                         SEQUENCE LISTING

<110>  NOVO NORDISK A/S
	Dicerna Pharmaceuticals, Inc.
       
 
<120>  COMPOSITIONS AND METHODS FOR INHIBITING NUCLEAR RECEPTOR SUBFAMILY 1 GROUP H MEMBER 3 (NR1H3) EXPRESSION

<130>  210010WO01

<140> Not Yet Assigned
<141> Filed Concurrently Herewith

<150> EP 21 213 711.1
<151> 2021-12-10

<150> EP 21 1863 66.7
<151> 2021-07-19

<150> US 63/176,814
<151> 2021-04-19

<160>  1552  

<170>  PatentIn version 3.5

<210>  1
<211>  25
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  25 mer sense strand

<400>  1
uguccuguca gaagaacaga uccgc                                             25


<210>  2
<211>  25
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  25 mer sense strand

<400>  2
uccugucaga agaacagaua cgccu                                             25


<210>  3
<211>  25
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  25 mer sense strand

<400>  3
cugaagaaac ugaagcggca agagg                                             25


<210>  4
<211>  25
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  25 mer sense strand

<400>  4
ugaagaaacu gaagcggcaa gagga                                             25


<210>  5
<211>  25
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  25 mer sense strand

<400>  5
gaagaaacug aagcggcaaa aggag                                             25


<210>  6
<211>  25
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  25 mer sense strand

<400>  6
aagaaacuga agcggcaaga ggagg                                             25


<210>  7
<211>  25
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  25 mer sense strand

<400>  7
agaaacugaa gcggcaagaa gagga                                             25


<210>  8
<211>  25
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  25 mer sense strand

<400>  8
aaacugaagc ggcaagagga ggaac                                             25


<210>  9
<211>  25
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  25 mer sense strand

<400>  9
aacugaagcg gcaagaggaa gaaca                                             25


<210>  10
<211>  25
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  25 mer sense strand

<400>  10
acugaagcgg caagaggaga aacag                                             25


<210>  11
<211>  25
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  25 mer sense strand

<400>  11
cugaagcggc aagaggagga acagg                                             25


<210>  12
<211>  25
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  25 mer sense strand

<400>  12
ugaagcggca agaggaggaa caggc                                             25


<210>  13
<211>  25
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  25 mer sense strand

<400>  13
agcggcaaga ggaggaacaa gcuca                                             25


<210>  14
<211>  25
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  25 mer sense strand

<400>  14
gcggcaagag gaggaacaga cucau                                             25


<210>  15
<211>  25
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  25 mer sense strand

<400>  15
cggcaagagg aggaacagga ucaug                                             25


<210>  16
<211>  25
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  25 mer sense strand

<400>  16
gcaagaggag gaacaggcua augcc                                             25


<210>  17
<211>  25
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  25 mer sense strand

<400>  17
aagaggagga acaggcucaa gccac                                             25


<210>  18
<211>  25
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  25 mer sense strand

<400>  18
agaggaggaa caggcucaua ccaca                                             25


<210>  19
<211>  25
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  25 mer sense strand

<400>  19
gaggaggaac aggcucauga cacau                                             25


<210>  20
<211>  25
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  25 mer sense strand

<400>  20
aggaggaaca ggcucaugca acauc                                             25


<210>  21
<211>  25
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  25 mer sense strand

<400>  21
gaggaacagg cucaugccaa auccu                                             25


<210>  22
<211>  25
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  25 mer sense strand

<400>  22
ccagggcuuc cucaccccca caaau                                             25


<210>  23
<211>  25
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  25 mer sense strand

<400>  23
ugggcaugau cgagaagcua gucgc                                             25


<210>  24
<211>  25
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  25 mer sense strand

<400>  24
gcaugaucga gaagcucgua gcugc                                             25


<210>  25
<211>  25
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  25 mer sense strand

<400>  25
gucgcugccc agcaacagua uaacc                                             25


<210>  26
<211>  25
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  25 mer sense strand

<400>  26
cgcugcccag caacagugua accgg                                             25


<210>  27
<211>  25
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  25 mer sense strand

<400>  27
cccagcaaca guguaaccga cgcuc                                             25


<210>  28
<211>  25
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  25 mer sense strand

<400>  28
cagcaacagu guaaccggca cuccu                                             25


<210>  29
<211>  25
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  25 mer sense strand

<400>  29
agcaacagug uaaccggcga uccuu                                             25


<210>  30
<211>  25
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  25 mer sense strand

<400>  30
caacagugua accggcgcua cuuuu                                             25


<210>  31
<211>  25
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  25 mer sense strand

<400>  31
aacaguguaa ccggcgcuca uuuuc                                             25


<210>  32
<211>  25
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  25 mer sense strand

<400>  32
acaguguaac cggcgcucca uuucu                                             25


<210>  33
<211>  25
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  25 mer sense strand

<400>  33
caguguaacc ggcgcuccua uucug                                             25


<210>  34
<211>  25
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  25 mer sense strand

<400>  34
aguguaaccg gcgcuccuua ucuga                                             25


<210>  35
<211>  25
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  25 mer sense strand

<400>  35
guguaaccgg cgcuccuuua cugac                                             25


<210>  36
<211>  25
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  25 mer sense strand

<400>  36
uguaaccggc gcuccuuuua ugacc                                             25


<210>  37
<211>  25
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  25 mer sense strand

<400>  37
gcgcuccuuu ucugaccgga uucga                                             25


<210>  38
<211>  25
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  25 mer sense strand

<400>  38
cuccuuuucu gaccggcuua gaguc                                             25


<210>  39
<211>  25
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  25 mer sense strand

<400>  39
uccuuuucug accggcuuca aguca                                             25


<210>  40
<211>  25
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  25 mer sense strand

<400>  40
ccuuuucuga ccggcuucga gucac                                             25


<210>  41
<211>  25
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  25 mer sense strand

<400>  41
cuuuucugac cggcuucgaa ucacg                                             25


<210>  42
<211>  25
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  25 mer sense strand

<400>  42
uuucugaccg gcuucgagua acgcc                                             25


<210>  43
<211>  25
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  25 mer sense strand

<400>  43
ucugaccggc uucgagucaa gccuu                                             25


<210>  44
<211>  25
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  25 mer sense strand

<400>  44
cugaccggcu ucgagucaca ccuug                                             25


<210>  45
<211>  25
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  25 mer sense strand

<400>  45
ugaccggcuu cgagucacga cuugg                                             25


<210>  46
<211>  25
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  25 mer sense strand

<400>  46
ggugaugcuu cuggagacaa cucgg                                             25


<210>  47
<211>  25
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  25 mer sense strand

<400>  47
ugaugcuucu ggagacauca cggag                                             25


<210>  48
<211>  25
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  25 mer sense strand

<400>  48
gaugcuucug gagacaucua ggagg                                             25


<210>  49
<211>  25
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  25 mer sense strand

<400>  49
augcuucugg agacaucuca gaggu                                             25


<210>  50
<211>  25
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  25 mer sense strand

<400>  50
ugcuucugga gacaucucga aggua                                             25


<210>  51
<211>  25
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  25 mer sense strand

<400>  51
gcuucuggag acaucucgga gguac                                             25


<210>  52
<211>  25
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  25 mer sense strand

<400>  52
cuucuggaga caucucggaa guaca                                             25


<210>  53
<211>  25
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  25 mer sense strand

<400>  53
uucuggagac aucucggaga uacaa                                             25


<210>  54
<211>  25
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  25 mer sense strand

<400>  54
ucuggagaca ucucggagga acaac                                             25


<210>  55
<211>  25
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  25 mer sense strand

<400>  55
cuggagacau cucggaggua caacc                                             25


<210>  56
<211>  25
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  25 mer sense strand

<400>  56
uggagacauc ucggagguaa aaccc                                             25


<210>  57
<211>  25
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  25 mer sense strand

<400>  57
ggagacaucu cggagguaca acccu                                             25


<210>  58
<211>  25
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  25 mer sense strand

<400>  58
gagacaucuc ggagguacaa cccug                                             25


<210>  59
<211>  25
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  25 mer sense strand

<400>  59
agacaucucg gagguacaaa ccugg                                             25


<210>  60
<211>  25
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  25 mer sense strand

<400>  60
gacaucucgg agguacaaca cuggg                                             25


<210>  61
<211>  25
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  25 mer sense strand

<400>  61
acaucucgga gguacaacca uggga                                             25


<210>  62
<211>  25
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  25 mer sense strand

<400>  62
aucucggagg uacaacccua ggagu                                             25


<210>  63
<211>  25
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  25 mer sense strand

<400>  63
ucucggaggu acaacccuga gagug                                             25


<210>  64
<211>  25
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  25 mer sense strand

<400>  64
cucggaggua caacccugga aguga                                             25


<210>  65
<211>  25
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  25 mer sense strand

<400>  65
cggagguaca acccugggaa ugaga                                             25


<210>  66
<211>  25
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  25 mer sense strand

<400>  66
gagguacaac ccugggagua agagu                                             25


<210>  67
<211>  25
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  25 mer sense strand

<400>  67
agguacaacc cugggaguga gagua                                             25


<210>  68
<211>  25
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  25 mer sense strand

<400>  68
gguacaaccc ugggagugaa aguau                                             25


<210>  69
<211>  25
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  25 mer sense strand

<400>  69
guacaacccu gggagugaga guauc                                             25


<210>  70
<211>  25
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  25 mer sense strand

<400>  70
uacaacccug ggagugagaa uauca                                             25


<210>  71
<211>  25
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  25 mer sense strand

<400>  71
acaacccugg gagugagaga aucac                                             25


<210>  72
<211>  25
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  25 mer sense strand

<400>  72
caacccuggg agugagagua ucacc                                             25


<210>  73
<211>  25
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  25 mer sense strand

<400>  73
aacccuggga gugagaguaa caccu                                             25


<210>  74
<211>  25
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  25 mer sense strand

<400>  74
acccugggag ugagaguaua accuu                                             25


<210>  75
<211>  25
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  25 mer sense strand

<400>  75
cccugggagu gagaguauca ccuuc                                             25


<210>  76
<211>  25
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  25 mer sense strand

<400>  76
ccugggagug agaguaucaa cuucc                                             25


<210>  77
<211>  25
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  25 mer sense strand

<400>  77
cugggaguga gaguaucaca uuccu                                             25


<210>  78
<211>  25
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  25 mer sense strand

<400>  78
ugggagugag aguaucacca uccuc                                             25


<210>  79
<211>  25
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  25 mer sense strand

<400>  79
gggagugaga guaucaccua ccuca                                             25


<210>  80
<211>  25
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  25 mer sense strand

<400>  80
gagugagagu aucaccuuca ucaag                                             25


<210>  81
<211>  25
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  25 mer sense strand

<400>  81
agugagagua ucaccuucca caagg                                             25


<210>  82
<211>  25
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  25 mer sense strand

<400>  82
gugagaguau caccuuccua aagga                                             25


<210>  83
<211>  25
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  25 mer sense strand

<400>  83
ugagaguauc accuuccuca aggau                                             25


<210>  84
<211>  25
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  25 mer sense strand

<400>  84
gagaguauca ccuuccucaa ggauu                                             25


<210>  85
<211>  25
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  25 mer sense strand

<400>  85
gaguaucacc uuccucaaga auuuc                                             25


<210>  86
<211>  25
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  25 mer sense strand

<400>  86
aguaucaccu uccucaagga uuuca                                             25


<210>  87
<211>  25
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  25 mer sense strand

<400>  87
guaucaccuu ccucaaggaa uucag                                             25


<210>  88
<211>  25
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  25 mer sense strand

<400>  88
uaucaccuuc cucaaggaua ucagu                                             25


<210>  89
<211>  25
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  25 mer sense strand

<400>  89
aucaccuucc ucaaggauua caguu                                             25


<210>  90
<211>  25
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  25 mer sense strand

<400>  90
accuuccuca aggauuucaa uuaua                                             25


<210>  91
<211>  25
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  25 mer sense strand

<400>  91
ccuuccucaa ggauuucaga uauaa                                             25


<210>  92
<211>  25
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  25 mer sense strand

<400>  92
uccucaagga uuucaguuaa aaccg                                             25


<210>  93
<211>  25
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  25 mer sense strand

<400>  93
caaggauuuc aguuauaaca gggaa                                             25


<210>  94
<211>  25
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  25 mer sense strand

<400>  94
aaggauuuca guuauaacca ggaag                                             25


<210>  95
<211>  25
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  25 mer sense strand

<400>  95
aggauuucag uuauaaccga gaaga                                             25


<210>  96
<211>  25
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  25 mer sense strand

<400>  96
ggauuucagu uauaaccgga aagac                                             25


<210>  97
<211>  25
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  25 mer sense strand

<400>  97
gauuucaguu auaaccggga agacu                                             25


<210>  98
<211>  25
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  25 mer sense strand

<400>  98
auuucaguua uaaccgggaa gacuu                                             25


<210>  99
<211>  25
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  25 mer sense strand

<400>  99
uuucaguuau aaccgggaaa acuuu                                             25


<210>  100
<211>  25
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  25 mer sense strand

<400>  100
uucaguuaua accgggaaga cuuug                                             25


<210>  101
<211>  25
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  25 mer sense strand

<400>  101
ucaguuauaa ccgggaagaa uuugc                                             25


<210>  102
<211>  25
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  25 mer sense strand

<400>  102
caguuauaac cgggaagaca uugcc                                             25


<210>  103
<211>  25
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  25 mer sense strand

<400>  103
guuauaaccg ggaagacuua gccaa                                             25


<210>  104
<211>  25
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  25 mer sense strand

<400>  104
uuauaaccgg gaagacuuua ccaaa                                             25


<210>  105
<211>  25
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  25 mer sense strand

<400>  105
uauaaccggg aagacuuuga caaag                                             25


<210>  106
<211>  25
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  25 mer sense strand

<400>  106
auaaccggga agacuuugca aaagc                                             25


<210>  107
<211>  25
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  25 mer sense strand

<400>  107
uaaccgggaa gacuuugcca aagca                                             25


<210>  108
<211>  25
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  25 mer sense strand

<400>  108
aaccgggaag acuuugccaa agcag                                             25


<210>  109
<211>  25
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  25 mer sense strand

<400>  109
accgggaaga cuuugccaaa gcagg                                             25


<210>  110
<211>  25
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  25 mer sense strand

<400>  110
ccgggaagac uuugccaaaa caggg                                             25


<210>  111
<211>  25
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  25 mer sense strand

<400>  111
ggaagacuuu gccaaagcaa ggcug                                             25


<210>  112
<211>  25
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  25 mer sense strand

<400>  112
gaagacuuug ccaaagcaga gcugc                                             25


<210>  113
<211>  25
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  25 mer sense strand

<400>  113
aagacuuugc caaagcagga cugca                                             25


<210>  114
<211>  25
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  25 mer sense strand

<400>  114
agacuuugcc aaagcaggga ugcaa                                             25


<210>  115
<211>  25
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  25 mer sense strand

<400>  115
gacuuugcca aagcagggca gcaag                                             25


<210>  116
<211>  25
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  25 mer sense strand

<400>  116
acuuugccaa agcagggcua caagu                                             25


<210>  117
<211>  25
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  25 mer sense strand

<400>  117
cuuugccaaa gcagggcuga aagug                                             25


<210>  118
<211>  25
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  25 mer sense strand

<400>  118
ugccaaagca gggcugcaaa uggaa                                             25


<210>  119
<211>  25
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  25 mer sense strand

<400>  119
gccaaagcag ggcugcaaga ggaau                                             25


<210>  120
<211>  25
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  25 mer sense strand

<400>  120
ccaaagcagg gcugcaagua gaauu                                             25


<210>  121
<211>  25
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  25 mer sense strand

<400>  121
caaagcaggg cugcaaguga aauuc                                             25


<210>  122
<211>  25
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  25 mer sense strand

<400>  122
aaagcagggc ugcaagugga auuca                                             25


<210>  123
<211>  25
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  25 mer sense strand

<400>  123
aagcagggcu gcaaguggaa uucau                                             25


<210>  124
<211>  25
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  25 mer sense strand

<400>  124
agcagggcug caaguggaaa ucauc                                             25


<210>  125
<211>  25
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  25 mer sense strand

<400>  125
gcagggcugc aaguggaaua cauca                                             25


<210>  126
<211>  25
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  25 mer sense strand

<400>  126
agggcugcaa guggaauuca ucaac                                             25


<210>  127
<211>  25
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  25 mer sense strand

<400>  127
gggcugcaag uggaauucaa caacc                                             25


<210>  128
<211>  25
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  25 mer sense strand

<400>  128
ggcugcaagu ggaauucaua aaccc                                             25


<210>  129
<211>  25
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  25 mer sense strand

<400>  129
gcugcaagug gaauucauca acccc                                             25


<210>  130
<211>  25
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  25 mer sense strand

<400>  130
gcaaguggaa uucaucaaca ccauc                                             25


<210>  131
<211>  25
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  25 mer sense strand

<400>  131
aaguggaauu caucaaccca aucuu                                             25


<210>  132
<211>  25
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  25 mer sense strand

<400>  132
aguggaauuc aucaacccca ucuuc                                             25


<210>  133
<211>  25
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  25 mer sense strand

<400>  133
uggaauucau caaccccaua uucga                                             25


<210>  134
<211>  25
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  25 mer sense strand

<400>  134
ggaauucauc aaccccauca ucgag                                             25


<210>  135
<211>  25
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  25 mer sense strand

<400>  135
auucaucaac cccaucuuca aguuc                                             25


<210>  136
<211>  25
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  25 mer sense strand

<400>  136
uucaucaacc ccaucuucga guucu                                             25


<210>  137
<211>  25
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  25 mer sense strand

<400>  137
ucaucaaccc caucuucgaa uucuc                                             25


<210>  138
<211>  25
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  25 mer sense strand

<400>  138
caucaacccc aucuucgaga ucucc                                             25


<210>  139
<211>  25
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  25 mer sense strand

<400>  139
aucaacccca ucuucgagua cucca                                             25


<210>  140
<211>  25
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  25 mer sense strand

<400>  140
ucaaccccau cuucgaguua uccag                                             25


<210>  141
<211>  25
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  25 mer sense strand

<400>  141
caaccccauc uucgaguuca ccagg                                             25


<210>  142
<211>  25
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  25 mer sense strand

<400>  142
aaccccaucu ucgaguucua caggg                                             25


<210>  143
<211>  25
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  25 mer sense strand

<400>  143
accccaucuu cgaguucuca agggc                                             25


<210>  144
<211>  25
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  25 mer sense strand

<400>  144
cccaucuucg aguucuccaa ggcca                                             25


<210>  145
<211>  25
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  25 mer sense strand

<400>  145
ccaucuucga guucuccaga gccau                                             25


<210>  146
<211>  25
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  25 mer sense strand

<400>  146
caucuucgag uucuccagga ccaug                                             25


<210>  147
<211>  25
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  25 mer sense strand

<400>  147
aucuucgagu ucuccaggga cauga                                             25


<210>  148
<211>  25
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  25 mer sense strand

<400>  148
ucuucgaguu cuccagggca augaa                                             25


<210>  149
<211>  25
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  25 mer sense strand

<400>  149
cuucgaguuc uccagggcca ugaau                                             25


<210>  150
<211>  25
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  25 mer sense strand

<400>  150
uucgaguucu ccagggccaa gaaug                                             25


<210>  151
<211>  25
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  25 mer sense strand

<400>  151
ucgaguucuc cagggccaua aauga                                             25


<210>  152
<211>  25
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  25 mer sense strand

<400>  152
cgaguucucc agggccauga augag                                             25


<210>  153
<211>  25
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  25 mer sense strand

<400>  153
gaguucucca gggccaugaa ugagc                                             25


<210>  154
<211>  25
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  25 mer sense strand

<400>  154
aguucuccag ggccaugaaa gagcu                                             25


<210>  155
<211>  25
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  25 mer sense strand

<400>  155
guucuccagg gccaugaaua agcug                                             25


<210>  156
<211>  25
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  25 mer sense strand

<400>  156
ucuccagggc caugaaugaa cugca                                             25


<210>  157
<211>  25
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  25 mer sense strand

<400>  157
cuccagggcc augaaugaga ugcaa                                             25


<210>  158
<211>  25
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  25 mer sense strand

<400>  158
uccagggcca ugaaugagca gcaac                                             25


<210>  159
<211>  25
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  25 mer sense strand

<400>  159
ccagggccau gaaugagcua caacu                                             25


<210>  160
<211>  25
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  25 mer sense strand

<400>  160
cagggccaug aaugagcuga aacuc                                             25


<210>  161
<211>  25
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  25 mer sense strand

<400>  161
agggccauga augagcugca acuca                                             25


<210>  162
<211>  25
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  25 mer sense strand

<400>  162
gggccaugaa ugagcugcaa cucaa                                             25


<210>  163
<211>  25
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  25 mer sense strand

<400>  163
ggccaugaau gagcugcaaa ucaau                                             25


<210>  164
<211>  25
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  25 mer sense strand

<400>  164
gccaugaaug agcugcaaca caaug                                             25


<210>  165
<211>  25
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  25 mer sense strand

<400>  165
ccaugaauga gcugcaacua aauga                                             25


<210>  166
<211>  25
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  25 mer sense strand

<400>  166
cucauugcua ucagcaucua cucug                                             25


<210>  167
<211>  25
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  25 mer sense strand

<400>  167
ucauugcuau cagcaucuua ucugc                                             25


<210>  168
<211>  25
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  25 mer sense strand

<400>  168
cauugcuauc agcaucuuca cugca                                             25


<210>  169
<211>  25
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  25 mer sense strand

<400>  169
auugcuauca gcaucuucua ugcag                                             25


<210>  170
<211>  25
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  25 mer sense strand

<400>  170
uugcuaucag caucuucuca gcaga                                             25


<210>  171
<211>  25
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  25 mer sense strand

<400>  171
ugcuaucagc aucuucucua cagac                                             25


<210>  172
<211>  25
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  25 mer sense strand

<400>  172
gcuaucagca ucuucucuga agacc                                             25


<210>  173
<211>  25
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  25 mer sense strand

<400>  173
cuaucagcau cuucucugca gaccg                                             25


<210>  174
<211>  25
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  25 mer sense strand

<400>  174
uaucagcauc uucucugcaa accgg                                             25


<210>  175
<211>  25
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  25 mer sense strand

<400>  175
aucagcaucu ucucugcaga ccggc                                             25


<210>  176
<211>  25
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  25 mer sense strand

<400>  176
gugcaggacc agcuccagga agaga                                             25


<210>  177
<211>  25
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  25 mer sense strand

<400>  177
gcaggaccag cuccagguaa agagg                                             25


<210>  178
<211>  25
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  25 mer sense strand

<400>  178
gaccagcucc agguagagaa gcugc                                             25


<210>  179
<211>  25
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  25 mer sense strand

<400>  179
accagcucca gguagagaga cugca                                             25


<210>  180
<211>  25
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  25 mer sense strand

<400>  180
ccagcuccag guagagagga ugcag                                             25


<210>  181
<211>  25
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  25 mer sense strand

<400>  181
agcuccaggu agagaggcua cagca                                             25


<210>  182
<211>  25
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  25 mer sense strand

<400>  182
gcuccaggua gagaggcuga agcac                                             25


<210>  183
<211>  25
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  25 mer sense strand

<400>  183
ccagguagag aggcugcaga acaca                                             25


<210>  184
<211>  25
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  25 mer sense strand

<400>  184
agguagagag gcugcagcaa acaua                                             25


<210>  185
<211>  25
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  25 mer sense strand

<400>  185
gguagagagg cugcagcaca cauau                                             25


<210>  186
<211>  25
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  25 mer sense strand

<400>  186
guagagaggc ugcagcacaa auaug                                             25


<210>  187
<211>  25
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  25 mer sense strand

<400>  187
uagagaggcu gcagcacaca uaugu                                             25


<210>  188
<211>  25
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  25 mer sense strand

<400>  188
agagaggcug cagcacacaa augug                                             25


<210>  189
<211>  25
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  25 mer sense strand

<400>  189
gagaggcugc agcacacaua ugugg                                             25


<210>  190
<211>  25
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  25 mer sense strand

<400>  190
agaggcugca gcacacauaa gugga                                             25


<210>  191
<211>  25
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  25 mer sense strand

<400>  191
gaggcugcag cacacauaua uggaa                                             25


<210>  192
<211>  25
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  25 mer sense strand

<400>  192
aggcugcagc acacauauga ggaag                                             25


<210>  193
<211>  25
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  25 mer sense strand

<400>  193
ggcugcagca cacauaugua gaagc                                             25


<210>  194
<211>  25
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  25 mer sense strand

<400>  194
gcugcagcac acauauguga aagcc                                             25


<210>  195
<211>  25
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  25 mer sense strand

<400>  195
cugcagcaca cauaugugga agccc                                             25


<210>  196
<211>  25
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  25 mer sense strand

<400>  196
gcagcacaca uauguggaaa cccug                                             25


<210>  197
<211>  25
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  25 mer sense strand

<400>  197
cagcacacau auguggaaga ccugc                                             25


<210>  198
<211>  25
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  25 mer sense strand

<400>  198
agcacacaua uguggaagca cugca                                             25


<210>  199
<211>  25
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  25 mer sense strand

<400>  199
cacacauaug uggaagccca gcaug                                             25


<210>  200
<211>  25
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  25 mer sense strand

<400>  200
acacauaugu ggaagcccua caugc                                             25


<210>  201
<211>  25
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  25 mer sense strand

<400>  201
cacauaugug gaagcccuga augcc                                             25


<210>  202
<211>  25
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  25 mer sense strand

<400>  202
acauaugugg aagcccugca ugccu                                             25


<210>  203
<211>  25
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  25 mer sense strand

<400>  203
cauaugugga agcccugcaa gccua                                             25


<210>  204
<211>  25
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  25 mer sense strand

<400>  204
auauguggaa gcccugcaua ccuac                                             25


<210>  205
<211>  25
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  25 mer sense strand

<400>  205
uauguggaag cccugcauga cuacg                                             25


<210>  206
<211>  25
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  25 mer sense strand

<400>  206
auguggaagc ccugcaugca uacgu                                             25


<210>  207
<211>  25
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  25 mer sense strand

<400>  207
uguggaagcc cugcaugcca acguc                                             25


<210>  208
<211>  25
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  25 mer sense strand

<400>  208
guggaagccc ugcaugccua cgucu                                             25


<210>  209
<211>  25
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  25 mer sense strand

<400>  209
uggaagcccu gcaugccuaa gucuc                                             25


<210>  210
<211>  25
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  25 mer sense strand

<400>  210
ggaagcccug caugccuaca ucucc                                             25


<210>  211
<211>  25
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  25 mer sense strand

<400>  211
gaagcccugc augccuacga cucca                                             25


<210>  212
<211>  25
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  25 mer sense strand

<400>  212
aagcccugca ugccuacgua uccau                                             25


<210>  213
<211>  25
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  25 mer sense strand

<400>  213
agcccugcau gccuacguca ccauc                                             25


<210>  214
<211>  25
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  25 mer sense strand

<400>  214
gcccugcaug ccuacgucua caucc                                             25


<210>  215
<211>  25
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  25 mer sense strand

<400>  215
cccugcaugc cuacgucuca aucca                                             25


<210>  216
<211>  25
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  25 mer sense strand

<400>  216
ccugcaugcc uacgucucca uccac                                             25


<210>  217
<211>  25
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  25 mer sense strand

<400>  217
cugcaugccu acgucuccaa ccacc                                             25


<210>  218
<211>  25
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  25 mer sense strand

<400>  218
ugcaugccua cgucuccaua cacca                                             25


<210>  219
<211>  25
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  25 mer sense strand

<400>  219
gcaugccuac gucuccauca accau                                             25


<210>  220
<211>  25
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  25 mer sense strand

<400>  220
caugccuacg ucuccaucca ccauc                                             25


<210>  221
<211>  25
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  25 mer sense strand

<400>  221
augccuacgu cuccauccaa caucc                                             25


<210>  222
<211>  25
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  25 mer sense strand

<400>  222
ugccuacguc uccauccaca auccc                                             25


<210>  223
<211>  25
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  25 mer sense strand

<400>  223
gccuacgucu ccauccacca ucccc                                             25


<210>  224
<211>  25
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  25 mer sense strand

<400>  224
ccuacgucuc cauccaccaa cccca                                             25


<210>  225
<211>  25
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  25 mer sense strand

<400>  225
cuacgucucc auccaccaua cccau                                             25


<210>  226
<211>  25
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  25 mer sense strand

<400>  226
uacgucucca uccaccauca ccaug                                             25


<210>  227
<211>  25
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  25 mer sense strand

<400>  227
acgucuccau ccaccaucca cauga                                             25


<210>  228
<211>  25
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  25 mer sense strand

<400>  228
cgucuccauc caccauccca augac                                             25


<210>  229
<211>  25
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  25 mer sense strand

<400>  229
gucuccaucc accaucccca ugacc                                             25


<210>  230
<211>  25
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  25 mer sense strand

<400>  230
cuccauccac cauccccaua accga                                             25


<210>  231
<211>  25
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  25 mer sense strand

<400>  231
uccauccacc auccccauga ccgac                                             25


<210>  232
<211>  25
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  25 mer sense strand

<400>  232
ccauccacca uccccaugaa cgacu                                             25


<210>  233
<211>  25
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  25 mer sense strand

<400>  233
cauccaccau ccccaugaca gacug                                             25


<210>  234
<211>  25
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  25 mer sense strand

<400>  234
auccaccauc cccaugacca acuga                                             25


<210>  235
<211>  25
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  25 mer sense strand

<400>  235
uccaccaucc ccaugaccga cugau                                             25


<210>  236
<211>  25
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  25 mer sense strand

<400>  236
ccaccauccc caugaccgaa ugaug                                             25


<210>  237
<211>  25
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  25 mer sense strand

<400>  237
caccaucccc augaccgaca gaugu                                             25


<210>  238
<211>  25
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  25 mer sense strand

<400>  238
accaucccca ugaccgacua auguu                                             25


<210>  239
<211>  25
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  25 mer sense strand

<400>  239
ccauccccau gaccgacuga uguuc                                             25


<210>  240
<211>  25
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  25 mer sense strand

<400>  240
cauccccaug accgacugaa guucc                                             25


<210>  241
<211>  25
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  25 mer sense strand

<400>  241
auccccauga ccgacugaua uuccc                                             25


<210>  242
<211>  25
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  25 mer sense strand

<400>  242
uccccaugac cgacugauga uccca                                             25


<210>  243
<211>  25
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  25 mer sense strand

<400>  243
ccccaugacc gacugaugua cccac                                             25


<210>  244
<211>  25
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  25 mer sense strand

<400>  244
cccaugaccg acugauguua ccacg                                             25


<210>  245
<211>  25
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  25 mer sense strand

<400>  245
ccaugaccga cugauguuca cacgg                                             25


<210>  246
<211>  25
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  25 mer sense strand

<400>  246
augaccgacu gauguuccca cggau                                             25


<210>  247
<211>  25
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  25 mer sense strand

<400>  247
ugaccgacug auguucccaa ggaug                                             25


<210>  248
<211>  25
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  25 mer sense strand

<400>  248
gaccgacuga uguucccaca gaugc                                             25


<210>  249
<211>  25
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  25 mer sense strand

<400>  249
accgacugau guucccacga augcu                                             25


<210>  250
<211>  25
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  25 mer sense strand

<400>  250
ccgacugaug uucccacgga ugcua                                             25


<210>  251
<211>  25
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  25 mer sense strand

<400>  251
gacugauguu cccacggaua cuaau                                             25


<210>  252
<211>  25
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  25 mer sense strand

<400>  252
acugauguuc ccacggauga uaaug                                             25


<210>  253
<211>  25
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  25 mer sense strand

<400>  253
ugauguuccc acggaugcua augaa                                             25


<210>  254
<211>  25
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  25 mer sense strand

<400>  254
gauguuccca cggaugcuaa ugaaa                                             25


<210>  255
<211>  25
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  25 mer sense strand

<400>  255
uguucccacg gaugcuaaua aaacu                                             25


<210>  256
<211>  25
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  25 mer sense strand

<400>  256
guucccacgg augcuaauga aacug                                             25


<210>  257
<211>  25
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  25 mer sense strand

<400>  257
uucccacgga ugcuaaugaa acugg                                             25


<210>  258
<211>  25
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  25 mer sense strand

<400>  258
ucccacggau gcuaaugaaa cuggu                                             25


<210>  259
<211>  25
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  25 mer sense strand

<400>  259
cccacggaug cuaaugaaaa uggug                                             25


<210>  260
<211>  25
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  25 mer sense strand

<400>  260
ccacggaugc uaaugaaaca gguga                                             25


<210>  261
<211>  25
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  25 mer sense strand

<400>  261
cacggaugcu aaugaaacua gugag                                             25


<210>  262
<211>  25
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  25 mer sense strand

<400>  262
acggaugcua augaaacuga ugagc                                             25


<210>  263
<211>  25
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  25 mer sense strand

<400>  263
cggaugcuaa ugaaacugga gagcc                                             25


<210>  264
<211>  25
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  25 mer sense strand

<400>  264
ggaugcuaau gaaacuggua agccu                                             25


<210>  265
<211>  25
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  25 mer sense strand

<400>  265
gaugcuaaug aaacugguga gccuc                                             25


<210>  266
<211>  25
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  25 mer sense strand

<400>  266
ugcuaaugaa acuggugaga cuccg                                             25


<210>  267
<211>  25
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  25 mer sense strand

<400>  267
gcuaaugaaa cuggugagca uccgg                                             25


<210>  268
<211>  25
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  25 mer sense strand

<400>  268
cuaaugaaac uggugagcca ccgga                                             25


<210>  269
<211>  25
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  25 mer sense strand

<400>  269
uaaugaaacu ggugagccua cggac                                             25


<210>  270
<211>  25
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  25 mer sense strand

<400>  270
aaugaaacug gugagccuca ggacc                                             25


<210>  271
<211>  25
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  25 mer sense strand

<400>  271
augaaacugg ugagccucca gaccc                                             25


<210>  272
<211>  25
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  25 mer sense strand

<400>  272
ugaaacuggu gagccuccga acccu                                             25


<210>  273
<211>  25
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  25 mer sense strand

<400>  273
aaacugguga gccuccggaa ccuga                                             25


<210>  274
<211>  25
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  25 mer sense strand

<400>  274
aacuggugag ccuccggaca cugag                                             25


<210>  275
<211>  25
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  25 mer sense strand

<400>  275
cuggugagcc uccggaccca gagca                                             25


<210>  276
<211>  25
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  25 mer sense strand

<400>  276
ccggacccug agcagcguca acuca                                             25


<210>  277
<211>  25
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  25 mer sense strand

<400>  277
ggacccugag cagcguccaa ucaga                                             25


<210>  278
<211>  25
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  25 mer sense strand

<400>  278
gacccugagc agcguccaca cagag                                             25


<210>  279
<211>  25
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  25 mer sense strand

<400>  279
acccugagca gcguccacua agagc                                             25


<210>  280
<211>  25
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  25 mer sense strand

<400>  280
cccugagcag cguccacuca gagca                                             25


<210>  281
<211>  25
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  25 mer sense strand

<400>  281
ccugagcagc guccacucaa agcaa                                             25


<210>  282
<211>  25
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  25 mer sense strand

<400>  282
cugagcagcg uccacucaga gcaag                                             25


<210>  283
<211>  25
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  25 mer sense strand

<400>  283
ugagcagcgu ccacucagaa caagu                                             25


<210>  284
<211>  25
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  25 mer sense strand

<400>  284
gagcagcguc cacucagaga aagug                                             25


<210>  285
<211>  25
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  25 mer sense strand

<400>  285
agcagcgucc acucagagca agugu                                             25


<210>  286
<211>  25
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  25 mer sense strand

<400>  286
gcagcgucca cucagagcaa guguu                                             25


<210>  287
<211>  25
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  25 mer sense strand

<400>  287
cagcguccac ucagagcaaa uguuu                                             25


<210>  288
<211>  25
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  25 mer sense strand

<400>  288
agcguccacu cagagcaaga guuug                                             25


<210>  289
<211>  25
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  25 mer sense strand

<400>  289
gcguccacuc agagcaagua uuugc                                             25


<210>  290
<211>  25
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  25 mer sense strand

<400>  290
cguccacuca gagcaaguga uugca                                             25


<210>  291
<211>  25
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  25 mer sense strand

<400>  291
guccacucag agcaagugua ugcac                                             25


<210>  292
<211>  25
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  25 mer sense strand

<400>  292
uccacucaga gcaaguguua gcacu                                             25


<210>  293
<211>  25
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  25 mer sense strand

<400>  293
ccacucagag caaguguuua cacug                                             25


<210>  294
<211>  25
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  25 mer sense strand

<400>  294
acucagagca aguguuugca cugcg                                             25


<210>  295
<211>  25
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  25 mer sense strand

<400>  295
cucagagcaa guguuugcaa ugcgu                                             25


<210>  296
<211>  25
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  25 mer sense strand

<400>  296
ucagagcaag uguuugcaca gcguc                                             25


<210>  297
<211>  25
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  25 mer sense strand

<400>  297
cagagcaagu guuugcacua cgucu                                             25


<210>  298
<211>  25
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  25 mer sense strand

<400>  298
agagcaagug uuugcacuga gucug                                             25


<210>  299
<211>  25
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  25 mer sense strand

<400>  299
gagcaagugu uugcacugca ucugc                                             25


<210>  300
<211>  25
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  25 mer sense strand

<400>  300
agcaaguguu ugcacugcga cugca                                             25


<210>  301
<211>  25
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  25 mer sense strand

<400>  301
gcaaguguuu gcacugcgua ugcag                                             25


<210>  302
<211>  25
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  25 mer sense strand

<400>  302
caaguguuug cacugcguca gcagg                                             25


<210>  303
<211>  25
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  25 mer sense strand

<400>  303
aaguguuugc acugcgucua cagga                                             25


<210>  304
<211>  25
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  25 mer sense strand

<400>  304
aguguuugca cugcgucuga aggac                                             25


<210>  305
<211>  25
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  25 mer sense strand

<400>  305
guguuugcac ugcgucugca ggaca                                             25


<210>  306
<211>  25
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  25 mer sense strand

<400>  306
uguuugcacu gcgucugcaa gacaa                                             25


<210>  307
<211>  25
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  25 mer sense strand

<400>  307
guuugcacug cgucugcaga acaaa                                             25


<210>  308
<211>  25
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  25 mer sense strand

<400>  308
uuugcacugc gucugcagga caaaa                                             25


<210>  309
<211>  25
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  25 mer sense strand

<400>  309
uugcacugcg ucugcaggaa aaaaa                                             25


<210>  310
<211>  25
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  25 mer sense strand

<400>  310
ugcacugcgu cugcaggaca aaaag                                             25


<210>  311
<211>  25
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  25 mer sense strand

<400>  311
gcacugcguc ugcaggacaa aaagc                                             25


<210>  312
<211>  25
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  25 mer sense strand

<400>  312
cacugcgucu gcaggacaaa aagcu                                             25


<210>  313
<211>  25
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  25 mer sense strand

<400>  313
acugcgucug caggacaaaa agcuc                                             25


<210>  314
<211>  25
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  25 mer sense strand

<400>  314
cugcgucugc aggacaaaaa gcucc                                             25


<210>  315
<211>  25
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  25 mer sense strand

<400>  315
ugcgucugca ggacaaaaaa cuccc                                             25


<210>  316
<211>  25
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  25 mer sense strand

<400>  316
gcgucugcag gacaaaaaga uccca                                             25


<210>  317
<211>  25
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  25 mer sense strand

<400>  317
cgucugcagg acaaaaagca cccac                                             25


<210>  318
<211>  25
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  25 mer sense strand

<400>  318
gucugcagga caaaaagcua ccacc                                             25


<210>  319
<211>  25
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  25 mer sense strand

<400>  319
ucugcaggac aaaaagcuca caccg                                             25


<210>  320
<211>  25
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  25 mer sense strand

<400>  320
cugcaggaca aaaagcucca accgc                                             25


<210>  321
<211>  25
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  25 mer sense strand

<400>  321
gcaggacaaa aagcucccaa cgcug                                             25


<210>  322
<211>  25
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  25 mer sense strand

<400>  322
caggacaaaa agcucccaca gcugc                                             25


<210>  323
<211>  25
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  25 mer sense strand

<400>  323
aggacaaaaa gcucccacca cugcu                                             25


<210>  324
<211>  25
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  25 mer sense strand

<400>  324
ggacaaaaag cucccaccga ugcuc                                             25


<210>  325
<211>  25
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  25 mer sense strand

<400>  325
acaaaaagcu cccaccgcua cucuc                                             25


<210>  326
<211>  25
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  25 mer sense strand

<400>  326
caaaaagcuc ccaccgcuga ucucu                                             25


<210>  327
<211>  25
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  25 mer sense strand

<400>  327
aaaaagcucc caccgcugca cucug                                             25


<210>  328
<211>  25
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  25 mer sense strand

<400>  328
aaaagcuccc accgcugcua ucuga                                             25


<210>  329
<211>  25
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  25 mer sense strand

<400>  329
aaagcuccca ccgcugcuca cugag                                             25


<210>  330
<211>  25
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  25 mer sense strand

<400>  330
aagcucccac cgcugcucua ugaga                                             25


<210>  331
<211>  25
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  25 mer sense strand

<400>  331
agcucccacc gcugcucuca gagau                                             25


<210>  332
<211>  25
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  25 mer sense strand

<400>  332
gcucccaccg cugcucucua agauc                                             25


<210>  333
<211>  25
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  25 mer sense strand

<400>  333
ucccaccgcu gcucucugaa aucug                                             25


<210>  334
<211>  25
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  25 mer sense strand

<400>  334
ccaccgcugc ucucugagaa cuggg                                             25


<210>  335
<211>  25
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  25 mer sense strand

<400>  335
caccgcugcu cucugagaua uggga                                             25


<210>  336
<211>  25
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  25 mer sense strand

<400>  336
ccgcugcucu cugagaucua ggaug                                             25


<210>  337
<211>  25
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  25 mer sense strand

<400>  337
cgcugcucuc ugagaucuga gaugu                                             25


<210>  338
<211>  25
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  25 mer sense strand

<400>  338
gcugcucucu gagaucugga augug                                             25


<210>  339
<211>  25
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  25 mer sense strand

<400>  339
gcucucugag aucugggaua ugcac                                             25


<210>  340
<211>  25
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  25 mer sense strand

<400>  340
ucucugagau cugggaugua cacga                                             25


<210>  341
<211>  25
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  25 mer sense strand

<400>  341
cucugagauc ugggauguga acgaa                                             25


<210>  342
<211>  25
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  25 mer sense strand

<400>  342
ucugagaucu gggaugugca cgaau                                             25


<210>  343
<211>  25
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  25 mer sense strand

<400>  343
cugagaucug ggaugugcaa gaaug                                             25


<210>  344
<211>  25
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  25 mer sense strand

<400>  344
ugagaucugg gaugugcaca aauga                                             25


<210>  345
<211>  25
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  25 mer sense strand

<400>  345
gagaucuggg augugcacga augac                                             25


<210>  346
<211>  25
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  25 mer sense strand

<400>  346
agaucuggga ugugcacgaa ugacu                                             25


<210>  347
<211>  25
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  25 mer sense strand

<400>  347
gaucugggau gugcacgaaa gacug                                             25


<210>  348
<211>  25
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  25 mer sense strand

<400>  348
aucugggaug ugcacgaaua acugu                                             25


<210>  349
<211>  25
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  25 mer sense strand

<400>  349
ucugggaugu gcacgaauga cuguu                                             25


<210>  350
<211>  25
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  25 mer sense strand

<400>  350
cugggaugug cacgaaugaa uguuc                                             25


<210>  351
<211>  25
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  25 mer sense strand

<400>  351
ugggaugugc acgaaugaca guucu                                             25


<210>  352
<211>  25
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  25 mer sense strand

<400>  352
gggaugugca cgaaugacua uucug                                             25


<210>  353
<211>  25
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  25 mer sense strand

<400>  353
ggaugugcac gaaugacuga ucugu                                             25


<210>  354
<211>  25
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  25 mer sense strand

<400>  354
gaugugcacg aaugacugua cuguc                                             25


<210>  355
<211>  25
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  25 mer sense strand

<400>  355
ugguggcugc cuccuagaaa uggaa                                             25


<210>  356
<211>  25
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  25 mer sense strand

<400>  356
gguggcugcc uccuagaaga ggaac                                             25


<210>  357
<211>  25
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  25 mer sense strand

<400>  357
guggcugccu ccuagaagua gaaca                                             25


<210>  358
<211>  25
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  25 mer sense strand

<400>  358
uggcugccuc cuagaaguga aacag                                             25


<210>  359
<211>  25
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  25 mer sense strand

<400>  359
ggcugccucc uagaagugga acaga                                             25


<210>  360
<211>  25
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  25 mer sense strand

<400>  360
gcugccuccu agaaguggaa cagac                                             25


<210>  361
<211>  25
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  25 mer sense strand

<400>  361
cugccuccua gaaguggaaa agacu                                             25


<210>  362
<211>  25
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  25 mer sense strand

<400>  362
ugccuccuag aaguggaaca gacug                                             25


<210>  363
<211>  25
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  25 mer sense strand

<400>  363
gccuccuaga aguggaacaa acuga                                             25


<210>  364
<211>  25
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  25 mer sense strand

<400>  364
ccuccuagaa guggaacaga cugag                                             25


<210>  365
<211>  25
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  25 mer sense strand

<400>  365
cuccuagaag uggaacagaa ugaga                                             25


<210>  366
<211>  25
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  25 mer sense strand

<400>  366
uccuagaagu ggaacagaca gagaa                                             25


<210>  367
<211>  25
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  25 mer sense strand

<400>  367
ccuagaagug gaacagacua agaag                                             25


<210>  368
<211>  25
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  25 mer sense strand

<400>  368
cuagaagugg aacagacuga gaagg                                             25


<210>  369
<211>  25
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  25 mer sense strand

<400>  369
agaaguggaa cagacugaga agggc                                             25


<210>  370
<211>  25
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  25 mer sense strand

<400>  370
ggaacagacu gagaagggca aacau                                             25


<210>  371
<211>  25
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  25 mer sense strand

<400>  371
aacagacuga gaagggcaaa cauuc                                             25


<210>  372
<211>  25
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  25 mer sense strand

<400>  372
acagacugag aagggcaaaa auucc                                             25


<210>  373
<211>  25
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  25 mer sense strand

<400>  373
cagacugaga agggcaaaca uuccu                                             25


<210>  374
<211>  25
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  25 mer sense strand

<400>  374
agacugagaa gggcaaacaa uccug                                             25


<210>  375
<211>  25
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  25 mer sense strand

<400>  375
gacugagaag ggcaaacaua ccugg                                             25


<210>  376
<211>  25
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  25 mer sense strand

<400>  376
acugagaagg gcaaacauua cuggg                                             25


<210>  377
<211>  25
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  25 mer sense strand

<400>  377
cugagaaggg caaacauuca uggga                                             25


<210>  378
<211>  25
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  25 mer sense strand

<400>  378
ugagaagggc aaacauucca gggag                                             25


<210>  379
<211>  25
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  25 mer sense strand

<400>  379
gagaagggca aacauuccua ggagc                                             25


<210>  380
<211>  25
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  25 mer sense strand

<400>  380
cccguggcau uaaaagagaa ucaaa                                             25


<210>  381
<211>  25
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  25 mer sense strand

<400>  381
ccguggcauu aaaagagaga caaag                                             25


<210>  382
<211>  25
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  25 mer sense strand

<400>  382
cguggcauua aaagagagua aaagg                                             25


<210>  383
<211>  25
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  25 mer sense strand

<400>  383
guggcauuaa aagagaguca aaggg                                             25


<210>  384
<211>  25
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  25 mer sense strand

<400>  384
uggcauuaaa agagagucaa agggu                                             25


<210>  385
<211>  27
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  27 mer antisense strand

<400>  385
gcggaucugu ucuucugaca ggacaca                                           27


<210>  386
<211>  27
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  27 mer antisense strand

<400>  386
aggcguaucu guucuucuga caggaca                                           27


<210>  387
<211>  27
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  27 mer antisense strand

<400>  387
ccucuugccg cuucaguuuc uucaggc                                           27


<210>  388
<211>  27
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  27 mer antisense strand

<400>  388
uccucuugcc gcuucaguuu cuucagg                                           27


<210>  389
<211>  27
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  27 mer antisense strand

<400>  389
cuccuuuugc cgcuucaguu ucuucag                                           27


<210>  390
<211>  27
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  27 mer antisense strand

<400>  390
ccuccucuug ccgcuucagu uucuuca                                           27


<210>  391
<211>  27
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  27 mer antisense strand

<400>  391
uccucuucuu gccgcuucag uuucuuc                                           27


<210>  392
<211>  27
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  27 mer antisense strand

<400>  392
guuccuccuc uugccgcuuc aguuucu                                           27


<210>  393
<211>  27
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  27 mer antisense strand

<400>  393
uguucuuccu cuugccgcuu caguuuc                                           27


<210>  394
<211>  27
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  27 mer antisense strand

<400>  394
cuguuucucc ucuugccgcu ucaguuu                                           27


<210>  395
<211>  27
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  27 mer antisense strand

<400>  395
ccuguuccuc cucuugccgc uucaguu                                           27


<210>  396
<211>  27
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  27 mer antisense strand

<400>  396
gccuguuccu ccucuugccg cuucagu                                           27


<210>  397
<211>  27
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  27 mer antisense strand

<400>  397
ugagcuuguu ccuccucuug ccgcuuc                                           27


<210>  398
<211>  27
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  27 mer antisense strand

<400>  398
augagucugu uccuccucuu gccgcuu                                           27


<210>  399
<211>  27
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  27 mer antisense strand

<400>  399
caugauccug uuccuccucu ugccgcu                                           27


<210>  400
<211>  27
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  27 mer antisense strand

<400>  400
ggcauuagcc uguuccuccu cuugccg                                           27


<210>  401
<211>  27
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  27 mer antisense strand

<400>  401
guggcuugag ccuguuccuc cucuugc                                           27


<210>  402
<211>  27
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  27 mer antisense strand

<400>  402
ugugguauga gccuguuccu ccucuug                                           27


<210>  403
<211>  27
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  27 mer antisense strand

<400>  403
augugucaug agccuguucc uccucuu                                           27


<210>  404
<211>  27
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  27 mer antisense strand

<400>  404
gauguugcau gagccuguuc cuccucu                                           27


<210>  405
<211>  27
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  27 mer antisense strand

<400>  405
aggauuuggc augagccugu uccuccu                                           27


<210>  406
<211>  27
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  27 mer antisense strand

<400>  406
auuugugggg gugaggaagc ccugggg                                           27


<210>  407
<211>  27
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  27 mer antisense strand

<400>  407
gcgacuagcu ucucgaucau gcccagu                                           27


<210>  408
<211>  27
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  27 mer antisense strand

<400>  408
gcagcuacga gcuucucgau caugccc                                           27


<210>  409
<211>  27
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  27 mer antisense strand

<400>  409
gguuauacug uugcugggca gcgacga                                           27


<210>  410
<211>  27
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  27 mer antisense strand

<400>  410
ccgguuacac uguugcuggg cagcgac                                           27


<210>  411
<211>  27
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  27 mer antisense strand

<400>  411
gagcgucggu uacacuguug cugggca                                           27


<210>  412
<211>  27
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  27 mer antisense strand

<400>  412
aggagugccg guuacacugu ugcuggg                                           27


<210>  413
<211>  27
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  27 mer antisense strand

<400>  413
aaggaucgcc gguuacacug uugcugg                                           27


<210>  414
<211>  27
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  27 mer antisense strand

<400>  414
aaaaguagcg ccgguuacac uguugcu                                           27


<210>  415
<211>  27
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  27 mer antisense strand

<400>  415
gaaaaugagc gccgguuaca cuguugc                                           27


<210>  416
<211>  27
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  27 mer antisense strand

<400>  416
agaaauggag cgccgguuac acuguug                                           27


<210>  417
<211>  27
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  27 mer antisense strand

<400>  417
cagaauagga gcgccgguua cacuguu                                           27


<210>  418
<211>  27
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  27 mer antisense strand

<400>  418
ucagauaagg agcgccgguu acacugu                                           27


<210>  419
<211>  27
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  27 mer antisense strand

<400>  419
gucaguaaag gagcgccggu uacacug                                           27


<210>  420
<211>  27
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  27 mer antisense strand

<400>  420
ggucauaaaa ggagcgccgg uuacacu                                           27


<210>  421
<211>  27
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  27 mer antisense strand

<400>  421
ucgaauccgg ucagaaaagg agcgccg                                           27


<210>  422
<211>  27
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  27 mer antisense strand

<400>  422
gacucuaagc cggucagaaa aggagcg                                           27


<210>  423
<211>  27
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  27 mer antisense strand

<400>  423
ugacuugaag ccggucagaa aaggagc                                           27


<210>  424
<211>  27
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  27 mer antisense strand

<400>  424
gugacucgaa gccggucaga aaaggag                                           27


<210>  425
<211>  27
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  27 mer antisense strand

<400>  425
cgugauucga agccggucag aaaagga                                           27


<210>  426
<211>  27
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  27 mer antisense strand

<400>  426
ggcguuacuc gaagccgguc agaaaag                                           27


<210>  427
<211>  27
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  27 mer antisense strand

<400>  427
aaggcuugac ucgaagccgg ucagaaa                                           27


<210>  428
<211>  27
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  27 mer antisense strand

<400>  428
caagguguga cucgaagccg gucagaa                                           27


<210>  429
<211>  27
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  27 mer antisense strand

<400>  429
ccaagucgug acucgaagcc ggucaga                                           27


<210>  430
<211>  27
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  27 mer antisense strand

<400>  430
ccgaguuguc uccagaagca ucaccug                                           27


<210>  431
<211>  27
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  27 mer antisense strand

<400>  431
cuccgugaug ucuccagaag caucacc                                           27


<210>  432
<211>  27
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  27 mer antisense strand

<400>  432
ccuccuagau gucuccagaa gcaucac                                           27


<210>  433
<211>  27
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  27 mer antisense strand

<400>  433
accucugaga ugucuccaga agcauca                                           27


<210>  434
<211>  27
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  27 mer antisense strand

<400>  434
uaccuucgag augucuccag aagcauc                                           27


<210>  435
<211>  27
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  27 mer antisense strand

<400>  435
guaccuccga gaugucucca gaagcau                                           27


<210>  436
<211>  27
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  27 mer antisense strand

<400>  436
uguacuuccg agaugucucc agaagca                                           27


<210>  437
<211>  27
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  27 mer antisense strand

<400>  437
uuguaucucc gagaugucuc cagaagc                                           27


<210>  438
<211>  27
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  27 mer antisense strand

<400>  438
guuguuccuc cgagaugucu ccagaag                                           27


<210>  439
<211>  27
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  27 mer antisense strand

<400>  439
gguuguaccu ccgagauguc uccagaa                                           27


<210>  440
<211>  27
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  27 mer antisense strand

<400>  440
ggguuuuacc uccgagaugu cuccaga                                           27


<210>  441
<211>  27
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  27 mer antisense strand

<400>  441
aggguuguac cuccgagaug ucuccag                                           27


<210>  442
<211>  27
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  27 mer antisense strand

<400>  442
caggguugua ccuccgagau gucucca                                           27


<210>  443
<211>  27
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  27 mer antisense strand

<400>  443
ccagguuugu accuccgaga ugucucc                                           27


<210>  444
<211>  27
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  27 mer antisense strand

<400>  444
cccaguguug uaccuccgag augucuc                                           27


<210>  445
<211>  27
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  27 mer antisense strand

<400>  445
ucccaugguu guaccuccga gaugucu                                           27


<210>  446
<211>  27
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  27 mer antisense strand

<400>  446
acuccuaggg uuguaccucc gagaugu                                           27


<210>  447
<211>  27
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  27 mer antisense strand

<400>  447
cacucucagg guuguaccuc cgagaug                                           27


<210>  448
<211>  27
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  27 mer antisense strand

<400>  448
ucacuuccag gguuguaccu ccgagau                                           27


<210>  449
<211>  27
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  27 mer antisense strand

<400>  449
ucucauuccc aggguuguac cuccgag                                           27


<210>  450
<211>  27
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  27 mer antisense strand

<400>  450
acucuuacuc ccaggguugu accuccg                                           27


<210>  451
<211>  27
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  27 mer antisense strand

<400>  451
uacucucacu cccaggguug uaccucc                                           27


<210>  452
<211>  27
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  27 mer antisense strand

<400>  452
auacuuucac ucccaggguu guaccuc                                           27


<210>  453
<211>  27
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  27 mer antisense strand

<400>  453
gauacucuca cucccagggu uguaccu                                           27


<210>  454
<211>  27
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  27 mer antisense strand

<400>  454
ugauauucuc acucccaggg uuguacc                                           27


<210>  455
<211>  27
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  27 mer antisense strand

<400>  455
gugauucucu cacucccagg guuguac                                           27


<210>  456
<211>  27
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  27 mer antisense strand

<400>  456
ggugauacuc ucacucccag gguugua                                           27


<210>  457
<211>  27
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  27 mer antisense strand

<400>  457
agguguuacu cucacuccca ggguugu                                           27


<210>  458
<211>  27
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  27 mer antisense strand

<400>  458
aagguuauac ucucacuccc aggguug                                           27


<210>  459
<211>  27
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  27 mer antisense strand

<400>  459
gaaggugaua cucucacucc caggguu                                           27


<210>  460
<211>  27
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  27 mer antisense strand

<400>  460
ggaaguugau acucucacuc ccagggu                                           27


<210>  461
<211>  27
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  27 mer antisense strand

<400>  461
aggaauguga uacucucacu cccaggg                                           27


<210>  462
<211>  27
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  27 mer antisense strand

<400>  462
gaggauggug auacucucac ucccagg                                           27


<210>  463
<211>  27
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  27 mer antisense strand

<400>  463
ugagguaggu gauacucuca cucccag                                           27


<210>  464
<211>  27
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  27 mer antisense strand

<400>  464
cuugaugaag gugauacucu cacuccc                                           27


<210>  465
<211>  27
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  27 mer antisense strand

<400>  465
ccuuguggaa ggugauacuc ucacucc                                           27


<210>  466
<211>  27
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  27 mer antisense strand

<400>  466
uccuuuagga aggugauacu cucacuc                                           27


<210>  467
<211>  27
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  27 mer antisense strand

<400>  467
auccuugagg aaggugauac ucucacu                                           27


<210>  468
<211>  27
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  27 mer antisense strand

<400>  468
aauccuugag gaaggugaua cucucac                                           27


<210>  469
<211>  27
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  27 mer antisense strand

<400>  469
gaaauucuug aggaagguga uacucuc                                           27


<210>  470
<211>  27
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  27 mer antisense strand

<400>  470
ugaaauccuu gaggaaggug auacucu                                           27


<210>  471
<211>  27
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  27 mer antisense strand

<400>  471
cugaauuccu ugaggaaggu gauacuc                                           27


<210>  472
<211>  27
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  27 mer antisense strand

<400>  472
acugauaucc uugaggaagg ugauacu                                           27


<210>  473
<211>  27
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  27 mer antisense strand

<400>  473
aacuguaauc cuugaggaag gugauac                                           27


<210>  474
<211>  27
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  27 mer antisense strand

<400>  474
uauaauugaa auccuugagg aagguga                                           27


<210>  475
<211>  27
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  27 mer antisense strand

<400>  475
uuauaucuga aauccuugag gaaggug                                           27


<210>  476
<211>  27
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  27 mer antisense strand

<400>  476
cgguuuuaac ugaaauccuu gaggaag                                           27


<210>  477
<211>  27
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  27 mer antisense strand

<400>  477
uucccuguua uaacugaaau ccuugag                                           27


<210>  478
<211>  27
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  27 mer antisense strand

<400>  478
cuuccugguu auaacugaaa uccuuga                                           27


<210>  479
<211>  27
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  27 mer antisense strand

<400>  479
ucuucucggu uauaacugaa auccuug                                           27


<210>  480
<211>  27
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  27 mer antisense strand

<400>  480
gucuuuccgg uuauaacuga aauccuu                                           27


<210>  481
<211>  27
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  27 mer antisense strand

<400>  481
agucuucccg guuauaacug aaauccu                                           27


<210>  482
<211>  27
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  27 mer antisense strand

<400>  482
aagucuuccc gguuauaacu gaaaucc                                           27


<210>  483
<211>  27
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  27 mer antisense strand

<400>  483
aaaguuuucc cgguuauaac ugaaauc                                           27


<210>  484
<211>  27
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  27 mer antisense strand

<400>  484
caaagucuuc ccgguuauaa cugaaau                                           27


<210>  485
<211>  27
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  27 mer antisense strand

<400>  485
gcaaauucuu cccgguuaua acugaaa                                           27


<210>  486
<211>  27
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  27 mer antisense strand

<400>  486
ggcaaugucu ucccgguuau aacugaa                                           27


<210>  487
<211>  27
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  27 mer antisense strand

<400>  487
uuggcuaagu cuucccgguu auaacug                                           27


<210>  488
<211>  27
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  27 mer antisense strand

<400>  488
uuugguaaag ucuucccggu uauaacu                                           27


<210>  489
<211>  27
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  27 mer antisense strand

<400>  489
cuuugucaaa gucuucccgg uuauaac                                           27


<210>  490
<211>  27
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  27 mer antisense strand

<400>  490
gcuuuugcaa agucuucccg guuauaa                                           27


<210>  491
<211>  27
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  27 mer antisense strand

<400>  491
ugcuuuggca aagucuuccc gguuaua                                           27


<210>  492
<211>  27
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  27 mer antisense strand

<400>  492
cugcuuuggc aaagucuucc cgguuau                                           27


<210>  493
<211>  27
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  27 mer antisense strand

<400>  493
ccugcuuugg caaagucuuc ccgguua                                           27


<210>  494
<211>  27
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  27 mer antisense strand

<400>  494
cccuguuuug gcaaagucuu cccgguu                                           27


<210>  495
<211>  27
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  27 mer antisense strand

<400>  495
cagccuugcu uuggcaaagu cuucccg                                           27


<210>  496
<211>  27
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  27 mer antisense strand

<400>  496
gcagcucugc uuuggcaaag ucuuccc                                           27


<210>  497
<211>  27
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  27 mer antisense strand

<400>  497
ugcaguccug cuuuggcaaa gucuucc                                           27


<210>  498
<211>  27
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  27 mer antisense strand

<400>  498
uugcaucccu gcuuuggcaa agucuuc                                           27


<210>  499
<211>  27
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  27 mer antisense strand

<400>  499
cuugcugccc ugcuuuggca aagucuu                                           27


<210>  500
<211>  27
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  27 mer antisense strand

<400>  500
acuuguagcc cugcuuuggc aaagucu                                           27


<210>  501
<211>  27
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  27 mer antisense strand

<400>  501
cacuuucagc ccugcuuugg caaaguc                                           27


<210>  502
<211>  27
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  27 mer antisense strand

<400>  502
uuccauuugc agcccugcuu uggcaaa                                           27


<210>  503
<211>  27
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  27 mer antisense strand

<400>  503
auuccucuug cagcccugcu uuggcaa                                           27


<210>  504
<211>  27
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  27 mer antisense strand

<400>  504
aauucuacuu gcagcccugc uuuggca                                           27


<210>  505
<211>  27
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  27 mer antisense strand

<400>  505
gaauuucacu ugcagcccug cuuuggc                                           27


<210>  506
<211>  27
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  27 mer antisense strand

<400>  506
ugaauuccac uugcagcccu gcuuugg                                           27


<210>  507
<211>  27
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  27 mer antisense strand

<400>  507
augaauucca cuugcagccc ugcuuug                                           27


<210>  508
<211>  27
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  27 mer antisense strand

<400>  508
gaugauuucc acuugcagcc cugcuuu                                           27


<210>  509
<211>  27
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  27 mer antisense strand

<400>  509
ugauguauuc cacuugcagc ccugcuu                                           27


<210>  510
<211>  27
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  27 mer antisense strand

<400>  510
guugaugaau uccacuugca gcccugc                                           27


<210>  511
<211>  27
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  27 mer antisense strand

<400>  511
gguuguugaa uuccacuugc agcccug                                           27


<210>  512
<211>  27
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  27 mer antisense strand

<400>  512
ggguuuauga auuccacuug cagcccu                                           27


<210>  513
<211>  27
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  27 mer antisense strand

<400>  513
gggguugaug aauuccacuu gcagccc                                           27


<210>  514
<211>  27
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  27 mer antisense strand

<400>  514
gaugguguug augaauucca cuugcag                                           27


<210>  515
<211>  27
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  27 mer antisense strand

<400>  515
aagauugggu ugaugaauuc cacuugc                                           27


<210>  516
<211>  27
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  27 mer antisense strand

<400>  516
gaagaugggg uugaugaauu ccacuug                                           27


<210>  517
<211>  27
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  27 mer antisense strand

<400>  517
ucgaauaugg gguugaugaa uuccacu                                           27


<210>  518
<211>  27
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  27 mer antisense strand

<400>  518
cucgaugaug ggguugauga auuccac                                           27


<210>  519
<211>  27
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  27 mer antisense strand

<400>  519
gaacuugaag augggguuga ugaauuc                                           27


<210>  520
<211>  27
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  27 mer antisense strand

<400>  520
agaacucgaa gaugggguug augaauu                                           27


<210>  521
<211>  27
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  27 mer antisense strand

<400>  521
gagaauucga agaugggguu gaugaau                                           27


<210>  522
<211>  27
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  27 mer antisense strand

<400>  522
ggagaucucg aagauggggu ugaugaa                                           27


<210>  523
<211>  27
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  27 mer antisense strand

<400>  523
uggaguacuc gaagaugggg uugauga                                           27


<210>  524
<211>  27
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  27 mer antisense strand

<400>  524
cuggauaacu cgaagauggg guugaug                                           27


<210>  525
<211>  27
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  27 mer antisense strand

<400>  525
ccuggugaac ucgaagaugg gguugau                                           27


<210>  526
<211>  27
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  27 mer antisense strand

<400>  526
cccuguagaa cucgaagaug ggguuga                                           27


<210>  527
<211>  27
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  27 mer antisense strand

<400>  527
gcccuugaga acucgaagau gggguug                                           27


<210>  528
<211>  27
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  27 mer antisense strand

<400>  528
uggccuugga gaacucgaag auggggu                                           27


<210>  529
<211>  27
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  27 mer antisense strand

<400>  529
auggcucugg agaacucgaa gaugggg                                           27


<210>  530
<211>  27
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  27 mer antisense strand

<400>  530
caugguccug gagaacucga agauggg                                           27


<210>  531
<211>  27
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  27 mer antisense strand

<400>  531
ucaugucccu ggagaacucg aagaugg                                           27


<210>  532
<211>  27
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  27 mer antisense strand

<400>  532
uucauugccc uggagaacuc gaagaug                                           27


<210>  533
<211>  27
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  27 mer antisense strand

<400>  533
auucauggcc cuggagaacu cgaagau                                           27


<210>  534
<211>  27
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  27 mer antisense strand

<400>  534
cauucuuggc ccuggagaac ucgaaga                                           27


<210>  535
<211>  27
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  27 mer antisense strand

<400>  535
ucauuuaugg cccuggagaa cucgaag                                           27


<210>  536
<211>  27
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  27 mer antisense strand

<400>  536
cucauucaug gcccuggaga acucgaa                                           27


<210>  537
<211>  27
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  27 mer antisense strand

<400>  537
gcucauucau ggcccuggag aacucga                                           27


<210>  538
<211>  27
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  27 mer antisense strand

<400>  538
agcucuuuca uggcccugga gaacucg                                           27


<210>  539
<211>  27
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  27 mer antisense strand

<400>  539
cagcuuauuc auggcccugg agaacuc                                           27


<210>  540
<211>  27
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  27 mer antisense strand

<400>  540
ugcaguucau ucauggcccu ggagaac                                           27


<210>  541
<211>  27
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  27 mer antisense strand

<400>  541
uugcaucuca uucauggccc uggagaa                                           27


<210>  542
<211>  27
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  27 mer antisense strand

<400>  542
guugcugcuc auucauggcc cuggaga                                           27


<210>  543
<211>  27
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  27 mer antisense strand

<400>  543
aguuguagcu cauucauggc ccuggag                                           27


<210>  544
<211>  27
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  27 mer antisense strand

<400>  544
gaguuucagc ucauucaugg cccugga                                           27


<210>  545
<211>  27
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  27 mer antisense strand

<400>  545
ugaguugcag cucauucaug gcccugg                                           27


<210>  546
<211>  27
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  27 mer antisense strand

<400>  546
uugaguugca gcucauucau ggcccug                                           27


<210>  547
<211>  27
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  27 mer antisense strand

<400>  547
auugauuugc agcucauuca uggcccu                                           27


<210>  548
<211>  27
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  27 mer antisense strand

<400>  548
cauuguguug cagcucauuc auggccc                                           27


<210>  549
<211>  27
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  27 mer antisense strand

<400>  549
ucauuuaguu gcagcucauu cauggcc                                           27


<210>  550
<211>  27
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  27 mer antisense strand

<400>  550
cagaguagau gcugauagca augagca                                           27


<210>  551
<211>  27
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  27 mer antisense strand

<400>  551
gcagauaaga ugcugauagc aaugagc                                           27


<210>  552
<211>  27
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  27 mer antisense strand

<400>  552
ugcagugaag augcugauag caaugag                                           27


<210>  553
<211>  27
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  27 mer antisense strand

<400>  553
cugcauagaa gaugcugaua gcaauga                                           27


<210>  554
<211>  27
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  27 mer antisense strand

<400>  554
ucugcugaga agaugcugau agcaaug                                           27


<210>  555
<211>  27
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  27 mer antisense strand

<400>  555
gucuguagag aagaugcuga uagcaau                                           27


<210>  556
<211>  27
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  27 mer antisense strand

<400>  556
ggucuucaga gaagaugcug auagcaa                                           27


<210>  557
<211>  27
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  27 mer antisense strand

<400>  557
cggucugcag agaagaugcu gauagca                                           27


<210>  558
<211>  27
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  27 mer antisense strand

<400>  558
ccgguuugca gagaagaugc ugauagc                                           27


<210>  559
<211>  27
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  27 mer antisense strand

<400>  559
gccggucugc agagaagaug cugauag                                           27


<210>  560
<211>  27
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  27 mer antisense strand

<400>  560
ucucuuccug gagcuggucc ugcacgu                                           27


<210>  561
<211>  27
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  27 mer antisense strand

<400>  561
ccucuuuacc uggagcuggu ccugcac                                           27


<210>  562
<211>  27
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  27 mer antisense strand

<400>  562
gcagcuucuc uaccuggagc ugguccu                                           27


<210>  563
<211>  27
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  27 mer antisense strand

<400>  563
ugcagucucu cuaccuggag cuggucc                                           27


<210>  564
<211>  27
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  27 mer antisense strand

<400>  564
cugcauccuc ucuaccugga gcugguc                                           27


<210>  565
<211>  27
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  27 mer antisense strand

<400>  565
ugcuguagcc ucucuaccug gagcugg                                           27


<210>  566
<211>  27
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  27 mer antisense strand

<400>  566
gugcuucagc cucucuaccu ggagcug                                           27


<210>  567
<211>  27
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  27 mer antisense strand

<400>  567
uguguucugc agccucucua ccuggag                                           27


<210>  568
<211>  27
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  27 mer antisense strand

<400>  568
uauguuugcu gcagccucuc uaccugg                                           27


<210>  569
<211>  27
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  27 mer antisense strand

<400>  569
auaugugugc ugcagccucu cuaccug                                           27


<210>  570
<211>  27
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  27 mer antisense strand

<400>  570
cauauuugug cugcagccuc ucuaccu                                           27


<210>  571
<211>  27
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  27 mer antisense strand

<400>  571
acauaugugu gcugcagccu cucuacc                                           27


<210>  572
<211>  27
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  27 mer antisense strand

<400>  572
cacauuugug ugcugcagcc ucucuac                                           27


<210>  573
<211>  27
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  27 mer antisense strand

<400>  573
ccacauaugu gugcugcagc cucucua                                           27


<210>  574
<211>  27
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  27 mer antisense strand

<400>  574
uccacuuaug ugugcugcag ccucucu                                           27


<210>  575
<211>  27
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  27 mer antisense strand

<400>  575
uuccauauau gugugcugca gccucuc                                           27


<210>  576
<211>  27
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  27 mer antisense strand

<400>  576
cuuccucaua ugugugcugc agccucu                                           27


<210>  577
<211>  27
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  27 mer antisense strand

<400>  577
gcuucuacau augugugcug cagccuc                                           27


<210>  578
<211>  27
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  27 mer antisense strand

<400>  578
ggcuuucaca uaugugugcu gcagccu                                           27


<210>  579
<211>  27
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  27 mer antisense strand

<400>  579
gggcuuccac auaugugugc ugcagcc                                           27


<210>  580
<211>  27
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  27 mer antisense strand

<400>  580
caggguuucc acauaugugu gcugcag                                           27


<210>  581
<211>  27
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  27 mer antisense strand

<400>  581
gcaggucuuc cacauaugug ugcugca                                           27


<210>  582
<211>  27
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  27 mer antisense strand

<400>  582
ugcagugcuu ccacauaugu gugcugc                                           27


<210>  583
<211>  27
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  27 mer antisense strand

<400>  583
caugcugggc uuccacauau gugugcu                                           27


<210>  584
<211>  27
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  27 mer antisense strand

<400>  584
gcauguaggg cuuccacaua ugugugc                                           27


<210>  585
<211>  27
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  27 mer antisense strand

<400>  585
ggcauucagg gcuuccacau augugug                                           27


<210>  586
<211>  27
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  27 mer antisense strand

<400>  586
aggcaugcag ggcuuccaca uaugugu                                           27


<210>  587
<211>  27
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  27 mer antisense strand

<400>  587
uaggcuugca gggcuuccac auaugug                                           27


<210>  588
<211>  27
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  27 mer antisense strand

<400>  588
guagguaugc agggcuucca cauaugu                                           27


<210>  589
<211>  27
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  27 mer antisense strand

<400>  589
cguagucaug cagggcuucc acauaug                                           27


<210>  590
<211>  27
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  27 mer antisense strand

<400>  590
acguaugcau gcagggcuuc cacauau                                           27


<210>  591
<211>  27
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  27 mer antisense strand

<400>  591
gacguuggca ugcagggcuu ccacaua                                           27


<210>  592
<211>  27
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  27 mer antisense strand

<400>  592
agacguaggc augcagggcu uccacau                                           27


<210>  593
<211>  27
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  27 mer antisense strand

<400>  593
gagacuuagg caugcagggc uuccaca                                           27


<210>  594
<211>  27
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  27 mer antisense strand

<400>  594
ggagauguag gcaugcaggg cuuccac                                           27


<210>  595
<211>  27
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  27 mer antisense strand

<400>  595
uggagucgua ggcaugcagg gcuucca                                           27


<210>  596
<211>  27
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  27 mer antisense strand

<400>  596
auggauacgu aggcaugcag ggcuucc                                           27


<210>  597
<211>  27
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  27 mer antisense strand

<400>  597
gauggugacg uaggcaugca gggcuuc                                           27


<210>  598
<211>  27
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  27 mer antisense strand

<400>  598
ggauguagac guaggcaugc agggcuu                                           27


<210>  599
<211>  27
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  27 mer antisense strand

<400>  599
uggauugaga cguaggcaug cagggcu                                           27


<210>  600
<211>  27
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  27 mer antisense strand

<400>  600
guggauggag acguaggcau gcagggc                                           27


<210>  601
<211>  27
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  27 mer antisense strand

<400>  601
ggugguugga gacguaggca ugcaggg                                           27


<210>  602
<211>  27
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  27 mer antisense strand

<400>  602
ugguguaugg agacguaggc augcagg                                           27


<210>  603
<211>  27
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  27 mer antisense strand

<400>  603
augguugaug gagacguagg caugcag                                           27


<210>  604
<211>  27
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  27 mer antisense strand

<400>  604
gaugguggau ggagacguag gcaugca                                           27


<210>  605
<211>  27
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  27 mer antisense strand

<400>  605
ggauguugga uggagacgua ggcaugc                                           27


<210>  606
<211>  27
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  27 mer antisense strand

<400>  606
gggauugugg auggagacgu aggcaug                                           27


<210>  607
<211>  27
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  27 mer antisense strand

<400>  607
ggggauggug gauggagacg uaggcau                                           27


<210>  608
<211>  27
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  27 mer antisense strand

<400>  608
ugggguuggu ggauggagac guaggca                                           27


<210>  609
<211>  27
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  27 mer antisense strand

<400>  609
auggguaugg uggauggaga cguaggc                                           27


<210>  610
<211>  27
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  27 mer antisense strand

<400>  610
cauggugaug guggauggag acguagg                                           27


<210>  611
<211>  27
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  27 mer antisense strand

<400>  611
ucauguggau gguggaugga gacguag                                           27


<210>  612
<211>  27
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  27 mer antisense strand

<400>  612
gucauuggga ugguggaugg agacgua                                           27


<210>  613
<211>  27
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  27 mer antisense strand

<400>  613
ggucaugggg augguggaug gagacgu                                           27


<210>  614
<211>  27
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  27 mer antisense strand

<400>  614
ucgguuaugg ggauggugga uggagac                                           27


<210>  615
<211>  27
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  27 mer antisense strand

<400>  615
gucggucaug gggauggugg auggaga                                           27


<210>  616
<211>  27
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  27 mer antisense strand

<400>  616
agucguucau ggggauggug gauggag                                           27


<210>  617
<211>  27
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  27 mer antisense strand

<400>  617
cagucuguca uggggauggu ggaugga                                           27


<210>  618
<211>  27
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  27 mer antisense strand

<400>  618
ucaguugguc auggggaugg uggaugg                                           27


<210>  619
<211>  27
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  27 mer antisense strand

<400>  619
aucagucggu cauggggaug guggaug                                           27


<210>  620
<211>  27
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  27 mer antisense strand

<400>  620
caucauucgg ucauggggau gguggau                                           27


<210>  621
<211>  27
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  27 mer antisense strand

<400>  621
acaucugucg gucaugggga uggugga                                           27


<210>  622
<211>  27
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  27 mer antisense strand

<400>  622
aacauuaguc ggucaugggg auggugg                                           27


<210>  623
<211>  27
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  27 mer antisense strand

<400>  623
gaacaucagu cggucauggg gauggug                                           27


<210>  624
<211>  27
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  27 mer antisense strand

<400>  624
ggaacuucag ucggucaugg ggauggu                                           27


<210>  625
<211>  27
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  27 mer antisense strand

<400>  625
gggaauauca gucggucaug gggaugg                                           27


<210>  626
<211>  27
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  27 mer antisense strand

<400>  626
ugggaucauc agucggucau ggggaug                                           27


<210>  627
<211>  27
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  27 mer antisense strand

<400>  627
guggguacau cagucgguca uggggau                                           27


<210>  628
<211>  27
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  27 mer antisense strand

<400>  628
cgugguaaca ucagucgguc augggga                                           27


<210>  629
<211>  27
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  27 mer antisense strand

<400>  629
ccgugugaac aucagucggu caugggg                                           27


<210>  630
<211>  27
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  27 mer antisense strand

<400>  630
auccguggga acaucagucg gucaugg                                           27


<210>  631
<211>  27
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  27 mer antisense strand

<400>  631
cauccuuggg aacaucaguc ggucaug                                           27


<210>  632
<211>  27
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  27 mer antisense strand

<400>  632
gcaucugugg gaacaucagu cggucau                                           27


<210>  633
<211>  27
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  27 mer antisense strand

<400>  633
agcauucgug ggaacaucag ucgguca                                           27


<210>  634
<211>  27
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  27 mer antisense strand

<400>  634
uagcauccgu gggaacauca gucgguc                                           27


<210>  635
<211>  27
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  27 mer antisense strand

<400>  635
auuaguaucc gugggaacau cagucgg                                           27


<210>  636
<211>  27
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  27 mer antisense strand

<400>  636
cauuaucauc cgugggaaca ucagucg                                           27


<210>  637
<211>  27
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  27 mer antisense strand

<400>  637
uucauuagca uccgugggaa caucagu                                           27


<210>  638
<211>  27
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  27 mer antisense strand

<400>  638
uuucauuagc auccguggga acaucag                                           27


<210>  639
<211>  27
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  27 mer antisense strand

<400>  639
aguuuuauua gcauccgugg gaacauc                                           27


<210>  640
<211>  27
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  27 mer antisense strand

<400>  640
caguuucauu agcauccgug ggaacau                                           27


<210>  641
<211>  27
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  27 mer antisense strand

<400>  641
ccaguuucau uagcauccgu gggaaca                                           27


<210>  642
<211>  27
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  27 mer antisense strand

<400>  642
accaguuuca uuagcauccg ugggaac                                           27


<210>  643
<211>  27
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  27 mer antisense strand

<400>  643
caccauuuuc auuagcaucc gugggaa                                           27


<210>  644
<211>  27
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  27 mer antisense strand

<400>  644
ucaccuguuu cauuagcauc cguggga                                           27


<210>  645
<211>  27
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  27 mer antisense strand

<400>  645
cucacuaguu ucauuagcau ccguggg                                           27


<210>  646
<211>  27
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  27 mer antisense strand

<400>  646
gcucaucagu uucauuagca uccgugg                                           27


<210>  647
<211>  27
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  27 mer antisense strand

<400>  647
ggcucuccag uuucauuagc auccgug                                           27


<210>  648
<211>  27
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  27 mer antisense strand

<400>  648
aggcuuacca guuucauuag cauccgu                                           27


<210>  649
<211>  27
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  27 mer antisense strand

<400>  649
gaggcucacc aguuucauua gcauccg                                           27


<210>  650
<211>  27
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  27 mer antisense strand

<400>  650
cggagucuca ccaguuucau uagcauc                                           27


<210>  651
<211>  27
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  27 mer antisense strand

<400>  651
ccggaugcuc accaguuuca uuagcau                                           27


<210>  652
<211>  27
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  27 mer antisense strand

<400>  652
uccgguggcu caccaguuuc auuagca                                           27


<210>  653
<211>  27
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  27 mer antisense strand

<400>  653
guccguaggc ucaccaguuu cauuagc                                           27


<210>  654
<211>  27
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  27 mer antisense strand

<400>  654
gguccugagg cucaccaguu ucauuag                                           27


<210>  655
<211>  27
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  27 mer antisense strand

<400>  655
gggucuggag gcucaccagu uucauua                                           27


<210>  656
<211>  27
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  27 mer antisense strand

<400>  656
aggguucgga ggcucaccag uuucauu                                           27


<210>  657
<211>  27
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  27 mer antisense strand

<400>  657
ucagguuccg gaggcucacc aguuuca                                           27


<210>  658
<211>  27
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  27 mer antisense strand

<400>  658
cucagugucc ggaggcucac caguuuc                                           27


<210>  659
<211>  27
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  27 mer antisense strand

<400>  659
ugcucugggu ccggaggcuc accaguu                                           27


<210>  660
<211>  27
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  27 mer antisense strand

<400>  660
ugaguugacg cugcucaggg uccggag                                           27


<210>  661
<211>  27
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  27 mer antisense strand

<400>  661
ucugauugga cgcugcucag gguccgg                                           27


<210>  662
<211>  27
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  27 mer antisense strand

<400>  662
cucugugugg acgcugcuca ggguccg                                           27


<210>  663
<211>  27
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  27 mer antisense strand

<400>  663
gcucuuagug gacgcugcuc agggucc                                           27


<210>  664
<211>  27
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  27 mer antisense strand

<400>  664
ugcucugagu ggacgcugcu caggguc                                           27


<210>  665
<211>  27
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  27 mer antisense strand

<400>  665
uugcuuugag uggacgcugc ucagggu                                           27


<210>  666
<211>  27
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  27 mer antisense strand

<400>  666
cuugcucuga guggacgcug cucaggg                                           27


<210>  667
<211>  27
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  27 mer antisense strand

<400>  667
acuuguucug aguggacgcu gcucagg                                           27


<210>  668
<211>  27
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  27 mer antisense strand

<400>  668
cacuuucucu gaguggacgc ugcucag                                           27


<210>  669
<211>  27
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  27 mer antisense strand

<400>  669
acacuugcuc ugaguggacg cugcuca                                           27


<210>  670
<211>  27
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  27 mer antisense strand

<400>  670
aacacuugcu cugaguggac gcugcuc                                           27


<210>  671
<211>  27
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  27 mer antisense strand

<400>  671
aaacauuugc ucugagugga cgcugcu                                           27


<210>  672
<211>  27
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  27 mer antisense strand

<400>  672
caaacucuug cucugagugg acgcugc                                           27


<210>  673
<211>  27
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  27 mer antisense strand

<400>  673
gcaaauacuu gcucugagug gacgcug                                           27


<210>  674
<211>  27
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  27 mer antisense strand

<400>  674
ugcaaucacu ugcucugagu ggacgcu                                           27


<210>  675
<211>  27
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  27 mer antisense strand

<400>  675
gugcauacac uugcucugag uggacgc                                           27


<210>  676
<211>  27
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  27 mer antisense strand

<400>  676
agugcuaaca cuugcucuga guggacg                                           27


<210>  677
<211>  27
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  27 mer antisense strand

<400>  677
caguguaaac acuugcucug aguggac                                           27


<210>  678
<211>  27
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  27 mer antisense strand

<400>  678
cgcagugcaa acacuugcuc ugagugg                                           27


<210>  679
<211>  27
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  27 mer antisense strand

<400>  679
acgcauugca aacacuugcu cugagug                                           27


<210>  680
<211>  27
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  27 mer antisense strand

<400>  680
gacgcugugc aaacacuugc ucugagu                                           27


<210>  681
<211>  27
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  27 mer antisense strand

<400>  681
agacguagug caaacacuug cucugag                                           27


<210>  682
<211>  27
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  27 mer antisense strand

<400>  682
cagacucagu gcaaacacuu gcucuga                                           27


<210>  683
<211>  27
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  27 mer antisense strand

<400>  683
gcagaugcag ugcaaacacu ugcucug                                           27


<210>  684
<211>  27
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  27 mer antisense strand

<400>  684
ugcagucgca gugcaaacac uugcucu                                           27


<210>  685
<211>  27
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  27 mer antisense strand

<400>  685
cugcauacgc agugcaaaca cuugcuc                                           27


<210>  686
<211>  27
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  27 mer antisense strand

<400>  686
ccugcugacg cagugcaaac acuugcu                                           27


<210>  687
<211>  27
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  27 mer antisense strand

<400>  687
uccuguagac gcagugcaaa cacuugc                                           27


<210>  688
<211>  27
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  27 mer antisense strand

<400>  688
guccuucaga cgcagugcaa acacuug                                           27


<210>  689
<211>  27
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  27 mer antisense strand

<400>  689
uguccugcag acgcagugca aacacuu                                           27


<210>  690
<211>  27
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  27 mer antisense strand

<400>  690
uugucuugca gacgcagugc aaacacu                                           27


<210>  691
<211>  27
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  27 mer antisense strand

<400>  691
uuuguucugc agacgcagug caaacac                                           27


<210>  692
<211>  27
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  27 mer antisense strand

<400>  692
uuuuguccug cagacgcagu gcaaaca                                           27


<210>  693
<211>  27
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  27 mer antisense strand

<400>  693
uuuuuuuccu gcagacgcag ugcaaac                                           27


<210>  694
<211>  27
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  27 mer antisense strand

<400>  694
cuuuuugucc ugcagacgca gugcaaa                                           27


<210>  695
<211>  27
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  27 mer antisense strand

<400>  695
gcuuuuuguc cugcagacgc agugcaa                                           27


<210>  696
<211>  27
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  27 mer antisense strand

<400>  696
agcuuuuugu ccugcagacg cagugca                                           27


<210>  697
<211>  27
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  27 mer antisense strand

<400>  697
gagcuuuuug uccugcagac gcagugc                                           27


<210>  698
<211>  27
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  27 mer antisense strand

<400>  698
ggagcuuuuu guccugcaga cgcagug                                           27


<210>  699
<211>  27
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  27 mer antisense strand

<400>  699
gggaguuuuu uguccugcag acgcagu                                           27


<210>  700
<211>  27
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  27 mer antisense strand

<400>  700
ugggaucuuu uuguccugca gacgcag                                           27


<210>  701
<211>  27
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  27 mer antisense strand

<400>  701
gugggugcuu uuuguccugc agacgca                                           27


<210>  702
<211>  27
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  27 mer antisense strand

<400>  702
ggugguagcu uuuuguccug cagacgc                                           27


<210>  703
<211>  27
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  27 mer antisense strand

<400>  703
cggugugagc uuuuuguccu gcagacg                                           27


<210>  704
<211>  27
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  27 mer antisense strand

<400>  704
gcgguuggag cuuuuugucc ugcagac                                           27


<210>  705
<211>  27
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  27 mer antisense strand

<400>  705
cagcguuggg agcuuuuugu ccugcag                                           27


<210>  706
<211>  27
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  27 mer antisense strand

<400>  706
gcagcugugg gagcuuuuug uccugca                                           27


<210>  707
<211>  27
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  27 mer antisense strand

<400>  707
agcaguggug ggagcuuuuu guccugc                                           27


<210>  708
<211>  27
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  27 mer antisense strand

<400>  708
gagcaucggu gggagcuuuu uguccug                                           27


<210>  709
<211>  27
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  27 mer antisense strand

<400>  709
gagaguagcg gugggagcuu uuugucc                                           27


<210>  710
<211>  27
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  27 mer antisense strand

<400>  710
agagaucagc ggugggagcu uuuuguc                                           27


<210>  711
<211>  27
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  27 mer antisense strand

<400>  711
cagagugcag cggugggagc uuuuugu                                           27


<210>  712
<211>  27
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  27 mer antisense strand

<400>  712
ucagauagca gcggugggag cuuuuug                                           27


<210>  713
<211>  27
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  27 mer antisense strand

<400>  713
cucagugagc agcgguggga gcuuuuu                                           27


<210>  714
<211>  27
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  27 mer antisense strand

<400>  714
ucucauagag cagcgguggg agcuuuu                                           27


<210>  715
<211>  27
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  27 mer antisense strand

<400>  715
aucucugaga gcagcggugg gagcuuu                                           27


<210>  716
<211>  27
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  27 mer antisense strand

<400>  716
gaucuuagag agcagcggug ggagcuu                                           27


<210>  717
<211>  27
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  27 mer antisense strand

<400>  717
cagauuucag agagcagcgg ugggagc                                           27


<210>  718
<211>  27
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  27 mer antisense strand

<400>  718
cccaguucuc agagagcagc gguggga                                           27


<210>  719
<211>  27
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  27 mer antisense strand

<400>  719
ucccauaucu cagagagcag cgguggg                                           27


<210>  720
<211>  27
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  27 mer antisense strand

<400>  720
cauccuagau cucagagagc agcggug                                           27


<210>  721
<211>  27
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  27 mer antisense strand

<400>  721
acaucucaga ucucagagag cagcggu                                           27


<210>  722
<211>  27
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  27 mer antisense strand

<400>  722
cacauuccag aucucagaga gcagcgg                                           27


<210>  723
<211>  27
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  27 mer antisense strand

<400>  723
gugcauaucc cagaucucag agagcag                                           27


<210>  724
<211>  27
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  27 mer antisense strand

<400>  724
ucguguacau cccagaucuc agagagc                                           27


<210>  725
<211>  27
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  27 mer antisense strand

<400>  725
uucguucaca ucccagaucu cagagag                                           27


<210>  726
<211>  27
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  27 mer antisense strand

<400>  726
auucgugcac aucccagauc ucagaga                                           27


<210>  727
<211>  27
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  27 mer antisense strand

<400>  727
cauucuugca caucccagau cucagag                                           27


<210>  728
<211>  27
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  27 mer antisense strand

<400>  728
ucauuugugc acaucccaga ucucaga                                           27


<210>  729
<211>  27
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  27 mer antisense strand

<400>  729
gucauucgug cacaucccag aucucag                                           27


<210>  730
<211>  27
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  27 mer antisense strand

<400>  730
agucauucgu gcacauccca gaucuca                                           27


