﻿                         序列表

<110>  南京北恒生物科技有限公司

<120>  工程化免疫细胞及其用途

<130>  BHCN38V1

<160>  62

<170>  SIPOSequenceListing 1.0

<210>  1
<211>  726
<212>  DNA
<213>  Artificial Sequence(Artificial Sequence)

<220>
<223>  CD19 scFv


<400>  1
gacatccaga tgacacagac tacatcctcc ctgtctgcct ctctgggaga cagagtcacc        60
atcagttgca gggcaagtca ggacattagt aaatatttaa attggtatca gcagaaacca       120
gatggaactg ttaaactcct gatctaccat acatcaagat tacactcagg agtcccatca       180
aggttcagtg gcagtgggtc tggaacagat tattctctca ccattagcaa cctggagcaa       240
gaagatattg ccacttactt ttgccaacag ggtaatacgc ttccgtacac gttcggaggg       300
gggaccaagc tggagatcac aggtggcggt ggctcgggcg gtggtgggtc gggtggcggc       360
ggatctgagg tgaaactgca ggagtcagga cctggcctgg tggcgccctc acagagcctg       420
tccgtcacat gcactgtctc aggggtctca ttacccgact atggtgtaag ctggattcgc       480
cagcctccac gaaagggtct ggagtggctg ggagtaatat ggggtagtga aaccacatac       540
tataattcag ctctcaaatc cagactgacc atcatcaagg acaactccaa gagccaagtt       600
ttcttaaaaa tgaacagtct gcaaactgat gacacagcca tttactactg tgccaaacat       660
tattactacg gtggtagcta tgctatggac tactggggcc aaggaacctc agtcaccgtc       720
tcctca                                                                  726

<210>  2
<211>  242
<212>  PRT
<213>  Artificial Sequence(Artificial Sequence)

<220>
<223>  CD19 scFv


<400>  2
Asp Ile Gln Met Thr Gln Thr Thr Ser Ser Leu Ser Ala Ser Leu Gly 
1               5                   10                  15      
Asp Arg Val Thr Ile Ser Cys Arg Ala Ser Gln Asp Ile Ser Lys Tyr 
            20                  25                  30          
Leu Asn Trp Tyr Gln Gln Lys Pro Asp Gly Thr Val Lys Leu Leu Ile 
        35                  40                  45              
Tyr His Thr Ser Arg Leu His Ser Gly Val Pro Ser Arg Phe Ser Gly 
    50                  55                  60                  
Ser Gly Ser Gly Thr Asp Tyr Ser Leu Thr Ile Ser Asn Leu Glu Gln 
65                  70                  75                  80  
Glu Asp Ile Ala Thr Tyr Phe Cys Gln Gln Gly Asn Thr Leu Pro Tyr 
                85                  90                  95      
Thr Phe Gly Gly Gly Thr Lys Leu Glu Ile Thr Gly Gly Gly Gly Ser 
            100                 105                 110         
Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser Glu Val Lys Leu Gln Glu 
        115                 120                 125             
Ser Gly Pro Gly Leu Val Ala Pro Ser Gln Ser Leu Ser Val Thr Cys 
    130                 135                 140                 
Thr Val Ser Gly Val Ser Leu Pro Asp Tyr Gly Val Ser Trp Ile Arg 
145                 150                 155                 160 
Gln Pro Pro Arg Lys Gly Leu Glu Trp Leu Gly Val Ile Trp Gly Ser 
                165                 170                 175     
Glu Thr Thr Tyr Tyr Asn Ser Ala Leu Lys Ser Arg Leu Thr Ile Ile 
            180                 185                 190         
Lys Asp Asn Ser Lys Ser Gln Val Phe Leu Lys Met Asn Ser Leu Gln 
        195                 200                 205             
Thr Asp Asp Thr Ala Ile Tyr Tyr Cys Ala Lys His Tyr Tyr Tyr Gly 
    210                 215                 220                 
Gly Ser Tyr Ala Met Asp Tyr Trp Gly Gln Gly Thr Ser Val Thr Val 
225                 230                 235                 240 
Ser Ser 
        

<210>  3
<211>  75
<212>  DNA
<213>  Artificial Sequence(Artificial Sequence)

