu 
1               5                   10                  15      


Val Glu Pro Ser Asp Thr Ile Glu Asn Val Lys Ala Lys Ile Gln Asp 
            20                  25                  30          


Lys Glu Gly Ile Pro Pro Asp Gln Gln His Leu Val Trp Glu Gly Lys 
        35                  40                  45              


Gln Leu Glu Asp Gly Arg Thr Leu Ser Asp Tyr Asn Ile Glu Lys Tyr 
    50                  55                  60                  


Asp Tyr Leu Phe Leu Asn Leu His Leu Arg Ala Ala 
65                  70                  75      


<210>  6
<211>  76
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  PDL1 binding protein Affilin215258

<400>  6

Met Gln Ile Phe Val Val Thr Glu Glu Asp Lys Val Ile Thr Leu Glu 
1               5                   10                  15      


Val Glu Pro Ser Asp Thr Ile Glu Asn Val Lys Ala Lys Ile Gln Asp 
            20                  25                  30          


Lys Glu Gly Ile Pro Pro Asp Gln Gln Met Leu His Trp Ser Gly Lys 
        35                  40                  45              


Gln Leu Glu Asp Gly Arg Thr Leu Ser Asp Tyr Asn Ile Phe Asp Ala 
    50                  55                  60                  


Lys Ile Leu Leu Leu His Leu Ile Leu Arg Ala Ala 
65                  70                  75      


<210>  7
<211>  152
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  PDL1 binding protein Affilin211960

<400>  7

Met Gln Ile Phe Val Gln Thr Asp Thr Gly Lys Thr Ile Thr Leu Glu 
1               5                   10                  15      


Val Glu Pro Ser Asp Thr Ile Glu Asn Val Lys Ala Lys Ile Gln Asp 
            20                  25                  30          


Lys Glu Gly Ile Pro Pro Asp Gln Gln Arg Leu Ile Trp Ala Gly Lys 
        35                  40                  45              


Gln Leu Glu Asp Gly Arg Thr Leu Ser Asp Tyr Asn Ile Gly Ile Val 
    50                  55                  60                  


Ala Pro Leu His Leu Val Leu Arg Leu Arg Ala Ala Met Gln Ile Phe 
65                  70                  75                  80  


Val Phe Thr Trp Thr Gly Lys Thr Ile Thr Leu Glu Val Glu Pro Ser 
                85                  90                  95      


Asp Thr Ile Glu Asn Val Lys Ala Lys Ile Gln Asp Lys Glu Gly Ile 
            100                 105                 110         


Pro Pro Asp Gln Gln Arg Leu Ile Trp Ala Gly Lys Gln Leu Glu Asp 
        115                 120                 125             


Gly Arg Thr Leu Ser Asp Tyr Asn Ile Gly Asn Gly Trp Met Leu His 
    130                 135                 140                 


Leu Val Leu Arg Leu Arg Ala Ala 
145                 150         


<210>  8
<211>  152
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  PDL1 binding protein Affilin211944

<400>  8

Met Gln Ile Phe Val Phe Thr Ala Thr Gly Lys Thr Ile Thr Leu Glu 
1               5                   10                  15      


Val Glu Pro Ser Asp Thr Ile Glu Asn Val Lys Ala Lys Ile Gln Asp 
            20                  25                  30          


Lys Glu Gly Ile Pro Pro Asp Gln Gln Arg Leu Ile Trp Ala Gly Lys 
        35                  40                  45              


Gln Leu Glu Asp Gly Arg Thr Leu Ser Asp Tyr Asn Ile Arg Ser Gly 
    50                  55                  60                  


Trp Met Leu His Leu Val Leu Arg Leu Arg Ala Ala Met Gln Ile Phe 
65                  70                  75                  80  


Val Ala Thr Tyr Thr Gly Lys Thr Ile Thr Leu Glu Val Glu Pro Ser 
                85                  90                  95      


Asp Thr Ile Glu Asn Val Lys Ala Lys Ile Gln Asp Lys Glu Gly Ile 
            100                 105                 110         


Pro Pro Asp Gln Gln Arg Leu Ile Trp Ala Gly Lys Gln Leu Glu Asp 
        115                 120                 125             


