                         SEQUENCE LISTING

<110>  Navigo Proteins GmbH
 
<120>  FUSION PROTEINS WITH SPECIFITY FOR TYPE II COLLAGEN AND VEGF-A 
       FOR THE TREATMENT OF EYE DISEASES

<130>  NP40

<160>  22    

<170>  PatentIn version 3.5

<210>  1
<211>  58
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Type 2 Collagen binding protein


<220>
<221>  Xaa
<222>  (10)..(10)
<223>  Xaa is selected from S or Q

<220>
<221>  Xaa
<222>  (14)..(14)
<223>  Xaa is selected from S or Q

<220>
<221>  Xaa
<222>  (14)..(14)
<223>  Xaa is selected from S or K

<220>
<221>  Xaa
<222>  (28)..(28)
<223>  Xaa is selected from H or N

<220>
<221>  Xaa
<222>  (32)..(32)
<223>  Xaa is selected from R or Q

<220>
<221>  Xaa
<222>  (35)..(35)
<223>  Xaa is selected from S or R

<220>
<221>  Xaa
<222>  (42)..(42)
<223>  Xaa is selected from T or P

<220>
<221>  Xaa
<222>  (43)..(43)
<223>  Xaa is selected from H or T

<220>
<221>  Xaa
<222>  (44)..(44)
<223>  Xaa is selected from I or V

<220>
<221>  Xaa
<222>  (46)..(46)
<223>  Xaa is selected from G or T

<220>
<221>  Xaa
<222>  (47)..(47)
<223>  Xaa is selected from Q or T

<220>
<221>  Xaa
<222>  (50)..(50)
<223>  Xaa is selected from Q or H

<220>
<221>  Xaa
<222>  (54)..(54)
<223>  Xaa is selected from S or D

<400>  1

Ile Ala Ala Lys Phe Asp Glu Ala Gln Xaa Ala Ala Asp Xaa Glu Ile 
1               5                   10                  15      


Leu His Leu Pro Asn Leu Thr Glu Gln Gln Arg Xaa Tyr Phe Arg Xaa 
            20                  25                  30          


Trp Leu Xaa Asp Asp Pro Ser Val Ser Xaa Xaa Xaa Leu Xaa Xaa Ala 
        35                  40                  45              


Gln Xaa Leu Asn Asp Xaa Gln Ala Pro Lys 
    50                  55              


<210>  2
<211>  58
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Type II collagen binding protein

<400>  2

Ile Ala Ala Lys Phe Asp Glu Ala Gln Ser Ala Ala Asp Ser Glu Ile 
1               5                   10                  15      


Leu His Leu Pro Asn Leu Thr Glu Gln Gln Arg His Tyr Phe Arg Arg 
            20                  25                  30          


Trp Leu Ser Asp Asp Pro Ser Val Ser Thr His Ile Leu Thr Gln Ala 
        35                  40                  45              


Gln His Leu Asn Asp Asp Gln Ala Pro Lys 
    50                  55              


<210>  3
<211>  58
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Type II collagen binding protein

<400>  3

Ile Ala Ala Lys Phe Asp Glu Ala Gln Gln Ala Ala Asp Lys Glu Ile 
1               5                   10                  15      


Leu His Leu Pro Asn Leu Thr Glu Gln Gln Arg Asn Tyr Phe Arg Gln 
            20                  25                  30          


Trp Leu Arg Asp Asp Pro Ser Val Ser Pro Thr Val Leu Gly Thr Ala 
        35                  40                  45              


Gln Gln Leu Asn Asp Ser Gln Ala Pro Lys 
    50                  55              


<210>  4
<211>  116
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Type 2 Collagen binding protein (dimer of SEQ ID NO: 2)

<400>  4

Ile Ala Ala Lys Phe Asp Glu Ala Gln Ser Ala Ala Asp Ser Glu Ile 
1               5                   10                  15      


Leu His Leu Pro Asn Leu Thr Glu Gln Gln Arg His Tyr Phe Arg Arg 
            20                  25                  30          


Trp Leu Ser Asp Asp Pro Ser Val Ser Thr His Ile Leu Thr Gln Ala 
        35                  40                  45              


Gln His Leu Asn Asp Asp Gln Ala Pro Lys Ile Ala Ala Lys Phe Asp 
    50                  55                  60                  


Glu Ala Gln Ser Ala Ala Asp Ser Glu Ile Leu His Leu Pro Asn Leu 
65                  70                  75                  80  


Thr Glu Gln Gln Arg His Tyr Phe Arg Arg Trp Leu Ser Asp Asp Pro 
                85                  90                  95      


Ser Val Ser Thr His Ile Leu Thr Gln Ala Gln His Leu Asn Asp Asp 
            100                 105                 110         


Gln Ala Pro Lys 
        115     


<210>  5
<211>  116
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Type II collagen binding protein (dimer of SEQ ID NO: 3)

<400>  5

Ile Ala Ala Lys Phe Asp Glu Ala Gln Gln Ala Ala Asp Lys Glu Ile 
1               5                   10                  15      


Leu His Leu Pro Asn Leu Thr Glu Gln Gln Arg Asn Tyr Phe Arg Gln 
            20                  25                  30          


Trp Leu Arg Asp Asp Pro Ser Val Ser Pro Thr Val Leu Gly Thr Ala 
        35                  40                  45              


Gln Gln Leu Asn Asp Ser Gln Ala Pro Lys Ile Ala Ala Lys Phe Asp 
    50                  55                  60                  


Glu Ala Gln Gln Ala Ala Asp Lys Glu Ile Leu His Leu Pro Asn Leu 
65                  70                  75                  80  


Thr Glu Gln Gln Arg Asn Tyr Phe Arg Gln Trp Leu Arg Asp Asp Pro 
                85                  90                  95      


Ser Val Ser Pro Thr Val Leu Gly Thr Ala Gln Gln Leu Asn Asp Ser 
            100                 105                 110         


Gln Ala Pro Lys 
        115     


<210>  6
<211>  562
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  fusion protein 213182

<400>  6

Ser Asp Thr Gly Arg Pro Phe Val Glu Met Tyr Ser Glu Ile Pro Glu 
1               5                   10                  15      


Ile Ile His Met Thr Glu Gly Arg Glu Leu Val Ile Pro Cys Arg Val 
            20                  25                  30          


Thr Ser Pro Asn Ile Thr Val Thr Leu Lys Lys Phe Pro Leu Asp Thr 
        35                  40                  45              


Leu Ile Pro Asp Gly Lys Arg Ile Ile Trp Asp Ser Arg Lys Gly Phe 
    50                  55                  60                  


Ile Ile Ser Asn Ala Thr Tyr Lys Glu Ile Gly Leu Leu Thr Cys Glu 
65                  70                  75                  80  


Ala Thr Val Asn Gly His Leu Tyr Lys Thr Asn Tyr Leu Thr His Arg 
                85                  90                  95      


Gln Thr Asn Thr Ile Ile Asp Val Val Leu Ser Pro Ser His Gly Ile 
            100                 105                 110         


Glu Leu Ser Val Gly Glu Lys Leu Val Leu Asn Cys Thr Ala Arg Thr 
        115                 120                 125             


Glu Leu Asn Val Gly Ile Asp Phe Asn Trp Glu Tyr Pro Ser Ser Lys 
    130                 135                 140                 


His Gln His Lys Lys Leu Val Asn Arg Asp Leu Lys Thr Gln Ser Gly 
145                 150                 155                 160 


Ser Glu Met Lys Lys Phe Leu Ser Thr Leu Thr Ile Asp Gly Val Thr 
                165                 170                 175     


Arg Ser Asp Gln Gly Leu Tyr Thr Cys Ala Ala Ser Ser Gly Leu Met 
            180                 185                 190         


Thr Lys Lys Asn Ser Thr Phe Val Arg Val His Glu Lys Asp Lys Thr 
        195                 200                 205             


His Thr Cys Pro Pro Cys Pro Ala Pro Glu Leu Leu Gly Gly Pro Ser 
    210                 215                 220                 


Val Phe Leu Phe Pro Pro Lys Pro Lys Asp Thr Leu Met Ile Ser Arg 
225                 230                 235                 240 


Thr Pro Glu Val Thr Cys Val Val Val Asp Val Ser His Glu Asp Pro 
                245                 250                 255     


Glu Val Lys Phe Asn Trp Tyr Val Asp Gly Val Glu Val His Asn Ala 
            260                 265                 270         


Lys Thr Lys Pro Arg Glu Glu Gln Tyr Asn Ser Thr Tyr Arg Val Val 
        275                 280                 285             


Ser Val Leu Thr Val Leu His Gln Asp Trp Leu Asn Gly Lys Glu Tyr 
    290                 295                 300                 


Lys Cys Lys Val Ser Asn Lys Ala Leu Pro Ala Pro Ile Glu Lys Thr 
305                 310                 315                 320 


Ile Ser Lys Ala Lys Gly Gln Pro Arg Glu Pro Gln Val Tyr Thr Leu 
                325                 330                 335     


Pro Pro Ser Arg Asp Glu Leu Thr Lys Asn Gln Val Ser Leu Thr Cys 
            340                 345                 350         


Leu Val Lys Gly Phe Tyr Pro Ser Asp Ile Ala Val Glu Trp Glu Ser 
        355                 360                 365             


Asn Gly Gln Pro Glu Asn Asn Tyr Lys Thr Thr Pro Pro Val Leu Asp 
    370                 375                 380                 


Ser Asp Gly Ser Phe Phe Leu Tyr Ser Lys Leu Thr Val Asp Lys Ser 
385                 390                 395                 400 


Arg Trp Gln Gln Gly Asn Val Phe Ser Cys Ser Val Met His Glu Ala 
                405                 410                 415     


Leu His Asn His Tyr Thr Gln Lys Ser Leu Ser Leu Ser Pro Gly Gly 
            420                 425                 430         


Gly Gly Gly Ser Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser Ile Ala 
        435                 440                 445             


Ala Lys Phe Asp Glu Ala Gln Ser Ala Ala Asp Ser Glu Ile Leu His 
    450                 455                 460                 