<210>  731
<211>  27
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  27 mer antisense strand

<400>  731
cagucuuucg ugcacauccc agaucuc                                           27


<210>  732
<211>  27
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  27 mer antisense strand

<400>  732
acaguuauuc gugcacaucc cagaucu                                           27


<210>  733
<211>  27
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  27 mer antisense strand

<400>  733
aacagucauu cgugcacauc ccagauc                                           27


<210>  734
<211>  27
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  27 mer antisense strand

<400>  734
gaacauucau ucgugcacau cccagau                                           27


<210>  735
<211>  27
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  27 mer antisense strand

<400>  735
agaacuguca uucgugcaca ucccaga                                           27


<210>  736
<211>  27
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  27 mer antisense strand

<400>  736
cagaauaguc auucgugcac aucccag                                           27


<210>  737
<211>  27
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  27 mer antisense strand

<400>  737
acagaucagu cauucgugca cauccca                                           27


<210>  738
<211>  27
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  27 mer antisense strand

<400>  738
gacaguacag ucauucgugc acauccc                                           27


<210>  739
<211>  27
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  27 mer antisense strand

<400>  739
uuccauuucu aggaggcagc caccagg                                           27


<210>  740
<211>  27
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  27 mer antisense strand

<400>  740
guuccucuuc uaggaggcag ccaccag                                           27


<210>  741
<211>  27
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  27 mer antisense strand

<400>  741
uguucuacuu cuaggaggca gccacca                                           27


<210>  742
<211>  27
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  27 mer antisense strand

<400>  742
cuguuucacu ucuaggaggc agccacc                                           27


<210>  743
<211>  27
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  27 mer antisense strand

<400>  743
ucuguuccac uucuaggagg cagccac                                           27


<210>  744
<211>  27
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  27 mer antisense strand

<400>  744
gucuguucca cuucuaggag gcagcca                                           27


<210>  745
<211>  27
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  27 mer antisense strand

<400>  745
agucuuuucc acuucuagga ggcagcc                                           27


<210>  746
<211>  27
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  27 mer antisense strand

<400>  746
cagucuguuc cacuucuagg aggcagc                                           27


<210>  747
<211>  27
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  27 mer antisense strand

<400>  747
ucaguuuguu ccacuucuag gaggcag                                           27


<210>  748
<211>  27
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  27 mer antisense strand

<400>  748
cucagucugu uccacuucua ggaggca                                           27


<210>  749
<211>  27
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  27 mer antisense strand

<400>  749
ucucauucug uuccacuucu aggaggc                                           27


<210>  750
<211>  27
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  27 mer antisense strand

<400>  750
uucucugucu guuccacuuc uaggagg                                           27


<210>  751
<211>  27
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  27 mer antisense strand

<400>  751
cuucuuaguc uguuccacuu cuaggag                                           27


<210>  752
<211>  27
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  27 mer antisense strand

<400>  752
ccuucucagu cuguuccacu ucuagga                                           27


<210>  753
<211>  27
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  27 mer antisense strand

<400>  753
gcccuucuca gucuguucca cuucuag                                           27


<210>  754
<211>  27
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  27 mer antisense strand

<400>  754
auguuugccc uucucagucu guuccac                                           27


<210>  755
<211>  27
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  27 mer antisense strand

<400>  755
gaauguuugc ccuucucagu cuguucc                                           27


<210>  756
<211>  27
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  27 mer antisense strand

<400>  756
ggaauuuuug cccuucucag ucuguuc                                           27


<210>  757
<211>  27
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  27 mer antisense strand

<400>  757
aggaauguuu gcccuucuca gucuguu                                           27


<210>  758
<211>  27
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  27 mer antisense strand

<400>  758
caggauuguu ugcccuucuc agucugu                                           27


<210>  759
<211>  27
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  27 mer antisense strand

<400>  759
ccagguaugu uugcccuucu cagucug                                           27


<210>  760
<211>  27
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  27 mer antisense strand

<400>  760
cccaguaaug uuugcccuuc ucagucu                                           27


<210>  761
<211>  27
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  27 mer antisense strand

<400>  761
ucccaugaau guuugcccuu cucaguc                                           27


<210>  762
<211>  27
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  27 mer antisense strand

<400>  762
cucccuggaa uguuugcccu ucucagu                                           27


<210>  763
<211>  27
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  27 mer antisense strand

<400>  763
gcuccuagga auguuugccc uucucag                                           27


<210>  764
<211>  27
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  27 mer antisense strand

<400>  764
uuugauucuc uuuuaaugcc acgggag                                           27


<210>  765
<211>  27
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  27 mer antisense strand

<400>  765
cuuugucucu cuuuuaaugc cacggga                                           27


<210>  766
<211>  27
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  27 mer antisense strand

<400>  766
ccuuuuacuc ucuuuuaaug ccacggg                                           27


<210>  767
<211>  27
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  27 mer antisense strand

<400>  767
cccuuugacu cucuuuuaau gccacgg                                           27


<210>  768
<211>  27
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  27 mer antisense strand

<400>  768
acccuuugac ucucuuuuaa ugccacg                                           27


<210>  769
<211>  36
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  36 mer sense strand

<400>  769
guguccuguc agaagaacaa gcagccgaaa ggcugc                                 36


<210>  770
<211>  36
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  36 mer sense strand

<400>  770
guccugucag aagaacagaa gcagccgaaa ggcugc                                 36


<210>  771
<211>  36
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  36 mer sense strand

<400>  771
ccugucagaa gaacagauca gcagccgaaa ggcugc                                 36


<210>  772
<211>  36
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  36 mer sense strand

<400>  772
cugucagaag aacagaucca gcagccgaaa ggcugc                                 36


<210>  773
<211>  36
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  36 mer sense strand

<400>  773
ugucagaaga acagauccga gcagccgaaa ggcugc                                 36


<210>  774
<211>  36
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  36 mer sense strand

<400>  774
gaaacugaag cggcaagaga gcagccgaaa ggcugc                                 36


<210>  775
<211>  36
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  36 mer sense strand

<400>  775
gugaugcuuc uggagacaua gcagccgaaa ggcugc                                 36


<210>  776
<211>  36
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  36 mer sense strand

<400>  776
ggagugagag uaucaccuua gcagccgaaa ggcugc                                 36


<210>  777
<211>  36
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  36 mer sense strand

<400>  777
agaguaucac cuuccucaaa gcagccgaaa ggcugc                                 36


<210>  778
<211>  36
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  36 mer sense strand

<400>  778
aucaccuucc ucaaggauua gcagccgaaa ggcugc                                 36


<210>  779
<211>  36
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  36 mer sense strand

<400>  779
ucaccuuccu caaggauuua gcagccgaaa ggcugc                                 36


<210>  780
<211>  36
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  36 mer sense strand

<400>  780
caccuuccuc aaggauuuca gcagccgaaa ggcugc                                 36


<210>  781
<211>  36
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  36 mer sense strand

<400>  781
accuuccuca aggauuucaa gcagccgaaa ggcugc                                 36


<210>  782
<211>  36
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  36 mer sense strand

<400>  782
ccuuccucaa ggauuucaga gcagccgaaa ggcugc                                 36


<210>  783
<211>  36
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  36 mer sense strand

<400>  783
cuuccucaag gauuucagua gcagccgaaa ggcugc                                 36


<210>  784
<211>  36
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  36 mer sense strand

<400>  784
uuccucaagg auuucaguua gcagccgaaa ggcugc                                 36


<210>  785
<211>  36
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  36 mer sense strand

<400>  785
ccucaaggau uucaguuaua gcagccgaaa ggcugc                                 36


<210>  786
<211>  36
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  36 mer sense strand

<400>  786
cucaaggauu ucaguuauaa gcagccgaaa ggcugc                                 36


<210>  787
<211>  36
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  36 mer sense strand

<400>  787
ucaaggauuu caguuauaaa gcagccgaaa ggcugc                                 36


<210>  788
<211>  36
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  36 mer sense strand

<400>  788
caaggauuuc aguuauaaca gcagccgaaa ggcugc                                 36


<210>  789
<211>  36
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  36 mer sense strand

<400>  789
aaggauuuca guuauaacca gcagccgaaa ggcugc                                 36


<210>  790
<211>  36
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  36 mer sense strand

<400>  790
aggauuucag uuauaaccga gcagccgaaa ggcugc                                 36


<210>  791
<211>  36
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  36 mer sense strand

<400>  791
ggauuucagu uauaaccgga gcagccgaaa ggcugc                                 36


<210>  792
<211>  36
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  36 mer sense strand

<400>  792
aguuauaacc gggaagacua gcagccgaaa ggcugc                                 36


<210>  793
<211>  36
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  36 mer sense strand

<400>  793
cagggcugca aguggaauua gcagccgaaa ggcugc                                 36


<210>  794
<211>  36
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  36 mer sense strand

<400>  794
cugcaagugg aauucaucaa gcagccgaaa ggcugc                                 36


<210>  795
<211>  36
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  36 mer sense strand

<400>  795
ugcaagugga auucaucaaa gcagccgaaa ggcugc                                 36


<210>  796
<211>  36
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  36 mer sense strand

<400>  796
gcaaguggaa uucaucaaca gcagccgaaa ggcugc                                 36


<210>  797
<211>  36
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  36 mer sense strand

<400>  797
caaguggaau ucaucaacca gcagccgaaa ggcugc                                 36


<210>  798
<211>  36
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  36 mer sense strand

<400>  798
guggaauuca ucaaccccaa gcagccgaaa ggcugc                                 36


<210>  799
<211>  36
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  36 mer sense strand

<400>  799
uggaauucau caaccccaua gcagccgaaa ggcugc                                 36


<210>  800
<211>  36
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  36 mer sense strand

<400>  800
gaauucauca accccaucua gcagccgaaa ggcugc                                 36


<210>  801
<211>  36
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  36 mer sense strand

<400>  801
aauucaucaa ccccaucuua gcagccgaaa ggcugc                                 36


<210>  802
<211>  36
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  36 mer sense strand

<400>  802
ugcagcacac auauguggaa gcagccgaaa ggcugc                                 36


<210>  803
<211>  36
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  36 mer sense strand

<400>  803
gcacacauau guggaagcca gcagccgaaa ggcugc                                 36


<210>  804
<211>  36
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  36 mer sense strand

<400>  804
caugaccgac ugauguucca gcagccgaaa ggcugc                                 36


<210>  805
<211>  36
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  36 mer sense strand

<400>  805
cgacugaugu ucccacggaa gcagccgaaa ggcugc                                 36


<210>  806
<211>  36
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  36 mer sense strand

<400>  806
gacugauguu cccacggaua gcagccgaaa ggcugc                                 36


<210>  807
<211>  36
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  36 mer sense strand

<400>  807
cugauguucc cacggaugca gcagccgaaa ggcugc                                 36


<210>  808
<211>  36
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  36 mer sense strand

<400>  808
gauguuccca cggaugcuaa gcagccgaaa ggcugc                                 36


<210>  809
<211>  36
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  36 mer sense strand

<400>  809
auguucccac ggaugcuaaa gcagccgaaa ggcugc                                 36


<210>  810
<211>  36
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  36 mer sense strand

<400>  810
ggaugcuaau gaaacuggua gcagccgaaa ggcugc                                 36


<210>  811
<211>  36
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  36 mer sense strand

<400>  811
augcuaauga aacuggugaa gcagccgaaa ggcugc                                 36


<210>  812
<211>  36
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  36 mer sense strand

<400>  812
cacucagagc aaguguuuga gcagccgaaa ggcugc                                 36


<210>  813
<211>  36
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  36 mer sense strand

<400>  813
augugcacga augacuguua gcagccgaaa ggcugc                                 36


<210>  814
<211>  36
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  36 mer sense strand

<400>  814
ugugcacgaa ugacuguuca gcagccgaaa ggcugc                                 36


<210>  815
<211>  36
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  36 mer sense strand

<400>  815
gugcacgaau gacuguucua gcagccgaaa ggcugc                                 36


<210>  816
<211>  36
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  36 mer sense strand

<400>  816
uagaagugga acagacugaa gcagccgaaa ggcugc                                 36


<210>  817
<211>  36
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  36 mer sense strand

<400>  817
gaaguggaac agacugagaa gcagccgaaa ggcugc                                 36


<210>  818
<211>  36
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  36 mer sense strand

<400>  818
aaguggaaca gacugagaaa gcagccgaaa ggcugc                                 36


<210>  819
<211>  36
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  36 mer sense strand

<400>  819
aguggaacag acugagaaga gcagccgaaa ggcugc                                 36


<210>  820
<211>  36
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  36 mer sense strand

<400>  820
guggaacaga cugagaagga gcagccgaaa ggcugc                                 36


<210>  821
<211>  36
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  36 mer sense strand

<400>  821
uggaacagac ugagaaggga gcagccgaaa ggcugc                                 36


<210>  822
<211>  36
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  36 mer sense strand

<400>  822
gaacagacug agaagggcaa gcagccgaaa ggcugc                                 36


<210>  823
<211>  33
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  36 mer sense strand

<400>  823
uccucaagga uuucaguuaa gcagccgggc ugc                                    33


<210>  824
<211>  33
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  36 mer sense strand

<400>  824
caguuauaac cgggaagaca gcagccgggc ugc                                    33


<210>  825
<211>  33
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  36 mer sense strand

<400>  825
uauaaccggg aagacuuuga gcagccgggc ugc                                    33


<210>  826
<211>  33
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  36 mer sense strand

<400>  826
caaagcaggg cugcaaguga gcagccgggc ugc                                    33


<210>  827
<211>  33
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  36 mer sense strand

<400>  827
ggcugcaagu ggaauucaua gcagccgggc ugc                                    33


<210>  828
<211>  33
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  36 mer sense strand

<400>  828
aguggaauuc aucaacccca gcagccgggc ugc                                    33


<210>  829
<211>  33
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  36 mer sense strand

<400>  829
auucaucaac cccaucuuca gcagccgggc ugc                                    33


<210>  830
<211>  33
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  36 mer sense strand

<400>  830
uucaucaacc ccaucuucga gcagccgggc ugc                                    33


<210>  831
<211>  33
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  36 mer sense strand

<400>  831
ugcaugccua cgucuccaua gcagccgggc ugc                                    33


<210>  832
<211>  33
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  36 mer sense strand

<400>  832
ugccuacguc uccauccaca gcagccgggc ugc                                    33


<210>  833
<211>  33
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  36 mer sense strand

<400>  833
uacgucucca uccaccauca gcagccgggc ugc                                    33


<210>  834
<211>  33
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  36 mer sense strand

<400>  834
cgucuccauc caccauccca gcagccgggc ugc                                    33


<210>  835
<211>  33
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  36 mer sense strand

<400>  835
auccaccauc cccaugacca gcagccgggc ugc                                    33


<210>  836
<211>  33
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  36 mer sense strand

<400>  836
ccgacugaug uucccacgga gcagccgggc ugc                                    33


<210>  837
<211>  33
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  36 mer sense strand

<400>  837
cccacggaug cuaaugaaaa gcagccgggc ugc                                    33


<210>  838
<211>  33
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  36 mer sense strand

<400>  838
cggaugcuaa ugaaacugga gcagccgggc ugc                                    33


<210>  839
<211>  33
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  36 mer sense strand

<400>  839
gaugcuaaug aaacugguga gcagccgggc ugc                                    33


<210>  840
<211>  33
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  36 mer sense strand

<400>  840
cuaaugaaac uggugagcca gcagccgggc ugc                                    33


<210>  841
<211>  33
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  36 mer sense strand

<400>  841
agcagcgucc acucagagca gcagccgggc ugc                                    33


<210>  842
<211>  33
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  36 mer sense strand

<400>  842
cagcguccac ucagagcaaa gcagccgggc ugc                                    33


<210>  843
<211>  33
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  36 mer sense strand

<400>  843
agcguccacu cagagcaaga gcagccgggc ugc                                    33


<210>  844
<211>  33
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  36 mer sense strand

<400>  844
caaguguuug cacugcguca gcagccgggc ugc                                    33


<210>  845
<211>  33
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  36 mer sense strand

<400>  845
aguguuugca cugcgucuga gcagccgggc ugc                                    33


<210>  846
<211>  33
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  36 mer sense strand

<400>  846
cugcgucugc aggacaaaaa gcagccgggc ugc                                    33


<210>  847
<211>  33
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  36 mer sense strand

<400>  847
caggacaaaa agcucccaca gcagccgggc ugc                                    33


<210>  848
<211>  33
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  36 mer sense strand

<400>  848
ucugagaucu gggaugugca gcagccgggc ugc                                    33


<210>  849
<211>  33
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  36 mer sense strand

<400>  849
gaucugggau gugcacgaaa gcagccgggc ugc                                    33


<210>  850
<211>  33
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  36 mer sense strand

<400>  850
aucugggaug ugcacgaaua gcagccgggc ugc                                    33


<210>  851
<211>  33
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  36 mer sense strand

<400>  851
ucugggaugu gcacgaauga gcagccgggc ugc                                    33


<210>  852
<211>  33
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  36 mer sense strand

<400>  852
ugccuccuag aaguggaaca gcagccgggc ugc                                    33


<210>  853
<211>  33
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  36 mer sense strand

<400>  853
agaaguggaa cagacugaga gcagccgggc ugc                                    33


<210>  854
<211>  33
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  36 mer sense strand

<400>  854
acugagaagg gcaaacauua gcagccgggc ugc                                    33


<210>  855
<211>  33
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  36 mer sense strand

<400>  855
guggcauuaa aagagaguca gcagccgggc ugc                                    33


<210>  856
<211>  33
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  36 mer sense strand

<400>  856
uggcauuaaa agagagucaa gcagccgggc ugc                                    33


<210>  857
<211>  22
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  22 mer antisense strand

<400>  857
uuguucuucu gacaggacac gg                                                22


<210>  858
<211>  22
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  22 mer antisense strand

<400>  858
uucuguucuu cugacaggac gg                                                22


<210>  859
<211>  22
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  22 mer antisense strand

<400>  859
ugaucuguuc uucugacagg gg                                                22


<210>  860
<211>  22
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  22 mer antisense strand

<400>  860
uggaucuguu cuucugacag gg                                                22


<210>  861
<211>  22
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  22 mer antisense strand

<400>  861
ucggaucugu ucuucugaca gg                                                22


<210>  862
<211>  22
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  22 mer antisense strand

<400>  862
ucucuugccg cuucaguuuc gg                                                22


<210>  863
<211>  22
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  22 mer antisense strand

<400>  863
uaugucucca gaagcaucac gg                                                22


<210>  864
<211>  22
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  22 mer antisense strand

<400>  864
uaaggugaua cucucacucc gg                                                22


<210>  865
<211>  22
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  22 mer antisense strand

<400>  865
uuugaggaag gugauacucu gg                                                22


<210>  866
<211>  22
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  22 mer antisense strand

<400>  866
uaauccuuga ggaaggugau gg                                                22


<210>  867
<211>  22
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  22 mer antisense strand

<400>  867
uaaauccuug aggaagguga gg                                                22


<210>  868
<211>  22
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  22 mer antisense strand

<400>  868
ugaaauccuu gaggaaggug gg                                                22


<210>  869
<211>  22
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  22 mer antisense strand

<400>  869
uugaaauccu ugaggaaggu gg                                                22


<210>  870
<211>  22
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  22 mer antisense strand

<400>  870
ucugaaaucc uugaggaagg gg                                                22


<210>  871
<211>  22
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  22 mer antisense strand

<400>  871
uacugaaauc cuugaggaag gg                                                22


<210>  872
<211>  22
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  22 mer antisense strand

<400>  872
uaacugaaau ccuugaggaa gg                                                22


<210>  873
<211>  22
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  22 mer antisense strand

<400>  873
uauaacugaa auccuugagg gg                                                22


<210>  874
<211>  22
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  22 mer antisense strand

<400>  874
uuauaacuga aauccuugag gg                                                22


<210>  875
<211>  22
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  22 mer antisense strand

<400>  875
uuuauaacug aaauccuuga gg                                                22


<210>  876
<211>  22
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  22 mer antisense strand

<400>  876
uguuauaacu gaaauccuug gg                                                22


<210>  877
<211>  22
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  22 mer antisense strand

<400>  877
ugguuauaac ugaaauccuu gg                                                22


<210>  878
<211>  22
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  22 mer antisense strand

<400>  878
ucgguuauaa cugaaauccu gg                                                22


<210>  879
<211>  22
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  22 mer antisense strand

<400>  879
uccgguuaua acugaaaucc gg                                                22


<210>  880
<211>  22
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  22 mer antisense strand

<400>  880
uagucuuccc gguuauaacu gg                                                22


<210>  881
<211>  22
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  22 mer antisense strand

<400>  881
uaauuccacu ugcagcccug gg                                                22


<210>  882
<211>  22
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  22 mer antisense strand

<400>  882
uugaugaauu ccacuugcag gg                                                22


<210>  883
<211>  22
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  22 mer antisense strand

<400>  883
uuugaugaau uccacuugca gg                                                22


<210>  884
<211>  22
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  22 mer antisense strand

<400>  884
uguugaugaa uuccacuugc gg                                                22


<210>  885
<211>  22
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  22 mer antisense strand

<400>  885
ugguugauga auuccacuug gg                                                22


<210>  886
<211>  22
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  22 mer antisense strand

<400>  886
uugggguuga ugaauuccac gg                                                22


<210>  887
<211>  22
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  22 mer antisense strand

<400>  887
uaugggguug augaauucca gg                                                22


<210>  888
<211>  22
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  22 mer antisense strand

<400>  888
uagauggggu ugaugaauuc gg                                                22


<210>  889
<211>  22
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  22 mer antisense strand

<400>  889
uaagaugggg uugaugaauu gg                                                22


<210>  890
<211>  22
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  22 mer antisense strand

<400>  890
uuccacauau gugugcugca gg                                                22


<210>  891
<211>  22
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  22 mer antisense strand

<400>  891
uggcuuccac auaugugugc gg                                                22


<210>  892
<211>  22
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  22 mer antisense strand

<400>  892
uggaacauca gucggucaug gg                                                22


<210>  893
<211>  22
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  22 mer antisense strand

<400>  893
uuccguggga acaucagucg gg                                                22


<210>  894
<211>  22
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  22 mer antisense strand

<400>  894
uauccguggg aacaucaguc gg                                                22


<210>  895
<211>  22
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  22 mer antisense strand

<400>  895
ugcauccgug ggaacaucag gg                                                22


<210>  896
<211>  22
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  22 mer antisense strand

<400>  896
uuagcauccg ugggaacauc gg                                                22


<210>  897
<211>  22
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  22 mer antisense strand

<400>  897
uuuagcaucc gugggaacau gg                                                22


<210>  898
<211>  22
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  22 mer antisense strand

<400>  898
uaccaguuuc auuagcaucc gg                                                22


<210>  899
<211>  22
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  22 mer antisense strand

<400>  899
uucaccaguu ucauuagcau gg                                                22


<210>  900
<211>  22
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  22 mer antisense strand

<400>  900
ucaaacacuu gcucugagug gg                                                22


<210>  901
<211>  22
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  22 mer antisense strand

<400>  901
uaacagucau ucgugcacau gg                                                22


<210>  902
<211>  22
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  22 mer antisense strand

<400>  902
ugaacaguca uucgugcaca gg                                                22


<210>  903
<211>  22
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  22 mer antisense strand

<400>  903
uagaacaguc auucgugcac gg                                                22


<210>  904
<211>  22
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  22 mer antisense strand

<400>  904
uucagucugu uccacuucua gg                                                22


<210>  905
<211>  22
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  22 mer antisense strand

<400>  905
uucucagucu guuccacuuc gg                                                22


<210>  906
<211>  22
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  22 mer antisense strand

<400>  906
uuucucaguc uguuccacuu gg                                                22


<210>  907
<211>  22
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  22 mer antisense strand

<400>  907
ucuucucagu cuguuccacu gg                                                22


<210>  908
<211>  22
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  22 mer antisense strand

<400>  908
uccuucucag ucuguuccac gg                                                22


<210>  909
<211>  22
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  22 mer antisense strand

<400>  909
ucccuucuca gucuguucca gg                                                22


<210>  910
<211>  22
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  22 mer antisense strand

<400>  910
uugcccuucu cagucuguuc gg                                                22


<210>  911
<211>  22
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  22 mer antisense strand

<400>  911
uuaacugaaa uccuugagga gg                                                22


<210>  912
<211>  22
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  22 mer antisense strand

<400>  912
ugucuucccg guuauaacug gg                                                22


<210>  913
<211>  22
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  22 mer antisense strand

<400>  913
ucaaagucuu cccgguuaua gg                                                22


<210>  914
<211>  22
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  22 mer antisense strand

<400>  914
ucacuugcag cccugcuuug gg                                                22


<210>  915
<211>  22
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  22 mer antisense strand

<400>  915
uaugaauucc acuugcagcc gg                                                22


<210>  916
<211>  22
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  22 mer antisense strand

<400>  916
ugggguugau gaauuccacu gg                                                22


<210>  917
<211>  22
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  22 mer antisense strand

<400>  917
ugaagauggg guugaugaau gg                                                22


<210>  918
<211>  22
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  22 mer antisense strand

<400>  918
ucgaagaugg gguugaugaa gg                                                22


<210>  919
<211>  22
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  22 mer antisense strand

<400>  919
uauggagacg uaggcaugca gg                                                22


<210>  920
<211>  22
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  22 mer antisense strand

<400>  920
uguggaugga gacguaggca gg                                                22


<210>  921
<211>  22
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  22 mer antisense strand

<400>  921
ugauggugga uggagacgua gg                                                22


<210>  922
<211>  22
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  22 mer antisense strand

<400>  922
ugggauggug gauggagacg gg                                                22


<210>  923
<211>  22
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  22 mer antisense strand

<400>  923
uggucauggg gaugguggau gg                                                22


<210>  924
<211>  22
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  22 mer antisense strand

<400>  924
uccgugggaa caucagucgg gg                                                22


<210>  925
<211>  22
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  22 mer antisense strand

<400>  925
uuuucauuag cauccguggg gg                                                22


<210>  926
<211>  22
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  22 mer antisense strand

<400>  926
uccaguuuca uuagcauccg gg                                                22


<210>  927
<211>  22
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  22 mer antisense strand

<400>  927
ucaccaguuu cauuagcauc gg                                                22


<210>  928
<211>  22
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  22 mer antisense strand

<400>  928
uggcucacca guuucauuag gg                                                22


<210>  929
<211>  22
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  22 mer antisense strand

<400>  929
ugcucugagu ggacgcugcu gg                                                22


<210>  930
<211>  22
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  22 mer antisense strand

<400>  930
uuugcucuga guggacgcug gg                                                22


<210>  931
<211>  22
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  22 mer antisense strand

<400>  931
ucuugcucug aguggacgcu gg                                                22


<210>  932
<211>  22
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  22 mer antisense strand

<400>  932
ugacgcagug caaacacuug gg                                                22


<210>  933
<211>  22
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  22 mer antisense strand

<400>  933
ucagacgcag ugcaaacacu gg                                                22


<210>  934
<211>  22
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  22 mer antisense strand

<400>  934
uuuuuguccu gcagacgcag gg                                                22


<210>  935
<211>  22
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  22 mer antisense strand

<400>  935
ugugggagcu uuuuguccug gg                                                22


<210>  936
<211>  22
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  22 mer antisense strand

<400>  936
ugcacauccc agaucucaga gg                                                22


<210>  937
<211>  22
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  22 mer antisense strand

<400>  937
uuucgugcac aucccagauc gg                                                22


<210>  938
<211>  22
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  22 mer antisense strand

<400>  938
uauucgugca caucccagau gg                                                22


<210>  939
<211>  22
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  22 mer antisense strand

<400>  939
ucauucgugc acaucccaga gg                                                22


<210>  940
<211>  22
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  22 mer antisense strand

<400>  940
uguuccacuu cuaggaggca gg                                                22


<210>  941
<211>  22
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  22 mer antisense strand

<400>  941
ucucagucug uuccacuucu gg                                                22


<210>  942
<211>  22
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  22 mer antisense strand

<400>  942
uaauguuugc ccuucucagu gg                                                22


<210>  943
<211>  22
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  22 mer antisense strand

<400>  943
ugacucucuu uuaaugccac gg                                                22


<210>  944
<211>  22
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  22 mer antisense strand

<400>  944
uugacucucu uuuaaugcca gg                                                22


<210>  945
<211>  36
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  Modified sense strand


<220>
<221>  misc_feature
<222>  (1)..(2)
<223>  linked via phosphorothioate

<220>  
<221>  modified_base
<222>  (1)..(1)
<223>  2'-O-methyl modified

<220>  
<221>  modified_base
<222>  (2)..(2)
<223>  2'-O-methyl modified

<220>  
<221>  modified_base
<222>  (3)..(3)
<223>  2'-O-methyl modified

<220>  
<221>  modified_base
<222>  (4)..(4)
<223>  2'-O-methyl modified

<220>  
<221>  modified_base
<222>  (5)..(5)
<223>  2'-O-methyl modified

<220>  
<221>  modified_base
<222>  (6)..(6)
<223>  2'-O-methyl modified

<220>  
<221>  modified_base
<222>  (7)..(7)
<223>  2'-O-methyl modified

<220>  
<221>  modified_base
<222>  (8)..(8)
<223>  2'-fluoro modified

<220>  
<221>  modified_base
<222>  (9)..(9)
<223>  2'-fluoro modified

<220>  
<221>  modified_base
<222>  (10)..(10)
<223>  2'-fluoro modified

<220>  
<221>  modified_base
<222>  (11)..(11)
<223>  2'-fluoro modified

<220>  
<221>  modified_base
<222>  (12)..(12)
<223>  2'-O-methyl modified

<220>  
<221>  modified_base
<222>  (13)..(13)
<223>  2'-O-methyl modified

<220>  
<221>  modified_base
<222>  (14)..(14)
<223>  2'-O-methyl modified

<220>  
<221>  modified_base
<222>  (15)..(15)
<223>  2'-O-methyl modified

<220>  
<221>  modified_base
<222>  (16)..(16)
<223>  2'-O-methyl modified

<220>  
<221>  modified_base
<222>  (17)..(17)
<223>  2'-O-methyl modified

<220>  
<221>  modified_base
<222>  (18)..(18)
<223>  2'-O-methyl modified

<220>  
<221>  modified_base
<222>  (19)..(19)
<223>  2'-O-methyl modified

<220>  
<221>  modified_base
<222>  (20)..(20)
<223>  2'-O-methyl modified

<220>  
<221>  modified_base
<222>  (21)..(21)
<223>  2'-O-methyl modified

<220>  
<221>  modified_base
<222>  (22)..(22)
<223>  2'-O-methyl modified

<220>  
<221>  modified_base
<222>  (23)..(23)
<223>  2'-O-methyl modified

<220>  
<221>  modified_base
<222>  (24)..(24)
<223>  2'-O-methyl modified

<220>  
<221>  modified_base
<222>  (25)..(25)
<223>  2'-O-methyl modified

<220>  
<221>  modified_base
<222>  (26)..(26)
<223>  2'-O-methyl modified

<220>  
<221>  modified_base
<222>  (27)..(27)
<223>  2'-O-methyl modified

<220>  
<221>  modified_base
<222>  (28)..(28)
<223>  GalNAc-conjugated
<220>  
<221>  modified_base
<222>  (29)..(29)
<223>  GalNAc-conjugated
<220>  
<221>  modified_base
<222>  (30)..(30)
<223>  GalNAc-conjugated
<220>  
<221>  modified_base
<222>  (31)..(31)
<223>  2'-O-methyl modified

<220>  
<221>  modified_base
<222>  (32)..(32)
<223>  2'-O-methyl modified

<220>  
<221>  modified_base
<222>  (33)..(33)
<223>  2'-O-methyl modified

<220>  
<221>  modified_base
<222>  (34)..(34)
<223>  2'-O-methyl modified

<220>  
<221>  modified_base
<222>  (35)..(35)
<223>  2'-O-methyl modified

<220>  
<221>  modified_base
<222>  (36)..(36)
<223>  2'-O-methyl modified

<400>  945
guguccuguc agaagaacaa gcagccgaaa ggcugc                                 36


<210>  946
<211>  36
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  Modified sense strand


<220>
<221>  misc_feature
<222>  (1)..(2)
<223>  linked via phosphorothioate

<220>  
<221>  modified_base
<222>  (1)..(1)
<223>  2'-O-methyl modified

<220>  
<221>  modified_base
<222>  (2)..(2)
<223>  2'-O-methyl modified

<220>  
<221>  modified_base
<222>  (3)..(3)
<223>  2'-O-methyl modified

<220>  
<221>  modified_base
<222>  (4)..(4)
<223>  2'-O-methyl modified

<220>  
<221>  modified_base
<222>  (5)..(5)
<223>  2'-O-methyl modified

<220>  
<221>  modified_base
<222>  (6)..(6)
<223>  2'-O-methyl modified

<220>  
<221>  modified_base
<222>  (7)..(7)
<223>  2'-O-methyl modified

<220>  
<221>  modified_base
<222>  (8)..(8)
<223>  2'-fluoro modified

<220>  
<221>  modified_base
<222>  (9)..(9)
<223>  2'-fluoro modified

<220>  
<221>  modified_base
<222>  (10)..(10)
<223>  2'-fluoro modified

<220>  
<221>  modified_base
<222>  (11)..(11)
<223>  2'-fluoro modified

<220>  
<221>  modified_base
<222>  (12)..(12)
<223>  2'-O-methyl modified

<220>  
<221>  modified_base
<222>  (13)..(13)
<223>  2'-O-methyl modified

<220>  
<221>  modified_base
<222>  (14)..(14)
<223>  2'-O-methyl modified

<220>  
<221>  modified_base
<222>  (15)..(15)
<223>  2'-O-methyl modified

<220>  
<221>  modified_base
<222>  (16)..(16)
<223>  2'-O-methyl modified

<220>  
<221>  modified_base
<222>  (17)..(17)
<223>  2'-O-methyl modified

<220>  
<221>  modified_base
<222>  (18)..(18)
<223>  2'-O-methyl modified

<220>  
<221>  modified_base
<222>  (19)..(19)
<223>  2'-O-methyl modified

<220>  
<221>  modified_base
<222>  (20)..(20)
<223>  2'-O-methyl modified

<220>  
<221>  modified_base
<222>  (21)..(21)
<223>  2'-O-methyl modified

<220>  
<221>  modified_base
<222>  (22)..(22)
<223>  2'-O-methyl modified

<220>  
<221>  modified_base
<222>  (23)..(23)
<223>  2'-O-methyl modified

<220>  
<221>  modified_base
<222>  (24)..(24)
<223>  2'-O-methyl modified

<220>  
<221>  modified_base
<222>  (25)..(25)
<223>  2'-O-methyl modified

<220>  
<221>  modified_base
<222>  (26)..(26)
<223>  2'-O-methyl modified

<220>  
<221>  modified_base
<222>  (27)..(27)
<223>  2'-O-methyl modified

<220>  
<221>  modified_base
<222>  (28)..(28)
<223>  GalNAc-conjugated
<220>  
<221>  modified_base
<222>  (29)..(29)
<223>  GalNAc-conjugated
<220>  
<221>  modified_base
<222>  (30)..(30)
<223>  GalNAc-conjugated
<220>  
<221>  modified_base
<222>  (31)..(31)
<223>  2'-O-methyl modified

<220>  
<221>  modified_base
<222>  (32)..(32)
<223>  2'-O-methyl modified

<220>  
<221>  modified_base
<222>  (33)..(33)
<223>  2'-O-methyl modified

<220>  
<221>  modified_base
<222>  (34)..(34)
<223>  2'-O-methyl modified

<220>  
<221>  modified_base
<222>  (35)..(35)
<223>  2'-O-methyl modified

<220>  
<221>  modified_base
<222>  (36)..(36)
<223>  2'-O-methyl modified

<400>  946
guccugucag aagaacagaa gcagccgaaa ggcugc                                 36


<210>  947
<211>  36
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  Modified sense strand


<220>
<221>  misc_feature
<222>  (1)..(2)
<223>  linked via phosphorothioate

<220>  
<221>  modified_base
<222>  (1)..(1)
<223>  2'-O-methyl modified

<220>  
<221>  modified_base
<222>  (2)..(2)
<223>  2'-O-methyl modified

<220>  
<221>  modified_base
<222>  (3)..(3)
<223>  2'-O-methyl modified

<220>  
<221>  modified_base
<222>  (4)..(4)
<223>  2'-O-methyl modified

<220>  
<221>  modified_base
<222>  (5)..(5)
<223>  2'-O-methyl modified

<220>  
<221>  modified_base
<222>  (6)..(6)
<223>  2'-O-methyl modified

<220>  
<221>  modified_base
<222>  (7)..(7)
<223>  2'-O-methyl modified

<220>  
<221>  modified_base
<222>  (8)..(8)
<223>  2'-fluoro modified

<220>  
<221>  modified_base
<222>  (9)..(9)
<223>  2'-fluoro modified

<220>  
<221>  modified_base
<222>  (10)..(10)
<223>  2'-fluoro modified

<220>  
<221>  modified_base
<222>  (11)..(11)
<223>  2'-fluoro modified

<220>  
<221>  modified_base
<222>  (12)..(12)
<223>  2'-O-methyl modified

<220>  
<221>  modified_base
<222>  (13)..(13)
<223>  2'-O-methyl modified

<220>  
<221>  modified_base
<222>  (14)..(14)
<223>  2'-O-methyl modified

<220>  
<221>  modified_base
<222>  (15)..(15)
<223>  2'-O-methyl modified

<220>  
<221>  modified_base
<222>  (16)..(16)
<223>  2'-O-methyl modified

<220>  
<221>  modified_base
<222>  (17)..(17)
<223>  2'-O-methyl modified

<220>  
<221>  modified_base
<222>  (18)..(18)
<223>  2'-O-methyl modified

<220>  
<221>  modified_base
<222>  (19)..(19)
<223>  2'-O-methyl modified

<220>  
<221>  modified_base
<222>  (20)..(20)
<223>  2'-O-methyl modified

<220>  
<221>  modified_base
<222>  (21)..(21)
<223>  2'-O-methyl modified

<220>  
<221>  modified_base
<222>  (22)..(22)
<223>  2'-O-methyl modified

<220>  
<221>  modified_base
<222>  (23)..(23)
<223>  2'-O-methyl modified

<220>  
<221>  modified_base
<222>  (24)..(24)
<223>  2'-O-methyl modified

<220>  
<221>  modified_base
<222>  (25)..(25)
<223>  2'-O-methyl modified

<220>  
<221>  modified_base
<222>  (26)..(26)
<223>  2'-O-methyl modified

<220>  
<221>  modified_base
<222>  (27)..(27)
<223>  2'-O-methyl modified

<220>  
<221>  modified_base
<222>  (28)..(28)
<223>  GalNAc-conjugated
<220>  
<221>  modified_base
<222>  (29)..(29)
<223>  GalNAc-conjugated
<220>  
<221>  modified_base
<222>  (30)..(30)
<223>  GalNAc-conjugated
<220>  
<221>  modified_base
<222>  (31)..(31)
<223>  2'-O-methyl modified

<220>  
<221>  modified_base
<222>  (32)..(32)
<223>  2'-O-methyl modified

<220>  
<221>  modified_base
<222>  (33)..(33)
<223>  2'-O-methyl modified

<220>  
<221>  modified_base
<222>  (34)..(34)
<223>  2'-O-methyl modified

<220>  
<221>  modified_base
<222>  (35)..(35)
<223>  2'-O-methyl modified

<220>  
<221>  modified_base
<222>  (36)..(36)
<223>  2'-O-methyl modified

<400>  947
ccugucagaa gaacagauca gcagccgaaa ggcugc                                 36


<210>  948
<211>  36
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  Modified sense strand


<220>
<221>  misc_feature
<222>  (1)..(2)
<223>  linked via phosphorothioate

<220>  
<221>  modified_base
<222>  (1)..(1)
<223>  2'-O-methyl modified

<220>  
<221>  modified_base
<222>  (2)..(2)
<223>  2'-O-methyl modified

<220>  
<221>  modified_base
<222>  (3)..(3)
<223>  2'-O-methyl modified

<220>  
<221>  modified_base
<222>  (4)..(4)
<223>  2'-O-methyl modified

<220>  
<221>  modified_base
<222>  (5)..(5)
<223>  2'-O-methyl modified

<220>  
<221>  modified_base
<222>  (6)..(6)
<223>  2'-O-methyl modified

<220>  
<221>  modified_base
<222>  (7)..(7)
<223>  2'-O-methyl modified

<220>  
<221>  modified_base
<222>  (8)..(8)
<223>  2'-fluoro modified

<220>  
<221>  modified_base
<222>  (9)..(9)
<223>  2'-fluoro modified

<220>  
<221>  modified_base
<222>  (10)..(10)
<223>  2'-fluoro modified

<220>  
<221>  modified_base
<222>  (11)..(11)
<223>  2'-fluoro modified

<220>  
<221>  modified_base
<222>  (12)..(12)
<223>  2'-O-methyl modified

<220>  
<221>  modified_base
<222>  (13)..(13)
<223>  2'-O-methyl modified

<220>  
<221>  modified_base
<222>  (14)..(14)
<223>  2'-O-methyl modified

<220>  
<221>  modified_base
<222>  (15)..(15)
<223>  2'-O-methyl modified

<220>  
<221>  modified_base
<222>  (16)..(16)
<223>  2'-O-methyl modified

<220>  
<221>  modified_base
<222>  (17)..(17)
<223>  2'-O-methyl modified

<220>  
<221>  modified_base
<222>  (18)..(18)
<223>  2'-O-methyl modified

<220>  
<221>  modified_base
<222>  (19)..(19)
<223>  2'-O-methyl modified

<220>  
<221>  modified_base
<222>  (20)..(20)
<223>  2'-O-methyl modified

<220>  
<221>  modified_base
<222>  (21)..(21)
<223>  2'-O-methyl modified

<220>  
<221>  modified_base
<222>  (22)..(22)
<223>  2'-O-methyl modified

<220>  
<221>  modified_base
<222>  (23)..(23)
<223>  2'-O-methyl modified

<220>  
<221>  modified_base
<222>  (24)..(24)
<223>  2'-O-methyl modified

<220>  
<221>  modified_base
<222>  (25)..(25)
<223>  2'-O-methyl modified

<220>  
<221>  modified_base
<222>  (26)..(26)
<223>  2'-O-methyl modified

<220>  
<221>  modified_base
<222>  (27)..(27)
<223>  2'-O-methyl modified

<220>  
<221>  modified_base
<222>  (28)..(28)
<223>  GalNAc-conjugated
<220>  
<221>  modified_base
<222>  (29)..(29)
<223>  GalNAc-conjugated
<220>  
<221>  modified_base
<222>  (30)..(30)
<223>  GalNAc-conjugated
<220>  
<221>  modified_base
<222>  (31)..(31)
<223>  2'-O-methyl modified

<220>  
<221>  modified_base
<222>  (32)..(32)
<223>  2'-O-methyl modified

<220>  
<221>  modified_base
<222>  (33)..(33)
<223>  2'-O-methyl modified

<220>  
<221>  modified_base
<222>  (34)..(34)
<223>  2'-O-methyl modified

<220>  
<221>  modified_base
<222>  (35)..(35)
<223>  2'-O-methyl modified

<220>  
<221>  modified_base
<222>  (36)..(36)
<223>  2'-O-methyl modified

<400>  948
cugucagaag aacagaucca gcagccgaaa ggcugc                                 36


<210>  949
<211>  36
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  Modified sense strand


<220>
<221>  misc_feature
<222>  (1)..(2)
<223>  linked via phosphorothioate

<220>  
<221>  modified_base
<222>  (1)..(1)
<223>  2'-O-methyl modified

<220>  
<221>  modified_base
<222>  (2)..(2)
<223>  2'-O-methyl modified

<220>  
<221>  modified_base
<222>  (3)..(3)
<223>  2'-O-methyl modified

<220>  
<221>  modified_base
<222>  (4)..(4)
<223>  2'-O-methyl modified

<220>  
<221>  modified_base
<222>  (5)..(5)
<223>  2'-O-methyl modified

<220>  
<221>  modified_base
<222>  (6)..(6)
<223>  2'-O-methyl modified

<220>  
<221>  modified_base
<222>  (7)..(7)
<223>  2'-O-methyl modified

<220>  
<221>  modified_base
<222>  (8)..(8)
<223>  2'-fluoro modified

<220>  
<221>  modified_base
<222>  (9)..(9)
<223>  2'-fluoro modified

<220>  
<221>  modified_base
<222>  (10)..(10)
<223>  2'-fluoro modified

<220>  
<221>  modified_base
<222>  (11)..(11)
<223>  2'-fluoro modified

<220>  
<221>  modified_base
<222>  (12)..(12)
<223>  2'-O-methyl modified

<220>  
<221>  modified_base
<222>  (13)..(13)
<223>  2'-O-methyl modified

<220>  
<221>  modified_base
<222>  (14)..(14)
<223>  2'-O-methyl modified

<220>  
<221>  modified_base
<222>  (15)..(15)
<223>  2'-O-methyl modified

<220>  
<221>  modified_base
<222>  (16)..(16)
<223>  2'-O-methyl modified

<220>  
<221>  modified_base
<222>  (17)..(17)
<223>  2'-O-methyl modified

<220>  
<221>  modified_base
<222>  (18)..(18)
<223>  2'-O-methyl modified

<220>  
<221>  modified_base
<222>  (19)..(19)
<223>  2'-O-methyl modified

<220>  
<221>  modified_base
<222>  (20)..(20)
<223>  2'-O-methyl modified

<220>  
<221>  modified_base
<222>  (21)..(21)
<223>  2'-O-methyl modified

<220>  
<221>  modified_base
<222>  (22)..(22)
<223>  2'-O-methyl modified

<220>  
<221>  modified_base
<222>  (23)..(23)
<223>  2'-O-methyl modified

<220>  
<221>  modified_base
<222>  (24)..(24)
<223>  2'-O-methyl modified

<220>  
<221>  modified_base
<222>  (25)..(25)
<223>  2'-O-methyl modified

<220>  
<221>  modified_base
<222>  (26)..(26)
<223>  2'-O-methyl modified

<220>  
<221>  modified_base
<222>  (27)..(27)
<223>  2'-O-methyl modified

<220>  
<221>  modified_base
<222>  (28)..(28)
<223>  GalNAc-conjugated
<220>  
<221>  modified_base
<222>  (29)..(29)
<223>  GalNAc-conjugated
<220>  
<221>  modified_base
<222>  (30)..(30)
<223>  GalNAc-conjugated
<220>  
<221>  modified_base
<222>  (31)..(31)
<223>  2'-O-methyl modified

<220>  
<221>  modified_base
<222>  (32)..(32)
<223>  2'-O-methyl modified

<220>  
<221>  modified_base
<222>  (33)..(33)
<223>  2'-O-methyl modified

<220>  
<221>  modified_base
<222>  (34)..(34)
<223>  2'-O-methyl modified

<220>  
<221>  modified_base
<222>  (35)..(35)
<223>  2'-O-methyl modified

<220>  
<221>  modified_base
<222>  (36)..(36)
<223>  2'-O-methyl modified

<400>  949
ugucagaaga acagauccga gcagccgaaa ggcugc                                 36


<210>  950
<211>  36
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  Modified sense strand


<220>
<221>  misc_feature
<222>  (1)..(2)
<223>  linked via phosphorothioate

<220>  
<221>  modified_base
<222>  (1)..(1)
<223>  2'-O-methyl modified

<220>  
<221>  modified_base
<222>  (2)..(2)
<223>  2'-O-methyl modified

<220>  
<221>  modified_base
<222>  (3)..(3)
<223>  2'-O-methyl modified

<220>  
<221>  modified_base
<222>  (4)..(4)
<223>  2'-O-methyl modified

<220>  
<221>  modified_base
<222>  (5)..(5)
<223>  2'-O-methyl modified

<220>  
<221>  modified_base
<222>  (6)..(6)
<223>  2'-O-methyl modified

<220>  
<221>  modified_base
<222>  (7)..(7)
<223>  2'-O-methyl modified

<220>  
<221>  modified_base
<222>  (8)..(8)
<223>  2'-fluoro modified

<220>  
<221>  modified_base
<222>  (9)..(9)
<223>  2'-fluoro modified

<220>  
<221>  modified_base
<222>  (10)..(10)
<223>  2'-fluoro modified

<220>  
<221>  modified_base
<222>  (11)..(11)
<223>  2'-fluoro modified

<220>  
<221>  modified_base
<222>  (12)..(12)
<223>  2'-O-methyl modified

<220>  
<221>  modified_base
<222>  (13)..(13)
<223>  2'-O-methyl modified

<220>  
<221>  modified_base
<222>  (14)..(14)
<223>  2'-O-methyl modified

<220>  
<221>  modified_base
<222>  (15)..(15)
<223>  2'-O-methyl modified

<220>  
<221>  modified_base
<222>  (16)..(16)
<223>  2'-O-methyl modified

<220>  
<221>  modified_base
<222>  (17)..(17)
<223>  2'-O-methyl modified

<220>  
<221>  modified_base
<222>  (18)..(18)
<223>  2'-O-methyl modified

<220>  
<221>  modified_base
<222>  (19)..(19)
<223>  2'-O-methyl modified

<220>  
<221>  modified_base
<222>  (20)..(20)
<223>  2'-O-methyl modified

<220>  
<221>  modified_base
<222>  (21)..(21)
<223>  2'-O-methyl modified

<220>  
<221>  modified_base
<222>  (22)..(22)
<223>  2'-O-methyl modified

<220>  
<221>  modified_base
<222>  (23)..(23)
<223>  2'-O-methyl modified

<220>  
<221>  modified_base
<222>  (24)..(24)
<223>  2'-O-methyl modified

<220>  
<221>  modified_base
<222>  (25)..(25)
<223>  2'-O-methyl modified

<220>  
<221>  modified_base
<222>  (26)..(26)
<223>  2'-O-methyl modified

<220>  
<221>  modified_base
<222>  (27)..(27)
<223>  2'-O-methyl modified

<220>  
<221>  modified_base
<222>  (28)..(28)
<223>  GalNAc-conjugated
<220>  
<221>  modified_base
<222>  (29)..(29)
<223>  GalNAc-conjugated
<220>  
<221>  modified_base
<222>  (30)..(30)
<223>  GalNAc-conjugated
<220>  
<221>  modified_base
<222>  (31)..(31)
<223>  2'-O-methyl modified

<220>  
<221>  modified_base
<222>  (32)..(32)
<223>  2'-O-methyl modified

<220>  
<221>  modified_base
<222>  (33)..(33)
<223>  2'-O-methyl modified

<220>  
<221>  modified_base
<222>  (34)..(34)
<223>  2'-O-methyl modified

<220>  
<221>  modified_base
<222>  (35)..(35)
<223>  2'-O-methyl modified

<220>  
<221>  modified_base
<222>  (36)..(36)
<223>  2'-O-methyl modified

<400>  950
gaaacugaag cggcaagaga gcagccgaaa ggcugc                                 36


<210>  951
<211>  36
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  Modified sense strand


<220>
<221>  misc_feature
<222>  (1)..(2)
<223>  linked via phosphorothioate

<220>  
<221>  modified_base
<222>  (1)..(1)
<223>  2'-O-methyl modified

<220>  
<221>  modified_base
<222>  (2)..(2)
<223>  2'-O-methyl modified

<220>  
<221>  modified_base
<222>  (3)..(3)
<223>  2'-O-methyl modified

<220>  
<221>  modified_base
<222>  (4)..(4)
<223>  2'-O-methyl modified

<220>  
<221>  modified_base
<222>  (5)..(5)
<223>  2'-O-methyl modified

<220>  
<221>  modified_base
<222>  (6)..(6)
<223>  2'-O-methyl modified

<220>  
<221>  modified_base
<222>  (7)..(7)
<223>  2'-O-methyl modified

<220>  
<221>  modified_base
<222>  (8)..(8)
<223>  2'-fluoro modified

<220>  
<221>  modified_base
<222>  (9)..(9)
<223>  2'-fluoro modified

<220>  
<221>  modified_base
<222>  (10)..(10)
<223>  2'-fluoro modified

<220>  
<221>  modified_base
<222>  (11)..(11)
<223>  2'-fluoro modified

<220>  
<221>  modified_base
<222>  (12)..(12)
<223>  2'-O-methyl modified

<220>  
<221>  modified_base
<222>  (13)..(13)
<223>  2'-O-methyl modified

<220>  
<221>  modified_base
<222>  (14)..(14)
<223>  2'-O-methyl modified

<220>  
<221>  modified_base
<222>  (15)..(15)
<223>  2'-O-methyl modified

<220>  
<221>  modified_base
<222>  (16)..(16)
<223>  2'-O-methyl modified

<220>  
<221>  modified_base
<222>  (17)..(17)
<223>  2'-O-methyl modified

<220>  
<221>  modified_base
<222>  (18)..(18)
<223>  2'-O-methyl modified

<220>  
<221>  modified_base
<222>  (19)..(19)
<223>  2'-O-methyl modified

<220>  
<221>  modified_base
<222>  (20)..(20)
<223>  2'-O-methyl modified

<220>  
<221>  modified_base
<222>  (21)..(21)
<223>  2'-O-methyl modified

<220>  
<221>  modified_base
<222>  (22)..(22)
<223>  2'-O-methyl modified

<220>  
<221>  modified_base
<222>  (23)..(23)
<223>  2'-O-methyl modified

<220>  
<221>  modified_base
<222>  (24)..(24)
<223>  2'-O-methyl modified

<220>  
<221>  modified_base
<222>  (25)..(25)
<223>  2'-O-methyl modified

<220>  
<221>  modified_base
<222>  (26)..(26)
<223>  2'-O-methyl modified

<220>  
<221>  modified_base
<222>  (27)..(27)
<223>  2'-O-methyl modified

<220>  
<221>  modified_base
<222>  (28)..(28)
<223>  GalNAc-conjugated
<220>  
<221>  modified_base
<222>  (29)..(29)
<223>  GalNAc-conjugated
<220>  
<221>  modified_base
<222>  (30)..(30)
<223>  GalNAc-conjugated
<220>  
<221>  modified_base
<222>  (31)..(31)
<223>  2'-O-methyl modified

<220>  
<221>  modified_base
<222>  (32)..(32)
<223>  2'-O-methyl modified

<220>  
<221>  modified_base
<222>  (33)..(33)
<223>  2'-O-methyl modified

<220>  
<221>  modified_base
<222>  (34)..(34)
<223>  2'-O-methyl modified

<220>  
<221>  modified_base
<222>  (35)..(35)
<223>  2'-O-methyl modified

<220>  
<221>  modified_base
<222>  (36)..(36)
<223>  2'-O-methyl modified

<400>  951
gugaugcuuc uggagacaua gcagccgaaa ggcugc                                 36


<210>  952
<211>  36
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  Modified sense strand


<220>
<221>  misc_feature
<222>  (1)..(2)
<223>  linked via phosphorothioate

<220>  
<221>  modified_base
<222>  (1)..(1)
<223>  2'-O-methyl modified

<220>  
<221>  modified_base
<222>  (2)..(2)
<223>  2'-O-methyl modified

<220>  
<221>  modified_base
<222>  (3)..(3)
<223>  2'-O-methyl modified

<220>  
<221>  modified_base
<222>  (4)..(4)
<223>  2'-O-methyl modified

<220>  
<221>  modified_base
<222>  (5)..(5)
<223>  2'-O-methyl modified

<220>  
<221>  modified_base
<222>  (6)..(6)
<223>  2'-O-methyl modified

<220>  
<221>  modified_base
<222>  (7)..(7)
<223>  2'-O-methyl modified

<220>  
<221>  modified_base
<222>  (8)..(8)
<223>  2'-fluoro modified

<220>  
<221>  modified_base
<222>  (9)..(9)
<223>  2'-fluoro modified

<220>  
<221>  modified_base
<222>  (10)..(10)
<223>  2'-fluoro modified

<220>  
<221>  modified_base
<222>  (11)..(11)
<223>  2'-fluoro modified

<220>  
<221>  modified_base
<222>  (12)..(12)
<223>  2'-O-methyl modified

<220>  
<221>  modified_base
<222>  (13)..(13)
<223>  2'-O-methyl modified

<220>  
<221>  modified_base
<222>  (14)..(14)
<223>  2'-O-methyl modified

<220>  
<221>  modified_base
<222>  (15)..(15)
<223>  2'-O-methyl modified

<220>  
<221>  modified_base
<222>  (16)..(16)
<223>  2'-O-methyl modified

<220>  
<221>  modified_base
<222>  (17)..(17)
<223>  2'-O-methyl modified

<220>  
<221>  modified_base
<222>  (18)..(18)
<223>  2'-O-methyl modified

<220>  
<221>  modified_base
<222>  (19)..(19)
<223>  2'-O-methyl modified

<220>  
<221>  modified_base
<222>  (20)..(20)
<223>  2'-O-methyl modified

<220>  
<221>  modified_base
<222>  (21)..(21)
<223>  2'-O-methyl modified

<220>  
<221>  modified_base
<222>  (22)..(22)
<223>  2'-O-methyl modified

<220>  
<221>  modified_base
<222>  (23)..(23)
<223>  2'-O-methyl modified

<220>  
<221>  modified_base
<222>  (24)..(24)
<223>  2'-O-methyl modified

<220>  
<221>  modified_base
<222>  (25)..(25)
<223>  2'-O-methyl modified

<220>  
<221>  modified_base
<222>  (26)..(26)
<223>  2'-O-methyl modified

<220>  
<221>  modified_base
<222>  (27)..(27)
<223>  2'-O-methyl modified

<220>  
<221>  modified_base
<222>  (28)..(28)
<223>  GalNAc-conjugated
<220>  
<221>  modified_base
<222>  (29)..(29)
<223>  GalNAc-conjugated
<220>  
<221>  modified_base
<222>  (30)..(30)
<223>  GalNAc-conjugated
<220>  
<221>  modified_base
<222>  (31)..(31)
<223>  2'-O-methyl modified

<220>  
<221>  modified_base
<222>  (32)..(32)
<223>  2'-O-methyl modified

<220>  
<221>  modified_base
<222>  (33)..(33)
<223>  2'-O-methyl modified

<220>  
<221>  modified_base
<222>  (34)..(34)
<223>  2'-O-methyl modified

<220>  
<221>  modified_base
<222>  (35)..(35)
<223>  2'-O-methyl modified

<220>  
<221>  modified_base
<222>  (36)..(36)
<223>  2'-O-methyl modified

<400>  952
ggagugagag uaucaccuua gcagccgaaa ggcugc                                 36


<210>  953
<211>  36
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  Modified sense strand


<220>
<221>  misc_feature
<222>  (1)..(2)
<223>  linked via phosphorothioate

<220>  
<221>  modified_base
<222>  (1)..(1)
<223>  2'-O-methyl modified

<220>  
<221>  modified_base
<222>  (2)..(2)
<223>  2'-O-methyl modified

<220>  
<221>  modified_base
<222>  (3)..(3)
<223>  2'-O-methyl modified

<220>  
<221>  modified_base
<222>  (4)..(4)
<223>  2'-O-methyl modified

<220>  
<221>  modified_base
<222>  (5)..(5)
<223>  2'-O-methyl modified

<220>  
<221>  modified_base
<222>  (6)..(6)
<223>  2'-O-methyl modified

<220>  
<221>  modified_base
<222>  (7)..(7)
<223>  2'-O-methyl modified

<220>  
<221>  modified_base
<222>  (8)..(8)
<223>  2'-fluoro modified

<220>  
<221>  modified_base
<222>  (9)..(9)
<223>  2'-fluoro modified

<220>  
<221>  modified_base
<222>  (10)..(10)
<223>  2'-fluoro modified

<220>  
<221>  modified_base
<222>  (11)..(11)
<223>  2'-fluoro modified

<220>  
<221>  modified_base
<222>  (12)..(12)
<223>  2'-O-methyl modified

<220>  
<221>  modified_base
<222>  (13)..(13)
<223>  2'-O-methyl modified

<220>  
<221>  modified_base
<222>  (14)..(14)
<223>  2'-O-methyl modified

<220>  
<221>  modified_base
<222>  (15)..(15)
<223>  2'-O-methyl modified

<220>  
<221>  modified_base
<222>  (16)..(16)
<223>  2'-O-methyl modified

<220>  
<221>  modified_base
<222>  (17)..(17)
<223>  2'-O-methyl modified

<220>  
<221>  modified_base
<222>  (18)..(18)
<223>  2'-O-methyl modified

<220>  
<221>  modified_base
<222>  (19)..(19)
<223>  2'-O-methyl modified

<220>  
<221>  modified_base
<222>  (20)..(20)
<223>  2'-O-methyl modified

<220>  
<221>  modified_base
<222>  (21)..(21)
<223>  2'-O-methyl modified

<220>  
<221>  modified_base
<222>  (22)..(22)
<223>  2'-O-methyl modified

<220>  
<221>  modified_base
<222>  (23)..(23)
<223>  2'-O-methyl modified

<220>  
<221>  modified_base
<222>  (24)..(24)
<223>  2'-O-methyl modified

<220>  
<221>  modified_base
<222>  (25)..(25)
<223>  2'-O-methyl modified

<220>  
<221>  modified_base
<222>  (26)..(26)
<223>  2'-O-methyl modified

<220>  
<221>  modified_base
<222>  (27)..(27)
<223>  2'-O-methyl modified

<220>  
<221>  modified_base
<222>  (28)..(28)
<223>  GalNAc-conjugated
<220>  
<221>  modified_base
<222>  (29)..(29)
<223>  GalNAc-conjugated
<220>  
<221>  modified_base
<222>  (30)..(30)
<223>  GalNAc-conjugated
<220>  
<221>  modified_base
<222>  (31)..(31)
<223>  2'-O-methyl modified

<220>  
<221>  modified_base
<222>  (32)..(32)
<223>  2'-O-methyl modified

<220>  
<221>  modified_base
<222>  (33)..(33)
<223>  2'-O-methyl modified

<220>  
<221>  modified_base
<222>  (34)..(34)
<223>  2'-O-methyl modified

<220>  
<221>  modified_base
<222>  (35)..(35)
<223>  2'-O-methyl modified

<220>  
<221>  modified_base
<222>  (36)..(36)
<223>  2'-O-methyl modified

<400>  953
agaguaucac cuuccucaaa gcagccgaaa ggcugc                                 36


<210>  954
<211>  36
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  Modified sense strand


<220>
<221>  misc_feature
<222>  (1)..(2)
<223>  linked via phosphorothioate

<220>  
<221>  modified_base
<222>  (1)..(1)
<223>  2'-O-methyl modified

<220>  
<221>  modified_base
<222>  (2)..(2)
<223>  2'-O-methyl modified

<220>  
<221>  modified_base
<222>  (3)..(3)
<223>  2'-O-methyl modified

<220>  
<221>  modified_base
<222>  (4)..(4)
<223>  2'-O-methyl modified

<220>  
<221>  modified_base
<222>  (5)..(5)
<223>  2'-O-methyl modified

<220>  
<221>  modified_base
<222>  (6)..(6)
<223>  2'-O-methyl modified

<220>  
<221>  modified_base
<222>  (7)..(7)
<223>  2'-O-methyl modified

<220>  
<221>  modified_base
<222>  (8)..(8)
<223>  2'-fluoro modified

<220>  
<221>  modified_base
<222>  (9)..(9)
<223>  2'-fluoro modified

<220>  
<221>  modified_base
<222>  (10)..(10)
<223>  2'-fluoro modified

<220>  
<221>  modified_base
<222>  (11)..(11)
<223>  2'-fluoro modified

<220>  
<221>  modified_base
<222>  (12)..(12)
<223>  2'-O-methyl modified

<220>  
<221>  modified_base
<222>  (13)..(13)
<223>  2'-O-methyl modified

<220>  
<221>  modified_base
<222>  (14)..(14)
<223>  2'-O-methyl modified

<220>  
<221>  modified_base
<222>  (15)..(15)
<223>  2'-O-methyl modified

<220>  
<221>  modified_base
<222>  (16)..(16)
<223>  2'-O-methyl modified

<220>  
<221>  modified_base
<222>  (17)..(17)
<223>  2'-O-methyl modified

<220>  
<221>  modified_base
<222>  (18)..(18)
<223>  2'-O-methyl modified

<220>  
<221>  modified_base
<222>  (19)..(19)
<223>  2'-O-methyl modified

<220>  
<221>  modified_base
<222>  (20)..(20)
<223>  2'-O-methyl modified

<220>  
<221>  modified_base
<222>  (21)..(21)
<223>  2'-O-methyl modified

<220>  
<221>  modified_base
<222>  (22)..(22)
<223>  2'-O-methyl modified

<220>  
<221>  modified_base
<222>  (23)..(23)
<223>  2'-O-methyl modified

<220>  
<221>  modified_base
<222>  (24)..(24)
<223>  2'-O-methyl modified

<220>  
<221>  modified_base
<222>  (25)..(25)
<223>  2'-O-methyl modified

<220>  
<221>  modified_base
<222>  (26)..(26)
<223>  2'-O-methyl modified

<220>  
<221>  modified_base
<222>  (27)..(27)
<223>  2'-O-methyl modified

<220>  
<221>  modified_base
<222>  (28)..(28)
<223>  GalNAc-conjugated
<220>  
<221>  modified_base
<222>  (29)..(29)
<223>  GalNAc-conjugated
<220>  
<221>  modified_base
<222>  (30)..(30)
<223>  GalNAc-conjugated
<220>  
<221>  modified_base
<222>  (31)..(31)
<223>  2'-O-methyl modified

<220>  
<221>  modified_base
<222>  (32)..(32)
<223>  2'-O-methyl modified

<220>  
<221>  modified_base
<222>  (33)..(33)
<223>  2'-O-methyl modified

<220>  
<221>  modified_base
<222>  (34)..(34)
<223>  2'-O-methyl modified

<220>  
<221>  modified_base
<222>  (35)..(35)
<223>  2'-O-methyl modified

<220>  
<221>  modified_base
<222>  (36)..(36)
<223>  2'-O-methyl modified

<400>  954
aucaccuucc ucaaggauua gcagccgaaa ggcugc                                 36


<210>  955
<211>  36
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  Modified sense strand


<220>
<221>  misc_feature
<222>  (1)..(2)
<223>  linked via phosphorothioate

<220>  
<221>  modified_base
<222>  (1)..(1)
<223>  2'-O-methyl modified

<220>  
<221>  modified_base
<222>  (2)..(2)
<223>  2'-O-methyl modified

<220>  
<221>  modified_base
<222>  (3)..(3)
<223>  2'-O-methyl modified

<220>  
<221>  modified_base
<222>  (4)..(4)
<223>  2'-O-methyl modified

<220>  
<221>  modified_base
<222>  (5)..(5)
<223>  2'-O-methyl modified

<220>  
<221>  modified_base
<222>  (6)..(6)
<223>  2'-O-methyl modified

<220>  
<221>  modified_base
<222>  (7)..(7)
<223>  2'-O-methyl modified

<220>  
<221>  modified_base
<222>  (8)..(8)
<223>  2'-fluoro modified

<220>  
<221>  modified_base
<222>  (9)..(9)
<223>  2'-fluoro modified

<220>  
<221>  modified_base
<222>  (10)..(10)
<223>  2'-fluoro modified

<220>  
<221>  modified_base
<222>  (11)..(11)
<223>  2'-fluoro modified

<220>  
<221>  modified_base
<222>  (12)..(12)
<223>  2'-O-methyl modified

<220>  
<221>  modified_base
<222>  (13)..(13)
<223>  2'-O-methyl modified

<220>  
<221>  modified_base
<222>  (14)..(14)
<223>  2'-O-methyl modified

<220>  
<221>  modified_base
<222>  (15)..(15)
<223>  2'-O-methyl modified

<220>  
<221>  modified_base
<222>  (16)..(16)
<223>  2'-O-methyl modified

<220>  
<221>  modified_base
<222>  (17)..(17)
<223>  2'-O-methyl modified

<220>  
<221>  modified_base
<222>  (18)..(18)
<223>  2'-O-methyl modified

<220>  
<221>  modified_base
<222>  (19)..(19)
<223>  2'-O-methyl modified

<220>  
<221>  modified_base
<222>  (20)..(20)
<223>  2'-O-methyl modified

<220>  
<221>  modified_base
<222>  (21)..(21)
<223>  2'-O-methyl modified

<220>  
<221>  modified_base
<222>  (22)..(22)
<223>  2'-O-methyl modified

<220>  
<221>  modified_base
<222>  (23)..(23)
<223>  2'-O-methyl modified

<220>  
<221>  modified_base
<222>  (24)..(24)
<223>  2'-O-methyl modified

<220>  
<221>  modified_base
<222>  (25)..(25)
<223>  2'-O-methyl modified

<220>  
<221>  modified_base
<222>  (26)..(26)
<223>  2'-O-methyl modified

<220>  
<221>  modified_base
<222>  (27)..(27)
<223>  2'-O-methyl modified

<220>  
<221>  modified_base
<222>  (28)..(28)
<223>  GalNAc-conjugated
<220>  
<221>  modified_base
<222>  (29)..(29)
<223>  GalNAc-conjugated
<220>  
<221>  modified_base
<222>  (30)..(30)
<223>  GalNAc-conjugated
<220>  
<221>  modified_base
<222>  (31)..(31)
<223>  2'-O-methyl modified

<220>  
<221>  modified_base
<222>  (32)..(32)
<223>  2'-O-methyl modified

<220>  
<221>  modified_base
<222>  (33)..(33)
<223>  2'-O-methyl modified

<220>  
<221>  modified_base
<222>  (34)..(34)
<223>  2'-O-methyl modified

<220>  
<221>  modified_base
<222>  (35)..(35)
<223>  2'-O-methyl modified

<220>  
<221>  modified_base
<222>  (36)..(36)
<223>  2'-O-methyl modified

<400>  955
ucaccuuccu caaggauuua gcagccgaaa ggcugc                                 36


<210>  956
<211>  36
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  Modified sense strand


<220>
<221>  misc_feature
<222>  (1)..(2)
<223>  linked via phosphorothioate

<220>  
<221>  modified_base
<222>  (1)..(1)
<223>  2'-O-methyl modified

<220>  
<221>  modified_base
<222>  (2)..(2)
<223>  2'-O-methyl modified

<220>  
<221>  modified_base
<222>  (3)..(3)
<223>  2'-O-methyl modified

<220>  
<221>  modified_base
<222>  (4)..(4)
<223>  2'-O-methyl modified

<220>  
<221>  modified_base
<222>  (5)..(5)
<223>  2'-O-methyl modified

<220>  
<221>  modified_base
<222>  (6)..(6)
<223>  2'-O-methyl modified

<220>  
<221>  modified_base
<222>  (7)..(7)
<223>  2'-O-methyl modified

<220>  
<221>  modified_base
<222>  (8)..(8)
<223>  2'-fluoro modified

<220>  
<221>  modified_base
<222>  (9)..(9)
<223>  2'-fluoro modified

<220>  
<221>  modified_base
<222>  (10)..(10)
<223>  2'-fluoro modified

<220>  
<221>  modified_base
<222>  (11)..(11)
<223>  2'-fluoro modified

<220>  
<221>  modified_base
<222>  (12)..(12)
<223>  2'-O-methyl modified

<220>  
<221>  modified_base
<222>  (13)..(13)
<223>  2'-O-methyl modified

<220>  
<221>  modified_base
<222>  (14)..(14)
<223>  2'-O-methyl modified

<220>  
<221>  modified_base
<222>  (15)..(15)
<223>  2'-O-methyl modified

<220>  
<221>  modified_base
<222>  (16)..(16)
<223>  2'-O-methyl modified

<220>  
<221>  modified_base
<222>  (17)..(17)
<223>  2'-O-methyl modified

<220>  
<221>  modified_base
<222>  (18)..(18)
<223>  2'-O-methyl modified

<220>  
<221>  modified_base
<222>  (19)..(19)
<223>  2'-O-methyl modified

<220>  
<221>  modified_base
<222>  (20)..(20)
<223>  2'-O-methyl modified

<220>  
<221>  modified_base
<222>  (21)..(21)
<223>  2'-O-methyl modified

<220>  
<221>  modified_base
<222>  (22)..(22)
<223>  2'-O-methyl modified

<220>  
<221>  modified_base
<222>  (23)..(23)
<223>  2'-O-methyl modified

<220>  
<221>  modified_base
<222>  (24)..(24)
<223>  2'-O-methyl modified

<220>  
<221>  modified_base
<222>  (25)..(25)
<223>  2'-O-methyl modified

<220>  
<221>  modified_base
<222>  (26)..(26)
<223>  2'-O-methyl modified

<220>  
<221>  modified_base
<222>  (27)..(27)
<223>  2'-O-methyl modified

<220>  
<221>  modified_base
<222>  (28)..(28)
<223>  GalNAc-conjugated
<220>  
<221>  modified_base
<222>  (29)..(29)
<223>  GalNAc-conjugated
<220>  
<221>  modified_base
<222>  (30)..(30)
<223>  GalNAc-conjugated
<220>  
<221>  modified_base
<222>  (31)..(31)
<223>  2'-O-methyl modified

<220>  
<221>  modified_base
<222>  (32)..(32)
<223>  2'-O-methyl modified

<220>  
<221>  modified_base
<222>  (33)..(33)
<223>  2'-O-methyl modified

<220>  
<221>  modified_base
<222>  (34)..(34)
<223>  2'-O-methyl modified

<220>  
<221>  modified_base
<222>  (35)..(35)
<223>  2'-O-methyl modified

<220>  
<221>  modified_base
<222>  (36)..(36)
<223>  2'-O-methyl modified

<400>  956
caccuuccuc aaggauuuca gcagccgaaa ggcugc                                 36


<210>  957
<211>  36
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  Modified sense strand


<220>
<221>  misc_feature
<222>  (1)..(2)
<223>  linked via phosphorothioate

<220>  
<221>  modified_base
<222>  (1)..(1)
<223>  2'-O-methyl modified

<220>  
<221>  modified_base
<222>  (2)..(2)
<223>  2'-O-methyl modified

<220>  
<221>  modified_base
<222>  (3)..(3)
<223>  2'-O-methyl modified

<220>  
<221>  modified_base
<222>  (4)..(4)
<223>  2'-O-methyl modified

<220>  
<221>  modified_base
<222>  (5)..(5)
<223>  2'-O-methyl modified

<220>  
<221>  modified_base
<222>  (6)..(6)
<223>  2'-O-methyl modified

<220>  
<221>  modified_base
<222>  (7)..(7)
<223>  2'-O-methyl modified

<220>  
<221>  modified_base
<222>  (8)..(8)
<223>  2'-fluoro modified

<220>  
<221>  modified_base
<222>  (9)..(9)
<223>  2'-fluoro modified

<220>  
<221>  modified_base
<222>  (10)..(10)
<223>  2'-fluoro modified

<220>  
<221>  modified_base
<222>  (11)..(11)
<223>  2'-fluoro modified

<220>  
<221>  modified_base
<222>  (12)..(12)
<223>  2'-O-methyl modified

<220>  
<221>  modified_base
<222>  (13)..(13)
<223>  2'-O-methyl modified

<220>  
<221>  modified_base
<222>  (14)..(14)
<223>  2'-O-methyl modified

<220>  
<221>  modified_base
<222>  (15)..(15)
<223>  2'-O-methyl modified

<220>  
<221>  modified_base
<222>  (16)..(16)
<223>  2'-O-methyl modified

<220>  
<221>  modified_base
<222>  (17)..(17)
<223>  2'-O-methyl modified

<220>  
<221>  modified_base
<222>  (18)..(18)
<223>  2'-O-methyl modified

<220>  
<221>  modified_base
<222>  (19)..(19)
<223>  2'-O-methyl modified

<220>  
<221>  modified_base
<222>  (20)..(20)
<223>  2'-O-methyl modified

<220>  
<221>  modified_base
<222>  (21)..(21)
<223>  2'-O-methyl modified

<220>  
<221>  modified_base
<222>  (22)..(22)
<223>  2'-O-methyl modified

<220>  
<221>  modified_base
<222>  (23)..(23)
<223>  2'-O-methyl modified

<220>  
<221>  modified_base
<222>  (24)..(24)
<223>  2'-O-methyl modified

<220>  
<221>  modified_base
<222>  (25)..(25)
<223>  2'-O-methyl modified

<220>  
<221>  modified_base
<222>  (26)..(26)
<223>  2'-O-methyl modified

<220>  
<221>  modified_base
<222>  (27)..(27)
<223>  2'-O-methyl modified

<220>  
<221>  modified_base
<222>  (28)..(28)
<223>  GalNAc-conjugated
<220>  
<221>  modified_base
<222>  (29)..(29)
<223>  GalNAc-conjugated
<220>  
<221>  modified_base
<222>  (30)..(30)
<223>  GalNAc-conjugated
<220>  
<221>  modified_base
<222>  (31)..(31)
<223>  2'-O-methyl modified

<220>  
<221>  modified_base
<222>  (32)..(32)
<223>  2'-O-methyl modified

<220>  
<221>  modified_base
<222>  (33)..(33)
<223>  2'-O-methyl modified

<220>  
<221>  modified_base
<222>  (34)..(34)
<223>  2'-O-methyl modified

<220>  
<221>  modified_base
<222>  (35)..(35)
<223>  2'-O-methyl modified

<220>  
<221>  modified_base
<222>  (36)..(36)
<223>  2'-O-methyl modified

<400>  957
accuuccuca aggauuucaa gcagccgaaa ggcugc                                 36


<210>  958
<211>  36
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  Modified sense strand


<220>
<221>  misc_feature
<222>  (1)..(2)
<223>  linked via phosphorothioate

<220>  
<221>  modified_base
<222>  (1)..(1)
<223>  2'-O-methyl modified

<220>  
<221>  modified_base
<222>  (2)..(2)
<223>  2'-O-methyl modified

<220>  
<221>  modified_base
<222>  (3)..(3)
<223>  2'-O-methyl modified

<220>  
<221>  modified_base
<222>  (4)..(4)
<223>  2'-O-methyl modified

<220>  
<221>  modified_base
<222>  (5)..(5)
<223>  2'-O-methyl modified

<220>  
<221>  modified_base
<222>  (6)..(6)
<223>  2'-O-methyl modified

<220>  
<221>  modified_base
<222>  (7)..(7)
<223>  2'-O-methyl modified

<220>  
<221>  modified_base
<222>  (8)..(8)
<223>  2'-fluoro modified

<220>  
<221>  modified_base
<222>  (9)..(9)
<223>  2'-fluoro modified

<220>  
<221>  modified_base
<222>  (10)..(10)
<223>  2'-fluoro modified

<220>  
<221>  modified_base
<222>  (11)..(11)
<223>  2'-fluoro modified

<220>  
<221>  modified_base
<222>  (12)..(12)
<223>  2'-O-methyl modified

<220>  
<221>  modified_base
<222>  (13)..(13)
<223>  2'-O-methyl modified

<220>  
<221>  modified_base
<222>  (14)..(14)
<223>  2'-O-methyl modified

<220>  
<221>  modified_base
<222>  (15)..(15)
<223>  2'-O-methyl modified

<220>  
<221>  modified_base
<222>  (16)..(16)
<223>  2'-O-methyl modified

<220>  
<221>  modified_base
<222>  (17)..(17)
<223>  2'-O-methyl modified

<220>  
<221>  modified_base
<222>  (18)..(18)
<223>  2'-O-methyl modified

<220>  
<221>  modified_base
<222>  (19)..(19)
<223>  2'-O-methyl modified

<220>  
<221>  modified_base
<222>  (20)..(20)
<223>  2'-O-methyl modified

<220>  
<221>  modified_base
<222>  (21)..(21)
<223>  2'-O-methyl modified

<220>  
<221>  modified_base
<222>  (22)..(22)
<223>  2'-O-methyl modified

<220>  
<221>  modified_base
<222>  (23)..(23)
<223>  2'-O-methyl modified

<220>  
<221>  modified_base
<222>  (24)..(24)
<223>  2'-O-methyl modified

<220>  
<221>  modified_base
<222>  (25)..(25)
<223>  2'-O-methyl modified

<220>  
<221>  modified_base
<222>  (26)..(26)
<223>  2'-O-methyl modified

<220>  
<221>  modified_base
<222>  (27)..(27)
<223>  2'-O-methyl modified

<220>  
<221>  modified_base
<222>  (28)..(28)
<223>  GalNAc-conjugated
<220>  
<221>  modified_base
<222>  (29)..(29)
<223>  GalNAc-conjugated
<220>  
<221>  modified_base
<222>  (30)..(30)
<223>  GalNAc-conjugated
<220>  
<221>  modified_base
<222>  (31)..(31)
<223>  2'-O-methyl modified

<220>  
<221>  modified_base
<222>  (32)..(32)
<223>  2'-O-methyl modified

<220>  
<221>  modified_base
<222>  (33)..(33)
<223>  2'-O-methyl modified

<220>  
<221>  modified_base
<222>  (34)..(34)
<223>  2'-O-methyl modified

<220>  
<221>  modified_base
<222>  (35)..(35)
<223>  2'-O-methyl modified

<220>  
<221>  modified_base
<222>  (36)..(36)
<223>  2'-O-methyl modified

<400>  958
ccuuccucaa ggauuucaga gcagccgaaa ggcugc                                 36


<210>  959
<211>  36
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  Modified sense strand


<220>
<221>  misc_feature
<222>  (1)..(2)
<223>  linked via phosphorothioate

<220>  
<221>  modified_base
<222>  (1)..(1)
<223>  2'-O-methyl modified

<220>  
<221>  modified_base
<222>  (2)..(2)
<223>  2'-O-methyl modified

<220>  
<221>  modified_base
<222>  (3)..(3)
<223>  2'-O-methyl modified

<220>  
<221>  modified_base
<222>  (4)..(4)
<223>  2'-O-methyl modified

<220>  
<221>  modified_base
<222>  (5)..(5)
<223>  2'-O-methyl modified

<220>  
<221>  modified_base
<222>  (6)..(6)
<223>  2'-O-methyl modified

<220>  
<221>  modified_base
<222>  (7)..(7)
<223>  2'-O-methyl modified

<220>  
<221>  modified_base
<222>  (8)..(8)
<223>  2'-fluoro modified

<220>  
<221>  modified_base
<222>  (9)..(9)
<223>  2'-fluoro modified

<220>  
<221>  modified_base
<222>  (10)..(10)
<223>  2'-fluoro modified

<220>  
<221>  modified_base
<222>  (11)..(11)
<223>  2'-fluoro modified

<220>  
<221>  modified_base
<222>  (12)..(12)
<223>  2'-O-methyl modified

<220>  
<221>  modified_base
<222>  (13)..(13)
<223>  2'-O-methyl modified

<220>  
<221>  modified_base
<222>  (14)..(14)
<223>  2'-O-methyl modified

<220>  
<221>  modified_base
<222>  (15)..(15)
<223>  2'-O-methyl modified

<220>  
<221>  modified_base
<222>  (16)..(16)
<223>  2'-O-methyl modified

<220>  
<221>  modified_base
<222>  (17)..(17)
<223>  2'-O-methyl modified

<220>  
<221>  modified_base
<222>  (18)..(18)
<223>  2'-O-methyl modified

<220>  
<221>  modified_base
<222>  (19)..(19)
<223>  2'-O-methyl modified

<220>  
<221>  modified_base
<222>  (20)..(20)
<223>  2'-O-methyl modified

<220>  
<221>  modified_base
<222>  (21)..(21)
<223>  2'-O-methyl modified

<220>  
<221>  modified_base
<222>  (22)..(22)
<223>  2'-O-methyl modified

<220>  
<221>  modified_base
<222>  (23)..(23)
<223>  2'-O-methyl modified

<220>  
<221>  modified_base
<222>  (24)..(24)
<223>  2'-O-methyl modified

<220>  
<221>  modified_base
<222>  (25)..(25)
<223>  2'-O-methyl modified

<220>  
<221>  modified_base
<222>  (26)..(26)
<223>  2'-O-methyl modified

<220>  
<221>  modified_base
<222>  (27)..(27)
<223>  2'-O-methyl modified

<220>  
<221>  modified_base
<222>  (28)..(28)
<223>  GalNAc-conjugated
<220>  
<221>  modified_base
<222>  (29)..(29)
<223>  GalNAc-conjugated
<220>  
<221>  modified_base
<222>  (30)..(30)
<223>  GalNAc-conjugated
<220>  
<221>  modified_base
<222>  (31)..(31)
<223>  2'-O-methyl modified

<220>  
<221>  modified_base
<222>  (32)..(32)
<223>  2'-O-methyl modified

<220>  
<221>  modified_base
<222>  (33)..(33)
<223>  2'-O-methyl modified

<220>  
<221>  modified_base
<222>  (34)..(34)
<223>  2'-O-methyl modified

<220>  
<221>  modified_base
<222>  (35)..(35)
<223>  2'-O-methyl modified

<220>  
<221>  modified_base
<222>  (36)..(36)
<223>  2'-O-methyl modified

<400>  959
cuuccucaag gauuucagua gcagccgaaa ggcugc                                 36


<210>  960
<211>  36
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  Modified sense strand


<220>
<221>  misc_feature
<222>  (1)..(2)
<223>  linked via phosphorothioate

<220>  
<221>  modified_base
<222>  (1)..(1)
<223>  2'-O-methyl modified

<220>  
<221>  modified_base
<222>  (2)..(2)
<223>  2'-O-methyl modified

<220>  
<221>  modified_base
<222>  (3)..(3)
<223>  2'-O-methyl modified

<220>  
<221>  modified_base
<222>  (4)..(4)
<223>  2'-O-methyl modified

<220>  
<221>  modified_base
<222>  (5)..(5)
<223>  2'-O-methyl modified

<220>  
<221>  modified_base
<222>  (6)..(6)
<223>  2'-O-methyl modified

<220>  
<221>  modified_base
<222>  (7)..(7)
<223>  2'-O-methyl modified

<220>  
<221>  modified_base
<222>  (8)..(8)
<223>  2'-fluoro modified

<220>  
<221>  modified_base
<222>  (9)..(9)
<223>  2'-fluoro modified

<220>  
<221>  modified_base
<222>  (10)..(10)
<223>  2'-fluoro modified

<220>  
<221>  modified_base
<222>  (11)..(11)
<223>  2'-fluoro modified

<220>  
<221>  modified_base
<222>  (12)..(12)
<223>  2'-O-methyl modified

<220>  
<221>  modified_base
<222>  (13)..(13)
<223>  2'-O-methyl modified

<220>  
<221>  modified_base
<222>  (14)..(14)
<223>  2'-O-methyl modified

<220>  
<221>  modified_base
<222>  (15)..(15)
<223>  2'-O-methyl modified

<220>  
<221>  modified_base
<222>  (16)..(16)
<223>  2'-O-methyl modified

<220>  
<221>  modified_base
<222>  (17)..(17)
<223>  2'-O-methyl modified

<220>  
<221>  modified_base
<222>  (18)..(18)
<223>  2'-O-methyl modified

<220>  
<221>  modified_base
<222>  (19)..(19)
<223>  2'-O-methyl modified

<220>  
<221>  modified_base
<222>  (20)..(20)
<223>  2'-O-methyl modified

<220>  
<221>  modified_base
<222>  (21)..(21)
<223>  2'-O-methyl modified

<220>  
<221>  modified_base
<222>  (22)..(22)
<223>  2'-O-methyl modified

<220>  
<221>  modified_base
<222>  (23)..(23)
<223>  2'-O-methyl modified

<220>  
<221>  modified_base
<222>  (24)..(24)
<223>  2'-O-methyl modified

<220>  
<221>  modified_base
<222>  (25)..(25)
<223>  2'-O-methyl modified

<220>  
<221>  modified_base
<222>  (26)..(26)
<223>  2'-O-methyl modified

<220>  
<221>  modified_base
<222>  (27)..(27)
<223>  2'-O-methyl modified

<220>  
<221>  modified_base
<222>  (28)..(28)
<223>  GalNAc-conjugated
<220>  
<221>  modified_base
<222>  (29)..(29)
<223>  GalNAc-conjugated
<220>  
<221>  modified_base
<222>  (30)..(30)
<223>  GalNAc-conjugated
<220>  
<221>  modified_base
<222>  (31)..(31)
<223>  2'-O-methyl modified

<220>  
<221>  modified_base
<222>  (32)..(32)
<223>  2'-O-methyl modified

<220>  
<221>  modified_base
<222>  (33)..(33)
<223>  2'-O-methyl modified

<220>  
<221>  modified_base
<222>  (34)..(34)
<223>  2'-O-methyl modified

<220>  
<221>  modified_base
<222>  (35)..(35)
<223>  2'-O-methyl modified

<220>  
<221>  modified_base
<222>  (36)..(36)
<223>  2'-O-methyl modified

<400>  960
uuccucaagg auuucaguua gcagccgaaa ggcugc                                 36


<210>  961
<211>  36
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  Modified sense strand


<220>
<221>  misc_feature
<222>  (1)..(2)
<223>  linked via phosphorothioate

<220>  
<221>  modified_base
<222>  (1)..(1)
<223>  2'-O-methyl modified

<220>  
<221>  modified_base
<222>  (2)..(2)
<223>  2'-O-methyl modified

<220>  
<221>  modified_base
<222>  (3)..(3)
<223>  2'-O-methyl modified

<220>  
<221>  modified_base
<222>  (4)..(4)
<223>  2'-O-methyl modified

<220>  
<221>  modified_base
<222>  (5)..(5)
<223>  2'-O-methyl modified

<220>  
<221>  modified_base
<222>  (6)..(6)
<223>  2'-O-methyl modified

<220>  
<221>  modified_base
<222>  (7)..(7)
<223>  2'-O-methyl modified

<220>  
<221>  modified_base
<222>  (8)..(8)
<223>  2'-fluoro modified

<220>  
<221>  modified_base
<222>  (9)..(9)
<223>  2'-fluoro modified

<220>  
<221>  modified_base
<222>  (10)..(10)
<223>  2'-fluoro modified

<220>  
<221>  modified_base
<222>  (11)..(11)
<223>  2'-fluoro modified

<220>  
<221>  modified_base
<222>  (12)..(12)
<223>  2'-O-methyl modified

<220>  
<221>  modified_base
<222>  (13)..(13)
<223>  2'-O-methyl modified

<220>  
<221>  modified_base
<222>  (14)..(14)
<223>  2'-O-methyl modified

<220>  
<221>  modified_base
<222>  (15)..(15)
<223>  2'-O-methyl modified

<220>  
<221>  modified_base
<222>  (16)..(16)
<223>  2'-O-methyl modified

<220>  
<221>  modified_base
<222>  (17)..(17)
<223>  2'-O-methyl modified

<220>  
<221>  modified_base
<222>  (18)..(18)
<223>  2'-O-methyl modified

<220>  
<221>  modified_base
<222>  (19)..(19)
<223>  2'-O-methyl modified

<220>  
<221>  modified_base
<222>  (20)..(20)
<223>  2'-O-methyl modified

<220>  
<221>  modified_base
<222>  (21)..(21)
<223>  2'-O-methyl modified

<220>  
<221>  modified_base
<222>  (22)..(22)
<223>  2'-O-methyl modified

<220>  
<221>  modified_base
<222>  (23)..(23)
<223>  2'-O-methyl modified

<220>  
<221>  modified_base
<222>  (24)..(24)
<223>  2'-O-methyl modified

<220>  
<221>  modified_base
<222>  (25)..(25)
<223>  2'-O-methyl modified

<220>  
<221>  modified_base
<222>  (26)..(26)
<223>  2'-O-methyl modified

<220>  
<221>  modified_base
<222>  (27)..(27)
<223>  2'-O-methyl modified

<220>  
<221>  modified_base
<222>  (28)..(28)
<223>  GalNAc-conjugated
<220>  
<221>  modified_base
<222>  (29)..(29)
<223>  GalNAc-conjugated
<220>  
<221>  modified_base
<222>  (30)..(30)
<223>  GalNAc-conjugated
<220>  
<221>  modified_base
<222>  (31)..(31)
<223>  2'-O-methyl modified