Gly Arg Thr Leu Ser Asp Tyr Asn Ile His Glu Pro Glu Thr Leu His 
    130                 135                 140                 


Leu Val Leu Arg Leu Arg Ala Ala 
145                 150         


<210>  9
<211>  152
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  PDL1 binding protein Affilin211828

<400>  9

Met Gln Ile Phe Val Asp Thr Leu Thr Gly Lys Thr Ile Thr Leu Glu 
1               5                   10                  15      


Val Glu Pro Ser Asp Thr Ile Glu Asn Val Lys Ala Lys Ile Gln Asp 
            20                  25                  30          


Lys Glu Gly Ile Pro Pro Asp Gln Gln Arg Leu Ile Trp Ala Gly Lys 
        35                  40                  45              


Gln Leu Glu Asp Gly Arg Thr Leu Ser Asp Tyr Asn Ile Arg Tyr Pro 
    50                  55                  60                  


Ala Phe Leu His Leu Val Leu Arg Leu Arg Ala Ala Met Gln Ile Phe 
65                  70                  75                  80  


Val Arg Thr Thr Thr Gly Lys Thr Ile Thr Leu Glu Val Glu Pro Ser 
                85                  90                  95      


Asp Thr Ile Glu Asn Val Lys Ala Lys Ile Gln Asp Lys Glu Gly Ile 
            100                 105                 110         


Pro Pro Asp Gln Gln Arg Leu Ile Trp Ala Gly Lys Gln Leu Glu Asp 
        115                 120                 125             


Gly Arg Thr Leu Ser Asp Tyr Asn Ile Trp Pro Arg Arg Leu Leu His 
    130                 135                 140                 


Leu Val Leu Arg Leu Arg Ala Ala 
145                 150         


<210>  10
<211>  76
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  PDL1 binding protein Affilin211883

<400>  10

Met Gln Ile Phe Val Lys Thr Leu Thr Gly Lys Thr Ile Thr Leu Ala 
1               5                   10                  15      


Val Lys Pro Asn Asp Thr Ile Leu Lys Val Lys Val Trp Ile Glu Ile 
            20                  25                  30          


Lys Glu Gly Ile Pro Pro Asp Gln Gln Arg Leu Ile Trp Ala Gly Lys 
        35                  40                  45              


Gln Leu Glu Asp Gly Arg Thr Leu Ser Asp Tyr Asn Ile Gln Lys Glu 
    50                  55                  60                  


Ser Thr Leu His Leu Val Leu Arg Leu Arg Ala Ala 
65                  70                  75      


<210>  11
<211>  76
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  PDL-1 binding protein (monomer 1 of Affilin(r)211960)

<400>  11

Met Gln Ile Phe Val Gln Thr Asp Thr Gly Lys Thr Ile Thr Leu Glu 
1               5                   10                  15      


Val Glu Pro Ser Asp Thr Ile Glu Asn Val Lys Ala Lys Ile Gln Asp 
            20                  25                  30          


Lys Glu Gly Ile Pro Pro Asp Gln Gln Arg Leu Ile Trp Ala Gly Lys 
        35                  40                  45              


Gln Leu Glu Asp Gly Arg Thr Leu Ser Asp Tyr Asn Ile Gly Ile Val 
    50                  55                  60                  


Ala Pro Leu His Leu Val Leu Arg Leu Arg Ala Ala 
65                  70                  75      


<210>  12
<211>  76
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  PDL-1 binding protein (monomer 2 of Affilin(r)211960)

<400>  12

Met Gln Ile Phe Val Phe Thr Trp Thr Gly Lys Thr Ile Thr Leu Glu 
1               5                   10                  15      


Val Glu Pro Ser Asp Thr Ile Glu Asn Val Lys Ala Lys Ile Gln Asp 
            20                  25                  30          


Lys Glu Gly Ile Pro Pro Asp Gln Gln Arg Leu Ile Trp Ala Gly Lys 
        35                  40                  45              


Gln Leu Glu Asp Gly Arg Thr Leu Ser Asp Tyr Asn Ile Gly Asn Gly 
    50                  55                  60                  