Leu Pro Asn Leu Thr Glu Gln Gln Arg His Tyr Phe Arg Arg Trp Leu 
465                 470                 475                 480 


Ser Asp Asp Pro Ser Val Ser Thr His Ile Leu Thr Gln Ala Gln His 
                485                 490                 495     


Leu Asn Asp Asp Gln Ala Pro Lys Ile Ala Ala Lys Phe Asp Glu Ala 
            500                 505                 510         


Gln Ser Ala Ala Asp Ser Glu Ile Leu His Leu Pro Asn Leu Thr Glu 
        515                 520                 525             


Gln Gln Arg His Tyr Phe Arg Arg Trp Leu Ser Asp Asp Pro Ser Val 
    530                 535                 540                 


Ser Thr His Ile Leu Thr Gln Ala Gln His Leu Asn Asp Asp Gln Ala 
545                 550                 555                 560 


Pro Lys 
        


<210>  7
<211>  592
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  fusion protein 213340

<400>  7

Ser Asp Thr Gly Arg Pro Phe Val Glu Met Tyr Ser Glu Ile Pro Glu 
1               5                   10                  15      


Ile Ile His Met Thr Glu Gly Arg Glu Leu Val Ile Pro Cys Arg Val 
            20                  25                  30          


Thr Ser Pro Asn Ile Thr Val Thr Leu Lys Lys Phe Pro Leu Asp Thr 
        35                  40                  45              


Leu Ile Pro Asp Gly Lys Arg Ile Ile Trp Asp Ser Arg Lys Gly Phe 
    50                  55                  60                  


Ile Ile Ser Asn Ala Thr Tyr Lys Glu Ile Gly Leu Leu Thr Cys Glu 
65                  70                  75                  80  


Ala Thr Val Asn Gly His Leu Tyr Lys Thr Asn Tyr Leu Thr His Arg 
                85                  90                  95      


Gln Thr Asn Thr Ile Ile Asp Val Val Leu Ser Pro Ser His Gly Ile 
            100                 105                 110         


Glu Leu Ser Val Gly Glu Lys Leu Val Leu Asn Cys Thr Ala Arg Thr 
        115                 120                 125             


Glu Leu Asn Val Gly Ile Asp Phe Asn Trp Glu Tyr Pro Ser Ser Lys 
    130                 135                 140                 


His Gln His Lys Lys Leu Val Asn Arg Asp Leu Lys Thr Gln Ser Gly 
145                 150                 155                 160 


Ser Glu Met Lys Lys Phe Leu Ser Thr Leu Thr Ile Asp Gly Val Thr 
                165                 170                 175     


Arg Ser Asp Gln Gly Leu Tyr Thr Cys Ala Ala Ser Ser Gly Leu Met 
            180                 185                 190         


Thr Lys Lys Asn Ser Thr Phe Val Arg Val His Glu Lys Asp Lys Thr 
        195                 200                 205             


His Thr Cys Pro Pro Cys Pro Ala Pro Glu Leu Leu Gly Gly Pro Ser 
    210                 215                 220                 


Val Phe Leu Phe Pro Pro Lys Pro Lys Asp Thr Leu Met Ile Ser Arg 
225                 230                 235                 240 


Thr Pro Glu Val Thr Cys Val Val Val Asp Val Ser His Glu Asp Pro 
                245                 250                 255     


Glu Val Lys Phe Asn Trp Tyr Val Asp Gly Val Glu Val His Asn Ala 
            260                 265                 270         


Lys Thr Lys Pro Arg Glu Glu Gln Tyr Asn Ser Thr Tyr Arg Val Val 
        275                 280                 285             


Ser Val Leu Thr Val Leu His Gln Asp Trp Leu Asn Gly Lys Glu Tyr 
    290                 295                 300                 


Lys Cys Lys Val Ser Asn Lys Ala Leu Pro Ala Pro Ile Glu Lys Thr 
305                 310                 315                 320 


Ile Ser Lys Ala Lys Gly Gln Pro Arg Glu Pro Gln Val Tyr Thr Leu 
                325                 330                 335     


Pro Pro Ser Arg Asp Glu Leu Thr Lys Asn Gln Val Ser Leu Thr Cys 
            340                 345                 350         


Leu Val Lys Gly Phe Tyr Pro Ser Asp Ile Ala Val Glu Trp Glu Ser 
        355                 360                 365             


Asn Gly Gln Pro Glu Asn Asn Tyr Lys Thr Thr Pro Pro Val Leu Asp 
    370                 375                 380                 


Ser Asp Gly Ser Phe Phe Leu Tyr Ser Lys Leu Thr Val Asp Lys Ser 
385                 390                 395                 400 


Arg Trp Gln Gln Gly Asn Val Phe Ser Cys Ser Val Met His Glu Ala 
                405                 410                 415     


Leu His Asn His Tyr Thr Gln Lys Ser Leu Ser Leu Ser Pro Gly Gly 
            420                 425                 430         


Gly Gly Gly Ser Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser Ile Ala 
        435                 440                 445             


Ala Lys Phe Asp Glu Ala Gln Ser Ala Ala Asp Ser Glu Ile Leu His 
    450                 455                 460                 


Leu Pro Asn Leu Thr Glu Gln Gln Arg His Tyr Phe Arg Arg Trp Leu 
465                 470                 475                 480 


Ser Asp Asp Pro Ser Val Ser Thr His Ile Leu Thr Gln Ala Gln His 
                485                 490                 495     


Leu Asn Asp Asp Gln Ala Pro Lys Gly Gly Gly Gly Ser Gly Gly Gly 
            500                 505                 510         


Gly Ser Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser Ile Ala Ala Lys 
        515                 520                 525             


Phe Asp Glu Ala Gln Ser Ala Ala Asp Ser Glu Ile Leu His Leu Pro 
    530                 535                 540                 


Asn Leu Thr Glu Gln Gln Arg His Tyr Phe Arg Arg Trp Leu Ser Asp 
545                 550                 555                 560 


Asp Pro Ser Val Ser Thr His Ile Leu Thr Gln Ala Gln His Leu Asn 
                565                 570                 575     


Asp Asp Gln Ala Pro Lys Ser Ala Trp Ser His Pro Gln Phe Glu Lys 
            580                 585                 590         


<210>  8
<211>  678
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  fusion protein 213184

<400>  8

Ser Asp Thr Gly Arg Pro Phe Val Glu Met Tyr Ser Glu Ile Pro Glu 
1               5                   10                  15      


Ile Ile His Met Thr Glu Gly Arg Glu Leu Val Ile Pro Cys Arg Val 
            20                  25                  30          


Thr Ser Pro Asn Ile Thr Val Thr Leu Lys Lys Phe Pro Leu Asp Thr 
        35                  40                  45              


Leu Ile Pro Asp Gly Lys Arg Ile Ile Trp Asp Ser Arg Lys Gly Phe 
    50                  55                  60                  


Ile Ile Ser Asn Ala Thr Tyr Lys Glu Ile Gly Leu Leu Thr Cys Glu 
65                  70                  75                  80  


Ala Thr Val Asn Gly His Leu Tyr Lys Thr Asn Tyr Leu Thr His Arg 
                85                  90                  95      


Gln Thr Asn Thr Ile Ile Asp Val Val Leu Ser Pro Ser His Gly Ile 
            100                 105                 110         


Glu Leu Ser Val Gly Glu Lys Leu Val Leu Asn Cys Thr Ala Arg Thr 
        115                 120                 125             


Glu Leu Asn Val Gly Ile Asp Phe Asn Trp Glu Tyr Pro Ser Ser Lys 
    130                 135                 140                 


His Gln His Lys Lys Leu Val Asn Arg Asp Leu Lys Thr Gln Ser Gly 
145                 150                 155                 160 


Ser Glu Met Lys Lys Phe Leu Ser Thr Leu Thr Ile Asp Gly Val Thr 
                165                 170                 175     


Arg Ser Asp Gln Gly Leu Tyr Thr Cys Ala Ala Ser Ser Gly Leu Met 
            180                 185                 190         


Thr Lys Lys Asn Ser Thr Phe Val Arg Val His Glu Lys Asp Lys Thr 
        195                 200                 205             


His Thr Cys Pro Pro Cys Pro Ala Pro Glu Leu Leu Gly Gly Pro Ser 
    210                 215                 220                 


Val Phe Leu Phe Pro Pro Lys Pro Lys Asp Thr Leu Met Ile Ser Arg 
225                 230                 235                 240 


Thr Pro Glu Val Thr Cys Val Val Val Asp Val Ser His Glu Asp Pro 
                245                 250                 255     


Glu Val Lys Phe Asn Trp Tyr Val Asp Gly Val Glu Val His Asn Ala 
            260                 265                 270         


Lys Thr Lys Pro Arg Glu Glu Gln Tyr Asn Ser Thr Tyr Arg Val Val 
        275                 280                 285             


Ser Val Leu Thr Val Leu His Gln Asp Trp Leu Asn Gly Lys Glu Tyr 
    290                 295                 300                 


Lys Cys Lys Val Ser Asn Lys Ala Leu Pro Ala Pro Ile Glu Lys Thr 
305                 310                 315                 320 


Ile Ser Lys Ala Lys Gly Gln Pro Arg Glu Pro Gln Val Tyr Thr Leu 
                325                 330                 335     


Pro Pro Ser Arg Asp Glu Leu Thr Lys Asn Gln Val Ser Leu Thr Cys 
            340                 345                 350         


Leu Val Lys Gly Phe Tyr Pro Ser Asp Ile Ala Val Glu Trp Glu Ser 
        355                 360                 365             


Asn Gly Gln Pro Glu Asn Asn Tyr Lys Thr Thr Pro Pro Val Leu Asp 
    370                 375                 380                 


Ser Asp Gly Ser Phe Phe Leu Tyr Ser Lys Leu Thr Val Asp Lys Ser 
385                 390                 395                 400 


Arg Trp Gln Gln Gly Asn Val Phe Ser Cys Ser Val Met His Glu Ala 
                405                 410                 415     


Leu His Asn His Tyr Thr Gln Lys Ser Leu Ser Leu Ser Pro Gly Gly 
            420                 425                 430         


Gly Gly Gly Ser Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser Ile Ala 
        435                 440                 445             