<220>  
<221>  modified_base
<222>  (32)..(32)
<223>  2'-O-methyl modified

<220>  
<221>  modified_base
<222>  (33)..(33)
<223>  2'-O-methyl modified

<220>  
<221>  modified_base
<222>  (34)..(34)
<223>  2'-O-methyl modified

<220>  
<221>  modified_base
<222>  (35)..(35)
<223>  2'-O-methyl modified

<220>  
<221>  modified_base
<222>  (36)..(36)
<223>  2'-O-methyl modified

<400>  961
uccucaagga uuucaguuaa gcagccgaaa ggcugc                                 36


<210>  962
<211>  36
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  Modified sense strand


<220>
<221>  misc_feature
<222>  (1)..(2)
<223>  linked via phosphorothioate

<220>  
<221>  modified_base
<222>  (1)..(1)
<223>  2'-O-methyl modified

<220>  
<221>  modified_base
<222>  (2)..(2)
<223>  2'-O-methyl modified

<220>  
<221>  modified_base
<222>  (3)..(3)
<223>  2'-O-methyl modified

<220>  
<221>  modified_base
<222>  (4)..(4)
<223>  2'-O-methyl modified

<220>  
<221>  modified_base
<222>  (5)..(5)
<223>  2'-O-methyl modified

<220>  
<221>  modified_base
<222>  (6)..(6)
<223>  2'-O-methyl modified

<220>  
<221>  modified_base
<222>  (7)..(7)
<223>  2'-O-methyl modified

<220>  
<221>  modified_base
<222>  (8)..(8)
<223>  2'-fluoro modified

<220>  
<221>  modified_base
<222>  (9)..(9)
<223>  2'-fluoro modified

<220>  
<221>  modified_base
<222>  (10)..(10)
<223>  2'-fluoro modified

<220>  
<221>  modified_base
<222>  (11)..(11)
<223>  2'-fluoro modified

<220>  
<221>  modified_base
<222>  (12)..(12)
<223>  2'-O-methyl modified

<220>  
<221>  modified_base
<222>  (13)..(13)
<223>  2'-O-methyl modified

<220>  
<221>  modified_base
<222>  (14)..(14)
<223>  2'-O-methyl modified

<220>  
<221>  modified_base
<222>  (15)..(15)
<223>  2'-O-methyl modified

<220>  
<221>  modified_base
<222>  (16)..(16)
<223>  2'-O-methyl modified

<220>  
<221>  modified_base
<222>  (17)..(17)
<223>  2'-O-methyl modified

<220>  
<221>  modified_base
<222>  (18)..(18)
<223>  2'-O-methyl modified

<220>  
<221>  modified_base
<222>  (19)..(19)
<223>  2'-O-methyl modified

<220>  
<221>  modified_base
<222>  (20)..(20)
<223>  2'-O-methyl modified

<220>  
<221>  modified_base
<222>  (21)..(21)
<223>  2'-O-methyl modified

<220>  
<221>  modified_base
<222>  (22)..(22)
<223>  2'-O-methyl modified

<220>  
<221>  modified_base
<222>  (23)..(23)
<223>  2'-O-methyl modified

<220>  
<221>  modified_base
<222>  (24)..(24)
<223>  2'-O-methyl modified

<220>  
<221>  modified_base
<222>  (25)..(25)
<223>  2'-O-methyl modified

<220>  
<221>  modified_base
<222>  (26)..(26)
<223>  2'-O-methyl modified

<220>  
<221>  modified_base
<222>  (27)..(27)
<223>  2'-O-methyl modified

<220>  
<221>  modified_base
<222>  (28)..(28)
<223>  GalNAc-conjugated
<220>  
<221>  modified_base
<222>  (29)..(29)
<223>  GalNAc-conjugated
<220>  
<221>  modified_base
<222>  (30)..(30)
<223>  GalNAc-conjugated
<220>  
<221>  modified_base
<222>  (31)..(31)
<223>  2'-O-methyl modified

<220>  
<221>  modified_base
<222>  (32)..(32)
<223>  2'-O-methyl modified

<220>  
<221>  modified_base
<222>  (33)..(33)
<223>  2'-O-methyl modified

<220>  
<221>  modified_base
<222>  (34)..(34)
<223>  2'-O-methyl modified

<220>  
<221>  modified_base
<222>  (35)..(35)
<223>  2'-O-methyl modified

<220>  
<221>  modified_base
<222>  (36)..(36)
<223>  2'-O-methyl modified

<400>  962
ccucaaggau uucaguuaua gcagccgaaa ggcugc                                 36


<210>  963
<211>  36
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  Modified sense strand


<220>
<221>  misc_feature
<222>  (1)..(2)
<223>  linked via phosphorothioate

<220>  
<221>  modified_base
<222>  (1)..(1)
<223>  2'-O-methyl modified

<220>  
<221>  modified_base
<222>  (2)..(2)
<223>  2'-O-methyl modified

<220>  
<221>  modified_base
<222>  (3)..(3)
<223>  2'-O-methyl modified

<220>  
<221>  modified_base
<222>  (4)..(4)
<223>  2'-O-methyl modified

<220>  
<221>  modified_base
<222>  (5)..(5)
<223>  2'-O-methyl modified

<220>  
<221>  modified_base
<222>  (6)..(6)
<223>  2'-O-methyl modified

<220>  
<221>  modified_base
<222>  (7)..(7)
<223>  2'-O-methyl modified

<220>  
<221>  modified_base
<222>  (8)..(8)
<223>  2'-fluoro modified

<220>  
<221>  modified_base
<222>  (9)..(9)
<223>  2'-fluoro modified

<220>  
<221>  modified_base
<222>  (10)..(10)
<223>  2'-fluoro modified

<220>  
<221>  modified_base
<222>  (11)..(11)
<223>  2'-fluoro modified

<220>  
<221>  modified_base
<222>  (12)..(12)
<223>  2'-O-methyl modified

<220>  
<221>  modified_base
<222>  (13)..(13)
<223>  2'-O-methyl modified

<220>  
<221>  modified_base
<222>  (14)..(14)
<223>  2'-O-methyl modified

<220>  
<221>  modified_base
<222>  (15)..(15)
<223>  2'-O-methyl modified

<220>  
<221>  modified_base
<222>  (16)..(16)
<223>  2'-O-methyl modified

<220>  
<221>  modified_base
<222>  (17)..(17)
<223>  2'-O-methyl modified

<220>  
<221>  modified_base
<222>  (18)..(18)
<223>  2'-O-methyl modified

<220>  
<221>  modified_base
<222>  (19)..(19)
<223>  2'-O-methyl modified

<220>  
<221>  modified_base
<222>  (20)..(20)
<223>  2'-O-methyl modified

<220>  
<221>  modified_base
<222>  (21)..(21)
<223>  2'-O-methyl modified

<220>  
<221>  modified_base
<222>  (22)..(22)
<223>  2'-O-methyl modified

<220>  
<221>  modified_base
<222>  (23)..(23)
<223>  2'-O-methyl modified

<220>  
<221>  modified_base
<222>  (24)..(24)
<223>  2'-O-methyl modified

<220>  
<221>  modified_base
<222>  (25)..(25)
<223>  2'-O-methyl modified

<220>  
<221>  modified_base
<222>  (26)..(26)
<223>  2'-O-methyl modified

<220>  
<221>  modified_base
<222>  (27)..(27)
<223>  2'-O-methyl modified

<220>  
<221>  modified_base
<222>  (28)..(28)
<223>  GalNAc-conjugated
<220>  
<221>  modified_base
<222>  (29)..(29)
<223>  GalNAc-conjugated
<220>  
<221>  modified_base
<222>  (30)..(30)
<223>  GalNAc-conjugated
<220>  
<221>  modified_base
<222>  (31)..(31)
<223>  2'-O-methyl modified

<220>  
<221>  modified_base
<222>  (32)..(32)
<223>  2'-O-methyl modified

<220>  
<221>  modified_base
<222>  (33)..(33)
<223>  2'-O-methyl modified

<220>  
<221>  modified_base
<222>  (34)..(34)
<223>  2'-O-methyl modified

<220>  
<221>  modified_base
<222>  (35)..(35)
<223>  2'-O-methyl modified

<220>  
<221>  modified_base
<222>  (36)..(36)
<223>  2'-O-methyl modified

<400>  963
cucaaggauu ucaguuauaa gcagccgaaa ggcugc                                 36


<210>  964
<211>  36
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  Modified sense strand


<220>
<221>  misc_feature
<222>  (1)..(2)
<223>  linked via phosphorothioate

<220>  
<221>  modified_base
<222>  (1)..(1)
<223>  2'-O-methyl modified

<220>  
<221>  modified_base
<222>  (2)..(2)
<223>  2'-O-methyl modified

<220>  
<221>  modified_base
<222>  (3)..(3)
<223>  2'-O-methyl modified

<220>  
<221>  modified_base
<222>  (4)..(4)
<223>  2'-O-methyl modified

<220>  
<221>  modified_base
<222>  (5)..(5)
<223>  2'-O-methyl modified

<220>  
<221>  modified_base
<222>  (6)..(6)
<223>  2'-O-methyl modified

<220>  
<221>  modified_base
<222>  (7)..(7)
<223>  2'-O-methyl modified

<220>  
<221>  modified_base
<222>  (8)..(8)
<223>  2'-fluoro modified

<220>  
<221>  modified_base
<222>  (9)..(9)
<223>  2'-fluoro modified

<220>  
<221>  modified_base
<222>  (10)..(10)
<223>  2'-fluoro modified

<220>  
<221>  modified_base
<222>  (11)..(11)
<223>  2'-fluoro modified

<220>  
<221>  modified_base
<222>  (12)..(12)
<223>  2'-O-methyl modified

<220>  
<221>  modified_base
<222>  (13)..(13)
<223>  2'-O-methyl modified

<220>  
<221>  modified_base
<222>  (14)..(14)
<223>  2'-O-methyl modified

<220>  
<221>  modified_base
<222>  (15)..(15)
<223>  2'-O-methyl modified

<220>  
<221>  modified_base
<222>  (16)..(16)
<223>  2'-O-methyl modified

<220>  
<221>  modified_base
<222>  (17)..(17)
<223>  2'-O-methyl modified

<220>  
<221>  modified_base
<222>  (18)..(18)
<223>  2'-O-methyl modified

<220>  
<221>  modified_base
<222>  (19)..(19)
<223>  2'-O-methyl modified

<220>  
<221>  modified_base
<222>  (20)..(20)
<223>  2'-O-methyl modified

<220>  
<221>  modified_base
<222>  (21)..(21)
<223>  2'-O-methyl modified

<220>  
<221>  modified_base
<222>  (22)..(22)
<223>  2'-O-methyl modified

<220>  
<221>  modified_base
<222>  (23)..(23)
<223>  2'-O-methyl modified

<220>  
<221>  modified_base
<222>  (24)..(24)
<223>  2'-O-methyl modified

<220>  
<221>  modified_base
<222>  (25)..(25)
<223>  2'-O-methyl modified

<220>  
<221>  modified_base
<222>  (26)..(26)
<223>  2'-O-methyl modified

<220>  
<221>  modified_base
<222>  (27)..(27)
<223>  2'-O-methyl modified

<220>  
<221>  modified_base
<222>  (28)..(28)
<223>  GalNAc-conjugated
<220>  
<221>  modified_base
<222>  (29)..(29)
<223>  GalNAc-conjugated
<220>  
<221>  modified_base
<222>  (30)..(30)
<223>  GalNAc-conjugated
<220>  
<221>  modified_base
<222>  (31)..(31)
<223>  2'-O-methyl modified

<220>  
<221>  modified_base
<222>  (32)..(32)
<223>  2'-O-methyl modified

<220>  
<221>  modified_base
<222>  (33)..(33)
<223>  2'-O-methyl modified

<220>  
<221>  modified_base
<222>  (34)..(34)
<223>  2'-O-methyl modified

<220>  
<221>  modified_base
<222>  (35)..(35)
<223>  2'-O-methyl modified

<220>  
<221>  modified_base
<222>  (36)..(36)
<223>  2'-O-methyl modified

<400>  964
ucaaggauuu caguuauaaa gcagccgaaa ggcugc                                 36


<210>  965
<211>  36
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  Modified sense strand


<220>
<221>  misc_feature
<222>  (1)..(2)
<223>  linked via phosphorothioate

<220>  
<221>  modified_base
<222>  (1)..(1)
<223>  2'-O-methyl modified

<220>  
<221>  modified_base
<222>  (2)..(2)
<223>  2'-O-methyl modified

<220>  
<221>  modified_base
<222>  (3)..(3)
<223>  2'-O-methyl modified

<220>  
<221>  modified_base
<222>  (4)..(4)
<223>  2'-O-methyl modified

<220>  
<221>  modified_base
<222>  (5)..(5)
<223>  2'-O-methyl modified

<220>  
<221>  modified_base
<222>  (6)..(6)
<223>  2'-O-methyl modified

<220>  
<221>  modified_base
<222>  (7)..(7)
<223>  2'-O-methyl modified

<220>  
<221>  modified_base
<222>  (8)..(8)
<223>  2'-fluoro modified

<220>  
<221>  modified_base
<222>  (9)..(9)
<223>  2'-fluoro modified

<220>  
<221>  modified_base
<222>  (10)..(10)
<223>  2'-fluoro modified

<220>  
<221>  modified_base
<222>  (11)..(11)
<223>  2'-fluoro modified

<220>  
<221>  modified_base
<222>  (12)..(12)
<223>  2'-O-methyl modified

<220>  
<221>  modified_base
<222>  (13)..(13)
<223>  2'-O-methyl modified

<220>  
<221>  modified_base
<222>  (14)..(14)
<223>  2'-O-methyl modified

<220>  
<221>  modified_base
<222>  (15)..(15)
<223>  2'-O-methyl modified

<220>  
<221>  modified_base
<222>  (16)..(16)
<223>  2'-O-methyl modified

<220>  
<221>  modified_base
<222>  (17)..(17)
<223>  2'-O-methyl modified

<220>  
<221>  modified_base
<222>  (18)..(18)
<223>  2'-O-methyl modified

<220>  
<221>  modified_base
<222>  (19)..(19)
<223>  2'-O-methyl modified

<220>  
<221>  modified_base
<222>  (20)..(20)
<223>  2'-O-methyl modified

<220>  
<221>  modified_base
<222>  (21)..(21)
<223>  2'-O-methyl modified

<220>  
<221>  modified_base
<222>  (22)..(22)
<223>  2'-O-methyl modified

<220>  
<221>  modified_base
<222>  (23)..(23)
<223>  2'-O-methyl modified

<220>  
<221>  modified_base
<222>  (24)..(24)
<223>  2'-O-methyl modified

<220>  
<221>  modified_base
<222>  (25)..(25)
<223>  2'-O-methyl modified

<220>  
<221>  modified_base
<222>  (26)..(26)
<223>  2'-O-methyl modified

<220>  
<221>  modified_base
<222>  (27)..(27)
<223>  2'-O-methyl modified

<220>  
<221>  modified_base
<222>  (28)..(28)
<223>  GalNAc-conjugated
<220>  
<221>  modified_base
<222>  (29)..(29)
<223>  GalNAc-conjugated
<220>  
<221>  modified_base
<222>  (30)..(30)
<223>  GalNAc-conjugated
<220>  
<221>  modified_base
<222>  (31)..(31)
<223>  2'-O-methyl modified

<220>  
<221>  modified_base
<222>  (32)..(32)
<223>  2'-O-methyl modified

<220>  
<221>  modified_base
<222>  (33)..(33)
<223>  2'-O-methyl modified

<220>  
<221>  modified_base
<222>  (34)..(34)
<223>  2'-O-methyl modified

<220>  
<221>  modified_base
<222>  (35)..(35)
<223>  2'-O-methyl modified

<220>  
<221>  modified_base
<222>  (36)..(36)
<223>  2'-O-methyl modified

<400>  965
caaggauuuc aguuauaaca gcagccgaaa ggcugc                                 36


<210>  966
<211>  36
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  Modified sense strand


<220>
<221>  misc_feature
<222>  (1)..(2)
<223>  linked via phosphorothioate

<220>  
<221>  modified_base
<222>  (1)..(1)
<223>  2'-O-methyl modified

<220>  
<221>  modified_base
<222>  (2)..(2)
<223>  2'-O-methyl modified

<220>  
<221>  modified_base
<222>  (3)..(3)
<223>  2'-O-methyl modified

<220>  
<221>  modified_base
<222>  (4)..(4)
<223>  2'-O-methyl modified

<220>  
<221>  modified_base
<222>  (5)..(5)
<223>  2'-O-methyl modified

<220>  
<221>  modified_base
<222>  (6)..(6)
<223>  2'-O-methyl modified

<220>  
<221>  modified_base
<222>  (7)..(7)
<223>  2'-O-methyl modified

<220>  
<221>  modified_base
<222>  (8)..(8)
<223>  2'-fluoro modified

<220>  
<221>  modified_base
<222>  (9)..(9)
<223>  2'-fluoro modified

<220>  
<221>  modified_base
<222>  (10)..(10)
<223>  2'-fluoro modified

<220>  
<221>  modified_base
<222>  (11)..(11)
<223>  2'-fluoro modified

<220>  
<221>  modified_base
<222>  (12)..(12)
<223>  2'-O-methyl modified

<220>  
<221>  modified_base
<222>  (13)..(13)
<223>  2'-O-methyl modified

<220>  
<221>  modified_base
<222>  (14)..(14)
<223>  2'-O-methyl modified

<220>  
<221>  modified_base
<222>  (15)..(15)
<223>  2'-O-methyl modified

<220>  
<221>  modified_base
<222>  (16)..(16)
<223>  2'-O-methyl modified

<220>  
<221>  modified_base
<222>  (17)..(17)
<223>  2'-O-methyl modified

<220>  
<221>  modified_base
<222>  (18)..(18)
<223>  2'-O-methyl modified

<220>  
<221>  modified_base
<222>  (19)..(19)
<223>  2'-O-methyl modified

<220>  
<221>  modified_base
<222>  (20)..(20)
<223>  2'-O-methyl modified

<220>  
<221>  modified_base
<222>  (21)..(21)
<223>  2'-O-methyl modified

<220>  
<221>  modified_base
<222>  (22)..(22)
<223>  2'-O-methyl modified

<220>  
<221>  modified_base
<222>  (23)..(23)
<223>  2'-O-methyl modified

<220>  
<221>  modified_base
<222>  (24)..(24)
<223>  2'-O-methyl modified

<220>  
<221>  modified_base
<222>  (25)..(25)
<223>  2'-O-methyl modified

<220>  
<221>  modified_base
<222>  (26)..(26)
<223>  2'-O-methyl modified

<220>  
<221>  modified_base
<222>  (27)..(27)
<223>  2'-O-methyl modified

<220>  
<221>  modified_base
<222>  (28)..(28)
<223>  GalNAc-conjugated
<220>  
<221>  modified_base
<222>  (29)..(29)
<223>  GalNAc-conjugated
<220>  
<221>  modified_base
<222>  (30)..(30)
<223>  GalNAc-conjugated
<220>  
<221>  modified_base
<222>  (31)..(31)
<223>  2'-O-methyl modified

<220>  
<221>  modified_base
<222>  (32)..(32)
<223>  2'-O-methyl modified

<220>  
<221>  modified_base
<222>  (33)..(33)
<223>  2'-O-methyl modified

<220>  
<221>  modified_base
<222>  (34)..(34)
<223>  2'-O-methyl modified

<220>  
<221>  modified_base
<222>  (35)..(35)
<223>  2'-O-methyl modified

<220>  
<221>  modified_base
<222>  (36)..(36)
<223>  2'-O-methyl modified

<400>  966
aaggauuuca guuauaacca gcagccgaaa ggcugc                                 36


<210>  967
<211>  36
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  Modified sense strand


<220>
<221>  misc_feature
<222>  (1)..(2)
<223>  linked via phosphorothioate

<220>  
<221>  modified_base
<222>  (1)..(1)
<223>  2'-O-methyl modified

<220>  
<221>  modified_base
<222>  (2)..(2)
<223>  2'-O-methyl modified

<220>  
<221>  modified_base
<222>  (3)..(3)
<223>  2'-O-methyl modified

<220>  
<221>  modified_base
<222>  (4)..(4)
<223>  2'-O-methyl modified

<220>  
<221>  modified_base
<222>  (5)..(5)
<223>  2'-O-methyl modified

<220>  
<221>  modified_base
<222>  (6)..(6)
<223>  2'-O-methyl modified

<220>  
<221>  modified_base
<222>  (7)..(7)
<223>  2'-O-methyl modified

<220>  
<221>  modified_base
<222>  (8)..(8)
<223>  2'-fluoro modified

<220>  
<221>  modified_base
<222>  (9)..(9)
<223>  2'-fluoro modified

<220>  
<221>  modified_base
<222>  (10)..(10)
<223>  2'-fluoro modified

<220>  
<221>  modified_base
<222>  (11)..(11)
<223>  2'-fluoro modified

<220>  
<221>  modified_base
<222>  (12)..(12)
<223>  2'-O-methyl modified

<220>  
<221>  modified_base
<222>  (13)..(13)
<223>  2'-O-methyl modified

<220>  
<221>  modified_base
<222>  (14)..(14)
<223>  2'-O-methyl modified

<220>  
<221>  modified_base
<222>  (15)..(15)
<223>  2'-O-methyl modified

<220>  
<221>  modified_base
<222>  (16)..(16)
<223>  2'-O-methyl modified

<220>  
<221>  modified_base
<222>  (17)..(17)
<223>  2'-O-methyl modified

<220>  
<221>  modified_base
<222>  (18)..(18)
<223>  2'-O-methyl modified

<220>  
<221>  modified_base
<222>  (19)..(19)
<223>  2'-O-methyl modified

<220>  
<221>  modified_base
<222>  (20)..(20)
<223>  2'-O-methyl modified

<220>  
<221>  modified_base
<222>  (21)..(21)
<223>  2'-O-methyl modified

<220>  
<221>  modified_base
<222>  (22)..(22)
<223>  2'-O-methyl modified

<220>  
<221>  modified_base
<222>  (23)..(23)
<223>  2'-O-methyl modified

<220>  
<221>  modified_base
<222>  (24)..(24)
<223>  2'-O-methyl modified

<220>  
<221>  modified_base
<222>  (25)..(25)
<223>  2'-O-methyl modified

<220>  
<221>  modified_base
<222>  (26)..(26)
<223>  2'-O-methyl modified

<220>  
<221>  modified_base
<222>  (27)..(27)
<223>  2'-O-methyl modified

<220>  
<221>  modified_base
<222>  (28)..(28)
<223>  GalNAc-conjugated
<220>  
<221>  modified_base
<222>  (29)..(29)
<223>  GalNAc-conjugated
<220>  
<221>  modified_base
<222>  (30)..(30)
<223>  GalNAc-conjugated
<220>  
<221>  modified_base
<222>  (31)..(31)
<223>  2'-O-methyl modified

<220>  
<221>  modified_base
<222>  (32)..(32)
<223>  2'-O-methyl modified

<220>  
<221>  modified_base
<222>  (33)..(33)
<223>  2'-O-methyl modified

<220>  
<221>  modified_base
<222>  (34)..(34)
<223>  2'-O-methyl modified

<220>  
<221>  modified_base
<222>  (35)..(35)
<223>  2'-O-methyl modified

<220>  
<221>  modified_base
<222>  (36)..(36)
<223>  2'-O-methyl modified

<400>  967
aggauuucag uuauaaccga gcagccgaaa ggcugc                                 36


<210>  968
<211>  36
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  Modified sense strand


<220>
<221>  misc_feature
<222>  (1)..(2)
<223>  linked via phosphorothioate

<220>  
<221>  modified_base
<222>  (1)..(1)
<223>  2'-O-methyl modified

<220>  
<221>  modified_base
<222>  (2)..(2)
<223>  2'-O-methyl modified

<220>  
<221>  modified_base
<222>  (3)..(3)
<223>  2'-O-methyl modified

<220>  
<221>  modified_base
<222>  (4)..(4)
<223>  2'-O-methyl modified

<220>  
<221>  modified_base
<222>  (5)..(5)
<223>  2'-O-methyl modified

<220>  
<221>  modified_base
<222>  (6)..(6)
<223>  2'-O-methyl modified

<220>  
<221>  modified_base
<222>  (7)..(7)
<223>  2'-O-methyl modified

<220>  
<221>  modified_base
<222>  (8)..(8)
<223>  2'-fluoro modified

<220>  
<221>  modified_base
<222>  (9)..(9)
<223>  2'-fluoro modified

<220>  
<221>  modified_base
<222>  (10)..(10)
<223>  2'-fluoro modified

<220>  
<221>  modified_base
<222>  (11)..(11)
<223>  2'-fluoro modified

<220>  
<221>  modified_base
<222>  (12)..(12)
<223>  2'-O-methyl modified

<220>  
<221>  modified_base
<222>  (13)..(13)
<223>  2'-O-methyl modified

<220>  
<221>  modified_base
<222>  (14)..(14)
<223>  2'-O-methyl modified

<220>  
<221>  modified_base
<222>  (15)..(15)
<223>  2'-O-methyl modified

<220>  
<221>  modified_base
<222>  (16)..(16)
<223>  2'-O-methyl modified

<220>  
<221>  modified_base
<222>  (17)..(17)
<223>  2'-O-methyl modified

<220>  
<221>  modified_base
<222>  (18)..(18)
<223>  2'-O-methyl modified

<220>  
<221>  modified_base
<222>  (19)..(19)
<223>  2'-O-methyl modified

<220>  
<221>  modified_base
<222>  (20)..(20)
<223>  2'-O-methyl modified

<220>  
<221>  modified_base
<222>  (21)..(21)
<223>  2'-O-methyl modified

<220>  
<221>  modified_base
<222>  (22)..(22)
<223>  2'-O-methyl modified

<220>  
<221>  modified_base
<222>  (23)..(23)
<223>  2'-O-methyl modified

<220>  
<221>  modified_base
<222>  (24)..(24)
<223>  2'-O-methyl modified

<220>  
<221>  modified_base
<222>  (25)..(25)
<223>  2'-O-methyl modified

<220>  
<221>  modified_base
<222>  (26)..(26)
<223>  2'-O-methyl modified

<220>  
<221>  modified_base
<222>  (27)..(27)
<223>  2'-O-methyl modified

<220>  
<221>  modified_base
<222>  (28)..(28)
<223>  GalNAc-conjugated
<220>  
<221>  modified_base
<222>  (29)..(29)
<223>  GalNAc-conjugated
<220>  
<221>  modified_base
<222>  (30)..(30)
<223>  GalNAc-conjugated
<220>  
<221>  modified_base
<222>  (31)..(31)
<223>  2'-O-methyl modified

<220>  
<221>  modified_base
<222>  (32)..(32)
<223>  2'-O-methyl modified

<220>  
<221>  modified_base
<222>  (33)..(33)
<223>  2'-O-methyl modified

<220>  
<221>  modified_base
<222>  (34)..(34)
<223>  2'-O-methyl modified

<220>  
<221>  modified_base
<222>  (35)..(35)
<223>  2'-O-methyl modified

<220>  
<221>  modified_base
<222>  (36)..(36)
<223>  2'-O-methyl modified

<400>  968
ggauuucagu uauaaccgga gcagccgaaa ggcugc                                 36


<210>  969
<211>  36
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  Modified sense strand


<220>
<221>  misc_feature
<222>  (1)..(2)
<223>  linked via phosphorothioate

<220>  
<221>  modified_base
<222>  (1)..(1)
<223>  2'-O-methyl modified

<220>  
<221>  modified_base
<222>  (2)..(2)
<223>  2'-O-methyl modified

<220>  
<221>  modified_base
<222>  (3)..(3)
<223>  2'-O-methyl modified

<220>  
<221>  modified_base
<222>  (4)..(4)
<223>  2'-O-methyl modified

<220>  
<221>  modified_base
<222>  (5)..(5)
<223>  2'-O-methyl modified

<220>  
<221>  modified_base
<222>  (6)..(6)
<223>  2'-O-methyl modified

<220>  
<221>  modified_base
<222>  (7)..(7)
<223>  2'-O-methyl modified

<220>  
<221>  modified_base
<222>  (8)..(8)
<223>  2'-fluoro modified

<220>  
<221>  modified_base
<222>  (9)..(9)
<223>  2'-fluoro modified

<220>  
<221>  modified_base
<222>  (10)..(10)
<223>  2'-fluoro modified

<220>  
<221>  modified_base
<222>  (11)..(11)
<223>  2'-fluoro modified

<220>  
<221>  modified_base
<222>  (12)..(12)
<223>  2'-O-methyl modified

<220>  
<221>  modified_base
<222>  (13)..(13)
<223>  2'-O-methyl modified

<220>  
<221>  modified_base
<222>  (14)..(14)
<223>  2'-O-methyl modified

<220>  
<221>  modified_base
<222>  (15)..(15)
<223>  2'-O-methyl modified

<220>  
<221>  modified_base
<222>  (16)..(16)
<223>  2'-O-methyl modified

<220>  
<221>  modified_base
<222>  (17)..(17)
<223>  2'-O-methyl modified

<220>  
<221>  modified_base
<222>  (18)..(18)
<223>  2'-O-methyl modified

<220>  
<221>  modified_base
<222>  (19)..(19)
<223>  2'-O-methyl modified

<220>  
<221>  modified_base
<222>  (20)..(20)
<223>  2'-O-methyl modified

<220>  
<221>  modified_base
<222>  (21)..(21)
<223>  2'-O-methyl modified

<220>  
<221>  modified_base
<222>  (22)..(22)
<223>  2'-O-methyl modified

<220>  
<221>  modified_base
<222>  (23)..(23)
<223>  2'-O-methyl modified

<220>  
<221>  modified_base
<222>  (24)..(24)
<223>  2'-O-methyl modified

<220>  
<221>  modified_base
<222>  (25)..(25)
<223>  2'-O-methyl modified

<220>  
<221>  modified_base
<222>  (26)..(26)
<223>  2'-O-methyl modified

<220>  
<221>  modified_base
<222>  (27)..(27)
<223>  2'-O-methyl modified

<220>  
<221>  modified_base
<222>  (28)..(28)
<223>  GalNAc-conjugated
<220>  
<221>  modified_base
<222>  (29)..(29)
<223>  GalNAc-conjugated
<220>  
<221>  modified_base
<222>  (30)..(30)
<223>  GalNAc-conjugated
<220>  
<221>  modified_base
<222>  (31)..(31)
<223>  2'-O-methyl modified

<220>  
<221>  modified_base
<222>  (32)..(32)
<223>  2'-O-methyl modified

<220>  
<221>  modified_base
<222>  (33)..(33)
<223>  2'-O-methyl modified

<220>  
<221>  modified_base
<222>  (34)..(34)
<223>  2'-O-methyl modified

<220>  
<221>  modified_base
<222>  (35)..(35)
<223>  2'-O-methyl modified

<220>  
<221>  modified_base
<222>  (36)..(36)
<223>  2'-O-methyl modified

<400>  969
caguuauaac cgggaagaca gcagccgaaa ggcugc                                 36


<210>  970
<211>  36
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  Modified sense strand


<220>
<221>  misc_feature
<222>  (1)..(2)
<223>  linked via phosphorothioate

<220>  
<221>  modified_base
<222>  (1)..(1)
<223>  2'-O-methyl modified

<220>  
<221>  modified_base
<222>  (2)..(2)
<223>  2'-O-methyl modified

<220>  
<221>  modified_base
<222>  (3)..(3)
<223>  2'-O-methyl modified

<220>  
<221>  modified_base
<222>  (4)..(4)
<223>  2'-O-methyl modified

<220>  
<221>  modified_base
<222>  (5)..(5)
<223>  2'-O-methyl modified

<220>  
<221>  modified_base
<222>  (6)..(6)
<223>  2'-O-methyl modified

<220>  
<221>  modified_base
<222>  (7)..(7)
<223>  2'-O-methyl modified

<220>  
<221>  modified_base
<222>  (8)..(8)
<223>  2'-fluoro modified

<220>  
<221>  modified_base
<222>  (9)..(9)
<223>  2'-fluoro modified

<220>  
<221>  modified_base
<222>  (10)..(10)
<223>  2'-fluoro modified

<220>  
<221>  modified_base
<222>  (11)..(11)
<223>  2'-fluoro modified

<220>  
<221>  modified_base
<222>  (12)..(12)
<223>  2'-O-methyl modified

<220>  
<221>  modified_base
<222>  (13)..(13)
<223>  2'-O-methyl modified

<220>  
<221>  modified_base
<222>  (14)..(14)
<223>  2'-O-methyl modified

<220>  
<221>  modified_base
<222>  (15)..(15)
<223>  2'-O-methyl modified

<220>  
<221>  modified_base
<222>  (16)..(16)
<223>  2'-O-methyl modified

<220>  
<221>  modified_base
<222>  (17)..(17)
<223>  2'-O-methyl modified

<220>  
<221>  modified_base
<222>  (18)..(18)
<223>  2'-O-methyl modified

<220>  
<221>  modified_base
<222>  (19)..(19)
<223>  2'-O-methyl modified

<220>  
<221>  modified_base
<222>  (20)..(20)
<223>  2'-O-methyl modified

<220>  
<221>  modified_base
<222>  (21)..(21)
<223>  2'-O-methyl modified

<220>  
<221>  modified_base
<222>  (22)..(22)
<223>  2'-O-methyl modified

<220>  
<221>  modified_base
<222>  (23)..(23)
<223>  2'-O-methyl modified

<220>  
<221>  modified_base
<222>  (24)..(24)
<223>  2'-O-methyl modified

<220>  
<221>  modified_base
<222>  (25)..(25)
<223>  2'-O-methyl modified

<220>  
<221>  modified_base
<222>  (26)..(26)
<223>  2'-O-methyl modified

<220>  
<221>  modified_base
<222>  (27)..(27)
<223>  2'-O-methyl modified

<220>  
<221>  modified_base
<222>  (28)..(28)
<223>  GalNAc-conjugated
<220>  
<221>  modified_base
<222>  (29)..(29)
<223>  GalNAc-conjugated
<220>  
<221>  modified_base
<222>  (30)..(30)
<223>  GalNAc-conjugated
<220>  
<221>  modified_base
<222>  (31)..(31)
<223>  2'-O-methyl modified

<220>  
<221>  modified_base
<222>  (32)..(32)
<223>  2'-O-methyl modified

<220>  
<221>  modified_base
<222>  (33)..(33)
<223>  2'-O-methyl modified

<220>  
<221>  modified_base
<222>  (34)..(34)
<223>  2'-O-methyl modified

<220>  
<221>  modified_base
<222>  (35)..(35)
<223>  2'-O-methyl modified

<220>  
<221>  modified_base
<222>  (36)..(36)
<223>  2'-O-methyl modified

<400>  970
aguuauaacc gggaagacua gcagccgaaa ggcugc                                 36


<210>  971
<211>  36
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  Modified sense strand


<220>
<221>  misc_feature
<222>  (1)..(2)
<223>  linked via phosphorothioate

<220>  
<221>  modified_base
<222>  (1)..(1)
<223>  2'-O-methyl modified

<220>  
<221>  modified_base
<222>  (2)..(2)
<223>  2'-O-methyl modified

<220>  
<221>  modified_base
<222>  (3)..(3)
<223>  2'-O-methyl modified

<220>  
<221>  modified_base
<222>  (4)..(4)
<223>  2'-O-methyl modified

<220>  
<221>  modified_base
<222>  (5)..(5)
<223>  2'-O-methyl modified

<220>  
<221>  modified_base
<222>  (6)..(6)
<223>  2'-O-methyl modified

<220>  
<221>  modified_base
<222>  (7)..(7)
<223>  2'-O-methyl modified

<220>  
<221>  modified_base
<222>  (8)..(8)
<223>  2'-fluoro modified

<220>  
<221>  modified_base
<222>  (9)..(9)
<223>  2'-fluoro modified

<220>  
<221>  modified_base
<222>  (10)..(10)
<223>  2'-fluoro modified

<220>  
<221>  modified_base
<222>  (11)..(11)
<223>  2'-fluoro modified

<220>  
<221>  modified_base
<222>  (12)..(12)
<223>  2'-O-methyl modified

<220>  
<221>  modified_base
<222>  (13)..(13)
<223>  2'-O-methyl modified

<220>  
<221>  modified_base
<222>  (14)..(14)
<223>  2'-O-methyl modified

<220>  
<221>  modified_base
<222>  (15)..(15)
<223>  2'-O-methyl modified

<220>  
<221>  modified_base
<222>  (16)..(16)
<223>  2'-O-methyl modified

<220>  
<221>  modified_base
<222>  (17)..(17)
<223>  2'-O-methyl modified

<220>  
<221>  modified_base
<222>  (18)..(18)
<223>  2'-O-methyl modified

<220>  
<221>  modified_base
<222>  (19)..(19)
<223>  2'-O-methyl modified

<220>  
<221>  modified_base
<222>  (20)..(20)
<223>  2'-O-methyl modified

<220>  
<221>  modified_base
<222>  (21)..(21)
<223>  2'-O-methyl modified

<220>  
<221>  modified_base
<222>  (22)..(22)
<223>  2'-O-methyl modified

<220>  
<221>  modified_base
<222>  (23)..(23)
<223>  2'-O-methyl modified

<220>  
<221>  modified_base
<222>  (24)..(24)
<223>  2'-O-methyl modified

<220>  
<221>  modified_base
<222>  (25)..(25)
<223>  2'-O-methyl modified

<220>  
<221>  modified_base
<222>  (26)..(26)
<223>  2'-O-methyl modified

<220>  
<221>  modified_base
<222>  (27)..(27)
<223>  2'-O-methyl modified

<220>  
<221>  modified_base
<222>  (28)..(28)
<223>  GalNAc-conjugated
<220>  
<221>  modified_base
<222>  (29)..(29)
<223>  GalNAc-conjugated
<220>  
<221>  modified_base
<222>  (30)..(30)
<223>  GalNAc-conjugated
<220>  
<221>  modified_base
<222>  (31)..(31)
<223>  2'-O-methyl modified

<220>  
<221>  modified_base
<222>  (32)..(32)
<223>  2'-O-methyl modified

<220>  
<221>  modified_base
<222>  (33)..(33)
<223>  2'-O-methyl modified

<220>  
<221>  modified_base
<222>  (34)..(34)
<223>  2'-O-methyl modified

<220>  
<221>  modified_base
<222>  (35)..(35)
<223>  2'-O-methyl modified

<220>  
<221>  modified_base
<222>  (36)..(36)
<223>  2'-O-methyl modified

<400>  971
uauaaccggg aagacuuuga gcagccgaaa ggcugc                                 36


<210>  972
<211>  36
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  Modified sense strand


<220>
<221>  misc_feature
<222>  (1)..(2)
<223>  linked via phosphorothioate

<220>  
<221>  modified_base
<222>  (1)..(1)
<223>  2'-O-methyl modified

<220>  
<221>  modified_base
<222>  (2)..(2)
<223>  2'-O-methyl modified

<220>  
<221>  modified_base
<222>  (3)..(3)
<223>  2'-O-methyl modified

<220>  
<221>  modified_base
<222>  (4)..(4)
<223>  2'-O-methyl modified

<220>  
<221>  modified_base
<222>  (5)..(5)
<223>  2'-O-methyl modified

<220>  
<221>  modified_base
<222>  (6)..(6)
<223>  2'-O-methyl modified

<220>  
<221>  modified_base
<222>  (7)..(7)
<223>  2'-O-methyl modified

<220>  
<221>  modified_base
<222>  (8)..(8)
<223>  2'-fluoro modified

<220>  
<221>  modified_base
<222>  (9)..(9)
<223>  2'-fluoro modified

<220>  
<221>  modified_base
<222>  (10)..(10)
<223>  2'-fluoro modified

<220>  
<221>  modified_base
<222>  (11)..(11)
<223>  2'-fluoro modified

<220>  
<221>  modified_base
<222>  (12)..(12)
<223>  2'-O-methyl modified

<220>  
<221>  modified_base
<222>  (13)..(13)
<223>  2'-O-methyl modified

<220>  
<221>  modified_base
<222>  (14)..(14)
<223>  2'-O-methyl modified

<220>  
<221>  modified_base
<222>  (15)..(15)
<223>  2'-O-methyl modified

<220>  
<221>  modified_base
<222>  (16)..(16)
<223>  2'-O-methyl modified

<220>  
<221>  modified_base
<222>  (17)..(17)
<223>  2'-O-methyl modified

<220>  
<221>  modified_base
<222>  (18)..(18)
<223>  2'-O-methyl modified

<220>  
<221>  modified_base
<222>  (19)..(19)
<223>  2'-O-methyl modified

<220>  
<221>  modified_base
<222>  (20)..(20)
<223>  2'-O-methyl modified

<220>  
<221>  modified_base
<222>  (21)..(21)
<223>  2'-O-methyl modified

<220>  
<221>  modified_base
<222>  (22)..(22)
<223>  2'-O-methyl modified

<220>  
<221>  modified_base
<222>  (23)..(23)
<223>  2'-O-methyl modified

<220>  
<221>  modified_base
<222>  (24)..(24)
<223>  2'-O-methyl modified

<220>  
<221>  modified_base
<222>  (25)..(25)
<223>  2'-O-methyl modified

<220>  
<221>  modified_base
<222>  (26)..(26)
<223>  2'-O-methyl modified

<220>  
<221>  modified_base
<222>  (27)..(27)
<223>  2'-O-methyl modified

<220>  
<221>  modified_base
<222>  (28)..(28)
<223>  GalNAc-conjugated
<220>  
<221>  modified_base
<222>  (29)..(29)
<223>  GalNAc-conjugated
<220>  
<221>  modified_base
<222>  (30)..(30)
<223>  GalNAc-conjugated
<220>  
<221>  modified_base
<222>  (31)..(31)
<223>  2'-O-methyl modified

<220>  
<221>  modified_base
<222>  (32)..(32)
<223>  2'-O-methyl modified

<220>  
<221>  modified_base
<222>  (33)..(33)
<223>  2'-O-methyl modified

<220>  
<221>  modified_base
<222>  (34)..(34)
<223>  2'-O-methyl modified

<220>  
<221>  modified_base
<222>  (35)..(35)
<223>  2'-O-methyl modified

<220>  
<221>  modified_base
<222>  (36)..(36)
<223>  2'-O-methyl modified

<400>  972
caaagcaggg cugcaaguga gcagccgaaa ggcugc                                 36


<210>  973
<211>  36
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  Modified sense strand


<220>
<221>  misc_feature
<222>  (1)..(2)
<223>  linked via phosphorothioate

<220>  
<221>  modified_base
<222>  (1)..(1)
<223>  2'-O-methyl modified

<220>  
<221>  modified_base
<222>  (2)..(2)
<223>  2'-O-methyl modified

<220>  
<221>  modified_base
<222>  (3)..(3)
<223>  2'-O-methyl modified

<220>  
<221>  modified_base
<222>  (4)..(4)
<223>  2'-O-methyl modified

<220>  
<221>  modified_base
<222>  (5)..(5)
<223>  2'-O-methyl modified

<220>  
<221>  modified_base
<222>  (6)..(6)
<223>  2'-O-methyl modified

<220>  
<221>  modified_base
<222>  (7)..(7)
<223>  2'-O-methyl modified

<220>  
<221>  modified_base
<222>  (8)..(8)
<223>  2'-fluoro modified

<220>  
<221>  modified_base
<222>  (9)..(9)
<223>  2'-fluoro modified

<220>  
<221>  modified_base
<222>  (10)..(10)
<223>  2'-fluoro modified

<220>  
<221>  modified_base
<222>  (11)..(11)
<223>  2'-fluoro modified

<220>  
<221>  modified_base
<222>  (12)..(12)
<223>  2'-O-methyl modified

<220>  
<221>  modified_base
<222>  (13)..(13)
<223>  2'-O-methyl modified

<220>  
<221>  modified_base
<222>  (14)..(14)
<223>  2'-O-methyl modified

<220>  
<221>  modified_base
<222>  (15)..(15)
<223>  2'-O-methyl modified

<220>  
<221>  modified_base
<222>  (16)..(16)
<223>  2'-O-methyl modified

<220>  
<221>  modified_base
<222>  (17)..(17)
<223>  2'-O-methyl modified

<220>  
<221>  modified_base
<222>  (18)..(18)
<223>  2'-O-methyl modified

<220>  
<221>  modified_base
<222>  (19)..(19)
<223>  2'-O-methyl modified

<220>  
<221>  modified_base
<222>  (20)..(20)
<223>  2'-O-methyl modified

<220>  
<221>  modified_base
<222>  (21)..(21)
<223>  2'-O-methyl modified

<220>  
<221>  modified_base
<222>  (22)..(22)
<223>  2'-O-methyl modified

<220>  
<221>  modified_base
<222>  (23)..(23)
<223>  2'-O-methyl modified

<220>  
<221>  modified_base
<222>  (24)..(24)
<223>  2'-O-methyl modified

<220>  
<221>  modified_base
<222>  (25)..(25)
<223>  2'-O-methyl modified

<220>  
<221>  modified_base
<222>  (26)..(26)
<223>  2'-O-methyl modified

<220>  
<221>  modified_base
<222>  (27)..(27)
<223>  2'-O-methyl modified

<220>  
<221>  modified_base
<222>  (28)..(28)
<223>  GalNAc-conjugated
<220>  
<221>  modified_base
<222>  (29)..(29)
<223>  GalNAc-conjugated
<220>  
<221>  modified_base
<222>  (30)..(30)
<223>  GalNAc-conjugated
<220>  
<221>  modified_base
<222>  (31)..(31)
<223>  2'-O-methyl modified

<220>  
<221>  modified_base
<222>  (32)..(32)
<223>  2'-O-methyl modified

<220>  
<221>  modified_base
<222>  (33)..(33)
<223>  2'-O-methyl modified

<220>  
<221>  modified_base
<222>  (34)..(34)
<223>  2'-O-methyl modified

<220>  
<221>  modified_base
<222>  (35)..(35)
<223>  2'-O-methyl modified

<220>  
<221>  modified_base
<222>  (36)..(36)
<223>  2'-O-methyl modified

<400>  973
cagggcugca aguggaauua gcagccgaaa ggcugc                                 36


<210>  974
<211>  36
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  Modified sense strand


<220>
<221>  misc_feature
<222>  (1)..(2)
<223>  linked via phosphorothioate

<220>  
<221>  modified_base
<222>  (1)..(1)
<223>  2'-O-methyl modified

<220>  
<221>  modified_base
<222>  (2)..(2)
<223>  2'-O-methyl modified

<220>  
<221>  modified_base
<222>  (3)..(3)
<223>  2'-O-methyl modified

<220>  
<221>  modified_base
<222>  (4)..(4)
<223>  2'-O-methyl modified

<220>  
<221>  modified_base
<222>  (5)..(5)
<223>  2'-O-methyl modified

<220>  
<221>  modified_base
<222>  (6)..(6)
<223>  2'-O-methyl modified

<220>  
<221>  modified_base
<222>  (7)..(7)
<223>  2'-O-methyl modified

<220>  
<221>  modified_base
<222>  (8)..(8)
<223>  2'-fluoro modified

<220>  
<221>  modified_base
<222>  (9)..(9)
<223>  2'-fluoro modified

<220>  
<221>  modified_base
<222>  (10)..(10)
<223>  2'-fluoro modified

<220>  
<221>  modified_base
<222>  (11)..(11)
<223>  2'-fluoro modified

<220>  
<221>  modified_base
<222>  (12)..(12)
<223>  2'-O-methyl modified

<220>  
<221>  modified_base
<222>  (13)..(13)
<223>  2'-O-methyl modified

<220>  
<221>  modified_base
<222>  (14)..(14)
<223>  2'-O-methyl modified

<220>  
<221>  modified_base
<222>  (15)..(15)
<223>  2'-O-methyl modified

<220>  
<221>  modified_base
<222>  (16)..(16)
<223>  2'-O-methyl modified

<220>  
<221>  modified_base
<222>  (17)..(17)
<223>  2'-O-methyl modified

<220>  
<221>  modified_base
<222>  (18)..(18)
<223>  2'-O-methyl modified

<220>  
<221>  modified_base
<222>  (19)..(19)
<223>  2'-O-methyl modified

<220>  
<221>  modified_base
<222>  (20)..(20)
<223>  2'-O-methyl modified

<220>  
<221>  modified_base
<222>  (21)..(21)
<223>  2'-O-methyl modified

<220>  
<221>  modified_base
<222>  (22)..(22)
<223>  2'-O-methyl modified

<220>  
<221>  modified_base
<222>  (23)..(23)
<223>  2'-O-methyl modified

<220>  
<221>  modified_base
<222>  (24)..(24)
<223>  2'-O-methyl modified

<220>  
<221>  modified_base
<222>  (25)..(25)
<223>  2'-O-methyl modified

<220>  
<221>  modified_base
<222>  (26)..(26)
<223>  2'-O-methyl modified

<220>  
<221>  modified_base
<222>  (27)..(27)
<223>  2'-O-methyl modified

<220>  
<221>  modified_base
<222>  (28)..(28)
<223>  GalNAc-conjugated
<220>  
<221>  modified_base
<222>  (29)..(29)
<223>  GalNAc-conjugated
<220>  
<221>  modified_base
<222>  (30)..(30)
<223>  GalNAc-conjugated
<220>  
<221>  modified_base
<222>  (31)..(31)
<223>  2'-O-methyl modified

<220>  
<221>  modified_base
<222>  (32)..(32)
<223>  2'-O-methyl modified

<220>  
<221>  modified_base
<222>  (33)..(33)
<223>  2'-O-methyl modified

<220>  
<221>  modified_base
<222>  (34)..(34)
<223>  2'-O-methyl modified

<220>  
<221>  modified_base
<222>  (35)..(35)
<223>  2'-O-methyl modified

<220>  
<221>  modified_base
<222>  (36)..(36)
<223>  2'-O-methyl modified

<400>  974
ggcugcaagu ggaauucaua gcagccgaaa ggcugc                                 36


<210>  975
<211>  36
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  Modified sense strand


<220>
<221>  misc_feature
<222>  (1)..(2)
<223>  linked via phosphorothioate

<220>  
<221>  modified_base
<222>  (1)..(1)
<223>  2'-O-methyl modified

<220>  
<221>  modified_base
<222>  (2)..(2)
<223>  2'-O-methyl modified

<220>  
<221>  modified_base
<222>  (3)..(3)
<223>  2'-O-methyl modified

<220>  
<221>  modified_base
<222>  (4)..(4)
<223>  2'-O-methyl modified

<220>  
<221>  modified_base
<222>  (5)..(5)
<223>  2'-O-methyl modified

<220>  
<221>  modified_base
<222>  (6)..(6)
<223>  2'-O-methyl modified

<220>  
<221>  modified_base
<222>  (7)..(7)
<223>  2'-O-methyl modified

<220>  
<221>  modified_base
<222>  (8)..(8)
<223>  2'-fluoro modified

<220>  
<221>  modified_base
<222>  (9)..(9)
<223>  2'-fluoro modified

<220>  
<221>  modified_base
<222>  (10)..(10)
<223>  2'-fluoro modified

<220>  
<221>  modified_base
<222>  (11)..(11)
<223>  2'-fluoro modified

<220>  
<221>  modified_base
<222>  (12)..(12)
<223>  2'-O-methyl modified

<220>  
<221>  modified_base
<222>  (13)..(13)
<223>  2'-O-methyl modified

<220>  
<221>  modified_base
<222>  (14)..(14)
<223>  2'-O-methyl modified

<220>  
<221>  modified_base
<222>  (15)..(15)
<223>  2'-O-methyl modified

<220>  
<221>  modified_base
<222>  (16)..(16)
<223>  2'-O-methyl modified

<220>  
<221>  modified_base
<222>  (17)..(17)
<223>  2'-O-methyl modified

<220>  
<221>  modified_base
<222>  (18)..(18)
<223>  2'-O-methyl modified

<220>  
<221>  modified_base
<222>  (19)..(19)
<223>  2'-O-methyl modified

<220>  
<221>  modified_base
<222>  (20)..(20)
<223>  2'-O-methyl modified

<220>  
<221>  modified_base
<222>  (21)..(21)
<223>  2'-O-methyl modified

<220>  
<221>  modified_base
<222>  (22)..(22)
<223>  2'-O-methyl modified

<220>  
<221>  modified_base
<222>  (23)..(23)
<223>  2'-O-methyl modified

<220>  
<221>  modified_base
<222>  (24)..(24)
<223>  2'-O-methyl modified

<220>  
<221>  modified_base
<222>  (25)..(25)
<223>  2'-O-methyl modified

<220>  
<221>  modified_base
<222>  (26)..(26)
<223>  2'-O-methyl modified

<220>  
<221>  modified_base
<222>  (27)..(27)
<223>  2'-O-methyl modified

<220>  
<221>  modified_base
<222>  (28)..(28)
<223>  GalNAc-conjugated
<220>  
<221>  modified_base
<222>  (29)..(29)
<223>  GalNAc-conjugated
<220>  
<221>  modified_base
<222>  (30)..(30)
<223>  GalNAc-conjugated
<220>  
<221>  modified_base
<222>  (31)..(31)
<223>  2'-O-methyl modified

<220>  
<221>  modified_base
<222>  (32)..(32)
<223>  2'-O-methyl modified

<220>  
<221>  modified_base
<222>  (33)..(33)
<223>  2'-O-methyl modified

<220>  
<221>  modified_base
<222>  (34)..(34)
<223>  2'-O-methyl modified

<220>  
<221>  modified_base
<222>  (35)..(35)
<223>  2'-O-methyl modified

<220>  
<221>  modified_base
<222>  (36)..(36)
<223>  2'-O-methyl modified

<400>  975
cugcaagugg aauucaucaa gcagccgaaa ggcugc                                 36


<210>  976
<211>  36
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  Modified sense strand


<220>
<221>  misc_feature
<222>  (1)..(2)
<223>  linked via phosphorothioate

<220>  
<221>  modified_base
<222>  (1)..(1)
<223>  2'-O-methyl modified

<220>  
<221>  modified_base
<222>  (2)..(2)
<223>  2'-O-methyl modified

<220>  
<221>  modified_base
<222>  (3)..(3)
<223>  2'-O-methyl modified

<220>  
<221>  modified_base
<222>  (4)..(4)
<223>  2'-O-methyl modified

<220>  
<221>  modified_base
<222>  (5)..(5)
<223>  2'-O-methyl modified

<220>  
<221>  modified_base
<222>  (6)..(6)
<223>  2'-O-methyl modified

<220>  
<221>  modified_base
<222>  (7)..(7)
<223>  2'-O-methyl modified

<220>  
<221>  modified_base
<222>  (8)..(8)
<223>  2'-fluoro modified

<220>  
<221>  modified_base
<222>  (9)..(9)
<223>  2'-fluoro modified

<220>  
<221>  modified_base
<222>  (10)..(10)
<223>  2'-fluoro modified

<220>  
<221>  modified_base
<222>  (11)..(11)
<223>  2'-fluoro modified

<220>  
<221>  modified_base
<222>  (12)..(12)
<223>  2'-O-methyl modified

<220>  
<221>  modified_base
<222>  (13)..(13)
<223>  2'-O-methyl modified

<220>  
<221>  modified_base
<222>  (14)..(14)
<223>  2'-O-methyl modified

<220>  
<221>  modified_base
<222>  (15)..(15)
<223>  2'-O-methyl modified

<220>  
<221>  modified_base
<222>  (16)..(16)
<223>  2'-O-methyl modified

<220>  
<221>  modified_base
<222>  (17)..(17)
<223>  2'-O-methyl modified

<220>  
<221>  modified_base
<222>  (18)..(18)
<223>  2'-O-methyl modified

<220>  
<221>  modified_base
<222>  (19)..(19)
<223>  2'-O-methyl modified

<220>  
<221>  modified_base
<222>  (20)..(20)
<223>  2'-O-methyl modified

<220>  
<221>  modified_base
<222>  (21)..(21)
<223>  2'-O-methyl modified

<220>  
<221>  modified_base
<222>  (22)..(22)
<223>  2'-O-methyl modified

<220>  
<221>  modified_base
<222>  (23)..(23)
<223>  2'-O-methyl modified

<220>  
<221>  modified_base
<222>  (24)..(24)
<223>  2'-O-methyl modified

<220>  
<221>  modified_base
<222>  (25)..(25)
<223>  2'-O-methyl modified

<220>  
<221>  modified_base
<222>  (26)..(26)
<223>  2'-O-methyl modified

<220>  
<221>  modified_base
<222>  (27)..(27)
<223>  2'-O-methyl modified

<220>  
<221>  modified_base
<222>  (28)..(28)
<223>  GalNAc-conjugated
<220>  
<221>  modified_base
<222>  (29)..(29)
<223>  GalNAc-conjugated
<220>  
<221>  modified_base
<222>  (30)..(30)
<223>  GalNAc-conjugated
<220>  
<221>  modified_base
<222>  (31)..(31)
<223>  2'-O-methyl modified

<220>  
<221>  modified_base
<222>  (32)..(32)
<223>  2'-O-methyl modified

<220>  
<221>  modified_base
<222>  (33)..(33)
<223>  2'-O-methyl modified

<220>  
<221>  modified_base
<222>  (34)..(34)
<223>  2'-O-methyl modified

<220>  
<221>  modified_base
<222>  (35)..(35)
<223>  2'-O-methyl modified

<220>  
<221>  modified_base
<222>  (36)..(36)
<223>  2'-O-methyl modified

<400>  976
ugcaagugga auucaucaaa gcagccgaaa ggcugc                                 36


<210>  977
<211>  36
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  Modified sense strand


<220>
<221>  misc_feature
<222>  (1)..(2)
<223>  linked via phosphorothioate

<220>  
<221>  modified_base
<222>  (1)..(1)
<223>  2'-O-methyl modified

<220>  
<221>  modified_base
<222>  (2)..(2)
<223>  2'-O-methyl modified

<220>  
<221>  modified_base
<222>  (3)..(3)
<223>  2'-O-methyl modified

<220>  
<221>  modified_base
<222>  (4)..(4)
<223>  2'-O-methyl modified

<220>  
<221>  modified_base
<222>  (5)..(5)
<223>  2'-O-methyl modified

<220>  
<221>  modified_base
<222>  (6)..(6)
<223>  2'-O-methyl modified

<220>  
<221>  modified_base
<222>  (7)..(7)
<223>  2'-O-methyl modified

<220>  
<221>  modified_base
<222>  (8)..(8)
<223>  2'-fluoro modified

<220>  
<221>  modified_base
<222>  (9)..(9)
<223>  2'-fluoro modified

<220>  
<221>  modified_base
<222>  (10)..(10)
<223>  2'-fluoro modified

<220>  
<221>  modified_base
<222>  (11)..(11)
<223>  2'-fluoro modified

<220>  
<221>  modified_base
<222>  (12)..(12)
<223>  2'-O-methyl modified

<220>  
<221>  modified_base
<222>  (13)..(13)
<223>  2'-O-methyl modified

<220>  
<221>  modified_base
<222>  (14)..(14)
<223>  2'-O-methyl modified

<220>  
<221>  modified_base
<222>  (15)..(15)
<223>  2'-O-methyl modified

<220>  
<221>  modified_base
<222>  (16)..(16)
<223>  2'-O-methyl modified

<220>  
<221>  modified_base
<222>  (17)..(17)
<223>  2'-O-methyl modified

<220>  
<221>  modified_base
<222>  (18)..(18)
<223>  2'-O-methyl modified

<220>  
<221>  modified_base
<222>  (19)..(19)
<223>  2'-O-methyl modified

<220>  
<221>  modified_base
<222>  (20)..(20)
<223>  2'-O-methyl modified

<220>  
<221>  modified_base
<222>  (21)..(21)
<223>  2'-O-methyl modified

<220>  
<221>  modified_base
<222>  (22)..(22)
<223>  2'-O-methyl modified

<220>  
<221>  modified_base
<222>  (23)..(23)
<223>  2'-O-methyl modified

<220>  
<221>  modified_base
<222>  (24)..(24)
<223>  2'-O-methyl modified

<220>  
<221>  modified_base
<222>  (25)..(25)
<223>  2'-O-methyl modified

<220>  
<221>  modified_base
<222>  (26)..(26)
<223>  2'-O-methyl modified

<220>  
<221>  modified_base
<222>  (27)..(27)
<223>  2'-O-methyl modified

<220>  
<221>  modified_base
<222>  (28)..(28)
<223>  GalNAc-conjugated
<220>  
<221>  modified_base
<222>  (29)..(29)
<223>  GalNAc-conjugated
<220>  
<221>  modified_base
<222>  (30)..(30)
<223>  GalNAc-conjugated
<220>  
<221>  modified_base
<222>  (31)..(31)
<223>  2'-O-methyl modified

<220>  
<221>  modified_base
<222>  (32)..(32)
<223>  2'-O-methyl modified

<220>  
<221>  modified_base
<222>  (33)..(33)
<223>  2'-O-methyl modified

<220>  
<221>  modified_base
<222>  (34)..(34)
<223>  2'-O-methyl modified

<220>  
<221>  modified_base
<222>  (35)..(35)
<223>  2'-O-methyl modified

<220>  
<221>  modified_base
<222>  (36)..(36)
<223>  2'-O-methyl modified

<400>  977
gcaaguggaa uucaucaaca gcagccgaaa ggcugc                                 36


<210>  978
<211>  36
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  Modified sense strand


<220>
<221>  misc_feature
<222>  (1)..(2)
<223>  linked via phosphorothioate

<220>  
<221>  modified_base
<222>  (1)..(1)
<223>  2'-O-methyl modified

<220>  
<221>  modified_base
<222>  (2)..(2)
<223>  2'-O-methyl modified

<220>  
<221>  modified_base
<222>  (3)..(3)
<223>  2'-O-methyl modified

<220>  
<221>  modified_base
<222>  (4)..(4)
<223>  2'-O-methyl modified

<220>  
<221>  modified_base
<222>  (5)..(5)
<223>  2'-O-methyl modified

<220>  
<221>  modified_base
<222>  (6)..(6)
<223>  2'-O-methyl modified

<220>  
<221>  modified_base
<222>  (7)..(7)
<223>  2'-O-methyl modified

<220>  
<221>  modified_base
<222>  (8)..(8)
<223>  2'-fluoro modified

<220>  
<221>  modified_base
<222>  (9)..(9)
<223>  2'-fluoro modified

<220>  
<221>  modified_base
<222>  (10)..(10)
<223>  2'-fluoro modified

<220>  
<221>  modified_base
<222>  (11)..(11)
<223>  2'-fluoro modified

<220>  
<221>  modified_base
<222>  (12)..(12)
<223>  2'-O-methyl modified

<220>  
<221>  modified_base
<222>  (13)..(13)
<223>  2'-O-methyl modified

<220>  
<221>  modified_base
<222>  (14)..(14)
<223>  2'-O-methyl modified

<220>  
<221>  modified_base
<222>  (15)..(15)
<223>  2'-O-methyl modified

<220>  
<221>  modified_base
<222>  (16)..(16)
<223>  2'-O-methyl modified

<220>  
<221>  modified_base
<222>  (17)..(17)
<223>  2'-O-methyl modified

<220>  
<221>  modified_base
<222>  (18)..(18)
<223>  2'-O-methyl modified

<220>  
<221>  modified_base
<222>  (19)..(19)
<223>  2'-O-methyl modified

<220>  
<221>  modified_base
<222>  (20)..(20)
<223>  2'-O-methyl modified

<220>  
<221>  modified_base
<222>  (21)..(21)
<223>  2'-O-methyl modified

<220>  
<221>  modified_base
<222>  (22)..(22)
<223>  2'-O-methyl modified

<220>  
<221>  modified_base
<222>  (23)..(23)
<223>  2'-O-methyl modified

<220>  
<221>  modified_base
<222>  (24)..(24)
<223>  2'-O-methyl modified

<220>  
<221>  modified_base
<222>  (25)..(25)
<223>  2'-O-methyl modified

<220>  
<221>  modified_base
<222>  (26)..(26)
<223>  2'-O-methyl modified

<220>  
<221>  modified_base
<222>  (27)..(27)
<223>  2'-O-methyl modified

<220>  
<221>  modified_base
<222>  (28)..(28)
<223>  GalNAc-conjugated
<220>  
<221>  modified_base
<222>  (29)..(29)
<223>  GalNAc-conjugated
<220>  
<221>  modified_base
<222>  (30)..(30)
<223>  GalNAc-conjugated
<220>  
<221>  modified_base
<222>  (31)..(31)
<223>  2'-O-methyl modified

<220>  
<221>  modified_base
<222>  (32)..(32)
<223>  2'-O-methyl modified

<220>  
<221>  modified_base
<222>  (33)..(33)
<223>  2'-O-methyl modified

<220>  
<221>  modified_base
<222>  (34)..(34)
<223>  2'-O-methyl modified

<220>  
<221>  modified_base
<222>  (35)..(35)
<223>  2'-O-methyl modified

<220>  
<221>  modified_base
<222>  (36)..(36)
<223>  2'-O-methyl modified

<400>  978
caaguggaau ucaucaacca gcagccgaaa ggcugc                                 36


<210>  979
<211>  36
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  Modified sense strand


<220>
<221>  misc_feature
<222>  (1)..(2)
<223>  linked via phosphorothioate

<220>  
<221>  modified_base
<222>  (1)..(1)
<223>  2'-O-methyl modified

<220>  
<221>  modified_base
<222>  (2)..(2)
<223>  2'-O-methyl modified

<220>  
<221>  modified_base
<222>  (3)..(3)
<223>  2'-O-methyl modified

<220>  
<221>  modified_base
<222>  (4)..(4)
<223>  2'-O-methyl modified

<220>  
<221>  modified_base
<222>  (5)..(5)
<223>  2'-O-methyl modified

<220>  
<221>  modified_base
<222>  (6)..(6)
<223>  2'-O-methyl modified

<220>  
<221>  modified_base
<222>  (7)..(7)
<223>  2'-O-methyl modified

<220>  
<221>  modified_base
<222>  (8)..(8)
<223>  2'-fluoro modified

<220>  
<221>  modified_base
<222>  (9)..(9)
<223>  2'-fluoro modified

<220>  
<221>  modified_base
<222>  (10)..(10)
<223>  2'-fluoro modified

<220>  
<221>  modified_base
<222>  (11)..(11)
<223>  2'-fluoro modified

<220>  
<221>  modified_base
<222>  (12)..(12)
<223>  2'-O-methyl modified

<220>  
<221>  modified_base
<222>  (13)..(13)
<223>  2'-O-methyl modified

<220>  
<221>  modified_base
<222>  (14)..(14)
<223>  2'-O-methyl modified

<220>  
<221>  modified_base
<222>  (15)..(15)
<223>  2'-O-methyl modified

<220>  
<221>  modified_base
<222>  (16)..(16)
<223>  2'-O-methyl modified

<220>  
<221>  modified_base
<222>  (17)..(17)
<223>  2'-O-methyl modified

<220>  
<221>  modified_base
<222>  (18)..(18)
<223>  2'-O-methyl modified

<220>  
<221>  modified_base
<222>  (19)..(19)
<223>  2'-O-methyl modified

<220>  
<221>  modified_base
<222>  (20)..(20)
<223>  2'-O-methyl modified

<220>  
<221>  modified_base
<222>  (21)..(21)
<223>  2'-O-methyl modified

<220>  
<221>  modified_base
<222>  (22)..(22)
<223>  2'-O-methyl modified

<220>  
<221>  modified_base
<222>  (23)..(23)
<223>  2'-O-methyl modified

<220>  
<221>  modified_base
<222>  (24)..(24)
<223>  2'-O-methyl modified

<220>  
<221>  modified_base
<222>  (25)..(25)
<223>  2'-O-methyl modified

<220>  
<221>  modified_base
<222>  (26)..(26)
<223>  2'-O-methyl modified

<220>  
<221>  modified_base
<222>  (27)..(27)
<223>  2'-O-methyl modified

<220>  
<221>  modified_base
<222>  (28)..(28)
<223>  GalNAc-conjugated

<220>  
<221>  modified_base
<222>  (29)..(29)
<223>  GalNAc-conjugated

<220>  
<221>  modified_base
<222>  (30)..(30)
<223>  GalNAc-conjugated

<220>  
<221>  modified_base
<222>  (31)..(31)
<223>  2'-O-methyl modified

<220>  
<221>  modified_base
<222>  (32)..(32)
<223>  2'-O-methyl modified

<220>  
<221>  modified_base
<222>  (33)..(33)
<223>  2'-O-methyl modified

<220>  
<221>  modified_base
<222>  (34)..(34)
<223>  2'-O-methyl modified

<220>  
<221>  modified_base
<222>  (35)..(35)
<223>  2'-O-methyl modified

<220>  
<221>  modified_base
<222>  (36)..(36)
<223>  2'-O-methyl modified

<400>  979
aguggaauuc aucaacccca gcagccgaaa ggcugc                                 36


<210>  980
<211>  36
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  Modified sense strand


<220>
<221>  misc_feature
<222>  (1)..(2)
<223>  linked via phosphorothioate

<220>  
<221>  modified_base
<222>  (1)..(1)
<223>  2'-O-methyl modified

<220>  
<221>  modified_base
<222>  (2)..(2)
<223>  2'-O-methyl modified

<220>  
<221>  modified_base
<222>  (3)..(3)
<223>  2'-O-methyl modified

<220>  
<221>  modified_base
<222>  (4)..(4)
<223>  2'-O-methyl modified

<220>  
<221>  modified_base
<222>  (5)..(5)
<223>  2'-O-methyl modified

<220>  
<221>  modified_base
<222>  (6)..(6)
<223>  2'-O-methyl modified

<220>  
<221>  modified_base
<222>  (7)..(7)
<223>  2'-O-methyl modified

<220>  
<221>  modified_base
<222>  (8)..(8)
<223>  2'-fluoro modified

<220>  
<221>  modified_base
<222>  (9)..(9)
<223>  2'-fluoro modified

<220>  
<221>  modified_base
<222>  (10)..(10)
<223>  2'-fluoro modified

<220>  
<221>  modified_base
<222>  (11)..(11)
<223>  2'-fluoro modified

<220>  
<221>  modified_base
<222>  (12)..(12)
<223>  2'-O-methyl modified

<220>  
<221>  modified_base
<222>  (13)..(13)
<223>  2'-O-methyl modified

<220>  
<221>  modified_base
<222>  (14)..(14)
<223>  2'-O-methyl modified

<220>  
<221>  modified_base
<222>  (15)..(15)
<223>  2'-O-methyl modified

<220>  
<221>  modified_base
<222>  (16)..(16)
<223>  2'-O-methyl modified

<220>  
<221>  modified_base
<222>  (17)..(17)
<223>  2'-O-methyl modified

<220>  
<221>  modified_base
<222>  (18)..(18)
<223>  2'-O-methyl modified

<220>  
<221>  modified_base
<222>  (19)..(19)
<223>  2'-O-methyl modified

<220>  
<221>  modified_base
<222>  (20)..(20)
<223>  2'-O-methyl modified

<220>  
<221>  modified_base
<222>  (21)..(21)
<223>  2'-O-methyl modified

<220>  
<221>  modified_base
<222>  (22)..(22)
<223>  2'-O-methyl modified

<220>  
<221>  modified_base
<222>  (23)..(23)
<223>  2'-O-methyl modified

<220>  
<221>  modified_base
<222>  (24)..(24)
<223>  2'-O-methyl modified

<220>  
<221>  modified_base
<222>  (25)..(25)
<223>  2'-O-methyl modified

<220>  
<221>  modified_base
<222>  (26)..(26)
<223>  2'-O-methyl modified

<220>  
<221>  modified_base
<222>  (27)..(27)
<223>  2'-O-methyl modified

<220>  
<221>  modified_base
<222>  (28)..(28)
<223>  GalNAc-conjugated

<220>  
<221>  modified_base
<222>  (29)..(29)
<223>  GalNAc-conjugated

<220>  
<221>  modified_base
<222>  (30)..(30)
<223>  GalNAc-conjugated

<220>  
<221>  modified_base
<222>  (31)..(31)
<223>  2'-O-methyl modified

<220>  
<221>  modified_base
<222>  (32)..(32)
<223>  2'-O-methyl modified

<220>  
<221>  modified_base
<222>  (33)..(33)
<223>  2'-O-methyl modified

<220>  
<221>  modified_base
<222>  (34)..(34)
<223>  2'-O-methyl modified

<220>  
<221>  modified_base
<222>  (35)..(35)
<223>  2'-O-methyl modified

<220>  
<221>  modified_base
<222>  (36)..(36)
<223>  2'-O-methyl modified

<400>  980
guggaauuca ucaaccccaa gcagccgaaa ggcugc                                 36


<210>  981
<211>  36
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  Modified sense strand


<220>
<221>  misc_feature
<222>  (1)..(2)
<223>  linked via phosphorothioate

<220>  
<221>  modified_base
<222>  (1)..(1)
<223>  2'-O-methyl modified

<220>  
<221>  modified_base
<222>  (2)..(2)
<223>  2'-O-methyl modified

<220>  
<221>  modified_base
<222>  (3)..(3)
<223>  2'-O-methyl modified

<220>  
<221>  modified_base
<222>  (4)..(4)
<223>  2'-O-methyl modified

<220>  
<221>  modified_base
<222>  (5)..(5)
<223>  2'-O-methyl modified

<220>  
<221>  modified_base
<222>  (6)..(6)
<223>  2'-O-methyl modified

<220>  
<221>  modified_base
<222>  (7)..(7)
<223>  2'-O-methyl modified

<220>  
<221>  modified_base
<222>  (8)..(8)
<223>  2'-fluoro modified

<220>  
<221>  modified_base
<222>  (9)..(9)
<223>  2'-fluoro modified

<220>  
<221>  modified_base
<222>  (10)..(10)
<223>  2'-fluoro modified

<220>  
<221>  modified_base
<222>  (11)..(11)
<223>  2'-fluoro modified

<220>  
<221>  modified_base
<222>  (12)..(12)
<223>  2'-O-methyl modified

<220>  
<221>  modified_base
<222>  (13)..(13)
<223>  2'-O-methyl modified

<220>  
<221>  modified_base
<222>  (14)..(14)
<223>  2'-O-methyl modified

<220>  
<221>  modified_base
<222>  (15)..(15)
<223>  2'-O-methyl modified

<220>  
<221>  modified_base
<222>  (16)..(16)
<223>  2'-O-methyl modified

<220>  
<221>  modified_base
<222>  (17)..(17)
<223>  2'-O-methyl modified

<220>  
<221>  modified_base
<222>  (18)..(18)
<223>  2'-O-methyl modified

<220>  
<221>  modified_base
<222>  (19)..(19)
<223>  2'-O-methyl modified

<220>  
<221>  modified_base
<222>  (20)..(20)
<223>  2'-O-methyl modified

<220>  
<221>  modified_base
<222>  (21)..(21)
<223>  2'-O-methyl modified

<220>  
<221>  modified_base
<222>  (22)..(22)
<223>  2'-O-methyl modified

<220>  
<221>  modified_base
<222>  (23)..(23)
<223>  2'-O-methyl modified

<220>  
<221>  modified_base
<222>  (24)..(24)
<223>  2'-O-methyl modified

<220>  
<221>  modified_base
<222>  (25)..(25)
<223>  2'-O-methyl modified

<220>  
<221>  modified_base
<222>  (26)..(26)
<223>  2'-O-methyl modified

<220>  
<221>  modified_base
<222>  (27)..(27)
<223>  2'-O-methyl modified

<220>  
<221>  modified_base
<222>  (28)..(28)
<223>  GalNAc-conjugated

<220>  
<221>  modified_base
<222>  (29)..(29)
<223>  GalNAc-conjugated

<220>  
<221>  modified_base
<222>  (30)..(30)
<223>  GalNAc-conjugated

<220>  
<221>  modified_base
<222>  (31)..(31)
<223>  2'-O-methyl modified

<220>  
<221>  modified_base
<222>  (32)..(32)
<223>  2'-O-methyl modified

<220>  
<221>  modified_base
<222>  (33)..(33)
<223>  2'-O-methyl modified

<220>  
<221>  modified_base
<222>  (34)..(34)
<223>  2'-O-methyl modified

<220>  
<221>  modified_base
<222>  (35)..(35)
<223>  2'-O-methyl modified

<220>  
<221>  modified_base
<222>  (36)..(36)
<223>  2'-O-methyl modified

<400>  981
uggaauucau caaccccaua gcagccgaaa ggcugc                                 36


<210>  982
<211>  36
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  Modified sense strand


<220>
<221>  misc_feature
<222>  (1)..(2)
<223>  linked via phosphorothioate

<220>  
<221>  modified_base
<222>  (1)..(1)
<223>  2'-O-methyl modified

<220>  
<221>  modified_base
<222>  (2)..(2)
<223>  2'-O-methyl modified

<220>  
<221>  modified_base
<222>  (3)..(3)
<223>  2'-O-methyl modified

<220>  
<221>  modified_base
<222>  (4)..(4)
<223>  2'-O-methyl modified

<220>  
<221>  modified_base
<222>  (5)..(5)
<223>  2'-O-methyl modified

<220>  
<221>  modified_base
<222>  (6)..(6)
<223>  2'-O-methyl modified

<220>  
<221>  modified_base
<222>  (7)..(7)
<223>  2'-O-methyl modified

<220>  
<221>  modified_base
<222>  (8)..(8)
<223>  2'-fluoro modified

<220>  
<221>  modified_base
<222>  (9)..(9)
<223>  2'-fluoro modified

<220>  
<221>  modified_base
<222>  (10)..(10)
<223>  2'-fluoro modified

<220>  
<221>  modified_base
<222>  (11)..(11)
<223>  2'-fluoro modified

<220>  
<221>  modified_base
<222>  (12)..(12)
<223>  2'-O-methyl modified

<220>  
<221>  modified_base
<222>  (13)..(13)
<223>  2'-O-methyl modified

<220>  
<221>  modified_base
<222>  (14)..(14)
<223>  2'-O-methyl modified

<220>  
<221>  modified_base
<222>  (15)..(15)
<223>  2'-O-methyl modified

<220>  
<221>  modified_base
<222>  (16)..(16)
<223>  2'-O-methyl modified

<220>  
<221>  modified_base
<222>  (17)..(17)
<223>  2'-O-methyl modified

<220>  
<221>  modified_base
<222>  (18)..(18)
<223>  2'-O-methyl modified

<220>  
<221>  modified_base
<222>  (19)..(19)
<223>  2'-O-methyl modified

<220>  
<221>  modified_base
<222>  (20)..(20)
<223>  2'-O-methyl modified

<220>  
<221>  modified_base
<222>  (21)..(21)
<223>  2'-O-methyl modified

<220>  
<221>  modified_base
<222>  (22)..(22)
<223>  2'-O-methyl modified

<220>  
<221>  modified_base
<222>  (23)..(23)
<223>  2'-O-methyl modified

<220>  
<221>  modified_base
<222>  (24)..(24)
<223>  2'-O-methyl modified

<220>  
<221>  modified_base
<222>  (25)..(25)
<223>  2'-O-methyl modified

<220>  
<221>  modified_base
<222>  (26)..(26)
<223>  2'-O-methyl modified

<220>  
<221>  modified_base
<222>  (27)..(27)
<223>  2'-O-methyl modified

<220>  
<221>  modified_base
<222>  (28)..(28)
<223>  GalNAc-conjugated

<220>  
<221>  modified_base
<222>  (29)..(29)
<223>  GalNAc-conjugated

<220>  
<221>  modified_base
<222>  (30)..(30)
<223>  GalNAc-conjugated

<220>  
<221>  modified_base
<222>  (31)..(31)
<223>  2'-O-methyl modified

<220>  
<221>  modified_base
<222>  (32)..(32)
<223>  2'-O-methyl modified

<220>  
<221>  modified_base
<222>  (33)..(33)
<223>  2'-O-methyl modified

<220>  
<221>  modified_base
<222>  (34)..(34)
<223>  2'-O-methyl modified

<220>  
<221>  modified_base
<222>  (35)..(35)
<223>  2'-O-methyl modified

<220>  
<221>  modified_base
<222>  (36)..(36)
<223>  2'-O-methyl modified

<400>  982
gaauucauca accccaucua gcagccgaaa ggcugc                                 36


<210>  983
<211>  36
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  Modified sense strand


<220>
<221>  misc_feature
<222>  (1)..(2)
<223>  linked via phosphorothioate

<220>  
<221>  modified_base
<222>  (1)..(1)
<223>  2'-O-methyl modified

<220>  
<221>  modified_base
<222>  (2)..(2)
<223>  2'-O-methyl modified

<220>  
<221>  modified_base
<222>  (3)..(3)
<223>  2'-O-methyl modified

<220>  
<221>  modified_base
<222>  (4)..(4)
<223>  2'-O-methyl modified

<220>  
<221>  modified_base
<222>  (5)..(5)
<223>  2'-O-methyl modified

<220>  
<221>  modified_base
<222>  (6)..(6)
<223>  2'-O-methyl modified

<220>  
<221>  modified_base
<222>  (7)..(7)
<223>  2'-O-methyl modified

<220>  
<221>  modified_base
<222>  (8)..(8)
<223>  2'-fluoro modified

<220>  
<221>  modified_base
<222>  (9)..(9)
<223>  2'-fluoro modified

<220>  
<221>  modified_base
<222>  (10)..(10)
<223>  2'-fluoro modified

<220>  
<221>  modified_base
<222>  (11)..(11)
<223>  2'-fluoro modified

<220>  
<221>  modified_base
<222>  (12)..(12)
<223>  2'-O-methyl modified

<220>  
<221>  modified_base
<222>  (13)..(13)
<223>  2'-O-methyl modified

<220>  
<221>  modified_base
<222>  (14)..(14)
<223>  2'-O-methyl modified

<220>  
<221>  modified_base
<222>  (15)..(15)
<223>  2'-O-methyl modified

<220>  
<221>  modified_base
<222>  (16)..(16)
<223>  2'-O-methyl modified

<220>  
<221>  modified_base
<222>  (17)..(17)
<223>  2'-O-methyl modified

<220>  
<221>  modified_base
<222>  (18)..(18)
<223>  2'-O-methyl modified

<220>  
<221>  modified_base
<222>  (19)..(19)
<223>  2'-O-methyl modified

<220>  
<221>  modified_base
<222>  (20)..(20)
<223>  2'-O-methyl modified

<220>  
<221>  modified_base
<222>  (21)..(21)
<223>  2'-O-methyl modified

<220>  
<221>  modified_base
<222>  (22)..(22)
<223>  2'-O-methyl modified

<220>  
<221>  modified_base
<222>  (23)..(23)
<223>  2'-O-methyl modified

<220>  
<221>  modified_base
<222>  (24)..(24)
<223>  2'-O-methyl modified

<220>  
<221>  modified_base
<222>  (25)..(25)
<223>  2'-O-methyl modified

<220>  
<221>  modified_base
<222>  (26)..(26)
<223>  2'-O-methyl modified

<220>  
<221>  modified_base
<222>  (27)..(27)
<223>  2'-O-methyl modified

<220>  
<221>  modified_base
<222>  (28)..(28)
<223>  GalNAc-conjugated

<220>  
<221>  modified_base
<222>  (29)..(29)
<223>  GalNAc-conjugated

<220>  
<221>  modified_base
<222>  (30)..(30)
<223>  GalNAc-conjugated

<220>  
<221>  modified_base
<222>  (31)..(31)
<223>  2'-O-methyl modified

<220>  
<221>  modified_base
<222>  (32)..(32)
<223>  2'-O-methyl modified

<220>  
<221>  modified_base
<222>  (33)..(33)
<223>  2'-O-methyl modified

<220>  
<221>  modified_base
<222>  (34)..(34)
<223>  2'-O-methyl modified

<220>  
<221>  modified_base
<222>  (35)..(35)
<223>  2'-O-methyl modified

<220>  
<221>  modified_base
<222>  (36)..(36)
<223>  2'-O-methyl modified

<400>  983
aauucaucaa ccccaucuua gcagccgaaa ggcugc                                 36


<210>  984
<211>  36
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  Modified sense strand


<220>
<221>  misc_feature
<222>  (1)..(2)
<223>  linked via phosphorothioate

<220>  
<221>  modified_base
<222>  (1)..(1)
<223>  2'-O-methyl modified

<220>  
<221>  modified_base
<222>  (2)..(2)
<223>  2'-O-methyl modified

<220>  
<221>  modified_base
<222>  (3)..(3)
<223>  2'-O-methyl modified

<220>  
<221>  modified_base
<222>  (4)..(4)
<223>  2'-O-methyl modified

<220>  
<221>  modified_base
<222>  (5)..(5)
<223>  2'-O-methyl modified

<220>  
<221>  modified_base
<222>  (6)..(6)
<223>  2'-O-methyl modified

<220>  
<221>  modified_base
<222>  (7)..(7)
<223>  2'-O-methyl modified

<220>  
<221>  modified_base
<222>  (8)..(8)
<223>  2'-fluoro modified

<220>  
<221>  modified_base
<222>  (9)..(9)
<223>  2'-fluoro modified

<220>  
<221>  modified_base
<222>  (10)..(10)
<223>  2'-fluoro modified

<220>  
<221>  modified_base
<222>  (11)..(11)
<223>  2'-fluoro modified

<220>  
<221>  modified_base
<222>  (12)..(12)
<223>  2'-O-methyl modified

<220>  
<221>  modified_base
<222>  (13)..(13)
<223>  2'-O-methyl modified

<220>  
<221>  modified_base
<222>  (14)..(14)
<223>  2'-O-methyl modified

<220>  
<221>  modified_base
<222>  (15)..(15)
<223>  2'-O-methyl modified

<220>  
<221>  modified_base
<222>  (16)..(16)
<223>  2'-O-methyl modified

<220>  
<221>  modified_base
<222>  (17)..(17)
<223>  2'-O-methyl modified

<220>  
<221>  modified_base
<222>  (18)..(18)
<223>  2'-O-methyl modified

<220>  
<221>  modified_base
<222>  (19)..(19)
<223>  2'-O-methyl modified

<220>  
<221>  modified_base
<222>  (20)..(20)
<223>  2'-O-methyl modified

<220>  
<221>  modified_base
<222>  (21)..(21)
<223>  2'-O-methyl modified

<220>  
<221>  modified_base
<222>  (22)..(22)
<223>  2'-O-methyl modified

<220>  
<221>  modified_base
<222>  (23)..(23)
<223>  2'-O-methyl modified

<220>  
<221>  modified_base
<222>  (24)..(24)
<223>  2'-O-methyl modified

<220>  
<221>  modified_base
<222>  (25)..(25)
<223>  2'-O-methyl modified

<220>  
<221>  modified_base
<222>  (26)..(26)
<223>  2'-O-methyl modified

<220>  
<221>  modified_base
<222>  (27)..(27)
<223>  2'-O-methyl modified

<220>  
<221>  modified_base
<222>  (28)..(28)
<223>  GalNAc-conjugated

<220>  
<221>  modified_base
<222>  (29)..(29)
<223>  GalNAc-conjugated

<220>  
<221>  modified_base
<222>  (30)..(30)
<223>  GalNAc-conjugated

<220>  
<221>  modified_base
<222>  (31)..(31)
<223>  2'-O-methyl modified

<220>  
<221>  modified_base
<222>  (32)..(32)
<223>  2'-O-methyl modified

<220>  
<221>  modified_base
<222>  (33)..(33)
<223>  2'-O-methyl modified

<220>  
<221>  modified_base
<222>  (34)..(34)
<223>  2'-O-methyl modified

<220>  
<221>  modified_base
<222>  (35)..(35)
<223>  2'-O-methyl modified

<220>  
<221>  modified_base
<222>  (36)..(36)
<223>  2'-O-methyl modified

<400>  984
auucaucaac cccaucuuca gcagccgaaa ggcugc                                 36


<210>  985
<211>  36
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  Modified sense strand


<220>
<221>  misc_feature
<222>  (1)..(2)
<223>  linked via phosphorothioate

<220>  
<221>  modified_base
<222>  (1)..(1)
<223>  2'-O-methyl modified

<220>  
<221>  modified_base
<222>  (2)..(2)
<223>  2'-O-methyl modified

<220>  
<221>  modified_base
<222>  (3)..(3)
<223>  2'-O-methyl modified

<220>  
<221>  modified_base
<222>  (4)..(4)
<223>  2'-O-methyl modified

<220>  
<221>  modified_base
<222>  (5)..(5)
<223>  2'-O-methyl modified

<220>  
<221>  modified_base
<222>  (6)..(6)
<223>  2'-O-methyl modified

<220>  
<221>  modified_base
<222>  (7)..(7)
<223>  2'-O-methyl modified

<220>  
<221>  modified_base
<222>  (8)..(8)
<223>  2'-fluoro modified

<220>  
<221>  modified_base
<222>  (9)..(9)
<223>  2'-fluoro modified

<220>  
<221>  modified_base
<222>  (10)..(10)
<223>  2'-fluoro modified

<220>  
<221>  modified_base
<222>  (11)..(11)
<223>  2'-fluoro modified

<220>  
<221>  modified_base
<222>  (12)..(12)
<223>  2'-O-methyl modified

<220>  
<221>  modified_base
<222>  (13)..(13)
<223>  2'-O-methyl modified

<220>  
<221>  modified_base
<222>  (14)..(14)
<223>  2'-O-methyl modified

<220>  
<221>  modified_base
<222>  (15)..(15)
<223>  2'-O-methyl modified

<220>  
<221>  modified_base
<222>  (16)..(16)
<223>  2'-O-methyl modified

<220>  
<221>  modified_base
<222>  (17)..(17)
<223>  2'-O-methyl modified

<220>  
<221>  modified_base
<222>  (18)..(18)
<223>  2'-O-methyl modified

<220>  
<221>  modified_base
<222>  (19)..(19)
<223>  2'-O-methyl modified

<220>  
<221>  modified_base
<222>  (20)..(20)
<223>  2'-O-methyl modified

<220>  
<221>  modified_base
<222>  (21)..(21)
<223>  2'-O-methyl modified

<220>  
<221>  modified_base
<222>  (22)..(22)
<223>  2'-O-methyl modified

<220>  
<221>  modified_base
<222>  (23)..(23)
<223>  2'-O-methyl modified

<220>  
<221>  modified_base
<222>  (24)..(24)
<223>  2'-O-methyl modified

<220>  
<221>  modified_base
<222>  (25)..(25)
<223>  2'-O-methyl modified

<220>  
<221>  modified_base
<222>  (26)..(26)
<223>  2'-O-methyl modified

<220>  
<221>  modified_base
<222>  (27)..(27)
<223>  2'-O-methyl modified

<220>  
<221>  modified_base
<222>  (28)..(28)
<223>  GalNAc-conjugated

<220>  
<221>  modified_base
<222>  (29)..(29)
<223>  GalNAc-conjugated

<220>  
<221>  modified_base
<222>  (30)..(30)
<223>  GalNAc-conjugated

<220>  
<221>  modified_base
<222>  (31)..(31)
<223>  2'-O-methyl modified

<220>  
<221>  modified_base
<222>  (32)..(32)
<223>  2'-O-methyl modified

<220>  
<221>  modified_base
<222>  (33)..(33)
<223>  2'-O-methyl modified

<220>  
<221>  modified_base
<222>  (34)..(34)
<223>  2'-O-methyl modified

<220>  
<221>  modified_base
<222>  (35)..(35)
<223>  2'-O-methyl modified

<220>  
<221>  modified_base
<222>  (36)..(36)
<223>  2'-O-methyl modified

<400>  985
uucaucaacc ccaucuucga gcagccgaaa ggcugc                                 36


<210>  986
<211>  36
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  Modified sense strand


