                         SEQUENCE LISTING

<110>  CENTRE NATIONAL DE LA RECHERCHE SCIENTIFIQUE (CNRS)
       Chalabi-Dchar, Mounira
 
<120>  COMBINATION THERAPY OF NUCANT AND mTOR INHIBITORS

<130>  50941PCT

<150>  US63/176647
<151>  2021-04-19

<160>  22    

<170>  PatentIn version 3.5

<210>  1
<211>  3
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic


<220>
<221>  MOD_RES
<222>  (2)..(2)
<223>  Aib

<400>  1

Lys Xaa Gly 
1           


<210>  2
<211>  4
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic


<220>
<221>  MOD_RES
<222>  (1)..(1)
<223>  Aib

<220>
<221>  MOD_RES
<222>  (3)..(3)
<223>  Aib

<400>  2

Xaa Lys Xaa Gly 
1               


<210>  3
<211>  5
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic


<220>
<221>  MOD_RES
<222>  (1)..(1)
<223>  absent or an amino acid

<220>
<221>  MOD_RES
<222>  (2)..(3)
<223>  a reduced bond (-CH2NH-), a retro-inverso bond (-NHCO-), a 
       methyleneoxy bond (-CH2O-), a thiomethylene bond (-CH2-S-), a 
       carba bond (-CH2CH2-), a ketomethylene bond (-CO-CH2-), a 
       hydroxyethylene bond (-CHOH-CH2-), an E-alkylene bond , or a C=C 
       

<220>
<221>  MOD_RES
<222>  (2)..(2)
<223>  a basic amino acid

<220>
<221>  MOD_RES
<222>  (3)..(3)
<223>  a proline or derivative thereof

<220>
<221>  MOD_RES
<222>  (4)..(4)
<223>  a basic amino acid

<220>
<221>  MOD_RES
<222>  (5)..(5)
<223>  zero to three amino acids

<400>  3

Xaa Xaa Xaa Xaa Xaa 
1               5   


<210>  4
<211>  5
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic


<220>
<221>  MOD_RES
<222>  (1)..(1)
<223>  absent or 1 amino acid

<220>
<221>  MOD_RES
<222>  (2)..(3)
<223>  a reduced bond (-CH2NH-), a retro-inverso bond (-NHCO-), a 
       methyleneoxy bond (-CH2O-), a thiomethylene bond (-CH2-S-), a 
       carba bond (-CH2CH2-), a ketomethylene bond (-CO-CH2-), a 
       hydroxyethylene bond (-CHOH-CH2-), an E-alkylene bond , or a C=C 
       

<220>
<221>  MOD_RES
<222>  (2)..(2)
<223>  a basic amino acid

<220>
<221>  MOD_RES
<222>  (4)..(4)
<223>  a basic amino acid

<220>
<221>  MOD_RES
<222>  (5)..(5)
<223>  zero to 3 amino acids

<400>  4

Xaa Xaa Pro Xaa Xaa 
1               5   


<210>  5
<211>  63
<212>  PRT
<213>  Homo sapiens

<400>  5

Lys Gly Glu Gly Gly Phe Gly Gly Arg Gly Gly Gly Arg Gly Gly Phe 
1               5                   10                  15      


Gly Gly Arg Gly Gly Gly Arg Gly Gly Arg Gly Gly Phe Gly Gly Arg 
            20                  25                  30          


Gly Arg Gly Gly Arg Gly Gly Arg Gly Gly Phe Arg Gly Gly Arg Gly 
        35                  40                  45              


Gly Gly Gly Asp His Lys Pro Gln Gly Lys Lys Thr Lys Phe Glu 
    50                  55                  60              


<210>  6
<211>  18
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic


<220>
<221>  MOD_RES
<222>  (1)..(1)
<223>  ACETYLATION

<220>
<221>  MISC_FEATURE
<222>  (1)..(1)
<223>  Lys-CH2NH-Pro-Arg-

<220>
<221>  misc_feature
<222>  (2)..(2)
<223>  Xaa can be any naturally occurring amino acid