Ala Lys Phe Asp Glu Ala Gln Ser Ala Ala Asp Ser Glu Ile Leu His 
    450                 455                 460                 


Leu Pro Asn Leu Thr Glu Gln Gln Arg His Tyr Phe Arg Arg Trp Leu 
465                 470                 475                 480 


Ser Asp Asp Pro Ser Val Ser Thr His Ile Leu Thr Gln Ala Gln His 
                485                 490                 495     


Leu Asn Asp Asp Gln Ala Pro Lys Ile Ala Ala Lys Phe Asp Glu Ala 
            500                 505                 510         


Gln Ser Ala Ala Asp Ser Glu Ile Leu His Leu Pro Asn Leu Thr Glu 
        515                 520                 525             


Gln Gln Arg His Tyr Phe Arg Arg Trp Leu Ser Asp Asp Pro Ser Val 
    530                 535                 540                 


Ser Thr His Ile Leu Thr Gln Ala Gln His Leu Asn Asp Asp Gln Ala 
545                 550                 555                 560 


Pro Lys Ile Ala Ala Lys Phe Asp Glu Ala Gln Ser Ala Ala Asp Ser 
                565                 570                 575     


Glu Ile Leu His Leu Pro Asn Leu Thr Glu Gln Gln Arg His Tyr Phe 
            580                 585                 590         


Arg Arg Trp Leu Ser Asp Asp Pro Ser Val Ser Thr His Ile Leu Thr 
        595                 600                 605             


Gln Ala Gln His Leu Asn Asp Asp Gln Ala Pro Lys Ile Ala Ala Lys 
    610                 615                 620                 


Phe Asp Glu Ala Gln Ser Ala Ala Asp Ser Glu Ile Leu His Leu Pro 
625                 630                 635                 640 


Asn Leu Thr Glu Gln Gln Arg His Tyr Phe Arg Arg Trp Leu Ser Asp 
                645                 650                 655     


Asp Pro Ser Val Ser Thr His Ile Leu Thr Gln Ala Gln His Leu Asn 
            660                 665                 670         


Asp Asp Gln Ala Pro Lys 
        675             


<210>  9
<211>  688
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  fusion protein 213185

<400>  9

Ser Asp Thr Gly Arg Pro Phe Val Glu Met Tyr Ser Glu Ile Pro Glu 
1               5                   10                  15      


Ile Ile His Met Thr Glu Gly Arg Glu Leu Val Ile Pro Cys Arg Val 
            20                  25                  30          


Thr Ser Pro Asn Ile Thr Val Thr Leu Lys Lys Phe Pro Leu Asp Thr 
        35                  40                  45              


Leu Ile Pro Asp Gly Lys Arg Ile Ile Trp Asp Ser Arg Lys Gly Phe 
    50                  55                  60                  


Ile Ile Ser Asn Ala Thr Tyr Lys Glu Ile Gly Leu Leu Thr Cys Glu 
65                  70                  75                  80  


Ala Thr Val Asn Gly His Leu Tyr Lys Thr Asn Tyr Leu Thr His Arg 
                85                  90                  95      


Gln Thr Asn Thr Ile Ile Asp Val Val Leu Ser Pro Ser His Gly Ile 
            100                 105                 110         


Glu Leu Ser Val Gly Glu Lys Leu Val Leu Asn Cys Thr Ala Arg Thr 
        115                 120                 125             


Glu Leu Asn Val Gly Ile Asp Phe Asn Trp Glu Tyr Pro Ser Ser Lys 
    130                 135                 140                 


His Gln His Lys Lys Leu Val Asn Arg Asp Leu Lys Thr Gln Ser Gly 
145                 150                 155                 160 


Ser Glu Met Lys Lys Phe Leu Ser Thr Leu Thr Ile Asp Gly Val Thr 
                165                 170                 175     


Arg Ser Asp Gln Gly Leu Tyr Thr Cys Ala Ala Ser Ser Gly Leu Met 
            180                 185                 190         


Thr Lys Lys Asn Ser Thr Phe Val Arg Val His Glu Lys Asp Lys Thr 
        195                 200                 205             


His Thr Cys Pro Pro Cys Pro Ala Pro Glu Leu Leu Gly Gly Pro Ser 
    210                 215                 220                 


Val Phe Leu Phe Pro Pro Lys Pro Lys Asp Thr Leu Met Ile Ser Arg 
225                 230                 235                 240 


Thr Pro Glu Val Thr Cys Val Val Val Asp Val Ser His Glu Asp Pro 
                245                 250                 255     


Glu Val Lys Phe Asn Trp Tyr Val Asp Gly Val Glu Val His Asn Ala 
            260                 265                 270         


Lys Thr Lys Pro Arg Glu Glu Gln Tyr Asn Ser Thr Tyr Arg Val Val 
        275                 280                 285             


Ser Val Leu Thr Val Leu His Gln Asp Trp Leu Asn Gly Lys Glu Tyr 
    290                 295                 300                 


Lys Cys Lys Val Ser Asn Lys Ala Leu Pro Ala Pro Ile Glu Lys Thr 
305                 310                 315                 320 


Ile Ser Lys Ala Lys Gly Gln Pro Arg Glu Pro Gln Val Tyr Thr Leu 
                325                 330                 335     


Pro Pro Ser Arg Asp Glu Leu Thr Lys Asn Gln Val Ser Leu Thr Cys 
            340                 345                 350         


Leu Val Lys Gly Phe Tyr Pro Ser Asp Ile Ala Val Glu Trp Glu Ser 
        355                 360                 365             


Asn Gly Gln Pro Glu Asn Asn Tyr Lys Thr Thr Pro Pro Val Leu Asp 
    370                 375                 380                 


Ser Asp Gly Ser Phe Phe Leu Tyr Ser Lys Leu Thr Val Asp Lys Ser 
385                 390                 395                 400 


Arg Trp Gln Gln Gly Asn Val Phe Ser Cys Ser Val Met His Glu Ala 
                405                 410                 415     


Leu His Asn His Tyr Thr Gln Lys Ser Leu Ser Leu Ser Pro Gly Gly 
            420                 425                 430         


Gly Gly Gly Ser Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser Ile Ala 
        435                 440                 445             


Ala Lys Phe Asp Glu Ala Gln Ser Ala Ala Asp Ser Glu Ile Leu His 
    450                 455                 460                 


Leu Pro Asn Leu Thr Glu Gln Gln Arg His Tyr Phe Arg Arg Trp Leu 
465                 470                 475                 480 


Ser Asp Asp Pro Ser Val Ser Thr His Ile Leu Thr Gln Ala Gln His 
                485                 490                 495     


Leu Asn Asp Asp Gln Ala Pro Lys Ile Ala Ala Lys Phe Asp Glu Ala 
            500                 505                 510         


Gln Ser Ala Ala Asp Ser Glu Ile Leu His Leu Pro Asn Leu Thr Glu 
        515                 520                 525             


Gln Gln Arg His Tyr Phe Arg Arg Trp Leu Ser Asp Asp Pro Ser Val 
    530                 535                 540                 


Ser Thr His Ile Leu Thr Gln Ala Gln His Leu Asn Asp Asp Gln Ala 
545                 550                 555                 560 


Pro Lys Ile Ala Ala Lys Phe Asp Glu Ala Gln Ser Ala Ala Asp Ser 
                565                 570                 575     


Glu Ile Leu His Leu Pro Asn Leu Thr Glu Gln Gln Arg His Tyr Phe 
            580                 585                 590         


Arg Arg Trp Leu Ser Asp Asp Pro Ser Val Ser Thr His Ile Leu Thr 
        595                 600                 605             


Gln Ala Gln His Leu Asn Asp Asp Gln Ala Pro Lys Ile Ala Ala Lys 
    610                 615                 620                 


Phe Asp Glu Ala Gln Ser Ala Ala Asp Ser Glu Ile Leu His Leu Pro 
625                 630                 635                 640 


Asn Leu Thr Glu Gln Gln Arg His Tyr Phe Arg Arg Trp Leu Ser Asp 
                645                 650                 655     


Asp Pro Ser Val Ser Thr His Ile Leu Thr Gln Ala Gln His Leu Asn 
            660                 665                 670         


Asp Asp Gln Ala Pro Lys Ser Ala Trp Ser His Pro Gln Phe Glu Lys 
        675                 680                 685             


<210>  10
<211>  562
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  fusion protein 212710

<400>  10

Ser Asp Thr Gly Arg Pro Phe Val Glu Met Tyr Ser Glu Ile Pro Glu 
1               5                   10                  15      


Ile Ile His Met Thr Glu Gly Arg Glu Leu Val Ile Pro Cys Arg Val 
            20                  25                  30          


Thr Ser Pro Asn Ile Thr Val Thr Leu Lys Lys Phe Pro Leu Asp Thr 
        35                  40                  45              


Leu Ile Pro Asp Gly Lys Arg Ile Ile Trp Asp Ser Arg Lys Gly Phe 
    50                  55                  60                  


Ile Ile Ser Asn Ala Thr Tyr Lys Glu Ile Gly Leu Leu Thr Cys Glu 
65                  70                  75                  80  


Ala Thr Val Asn Gly His Leu Tyr Lys Thr Asn Tyr Leu Thr His Arg 
                85                  90                  95      


Gln Thr Asn Thr Ile Ile Asp Val Val Leu Ser Pro Ser His Gly Ile 
            100                 105                 110         


Glu Leu Ser Val Gly Glu Lys Leu Val Leu Asn Cys Thr Ala Arg Thr 
        115                 120                 125             


Glu Leu Asn Val Gly Ile Asp Phe Asn Trp Glu Tyr Pro Ser Ser Lys 
    130                 135                 140                 


His Gln His Lys Lys Leu Val Asn Arg Asp Leu Lys Thr Gln Ser Gly 
145                 150                 155                 160 


Ser Glu Met Lys Lys Phe Leu Ser Thr Leu Thr Ile Asp Gly Val Thr 
                165                 170                 175     


Arg Ser Asp Gln Gly Leu Tyr Thr Cys Ala Ala Ser Ser Gly Leu Met 
            180                 185                 190         