<220>
<221>  misc_feature
<222>  (1)..(2)
<223>  linked via phosphorothioate

<220>  
<221>  modified_base
<222>  (1)..(1)
<223>  2'-O-methyl modified

<220>  
<221>  modified_base
<222>  (2)..(2)
<223>  2'-O-methyl modified

<220>  
<221>  modified_base
<222>  (3)..(3)
<223>  2'-O-methyl modified

<220>  
<221>  modified_base
<222>  (4)..(4)
<223>  2'-O-methyl modified

<220>  
<221>  modified_base
<222>  (5)..(5)
<223>  2'-O-methyl modified

<220>  
<221>  modified_base
<222>  (6)..(6)
<223>  2'-O-methyl modified

<220>  
<221>  modified_base
<222>  (7)..(7)
<223>  2'-O-methyl modified

<220>  
<221>  modified_base
<222>  (8)..(8)
<223>  2'-fluoro modified

<220>  
<221>  modified_base
<222>  (9)..(9)
<223>  2'-fluoro modified

<220>  
<221>  modified_base
<222>  (10)..(10)
<223>  2'-fluoro modified

<220>  
<221>  modified_base
<222>  (11)..(11)
<223>  2'-fluoro modified

<220>  
<221>  modified_base
<222>  (12)..(12)
<223>  2'-O-methyl modified

<220>  
<221>  modified_base
<222>  (13)..(13)
<223>  2'-O-methyl modified

<220>  
<221>  modified_base
<222>  (14)..(14)
<223>  2'-O-methyl modified

<220>  
<221>  modified_base
<222>  (15)..(15)
<223>  2'-O-methyl modified

<220>  
<221>  modified_base
<222>  (16)..(16)
<223>  2'-O-methyl modified

<220>  
<221>  modified_base
<222>  (17)..(17)
<223>  2'-O-methyl modified

<220>  
<221>  modified_base
<222>  (18)..(18)
<223>  2'-O-methyl modified

<220>  
<221>  modified_base
<222>  (19)..(19)
<223>  2'-O-methyl modified

<220>  
<221>  modified_base
<222>  (20)..(20)
<223>  2'-O-methyl modified

<220>  
<221>  modified_base
<222>  (21)..(21)
<223>  2'-O-methyl modified

<220>  
<221>  modified_base
<222>  (22)..(22)
<223>  2'-O-methyl modified

<220>  
<221>  modified_base
<222>  (23)..(23)
<223>  2'-O-methyl modified

<220>  
<221>  modified_base
<222>  (24)..(24)
<223>  2'-O-methyl modified

<220>  
<221>  modified_base
<222>  (25)..(25)
<223>  2'-O-methyl modified

<220>  
<221>  modified_base
<222>  (26)..(26)
<223>  2'-O-methyl modified

<220>  
<221>  modified_base
<222>  (27)..(27)
<223>  2'-O-methyl modified

<220>  
<221>  modified_base
<222>  (28)..(28)
<223>  GalNAc-conjugated

<220>  
<221>  modified_base
<222>  (29)..(29)
<223>  GalNAc-conjugated

<220>  
<221>  modified_base
<222>  (30)..(30)
<223>  GalNAc-conjugated

<220>  
<221>  modified_base
<222>  (31)..(31)
<223>  2'-O-methyl modified

<220>  
<221>  modified_base
<222>  (32)..(32)
<223>  2'-O-methyl modified

<220>  
<221>  modified_base
<222>  (33)..(33)
<223>  2'-O-methyl modified

<220>  
<221>  modified_base
<222>  (34)..(34)
<223>  2'-O-methyl modified

<220>  
<221>  modified_base
<222>  (35)..(35)
<223>  2'-O-methyl modified

<220>  
<221>  modified_base
<222>  (36)..(36)
<223>  2'-O-methyl modified

<400>  986
ugcagcacac auauguggaa gcagccgaaa ggcugc                                 36


<210>  987
<211>  36
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  Modified sense strand


<220>
<221>  misc_feature
<222>  (1)..(2)
<223>  linked via phosphorothioate

<220>  
<221>  modified_base
<222>  (1)..(1)
<223>  2'-O-methyl modified

<220>  
<221>  modified_base
<222>  (2)..(2)
<223>  2'-O-methyl modified

<220>  
<221>  modified_base
<222>  (3)..(3)
<223>  2'-O-methyl modified

<220>  
<221>  modified_base
<222>  (4)..(4)
<223>  2'-O-methyl modified

<220>  
<221>  modified_base
<222>  (5)..(5)
<223>  2'-O-methyl modified

<220>  
<221>  modified_base
<222>  (6)..(6)
<223>  2'-O-methyl modified

<220>  
<221>  modified_base
<222>  (7)..(7)
<223>  2'-O-methyl modified

<220>  
<221>  modified_base
<222>  (8)..(8)
<223>  2'-fluoro modified

<220>  
<221>  modified_base
<222>  (9)..(9)
<223>  2'-fluoro modified

<220>  
<221>  modified_base
<222>  (10)..(10)
<223>  2'-fluoro modified

<220>  
<221>  modified_base
<222>  (11)..(11)
<223>  2'-fluoro modified

<220>  
<221>  modified_base
<222>  (12)..(12)
<223>  2'-O-methyl modified

<220>  
<221>  modified_base
<222>  (13)..(13)
<223>  2'-O-methyl modified

<220>  
<221>  modified_base
<222>  (14)..(14)
<223>  2'-O-methyl modified

<220>  
<221>  modified_base
<222>  (15)..(15)
<223>  2'-O-methyl modified

<220>  
<221>  modified_base
<222>  (16)..(16)
<223>  2'-O-methyl modified

<220>  
<221>  modified_base
<222>  (17)..(17)
<223>  2'-O-methyl modified

<220>  
<221>  modified_base
<222>  (18)..(18)
<223>  2'-O-methyl modified

<220>  
<221>  modified_base
<222>  (19)..(19)
<223>  2'-O-methyl modified

<220>  
<221>  modified_base
<222>  (20)..(20)
<223>  2'-O-methyl modified

<220>  
<221>  modified_base
<222>  (21)..(21)
<223>  2'-O-methyl modified

<220>  
<221>  modified_base
<222>  (22)..(22)
<223>  2'-O-methyl modified

<220>  
<221>  modified_base
<222>  (23)..(23)
<223>  2'-O-methyl modified

<220>  
<221>  modified_base
<222>  (24)..(24)
<223>  2'-O-methyl modified

<220>  
<221>  modified_base
<222>  (25)..(25)
<223>  2'-O-methyl modified

<220>  
<221>  modified_base
<222>  (26)..(26)
<223>  2'-O-methyl modified

<220>  
<221>  modified_base
<222>  (27)..(27)
<223>  2'-O-methyl modified

<220>  
<221>  modified_base
<222>  (28)..(28)
<223>  GalNAc-conjugated

<220>  
<221>  modified_base
<222>  (29)..(29)
<223>  GalNAc-conjugated

<220>  
<221>  modified_base
<222>  (30)..(30)
<223>  GalNAc-conjugated

<220>  
<221>  modified_base
<222>  (31)..(31)
<223>  2'-O-methyl modified

<220>  
<221>  modified_base
<222>  (32)..(32)
<223>  2'-O-methyl modified

<220>  
<221>  modified_base
<222>  (33)..(33)
<223>  2'-O-methyl modified

<220>  
<221>  modified_base
<222>  (34)..(34)
<223>  2'-O-methyl modified

<220>  
<221>  modified_base
<222>  (35)..(35)
<223>  2'-O-methyl modified

<220>  
<221>  modified_base
<222>  (36)..(36)
<223>  2'-O-methyl modified

<400>  987
gcacacauau guggaagcca gcagccgaaa ggcugc                                 36


<210>  988
<211>  36
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  Modified sense strand


<220>
<221>  misc_feature
<222>  (1)..(2)
<223>  linked via phosphorothioate

<220>  
<221>  modified_base
<222>  (1)..(1)
<223>  2'-O-methyl modified

<220>  
<221>  modified_base
<222>  (2)..(2)
<223>  2'-O-methyl modified

<220>  
<221>  modified_base
<222>  (3)..(3)
<223>  2'-O-methyl modified

<220>  
<221>  modified_base
<222>  (4)..(4)
<223>  2'-O-methyl modified

<220>  
<221>  modified_base
<222>  (5)..(5)
<223>  2'-O-methyl modified

<220>  
<221>  modified_base
<222>  (6)..(6)
<223>  2'-O-methyl modified

<220>  
<221>  modified_base
<222>  (7)..(7)
<223>  2'-O-methyl modified

<220>  
<221>  modified_base
<222>  (8)..(8)
<223>  2'-fluoro modified

<220>  
<221>  modified_base
<222>  (9)..(9)
<223>  2'-fluoro modified

<220>  
<221>  modified_base
<222>  (10)..(10)
<223>  2'-fluoro modified

<220>  
<221>  modified_base
<222>  (11)..(11)
<223>  2'-fluoro modified

<220>  
<221>  modified_base
<222>  (12)..(12)
<223>  2'-O-methyl modified

<220>  
<221>  modified_base
<222>  (13)..(13)
<223>  2'-O-methyl modified

<220>  
<221>  modified_base
<222>  (14)..(14)
<223>  2'-O-methyl modified

<220>  
<221>  modified_base
<222>  (15)..(15)
<223>  2'-O-methyl modified

<220>  
<221>  modified_base
<222>  (16)..(16)
<223>  2'-O-methyl modified

<220>  
<221>  modified_base
<222>  (17)..(17)
<223>  2'-O-methyl modified

<220>  
<221>  modified_base
<222>  (18)..(18)
<223>  2'-O-methyl modified

<220>  
<221>  modified_base
<222>  (19)..(19)
<223>  2'-O-methyl modified

<220>  
<221>  modified_base
<222>  (20)..(20)
<223>  2'-O-methyl modified

<220>  
<221>  modified_base
<222>  (21)..(21)
<223>  2'-O-methyl modified

<220>  
<221>  modified_base
<222>  (22)..(22)
<223>  2'-O-methyl modified

<220>  
<221>  modified_base
<222>  (23)..(23)
<223>  2'-O-methyl modified

<220>  
<221>  modified_base
<222>  (24)..(24)
<223>  2'-O-methyl modified

<220>  
<221>  modified_base
<222>  (25)..(25)
<223>  2'-O-methyl modified

<220>  
<221>  modified_base
<222>  (26)..(26)
<223>  2'-O-methyl modified

<220>  
<221>  modified_base
<222>  (27)..(27)
<223>  2'-O-methyl modified

<220>  
<221>  modified_base
<222>  (28)..(28)
<223>  GalNAc-conjugated

<220>  
<221>  modified_base
<222>  (29)..(29)
<223>  GalNAc-conjugated

<220>  
<221>  modified_base
<222>  (30)..(30)
<223>  GalNAc-conjugated

<220>  
<221>  modified_base
<222>  (31)..(31)
<223>  2'-O-methyl modified

<220>  
<221>  modified_base
<222>  (32)..(32)
<223>  2'-O-methyl modified

<220>  
<221>  modified_base
<222>  (33)..(33)
<223>  2'-O-methyl modified

<220>  
<221>  modified_base
<222>  (34)..(34)
<223>  2'-O-methyl modified

<220>  
<221>  modified_base
<222>  (35)..(35)
<223>  2'-O-methyl modified

<220>  
<221>  modified_base
<222>  (36)..(36)
<223>  2'-O-methyl modified

<400>  988
ugcaugccua cgucuccaua gcagccgaaa ggcugc                                 36


<210>  989
<211>  36
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  Modified sense strand


<220>
<221>  misc_feature
<222>  (1)..(2)
<223>  linked via phosphorothioate

<220>  
<221>  modified_base
<222>  (1)..(1)
<223>  2'-O-methyl modified

<220>  
<221>  modified_base
<222>  (2)..(2)
<223>  2'-O-methyl modified

<220>  
<221>  modified_base
<222>  (3)..(3)
<223>  2'-O-methyl modified

<220>  
<221>  modified_base
<222>  (4)..(4)
<223>  2'-O-methyl modified

<220>  
<221>  modified_base
<222>  (5)..(5)
<223>  2'-O-methyl modified

<220>  
<221>  modified_base
<222>  (6)..(6)
<223>  2'-O-methyl modified

<220>  
<221>  modified_base
<222>  (7)..(7)
<223>  2'-O-methyl modified

<220>  
<221>  modified_base
<222>  (8)..(8)
<223>  2'-fluoro modified

<220>  
<221>  modified_base
<222>  (9)..(9)
<223>  2'-fluoro modified

<220>  
<221>  modified_base
<222>  (10)..(10)
<223>  2'-fluoro modified

<220>  
<221>  modified_base
<222>  (11)..(11)
<223>  2'-fluoro modified

<220>  
<221>  modified_base
<222>  (12)..(12)
<223>  2'-O-methyl modified

<220>  
<221>  modified_base
<222>  (13)..(13)
<223>  2'-O-methyl modified

<220>  
<221>  modified_base
<222>  (14)..(14)
<223>  2'-O-methyl modified

<220>  
<221>  modified_base
<222>  (15)..(15)
<223>  2'-O-methyl modified

<220>  
<221>  modified_base
<222>  (16)..(16)
<223>  2'-O-methyl modified

<220>  
<221>  modified_base
<222>  (17)..(17)
<223>  2'-O-methyl modified

<220>  
<221>  modified_base
<222>  (18)..(18)
<223>  2'-O-methyl modified

<220>  
<221>  modified_base
<222>  (19)..(19)
<223>  2'-O-methyl modified

<220>  
<221>  modified_base
<222>  (20)..(20)
<223>  2'-O-methyl modified

<220>  
<221>  modified_base
<222>  (21)..(21)
<223>  2'-O-methyl modified

<220>  
<221>  modified_base
<222>  (22)..(22)
<223>  2'-O-methyl modified

<220>  
<221>  modified_base
<222>  (23)..(23)
<223>  2'-O-methyl modified

<220>  
<221>  modified_base
<222>  (24)..(24)
<223>  2'-O-methyl modified

<220>  
<221>  modified_base
<222>  (25)..(25)
<223>  2'-O-methyl modified

<220>  
<221>  modified_base
<222>  (26)..(26)
<223>  2'-O-methyl modified

<220>  
<221>  modified_base
<222>  (27)..(27)
<223>  2'-O-methyl modified

<220>  
<221>  modified_base
<222>  (28)..(28)
<223>  GalNAc-conjugated

<220>  
<221>  modified_base
<222>  (29)..(29)
<223>  GalNAc-conjugated

<220>  
<221>  modified_base
<222>  (30)..(30)
<223>  GalNAc-conjugated

<220>  
<221>  modified_base
<222>  (31)..(31)
<223>  2'-O-methyl modified

<220>  
<221>  modified_base
<222>  (32)..(32)
<223>  2'-O-methyl modified

<220>  
<221>  modified_base
<222>  (33)..(33)
<223>  2'-O-methyl modified

<220>  
<221>  modified_base
<222>  (34)..(34)
<223>  2'-O-methyl modified

<220>  
<221>  modified_base
<222>  (35)..(35)
<223>  2'-O-methyl modified

<220>  
<221>  modified_base
<222>  (36)..(36)
<223>  2'-O-methyl modified

<400>  989
ugccuacguc uccauccaca gcagccgaaa ggcugc                                 36


<210>  990
<211>  36
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  Modified sense strand


<220>
<221>  misc_feature
<222>  (1)..(2)
<223>  linked via phosphorothioate

<220>  
<221>  modified_base
<222>  (1)..(1)
<223>  2'-O-methyl modified

<220>  
<221>  modified_base
<222>  (2)..(2)
<223>  2'-O-methyl modified

<220>  
<221>  modified_base
<222>  (3)..(3)
<223>  2'-O-methyl modified

<220>  
<221>  modified_base
<222>  (4)..(4)
<223>  2'-O-methyl modified

<220>  
<221>  modified_base
<222>  (5)..(5)
<223>  2'-O-methyl modified

<220>  
<221>  modified_base
<222>  (6)..(6)
<223>  2'-O-methyl modified

<220>  
<221>  modified_base
<222>  (7)..(7)
<223>  2'-O-methyl modified

<220>  
<221>  modified_base
<222>  (8)..(8)
<223>  2'-fluoro modified

<220>  
<221>  modified_base
<222>  (9)..(9)
<223>  2'-fluoro modified

<220>  
<221>  modified_base
<222>  (10)..(10)
<223>  2'-fluoro modified

<220>  
<221>  modified_base
<222>  (11)..(11)
<223>  2'-fluoro modified

<220>  
<221>  modified_base
<222>  (12)..(12)
<223>  2'-O-methyl modified

<220>  
<221>  modified_base
<222>  (13)..(13)
<223>  2'-O-methyl modified

<220>  
<221>  modified_base
<222>  (14)..(14)
<223>  2'-O-methyl modified

<220>  
<221>  modified_base
<222>  (15)..(15)
<223>  2'-O-methyl modified

<220>  
<221>  modified_base
<222>  (16)..(16)
<223>  2'-O-methyl modified

<220>  
<221>  modified_base
<222>  (17)..(17)
<223>  2'-O-methyl modified

<220>  
<221>  modified_base
<222>  (18)..(18)
<223>  2'-O-methyl modified

<220>  
<221>  modified_base
<222>  (19)..(19)
<223>  2'-O-methyl modified

<220>  
<221>  modified_base
<222>  (20)..(20)
<223>  2'-O-methyl modified

<220>  
<221>  modified_base
<222>  (21)..(21)
<223>  2'-O-methyl modified

<220>  
<221>  modified_base
<222>  (22)..(22)
<223>  2'-O-methyl modified

<220>  
<221>  modified_base
<222>  (23)..(23)
<223>  2'-O-methyl modified

<220>  
<221>  modified_base
<222>  (24)..(24)
<223>  2'-O-methyl modified

<220>  
<221>  modified_base
<222>  (25)..(25)
<223>  2'-O-methyl modified

<220>  
<221>  modified_base
<222>  (26)..(26)
<223>  2'-O-methyl modified

<220>  
<221>  modified_base
<222>  (27)..(27)
<223>  2'-O-methyl modified

<220>  
<221>  modified_base
<222>  (28)..(28)
<223>  GalNAc-conjugated

<220>  
<221>  modified_base
<222>  (29)..(29)
<223>  GalNAc-conjugated

<220>  
<221>  modified_base
<222>  (30)..(30)
<223>  GalNAc-conjugated

<220>  
<221>  modified_base
<222>  (31)..(31)
<223>  2'-O-methyl modified

<220>  
<221>  modified_base
<222>  (32)..(32)
<223>  2'-O-methyl modified

<220>  
<221>  modified_base
<222>  (33)..(33)
<223>  2'-O-methyl modified

<220>  
<221>  modified_base
<222>  (34)..(34)
<223>  2'-O-methyl modified

<220>  
<221>  modified_base
<222>  (35)..(35)
<223>  2'-O-methyl modified

<220>  
<221>  modified_base
<222>  (36)..(36)
<223>  2'-O-methyl modified

<400>  990
uacgucucca uccaccauca gcagccgaaa ggcugc                                 36


<210>  991
<211>  36
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  Modified sense strand


<220>
<221>  misc_feature
<222>  (1)..(2)
<223>  linked via phosphorothioate

<220>  
<221>  modified_base
<222>  (1)..(1)
<223>  2'-O-methyl modified

<220>  
<221>  modified_base
<222>  (2)..(2)
<223>  2'-O-methyl modified

<220>  
<221>  modified_base
<222>  (3)..(3)
<223>  2'-O-methyl modified

<220>  
<221>  modified_base
<222>  (4)..(4)
<223>  2'-O-methyl modified

<220>  
<221>  modified_base
<222>  (5)..(5)
<223>  2'-O-methyl modified

<220>  
<221>  modified_base
<222>  (6)..(6)
<223>  2'-O-methyl modified

<220>  
<221>  modified_base
<222>  (7)..(7)
<223>  2'-O-methyl modified

<220>  
<221>  modified_base
<222>  (8)..(8)
<223>  2'-fluoro modified

<220>  
<221>  modified_base
<222>  (9)..(9)
<223>  2'-fluoro modified

<220>  
<221>  modified_base
<222>  (10)..(10)
<223>  2'-fluoro modified

<220>  
<221>  modified_base
<222>  (11)..(11)
<223>  2'-fluoro modified

<220>  
<221>  modified_base
<222>  (12)..(12)
<223>  2'-O-methyl modified

<220>  
<221>  modified_base
<222>  (13)..(13)
<223>  2'-O-methyl modified

<220>  
<221>  modified_base
<222>  (14)..(14)
<223>  2'-O-methyl modified

<220>  
<221>  modified_base
<222>  (15)..(15)
<223>  2'-O-methyl modified

<220>  
<221>  modified_base
<222>  (16)..(16)
<223>  2'-O-methyl modified

<220>  
<221>  modified_base
<222>  (17)..(17)
<223>  2'-O-methyl modified

<220>  
<221>  modified_base
<222>  (18)..(18)
<223>  2'-O-methyl modified

<220>  
<221>  modified_base
<222>  (19)..(19)
<223>  2'-O-methyl modified

<220>  
<221>  modified_base
<222>  (20)..(20)
<223>  2'-O-methyl modified

<220>  
<221>  modified_base
<222>  (21)..(21)
<223>  2'-O-methyl modified

<220>  
<221>  modified_base
<222>  (22)..(22)
<223>  2'-O-methyl modified

<220>  
<221>  modified_base
<222>  (23)..(23)
<223>  2'-O-methyl modified

<220>  
<221>  modified_base
<222>  (24)..(24)
<223>  2'-O-methyl modified

<220>  
<221>  modified_base
<222>  (25)..(25)
<223>  2'-O-methyl modified

<220>  
<221>  modified_base
<222>  (26)..(26)
<223>  2'-O-methyl modified

<220>  
<221>  modified_base
<222>  (27)..(27)
<223>  2'-O-methyl modified

<220>  
<221>  modified_base
<222>  (28)..(28)
<223>  GalNAc-conjugated

<220>  
<221>  modified_base
<222>  (29)..(29)
<223>  GalNAc-conjugated

<220>  
<221>  modified_base
<222>  (30)..(30)
<223>  GalNAc-conjugated

<220>  
<221>  modified_base
<222>  (31)..(31)
<223>  2'-O-methyl modified

<220>  
<221>  modified_base
<222>  (32)..(32)
<223>  2'-O-methyl modified

<220>  
<221>  modified_base
<222>  (33)..(33)
<223>  2'-O-methyl modified

<220>  
<221>  modified_base
<222>  (34)..(34)
<223>  2'-O-methyl modified

<220>  
<221>  modified_base
<222>  (35)..(35)
<223>  2'-O-methyl modified

<220>  
<221>  modified_base
<222>  (36)..(36)
<223>  2'-O-methyl modified

<400>  991
cgucuccauc caccauccca gcagccgaaa ggcugc                                 36


<210>  992
<211>  36
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  Modified sense strand


<220>
<221>  misc_feature
<222>  (1)..(2)
<223>  linked via phosphorothioate

<220>  
<221>  modified_base
<222>  (1)..(1)
<223>  2'-O-methyl modified

<220>  
<221>  modified_base
<222>  (2)..(2)
<223>  2'-O-methyl modified

<220>  
<221>  modified_base
<222>  (3)..(3)
<223>  2'-O-methyl modified

<220>  
<221>  modified_base
<222>  (4)..(4)
<223>  2'-O-methyl modified

<220>  
<221>  modified_base
<222>  (5)..(5)
<223>  2'-O-methyl modified

<220>  
<221>  modified_base
<222>  (6)..(6)
<223>  2'-O-methyl modified

<220>  
<221>  modified_base
<222>  (7)..(7)
<223>  2'-O-methyl modified

<220>  
<221>  modified_base
<222>  (8)..(8)
<223>  2'-fluoro modified

<220>  
<221>  modified_base
<222>  (9)..(9)
<223>  2'-fluoro modified

<220>  
<221>  modified_base
<222>  (10)..(10)
<223>  2'-fluoro modified

<220>  
<221>  modified_base
<222>  (11)..(11)
<223>  2'-fluoro modified

<220>  
<221>  modified_base
<222>  (12)..(12)
<223>  2'-O-methyl modified

<220>  
<221>  modified_base
<222>  (13)..(13)
<223>  2'-O-methyl modified

<220>  
<221>  modified_base
<222>  (14)..(14)
<223>  2'-O-methyl modified

<220>  
<221>  modified_base
<222>  (15)..(15)
<223>  2'-O-methyl modified

<220>  
<221>  modified_base
<222>  (16)..(16)
<223>  2'-O-methyl modified

<220>  
<221>  modified_base
<222>  (17)..(17)
<223>  2'-O-methyl modified

<220>  
<221>  modified_base
<222>  (18)..(18)
<223>  2'-O-methyl modified

<220>  
<221>  modified_base
<222>  (19)..(19)
<223>  2'-O-methyl modified

<220>  
<221>  modified_base
<222>  (20)..(20)
<223>  2'-O-methyl modified

<220>  
<221>  modified_base
<222>  (21)..(21)
<223>  2'-O-methyl modified

<220>  
<221>  modified_base
<222>  (22)..(22)
<223>  2'-O-methyl modified

<220>  
<221>  modified_base
<222>  (23)..(23)
<223>  2'-O-methyl modified

<220>  
<221>  modified_base
<222>  (24)..(24)
<223>  2'-O-methyl modified

<220>  
<221>  modified_base
<222>  (25)..(25)
<223>  2'-O-methyl modified

<220>  
<221>  modified_base
<222>  (26)..(26)
<223>  2'-O-methyl modified

<220>  
<221>  modified_base
<222>  (27)..(27)
<223>  2'-O-methyl modified

<220>  
<221>  modified_base
<222>  (28)..(28)
<223>  GalNAc-conjugated

<220>  
<221>  modified_base
<222>  (29)..(29)
<223>  GalNAc-conjugated

<220>  
<221>  modified_base
<222>  (30)..(30)
<223>  GalNAc-conjugated

<220>  
<221>  modified_base
<222>  (31)..(31)
<223>  2'-O-methyl modified

<220>  
<221>  modified_base
<222>  (32)..(32)
<223>  2'-O-methyl modified

<220>  
<221>  modified_base
<222>  (33)..(33)
<223>  2'-O-methyl modified

<220>  
<221>  modified_base
<222>  (34)..(34)
<223>  2'-O-methyl modified

<220>  
<221>  modified_base
<222>  (35)..(35)
<223>  2'-O-methyl modified

<220>  
<221>  modified_base
<222>  (36)..(36)
<223>  2'-O-methyl modified

<400>  992
auccaccauc cccaugacca gcagccgaaa ggcugc                                 36


<210>  993
<211>  36
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  Modified sense strand


<220>
<221>  misc_feature
<222>  (1)..(2)
<223>  linked via phosphorothioate

<220>  
<221>  modified_base
<222>  (1)..(1)
<223>  2'-O-methyl modified

<220>  
<221>  modified_base
<222>  (2)..(2)
<223>  2'-O-methyl modified

<220>  
<221>  modified_base
<222>  (3)..(3)
<223>  2'-O-methyl modified

<220>  
<221>  modified_base
<222>  (4)..(4)
<223>  2'-O-methyl modified

<220>  
<221>  modified_base
<222>  (5)..(5)
<223>  2'-O-methyl modified

<220>  
<221>  modified_base
<222>  (6)..(6)
<223>  2'-O-methyl modified

<220>  
<221>  modified_base
<222>  (7)..(7)
<223>  2'-O-methyl modified

<220>  
<221>  modified_base
<222>  (8)..(8)
<223>  2'-fluoro modified

<220>  
<221>  modified_base
<222>  (9)..(9)
<223>  2'-fluoro modified

<220>  
<221>  modified_base
<222>  (10)..(10)
<223>  2'-fluoro modified

<220>  
<221>  modified_base
<222>  (11)..(11)
<223>  2'-fluoro modified

<220>  
<221>  modified_base
<222>  (12)..(12)
<223>  2'-O-methyl modified

<220>  
<221>  modified_base
<222>  (13)..(13)
<223>  2'-O-methyl modified

<220>  
<221>  modified_base
<222>  (14)..(14)
<223>  2'-O-methyl modified

<220>  
<221>  modified_base
<222>  (15)..(15)
<223>  2'-O-methyl modified

<220>  
<221>  modified_base
<222>  (16)..(16)
<223>  2'-O-methyl modified

<220>  
<221>  modified_base
<222>  (17)..(17)
<223>  2'-O-methyl modified

<220>  
<221>  modified_base
<222>  (18)..(18)
<223>  2'-O-methyl modified

<220>  
<221>  modified_base
<222>  (19)..(19)
<223>  2'-O-methyl modified

<220>  
<221>  modified_base
<222>  (20)..(20)
<223>  2'-O-methyl modified

<220>  
<221>  modified_base
<222>  (21)..(21)
<223>  2'-O-methyl modified

<220>  
<221>  modified_base
<222>  (22)..(22)
<223>  2'-O-methyl modified

<220>  
<221>  modified_base
<222>  (23)..(23)
<223>  2'-O-methyl modified

<220>  
<221>  modified_base
<222>  (24)..(24)
<223>  2'-O-methyl modified

<220>  
<221>  modified_base
<222>  (25)..(25)
<223>  2'-O-methyl modified

<220>  
<221>  modified_base
<222>  (26)..(26)
<223>  2'-O-methyl modified

<220>  
<221>  modified_base
<222>  (27)..(27)
<223>  2'-O-methyl modified

<220>  
<221>  modified_base
<222>  (28)..(28)
<223>  GalNAc-conjugated

<220>  
<221>  modified_base
<222>  (29)..(29)
<223>  GalNAc-conjugated

<220>  
<221>  modified_base
<222>  (30)..(30)
<223>  GalNAc-conjugated

<220>  
<221>  modified_base
<222>  (31)..(31)
<223>  2'-O-methyl modified

<220>  
<221>  modified_base
<222>  (32)..(32)
<223>  2'-O-methyl modified

<220>  
<221>  modified_base
<222>  (33)..(33)
<223>  2'-O-methyl modified

<220>  
<221>  modified_base
<222>  (34)..(34)
<223>  2'-O-methyl modified

<220>  
<221>  modified_base
<222>  (35)..(35)
<223>  2'-O-methyl modified

<220>  
<221>  modified_base
<222>  (36)..(36)
<223>  2'-O-methyl modified

<400>  993
caugaccgac ugauguucca gcagccgaaa ggcugc                                 36


<210>  994
<211>  36
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  Modified sense strand


<220>
<221>  misc_feature
<222>  (1)..(2)
<223>  linked via phosphorothioate

<220>  
<221>  modified_base
<222>  (1)..(1)
<223>  2'-O-methyl modified

<220>  
<221>  modified_base
<222>  (2)..(2)
<223>  2'-O-methyl modified

<220>  
<221>  modified_base
<222>  (3)..(3)
<223>  2'-O-methyl modified

<220>  
<221>  modified_base
<222>  (4)..(4)
<223>  2'-O-methyl modified

<220>  
<221>  modified_base
<222>  (5)..(5)
<223>  2'-O-methyl modified

<220>  
<221>  modified_base
<222>  (6)..(6)
<223>  2'-O-methyl modified

<220>  
<221>  modified_base
<222>  (7)..(7)
<223>  2'-O-methyl modified

<220>  
<221>  modified_base
<222>  (8)..(8)
<223>  2'-fluoro modified

<220>  
<221>  modified_base
<222>  (9)..(9)
<223>  2'-fluoro modified

<220>  
<221>  modified_base
<222>  (10)..(10)
<223>  2'-fluoro modified

<220>  
<221>  modified_base
<222>  (11)..(11)
<223>  2'-fluoro modified

<220>  
<221>  modified_base
<222>  (12)..(12)
<223>  2'-O-methyl modified

<220>  
<221>  modified_base
<222>  (13)..(13)
<223>  2'-O-methyl modified

<220>  
<221>  modified_base
<222>  (14)..(14)
<223>  2'-O-methyl modified

<220>  
<221>  modified_base
<222>  (15)..(15)
<223>  2'-O-methyl modified

<220>  
<221>  modified_base
<222>  (16)..(16)
<223>  2'-O-methyl modified

<220>  
<221>  modified_base
<222>  (17)..(17)
<223>  2'-O-methyl modified

<220>  
<221>  modified_base
<222>  (18)..(18)
<223>  2'-O-methyl modified

<220>  
<221>  modified_base
<222>  (19)..(19)
<223>  2'-O-methyl modified

<220>  
<221>  modified_base
<222>  (20)..(20)
<223>  2'-O-methyl modified

<220>  
<221>  modified_base
<222>  (21)..(21)
<223>  2'-O-methyl modified

<220>  
<221>  modified_base
<222>  (22)..(22)
<223>  2'-O-methyl modified

<220>  
<221>  modified_base
<222>  (23)..(23)
<223>  2'-O-methyl modified

<220>  
<221>  modified_base
<222>  (24)..(24)
<223>  2'-O-methyl modified

<220>  
<221>  modified_base
<222>  (25)..(25)
<223>  2'-O-methyl modified

<220>  
<221>  modified_base
<222>  (26)..(26)
<223>  2'-O-methyl modified

<220>  
<221>  modified_base
<222>  (27)..(27)
<223>  2'-O-methyl modified

<220>  
<221>  modified_base
<222>  (28)..(28)
<223>  GalNAc-conjugated

<220>  
<221>  modified_base
<222>  (29)..(29)
<223>  GalNAc-conjugated

<220>  
<221>  modified_base
<222>  (30)..(30)
<223>  GalNAc-conjugated

<220>  
<221>  modified_base
<222>  (31)..(31)
<223>  2'-O-methyl modified

<220>  
<221>  modified_base
<222>  (32)..(32)
<223>  2'-O-methyl modified

<220>  
<221>  modified_base
<222>  (33)..(33)
<223>  2'-O-methyl modified

<220>  
<221>  modified_base
<222>  (34)..(34)
<223>  2'-O-methyl modified

<220>  
<221>  modified_base
<222>  (35)..(35)
<223>  2'-O-methyl modified

<220>  
<221>  modified_base
<222>  (36)..(36)
<223>  2'-O-methyl modified

<400>  994
ccgacugaug uucccacgga gcagccgaaa ggcugc                                 36


<210>  995
<211>  36
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  Modified sense strand


<220>
<221>  misc_feature
<222>  (1)..(2)
<223>  linked via phosphorothioate

<220>  
<221>  modified_base
<222>  (1)..(1)
<223>  2'-O-methyl modified

<220>  
<221>  modified_base
<222>  (2)..(2)
<223>  2'-O-methyl modified

<220>  
<221>  modified_base
<222>  (3)..(3)
<223>  2'-O-methyl modified

<220>  
<221>  modified_base
<222>  (4)..(4)
<223>  2'-O-methyl modified

<220>  
<221>  modified_base
<222>  (5)..(5)
<223>  2'-O-methyl modified

<220>  
<221>  modified_base
<222>  (6)..(6)
<223>  2'-O-methyl modified

<220>  
<221>  modified_base
<222>  (7)..(7)
<223>  2'-O-methyl modified

<220>  
<221>  modified_base
<222>  (8)..(8)
<223>  2'-fluoro modified

<220>  
<221>  modified_base
<222>  (9)..(9)
<223>  2'-fluoro modified

<220>  
<221>  modified_base
<222>  (10)..(10)
<223>  2'-fluoro modified

<220>  
<221>  modified_base
<222>  (11)..(11)
<223>  2'-fluoro modified

<220>  
<221>  modified_base
<222>  (12)..(12)
<223>  2'-O-methyl modified

<220>  
<221>  modified_base
<222>  (13)..(13)
<223>  2'-O-methyl modified

<220>  
<221>  modified_base
<222>  (14)..(14)
<223>  2'-O-methyl modified

<220>  
<221>  modified_base
<222>  (15)..(15)
<223>  2'-O-methyl modified

<220>  
<221>  modified_base
<222>  (16)..(16)
<223>  2'-O-methyl modified

<220>  
<221>  modified_base
<222>  (17)..(17)
<223>  2'-O-methyl modified

<220>  
<221>  modified_base
<222>  (18)..(18)
<223>  2'-O-methyl modified

<220>  
<221>  modified_base
<222>  (19)..(19)
<223>  2'-O-methyl modified

<220>  
<221>  modified_base
<222>  (20)..(20)
<223>  2'-O-methyl modified

<220>  
<221>  modified_base
<222>  (21)..(21)
<223>  2'-O-methyl modified

<220>  
<221>  modified_base
<222>  (22)..(22)
<223>  2'-O-methyl modified

<220>  
<221>  modified_base
<222>  (23)..(23)
<223>  2'-O-methyl modified

<220>  
<221>  modified_base
<222>  (24)..(24)
<223>  2'-O-methyl modified

<220>  
<221>  modified_base
<222>  (25)..(25)
<223>  2'-O-methyl modified

<220>  
<221>  modified_base
<222>  (26)..(26)
<223>  2'-O-methyl modified

<220>  
<221>  modified_base
<222>  (27)..(27)
<223>  2'-O-methyl modified

<220>  
<221>  modified_base
<222>  (28)..(28)
<223>  GalNAc-conjugated

<220>  
<221>  modified_base
<222>  (29)..(29)
<223>  GalNAc-conjugated

<220>  
<221>  modified_base
<222>  (30)..(30)
<223>  GalNAc-conjugated

<220>  
<221>  modified_base
<222>  (31)..(31)
<223>  2'-O-methyl modified

<220>  
<221>  modified_base
<222>  (32)..(32)
<223>  2'-O-methyl modified

<220>  
<221>  modified_base
<222>  (33)..(33)
<223>  2'-O-methyl modified

<220>  
<221>  modified_base
<222>  (34)..(34)
<223>  2'-O-methyl modified

<220>  
<221>  modified_base
<222>  (35)..(35)
<223>  2'-O-methyl modified

<220>  
<221>  modified_base
<222>  (36)..(36)
<223>  2'-O-methyl modified

<400>  995
cgacugaugu ucccacggaa gcagccgaaa ggcugc                                 36


<210>  996
<211>  36
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  Modified sense strand


<220>
<221>  misc_feature
<222>  (1)..(2)
<223>  linked via phosphorothioate

<220>  
<221>  modified_base
<222>  (1)..(1)
<223>  2'-O-methyl modified

<220>  
<221>  modified_base
<222>  (2)..(2)
<223>  2'-O-methyl modified

<220>  
<221>  modified_base
<222>  (3)..(3)
<223>  2'-O-methyl modified

<220>  
<221>  modified_base
<222>  (4)..(4)
<223>  2'-O-methyl modified

<220>  
<221>  modified_base
<222>  (5)..(5)
<223>  2'-O-methyl modified

<220>  
<221>  modified_base
<222>  (6)..(6)
<223>  2'-O-methyl modified

<220>  
<221>  modified_base
<222>  (7)..(7)
<223>  2'-O-methyl modified

<220>  
<221>  modified_base
<222>  (8)..(8)
<223>  2'-fluoro modified

<220>  
<221>  modified_base
<222>  (9)..(9)
<223>  2'-fluoro modified

<220>  
<221>  modified_base
<222>  (10)..(10)
<223>  2'-fluoro modified

<220>  
<221>  modified_base
<222>  (11)..(11)
<223>  2'-fluoro modified

<220>  
<221>  modified_base
<222>  (12)..(12)
<223>  2'-O-methyl modified

<220>  
<221>  modified_base
<222>  (13)..(13)
<223>  2'-O-methyl modified

<220>  
<221>  modified_base
<222>  (14)..(14)
<223>  2'-O-methyl modified

<220>  
<221>  modified_base
<222>  (15)..(15)
<223>  2'-O-methyl modified

<220>  
<221>  modified_base
<222>  (16)..(16)
<223>  2'-O-methyl modified

<220>  
<221>  modified_base
<222>  (17)..(17)
<223>  2'-O-methyl modified

<220>  
<221>  modified_base
<222>  (18)..(18)
<223>  2'-O-methyl modified

<220>  
<221>  modified_base
<222>  (19)..(19)
<223>  2'-O-methyl modified

<220>  
<221>  modified_base
<222>  (20)..(20)
<223>  2'-O-methyl modified

<220>  
<221>  modified_base
<222>  (21)..(21)
<223>  2'-O-methyl modified

<220>  
<221>  modified_base
<222>  (22)..(22)
<223>  2'-O-methyl modified

<220>  
<221>  modified_base
<222>  (23)..(23)
<223>  2'-O-methyl modified

<220>  
<221>  modified_base
<222>  (24)..(24)
<223>  2'-O-methyl modified

<220>  
<221>  modified_base
<222>  (25)..(25)
<223>  2'-O-methyl modified

<220>  
<221>  modified_base
<222>  (26)..(26)
<223>  2'-O-methyl modified

<220>  
<221>  modified_base
<222>  (27)..(27)
<223>  2'-O-methyl modified

<220>  
<221>  modified_base
<222>  (28)..(28)
<223>  GalNAc-conjugated

<220>  
<221>  modified_base
<222>  (29)..(29)
<223>  GalNAc-conjugated

<220>  
<221>  modified_base
<222>  (30)..(30)
<223>  GalNAc-conjugated

<220>  
<221>  modified_base
<222>  (31)..(31)
<223>  2'-O-methyl modified

<220>  
<221>  modified_base
<222>  (32)..(32)
<223>  2'-O-methyl modified

<220>  
<221>  modified_base
<222>  (33)..(33)
<223>  2'-O-methyl modified

<220>  
<221>  modified_base
<222>  (34)..(34)
<223>  2'-O-methyl modified

<220>  
<221>  modified_base
<222>  (35)..(35)
<223>  2'-O-methyl modified

<220>  
<221>  modified_base
<222>  (36)..(36)
<223>  2'-O-methyl modified

<400>  996
gacugauguu cccacggaua gcagccgaaa ggcugc                                 36


<210>  997
<211>  36
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  Modified sense strand


<220>
<221>  misc_feature
<222>  (1)..(2)
<223>  linked via phosphorothioate

<220>  
<221>  modified_base
<222>  (1)..(1)
<223>  2'-O-methyl modified

<220>  
<221>  modified_base
<222>  (2)..(2)
<223>  2'-O-methyl modified

<220>  
<221>  modified_base
<222>  (3)..(3)
<223>  2'-O-methyl modified

<220>  
<221>  modified_base
<222>  (4)..(4)
<223>  2'-O-methyl modified

<220>  
<221>  modified_base
<222>  (5)..(5)
<223>  2'-O-methyl modified

<220>  
<221>  modified_base
<222>  (6)..(6)
<223>  2'-O-methyl modified

<220>  
<221>  modified_base
<222>  (7)..(7)
<223>  2'-O-methyl modified

<220>  
<221>  modified_base
<222>  (8)..(8)
<223>  2'-fluoro modified

<220>  
<221>  modified_base
<222>  (9)..(9)
<223>  2'-fluoro modified

<220>  
<221>  modified_base
<222>  (10)..(10)
<223>  2'-fluoro modified

<220>  
<221>  modified_base
<222>  (11)..(11)
<223>  2'-fluoro modified

<220>  
<221>  modified_base
<222>  (12)..(12)
<223>  2'-O-methyl modified

<220>  
<221>  modified_base
<222>  (13)..(13)
<223>  2'-O-methyl modified

<220>  
<221>  modified_base
<222>  (14)..(14)
<223>  2'-O-methyl modified

<220>  
<221>  modified_base
<222>  (15)..(15)
<223>  2'-O-methyl modified

<220>  
<221>  modified_base
<222>  (16)..(16)
<223>  2'-O-methyl modified

<220>  
<221>  modified_base
<222>  (17)..(17)
<223>  2'-O-methyl modified

<220>  
<221>  modified_base
<222>  (18)..(18)
<223>  2'-O-methyl modified

<220>  
<221>  modified_base
<222>  (19)..(19)
<223>  2'-O-methyl modified

<220>  
<221>  modified_base
<222>  (20)..(20)
<223>  2'-O-methyl modified

<220>  
<221>  modified_base
<222>  (21)..(21)
<223>  2'-O-methyl modified

<220>  
<221>  modified_base
<222>  (22)..(22)
<223>  2'-O-methyl modified

<220>  
<221>  modified_base
<222>  (23)..(23)
<223>  2'-O-methyl modified

<220>  
<221>  modified_base
<222>  (24)..(24)
<223>  2'-O-methyl modified

<220>  
<221>  modified_base
<222>  (25)..(25)
<223>  2'-O-methyl modified

<220>  
<221>  modified_base
<222>  (26)..(26)
<223>  2'-O-methyl modified

<220>  
<221>  modified_base
<222>  (27)..(27)
<223>  2'-O-methyl modified

<220>  
<221>  modified_base
<222>  (28)..(28)
<223>  GalNAc-conjugated

<220>  
<221>  modified_base
<222>  (29)..(29)
<223>  GalNAc-conjugated

<220>  
<221>  modified_base
<222>  (30)..(30)
<223>  GalNAc-conjugated

<220>  
<221>  modified_base
<222>  (31)..(31)
<223>  2'-O-methyl modified

<220>  
<221>  modified_base
<222>  (32)..(32)
<223>  2'-O-methyl modified

<220>  
<221>  modified_base
<222>  (33)..(33)
<223>  2'-O-methyl modified

<220>  
<221>  modified_base
<222>  (34)..(34)
<223>  2'-O-methyl modified

<220>  
<221>  modified_base
<222>  (35)..(35)
<223>  2'-O-methyl modified

<220>  
<221>  modified_base
<222>  (36)..(36)
<223>  2'-O-methyl modified

<400>  997
cugauguucc cacggaugca gcagccgaaa ggcugc                                 36


<210>  998
<211>  36
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  Modified sense strand


<220>
<221>  misc_feature
<222>  (1)..(2)
<223>  linked via phosphorothioate

<220>  
<221>  modified_base
<222>  (1)..(1)
<223>  2'-O-methyl modified

<220>  
<221>  modified_base
<222>  (2)..(2)
<223>  2'-O-methyl modified

<220>  
<221>  modified_base
<222>  (3)..(3)
<223>  2'-O-methyl modified

<220>  
<221>  modified_base
<222>  (4)..(4)
<223>  2'-O-methyl modified

<220>  
<221>  modified_base
<222>  (5)..(5)
<223>  2'-O-methyl modified

<220>  
<221>  modified_base
<222>  (6)..(6)
<223>  2'-O-methyl modified

<220>  
<221>  modified_base
<222>  (7)..(7)
<223>  2'-O-methyl modified

<220>  
<221>  modified_base
<222>  (8)..(8)
<223>  2'-fluoro modified

<220>  
<221>  modified_base
<222>  (9)..(9)
<223>  2'-fluoro modified

<220>  
<221>  modified_base
<222>  (10)..(10)
<223>  2'-fluoro modified

<220>  
<221>  modified_base
<222>  (11)..(11)
<223>  2'-fluoro modified

<220>  
<221>  modified_base
<222>  (12)..(12)
<223>  2'-O-methyl modified

<220>  
<221>  modified_base
<222>  (13)..(13)
<223>  2'-O-methyl modified

<220>  
<221>  modified_base
<222>  (14)..(14)
<223>  2'-O-methyl modified

<220>  
<221>  modified_base
<222>  (15)..(15)
<223>  2'-O-methyl modified

<220>  
<221>  modified_base
<222>  (16)..(16)
<223>  2'-O-methyl modified

<220>  
<221>  modified_base
<222>  (17)..(17)
<223>  2'-O-methyl modified

<220>  
<221>  modified_base
<222>  (18)..(18)
<223>  2'-O-methyl modified

<220>  
<221>  modified_base
<222>  (19)..(19)
<223>  2'-O-methyl modified

<220>  
<221>  modified_base
<222>  (20)..(20)
<223>  2'-O-methyl modified

<220>  
<221>  modified_base
<222>  (21)..(21)
<223>  2'-O-methyl modified

<220>  
<221>  modified_base
<222>  (22)..(22)
<223>  2'-O-methyl modified

<220>  
<221>  modified_base
<222>  (23)..(23)
<223>  2'-O-methyl modified

<220>  
<221>  modified_base
<222>  (24)..(24)
<223>  2'-O-methyl modified

<220>  
<221>  modified_base
<222>  (25)..(25)
<223>  2'-O-methyl modified

<220>  
<221>  modified_base
<222>  (26)..(26)
<223>  2'-O-methyl modified

<220>  
<221>  modified_base
<222>  (27)..(27)
<223>  2'-O-methyl modified

<220>  
<221>  modified_base
<222>  (28)..(28)
<223>  GalNAc-conjugated

<220>  
<221>  modified_base
<222>  (29)..(29)
<223>  GalNAc-conjugated

<220>  
<221>  modified_base
<222>  (30)..(30)
<223>  GalNAc-conjugated

<220>  
<221>  modified_base
<222>  (31)..(31)
<223>  2'-O-methyl modified

<220>  
<221>  modified_base
<222>  (32)..(32)
<223>  2'-O-methyl modified

<220>  
<221>  modified_base
<222>  (33)..(33)
<223>  2'-O-methyl modified

<220>  
<221>  modified_base
<222>  (34)..(34)
<223>  2'-O-methyl modified

<220>  
<221>  modified_base
<222>  (35)..(35)
<223>  2'-O-methyl modified

<220>  
<221>  modified_base
<222>  (36)..(36)
<223>  2'-O-methyl modified

<400>  998
gauguuccca cggaugcuaa gcagccgaaa ggcugc                                 36


<210>  999
<211>  36
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  Modified sense strand


<220>
<221>  misc_feature
<222>  (1)..(2)
<223>  linked via phosphorothioate

<220>  
<221>  modified_base
<222>  (1)..(1)
<223>  2'-O-methyl modified

<220>  
<221>  modified_base
<222>  (2)..(2)
<223>  2'-O-methyl modified

<220>  
<221>  modified_base
<222>  (3)..(3)
<223>  2'-O-methyl modified

<220>  
<221>  modified_base
<222>  (4)..(4)
<223>  2'-O-methyl modified

<220>  
<221>  modified_base
<222>  (5)..(5)
<223>  2'-O-methyl modified

<220>  
<221>  modified_base
<222>  (6)..(6)
<223>  2'-O-methyl modified

<220>  
<221>  modified_base
<222>  (7)..(7)
<223>  2'-O-methyl modified

<220>  
<221>  modified_base
<222>  (8)..(8)
<223>  2'-fluoro modified

<220>  
<221>  modified_base
<222>  (9)..(9)
<223>  2'-fluoro modified

<220>  
<221>  modified_base
<222>  (10)..(10)
<223>  2'-fluoro modified

<220>  
<221>  modified_base
<222>  (11)..(11)
<223>  2'-fluoro modified

<220>  
<221>  modified_base
<222>  (12)..(12)
<223>  2'-O-methyl modified

<220>  
<221>  modified_base
<222>  (13)..(13)
<223>  2'-O-methyl modified

<220>  
<221>  modified_base
<222>  (14)..(14)
<223>  2'-O-methyl modified

<220>  
<221>  modified_base
<222>  (15)..(15)
<223>  2'-O-methyl modified

<220>  
<221>  modified_base
<222>  (16)..(16)
<223>  2'-O-methyl modified

<220>  
<221>  modified_base
<222>  (17)..(17)
<223>  2'-O-methyl modified

<220>  
<221>  modified_base
<222>  (18)..(18)
<223>  2'-O-methyl modified

<220>  
<221>  modified_base
<222>  (19)..(19)
<223>  2'-O-methyl modified

<220>  
<221>  modified_base
<222>  (20)..(20)
<223>  2'-O-methyl modified

<220>  
<221>  modified_base
<222>  (21)..(21)
<223>  2'-O-methyl modified

<220>  
<221>  modified_base
<222>  (22)..(22)
<223>  2'-O-methyl modified

<220>  
<221>  modified_base
<222>  (23)..(23)
<223>  2'-O-methyl modified

<220>  
<221>  modified_base
<222>  (24)..(24)
<223>  2'-O-methyl modified

<220>  
<221>  modified_base
<222>  (25)..(25)
<223>  2'-O-methyl modified

<220>  
<221>  modified_base
<222>  (26)..(26)
<223>  2'-O-methyl modified

<220>  
<221>  modified_base
<222>  (27)..(27)
<223>  2'-O-methyl modified

<220>  
<221>  modified_base
<222>  (28)..(28)
<223>  GalNAc-conjugated

<220>  
<221>  modified_base
<222>  (29)..(29)
<223>  GalNAc-conjugated

<220>  
<221>  modified_base
<222>  (30)..(30)
<223>  GalNAc-conjugated

<220>  
<221>  modified_base
<222>  (31)..(31)
<223>  2'-O-methyl modified

<220>  
<221>  modified_base
<222>  (32)..(32)
<223>  2'-O-methyl modified

<220>  
<221>  modified_base
<222>  (33)..(33)
<223>  2'-O-methyl modified

<220>  
<221>  modified_base
<222>  (34)..(34)
<223>  2'-O-methyl modified

<220>  
<221>  modified_base
<222>  (35)..(35)
<223>  2'-O-methyl modified

<220>  
<221>  modified_base
<222>  (36)..(36)
<223>  2'-O-methyl modified

<400>  999
auguucccac ggaugcuaaa gcagccgaaa ggcugc                                 36


<210>  1000
<211>  36
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  Modified sense strand


<220>
<221>  misc_feature
<222>  (1)..(2)
<223>  linked via phosphorothioate

<220>  
<221>  modified_base
<222>  (1)..(1)
<223>  2'-O-methyl modified

<220>  
<221>  modified_base
<222>  (2)..(2)
<223>  2'-O-methyl modified

<220>  
<221>  modified_base
<222>  (3)..(3)
<223>  2'-O-methyl modified

<220>  
<221>  modified_base
<222>  (4)..(4)
<223>  2'-O-methyl modified

<220>  
<221>  modified_base
<222>  (5)..(5)
<223>  2'-O-methyl modified

<220>  
<221>  modified_base
<222>  (6)..(6)
<223>  2'-O-methyl modified

<220>  
<221>  modified_base
<222>  (7)..(7)
<223>  2'-O-methyl modified

<220>  
<221>  modified_base
<222>  (8)..(8)
<223>  2'-fluoro modified

<220>  
<221>  modified_base
<222>  (9)..(9)
<223>  2'-fluoro modified

<220>  
<221>  modified_base
<222>  (10)..(10)
<223>  2'-fluoro modified

<220>  
<221>  modified_base
<222>  (11)..(11)
<223>  2'-fluoro modified

<220>  
<221>  modified_base
<222>  (12)..(12)
<223>  2'-O-methyl modified

<220>  
<221>  modified_base
<222>  (13)..(13)
<223>  2'-O-methyl modified

<220>  
<221>  modified_base
<222>  (14)..(14)
<223>  2'-O-methyl modified

<220>  
<221>  modified_base
<222>  (15)..(15)
<223>  2'-O-methyl modified

<220>  
<221>  modified_base
<222>  (16)..(16)
<223>  2'-O-methyl modified

<220>  
<221>  modified_base
<222>  (17)..(17)
<223>  2'-O-methyl modified

<220>  
<221>  modified_base
<222>  (18)..(18)
<223>  2'-O-methyl modified

<220>  
<221>  modified_base
<222>  (19)..(19)
<223>  2'-O-methyl modified

<220>  
<221>  modified_base
<222>  (20)..(20)
<223>  2'-O-methyl modified

<220>  
<221>  modified_base
<222>  (21)..(21)
<223>  2'-O-methyl modified

<220>  
<221>  modified_base
<222>  (22)..(22)
<223>  2'-O-methyl modified

<220>  
<221>  modified_base
<222>  (23)..(23)
<223>  2'-O-methyl modified

<220>  
<221>  modified_base
<222>  (24)..(24)
<223>  2'-O-methyl modified

<220>  
<221>  modified_base
<222>  (25)..(25)
<223>  2'-O-methyl modified

<220>  
<221>  modified_base
<222>  (26)..(26)
<223>  2'-O-methyl modified

<220>  
<221>  modified_base
<222>  (27)..(27)
<223>  2'-O-methyl modified

<220>  
<221>  modified_base
<222>  (28)..(28)
<223>  GalNAc-conjugated

<220>  
<221>  modified_base
<222>  (29)..(29)
<223>  GalNAc-conjugated

<220>  
<221>  modified_base
<222>  (30)..(30)
<223>  GalNAc-conjugated

<220>  
<221>  modified_base
<222>  (31)..(31)
<223>  2'-O-methyl modified

<220>  
<221>  modified_base
<222>  (32)..(32)
<223>  2'-O-methyl modified

<220>  
<221>  modified_base
<222>  (33)..(33)
<223>  2'-O-methyl modified

<220>  
<221>  modified_base
<222>  (34)..(34)
<223>  2'-O-methyl modified

<220>  
<221>  modified_base
<222>  (35)..(35)
<223>  2'-O-methyl modified

<220>  
<221>  modified_base
<222>  (36)..(36)
<223>  2'-O-methyl modified

<400>  1000
cccacggaug cuaaugaaaa gcagccgaaa ggcugc                                 36


<210>  1001
<211>  36
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  Modified sense strand


<220>
<221>  misc_feature
<222>  (1)..(2)
<223>  linked via phosphorothioate

<220>  
<221>  modified_base
<222>  (1)..(1)
<223>  2'-O-methyl modified

<220>  
<221>  modified_base
<222>  (2)..(2)
<223>  2'-O-methyl modified

<220>  
<221>  modified_base
<222>  (3)..(3)
<223>  2'-O-methyl modified

<220>  
<221>  modified_base
<222>  (4)..(4)
<223>  2'-O-methyl modified

<220>  
<221>  modified_base
<222>  (5)..(5)
<223>  2'-O-methyl modified

<220>  
<221>  modified_base
<222>  (6)..(6)
<223>  2'-O-methyl modified

<220>  
<221>  modified_base
<222>  (7)..(7)
<223>  2'-O-methyl modified

<220>  
<221>  modified_base
<222>  (8)..(8)
<223>  2'-fluoro modified

<220>  
<221>  modified_base
<222>  (9)..(9)
<223>  2'-fluoro modified

<220>  
<221>  modified_base
<222>  (10)..(10)
<223>  2'-fluoro modified

<220>  
<221>  modified_base
<222>  (11)..(11)
<223>  2'-fluoro modified

<220>  
<221>  modified_base
<222>  (12)..(12)
<223>  2'-O-methyl modified

<220>  
<221>  modified_base
<222>  (13)..(13)
<223>  2'-O-methyl modified

<220>  
<221>  modified_base
<222>  (14)..(14)
<223>  2'-O-methyl modified

<220>  
<221>  modified_base
<222>  (15)..(15)
<223>  2'-O-methyl modified

<220>  
<221>  modified_base
<222>  (16)..(16)
<223>  2'-O-methyl modified

<220>  
<221>  modified_base
<222>  (17)..(17)
<223>  2'-O-methyl modified

<220>  
<221>  modified_base
<222>  (18)..(18)
<223>  2'-O-methyl modified

<220>  
<221>  modified_base
<222>  (19)..(19)
<223>  2'-O-methyl modified

<220>  
<221>  modified_base
<222>  (20)..(20)
<223>  2'-O-methyl modified

<220>  
<221>  modified_base
<222>  (21)..(21)
<223>  2'-O-methyl modified

<220>  
<221>  modified_base
<222>  (22)..(22)
<223>  2'-O-methyl modified

<220>  
<221>  modified_base
<222>  (23)..(23)
<223>  2'-O-methyl modified

<220>  
<221>  modified_base
<222>  (24)..(24)
<223>  2'-O-methyl modified

<220>  
<221>  modified_base
<222>  (25)..(25)
<223>  2'-O-methyl modified

<220>  
<221>  modified_base
<222>  (26)..(26)
<223>  2'-O-methyl modified

<220>  
<221>  modified_base
<222>  (27)..(27)
<223>  2'-O-methyl modified

<220>  
<221>  modified_base
<222>  (28)..(28)
<223>  GalNAc-conjugated

<220>  
<221>  modified_base
<222>  (29)..(29)
<223>  GalNAc-conjugated

<220>  
<221>  modified_base
<222>  (30)..(30)
<223>  GalNAc-conjugated

<220>  
<221>  modified_base
<222>  (31)..(31)
<223>  2'-O-methyl modified

<220>  
<221>  modified_base
<222>  (32)..(32)
<223>  2'-O-methyl modified

<220>  
<221>  modified_base
<222>  (33)..(33)
<223>  2'-O-methyl modified

<220>  
<221>  modified_base
<222>  (34)..(34)
<223>  2'-O-methyl modified

<220>  
<221>  modified_base
<222>  (35)..(35)
<223>  2'-O-methyl modified

<220>  
<221>  modified_base
<222>  (36)..(36)
<223>  2'-O-methyl modified

<400>  1001
cggaugcuaa ugaaacugga gcagccgaaa ggcugc                                 36


<210>  1002
<211>  36
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  Modified sense strand


<220>
<221>  misc_feature
<222>  (1)..(2)
<223>  linked via phosphorothioate

<220>  
<221>  modified_base
<222>  (1)..(1)
<223>  2'-O-methyl modified

<220>  
<221>  modified_base
<222>  (2)..(2)
<223>  2'-O-methyl modified

<220>  
<221>  modified_base
<222>  (3)..(3)
<223>  2'-O-methyl modified

<220>  
<221>  modified_base
<222>  (4)..(4)
<223>  2'-O-methyl modified

<220>  
<221>  modified_base
<222>  (5)..(5)
<223>  2'-O-methyl modified

<220>  
<221>  modified_base
<222>  (6)..(6)
<223>  2'-O-methyl modified

<220>  
<221>  modified_base
<222>  (7)..(7)
<223>  2'-O-methyl modified

<220>  
<221>  modified_base
<222>  (8)..(8)
<223>  2'-fluoro modified

<220>  
<221>  modified_base
<222>  (9)..(9)
<223>  2'-fluoro modified

<220>  
<221>  modified_base
<222>  (10)..(10)
<223>  2'-fluoro modified

<220>  
<221>  modified_base
<222>  (11)..(11)
<223>  2'-fluoro modified

<220>  
<221>  modified_base
<222>  (12)..(12)
<223>  2'-O-methyl modified

<220>  
<221>  modified_base
<222>  (13)..(13)
<223>  2'-O-methyl modified

<220>  
<221>  modified_base
<222>  (14)..(14)
<223>  2'-O-methyl modified

<220>  
<221>  modified_base
<222>  (15)..(15)
<223>  2'-O-methyl modified

<220>  
<221>  modified_base
<222>  (16)..(16)
<223>  2'-O-methyl modified

<220>  
<221>  modified_base
<222>  (17)..(17)
<223>  2'-O-methyl modified

<220>  
<221>  modified_base
<222>  (18)..(18)
<223>  2'-O-methyl modified

<220>  
<221>  modified_base
<222>  (19)..(19)
<223>  2'-O-methyl modified

<220>  
<221>  modified_base
<222>  (20)..(20)
<223>  2'-O-methyl modified

<220>  
<221>  modified_base
<222>  (21)..(21)
<223>  2'-O-methyl modified

<220>  
<221>  modified_base
<222>  (22)..(22)
<223>  2'-O-methyl modified

<220>  
<221>  modified_base
<222>  (23)..(23)
<223>  2'-O-methyl modified

<220>  
<221>  modified_base
<222>  (24)..(24)
<223>  2'-O-methyl modified

<220>  
<221>  modified_base
<222>  (25)..(25)
<223>  2'-O-methyl modified

<220>  
<221>  modified_base
<222>  (26)..(26)
<223>  2'-O-methyl modified

<220>  
<221>  modified_base
<222>  (27)..(27)
<223>  2'-O-methyl modified

<220>  
<221>  modified_base
<222>  (28)..(28)
<223>  GalNAc-conjugated

<220>  
<221>  modified_base
<222>  (29)..(29)
<223>  GalNAc-conjugated

<220>  
<221>  modified_base
<222>  (30)..(30)
<223>  GalNAc-conjugated

<220>  
<221>  modified_base
<222>  (31)..(31)
<223>  2'-O-methyl modified

<220>  
<221>  modified_base
<222>  (32)..(32)
<223>  2'-O-methyl modified

<220>  
<221>  modified_base
<222>  (33)..(33)
<223>  2'-O-methyl modified

<220>  
<221>  modified_base
<222>  (34)..(34)
<223>  2'-O-methyl modified

<220>  
<221>  modified_base
<222>  (35)..(35)
<223>  2'-O-methyl modified

<220>  
<221>  modified_base
<222>  (36)..(36)
<223>  2'-O-methyl modified

<400>  1002
ggaugcuaau gaaacuggua gcagccgaaa ggcugc                                 36


<210>  1003
<211>  36
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  Modified sense strand


<220>
<221>  misc_feature
<222>  (1)..(2)
<223>  linked via phosphorothioate

<220>  
<221>  modified_base
<222>  (1)..(1)
<223>  2'-O-methyl modified

<220>  
<221>  modified_base
<222>  (2)..(2)
<223>  2'-O-methyl modified

<220>  
<221>  modified_base
<222>  (3)..(3)
<223>  2'-O-methyl modified

<220>  
<221>  modified_base
<222>  (4)..(4)
<223>  2'-O-methyl modified

<220>  
<221>  modified_base
<222>  (5)..(5)
<223>  2'-O-methyl modified

<220>  
<221>  modified_base
<222>  (6)..(6)
<223>  2'-O-methyl modified

<220>  
<221>  modified_base
<222>  (7)..(7)
<223>  2'-O-methyl modified

<220>  
<221>  modified_base
<222>  (8)..(8)
<223>  2'-fluoro modified

<220>  
<221>  modified_base
<222>  (9)..(9)
<223>  2'-fluoro modified

<220>  
<221>  modified_base
<222>  (10)..(10)
<223>  2'-fluoro modified

<220>  
<221>  modified_base
<222>  (11)..(11)
<223>  2'-fluoro modified

<220>  
<221>  modified_base
<222>  (12)..(12)
<223>  2'-O-methyl modified

<220>  
<221>  modified_base
<222>  (13)..(13)
<223>  2'-O-methyl modified

<220>  
<221>  modified_base
<222>  (14)..(14)
<223>  2'-O-methyl modified

<220>  
<221>  modified_base
<222>  (15)..(15)
<223>  2'-O-methyl modified

<220>  
<221>  modified_base
<222>  (16)..(16)
<223>  2'-O-methyl modified

<220>  
<221>  modified_base
<222>  (17)..(17)
<223>  2'-O-methyl modified

<220>  
<221>  modified_base
<222>  (18)..(18)
<223>  2'-O-methyl modified

<220>  
<221>  modified_base
<222>  (19)..(19)
<223>  2'-O-methyl modified

<220>  
<221>  modified_base
<222>  (20)..(20)
<223>  2'-O-methyl modified

<220>  
<221>  modified_base
<222>  (21)..(21)
<223>  2'-O-methyl modified

<220>  
<221>  modified_base
<222>  (22)..(22)
<223>  2'-O-methyl modified

<220>  
<221>  modified_base
<222>  (23)..(23)
<223>  2'-O-methyl modified

<220>  
<221>  modified_base
<222>  (24)..(24)
<223>  2'-O-methyl modified

<220>  
<221>  modified_base
<222>  (25)..(25)
<223>  2'-O-methyl modified

<220>  
<221>  modified_base
<222>  (26)..(26)
<223>  2'-O-methyl modified

<220>  
<221>  modified_base
<222>  (27)..(27)
<223>  2'-O-methyl modified

<220>  
<221>  modified_base
<222>  (28)..(28)
<223>  GalNAc-conjugated

<220>  
<221>  modified_base
<222>  (29)..(29)
<223>  GalNAc-conjugated

<220>  
<221>  modified_base
<222>  (30)..(30)
<223>  GalNAc-conjugated

<220>  
<221>  modified_base
<222>  (31)..(31)
<223>  2'-O-methyl modified

<220>  
<221>  modified_base
<222>  (32)..(32)
<223>  2'-O-methyl modified

<220>  
<221>  modified_base
<222>  (33)..(33)
<223>  2'-O-methyl modified

<220>  
<221>  modified_base
<222>  (34)..(34)
<223>  2'-O-methyl modified

<220>  
<221>  modified_base
<222>  (35)..(35)
<223>  2'-O-methyl modified

<220>  
<221>  modified_base
<222>  (36)..(36)
<223>  2'-O-methyl modified

<400>  1003
gaugcuaaug aaacugguga gcagccgaaa ggcugc                                 36


<210>  1004
<211>  36
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  Modified sense strand


<220>
<221>  misc_feature
<222>  (1)..(2)
<223>  linked via phosphorothioate

<220>  
<221>  modified_base
<222>  (1)..(1)
<223>  2'-O-methyl modified

<220>  
<221>  modified_base
<222>  (2)..(2)
<223>  2'-O-methyl modified

<220>  
<221>  modified_base
<222>  (3)..(3)
<223>  2'-O-methyl modified

<220>  
<221>  modified_base
<222>  (4)..(4)
<223>  2'-O-methyl modified

<220>  
<221>  modified_base
<222>  (5)..(5)
<223>  2'-O-methyl modified

<220>  
<221>  modified_base
<222>  (6)..(6)
<223>  2'-O-methyl modified

<220>  
<221>  modified_base
<222>  (7)..(7)
<223>  2'-O-methyl modified

<220>  
<221>  modified_base
<222>  (8)..(8)
<223>  2'-fluoro modified

<220>  
<221>  modified_base
<222>  (9)..(9)
<223>  2'-fluoro modified

<220>  
<221>  modified_base
<222>  (10)..(10)
<223>  2'-fluoro modified

<220>  
<221>  modified_base
<222>  (11)..(11)
<223>  2'-fluoro modified

<220>  
<221>  modified_base
<222>  (12)..(12)
<223>  2'-O-methyl modified

<220>  
<221>  modified_base
<222>  (13)..(13)
<223>  2'-O-methyl modified

<220>  
<221>  modified_base
<222>  (14)..(14)
<223>  2'-O-methyl modified

<220>  
<221>  modified_base
<222>  (15)..(15)
<223>  2'-O-methyl modified

<220>  
<221>  modified_base
<222>  (16)..(16)
<223>  2'-O-methyl modified

<220>  
<221>  modified_base
<222>  (17)..(17)
<223>  2'-O-methyl modified

<220>  
<221>  modified_base
<222>  (18)..(18)
<223>  2'-O-methyl modified

<220>  
<221>  modified_base
<222>  (19)..(19)
<223>  2'-O-methyl modified

<220>  
<221>  modified_base
<222>  (20)..(20)
<223>  2'-O-methyl modified

<220>  
<221>  modified_base
<222>  (21)..(21)
<223>  2'-O-methyl modified

<220>  
<221>  modified_base
<222>  (22)..(22)
<223>  2'-O-methyl modified

<220>  
<221>  modified_base
<222>  (23)..(23)
<223>  2'-O-methyl modified

<220>  
<221>  modified_base
<222>  (24)..(24)
<223>  2'-O-methyl modified

<220>  
<221>  modified_base
<222>  (25)..(25)
<223>  2'-O-methyl modified

<220>  
<221>  modified_base
<222>  (26)..(26)
<223>  2'-O-methyl modified

<220>  
<221>  modified_base
<222>  (27)..(27)
<223>  2'-O-methyl modified

<220>  
<221>  modified_base
<222>  (28)..(28)
<223>  GalNAc-conjugated

<220>  
<221>  modified_base
<222>  (29)..(29)
<223>  GalNAc-conjugated

<220>  
<221>  modified_base
<222>  (30)..(30)
<223>  GalNAc-conjugated

<220>  
<221>  modified_base
<222>  (31)..(31)
<223>  2'-O-methyl modified

<220>  
<221>  modified_base
<222>  (32)..(32)
<223>  2'-O-methyl modified

<220>  
<221>  modified_base
<222>  (33)..(33)
<223>  2'-O-methyl modified

<220>  
<221>  modified_base
<222>  (34)..(34)
<223>  2'-O-methyl modified

<220>  
<221>  modified_base
<222>  (35)..(35)
<223>  2'-O-methyl modified

<220>  
<221>  modified_base
<222>  (36)..(36)
<223>  2'-O-methyl modified

<400>  1004
augcuaauga aacuggugaa gcagccgaaa ggcugc                                 36


<210>  1005
<211>  36
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  Modified sense strand


<220>
<221>  misc_feature
<222>  (1)..(2)
<223>  linked via phosphorothioate

<220>  
<221>  modified_base
<222>  (1)..(1)
<223>  2'-O-methyl modified

<220>  
<221>  modified_base
<222>  (2)..(2)
<223>  2'-O-methyl modified

<220>  
<221>  modified_base
<222>  (3)..(3)
<223>  2'-O-methyl modified

<220>  
<221>  modified_base
<222>  (4)..(4)
<223>  2'-O-methyl modified

<220>  
<221>  modified_base
<222>  (5)..(5)
<223>  2'-O-methyl modified

<220>  
<221>  modified_base
<222>  (6)..(6)
<223>  2'-O-methyl modified

<220>  
<221>  modified_base
<222>  (7)..(7)
<223>  2'-O-methyl modified

<220>  
<221>  modified_base
<222>  (8)..(8)
<223>  2'-fluoro modified

<220>  
<221>  modified_base
<222>  (9)..(9)
<223>  2'-fluoro modified

<220>  
<221>  modified_base
<222>  (10)..(10)
<223>  2'-fluoro modified

<220>  
<221>  modified_base
<222>  (11)..(11)
<223>  2'-fluoro modified

<220>  
<221>  modified_base
<222>  (12)..(12)
<223>  2'-O-methyl modified

<220>  
<221>  modified_base
<222>  (13)..(13)
<223>  2'-O-methyl modified

<220>  
<221>  modified_base
<222>  (14)..(14)
<223>  2'-O-methyl modified

<220>  
<221>  modified_base
<222>  (15)..(15)
<223>  2'-O-methyl modified

<220>  
<221>  modified_base
<222>  (16)..(16)
<223>  2'-O-methyl modified

<220>  
<221>  modified_base
<222>  (17)..(17)
<223>  2'-O-methyl modified

<220>  
<221>  modified_base
<222>  (18)..(18)
<223>  2'-O-methyl modified

<220>  
<221>  modified_base
<222>  (19)..(19)
<223>  2'-O-methyl modified

<220>  
<221>  modified_base
<222>  (20)..(20)
<223>  2'-O-methyl modified

<220>  
<221>  modified_base
<222>  (21)..(21)
<223>  2'-O-methyl modified

<220>  
<221>  modified_base
<222>  (22)..(22)
<223>  2'-O-methyl modified

<220>  
<221>  modified_base
<222>  (23)..(23)
<223>  2'-O-methyl modified

<220>  
<221>  modified_base
<222>  (24)..(24)
<223>  2'-O-methyl modified

<220>  
<221>  modified_base
<222>  (25)..(25)
<223>  2'-O-methyl modified

<220>  
<221>  modified_base
<222>  (26)..(26)
<223>  2'-O-methyl modified

<220>  
<221>  modified_base
<222>  (27)..(27)
<223>  2'-O-methyl modified

<220>  
<221>  modified_base
<222>  (28)..(28)
<223>  GalNAc-conjugated

<220>  
<221>  modified_base
<222>  (29)..(29)
<223>  GalNAc-conjugated

<220>  
<221>  modified_base
<222>  (30)..(30)
<223>  GalNAc-conjugated

<220>  
<221>  modified_base
<222>  (31)..(31)
<223>  2'-O-methyl modified

<220>  
<221>  modified_base
<222>  (32)..(32)
<223>  2'-O-methyl modified

<220>  
<221>  modified_base
<222>  (33)..(33)
<223>  2'-O-methyl modified

<220>  
<221>  modified_base
<222>  (34)..(34)
<223>  2'-O-methyl modified

<220>  
<221>  modified_base
<222>  (35)..(35)
<223>  2'-O-methyl modified

<220>  
<221>  modified_base
<222>  (36)..(36)
<223>  2'-O-methyl modified

<400>  1005
cuaaugaaac uggugagcca gcagccgaaa ggcugc                                 36


<210>  1006
<211>  36
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  Modified sense strand


<220>
<221>  misc_feature
<222>  (1)..(2)
<223>  linked via phosphorothioate

<220>  
<221>  modified_base
<222>  (1)..(1)
<223>  2'-O-methyl modified

<220>  
<221>  modified_base
<222>  (2)..(2)
<223>  2'-O-methyl modified

<220>  
<221>  modified_base
<222>  (3)..(3)
<223>  2'-O-methyl modified

<220>  
<221>  modified_base
<222>  (4)..(4)
<223>  2'-O-methyl modified

<220>  
<221>  modified_base
<222>  (5)..(5)
<223>  2'-O-methyl modified

<220>  
<221>  modified_base
<222>  (6)..(6)
<223>  2'-O-methyl modified

<220>  
<221>  modified_base
<222>  (7)..(7)
<223>  2'-O-methyl modified

<220>  
<221>  modified_base
<222>  (8)..(8)
<223>  2'-fluoro modified

<220>  
<221>  modified_base
<222>  (9)..(9)
<223>  2'-fluoro modified

<220>  
<221>  modified_base
<222>  (10)..(10)
<223>  2'-fluoro modified

<220>  
<221>  modified_base
<222>  (11)..(11)
<223>  2'-fluoro modified

<220>  
<221>  modified_base
<222>  (12)..(12)
<223>  2'-O-methyl modified

<220>  
<221>  modified_base
<222>  (13)..(13)
<223>  2'-O-methyl modified

<220>  
<221>  modified_base
<222>  (14)..(14)
<223>  2'-O-methyl modified

<220>  
<221>  modified_base
<222>  (15)..(15)
<223>  2'-O-methyl modified

<220>  
<221>  modified_base
<222>  (16)..(16)
<223>  2'-O-methyl modified

<220>  
<221>  modified_base
<222>  (17)..(17)
<223>  2'-O-methyl modified

<220>  
<221>  modified_base
<222>  (18)..(18)
<223>  2'-O-methyl modified

<220>  
<221>  modified_base
<222>  (19)..(19)
<223>  2'-O-methyl modified

<220>  
<221>  modified_base
<222>  (20)..(20)
<223>  2'-O-methyl modified

<220>  
<221>  modified_base
<222>  (21)..(21)
<223>  2'-O-methyl modified

<220>  
<221>  modified_base
<222>  (22)..(22)
<223>  2'-O-methyl modified

<220>  
<221>  modified_base
<222>  (23)..(23)
<223>  2'-O-methyl modified

<220>  
<221>  modified_base
<222>  (24)..(24)
<223>  2'-O-methyl modified

<220>  
<221>  modified_base
<222>  (25)..(25)
<223>  2'-O-methyl modified

<220>  
<221>  modified_base
<222>  (26)..(26)
<223>  2'-O-methyl modified

<220>  
<221>  modified_base
<222>  (27)..(27)
<223>  2'-O-methyl modified

<220>  
<221>  modified_base
<222>  (28)..(28)
<223>  GalNAc-conjugated

<220>  
<221>  modified_base
<222>  (29)..(29)
<223>  GalNAc-conjugated

<220>  
<221>  modified_base
<222>  (30)..(30)
<223>  GalNAc-conjugated

<220>  
<221>  modified_base
<222>  (31)..(31)
<223>  2'-O-methyl modified

<220>  
<221>  modified_base
<222>  (32)..(32)
<223>  2'-O-methyl modified

<220>  
<221>  modified_base
<222>  (33)..(33)
<223>  2'-O-methyl modified

<220>  
<221>  modified_base
<222>  (34)..(34)
<223>  2'-O-methyl modified

<220>  
<221>  modified_base
<222>  (35)..(35)
<223>  2'-O-methyl modified

<220>  
<221>  modified_base
<222>  (36)..(36)
<223>  2'-O-methyl modified

<400>  1006
agcagcgucc acucagagca gcagccgaaa ggcugc                                 36


<210>  1007
<211>  36
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  Modified sense strand


<220>
<221>  misc_feature
<222>  (1)..(2)
<223>  linked via phosphorothioate

<220>  
<221>  modified_base
<222>  (1)..(1)
<223>  2'-O-methyl modified

<220>  
<221>  modified_base
<222>  (2)..(2)
<223>  2'-O-methyl modified

<220>  
<221>  modified_base
<222>  (3)..(3)
<223>  2'-O-methyl modified

<220>  
<221>  modified_base
<222>  (4)..(4)
<223>  2'-O-methyl modified

<220>  
<221>  modified_base
<222>  (5)..(5)
<223>  2'-O-methyl modified

<220>  
<221>  modified_base
<222>  (6)..(6)
<223>  2'-O-methyl modified

<220>  
<221>  modified_base
<222>  (7)..(7)
<223>  2'-O-methyl modified

<220>  
<221>  modified_base
<222>  (8)..(8)
<223>  2'-fluoro modified

<220>  
<221>  modified_base
<222>  (9)..(9)
<223>  2'-fluoro modified

<220>  
<221>  modified_base
<222>  (10)..(10)
<223>  2'-fluoro modified

<220>  
<221>  modified_base
<222>  (11)..(11)
<223>  2'-fluoro modified

<220>  
<221>  modified_base
<222>  (12)..(12)
<223>  2'-O-methyl modified

<220>  
<221>  modified_base
<222>  (13)..(13)
<223>  2'-O-methyl modified

<220>  
<221>  modified_base
<222>  (14)..(14)
<223>  2'-O-methyl modified

<220>  
<221>  modified_base
<222>  (15)..(15)
<223>  2'-O-methyl modified

<220>  
<221>  modified_base
<222>  (16)..(16)
<223>  2'-O-methyl modified

<220>  
<221>  modified_base
<222>  (17)..(17)
<223>  2'-O-methyl modified

<220>  
<221>  modified_base
<222>  (18)..(18)
<223>  2'-O-methyl modified

<220>  
<221>  modified_base
<222>  (19)..(19)
<223>  2'-O-methyl modified

<220>  
<221>  modified_base
<222>  (20)..(20)
<223>  2'-O-methyl modified

<220>  
<221>  modified_base
<222>  (21)..(21)
<223>  2'-O-methyl modified

<220>  
<221>  modified_base
<222>  (22)..(22)
<223>  2'-O-methyl modified

<220>  
<221>  modified_base
<222>  (23)..(23)
<223>  2'-O-methyl modified

<220>  
<221>  modified_base
<222>  (24)..(24)
<223>  2'-O-methyl modified

<220>  
<221>  modified_base
<222>  (25)..(25)
<223>  2'-O-methyl modified

<220>  
<221>  modified_base
<222>  (26)..(26)
<223>  2'-O-methyl modified

<220>  
<221>  modified_base
<222>  (27)..(27)
<223>  2'-O-methyl modified

<220>  
<221>  modified_base
<222>  (28)..(28)
<223>  GalNAc-conjugated

<220>  
<221>  modified_base
<222>  (29)..(29)
<223>  GalNAc-conjugated

<220>  
<221>  modified_base
<222>  (30)..(30)
<223>  GalNAc-conjugated

<220>  
<221>  modified_base
<222>  (31)..(31)
<223>  2'-O-methyl modified

<220>  
<221>  modified_base
<222>  (32)..(32)
<223>  2'-O-methyl modified

<220>  
<221>  modified_base
<222>  (33)..(33)
<223>  2'-O-methyl modified

<220>  
<221>  modified_base
<222>  (34)..(34)
<223>  2'-O-methyl modified

<220>  
<221>  modified_base
<222>  (35)..(35)
<223>  2'-O-methyl modified

<220>  
<221>  modified_base
<222>  (36)..(36)
<223>  2'-O-methyl modified

<400>  1007
cagcguccac ucagagcaaa gcagccgaaa ggcugc                                 36


<210>  1008
<211>  36
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  Modified sense strand


<220>
<221>  misc_feature
<222>  (1)..(2)
<223>  linked via phosphorothioate

<220>  
<221>  modified_base
<222>  (1)..(1)
<223>  2'-O-methyl modified

<220>  
<221>  modified_base
<222>  (2)..(2)
<223>  2'-O-methyl modified

<220>  
<221>  modified_base
<222>  (3)..(3)
<223>  2'-O-methyl modified

<220>  
<221>  modified_base
<222>  (4)..(4)
<223>  2'-O-methyl modified

<220>  
<221>  modified_base
<222>  (5)..(5)
<223>  2'-O-methyl modified

<220>  
<221>  modified_base
<222>  (6)..(6)
<223>  2'-O-methyl modified

<220>  
<221>  modified_base
<222>  (7)..(7)
<223>  2'-O-methyl modified

<220>  
<221>  modified_base
<222>  (8)..(8)
<223>  2'-fluoro modified

<220>  
<221>  modified_base
<222>  (9)..(9)
<223>  2'-fluoro modified

<220>  
<221>  modified_base
<222>  (10)..(10)
<223>  2'-fluoro modified

<220>  
<221>  modified_base
<222>  (11)..(11)
<223>  2'-fluoro modified

<220>  
<221>  modified_base
<222>  (12)..(12)
<223>  2'-O-methyl modified

<220>  
<221>  modified_base
<222>  (13)..(13)
<223>  2'-O-methyl modified

<220>  
<221>  modified_base
<222>  (14)..(14)
<223>  2'-O-methyl modified

<220>  
<221>  modified_base
<222>  (15)..(15)
<223>  2'-O-methyl modified

<220>  
<221>  modified_base
<222>  (16)..(16)
<223>  2'-O-methyl modified

<220>  
<221>  modified_base
<222>  (17)..(17)
<223>  2'-O-methyl modified

<220>  
<221>  modified_base
<222>  (18)..(18)
<223>  2'-O-methyl modified

<220>  
<221>  modified_base
<222>  (19)..(19)
<223>  2'-O-methyl modified

<220>  
<221>  modified_base
<222>  (20)..(20)
<223>  2'-O-methyl modified

<220>  
<221>  modified_base
<222>  (21)..(21)
<223>  2'-O-methyl modified

<220>  
<221>  modified_base
<222>  (22)..(22)
<223>  2'-O-methyl modified

<220>  
<221>  modified_base
<222>  (23)..(23)
<223>  2'-O-methyl modified

<220>  
<221>  modified_base
<222>  (24)..(24)
<223>  2'-O-methyl modified

<220>  
<221>  modified_base
<222>  (25)..(25)
<223>  2'-O-methyl modified

<220>  
<221>  modified_base
<222>  (26)..(26)
<223>  2'-O-methyl modified

<220>  
<221>  modified_base
<222>  (27)..(27)
<223>  2'-O-methyl modified

<220>  
<221>  modified_base
<222>  (28)..(28)
<223>  GalNAc-conjugated

<220>  
<221>  modified_base
<222>  (29)..(29)
<223>  GalNAc-conjugated

<220>  
<221>  modified_base
<222>  (30)..(30)
<223>  GalNAc-conjugated

<220>  
<221>  modified_base
<222>  (31)..(31)
<223>  2'-O-methyl modified

<220>  
<221>  modified_base
<222>  (32)..(32)
<223>  2'-O-methyl modified

<220>  
<221>  modified_base
<222>  (33)..(33)
<223>  2'-O-methyl modified

<220>  
<221>  modified_base
<222>  (34)..(34)
<223>  2'-O-methyl modified

<220>  
<221>  modified_base
<222>  (35)..(35)
<223>  2'-O-methyl modified

<220>  
<221>  modified_base
<222>  (36)..(36)
<223>  2'-O-methyl modified

<400>  1008
agcguccacu cagagcaaga gcagccgaaa ggcugc                                 36


<210>  1009
<211>  36
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  Modified sense strand


<220>
<221>  misc_feature
<222>  (1)..(2)
<223>  linked via phosphorothioate

<220>  
<221>  modified_base
<222>  (1)..(1)
<223>  2'-O-methyl modified

<220>  
<221>  modified_base
<222>  (2)..(2)
<223>  2'-O-methyl modified

<220>  
<221>  modified_base
<222>  (3)..(3)
<223>  2'-O-methyl modified

<220>  
<221>  modified_base
<222>  (4)..(4)
<223>  2'-O-methyl modified

<220>  
<221>  modified_base
<222>  (5)..(5)
<223>  2'-O-methyl modified

<220>  
<221>  modified_base
<222>  (6)..(6)
<223>  2'-O-methyl modified

<220>  
<221>  modified_base
<222>  (7)..(7)
<223>  2'-O-methyl modified

<220>  
<221>  modified_base
<222>  (8)..(8)
<223>  2'-fluoro modified

<220>  
<221>  modified_base
<222>  (9)..(9)
<223>  2'-fluoro modified

<220>  
<221>  modified_base
<222>  (10)..(10)
<223>  2'-fluoro modified

<220>  
<221>  modified_base
<222>  (11)..(11)
<223>  2'-fluoro modified

<220>  
<221>  modified_base
<222>  (12)..(12)
<223>  2'-O-methyl modified

<220>  
<221>  modified_base
<222>  (13)..(13)
<223>  2'-O-methyl modified

<220>  
<221>  modified_base
<222>  (14)..(14)
<223>  2'-O-methyl modified

<220>  
<221>  modified_base
<222>  (15)..(15)
<223>  2'-O-methyl modified

<220>  
<221>  modified_base
<222>  (16)..(16)
<223>  2'-O-methyl modified

<220>  
<221>  modified_base
<222>  (17)..(17)
<223>  2'-O-methyl modified

<220>  
<221>  modified_base
<222>  (18)..(18)
<223>  2'-O-methyl modified

<220>  
<221>  modified_base
<222>  (19)..(19)
<223>  2'-O-methyl modified

<220>  
<221>  modified_base
<222>  (20)..(20)
<223>  2'-O-methyl modified

<220>  
<221>  modified_base
<222>  (21)..(21)
<223>  2'-O-methyl modified

<220>  
<221>  modified_base
<222>  (22)..(22)
<223>  2'-O-methyl modified

<220>  
<221>  modified_base
<222>  (23)..(23)
<223>  2'-O-methyl modified

<220>  
<221>  modified_base
<222>  (24)..(24)
<223>  2'-O-methyl modified

<220>  
<221>  modified_base
<222>  (25)..(25)
<223>  2'-O-methyl modified

<220>  
<221>  modified_base
<222>  (26)..(26)
<223>  2'-O-methyl modified

<220>  
<221>  modified_base
<222>  (27)..(27)
<223>  2'-O-methyl modified

<220>  
<221>  modified_base
<222>  (28)..(28)
<223>  GalNAc-conjugated

<220>  
<221>  modified_base
<222>  (29)..(29)
<223>  GalNAc-conjugated

<220>  
<221>  modified_base
<222>  (30)..(30)
<223>  GalNAc-conjugated

<220>  
<221>  modified_base
<222>  (31)..(31)
<223>  2'-O-methyl modified

<220>  
<221>  modified_base
<222>  (32)..(32)
<223>  2'-O-methyl modified

<220>  
<221>  modified_base
<222>  (33)..(33)
<223>  2'-O-methyl modified

<220>  
<221>  modified_base
<222>  (34)..(34)
<223>  2'-O-methyl modified

<220>  
<221>  modified_base
<222>  (35)..(35)
<223>  2'-O-methyl modified

<220>  
<221>  modified_base
<222>  (36)..(36)
<223>  2'-O-methyl modified

<400>  1009
cacucagagc aaguguuuga gcagccgaaa ggcugc                                 36


<210>  1010
<211>  36
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  Modified sense strand


<220>
<221>  misc_feature
<222>  (1)..(2)
<223>  linked via phosphorothioate

<220>  
<221>  modified_base
<222>  (1)..(1)
<223>  2'-O-methyl modified

<220>  
<221>  modified_base
<222>  (2)..(2)
<223>  2'-O-methyl modified

<220>  
<221>  modified_base
<222>  (3)..(3)
<223>  2'-O-methyl modified

<220>  
<221>  modified_base
<222>  (4)..(4)
<223>  2'-O-methyl modified

<220>  
<221>  modified_base
<222>  (5)..(5)
<223>  2'-O-methyl modified

<220>  
<221>  modified_base
<222>  (6)..(6)
<223>  2'-O-methyl modified

<220>  
<221>  modified_base
<222>  (7)..(7)
<223>  2'-O-methyl modified

<220>  
<221>  modified_base
<222>  (8)..(8)
<223>  2'-fluoro modified

<220>  
<221>  modified_base
<222>  (9)..(9)
<223>  2'-fluoro modified

<220>  
<221>  modified_base
<222>  (10)..(10)
<223>  2'-fluoro modified

<220>  
<221>  modified_base
<222>  (11)..(11)
<223>  2'-fluoro modified

<220>  
<221>  modified_base
<222>  (12)..(12)
<223>  2'-O-methyl modified

<220>  
<221>  modified_base
<222>  (13)..(13)
<223>  2'-O-methyl modified

<220>  
<221>  modified_base
<222>  (14)..(14)
<223>  2'-O-methyl modified

<220>  
<221>  modified_base
<222>  (15)..(15)
<223>  2'-O-methyl modified

<220>  
<221>  modified_base
<222>  (16)..(16)
<223>  2'-O-methyl modified

<220>  
<221>  modified_base
<222>  (17)..(17)
<223>  2'-O-methyl modified

<220>  
<221>  modified_base
<222>  (18)..(18)
<223>  2'-O-methyl modified

<220>  
<221>  modified_base
<222>  (19)..(19)
<223>  2'-O-methyl modified

<220>  
<221>  modified_base
<222>  (20)..(20)
<223>  2'-O-methyl modified

<220>  
<221>  modified_base
<222>  (21)..(21)
<223>  2'-O-methyl modified

<220>  
<221>  modified_base
<222>  (22)..(22)
<223>  2'-O-methyl modified

<220>  
<221>  modified_base
<222>  (23)..(23)
<223>  2'-O-methyl modified

<220>  
<221>  modified_base
<222>  (24)..(24)
<223>  2'-O-methyl modified

<220>  
<221>  modified_base
<222>  (25)..(25)
<223>  2'-O-methyl modified

<220>  
<221>  modified_base
<222>  (26)..(26)
<223>  2'-O-methyl modified

<220>  
<221>  modified_base
<222>  (27)..(27)
<223>  2'-O-methyl modified

<220>  
<221>  modified_base
<222>  (28)..(28)
<223>  GalNAc-conjugated

<220>  
<221>  modified_base
<222>  (29)..(29)
<223>  GalNAc-conjugated

<220>  
<221>  modified_base
<222>  (30)..(30)
<223>  GalNAc-conjugated

<220>  
<221>  modified_base
<222>  (31)..(31)
<223>  2'-O-methyl modified

<220>  
<221>  modified_base
<222>  (32)..(32)
<223>  2'-O-methyl modified

<220>  
<221>  modified_base
<222>  (33)..(33)
<223>  2'-O-methyl modified

<220>  
<221>  modified_base
<222>  (34)..(34)
<223>  2'-O-methyl modified

<220>  
<221>  modified_base
<222>  (35)..(35)
<223>  2'-O-methyl modified

<220>  
<221>  modified_base
<222>  (36)..(36)
<223>  2'-O-methyl modified

<400>  1010
caaguguuug cacugcguca gcagccgaaa ggcugc                                 36