<220>
<223>  CD8α跨膜结构域


<400>  3
atctacatct gggcgccctt ggccgggact tgtggggtcc ttctcctgtc actggttatc        60
accctttact gcaaa                                                         75

<210>  4
<211>  25
<212>  PRT
<213>  Artificial Sequence(Artificial Sequence)

<220>
<223>  CD8α跨膜结构域


<400>  4
Ile Tyr Ile Trp Ala Pro Leu Ala Gly Thr Cys Gly Val Leu Leu Leu 
1               5                   10                  15      
Ser Leu Val Ile Thr Leu Tyr Cys Lys 
            20                  25  

<210>  5
<211>  120
<212>  DNA
<213>  Artificial Sequence(Artificial Sequence)

<220>
<223>  4-1BB共刺激结构域


<400>  5
cggggcagaa agaaactcct gtatatattc aaacaaccat ttatgagacc agtacaaact        60
actcaagagg aagatggctg tagctgccga tttccagaag aagaagaagg aggatgtgaa       120

<210>  6
<211>  40
<212>  PRT
<213>  Artificial Sequence(Artificial Sequence)

<220>
<223>  4-1BB共刺激结构域


<400>  6
Arg Gly Arg Lys Lys Leu Leu Tyr Ile Phe Lys Gln Pro Phe Met Arg 
1               5                   10                  15      
Pro Val Gln Thr Thr Gln Glu Glu Asp Gly Cys Ser Cys Arg Phe Pro 
            20                  25                  30          
Glu Glu Glu Glu Gly Gly Cys Glu 
        35                  40  

<210>  7
<211>  339
<212>  DNA
<213>  Artificial Sequence(Artificial Sequence)

<220>
<223>  CD3ζ信号传导结构域


<400>  7
ctgagagtga agttcagcag gagcgcagac gcccccgcgt accagcaggg ccagaaccag        60
ctctataacg agctcaatct aggacgaaga gaggagtacg atgttttgga caagagacgt       120
ggccgggacc ctgagatggg gggaaagccg agaaggaaga accctcagga aggcctgtac       180
aatgaactgc agaaagataa gatggcggag gcctacagtg agattgggat gaaaggcgag       240
cgccggaggg gcaaggggca cgatggcctt taccagggtc tcagtacagc caccaaggac       300
acctacgacg cccttcacat gcaggccctg ccccctcgc                              339

<210>  8
<211>  113
<212>  PRT
<213>  Artificial Sequence(Artificial Sequence)

<220>
<223>  CD3ζ信号传导结构域


<400>  8
Leu Arg Val Lys Phe Ser Arg Ser Ala Asp Ala Pro Ala Tyr Gln Gln 
1               5                   10                  15      
Gly Gln Asn Gln Leu Tyr Asn Glu Leu Asn Leu Gly Arg Arg Glu Glu 
            20                  25                  30          
Tyr Asp Val Leu Asp Lys Arg Arg Gly Arg Asp Pro Glu Met Gly Gly 
        35                  40                  45              
Lys Pro Arg Arg Lys Asn Pro Gln Glu Gly Leu Tyr Asn Glu Leu Gln 
    50                  55                  60                  
Lys Asp Lys Met Ala Glu Ala Tyr Ser Glu Ile Gly Met Lys Gly Glu 
65                  70                  75                  80  
Arg Arg Arg Gly Lys Gly His Asp Gly Leu Tyr Gln Gly Leu Ser Thr 
                85                  90                  95      
Ala Thr Lys Asp Thr Tyr Asp Ala Leu His Met Gln Ala Leu Pro Pro 
            100                 105                 110         
Arg 
    

<210>  9
<211>  63
<212>  DNA
<213>  Artificial Sequence(Artificial Sequence)

<220>
<223>  CD8α信号肽


<400>  9
atggccttac cagtgaccgc cttgctcctg ccgctggcct tgctgctcca cgccgccagg        60
ccg                                                                      63

<210>  10
<211>  21
<212>  PRT
<213>  Artificial Sequence(Artificial Sequence)

<220>
<223>  CD8α信号肽


<400>  10
Met Ala Leu Pro Val Thr Ala Leu Leu Leu Pro Leu Ala Leu Leu Leu 
1               5                   10                  15      
His Ala Ala Arg Pro 
            20      