Thr Lys Lys Asn Ser Thr Phe Val Arg Val His Glu Lys Asp Lys Thr 
        195                 200                 205             


His Thr Cys Pro Pro Cys Pro Ala Pro Glu Leu Leu Gly Gly Pro Ser 
    210                 215                 220                 


Val Phe Leu Phe Pro Pro Lys Pro Lys Asp Thr Leu Met Ile Ser Arg 
225                 230                 235                 240 


Thr Pro Glu Val Thr Cys Val Val Val Asp Val Ser His Glu Asp Pro 
                245                 250                 255     


Glu Val Lys Phe Asn Trp Tyr Val Asp Gly Val Glu Val His Asn Ala 
            260                 265                 270         


Lys Thr Lys Pro Arg Glu Glu Gln Tyr Asn Ser Thr Tyr Arg Val Val 
        275                 280                 285             


Ser Val Leu Thr Val Leu His Gln Asp Trp Leu Asn Gly Lys Glu Tyr 
    290                 295                 300                 


Lys Cys Lys Val Ser Asn Lys Ala Leu Pro Ala Pro Ile Glu Lys Thr 
305                 310                 315                 320 


Ile Ser Lys Ala Lys Gly Gln Pro Arg Glu Pro Gln Val Tyr Thr Leu 
                325                 330                 335     


Pro Pro Ser Arg Asp Glu Leu Thr Lys Asn Gln Val Ser Leu Thr Cys 
            340                 345                 350         


Leu Val Lys Gly Phe Tyr Pro Ser Asp Ile Ala Val Glu Trp Glu Ser 
        355                 360                 365             


Asn Gly Gln Pro Glu Asn Asn Tyr Lys Thr Thr Pro Pro Val Leu Asp 
    370                 375                 380                 


Ser Asp Gly Ser Phe Phe Leu Tyr Ser Lys Leu Thr Val Asp Lys Ser 
385                 390                 395                 400 


Arg Trp Gln Gln Gly Asn Val Phe Ser Cys Ser Val Met His Glu Ala 
                405                 410                 415     


Leu His Asn His Tyr Thr Gln Lys Ser Leu Ser Leu Ser Pro Gly Gly 
            420                 425                 430         


Gly Gly Gly Ser Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser Ile Ala 
        435                 440                 445             


Ala Lys Phe Asp Glu Ala Gln Gln Ala Ala Asp Lys Glu Ile Leu His 
    450                 455                 460                 


Leu Pro Asn Leu Thr Glu Gln Gln Arg Asn Tyr Phe Arg Gln Trp Leu 
465                 470                 475                 480 


Arg Asp Asp Pro Ser Val Ser Pro Thr Val Leu Gly Thr Ala Gln Gln 
                485                 490                 495     


Leu Asn Asp Ser Gln Ala Pro Lys Ile Ala Ala Lys Phe Asp Glu Ala 
            500                 505                 510         


Gln Gln Ala Ala Asp Lys Glu Ile Leu His Leu Pro Asn Leu Thr Glu 
        515                 520                 525             


Gln Gln Arg Asn Tyr Phe Arg Gln Trp Leu Arg Asp Asp Pro Ser Val 
    530                 535                 540                 


Ser Pro Thr Val Leu Gly Thr Ala Gln Gln Leu Asn Asp Ser Gln Ala 
545                 550                 555                 560 


Pro Lys 
        


<210>  11
<211>  572
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  fusion protein 212708

<400>  11

Ser Asp Thr Gly Arg Pro Phe Val Glu Met Tyr Ser Glu Ile Pro Glu 
1               5                   10                  15      


Ile Ile His Met Thr Glu Gly Arg Glu Leu Val Ile Pro Cys Arg Val 
            20                  25                  30          


Thr Ser Pro Asn Ile Thr Val Thr Leu Lys Lys Phe Pro Leu Asp Thr 
        35                  40                  45              


Leu Ile Pro Asp Gly Lys Arg Ile Ile Trp Asp Ser Arg Lys Gly Phe 
    50                  55                  60                  


Ile Ile Ser Asn Ala Thr Tyr Lys Glu Ile Gly Leu Leu Thr Cys Glu 
65                  70                  75                  80  


Ala Thr Val Asn Gly His Leu Tyr Lys Thr Asn Tyr Leu Thr His Arg 
                85                  90                  95      


Gln Thr Asn Thr Ile Ile Asp Val Val Leu Ser Pro Ser His Gly Ile 
            100                 105                 110         


Glu Leu Ser Val Gly Glu Lys Leu Val Leu Asn Cys Thr Ala Arg Thr 
        115                 120                 125             


Glu Leu Asn Val Gly Ile Asp Phe Asn Trp Glu Tyr Pro Ser Ser Lys 
    130                 135                 140                 


His Gln His Lys Lys Leu Val Asn Arg Asp Leu Lys Thr Gln Ser Gly 
145                 150                 155                 160 


Ser Glu Met Lys Lys Phe Leu Ser Thr Leu Thr Ile Asp Gly Val Thr 
                165                 170                 175     


Arg Ser Asp Gln Gly Leu Tyr Thr Cys Ala Ala Ser Ser Gly Leu Met 
            180                 185                 190         


Thr Lys Lys Asn Ser Thr Phe Val Arg Val His Glu Lys Asp Lys Thr 
        195                 200                 205             


His Thr Cys Pro Pro Cys Pro Ala Pro Glu Leu Leu Gly Gly Pro Ser 
    210                 215                 220                 


Val Phe Leu Phe Pro Pro Lys Pro Lys Asp Thr Leu Met Ile Ser Arg 
225                 230                 235                 240 


Thr Pro Glu Val Thr Cys Val Val Val Asp Val Ser His Glu Asp Pro 
                245                 250                 255     


Glu Val Lys Phe Asn Trp Tyr Val Asp Gly Val Glu Val His Asn Ala 
            260                 265                 270         


Lys Thr Lys Pro Arg Glu Glu Gln Tyr Asn Ser Thr Tyr Arg Val Val 
        275                 280                 285             


Ser Val Leu Thr Val Leu His Gln Asp Trp Leu Asn Gly Lys Glu Tyr 
    290                 295                 300                 


Lys Cys Lys Val Ser Asn Lys Ala Leu Pro Ala Pro Ile Glu Lys Thr 
305                 310                 315                 320 


Ile Ser Lys Ala Lys Gly Gln Pro Arg Glu Pro Gln Val Tyr Thr Leu 
                325                 330                 335     


Pro Pro Ser Arg Asp Glu Leu Thr Lys Asn Gln Val Ser Leu Thr Cys 
            340                 345                 350         


Leu Val Lys Gly Phe Tyr Pro Ser Asp Ile Ala Val Glu Trp Glu Ser 
        355                 360                 365             


Asn Gly Gln Pro Glu Asn Asn Tyr Lys Thr Thr Pro Pro Val Leu Asp 
    370                 375                 380                 


Ser Asp Gly Ser Phe Phe Leu Tyr Ser Lys Leu Thr Val Asp Lys Ser 
385                 390                 395                 400 


Arg Trp Gln Gln Gly Asn Val Phe Ser Cys Ser Val Met His Glu Ala 
                405                 410                 415     


Leu His Asn His Tyr Thr Gln Lys Ser Leu Ser Leu Ser Pro Gly Gly 
            420                 425                 430         


Gly Gly Gly Ser Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser Ile Ala 
        435                 440                 445             


Ala Lys Phe Asp Glu Ala Gln Gln Ala Ala Asp Lys Glu Ile Leu His 
    450                 455                 460                 


Leu Pro Asn Leu Thr Glu Gln Gln Arg Asn Tyr Phe Arg Gln Trp Leu 
465                 470                 475                 480 


Arg Asp Asp Pro Ser Val Ser Pro Thr Val Leu Gly Thr Ala Gln Gln 
                485                 490                 495     


Leu Asn Asp Ser Gln Ala Pro Lys Ile Ala Ala Lys Phe Asp Glu Ala 
            500                 505                 510         


Gln Gln Ala Ala Asp Lys Glu Ile Leu His Leu Pro Asn Leu Thr Glu 
        515                 520                 525             


Gln Gln Arg Asn Tyr Phe Arg Gln Trp Leu Arg Asp Asp Pro Ser Val 
    530                 535                 540                 


Ser Pro Thr Val Leu Gly Thr Ala Gln Gln Leu Asn Asp Ser Gln Ala 
545                 550                 555                 560 


Pro Lys Ser Ala Trp Ser His Pro Gln Phe Glu Lys 
                565                 570         


<210>  12
<211>  692
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  fusion protein 212709

<400>  12

Ser Asp Thr Gly Arg Pro Phe Val Glu Met Tyr Ser Glu Ile Pro Glu 
1               5                   10                  15      


Ile Ile His Met Thr Glu Gly Arg Glu Leu Val Ile Pro Cys Arg Val 
            20                  25                  30          


Thr Ser Pro Asn Ile Thr Val Thr Leu Lys Lys Phe Pro Leu Asp Thr 
        35                  40                  45              


Leu Ile Pro Asp Gly Lys Arg Ile Ile Trp Asp Ser Arg Lys Gly Phe 
    50                  55                  60                  


Ile Ile Ser Asn Ala Thr Tyr Lys Glu Ile Gly Leu Leu Thr Cys Glu 
65                  70                  75                  80  


Ala Thr Val Asn Gly His Leu Tyr Lys Thr Asn Tyr Leu Thr His Arg 
                85                  90                  95      


Gln Thr Asn Thr Ile Ile Asp Val Val Leu Ser Pro Ser His Gly Ile 
            100                 105                 110         


Glu Leu Ser Val Gly Glu Lys Leu Val Leu Asn Cys Thr Ala Arg Thr 
        115                 120                 125             


Glu Leu Asn Val Gly Ile Asp Phe Asn Trp Glu Tyr Pro Ser Ser Lys 
    130                 135                 140                 


His Gln His Lys Lys Leu Val Asn Arg Asp Leu Lys Thr Gln Ser Gly 
145                 150                 155                 160 


Ser Glu Met Lys Lys Phe Leu Ser Thr Leu Thr Ile Asp Gly Val Thr 
                165                 170                 175     