Trp Met Leu His Leu Val Leu Arg Leu Arg Ala Ala 
65                  70                  75      


<210>  13
<211>  76
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  PDL-1 binding protein (monomer 1 of Affilin(r)211944)

<400>  13

Met Gln Ile Phe Val Phe Thr Ala Thr Gly Lys Thr Ile Thr Leu Glu 
1               5                   10                  15      


Val Glu Pro Ser Asp Thr Ile Glu Asn Val Lys Ala Lys Ile Gln Asp 
            20                  25                  30          


Lys Glu Gly Ile Pro Pro Asp Gln Gln Arg Leu Ile Trp Ala Gly Lys 
        35                  40                  45              


Gln Leu Glu Asp Gly Arg Thr Leu Ser Asp Tyr Asn Ile Arg Ser Gly 
    50                  55                  60                  


Trp Met Leu His Leu Val Leu Arg Leu Arg Ala Ala 
65                  70                  75      


<210>  14
<211>  76
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  PDL-1 binding protein (monomer 2 of Affilin(r)211944)

<400>  14

Met Gln Ile Phe Val Ala Thr Tyr Thr Gly Lys Thr Ile Thr Leu Glu 
1               5                   10                  15      


Val Glu Pro Ser Asp Thr Ile Glu Asn Val Lys Ala Lys Ile Gln Asp 
            20                  25                  30          


Lys Glu Gly Ile Pro Pro Asp Gln Gln Arg Leu Ile Trp Ala Gly Lys 
        35                  40                  45              


Gln Leu Glu Asp Gly Arg Thr Leu Ser Asp Tyr Asn Ile His Glu Pro 
    50                  55                  60                  


Glu Thr Leu His Leu Val Leu Arg Leu Arg Ala Ala 
65                  70                  75      


<210>  15
<211>  76
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  PDL-1 binding protein (monomer 1 of Affilin(r)211828)

<400>  15

Met Gln Ile Phe Val Asp Thr Leu Thr Gly Lys Thr Ile Thr Leu Glu 
1               5                   10                  15      


Val Glu Pro Ser Asp Thr Ile Glu Asn Val Lys Ala Lys Ile Gln Asp 
            20                  25                  30          


Lys Glu Gly Ile Pro Pro Asp Gln Gln Arg Leu Ile Trp Ala Gly Lys 
        35                  40                  45              


Gln Leu Glu Asp Gly Arg Thr Leu Ser Asp Tyr Asn Ile Arg Tyr Pro 
    50                  55                  60                  


Ala Phe Leu His Leu Val Leu Arg Leu Arg Ala Ala 
65                  70                  75      


<210>  16
<211>  76
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  PDL-1 binding protein (monomer 2 of Affilin(r)211828)

<400>  16

Met Gln Ile Phe Val Arg Thr Thr Thr Gly Lys Thr Ile Thr Leu Glu 
1               5                   10                  15      


Val Glu Pro Ser Asp Thr Ile Glu Asn Val Lys Ala Lys Ile Gln Asp 
            20                  25                  30          


Lys Glu Gly Ile Pro Pro Asp Gln Gln Arg Leu Ile Trp Ala Gly Lys 
        35                  40                  45              


Gln Leu Glu Asp Gly Arg Thr Leu Ser Asp Tyr Asn Ile Trp Pro Arg 
    50                  55                  60                  


Arg Leu Leu His Leu Val Leu Arg Leu Arg Ala Ala 
65                  70                  75      


<210>  17
<211>  248
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  PDL1 binding protein - fusion protein CID215194  (Affilin211883 
       fused to Affilin211828)

<400>  17

Met Gln Ile Phe Val Lys Thr Leu Thr Gly Lys Thr Ile Thr Leu Ala 
1               5                   10                  15      


Val Lys Pro Asn Asp Thr Ile Leu Lys Val Lys Val Trp Ile Glu Ile 
            20                  25                  30          


Lys Glu Gly Ile Pro Pro Asp Gln Gln Arg Leu Ile Trp Ala Gly Lys 
        35                  40                  45              


Gln Leu Glu Asp Gly Arg Thr Leu Ser Asp Tyr Asn Ile Gln Lys Glu 
    50                  55                  60                  