<210>  1011
<211>  36
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  Modified sense strand


<220>
<221>  misc_feature
<222>  (1)..(2)
<223>  linked via phosphorothioate

<220>  
<221>  modified_base
<222>  (1)..(1)
<223>  2'-O-methyl modified

<220>  
<221>  modified_base
<222>  (2)..(2)
<223>  2'-O-methyl modified

<220>  
<221>  modified_base
<222>  (3)..(3)
<223>  2'-O-methyl modified

<220>  
<221>  modified_base
<222>  (4)..(4)
<223>  2'-O-methyl modified

<220>  
<221>  modified_base
<222>  (5)..(5)
<223>  2'-O-methyl modified

<220>  
<221>  modified_base
<222>  (6)..(6)
<223>  2'-O-methyl modified

<220>  
<221>  modified_base
<222>  (7)..(7)
<223>  2'-O-methyl modified

<220>  
<221>  modified_base
<222>  (8)..(8)
<223>  2'-fluoro modified

<220>  
<221>  modified_base
<222>  (9)..(9)
<223>  2'-fluoro modified

<220>  
<221>  modified_base
<222>  (10)..(10)
<223>  2'-fluoro modified

<220>  
<221>  modified_base
<222>  (11)..(11)
<223>  2'-fluoro modified

<220>  
<221>  modified_base
<222>  (12)..(12)
<223>  2'-O-methyl modified

<220>  
<221>  modified_base
<222>  (13)..(13)
<223>  2'-O-methyl modified

<220>  
<221>  modified_base
<222>  (14)..(14)
<223>  2'-O-methyl modified

<220>  
<221>  modified_base
<222>  (15)..(15)
<223>  2'-O-methyl modified

<220>  
<221>  modified_base
<222>  (16)..(16)
<223>  2'-O-methyl modified

<220>  
<221>  modified_base
<222>  (17)..(17)
<223>  2'-O-methyl modified

<220>  
<221>  modified_base
<222>  (18)..(18)
<223>  2'-O-methyl modified

<220>  
<221>  modified_base
<222>  (19)..(19)
<223>  2'-O-methyl modified

<220>  
<221>  modified_base
<222>  (20)..(20)
<223>  2'-O-methyl modified

<220>  
<221>  modified_base
<222>  (21)..(21)
<223>  2'-O-methyl modified

<220>  
<221>  modified_base
<222>  (22)..(22)
<223>  2'-O-methyl modified

<220>  
<221>  modified_base
<222>  (23)..(23)
<223>  2'-O-methyl modified

<220>  
<221>  modified_base
<222>  (24)..(24)
<223>  2'-O-methyl modified

<220>  
<221>  modified_base
<222>  (25)..(25)
<223>  2'-O-methyl modified

<220>  
<221>  modified_base
<222>  (26)..(26)
<223>  2'-O-methyl modified

<220>  
<221>  modified_base
<222>  (27)..(27)
<223>  2'-O-methyl modified

<220>  
<221>  modified_base
<222>  (28)..(28)
<223>  GalNAc-conjugated

<220>  
<221>  modified_base
<222>  (29)..(29)
<223>  GalNAc-conjugated

<220>  
<221>  modified_base
<222>  (30)..(30)
<223>  GalNAc-conjugated

<220>  
<221>  modified_base
<222>  (31)..(31)
<223>  2'-O-methyl modified

<220>  
<221>  modified_base
<222>  (32)..(32)
<223>  2'-O-methyl modified

<220>  
<221>  modified_base
<222>  (33)..(33)
<223>  2'-O-methyl modified

<220>  
<221>  modified_base
<222>  (34)..(34)
<223>  2'-O-methyl modified

<220>  
<221>  modified_base
<222>  (35)..(35)
<223>  2'-O-methyl modified

<220>  
<221>  modified_base
<222>  (36)..(36)
<223>  2'-O-methyl modified

<400>  1011
aguguuugca cugcgucuga gcagccgaaa ggcugc                                 36


<210>  1012
<211>  36
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  Modified sense strand


<220>
<221>  misc_feature
<222>  (1)..(2)
<223>  linked via phosphorothioate

<220>  
<221>  modified_base
<222>  (1)..(1)
<223>  2'-O-methyl modified

<220>  
<221>  modified_base
<222>  (2)..(2)
<223>  2'-O-methyl modified

<220>  
<221>  modified_base
<222>  (3)..(3)
<223>  2'-O-methyl modified

<220>  
<221>  modified_base
<222>  (4)..(4)
<223>  2'-O-methyl modified

<220>  
<221>  modified_base
<222>  (5)..(5)
<223>  2'-O-methyl modified

<220>  
<221>  modified_base
<222>  (6)..(6)
<223>  2'-O-methyl modified

<220>  
<221>  modified_base
<222>  (7)..(7)
<223>  2'-O-methyl modified

<220>  
<221>  modified_base
<222>  (8)..(8)
<223>  2'-fluoro modified

<220>  
<221>  modified_base
<222>  (9)..(9)
<223>  2'-fluoro modified

<220>  
<221>  modified_base
<222>  (10)..(10)
<223>  2'-fluoro modified

<220>  
<221>  modified_base
<222>  (11)..(11)
<223>  2'-fluoro modified

<220>  
<221>  modified_base
<222>  (12)..(12)
<223>  2'-O-methyl modified

<220>  
<221>  modified_base
<222>  (13)..(13)
<223>  2'-O-methyl modified

<220>  
<221>  modified_base
<222>  (14)..(14)
<223>  2'-O-methyl modified

<220>  
<221>  modified_base
<222>  (15)..(15)
<223>  2'-O-methyl modified

<220>  
<221>  modified_base
<222>  (16)..(16)
<223>  2'-O-methyl modified

<220>  
<221>  modified_base
<222>  (17)..(17)
<223>  2'-O-methyl modified

<220>  
<221>  modified_base
<222>  (18)..(18)
<223>  2'-O-methyl modified

<220>  
<221>  modified_base
<222>  (19)..(19)
<223>  2'-O-methyl modified

<220>  
<221>  modified_base
<222>  (20)..(20)
<223>  2'-O-methyl modified

<220>  
<221>  modified_base
<222>  (21)..(21)
<223>  2'-O-methyl modified

<220>  
<221>  modified_base
<222>  (22)..(22)
<223>  2'-O-methyl modified

<220>  
<221>  modified_base
<222>  (23)..(23)
<223>  2'-O-methyl modified

<220>  
<221>  modified_base
<222>  (24)..(24)
<223>  2'-O-methyl modified

<220>  
<221>  modified_base
<222>  (25)..(25)
<223>  2'-O-methyl modified

<220>  
<221>  modified_base
<222>  (26)..(26)
<223>  2'-O-methyl modified

<220>  
<221>  modified_base
<222>  (27)..(27)
<223>  2'-O-methyl modified

<220>  
<221>  modified_base
<222>  (28)..(28)
<223>  GalNAc-conjugated

<220>  
<221>  modified_base
<222>  (29)..(29)
<223>  GalNAc-conjugated

<220>  
<221>  modified_base
<222>  (30)..(30)
<223>  GalNAc-conjugated

<220>  
<221>  modified_base
<222>  (31)..(31)
<223>  2'-O-methyl modified

<220>  
<221>  modified_base
<222>  (32)..(32)
<223>  2'-O-methyl modified

<220>  
<221>  modified_base
<222>  (33)..(33)
<223>  2'-O-methyl modified

<220>  
<221>  modified_base
<222>  (34)..(34)
<223>  2'-O-methyl modified

<220>  
<221>  modified_base
<222>  (35)..(35)
<223>  2'-O-methyl modified

<220>  
<221>  modified_base
<222>  (36)..(36)
<223>  2'-O-methyl modified

<400>  1012
cugcgucugc aggacaaaaa gcagccgaaa ggcugc                                 36


<210>  1013
<211>  36
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  Modified sense strand


<220>
<221>  misc_feature
<222>  (1)..(2)
<223>  linked via phosphorothioate

<220>  
<221>  modified_base
<222>  (1)..(1)
<223>  2'-O-methyl modified

<220>  
<221>  modified_base
<222>  (2)..(2)
<223>  2'-O-methyl modified

<220>  
<221>  modified_base
<222>  (3)..(3)
<223>  2'-O-methyl modified

<220>  
<221>  modified_base
<222>  (4)..(4)
<223>  2'-O-methyl modified

<220>  
<221>  modified_base
<222>  (5)..(5)
<223>  2'-O-methyl modified

<220>  
<221>  modified_base
<222>  (6)..(6)
<223>  2'-O-methyl modified

<220>  
<221>  modified_base
<222>  (7)..(7)
<223>  2'-O-methyl modified

<220>  
<221>  modified_base
<222>  (8)..(8)
<223>  2'-fluoro modified

<220>  
<221>  modified_base
<222>  (9)..(9)
<223>  2'-fluoro modified

<220>  
<221>  modified_base
<222>  (10)..(10)
<223>  2'-fluoro modified

<220>  
<221>  modified_base
<222>  (11)..(11)
<223>  2'-fluoro modified

<220>  
<221>  modified_base
<222>  (12)..(12)
<223>  2'-O-methyl modified

<220>  
<221>  modified_base
<222>  (13)..(13)
<223>  2'-O-methyl modified

<220>  
<221>  modified_base
<222>  (14)..(14)
<223>  2'-O-methyl modified

<220>  
<221>  modified_base
<222>  (15)..(15)
<223>  2'-O-methyl modified

<220>  
<221>  modified_base
<222>  (16)..(16)
<223>  2'-O-methyl modified

<220>  
<221>  modified_base
<222>  (17)..(17)
<223>  2'-O-methyl modified

<220>  
<221>  modified_base
<222>  (18)..(18)
<223>  2'-O-methyl modified

<220>  
<221>  modified_base
<222>  (19)..(19)
<223>  2'-O-methyl modified

<220>  
<221>  modified_base
<222>  (20)..(20)
<223>  2'-O-methyl modified

<220>  
<221>  modified_base
<222>  (21)..(21)
<223>  2'-O-methyl modified

<220>  
<221>  modified_base
<222>  (22)..(22)
<223>  2'-O-methyl modified

<220>  
<221>  modified_base
<222>  (23)..(23)
<223>  2'-O-methyl modified

<220>  
<221>  modified_base
<222>  (24)..(24)
<223>  2'-O-methyl modified

<220>  
<221>  modified_base
<222>  (25)..(25)
<223>  2'-O-methyl modified

<220>  
<221>  modified_base
<222>  (26)..(26)
<223>  2'-O-methyl modified

<220>  
<221>  modified_base
<222>  (27)..(27)
<223>  2'-O-methyl modified

<220>  
<221>  modified_base
<222>  (28)..(28)
<223>  GalNAc-conjugated

<220>  
<221>  modified_base
<222>  (29)..(29)
<223>  GalNAc-conjugated

<220>  
<221>  modified_base
<222>  (30)..(30)
<223>  GalNAc-conjugated

<220>  
<221>  modified_base
<222>  (31)..(31)
<223>  2'-O-methyl modified

<220>  
<221>  modified_base
<222>  (32)..(32)
<223>  2'-O-methyl modified

<220>  
<221>  modified_base
<222>  (33)..(33)
<223>  2'-O-methyl modified

<220>  
<221>  modified_base
<222>  (34)..(34)
<223>  2'-O-methyl modified

<220>  
<221>  modified_base
<222>  (35)..(35)
<223>  2'-O-methyl modified

<220>  
<221>  modified_base
<222>  (36)..(36)
<223>  2'-O-methyl modified

<400>  1013
caggacaaaa agcucccaca gcagccgaaa ggcugc                                 36


<210>  1014
<211>  36
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  Modified sense strand


<220>
<221>  misc_feature
<222>  (1)..(2)
<223>  linked via phosphorothioate

<220>  
<221>  modified_base
<222>  (1)..(1)
<223>  2'-O-methyl modified

<220>  
<221>  modified_base
<222>  (2)..(2)
<223>  2'-O-methyl modified

<220>  
<221>  modified_base
<222>  (3)..(3)
<223>  2'-O-methyl modified

<220>  
<221>  modified_base
<222>  (4)..(4)
<223>  2'-O-methyl modified

<220>  
<221>  modified_base
<222>  (5)..(5)
<223>  2'-O-methyl modified

<220>  
<221>  modified_base
<222>  (6)..(6)
<223>  2'-O-methyl modified

<220>  
<221>  modified_base
<222>  (7)..(7)
<223>  2'-O-methyl modified

<220>  
<221>  modified_base
<222>  (8)..(8)
<223>  2'-fluoro modified

<220>  
<221>  modified_base
<222>  (9)..(9)
<223>  2'-fluoro modified

<220>  
<221>  modified_base
<222>  (10)..(10)
<223>  2'-fluoro modified

<220>  
<221>  modified_base
<222>  (11)..(11)
<223>  2'-fluoro modified

<220>  
<221>  modified_base
<222>  (12)..(12)
<223>  2'-O-methyl modified

<220>  
<221>  modified_base
<222>  (13)..(13)
<223>  2'-O-methyl modified

<220>  
<221>  modified_base
<222>  (14)..(14)
<223>  2'-O-methyl modified

<220>  
<221>  modified_base
<222>  (15)..(15)
<223>  2'-O-methyl modified

<220>  
<221>  modified_base
<222>  (16)..(16)
<223>  2'-O-methyl modified

<220>  
<221>  modified_base
<222>  (17)..(17)
<223>  2'-O-methyl modified

<220>  
<221>  modified_base
<222>  (18)..(18)
<223>  2'-O-methyl modified

<220>  
<221>  modified_base
<222>  (19)..(19)
<223>  2'-O-methyl modified

<220>  
<221>  modified_base
<222>  (20)..(20)
<223>  2'-O-methyl modified

<220>  
<221>  modified_base
<222>  (21)..(21)
<223>  2'-O-methyl modified

<220>  
<221>  modified_base
<222>  (22)..(22)
<223>  2'-O-methyl modified

<220>  
<221>  modified_base
<222>  (23)..(23)
<223>  2'-O-methyl modified

<220>  
<221>  modified_base
<222>  (24)..(24)
<223>  2'-O-methyl modified

<220>  
<221>  modified_base
<222>  (25)..(25)
<223>  2'-O-methyl modified

<220>  
<221>  modified_base
<222>  (26)..(26)
<223>  2'-O-methyl modified

<220>  
<221>  modified_base
<222>  (27)..(27)
<223>  2'-O-methyl modified

<220>  
<221>  modified_base
<222>  (28)..(28)
<223>  GalNAc-conjugated

<220>  
<221>  modified_base
<222>  (29)..(29)
<223>  GalNAc-conjugated

<220>  
<221>  modified_base
<222>  (30)..(30)
<223>  GalNAc-conjugated

<220>  
<221>  modified_base
<222>  (31)..(31)
<223>  2'-O-methyl modified

<220>  
<221>  modified_base
<222>  (32)..(32)
<223>  2'-O-methyl modified

<220>  
<221>  modified_base
<222>  (33)..(33)
<223>  2'-O-methyl modified

<220>  
<221>  modified_base
<222>  (34)..(34)
<223>  2'-O-methyl modified

<220>  
<221>  modified_base
<222>  (35)..(35)
<223>  2'-O-methyl modified

<220>  
<221>  modified_base
<222>  (36)..(36)
<223>  2'-O-methyl modified

<400>  1014
ucugagaucu gggaugugca gcagccgaaa ggcugc                                 36


<210>  1015
<211>  36
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  Modified sense strand


<220>
<221>  misc_feature
<222>  (1)..(2)
<223>  linked via phosphorothioate

<220>  
<221>  modified_base
<222>  (1)..(1)
<223>  2'-O-methyl modified

<220>  
<221>  modified_base
<222>  (2)..(2)
<223>  2'-O-methyl modified

<220>  
<221>  modified_base
<222>  (3)..(3)
<223>  2'-O-methyl modified

<220>  
<221>  modified_base
<222>  (4)..(4)
<223>  2'-O-methyl modified

<220>  
<221>  modified_base
<222>  (5)..(5)
<223>  2'-O-methyl modified

<220>  
<221>  modified_base
<222>  (6)..(6)
<223>  2'-O-methyl modified

<220>  
<221>  modified_base
<222>  (7)..(7)
<223>  2'-O-methyl modified

<220>  
<221>  modified_base
<222>  (8)..(8)
<223>  2'-fluoro modified

<220>  
<221>  modified_base
<222>  (9)..(9)
<223>  2'-fluoro modified

<220>  
<221>  modified_base
<222>  (10)..(10)
<223>  2'-fluoro modified

<220>  
<221>  modified_base
<222>  (11)..(11)
<223>  2'-fluoro modified

<220>  
<221>  modified_base
<222>  (12)..(12)
<223>  2'-O-methyl modified

<220>  
<221>  modified_base
<222>  (13)..(13)
<223>  2'-O-methyl modified

<220>  
<221>  modified_base
<222>  (14)..(14)
<223>  2'-O-methyl modified

<220>  
<221>  modified_base
<222>  (15)..(15)
<223>  2'-O-methyl modified

<220>  
<221>  modified_base
<222>  (16)..(16)
<223>  2'-O-methyl modified

<220>  
<221>  modified_base
<222>  (17)..(17)
<223>  2'-O-methyl modified

<220>  
<221>  modified_base
<222>  (18)..(18)
<223>  2'-O-methyl modified

<220>  
<221>  modified_base
<222>  (19)..(19)
<223>  2'-O-methyl modified

<220>  
<221>  modified_base
<222>  (20)..(20)
<223>  2'-O-methyl modified

<220>  
<221>  modified_base
<222>  (21)..(21)
<223>  2'-O-methyl modified

<220>  
<221>  modified_base
<222>  (22)..(22)
<223>  2'-O-methyl modified

<220>  
<221>  modified_base
<222>  (23)..(23)
<223>  2'-O-methyl modified

<220>  
<221>  modified_base
<222>  (24)..(24)
<223>  2'-O-methyl modified

<220>  
<221>  modified_base
<222>  (25)..(25)
<223>  2'-O-methyl modified

<220>  
<221>  modified_base
<222>  (26)..(26)
<223>  2'-O-methyl modified

<220>  
<221>  modified_base
<222>  (27)..(27)
<223>  2'-O-methyl modified

<220>  
<221>  modified_base
<222>  (28)..(28)
<223>  GalNAc-conjugated

<220>  
<221>  modified_base
<222>  (29)..(29)
<223>  GalNAc-conjugated

<220>  
<221>  modified_base
<222>  (30)..(30)
<223>  GalNAc-conjugated

<220>  
<221>  modified_base
<222>  (31)..(31)
<223>  2'-O-methyl modified

<220>  
<221>  modified_base
<222>  (32)..(32)
<223>  2'-O-methyl modified

<220>  
<221>  modified_base
<222>  (33)..(33)
<223>  2'-O-methyl modified

<220>  
<221>  modified_base
<222>  (34)..(34)
<223>  2'-O-methyl modified

<220>  
<221>  modified_base
<222>  (35)..(35)
<223>  2'-O-methyl modified

<220>  
<221>  modified_base
<222>  (36)..(36)
<223>  2'-O-methyl modified

<400>  1015
gaucugggau gugcacgaaa gcagccgaaa ggcugc                                 36


<210>  1016
<211>  36
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  Modified sense strand


<220>
<221>  misc_feature
<222>  (1)..(2)
<223>  linked via phosphorothioate

<220>  
<221>  modified_base
<222>  (1)..(1)
<223>  2'-O-methyl modified

<220>  
<221>  modified_base
<222>  (2)..(2)
<223>  2'-O-methyl modified

<220>  
<221>  modified_base
<222>  (3)..(3)
<223>  2'-O-methyl modified

<220>  
<221>  modified_base
<222>  (4)..(4)
<223>  2'-O-methyl modified

<220>  
<221>  modified_base
<222>  (5)..(5)
<223>  2'-O-methyl modified

<220>  
<221>  modified_base
<222>  (6)..(6)
<223>  2'-O-methyl modified

<220>  
<221>  modified_base
<222>  (7)..(7)
<223>  2'-O-methyl modified

<220>  
<221>  modified_base
<222>  (8)..(8)
<223>  2'-fluoro modified

<220>  
<221>  modified_base
<222>  (9)..(9)
<223>  2'-fluoro modified

<220>  
<221>  modified_base
<222>  (10)..(10)
<223>  2'-fluoro modified

<220>  
<221>  modified_base
<222>  (11)..(11)
<223>  2'-fluoro modified

<220>  
<221>  modified_base
<222>  (12)..(12)
<223>  2'-O-methyl modified

<220>  
<221>  modified_base
<222>  (13)..(13)
<223>  2'-O-methyl modified

<220>  
<221>  modified_base
<222>  (14)..(14)
<223>  2'-O-methyl modified

<220>  
<221>  modified_base
<222>  (15)..(15)
<223>  2'-O-methyl modified

<220>  
<221>  modified_base
<222>  (16)..(16)
<223>  2'-O-methyl modified

<220>  
<221>  modified_base
<222>  (17)..(17)
<223>  2'-O-methyl modified

<220>  
<221>  modified_base
<222>  (18)..(18)
<223>  2'-O-methyl modified

<220>  
<221>  modified_base
<222>  (19)..(19)
<223>  2'-O-methyl modified

<220>  
<221>  modified_base
<222>  (20)..(20)
<223>  2'-O-methyl modified

<220>  
<221>  modified_base
<222>  (21)..(21)
<223>  2'-O-methyl modified

<220>  
<221>  modified_base
<222>  (22)..(22)
<223>  2'-O-methyl modified

<220>  
<221>  modified_base
<222>  (23)..(23)
<223>  2'-O-methyl modified

<220>  
<221>  modified_base
<222>  (24)..(24)
<223>  2'-O-methyl modified

<220>  
<221>  modified_base
<222>  (25)..(25)
<223>  2'-O-methyl modified

<220>  
<221>  modified_base
<222>  (26)..(26)
<223>  2'-O-methyl modified

<220>  
<221>  modified_base
<222>  (27)..(27)
<223>  2'-O-methyl modified

<220>  
<221>  modified_base
<222>  (28)..(28)
<223>  GalNAc-conjugated

<220>  
<221>  modified_base
<222>  (29)..(29)
<223>  GalNAc-conjugated

<220>  
<221>  modified_base
<222>  (30)..(30)
<223>  GalNAc-conjugated

<220>  
<221>  modified_base
<222>  (31)..(31)
<223>  2'-O-methyl modified

<220>  
<221>  modified_base
<222>  (32)..(32)
<223>  2'-O-methyl modified

<220>  
<221>  modified_base
<222>  (33)..(33)
<223>  2'-O-methyl modified

<220>  
<221>  modified_base
<222>  (34)..(34)
<223>  2'-O-methyl modified

<220>  
<221>  modified_base
<222>  (35)..(35)
<223>  2'-O-methyl modified

<220>  
<221>  modified_base
<222>  (36)..(36)
<223>  2'-O-methyl modified

<400>  1016
aucugggaug ugcacgaaua gcagccgaaa ggcugc                                 36


<210>  1017
<211>  36
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  Modified sense strand


<220>
<221>  misc_feature
<222>  (1)..(2)
<223>  linked via phosphorothioate

<220>  
<221>  modified_base
<222>  (1)..(1)
<223>  2'-O-methyl modified

<220>  
<221>  modified_base
<222>  (2)..(2)
<223>  2'-O-methyl modified

<220>  
<221>  modified_base
<222>  (3)..(3)
<223>  2'-O-methyl modified

<220>  
<221>  modified_base
<222>  (4)..(4)
<223>  2'-O-methyl modified

<220>  
<221>  modified_base
<222>  (5)..(5)
<223>  2'-O-methyl modified

<220>  
<221>  modified_base
<222>  (6)..(6)
<223>  2'-O-methyl modified

<220>  
<221>  modified_base
<222>  (7)..(7)
<223>  2'-O-methyl modified

<220>  
<221>  modified_base
<222>  (8)..(8)
<223>  2'-fluoro modified

<220>  
<221>  modified_base
<222>  (9)..(9)
<223>  2'-fluoro modified

<220>  
<221>  modified_base
<222>  (10)..(10)
<223>  2'-fluoro modified

<220>  
<221>  modified_base
<222>  (11)..(11)
<223>  2'-fluoro modified

<220>  
<221>  modified_base
<222>  (12)..(12)
<223>  2'-O-methyl modified

<220>  
<221>  modified_base
<222>  (13)..(13)
<223>  2'-O-methyl modified

<220>  
<221>  modified_base
<222>  (14)..(14)
<223>  2'-O-methyl modified

<220>  
<221>  modified_base
<222>  (15)..(15)
<223>  2'-O-methyl modified

<220>  
<221>  modified_base
<222>  (16)..(16)
<223>  2'-O-methyl modified

<220>  
<221>  modified_base
<222>  (17)..(17)
<223>  2'-O-methyl modified

<220>  
<221>  modified_base
<222>  (18)..(18)
<223>  2'-O-methyl modified

<220>  
<221>  modified_base
<222>  (19)..(19)
<223>  2'-O-methyl modified

<220>  
<221>  modified_base
<222>  (20)..(20)
<223>  2'-O-methyl modified

<220>  
<221>  modified_base
<222>  (21)..(21)
<223>  2'-O-methyl modified

<220>  
<221>  modified_base
<222>  (22)..(22)
<223>  2'-O-methyl modified

<220>  
<221>  modified_base
<222>  (23)..(23)
<223>  2'-O-methyl modified

<220>  
<221>  modified_base
<222>  (24)..(24)
<223>  2'-O-methyl modified

<220>  
<221>  modified_base
<222>  (25)..(25)
<223>  2'-O-methyl modified

<220>  
<221>  modified_base
<222>  (26)..(26)
<223>  2'-O-methyl modified

<220>  
<221>  modified_base
<222>  (27)..(27)
<223>  2'-O-methyl modified

<220>  
<221>  modified_base
<222>  (28)..(28)
<223>  GalNAc-conjugated

<220>  
<221>  modified_base
<222>  (29)..(29)
<223>  GalNAc-conjugated

<220>  
<221>  modified_base
<222>  (30)..(30)
<223>  GalNAc-conjugated

<220>  
<221>  modified_base
<222>  (31)..(31)
<223>  2'-O-methyl modified

<220>  
<221>  modified_base
<222>  (32)..(32)
<223>  2'-O-methyl modified

<220>  
<221>  modified_base
<222>  (33)..(33)
<223>  2'-O-methyl modified

<220>  
<221>  modified_base
<222>  (34)..(34)
<223>  2'-O-methyl modified

<220>  
<221>  modified_base
<222>  (35)..(35)
<223>  2'-O-methyl modified

<220>  
<221>  modified_base
<222>  (36)..(36)
<223>  2'-O-methyl modified

<400>  1017
ucugggaugu gcacgaauga gcagccgaaa ggcugc                                 36


<210>  1018
<211>  36
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  Modified sense strand


<220>
<221>  misc_feature
<222>  (1)..(2)
<223>  linked via phosphorothioate

<220>  
<221>  modified_base
<222>  (1)..(1)
<223>  2'-O-methyl modified

<220>  
<221>  modified_base
<222>  (2)..(2)
<223>  2'-O-methyl modified

<220>  
<221>  modified_base
<222>  (3)..(3)
<223>  2'-O-methyl modified

<220>  
<221>  modified_base
<222>  (4)..(4)
<223>  2'-O-methyl modified

<220>  
<221>  modified_base
<222>  (5)..(5)
<223>  2'-O-methyl modified

<220>  
<221>  modified_base
<222>  (6)..(6)
<223>  2'-O-methyl modified

<220>  
<221>  modified_base
<222>  (7)..(7)
<223>  2'-O-methyl modified

<220>  
<221>  modified_base
<222>  (8)..(8)
<223>  2'-fluoro modified

<220>  
<221>  modified_base
<222>  (9)..(9)
<223>  2'-fluoro modified

<220>  
<221>  modified_base
<222>  (10)..(10)
<223>  2'-fluoro modified

<220>  
<221>  modified_base
<222>  (11)..(11)
<223>  2'-fluoro modified

<220>  
<221>  modified_base
<222>  (12)..(12)
<223>  2'-O-methyl modified

<220>  
<221>  modified_base
<222>  (13)..(13)
<223>  2'-O-methyl modified

<220>  
<221>  modified_base
<222>  (14)..(14)
<223>  2'-O-methyl modified

<220>  
<221>  modified_base
<222>  (15)..(15)
<223>  2'-O-methyl modified

<220>  
<221>  modified_base
<222>  (16)..(16)
<223>  2'-O-methyl modified

<220>  
<221>  modified_base
<222>  (17)..(17)
<223>  2'-O-methyl modified

<220>  
<221>  modified_base
<222>  (18)..(18)
<223>  2'-O-methyl modified

<220>  
<221>  modified_base
<222>  (19)..(19)
<223>  2'-O-methyl modified

<220>  
<221>  modified_base
<222>  (20)..(20)
<223>  2'-O-methyl modified

<220>  
<221>  modified_base
<222>  (21)..(21)
<223>  2'-O-methyl modified

<220>  
<221>  modified_base
<222>  (22)..(22)
<223>  2'-O-methyl modified

<220>  
<221>  modified_base
<222>  (23)..(23)
<223>  2'-O-methyl modified

<220>  
<221>  modified_base
<222>  (24)..(24)
<223>  2'-O-methyl modified

<220>  
<221>  modified_base
<222>  (25)..(25)
<223>  2'-O-methyl modified

<220>  
<221>  modified_base
<222>  (26)..(26)
<223>  2'-O-methyl modified

<220>  
<221>  modified_base
<222>  (27)..(27)
<223>  2'-O-methyl modified

<220>  
<221>  modified_base
<222>  (28)..(28)
<223>  GalNAc-conjugated

<220>  
<221>  modified_base
<222>  (29)..(29)
<223>  GalNAc-conjugated

<220>  
<221>  modified_base
<222>  (30)..(30)
<223>  GalNAc-conjugated

<220>  
<221>  modified_base
<222>  (31)..(31)
<223>  2'-O-methyl modified

<220>  
<221>  modified_base
<222>  (32)..(32)
<223>  2'-O-methyl modified

<220>  
<221>  modified_base
<222>  (33)..(33)
<223>  2'-O-methyl modified

<220>  
<221>  modified_base
<222>  (34)..(34)
<223>  2'-O-methyl modified

<220>  
<221>  modified_base
<222>  (35)..(35)
<223>  2'-O-methyl modified

<220>  
<221>  modified_base
<222>  (36)..(36)
<223>  2'-O-methyl modified

<400>  1018
augugcacga augacuguua gcagccgaaa ggcugc                                 36


<210>  1019
<211>  36
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  Modified sense strand


<220>
<221>  misc_feature
<222>  (1)..(2)
<223>  linked via phosphorothioate

<220>  
<221>  modified_base
<222>  (1)..(1)
<223>  2'-O-methyl modified

<220>  
<221>  modified_base
<222>  (2)..(2)
<223>  2'-O-methyl modified

<220>  
<221>  modified_base
<222>  (3)..(3)
<223>  2'-O-methyl modified

<220>  
<221>  modified_base
<222>  (4)..(4)
<223>  2'-O-methyl modified

<220>  
<221>  modified_base
<222>  (5)..(5)
<223>  2'-O-methyl modified

<220>  
<221>  modified_base
<222>  (6)..(6)
<223>  2'-O-methyl modified

<220>  
<221>  modified_base
<222>  (7)..(7)
<223>  2'-O-methyl modified

<220>  
<221>  modified_base
<222>  (8)..(8)
<223>  2'-fluoro modified

<220>  
<221>  modified_base
<222>  (9)..(9)
<223>  2'-fluoro modified

<220>  
<221>  modified_base
<222>  (10)..(10)
<223>  2'-fluoro modified

<220>  
<221>  modified_base
<222>  (11)..(11)
<223>  2'-fluoro modified

<220>  
<221>  modified_base
<222>  (12)..(12)
<223>  2'-O-methyl modified

<220>  
<221>  modified_base
<222>  (13)..(13)
<223>  2'-O-methyl modified

<220>  
<221>  modified_base
<222>  (14)..(14)
<223>  2'-O-methyl modified

<220>  
<221>  modified_base
<222>  (15)..(15)
<223>  2'-O-methyl modified

<220>  
<221>  modified_base
<222>  (16)..(16)
<223>  2'-O-methyl modified

<220>  
<221>  modified_base
<222>  (17)..(17)
<223>  2'-O-methyl modified

<220>  
<221>  modified_base
<222>  (18)..(18)
<223>  2'-O-methyl modified

<220>  
<221>  modified_base
<222>  (19)..(19)
<223>  2'-O-methyl modified

<220>  
<221>  modified_base
<222>  (20)..(20)
<223>  2'-O-methyl modified

<220>  
<221>  modified_base
<222>  (21)..(21)
<223>  2'-O-methyl modified

<220>  
<221>  modified_base
<222>  (22)..(22)
<223>  2'-O-methyl modified

<220>  
<221>  modified_base
<222>  (23)..(23)
<223>  2'-O-methyl modified

<220>  
<221>  modified_base
<222>  (24)..(24)
<223>  2'-O-methyl modified

<220>  
<221>  modified_base
<222>  (25)..(25)
<223>  2'-O-methyl modified

<220>  
<221>  modified_base
<222>  (26)..(26)
<223>  2'-O-methyl modified

<220>  
<221>  modified_base
<222>  (27)..(27)
<223>  2'-O-methyl modified

<220>  
<221>  modified_base
<222>  (28)..(28)
<223>  GalNAc-conjugated

<220>  
<221>  modified_base
<222>  (29)..(29)
<223>  GalNAc-conjugated

<220>  
<221>  modified_base
<222>  (30)..(30)
<223>  GalNAc-conjugated

<220>  
<221>  modified_base
<222>  (31)..(31)
<223>  2'-O-methyl modified

<220>  
<221>  modified_base
<222>  (32)..(32)
<223>  2'-O-methyl modified

<220>  
<221>  modified_base
<222>  (33)..(33)
<223>  2'-O-methyl modified

<220>  
<221>  modified_base
<222>  (34)..(34)
<223>  2'-O-methyl modified

<220>  
<221>  modified_base
<222>  (35)..(35)
<223>  2'-O-methyl modified

<220>  
<221>  modified_base
<222>  (36)..(36)
<223>  2'-O-methyl modified

<400>  1019
ugugcacgaa ugacuguuca gcagccgaaa ggcugc                                 36


<210>  1020
<211>  36
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  Modified sense strand


<220>
<221>  misc_feature
<222>  (1)..(2)
<223>  linked via phosphorothioate

<220>  
<221>  modified_base
<222>  (1)..(1)
<223>  2'-O-methyl modified

<220>  
<221>  modified_base
<222>  (2)..(2)
<223>  2'-O-methyl modified

<220>  
<221>  modified_base
<222>  (3)..(3)
<223>  2'-O-methyl modified

<220>  
<221>  modified_base
<222>  (4)..(4)
<223>  2'-O-methyl modified

<220>  
<221>  modified_base
<222>  (5)..(5)
<223>  2'-O-methyl modified

<220>  
<221>  modified_base
<222>  (6)..(6)
<223>  2'-O-methyl modified

<220>  
<221>  modified_base
<222>  (7)..(7)
<223>  2'-O-methyl modified

<220>  
<221>  modified_base
<222>  (8)..(8)
<223>  2'-fluoro modified

<220>  
<221>  modified_base
<222>  (9)..(9)
<223>  2'-fluoro modified

<220>  
<221>  modified_base
<222>  (10)..(10)
<223>  2'-fluoro modified

<220>  
<221>  modified_base
<222>  (11)..(11)
<223>  2'-fluoro modified

<220>  
<221>  modified_base
<222>  (12)..(12)
<223>  2'-O-methyl modified

<220>  
<221>  modified_base
<222>  (13)..(13)
<223>  2'-O-methyl modified

<220>  
<221>  modified_base
<222>  (14)..(14)
<223>  2'-O-methyl modified

<220>  
<221>  modified_base
<222>  (15)..(15)
<223>  2'-O-methyl modified

<220>  
<221>  modified_base
<222>  (16)..(16)
<223>  2'-O-methyl modified

<220>  
<221>  modified_base
<222>  (17)..(17)
<223>  2'-O-methyl modified

<220>  
<221>  modified_base
<222>  (18)..(18)
<223>  2'-O-methyl modified

<220>  
<221>  modified_base
<222>  (19)..(19)
<223>  2'-O-methyl modified

<220>  
<221>  modified_base
<222>  (20)..(20)
<223>  2'-O-methyl modified

<220>  
<221>  modified_base
<222>  (21)..(21)
<223>  2'-O-methyl modified

<220>  
<221>  modified_base
<222>  (22)..(22)
<223>  2'-O-methyl modified

<220>  
<221>  modified_base
<222>  (23)..(23)
<223>  2'-O-methyl modified

<220>  
<221>  modified_base
<222>  (24)..(24)
<223>  2'-O-methyl modified

<220>  
<221>  modified_base
<222>  (25)..(25)
<223>  2'-O-methyl modified

<220>  
<221>  modified_base
<222>  (26)..(26)
<223>  2'-O-methyl modified

<220>  
<221>  modified_base
<222>  (27)..(27)
<223>  2'-O-methyl modified

<220>  
<221>  modified_base
<222>  (28)..(28)
<223>  GalNAc-conjugated

<220>  
<221>  modified_base
<222>  (29)..(29)
<223>  GalNAc-conjugated

<220>  
<221>  modified_base
<222>  (30)..(30)
<223>  GalNAc-conjugated

<220>  
<221>  modified_base
<222>  (31)..(31)
<223>  2'-O-methyl modified

<220>  
<221>  modified_base
<222>  (32)..(32)
<223>  2'-O-methyl modified

<220>  
<221>  modified_base
<222>  (33)..(33)
<223>  2'-O-methyl modified

<220>  
<221>  modified_base
<222>  (34)..(34)
<223>  2'-O-methyl modified

<220>  
<221>  modified_base
<222>  (35)..(35)
<223>  2'-O-methyl modified

<220>  
<221>  modified_base
<222>  (36)..(36)
<223>  2'-O-methyl modified

<400>  1020
gugcacgaau gacuguucua gcagccgaaa ggcugc                                 36


<210>  1021
<211>  36
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  Modified sense strand


<220>
<221>  misc_feature
<222>  (1)..(2)
<223>  linked via phosphorothioate

<220>  
<221>  modified_base
<222>  (1)..(1)
<223>  2'-O-methyl modified

<220>  
<221>  modified_base
<222>  (2)..(2)
<223>  2'-O-methyl modified

<220>  
<221>  modified_base
<222>  (3)..(3)
<223>  2'-O-methyl modified

<220>  
<221>  modified_base
<222>  (4)..(4)
<223>  2'-O-methyl modified

<220>  
<221>  modified_base
<222>  (5)..(5)
<223>  2'-O-methyl modified

<220>  
<221>  modified_base
<222>  (6)..(6)
<223>  2'-O-methyl modified

<220>  
<221>  modified_base
<222>  (7)..(7)
<223>  2'-O-methyl modified

<220>  
<221>  modified_base
<222>  (8)..(8)
<223>  2'-fluoro modified

<220>  
<221>  modified_base
<222>  (9)..(9)
<223>  2'-fluoro modified

<220>  
<221>  modified_base
<222>  (10)..(10)
<223>  2'-fluoro modified

<220>  
<221>  modified_base
<222>  (11)..(11)
<223>  2'-fluoro modified

<220>  
<221>  modified_base
<222>  (12)..(12)
<223>  2'-O-methyl modified

<220>  
<221>  modified_base
<222>  (13)..(13)
<223>  2'-O-methyl modified

<220>  
<221>  modified_base
<222>  (14)..(14)
<223>  2'-O-methyl modified

<220>  
<221>  modified_base
<222>  (15)..(15)
<223>  2'-O-methyl modified

<220>  
<221>  modified_base
<222>  (16)..(16)
<223>  2'-O-methyl modified

<220>  
<221>  modified_base
<222>  (17)..(17)
<223>  2'-O-methyl modified

<220>  
<221>  modified_base
<222>  (18)..(18)
<223>  2'-O-methyl modified

<220>  
<221>  modified_base
<222>  (19)..(19)
<223>  2'-O-methyl modified

<220>  
<221>  modified_base
<222>  (20)..(20)
<223>  2'-O-methyl modified

<220>  
<221>  modified_base
<222>  (21)..(21)
<223>  2'-O-methyl modified

<220>  
<221>  modified_base
<222>  (22)..(22)
<223>  2'-O-methyl modified

<220>  
<221>  modified_base
<222>  (23)..(23)
<223>  2'-O-methyl modified

<220>  
<221>  modified_base
<222>  (24)..(24)
<223>  2'-O-methyl modified

<220>  
<221>  modified_base
<222>  (25)..(25)
<223>  2'-O-methyl modified

<220>  
<221>  modified_base
<222>  (26)..(26)
<223>  2'-O-methyl modified

<220>  
<221>  modified_base
<222>  (27)..(27)
<223>  2'-O-methyl modified

<220>  
<221>  modified_base
<222>  (28)..(28)
<223>  GalNAc-conjugated

<220>  
<221>  modified_base
<222>  (29)..(29)
<223>  GalNAc-conjugated

<220>  
<221>  modified_base
<222>  (30)..(30)
<223>  GalNAc-conjugated

<220>  
<221>  modified_base
<222>  (31)..(31)
<223>  2'-O-methyl modified

<220>  
<221>  modified_base
<222>  (32)..(32)
<223>  2'-O-methyl modified

<220>  
<221>  modified_base
<222>  (33)..(33)
<223>  2'-O-methyl modified

<220>  
<221>  modified_base
<222>  (34)..(34)
<223>  2'-O-methyl modified

<220>  
<221>  modified_base
<222>  (35)..(35)
<223>  2'-O-methyl modified

<220>  
<221>  modified_base
<222>  (36)..(36)
<223>  2'-O-methyl modified

<400>  1021
ugccuccuag aaguggaaca gcagccgaaa ggcugc                                 36


<210>  1022
<211>  36
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  Modified sense strand


<220>
<221>  misc_feature
<222>  (1)..(2)
<223>  linked via phosphorothioate

<220>  
<221>  modified_base
<222>  (1)..(1)
<223>  2'-O-methyl modified

<220>  
<221>  modified_base
<222>  (2)..(2)
<223>  2'-O-methyl modified

<220>  
<221>  modified_base
<222>  (3)..(3)
<223>  2'-O-methyl modified

<220>  
<221>  modified_base
<222>  (4)..(4)
<223>  2'-O-methyl modified

<220>  
<221>  modified_base
<222>  (5)..(5)
<223>  2'-O-methyl modified

<220>  
<221>  modified_base
<222>  (6)..(6)
<223>  2'-O-methyl modified

<220>  
<221>  modified_base
<222>  (7)..(7)
<223>  2'-O-methyl modified

<220>  
<221>  modified_base
<222>  (8)..(8)
<223>  2'-fluoro modified

<220>  
<221>  modified_base
<222>  (9)..(9)
<223>  2'-fluoro modified

<220>  
<221>  modified_base
<222>  (10)..(10)
<223>  2'-fluoro modified

<220>  
<221>  modified_base
<222>  (11)..(11)
<223>  2'-fluoro modified

<220>  
<221>  modified_base
<222>  (12)..(12)
<223>  2'-O-methyl modified

<220>  
<221>  modified_base
<222>  (13)..(13)
<223>  2'-O-methyl modified

<220>  
<221>  modified_base
<222>  (14)..(14)
<223>  2'-O-methyl modified

<220>  
<221>  modified_base
<222>  (15)..(15)
<223>  2'-O-methyl modified

<220>  
<221>  modified_base
<222>  (16)..(16)
<223>  2'-O-methyl modified

<220>  
<221>  modified_base
<222>  (17)..(17)
<223>  2'-O-methyl modified

<220>  
<221>  modified_base
<222>  (18)..(18)
<223>  2'-O-methyl modified

<220>  
<221>  modified_base
<222>  (19)..(19)
<223>  2'-O-methyl modified

<220>  
<221>  modified_base
<222>  (20)..(20)
<223>  2'-O-methyl modified

<220>  
<221>  modified_base
<222>  (21)..(21)
<223>  2'-O-methyl modified

<220>  
<221>  modified_base
<222>  (22)..(22)
<223>  2'-O-methyl modified

<220>  
<221>  modified_base
<222>  (23)..(23)
<223>  2'-O-methyl modified

<220>  
<221>  modified_base
<222>  (24)..(24)
<223>  2'-O-methyl modified

<220>  
<221>  modified_base
<222>  (25)..(25)
<223>  2'-O-methyl modified

<220>  
<221>  modified_base
<222>  (26)..(26)
<223>  2'-O-methyl modified

<220>  
<221>  modified_base
<222>  (27)..(27)
<223>  2'-O-methyl modified

<220>  
<221>  modified_base
<222>  (28)..(28)
<223>  GalNAc-conjugated

<220>  
<221>  modified_base
<222>  (29)..(29)
<223>  GalNAc-conjugated

<220>  
<221>  modified_base
<222>  (30)..(30)
<223>  GalNAc-conjugated

<220>  
<221>  modified_base
<222>  (31)..(31)
<223>  2'-O-methyl modified

<220>  
<221>  modified_base
<222>  (32)..(32)
<223>  2'-O-methyl modified

<220>  
<221>  modified_base
<222>  (33)..(33)
<223>  2'-O-methyl modified

<220>  
<221>  modified_base
<222>  (34)..(34)
<223>  2'-O-methyl modified

<220>  
<221>  modified_base
<222>  (35)..(35)
<223>  2'-O-methyl modified

<220>  
<221>  modified_base
<222>  (36)..(36)
<223>  2'-O-methyl modified

<400>  1022
uagaagugga acagacugaa gcagccgaaa ggcugc                                 36


<210>  1023
<211>  36
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  Modified sense strand


<220>
<221>  misc_feature
<222>  (1)..(2)
<223>  linked via phosphorothioate

<220>  
<221>  modified_base
<222>  (1)..(1)
<223>  2'-O-methyl modified

<220>  
<221>  modified_base
<222>  (2)..(2)
<223>  2'-O-methyl modified

<220>  
<221>  modified_base
<222>  (3)..(3)
<223>  2'-O-methyl modified

<220>  
<221>  modified_base
<222>  (4)..(4)
<223>  2'-O-methyl modified

<220>  
<221>  modified_base
<222>  (5)..(5)
<223>  2'-O-methyl modified

<220>  
<221>  modified_base
<222>  (6)..(6)
<223>  2'-O-methyl modified

<220>  
<221>  modified_base
<222>  (7)..(7)
<223>  2'-O-methyl modified

<220>  
<221>  modified_base
<222>  (8)..(8)
<223>  2'-fluoro modified

<220>  
<221>  modified_base
<222>  (9)..(9)
<223>  2'-fluoro modified

<220>  
<221>  modified_base
<222>  (10)..(10)
<223>  2'-fluoro modified

<220>  
<221>  modified_base
<222>  (11)..(11)
<223>  2'-fluoro modified

<220>  
<221>  modified_base
<222>  (12)..(12)
<223>  2'-O-methyl modified

<220>  
<221>  modified_base
<222>  (13)..(13)
<223>  2'-O-methyl modified

<220>  
<221>  modified_base
<222>  (14)..(14)
<223>  2'-O-methyl modified

<220>  
<221>  modified_base
<222>  (15)..(15)
<223>  2'-O-methyl modified

<220>  
<221>  modified_base
<222>  (16)..(16)
<223>  2'-O-methyl modified

<220>  
<221>  modified_base
<222>  (17)..(17)
<223>  2'-O-methyl modified

<220>  
<221>  modified_base
<222>  (18)..(18)
<223>  2'-O-methyl modified

<220>  
<221>  modified_base
<222>  (19)..(19)
<223>  2'-O-methyl modified

<220>  
<221>  modified_base
<222>  (20)..(20)
<223>  2'-O-methyl modified

<220>  
<221>  modified_base
<222>  (21)..(21)
<223>  2'-O-methyl modified

<220>  
<221>  modified_base
<222>  (22)..(22)
<223>  2'-O-methyl modified

<220>  
<221>  modified_base
<222>  (23)..(23)
<223>  2'-O-methyl modified

<220>  
<221>  modified_base
<222>  (24)..(24)
<223>  2'-O-methyl modified

<220>  
<221>  modified_base
<222>  (25)..(25)
<223>  2'-O-methyl modified

<220>  
<221>  modified_base
<222>  (26)..(26)
<223>  2'-O-methyl modified

<220>  
<221>  modified_base
<222>  (27)..(27)
<223>  2'-O-methyl modified

<220>  
<221>  modified_base
<222>  (28)..(28)
<223>  GalNAc-conjugated

<220>  
<221>  modified_base
<222>  (29)..(29)
<223>  GalNAc-conjugated

<220>  
<221>  modified_base
<222>  (30)..(30)
<223>  GalNAc-conjugated

<220>  
<221>  modified_base
<222>  (31)..(31)
<223>  2'-O-methyl modified

<220>  
<221>  modified_base
<222>  (32)..(32)
<223>  2'-O-methyl modified

<220>  
<221>  modified_base
<222>  (33)..(33)
<223>  2'-O-methyl modified

<220>  
<221>  modified_base
<222>  (34)..(34)
<223>  2'-O-methyl modified

<220>  
<221>  modified_base
<222>  (35)..(35)
<223>  2'-O-methyl modified

<220>  
<221>  modified_base
<222>  (36)..(36)
<223>  2'-O-methyl modified

<400>  1023
agaaguggaa cagacugaga gcagccgaaa ggcugc                                 36


<210>  1024
<211>  36
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  Modified sense strand


<220>
<221>  misc_feature
<222>  (1)..(2)
<223>  linked via phosphorothioate

<220>  
<221>  modified_base
<222>  (1)..(1)
<223>  2'-O-methyl modified

<220>  
<221>  modified_base
<222>  (2)..(2)
<223>  2'-O-methyl modified

<220>  
<221>  modified_base
<222>  (3)..(3)
<223>  2'-O-methyl modified

<220>  
<221>  modified_base
<222>  (4)..(4)
<223>  2'-O-methyl modified

<220>  
<221>  modified_base
<222>  (5)..(5)
<223>  2'-O-methyl modified

<220>  
<221>  modified_base
<222>  (6)..(6)
<223>  2'-O-methyl modified

<220>  
<221>  modified_base
<222>  (7)..(7)
<223>  2'-O-methyl modified

<220>  
<221>  modified_base
<222>  (8)..(8)
<223>  2'-fluoro modified

<220>  
<221>  modified_base
<222>  (9)..(9)
<223>  2'-fluoro modified

<220>  
<221>  modified_base
<222>  (10)..(10)
<223>  2'-fluoro modified

<220>  
<221>  modified_base
<222>  (11)..(11)
<223>  2'-fluoro modified

<220>  
<221>  modified_base
<222>  (12)..(12)
<223>  2'-O-methyl modified

<220>  
<221>  modified_base
<222>  (13)..(13)
<223>  2'-O-methyl modified

<220>  
<221>  modified_base
<222>  (14)..(14)
<223>  2'-O-methyl modified

<220>  
<221>  modified_base
<222>  (15)..(15)
<223>  2'-O-methyl modified

<220>  
<221>  modified_base
<222>  (16)..(16)
<223>  2'-O-methyl modified

<220>  
<221>  modified_base
<222>  (17)..(17)
<223>  2'-O-methyl modified

<220>  
<221>  modified_base
<222>  (18)..(18)
<223>  2'-O-methyl modified

<220>  
<221>  modified_base
<222>  (19)..(19)
<223>  2'-O-methyl modified

<220>  
<221>  modified_base
<222>  (20)..(20)
<223>  2'-O-methyl modified

<220>  
<221>  modified_base
<222>  (21)..(21)
<223>  2'-O-methyl modified

<220>  
<221>  modified_base
<222>  (22)..(22)
<223>  2'-O-methyl modified

<220>  
<221>  modified_base
<222>  (23)..(23)
<223>  2'-O-methyl modified

<220>  
<221>  modified_base
<222>  (24)..(24)
<223>  2'-O-methyl modified

<220>  
<221>  modified_base
<222>  (25)..(25)
<223>  2'-O-methyl modified

<220>  
<221>  modified_base
<222>  (26)..(26)
<223>  2'-O-methyl modified

<220>  
<221>  modified_base
<222>  (27)..(27)
<223>  2'-O-methyl modified

<220>  
<221>  modified_base
<222>  (28)..(28)
<223>  GalNAc-conjugated

<220>  
<221>  modified_base
<222>  (29)..(29)
<223>  GalNAc-conjugated

<220>  
<221>  modified_base
<222>  (30)..(30)
<223>  GalNAc-conjugated

<220>  
<221>  modified_base
<222>  (31)..(31)
<223>  2'-O-methyl modified

<220>  
<221>  modified_base
<222>  (32)..(32)
<223>  2'-O-methyl modified

<220>  
<221>  modified_base
<222>  (33)..(33)
<223>  2'-O-methyl modified

<220>  
<221>  modified_base
<222>  (34)..(34)
<223>  2'-O-methyl modified

<220>  
<221>  modified_base
<222>  (35)..(35)
<223>  2'-O-methyl modified

<220>  
<221>  modified_base
<222>  (36)..(36)
<223>  2'-O-methyl modified

<400>  1024
gaaguggaac agacugagaa gcagccgaaa ggcugc                                 36


<210>  1025
<211>  36
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  Modified sense strand


<220>
<221>  misc_feature
<222>  (1)..(2)
<223>  linked via phosphorothioate

<220>  
<221>  modified_base
<222>  (1)..(1)
<223>  2'-O-methyl modified

<220>  
<221>  modified_base
<222>  (2)..(2)
<223>  2'-O-methyl modified

<220>  
<221>  modified_base
<222>  (3)..(3)
<223>  2'-O-methyl modified

<220>  
<221>  modified_base
<222>  (4)..(4)
<223>  2'-O-methyl modified

<220>  
<221>  modified_base
<222>  (5)..(5)
<223>  2'-O-methyl modified

<220>  
<221>  modified_base
<222>  (6)..(6)
<223>  2'-O-methyl modified

<220>  
<221>  modified_base
<222>  (7)..(7)
<223>  2'-O-methyl modified

<220>  
<221>  modified_base
<222>  (8)..(8)
<223>  2'-fluoro modified

<220>  
<221>  modified_base
<222>  (9)..(9)
<223>  2'-fluoro modified

<220>  
<221>  modified_base
<222>  (10)..(10)
<223>  2'-fluoro modified

<220>  
<221>  modified_base
<222>  (11)..(11)
<223>  2'-fluoro modified

<220>  
<221>  modified_base
<222>  (12)..(12)
<223>  2'-O-methyl modified

<220>  
<221>  modified_base
<222>  (13)..(13)
<223>  2'-O-methyl modified

<220>  
<221>  modified_base
<222>  (14)..(14)
<223>  2'-O-methyl modified

<220>  
<221>  modified_base
<222>  (15)..(15)
<223>  2'-O-methyl modified

<220>  
<221>  modified_base
<222>  (16)..(16)
<223>  2'-O-methyl modified

<220>  
<221>  modified_base
<222>  (17)..(17)
<223>  2'-O-methyl modified

<220>  
<221>  modified_base
<222>  (18)..(18)
<223>  2'-O-methyl modified

<220>  
<221>  modified_base
<222>  (19)..(19)
<223>  2'-O-methyl modified

<220>  
<221>  modified_base
<222>  (20)..(20)
<223>  2'-O-methyl modified

<220>  
<221>  modified_base
<222>  (21)..(21)
<223>  2'-O-methyl modified

<220>  
<221>  modified_base
<222>  (22)..(22)
<223>  2'-O-methyl modified

<220>  
<221>  modified_base
<222>  (23)..(23)
<223>  2'-O-methyl modified

<220>  
<221>  modified_base
<222>  (24)..(24)
<223>  2'-O-methyl modified

<220>  
<221>  modified_base
<222>  (25)..(25)
<223>  2'-O-methyl modified

<220>  
<221>  modified_base
<222>  (26)..(26)
<223>  2'-O-methyl modified

<220>  
<221>  modified_base
<222>  (27)..(27)
<223>  2'-O-methyl modified

<220>  
<221>  modified_base
<222>  (28)..(28)
<223>  GalNAc-conjugated

<220>  
<221>  modified_base
<222>  (29)..(29)
<223>  GalNAc-conjugated

<220>  
<221>  modified_base
<222>  (30)..(30)
<223>  GalNAc-conjugated

<220>  
<221>  modified_base
<222>  (31)..(31)
<223>  2'-O-methyl modified

<220>  
<221>  modified_base
<222>  (32)..(32)
<223>  2'-O-methyl modified

<220>  
<221>  modified_base
<222>  (33)..(33)
<223>  2'-O-methyl modified

<220>  
<221>  modified_base
<222>  (34)..(34)
<223>  2'-O-methyl modified

<220>  
<221>  modified_base
<222>  (35)..(35)
<223>  2'-O-methyl modified

<220>  
<221>  modified_base
<222>  (36)..(36)
<223>  2'-O-methyl modified

<400>  1025
aaguggaaca gacugagaaa gcagccgaaa ggcugc                                 36


<210>  1026
<211>  36
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  Modified sense strand


<220>
<221>  misc_feature
<222>  (1)..(2)
<223>  linked via phosphorothioate

<220>  
<221>  modified_base
<222>  (1)..(1)
<223>  2'-O-methyl modified

<220>  
<221>  modified_base
<222>  (2)..(2)
<223>  2'-O-methyl modified

<220>  
<221>  modified_base
<222>  (3)..(3)
<223>  2'-O-methyl modified

<220>  
<221>  modified_base
<222>  (4)..(4)
<223>  2'-O-methyl modified

<220>  
<221>  modified_base
<222>  (5)..(5)
<223>  2'-O-methyl modified

<220>  
<221>  modified_base
<222>  (6)..(6)
<223>  2'-O-methyl modified

<220>  
<221>  modified_base
<222>  (7)..(7)
<223>  2'-O-methyl modified

<220>  
<221>  modified_base
<222>  (8)..(8)
<223>  2'-fluoro modified

<220>  
<221>  modified_base
<222>  (9)..(9)
<223>  2'-fluoro modified

<220>  
<221>  modified_base
<222>  (10)..(10)
<223>  2'-fluoro modified

<220>  
<221>  modified_base
<222>  (11)..(11)
<223>  2'-fluoro modified

<220>  
<221>  modified_base
<222>  (12)..(12)
<223>  2'-O-methyl modified

<220>  
<221>  modified_base
<222>  (13)..(13)
<223>  2'-O-methyl modified

<220>  
<221>  modified_base
<222>  (14)..(14)
<223>  2'-O-methyl modified

<220>  
<221>  modified_base
<222>  (15)..(15)
<223>  2'-O-methyl modified

<220>  
<221>  modified_base
<222>  (16)..(16)
<223>  2'-O-methyl modified

<220>  
<221>  modified_base
<222>  (17)..(17)
<223>  2'-O-methyl modified

<220>  
<221>  modified_base
<222>  (18)..(18)
<223>  2'-O-methyl modified

<220>  
<221>  modified_base
<222>  (19)..(19)
<223>  2'-O-methyl modified

<220>  
<221>  modified_base
<222>  (20)..(20)
<223>  2'-O-methyl modified

<220>  
<221>  modified_base
<222>  (21)..(21)
<223>  2'-O-methyl modified

<220>  
<221>  modified_base
<222>  (22)..(22)
<223>  2'-O-methyl modified

<220>  
<221>  modified_base
<222>  (23)..(23)
<223>  2'-O-methyl modified

<220>  
<221>  modified_base
<222>  (24)..(24)
<223>  2'-O-methyl modified

<220>  
<221>  modified_base
<222>  (25)..(25)
<223>  2'-O-methyl modified

<220>  
<221>  modified_base
<222>  (26)..(26)
<223>  2'-O-methyl modified

<220>  
<221>  modified_base
<222>  (27)..(27)
<223>  2'-O-methyl modified

<220>  
<221>  modified_base
<222>  (28)..(28)
<223>  GalNAc-conjugated

<220>  
<221>  modified_base
<222>  (29)..(29)
<223>  GalNAc-conjugated

<220>  
<221>  modified_base
<222>  (30)..(30)
<223>  GalNAc-conjugated

<220>  
<221>  modified_base
<222>  (31)..(31)
<223>  2'-O-methyl modified

<220>  
<221>  modified_base
<222>  (32)..(32)
<223>  2'-O-methyl modified

<220>  
<221>  modified_base
<222>  (33)..(33)
<223>  2'-O-methyl modified

<220>  
<221>  modified_base
<222>  (34)..(34)
<223>  2'-O-methyl modified

<220>  
<221>  modified_base
<222>  (35)..(35)
<223>  2'-O-methyl modified

<220>  
<221>  modified_base
<222>  (36)..(36)
<223>  2'-O-methyl modified

<400>  1026
aguggaacag acugagaaga gcagccgaaa ggcugc                                 36


<210>  1027
<211>  36
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  Modified sense strand


<220>
<221>  misc_feature
<222>  (1)..(2)
<223>  linked via phosphorothioate

<220>  
<221>  modified_base
<222>  (1)..(1)
<223>  2'-O-methyl modified

<220>  
<221>  modified_base
<222>  (2)..(2)
<223>  2'-O-methyl modified

<220>  
<221>  modified_base
<222>  (3)..(3)
<223>  2'-O-methyl modified

<220>  
<221>  modified_base
<222>  (4)..(4)
<223>  2'-O-methyl modified

<220>  
<221>  modified_base
<222>  (5)..(5)
<223>  2'-O-methyl modified

<220>  
<221>  modified_base
<222>  (6)..(6)
<223>  2'-O-methyl modified

<220>  
<221>  modified_base
<222>  (7)..(7)
<223>  2'-O-methyl modified

<220>  
<221>  modified_base
<222>  (8)..(8)
<223>  2'-fluoro modified

<220>  
<221>  modified_base
<222>  (9)..(9)
<223>  2'-fluoro modified

<220>  
<221>  modified_base
<222>  (10)..(10)
<223>  2'-fluoro modified

<220>  
<221>  modified_base
<222>  (11)..(11)
<223>  2'-fluoro modified

<220>  
<221>  modified_base
<222>  (12)..(12)
<223>  2'-O-methyl modified

<220>  
<221>  modified_base
<222>  (13)..(13)
<223>  2'-O-methyl modified

<220>  
<221>  modified_base
<222>  (14)..(14)
<223>  2'-O-methyl modified

<220>  
<221>  modified_base
<222>  (15)..(15)
<223>  2'-O-methyl modified

<220>  
<221>  modified_base
<222>  (16)..(16)
<223>  2'-O-methyl modified

<220>  
<221>  modified_base
<222>  (17)..(17)
<223>  2'-O-methyl modified

<220>  
<221>  modified_base
<222>  (18)..(18)
<223>  2'-O-methyl modified

<220>  
<221>  modified_base
<222>  (19)..(19)
<223>  2'-O-methyl modified

<220>  
<221>  modified_base
<222>  (20)..(20)
<223>  2'-O-methyl modified

<220>  
<221>  modified_base
<222>  (21)..(21)
<223>  2'-O-methyl modified

<220>  
<221>  modified_base
<222>  (22)..(22)
<223>  2'-O-methyl modified

<220>  
<221>  modified_base
<222>  (23)..(23)
<223>  2'-O-methyl modified

<220>  
<221>  modified_base
<222>  (24)..(24)
<223>  2'-O-methyl modified

<220>  
<221>  modified_base
<222>  (25)..(25)
<223>  2'-O-methyl modified

<220>  
<221>  modified_base
<222>  (26)..(26)
<223>  2'-O-methyl modified

<220>  
<221>  modified_base
<222>  (27)..(27)
<223>  2'-O-methyl modified

<220>  
<221>  modified_base
<222>  (28)..(28)
<223>  GalNAc-conjugated

<220>  
<221>  modified_base
<222>  (29)..(29)
<223>  GalNAc-conjugated

<220>  
<221>  modified_base
<222>  (30)..(30)
<223>  GalNAc-conjugated

<220>  
<221>  modified_base
<222>  (31)..(31)
<223>  2'-O-methyl modified

<220>  
<221>  modified_base
<222>  (32)..(32)
<223>  2'-O-methyl modified

<220>  
<221>  modified_base
<222>  (33)..(33)
<223>  2'-O-methyl modified

<220>  
<221>  modified_base
<222>  (34)..(34)
<223>  2'-O-methyl modified

<220>  
<221>  modified_base
<222>  (35)..(35)
<223>  2'-O-methyl modified

<220>  
<221>  modified_base
<222>  (36)..(36)
<223>  2'-O-methyl modified

<400>  1027
guggaacaga cugagaagga gcagccgaaa ggcugc                                 36


<210>  1028
<211>  36
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  Modified sense strand


<220>
<221>  misc_feature
<222>  (1)..(2)
<223>  linked via phosphorothioate

<220>  
<221>  modified_base
<222>  (1)..(1)
<223>  2'-O-methyl modified

<220>  
<221>  modified_base
<222>  (2)..(2)
<223>  2'-O-methyl modified

<220>  
<221>  modified_base
<222>  (3)..(3)
<223>  2'-O-methyl modified

<220>  
<221>  modified_base
<222>  (4)..(4)
<223>  2'-O-methyl modified

<220>  
<221>  modified_base
<222>  (5)..(5)
<223>  2'-O-methyl modified

<220>  
<221>  modified_base
<222>  (6)..(6)
<223>  2'-O-methyl modified

<220>  
<221>  modified_base
<222>  (7)..(7)
<223>  2'-O-methyl modified

<220>  
<221>  modified_base
<222>  (8)..(8)
<223>  2'-fluoro modified

<220>  
<221>  modified_base
<222>  (9)..(9)
<223>  2'-fluoro modified

<220>  
<221>  modified_base
<222>  (10)..(10)
<223>  2'-fluoro modified

<220>  
<221>  modified_base
<222>  (11)..(11)
<223>  2'-fluoro modified

<220>  
<221>  modified_base
<222>  (12)..(12)
<223>  2'-O-methyl modified

<220>  
<221>  modified_base
<222>  (13)..(13)
<223>  2'-O-methyl modified

<220>  
<221>  modified_base
<222>  (14)..(14)
<223>  2'-O-methyl modified

<220>  
<221>  modified_base
<222>  (15)..(15)
<223>  2'-O-methyl modified

<220>  
<221>  modified_base
<222>  (16)..(16)
<223>  2'-O-methyl modified

<220>  
<221>  modified_base
<222>  (17)..(17)
<223>  2'-O-methyl modified

<220>  
<221>  modified_base
<222>  (18)..(18)
<223>  2'-O-methyl modified

<220>  
<221>  modified_base
<222>  (19)..(19)
<223>  2'-O-methyl modified

<220>  
<221>  modified_base
<222>  (20)..(20)
<223>  2'-O-methyl modified

<220>  
<221>  modified_base
<222>  (21)..(21)
<223>  2'-O-methyl modified

<220>  
<221>  modified_base
<222>  (22)..(22)
<223>  2'-O-methyl modified

<220>  
<221>  modified_base
<222>  (23)..(23)
<223>  2'-O-methyl modified

<220>  
<221>  modified_base
<222>  (24)..(24)
<223>  2'-O-methyl modified

<220>  
<221>  modified_base
<222>  (25)..(25)
<223>  2'-O-methyl modified

<220>  
<221>  modified_base
<222>  (26)..(26)
<223>  2'-O-methyl modified

<220>  
<221>  modified_base
<222>  (27)..(27)
<223>  2'-O-methyl modified

<220>  
<221>  modified_base
<222>  (28)..(28)
<223>  GalNAc-conjugated

<220>  
<221>  modified_base
<222>  (29)..(29)
<223>  GalNAc-conjugated

<220>  
<221>  modified_base
<222>  (30)..(30)
<223>  GalNAc-conjugated

<220>  
<221>  modified_base
<222>  (31)..(31)
<223>  2'-O-methyl modified

<220>  
<221>  modified_base
<222>  (32)..(32)
<223>  2'-O-methyl modified

<220>  
<221>  modified_base
<222>  (33)..(33)
<223>  2'-O-methyl modified

<220>  
<221>  modified_base
<222>  (34)..(34)
<223>  2'-O-methyl modified

<220>  
<221>  modified_base
<222>  (35)..(35)
<223>  2'-O-methyl modified

<220>  
<221>  modified_base
<222>  (36)..(36)
<223>  2'-O-methyl modified

<400>  1028
uggaacagac ugagaaggga gcagccgaaa ggcugc                                 36


<210>  1029
<211>  36
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  Modified sense strand


<220>
<221>  misc_feature
<222>  (1)..(2)
<223>  linked via phosphorothioate

<220>  
<221>  modified_base
<222>  (1)..(1)
<223>  2'-O-methyl modified

<220>  
<221>  modified_base
<222>  (2)..(2)
<223>  2'-O-methyl modified

<220>  
<221>  modified_base
<222>  (3)..(3)
<223>  2'-O-methyl modified

<220>  
<221>  modified_base
<222>  (4)..(4)
<223>  2'-O-methyl modified

<220>  
<221>  modified_base
<222>  (5)..(5)
<223>  2'-O-methyl modified

<220>  
<221>  modified_base
<222>  (6)..(6)
<223>  2'-O-methyl modified

<220>  
<221>  modified_base
<222>  (7)..(7)
<223>  2'-O-methyl modified

<220>  
<221>  modified_base
<222>  (8)..(8)
<223>  2'-fluoro modified

<220>  
<221>  modified_base
<222>  (9)..(9)
<223>  2'-fluoro modified

<220>  
<221>  modified_base
<222>  (10)..(10)
<223>  2'-fluoro modified

<220>  
<221>  modified_base
<222>  (11)..(11)
<223>  2'-fluoro modified

<220>  
<221>  modified_base
<222>  (12)..(12)
<223>  2'-O-methyl modified

<220>  
<221>  modified_base
<222>  (13)..(13)
<223>  2'-O-methyl modified

<220>  
<221>  modified_base
<222>  (14)..(14)
<223>  2'-O-methyl modified

<220>  
<221>  modified_base
<222>  (15)..(15)
<223>  2'-O-methyl modified

<220>  
<221>  modified_base
<222>  (16)..(16)
<223>  2'-O-methyl modified

<220>  
<221>  modified_base
<222>  (17)..(17)
<223>  2'-O-methyl modified

<220>  
<221>  modified_base
<222>  (18)..(18)
<223>  2'-O-methyl modified

<220>  
<221>  modified_base
<222>  (19)..(19)
<223>  2'-O-methyl modified

<220>  
<221>  modified_base
<222>  (20)..(20)
<223>  2'-O-methyl modified

<220>  
<221>  modified_base
<222>  (21)..(21)
<223>  2'-O-methyl modified

<220>  
<221>  modified_base
<222>  (22)..(22)
<223>  2'-O-methyl modified

<220>  
<221>  modified_base
<222>  (23)..(23)
<223>  2'-O-methyl modified

<220>  
<221>  modified_base
<222>  (24)..(24)
<223>  2'-O-methyl modified

<220>  
<221>  modified_base
<222>  (25)..(25)
<223>  2'-O-methyl modified

<220>  
<221>  modified_base
<222>  (26)..(26)
<223>  2'-O-methyl modified

<220>  
<221>  modified_base
<222>  (27)..(27)
<223>  2'-O-methyl modified

<220>  
<221>  modified_base
<222>  (28)..(28)
<223>  GalNAc-conjugated

<220>  
<221>  modified_base
<222>  (29)..(29)
<223>  GalNAc-conjugated

<220>  
<221>  modified_base
<222>  (30)..(30)
<223>  GalNAc-conjugated

<220>  
<221>  modified_base
<222>  (31)..(31)
<223>  2'-O-methyl modified

<220>  
<221>  modified_base
<222>  (32)..(32)
<223>  2'-O-methyl modified

<220>  
<221>  modified_base
<222>  (33)..(33)
<223>  2'-O-methyl modified

<220>  
<221>  modified_base
<222>  (34)..(34)
<223>  2'-O-methyl modified

<220>  
<221>  modified_base
<222>  (35)..(35)
<223>  2'-O-methyl modified

<220>  
<221>  modified_base
<222>  (36)..(36)
<223>  2'-O-methyl modified

<400>  1029
gaacagacug agaagggcaa gcagccgaaa ggcugc                                 36


<210>  1030
<211>  36
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  Modified sense strand


<220>
<221>  misc_feature
<222>  (1)..(2)
<223>  linked via phosphorothioate

<220>  
<221>  modified_base
<222>  (1)..(1)
<223>  2'-O-methyl modified

<220>  
<221>  modified_base
<222>  (2)..(2)
<223>  2'-O-methyl modified

<220>  
<221>  modified_base
<222>  (3)..(3)
<223>  2'-O-methyl modified

<220>  
<221>  modified_base
<222>  (4)..(4)
<223>  2'-O-methyl modified

<220>  
<221>  modified_base
<222>  (5)..(5)
<223>  2'-O-methyl modified

<220>  
<221>  modified_base
<222>  (6)..(6)
<223>  2'-O-methyl modified

<220>  
<221>  modified_base
<222>  (7)..(7)
<223>  2'-O-methyl modified

<220>  
<221>  modified_base
<222>  (8)..(8)
<223>  2'-fluoro modified

<220>  
<221>  modified_base
<222>  (9)..(9)
<223>  2'-fluoro modified

<220>  
<221>  modified_base
<222>  (10)..(10)
<223>  2'-fluoro modified

<220>  
<221>  modified_base
<222>  (11)..(11)
<223>  2'-fluoro modified

<220>  
<221>  modified_base
<222>  (12)..(12)
<223>  2'-O-methyl modified

<220>  
<221>  modified_base
<222>  (13)..(13)
<223>  2'-O-methyl modified

<220>  
<221>  modified_base
<222>  (14)..(14)
<223>  2'-O-methyl modified

<220>  
<221>  modified_base
<222>  (15)..(15)
<223>  2'-O-methyl modified

<220>  
<221>  modified_base
<222>  (16)..(16)
<223>  2'-O-methyl modified

<220>  
<221>  modified_base
<222>  (17)..(17)
<223>  2'-O-methyl modified

<220>  
<221>  modified_base
<222>  (18)..(18)
<223>  2'-O-methyl modified

<220>  
<221>  modified_base
<222>  (19)..(19)
<223>  2'-O-methyl modified

<220>  
<221>  modified_base
<222>  (20)..(20)
<223>  2'-O-methyl modified

<220>  
<221>  modified_base
<222>  (21)..(21)
<223>  2'-O-methyl modified

<220>  
<221>  modified_base
<222>  (22)..(22)
<223>  2'-O-methyl modified

<220>  
<221>  modified_base
<222>  (23)..(23)
<223>  2'-O-methyl modified

<220>  
<221>  modified_base
<222>  (24)..(24)
<223>  2'-O-methyl modified

<220>  
<221>  modified_base
<222>  (25)..(25)
<223>  2'-O-methyl modified

<220>  
<221>  modified_base
<222>  (26)..(26)
<223>  2'-O-methyl modified

<220>  
<221>  modified_base
<222>  (27)..(27)
<223>  2'-O-methyl modified

<220>  
<221>  modified_base
<222>  (28)..(28)
<223>  GalNAc-conjugated

<220>  
<221>  modified_base
<222>  (29)..(29)
<223>  GalNAc-conjugated

<220>  
<221>  modified_base
<222>  (30)..(30)
<223>  GalNAc-conjugated

<220>  
<221>  modified_base
<222>  (31)..(31)
<223>  2'-O-methyl modified

<220>  
<221>  modified_base
<222>  (32)..(32)
<223>  2'-O-methyl modified

<220>  
<221>  modified_base
<222>  (33)..(33)
<223>  2'-O-methyl modified

<220>  
<221>  modified_base
<222>  (34)..(34)
<223>  2'-O-methyl modified

<220>  
<221>  modified_base
<222>  (35)..(35)
<223>  2'-O-methyl modified

<220>  
<221>  modified_base
<222>  (36)..(36)
<223>  2'-O-methyl modified

<400>  1030
acugagaagg gcaaacauua gcagccgaaa ggcugc                                 36


<210>  1031
<211>  36
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  Modified sense strand


<220>
<221>  misc_feature
<222>  (1)..(2)
<223>  linked via phosphorothioate

<220>  
<221>  modified_base
<222>  (1)..(1)
<223>  2'-O-methyl modified

<220>  
<221>  modified_base
<222>  (2)..(2)
<223>  2'-O-methyl modified

<220>  
<221>  modified_base
<222>  (3)..(3)
<223>  2'-O-methyl modified

<220>  
<221>  modified_base
<222>  (4)..(4)
<223>  2'-O-methyl modified

<220>  
<221>  modified_base
<222>  (5)..(5)
<223>  2'-O-methyl modified

<220>  
<221>  modified_base
<222>  (6)..(6)
<223>  2'-O-methyl modified

<220>  
<221>  modified_base
<222>  (7)..(7)
<223>  2'-O-methyl modified

<220>  
<221>  modified_base
<222>  (8)..(8)
<223>  2'-fluoro modified

<220>  
<221>  modified_base
<222>  (9)..(9)
<223>  2'-fluoro modified

<220>  
<221>  modified_base
<222>  (10)..(10)
<223>  2'-fluoro modified

<220>  
<221>  modified_base
<222>  (11)..(11)
<223>  2'-fluoro modified

<220>  
<221>  modified_base
<222>  (12)..(12)
<223>  2'-O-methyl modified

<220>  
<221>  modified_base
<222>  (13)..(13)
<223>  2'-O-methyl modified

<220>  
<221>  modified_base
<222>  (14)..(14)
<223>  2'-O-methyl modified

<220>  
<221>  modified_base
<222>  (15)..(15)
<223>  2'-O-methyl modified

<220>  
<221>  modified_base
<222>  (16)..(16)
<223>  2'-O-methyl modified

<220>  
<221>  modified_base
<222>  (17)..(17)
<223>  2'-O-methyl modified

<220>  
<221>  modified_base
<222>  (18)..(18)
<223>  2'-O-methyl modified

<220>  
<221>  modified_base
<222>  (19)..(19)
<223>  2'-O-methyl modified

<220>  
<221>  modified_base
<222>  (20)..(20)
<223>  2'-O-methyl modified

<220>  
<221>  modified_base
<222>  (21)..(21)
<223>  2'-O-methyl modified

<220>  
<221>  modified_base
<222>  (22)..(22)
<223>  2'-O-methyl modified

<220>  
<221>  modified_base
<222>  (23)..(23)
<223>  2'-O-methyl modified

<220>  
<221>  modified_base
<222>  (24)..(24)
<223>  2'-O-methyl modified

<220>  
<221>  modified_base
<222>  (25)..(25)
<223>  2'-O-methyl modified

<220>  
<221>  modified_base
<222>  (26)..(26)
<223>  2'-O-methyl modified

<220>  
<221>  modified_base
<222>  (27)..(27)
<223>  2'-O-methyl modified

<220>  
<221>  modified_base
<222>  (28)..(28)
<223>  GalNAc-conjugated

<220>  
<221>  modified_base
<222>  (29)..(29)
<223>  GalNAc-conjugated

<220>  
<221>  modified_base
<222>  (30)..(30)
<223>  GalNAc-conjugated

<220>  
<221>  modified_base
<222>  (31)..(31)
<223>  2'-O-methyl modified

<220>  
<221>  modified_base
<222>  (32)..(32)
<223>  2'-O-methyl modified

<220>  
<221>  modified_base
<222>  (33)..(33)
<223>  2'-O-methyl modified

<220>  
<221>  modified_base
<222>  (34)..(34)
<223>  2'-O-methyl modified

<220>  
<221>  modified_base
<222>  (35)..(35)
<223>  2'-O-methyl modified

<220>  
<221>  modified_base
<222>  (36)..(36)
<223>  2'-O-methyl modified

<400>  1031
guggcauuaa aagagaguca gcagccgaaa ggcugc                                 36


<210>  1032
<211>  36
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  Modified sense strand


<220>
<221>  misc_feature
<222>  (1)..(2)
<223>  linked via phosphorothioate

<220>  
<221>  modified_base
<222>  (1)..(1)
<223>  2'-O-methyl modified

<220>  
<221>  modified_base
<222>  (2)..(2)
<223>  2'-O-methyl modified

<220>  
<221>  modified_base
<222>  (3)..(3)
<223>  2'-O-methyl modified

<220>  
<221>  modified_base
<222>  (4)..(4)
<223>  2'-O-methyl modified

<220>  
<221>  modified_base
<222>  (5)..(5)
<223>  2'-O-methyl modified

<220>  
<221>  modified_base
<222>  (6)..(6)
<223>  2'-O-methyl modified

<220>  
<221>  modified_base
<222>  (7)..(7)
<223>  2'-O-methyl modified

<220>  
<221>  modified_base
<222>  (8)..(8)
<223>  2'-fluoro modified

<220>  
<221>  modified_base
<222>  (9)..(9)
<223>  2'-fluoro modified

<220>  
<221>  modified_base
<222>  (10)..(10)
<223>  2'-fluoro modified

<220>  
<221>  modified_base
<222>  (11)..(11)
<223>  2'-fluoro modified

<220>  
<221>  modified_base
<222>  (12)..(12)
<223>  2'-O-methyl modified

<220>  
<221>  modified_base
<222>  (13)..(13)
<223>  2'-O-methyl modified

<220>  
<221>  modified_base
<222>  (14)..(14)
<223>  2'-O-methyl modified

<220>  
<221>  modified_base
<222>  (15)..(15)
<223>  2'-O-methyl modified

<220>  
<221>  modified_base
<222>  (16)..(16)
<223>  2'-O-methyl modified

<220>  
<221>  modified_base
<222>  (17)..(17)
<223>  2'-O-methyl modified

<220>  
<221>  modified_base
<222>  (18)..(18)
<223>  2'-O-methyl modified

<220>  
<221>  modified_base
<222>  (19)..(19)
<223>  2'-O-methyl modified

<220>  
<221>  modified_base
<222>  (20)..(20)
<223>  2'-O-methyl modified

<220>  
<221>  modified_base
<222>  (21)..(21)
<223>  2'-O-methyl modified

<220>  
<221>  modified_base
<222>  (22)..(22)
<223>  2'-O-methyl modified

<220>  
<221>  modified_base
<222>  (23)..(23)
<223>  2'-O-methyl modified

<220>  
<221>  modified_base
<222>  (24)..(24)
<223>  2'-O-methyl modified

<220>  
<221>  modified_base
<222>  (25)..(25)
<223>  2'-O-methyl modified

<220>  
<221>  modified_base
<222>  (26)..(26)
<223>  2'-O-methyl modified

<220>  
<221>  modified_base
<222>  (27)..(27)
<223>  2'-O-methyl modified

<220>  
<221>  modified_base
<222>  (28)..(28)
<223>  GalNAc-conjugated

<220>  
<221>  modified_base
<222>  (29)..(29)
<223>  GalNAc-conjugated

<220>  
<221>  modified_base
<222>  (30)..(30)
<223>  GalNAc-conjugated

<220>  
<221>  modified_base
<222>  (31)..(31)
<223>  2'-O-methyl modified

<220>  
<221>  modified_base
<222>  (32)..(32)
<223>  2'-O-methyl modified

<220>  
<221>  modified_base
<222>  (33)..(33)
<223>  2'-O-methyl modified

<220>  
<221>  modified_base
<222>  (34)..(34)
<223>  2'-O-methyl modified

<220>  
<221>  modified_base
<222>  (35)..(35)
<223>  2'-O-methyl modified

<220>  
<221>  modified_base
<222>  (36)..(36)
<223>  2'-O-methyl modified

<400>  1032
uggcauuaaa agagagucaa gcagccgaaa ggcugc                                 36


<210>  1033
<211>  22
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  Modified antisense strand


<220>
<221>  misc_feature
<222>  (1)..(4)
<223>  linked via phosphorothioate

<220>  
<221>  modified_base
<222>  (1)..(1)
<223>  5'-methoxyphosphonate-4-oxy modified

<220>  
<221>  modified_base
<222>  (2)..(2)
<223>  2'-fluoro modified

<220>  
<221>  modified_base
<222>  (3)..(3)
<223>  2'-fluoro modified

<220>  
<221>  modified_base
<222>  (4)..(4)
<223>  2'-fluoro modified

<220>  
<221>  modified_base
<222>  (5)..(5)
<223>  2'-fluoro modified

<220>  
<221>  modified_base
<222>  (6)..(6)
<223>  2'-O-methyl modified

<220>  
<221>  modified_base
<222>  (7)..(7)
<223>  2'-fluoro modified

<220>  
<221>  modified_base
<222>  (8)..(8)
<223>  2'-O-methyl modified

<220>  
<221>  modified_base
<222>  (9)..(9)
<223>  2'-O-methyl modified

<220>  
<221>  modified_base
<222>  (10)..(10)
<223>  2'-fluoro modified

<220>  
<221>  modified_base
<222>  (11)..(11)
<223>  2'-O-methyl modified

<220>  
<221>  modified_base
<222>  (12)..(12)
<223>  2'-O-methyl modified

<220>  
<221>  modified_base
<222>  (13)..(13)
<223>  2'-O-methyl modified

<220>  
<221>  modified_base
<222>  (14)..(14)
<223>  2'-fluoro modified

<220>  
<221>  modified_base
<222>  (15)..(15)
<223>  2'-O-methyl modified

<220>  
<221>  modified_base
<222>  (16)..(16)
<223>  2'-O-methyl modified

<220>  
<221>  modified_base
<222>  (17)..(17)
<223>  2'-O-methyl modified

<220>  
<221>  modified_base
<222>  (18)..(18)
<223>  2'-O-methyl modified

<220>  
<221>  modified_base
<222>  (19)..(19)
<223>  2'-O-methyl modified

<220>
<221>  misc_feature
<222>  (20)..(22)
<223>  linked via phosphorothioate

<220>  
<221>  modified_base
<222>  (20)..(20)
<223>  2'-O-methyl modified

<220>  
<221>  modified_base
<222>  (21)..(21)
<223>  2'-O-methyl modified

<220>  
<221>  modified_base
<222>  (22)..(22)
<223>  2'-O-methyl modified

<400>  1033
uuguucuucu gacaggacac gg                                                22


<210>  1034
<211>  22
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  Modified antisense strand


<220>
<221>  misc_feature
<222>  (1)..(4)
<223>  linked via phosphorothioate

<220>  
<221>  modified_base
<222>  (1)..(1)
<223>  5'-methoxyphosphonate-4-oxy modified

<220>  
<221>  modified_base
<222>  (2)..(2)
<223>  2'-fluoro modified

<220>  
<221>  modified_base
<222>  (3)..(3)
<223>  2'-fluoro modified

<220>  
<221>  modified_base
<222>  (4)..(4)
<223>  2'-fluoro modified

<220>  
<221>  modified_base
<222>  (5)..(5)
<223>  2'-fluoro modified

<220>  
<221>  modified_base
<222>  (6)..(6)
<223>  2'-O-methyl modified

<220>  
<221>  modified_base
<222>  (7)..(7)
<223>  2'-fluoro modified

<220>  
<221>  modified_base
<222>  (8)..(8)
<223>  2'-O-methyl modified

<220>  
<221>  modified_base
<222>  (9)..(9)
<223>  2'-O-methyl modified

<220>  
<221>  modified_base
<222>  (10)..(10)
<223>  2'-fluoro modified

<220>  
<221>  modified_base
<222>  (11)..(11)
<223>  2'-O-methyl modified

<220>  
<221>  modified_base
<222>  (12)..(12)
<223>  2'-O-methyl modified

<220>  
<221>  modified_base
<222>  (13)..(13)
<223>  2'-O-methyl modified

<220>  
<221>  modified_base
<222>  (14)..(14)
<223>  2'-fluoro modified

<220>  
<221>  modified_base
<222>  (15)..(15)
<223>  2'-O-methyl modified

<220>  
<221>  modified_base
<222>  (16)..(16)
<223>  2'-O-methyl modified

<220>  
<221>  modified_base
<222>  (17)..(17)
<223>  2'-O-methyl modified

<220>  
<221>  modified_base
<222>  (18)..(18)
<223>  2'-O-methyl modified

<220>  
<221>  modified_base
<222>  (19)..(19)
<223>  2'-O-methyl modified

<220>
<221>  misc_feature
<222>  (20)..(22)
<223>  linked via phosphorothioate

<220>  
<221>  modified_base
<222>  (20)..(20)
<223>  2'-O-methyl modified

<220>  
<221>  modified_base
<222>  (21)..(21)
<223>  2'-O-methyl modified

<220>  
<221>  modified_base
<222>  (22)..(22)
<223>  2'-O-methyl modified

<400>  1034
uucuguucuu cugacaggac gg                                                22


<210>  1035
<211>  22
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  Modified antisense strand


<220>
<221>  misc_feature
<222>  (1)..(4)
<223>  linked via phosphorothioate

<220>  
<221>  modified_base
<222>  (1)..(1)
<223>  5'-methoxyphosphonate-4-oxy modified

<220>  
<221>  modified_base
<222>  (2)..(2)
<223>  2'-fluoro modified

<220>  
<221>  modified_base
<222>  (3)..(3)
<223>  2'-fluoro modified

<220>  
<221>  modified_base
<222>  (4)..(4)
<223>  2'-fluoro modified

<220>  
<221>  modified_base
<222>  (5)..(5)
<223>  2'-fluoro modified

<220>  
<221>  modified_base
<222>  (6)..(6)
<223>  2'-O-methyl modified

<220>  
<221>  modified_base
<222>  (7)..(7)
<223>  2'-fluoro modified

<220>  
<221>  modified_base
<222>  (8)..(8)
<223>  2'-O-methyl modified

<220>  
<221>  modified_base
<222>  (9)..(9)
<223>  2'-O-methyl modified

<220>  
<221>  modified_base
<222>  (10)..(10)
<223>  2'-fluoro modified

<220>  
<221>  modified_base
<222>  (11)..(11)
<223>  2'-O-methyl modified

<220>  
<221>  modified_base
<222>  (12)..(12)
<223>  2'-O-methyl modified

<220>  
<221>  modified_base
<222>  (13)..(13)
<223>  2'-O-methyl modified

<220>  
<221>  modified_base
<222>  (14)..(14)
<223>  2'-fluoro modified

<220>  
<221>  modified_base
<222>  (15)..(15)
<223>  2'-O-methyl modified

<220>  
<221>  modified_base
<222>  (16)..(16)
<223>  2'-O-methyl modified

<220>  
<221>  modified_base
<222>  (17)..(17)
<223>  2'-O-methyl modified

<220>  
<221>  modified_base
<222>  (18)..(18)
<223>  2'-O-methyl modified

<220>  
<221>  modified_base
<222>  (19)..(19)
<223>  2'-O-methyl modified

<220>
<221>  misc_feature
<222>  (20)..(22)
<223>  linked via phosphorothioate

<220>  
<221>  modified_base
<222>  (20)..(20)
<223>  2'-O-methyl modified

<220>  
<221>  modified_base
<222>  (21)..(21)
<223>  2'-O-methyl modified

<220>  
<221>  modified_base
<222>  (22)..(22)
<223>  2'-O-methyl modified

<400>  1035
ugaucuguuc uucugacagg gg                                                22