Arg Ser Asp Gln Gly Leu Tyr Thr Cys Ala Ala Ser Ser Gly Leu Met 
            180                 185                 190         


Thr Lys Lys Asn Ser Thr Phe Val Arg Val His Glu Lys Asp Lys Thr 
        195                 200                 205             


His Thr Cys Pro Pro Cys Pro Ala Pro Glu Leu Leu Gly Gly Pro Ser 
    210                 215                 220                 


Val Phe Leu Phe Pro Pro Lys Pro Lys Asp Thr Leu Met Ile Ser Arg 
225                 230                 235                 240 


Thr Pro Glu Val Thr Cys Val Val Val Asp Val Ser His Glu Asp Pro 
                245                 250                 255     


Glu Val Lys Phe Asn Trp Tyr Val Asp Gly Val Glu Val His Asn Ala 
            260                 265                 270         


Lys Thr Lys Pro Arg Glu Glu Gln Tyr Asn Ser Thr Tyr Arg Val Val 
        275                 280                 285             


Ser Val Leu Thr Val Leu His Gln Asp Trp Leu Asn Gly Lys Glu Tyr 
    290                 295                 300                 


Lys Cys Lys Val Ser Asn Lys Ala Leu Pro Ala Pro Ile Glu Lys Thr 
305                 310                 315                 320 


Ile Ser Lys Ala Lys Gly Gln Pro Arg Glu Pro Gln Val Tyr Thr Leu 
                325                 330                 335     


Pro Pro Ser Arg Asp Glu Leu Thr Lys Asn Gln Val Ser Leu Thr Cys 
            340                 345                 350         


Leu Val Lys Gly Phe Tyr Pro Ser Asp Ile Ala Val Glu Trp Glu Ser 
        355                 360                 365             


Asn Gly Gln Pro Glu Asn Asn Tyr Lys Thr Thr Pro Pro Val Leu Asp 
    370                 375                 380                 


Ser Asp Gly Ser Phe Phe Leu Tyr Ser Lys Leu Thr Val Asp Lys Ser 
385                 390                 395                 400 


Arg Trp Gln Gln Gly Asn Val Phe Ser Cys Ser Val Met His Glu Ala 
                405                 410                 415     


Leu His Asn His Tyr Thr Gln Lys Ser Leu Ser Leu Ser Pro Gly Gly 
            420                 425                 430         


Gly Gly Gly Ser Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser Ile Ala 
        435                 440                 445             


Ala Lys Phe Asp Glu Ala Gln Gln Ala Ala Asp Lys Glu Ile Leu His 
    450                 455                 460                 


Leu Pro Asn Leu Thr Glu Gln Gln Arg Asn Tyr Phe Arg Gln Trp Leu 
465                 470                 475                 480 


Arg Asp Asp Pro Ser Val Ser Pro Thr Val Leu Gly Thr Ala Gln Gln 
                485                 490                 495     


Leu Asn Asp Ser Gln Ala Pro Lys Ile Ala Ala Lys Phe Asp Glu Ala 
            500                 505                 510         


Gln Gln Ala Ala Asp Lys Glu Ile Leu His Leu Pro Asn Leu Thr Glu 
        515                 520                 525             


Gln Gln Arg Asn Tyr Phe Arg Gln Trp Leu Arg Asp Asp Pro Ser Val 
    530                 535                 540                 


Ser Pro Thr Val Leu Gly Thr Ala Gln Gln Leu Asn Asp Ser Gln Ala 
545                 550                 555                 560 


Pro Lys Gly Gly Gly Ser Ile Ala Ala Lys Phe Asp Glu Ala Gln Gln 
                565                 570                 575     


Ala Ala Asp Lys Glu Ile Leu His Leu Pro Asn Leu Thr Glu Gln Gln 
            580                 585                 590         


Arg Asn Tyr Phe Arg Gln Trp Leu Arg Asp Asp Pro Ser Val Ser Pro 
        595                 600                 605             


Thr Val Leu Gly Thr Ala Gln Gln Leu Asn Asp Ser Gln Ala Pro Lys 
    610                 615                 620                 


Ile Ala Ala Lys Phe Asp Glu Ala Gln Gln Ala Ala Asp Lys Glu Ile 
625                 630                 635                 640 


Leu His Leu Pro Asn Leu Thr Glu Gln Gln Arg Asn Tyr Phe Arg Gln 
                645                 650                 655     


Trp Leu Arg Asp Asp Pro Ser Val Ser Pro Thr Val Leu Gly Thr Ala 
            660                 665                 670         


Gln Gln Leu Asn Asp Ser Gln Ala Pro Lys Ser Ala Trp Ser His Pro 
        675                 680                 685             


Gln Phe Glu Lys 
    690         


<210>  13
<211>  562
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  control fusion protein with n-terminal Aflibercept and c-terminal
       a dimer of a non-Type-II-Collagen binding scaffold

<400>  13

Ser Asp Thr Gly Arg Pro Phe Val Glu Met Tyr Ser Glu Ile Pro Glu 
1               5                   10                  15      


Ile Ile His Met Thr Glu Gly Arg Glu Leu Val Ile Pro Cys Arg Val 
            20                  25                  30          


Thr Ser Pro Asn Ile Thr Val Thr Leu Lys Lys Phe Pro Leu Asp Thr 
        35                  40                  45              


Leu Ile Pro Asp Gly Lys Arg Ile Ile Trp Asp Ser Arg Lys Gly Phe 
    50                  55                  60                  


Ile Ile Ser Asn Ala Thr Tyr Lys Glu Ile Gly Leu Leu Thr Cys Glu 
65                  70                  75                  80  


Ala Thr Val Asn Gly His Leu Tyr Lys Thr Asn Tyr Leu Thr His Arg 
                85                  90                  95      


Gln Thr Asn Thr Ile Ile Asp Val Val Leu Ser Pro Ser His Gly Ile 
            100                 105                 110         


Glu Leu Ser Val Gly Glu Lys Leu Val Leu Asn Cys Thr Ala Arg Thr 
        115                 120                 125             


Glu Leu Asn Val Gly Ile Asp Phe Asn Trp Glu Tyr Pro Ser Ser Lys 
    130                 135                 140                 


His Gln His Lys Lys Leu Val Asn Arg Asp Leu Lys Thr Gln Ser Gly 
145                 150                 155                 160 


Ser Glu Met Lys Lys Phe Leu Ser Thr Leu Thr Ile Asp Gly Val Thr 
                165                 170                 175     


Arg Ser Asp Gln Gly Leu Tyr Thr Cys Ala Ala Ser Ser Gly Leu Met 
            180                 185                 190         


Thr Lys Lys Asn Ser Thr Phe Val Arg Val His Glu Lys Asp Lys Thr 
        195                 200                 205             


His Thr Cys Pro Pro Cys Pro Ala Pro Glu Leu Leu Gly Gly Pro Ser 
    210                 215                 220                 


Val Phe Leu Phe Pro Pro Lys Pro Lys Asp Thr Leu Met Ile Ser Arg 
225                 230                 235                 240 


Thr Pro Glu Val Thr Cys Val Val Val Asp Val Ser His Glu Asp Pro 
                245                 250                 255     


Glu Val Lys Phe Asn Trp Tyr Val Asp Gly Val Glu Val His Asn Ala 
            260                 265                 270         


Lys Thr Lys Pro Arg Glu Glu Gln Tyr Asn Ser Thr Tyr Arg Val Val 
        275                 280                 285             


Ser Val Leu Thr Val Leu His Gln Asp Trp Leu Asn Gly Lys Glu Tyr 
    290                 295                 300                 


Lys Cys Lys Val Ser Asn Lys Ala Leu Pro Ala Pro Ile Glu Lys Thr 
305                 310                 315                 320 


Ile Ser Lys Ala Lys Gly Gln Pro Arg Glu Pro Gln Val Tyr Thr Leu 
                325                 330                 335     


Pro Pro Ser Arg Asp Glu Leu Thr Lys Asn Gln Val Ser Leu Thr Cys 
            340                 345                 350         


Leu Val Lys Gly Phe Tyr Pro Ser Asp Ile Ala Val Glu Trp Glu Ser 
        355                 360                 365             


Asn Gly Gln Pro Glu Asn Asn Tyr Lys Thr Thr Pro Pro Val Leu Asp 
    370                 375                 380                 


Ser Asp Gly Ser Phe Phe Leu Tyr Ser Lys Leu Thr Val Asp Lys Ser 
385                 390                 395                 400 


Arg Trp Gln Gln Gly Asn Val Phe Ser Cys Ser Val Met His Glu Ala 
                405                 410                 415     


Leu His Asn His Tyr Thr Gln Lys Ser Leu Ser Leu Ser Pro Gly Gly 
            420                 425                 430         


Gly Gly Gly Ser Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser Ile Ala 
        435                 440                 445             


Ala Lys Phe Asp Glu Ala Gln Ser Ala Ala Asp Ser Glu Ile Leu His 
    450                 455                 460                 


Leu Pro Asn Leu Thr Glu Glu Gln Arg Asn Ala Phe Arg Gln Ser Leu 
465                 470                 475                 480 


Ser Asp Asp Pro Ser Val Ser Leu Glu Val Leu Gly Glu Ala Gln Lys 
                485                 490                 495     


Leu Asn Asp Ser Gln Ala Pro Lys Ile Ala Ala Lys Phe Asp Glu Ala 
            500                 505                 510         


Gln Ser Ala Ala Asp Ser Glu Ile Leu His Leu Pro Asn Leu Thr Glu 
        515                 520                 525             


Glu Gln Arg Asn Ala Phe Arg Gln Ser Leu Ser Asp Asp Pro Ser Val 
    530                 535                 540                 


Ser Leu Glu Val Leu Gly Glu Ala Gln Lys Leu Asn Asp Ser Gln Ala 
545                 550                 555                 560 


Pro Lys 
        


<210>  14
<211>  58
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  non Type II binding protein (PAdelFc)

<400>  14

Ile Ala Ala Lys Phe Asp Glu Ala Gln Ser Ala Ala Asp Ser Glu Ile 
1               5                   10                  15      