<210>  11
<211>  135
<212>  DNA
<213>  Artificial Sequence(Artificial Sequence)

<220>
<223>  CD8α铰链区


<400>  11
accacgacgc cagcgccgcg accaccaaca ccggcgccca ccatcgcgtc gcagcccctg        60
tccctgcgcc cagaggcgtg ccggccagcg gcggggggcg cagtgcacac gagggggctg       120
gacttcgcct gtgat                                                        135

<210>  12
<211>  45
<212>  PRT
<213>  Artificial Sequence(Artificial Sequence)

<220>
<223>  CD8α铰链区


<400>  12
Thr Thr Thr Pro Ala Pro Arg Pro Pro Thr Pro Ala Pro Thr Ile Ala 
1               5                   10                  15      
Ser Gln Pro Leu Ser Leu Arg Pro Glu Ala Cys Arg Pro Ala Ala Gly 
            20                  25                  30          
Gly Ala Val His Thr Arg Gly Leu Asp Phe Ala Cys Asp 
        35                  40                  45  

<210>  13
<211>  714
<212>  DNA
<213>  Artificial Sequence(Artificial Sequence)

<220>
<223>  mCD19 scFv


<400>  13
gacatccaga tgacccagag ccctgccagc ctgtctacca gcctgggcga gacagtgacc        60
atccagtgtc aggccagcga ggacatctac tctggcctgg cttggtatca gcagaagccc       120
ggcaagagcc ctcagctgct gatctacggc gccagcgacc tgcaggacgg cgtgcctagc       180
agattcagcg gcagcggctc cggaacccag tacagcctga agatcaccag catgcagacc       240
gaggacgagg gcgtgtactt ctgccagcaa ggcctgacct accctagaac cttcggagga       300
ggcaccaagc tggaactgaa gggcggaggc ggaagtggag gcggaggatc tggcggcgga       360
ggctctgaag tgcagctgca gcagtctggc gctgaactgg tccggcctgg cactagcgtg       420
aagctgtcct gcaaggtgtc cggcgacacc atcaccttct actacatgca cttcgtgaag       480
cagaggccag gacagggcct ggaatggatc ggcagaatcg accctgagga cgagagcacc       540
aagtacagcg agaagttcaa gaacaaggcc accctgaccg ccgacaccag cagcaacacc       600
gcctacctga agctgtctag cctgacctcc gaggacaccg ccacctactt ttgcatctac       660
ggcggctact acttcgacta ctggggccag ggcgtgatgg tcaccgtgtc cagc             714

<210>  14
<211>  238
<212>  PRT
<213>  Artificial Sequence(Artificial Sequence)

<220>
<223>  mCD19 scFv


<400>  14
Asp Ile Gln Met Thr Gln Ser Pro Ala Ser Leu Ser Thr Ser Leu Gly 
1               5                   10                  15      
Glu Thr Val Thr Ile Gln Cys Gln Ala Ser Glu Asp Ile Tyr Ser Gly 
            20                  25                  30          
Leu Ala Trp Tyr Gln Gln Lys Pro Gly Lys Ser Pro Gln Leu Leu Ile 
        35                  40                  45              
Tyr Gly Ala Ser Asp Leu Gln Asp Gly Val Pro Ser Arg Phe Ser Gly 
    50                  55                  60                  
Ser Gly Ser Gly Thr Gln Tyr Ser Leu Lys Ile Thr Ser Met Gln Thr 
65                  70                  75                  80  
Glu Asp Glu Gly Val Tyr Phe Cys Gln Gln Gly Leu Thr Tyr Pro Arg 
                85                  90                  95      
Thr Phe Gly Gly Gly Thr Lys Leu Glu Leu Lys Gly Gly Gly Gly Ser 
            100                 105                 110         
Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser Glu Val Gln Leu Gln Gln 
        115                 120                 125             
Ser Gly Ala Glu Leu Val Arg Pro Gly Thr Ser Val Lys Leu Ser Cys 
    130                 135                 140                 
Lys Val Ser Gly Asp Thr Ile Thr Phe Tyr Tyr Met His Phe Val Lys 
145                 150                 155                 160 
Gln Arg Pro Gly Gln Gly Leu Glu Trp Ile Gly Arg Ile Asp Pro Glu 
                165                 170                 175     
Asp Glu Ser Thr Lys Tyr Ser Glu Lys Phe Lys Asn Lys Ala Thr Leu 
            180                 185                 190         
Thr Ala Asp Thr Ser Ser Asn Thr Ala Tyr Leu Lys Leu Ser Ser Leu 
        195                 200                 205             
Thr Ser Glu Asp Thr Ala Thr Tyr Phe Cys Ile Tyr Gly Gly Tyr Tyr 
    210                 215                 220                 
Phe Asp Tyr Trp Gly Gln Gly Val Met Val Thr Val Ser Ser 
225                 230                 235             