<220>
<221>  MISC_FEATURE
<222>  (4)..(4)
<223>  Lys-CH2NH-Pro-Arg-

<220>
<221>  misc_feature
<222>  (5)..(5)
<223>  Xaa can be any naturally occurring amino acid

<220>
<221>  MISC_FEATURE
<222>  (7)..(7)
<223>  Lys-CH2NH-Pro-Arg-

<220>
<221>  misc_feature
<222>  (8)..(8)
<223>  Xaa can be any naturally occurring amino acid

<220>
<221>  MISC_FEATURE
<222>  (10)..(10)
<223>  Lys-CH2NH-Pro-Arg-

<220>
<221>  misc_feature
<222>  (11)..(11)
<223>  Xaa can be any naturally occurring amino acid

<220>
<221>  MISC_FEATURE
<222>  (13)..(13)
<223>  Lys-CH2NH-Pro-Arg-

<220>
<221>  misc_feature
<222>  (14)..(14)
<223>  Xaa can be any naturally occurring amino acid

<220>
<221>  MISC_FEATURE
<222>  (16)..(16)
<223>  Lys-CH2NH-Pro-Arg-

<220>
<221>  misc_feature
<222>  (17)..(17)
<223>  Xaa can be any naturally occurring amino acid

<220>
<221>  MOD_RES
<222>  (18)..(18)
<223>  AMIDATION

<400>  6

Lys Xaa Gly Lys Xaa Gly Lys Xaa Gly Lys Xaa Gly Lys Xaa Gly Lys 
1               5                   10                  15      


Xaa Gly 
        


<210>  7
<211>  10
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic

<400>  7

Lys Lys Lys Gly Pro Lys Glu Lys Gly Cys 
1               5                   10  


<210>  8
<211>  6
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic

<400>  8

Lys Lys Lys Lys Gly Cys 
1               5       


<210>  9
<211>  12
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic

<400>  9

Lys Lys Lys Lys Gly Pro Lys Lys Lys Lys Gly Ala 
1               5                   10          


<210>  10
<211>  9
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic


<220>
<221>  MOD_RES
<222>  (9)..(9)
<223>  (2S)-2-aminohexanamide

<400>  10

Lys Lys Lys Gly Pro Lys Glu Lys Xaa 
1               5                   


<210>  11
<211>  5
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic

<400>  11

Lys Ala Lys Pro Gly 
1               5   


<210>  12
<211>  15
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic


<220>
<221>  MOD_RES
<222>  (1)..(1)
<223>  ACETYLATION

<220>
<221>  MOD_RES
<222>  (15)..(15)
<223>  AMIDATION

<400>  12

Lys Ala Lys Pro Gly Lys Ala Lys Pro Gly Lys Ala Lys Pro Gly 
1               5                   10                  15  


<210>  13
<211>  12
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic


<220>
<221>  MOD_RES
<222>  (1)..(1)
<223>  ACETYLATION

<220>
<221>  MOD_RES
<222>  (2)..(2)
<223>  Aib

<220>
<221>  MOD_RES
<222>  (5)..(5)
<223>  Aib

<220>
<221>  MOD_RES
<222>  (8)..(8)
<223>  Aib

<220>
<221>  MOD_RES
<222>  (11)..(11)
<223>  Aib

<220>
<221>  MOD_RES
<222>  (12)..(12)
<223>  AMIDATION

<400>  13

Lys Xaa Gly Lys Xaa Gly Lys Xaa Gly Lys Xaa Gly 
1               5                   10          