Leu His Leu Pro Asn Leu Thr Glu Glu Gln Arg Asn Ala Phe Arg Gln 
            20                  25                  30          


Ser Leu Ser Asp Asp Pro Ser Val Ser Leu Glu Val Leu Gly Glu Ala 
        35                  40                  45              


Gln Lys Leu Asn Asp Ser Gln Ala Pro Lys 
    50                  55              


<210>  15
<211>  430
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Aflibercept

<400>  15

Ser Asp Thr Gly Arg Pro Phe Val Glu Met Tyr Ser Glu Ile Pro Glu 
1               5                   10                  15      


Ile Ile His Met Thr Glu Gly Arg Glu Leu Val Ile Pro Cys Arg Val 
            20                  25                  30          


Thr Ser Pro Asn Ile Thr Val Thr Leu Lys Lys Phe Pro Leu Asp Thr 
        35                  40                  45              


Leu Ile Pro Asp Gly Lys Arg Ile Ile Trp Asp Ser Arg Lys Gly Phe 
    50                  55                  60                  


Ile Ile Ser Asn Ala Thr Tyr Lys Glu Ile Gly Leu Leu Thr Cys Glu 
65                  70                  75                  80  


Ala Thr Val Asn Gly His Leu Tyr Lys Thr Asn Tyr Leu Thr His Arg 
                85                  90                  95      


Gln Thr Asn Thr Ile Ile Asp Val Val Leu Ser Pro Ser His Gly Ile 
            100                 105                 110         


Glu Leu Ser Val Gly Glu Lys Leu Val Leu Asn Cys Thr Ala Arg Thr 
        115                 120                 125             


Glu Leu Asn Val Gly Ile Asp Phe Asn Trp Glu Tyr Pro Ser Ser Lys 
    130                 135                 140                 


His Gln His Lys Lys Leu Val Asn Arg Asp Leu Lys Thr Gln Ser Gly 
145                 150                 155                 160 


Ser Glu Met Lys Lys Phe Leu Ser Thr Leu Thr Ile Asp Gly Val Thr 
                165                 170                 175     


Arg Ser Asp Gln Gly Leu Tyr Thr Cys Ala Ala Ser Ser Gly Leu Met 
            180                 185                 190         


Thr Lys Lys Asn Ser Thr Phe Val Arg Val His Glu Lys Asp Lys Thr 
        195                 200                 205             


His Thr Cys Pro Pro Cys Pro Ala Pro Glu Leu Leu Gly Gly Pro Ser 
    210                 215                 220                 


Val Phe Leu Phe Pro Pro Lys Pro Lys Asp Thr Leu Met Ile Ser Arg 
225                 230                 235                 240 


Thr Pro Glu Val Thr Cys Val Val Val Asp Val Ser His Glu Asp Pro 
                245                 250                 255     


Glu Val Lys Phe Asn Trp Tyr Val Asp Gly Val Glu Val His Asn Ala 
            260                 265                 270         


Lys Thr Lys Pro Arg Glu Glu Gln Tyr Asn Ser Thr Tyr Arg Val Val 
        275                 280                 285             


Ser Val Leu Thr Val Leu His Gln Asp Trp Leu Asn Gly Lys Glu Tyr 
    290                 295                 300                 


Lys Cys Lys Val Ser Asn Lys Ala Leu Pro Ala Pro Ile Glu Lys Thr 
305                 310                 315                 320 


Ile Ser Lys Ala Lys Gly Gln Pro Arg Glu Pro Gln Val Tyr Thr Leu 
                325                 330                 335     


Pro Pro Ser Arg Asp Glu Leu Thr Lys Asn Gln Val Ser Leu Thr Cys 
            340                 345                 350         


Leu Val Lys Gly Phe Tyr Pro Ser Asp Ile Ala Val Glu Trp Glu Ser 
        355                 360                 365             


Asn Gly Gln Pro Glu Asn Asn Tyr Lys Thr Thr Pro Pro Val Leu Asp 
    370                 375                 380                 


Ser Asp Gly Ser Phe Phe Leu Tyr Ser Lys Leu Thr Val Asp Lys Ser 
385                 390                 395                 400 


Arg Trp Gln Gln Gly Asn Val Phe Ser Cys Ser Val Met His Glu Ala 
                405                 410                 415     


Leu His Asn His Tyr Thr Gln Lys Ser Leu Ser Leu Ser Pro 
            420                 425                 430 


<210>  16
<211>  1486
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  human Type II collagen

<400>  16

Met Ile Arg Leu Gly Ala Pro Gln Thr Leu Val Leu Leu Thr Leu Leu 
1               5                   10                  15      


Val Ala Ala Val Leu Arg Cys Gln Gly Gln Asp Val Gln Glu Ala Gly 
            20                  25                  30          


Ser Cys Val Gln Asp Gly Gln Arg Tyr Asn Asp Lys Asp Val Trp Lys 
        35                  40                  45              


Pro Glu Pro Cys Arg Ile Cys Val Cys Asp Thr Gly Thr Val Leu Cys 
    50                  55                  60                  


Asp Asp Ile Ile Cys Glu Asp Val Lys Asp Cys Leu Ser Pro Glu Ile 
65                  70                  75                  80  


Pro Phe Gly Glu Cys Cys Pro Ile Cys Pro Thr Asp Leu Ala Thr Ala 
                85                  90                  95      


Ser Gly Gln Pro Gly Pro Lys Gly Gln Lys Gly Glu Pro Gly Asp Ile 
            100                 105                 110         


Lys Asp Ile Val Gly Pro Lys Gly Pro Pro Gly Pro Gln Gly Pro Ala 
        115                 120                 125             


Gly Glu Gln Gly Pro Arg Gly Asp Arg Gly Asp Lys Gly Glu Lys Gly 
    130                 135                 140                 


Ala Pro Gly Pro Arg Gly Arg Asp Gly Glu Pro Gly Thr Pro Gly Asn 
145                 150                 155                 160 


Pro Gly Pro Pro Gly Pro Pro Gly Pro Pro Gly Pro Pro Gly Leu Gly 
                165                 170                 175     


Gly Asn Phe Ala Ala Gln Met Ala Gly Gly Phe Asp Glu Lys Ala Gly 
            180                 185                 190         


Gly Ala Gln Leu Gly Val Met Gln Gly Pro Met Gly Pro Met Gly Pro 
        195                 200                 205             


Arg Gly Pro Pro Gly Pro Ala Gly Ala Pro Gly Pro Gln Gly Phe Gln 
    210                 215                 220                 


Gly Asn Pro Gly Glu Pro Gly Glu Pro Gly Val Ser Gly Pro Met Gly 
225                 230                 235                 240 


Pro Arg Gly Pro Pro Gly Pro Pro Gly Lys Pro Gly Asp Asp Gly Glu 
                245                 250                 255     


Ala Gly Lys Pro Gly Lys Ala Gly Glu Arg Gly Pro Pro Gly Pro Gln 
            260                 265                 270         


Gly Ala Arg Gly Phe Pro Gly Thr Pro Gly Leu Pro Gly Val Lys Gly 
        275                 280                 285             


His Arg Gly Tyr Pro Gly Leu Asp Gly Ala Lys Gly Glu Ala Gly Ala 
    290                 295                 300                 


Pro Gly Val Lys Gly Glu Ser Gly Ser Pro Gly Glu Asn Gly Ser Pro 
305                 310                 315                 320 


Gly Pro Met Gly Pro Arg Gly Leu Pro Gly Glu Arg Gly Arg Thr Gly 
                325                 330                 335     


Pro Ala Gly Ala Ala Gly Ala Arg Gly Asn Asp Gly Gln Pro Gly Pro 
            340                 345                 350         


Ala Gly Pro Pro Gly Pro Val Gly Pro Ala Gly Gly Pro Gly Phe Pro 
        355                 360                 365             


Gly Ala Pro Gly Ala Lys Gly Glu Ala Gly Pro Thr Gly Ala Arg Gly 
    370                 375                 380                 


Pro Glu Gly Ala Gln Gly Pro Arg Gly Glu Pro Gly Thr Pro Gly Ser 
385                 390                 395                 400 


Pro Gly Pro Ala Gly Ala Ser Gly Asn Pro Gly Thr Asp Gly Ile Pro 
                405                 410                 415     


Gly Ala Lys Gly Ser Ala Gly Ala Pro Gly Ile Ala Gly Ala Pro Gly 
            420                 425                 430         


Phe Pro Gly Pro Arg Gly Pro Pro Gly Pro Gln Gly Ala Thr Gly Pro 
        435                 440                 445             


Leu Gly Pro Lys Gly Gln Thr Gly Glu Pro Gly Ile Ala Gly Phe Lys 
    450                 455                 460                 


Gly Glu Gln Gly Pro Lys Gly Glu Pro Gly Pro Ala Gly Pro Gln Gly 
465                 470                 475                 480 


Ala Pro Gly Pro Ala Gly Glu Glu Gly Lys Arg Gly Ala Arg Gly Glu 
                485                 490                 495     


Pro Gly Gly Val Gly Pro Ile Gly Pro Pro Gly Glu Arg Gly Ala Pro 
            500                 505                 510         


Gly Asn Arg Gly Phe Pro Gly Gln Asp Gly Leu Ala Gly Pro Lys Gly 
        515                 520                 525             


Ala Pro Gly Glu Arg Gly Pro Ser Gly Leu Ala Gly Pro Lys Gly Ala 
    530                 535                 540                 


Asn Gly Asp Pro Gly Arg Pro Gly Glu Pro Gly Leu Pro Gly Ala Arg 
545                 550                 555                 560 


Gly Leu Thr Gly Arg Pro Gly Asp Ala Gly Pro Gln Gly Lys Val Gly 
                565                 570                 575     


Pro Ser Gly Ala Pro Gly Glu Asp Gly Arg Pro Gly Pro Pro Gly Pro 
            580                 585                 590         


Gln Gly Ala Arg Gly Gln Pro Gly Val Met Gly Phe Pro Gly Pro Lys 
        595                 600                 605             


Gly Ala Asn Gly Glu Pro Gly Lys Ala Gly Glu Lys Gly Leu Pro Gly 
    610                 615                 620                 