Ser Thr Leu His Leu Val Leu Arg Leu Arg Ala Ala Gly Gly Gly Gly 
65                  70                  75                  80  


Ser Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser 
                85                  90                  95      


Met Gln Ile Phe Val Asp Thr Leu Thr Gly Lys Thr Ile Thr Leu Glu 
            100                 105                 110         


Val Glu Pro Ser Asp Thr Ile Glu Asn Val Lys Ala Lys Ile Gln Asp 
        115                 120                 125             


Lys Glu Gly Ile Pro Pro Asp Gln Gln Arg Leu Ile Trp Ala Gly Lys 
    130                 135                 140                 


Gln Leu Glu Asp Gly Arg Thr Leu Ser Asp Tyr Asn Ile Arg Tyr Pro 
145                 150                 155                 160 


Ala Phe Leu His Leu Val Leu Arg Leu Arg Ala Ala Met Gln Ile Phe 
                165                 170                 175     


Val Arg Thr Thr Thr Gly Lys Thr Ile Thr Leu Glu Val Glu Pro Ser 
            180                 185                 190         


Asp Thr Ile Glu Asn Val Lys Ala Lys Ile Gln Asp Lys Glu Gly Ile 
        195                 200                 205             


Pro Pro Asp Gln Gln Arg Leu Ile Trp Ala Gly Lys Gln Leu Glu Asp 
    210                 215                 220                 


Gly Arg Thr Leu Ser Asp Tyr Asn Ile Trp Pro Arg Arg Leu Leu His 
225                 230                 235                 240 


Leu Val Leu Arg Leu Arg Ala Ala 
                245             


<210>  18
<211>  248
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  PDL1 binding protein - fusion protein CID215193  (Affilin211828 
       fused to Affilin211883)

<400>  18

Met Gln Ile Phe Val Asp Thr Leu Thr Gly Lys Thr Ile Thr Leu Glu 
1               5                   10                  15      


Val Glu Pro Ser Asp Thr Ile Glu Asn Val Lys Ala Lys Ile Gln Asp 
            20                  25                  30          


Lys Glu Gly Ile Pro Pro Asp Gln Gln Arg Leu Ile Trp Ala Gly Lys 
        35                  40                  45              


Gln Leu Glu Asp Gly Arg Thr Leu Ser Asp Tyr Asn Ile Arg Tyr Pro 
    50                  55                  60                  


Ala Phe Leu His Leu Val Leu Arg Leu Arg Ala Ala Met Gln Ile Phe 
65                  70                  75                  80  


Val Arg Thr Thr Thr Gly Lys Thr Ile Thr Leu Glu Val Glu Pro Ser 
                85                  90                  95      


Asp Thr Ile Glu Asn Val Lys Ala Lys Ile Gln Asp Lys Glu Gly Ile 
            100                 105                 110         


Pro Pro Asp Gln Gln Arg Leu Ile Trp Ala Gly Lys Gln Leu Glu Asp 
        115                 120                 125             


Gly Arg Thr Leu Ser Asp Tyr Asn Ile Trp Pro Arg Arg Leu Leu His 
    130                 135                 140                 


Leu Val Leu Arg Leu Arg Ala Ala Gly Gly Gly Gly Ser Gly Gly Gly 
145                 150                 155                 160 


Gly Ser Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser Met Gln Ile Phe 
                165                 170                 175     


Val Lys Thr Leu Thr Gly Lys Thr Ile Thr Leu Ala Val Lys Pro Asn 
            180                 185                 190         


Asp Thr Ile Leu Lys Val Lys Val Trp Ile Glu Ile Lys Glu Gly Ile 
        195                 200                 205             


Pro Pro Asp Gln Gln Arg Leu Ile Trp Ala Gly Lys Gln Leu Glu Asp 
    210                 215                 220                 


Gly Arg Thr Leu Ser Asp Tyr Asn Ile Gln Lys Glu Ser Thr Leu His 
225                 230                 235                 240 


Leu Val Leu Arg Leu Arg Ala Ala 
                245             


<210>  19
<211>  172
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  PDL1 binding protein - fusion protein CID215192  (Affilin211883 
       fused to Affilin211883)