<210>  14
<211>  20
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic


<220>
<221>  MOD_RES
<222>  (1)..(1)
<223>  Aib

<220>
<221>  MOD_RES
<222>  (3)..(3)
<223>  Aib

<220>
<221>  MOD_RES
<222>  (5)..(5)
<223>  Aib

<220>
<221>  MOD_RES
<222>  (7)..(7)
<223>  Aib

<220>
<221>  MOD_RES
<222>  (9)..(9)
<223>  Aib

<220>
<221>  MOD_RES
<222>  (11)..(11)
<223>  Aib

<220>
<221>  MOD_RES
<222>  (13)..(13)
<223>  Aib

<220>
<221>  MOD_RES
<222>  (15)..(15)
<223>  Aib

<220>
<221>  MOD_RES
<222>  (17)..(17)
<223>  Aib

<220>
<221>  MOD_RES
<222>  (19)..(19)
<223>  Aib

<400>  14

Xaa Leu Xaa Gly Xaa Leu Xaa Gly Xaa Leu Xaa Gly Xaa Leu Xaa Gly 
1               5                   10                  15      


Xaa Leu Xaa Gly 
            20  


<210>  15
<211>  15
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic


<220>
<221>  MOD_RES
<222>  (2)..(2)
<223>  Aib

<220>
<221>  MOD_RES
<222>  (5)..(5)
<223>  Aib

<220>
<221>  MOD_RES
<222>  (8)..(8)
<223>  Aib

<220>
<221>  MOD_RES
<222>  (11)..(11)
<223>  Aib

<220>
<221>  MOD_RES
<222>  (14)..(14)
<223>  Aib

<400>  15

Lys Xaa Gly Lys Xaa Gly Lys Xaa Gly Lys Xaa Gly Lys Xaa Gly 
1               5                   10                  15  


<210>  16
<211>  20
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic


<220>
<221>  MOD_RES
<222>  (1)..(1)
<223>  Aib

<220>
<221>  MOD_RES
<222>  (1)..(1)
<223>  ACETYLATION

<220>
<221>  MOD_RES
<222>  (3)..(3)
<223>  Aib

<220>
<221>  MOD_RES
<222>  (5)..(5)
<223>  Aib

<220>
<221>  MOD_RES
<222>  (7)..(7)
<223>  Aib

<220>
<221>  MOD_RES
<222>  (9)..(9)
<223>  Aib

<220>
<221>  MOD_RES
<222>  (11)..(11)
<223>  Aib

<220>
<221>  MOD_RES
<222>  (13)..(13)
<223>  Aib

<220>
<221>  MOD_RES
<222>  (15)..(15)
<223>  Aib

<220>
<221>  MOD_RES
<222>  (17)..(17)
<223>  Aib

<220>
<221>  MOD_RES
<222>  (19)..(19)
<223>  Aib

<220>
<221>  MOD_RES
<222>  (20)..(20)
<223>  AMIDATION

<400>  16

Xaa Lys Xaa Gly Xaa Lys Xaa Gly Xaa Lys Xaa Gly Xaa Lys Xaa Gly 
1               5                   10                  15      


Xaa Lys Xaa Gly 
            20  


<210>  17
<211>  15
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic


<220>
<221>  MOD_RES
<222>  (1)..(1)
<223>  ACETYLATION

<220>
<221>  MOD_RES
<222>  (2)..(2)
<223>  Aib

<220>
<221>  MOD_RES
<222>  (5)..(5)
<223>  Aib

<220>
<221>  MOD_RES
<222>  (8)..(8)
<223>  Aib

<220>
<221>  MOD_RES
<222>  (11)..(11)
<223>  Aib

<220>
<221>  MOD_RES
<222>  (14)..(14)
<223>  Aib

<220>
<221>  MOD_RES
<222>  (15)..(15)
<223>  AMIDATION

<400>  17

Lys Xaa Gly Lys Xaa Gly Lys Xaa Gly Lys Xaa Gly Lys Xaa Gly 
1               5                   10                  15  