<210>  1036
<211>  22
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  Modified antisense strand


<220>
<221>  misc_feature
<222>  (1)..(4)
<223>  linked via phosphorothioate

<220>  
<221>  modified_base
<222>  (1)..(1)
<223>  5'-methoxyphosphonate-4-oxy modified

<220>  
<221>  modified_base
<222>  (2)..(2)
<223>  2'-fluoro modified

<220>  
<221>  modified_base
<222>  (3)..(3)
<223>  2'-fluoro modified

<220>  
<221>  modified_base
<222>  (4)..(4)
<223>  2'-fluoro modified

<220>  
<221>  modified_base
<222>  (5)..(5)
<223>  2'-fluoro modified

<220>  
<221>  modified_base
<222>  (6)..(6)
<223>  2'-O-methyl modified

<220>  
<221>  modified_base
<222>  (7)..(7)
<223>  2'-fluoro modified

<220>  
<221>  modified_base
<222>  (8)..(8)
<223>  2'-O-methyl modified

<220>  
<221>  modified_base
<222>  (9)..(9)
<223>  2'-O-methyl modified

<220>  
<221>  modified_base
<222>  (10)..(10)
<223>  2'-fluoro modified

<220>  
<221>  modified_base
<222>  (11)..(11)
<223>  2'-O-methyl modified

<220>  
<221>  modified_base
<222>  (12)..(12)
<223>  2'-O-methyl modified

<220>  
<221>  modified_base
<222>  (13)..(13)
<223>  2'-O-methyl modified

<220>  
<221>  modified_base
<222>  (14)..(14)
<223>  2'-fluoro modified

<220>  
<221>  modified_base
<222>  (15)..(15)
<223>  2'-O-methyl modified

<220>  
<221>  modified_base
<222>  (16)..(16)
<223>  2'-O-methyl modified

<220>  
<221>  modified_base
<222>  (17)..(17)
<223>  2'-O-methyl modified

<220>  
<221>  modified_base
<222>  (18)..(18)
<223>  2'-O-methyl modified

<220>  
<221>  modified_base
<222>  (19)..(19)
<223>  2'-O-methyl modified

<220>
<221>  misc_feature
<222>  (20)..(22)
<223>  linked via phosphorothioate

<220>  
<221>  modified_base
<222>  (20)..(20)
<223>  2'-O-methyl modified

<220>  
<221>  modified_base
<222>  (21)..(21)
<223>  2'-O-methyl modified

<220>  
<221>  modified_base
<222>  (22)..(22)
<223>  2'-O-methyl modified

<400>  1036
uggaucuguu cuucugacag gg                                                22


<210>  1037
<211>  22
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  Modified antisense strand


<220>
<221>  misc_feature
<222>  (1)..(3)
<223>  linked via phosphorothioate

<220>  
<221>  modified_base
<222>  (1)..(1)
<223>  5'-methoxyphosphonate-4-oxy modified

<220>  
<221>  modified_base
<222>  (2)..(2)
<223>  2'-fluoro modified

<220>  
<221>  modified_base
<222>  (3)..(3)
<223>  2'-fluoro modified

<220>  
<221>  modified_base
<222>  (4)..(4)
<223>  2'-O-methyl modified

<220>  
<221>  modified_base
<222>  (5)..(5)
<223>  2'-fluoro modified

<220>  
<221>  modified_base
<222>  (6)..(6)
<223>  2'-O-methyl modified

<220>  
<221>  modified_base
<222>  (7)..(7)
<223>  2'-fluoro modified

<220>  
<221>  modified_base
<222>  (8)..(8)
<223>  2'-O-methyl modified

<220>  
<221>  modified_base
<222>  (9)..(9)
<223>  2'-O-methyl modified

<220>  
<221>  modified_base
<222>  (10)..(10)
<223>  2'-fluoro modified

<220>  
<221>  modified_base
<222>  (11)..(11)
<223>  2'-O-methyl modified

<220>  
<221>  modified_base
<222>  (12)..(12)
<223>  2'-O-methyl modified

<220>  
<221>  modified_base
<222>  (13)..(13)
<223>  2'-O-methyl modified

<220>  
<221>  modified_base
<222>  (14)..(14)
<223>  2'-fluoro modified

<220>  
<221>  modified_base
<222>  (15)..(15)
<223>  2'-O-methyl modified

<220>  
<221>  modified_base
<222>  (16)..(16)
<223>  2'-O-methyl modified

<220>  
<221>  modified_base
<222>  (17)..(17)
<223>  2'-O-methyl modified

<220>  
<221>  modified_base
<222>  (18)..(18)
<223>  2'-O-methyl modified

<220>  
<221>  modified_base
<222>  (19)..(19)
<223>  2'-O-methyl modified

<220>
<221>  misc_feature
<222>  (20)..(22)
<223>  linked via phosphorothioate

<220>  
<221>  modified_base
<222>  (20)..(20)
<223>  2'-O-methyl modified

<220>  
<221>  modified_base
<222>  (21)..(21)
<223>  2'-O-methyl modified

<220>  
<221>  modified_base
<222>  (22)..(22)
<223>  2'-O-methyl modified

<400>  1037
ucggaucugu ucuucugaca gg                                                22


<210>  1038
<211>  22
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  Modified antisense strand


<220>
<221>  misc_feature
<222>  (1)..(4)
<223>  linked via phosphorothioate

<220>  
<221>  modified_base
<222>  (1)..(1)
<223>  5'-methoxyphosphonate-4-oxy modified

<220>  
<221>  modified_base
<222>  (2)..(2)
<223>  2'-fluoro modified

<220>  
<221>  modified_base
<222>  (3)..(3)
<223>  2'-fluoro modified

<220>  
<221>  modified_base
<222>  (4)..(4)
<223>  2'-fluoro modified

<220>  
<221>  modified_base
<222>  (5)..(5)
<223>  2'-fluoro modified

<220>  
<221>  modified_base
<222>  (6)..(6)
<223>  2'-O-methyl modified

<220>  
<221>  modified_base
<222>  (7)..(7)
<223>  2'-fluoro modified

<220>  
<221>  modified_base
<222>  (8)..(8)
<223>  2'-O-methyl modified

<220>  
<221>  modified_base
<222>  (9)..(9)
<223>  2'-O-methyl modified

<220>  
<221>  modified_base
<222>  (10)..(10)
<223>  2'-fluoro modified

<220>  
<221>  modified_base
<222>  (11)..(11)
<223>  2'-O-methyl modified

<220>  
<221>  modified_base
<222>  (12)..(12)
<223>  2'-O-methyl modified

<220>  
<221>  modified_base
<222>  (13)..(13)
<223>  2'-O-methyl modified

<220>  
<221>  modified_base
<222>  (14)..(14)
<223>  2'-fluoro modified

<220>  
<221>  modified_base
<222>  (15)..(15)
<223>  2'-O-methyl modified

<220>  
<221>  modified_base
<222>  (16)..(16)
<223>  2'-O-methyl modified

<220>  
<221>  modified_base
<222>  (17)..(17)
<223>  2'-O-methyl modified

<220>  
<221>  modified_base
<222>  (18)..(18)
<223>  2'-O-methyl modified

<220>  
<221>  modified_base
<222>  (19)..(19)
<223>  2'-O-methyl modified

<220>
<221>  misc_feature
<222>  (20)..(22)
<223>  linked via phosphorothioate

<220>  
<221>  modified_base
<222>  (20)..(20)
<223>  2'-O-methyl modified

<220>  
<221>  modified_base
<222>  (21)..(21)
<223>  2'-O-methyl modified

<220>  
<221>  modified_base
<222>  (22)..(22)
<223>  2'-O-methyl modified

<400>  1038
ucucuugccg cuucaguuuc gg                                                22


<210>  1039
<211>  22
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  Modified antisense strand


<220>
<221>  misc_feature
<222>  (1)..(4)
<223>  linked via phosphorothioate

<220>  
<221>  modified_base
<222>  (1)..(1)
<223>  5'-methoxyphosphonate-4-oxy modified

<220>  
<221>  modified_base
<222>  (2)..(2)
<223>  2'-fluoro modified

<220>  
<221>  modified_base
<222>  (3)..(3)
<223>  2'-fluoro modified

<220>  
<221>  modified_base
<222>  (4)..(4)
<223>  2'-fluoro modified

<220>  
<221>  modified_base
<222>  (5)..(5)
<223>  2'-fluoro modified

<220>  
<221>  modified_base
<222>  (6)..(6)
<223>  2'-O-methyl modified

<220>  
<221>  modified_base
<222>  (7)..(7)
<223>  2'-fluoro modified

<220>  
<221>  modified_base
<222>  (8)..(8)
<223>  2'-O-methyl modified

<220>  
<221>  modified_base
<222>  (9)..(9)
<223>  2'-O-methyl modified

<220>  
<221>  modified_base
<222>  (10)..(10)
<223>  2'-fluoro modified

<220>  
<221>  modified_base
<222>  (11)..(11)
<223>  2'-O-methyl modified

<220>  
<221>  modified_base
<222>  (12)..(12)
<223>  2'-O-methyl modified

<220>  
<221>  modified_base
<222>  (13)..(13)
<223>  2'-O-methyl modified

<220>  
<221>  modified_base
<222>  (14)..(14)
<223>  2'-fluoro modified

<220>  
<221>  modified_base
<222>  (15)..(15)
<223>  2'-O-methyl modified

<220>  
<221>  modified_base
<222>  (16)..(16)
<223>  2'-O-methyl modified

<220>  
<221>  modified_base
<222>  (17)..(17)
<223>  2'-O-methyl modified

<220>  
<221>  modified_base
<222>  (18)..(18)
<223>  2'-O-methyl modified

<220>  
<221>  modified_base
<222>  (19)..(19)
<223>  2'-O-methyl modified

<220>
<221>  misc_feature
<222>  (20)..(22)
<223>  linked via phosphorothioate

<220>  
<221>  modified_base
<222>  (20)..(20)
<223>  2'-O-methyl modified

<220>  
<221>  modified_base
<222>  (21)..(21)
<223>  2'-O-methyl modified

<220>  
<221>  modified_base
<222>  (22)..(22)
<223>  2'-O-methyl modified

<400>  1039
uaugucucca gaagcaucac gg                                                22


<210>  1040
<211>  22
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  Modified antisense strand


<220>
<221>  misc_feature
<222>  (1)..(4)
<223>  linked via phosphorothioate

<220>  
<221>  modified_base
<222>  (1)..(1)
<223>  5'-methoxyphosphonate-4-oxy modified

<220>  
<221>  modified_base
<222>  (2)..(2)
<223>  2'-fluoro modified

<220>  
<221>  modified_base
<222>  (3)..(3)
<223>  2'-fluoro modified

<220>  
<221>  modified_base
<222>  (4)..(4)
<223>  2'-fluoro modified

<220>  
<221>  modified_base
<222>  (5)..(5)
<223>  2'-fluoro modified

<220>  
<221>  modified_base
<222>  (6)..(6)
<223>  2'-O-methyl modified

<220>  
<221>  modified_base
<222>  (7)..(7)
<223>  2'-fluoro modified

<220>  
<221>  modified_base
<222>  (8)..(8)
<223>  2'-O-methyl modified

<220>  
<221>  modified_base
<222>  (9)..(9)
<223>  2'-O-methyl modified

<220>  
<221>  modified_base
<222>  (10)..(10)
<223>  2'-fluoro modified

<220>  
<221>  modified_base
<222>  (11)..(11)
<223>  2'-O-methyl modified

<220>  
<221>  modified_base
<222>  (12)..(12)
<223>  2'-O-methyl modified

<220>  
<221>  modified_base
<222>  (13)..(13)
<223>  2'-O-methyl modified

<220>  
<221>  modified_base
<222>  (14)..(14)
<223>  2'-fluoro modified

<220>  
<221>  modified_base
<222>  (15)..(15)
<223>  2'-O-methyl modified

<220>  
<221>  modified_base
<222>  (16)..(16)
<223>  2'-O-methyl modified

<220>  
<221>  modified_base
<222>  (17)..(17)
<223>  2'-O-methyl modified

<220>  
<221>  modified_base
<222>  (18)..(18)
<223>  2'-O-methyl modified

<220>  
<221>  modified_base
<222>  (19)..(19)
<223>  2'-O-methyl modified

<220>
<221>  misc_feature
<222>  (20)..(22)
<223>  linked via phosphorothioate

<220>  
<221>  modified_base
<222>  (20)..(20)
<223>  2'-O-methyl modified

<220>  
<221>  modified_base
<222>  (21)..(21)
<223>  2'-O-methyl modified

<220>  
<221>  modified_base
<222>  (22)..(22)
<223>  2'-O-methyl modified

<400>  1040
uaaggugaua cucucacucc gg                                                22


<210>  1041
<211>  22
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  Modified antisense strand


<220>
<221>  misc_feature
<222>  (1)..(4)
<223>  linked via phosphorothioate

<220>  
<221>  modified_base
<222>  (1)..(1)
<223>  5'-methoxyphosphonate-4-oxy modified

<220>  
<221>  modified_base
<222>  (2)..(2)
<223>  2'-fluoro modified

<220>  
<221>  modified_base
<222>  (3)..(3)
<223>  2'-fluoro modified

<220>  
<221>  modified_base
<222>  (4)..(4)
<223>  2'-fluoro modified

<220>  
<221>  modified_base
<222>  (5)..(5)
<223>  2'-fluoro modified

<220>  
<221>  modified_base
<222>  (6)..(6)
<223>  2'-O-methyl modified

<220>  
<221>  modified_base
<222>  (7)..(7)
<223>  2'-fluoro modified

<220>  
<221>  modified_base
<222>  (8)..(8)
<223>  2'-O-methyl modified

<220>  
<221>  modified_base
<222>  (9)..(9)
<223>  2'-O-methyl modified

<220>  
<221>  modified_base
<222>  (10)..(10)
<223>  2'-fluoro modified

<220>  
<221>  modified_base
<222>  (11)..(11)
<223>  2'-O-methyl modified

<220>  
<221>  modified_base
<222>  (12)..(12)
<223>  2'-O-methyl modified

<220>  
<221>  modified_base
<222>  (13)..(13)
<223>  2'-O-methyl modified

<220>  
<221>  modified_base
<222>  (14)..(14)
<223>  2'-fluoro modified

<220>  
<221>  modified_base
<222>  (15)..(15)
<223>  2'-O-methyl modified

<220>  
<221>  modified_base
<222>  (16)..(16)
<223>  2'-O-methyl modified

<220>  
<221>  modified_base
<222>  (17)..(17)
<223>  2'-O-methyl modified

<220>  
<221>  modified_base
<222>  (18)..(18)
<223>  2'-O-methyl modified

<220>  
<221>  modified_base
<222>  (19)..(19)
<223>  2'-O-methyl modified

<220>
<221>  misc_feature
<222>  (20)..(22)
<223>  linked via phosphorothioate

<220>  
<221>  modified_base
<222>  (20)..(20)
<223>  2'-O-methyl modified

<220>  
<221>  modified_base
<222>  (21)..(21)
<223>  2'-O-methyl modified

<220>  
<221>  modified_base
<222>  (22)..(22)
<223>  2'-O-methyl modified

<400>  1041
uuugaggaag gugauacucu gg                                                22


<210>  1042
<211>  22
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  Modified antisense strand


<220>
<221>  misc_feature
<222>  (1)..(4)
<223>  linked via phosphorothioate

<220>  
<221>  modified_base
<222>  (1)..(1)
<223>  5'-methoxyphosphonate-4-oxy modified

<220>  
<221>  modified_base
<222>  (2)..(2)
<223>  2'-fluoro modified

<220>  
<221>  modified_base
<222>  (3)..(3)
<223>  2'-fluoro modified

<220>  
<221>  modified_base
<222>  (4)..(4)
<223>  2'-fluoro modified

<220>  
<221>  modified_base
<222>  (5)..(5)
<223>  2'-fluoro modified

<220>  
<221>  modified_base
<222>  (6)..(6)
<223>  2'-O-methyl modified

<220>  
<221>  modified_base
<222>  (7)..(7)
<223>  2'-fluoro modified

<220>  
<221>  modified_base
<222>  (8)..(8)
<223>  2'-O-methyl modified

<220>  
<221>  modified_base
<222>  (9)..(9)
<223>  2'-O-methyl modified

<220>  
<221>  modified_base
<222>  (10)..(10)
<223>  2'-fluoro modified

<220>  
<221>  modified_base
<222>  (11)..(11)
<223>  2'-O-methyl modified

<220>  
<221>  modified_base
<222>  (12)..(12)
<223>  2'-O-methyl modified

<220>  
<221>  modified_base
<222>  (13)..(13)
<223>  2'-O-methyl modified

<220>  
<221>  modified_base
<222>  (14)..(14)
<223>  2'-fluoro modified

<220>  
<221>  modified_base
<222>  (15)..(15)
<223>  2'-O-methyl modified

<220>  
<221>  modified_base
<222>  (16)..(16)
<223>  2'-O-methyl modified

<220>  
<221>  modified_base
<222>  (17)..(17)
<223>  2'-O-methyl modified

<220>  
<221>  modified_base
<222>  (18)..(18)
<223>  2'-O-methyl modified

<220>  
<221>  modified_base
<222>  (19)..(19)
<223>  2'-O-methyl modified

<220>
<221>  misc_feature
<222>  (20)..(22)
<223>  linked via phosphorothioate

<220>  
<221>  modified_base
<222>  (20)..(20)
<223>  2'-O-methyl modified

<220>  
<221>  modified_base
<222>  (21)..(21)
<223>  2'-O-methyl modified

<220>  
<221>  modified_base
<222>  (22)..(22)
<223>  2'-O-methyl modified

<400>  1042
uaauccuuga ggaaggugau gg                                                22


<210>  1043
<211>  22
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  Modified antisense strand


<220>
<221>  misc_feature
<222>  (1)..(4)
<223>  linked via phosphorothioate

<220>  
<221>  modified_base
<222>  (1)..(1)
<223>  5'-methoxyphosphonate-4-oxy modified

<220>  
<221>  modified_base
<222>  (2)..(2)
<223>  2'-fluoro modified

<220>  
<221>  modified_base
<222>  (3)..(3)
<223>  2'-fluoro modified

<220>  
<221>  modified_base
<222>  (4)..(4)
<223>  2'-fluoro modified

<220>  
<221>  modified_base
<222>  (5)..(5)
<223>  2'-fluoro modified

<220>  
<221>  modified_base
<222>  (6)..(6)
<223>  2'-O-methyl modified

<220>  
<221>  modified_base
<222>  (7)..(7)
<223>  2'-fluoro modified

<220>  
<221>  modified_base
<222>  (8)..(8)
<223>  2'-O-methyl modified

<220>  
<221>  modified_base
<222>  (9)..(9)
<223>  2'-O-methyl modified

<220>  
<221>  modified_base
<222>  (10)..(10)
<223>  2'-fluoro modified

<220>  
<221>  modified_base
<222>  (11)..(11)
<223>  2'-O-methyl modified

<220>  
<221>  modified_base
<222>  (12)..(12)
<223>  2'-O-methyl modified

<220>  
<221>  modified_base
<222>  (13)..(13)
<223>  2'-O-methyl modified

<220>  
<221>  modified_base
<222>  (14)..(14)
<223>  2'-fluoro modified

<220>  
<221>  modified_base
<222>  (15)..(15)
<223>  2'-O-methyl modified

<220>  
<221>  modified_base
<222>  (16)..(16)
<223>  2'-O-methyl modified

<220>  
<221>  modified_base
<222>  (17)..(17)
<223>  2'-O-methyl modified

<220>  
<221>  modified_base
<222>  (18)..(18)
<223>  2'-O-methyl modified

<220>  
<221>  modified_base
<222>  (19)..(19)
<223>  2'-O-methyl modified

<220>
<221>  misc_feature
<222>  (20)..(22)
<223>  linked via phosphorothioate

<220>  
<221>  modified_base
<222>  (20)..(20)
<223>  2'-O-methyl modified

<220>  
<221>  modified_base
<222>  (21)..(21)
<223>  2'-O-methyl modified

<220>  
<221>  modified_base
<222>  (22)..(22)
<223>  2'-O-methyl modified

<400>  1043
uaaauccuug aggaagguga gg                                                22


<210>  1044
<211>  22
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  Modified antisense strand


<220>
<221>  misc_feature
<222>  (1)..(4)
<223>  linked via phosphorothioate

<220>  
<221>  modified_base
<222>  (1)..(1)
<223>  5'-methoxyphosphonate-4-oxy modified

<220>  
<221>  modified_base
<222>  (2)..(2)
<223>  2'-fluoro modified

<220>  
<221>  modified_base
<222>  (3)..(3)
<223>  2'-fluoro modified

<220>  
<221>  modified_base
<222>  (4)..(4)
<223>  2'-fluoro modified

<220>  
<221>  modified_base
<222>  (5)..(5)
<223>  2'-fluoro modified

<220>  
<221>  modified_base
<222>  (6)..(6)
<223>  2'-O-methyl modified

<220>  
<221>  modified_base
<222>  (7)..(7)
<223>  2'-fluoro modified

<220>  
<221>  modified_base
<222>  (8)..(8)
<223>  2'-O-methyl modified

<220>  
<221>  modified_base
<222>  (9)..(9)
<223>  2'-O-methyl modified

<220>  
<221>  modified_base
<222>  (10)..(10)
<223>  2'-fluoro modified

<220>  
<221>  modified_base
<222>  (11)..(11)
<223>  2'-O-methyl modified

<220>  
<221>  modified_base
<222>  (12)..(12)
<223>  2'-O-methyl modified

<220>  
<221>  modified_base
<222>  (13)..(13)
<223>  2'-O-methyl modified

<220>  
<221>  modified_base
<222>  (14)..(14)
<223>  2'-fluoro modified

<220>  
<221>  modified_base
<222>  (15)..(15)
<223>  2'-O-methyl modified

<220>  
<221>  modified_base
<222>  (16)..(16)
<223>  2'-O-methyl modified

<220>  
<221>  modified_base
<222>  (17)..(17)
<223>  2'-O-methyl modified

<220>  
<221>  modified_base
<222>  (18)..(18)
<223>  2'-O-methyl modified

<220>  
<221>  modified_base
<222>  (19)..(19)
<223>  2'-O-methyl modified

<220>
<221>  misc_feature
<222>  (20)..(22)
<223>  linked via phosphorothioate

<220>  
<221>  modified_base
<222>  (20)..(20)
<223>  2'-O-methyl modified

<220>  
<221>  modified_base
<222>  (21)..(21)
<223>  2'-O-methyl modified

<220>  
<221>  modified_base
<222>  (22)..(22)
<223>  2'-O-methyl modified

<400>  1044
ugaaauccuu gaggaaggug gg                                                22


<210>  1045
<211>  22
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  Modified antisense strand


<220>
<221>  misc_feature
<222>  (1)..(4)
<223>  linked via phosphorothioate

<220>  
<221>  modified_base
<222>  (1)..(1)
<223>  5'-methoxyphosphonate-4-oxy modified

<220>  
<221>  modified_base
<222>  (2)..(2)
<223>  2'-fluoro modified

<220>  
<221>  modified_base
<222>  (3)..(3)
<223>  2'-fluoro modified

<220>  
<221>  modified_base
<222>  (4)..(4)
<223>  2'-fluoro modified

<220>  
<221>  modified_base
<222>  (5)..(5)
<223>  2'-fluoro modified

<220>  
<221>  modified_base
<222>  (6)..(6)
<223>  2'-O-methyl modified

<220>  
<221>  modified_base
<222>  (7)..(7)
<223>  2'-fluoro modified

<220>  
<221>  modified_base
<222>  (8)..(8)
<223>  2'-O-methyl modified

<220>  
<221>  modified_base
<222>  (9)..(9)
<223>  2'-O-methyl modified

<220>  
<221>  modified_base
<222>  (10)..(10)
<223>  2'-fluoro modified

<220>  
<221>  modified_base
<222>  (11)..(11)
<223>  2'-O-methyl modified

<220>  
<221>  modified_base
<222>  (12)..(12)
<223>  2'-O-methyl modified

<220>  
<221>  modified_base
<222>  (13)..(13)
<223>  2'-O-methyl modified

<220>  
<221>  modified_base
<222>  (14)..(14)
<223>  2'-fluoro modified

<220>  
<221>  modified_base
<222>  (15)..(15)
<223>  2'-O-methyl modified

<220>  
<221>  modified_base
<222>  (16)..(16)
<223>  2'-O-methyl modified

<220>  
<221>  modified_base
<222>  (17)..(17)
<223>  2'-O-methyl modified

<220>  
<221>  modified_base
<222>  (18)..(18)
<223>  2'-O-methyl modified

<220>  
<221>  modified_base
<222>  (19)..(19)
<223>  2'-O-methyl modified

<220>
<221>  misc_feature
<222>  (20)..(22)
<223>  linked via phosphorothioate

<220>  
<221>  modified_base
<222>  (20)..(20)
<223>  2'-O-methyl modified

<220>  
<221>  modified_base
<222>  (21)..(21)
<223>  2'-O-methyl modified

<220>  
<221>  modified_base
<222>  (22)..(22)
<223>  2'-O-methyl modified

<400>  1045
uugaaauccu ugaggaaggu gg                                                22


<210>  1046
<211>  22
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  Modified antisense strand


<220>
<221>  misc_feature
<222>  (1)..(4)
<223>  linked via phosphorothioate

<220>  
<221>  modified_base
<222>  (1)..(1)
<223>  5'-methoxyphosphonate-4-oxy modified

<220>  
<221>  modified_base
<222>  (2)..(2)
<223>  2'-fluoro modified

<220>  
<221>  modified_base
<222>  (3)..(3)
<223>  2'-fluoro modified

<220>  
<221>  modified_base
<222>  (4)..(4)
<223>  2'-fluoro modified

<220>  
<221>  modified_base
<222>  (5)..(5)
<223>  2'-fluoro modified

<220>  
<221>  modified_base
<222>  (6)..(6)
<223>  2'-O-methyl modified

<220>  
<221>  modified_base
<222>  (7)..(7)
<223>  2'-fluoro modified

<220>  
<221>  modified_base
<222>  (8)..(8)
<223>  2'-O-methyl modified

<220>  
<221>  modified_base
<222>  (9)..(9)
<223>  2'-O-methyl modified

<220>  
<221>  modified_base
<222>  (10)..(10)
<223>  2'-fluoro modified

<220>  
<221>  modified_base
<222>  (11)..(11)
<223>  2'-O-methyl modified

<220>  
<221>  modified_base
<222>  (12)..(12)
<223>  2'-O-methyl modified

<220>  
<221>  modified_base
<222>  (13)..(13)
<223>  2'-O-methyl modified

<220>  
<221>  modified_base
<222>  (14)..(14)
<223>  2'-fluoro modified

<220>  
<221>  modified_base
<222>  (15)..(15)
<223>  2'-O-methyl modified

<220>  
<221>  modified_base
<222>  (16)..(16)
<223>  2'-O-methyl modified

<220>  
<221>  modified_base
<222>  (17)..(17)
<223>  2'-O-methyl modified

<220>  
<221>  modified_base
<222>  (18)..(18)
<223>  2'-O-methyl modified

<220>  
<221>  modified_base
<222>  (19)..(19)
<223>  2'-O-methyl modified

<220>
<221>  misc_feature
<222>  (20)..(22)
<223>  linked via phosphorothioate

<220>  
<221>  modified_base
<222>  (20)..(20)
<223>  2'-O-methyl modified

<220>  
<221>  modified_base
<222>  (21)..(21)
<223>  2'-O-methyl modified

<220>  
<221>  modified_base
<222>  (22)..(22)
<223>  2'-O-methyl modified

<400>  1046
ucugaaaucc uugaggaagg gg                                                22


<210>  1047
<211>  22
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  Modified antisense strand


<220>
<221>  misc_feature
<222>  (1)..(4)
<223>  linked via phosphorothioate

<220>  
<221>  modified_base
<222>  (1)..(1)
<223>  5'-methoxyphosphonate-4-oxy modified

<220>  
<221>  modified_base
<222>  (2)..(2)
<223>  2'-fluoro modified

<220>  
<221>  modified_base
<222>  (3)..(3)
<223>  2'-fluoro modified

<220>  
<221>  modified_base
<222>  (4)..(4)
<223>  2'-fluoro modified

<220>  
<221>  modified_base
<222>  (5)..(5)
<223>  2'-fluoro modified

<220>  
<221>  modified_base
<222>  (6)..(6)
<223>  2'-O-methyl modified

<220>  
<221>  modified_base
<222>  (7)..(7)
<223>  2'-fluoro modified

<220>  
<221>  modified_base
<222>  (8)..(8)
<223>  2'-O-methyl modified

<220>  
<221>  modified_base
<222>  (9)..(9)
<223>  2'-O-methyl modified

<220>  
<221>  modified_base
<222>  (10)..(10)
<223>  2'-fluoro modified

<220>  
<221>  modified_base
<222>  (11)..(11)
<223>  2'-O-methyl modified

<220>  
<221>  modified_base
<222>  (12)..(12)
<223>  2'-O-methyl modified

<220>  
<221>  modified_base
<222>  (13)..(13)
<223>  2'-O-methyl modified

<220>  
<221>  modified_base
<222>  (14)..(14)
<223>  2'-fluoro modified

<220>  
<221>  modified_base
<222>  (15)..(15)
<223>  2'-O-methyl modified

<220>  
<221>  modified_base
<222>  (16)..(16)
<223>  2'-O-methyl modified

<220>  
<221>  modified_base
<222>  (17)..(17)
<223>  2'-O-methyl modified

<220>  
<221>  modified_base
<222>  (18)..(18)
<223>  2'-O-methyl modified

<220>  
<221>  modified_base
<222>  (19)..(19)
<223>  2'-O-methyl modified

<220>
<221>  misc_feature
<222>  (20)..(22)
<223>  linked via phosphorothioate

<220>  
<221>  modified_base
<222>  (20)..(20)
<223>  2'-O-methyl modified

<220>  
<221>  modified_base
<222>  (21)..(21)
<223>  2'-O-methyl modified

<220>  
<221>  modified_base
<222>  (22)..(22)
<223>  2'-O-methyl modified

<400>  1047
uacugaaauc cuugaggaag gg                                                22


<210>  1048
<211>  22
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  Modified antisense strand


<220>
<221>  misc_feature
<222>  (1)..(4)
<223>  linked via phosphorothioate

<220>  
<221>  modified_base
<222>  (1)..(1)
<223>  5'-methoxyphosphonate-4-oxy modified

<220>  
<221>  modified_base
<222>  (2)..(2)
<223>  2'-fluoro modified

<220>  
<221>  modified_base
<222>  (3)..(3)
<223>  2'-fluoro modified

<220>  
<221>  modified_base
<222>  (4)..(4)
<223>  2'-fluoro modified

<220>  
<221>  modified_base
<222>  (5)..(5)
<223>  2'-fluoro modified

<220>  
<221>  modified_base
<222>  (6)..(6)
<223>  2'-O-methyl modified

<220>  
<221>  modified_base
<222>  (7)..(7)
<223>  2'-fluoro modified

<220>  
<221>  modified_base
<222>  (8)..(8)
<223>  2'-O-methyl modified

<220>  
<221>  modified_base
<222>  (9)..(9)
<223>  2'-O-methyl modified

<220>  
<221>  modified_base
<222>  (10)..(10)
<223>  2'-fluoro modified

<220>  
<221>  modified_base
<222>  (11)..(11)
<223>  2'-O-methyl modified

<220>  
<221>  modified_base
<222>  (12)..(12)
<223>  2'-O-methyl modified

<220>  
<221>  modified_base
<222>  (13)..(13)
<223>  2'-O-methyl modified

<220>  
<221>  modified_base
<222>  (14)..(14)
<223>  2'-fluoro modified

<220>  
<221>  modified_base
<222>  (15)..(15)
<223>  2'-O-methyl modified

<220>  
<221>  modified_base
<222>  (16)..(16)
<223>  2'-O-methyl modified

<220>  
<221>  modified_base
<222>  (17)..(17)
<223>  2'-O-methyl modified

<220>  
<221>  modified_base
<222>  (18)..(18)
<223>  2'-O-methyl modified

<220>  
<221>  modified_base
<222>  (19)..(19)
<223>  2'-O-methyl modified

<220>
<221>  misc_feature
<222>  (20)..(22)
<223>  linked via phosphorothioate

<220>  
<221>  modified_base
<222>  (20)..(20)
<223>  2'-O-methyl modified

<220>  
<221>  modified_base
<222>  (21)..(21)
<223>  2'-O-methyl modified

<220>  
<221>  modified_base
<222>  (22)..(22)
<223>  2'-O-methyl modified

<400>  1048
uaacugaaau ccuugaggaa gg                                                22


<210>  1049
<211>  22
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  Modified antisense strand


<220>
<221>  misc_feature
<222>  (1)..(4)
<223>  linked via phosphorothioate

<220>  
<221>  modified_base
<222>  (1)..(1)
<223>  5'-methoxyphosphonate-4-oxy modified

<220>  
<221>  modified_base
<222>  (2)..(2)
<223>  2'-fluoro modified

<220>  
<221>  modified_base
<222>  (3)..(3)
<223>  2'-fluoro modified

<220>  
<221>  modified_base
<222>  (4)..(4)
<223>  2'-fluoro modified

<220>  
<221>  modified_base
<222>  (5)..(5)
<223>  2'-fluoro modified

<220>  
<221>  modified_base
<222>  (6)..(6)
<223>  2'-O-methyl modified

<220>  
<221>  modified_base
<222>  (7)..(7)
<223>  2'-fluoro modified

<220>  
<221>  modified_base
<222>  (8)..(8)
<223>  2'-O-methyl modified

<220>  
<221>  modified_base
<222>  (9)..(9)
<223>  2'-O-methyl modified

<220>  
<221>  modified_base
<222>  (10)..(10)
<223>  2'-fluoro modified

<220>  
<221>  modified_base
<222>  (11)..(11)
<223>  2'-O-methyl modified

<220>  
<221>  modified_base
<222>  (12)..(12)
<223>  2'-O-methyl modified

<220>  
<221>  modified_base
<222>  (13)..(13)
<223>  2'-O-methyl modified

<220>  
<221>  modified_base
<222>  (14)..(14)
<223>  2'-fluoro modified

<220>  
<221>  modified_base
<222>  (15)..(15)
<223>  2'-O-methyl modified

<220>  
<221>  modified_base
<222>  (16)..(16)
<223>  2'-O-methyl modified

<220>  
<221>  modified_base
<222>  (17)..(17)
<223>  2'-O-methyl modified

<220>  
<221>  modified_base
<222>  (18)..(18)
<223>  2'-O-methyl modified

<220>  
<221>  modified_base
<222>  (19)..(19)
<223>  2'-O-methyl modified

<220>
<221>  misc_feature
<222>  (20)..(22)
<223>  linked via phosphorothioate

<220>  
<221>  modified_base
<222>  (20)..(20)
<223>  2'-O-methyl modified

<220>  
<221>  modified_base
<222>  (21)..(21)
<223>  2'-O-methyl modified

<220>  
<221>  modified_base
<222>  (22)..(22)
<223>  2'-O-methyl modified

<400>  1049
uuaacugaaa uccuugagga gg                                                22


<210>  1050
<211>  22
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  Modified antisense strand


<220>
<221>  misc_feature
<222>  (1)..(4)
<223>  linked via phosphorothioate

<220>  
<221>  modified_base
<222>  (1)..(1)
<223>  5'-methoxyphosphonate-4-oxy modified

<220>  
<221>  modified_base
<222>  (2)..(2)
<223>  2'-fluoro modified

<220>  
<221>  modified_base
<222>  (3)..(3)
<223>  2'-fluoro modified

<220>  
<221>  modified_base
<222>  (4)..(4)
<223>  2'-fluoro modified

<220>  
<221>  modified_base
<222>  (5)..(5)
<223>  2'-fluoro modified

<220>  
<221>  modified_base
<222>  (6)..(6)
<223>  2'-O-methyl modified

<220>  
<221>  modified_base
<222>  (7)..(7)
<223>  2'-fluoro modified

<220>  
<221>  modified_base
<222>  (8)..(8)
<223>  2'-O-methyl modified

<220>  
<221>  modified_base
<222>  (9)..(9)
<223>  2'-O-methyl modified

<220>  
<221>  modified_base
<222>  (10)..(10)
<223>  2'-fluoro modified

<220>  
<221>  modified_base
<222>  (11)..(11)
<223>  2'-O-methyl modified

<220>  
<221>  modified_base
<222>  (12)..(12)
<223>  2'-O-methyl modified

<220>  
<221>  modified_base
<222>  (13)..(13)
<223>  2'-O-methyl modified

<220>  
<221>  modified_base
<222>  (14)..(14)
<223>  2'-fluoro modified

<220>  
<221>  modified_base
<222>  (15)..(15)
<223>  2'-O-methyl modified

<220>  
<221>  modified_base
<222>  (16)..(16)
<223>  2'-O-methyl modified

<220>  
<221>  modified_base
<222>  (17)..(17)
<223>  2'-O-methyl modified

<220>  
<221>  modified_base
<222>  (18)..(18)
<223>  2'-O-methyl modified

<220>  
<221>  modified_base
<222>  (19)..(19)
<223>  2'-O-methyl modified

<220>
<221>  misc_feature
<222>  (20)..(22)
<223>  linked via phosphorothioate

<220>  
<221>  modified_base
<222>  (20)..(20)
<223>  2'-O-methyl modified

<220>  
<221>  modified_base
<222>  (21)..(21)
<223>  2'-O-methyl modified

<220>  
<221>  modified_base
<222>  (22)..(22)
<223>  2'-O-methyl modified

<400>  1050
uauaacugaa auccuugagg gg                                                22


<210>  1051
<211>  22
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  Modified antisense strand


<220>
<221>  misc_feature
<222>  (1)..(4)
<223>  linked via phosphorothioate

<220>  
<221>  modified_base
<222>  (1)..(1)
<223>  5'-methoxyphosphonate-4-oxy modified

<220>  
<221>  modified_base
<222>  (2)..(2)
<223>  2'-fluoro modified

<220>  
<221>  modified_base
<222>  (3)..(3)
<223>  2'-fluoro modified

<220>  
<221>  modified_base
<222>  (4)..(4)
<223>  2'-fluoro modified

<220>  
<221>  modified_base
<222>  (5)..(5)
<223>  2'-fluoro modified

<220>  
<221>  modified_base
<222>  (6)..(6)
<223>  2'-O-methyl modified

<220>  
<221>  modified_base
<222>  (7)..(7)
<223>  2'-fluoro modified

<220>  
<221>  modified_base
<222>  (8)..(8)
<223>  2'-O-methyl modified

<220>  
<221>  modified_base
<222>  (9)..(9)
<223>  2'-O-methyl modified

<220>  
<221>  modified_base
<222>  (10)..(10)
<223>  2'-fluoro modified

<220>  
<221>  modified_base
<222>  (11)..(11)
<223>  2'-O-methyl modified

<220>  
<221>  modified_base
<222>  (12)..(12)
<223>  2'-O-methyl modified

<220>  
<221>  modified_base
<222>  (13)..(13)
<223>  2'-O-methyl modified

<220>  
<221>  modified_base
<222>  (14)..(14)
<223>  2'-fluoro modified

<220>  
<221>  modified_base
<222>  (15)..(15)
<223>  2'-O-methyl modified

<220>  
<221>  modified_base
<222>  (16)..(16)
<223>  2'-O-methyl modified

<220>  
<221>  modified_base
<222>  (17)..(17)
<223>  2'-O-methyl modified

<220>  
<221>  modified_base
<222>  (18)..(18)
<223>  2'-O-methyl modified

<220>  
<221>  modified_base
<222>  (19)..(19)
<223>  2'-O-methyl modified

<220>
<221>  misc_feature
<222>  (20)..(22)
<223>  linked via phosphorothioate

<220>  
<221>  modified_base
<222>  (20)..(20)
<223>  2'-O-methyl modified

<220>  
<221>  modified_base
<222>  (21)..(21)
<223>  2'-O-methyl modified

<220>  
<221>  modified_base
<222>  (22)..(22)
<223>  2'-O-methyl modified

<400>  1051
uuauaacuga aauccuugag gg                                                22


<210>  1052
<211>  22
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  Modified antisense strand


<220>
<221>  misc_feature
<222>  (1)..(4)
<223>  linked via phosphorothioate

<220>  
<221>  modified_base
<222>  (1)..(1)
<223>  5'-methoxyphosphonate-4-oxy modified

<220>  
<221>  modified_base
<222>  (2)..(2)
<223>  2'-fluoro modified

<220>  
<221>  modified_base
<222>  (3)..(3)
<223>  2'-fluoro modified

<220>  
<221>  modified_base
<222>  (4)..(4)
<223>  2'-fluoro modified

<220>  
<221>  modified_base
<222>  (5)..(5)
<223>  2'-fluoro modified

<220>  
<221>  modified_base
<222>  (6)..(6)
<223>  2'-O-methyl modified

<220>  
<221>  modified_base
<222>  (7)..(7)
<223>  2'-fluoro modified

<220>  
<221>  modified_base
<222>  (8)..(8)
<223>  2'-O-methyl modified

<220>  
<221>  modified_base
<222>  (9)..(9)
<223>  2'-O-methyl modified

<220>  
<221>  modified_base
<222>  (10)..(10)
<223>  2'-fluoro modified

<220>  
<221>  modified_base
<222>  (11)..(11)
<223>  2'-O-methyl modified

<220>  
<221>  modified_base
<222>  (12)..(12)
<223>  2'-O-methyl modified

<220>  
<221>  modified_base
<222>  (13)..(13)
<223>  2'-O-methyl modified

<220>  
<221>  modified_base
<222>  (14)..(14)
<223>  2'-fluoro modified

<220>  
<221>  modified_base
<222>  (15)..(15)
<223>  2'-O-methyl modified

<220>  
<221>  modified_base
<222>  (16)..(16)
<223>  2'-O-methyl modified

<220>  
<221>  modified_base
<222>  (17)..(17)
<223>  2'-O-methyl modified

<220>  
<221>  modified_base
<222>  (18)..(18)
<223>  2'-O-methyl modified

<220>  
<221>  modified_base
<222>  (19)..(19)
<223>  2'-O-methyl modified

<220>
<221>  misc_feature
<222>  (20)..(22)
<223>  linked via phosphorothioate

<220>  
<221>  modified_base
<222>  (20)..(20)
<223>  2'-O-methyl modified

<220>  
<221>  modified_base
<222>  (21)..(21)
<223>  2'-O-methyl modified

<220>  
<221>  modified_base
<222>  (22)..(22)
<223>  2'-O-methyl modified

<400>  1052
uuuauaacug aaauccuuga gg                                                22


<210>  1053
<211>  22
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  Modified antisense strand


<220>
<221>  misc_feature
<222>  (1)..(4)
<223>  linked via phosphorothioate

<220>  
<221>  modified_base
<222>  (1)..(1)
<223>  5'-methoxyphosphonate-4-oxy modified

<220>  
<221>  modified_base
<222>  (2)..(2)
<223>  2'-fluoro modified

<220>  
<221>  modified_base
<222>  (3)..(3)
<223>  2'-fluoro modified

<220>  
<221>  modified_base
<222>  (4)..(4)
<223>  2'-fluoro modified

<220>  
<221>  modified_base
<222>  (5)..(5)
<223>  2'-fluoro modified

<220>  
<221>  modified_base
<222>  (6)..(6)
<223>  2'-O-methyl modified

<220>  
<221>  modified_base
<222>  (7)..(7)
<223>  2'-fluoro modified

<220>  
<221>  modified_base
<222>  (8)..(8)
<223>  2'-O-methyl modified

<220>  
<221>  modified_base
<222>  (9)..(9)
<223>  2'-O-methyl modified

<220>  
<221>  modified_base
<222>  (10)..(10)
<223>  2'-fluoro modified

<220>  
<221>  modified_base
<222>  (11)..(11)
<223>  2'-O-methyl modified

<220>  
<221>  modified_base
<222>  (12)..(12)
<223>  2'-O-methyl modified

<220>  
<221>  modified_base
<222>  (13)..(13)
<223>  2'-O-methyl modified

<220>  
<221>  modified_base
<222>  (14)..(14)
<223>  2'-fluoro modified

<220>  
<221>  modified_base
<222>  (15)..(15)
<223>  2'-O-methyl modified

<220>  
<221>  modified_base
<222>  (16)..(16)
<223>  2'-O-methyl modified

<220>  
<221>  modified_base
<222>  (17)..(17)
<223>  2'-O-methyl modified

<220>  
<221>  modified_base
<222>  (18)..(18)
<223>  2'-O-methyl modified

<220>  
<221>  modified_base
<222>  (19)..(19)
<223>  2'-O-methyl modified

<220>
<221>  misc_feature
<222>  (20)..(22)
<223>  linked via phosphorothioate

<220>  
<221>  modified_base
<222>  (20)..(20)
<223>  2'-O-methyl modified

<220>  
<221>  modified_base
<222>  (21)..(21)
<223>  2'-O-methyl modified

<220>  
<221>  modified_base
<222>  (22)..(22)
<223>  2'-O-methyl modified

<400>  1053
uguuauaacu gaaauccuug gg                                                22


<210>  1054
<211>  22
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  Modified antisense strand


<220>
<221>  misc_feature
<222>  (1)..(4)
<223>  linked via phosphorothioate

<220>  
<221>  modified_base
<222>  (1)..(1)
<223>  5'-methoxyphosphonate-4-oxy modified

<220>  
<221>  modified_base
<222>  (2)..(2)
<223>  2'-fluoro modified

<220>  
<221>  modified_base
<222>  (3)..(3)
<223>  2'-fluoro modified

<220>  
<221>  modified_base
<222>  (4)..(4)
<223>  2'-fluoro modified

<220>  
<221>  modified_base
<222>  (5)..(5)
<223>  2'-fluoro modified

<220>  
<221>  modified_base
<222>  (6)..(6)
<223>  2'-O-methyl modified

<220>  
<221>  modified_base
<222>  (7)..(7)
<223>  2'-fluoro modified

<220>  
<221>  modified_base
<222>  (8)..(8)
<223>  2'-O-methyl modified

<220>  
<221>  modified_base
<222>  (9)..(9)
<223>  2'-O-methyl modified

<220>  
<221>  modified_base
<222>  (10)..(10)
<223>  2'-fluoro modified

<220>  
<221>  modified_base
<222>  (11)..(11)
<223>  2'-O-methyl modified

<220>  
<221>  modified_base
<222>  (12)..(12)
<223>  2'-O-methyl modified

<220>  
<221>  modified_base
<222>  (13)..(13)
<223>  2'-O-methyl modified

<220>  
<221>  modified_base
<222>  (14)..(14)
<223>  2'-fluoro modified

<220>  
<221>  modified_base
<222>  (15)..(15)
<223>  2'-O-methyl modified

<220>  
<221>  modified_base
<222>  (16)..(16)
<223>  2'-O-methyl modified

<220>  
<221>  modified_base
<222>  (17)..(17)
<223>  2'-O-methyl modified

<220>  
<221>  modified_base
<222>  (18)..(18)
<223>  2'-O-methyl modified

<220>  
<221>  modified_base
<222>  (19)..(19)
<223>  2'-O-methyl modified

<220>
<221>  misc_feature
<222>  (20)..(22)
<223>  linked via phosphorothioate

<220>  
<221>  modified_base
<222>  (20)..(20)
<223>  2'-O-methyl modified

<220>  
<221>  modified_base
<222>  (21)..(21)
<223>  2'-O-methyl modified

<220>  
<221>  modified_base
<222>  (22)..(22)
<223>  2'-O-methyl modified

<400>  1054
ugguuauaac ugaaauccuu gg                                                22


<210>  1055
<211>  22
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  Modified antisense strand


<220>
<221>  misc_feature
<222>  (1)..(4)
<223>  linked via phosphorothioate

<220>  
<221>  modified_base
<222>  (1)..(1)
<223>  5'-methoxyphosphonate-4-oxy modified

<220>  
<221>  modified_base
<222>  (2)..(2)
<223>  2'-fluoro modified

<220>  
<221>  modified_base
<222>  (3)..(3)
<223>  2'-fluoro modified

<220>  
<221>  modified_base
<222>  (4)..(4)
<223>  2'-fluoro modified

<220>  
<221>  modified_base
<222>  (5)..(5)
<223>  2'-fluoro modified

<220>  
<221>  modified_base
<222>  (6)..(6)
<223>  2'-O-methyl modified

<220>  
<221>  modified_base
<222>  (7)..(7)
<223>  2'-fluoro modified

<220>  
<221>  modified_base
<222>  (8)..(8)
<223>  2'-O-methyl modified

<220>  
<221>  modified_base
<222>  (9)..(9)
<223>  2'-O-methyl modified

<220>  
<221>  modified_base
<222>  (10)..(10)
<223>  2'-fluoro modified

<220>  
<221>  modified_base
<222>  (11)..(11)
<223>  2'-O-methyl modified

<220>  
<221>  modified_base
<222>  (12)..(12)
<223>  2'-O-methyl modified

<220>  
<221>  modified_base
<222>  (13)..(13)
<223>  2'-O-methyl modified

<220>  
<221>  modified_base
<222>  (14)..(14)
<223>  2'-fluoro modified

<220>  
<221>  modified_base
<222>  (15)..(15)
<223>  2'-O-methyl modified

<220>  
<221>  modified_base
<222>  (16)..(16)
<223>  2'-O-methyl modified

<220>  
<221>  modified_base
<222>  (17)..(17)
<223>  2'-O-methyl modified

<220>  
<221>  modified_base
<222>  (18)..(18)
<223>  2'-O-methyl modified

<220>  
<221>  modified_base
<222>  (19)..(19)
<223>  2'-O-methyl modified

<220>
<221>  misc_feature
<222>  (20)..(22)
<223>  linked via phosphorothioate

<220>  
<221>  modified_base
<222>  (20)..(20)
<223>  2'-O-methyl modified

<220>  
<221>  modified_base
<222>  (21)..(21)
<223>  2'-O-methyl modified

<220>  
<221>  modified_base
<222>  (22)..(22)
<223>  2'-O-methyl modified

<400>  1055
ucgguuauaa cugaaauccu gg                                                22


<210>  1056
<211>  22
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  Modified antisense strand


<220>
<221>  misc_feature
<222>  (1)..(4)
<223>  linked via phosphorothioate

<220>  
<221>  modified_base
<222>  (1)..(1)
<223>  5'-methoxyphosphonate-4-oxy modified

<220>  
<221>  modified_base
<222>  (2)..(2)
<223>  2'-fluoro modified

<220>  
<221>  modified_base
<222>  (3)..(3)
<223>  2'-fluoro modified

<220>  
<221>  modified_base
<222>  (4)..(4)
<223>  2'-fluoro modified

<220>  
<221>  modified_base
<222>  (5)..(5)
<223>  2'-fluoro modified

<220>  
<221>  modified_base
<222>  (6)..(6)
<223>  2'-O-methyl modified

<220>  
<221>  modified_base
<222>  (7)..(7)
<223>  2'-fluoro modified

<220>  
<221>  modified_base
<222>  (8)..(8)
<223>  2'-O-methyl modified

<220>  
<221>  modified_base
<222>  (9)..(9)
<223>  2'-O-methyl modified

<220>  
<221>  modified_base
<222>  (10)..(10)
<223>  2'-fluoro modified

<220>  
<221>  modified_base
<222>  (11)..(11)
<223>  2'-O-methyl modified

<220>  
<221>  modified_base
<222>  (12)..(12)
<223>  2'-O-methyl modified

<220>  
<221>  modified_base
<222>  (13)..(13)
<223>  2'-O-methyl modified

<220>  
<221>  modified_base
<222>  (14)..(14)
<223>  2'-fluoro modified

<220>  
<221>  modified_base
<222>  (15)..(15)
<223>  2'-O-methyl modified

<220>  
<221>  modified_base
<222>  (16)..(16)
<223>  2'-O-methyl modified

<220>  
<221>  modified_base
<222>  (17)..(17)
<223>  2'-O-methyl modified

<220>  
<221>  modified_base
<222>  (18)..(18)
<223>  2'-O-methyl modified

<220>  
<221>  modified_base
<222>  (19)..(19)
<223>  2'-O-methyl modified

<220>
<221>  misc_feature
<222>  (20)..(22)
<223>  linked via phosphorothioate

<220>  
<221>  modified_base
<222>  (20)..(20)
<223>  2'-O-methyl modified

<220>  
<221>  modified_base
<222>  (21)..(21)
<223>  2'-O-methyl modified

<220>  
<221>  modified_base
<222>  (22)..(22)
<223>  2'-O-methyl modified

<400>  1056
uccgguuaua acugaaaucc gg                                                22


<210>  1057
<211>  22
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  Modified antisense strand


<220>
<221>  misc_feature
<222>  (1)..(4)
<223>  linked via phosphorothioate

<220>  
<221>  modified_base
<222>  (1)..(1)
<223>  5'-methoxyphosphonate-4-oxy modified

<220>  
<221>  modified_base
<222>  (2)..(2)
<223>  2'-fluoro modified

<220>  
<221>  modified_base
<222>  (3)..(3)
<223>  2'-fluoro modified

<220>  
<221>  modified_base
<222>  (4)..(4)
<223>  2'-fluoro modified

<220>  
<221>  modified_base
<222>  (5)..(5)
<223>  2'-fluoro modified

<220>  
<221>  modified_base
<222>  (6)..(6)
<223>  2'-O-methyl modified

<220>  
<221>  modified_base
<222>  (7)..(7)
<223>  2'-fluoro modified

<220>  
<221>  modified_base
<222>  (8)..(8)
<223>  2'-O-methyl modified

<220>  
<221>  modified_base
<222>  (9)..(9)
<223>  2'-O-methyl modified

<220>  
<221>  modified_base
<222>  (10)..(10)
<223>  2'-fluoro modified

<220>  
<221>  modified_base
<222>  (11)..(11)
<223>  2'-O-methyl modified

<220>  
<221>  modified_base
<222>  (12)..(12)
<223>  2'-O-methyl modified

<220>  
<221>  modified_base
<222>  (13)..(13)
<223>  2'-O-methyl modified

<220>  
<221>  modified_base
<222>  (14)..(14)
<223>  2'-fluoro modified

<220>  
<221>  modified_base
<222>  (15)..(15)
<223>  2'-O-methyl modified

<220>  
<221>  modified_base
<222>  (16)..(16)
<223>  2'-O-methyl modified

<220>  
<221>  modified_base
<222>  (17)..(17)
<223>  2'-O-methyl modified

<220>  
<221>  modified_base
<222>  (18)..(18)
<223>  2'-O-methyl modified

<220>  
<221>  modified_base
<222>  (19)..(19)
<223>  2'-O-methyl modified

<220>
<221>  misc_feature
<222>  (20)..(22)
<223>  linked via phosphorothioate

<220>  
<221>  modified_base
<222>  (20)..(20)
<223>  2'-O-methyl modified

<220>  
<221>  modified_base
<222>  (21)..(21)
<223>  2'-O-methyl modified

<220>  
<221>  modified_base
<222>  (22)..(22)
<223>  2'-O-methyl modified

<400>  1057
ugucuucccg guuauaacug gg                                                22


<210>  1058
<211>  22
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  Modified antisense strand


<220>
<221>  misc_feature
<222>  (1)..(4)
<223>  linked via phosphorothioate

<220>  
<221>  modified_base
<222>  (1)..(1)
<223>  5'-methoxyphosphonate-4-oxy modified

<220>  
<221>  modified_base
<222>  (2)..(2)
<223>  2'-fluoro modified

<220>  
<221>  modified_base
<222>  (3)..(3)
<223>  2'-fluoro modified

<220>  
<221>  modified_base
<222>  (4)..(4)
<223>  2'-fluoro modified

<220>  
<221>  modified_base
<222>  (5)..(5)
<223>  2'-fluoro modified

<220>  
<221>  modified_base
<222>  (6)..(6)
<223>  2'-O-methyl modified

<220>  
<221>  modified_base
<222>  (7)..(7)
<223>  2'-fluoro modified

<220>  
<221>  modified_base
<222>  (8)..(8)
<223>  2'-O-methyl modified

<220>  
<221>  modified_base
<222>  (9)..(9)
<223>  2'-O-methyl modified

<220>  
<221>  modified_base
<222>  (10)..(10)
<223>  2'-fluoro modified

<220>  
<221>  modified_base
<222>  (11)..(11)
<223>  2'-O-methyl modified

<220>  
<221>  modified_base
<222>  (12)..(12)
<223>  2'-O-methyl modified

<220>  
<221>  modified_base
<222>  (13)..(13)
<223>  2'-O-methyl modified

<220>  
<221>  modified_base
<222>  (14)..(14)
<223>  2'-fluoro modified

<220>  
<221>  modified_base
<222>  (15)..(15)
<223>  2'-O-methyl modified

<220>  
<221>  modified_base
<222>  (16)..(16)
<223>  2'-O-methyl modified

<220>  
<221>  modified_base
<222>  (17)..(17)
<223>  2'-O-methyl modified

<220>  
<221>  modified_base
<222>  (18)..(18)
<223>  2'-O-methyl modified

<220>  
<221>  modified_base
<222>  (19)..(19)
<223>  2'-O-methyl modified

<220>
<221>  misc_feature
<222>  (20)..(22)
<223>  linked via phosphorothioate

<220>  
<221>  modified_base
<222>  (20)..(20)
<223>  2'-O-methyl modified

<220>  
<221>  modified_base
<222>  (21)..(21)
<223>  2'-O-methyl modified

<220>  
<221>  modified_base
<222>  (22)..(22)
<223>  2'-O-methyl modified

<400>  1058
uagucuuccc gguuauaacu gg                                                22


<210>  1059
<211>  22
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  Modified antisense strand


<220>
<221>  misc_feature
<222>  (1)..(4)
<223>  linked via phosphorothioate

<220>  
<221>  modified_base
<222>  (1)..(1)
<223>  5'-methoxyphosphonate-4-oxy modified

<220>  
<221>  modified_base
<222>  (2)..(2)
<223>  2'-fluoro modified

<220>  
<221>  modified_base
<222>  (3)..(3)
<223>  2'-fluoro modified

<220>  
<221>  modified_base
<222>  (4)..(4)
<223>  2'-fluoro modified

<220>  
<221>  modified_base
<222>  (5)..(5)
<223>  2'-fluoro modified

<220>  
<221>  modified_base
<222>  (6)..(6)
<223>  2'-O-methyl modified

<220>  
<221>  modified_base
<222>  (7)..(7)
<223>  2'-fluoro modified

<220>  
<221>  modified_base
<222>  (8)..(8)
<223>  2'-O-methyl modified

<220>  
<221>  modified_base
<222>  (9)..(9)
<223>  2'-O-methyl modified

<220>  
<221>  modified_base
<222>  (10)..(10)
<223>  2'-fluoro modified

<220>  
<221>  modified_base
<222>  (11)..(11)
<223>  2'-O-methyl modified

<220>  
<221>  modified_base
<222>  (12)..(12)
<223>  2'-O-methyl modified

<220>  
<221>  modified_base
<222>  (13)..(13)
<223>  2'-O-methyl modified

<220>  
<221>  modified_base
<222>  (14)..(14)
<223>  2'-fluoro modified

<220>  
<221>  modified_base
<222>  (15)..(15)
<223>  2'-O-methyl modified

<220>  
<221>  modified_base
<222>  (16)..(16)
<223>  2'-O-methyl modified

<220>  
<221>  modified_base
<222>  (17)..(17)
<223>  2'-O-methyl modified

<220>  
<221>  modified_base
<222>  (18)..(18)
<223>  2'-O-methyl modified

<220>  
<221>  modified_base
<222>  (19)..(19)
<223>  2'-O-methyl modified

<220>
<221>  misc_feature
<222>  (20)..(22)
<223>  linked via phosphorothioate

<220>  
<221>  modified_base
<222>  (20)..(20)
<223>  2'-O-methyl modified

<220>  
<221>  modified_base
<222>  (21)..(21)
<223>  2'-O-methyl modified

<220>  
<221>  modified_base
<222>  (22)..(22)
<223>  2'-O-methyl modified

<400>  1059
ucaaagucuu cccgguuaua gg                                                22


<210>  1060
<211>  22
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  Modified antisense strand


<220>
<221>  misc_feature
<222>  (1)..(4)
<223>  linked via phosphorothioate

<220>  
<221>  modified_base
<222>  (1)..(1)
<223>  5'-methoxyphosphonate-4-oxy modified

<220>  
<221>  modified_base
<222>  (2)..(2)
<223>  2'-fluoro modified

<220>  
<221>  modified_base
<222>  (3)..(3)
<223>  2'-fluoro modified

<220>  
<221>  modified_base
<222>  (4)..(4)
<223>  2'-fluoro modified

<220>  
<221>  modified_base
<222>  (5)..(5)
<223>  2'-fluoro modified

<220>  
<221>  modified_base
<222>  (6)..(6)
<223>  2'-O-methyl modified

<220>  
<221>  modified_base
<222>  (7)..(7)
<223>  2'-fluoro modified

<220>  
<221>  modified_base
<222>  (8)..(8)
<223>  2'-O-methyl modified

<220>  
<221>  modified_base
<222>  (9)..(9)
<223>  2'-O-methyl modified

<220>  
<221>  modified_base
<222>  (10)..(10)
<223>  2'-fluoro modified

<220>  
<221>  modified_base
<222>  (11)..(11)
<223>  2'-O-methyl modified

<220>  
<221>  modified_base
<222>  (12)..(12)
<223>  2'-O-methyl modified

<220>  
<221>  modified_base
<222>  (13)..(13)
<223>  2'-O-methyl modified

<220>  
<221>  modified_base
<222>  (14)..(14)
<223>  2'-fluoro modified

<220>  
<221>  modified_base
<222>  (15)..(15)
<223>  2'-O-methyl modified

<220>  
<221>  modified_base
<222>  (16)..(16)
<223>  2'-O-methyl modified

<220>  
<221>  modified_base
<222>  (17)..(17)
<223>  2'-O-methyl modified

<220>  
<221>  modified_base
<222>  (18)..(18)
<223>  2'-O-methyl modified

<220>  
<221>  modified_base
<222>  (19)..(19)
<223>  2'-O-methyl modified

<220>
<221>  misc_feature
<222>  (20)..(22)
<223>  linked via phosphorothioate

<220>  
<221>  modified_base
<222>  (20)..(20)
<223>  2'-O-methyl modified

<220>  
<221>  modified_base
<222>  (21)..(21)
<223>  2'-O-methyl modified

<220>  
<221>  modified_base
<222>  (22)..(22)
<223>  2'-O-methyl modified

<400>  1060
ucacuugcag cccugcuuug gg                                                22


<210>  1061
<211>  22
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  Modified antisense strand


<220>
<221>  misc_feature
<222>  (1)..(4)
<223>  linked via phosphorothioate

<220>  
<221>  modified_base
<222>  (1)..(1)
<223>  5'-methoxyphosphonate-4-oxy modified

<220>  
<221>  modified_base
<222>  (2)..(2)
<223>  2'-fluoro modified

<220>  
<221>  modified_base
<222>  (3)..(3)
<223>  2'-fluoro modified

<220>  
<221>  modified_base
<222>  (4)..(4)
<223>  2'-fluoro modified

<220>  
<221>  modified_base
<222>  (5)..(5)
<223>  2'-fluoro modified

<220>  
<221>  modified_base
<222>  (6)..(6)
<223>  2'-O-methyl modified

<220>  
<221>  modified_base
<222>  (7)..(7)
<223>  2'-fluoro modified

<220>  
<221>  modified_base
<222>  (8)..(8)
<223>  2'-O-methyl modified

<220>  
<221>  modified_base
<222>  (9)..(9)
<223>  2'-O-methyl modified

<220>  
<221>  modified_base
<222>  (10)..(10)
<223>  2'-fluoro modified

<220>  
<221>  modified_base
<222>  (11)..(11)
<223>  2'-O-methyl modified

<220>  
<221>  modified_base
<222>  (12)..(12)
<223>  2'-O-methyl modified

<220>  
<221>  modified_base
<222>  (13)..(13)
<223>  2'-O-methyl modified

<220>  
<221>  modified_base
<222>  (14)..(14)
<223>  2'-fluoro modified

<220>  
<221>  modified_base
<222>  (15)..(15)
<223>  2'-O-methyl modified

<220>  
<221>  modified_base
<222>  (16)..(16)
<223>  2'-O-methyl modified

<220>  
<221>  modified_base
<222>  (17)..(17)
<223>  2'-O-methyl modified

<220>  
<221>  modified_base
<222>  (18)..(18)
<223>  2'-O-methyl modified

<220>  
<221>  modified_base
<222>  (19)..(19)
<223>  2'-O-methyl modified

<220>
<221>  misc_feature
<222>  (20)..(22)
<223>  linked via phosphorothioate

<220>  
<221>  modified_base
<222>  (20)..(20)
<223>  2'-O-methyl modified

<220>  
<221>  modified_base
<222>  (21)..(21)
<223>  2'-O-methyl modified

<220>  
<221>  modified_base
<222>  (22)..(22)
<223>  2'-O-methyl modified

<400>  1061
uaauuccacu ugcagcccug gg                                                22


<210>  1062
<211>  22
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  Modified antisense strand


<220>
<221>  misc_feature
<222>  (1)..(4)
<223>  linked via phosphorothioate

<220>  
<221>  modified_base
<222>  (1)..(1)
<223>  5'-methoxyphosphonate-4-oxy modified

<220>  
<221>  modified_base
<222>  (2)..(2)
<223>  2'-fluoro modified

<220>  
<221>  modified_base
<222>  (3)..(3)
<223>  2'-fluoro modified

<220>  
<221>  modified_base
<222>  (4)..(4)
<223>  2'-fluoro modified

<220>  
<221>  modified_base
<222>  (5)..(5)
<223>  2'-fluoro modified

<220>  
<221>  modified_base
<222>  (6)..(6)
<223>  2'-O-methyl modified

<220>  
<221>  modified_base
<222>  (7)..(7)
<223>  2'-fluoro modified

<220>  
<221>  modified_base
<222>  (8)..(8)
<223>  2'-O-methyl modified

<220>  
<221>  modified_base
<222>  (9)..(9)
<223>  2'-O-methyl modified

<220>  
<221>  modified_base
<222>  (10)..(10)
<223>  2'-fluoro modified

<220>  
<221>  modified_base
<222>  (11)..(11)
<223>  2'-O-methyl modified

<220>  
<221>  modified_base
<222>  (12)..(12)
<223>  2'-O-methyl modified

<220>  
<221>  modified_base
<222>  (13)..(13)
<223>  2'-O-methyl modified

<220>  
<221>  modified_base
<222>  (14)..(14)
<223>  2'-fluoro modified

<220>  
<221>  modified_base
<222>  (15)..(15)
<223>  2'-O-methyl modified

<220>  
<221>  modified_base
<222>  (16)..(16)
<223>  2'-O-methyl modified

<220>  
<221>  modified_base
<222>  (17)..(17)
<223>  2'-O-methyl modified

<220>  
<221>  modified_base
<222>  (18)..(18)
<223>  2'-O-methyl modified

<220>  
<221>  modified_base
<222>  (19)..(19)
<223>  2'-O-methyl modified

<220>
<221>  misc_feature
<222>  (20)..(22)
<223>  linked via phosphorothioate

<220>  
<221>  modified_base
<222>  (20)..(20)
<223>  2'-O-methyl modified

<220>  
<221>  modified_base
<222>  (21)..(21)
<223>  2'-O-methyl modified

<220>  
<221>  modified_base
<222>  (22)..(22)
<223>  2'-O-methyl modified

<400>  1062
uaugaauucc acuugcagcc gg                                                22


<210>  1063
<211>  22
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  Modified antisense strand


<220>
<221>  misc_feature
<222>  (1)..(4)
<223>  linked via phosphorothioate

<220>  
<221>  modified_base
<222>  (1)..(1)
<223>  5'-methoxyphosphonate-4-oxy modified

<220>  
<221>  modified_base
<222>  (2)..(2)
<223>  2'-fluoro modified

<220>  
<221>  modified_base
<222>  (3)..(3)
<223>  2'-fluoro modified

<220>  
<221>  modified_base
<222>  (4)..(4)
<223>  2'-fluoro modified

<220>  
<221>  modified_base
<222>  (5)..(5)
<223>  2'-fluoro modified

<220>  
<221>  modified_base
<222>  (6)..(6)
<223>  2'-O-methyl modified

<220>  
<221>  modified_base
<222>  (7)..(7)
<223>  2'-fluoro modified

<220>  
<221>  modified_base
<222>  (8)..(8)
<223>  2'-O-methyl modified

<220>  
<221>  modified_base
<222>  (9)..(9)
<223>  2'-O-methyl modified

<220>  
<221>  modified_base
<222>  (10)..(10)
<223>  2'-fluoro modified

<220>  
<221>  modified_base
<222>  (11)..(11)
<223>  2'-O-methyl modified

<220>  
<221>  modified_base
<222>  (12)..(12)
<223>  2'-O-methyl modified

<220>  
<221>  modified_base
<222>  (13)..(13)
<223>  2'-O-methyl modified

<220>  
<221>  modified_base
<222>  (14)..(14)
<223>  2'-fluoro modified

<220>  
<221>  modified_base
<222>  (15)..(15)
<223>  2'-O-methyl modified

<220>  
<221>  modified_base
<222>  (16)..(16)
<223>  2'-O-methyl modified

<220>  
<221>  modified_base
<222>  (17)..(17)
<223>  2'-O-methyl modified

<220>  
<221>  modified_base
<222>  (18)..(18)
<223>  2'-O-methyl modified

<220>  
<221>  modified_base
<222>  (19)..(19)
<223>  2'-O-methyl modified

<220>
<221>  misc_feature
<222>  (20)..(22)
<223>  linked via phosphorothioate

<220>  
<221>  modified_base
<222>  (20)..(20)
<223>  2'-O-methyl modified

<220>  
<221>  modified_base
<222>  (21)..(21)
<223>  2'-O-methyl modified

<220>  
<221>  modified_base
<222>  (22)..(22)
<223>  2'-O-methyl modified

<400>  1063
uugaugaauu ccacuugcag gg                                                22


<210>  1064
<211>  22
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  Modified antisense strand


<220>
<221>  misc_feature
<222>  (1)..(4)
<223>  linked via phosphorothioate

<220>  
<221>  modified_base
<222>  (1)..(1)
<223>  5'-methoxyphosphonate-4-oxy modified

<220>  
<221>  modified_base
<222>  (2)..(2)
<223>  2'-fluoro modified

<220>  
<221>  modified_base
<222>  (3)..(3)
<223>  2'-fluoro modified

<220>  
<221>  modified_base
<222>  (4)..(4)
<223>  2'-fluoro modified

<220>  
<221>  modified_base
<222>  (5)..(5)
<223>  2'-fluoro modified

<220>  
<221>  modified_base
<222>  (6)..(6)
<223>  2'-O-methyl modified

<220>  
<221>  modified_base
<222>  (7)..(7)
<223>  2'-fluoro modified

<220>  
<221>  modified_base
<222>  (8)..(8)
<223>  2'-O-methyl modified

<220>  
<221>  modified_base
<222>  (9)..(9)
<223>  2'-O-methyl modified

<220>  
<221>  modified_base
<222>  (10)..(10)
<223>  2'-fluoro modified

<220>  
<221>  modified_base
<222>  (11)..(11)
<223>  2'-O-methyl modified

<220>  
<221>  modified_base
<222>  (12)..(12)
<223>  2'-O-methyl modified

<220>  
<221>  modified_base
<222>  (13)..(13)
<223>  2'-O-methyl modified

<220>  
<221>  modified_base
<222>  (14)..(14)
<223>  2'-fluoro modified

<220>  
<221>  modified_base
<222>  (15)..(15)
<223>  2'-O-methyl modified

<220>  
<221>  modified_base
<222>  (16)..(16)
<223>  2'-O-methyl modified

<220>  
<221>  modified_base
<222>  (17)..(17)
<223>  2'-O-methyl modified

<220>  
<221>  modified_base
<222>  (18)..(18)
<223>  2'-O-methyl modified

<220>  
<221>  modified_base
<222>  (19)..(19)
<223>  2'-O-methyl modified

<220>
<221>  misc_feature
<222>  (20)..(22)
<223>  linked via phosphorothioate

<220>  
<221>  modified_base
<222>  (20)..(20)
<223>  2'-O-methyl modified

<220>  
<221>  modified_base
<222>  (21)..(21)
<223>  2'-O-methyl modified

<220>  
<221>  modified_base
<222>  (22)..(22)
<223>  2'-O-methyl modified

<400>  1064
uuugaugaau uccacuugca gg                                                22


<210>  1065
<211>  22
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  Modified antisense strand


<220>
<221>  misc_feature
<222>  (1)..(4)
<223>  linked via phosphorothioate

<220>  
<221>  modified_base
<222>  (1)..(1)
<223>  5'-methoxyphosphonate-4-oxy modified

<220>  
<221>  modified_base
<222>  (2)..(2)
<223>  2'-fluoro modified

<220>  
<221>  modified_base
<222>  (3)..(3)
<223>  2'-fluoro modified

<220>  
<221>  modified_base
<222>  (4)..(4)
<223>  2'-fluoro modified

<220>  
<221>  modified_base
<222>  (5)..(5)
<223>  2'-fluoro modified

<220>  
<221>  modified_base
<222>  (6)..(6)
<223>  2'-O-methyl modified

<220>  
<221>  modified_base
<222>  (7)..(7)
<223>  2'-fluoro modified

<220>  
<221>  modified_base
<222>  (8)..(8)
<223>  2'-O-methyl modified

<220>  
<221>  modified_base
<222>  (9)..(9)
<223>  2'-O-methyl modified

<220>  
<221>  modified_base
<222>  (10)..(10)
<223>  2'-fluoro modified

<220>  
<221>  modified_base
<222>  (11)..(11)
<223>  2'-O-methyl modified

<220>  
<221>  modified_base
<222>  (12)..(12)
<223>  2'-O-methyl modified

<220>  
<221>  modified_base
<222>  (13)..(13)
<223>  2'-O-methyl modified

<220>  
<221>  modified_base
<222>  (14)..(14)
<223>  2'-fluoro modified

<220>  
<221>  modified_base
<222>  (15)..(15)
<223>  2'-O-methyl modified

<220>  
<221>  modified_base
<222>  (16)..(16)
<223>  2'-O-methyl modified

<220>  
<221>  modified_base
<222>  (17)..(17)
<223>  2'-O-methyl modified

<220>  
<221>  modified_base
<222>  (18)..(18)
<223>  2'-O-methyl modified

<220>  
<221>  modified_base
<222>  (19)..(19)
<223>  2'-O-methyl modified

<220>
<221>  misc_feature
<222>  (20)..(22)
<223>  linked via phosphorothioate

<220>  
<221>  modified_base
<222>  (20)..(20)
<223>  2'-O-methyl modified

<220>  
<221>  modified_base
<222>  (21)..(21)
<223>  2'-O-methyl modified

<220>  
<221>  modified_base
<222>  (22)..(22)
<223>  2'-O-methyl modified

<400>  1065
uguugaugaa uuccacuugc gg                                                22


<210>  1066
<211>  22
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  Modified antisense strand


<220>
<221>  misc_feature
<222>  (1)..(4)
<223>  linked via phosphorothioate

<220>  
<221>  modified_base
<222>  (1)..(1)
<223>  5'-methoxyphosphonate-4-oxy modified

<220>  
<221>  modified_base
<222>  (2)..(2)
<223>  2'-fluoro modified

<220>  
<221>  modified_base
<222>  (3)..(3)
<223>  2'-fluoro modified

<220>  
<221>  modified_base
<222>  (4)..(4)
<223>  2'-fluoro modified

<220>  
<221>  modified_base
<222>  (5)..(5)
<223>  2'-fluoro modified

<220>  
<221>  modified_base
<222>  (6)..(6)
<223>  2'-O-methyl modified

<220>  
<221>  modified_base
<222>  (7)..(7)
<223>  2'-fluoro modified

<220>  
<221>  modified_base
<222>  (8)..(8)
<223>  2'-O-methyl modified

<220>  
<221>  modified_base
<222>  (9)..(9)
<223>  2'-O-methyl modified

<220>  
<221>  modified_base
<222>  (10)..(10)
<223>  2'-fluoro modified

<220>  
<221>  modified_base
<222>  (11)..(11)
<223>  2'-O-methyl modified

<220>  
<221>  modified_base
<222>  (12)..(12)
<223>  2'-O-methyl modified

<220>  
<221>  modified_base
<222>  (13)..(13)
<223>  2'-O-methyl modified

<220>  
<221>  modified_base
<222>  (14)..(14)
<223>  2'-fluoro modified

<220>  
<221>  modified_base
<222>  (15)..(15)
<223>  2'-O-methyl modified

<220>  
<221>  modified_base
<222>  (16)..(16)
<223>  2'-O-methyl modified

<220>  
<221>  modified_base
<222>  (17)..(17)
<223>  2'-O-methyl modified

<220>  
<221>  modified_base
<222>  (18)..(18)
<223>  2'-O-methyl modified

<220>  
<221>  modified_base
<222>  (19)..(19)
<223>  2'-O-methyl modified

<220>
<221>  misc_feature
<222>  (20)..(22)
<223>  linked via phosphorothioate

<220>  
<221>  modified_base
<222>  (20)..(20)
<223>  2'-O-methyl modified

<220>  
<221>  modified_base
<222>  (21)..(21)
<223>  2'-O-methyl modified

<220>  
<221>  modified_base
<222>  (22)..(22)
<223>  2'-O-methyl modified

<400>  1066
ugguugauga auuccacuug gg                                                22


<210>  1067
<211>  22
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  Modified antisense strand


<220>
<221>  misc_feature
<222>  (1)..(4)
<223>  linked via phosphorothioate

<220>  
<221>  modified_base
<222>  (1)..(1)
<223>  5'-methoxyphosphonate-4-oxy modified

<220>  
<221>  modified_base
<222>  (2)..(2)
<223>  2'-fluoro modified

<220>  
<221>  modified_base
<222>  (3)..(3)
<223>  2'-fluoro modified

<220>  
<221>  modified_base
<222>  (4)..(4)
<223>  2'-fluoro modified

<220>  
<221>  modified_base
<222>  (5)..(5)
<223>  2'-fluoro modified

<220>  
<221>  modified_base
<222>  (6)..(6)
<223>  2'-O-methyl modified

<220>  
<221>  modified_base
<222>  (7)..(7)
<223>  2'-fluoro modified

<220>  
<221>  modified_base
<222>  (8)..(8)
<223>  2'-O-methyl modified

<220>  
<221>  modified_base
<222>  (9)..(9)
<223>  2'-O-methyl modified

<220>  
<221>  modified_base
<222>  (10)..(10)
<223>  2'-fluoro modified

<220>  
<221>  modified_base
<222>  (11)..(11)
<223>  2'-O-methyl modified

<220>  
<221>  modified_base
<222>  (12)..(12)
<223>  2'-O-methyl modified

<220>  
<221>  modified_base
<222>  (13)..(13)
<223>  2'-O-methyl modified

<220>  
<221>  modified_base
<222>  (14)..(14)
<223>  2'-fluoro modified

<220>  
<221>  modified_base
<222>  (15)..(15)
<223>  2'-O-methyl modified

<220>  
<221>  modified_base
<222>  (16)..(16)
<223>  2'-O-methyl modified

<220>  
<221>  modified_base
<222>  (17)..(17)
<223>  2'-O-methyl modified

<220>  
<221>  modified_base
<222>  (18)..(18)
<223>  2'-O-methyl modified

<220>  
<221>  modified_base
<222>  (19)..(19)
<223>  2'-O-methyl modified

<220>
<221>  misc_feature
<222>  (20)..(22)
<223>  linked via phosphorothioate

<220>  
<221>  modified_base
<222>  (20)..(20)
<223>  2'-O-methyl modified

<220>  
<221>  modified_base
<222>  (21)..(21)
<223>  2'-O-methyl modified

<220>  
<221>  modified_base
<222>  (22)..(22)
<223>  2'-O-methyl modified

<400>  1067
ugggguugau gaauuccacu gg                                                22


<210>  1068
<211>  22
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  Modified antisense strand


<220>
<221>  misc_feature
<222>  (1)..(4)
<223>  linked via phosphorothioate

<220>  
<221>  modified_base
<222>  (1)..(1)
<223>  5'-methoxyphosphonate-4-oxy modified

<220>  
<221>  modified_base
<222>  (2)..(2)
<223>  2'-fluoro modified

<220>  
<221>  modified_base
<222>  (3)..(3)
<223>  2'-fluoro modified

<220>  
<221>  modified_base
<222>  (4)..(4)
<223>  2'-fluoro modified

<220>  
<221>  modified_base
<222>  (5)..(5)
<223>  2'-fluoro modified

<220>  
<221>  modified_base
<222>  (6)..(6)
<223>  2'-O-methyl modified

<220>  
<221>  modified_base
<222>  (7)..(7)
<223>  2'-fluoro modified

<220>  
<221>  modified_base
<222>  (8)..(8)
<223>  2'-O-methyl modified

<220>  
<221>  modified_base
<222>  (9)..(9)
<223>  2'-O-methyl modified

<220>  
<221>  modified_base
<222>  (10)..(10)
<223>  2'-fluoro modified

<220>  
<221>  modified_base
<222>  (11)..(11)
<223>  2'-O-methyl modified

<220>  
<221>  modified_base
<222>  (12)..(12)
<223>  2'-O-methyl modified

<220>  
<221>  modified_base
<222>  (13)..(13)
<223>  2'-O-methyl modified

<220>  
<221>  modified_base
<222>  (14)..(14)
<223>  2'-fluoro modified

<220>  
<221>  modified_base
<222>  (15)..(15)
<223>  2'-O-methyl modified

<220>  
<221>  modified_base
<222>  (16)..(16)
<223>  2'-O-methyl modified

<220>  
<221>  modified_base
<222>  (17)..(17)
<223>  2'-O-methyl modified

<220>  
<221>  modified_base
<222>  (18)..(18)
<223>  2'-O-methyl modified

<220>  
<221>  modified_base
<222>  (19)..(19)
<223>  2'-O-methyl modified

<220>
<221>  misc_feature
<222>  (20)..(22)
<223>  linked via phosphorothioate

<220>  
<221>  modified_base
<222>  (20)..(20)
<223>  2'-O-methyl modified

<220>  
<221>  modified_base
<222>  (21)..(21)
<223>  2'-O-methyl modified

<220>  
<221>  modified_base
<222>  (22)..(22)
<223>  2'-O-methyl modified

<400>  1068
uugggguuga ugaauuccac gg                                                22


<210>  1069
<211>  22
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  Modified antisense strand


<220>
<221>  misc_feature
<222>  (1)..(4)
<223>  linked via phosphorothioate

<220>  
<221>  modified_base
<222>  (1)..(1)
<223>  5'-methoxyphosphonate-4-oxy modified

<220>  
<221>  modified_base
<222>  (2)..(2)
<223>  2'-fluoro modified

<220>  
<221>  modified_base
<222>  (3)..(3)
<223>  2'-fluoro modified

<220>  
<221>  modified_base
<222>  (4)..(4)
<223>  2'-fluoro modified

<220>  
<221>  modified_base
<222>  (5)..(5)
<223>  2'-fluoro modified

<220>  
<221>  modified_base
<222>  (6)..(6)
<223>  2'-O-methyl modified

<220>  
<221>  modified_base
<222>  (7)..(7)
<223>  2'-fluoro modified

<220>  
<221>  modified_base
<222>  (8)..(8)
<223>  2'-O-methyl modified

<220>  
<221>  modified_base
<222>  (9)..(9)
<223>  2'-O-methyl modified

<220>  
<221>  modified_base
<222>  (10)..(10)
<223>  2'-fluoro modified

<220>  
<221>  modified_base
<222>  (11)..(11)
<223>  2'-O-methyl modified

<220>  
<221>  modified_base
<222>  (12)..(12)
<223>  2'-O-methyl modified

<220>  
<221>  modified_base
<222>  (13)..(13)
<223>  2'-O-methyl modified

<220>  
<221>  modified_base
<222>  (14)..(14)
<223>  2'-fluoro modified

<220>  
<221>  modified_base
<222>  (15)..(15)
<223>  2'-O-methyl modified

<220>  
<221>  modified_base
<222>  (16)..(16)
<223>  2'-O-methyl modified

<220>  
<221>  modified_base
<222>  (17)..(17)
<223>  2'-O-methyl modified

<220>  
<221>  modified_base
<222>  (18)..(18)
<223>  2'-O-methyl modified

<220>  
<221>  modified_base
<222>  (19)..(19)
<223>  2'-O-methyl modified

<220>
<221>  misc_feature
<222>  (20)..(22)
<223>  linked via phosphorothioate

<220>  
<221>  modified_base
<222>  (20)..(20)
<223>  2'-O-methyl modified

<220>  
<221>  modified_base
<222>  (21)..(21)
<223>  2'-O-methyl modified

<220>  
<221>  modified_base
<222>  (22)..(22)
<223>  2'-O-methyl modified

<400>  1069
uaugggguug augaauucca gg                                                22


<210>  1070
<211>  22
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  Modified antisense strand


<220>
<221>  misc_feature
<222>  (1)..(4)
<223>  linked via phosphorothioate

<220>  
<221>  modified_base
<222>  (1)..(1)
<223>  5'-methoxyphosphonate-4-oxy modified

<220>  
<221>  modified_base
<222>  (2)..(2)
<223>  2'-fluoro modified

<220>  
<221>  modified_base
<222>  (3)..(3)
<223>  2'-fluoro modified

<220>  
<221>  modified_base
<222>  (4)..(4)
<223>  2'-fluoro modified

<220>  
<221>  modified_base
<222>  (5)..(5)
<223>  2'-fluoro modified

<220>  
<221>  modified_base
<222>  (6)..(6)
<223>  2'-O-methyl modified

<220>  
<221>  modified_base
<222>  (7)..(7)
<223>  2'-fluoro modified

<220>  
<221>  modified_base
<222>  (8)..(8)
<223>  2'-O-methyl modified

<220>  
<221>  modified_base
<222>  (9)..(9)
<223>  2'-O-methyl modified

<220>  
<221>  modified_base
<222>  (10)..(10)
<223>  2'-fluoro modified

<220>  
<221>  modified_base
<222>  (11)..(11)
<223>  2'-O-methyl modified

<220>  
<221>  modified_base
<222>  (12)..(12)
<223>  2'-O-methyl modified

<220>  
<221>  modified_base
<222>  (13)..(13)
<223>  2'-O-methyl modified

<220>  
<221>  modified_base
<222>  (14)..(14)
<223>  2'-fluoro modified

<220>  
<221>  modified_base
<222>  (15)..(15)
<223>  2'-O-methyl modified

<220>  
<221>  modified_base
<222>  (16)..(16)
<223>  2'-O-methyl modified

<220>  
<221>  modified_base
<222>  (17)..(17)
<223>  2'-O-methyl modified

<220>  
<221>  modified_base
<222>  (18)..(18)
<223>  2'-O-methyl modified

<220>  
<221>  modified_base
<222>  (19)..(19)
<223>  2'-O-methyl modified

<220>
<221>  misc_feature
<222>  (20)..(22)
<223>  linked via phosphorothioate

<220>  
<221>  modified_base
<222>  (20)..(20)
<223>  2'-O-methyl modified

<220>  
<221>  modified_base
<222>  (21)..(21)
<223>  2'-O-methyl modified

<220>  
<221>  modified_base
<222>  (22)..(22)
<223>  2'-O-methyl modified

<400>  1070
uagauggggu ugaugaauuc gg                                                22


<210>  1071
<211>  22
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  Modified antisense strand


<220>
<221>  misc_feature
<222>  (1)..(4)
<223>  linked via phosphorothioate

<220>  
<221>  modified_base
<222>  (1)..(1)
<223>  5'-methoxyphosphonate-4-oxy modified

<220>  
<221>  modified_base
<222>  (2)..(2)
<223>  2'-fluoro modified

<220>  
<221>  modified_base
<222>  (3)..(3)
<223>  2'-fluoro modified

<220>  
<221>  modified_base
<222>  (4)..(4)
<223>  2'-fluoro modified

<220>  
<221>  modified_base
<222>  (5)..(5)
<223>  2'-fluoro modified

<220>  
<221>  modified_base
<222>  (6)..(6)
<223>  2'-O-methyl modified

<220>  
<221>  modified_base
<222>  (7)..(7)
<223>  2'-fluoro modified

<220>  
<221>  modified_base
<222>  (8)..(8)
<223>  2'-O-methyl modified

<220>  
<221>  modified_base
<222>  (9)..(9)
<223>  2'-O-methyl modified

<220>  
<221>  modified_base
<222>  (10)..(10)
<223>  2'-fluoro modified

<220>  
<221>  modified_base
<222>  (11)..(11)
<223>  2'-O-methyl modified

<220>  
<221>  modified_base
<222>  (12)..(12)
<223>  2'-O-methyl modified

<220>  
<221>  modified_base
<222>  (13)..(13)
<223>  2'-O-methyl modified

<220>  
<221>  modified_base
<222>  (14)..(14)
<223>  2'-fluoro modified

<220>  
<221>  modified_base
<222>  (15)..(15)
<223>  2'-O-methyl modified

<220>  
<221>  modified_base
<222>  (16)..(16)
<223>  2'-O-methyl modified

<220>  
<221>  modified_base
<222>  (17)..(17)
<223>  2'-O-methyl modified

<220>  
<221>  modified_base
<222>  (18)..(18)
<223>  2'-O-methyl modified

<220>  
<221>  modified_base
<222>  (19)..(19)
<223>  2'-O-methyl modified

<220>
<221>  misc_feature
<222>  (20)..(22)
<223>  linked via phosphorothioate

<220>  
<221>  modified_base
<222>  (20)..(20)
<223>  2'-O-methyl modified

<220>  
<221>  modified_base
<222>  (21)..(21)
<223>  2'-O-methyl modified

<220>  
<221>  modified_base
<222>  (22)..(22)
<223>  2'-O-methyl modified

<400>  1071
uaagaugggg uugaugaauu gg                                                22


<210>  1072
<211>  22
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  Modified antisense strand


<220>
<221>  misc_feature
<222>  (1)..(3)
<223>  linked via phosphorothioate

<220>  
<221>  modified_base
<222>  (1)..(1)
<223>  5'-methoxyphosphonate-4-oxy modified

<220>  
<221>  modified_base
<222>  (2)..(2)
<223>  2'-fluoro modified

<220>  
<221>  modified_base
<222>  (3)..(3)
<223>  2'-fluoro modified

<220>  
<221>  modified_base
<222>  (4)..(4)
<223>  2'-fluoro modified

<220>  
<221>  modified_base
<222>  (5)..(5)
<223>  2'-fluoro modified

<220>  
<221>  modified_base
<222>  (6)..(6)
<223>  2'-O-methyl modified

<220>  
<221>  modified_base
<222>  (7)..(7)
<223>  2'-fluoro modified

<220>  
<221>  modified_base
<222>  (8)..(8)
<223>  2'-O-methyl modified

<220>  
<221>  modified_base
<222>  (9)..(9)
<223>  2'-O-methyl modified

<220>  
<221>  modified_base
<222>  (10)..(10)
<223>  2'-fluoro modified

<220>  
<221>  modified_base
<222>  (11)..(11)
<223>  2'-O-methyl modified

<220>  
<221>  modified_base
<222>  (12)..(12)
<223>  2'-O-methyl modified

<220>  
<221>  modified_base
<222>  (13)..(13)
<223>  2'-O-methyl modified

<220>  
<221>  modified_base
<222>  (14)..(14)
<223>  2'-fluoro modified

<220>  
<221>  modified_base
<222>  (15)..(15)
<223>  2'-O-methyl modified

<220>  
<221>  modified_base
<222>  (16)..(16)
<223>  2'-O-methyl modified

<220>  
<221>  modified_base
<222>  (17)..(17)
<223>  2'-O-methyl modified

<220>  
<221>  modified_base
<222>  (18)..(18)
<223>  2'-O-methyl modified

<220>  
<221>  modified_base
<222>  (19)..(19)
<223>  2'-O-methyl modified

<220>
<221>  misc_feature
<222>  (20)..(22)
<223>  linked via phosphorothioate

<220>  
<221>  modified_base
<222>  (20)..(20)
<223>  2'-O-methyl modified

<220>  
<221>  modified_base
<222>  (21)..(21)
<223>  2'-O-methyl modified

<220>  
<221>  modified_base
<222>  (22)..(22)
<223>  2'-O-methyl modified

<400>  1072
ugaagauggg guugaugaau gg                                                22