<400>  19

Met Gln Ile Phe Val Lys Thr Leu Thr Gly Lys Thr Ile Thr Leu Ala 
1               5                   10                  15      


Val Lys Pro Asn Asp Thr Ile Leu Lys Val Lys Val Trp Ile Glu Ile 
            20                  25                  30          


Lys Glu Gly Ile Pro Pro Asp Gln Gln Arg Leu Ile Trp Ala Gly Lys 
        35                  40                  45              


Gln Leu Glu Asp Gly Arg Thr Leu Ser Asp Tyr Asn Ile Gln Lys Glu 
    50                  55                  60                  


Ser Thr Leu His Leu Val Leu Arg Leu Arg Ala Ala Gly Gly Gly Gly 
65                  70                  75                  80  


Ser Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser 
                85                  90                  95      


Met Gln Ile Phe Val Lys Thr Leu Thr Gly Lys Thr Ile Thr Leu Ala 
            100                 105                 110         


Val Lys Pro Asn Asp Thr Ile Leu Lys Val Lys Val Trp Ile Glu Ile 
        115                 120                 125             


Lys Glu Gly Ile Pro Pro Asp Gln Gln Arg Leu Ile Trp Ala Gly Lys 
    130                 135                 140                 


Gln Leu Glu Asp Gly Arg Thr Leu Ser Asp Tyr Asn Ile Gln Lys Glu 
145                 150                 155                 160 


Ser Thr Leu His Leu Val Leu Arg Leu Arg Ala Ala 
                165                 170         


<210>  20
<211>  324
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  PDL1 binding protein - fusion protein CID215191  (Affilin211828 
       fused to Affilin211828)

<400>  20

Met Gln Ile Phe Val Asp Thr Leu Thr Gly Lys Thr Ile Thr Leu Glu 
1               5                   10                  15      


Val Glu Pro Ser Asp Thr Ile Glu Asn Val Lys Ala Lys Ile Gln Asp 
            20                  25                  30          


Lys Glu Gly Ile Pro Pro Asp Gln Gln Arg Leu Ile Trp Ala Gly Lys 
        35                  40                  45              


Gln Leu Glu Asp Gly Arg Thr Leu Ser Asp Tyr Asn Ile Arg Tyr Pro 
    50                  55                  60                  


Ala Phe Leu His Leu Val Leu Arg Leu Arg Ala Ala Met Gln Ile Phe 
65                  70                  75                  80  


Val Arg Thr Thr Thr Gly Lys Thr Ile Thr Leu Glu Val Glu Pro Ser 
                85                  90                  95      


Asp Thr Ile Glu Asn Val Lys Ala Lys Ile Gln Asp Lys Glu Gly Ile 
            100                 105                 110         


Pro Pro Asp Gln Gln Arg Leu Ile Trp Ala Gly Lys Gln Leu Glu Asp 
        115                 120                 125             


Gly Arg Thr Leu Ser Asp Tyr Asn Ile Trp Pro Arg Arg Leu Leu His 
    130                 135                 140                 


Leu Val Leu Arg Leu Arg Ala Ala Gly Gly Gly Gly Ser Gly Gly Gly 
145                 150                 155                 160 


Gly Ser Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser Met Gln Ile Phe 
                165                 170                 175     


Val Asp Thr Leu Thr Gly Lys Thr Ile Thr Leu Glu Val Glu Pro Ser 
            180                 185                 190         


Asp Thr Ile Glu Asn Val Lys Ala Lys Ile Gln Asp Lys Glu Gly Ile 
        195                 200                 205             


Pro Pro Asp Gln Gln Arg Leu Ile Trp Ala Gly Lys Gln Leu Glu Asp 
    210                 215                 220                 


Gly Arg Thr Leu Ser Asp Tyr Asn Ile Arg Tyr Pro Ala Phe Leu His 
225                 230                 235                 240 


Leu Val Leu Arg Leu Arg Ala Ala Met Gln Ile Phe Val Arg Thr Thr 
                245                 250                 255     