<210>  18
<211>  24
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic


<220>
<221>  MOD_RES
<222>  (1)..(1)
<223>  ACETYLATION

<220>
<221>  MOD_RES
<222>  (1)..(1)
<223>  Aib

<220>
<221>  MOD_RES
<222>  (3)..(3)
<223>  Aib

<220>
<221>  MOD_RES
<222>  (5)..(5)
<223>  Aib

<220>
<221>  MOD_RES
<222>  (7)..(7)
<223>  Aib

<220>
<221>  MOD_RES
<222>  (9)..(9)
<223>  Aib

<220>
<221>  MOD_RES
<222>  (11)..(11)
<223>  Aib

<220>
<221>  MOD_RES
<222>  (13)..(13)
<223>  Aib

<220>
<221>  MOD_RES
<222>  (15)..(15)
<223>  Aib

<220>
<221>  MOD_RES
<222>  (17)..(17)
<223>  Aib

<220>
<221>  MOD_RES
<222>  (19)..(19)
<223>  Aib

<220>
<221>  MOD_RES
<222>  (21)..(21)
<223>  Aib

<220>
<221>  MOD_RES
<222>  (23)..(23)
<223>  Aib

<220>
<221>  MOD_RES
<222>  (24)..(24)
<223>  AMIDATION

<400>  18

Xaa Lys Xaa Gly Xaa Lys Xaa Gly Xaa Lys Xaa Gly Xaa Lys Xaa Gly 
1               5                   10                  15      


Xaa Lys Xaa Gly Xaa Lys Xaa Gly 
            20                  


<210>  19
<211>  18
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic


<220>
<221>  MOD_RES
<222>  (1)..(1)
<223>  ACETYLATION

<220>
<221>  MOD_RES
<222>  (2)..(2)
<223>  Aib

<220>
<221>  MOD_RES
<222>  (5)..(5)
<223>  Aib

<220>
<221>  MOD_RES
<222>  (8)..(8)
<223>  Aib

<220>
<221>  MOD_RES
<222>  (11)..(11)
<223>  Aib

<220>
<221>  MOD_RES
<222>  (14)..(14)
<223>  Aib

<220>
<221>  MOD_RES
<222>  (17)..(17)
<223>  Aib

<220>
<221>  MOD_RES
<222>  (18)..(18)
<223>  AMIDATION

<400>  19

Lys Xaa Gly Lys Xaa Gly Lys Xaa Gly Lys Xaa Gly Lys Xaa Gly Lys 
1               5                   10                  15      


Xaa Gly 
        


<210>  20
<211>  24
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic


<220>
<221>  MOD_RES
<222>  (1)..(1)
<223>  ACETYLATION

<220>
<221>  MOD_RES
<222>  (2)..(2)
<223>  Aib

<220>
<221>  MOD_RES
<222>  (5)..(5)
<223>  Aib

<220>
<221>  MOD_RES
<222>  (8)..(8)
<223>  Aib

<220>
<221>  MOD_RES
<222>  (11)..(11)
<223>  Aib

<220>
<221>  MOD_RES
<222>  (14)..(14)
<223>  Aib

<220>
<221>  MOD_RES
<222>  (17)..(17)
<223>  Aib

<220>
<221>  MOD_RES
<222>  (20)..(20)
<223>  Aib

<220>
<221>  MOD_RES
<222>  (23)..(23)
<223>  Aib

<220>
<221>  MOD_RES
<222>  (24)..(24)
<223>  AMIDATION

<400>  20

Lys Xaa Gly Lys Xaa Gly Lys Xaa Gly Lys Xaa Gly Lys Xaa Gly Lys 
1               5                   10                  15      


Xaa Gly Lys Xaa Gly Lys Ser Gly 
            20                  


<210>  21
<211>  21
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Synthetic

<400>  21
uucuuugaca ggcucuuccu u                                                 21


<210>  22
<211>  21
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Synthetic

<400>  22
uccaagguaa cuuuauuucu u                                                 21