<210>  1073
<211>  22
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  Modified antisense strand


<220>
<221>  misc_feature
<222>  (1)..(4)
<223>  linked via phosphorothioate

<220>  
<221>  modified_base
<222>  (1)..(1)
<223>  5'-methoxyphosphonate-4-oxy modified

<220>  
<221>  modified_base
<222>  (2)..(2)
<223>  2'-fluoro modified

<220>  
<221>  modified_base
<222>  (3)..(3)
<223>  2'-fluoro modified

<220>  
<221>  modified_base
<222>  (4)..(4)
<223>  2'-fluoro modified

<220>  
<221>  modified_base
<222>  (5)..(5)
<223>  2'-fluoro modified

<220>  
<221>  modified_base
<222>  (6)..(6)
<223>  2'-O-methyl modified

<220>  
<221>  modified_base
<222>  (7)..(7)
<223>  2'-fluoro modified

<220>  
<221>  modified_base
<222>  (8)..(8)
<223>  2'-O-methyl modified

<220>  
<221>  modified_base
<222>  (9)..(9)
<223>  2'-O-methyl modified

<220>  
<221>  modified_base
<222>  (10)..(10)
<223>  2'-fluoro modified

<220>  
<221>  modified_base
<222>  (11)..(11)
<223>  2'-O-methyl modified

<220>  
<221>  modified_base
<222>  (12)..(12)
<223>  2'-O-methyl modified

<220>  
<221>  modified_base
<222>  (13)..(13)
<223>  2'-O-methyl modified

<220>  
<221>  modified_base
<222>  (14)..(14)
<223>  2'-fluoro modified

<220>  
<221>  modified_base
<222>  (15)..(15)
<223>  2'-O-methyl modified

<220>  
<221>  modified_base
<222>  (16)..(16)
<223>  2'-O-methyl modified

<220>  
<221>  modified_base
<222>  (17)..(17)
<223>  2'-O-methyl modified

<220>  
<221>  modified_base
<222>  (18)..(18)
<223>  2'-O-methyl modified

<220>  
<221>  modified_base
<222>  (19)..(19)
<223>  2'-O-methyl modified

<220>
<221>  misc_feature
<222>  (20)..(22)
<223>  linked via phosphorothioate

<220>  
<221>  modified_base
<222>  (20)..(20)
<223>  2'-O-methyl modified

<220>  
<221>  modified_base
<222>  (21)..(21)
<223>  2'-O-methyl modified

<220>  
<221>  modified_base
<222>  (22)..(22)
<223>  2'-O-methyl modified

<400>  1073
ucgaagaugg gguugaugaa gg                                                22


<210>  1074
<211>  22
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  Modified antisense strand


<220>
<221>  misc_feature
<222>  (1)..(4)
<223>  linked via phosphorothioate

<220>  
<221>  modified_base
<222>  (1)..(1)
<223>  5'-methoxyphosphonate-4-oxy modified

<220>  
<221>  modified_base
<222>  (2)..(2)
<223>  2'-fluoro modified

<220>  
<221>  modified_base
<222>  (3)..(3)
<223>  2'-fluoro modified

<220>  
<221>  modified_base
<222>  (4)..(4)
<223>  2'-fluoro modified

<220>  
<221>  modified_base
<222>  (5)..(5)
<223>  2'-fluoro modified

<220>  
<221>  modified_base
<222>  (6)..(6)
<223>  2'-O-methyl modified

<220>  
<221>  modified_base
<222>  (7)..(7)
<223>  2'-fluoro modified

<220>  
<221>  modified_base
<222>  (8)..(8)
<223>  2'-O-methyl modified

<220>  
<221>  modified_base
<222>  (9)..(9)
<223>  2'-O-methyl modified

<220>  
<221>  modified_base
<222>  (10)..(10)
<223>  2'-fluoro modified

<220>  
<221>  modified_base
<222>  (11)..(11)
<223>  2'-O-methyl modified

<220>  
<221>  modified_base
<222>  (12)..(12)
<223>  2'-O-methyl modified

<220>  
<221>  modified_base
<222>  (13)..(13)
<223>  2'-O-methyl modified

<220>  
<221>  modified_base
<222>  (14)..(14)
<223>  2'-fluoro modified

<220>  
<221>  modified_base
<222>  (15)..(15)
<223>  2'-O-methyl modified

<220>  
<221>  modified_base
<222>  (16)..(16)
<223>  2'-O-methyl modified

<220>  
<221>  modified_base
<222>  (17)..(17)
<223>  2'-O-methyl modified

<220>  
<221>  modified_base
<222>  (18)..(18)
<223>  2'-O-methyl modified

<220>  
<221>  modified_base
<222>  (19)..(19)
<223>  2'-O-methyl modified

<220>
<221>  misc_feature
<222>  (20)..(22)
<223>  linked via phosphorothioate

<220>  
<221>  modified_base
<222>  (20)..(20)
<223>  2'-O-methyl modified

<220>  
<221>  modified_base
<222>  (21)..(21)
<223>  2'-O-methyl modified

<220>  
<221>  modified_base
<222>  (22)..(22)
<223>  2'-O-methyl modified

<400>  1074
uuccacauau gugugcugca gg                                                22


<210>  1075
<211>  22
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  Modified antisense strand


<220>
<221>  misc_feature
<222>  (1)..(4)
<223>  linked via phosphorothioate

<220>  
<221>  modified_base
<222>  (1)..(1)
<223>  5'-methoxyphosphonate-4-oxy modified

<220>  
<221>  modified_base
<222>  (2)..(2)
<223>  2'-fluoro modified

<220>  
<221>  modified_base
<222>  (3)..(3)
<223>  2'-fluoro modified

<220>  
<221>  modified_base
<222>  (4)..(4)
<223>  2'-fluoro modified

<220>  
<221>  modified_base
<222>  (5)..(5)
<223>  2'-fluoro modified

<220>  
<221>  modified_base
<222>  (6)..(6)
<223>  2'-O-methyl modified

<220>  
<221>  modified_base
<222>  (7)..(7)
<223>  2'-fluoro modified

<220>  
<221>  modified_base
<222>  (8)..(8)
<223>  2'-O-methyl modified

<220>  
<221>  modified_base
<222>  (9)..(9)
<223>  2'-O-methyl modified

<220>  
<221>  modified_base
<222>  (10)..(10)
<223>  2'-fluoro modified

<220>  
<221>  modified_base
<222>  (11)..(11)
<223>  2'-O-methyl modified

<220>  
<221>  modified_base
<222>  (12)..(12)
<223>  2'-O-methyl modified

<220>  
<221>  modified_base
<222>  (13)..(13)
<223>  2'-O-methyl modified

<220>  
<221>  modified_base
<222>  (14)..(14)
<223>  2'-fluoro modified

<220>  
<221>  modified_base
<222>  (15)..(15)
<223>  2'-O-methyl modified

<220>  
<221>  modified_base
<222>  (16)..(16)
<223>  2'-O-methyl modified

<220>  
<221>  modified_base
<222>  (17)..(17)
<223>  2'-O-methyl modified

<220>  
<221>  modified_base
<222>  (18)..(18)
<223>  2'-O-methyl modified

<220>  
<221>  modified_base
<222>  (19)..(19)
<223>  2'-O-methyl modified

<220>
<221>  misc_feature
<222>  (20)..(22)
<223>  linked via phosphorothioate

<220>  
<221>  modified_base
<222>  (20)..(20)
<223>  2'-O-methyl modified

<220>  
<221>  modified_base
<222>  (21)..(21)
<223>  2'-O-methyl modified

<220>  
<221>  modified_base
<222>  (22)..(22)
<223>  2'-O-methyl modified

<400>  1075
uggcuuccac auaugugugc gg                                                22


<210>  1076
<211>  22
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  Modified antisense strand


<220>
<221>  misc_feature
<222>  (1)..(4)
<223>  linked via phosphorothioate

<220>  
<221>  modified_base
<222>  (1)..(1)
<223>  5'-methoxyphosphonate-4-oxy modified

<220>  
<221>  modified_base
<222>  (2)..(2)
<223>  2'-fluoro modified

<220>  
<221>  modified_base
<222>  (3)..(3)
<223>  2'-fluoro modified

<220>  
<221>  modified_base
<222>  (4)..(4)
<223>  2'-fluoro modified

<220>  
<221>  modified_base
<222>  (5)..(5)
<223>  2'-fluoro modified

<220>  
<221>  modified_base
<222>  (6)..(6)
<223>  2'-O-methyl modified

<220>  
<221>  modified_base
<222>  (7)..(7)
<223>  2'-fluoro modified

<220>  
<221>  modified_base
<222>  (8)..(8)
<223>  2'-O-methyl modified

<220>  
<221>  modified_base
<222>  (9)..(9)
<223>  2'-O-methyl modified

<220>  
<221>  modified_base
<222>  (10)..(10)
<223>  2'-fluoro modified

<220>  
<221>  modified_base
<222>  (11)..(11)
<223>  2'-O-methyl modified

<220>  
<221>  modified_base
<222>  (12)..(12)
<223>  2'-O-methyl modified

<220>  
<221>  modified_base
<222>  (13)..(13)
<223>  2'-O-methyl modified

<220>  
<221>  modified_base
<222>  (14)..(14)
<223>  2'-fluoro modified

<220>  
<221>  modified_base
<222>  (15)..(15)
<223>  2'-O-methyl modified

<220>  
<221>  modified_base
<222>  (16)..(16)
<223>  2'-O-methyl modified

<220>  
<221>  modified_base
<222>  (17)..(17)
<223>  2'-O-methyl modified

<220>  
<221>  modified_base
<222>  (18)..(18)
<223>  2'-O-methyl modified

<220>  
<221>  modified_base
<222>  (19)..(19)
<223>  2'-O-methyl modified

<220>
<221>  misc_feature
<222>  (20)..(22)
<223>  linked via phosphorothioate

<220>  
<221>  modified_base
<222>  (20)..(20)
<223>  2'-O-methyl modified

<220>  
<221>  modified_base
<222>  (21)..(21)
<223>  2'-O-methyl modified

<220>  
<221>  modified_base
<222>  (22)..(22)
<223>  2'-O-methyl modified

<400>  1076
uauggagacg uaggcaugca gg                                                22


<210>  1077
<211>  22
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  Modified antisense strand


<220>
<221>  misc_feature
<222>  (1)..(4)
<223>  linked via phosphorothioate

<220>  
<221>  modified_base
<222>  (1)..(1)
<223>  5'-methoxyphosphonate-4-oxy modified

<220>  
<221>  modified_base
<222>  (2)..(2)
<223>  2'-fluoro modified

<220>  
<221>  modified_base
<222>  (3)..(3)
<223>  2'-fluoro modified

<220>  
<221>  modified_base
<222>  (4)..(4)
<223>  2'-fluoro modified

<220>  
<221>  modified_base
<222>  (5)..(5)
<223>  2'-fluoro modified

<220>  
<221>  modified_base
<222>  (6)..(6)
<223>  2'-O-methyl modified

<220>  
<221>  modified_base
<222>  (7)..(7)
<223>  2'-fluoro modified

<220>  
<221>  modified_base
<222>  (8)..(8)
<223>  2'-O-methyl modified

<220>  
<221>  modified_base
<222>  (9)..(9)
<223>  2'-O-methyl modified

<220>  
<221>  modified_base
<222>  (10)..(10)
<223>  2'-fluoro modified

<220>  
<221>  modified_base
<222>  (11)..(11)
<223>  2'-O-methyl modified

<220>  
<221>  modified_base
<222>  (12)..(12)
<223>  2'-O-methyl modified

<220>  
<221>  modified_base
<222>  (13)..(13)
<223>  2'-O-methyl modified

<220>  
<221>  modified_base
<222>  (14)..(14)
<223>  2'-fluoro modified

<220>  
<221>  modified_base
<222>  (15)..(15)
<223>  2'-O-methyl modified

<220>  
<221>  modified_base
<222>  (16)..(16)
<223>  2'-O-methyl modified

<220>  
<221>  modified_base
<222>  (17)..(17)
<223>  2'-O-methyl modified

<220>  
<221>  modified_base
<222>  (18)..(18)
<223>  2'-O-methyl modified

<220>  
<221>  modified_base
<222>  (19)..(19)
<223>  2'-O-methyl modified

<220>
<221>  misc_feature
<222>  (20)..(22)
<223>  linked via phosphorothioate

<220>  
<221>  modified_base
<222>  (20)..(20)
<223>  2'-O-methyl modified

<220>  
<221>  modified_base
<222>  (21)..(21)
<223>  2'-O-methyl modified

<220>  
<221>  modified_base
<222>  (22)..(22)
<223>  2'-O-methyl modified

<400>  1077
uguggaugga gacguaggca gg                                                22


<210>  1078
<211>  22
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  Modified antisense strand


<220>
<221>  misc_feature
<222>  (1)..(4)
<223>  linked via phosphorothioate

<220>  
<221>  modified_base
<222>  (1)..(1)
<223>  5'-methoxyphosphonate-4-oxy modified

<220>  
<221>  modified_base
<222>  (2)..(2)
<223>  2'-fluoro modified

<220>  
<221>  modified_base
<222>  (3)..(3)
<223>  2'-fluoro modified

<220>  
<221>  modified_base
<222>  (4)..(4)
<223>  2'-fluoro modified

<220>  
<221>  modified_base
<222>  (5)..(5)
<223>  2'-fluoro modified

<220>  
<221>  modified_base
<222>  (6)..(6)
<223>  2'-O-methyl modified

<220>  
<221>  modified_base
<222>  (7)..(7)
<223>  2'-fluoro modified

<220>  
<221>  modified_base
<222>  (8)..(8)
<223>  2'-O-methyl modified

<220>  
<221>  modified_base
<222>  (9)..(9)
<223>  2'-O-methyl modified

<220>  
<221>  modified_base
<222>  (10)..(10)
<223>  2'-fluoro modified

<220>  
<221>  modified_base
<222>  (11)..(11)
<223>  2'-O-methyl modified

<220>  
<221>  modified_base
<222>  (12)..(12)
<223>  2'-O-methyl modified

<220>  
<221>  modified_base
<222>  (13)..(13)
<223>  2'-O-methyl modified

<220>  
<221>  modified_base
<222>  (14)..(14)
<223>  2'-fluoro modified

<220>  
<221>  modified_base
<222>  (15)..(15)
<223>  2'-O-methyl modified

<220>  
<221>  modified_base
<222>  (16)..(16)
<223>  2'-O-methyl modified

<220>  
<221>  modified_base
<222>  (17)..(17)
<223>  2'-O-methyl modified

<220>  
<221>  modified_base
<222>  (18)..(18)
<223>  2'-O-methyl modified

<220>  
<221>  modified_base
<222>  (19)..(19)
<223>  2'-O-methyl modified

<220>
<221>  misc_feature
<222>  (20)..(22)
<223>  linked via phosphorothioate

<220>  
<221>  modified_base
<222>  (20)..(20)
<223>  2'-O-methyl modified

<220>  
<221>  modified_base
<222>  (21)..(21)
<223>  2'-O-methyl modified

<220>  
<221>  modified_base
<222>  (22)..(22)
<223>  2'-O-methyl modified

<400>  1078
ugauggugga uggagacgua gg                                                22


<210>  1079
<211>  22
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  Modified antisense strand


<220>
<221>  misc_feature
<222>  (1)..(4)
<223>  linked via phosphorothioate

<220>  
<221>  modified_base
<222>  (1)..(1)
<223>  5'-methoxyphosphonate-4-oxy modified

<220>  
<221>  modified_base
<222>  (2)..(2)
<223>  2'-fluoro modified

<220>  
<221>  modified_base
<222>  (3)..(3)
<223>  2'-fluoro modified

<220>  
<221>  modified_base
<222>  (4)..(4)
<223>  2'-fluoro modified

<220>  
<221>  modified_base
<222>  (5)..(5)
<223>  2'-fluoro modified

<220>  
<221>  modified_base
<222>  (6)..(6)
<223>  2'-O-methyl modified

<220>  
<221>  modified_base
<222>  (7)..(7)
<223>  2'-fluoro modified

<220>  
<221>  modified_base
<222>  (8)..(8)
<223>  2'-O-methyl modified

<220>  
<221>  modified_base
<222>  (9)..(9)
<223>  2'-O-methyl modified

<220>  
<221>  modified_base
<222>  (10)..(10)
<223>  2'-fluoro modified

<220>  
<221>  modified_base
<222>  (11)..(11)
<223>  2'-O-methyl modified

<220>  
<221>  modified_base
<222>  (12)..(12)
<223>  2'-O-methyl modified

<220>  
<221>  modified_base
<222>  (13)..(13)
<223>  2'-O-methyl modified

<220>  
<221>  modified_base
<222>  (14)..(14)
<223>  2'-fluoro modified

<220>  
<221>  modified_base
<222>  (15)..(15)
<223>  2'-O-methyl modified

<220>  
<221>  modified_base
<222>  (16)..(16)
<223>  2'-O-methyl modified

<220>  
<221>  modified_base
<222>  (17)..(17)
<223>  2'-O-methyl modified

<220>  
<221>  modified_base
<222>  (18)..(18)
<223>  2'-O-methyl modified

<220>  
<221>  modified_base
<222>  (19)..(19)
<223>  2'-O-methyl modified

<220>
<221>  misc_feature
<222>  (20)..(22)
<223>  linked via phosphorothioate

<220>  
<221>  modified_base
<222>  (20)..(20)
<223>  2'-O-methyl modified

<220>  
<221>  modified_base
<222>  (21)..(21)
<223>  2'-O-methyl modified

<220>  
<221>  modified_base
<222>  (22)..(22)
<223>  2'-O-methyl modified

<400>  1079
ugggauggug gauggagacg gg                                                22


<210>  1080
<211>  22
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  Modified antisense strand


<220>
<221>  misc_feature
<222>  (1)..(4)
<223>  linked via phosphorothioate

<220>  
<221>  modified_base
<222>  (1)..(1)
<223>  5'-methoxyphosphonate-4-oxy modified

<220>  
<221>  modified_base
<222>  (2)..(2)
<223>  2'-fluoro modified

<220>  
<221>  modified_base
<222>  (3)..(3)
<223>  2'-fluoro modified

<220>  
<221>  modified_base
<222>  (4)..(4)
<223>  2'-fluoro modified

<220>  
<221>  modified_base
<222>  (5)..(5)
<223>  2'-fluoro modified

<220>  
<221>  modified_base
<222>  (6)..(6)
<223>  2'-O-methyl modified

<220>  
<221>  modified_base
<222>  (7)..(7)
<223>  2'-fluoro modified

<220>  
<221>  modified_base
<222>  (8)..(8)
<223>  2'-O-methyl modified

<220>  
<221>  modified_base
<222>  (9)..(9)
<223>  2'-O-methyl modified

<220>  
<221>  modified_base
<222>  (10)..(10)
<223>  2'-fluoro modified

<220>  
<221>  modified_base
<222>  (11)..(11)
<223>  2'-O-methyl modified

<220>  
<221>  modified_base
<222>  (12)..(12)
<223>  2'-O-methyl modified

<220>  
<221>  modified_base
<222>  (13)..(13)
<223>  2'-O-methyl modified

<220>  
<221>  modified_base
<222>  (14)..(14)
<223>  2'-fluoro modified

<220>  
<221>  modified_base
<222>  (15)..(15)
<223>  2'-O-methyl modified

<220>  
<221>  modified_base
<222>  (16)..(16)
<223>  2'-O-methyl modified

<220>  
<221>  modified_base
<222>  (17)..(17)
<223>  2'-O-methyl modified

<220>  
<221>  modified_base
<222>  (18)..(18)
<223>  2'-O-methyl modified

<220>  
<221>  modified_base
<222>  (19)..(19)
<223>  2'-O-methyl modified

<220>
<221>  misc_feature
<222>  (20)..(22)
<223>  linked via phosphorothioate

<220>  
<221>  modified_base
<222>  (20)..(20)
<223>  2'-O-methyl modified

<220>  
<221>  modified_base
<222>  (21)..(21)
<223>  2'-O-methyl modified

<220>  
<221>  modified_base
<222>  (22)..(22)
<223>  2'-O-methyl modified

<400>  1080
uggucauggg gaugguggau gg                                                22


<210>  1081
<211>  22
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  Modified antisense strand


<220>
<221>  misc_feature
<222>  (1)..(4)
<223>  linked via phosphorothioate

<220>  
<221>  modified_base
<222>  (1)..(1)
<223>  5'-methoxyphosphonate-4-oxy modified

<220>  
<221>  modified_base
<222>  (2)..(2)
<223>  2'-fluoro modified

<220>  
<221>  modified_base
<222>  (3)..(3)
<223>  2'-fluoro modified

<220>  
<221>  modified_base
<222>  (4)..(4)
<223>  2'-fluoro modified

<220>  
<221>  modified_base
<222>  (5)..(5)
<223>  2'-fluoro modified

<220>  
<221>  modified_base
<222>  (6)..(6)
<223>  2'-O-methyl modified

<220>  
<221>  modified_base
<222>  (7)..(7)
<223>  2'-fluoro modified

<220>  
<221>  modified_base
<222>  (8)..(8)
<223>  2'-O-methyl modified

<220>  
<221>  modified_base
<222>  (9)..(9)
<223>  2'-O-methyl modified

<220>  
<221>  modified_base
<222>  (10)..(10)
<223>  2'-fluoro modified

<220>  
<221>  modified_base
<222>  (11)..(11)
<223>  2'-O-methyl modified

<220>  
<221>  modified_base
<222>  (12)..(12)
<223>  2'-O-methyl modified

<220>  
<221>  modified_base
<222>  (13)..(13)
<223>  2'-O-methyl modified

<220>  
<221>  modified_base
<222>  (14)..(14)
<223>  2'-fluoro modified

<220>  
<221>  modified_base
<222>  (15)..(15)
<223>  2'-O-methyl modified

<220>  
<221>  modified_base
<222>  (16)..(16)
<223>  2'-O-methyl modified

<220>  
<221>  modified_base
<222>  (17)..(17)
<223>  2'-O-methyl modified

<220>  
<221>  modified_base
<222>  (18)..(18)
<223>  2'-O-methyl modified

<220>  
<221>  modified_base
<222>  (19)..(19)
<223>  2'-O-methyl modified

<220>
<221>  misc_feature
<222>  (20)..(22)
<223>  linked via phosphorothioate

<220>  
<221>  modified_base
<222>  (20)..(20)
<223>  2'-O-methyl modified

<220>  
<221>  modified_base
<222>  (21)..(21)
<223>  2'-O-methyl modified

<220>  
<221>  modified_base
<222>  (22)..(22)
<223>  2'-O-methyl modified

<400>  1081
uggaacauca gucggucaug gg                                                22


<210>  1082
<211>  22
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  Modified antisense strand


<220>
<221>  misc_feature
<222>  (1)..(4)
<223>  linked via phosphorothioate

<220>  
<221>  modified_base
<222>  (1)..(1)
<223>  5'-methoxyphosphonate-4-oxy modified

<220>  
<221>  modified_base
<222>  (2)..(2)
<223>  2'-fluoro modified

<220>  
<221>  modified_base
<222>  (3)..(3)
<223>  2'-fluoro modified

<220>  
<221>  modified_base
<222>  (4)..(4)
<223>  2'-fluoro modified

<220>  
<221>  modified_base
<222>  (5)..(5)
<223>  2'-fluoro modified

<220>  
<221>  modified_base
<222>  (6)..(6)
<223>  2'-O-methyl modified

<220>  
<221>  modified_base
<222>  (7)..(7)
<223>  2'-fluoro modified

<220>  
<221>  modified_base
<222>  (8)..(8)
<223>  2'-O-methyl modified

<220>  
<221>  modified_base
<222>  (9)..(9)
<223>  2'-O-methyl modified

<220>  
<221>  modified_base
<222>  (10)..(10)
<223>  2'-fluoro modified

<220>  
<221>  modified_base
<222>  (11)..(11)
<223>  2'-O-methyl modified

<220>  
<221>  modified_base
<222>  (12)..(12)
<223>  2'-O-methyl modified

<220>  
<221>  modified_base
<222>  (13)..(13)
<223>  2'-O-methyl modified

<220>  
<221>  modified_base
<222>  (14)..(14)
<223>  2'-fluoro modified

<220>  
<221>  modified_base
<222>  (15)..(15)
<223>  2'-O-methyl modified

<220>  
<221>  modified_base
<222>  (16)..(16)
<223>  2'-O-methyl modified

<220>  
<221>  modified_base
<222>  (17)..(17)
<223>  2'-O-methyl modified

<220>  
<221>  modified_base
<222>  (18)..(18)
<223>  2'-O-methyl modified

<220>  
<221>  modified_base
<222>  (19)..(19)
<223>  2'-O-methyl modified

<220>
<221>  misc_feature
<222>  (20)..(22)
<223>  linked via phosphorothioate

<220>  
<221>  modified_base
<222>  (20)..(20)
<223>  2'-O-methyl modified

<220>  
<221>  modified_base
<222>  (21)..(21)
<223>  2'-O-methyl modified

<220>  
<221>  modified_base
<222>  (22)..(22)
<223>  2'-O-methyl modified

<400>  1082
uccgugggaa caucagucgg gg                                                22


<210>  1083
<211>  22
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  Modified antisense strand


<220>
<221>  misc_feature
<222>  (1)..(4)
<223>  linked via phosphorothioate

<220>  
<221>  modified_base
<222>  (1)..(1)
<223>  5'-methoxyphosphonate-4-oxy modified

<220>  
<221>  modified_base
<222>  (2)..(2)
<223>  2'-fluoro modified

<220>  
<221>  modified_base
<222>  (3)..(3)
<223>  2'-fluoro modified

<220>  
<221>  modified_base
<222>  (4)..(4)
<223>  2'-fluoro modified

<220>  
<221>  modified_base
<222>  (5)..(5)
<223>  2'-fluoro modified

<220>  
<221>  modified_base
<222>  (6)..(6)
<223>  2'-O-methyl modified

<220>  
<221>  modified_base
<222>  (7)..(7)
<223>  2'-fluoro modified

<220>  
<221>  modified_base
<222>  (8)..(8)
<223>  2'-O-methyl modified

<220>  
<221>  modified_base
<222>  (9)..(9)
<223>  2'-O-methyl modified

<220>  
<221>  modified_base
<222>  (10)..(10)
<223>  2'-fluoro modified

<220>  
<221>  modified_base
<222>  (11)..(11)
<223>  2'-O-methyl modified

<220>  
<221>  modified_base
<222>  (12)..(12)
<223>  2'-O-methyl modified

<220>  
<221>  modified_base
<222>  (13)..(13)
<223>  2'-O-methyl modified

<220>  
<221>  modified_base
<222>  (14)..(14)
<223>  2'-fluoro modified

<220>  
<221>  modified_base
<222>  (15)..(15)
<223>  2'-O-methyl modified

<220>  
<221>  modified_base
<222>  (16)..(16)
<223>  2'-O-methyl modified

<220>  
<221>  modified_base
<222>  (17)..(17)
<223>  2'-O-methyl modified

<220>  
<221>  modified_base
<222>  (18)..(18)
<223>  2'-O-methyl modified

<220>  
<221>  modified_base
<222>  (19)..(19)
<223>  2'-O-methyl modified

<220>
<221>  misc_feature
<222>  (20)..(22)
<223>  linked via phosphorothioate

<220>  
<221>  modified_base
<222>  (20)..(20)
<223>  2'-O-methyl modified

<220>  
<221>  modified_base
<222>  (21)..(21)
<223>  2'-O-methyl modified

<220>  
<221>  modified_base
<222>  (22)..(22)
<223>  2'-O-methyl modified

<400>  1083
uuccguggga acaucagucg gg                                                22


<210>  1084
<211>  22
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  Modified antisense strand


<220>
<221>  misc_feature
<222>  (1)..(4)
<223>  linked via phosphorothioate

<220>  
<221>  modified_base
<222>  (1)..(1)
<223>  5'-methoxyphosphonate-4-oxy modified

<220>  
<221>  modified_base
<222>  (2)..(2)
<223>  2'-fluoro modified

<220>  
<221>  modified_base
<222>  (3)..(3)
<223>  2'-fluoro modified

<220>  
<221>  modified_base
<222>  (4)..(4)
<223>  2'-fluoro modified

<220>  
<221>  modified_base
<222>  (5)..(5)
<223>  2'-fluoro modified

<220>  
<221>  modified_base
<222>  (6)..(6)
<223>  2'-O-methyl modified

<220>  
<221>  modified_base
<222>  (7)..(7)
<223>  2'-fluoro modified

<220>  
<221>  modified_base
<222>  (8)..(8)
<223>  2'-O-methyl modified

<220>  
<221>  modified_base
<222>  (9)..(9)
<223>  2'-O-methyl modified

<220>  
<221>  modified_base
<222>  (10)..(10)
<223>  2'-fluoro modified

<220>  
<221>  modified_base
<222>  (11)..(11)
<223>  2'-O-methyl modified

<220>  
<221>  modified_base
<222>  (12)..(12)
<223>  2'-O-methyl modified

<220>  
<221>  modified_base
<222>  (13)..(13)
<223>  2'-O-methyl modified

<220>  
<221>  modified_base
<222>  (14)..(14)
<223>  2'-fluoro modified

<220>  
<221>  modified_base
<222>  (15)..(15)
<223>  2'-O-methyl modified

<220>  
<221>  modified_base
<222>  (16)..(16)
<223>  2'-O-methyl modified

<220>  
<221>  modified_base
<222>  (17)..(17)
<223>  2'-O-methyl modified

<220>  
<221>  modified_base
<222>  (18)..(18)
<223>  2'-O-methyl modified

<220>  
<221>  modified_base
<222>  (19)..(19)
<223>  2'-O-methyl modified

<220>
<221>  misc_feature
<222>  (20)..(22)
<223>  linked via phosphorothioate

<220>  
<221>  modified_base
<222>  (20)..(20)
<223>  2'-O-methyl modified

<220>  
<221>  modified_base
<222>  (21)..(21)
<223>  2'-O-methyl modified

<220>  
<221>  modified_base
<222>  (22)..(22)
<223>  2'-O-methyl modified

<400>  1084
uauccguggg aacaucaguc gg                                                22


<210>  1085
<211>  22
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  Modified antisense strand


<220>
<221>  misc_feature
<222>  (1)..(4)
<223>  linked via phosphorothioate

<220>  
<221>  modified_base
<222>  (1)..(1)
<223>  5'-methoxyphosphonate-4-oxy modified

<220>  
<221>  modified_base
<222>  (2)..(2)
<223>  2'-fluoro modified

<220>  
<221>  modified_base
<222>  (3)..(3)
<223>  2'-fluoro modified

<220>  
<221>  modified_base
<222>  (4)..(4)
<223>  2'-fluoro modified

<220>  
<221>  modified_base
<222>  (5)..(5)
<223>  2'-fluoro modified

<220>  
<221>  modified_base
<222>  (6)..(6)
<223>  2'-O-methyl modified

<220>  
<221>  modified_base
<222>  (7)..(7)
<223>  2'-fluoro modified

<220>  
<221>  modified_base
<222>  (8)..(8)
<223>  2'-O-methyl modified

<220>  
<221>  modified_base
<222>  (9)..(9)
<223>  2'-O-methyl modified

<220>  
<221>  modified_base
<222>  (10)..(10)
<223>  2'-fluoro modified

<220>  
<221>  modified_base
<222>  (11)..(11)
<223>  2'-O-methyl modified

<220>  
<221>  modified_base
<222>  (12)..(12)
<223>  2'-O-methyl modified

<220>  
<221>  modified_base
<222>  (13)..(13)
<223>  2'-O-methyl modified

<220>  
<221>  modified_base
<222>  (14)..(14)
<223>  2'-fluoro modified

<220>  
<221>  modified_base
<222>  (15)..(15)
<223>  2'-O-methyl modified

<220>  
<221>  modified_base
<222>  (16)..(16)
<223>  2'-O-methyl modified

<220>  
<221>  modified_base
<222>  (17)..(17)
<223>  2'-O-methyl modified

<220>  
<221>  modified_base
<222>  (18)..(18)
<223>  2'-O-methyl modified

<220>  
<221>  modified_base
<222>  (19)..(19)
<223>  2'-O-methyl modified

<220>
<221>  misc_feature
<222>  (20)..(22)
<223>  linked via phosphorothioate

<220>  
<221>  modified_base
<222>  (20)..(20)
<223>  2'-O-methyl modified

<220>  
<221>  modified_base
<222>  (21)..(21)
<223>  2'-O-methyl modified

<220>  
<221>  modified_base
<222>  (22)..(22)
<223>  2'-O-methyl modified

<400>  1085
ugcauccgug ggaacaucag gg                                                22


<210>  1086
<211>  22
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  Modified antisense strand


<220>
<221>  misc_feature
<222>  (1)..(3)
<223>  linked via phosphorothioate

<220>  
<221>  modified_base
<222>  (1)..(1)
<223>  5'-methoxyphosphonate-4-oxy modified

<220>  
<221>  modified_base
<222>  (2)..(2)
<223>  2'-fluoro modified

<220>  
<221>  modified_base
<222>  (3)..(3)
<223>  2'-fluoro modified

<220>  
<221>  modified_base
<222>  (4)..(4)
<223>  2'-O-methyl modified

<220>  
<221>  modified_base
<222>  (5)..(5)
<223>  2'-fluoro modified

<220>  
<221>  modified_base
<222>  (6)..(6)
<223>  2'-O-methyl modified

<220>  
<221>  modified_base
<222>  (7)..(7)
<223>  2'-fluoro modified

<220>  
<221>  modified_base
<222>  (8)..(8)
<223>  2'-O-methyl modified

<220>  
<221>  modified_base
<222>  (9)..(9)
<223>  2'-O-methyl modified

<220>  
<221>  modified_base
<222>  (10)..(10)
<223>  2'-fluoro modified

<220>  
<221>  modified_base
<222>  (11)..(11)
<223>  2'-O-methyl modified

<220>  
<221>  modified_base
<222>  (12)..(12)
<223>  2'-O-methyl modified

<220>  
<221>  modified_base
<222>  (13)..(13)
<223>  2'-O-methyl modified

<220>  
<221>  modified_base
<222>  (14)..(14)
<223>  2'-fluoro modified

<220>  
<221>  modified_base
<222>  (15)..(15)
<223>  2'-O-methyl modified

<220>  
<221>  modified_base
<222>  (16)..(16)
<223>  2'-O-methyl modified

<220>  
<221>  modified_base
<222>  (17)..(17)
<223>  2'-O-methyl modified

<220>  
<221>  modified_base
<222>  (18)..(18)
<223>  2'-O-methyl modified

<220>  
<221>  modified_base
<222>  (19)..(19)
<223>  2'-O-methyl modified

<220>
<221>  misc_feature
<222>  (20)..(22)
<223>  linked via phosphorothioate

<220>  
<221>  modified_base
<222>  (20)..(20)
<223>  2'-O-methyl modified

<220>  
<221>  modified_base
<222>  (21)..(21)
<223>  2'-O-methyl modified

<220>  
<221>  modified_base
<222>  (22)..(22)
<223>  2'-O-methyl modified

<400>  1086
uuagcauccg ugggaacauc gg                                                22


<210>  1087
<211>  22
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  Modified antisense strand


<220>
<221>  misc_feature
<222>  (1)..(4)
<223>  linked via phosphorothioate

<220>  
<221>  modified_base
<222>  (1)..(1)
<223>  5'-methoxyphosphonate-4-oxy modified

<220>  
<221>  modified_base
<222>  (2)..(2)
<223>  2'-fluoro modified

<220>  
<221>  modified_base
<222>  (3)..(3)
<223>  2'-fluoro modified

<220>  
<221>  modified_base
<222>  (4)..(4)
<223>  2'-fluoro modified

<220>  
<221>  modified_base
<222>  (5)..(5)
<223>  2'-fluoro modified

<220>  
<221>  modified_base
<222>  (6)..(6)
<223>  2'-O-methyl modified

<220>  
<221>  modified_base
<222>  (7)..(7)
<223>  2'-fluoro modified

<220>  
<221>  modified_base
<222>  (8)..(8)
<223>  2'-O-methyl modified

<220>  
<221>  modified_base
<222>  (9)..(9)
<223>  2'-O-methyl modified

<220>  
<221>  modified_base
<222>  (10)..(10)
<223>  2'-fluoro modified

<220>  
<221>  modified_base
<222>  (11)..(11)
<223>  2'-O-methyl modified

<220>  
<221>  modified_base
<222>  (12)..(12)
<223>  2'-O-methyl modified

<220>  
<221>  modified_base
<222>  (13)..(13)
<223>  2'-O-methyl modified

<220>  
<221>  modified_base
<222>  (14)..(14)
<223>  2'-fluoro modified

<220>  
<221>  modified_base
<222>  (15)..(15)
<223>  2'-O-methyl modified

<220>  
<221>  modified_base
<222>  (16)..(16)
<223>  2'-O-methyl modified

<220>  
<221>  modified_base
<222>  (17)..(17)
<223>  2'-O-methyl modified

<220>  
<221>  modified_base
<222>  (18)..(18)
<223>  2'-O-methyl modified

<220>  
<221>  modified_base
<222>  (19)..(19)
<223>  2'-O-methyl modified

<220>
<221>  misc_feature
<222>  (20)..(22)
<223>  linked via phosphorothioate

<220>  
<221>  modified_base
<222>  (20)..(20)
<223>  2'-O-methyl modified

<220>  
<221>  modified_base
<222>  (21)..(21)
<223>  2'-O-methyl modified

<220>  
<221>  modified_base
<222>  (22)..(22)
<223>  2'-O-methyl modified

<400>  1087
uuuagcaucc gugggaacau gg                                                22


<210>  1088
<211>  22
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  Modified antisense strand


<220>
<221>  misc_feature
<222>  (1)..(4)
<223>  linked via phosphorothioate

<220>  
<221>  modified_base
<222>  (1)..(1)
<223>  5'-methoxyphosphonate-4-oxy modified

<220>  
<221>  modified_base
<222>  (2)..(2)
<223>  2'-fluoro modified

<220>  
<221>  modified_base
<222>  (3)..(3)
<223>  2'-fluoro modified

<220>  
<221>  modified_base
<222>  (4)..(4)
<223>  2'-fluoro modified

<220>  
<221>  modified_base
<222>  (5)..(5)
<223>  2'-fluoro modified

<220>  
<221>  modified_base
<222>  (6)..(6)
<223>  2'-O-methyl modified

<220>  
<221>  modified_base
<222>  (7)..(7)
<223>  2'-fluoro modified

<220>  
<221>  modified_base
<222>  (8)..(8)
<223>  2'-O-methyl modified

<220>  
<221>  modified_base
<222>  (9)..(9)
<223>  2'-O-methyl modified

<220>  
<221>  modified_base
<222>  (10)..(10)
<223>  2'-fluoro modified

<220>  
<221>  modified_base
<222>  (11)..(11)
<223>  2'-O-methyl modified

<220>  
<221>  modified_base
<222>  (12)..(12)
<223>  2'-O-methyl modified

<220>  
<221>  modified_base
<222>  (13)..(13)
<223>  2'-O-methyl modified

<220>  
<221>  modified_base
<222>  (14)..(14)
<223>  2'-fluoro modified

<220>  
<221>  modified_base
<222>  (15)..(15)
<223>  2'-O-methyl modified

<220>  
<221>  modified_base
<222>  (16)..(16)
<223>  2'-O-methyl modified

<220>  
<221>  modified_base
<222>  (17)..(17)
<223>  2'-O-methyl modified

<220>  
<221>  modified_base
<222>  (18)..(18)
<223>  2'-O-methyl modified

<220>  
<221>  modified_base
<222>  (19)..(19)
<223>  2'-O-methyl modified

<220>
<221>  misc_feature
<222>  (20)..(22)
<223>  linked via phosphorothioate

<220>  
<221>  modified_base
<222>  (20)..(20)
<223>  2'-O-methyl modified

<220>  
<221>  modified_base
<222>  (21)..(21)
<223>  2'-O-methyl modified

<220>  
<221>  modified_base
<222>  (22)..(22)
<223>  2'-O-methyl modified

<400>  1088
uuuucauuag cauccguggg gg                                                22


<210>  1089
<211>  22
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  Modified antisense strand


<220>
<221>  misc_feature
<222>  (1)..(4)
<223>  linked via phosphorothioate

<220>  
<221>  modified_base
<222>  (1)..(1)
<223>  5'-methoxyphosphonate-4-oxy modified

<220>  
<221>  modified_base
<222>  (2)..(2)
<223>  2'-fluoro modified

<220>  
<221>  modified_base
<222>  (3)..(3)
<223>  2'-fluoro modified

<220>  
<221>  modified_base
<222>  (4)..(4)
<223>  2'-fluoro modified

<220>  
<221>  modified_base
<222>  (5)..(5)
<223>  2'-fluoro modified

<220>  
<221>  modified_base
<222>  (6)..(6)
<223>  2'-O-methyl modified

<220>  
<221>  modified_base
<222>  (7)..(7)
<223>  2'-fluoro modified

<220>  
<221>  modified_base
<222>  (8)..(8)
<223>  2'-O-methyl modified

<220>  
<221>  modified_base
<222>  (9)..(9)
<223>  2'-O-methyl modified

<220>  
<221>  modified_base
<222>  (10)..(10)
<223>  2'-fluoro modified

<220>  
<221>  modified_base
<222>  (11)..(11)
<223>  2'-O-methyl modified

<220>  
<221>  modified_base
<222>  (12)..(12)
<223>  2'-O-methyl modified

<220>  
<221>  modified_base
<222>  (13)..(13)
<223>  2'-O-methyl modified

<220>  
<221>  modified_base
<222>  (14)..(14)
<223>  2'-fluoro modified

<220>  
<221>  modified_base
<222>  (15)..(15)
<223>  2'-O-methyl modified

<220>  
<221>  modified_base
<222>  (16)..(16)
<223>  2'-O-methyl modified

<220>  
<221>  modified_base
<222>  (17)..(17)
<223>  2'-O-methyl modified

<220>  
<221>  modified_base
<222>  (18)..(18)
<223>  2'-O-methyl modified

<220>  
<221>  modified_base
<222>  (19)..(19)
<223>  2'-O-methyl modified

<220>
<221>  misc_feature
<222>  (20)..(22)
<223>  linked via phosphorothioate

<220>  
<221>  modified_base
<222>  (20)..(20)
<223>  2'-O-methyl modified

<220>  
<221>  modified_base
<222>  (21)..(21)
<223>  2'-O-methyl modified

<220>  
<221>  modified_base
<222>  (22)..(22)
<223>  2'-O-methyl modified

<400>  1089
uccaguuuca uuagcauccg gg                                                22


<210>  1090
<211>  22
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  Modified antisense strand


<220>
<221>  misc_feature
<222>  (1)..(4)
<223>  linked via phosphorothioate

<220>  
<221>  modified_base
<222>  (1)..(1)
<223>  5'-methoxyphosphonate-4-oxy modified

<220>  
<221>  modified_base
<222>  (2)..(2)
<223>  2'-fluoro modified

<220>  
<221>  modified_base
<222>  (3)..(3)
<223>  2'-fluoro modified

<220>  
<221>  modified_base
<222>  (4)..(4)
<223>  2'-fluoro modified

<220>  
<221>  modified_base
<222>  (5)..(5)
<223>  2'-fluoro modified

<220>  
<221>  modified_base
<222>  (6)..(6)
<223>  2'-O-methyl modified

<220>  
<221>  modified_base
<222>  (7)..(7)
<223>  2'-fluoro modified

<220>  
<221>  modified_base
<222>  (8)..(8)
<223>  2'-O-methyl modified

<220>  
<221>  modified_base
<222>  (9)..(9)
<223>  2'-O-methyl modified

<220>  
<221>  modified_base
<222>  (10)..(10)
<223>  2'-fluoro modified

<220>  
<221>  modified_base
<222>  (11)..(11)
<223>  2'-O-methyl modified

<220>  
<221>  modified_base
<222>  (12)..(12)
<223>  2'-O-methyl modified

<220>  
<221>  modified_base
<222>  (13)..(13)
<223>  2'-O-methyl modified

<220>  
<221>  modified_base
<222>  (14)..(14)
<223>  2'-fluoro modified

<220>  
<221>  modified_base
<222>  (15)..(15)
<223>  2'-O-methyl modified

<220>  
<221>  modified_base
<222>  (16)..(16)
<223>  2'-O-methyl modified

<220>  
<221>  modified_base
<222>  (17)..(17)
<223>  2'-O-methyl modified

<220>  
<221>  modified_base
<222>  (18)..(18)
<223>  2'-O-methyl modified

<220>  
<221>  modified_base
<222>  (19)..(19)
<223>  2'-O-methyl modified

<220>
<221>  misc_feature
<222>  (20)..(22)
<223>  linked via phosphorothioate

<220>  
<221>  modified_base
<222>  (20)..(20)
<223>  2'-O-methyl modified

<220>  
<221>  modified_base
<222>  (21)..(21)
<223>  2'-O-methyl modified

<220>  
<221>  modified_base
<222>  (22)..(22)
<223>  2'-O-methyl modified

<400>  1090
uaccaguuuc auuagcaucc gg                                                22


<210>  1091
<211>  22
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  Modified antisense strand


<220>
<221>  misc_feature
<222>  (1)..(4)
<223>  linked via phosphorothioate

<220>  
<221>  modified_base
<222>  (1)..(1)
<223>  5'-methoxyphosphonate-4-oxy modified

<220>  
<221>  modified_base
<222>  (2)..(2)
<223>  2'-fluoro modified

<220>  
<221>  modified_base
<222>  (3)..(3)
<223>  2'-fluoro modified

<220>  
<221>  modified_base
<222>  (4)..(4)
<223>  2'-fluoro modified

<220>  
<221>  modified_base
<222>  (5)..(5)
<223>  2'-fluoro modified

<220>  
<221>  modified_base
<222>  (6)..(6)
<223>  2'-O-methyl modified

<220>  
<221>  modified_base
<222>  (7)..(7)
<223>  2'-fluoro modified

<220>  
<221>  modified_base
<222>  (8)..(8)
<223>  2'-O-methyl modified

<220>  
<221>  modified_base
<222>  (9)..(9)
<223>  2'-O-methyl modified

<220>  
<221>  modified_base
<222>  (10)..(10)
<223>  2'-fluoro modified

<220>  
<221>  modified_base
<222>  (11)..(11)
<223>  2'-O-methyl modified

<220>  
<221>  modified_base
<222>  (12)..(12)
<223>  2'-O-methyl modified

<220>  
<221>  modified_base
<222>  (13)..(13)
<223>  2'-O-methyl modified

<220>  
<221>  modified_base
<222>  (14)..(14)
<223>  2'-fluoro modified

<220>  
<221>  modified_base
<222>  (15)..(15)
<223>  2'-O-methyl modified

<220>  
<221>  modified_base
<222>  (16)..(16)
<223>  2'-O-methyl modified

<220>  
<221>  modified_base
<222>  (17)..(17)
<223>  2'-O-methyl modified

<220>  
<221>  modified_base
<222>  (18)..(18)
<223>  2'-O-methyl modified

<220>  
<221>  modified_base
<222>  (19)..(19)
<223>  2'-O-methyl modified

<220>
<221>  misc_feature
<222>  (20)..(22)
<223>  linked via phosphorothioate

<220>  
<221>  modified_base
<222>  (20)..(20)
<223>  2'-O-methyl modified

<220>  
<221>  modified_base
<222>  (21)..(21)
<223>  2'-O-methyl modified

<220>  
<221>  modified_base
<222>  (22)..(22)
<223>  2'-O-methyl modified

<400>  1091
ucaccaguuu cauuagcauc gg                                                22


<210>  1092
<211>  22
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  Modified antisense strand


<220>
<221>  misc_feature
<222>  (1)..(4)
<223>  linked via phosphorothioate

<220>  
<221>  modified_base
<222>  (1)..(1)
<223>  5'-methoxyphosphonate-4-oxy modified

<220>  
<221>  modified_base
<222>  (2)..(2)
<223>  2'-fluoro modified

<220>  
<221>  modified_base
<222>  (3)..(3)
<223>  2'-fluoro modified

<220>  
<221>  modified_base
<222>  (4)..(4)
<223>  2'-fluoro modified

<220>  
<221>  modified_base
<222>  (5)..(5)
<223>  2'-fluoro modified

<220>  
<221>  modified_base
<222>  (6)..(6)
<223>  2'-O-methyl modified

<220>  
<221>  modified_base
<222>  (7)..(7)
<223>  2'-fluoro modified

<220>  
<221>  modified_base
<222>  (8)..(8)
<223>  2'-O-methyl modified

<220>  
<221>  modified_base
<222>  (9)..(9)
<223>  2'-O-methyl modified

<220>  
<221>  modified_base
<222>  (10)..(10)
<223>  2'-fluoro modified

<220>  
<221>  modified_base
<222>  (11)..(11)
<223>  2'-O-methyl modified

<220>  
<221>  modified_base
<222>  (12)..(12)
<223>  2'-O-methyl modified

<220>  
<221>  modified_base
<222>  (13)..(13)
<223>  2'-O-methyl modified

<220>  
<221>  modified_base
<222>  (14)..(14)
<223>  2'-fluoro modified

<220>  
<221>  modified_base
<222>  (15)..(15)
<223>  2'-O-methyl modified

<220>  
<221>  modified_base
<222>  (16)..(16)
<223>  2'-O-methyl modified

<220>  
<221>  modified_base
<222>  (17)..(17)
<223>  2'-O-methyl modified

<220>  
<221>  modified_base
<222>  (18)..(18)
<223>  2'-O-methyl modified

<220>  
<221>  modified_base
<222>  (19)..(19)
<223>  2'-O-methyl modified

<220>
<221>  misc_feature
<222>  (20)..(22)
<223>  linked via phosphorothioate

<220>  
<221>  modified_base
<222>  (20)..(20)
<223>  2'-O-methyl modified

<220>  
<221>  modified_base
<222>  (21)..(21)
<223>  2'-O-methyl modified

<220>  
<221>  modified_base
<222>  (22)..(22)
<223>  2'-O-methyl modified

<400>  1092
uucaccaguu ucauuagcau gg                                                22


<210>  1093
<211>  22
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  Modified antisense strand


<220>
<221>  misc_feature
<222>  (1)..(4)
<223>  linked via phosphorothioate

<220>  
<221>  modified_base
<222>  (1)..(1)
<223>  5'-methoxyphosphonate-4-oxy modified

<220>  
<221>  modified_base
<222>  (2)..(2)
<223>  2'-fluoro modified

<220>  
<221>  modified_base
<222>  (3)..(3)
<223>  2'-fluoro modified

<220>  
<221>  modified_base
<222>  (4)..(4)
<223>  2'-fluoro modified

<220>  
<221>  modified_base
<222>  (5)..(5)
<223>  2'-fluoro modified

<220>  
<221>  modified_base
<222>  (6)..(6)
<223>  2'-O-methyl modified

<220>  
<221>  modified_base
<222>  (7)..(7)
<223>  2'-fluoro modified

<220>  
<221>  modified_base
<222>  (8)..(8)
<223>  2'-O-methyl modified

<220>  
<221>  modified_base
<222>  (9)..(9)
<223>  2'-O-methyl modified

<220>  
<221>  modified_base
<222>  (10)..(10)
<223>  2'-fluoro modified

<220>  
<221>  modified_base
<222>  (11)..(11)
<223>  2'-O-methyl modified

<220>  
<221>  modified_base
<222>  (12)..(12)
<223>  2'-O-methyl modified

<220>  
<221>  modified_base
<222>  (13)..(13)
<223>  2'-O-methyl modified

<220>  
<221>  modified_base
<222>  (14)..(14)
<223>  2'-fluoro modified

<220>  
<221>  modified_base
<222>  (15)..(15)
<223>  2'-O-methyl modified

<220>  
<221>  modified_base
<222>  (16)..(16)
<223>  2'-O-methyl modified

<220>  
<221>  modified_base
<222>  (17)..(17)
<223>  2'-O-methyl modified

<220>  
<221>  modified_base
<222>  (18)..(18)
<223>  2'-O-methyl modified

<220>  
<221>  modified_base
<222>  (19)..(19)
<223>  2'-O-methyl modified

<220>
<221>  misc_feature
<222>  (20)..(22)
<223>  linked via phosphorothioate

<220>  
<221>  modified_base
<222>  (20)..(20)
<223>  2'-O-methyl modified

<220>  
<221>  modified_base
<222>  (21)..(21)
<223>  2'-O-methyl modified

<220>  
<221>  modified_base
<222>  (22)..(22)
<223>  2'-O-methyl modified

<400>  1093
uggcucacca guuucauuag gg                                                22


<210>  1094
<211>  22
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  Modified antisense strand


<220>
<221>  misc_feature
<222>  (1)..(4)
<223>  linked via phosphorothioate

<220>  
<221>  modified_base
<222>  (1)..(1)
<223>  5'-methoxyphosphonate-4-oxy modified

<220>  
<221>  modified_base
<222>  (2)..(2)
<223>  2'-fluoro modified

<220>  
<221>  modified_base
<222>  (3)..(3)
<223>  2'-fluoro modified

<220>  
<221>  modified_base
<222>  (4)..(4)
<223>  2'-fluoro modified

<220>  
<221>  modified_base
<222>  (5)..(5)
<223>  2'-fluoro modified

<220>  
<221>  modified_base
<222>  (6)..(6)
<223>  2'-O-methyl modified

<220>  
<221>  modified_base
<222>  (7)..(7)
<223>  2'-fluoro modified

<220>  
<221>  modified_base
<222>  (8)..(8)
<223>  2'-O-methyl modified

<220>  
<221>  modified_base
<222>  (9)..(9)
<223>  2'-O-methyl modified

<220>  
<221>  modified_base
<222>  (10)..(10)
<223>  2'-fluoro modified

<220>  
<221>  modified_base
<222>  (11)..(11)
<223>  2'-O-methyl modified

<220>  
<221>  modified_base
<222>  (12)..(12)
<223>  2'-O-methyl modified

<220>  
<221>  modified_base
<222>  (13)..(13)
<223>  2'-O-methyl modified

<220>  
<221>  modified_base
<222>  (14)..(14)
<223>  2'-fluoro modified

<220>  
<221>  modified_base
<222>  (15)..(15)
<223>  2'-O-methyl modified

<220>  
<221>  modified_base
<222>  (16)..(16)
<223>  2'-O-methyl modified

<220>  
<221>  modified_base
<222>  (17)..(17)
<223>  2'-O-methyl modified

<220>  
<221>  modified_base
<222>  (18)..(18)
<223>  2'-O-methyl modified

<220>  
<221>  modified_base
<222>  (19)..(19)
<223>  2'-O-methyl modified

<220>
<221>  misc_feature
<222>  (20)..(22)
<223>  linked via phosphorothioate

<220>  
<221>  modified_base
<222>  (20)..(20)
<223>  2'-O-methyl modified

<220>  
<221>  modified_base
<222>  (21)..(21)
<223>  2'-O-methyl modified

<220>  
<221>  modified_base
<222>  (22)..(22)
<223>  2'-O-methyl modified

<400>  1094
ugcucugagu ggacgcugcu gg                                                22


<210>  1095
<211>  22
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  Modified antisense strand


<220>
<221>  misc_feature
<222>  (1)..(4)
<223>  linked via phosphorothioate

<220>  
<221>  modified_base
<222>  (1)..(1)
<223>  5'-methoxyphosphonate-4-oxy modified

<220>  
<221>  modified_base
<222>  (2)..(2)
<223>  2'-fluoro modified

<220>  
<221>  modified_base
<222>  (3)..(3)
<223>  2'-fluoro modified

<220>  
<221>  modified_base
<222>  (4)..(4)
<223>  2'-fluoro modified

<220>  
<221>  modified_base
<222>  (5)..(5)
<223>  2'-fluoro modified

<220>  
<221>  modified_base
<222>  (6)..(6)
<223>  2'-O-methyl modified

<220>  
<221>  modified_base
<222>  (7)..(7)
<223>  2'-fluoro modified

<220>  
<221>  modified_base
<222>  (8)..(8)
<223>  2'-O-methyl modified

<220>  
<221>  modified_base
<222>  (9)..(9)
<223>  2'-O-methyl modified

<220>  
<221>  modified_base
<222>  (10)..(10)
<223>  2'-fluoro modified

<220>  
<221>  modified_base
<222>  (11)..(11)
<223>  2'-O-methyl modified

<220>  
<221>  modified_base
<222>  (12)..(12)
<223>  2'-O-methyl modified

<220>  
<221>  modified_base
<222>  (13)..(13)
<223>  2'-O-methyl modified

<220>  
<221>  modified_base
<222>  (14)..(14)
<223>  2'-fluoro modified

<220>  
<221>  modified_base
<222>  (15)..(15)
<223>  2'-O-methyl modified

<220>  
<221>  modified_base
<222>  (16)..(16)
<223>  2'-O-methyl modified

<220>  
<221>  modified_base
<222>  (17)..(17)
<223>  2'-O-methyl modified

<220>  
<221>  modified_base
<222>  (18)..(18)
<223>  2'-O-methyl modified

<220>  
<221>  modified_base
<222>  (19)..(19)
<223>  2'-O-methyl modified

<220>
<221>  misc_feature
<222>  (20)..(22)
<223>  linked via phosphorothioate

<220>  
<221>  modified_base
<222>  (20)..(20)
<223>  2'-O-methyl modified

<220>  
<221>  modified_base
<222>  (21)..(21)
<223>  2'-O-methyl modified

<220>  
<221>  modified_base
<222>  (22)..(22)
<223>  2'-O-methyl modified

<400>  1095
uuugcucuga guggacgcug gg                                                22


<210>  1096
<211>  22
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  Modified antisense strand


<220>
<221>  misc_feature
<222>  (1)..(4)
<223>  linked via phosphorothioate

<220>  
<221>  modified_base
<222>  (1)..(1)
<223>  5'-methoxyphosphonate-4-oxy modified

<220>  
<221>  modified_base
<222>  (2)..(2)
<223>  2'-fluoro modified

<220>  
<221>  modified_base
<222>  (3)..(3)
<223>  2'-fluoro modified

<220>  
<221>  modified_base
<222>  (4)..(4)
<223>  2'-fluoro modified

<220>  
<221>  modified_base
<222>  (5)..(5)
<223>  2'-fluoro modified

<220>  
<221>  modified_base
<222>  (6)..(6)
<223>  2'-O-methyl modified

<220>  
<221>  modified_base
<222>  (7)..(7)
<223>  2'-fluoro modified

<220>  
<221>  modified_base
<222>  (8)..(8)
<223>  2'-O-methyl modified

<220>  
<221>  modified_base
<222>  (9)..(9)
<223>  2'-O-methyl modified

<220>  
<221>  modified_base
<222>  (10)..(10)
<223>  2'-fluoro modified

<220>  
<221>  modified_base
<222>  (11)..(11)
<223>  2'-O-methyl modified

<220>  
<221>  modified_base
<222>  (12)..(12)
<223>  2'-O-methyl modified

<220>  
<221>  modified_base
<222>  (13)..(13)
<223>  2'-O-methyl modified

<220>  
<221>  modified_base
<222>  (14)..(14)
<223>  2'-fluoro modified

<220>  
<221>  modified_base
<222>  (15)..(15)
<223>  2'-O-methyl modified

<220>  
<221>  modified_base
<222>  (16)..(16)
<223>  2'-O-methyl modified

<220>  
<221>  modified_base
<222>  (17)..(17)
<223>  2'-O-methyl modified

<220>  
<221>  modified_base
<222>  (18)..(18)
<223>  2'-O-methyl modified

<220>  
<221>  modified_base
<222>  (19)..(19)
<223>  2'-O-methyl modified

<220>
<221>  misc_feature
<222>  (20)..(22)
<223>  linked via phosphorothioate

<220>  
<221>  modified_base
<222>  (20)..(20)
<223>  2'-O-methyl modified

<220>  
<221>  modified_base
<222>  (21)..(21)
<223>  2'-O-methyl modified

<220>  
<221>  modified_base
<222>  (22)..(22)
<223>  2'-O-methyl modified

<400>  1096
ucuugcucug aguggacgcu gg                                                22


<210>  1097
<211>  22
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  Modified antisense strand


<220>
<221>  misc_feature
<222>  (1)..(4)
<223>  linked via phosphorothioate

<220>  
<221>  modified_base
<222>  (1)..(1)
<223>  5'-methoxyphosphonate-4-oxy modified

<220>  
<221>  modified_base
<222>  (2)..(2)
<223>  2'-fluoro modified

<220>  
<221>  modified_base
<222>  (3)..(3)
<223>  2'-fluoro modified

<220>  
<221>  modified_base
<222>  (4)..(4)
<223>  2'-fluoro modified

<220>  
<221>  modified_base
<222>  (5)..(5)
<223>  2'-fluoro modified

<220>  
<221>  modified_base
<222>  (6)..(6)
<223>  2'-O-methyl modified

<220>  
<221>  modified_base
<222>  (7)..(7)
<223>  2'-fluoro modified

<220>  
<221>  modified_base
<222>  (8)..(8)
<223>  2'-O-methyl modified

<220>  
<221>  modified_base
<222>  (9)..(9)
<223>  2'-O-methyl modified

<220>  
<221>  modified_base
<222>  (10)..(10)
<223>  2'-fluoro modified

<220>  
<221>  modified_base
<222>  (11)..(11)
<223>  2'-O-methyl modified

<220>  
<221>  modified_base
<222>  (12)..(12)
<223>  2'-O-methyl modified

<220>  
<221>  modified_base
<222>  (13)..(13)
<223>  2'-O-methyl modified

<220>  
<221>  modified_base
<222>  (14)..(14)
<223>  2'-fluoro modified

<220>  
<221>  modified_base
<222>  (15)..(15)
<223>  2'-O-methyl modified

<220>  
<221>  modified_base
<222>  (16)..(16)
<223>  2'-O-methyl modified

<220>  
<221>  modified_base
<222>  (17)..(17)
<223>  2'-O-methyl modified

<220>  
<221>  modified_base
<222>  (18)..(18)
<223>  2'-O-methyl modified

<220>  
<221>  modified_base
<222>  (19)..(19)
<223>  2'-O-methyl modified

<220>
<221>  misc_feature
<222>  (20)..(22)
<223>  linked via phosphorothioate

<220>  
<221>  modified_base
<222>  (20)..(20)
<223>  2'-O-methyl modified

<220>  
<221>  modified_base
<222>  (21)..(21)
<223>  2'-O-methyl modified

<220>  
<221>  modified_base
<222>  (22)..(22)
<223>  2'-O-methyl modified

<400>  1097
ucaaacacuu gcucugagug gg                                                22


<210>  1098
<211>  22
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  Modified antisense strand


<220>
<221>  misc_feature
<222>  (1)..(4)
<223>  linked via phosphorothioate

<220>  
<221>  modified_base
<222>  (1)..(1)
<223>  5'-methoxyphosphonate-4-oxy modified

<220>  
<221>  modified_base
<222>  (2)..(2)
<223>  2'-fluoro modified

<220>  
<221>  modified_base
<222>  (3)..(3)
<223>  2'-fluoro modified

<220>  
<221>  modified_base
<222>  (4)..(4)
<223>  2'-fluoro modified

<220>  
<221>  modified_base
<222>  (5)..(5)
<223>  2'-fluoro modified

<220>  
<221>  modified_base
<222>  (6)..(6)
<223>  2'-O-methyl modified

<220>  
<221>  modified_base
<222>  (7)..(7)
<223>  2'-fluoro modified

<220>  
<221>  modified_base
<222>  (8)..(8)
<223>  2'-O-methyl modified

<220>  
<221>  modified_base
<222>  (9)..(9)
<223>  2'-O-methyl modified

<220>  
<221>  modified_base
<222>  (10)..(10)
<223>  2'-fluoro modified

<220>  
<221>  modified_base
<222>  (11)..(11)
<223>  2'-O-methyl modified

<220>  
<221>  modified_base
<222>  (12)..(12)
<223>  2'-O-methyl modified

<220>  
<221>  modified_base
<222>  (13)..(13)
<223>  2'-O-methyl modified

<220>  
<221>  modified_base
<222>  (14)..(14)
<223>  2'-fluoro modified

<220>  
<221>  modified_base
<222>  (15)..(15)
<223>  2'-O-methyl modified

<220>  
<221>  modified_base
<222>  (16)..(16)
<223>  2'-O-methyl modified

<220>  
<221>  modified_base
<222>  (17)..(17)
<223>  2'-O-methyl modified

<220>  
<221>  modified_base
<222>  (18)..(18)
<223>  2'-O-methyl modified

<220>  
<221>  modified_base
<222>  (19)..(19)
<223>  2'-O-methyl modified

<220>
<221>  misc_feature
<222>  (20)..(22)
<223>  linked via phosphorothioate

<220>  
<221>  modified_base
<222>  (20)..(20)
<223>  2'-O-methyl modified

<220>  
<221>  modified_base
<222>  (21)..(21)
<223>  2'-O-methyl modified

<220>  
<221>  modified_base
<222>  (22)..(22)
<223>  2'-O-methyl modified

<400>  1098
ugacgcagug caaacacuug gg                                                22


<210>  1099
<211>  22
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  Modified antisense strand


<220>
<221>  misc_feature
<222>  (1)..(4)
<223>  linked via phosphorothioate

<220>  
<221>  modified_base
<222>  (1)..(1)
<223>  5'-methoxyphosphonate-4-oxy modified

<220>  
<221>  modified_base
<222>  (2)..(2)
<223>  2'-fluoro modified

<220>  
<221>  modified_base
<222>  (3)..(3)
<223>  2'-fluoro modified

<220>  
<221>  modified_base
<222>  (4)..(4)
<223>  2'-fluoro modified

<220>  
<221>  modified_base
<222>  (5)..(5)
<223>  2'-fluoro modified

<220>  
<221>  modified_base
<222>  (6)..(6)
<223>  2'-O-methyl modified

<220>  
<221>  modified_base
<222>  (7)..(7)
<223>  2'-fluoro modified

<220>  
<221>  modified_base
<222>  (8)..(8)
<223>  2'-O-methyl modified

<220>  
<221>  modified_base
<222>  (9)..(9)
<223>  2'-O-methyl modified

<220>  
<221>  modified_base
<222>  (10)..(10)
<223>  2'-fluoro modified

<220>  
<221>  modified_base
<222>  (11)..(11)
<223>  2'-O-methyl modified

<220>  
<221>  modified_base
<222>  (12)..(12)
<223>  2'-O-methyl modified

<220>  
<221>  modified_base
<222>  (13)..(13)
<223>  2'-O-methyl modified

<220>  
<221>  modified_base
<222>  (14)..(14)
<223>  2'-fluoro modified

<220>  
<221>  modified_base
<222>  (15)..(15)
<223>  2'-O-methyl modified

<220>  
<221>  modified_base
<222>  (16)..(16)
<223>  2'-O-methyl modified

<220>  
<221>  modified_base
<222>  (17)..(17)
<223>  2'-O-methyl modified

<220>  
<221>  modified_base
<222>  (18)..(18)
<223>  2'-O-methyl modified

<220>  
<221>  modified_base
<222>  (19)..(19)
<223>  2'-O-methyl modified

<220>
<221>  misc_feature
<222>  (20)..(22)
<223>  linked via phosphorothioate

<220>  
<221>  modified_base
<222>  (20)..(20)
<223>  2'-O-methyl modified

<220>  
<221>  modified_base
<222>  (21)..(21)
<223>  2'-O-methyl modified

<220>  
<221>  modified_base
<222>  (22)..(22)
<223>  2'-O-methyl modified

<400>  1099
ucagacgcag ugcaaacacu gg                                                22


<210>  1100
<211>  22
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  Modified antisense strand


<220>
<221>  misc_feature
<222>  (1)..(4)
<223>  linked via phosphorothioate

<220>  
<221>  modified_base
<222>  (1)..(1)
<223>  5'-methoxyphosphonate-4-oxy modified

<220>  
<221>  modified_base
<222>  (2)..(2)
<223>  2'-fluoro modified

<220>  
<221>  modified_base
<222>  (3)..(3)
<223>  2'-fluoro modified

<220>  
<221>  modified_base
<222>  (4)..(4)
<223>  2'-fluoro modified

<220>  
<221>  modified_base
<222>  (5)..(5)
<223>  2'-fluoro modified

<220>  
<221>  modified_base
<222>  (6)..(6)
<223>  2'-O-methyl modified

<220>  
<221>  modified_base
<222>  (7)..(7)
<223>  2'-fluoro modified

<220>  
<221>  modified_base
<222>  (8)..(8)
<223>  2'-O-methyl modified

<220>  
<221>  modified_base
<222>  (9)..(9)
<223>  2'-O-methyl modified

<220>  
<221>  modified_base
<222>  (10)..(10)
<223>  2'-fluoro modified

<220>  
<221>  modified_base
<222>  (11)..(11)
<223>  2'-O-methyl modified

<220>  
<221>  modified_base
<222>  (12)..(12)
<223>  2'-O-methyl modified

<220>  
<221>  modified_base
<222>  (13)..(13)
<223>  2'-O-methyl modified

<220>  
<221>  modified_base
<222>  (14)..(14)
<223>  2'-fluoro modified

<220>  
<221>  modified_base
<222>  (15)..(15)
<223>  2'-O-methyl modified

<220>  
<221>  modified_base
<222>  (16)..(16)
<223>  2'-O-methyl modified

<220>  
<221>  modified_base
<222>  (17)..(17)
<223>  2'-O-methyl modified

<220>  
<221>  modified_base
<222>  (18)..(18)
<223>  2'-O-methyl modified

<220>  
<221>  modified_base
<222>  (19)..(19)
<223>  2'-O-methyl modified

<220>
<221>  misc_feature
<222>  (20)..(22)
<223>  linked via phosphorothioate

<220>  
<221>  modified_base
<222>  (20)..(20)
<223>  2'-O-methyl modified

<220>  
<221>  modified_base
<222>  (21)..(21)
<223>  2'-O-methyl modified

<220>  
<221>  modified_base
<222>  (22)..(22)
<223>  2'-O-methyl modified

<400>  1100
uuuuuguccu gcagacgcag gg                                                22


<210>  1101
<211>  22
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  Modified antisense strand


<220>
<221>  misc_feature
<222>  (1)..(4)
<223>  linked via phosphorothioate

<220>  
<221>  modified_base
<222>  (1)..(1)
<223>  5'-methoxyphosphonate-4-oxy modified

<220>  
<221>  modified_base
<222>  (2)..(2)
<223>  2'-fluoro modified

<220>  
<221>  modified_base
<222>  (3)..(3)
<223>  2'-fluoro modified

<220>  
<221>  modified_base
<222>  (4)..(4)
<223>  2'-fluoro modified

<220>  
<221>  modified_base
<222>  (5)..(5)
<223>  2'-fluoro modified

<220>  
<221>  modified_base
<222>  (6)..(6)
<223>  2'-O-methyl modified

<220>  
<221>  modified_base
<222>  (7)..(7)
<223>  2'-fluoro modified

<220>  
<221>  modified_base
<222>  (8)..(8)
<223>  2'-O-methyl modified

<220>  
<221>  modified_base
<222>  (9)..(9)
<223>  2'-O-methyl modified

<220>  
<221>  modified_base
<222>  (10)..(10)
<223>  2'-fluoro modified

<220>  
<221>  modified_base
<222>  (11)..(11)
<223>  2'-O-methyl modified

<220>  
<221>  modified_base
<222>  (12)..(12)
<223>  2'-O-methyl modified

<220>  
<221>  modified_base
<222>  (13)..(13)
<223>  2'-O-methyl modified

<220>  
<221>  modified_base
<222>  (14)..(14)
<223>  2'-fluoro modified

<220>  
<221>  modified_base
<222>  (15)..(15)
<223>  2'-O-methyl modified

<220>  
<221>  modified_base
<222>  (16)..(16)
<223>  2'-O-methyl modified

<220>  
<221>  modified_base
<222>  (17)..(17)
<223>  2'-O-methyl modified

<220>  
<221>  modified_base
<222>  (18)..(18)
<223>  2'-O-methyl modified

<220>  
<221>  modified_base
<222>  (19)..(19)
<223>  2'-O-methyl modified

<220>
<221>  misc_feature
<222>  (20)..(22)
<223>  linked via phosphorothioate

<220>  
<221>  modified_base
<222>  (20)..(20)
<223>  2'-O-methyl modified

<220>  
<221>  modified_base
<222>  (21)..(21)
<223>  2'-O-methyl modified

<220>  
<221>  modified_base
<222>  (22)..(22)
<223>  2'-O-methyl modified

<400>  1101
ugugggagcu uuuuguccug gg                                                22


<210>  1102
<211>  22
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  Modified antisense strand


<220>
<221>  misc_feature
<222>  (1)..(4)
<223>  linked via phosphorothioate

<220>  
<221>  modified_base
<222>  (1)..(1)
<223>  5'-methoxyphosphonate-4-oxy modified

<220>  
<221>  modified_base
<222>  (2)..(2)
<223>  2'-fluoro modified

<220>  
<221>  modified_base
<222>  (3)..(3)
<223>  2'-fluoro modified

<220>  
<221>  modified_base
<222>  (4)..(4)
<223>  2'-fluoro modified

<220>  
<221>  modified_base
<222>  (5)..(5)
<223>  2'-fluoro modified

<220>  
<221>  modified_base
<222>  (6)..(6)
<223>  2'-O-methyl modified

<220>  
<221>  modified_base
<222>  (7)..(7)
<223>  2'-fluoro modified

<220>  
<221>  modified_base
<222>  (8)..(8)
<223>  2'-O-methyl modified

<220>  
<221>  modified_base
<222>  (9)..(9)
<223>  2'-O-methyl modified

<220>  
<221>  modified_base
<222>  (10)..(10)
<223>  2'-fluoro modified

<220>  
<221>  modified_base
<222>  (11)..(11)
<223>  2'-O-methyl modified

<220>  
<221>  modified_base
<222>  (12)..(12)
<223>  2'-O-methyl modified

<220>  
<221>  modified_base
<222>  (13)..(13)
<223>  2'-O-methyl modified

<220>  
<221>  modified_base
<222>  (14)..(14)
<223>  2'-fluoro modified

<220>  
<221>  modified_base
<222>  (15)..(15)
<223>  2'-O-methyl modified

<220>  
<221>  modified_base
<222>  (16)..(16)
<223>  2'-O-methyl modified

<220>  
<221>  modified_base
<222>  (17)..(17)
<223>  2'-O-methyl modified

<220>  
<221>  modified_base
<222>  (18)..(18)
<223>  2'-O-methyl modified

<220>  
<221>  modified_base
<222>  (19)..(19)
<223>  2'-O-methyl modified

<220>
<221>  misc_feature
<222>  (20)..(22)
<223>  linked via phosphorothioate

<220>  
<221>  modified_base
<222>  (20)..(20)
<223>  2'-O-methyl modified

<220>  
<221>  modified_base
<222>  (21)..(21)
<223>  2'-O-methyl modified

<220>  
<221>  modified_base
<222>  (22)..(22)
<223>  2'-O-methyl modified

<400>  1102
ugcacauccc agaucucaga gg                                                22


<210>  1103
<211>  22
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  Modified antisense strand


<220>
<221>  misc_feature
<222>  (1)..(4)
<223>  linked via phosphorothioate

<220>  
<221>  modified_base
<222>  (1)..(1)
<223>  5'-methoxyphosphonate-4-oxy modified

<220>  
<221>  modified_base
<222>  (2)..(2)
<223>  2'-fluoro modified

<220>  
<221>  modified_base
<222>  (3)..(3)
<223>  2'-fluoro modified

<220>  
<221>  modified_base
<222>  (4)..(4)
<223>  2'-fluoro modified

<220>  
<221>  modified_base
<222>  (5)..(5)
<223>  2'-fluoro modified

<220>  
<221>  modified_base
<222>  (6)..(6)
<223>  2'-O-methyl modified

<220>  
<221>  modified_base
<222>  (7)..(7)
<223>  2'-fluoro modified

<220>  
<221>  modified_base
<222>  (8)..(8)
<223>  2'-O-methyl modified

<220>  
<221>  modified_base
<222>  (9)..(9)
<223>  2'-O-methyl modified

<220>  
<221>  modified_base
<222>  (10)..(10)
<223>  2'-fluoro modified

<220>  
<221>  modified_base
<222>  (11)..(11)
<223>  2'-O-methyl modified

<220>  
<221>  modified_base
<222>  (12)..(12)
<223>  2'-O-methyl modified

<220>  
<221>  modified_base
<222>  (13)..(13)
<223>  2'-O-methyl modified

<220>  
<221>  modified_base
<222>  (14)..(14)
<223>  2'-fluoro modified

<220>  
<221>  modified_base
<222>  (15)..(15)
<223>  2'-O-methyl modified

<220>  
<221>  modified_base
<222>  (16)..(16)
<223>  2'-O-methyl modified

<220>  
<221>  modified_base
<222>  (17)..(17)
<223>  2'-O-methyl modified

<220>  
<221>  modified_base
<222>  (18)..(18)
<223>  2'-O-methyl modified

<220>  
<221>  modified_base
<222>  (19)..(19)
<223>  2'-O-methyl modified

<220>
<221>  misc_feature
<222>  (20)..(22)
<223>  linked via phosphorothioate

<220>  
<221>  modified_base
<222>  (20)..(20)
<223>  2'-O-methyl modified

<220>  
<221>  modified_base
<222>  (21)..(21)
<223>  2'-O-methyl modified

<220>  
<221>  modified_base
<222>  (22)..(22)
<223>  2'-O-methyl modified

<400>  1103
uuucgugcac aucccagauc gg                                                22


<210>  1104
<211>  22
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  Modified antisense strand


<220>
<221>  misc_feature
<222>  (1)..(4)
<223>  linked via phosphorothioate

<220>  
<221>  modified_base
<222>  (1)..(1)
<223>  5'-methoxyphosphonate-4-oxy modified

<220>  
<221>  modified_base
<222>  (2)..(2)
<223>  2'-fluoro modified

<220>  
<221>  modified_base
<222>  (3)..(3)
<223>  2'-fluoro modified

<220>  
<221>  modified_base
<222>  (4)..(4)
<223>  2'-fluoro modified

<220>  
<221>  modified_base
<222>  (5)..(5)
<223>  2'-fluoro modified

<220>  
<221>  modified_base
<222>  (6)..(6)
<223>  2'-O-methyl modified

<220>  
<221>  modified_base
<222>  (7)..(7)
<223>  2'-fluoro modified

<220>  
<221>  modified_base
<222>  (8)..(8)
<223>  2'-O-methyl modified

<220>  
<221>  modified_base
<222>  (9)..(9)
<223>  2'-O-methyl modified

<220>  
<221>  modified_base
<222>  (10)..(10)
<223>  2'-fluoro modified

<220>  
<221>  modified_base
<222>  (11)..(11)
<223>  2'-O-methyl modified

<220>  
<221>  modified_base
<222>  (12)..(12)
<223>  2'-O-methyl modified

<220>  
<221>  modified_base
<222>  (13)..(13)
<223>  2'-O-methyl modified

<220>  
<221>  modified_base
<222>  (14)..(14)
<223>  2'-fluoro modified

<220>  
<221>  modified_base
<222>  (15)..(15)
<223>  2'-O-methyl modified

<220>  
<221>  modified_base
<222>  (16)..(16)
<223>  2'-O-methyl modified

<220>  
<221>  modified_base
<222>  (17)..(17)
<223>  2'-O-methyl modified

<220>  
<221>  modified_base
<222>  (18)..(18)
<223>  2'-O-methyl modified

<220>  
<221>  modified_base
<222>  (19)..(19)
<223>  2'-O-methyl modified

<220>
<221>  misc_feature
<222>  (20)..(22)
<223>  linked via phosphorothioate

<220>  
<221>  modified_base
<222>  (20)..(20)
<223>  2'-O-methyl modified

<220>  
<221>  modified_base
<222>  (21)..(21)
<223>  2'-O-methyl modified

<220>  
<221>  modified_base
<222>  (22)..(22)
<223>  2'-O-methyl modified

<400>  1104
uauucgugca caucccagau gg                                                22


<210>  1105
<211>  22
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  Modified antisense strand


<220>
<221>  misc_feature
<222>  (1)..(4)
<223>  linked via phosphorothioate

<220>  
<221>  modified_base
<222>  (1)..(1)
<223>  5'-methoxyphosphonate-4-oxy modified

<220>  
<221>  modified_base
<222>  (2)..(2)
<223>  2'-fluoro modified

<220>  
<221>  modified_base
<222>  (3)..(3)
<223>  2'-fluoro modified

<220>  
<221>  modified_base
<222>  (4)..(4)
<223>  2'-fluoro modified

<220>  
<221>  modified_base
<222>  (5)..(5)
<223>  2'-fluoro modified

<220>  
<221>  modified_base
<222>  (6)..(6)
<223>  2'-O-methyl modified

<220>  
<221>  modified_base
<222>  (7)..(7)
<223>  2'-fluoro modified

<220>  
<221>  modified_base
<222>  (8)..(8)
<223>  2'-O-methyl modified

<220>  
<221>  modified_base
<222>  (9)..(9)
<223>  2'-O-methyl modified

<220>  
<221>  modified_base
<222>  (10)..(10)
<223>  2'-fluoro modified

<220>  
<221>  modified_base
<222>  (11)..(11)
<223>  2'-O-methyl modified

<220>  
<221>  modified_base
<222>  (12)..(12)
<223>  2'-O-methyl modified

<220>  
<221>  modified_base
<222>  (13)..(13)
<223>  2'-O-methyl modified

<220>  
<221>  modified_base
<222>  (14)..(14)
<223>  2'-fluoro modified

<220>  
<221>  modified_base
<222>  (15)..(15)
<223>  2'-O-methyl modified

<220>  
<221>  modified_base
<222>  (16)..(16)
<223>  2'-O-methyl modified

<220>  
<221>  modified_base
<222>  (17)..(17)
<223>  2'-O-methyl modified

<220>  
<221>  modified_base
<222>  (18)..(18)
<223>  2'-O-methyl modified

<220>  
<221>  modified_base
<222>  (19)..(19)
<223>  2'-O-methyl modified

<220>
<221>  misc_feature
<222>  (20)..(22)
<223>  linked via phosphorothioate

<220>  
<221>  modified_base
<222>  (20)..(20)
<223>  2'-O-methyl modified

<220>  
<221>  modified_base
<222>  (21)..(21)
<223>  2'-O-methyl modified

<220>  
<221>  modified_base
<222>  (22)..(22)
<223>  2'-O-methyl modified

<400>  1105
ucauucgugc acaucccaga gg                                                22


<210>  1106
<211>  22
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  Modified antisense strand


<220>
<221>  misc_feature
<222>  (1)..(4)
<223>  linked via phosphorothioate

<220>  
<221>  modified_base
<222>  (1)..(1)
<223>  5'-methoxyphosphonate-4-oxy modified

<220>  
<221>  modified_base
<222>  (2)..(2)
<223>  2'-fluoro modified

<220>  
<221>  modified_base
<222>  (3)..(3)
<223>  2'-fluoro modified

<220>  
<221>  modified_base
<222>  (4)..(4)
<223>  2'-fluoro modified

<220>  
<221>  modified_base
<222>  (5)..(5)
<223>  2'-fluoro modified

<220>  
<221>  modified_base
<222>  (6)..(6)
<223>  2'-O-methyl modified

<220>  
<221>  modified_base
<222>  (7)..(7)
<223>  2'-fluoro modified

<220>  
<221>  modified_base
<222>  (8)..(8)
<223>  2'-O-methyl modified

<220>  
<221>  modified_base
<222>  (9)..(9)
<223>  2'-O-methyl modified

<220>  
<221>  modified_base
<222>  (10)..(10)
<223>  2'-fluoro modified

<220>  
<221>  modified_base
<222>  (11)..(11)
<223>  2'-O-methyl modified

<220>  
<221>  modified_base
<222>  (12)..(12)
<223>  2'-O-methyl modified

<220>  
<221>  modified_base
<222>  (13)..(13)
<223>  2'-O-methyl modified

<220>  
<221>  modified_base
<222>  (14)..(14)
<223>  2'-fluoro modified

<220>  
<221>  modified_base
<222>  (15)..(15)
<223>  2'-O-methyl modified

<220>  
<221>  modified_base
<222>  (16)..(16)
<223>  2'-O-methyl modified

<220>  
<221>  modified_base
<222>  (17)..(17)
<223>  2'-O-methyl modified

<220>  
<221>  modified_base
<222>  (18)..(18)
<223>  2'-O-methyl modified

<220>  
<221>  modified_base
<222>  (19)..(19)
<223>  2'-O-methyl modified

<220>
<221>  misc_feature
<222>  (20)..(22)
<223>  linked via phosphorothioate

<220>  
<221>  modified_base
<222>  (20)..(20)
<223>  2'-O-methyl modified

<220>  
<221>  modified_base
<222>  (21)..(21)
<223>  2'-O-methyl modified

<220>  
<221>  modified_base
<222>  (22)..(22)
<223>  2'-O-methyl modified

<400>  1106
uaacagucau ucgugcacau gg                                                22


<210>  1107
<211>  22
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  Modified antisense strand


<220>
<221>  misc_feature
<222>  (1)..(4)
<223>  linked via phosphorothioate

<220>  
<221>  modified_base
<222>  (1)..(1)
<223>  5'-methoxyphosphonate-4-oxy modified

<220>  
<221>  modified_base
<222>  (2)..(2)
<223>  2'-fluoro modified

<220>  
<221>  modified_base
<222>  (3)..(3)
<223>  2'-fluoro modified

<220>  
<221>  modified_base
<222>  (4)..(4)
<223>  2'-fluoro modified

<220>  
<221>  modified_base
<222>  (5)..(5)
<223>  2'-fluoro modified

<220>  
<221>  modified_base
<222>  (6)..(6)
<223>  2'-O-methyl modified

<220>  
<221>  modified_base
<222>  (7)..(7)
<223>  2'-fluoro modified

<220>  
<221>  modified_base
<222>  (8)..(8)
<223>  2'-O-methyl modified

<220>  
<221>  modified_base
<222>  (9)..(9)
<223>  2'-O-methyl modified

<220>  
<221>  modified_base
<222>  (10)..(10)
<223>  2'-fluoro modified

<220>  
<221>  modified_base
<222>  (11)..(11)
<223>  2'-O-methyl modified

<220>  
<221>  modified_base
<222>  (12)..(12)
<223>  2'-O-methyl modified

<220>  
<221>  modified_base
<222>  (13)..(13)
<223>  2'-O-methyl modified

<220>  
<221>  modified_base
<222>  (14)..(14)
<223>  2'-fluoro modified

<220>  
<221>  modified_base
<222>  (15)..(15)
<223>  2'-O-methyl modified

<220>  
<221>  modified_base
<222>  (16)..(16)
<223>  2'-O-methyl modified

<220>  
<221>  modified_base
<222>  (17)..(17)
<223>  2'-O-methyl modified

<220>  
<221>  modified_base
<222>  (18)..(18)
<223>  2'-O-methyl modified

<220>  
<221>  modified_base
<222>  (19)..(19)
<223>  2'-O-methyl modified

<220>
<221>  misc_feature
<222>  (20)..(22)
<223>  linked via phosphorothioate

<220>  
<221>  modified_base
<222>  (20)..(20)
<223>  2'-O-methyl modified

<220>  
<221>  modified_base
<222>  (21)..(21)
<223>  2'-O-methyl modified

<220>  
<221>  modified_base
<222>  (22)..(22)
<223>  2'-O-methyl modified

<400>  1107
ugaacaguca uucgugcaca gg                                                22


<210>  1108
<211>  22
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  Modified antisense strand


<220>
<221>  misc_feature
<222>  (1)..(4)
<223>  linked via phosphorothioate

<220>  
<221>  modified_base
<222>  (1)..(1)
<223>  5'-methoxyphosphonate-4-oxy modified

<220>  
<221>  modified_base
<222>  (2)..(2)
<223>  2'-fluoro modified

<220>  
<221>  modified_base
<222>  (3)..(3)
<223>  2'-fluoro modified

<220>  
<221>  modified_base
<222>  (4)..(4)
<223>  2'-fluoro modified

<220>  
<221>  modified_base
<222>  (5)..(5)
<223>  2'-fluoro modified

<220>  
<221>  modified_base
<222>  (6)..(6)
<223>  2'-O-methyl modified

<220>  
<221>  modified_base
<222>  (7)..(7)
<223>  2'-fluoro modified

<220>  
<221>  modified_base
<222>  (8)..(8)
<223>  2'-O-methyl modified

<220>  
<221>  modified_base
<222>  (9)..(9)
<223>  2'-O-methyl modified

<220>  
<221>  modified_base
<222>  (10)..(10)
<223>  2'-fluoro modified

<220>  
<221>  modified_base
<222>  (11)..(11)
<223>  2'-O-methyl modified

<220>  
<221>  modified_base
<222>  (12)..(12)
<223>  2'-O-methyl modified

<220>  
<221>  modified_base
<222>  (13)..(13)
<223>  2'-O-methyl modified

<220>  
<221>  modified_base
<222>  (14)..(14)
<223>  2'-fluoro modified

<220>  
<221>  modified_base
<222>  (15)..(15)
<223>  2'-O-methyl modified

<220>  
<221>  modified_base
<222>  (16)..(16)
<223>  2'-O-methyl modified

<220>  
<221>  modified_base
<222>  (17)..(17)
<223>  2'-O-methyl modified

<220>  
<221>  modified_base
<222>  (18)..(18)
<223>  2'-O-methyl modified

<220>  
<221>  modified_base
<222>  (19)..(19)
<223>  2'-O-methyl modified

<220>
<221>  misc_feature
<222>  (20)..(22)
<223>  linked via phosphorothioate

<220>  
<221>  modified_base
<222>  (20)..(20)
<223>  2'-O-methyl modified

<220>  
<221>  modified_base
<222>  (21)..(21)
<223>  2'-O-methyl modified

<220>  
<221>  modified_base
<222>  (22)..(22)
<223>  2'-O-methyl modified

<400>  1108
uagaacaguc auucgugcac gg                                                22


<210>  1109
<211>  22
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  Modified antisense strand


<220>
<221>  misc_feature
<222>  (1)..(4)
<223>  linked via phosphorothioate

<220>  
<221>  modified_base
<222>  (1)..(1)
<223>  5'-methoxyphosphonate-4-oxy modified

<220>  
<221>  modified_base
<222>  (2)..(2)
<223>  2'-fluoro modified

<220>  
<221>  modified_base
<222>  (3)..(3)
<223>  2'-fluoro modified

<220>  
<221>  modified_base
<222>  (4)..(4)
<223>  2'-fluoro modified

<220>  
<221>  modified_base
<222>  (5)..(5)
<223>  2'-fluoro modified

<220>  
<221>  modified_base
<222>  (6)..(6)
<223>  2'-O-methyl modified

<220>  
<221>  modified_base
<222>  (7)..(7)
<223>  2'-fluoro modified

<220>  
<221>  modified_base
<222>  (8)..(8)
<223>  2'-O-methyl modified

<220>  
<221>  modified_base
<222>  (9)..(9)
<223>  2'-O-methyl modified

<220>  
<221>  modified_base
<222>  (10)..(10)
<223>  2'-fluoro modified

<220>  
<221>  modified_base
<222>  (11)..(11)
<223>  2'-O-methyl modified

<220>  
<221>  modified_base
<222>  (12)..(12)
<223>  2'-O-methyl modified

<220>  
<221>  modified_base
<222>  (13)..(13)
<223>  2'-O-methyl modified

<220>  
<221>  modified_base
<222>  (14)..(14)
<223>  2'-fluoro modified

<220>  
<221>  modified_base
<222>  (15)..(15)
<223>  2'-O-methyl modified

<220>  
<221>  modified_base
<222>  (16)..(16)
<223>  2'-O-methyl modified

<220>  
<221>  modified_base
<222>  (17)..(17)
<223>  2'-O-methyl modified

<220>  
<221>  modified_base
<222>  (18)..(18)
<223>  2'-O-methyl modified

<220>  
<221>  modified_base
<222>  (19)..(19)
<223>  2'-O-methyl modified

<220>
<221>  misc_feature
<222>  (20)..(22)
<223>  linked via phosphorothioate

<220>  
<221>  modified_base
<222>  (20)..(20)
<223>  2'-O-methyl modified

<220>  
<221>  modified_base
<222>  (21)..(21)
<223>  2'-O-methyl modified

<220>  
<221>  modified_base
<222>  (22)..(22)
<223>  2'-O-methyl modified

<400>  1109
uguuccacuu cuaggaggca gg                                                22