Thr Gly Lys Thr Ile Thr Leu Glu Val Glu Pro Ser Asp Thr Ile Glu 
            260                 265                 270         


Asn Val Lys Ala Lys Ile Gln Asp Lys Glu Gly Ile Pro Pro Asp Gln 
        275                 280                 285             


Gln Arg Leu Ile Trp Ala Gly Lys Gln Leu Glu Asp Gly Arg Thr Leu 
    290                 295                 300                 


Ser Asp Tyr Asn Ile Trp Pro Arg Arg Leu Leu His Leu Val Leu Arg 
305                 310                 315                 320 


Leu Arg Ala Ala 
                


<210>  21
<211>  76
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  ubiquitin

<400>  21

Met Gln Ile Phe Val Lys Thr Leu Thr Gly Lys Thr Ile Thr Leu Glu 
1               5                   10                  15      


Val Glu Pro Ser Asp Thr Ile Glu Asn Val Lys Ala Lys Ile Gln Asp 
            20                  25                  30          


Lys Glu Gly Ile Pro Pro Asp Gln Gln Arg Leu Ile Phe Ala Gly Lys 
        35                  40                  45              


Gln Leu Glu Asp Gly Arg Thr Leu Ser Asp Tyr Asn Ile Gln Lys Glu 
    50                  55                  60                  


Ser Thr Leu His Leu Val Leu Arg Leu Arg Ala Ala 
65                  70                  75      


<210>  22
<211>  6
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  insert in position 9-10 of SEQ ID NO: 1

<400>  22

Glu Gln Ala Gln Glu His 
1               5       


<210>  23
<211>  6
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  insert of SEQ ID NO: 2 (between pos 9 and 10)

<400>  23

Phe Lys Ile Ile Pro Ala 
1               5       


<210>  24
<211>  4
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  insert of SEQ ID NO: 3 (insertion between pos. 9 / 10)

<400>  24

Val Leu Glu Met 
1               


<210>  25
<211>  4
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  insert of SEQ ID NO: 4 (insertion between pos 9/10)

<400>  25

Val Tyr Glu Val 
1               


<210>  26
<211>  220
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  ECR of human PD-L1

<400>  26

Phe Thr Val Thr Val Pro Lys Asp Leu Tyr Val Val Glu Tyr Gly Ser 
1               5                   10                  15      


Asn Met Thr Ile Glu Cys Lys Phe Pro Val Glu Lys Gln Leu Asp Leu 
            20                  25                  30          


Ala Ala Leu Ile Val Tyr Trp Glu Met Glu Asp Lys Asn Ile Ile Gln 
        35                  40                  45              


Phe Val His Gly Glu Glu Asp Leu Lys Val Gln His Ser Ser Tyr Arg 
    50                  55                  60                  


Gln Arg Ala Arg Leu Leu Lys Asp Gln Leu Ser Leu Gly Asn Ala Ala 
65                  70                  75                  80  


Leu Gln Ile Thr Asp Val Lys Leu Gln Asp Ala Gly Val Tyr Arg Cys 
                85                  90                  95      


Met Ile Ser Tyr Gly Gly Ala Asp Tyr Lys Arg Ile Thr Val Lys Val 
            100                 105                 110         


Asn Ala Pro Tyr Asn Lys Ile Asn Gln Arg Ile Leu Val Val Asp Pro 
        115                 120                 125             


Val Thr Ser Glu His Glu Leu Thr Cys Gln Ala Glu Gly Tyr Pro Lys 
    130                 135                 140                 


Ala Glu Val Ile Trp Thr Ser Ser Asp His Gln Val Leu Ser Gly Lys 
145                 150                 155                 160 


Thr Thr Thr Thr Asn Ser Lys Arg Glu Glu Lys Leu Phe Asn Val Thr 
                165                 170                 175     


Ser Thr Leu Arg Ile Asn Thr Thr Thr Asn Glu Ile Phe Tyr Cys Thr 
            180                 185                 190         


Phe Arg Arg Leu Asp Pro Glu Glu Asn His Thr Ala Glu Leu Val Ile 
        195                 200                 205             


Pro Glu Leu Pro Leu Ala His Pro Pro Asn Glu Arg 
    210                 215                 220 