Ala Pro Gly Leu Arg Gly Leu Pro Gly Lys Asp Gly Glu Thr Gly Ala 
625                 630                 635                 640 


Ala Gly Pro Pro Gly Pro Ala Gly Pro Ala Gly Glu Arg Gly Glu Gln 
                645                 650                 655     


Gly Ala Pro Gly Pro Ser Gly Phe Gln Gly Leu Pro Gly Pro Pro Gly 
            660                 665                 670         


Pro Pro Gly Glu Gly Gly Lys Pro Gly Asp Gln Gly Val Pro Gly Glu 
        675                 680                 685             


Ala Gly Ala Pro Gly Leu Val Gly Pro Arg Gly Glu Arg Gly Phe Pro 
    690                 695                 700                 


Gly Glu Arg Gly Ser Pro Gly Ala Gln Gly Leu Gln Gly Pro Arg Gly 
705                 710                 715                 720 


Leu Pro Gly Thr Pro Gly Thr Asp Gly Pro Lys Gly Ala Ser Gly Pro 
                725                 730                 735     


Ala Gly Pro Pro Gly Ala Gln Gly Pro Pro Gly Leu Gln Gly Met Pro 
            740                 745                 750         


Gly Glu Arg Gly Ala Ala Gly Ile Ala Gly Pro Lys Gly Asp Arg Gly 
        755                 760                 765             


Asp Val Gly Glu Lys Gly Pro Glu Gly Ala Pro Gly Lys Asp Gly Gly 
    770                 775                 780                 


Arg Gly Leu Thr Gly Pro Ile Gly Pro Pro Gly Pro Ala Gly Ala Asn 
785                 790                 795                 800 


Gly Glu Lys Gly Glu Val Gly Pro Pro Gly Pro Ala Gly Ser Ala Gly 
                805                 810                 815     


Ala Arg Gly Ala Pro Gly Glu Arg Gly Glu Thr Gly Pro Pro Gly Pro 
            820                 825                 830         


Ala Gly Phe Ala Gly Pro Pro Gly Ala Asp Gly Gln Pro Gly Ala Lys 
        835                 840                 845             


Gly Glu Gln Gly Glu Ala Gly Gln Lys Gly Asp Ala Gly Ala Pro Gly 
    850                 855                 860                 


Pro Gln Gly Pro Ser Gly Ala Pro Gly Pro Gln Gly Pro Thr Gly Val 
865                 870                 875                 880 


Thr Gly Pro Lys Gly Ala Arg Gly Ala Gln Gly Pro Pro Gly Ala Thr 
                885                 890                 895     


Gly Phe Pro Gly Ala Ala Gly Arg Val Gly Pro Pro Gly Ser Asn Gly 
            900                 905                 910         


Asn Pro Gly Pro Pro Gly Pro Pro Gly Pro Ser Gly Lys Asp Gly Pro 
        915                 920                 925             


Lys Gly Ala Arg Gly Asp Ser Gly Pro Pro Gly Arg Ala Gly Glu Pro 
    930                 935                 940                 


Gly Leu Gln Gly Pro Ala Gly Pro Pro Gly Glu Lys Gly Glu Pro Gly 
945                 950                 955                 960 


Asp Asp Gly Pro Ser Gly Ala Glu Gly Pro Pro Gly Pro Gln Gly Leu 
                965                 970                 975     


Ala Gly Gln Arg Gly Ile Val Gly Leu Pro Gly Gln Arg Gly Glu Arg 
            980                 985                 990         


Gly Phe Pro Gly Leu Pro Gly Pro  Ser Gly Glu Pro Gly  Lys Gln Gly 
        995                 1000                 1005             


Ala Pro  Gly Ala Ser Gly Asp  Arg Gly Pro Pro Pro  Val Gly Pro 
    1010                 1015                 1020             


Pro Gly  Leu Thr Gly Pro Ala  Gly Glu Pro Gly Arg  Glu Gly Ser 
    1025                 1030                 1035             


Pro Gly  Ala Asp Gly Pro Pro  Gly Arg Asp Gly Ala  Ala Gly Val 
    1040                 1045                 1050             


Lys Gly  Asp Arg Gly Glu Thr  Gly Ala Val Gly Ala  Pro Gly Ala 
    1055                 1060                 1065             


Pro Gly  Pro Pro Gly Ser Pro  Gly Pro Ala Gly Pro  Thr Gly Lys 
    1070                 1075                 1080             


Gln Gly  Asp Arg Gly Glu Ala  Gly Ala Gln Gly Pro  Met Gly Pro 
    1085                 1090                 1095             


Ser Gly  Pro Ala Gly Ala Arg  Gly Ile Gln Gly Pro  Gln Gly Pro 
    1100                 1105                 1110             


Arg Gly  Asp Lys Gly Glu Ala  Gly Glu Pro Gly Glu  Arg Gly Leu 
    1115                 1120                 1125             


Lys Gly  His Arg Gly Phe Thr  Gly Leu Gln Gly Leu  Pro Gly Pro 
    1130                 1135                 1140             


Pro Gly  Pro Ser Gly Asp Gln  Gly Ala Ser Gly Pro  Ala Gly Pro 
    1145                 1150                 1155             


Ser Gly  Pro Arg Gly Pro Pro  Gly Pro Val Gly Pro  Ser Gly Lys 
    1160                 1165                 1170             


Asp Gly  Ala Asn Gly Ile Pro  Gly Pro Ile Gly Pro  Pro Gly Pro 
    1175                 1180                 1185             


Arg Gly  Arg Ser Gly Glu Thr  Gly Pro Ala Gly Pro  Pro Gly Asn 
    1190                 1195                 1200             


Pro Gly  Pro Pro Gly Pro Pro  Gly Pro Pro Gly Pro  Gly Ile Asp 
    1205                 1210                 1215             


Met Ser  Ala Phe Ala Gly Leu  Gly Pro Arg Glu Lys  Gly Pro Asp 
    1220                 1225                 1230             


Pro Leu  Gln Tyr Met Arg Ala  Asp Gln Ala Ala Gly  Gly Leu Arg 
    1235                 1240                 1245             


Gln His  Asp Ala Glu Val Asp  Ala Thr Leu Lys Ser  Leu Asn Asn 
    1250                 1255                 1260             


Gln Ile  Glu Ser Ile Arg Ser  Pro Glu Gly Ser Arg  Lys Asn Pro 
    1265                 1270                 1275             


Ala Arg  Thr Cys Arg Asp Leu  Lys Leu Cys His Pro  Glu Trp Lys 
    1280                 1285                 1290             


Ser Gly  Asp Tyr Trp Ile Asp  Pro Asn Gln Gly Cys  Thr Leu Asp 
    1295                 1300                 1305             


Ala Met  Lys Val Phe Cys Asn  Met Glu Thr Gly Glu  Thr Cys Val 
    1310                 1315                 1320             


Tyr Pro  Asn Pro Ala Asn Val  Pro Lys Lys Asn Trp  Trp Ser Ser 
    1325                 1330                 1335             


Lys Ser  Lys Glu Lys Lys His  Ile Trp Phe Gly Glu  Thr Ile Asn 
    1340                 1345                 1350             


Gly Gly  Phe His Phe Ser Tyr  Gly Asp Asp Asn Leu  Ala Pro Asn 
    1355                 1360                 1365             


Thr Ala  Asn Val Gln Met Thr  Phe Leu Arg Leu Leu  Ser Thr Glu 
    1370                 1375                 1380             


Gly Ser  Gln Asn Ile Thr Tyr  His Cys Lys Asn Ser  Ile Ala Tyr 
    1385                 1390                 1395             


Leu Asp  Glu Ala Ala Gly Asn  Leu Lys Lys Ala Leu  Leu Ile Gln 
    1400                 1405                 1410             


Gly Ser  Asn Asp Val Glu Ile  Arg Ala Glu Gly Asn  Ser Arg Phe 
    1415                 1420                 1425             


Thr Tyr  Thr Ala Leu Lys Asp  Gly Cys Thr Lys His  Thr Gly Lys 
    1430                 1435                 1440             


Trp Gly  Lys Thr Val Ile Glu  Tyr Arg Ser Gln Lys  Thr Ser Arg 
    1445                 1450                 1455             


Leu Pro  Ile Ile Asp Ile Ala  Pro Met Asp Ile Gly  Gly Pro Glu 
    1460                 1465                 1470             


Gln Glu  Phe Gly Val Asp Ile  Gly Pro Val Cys Phe  Leu 
    1475                 1480                 1485     


<210>  17
<211>  4
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  linker

<400>  17

Gly Gly Gly Ser 
1               


<210>  18
<211>  5
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  linker

<400>  18

Gly Gly Gly Gly Ser 
1               5   


<210>  19
<211>  16
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  linker

<400>  19

Gly Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser 
1               5                   10                  15      


<210>  20
<211>  20
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  linker

<400>  20

Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser Gly 
1               5                   10                  15      


Gly Gly Gly Ser 
            20  


<210>  21
<211>  562
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  fusion protein 217793

<400>  21

Ile Ala Ala Lys Phe Asp Glu Ala Gln Ser Ala Ala Asp Ser Glu Ile 
1               5                   10                  15      


Leu His Leu Pro Asn Leu Thr Glu Gln Gln Arg His Tyr Phe Arg Arg 
            20                  25                  30          


Trp Leu Ser Asp Asp Pro Ser Val Ser Thr His Ile Leu Thr Gln Ala 
        35                  40                  45              


Gln His Leu Asn Asp Asp Gln Ala Pro Lys Ile Ala Ala Lys Phe Asp 
    50                  55                  60                  


Glu Ala Gln Ser Ala Ala Asp Ser Glu Ile Leu His Leu Pro Asn Leu 
65                  70                  75                  80  


Thr Glu Gln Gln Arg His Tyr Phe Arg Arg Trp Leu Ser Asp Asp Pro 
                85                  90                  95      


Ser Val Ser Thr His Ile Leu Thr Gln Ala Gln His Leu Asn Asp Asp 
            100                 105                 110         


Gln Ala Pro Lys Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser Gly Gly 
        115                 120                 125             


Gly Gly Ser Ser Asp Thr Gly Arg Pro Phe Val Glu Met Tyr Ser Glu 
    130                 135                 140                 