<210>  1110
<211>  22
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  Modified antisense strand


<220>
<221>  misc_feature
<222>  (1)..(4)
<223>  linked via phosphorothioate

<220>  
<221>  modified_base
<222>  (1)..(1)
<223>  5'-methoxyphosphonate-4-oxy modified

<220>  
<221>  modified_base
<222>  (2)..(2)
<223>  2'-fluoro modified

<220>  
<221>  modified_base
<222>  (3)..(3)
<223>  2'-fluoro modified

<220>  
<221>  modified_base
<222>  (4)..(4)
<223>  2'-fluoro modified

<220>  
<221>  modified_base
<222>  (5)..(5)
<223>  2'-fluoro modified

<220>  
<221>  modified_base
<222>  (6)..(6)
<223>  2'-O-methyl modified

<220>  
<221>  modified_base
<222>  (7)..(7)
<223>  2'-fluoro modified

<220>  
<221>  modified_base
<222>  (8)..(8)
<223>  2'-O-methyl modified

<220>  
<221>  modified_base
<222>  (9)..(9)
<223>  2'-O-methyl modified

<220>  
<221>  modified_base
<222>  (10)..(10)
<223>  2'-fluoro modified

<220>  
<221>  modified_base
<222>  (11)..(11)
<223>  2'-O-methyl modified

<220>  
<221>  modified_base
<222>  (12)..(12)
<223>  2'-O-methyl modified

<220>  
<221>  modified_base
<222>  (13)..(13)
<223>  2'-O-methyl modified

<220>  
<221>  modified_base
<222>  (14)..(14)
<223>  2'-fluoro modified

<220>  
<221>  modified_base
<222>  (15)..(15)
<223>  2'-O-methyl modified

<220>  
<221>  modified_base
<222>  (16)..(16)
<223>  2'-O-methyl modified

<220>  
<221>  modified_base
<222>  (17)..(17)
<223>  2'-O-methyl modified

<220>  
<221>  modified_base
<222>  (18)..(18)
<223>  2'-O-methyl modified

<220>  
<221>  modified_base
<222>  (19)..(19)
<223>  2'-O-methyl modified

<220>
<221>  misc_feature
<222>  (20)..(22)
<223>  linked via phosphorothioate

<220>  
<221>  modified_base
<222>  (20)..(20)
<223>  2'-O-methyl modified

<220>  
<221>  modified_base
<222>  (21)..(21)
<223>  2'-O-methyl modified

<220>  
<221>  modified_base
<222>  (22)..(22)
<223>  2'-O-methyl modified

<400>  1110
uucagucugu uccacuucua gg                                                22


<210>  1111
<211>  22
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  Modified antisense strand


<220>
<221>  misc_feature
<222>  (1)..(4)
<223>  linked via phosphorothioate

<220>  
<221>  modified_base
<222>  (1)..(1)
<223>  5'-methoxyphosphonate-4-oxy modified

<220>  
<221>  modified_base
<222>  (2)..(2)
<223>  2'-fluoro modified

<220>  
<221>  modified_base
<222>  (3)..(3)
<223>  2'-fluoro modified

<220>  
<221>  modified_base
<222>  (4)..(4)
<223>  2'-fluoro modified

<220>  
<221>  modified_base
<222>  (5)..(5)
<223>  2'-fluoro modified

<220>  
<221>  modified_base
<222>  (6)..(6)
<223>  2'-O-methyl modified

<220>  
<221>  modified_base
<222>  (7)..(7)
<223>  2'-fluoro modified

<220>  
<221>  modified_base
<222>  (8)..(8)
<223>  2'-O-methyl modified

<220>  
<221>  modified_base
<222>  (9)..(9)
<223>  2'-O-methyl modified

<220>  
<221>  modified_base
<222>  (10)..(10)
<223>  2'-fluoro modified

<220>  
<221>  modified_base
<222>  (11)..(11)
<223>  2'-O-methyl modified

<220>  
<221>  modified_base
<222>  (12)..(12)
<223>  2'-O-methyl modified

<220>  
<221>  modified_base
<222>  (13)..(13)
<223>  2'-O-methyl modified

<220>  
<221>  modified_base
<222>  (14)..(14)
<223>  2'-fluoro modified

<220>  
<221>  modified_base
<222>  (15)..(15)
<223>  2'-O-methyl modified

<220>  
<221>  modified_base
<222>  (16)..(16)
<223>  2'-O-methyl modified

<220>  
<221>  modified_base
<222>  (17)..(17)
<223>  2'-O-methyl modified

<220>  
<221>  modified_base
<222>  (18)..(18)
<223>  2'-O-methyl modified

<220>  
<221>  modified_base
<222>  (19)..(19)
<223>  2'-O-methyl modified

<220>
<221>  misc_feature
<222>  (20)..(22)
<223>  linked via phosphorothioate

<220>  
<221>  modified_base
<222>  (20)..(20)
<223>  2'-O-methyl modified

<220>  
<221>  modified_base
<222>  (21)..(21)
<223>  2'-O-methyl modified

<220>  
<221>  modified_base
<222>  (22)..(22)
<223>  2'-O-methyl modified

<400>  1111
ucucagucug uuccacuucu gg                                                22


<210>  1112
<211>  22
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  Modified antisense strand


<220>
<221>  misc_feature
<222>  (1)..(4)
<223>  linked via phosphorothioate

<220>  
<221>  modified_base
<222>  (1)..(1)
<223>  5'-methoxyphosphonate-4-oxy modified

<220>  
<221>  modified_base
<222>  (2)..(2)
<223>  2'-fluoro modified

<220>  
<221>  modified_base
<222>  (3)..(3)
<223>  2'-fluoro modified

<220>  
<221>  modified_base
<222>  (4)..(4)
<223>  2'-fluoro modified

<220>  
<221>  modified_base
<222>  (5)..(5)
<223>  2'-fluoro modified

<220>  
<221>  modified_base
<222>  (6)..(6)
<223>  2'-O-methyl modified

<220>  
<221>  modified_base
<222>  (7)..(7)
<223>  2'-fluoro modified

<220>  
<221>  modified_base
<222>  (8)..(8)
<223>  2'-O-methyl modified

<220>  
<221>  modified_base
<222>  (9)..(9)
<223>  2'-O-methyl modified

<220>  
<221>  modified_base
<222>  (10)..(10)
<223>  2'-fluoro modified

<220>  
<221>  modified_base
<222>  (11)..(11)
<223>  2'-O-methyl modified

<220>  
<221>  modified_base
<222>  (12)..(12)
<223>  2'-O-methyl modified

<220>  
<221>  modified_base
<222>  (13)..(13)
<223>  2'-O-methyl modified

<220>  
<221>  modified_base
<222>  (14)..(14)
<223>  2'-fluoro modified

<220>  
<221>  modified_base
<222>  (15)..(15)
<223>  2'-O-methyl modified

<220>  
<221>  modified_base
<222>  (16)..(16)
<223>  2'-O-methyl modified

<220>  
<221>  modified_base
<222>  (17)..(17)
<223>  2'-O-methyl modified

<220>  
<221>  modified_base
<222>  (18)..(18)
<223>  2'-O-methyl modified

<220>  
<221>  modified_base
<222>  (19)..(19)
<223>  2'-O-methyl modified

<220>
<221>  misc_feature
<222>  (20)..(22)
<223>  linked via phosphorothioate

<220>  
<221>  modified_base
<222>  (20)..(20)
<223>  2'-O-methyl modified

<220>  
<221>  modified_base
<222>  (21)..(21)
<223>  2'-O-methyl modified

<220>  
<221>  modified_base
<222>  (22)..(22)
<223>  2'-O-methyl modified

<400>  1112
uucucagucu guuccacuuc gg                                                22


<210>  1113
<211>  22
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  Modified antisense strand


<220>
<221>  misc_feature
<222>  (1)..(4)
<223>  linked via phosphorothioate

<220>  
<221>  modified_base
<222>  (1)..(1)
<223>  5'-methoxyphosphonate-4-oxy modified

<220>  
<221>  modified_base
<222>  (2)..(2)
<223>  2'-fluoro modified

<220>  
<221>  modified_base
<222>  (3)..(3)
<223>  2'-fluoro modified

<220>  
<221>  modified_base
<222>  (4)..(4)
<223>  2'-fluoro modified

<220>  
<221>  modified_base
<222>  (5)..(5)
<223>  2'-fluoro modified

<220>  
<221>  modified_base
<222>  (6)..(6)
<223>  2'-O-methyl modified

<220>  
<221>  modified_base
<222>  (7)..(7)
<223>  2'-fluoro modified

<220>  
<221>  modified_base
<222>  (8)..(8)
<223>  2'-O-methyl modified

<220>  
<221>  modified_base
<222>  (9)..(9)
<223>  2'-O-methyl modified

<220>  
<221>  modified_base
<222>  (10)..(10)
<223>  2'-fluoro modified

<220>  
<221>  modified_base
<222>  (11)..(11)
<223>  2'-O-methyl modified

<220>  
<221>  modified_base
<222>  (12)..(12)
<223>  2'-O-methyl modified

<220>  
<221>  modified_base
<222>  (13)..(13)
<223>  2'-O-methyl modified

<220>  
<221>  modified_base
<222>  (14)..(14)
<223>  2'-fluoro modified

<220>  
<221>  modified_base
<222>  (15)..(15)
<223>  2'-O-methyl modified

<220>  
<221>  modified_base
<222>  (16)..(16)
<223>  2'-O-methyl modified

<220>  
<221>  modified_base
<222>  (17)..(17)
<223>  2'-O-methyl modified

<220>  
<221>  modified_base
<222>  (18)..(18)
<223>  2'-O-methyl modified

<220>  
<221>  modified_base
<222>  (19)..(19)
<223>  2'-O-methyl modified

<220>
<221>  misc_feature
<222>  (20)..(22)
<223>  linked via phosphorothioate

<220>  
<221>  modified_base
<222>  (20)..(20)
<223>  2'-O-methyl modified

<220>  
<221>  modified_base
<222>  (21)..(21)
<223>  2'-O-methyl modified

<220>  
<221>  modified_base
<222>  (22)..(22)
<223>  2'-O-methyl modified

<400>  1113
uuucucaguc uguuccacuu gg                                                22


<210>  1114
<211>  22
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  Modified antisense strand


<220>
<221>  misc_feature
<222>  (1)..(4)
<223>  linked via phosphorothioate

<220>  
<221>  modified_base
<222>  (1)..(1)
<223>  5'-methoxyphosphonate-4-oxy modified

<220>  
<221>  modified_base
<222>  (2)..(2)
<223>  2'-fluoro modified

<220>  
<221>  modified_base
<222>  (3)..(3)
<223>  2'-fluoro modified

<220>  
<221>  modified_base
<222>  (4)..(4)
<223>  2'-fluoro modified

<220>  
<221>  modified_base
<222>  (5)..(5)
<223>  2'-fluoro modified

<220>  
<221>  modified_base
<222>  (6)..(6)
<223>  2'-O-methyl modified

<220>  
<221>  modified_base
<222>  (7)..(7)
<223>  2'-fluoro modified

<220>  
<221>  modified_base
<222>  (8)..(8)
<223>  2'-O-methyl modified

<220>  
<221>  modified_base
<222>  (9)..(9)
<223>  2'-O-methyl modified

<220>  
<221>  modified_base
<222>  (10)..(10)
<223>  2'-fluoro modified

<220>  
<221>  modified_base
<222>  (11)..(11)
<223>  2'-O-methyl modified

<220>  
<221>  modified_base
<222>  (12)..(12)
<223>  2'-O-methyl modified

<220>  
<221>  modified_base
<222>  (13)..(13)
<223>  2'-O-methyl modified

<220>  
<221>  modified_base
<222>  (14)..(14)
<223>  2'-fluoro modified

<220>  
<221>  modified_base
<222>  (15)..(15)
<223>  2'-O-methyl modified

<220>  
<221>  modified_base
<222>  (16)..(16)
<223>  2'-O-methyl modified

<220>  
<221>  modified_base
<222>  (17)..(17)
<223>  2'-O-methyl modified

<220>  
<221>  modified_base
<222>  (18)..(18)
<223>  2'-O-methyl modified

<220>  
<221>  modified_base
<222>  (19)..(19)
<223>  2'-O-methyl modified

<220>
<221>  misc_feature
<222>  (20)..(22)
<223>  linked via phosphorothioate

<220>  
<221>  modified_base
<222>  (20)..(20)
<223>  2'-O-methyl modified

<220>  
<221>  modified_base
<222>  (21)..(21)
<223>  2'-O-methyl modified

<220>  
<221>  modified_base
<222>  (22)..(22)
<223>  2'-O-methyl modified

<400>  1114
ucuucucagu cuguuccacu gg                                                22


<210>  1115
<211>  22
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  Modified antisense strand


<220>
<221>  misc_feature
<222>  (1)..(4)
<223>  linked via phosphorothioate

<220>  
<221>  modified_base
<222>  (1)..(1)
<223>  5'-methoxyphosphonate-4-oxy modified

<220>  
<221>  modified_base
<222>  (2)..(2)
<223>  2'-fluoro modified

<220>  
<221>  modified_base
<222>  (3)..(3)
<223>  2'-fluoro modified

<220>  
<221>  modified_base
<222>  (4)..(4)
<223>  2'-fluoro modified

<220>  
<221>  modified_base
<222>  (5)..(5)
<223>  2'-fluoro modified

<220>  
<221>  modified_base
<222>  (6)..(6)
<223>  2'-O-methyl modified

<220>  
<221>  modified_base
<222>  (7)..(7)
<223>  2'-fluoro modified

<220>  
<221>  modified_base
<222>  (8)..(8)
<223>  2'-O-methyl modified

<220>  
<221>  modified_base
<222>  (9)..(9)
<223>  2'-O-methyl modified

<220>  
<221>  modified_base
<222>  (10)..(10)
<223>  2'-fluoro modified

<220>  
<221>  modified_base
<222>  (11)..(11)
<223>  2'-O-methyl modified

<220>  
<221>  modified_base
<222>  (12)..(12)
<223>  2'-O-methyl modified

<220>  
<221>  modified_base
<222>  (13)..(13)
<223>  2'-O-methyl modified

<220>  
<221>  modified_base
<222>  (14)..(14)
<223>  2'-fluoro modified

<220>  
<221>  modified_base
<222>  (15)..(15)
<223>  2'-O-methyl modified

<220>  
<221>  modified_base
<222>  (16)..(16)
<223>  2'-O-methyl modified

<220>  
<221>  modified_base
<222>  (17)..(17)
<223>  2'-O-methyl modified

<220>  
<221>  modified_base
<222>  (18)..(18)
<223>  2'-O-methyl modified

<220>  
<221>  modified_base
<222>  (19)..(19)
<223>  2'-O-methyl modified

<220>
<221>  misc_feature
<222>  (20)..(22)
<223>  linked via phosphorothioate

<220>  
<221>  modified_base
<222>  (20)..(20)
<223>  2'-O-methyl modified

<220>  
<221>  modified_base
<222>  (21)..(21)
<223>  2'-O-methyl modified

<220>  
<221>  modified_base
<222>  (22)..(22)
<223>  2'-O-methyl modified

<400>  1115
uccuucucag ucuguuccac gg                                                22


<210>  1116
<211>  22
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  Modified antisense strand


<220>
<221>  misc_feature
<222>  (1)..(4)
<223>  linked via phosphorothioate

<220>  
<221>  modified_base
<222>  (1)..(1)
<223>  5'-methoxyphosphonate-4-oxy modified

<220>  
<221>  modified_base
<222>  (2)..(2)
<223>  2'-fluoro modified

<220>  
<221>  modified_base
<222>  (3)..(3)
<223>  2'-fluoro modified

<220>  
<221>  modified_base
<222>  (4)..(4)
<223>  2'-fluoro modified

<220>  
<221>  modified_base
<222>  (5)..(5)
<223>  2'-fluoro modified

<220>  
<221>  modified_base
<222>  (6)..(6)
<223>  2'-O-methyl modified

<220>  
<221>  modified_base
<222>  (7)..(7)
<223>  2'-fluoro modified

<220>  
<221>  modified_base
<222>  (8)..(8)
<223>  2'-O-methyl modified

<220>  
<221>  modified_base
<222>  (9)..(9)
<223>  2'-O-methyl modified

<220>  
<221>  modified_base
<222>  (10)..(10)
<223>  2'-fluoro modified

<220>  
<221>  modified_base
<222>  (11)..(11)
<223>  2'-O-methyl modified

<220>  
<221>  modified_base
<222>  (12)..(12)
<223>  2'-O-methyl modified

<220>  
<221>  modified_base
<222>  (13)..(13)
<223>  2'-O-methyl modified

<220>  
<221>  modified_base
<222>  (14)..(14)
<223>  2'-fluoro modified

<220>  
<221>  modified_base
<222>  (15)..(15)
<223>  2'-O-methyl modified

<220>  
<221>  modified_base
<222>  (16)..(16)
<223>  2'-O-methyl modified

<220>  
<221>  modified_base
<222>  (17)..(17)
<223>  2'-O-methyl modified

<220>  
<221>  modified_base
<222>  (18)..(18)
<223>  2'-O-methyl modified

<220>  
<221>  modified_base
<222>  (19)..(19)
<223>  2'-O-methyl modified

<220>
<221>  misc_feature
<222>  (20)..(22)
<223>  linked via phosphorothioate

<220>  
<221>  modified_base
<222>  (20)..(20)
<223>  2'-O-methyl modified

<220>  
<221>  modified_base
<222>  (21)..(21)
<223>  2'-O-methyl modified

<220>  
<221>  modified_base
<222>  (22)..(22)
<223>  2'-O-methyl modified

<400>  1116
ucccuucuca gucuguucca gg                                                22


<210>  1117
<211>  22
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  Modified antisense strand


<220>
<221>  misc_feature
<222>  (1)..(4)
<223>  linked via phosphorothioate

<220>  
<221>  modified_base
<222>  (1)..(1)
<223>  5'-methoxyphosphonate-4-oxy modified

<220>  
<221>  modified_base
<222>  (2)..(2)
<223>  2'-fluoro modified

<220>  
<221>  modified_base
<222>  (3)..(3)
<223>  2'-fluoro modified

<220>  
<221>  modified_base
<222>  (4)..(4)
<223>  2'-fluoro modified

<220>  
<221>  modified_base
<222>  (5)..(5)
<223>  2'-fluoro modified

<220>  
<221>  modified_base
<222>  (6)..(6)
<223>  2'-O-methyl modified

<220>  
<221>  modified_base
<222>  (7)..(7)
<223>  2'-fluoro modified

<220>  
<221>  modified_base
<222>  (8)..(8)
<223>  2'-O-methyl modified

<220>  
<221>  modified_base
<222>  (9)..(9)
<223>  2'-O-methyl modified

<220>  
<221>  modified_base
<222>  (10)..(10)
<223>  2'-fluoro modified

<220>  
<221>  modified_base
<222>  (11)..(11)
<223>  2'-O-methyl modified

<220>  
<221>  modified_base
<222>  (12)..(12)
<223>  2'-O-methyl modified

<220>  
<221>  modified_base
<222>  (13)..(13)
<223>  2'-O-methyl modified

<220>  
<221>  modified_base
<222>  (14)..(14)
<223>  2'-fluoro modified

<220>  
<221>  modified_base
<222>  (15)..(15)
<223>  2'-O-methyl modified

<220>  
<221>  modified_base
<222>  (16)..(16)
<223>  2'-O-methyl modified

<220>  
<221>  modified_base
<222>  (17)..(17)
<223>  2'-O-methyl modified

<220>  
<221>  modified_base
<222>  (18)..(18)
<223>  2'-O-methyl modified

<220>  
<221>  modified_base
<222>  (19)..(19)
<223>  2'-O-methyl modified

<220>
<221>  misc_feature
<222>  (20)..(22)
<223>  linked via phosphorothioate

<220>  
<221>  modified_base
<222>  (20)..(20)
<223>  2'-O-methyl modified

<220>  
<221>  modified_base
<222>  (21)..(21)
<223>  2'-O-methyl modified

<220>  
<221>  modified_base
<222>  (22)..(22)
<223>  2'-O-methyl modified

<400>  1117
uugcccuucu cagucuguuc gg                                                22


<210>  1118
<211>  22
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  Modified antisense strand


<220>
<221>  misc_feature
<222>  (1)..(4)
<223>  linked via phosphorothioate

<220>  
<221>  modified_base
<222>  (1)..(1)
<223>  5'-methoxyphosphonate-4-oxy modified

<220>  
<221>  modified_base
<222>  (2)..(2)
<223>  2'-fluoro modified

<220>  
<221>  modified_base
<222>  (3)..(3)
<223>  2'-fluoro modified

<220>  
<221>  modified_base
<222>  (4)..(4)
<223>  2'-fluoro modified

<220>  
<221>  modified_base
<222>  (5)..(5)
<223>  2'-fluoro modified

<220>  
<221>  modified_base
<222>  (6)..(6)
<223>  2'-O-methyl modified

<220>  
<221>  modified_base
<222>  (7)..(7)
<223>  2'-fluoro modified

<220>  
<221>  modified_base
<222>  (8)..(8)
<223>  2'-O-methyl modified

<220>  
<221>  modified_base
<222>  (9)..(9)
<223>  2'-O-methyl modified

<220>  
<221>  modified_base
<222>  (10)..(10)
<223>  2'-fluoro modified

<220>  
<221>  modified_base
<222>  (11)..(11)
<223>  2'-O-methyl modified

<220>  
<221>  modified_base
<222>  (12)..(12)
<223>  2'-O-methyl modified

<220>  
<221>  modified_base
<222>  (13)..(13)
<223>  2'-O-methyl modified

<220>  
<221>  modified_base
<222>  (14)..(14)
<223>  2'-fluoro modified

<220>  
<221>  modified_base
<222>  (15)..(15)
<223>  2'-O-methyl modified

<220>  
<221>  modified_base
<222>  (16)..(16)
<223>  2'-O-methyl modified

<220>  
<221>  modified_base
<222>  (17)..(17)
<223>  2'-O-methyl modified

<220>  
<221>  modified_base
<222>  (18)..(18)
<223>  2'-O-methyl modified

<220>  
<221>  modified_base
<222>  (19)..(19)
<223>  2'-O-methyl modified

<220>
<221>  misc_feature
<222>  (20)..(22)
<223>  linked via phosphorothioate

<220>  
<221>  modified_base
<222>  (20)..(20)
<223>  2'-O-methyl modified

<220>  
<221>  modified_base
<222>  (21)..(21)
<223>  2'-O-methyl modified

<220>  
<221>  modified_base
<222>  (22)..(22)
<223>  2'-O-methyl modified

<400>  1118
uaauguuugc ccuucucagu gg                                                22


<210>  1119
<211>  22
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  Modified antisense strand


<220>
<221>  misc_feature
<222>  (1)..(4)
<223>  linked via phosphorothioate

<220>  
<221>  modified_base
<222>  (1)..(1)
<223>  5'-methoxyphosphonate-4-oxy modified

<220>  
<221>  modified_base
<222>  (2)..(2)
<223>  2'-fluoro modified

<220>  
<221>  modified_base
<222>  (3)..(3)
<223>  2'-fluoro modified

<220>  
<221>  modified_base
<222>  (4)..(4)
<223>  2'-fluoro modified

<220>  
<221>  modified_base
<222>  (5)..(5)
<223>  2'-fluoro modified

<220>  
<221>  modified_base
<222>  (6)..(6)
<223>  2'-O-methyl modified

<220>  
<221>  modified_base
<222>  (7)..(7)
<223>  2'-fluoro modified

<220>  
<221>  modified_base
<222>  (8)..(8)
<223>  2'-O-methyl modified

<220>  
<221>  modified_base
<222>  (9)..(9)
<223>  2'-O-methyl modified

<220>  
<221>  modified_base
<222>  (10)..(10)
<223>  2'-fluoro modified

<220>  
<221>  modified_base
<222>  (11)..(11)
<223>  2'-O-methyl modified

<220>  
<221>  modified_base
<222>  (12)..(12)
<223>  2'-O-methyl modified

<220>  
<221>  modified_base
<222>  (13)..(13)
<223>  2'-O-methyl modified

<220>  
<221>  modified_base
<222>  (14)..(14)
<223>  2'-fluoro modified

<220>  
<221>  modified_base
<222>  (15)..(15)
<223>  2'-O-methyl modified

<220>  
<221>  modified_base
<222>  (16)..(16)
<223>  2'-O-methyl modified

<220>  
<221>  modified_base
<222>  (17)..(17)
<223>  2'-O-methyl modified

<220>  
<221>  modified_base
<222>  (18)..(18)
<223>  2'-O-methyl modified

<220>  
<221>  modified_base
<222>  (19)..(19)
<223>  2'-O-methyl modified

<220>
<221>  misc_feature
<222>  (20)..(22)
<223>  linked via phosphorothioate

<220>  
<221>  modified_base
<222>  (20)..(20)
<223>  2'-O-methyl modified

<220>  
<221>  modified_base
<222>  (21)..(21)
<223>  2'-O-methyl modified

<220>  
<221>  modified_base
<222>  (22)..(22)
<223>  2'-O-methyl modified

<400>  1119
ugacucucuu uuaaugccac gg                                                22


<210>  1120
<211>  22
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  Modified antisense strand


<220>
<221>  misc_feature
<222>  (1)..(4)
<223>  linked via phosphorothioate

<220>  
<221>  modified_base
<222>  (1)..(1)
<223>  5'-methoxyphosphonate-4-oxy modified

<220>  
<221>  modified_base
<222>  (2)..(2)
<223>  2'-fluoro modified

<220>  
<221>  modified_base
<222>  (3)..(3)
<223>  2'-fluoro modified

<220>  
<221>  modified_base
<222>  (4)..(4)
<223>  2'-fluoro modified

<220>  
<221>  modified_base
<222>  (5)..(5)
<223>  2'-fluoro modified

<220>  
<221>  modified_base
<222>  (6)..(6)
<223>  2'-O-methyl modified

<220>  
<221>  modified_base
<222>  (7)..(7)
<223>  2'-fluoro modified

<220>  
<221>  modified_base
<222>  (8)..(8)
<223>  2'-O-methyl modified

<220>  
<221>  modified_base
<222>  (9)..(9)
<223>  2'-O-methyl modified

<220>  
<221>  modified_base
<222>  (10)..(10)
<223>  2'-fluoro modified

<220>  
<221>  modified_base
<222>  (11)..(11)
<223>  2'-O-methyl modified

<220>  
<221>  modified_base
<222>  (12)..(12)
<223>  2'-O-methyl modified

<220>  
<221>  modified_base
<222>  (13)..(13)
<223>  2'-O-methyl modified

<220>  
<221>  modified_base
<222>  (14)..(14)
<223>  2'-fluoro modified

<220>  
<221>  modified_base
<222>  (15)..(15)
<223>  2'-O-methyl modified

<220>  
<221>  modified_base
<222>  (16)..(16)
<223>  2'-O-methyl modified

<220>  
<221>  modified_base
<222>  (17)..(17)
<223>  2'-O-methyl modified

<220>  
<221>  modified_base
<222>  (18)..(18)
<223>  2'-O-methyl modified

<220>  
<221>  modified_base
<222>  (19)..(19)
<223>  2'-O-methyl modified

<220>
<221>  misc_feature
<222>  (20)..(22)
<223>  linked via phosphorothioate

<220>  
<221>  modified_base
<222>  (20)..(20)
<223>  2'-O-methyl modified

<220>  
<221>  modified_base
<222>  (21)..(21)
<223>  2'-O-methyl modified

<220>  
<221>  modified_base
<222>  (22)..(22)
<223>  2'-O-methyl modified

<400>  1120
uugacucucu uuuaaugcca gg                                                22


<210>  1121
<211>  16
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  Stem-loop

<400>  1121
gcagccgaaa ggcugc                                                       16


<210>  1122
<211>  22
<212>  DNA
<213>  Artificial Sequence

<220>  
<223>  Forward-1198

<400>  1122
gttataaccg ggaagacttt gc                                                22


<210>  1123
<211>  20
<212>  DNA
<213>  Artificial Sequence

<220>  
<223>  Reverse-1326

<400>  1123
tgatagcaat gagcaaggca                                                   20


<210>  1124
<211>  24
<212>  DNA
<213>  Artificial Sequence

<220>  
<223>  Probe-1253

<400>  1124
atggccctgg agaactcgaa gatg                                              24


<210>  1125
<211>  19
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  19 mer sense strand

<400>  1125
uguccuguca gaagaacag                                                    19


<210>  1126
<211>  19
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  19 mer sense strand

<400>  1126
uccugucaga agaacagau                                                    19


<210>  1127
<211>  19
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  19 mer sense strand

<400>  1127
cugaagaaac ugaagcggc                                                    19


<210>  1128
<211>  19
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  19 mer sense strand

<400>  1128
ugaagaaacu gaagcggca                                                    19


<210>  1129
<211>  19
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  19 mer sense strand

<400>  1129
gaagaaacug aagcggcaa                                                    19


<210>  1130
<211>  19
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  19 mer sense strand

<400>  1130
aagaaacuga agcggcaag                                                    19


<210>  1131
<211>  19
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  19 mer sense strand

<400>  1131
agaaacugaa gcggcaaga                                                    19


<210>  1132
<211>  19
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  19 mer sense strand

<400>  1132
aaacugaagc ggcaagagg                                                    19


<210>  1133
<211>  19
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  19 mer sense strand

<400>  1133
aacugaagcg gcaagagga                                                    19


<210>  1134
<211>  19
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  19 mer sense strand

<400>  1134
acugaagcgg caagaggag                                                    19


<210>  1135
<211>  19
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  19 mer sense strand

<400>  1135
cugaagcggc aagaggagg                                                    19


<210>  1136
<211>  19
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  19 mer sense strand

<400>  1136
ugaagcggca agaggagga                                                    19


<210>  1137
<211>  19
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  19 mer sense strand

<400>  1137
agcggcaaga ggaggaaca                                                    19


<210>  1138
<211>  19
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  19 mer sense strand

<400>  1138
gcggcaagag gaggaacag                                                    19


<210>  1139
<211>  19
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  19 mer sense strand

<400>  1139
cggcaagagg aggaacagg                                                    19


<210>  1140
<211>  19
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  19 mer sense strand

<400>  1140
gcaagaggag gaacaggcu                                                    19


<210>  1141
<211>  19
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  19 mer sense strand

<400>  1141
aagaggagga acaggcuca                                                    19


<210>  1142
<211>  19
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  19 mer sense strand

<400>  1142
agaggaggaa caggcucau                                                    19


<210>  1143
<211>  19
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  19 mer sense strand

<400>  1143
gaggaggaac aggcucaug                                                    19


<210>  1144
<211>  19
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  19 mer sense strand

<400>  1144
aggaggaaca ggcucaugc                                                    19


<210>  1145
<211>  19
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  19 mer sense strand

<400>  1145
gaggaacagg cucaugcca                                                    19


<210>  1146
<211>  19
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  19 mer sense strand

<400>  1146
ccagggcuuc cucaccccc                                                    19


<210>  1147
<211>  19
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  19 mer sense strand

<400>  1147
ugggcaugau cgagaagcu                                                    19


<210>  1148
<211>  19
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  19 mer sense strand

<400>  1148
gcaugaucga gaagcucgu                                                    19


<210>  1149
<211>  19
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  19 mer sense strand

<400>  1149
gucgcugccc agcaacagu                                                    19


<210>  1150
<211>  19
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  19 mer sense strand

<400>  1150
cgcugcccag caacagugu                                                    19


<210>  1151
<211>  19
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  19 mer sense strand

<400>  1151
cccagcaaca guguaaccg                                                    19


<210>  1152
<211>  19
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  19 mer sense strand

<400>  1152
cagcaacagu guaaccggc                                                    19


<210>  1153
<211>  19
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  19 mer sense strand

<400>  1153
agcaacagug uaaccggcg                                                    19


<210>  1154
<211>  19
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  19 mer sense strand

<400>  1154
caacagugua accggcgcu                                                    19


<210>  1155
<211>  19
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  19 mer sense strand

<400>  1155
aacaguguaa ccggcgcuc                                                    19


<210>  1156
<211>  19
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  19 mer sense strand

<400>  1156
acaguguaac cggcgcucc                                                    19


<210>  1157
<211>  19
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  19 mer sense strand

<400>  1157
caguguaacc ggcgcuccu                                                    19


<210>  1158
<211>  19
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  19 mer sense strand

<400>  1158
aguguaaccg gcgcuccuu                                                    19


<210>  1159
<211>  19
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  19 mer sense strand

<400>  1159
guguaaccgg cgcuccuuu                                                    19


<210>  1160
<211>  19
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  19 mer sense strand

<400>  1160
uguaaccggc gcuccuuuu                                                    19


<210>  1161
<211>  19
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  19 mer sense strand

<400>  1161
gcgcuccuuu ucugaccgg                                                    19


<210>  1162
<211>  19
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  19 mer sense strand

<400>  1162
cuccuuuucu gaccggcuu                                                    19


<210>  1163
<211>  19
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  19 mer sense strand

<400>  1163
uccuuuucug accggcuuc                                                    19


<210>  1164
<211>  19
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  19 mer sense strand

<400>  1164
ccuuuucuga ccggcuucg                                                    19


<210>  1165
<211>  19
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  19 mer sense strand

<400>  1165
cuuuucugac cggcuucga                                                    19


<210>  1166
<211>  19
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  19 mer sense strand

<400>  1166
uuucugaccg gcuucgagu                                                    19


<210>  1167
<211>  19
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  19 mer sense strand

<400>  1167
ucugaccggc uucgaguca                                                    19


<210>  1168
<211>  19
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  19 mer sense strand

<400>  1168
cugaccggcu ucgagucac                                                    19


<210>  1169
<211>  19
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  19 mer sense strand

<400>  1169
ugaccggcuu cgagucacg                                                    19


<210>  1170
<211>  19
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  19 mer sense strand

<400>  1170
ggugaugcuu cuggagaca                                                    19


<210>  1171
<211>  19
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  19 mer sense strand

<400>  1171
ugaugcuucu ggagacauc                                                    19


<210>  1172
<211>  19
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  19 mer sense strand

<400>  1172
gaugcuucug gagacaucu                                                    19


<210>  1173
<211>  19
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  19 mer sense strand

<400>  1173
augcuucugg agacaucuc                                                    19


<210>  1174
<211>  19
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  19 mer sense strand

<400>  1174
ugcuucugga gacaucucg                                                    19


<210>  1175
<211>  19
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  19 mer sense strand

<400>  1175
gcuucuggag acaucucgg                                                    19


<210>  1176
<211>  19
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  19 mer sense strand

<400>  1176
cuucuggaga caucucgga                                                    19


<210>  1177
<211>  19
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  19 mer sense strand

<400>  1177
uucuggagac aucucggag                                                    19


<210>  1178
<211>  19
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  19 mer sense strand

<400>  1178
ucuggagaca ucucggagg                                                    19


<210>  1179
<211>  19
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  19 mer sense strand

<400>  1179
cuggagacau cucggaggu                                                    19


<210>  1180
<211>  19
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  19 mer sense strand

<400>  1180
uggagacauc ucggaggua                                                    19


<210>  1181
<211>  19
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  19 mer sense strand

<400>  1181
ggagacaucu cggagguac                                                    19


<210>  1182
<211>  19
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  19 mer sense strand

<400>  1182
gagacaucuc ggagguaca                                                    19


<210>  1183
<211>  19
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  19 mer sense strand

<400>  1183
agacaucucg gagguacaa                                                    19


<210>  1184
<211>  19
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  19 mer sense strand

<400>  1184
gacaucucgg agguacaac                                                    19


<210>  1185
<211>  19
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  19 mer sense strand

<400>  1185
acaucucgga gguacaacc                                                    19


<210>  1186
<211>  19
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  19 mer sense strand

<400>  1186
aucucggagg uacaacccu                                                    19


<210>  1187
<211>  19
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  19 mer sense strand

<400>  1187
ucucggaggu acaacccug                                                    19


<210>  1188
<211>  19
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  19 mer sense strand

<400>  1188
cucggaggua caacccugg                                                    19


<210>  1189
<211>  19
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  19 mer sense strand

<400>  1189
cggagguaca acccuggga                                                    19


<210>  1190
<211>  19
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  19 mer sense strand

<400>  1190
gagguacaac ccugggagu                                                    19


<210>  1191
<211>  19
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  19 mer sense strand

<400>  1191
agguacaacc cugggagug                                                    19


<210>  1192
<211>  19
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  19 mer sense strand

<400>  1192
gguacaaccc ugggaguga                                                    19


<210>  1193
<211>  19
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  19 mer sense strand

<400>  1193
guacaacccu gggagugag                                                    19


<210>  1194
<211>  19
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  19 mer sense strand

<400>  1194
uacaacccug ggagugaga                                                    19


<210>  1195
<211>  19
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  19 mer sense strand

<400>  1195
acaacccugg gagugagag                                                    19


<210>  1196
<211>  19
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  19 mer sense strand

<400>  1196
caacccuggg agugagagu                                                    19


<210>  1197
<211>  19
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  19 mer sense strand

<400>  1197
aacccuggga gugagagua                                                    19


<210>  1198
<211>  19
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  19 mer sense strand

<400>  1198
acccugggag ugagaguau                                                    19


<210>  1199
<211>  19
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  19 mer sense strand

<400>  1199
cccugggagu gagaguauc                                                    19


<210>  1200
<211>  19
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  19 mer sense strand

<400>  1200
ccugggagug agaguauca                                                    19


<210>  1201
<211>  19
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  19 mer sense strand

<400>  1201
cugggaguga gaguaucac                                                    19


<210>  1202
<211>  19
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  19 mer sense strand

<400>  1202
ugggagugag aguaucacc                                                    19


<210>  1203
<211>  19
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  19 mer sense strand

<400>  1203
gggagugaga guaucaccu                                                    19


<210>  1204
<211>  19
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  19 mer sense strand

<400>  1204
gagugagagu aucaccuuc                                                    19


<210>  1205
<211>  19
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  19 mer sense strand

<400>  1205
agugagagua ucaccuucc                                                    19


<210>  1206
<211>  19
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  19 mer sense strand

<400>  1206
gugagaguau caccuuccu                                                    19


<210>  1207
<211>  19
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  19 mer sense strand

<400>  1207
ugagaguauc accuuccuc                                                    19


<210>  1208
<211>  19
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  19 mer sense strand

<400>  1208
gagaguauca ccuuccuca                                                    19


<210>  1209
<211>  19
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  19 mer sense strand

<400>  1209
gaguaucacc uuccucaag                                                    19


<210>  1210
<211>  19
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  19 mer sense strand

<400>  1210
aguaucaccu uccucaagg                                                    19


<210>  1211
<211>  19
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  19 mer sense strand

<400>  1211
guaucaccuu ccucaagga                                                    19


<210>  1212
<211>  19
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  19 mer sense strand

<400>  1212
uaucaccuuc cucaaggau                                                    19


<210>  1213
<211>  19
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  19 mer sense strand

<400>  1213
aucaccuucc ucaaggauu                                                    19


<210>  1214
<211>  19
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  19 mer sense strand

<400>  1214
accuuccuca aggauuuca                                                    19


<210>  1215
<211>  19
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  19 mer sense strand

<400>  1215
ccuuccucaa ggauuucag                                                    19


<210>  1216
<211>  19
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  19 mer sense strand

<400>  1216
uccucaagga uuucaguua                                                    19


<210>  1217
<211>  19
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  19 mer sense strand

<400>  1217
caaggauuuc aguuauaac                                                    19


<210>  1218
<211>  19
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  19 mer sense strand

<400>  1218
aaggauuuca guuauaacc                                                    19


<210>  1219
<211>  19
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  19 mer sense strand

<400>  1219
aggauuucag uuauaaccg                                                    19


<210>  1220
<211>  19
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  19 mer sense strand

<400>  1220
ggauuucagu uauaaccgg                                                    19


<210>  1221
<211>  19
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  19 mer sense strand

<400>  1221
gauuucaguu auaaccggg                                                    19


<210>  1222
<211>  19
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  19 mer sense strand

<400>  1222
auuucaguua uaaccggga                                                    19


<210>  1223
<211>  19
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  19 mer sense strand

<400>  1223
uuucaguuau aaccgggaa                                                    19


<210>  1224
<211>  19
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  19 mer sense strand

<400>  1224
uucaguuaua accgggaag                                                    19


<210>  1225
<211>  19
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  19 mer sense strand

<400>  1225
ucaguuauaa ccgggaaga                                                    19


<210>  1226
<211>  19
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  19 mer sense strand

<400>  1226
caguuauaac cgggaagac                                                    19


<210>  1227
<211>  19
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  19 mer sense strand

<400>  1227
guuauaaccg ggaagacuu                                                    19


<210>  1228
<211>  19
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  19 mer sense strand

<400>  1228
uuauaaccgg gaagacuuu                                                    19


<210>  1229
<211>  19
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  19 mer sense strand

<400>  1229
uauaaccggg aagacuuug                                                    19


<210>  1230
<211>  19
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  19 mer sense strand

<400>  1230
auaaccggga agacuuugc                                                    19


<210>  1231
<211>  19
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  19 mer sense strand

<400>  1231
uaaccgggaa gacuuugcc                                                    19


<210>  1232
<211>  19
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  19 mer sense strand

<400>  1232
aaccgggaag acuuugcca                                                    19


<210>  1233
<211>  19
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  19 mer sense strand

<400>  1233
accgggaaga cuuugccaa                                                    19


<210>  1234
<211>  19
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  19 mer sense strand

<400>  1234
ccgggaagac uuugccaaa                                                    19


<210>  1235
<211>  19
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  19 mer sense strand

<400>  1235
ggaagacuuu gccaaagca                                                    19


<210>  1236
<211>  19
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  19 mer sense strand

<400>  1236
gaagacuuug ccaaagcag                                                    19


<210>  1237
<211>  19
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  19 mer sense strand

<400>  1237
aagacuuugc caaagcagg                                                    19


<210>  1238
<211>  19
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  19 mer sense strand

<400>  1238
agacuuugcc aaagcaggg                                                    19


<210>  1239
<211>  19
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  19 mer sense strand

<400>  1239
gacuuugcca aagcagggc                                                    19


<210>  1240
<211>  19
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  19 mer sense strand

<400>  1240
acuuugccaa agcagggcu                                                    19


<210>  1241
<211>  19
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  19 mer sense strand

<400>  1241
cuuugccaaa gcagggcug                                                    19


<210>  1242
<211>  19
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  19 mer sense strand

<400>  1242
ugccaaagca gggcugcaa                                                    19


<210>  1243
<211>  19
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  19 mer sense strand

<400>  1243
gccaaagcag ggcugcaag                                                    19


<210>  1244
<211>  19
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  19 mer sense strand

<400>  1244
ccaaagcagg gcugcaagu                                                    19


<210>  1245
<211>  19
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  19 mer sense strand

<400>  1245
caaagcaggg cugcaagug                                                    19


<210>  1246
<211>  19
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  19 mer sense strand

<400>  1246
aaagcagggc ugcaagugg                                                    19


<210>  1247
<211>  19
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  19 mer sense strand

<400>  1247
aagcagggcu gcaagugga                                                    19


<210>  1248
<211>  19
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  19 mer sense strand

<400>  1248
agcagggcug caaguggaa                                                    19


<210>  1249
<211>  19
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  19 mer sense strand

<400>  1249
gcagggcugc aaguggaau                                                    19


<210>  1250
<211>  19
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  19 mer sense strand

<400>  1250
agggcugcaa guggaauuc                                                    19


<210>  1251
<211>  19
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  19 mer sense strand

<400>  1251
gggcugcaag uggaauuca                                                    19


<210>  1252
<211>  19
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  19 mer sense strand

<400>  1252
ggcugcaagu ggaauucau                                                    19


<210>  1253
<211>  19
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  19 mer sense strand

<400>  1253
gcugcaagug gaauucauc                                                    19


<210>  1254
<211>  19
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  19 mer sense strand

<400>  1254
gcaaguggaa uucaucaac                                                    19


<210>  1255
<211>  19
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  19 mer sense strand

<400>  1255
aaguggaauu caucaaccc                                                    19


<210>  1256
<211>  19
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  19 mer sense strand

<400>  1256
aguggaauuc aucaacccc                                                    19


<210>  1257
<211>  19
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  19 mer sense strand

<400>  1257
uggaauucau caaccccau                                                    19


<210>  1258
<211>  19
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  19 mer sense strand

<400>  1258
ggaauucauc aaccccauc                                                    19


<210>  1259
<211>  19
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  19 mer sense strand

<400>  1259
auucaucaac cccaucuuc                                                    19


<210>  1260
<211>  19
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  19 mer sense strand

<400>  1260
uucaucaacc ccaucuucg                                                    19


<210>  1261
<211>  19
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  19 mer sense strand

<400>  1261
ucaucaaccc caucuucga                                                    19


<210>  1262
<211>  19
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  19 mer sense strand

<400>  1262
caucaacccc aucuucgag                                                    19


<210>  1263
<211>  19
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  19 mer sense strand

<400>  1263
aucaacccca ucuucgagu                                                    19


<210>  1264
<211>  19
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  19 mer sense strand

<400>  1264
ucaaccccau cuucgaguu                                                    19


<210>  1265
<211>  19
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  19 mer sense strand

<400>  1265
caaccccauc uucgaguuc                                                    19


<210>  1266
<211>  19
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  19 mer sense strand

<400>  1266
aaccccaucu ucgaguucu                                                    19


<210>  1267
<211>  19
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  19 mer sense strand

<400>  1267
accccaucuu cgaguucuc                                                    19


<210>  1268
<211>  19
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  19 mer sense strand

<400>  1268
cccaucuucg aguucucca                                                    19


<210>  1269
<211>  19
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  19 mer sense strand

<400>  1269
ccaucuucga guucuccag                                                    19


<210>  1270
<211>  19
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  19 mer sense strand

<400>  1270
caucuucgag uucuccagg                                                    19


<210>  1271
<211>  19
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  19 mer sense strand

<400>  1271
aucuucgagu ucuccaggg                                                    19


<210>  1272
<211>  19
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  19 mer sense strand

<400>  1272
ucuucgaguu cuccagggc                                                    19


<210>  1273
<211>  19
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  19 mer sense strand

<400>  1273
cuucgaguuc uccagggcc                                                    19


<210>  1274
<211>  19
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  19 mer sense strand

<400>  1274
uucgaguucu ccagggcca                                                    19


<210>  1275
<211>  19
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  19 mer sense strand

<400>  1275
ucgaguucuc cagggccau                                                    19


<210>  1276
<211>  19
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  19 mer sense strand

<400>  1276
cgaguucucc agggccaug                                                    19


<210>  1277
<211>  19
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  19 mer sense strand

<400>  1277
gaguucucca gggccauga                                                    19


<210>  1278
<211>  19
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  19 mer sense strand

<400>  1278
aguucuccag ggccaugaa                                                    19


<210>  1279
<211>  19
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  19 mer sense strand

<400>  1279
guucuccagg gccaugaau                                                    19


<210>  1280
<211>  19
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  19 mer sense strand

<400>  1280
ucuccagggc caugaauga                                                    19


<210>  1281
<211>  19
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  19 mer sense strand

<400>  1281
cuccagggcc augaaugag                                                    19


<210>  1282
<211>  19
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  19 mer sense strand

<400>  1282
uccagggcca ugaaugagc                                                    19


<210>  1283
<211>  19
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  19 mer sense strand

<400>  1283
ccagggccau gaaugagcu                                                    19


<210>  1284
<211>  19
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  19 mer sense strand

<400>  1284
cagggccaug aaugagcug                                                    19


<210>  1285
<211>  19
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  19 mer sense strand

<400>  1285
agggccauga augagcugc                                                    19


<210>  1286
<211>  19
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  19 mer sense strand

<400>  1286
gggccaugaa ugagcugca                                                    19


<210>  1287
<211>  19
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  19 mer sense strand

<400>  1287
ggccaugaau gagcugcaa                                                    19


<210>  1288
<211>  19
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  19 mer sense strand

<400>  1288
gccaugaaug agcugcaac                                                    19


<210>  1289
<211>  19
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  19 mer sense strand

<400>  1289
ccaugaauga gcugcaacu                                                    19


<210>  1290
<211>  19
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  19 mer sense strand

<400>  1290
cucauugcua ucagcaucu                                                    19


<210>  1291
<211>  19
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  19 mer sense strand

<400>  1291
ucauugcuau cagcaucuu                                                    19


<210>  1292
<211>  19
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  19 mer sense strand

<400>  1292
cauugcuauc agcaucuuc                                                    19


<210>  1293
<211>  19
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  19 mer sense strand

<400>  1293
auugcuauca gcaucuucu                                                    19


<210>  1294
<211>  19
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  19 mer sense strand

<400>  1294
uugcuaucag caucuucuc                                                    19


<210>  1295
<211>  19
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  19 mer sense strand

<400>  1295
ugcuaucagc aucuucucu                                                    19


<210>  1296
<211>  19
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  19 mer sense strand

<400>  1296
gcuaucagca ucuucucug                                                    19


<210>  1297
<211>  19
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  19 mer sense strand

<400>  1297
cuaucagcau cuucucugc                                                    19


<210>  1298
<211>  19
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  19 mer sense strand

<400>  1298
uaucagcauc uucucugca                                                    19


<210>  1299
<211>  19
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  19 mer sense strand

<400>  1299
aucagcaucu ucucugcag                                                    19


<210>  1300
<211>  19
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  19 mer sense strand

<400>  1300
gugcaggacc agcuccagg                                                    19


<210>  1301
<211>  19
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  19 mer sense strand

<400>  1301
gcaggaccag cuccaggua                                                    19


<210>  1302
<211>  19
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  19 mer sense strand

<400>  1302
gaccagcucc agguagaga                                                    19


<210>  1303
<211>  19
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  19 mer sense strand

<400>  1303
accagcucca gguagagag                                                    19


<210>  1304
<211>  19
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  19 mer sense strand

<400>  1304
ccagcuccag guagagagg                                                    19


<210>  1305
<211>  19
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  19 mer sense strand

<400>  1305
agcuccaggu agagaggcu                                                    19


<210>  1306
<211>  19
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  19 mer sense strand

<400>  1306
gcuccaggua gagaggcug                                                    19


<210>  1307
<211>  19
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  19 mer sense strand

<400>  1307
ccagguagag aggcugcag                                                    19


<210>  1308
<211>  19
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  19 mer sense strand

<400>  1308
agguagagag gcugcagca                                                    19


<210>  1309
<211>  19
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  19 mer sense strand

<400>  1309
gguagagagg cugcagcac                                                    19


<210>  1310
<211>  19
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  19 mer sense strand

<400>  1310
guagagaggc ugcagcaca                                                    19


<210>  1311
<211>  19
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  19 mer sense strand

<400>  1311
uagagaggcu gcagcacac                                                    19


<210>  1312
<211>  19
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  19 mer sense strand

<400>  1312
agagaggcug cagcacaca                                                    19


<210>  1313
<211>  19
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  19 mer sense strand

<400>  1313
gagaggcugc agcacacau                                                    19


<210>  1314
<211>  19
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  19 mer sense strand

<400>  1314
agaggcugca gcacacaua                                                    19


<210>  1315
<211>  19
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  19 mer sense strand

<400>  1315
gaggcugcag cacacauau                                                    19


<210>  1316
<211>  19
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  19 mer sense strand

<400>  1316
aggcugcagc acacauaug                                                    19


<210>  1317
<211>  19
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  19 mer sense strand

<400>  1317
ggcugcagca cacauaugu                                                    19


<210>  1318
<211>  19
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  19 mer sense strand

<400>  1318
gcugcagcac acauaugug                                                    19


<210>  1319
<211>  19
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  19 mer sense strand

<400>  1319
cugcagcaca cauaugugg                                                    19


<210>  1320
<211>  19
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  19 mer sense strand

<400>  1320
gcagcacaca uauguggaa                                                    19


<210>  1321
<211>  19
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  19 mer sense strand

<400>  1321
cagcacacau auguggaag                                                    19


<210>  1322
<211>  19
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  19 mer sense strand

<400>  1322
agcacacaua uguggaagc                                                    19


<210>  1323
<211>  19
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  19 mer sense strand

<400>  1323
cacacauaug uggaagccc                                                    19


<210>  1324
<211>  19
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  19 mer sense strand

<400>  1324
acacauaugu ggaagcccu                                                    19


<210>  1325
<211>  19
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  19 mer sense strand

<400>  1325
cacauaugug gaagcccug                                                    19


<210>  1326
<211>  19
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  19 mer sense strand

<400>  1326
acauaugugg aagcccugc                                                    19


<210>  1327
<211>  19
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  19 mer sense strand

<400>  1327
cauaugugga agcccugca                                                    19


<210>  1328
<211>  19
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  19 mer sense strand

<400>  1328
auauguggaa gcccugcau                                                    19


<210>  1329
<211>  19
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  19 mer sense strand

<400>  1329
uauguggaag cccugcaug                                                    19


<210>  1330
<211>  19
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  19 mer sense strand

<400>  1330
auguggaagc ccugcaugc                                                    19


<210>  1331
<211>  19
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  19 mer sense strand

<400>  1331
uguggaagcc cugcaugcc                                                    19


<210>  1332
<211>  19
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  19 mer sense strand

<400>  1332
guggaagccc ugcaugccu                                                    19


<210>  1333
<211>  19
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  19 mer sense strand

<400>  1333
uggaagcccu gcaugccua                                                    19


<210>  1334
<211>  19
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  19 mer sense strand

<400>  1334
ggaagcccug caugccuac                                                    19


<210>  1335
<211>  19
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  19 mer sense strand

<400>  1335
gaagcccugc augccuacg                                                    19


<210>  1336
<211>  19
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  19 mer sense strand

<400>  1336
aagcccugca ugccuacgu                                                    19


<210>  1337
<211>  19
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  19 mer sense strand

<400>  1337
agcccugcau gccuacguc                                                    19


<210>  1338
<211>  19
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  19 mer sense strand

<400>  1338
gcccugcaug ccuacgucu                                                    19


<210>  1339
<211>  19
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  19 mer sense strand

<400>  1339
cccugcaugc cuacgucuc                                                    19


<210>  1340
<211>  19
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  19 mer sense strand

<400>  1340
ccugcaugcc uacgucucc                                                    19


<210>  1341
<211>  19
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  19 mer sense strand

<400>  1341
cugcaugccu acgucucca                                                    19


<210>  1342
<211>  19
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  19 mer sense strand

<400>  1342
ugcaugccua cgucuccau                                                    19


<210>  1343
<211>  19
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  19 mer sense strand

<400>  1343
gcaugccuac gucuccauc                                                    19


<210>  1344
<211>  19
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  19 mer sense strand

<400>  1344
caugccuacg ucuccaucc                                                    19


<210>  1345
<211>  19
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  19 mer sense strand

<400>  1345
augccuacgu cuccaucca                                                    19


<210>  1346
<211>  19
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  19 mer sense strand

<400>  1346
ugccuacguc uccauccac                                                    19


<210>  1347
<211>  19
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  19 mer sense strand

<400>  1347
gccuacgucu ccauccacc                                                    19


<210>  1348
<211>  19
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  19 mer sense strand

<400>  1348
ccuacgucuc cauccacca                                                    19


<210>  1349
<211>  19
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  19 mer sense strand

<400>  1349
cuacgucucc auccaccau                                                    19


<210>  1350
<211>  19
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  19 mer sense strand

<400>  1350
uacgucucca uccaccauc                                                    19


<210>  1351
<211>  19
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  19 mer sense strand

<400>  1351
acgucuccau ccaccaucc                                                    19


<210>  1352
<211>  19
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  19 mer sense strand

<400>  1352
cgucuccauc caccauccc                                                    19


<210>  1353
<211>  19
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  19 mer sense strand

<400>  1353
gucuccaucc accaucccc                                                    19


<210>  1354
<211>  19
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  19 mer sense strand

<400>  1354
cuccauccac cauccccau                                                    19


<210>  1355
<211>  19
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  19 mer sense strand

<400>  1355
uccauccacc auccccaug                                                    19


<210>  1356
<211>  19
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  19 mer sense strand

<400>  1356
ccauccacca uccccauga                                                    19


<210>  1357
<211>  19
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  19 mer sense strand

<400>  1357
cauccaccau ccccaugac                                                    19


<210>  1358
<211>  19
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  19 mer sense strand

<400>  1358
auccaccauc cccaugacc                                                    19


<210>  1359
<211>  19
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  19 mer sense strand

<400>  1359
uccaccaucc ccaugaccg                                                    19


<210>  1360
<211>  19
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  19 mer sense strand

<400>  1360
ccaccauccc caugaccga                                                    19


<210>  1361
<211>  19
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  19 mer sense strand

<400>  1361
caccaucccc augaccgac                                                    19


<210>  1362
<211>  19
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  19 mer sense strand

<400>  1362
accaucccca ugaccgacu                                                    19


<210>  1363
<211>  19
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  19 mer sense strand

<400>  1363
ccauccccau gaccgacug                                                    19


<210>  1364
<211>  19
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  19 mer sense strand

<400>  1364
cauccccaug accgacuga                                                    19


<210>  1365
<211>  19
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  19 mer sense strand

<400>  1365
auccccauga ccgacugau                                                    19


<210>  1366
<211>  19
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  19 mer sense strand

<400>  1366
uccccaugac cgacugaug                                                    19


<210>  1367
<211>  19
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  19 mer sense strand

<400>  1367
ccccaugacc gacugaugu                                                    19


<210>  1368
<211>  19
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  19 mer sense strand

<400>  1368
cccaugaccg acugauguu                                                    19


<210>  1369
<211>  19
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  19 mer sense strand

<400>  1369
ccaugaccga cugauguuc                                                    19


<210>  1370
<211>  19
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  19 mer sense strand

<400>  1370
augaccgacu gauguuccc                                                    19


<210>  1371
<211>  19
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  19 mer sense strand

<400>  1371
ugaccgacug auguuccca                                                    19


<210>  1372
<211>  19
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  19 mer sense strand

<400>  1372
gaccgacuga uguucccac                                                    19


<210>  1373
<211>  19
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  19 mer sense strand

<400>  1373
accgacugau guucccacg                                                    19


<210>  1374
<211>  19
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  19 mer sense strand

<400>  1374
ccgacugaug uucccacgg                                                    19


<210>  1375
<211>  19
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  19 mer sense strand

<400>  1375
gacugauguu cccacggau                                                    19


<210>  1376
<211>  19
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  19 mer sense strand

<400>  1376
acugauguuc ccacggaug                                                    19


<210>  1377
<211>  19
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  19 mer sense strand

<400>  1377
ugauguuccc acggaugcu                                                    19


<210>  1378
<211>  19
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  19 mer sense strand

<400>  1378
gauguuccca cggaugcua                                                    19


<210>  1379
<211>  19
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  19 mer sense strand

<400>  1379
uguucccacg gaugcuaau                                                    19


<210>  1380
<211>  19
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  19 mer sense strand

<400>  1380
guucccacgg augcuaaug                                                    19


<210>  1381
<211>  19
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  19 mer sense strand

<400>  1381
uucccacgga ugcuaauga                                                    19


<210>  1382
<211>  19
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  19 mer sense strand

<400>  1382
ucccacggau gcuaaugaa                                                    19


<210>  1383
<211>  19
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  19 mer sense strand

<400>  1383
cccacggaug cuaaugaaa                                                    19


<210>  1384
<211>  19
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  19 mer sense strand

<400>  1384
ccacggaugc uaaugaaac                                                    19


<210>  1385
<211>  19
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  19 mer sense strand

<400>  1385
cacggaugcu aaugaaacu                                                    19


<210>  1386
<211>  19
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  19 mer sense strand

<400>  1386
acggaugcua augaaacug                                                    19


<210>  1387
<211>  19
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  19 mer sense strand

<400>  1387
cggaugcuaa ugaaacugg                                                    19


<210>  1388
<211>  19
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  19 mer sense strand

<400>  1388
ggaugcuaau gaaacuggu                                                    19


<210>  1389
<211>  19
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  19 mer sense strand

<400>  1389
gaugcuaaug aaacuggug                                                    19


<210>  1390
<211>  19
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  19 mer sense strand

<400>  1390
ugcuaaugaa acuggugag                                                    19


<210>  1391
<211>  19
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  19 mer sense strand

<400>  1391
gcuaaugaaa cuggugagc                                                    19


<210>  1392
<211>  19
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  19 mer sense strand

<400>  1392
cuaaugaaac uggugagcc                                                    19


<210>  1393
<211>  19
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  19 mer sense strand

<400>  1393
uaaugaaacu ggugagccu                                                    19


<210>  1394
<211>  19
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  19 mer sense strand

<400>  1394
aaugaaacug gugagccuc                                                    19


<210>  1395
<211>  19
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  19 mer sense strand

<400>  1395
augaaacugg ugagccucc                                                    19


<210>  1396
<211>  19
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  19 mer sense strand

<400>  1396
ugaaacuggu gagccuccg                                                    19


<210>  1397
<211>  19
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  19 mer sense strand

<400>  1397
aaacugguga gccuccgga                                                    19


<210>  1398
<211>  19
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  19 mer sense strand

<400>  1398
aacuggugag ccuccggac                                                    19


<210>  1399
<211>  19
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  19 mer sense strand

<400>  1399
cuggugagcc uccggaccc                                                    19


<210>  1400
<211>  19
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  19 mer sense strand

<400>  1400
ccggacccug agcagcguc                                                    19


<210>  1401
<211>  19
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  19 mer sense strand

<400>  1401
ggacccugag cagcgucca                                                    19


<210>  1402
<211>  19
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  19 mer sense strand

<400>  1402
gacccugagc agcguccac                                                    19


<210>  1403
<211>  19
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  19 mer sense strand

<400>  1403
acccugagca gcguccacu                                                    19


<210>  1404
<211>  19
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  19 mer sense strand

<400>  1404
cccugagcag cguccacuc                                                    19


<210>  1405
<211>  19
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  19 mer sense strand

<400>  1405
ccugagcagc guccacuca                                                    19


<210>  1406
<211>  19
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  19 mer sense strand

<400>  1406
cugagcagcg uccacucag                                                    19


<210>  1407
<211>  19
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  19 mer sense strand

<400>  1407
ugagcagcgu ccacucaga                                                    19


<210>  1408
<211>  19
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  19 mer sense strand

<400>  1408
gagcagcguc cacucagag                                                    19


<210>  1409
<211>  19
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  19 mer sense strand

<400>  1409
agcagcgucc acucagagc                                                    19


<210>  1410
<211>  19
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  19 mer sense strand

<400>  1410
gcagcgucca cucagagca                                                    19


<210>  1411
<211>  19
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  19 mer sense strand

<400>  1411
cagcguccac ucagagcaa                                                    19


<210>  1412
<211>  19
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  19 mer sense strand

<400>  1412
agcguccacu cagagcaag                                                    19


<210>  1413
<211>  19
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  19 mer sense strand

<400>  1413
gcguccacuc agagcaagu                                                    19


<210>  1414
<211>  19
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  19 mer sense strand

<400>  1414
cguccacuca gagcaagug                                                    19


<210>  1415
<211>  19
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  19 mer sense strand

<400>  1415
guccacucag agcaagugu                                                    19


<210>  1416
<211>  19
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  19 mer sense strand

<400>  1416
uccacucaga gcaaguguu                                                    19


<210>  1417
<211>  19
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  19 mer sense strand

<400>  1417
ccacucagag caaguguuu                                                    19


<210>  1418
<211>  19
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  19 mer sense strand

<400>  1418
acucagagca aguguuugc                                                    19


<210>  1419
<211>  19
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  19 mer sense strand

<400>  1419
cucagagcaa guguuugca                                                    19


<210>  1420
<211>  19
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  19 mer sense strand

<400>  1420
ucagagcaag uguuugcac                                                    19


<210>  1421
<211>  19
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  19 mer sense strand

<400>  1421
cagagcaagu guuugcacu                                                    19


<210>  1422
<211>  19
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  19 mer sense strand

<400>  1422
agagcaagug uuugcacug                                                    19


<210>  1423
<211>  19
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  19 mer sense strand

<400>  1423
gagcaagugu uugcacugc                                                    19


<210>  1424
<211>  19
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  19 mer sense strand

<400>  1424
agcaaguguu ugcacugcg                                                    19


<210>  1425
<211>  19
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  19 mer sense strand

<400>  1425
gcaaguguuu gcacugcgu                                                    19


<210>  1426
<211>  19
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  19 mer sense strand

<400>  1426
caaguguuug cacugcguc                                                    19


<210>  1427
<211>  19
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  19 mer sense strand

<400>  1427
aaguguuugc acugcgucu                                                    19


<210>  1428
<211>  19
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  19 mer sense strand

<400>  1428
aguguuugca cugcgucug                                                    19


<210>  1429
<211>  19
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  19 mer sense strand

<400>  1429
guguuugcac ugcgucugc                                                    19


<210>  1430
<211>  19
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  19 mer sense strand

<400>  1430
uguuugcacu gcgucugca                                                    19


<210>  1431
<211>  19
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  19 mer sense strand

<400>  1431
guuugcacug cgucugcag                                                    19


<210>  1432
<211>  19
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  19 mer sense strand

<400>  1432
uuugcacugc gucugcagg                                                    19


<210>  1433
<211>  19
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  19 mer sense strand

<400>  1433
uugcacugcg ucugcagga                                                    19


<210>  1434
<211>  19
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  19 mer sense strand

<400>  1434
ugcacugcgu cugcaggac                                                    19


<210>  1435
<211>  19
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  19 mer sense strand

<400>  1435
gcacugcguc ugcaggaca                                                    19


<210>  1436
<211>  19
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  19 mer sense strand

<400>  1436
cacugcgucu gcaggacaa                                                    19


<210>  1437
<211>  19
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  19 mer sense strand

<400>  1437
acugcgucug caggacaaa                                                    19


<210>  1438
<211>  19
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  19 mer sense strand

<400>  1438
cugcgucugc aggacaaaa                                                    19


<210>  1439
<211>  19
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  19 mer sense strand

<400>  1439
ugcgucugca ggacaaaaa                                                    19


<210>  1440
<211>  19
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  19 mer sense strand

<400>  1440
gcgucugcag gacaaaaag                                                    19


<210>  1441
<211>  19
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  19 mer sense strand

<400>  1441
cgucugcagg acaaaaagc                                                    19


<210>  1442
<211>  19
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  19 mer sense strand

<400>  1442
gucugcagga caaaaagcu                                                    19


<210>  1443
<211>  19
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  19 mer sense strand

<400>  1443
ucugcaggac aaaaagcuc                                                    19


<210>  1444
<211>  19
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  19 mer sense strand

<400>  1444
cugcaggaca aaaagcucc                                                    19


<210>  1445
<211>  19
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  19 mer sense strand

<400>  1445
gcaggacaaa aagcuccca                                                    19


<210>  1446
<211>  19
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  19 mer sense strand

<400>  1446
caggacaaaa agcucccac                                                    19


<210>  1447
<211>  19
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  19 mer sense strand

<400>  1447
aggacaaaaa gcucccacc                                                    19


<210>  1448
<211>  19
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  19 mer sense strand

<400>  1448
ggacaaaaag cucccaccg                                                    19


<210>  1449
<211>  19
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  19 mer sense strand

<400>  1449
acaaaaagcu cccaccgcu                                                    19


<210>  1450
<211>  19
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  19 mer sense strand

<400>  1450
caaaaagcuc ccaccgcug                                                    19


<210>  1451
<211>  19
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  19 mer sense strand

<400>  1451
aaaaagcucc caccgcugc                                                    19


<210>  1452
<211>  19
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  19 mer sense strand

<400>  1452
aaaagcuccc accgcugcu                                                    19


<210>  1453
<211>  19
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  19 mer sense strand

<400>  1453
aaagcuccca ccgcugcuc                                                    19


<210>  1454
<211>  19
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  19 mer sense strand

<400>  1454
aagcucccac cgcugcucu                                                    19


<210>  1455
<211>  19
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  19 mer sense strand

<400>  1455
agcucccacc gcugcucuc                                                    19


<210>  1456
<211>  19
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  19 mer sense strand

<400>  1456
gcucccaccg cugcucucu                                                    19


<210>  1457
<211>  19
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  19 mer sense strand

<400>  1457
ucccaccgcu gcucucuga                                                    19


<210>  1458
<211>  19
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  19 mer sense strand

<400>  1458
ccaccgcugc ucucugaga                                                    19


<210>  1459
<211>  19
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  19 mer sense strand

<400>  1459
caccgcugcu cucugagau                                                    19


<210>  1460
<211>  19
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  19 mer sense strand

<400>  1460
ccgcugcucu cugagaucu                                                    19


<210>  1461
<211>  19
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  19 mer sense strand

<400>  1461
cgcugcucuc ugagaucug                                                    19


<210>  1462
<211>  19
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  19 mer sense strand

<400>  1462
gcugcucucu gagaucugg                                                    19


<210>  1463
<211>  19
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  19 mer sense strand

<400>  1463
gcucucugag aucugggau                                                    19


<210>  1464
<211>  19
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  19 mer sense strand

<400>  1464
ucucugagau cugggaugu                                                    19


<210>  1465
<211>  19
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  19 mer sense strand

<400>  1465
cucugagauc ugggaugug                                                    19


<210>  1466
<211>  19
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  19 mer sense strand

<400>  1466
ucugagaucu gggaugugc                                                    19


<210>  1467
<211>  19
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  19 mer sense strand

<400>  1467
cugagaucug ggaugugca                                                    19


<210>  1468
<211>  19
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  19 mer sense strand

<400>  1468
ugagaucugg gaugugcac                                                    19


<210>  1469
<211>  19
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  19 mer sense strand

<400>  1469
gagaucuggg augugcacg                                                    19


<210>  1470
<211>  19
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  19 mer sense strand

<400>  1470
agaucuggga ugugcacga                                                    19


<210>  1471
<211>  19
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  19 mer sense strand

<400>  1471
gaucugggau gugcacgaa                                                    19


<210>  1472
<211>  19
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  19 mer sense strand

<400>  1472
aucugggaug ugcacgaau                                                    19


<210>  1473
<211>  19
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  19 mer sense strand

<400>  1473
ucugggaugu gcacgaaug                                                    19


<210>  1474
<211>  19
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  19 mer sense strand

<400>  1474
cugggaugug cacgaauga                                                    19


<210>  1475
<211>  19
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  19 mer sense strand

<400>  1475
ugggaugugc acgaaugac                                                    19


<210>  1476
<211>  19
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  19 mer sense strand

<400>  1476
gggaugugca cgaaugacu                                                    19


<210>  1477
<211>  19
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  19 mer sense strand

<400>  1477
ggaugugcac gaaugacug                                                    19


<210>  1478
<211>  19
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  19 mer sense strand

<400>  1478
gaugugcacg aaugacugu                                                    19


<210>  1479
<211>  19
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  19 mer sense strand

<400>  1479
ugguggcugc cuccuagaa                                                    19


<210>  1480
<211>  19
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  19 mer sense strand

<400>  1480
gguggcugcc uccuagaag                                                    19


<210>  1481
<211>  19
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  19 mer sense strand

<400>  1481
guggcugccu ccuagaagu                                                    19


<210>  1482
<211>  19
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  19 mer sense strand

<400>  1482
uggcugccuc cuagaagug                                                    19


<210>  1483
<211>  19
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  19 mer sense strand

<400>  1483
ggcugccucc uagaagugg                                                    19


<210>  1484
<211>  19
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  19 mer sense strand

<400>  1484
gcugccuccu agaagugga                                                    19


<210>  1485
<211>  19
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  19 mer sense strand

<400>  1485
cugccuccua gaaguggaa                                                    19


<210>  1486
<211>  19
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  19 mer sense strand

<400>  1486
ugccuccuag aaguggaac                                                    19


<210>  1487
<211>  19
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  19 mer sense strand

<400>  1487
gccuccuaga aguggaaca                                                    19


<210>  1488
<211>  19
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  19 mer sense strand

<400>  1488
ccuccuagaa guggaacag                                                    19


<210>  1489
<211>  19
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  19 mer sense strand

<400>  1489
cuccuagaag uggaacaga                                                    19


<210>  1490
<211>  19
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  19 mer sense strand

<400>  1490
uccuagaagu ggaacagac                                                    19


<210>  1491
<211>  19
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  19 mer sense strand

<400>  1491
ccuagaagug gaacagacu                                                    19


<210>  1492
<211>  19
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  19 mer sense strand

<400>  1492
cuagaagugg aacagacug                                                    19


<210>  1493
<211>  19
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  19 mer sense strand

<400>  1493
agaaguggaa cagacugag                                                    19


<210>  1494
<211>  19
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  19 mer sense strand

<400>  1494
ggaacagacu gagaagggc                                                    19


<210>  1495
<211>  19
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  19 mer sense strand

<400>  1495
aacagacuga gaagggcaa                                                    19


<210>  1496
<211>  19
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  19 mer sense strand

<400>  1496
acagacugag aagggcaaa                                                    19


<210>  1497
<211>  19
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  19 mer sense strand

<400>  1497
cagacugaga agggcaaac                                                    19


<210>  1498
<211>  19
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  19 mer sense strand

<400>  1498
agacugagaa gggcaaaca                                                    19


<210>  1499
<211>  19
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  19 mer sense strand

<400>  1499
gacugagaag ggcaaacau                                                    19


<210>  1500
<211>  19
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  19 mer sense strand

<400>  1500
acugagaagg gcaaacauu                                                    19


<210>  1501
<211>  19
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  19 mer sense strand

<400>  1501
cugagaaggg caaacauuc                                                    19


<210>  1502
<211>  19
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  19 mer sense strand

<400>  1502
ugagaagggc aaacauucc                                                    19


<210>  1503
<211>  19
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  19 mer sense strand

<400>  1503
gagaagggca aacauuccu                                                    19


<210>  1504
<211>  19
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  19 mer sense strand

<400>  1504
cccguggcau uaaaagaga                                                    19


<210>  1505
<211>  19
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  19 mer sense strand

<400>  1505
ccguggcauu aaaagagag                                                    19


<210>  1506
<211>  19
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  19 mer sense strand

<400>  1506
cguggcauua aaagagagu                                                    19


<210>  1507
<211>  19
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  19 mer sense strand

<400>  1507
guggcauuaa aagagaguc                                                    19


<210>  1508
<211>  19
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  19 mer sense strand

<400>  1508
uggcauuaaa agagaguca                                                    19


<210>  1509
<211>  19
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  19 mer sense strand

<400>  1509
cucaaggauu ucaguuaua                                                    19


<210>  1510
<211>  19
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  19 mer sense strand

<400>  1510
ucaaggauuu caguuauaa                                                    19


<210>  1511
<211>  19
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  19 mer sense strand

<400>  1511
augugcacga augacuguu                                                    19


<210>  1512
<211>  19
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  19 mer antisense strand

<400>  1512
uauaacugaa auccuugag                                                    19


<210>  1513
<211>  19
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  19 mer antisense strand

<400>  1513
uuauaacuga aauccuuga                                                    19


<210>  1514
<211>  19
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  19 mer antisense strand

<400>  1514
gcucugagug gacgcugcu                                                    19


<210>  1515
<211>  19
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  19 mer antisense strand

<400>  1515
aacagucauu cgugcacau                                                    19


<210>  1516
<211>  5874
<212>  DNA
<213>  Homo sapiens

<400>  1516
atggaattcc ccattggatc cctcgaaact aacaacttcc gtcgctttac tccggagtca       60

ctggtggaga tagagaagca aattgctgcc aagcagggaa caaagaaagc cagagagaag      120

catagggagc agaaggacca agaagagaag cctcggcccc agctggactt gaaagcctgc      180

aaccagctgc ccaagttcta tggtgagctc ccagcagaac tgatcgggga gcccctggag      240

gatctagatc cgttctacag cacacaccgg acatttatgg tgctgaacaa agggaggacc      300

atttcccggt ttagtgccac tcgggccctg tggctattca gtcctttcaa cctgatcaga      360

agaacggcca tcaaagtgtc tgtccactcg tggttcagtt tatttattac ggtcactatt      420

ttggttaatt gtgtgtgcat gacccgaact gaccttccag agaaaattga atatgtcttc      480

actgtcattt acacctttga agccttgata aagatactgg caagaggatt ttgtctaaat      540

gagttcacgt acctgagaga tccttggaac tggctggatt ttagcgtcat taccctggca      600

tatgttggca cagcaataga tctccgtggg atctcaggcc tgcggacatt cagagttctt      660

agagcattaa aaacagtttc tgtgatccca ggcctgaagg tcattgtggg ggccctgatt      720

cactcagtga agaaactggc tgatgtgacc atcctcacca tcttctgcct aagtgttttt      780

gccttggtgg ggctgcaact cttcaagggc aacctcaaaa ataaatgtgt caagaatgac      840

atggctgtca atgagacaac caactactca tctcacagaa aaccagatat ctacataaat      900

aagcgaggca cttctgaccc cttactgtgt ggcaatggat ctgactcagg ccactgccct      960

gatggttata tctgccttaa aacttctgac aacccggatt ttaactacac cagctttgat     1020

tcctttgctt gggctttcct ctcactgttc cgcctcatga cacaggattc ctgggaacgc     1080

ctctaccagc agaccctgag gacttctggg aaaatctata tgatcttttt tgtgctcgta     1140

atcttcctgg gatctttcta cctggtcaac ttgatcttgg ctgtagtcac catggcgtat     1200

gaggagcaga accaggcaac cactgatgaa attgaagcaa aggagaagaa gttccaggag     1260

gccctcgaga tgctccggaa ggagcaggag gtgctagcag cactagggat tgacacaacc     1320

tctctccact cccacaatgg atcaccttta acctccaaaa atgccagtga gagaaggcat     1380

agaataaagc caagagtgtc agagggctcc acagaagaca acaaatcacc ccgctctgat     1440

ccttacaacc agcgcaggat gtcttttcta ggcctcgcct ctggaaaacg ccgggctagt     1500

catggcagtg tgttccattt ccggtcccct ggccgagata tctcactccc tgagggagtc     1560

acagatgatg gagtctttcc tggagaccac gaaagccatc ggggctctct gctgctgggt     1620

gggggtgctg gccagcaagg ccccctccct agaagccctc ttcctcaacc cagcaaccct     1680

gactccaggc atggagaaga tgaacaccaa ccgccgccca ctagtgagct tgcccctgga     1740

gctgtcgatg tctcggcatt cgatgcagga caaaagaaga ctttcttgtc agcagaatac     1800

ttagatgaac ctttccgggc ccaaagggca atgagtgttg tcagtatcat aacctccgtc     1860

cttgaggaac tcgaggagtc tgaacagaag tgcccaccct gcttgaccag cttgtctcag     1920

aagtatctga tctgggattg ctgccccatg tgggtgaagc tcaagacaat tctctttggg     1980

cttgtgacgg atccctttgc agagctcacc atcaccttgt gcatcgtggt gaacaccatc     2040

ttcatggcca tggagcacca tggcatgagc cctaccttcg aagccatgct ccagataggc     2100

aacatcgtct ttaccatatt ttttactgct gaaatggtct tcaaaatcat tgccttcgac     2160

ccatactatt atttccagaa gaagtggaat atctttgact gcatcatcgt cactgtgagt     2220

ctgctagagc tgggcgtggc caagaaggga agcctgtctg tgctgcggag cttccgcttg     2280

ctgcgcgtat tcaagctggc caaatcctgg cccaccttaa acacactcat caagatcatc     2340

ggaaactcag tgggggcact ggggaacctc accatcatcc tggccatcat tgtctttgtc     2400

tttgctctgg ttggcaagca gctcctaggg gaaaactacc gtaacaaccg aaaaaatatc     2460

tccgcgcccc atgaagactg gccccgctgg cacatgcacg acttcttcca ctctttcctc     2520

attgtcttcc gtatcctctg tggagagtgg attgagaaca tgtgggcctg catggaagtt     2580

ggccaaaaat ccatatgcct catccttttc ttgacggtga tggtgctagg gaacctggtg     2640

gtgcttaacc tgttcatcgc cctgctattg aactctttca gtgctgacaa cctcacagcc     2700

ccggaggacg atggggaggt gaacaacctg caggtggccc tggcacggat ccaggtcttt     2760

ggccatcgta ccaaacaggc tctttgcagc ttcttcagca ggtcctgccc attcccccag     2820

cccaaggcag agcctgagct ggtggtgaaa ctcccactct ccagctccaa ggctgagaac     2880

cacattgctg ccaacactgc cagggggagc tctggagggc tccaagctcc cagaggcccc     2940

agggatgagc acagtgactt catcgctaat ccgactgtgt gggtctctgt gcccattgct     3000

gagggtgaat ctgatcttga tgacttggag gatgatggtg gggaagatgc tcagagcttc     3060

cagcaggaag tgatccccaa aggacagcag gagcagctgc agcaagtcga gaggtgtggg     3120

gaccacctga cacccaggag cccaggcact ggaacatctt ctgaggacct ggctccatcc     3180

ctgggtgaga cgtggaaaga tgagtctgtt cctcaggtcc ctgctgaggg agtggacgac     3240

acaagctcct ctgagggcag cacggtggac tgcctagatc ctgaggaaat cctgaggaag     3300

atccctgagc tggcagatga cctggaagaa ccagatgact gcttcacaga aggatgcatt     3360

cgccactgtc cctgctgcaa actggatacc accaagagtc catgggatgt gggctggcag     3420

gtgcgcaaga cttgctaccg tatcgtggag cacagctggt ttgagagctt catcatcttc     3480

atgatcctgc tcagcagtgg atctctggcc tttgaagact attacctgga ccagaagccc     3540

acggtgaaag ctttgctgga gtacactgac agggtcttca cctttatctt tgtgttcgag     3600

atgctgctta agtgggtggc ctatggcttc aaaaagtact tcaccaatgc ctggtgctgg     3660

ctggacttcc tcattgtgaa tatctcactg ataagtctca cagcgaagat tctggaatat     3720

tctgaagtgg ctcccatcaa agcccttcga acccttcgcg ctctgcggcc actgcgggct     3780

ctttctcgat ttgaaggcat gcgggtggtg gtggatgccc tggtgggcgc catcccatcc     3840

atcatgaatg tcctcctcgt ctgcctcatc ttctggctca tcttcagcat catgggtgtg     3900

aacctcttcg cagggaagtt ttggaggtgc atcaactata ccgatggaga gttttccctt     3960

gtacctttgt cgattgtgaa taacaagtct gactgcaaga ttcaaaactc cactggcagc     4020

ttcttctggg tcaatgtgaa agtcaacttt gataatgttg caatgggtta ccttgcactt     4080

ctgcaggtgg caacctttaa aggctggatg gacattatgt atgcagctgt tgattcccgg     4140

gaggtcaaca tgcaacccaa gtgggaggac aacgtgtaca tgtatttgta ctttgtcatc     4200

ttcatcattt ttggaggctt cttcacactg aatctctttg ttggggtcat aattgacaac     4260

ttcaatcaac agaaaaaaaa gttagggggc caggacatct tcatgacaga ggagcagaag     4320

aaatactaca atgccatgaa gaagttgggc tccaagaagc cccagaagcc catcccacgg     4380

cccctgaaca agttccaggg ttttgtcttt gacatcgtga ccagacaagc ttttgacatc     4440

accatcatgg tcctcatctg cctcaacatg atcaccatga tggtggagac tgatgaccaa     4500

agtgaagaaa agacgaaaat tctgggcaaa atcaaccagt tctttgtggc cgtcttcaca     4560

ggcgaatgtg tcatgaagat gttcgctttg aggcagtact acttcacaaa tggctggaat     4620

gtgtttgact tcattgtggt ggttctctcc attgcgagcc tgattttttc tgcaattctt     4680

aagtcacttc aaagttactt ctccccaacg ctcttcagag tcatccgcct ggcccgaatt     4740

ggccgcatcc tcagactgat ccgagcggcc aaggggatcc gcacactgct ctttgccctc     4800

atgatgtccc tgcctgccct cttcaacatc gggctgttgc tattccttgt catgttcatc     4860

tactctatct tcggtatgtc cagctttccc catgtgaggt gggaggctgg catcgacgac     4920

atgttcaact tccagacctt cgccaacagc atgctgtgcc tcttccagat taccacgtcg     4980

gccggctggg atggcctcct cagccccatc ctcaacacag ggccccccta ctgtgacccc     5040

aatctgccca acagcaatgg caccagaggg gactgtggga gcccagccgt aggcatcatc     5100

ttcttcacca cctacatcat catctccttc ctcatcgtgg tcaacatgta cattgcagtg     5160

attctggaga acttcaatgt ggccacggag gagagcactg agcccctgag tgaggacgac     5220

tttgacatgt tctatgagac ctgggagaag tttgacccag aggccactca gtttattacc     5280

ttttctgctc tctcggactt tgcagacact ctctctggtc ccctgagaat cccaaaaccc     5340

aatcgaaata tactgatcca gatggacctg cctttggtcc ctggagataa gatccactgc     5400

ttggacatcc tttttgcttt caccaagaat gtcctaggag aatccgggga gttggattct     5460

ctgaaggcaa atatggagga gaagtttatg gcaactaatc tttcaaaatc atcctatgaa     5520

ccaatagcaa ccactctccg atggaagcaa gaagacattt cagccactgt cattcaaaag     5580

gcctatcgga gctatgtgct gcaccgctcc atggcactct ctaacacccc atgtgtgccc     5640

agagctgagg aggaggctgc atcactccca gatgaaggtt ttgttgcatt cacagcaaat     5700

gaaaattgtg tactcccaga caaatctgaa actgcttctg ccacatcatt cccaccgtcc     5760

tatgagagtg tcactagagg ccttagtgat agagtcaaca tgaggacatc tagctcaata     5820

caaaatgaag atgaagccac cagtatggag ctgattgccc ctgggcccta gtga           5874


<210>  1517
<211>  22
<212>  DNA
<213>  Artificial Sequence

<220>  
<223>  Forward-942

<400>  1517
gtctctgtgc aggagatagt tg                                                22


<210>  1518
<211>  21
<212>  DNA
<213>  Artificial Sequence

<220>  
<223>  Reverse-1399

<400>  1518
ggaggctcac cagtttcatt a                                                 21


<210>  1519
<211>  36
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  36 mer sense strand

<400>  1519
uccucaagga uuucaguuaa gcagccgaaa ggcugc                                 36


<210>  1520
<211>  36
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  36 mer sense strand

<400>  1520
caguuauaac cgggaagaca gcagccgaaa ggcugc                                 36


<210>  1521
<211>  36
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  36 mer sense strand

<400>  1521
uauaaccggg aagacuuuga gcagccgaaa ggcugc                                 36


<210>  1522
<211>  36
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  36 mer sense strand

<400>  1522
caaagcaggg cugcaaguga gcagccgaaa ggcugc                                 36


<210>  1523
<211>  36
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  36 mer sense strand

<400>  1523
ggcugcaagu ggaauucaua gcagccgaaa ggcugc                                 36


<210>  1524
<211>  36
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  36 mer sense strand

<400>  1524
aguggaauuc aucaacccca gcagccgaaa ggcugc                                 36


<210>  1525
<211>  36
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  36 mer sense strand

<400>  1525
auucaucaac cccaucuuca gcagccgaaa ggcugc                                 36


<210>  1526
<211>  36
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  36 mer sense strand

<400>  1526
uucaucaacc ccaucuucga gcagccgaaa ggcugc                                 36


<210>  1527
<211>  36
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  36 mer sense strand

<400>  1527
ugcaugccua cgucuccaua gcagccgaaa ggcugc                                 36


<210>  1528
<211>  36
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  36 mer sense strand

<400>  1528
ugccuacguc uccauccaca gcagccgaaa ggcugc                                 36


<210>  1529
<211>  36
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  36 mer sense strand

<400>  1529
uacgucucca uccaccauca gcagccgaaa ggcugc                                 36


<210>  1530
<211>  36
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  36 mer sense strand

<400>  1530
cgucuccauc caccauccca gcagccgaaa ggcugc                                 36


<210>  1531
<211>  36
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  36 mer sense strand

<400>  1531
auccaccauc cccaugacca gcagccgaaa ggcugc                                 36


<210>  1532
<211>  36
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  36 mer sense strand

<400>  1532
ccgacugaug uucccacgga gcagccgaaa ggcugc                                 36


<210>  1533
<211>  36
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  36 mer sense strand

<400>  1533
cccacggaug cuaaugaaaa gcagccgaaa ggcugc                                 36


<210>  1534
<211>  36
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  36 mer sense strand

<400>  1534
cggaugcuaa ugaaacugga gcagccgaaa ggcugc                                 36


<210>  1535
<211>  36
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  36 mer sense strand

<400>  1535
gaugcuaaug aaacugguga gcagccgaaa ggcugc                                 36


<210>  1536
<211>  36
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  36 mer sense strand

<400>  1536
cuaaugaaac uggugagcca gcagccgaaa ggcugc                                 36


<210>  1537
<211>  36
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  36 mer sense strand

<400>  1537
agcagcgucc acucagagca gcagccgaaa ggcugc                                 36


<210>  1538
<211>  36
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  36 mer sense strand

<400>  1538
cagcguccac ucagagcaaa gcagccgaaa ggcugc                                 36


<210>  1539
<211>  36
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  36 mer sense strand

<400>  1539
agcguccacu cagagcaaga gcagccgaaa ggcugc                                 36


<210>  1540
<211>  36
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  36 mer sense strand

<400>  1540
caaguguuug cacugcguca gcagccgaaa ggcugc                                 36


<210>  1541
<211>  36
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  36 mer sense strand

<400>  1541
aguguuugca cugcgucuga gcagccgaaa ggcugc                                 36


<210>  1542
<211>  36
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  36 mer sense strand

<400>  1542
cugcgucugc aggacaaaaa gcagccgaaa ggcugc                                 36


<210>  1543
<211>  36
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  36 mer sense strand

<400>  1543
caggacaaaa agcucccaca gcagccgaaa ggcugc                                 36


<210>  1544
<211>  36
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  36 mer sense strand

<400>  1544
ucugagaucu gggaugugca gcagccgaaa ggcugc                                 36


<210>  1545
<211>  36
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  36 mer sense strand

<400>  1545
gaucugggau gugcacgaaa gcagccgaaa ggcugc                                 36


<210>  1546
<211>  36
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  36 mer sense strand

<400>  1546
aucugggaug ugcacgaaua gcagccgaaa ggcugc                                 36


<210>  1547
<211>  36
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  36 mer sense strand

<400>  1547
ucugggaugu gcacgaauga gcagccgaaa ggcugc                                 36


<210>  1548
<211>  36
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  36 mer sense strand

<400>  1548
ugccuccuag aaguggaaca gcagccgaaa ggcugc                                 36


<210>  1549
<211>  36
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  36 mer sense strand

<400>  1549
agaaguggaa cagacugaga gcagccgaaa ggcugc                                 36


<210>  1550
<211>  36
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  36 mer sense strand

<400>  1550
acugagaagg gcaaacauua gcagccgaaa ggcugc                                 36


<210>  1551
<211>  36
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  36 mer sense strand

<400>  1551
guggcauuaa aagagaguca gcagccgaaa ggcugc                                 36


<210>  1552
<211>  36
<212>  RNA
<213>  Artificial Sequence

<220>  
<223>  36 mer sense strand

<400>  1552
uggcauuaaa agagagucaa gcagccgaaa ggcugc                                 36