Ile Pro Glu Ile Ile His Met Thr Glu Gly Arg Glu Leu Val Ile Pro 
145                 150                 155                 160 


Cys Arg Val Thr Ser Pro Asn Ile Thr Val Thr Leu Lys Lys Phe Pro 
                165                 170                 175     


Leu Asp Thr Leu Ile Pro Asp Gly Lys Arg Ile Ile Trp Asp Ser Arg 
            180                 185                 190         


Lys Gly Phe Ile Ile Ser Asn Ala Thr Tyr Lys Glu Ile Gly Leu Leu 
        195                 200                 205             


Thr Cys Glu Ala Thr Val Asn Gly His Leu Tyr Lys Thr Asn Tyr Leu 
    210                 215                 220                 


Thr His Arg Gln Thr Asn Thr Ile Ile Asp Val Val Leu Ser Pro Ser 
225                 230                 235                 240 


His Gly Ile Glu Leu Ser Val Gly Glu Lys Leu Val Leu Asn Cys Thr 
                245                 250                 255     


Ala Arg Thr Glu Leu Asn Val Gly Ile Asp Phe Asn Trp Glu Tyr Pro 
            260                 265                 270         


Ser Ser Lys His Gln His Lys Lys Leu Val Asn Arg Asp Leu Lys Thr 
        275                 280                 285             


Gln Ser Gly Ser Glu Met Lys Lys Phe Leu Ser Thr Leu Thr Ile Asp 
    290                 295                 300                 


Gly Val Thr Arg Ser Asp Gln Gly Leu Tyr Thr Cys Ala Ala Ser Ser 
305                 310                 315                 320 


Gly Leu Met Thr Lys Lys Asn Ser Thr Phe Val Arg Val His Glu Lys 
                325                 330                 335     


Asp Lys Thr His Thr Cys Pro Pro Cys Pro Ala Pro Glu Leu Leu Gly 
            340                 345                 350         


Gly Pro Ser Val Phe Leu Phe Pro Pro Lys Pro Lys Asp Thr Leu Met 
        355                 360                 365             


Ile Ser Arg Thr Pro Glu Val Thr Cys Val Val Val Asp Val Ser His 
    370                 375                 380                 


Glu Asp Pro Glu Val Lys Phe Asn Trp Tyr Val Asp Gly Val Glu Val 
385                 390                 395                 400 


His Asn Ala Lys Thr Lys Pro Arg Glu Glu Gln Tyr Asn Ser Thr Tyr 
                405                 410                 415     


Arg Val Val Ser Val Leu Thr Val Leu His Gln Asp Trp Leu Asn Gly 
            420                 425                 430         


Lys Glu Tyr Lys Cys Lys Val Ser Asn Lys Ala Leu Pro Ala Pro Ile 
        435                 440                 445             


Glu Lys Thr Ile Ser Lys Ala Lys Gly Gln Pro Arg Glu Pro Gln Val 
    450                 455                 460                 


Tyr Thr Leu Pro Pro Ser Arg Asp Glu Leu Thr Lys Asn Gln Val Ser 
465                 470                 475                 480 


Leu Thr Cys Leu Val Lys Gly Phe Tyr Pro Ser Asp Ile Ala Val Glu 
                485                 490                 495     


Trp Glu Ser Asn Gly Gln Pro Glu Asn Asn Tyr Lys Thr Thr Pro Pro 
            500                 505                 510         


Val Leu Asp Ser Asp Gly Ser Phe Phe Leu Tyr Ser Lys Leu Thr Val 
        515                 520                 525             


Asp Lys Ser Arg Trp Gln Gln Gly Asn Val Phe Ser Cys Ser Val Met 
    530                 535                 540                 


His Glu Ala Leu His Asn His Tyr Thr Gln Lys Ser Leu Ser Leu Ser 
545                 550                 555                 560 


Pro Gly 
        


<210>  22
<211>  703
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  fusion protein 218480

<400>  22

Ile Ala Ala Lys Phe Asp Glu Ala Gln Ser Ala Ala Asp Ser Glu Ile 
1               5                   10                  15      


Leu His Leu Pro Asn Leu Thr Glu Gln Gln Arg His Tyr Phe Arg Arg 
            20                  25                  30          


Trp Leu Ser Asp Asp Pro Ser Val Ser Thr His Ile Leu Thr Gln Ala 
        35                  40                  45              


Gln His Leu Asn Asp Asp Gln Ala Pro Lys Ile Ala Ala Lys Phe Asp 
    50                  55                  60                  


Glu Ala Gln Ser Ala Ala Asp Ser Glu Ile Leu His Leu Pro Asn Leu 
65                  70                  75                  80  


Thr Glu Gln Gln Arg His Tyr Phe Arg Arg Trp Leu Ser Asp Asp Pro 
                85                  90                  95      


Ser Val Ser Thr His Ile Leu Thr Gln Ala Gln His Leu Asn Asp Asp 
            100                 105                 110         


Gln Ala Pro Lys Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser Gly Gly 
        115                 120                 125             


Gly Gly Ser Ser Asp Thr Gly Arg Pro Phe Val Glu Met Tyr Ser Glu 
    130                 135                 140                 


Ile Pro Glu Ile Ile His Met Thr Glu Gly Arg Glu Leu Val Ile Pro 
145                 150                 155                 160 


Cys Arg Val Thr Ser Pro Asn Ile Thr Val Thr Leu Lys Lys Phe Pro 
                165                 170                 175     


Leu Asp Thr Leu Ile Pro Asp Gly Lys Arg Ile Ile Trp Asp Ser Arg 
            180                 185                 190         


Lys Gly Phe Ile Ile Ser Asn Ala Thr Tyr Lys Glu Ile Gly Leu Leu 
        195                 200                 205             


Thr Cys Glu Ala Thr Val Asn Gly His Leu Tyr Lys Thr Asn Tyr Leu 
    210                 215                 220                 


Thr His Arg Gln Thr Asn Thr Ile Ile Asp Val Val Leu Ser Pro Ser 
225                 230                 235                 240 


His Gly Ile Glu Leu Ser Val Gly Glu Lys Leu Val Leu Asn Cys Thr 
                245                 250                 255     


Ala Arg Thr Glu Leu Asn Val Gly Ile Asp Phe Asn Trp Glu Tyr Pro 
            260                 265                 270         


Ser Ser Lys His Gln His Lys Lys Leu Val Asn Arg Asp Leu Lys Thr 
        275                 280                 285             


Gln Ser Gly Ser Glu Met Lys Lys Phe Leu Ser Thr Leu Thr Ile Asp 
    290                 295                 300                 


Gly Val Thr Arg Ser Asp Gln Gly Leu Tyr Thr Cys Ala Ala Ser Ser 
305                 310                 315                 320 


Gly Leu Met Thr Lys Lys Asn Ser Thr Phe Val Arg Val His Glu Lys 
                325                 330                 335     


Asp Lys Thr His Thr Cys Pro Pro Cys Pro Ala Pro Glu Leu Leu Gly 
            340                 345                 350         


Gly Pro Ser Val Phe Leu Phe Pro Pro Lys Pro Lys Asp Thr Leu Met 
        355                 360                 365             


Ile Ser Arg Thr Pro Glu Val Thr Cys Val Val Val Asp Val Ser His 
    370                 375                 380                 


Glu Asp Pro Glu Val Lys Phe Asn Trp Tyr Val Asp Gly Val Glu Val 
385                 390                 395                 400 


His Asn Ala Lys Thr Lys Pro Arg Glu Glu Gln Tyr Asn Ser Thr Tyr 
                405                 410                 415     


Arg Val Val Ser Val Leu Thr Val Leu His Gln Asp Trp Leu Asn Gly 
            420                 425                 430         


Lys Glu Tyr Lys Cys Lys Val Ser Asn Lys Ala Leu Pro Ala Pro Ile 
        435                 440                 445             


Glu Lys Thr Ile Ser Lys Ala Lys Gly Gln Pro Arg Glu Pro Gln Val 
    450                 455                 460                 


Tyr Thr Leu Pro Pro Ser Arg Asp Glu Leu Thr Lys Asn Gln Val Ser 
465                 470                 475                 480 


Leu Thr Cys Leu Val Lys Gly Phe Tyr Pro Ser Asp Ile Ala Val Glu 
                485                 490                 495     


Trp Glu Ser Asn Gly Gln Pro Glu Asn Asn Tyr Lys Thr Thr Pro Pro 
            500                 505                 510         


Val Leu Asp Ser Asp Gly Ser Phe Phe Leu Tyr Ser Lys Leu Thr Val 
        515                 520                 525             


Asp Lys Ser Arg Trp Gln Gln Gly Asn Val Phe Ser Cys Ser Val Met 
    530                 535                 540                 


His Glu Ala Leu His Asn His Tyr Thr Gln Lys Ser Leu Ser Leu Ser 
545                 550                 555                 560 


Pro Gly Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser Gly Gly Gly Gly 
                565                 570                 575     


Ser Ile Ala Ala Lys Phe Asp Glu Ala Gln Gln Ala Ala Asp Lys Glu 
            580                 585                 590         


Ile Leu His Leu Pro Asn Leu Thr Glu Gln Gln Arg Asn Tyr Phe Arg 
        595                 600                 605             


Gln Trp Leu Arg Asp Asp Pro Ser Val Ser Pro Thr Val Leu Gly Thr 
    610                 615                 620                 


Ala Gln Gln Leu Asn Asp Ser Gln Ala Pro Lys Ile Ala Ala Lys Phe 
625                 630                 635                 640 


Asp Glu Ala Gln Gln Ala Ala Asp Lys Glu Ile Leu His Leu Pro Asn 
                645                 650                 655     


Leu Thr Glu Gln Gln Arg Asn Tyr Phe Arg Gln Trp Leu Arg Asp Asp 
            660                 665                 670         


Pro Ser Val Ser Pro Thr Val Leu Gly Thr Ala Gln Gln Leu Asn Asp 
        675                 680                 685             


Ser Gln Ala Pro Lys Ser Ala Trp Ser His Pro Gln Phe Glu Lys 
    690                 695                 700             