<210>  15
<211>  63
<212>  DNA
<213>  Artificial Sequence(Artificial Sequence)

<220>
<223>  mCD8α跨膜结构域


<400>  15
atctgggcac ccttggccgg aatctgcgtg gcccttctgc tgtccttgat catcactctc        60
atc                                                                      63

<210>  16
<211>  21
<212>  PRT
<213>  Artificial Sequence(Artificial Sequence)

<220>
<223>  mCD8α跨膜结构域


<400>  16
Ile Trp Ala Pro Leu Ala Gly Ile Cys Val Ala Leu Leu Leu Ser Leu 
1               5                   10                  15      
Ile Ile Thr Leu Ile 
            20      

<210>  17
<211>  126
<212>  DNA
<213>  Artificial Sequence(Artificial Sequence)

<220>
<223>  m4-1BB共刺激结构域


<400>  17
aggaaaaaat tcccccacat attcaagcaa ccatttaaga agaccactgg agcagctcaa        60
gaggaagatg cttgtagctg ccgatgtcca caggaagaag aaggaggagg aggaggctat       120
gagctg                                                                  126

<210>  18
<211>  42
<212>  PRT
<213>  Artificial Sequence(Artificial Sequence)

<220>
<223>  m4-1BB共刺激结构域


<400>  18
Arg Lys Lys Phe Pro His Ile Phe Lys Gln Pro Phe Lys Lys Thr Thr 
1               5                   10                  15      
Gly Ala Ala Gln Glu Glu Asp Ala Cys Ser Cys Arg Cys Pro Gln Glu 
            20                  25                  30          
Glu Glu Gly Gly Gly Gly Gly Tyr Glu Leu 
        35                  40          

<210>  19
<211>  327
<212>  DNA
<213>  Artificial Sequence(Artificial Sequence)

<220>
<223>  mCD3ζ胞内信号传导结构域


<400>  19
agcaggagtg cagagactgc tgccaacctg caggacccca accagctcta caatgagctc        60
aatctagggc gaagagagga atatgacgtc ttggagaaga agcgggctcg ggatccagag       120
atgggaggca aacagcagag gaggaggaac ccccaggaag gcgtatacaa tgcactgcag       180
aaagacaaga tggcagaagc ctacagtgag atcggcacaa aaggcgagag gcggagaggc       240
aaggggcacg atggccttta ccagggtctc agcactgcca ccaaggacac ctatgatgcc       300
ctgcatatgc agaccctggc ccctcgc                                           327

<210>  20
<211>  109
<212>  PRT
<213>  Artificial Sequence(Artificial Sequence)

<220>
<223>  mCD3ζ胞内信号传导结构域


<400>  20
Ser Arg Ser Ala Glu Thr Ala Ala Asn Leu Gln Asp Pro Asn Gln Leu 
1               5                   10                  15      
Tyr Asn Glu Leu Asn Leu Gly Arg Arg Glu Glu Tyr Asp Val Leu Glu 
            20                  25                  30          
Lys Lys Arg Ala Arg Asp Pro Glu Met Gly Gly Lys Gln Gln Arg Arg 
        35                  40                  45              
Arg Asn Pro Gln Glu Gly Val Tyr Asn Ala Leu Gln Lys Asp Lys Met 
    50                  55                  60                  
Ala Glu Ala Tyr Ser Glu Ile Gly Thr Lys Gly Glu Arg Arg Arg Gly 
65                  70                  75                  80  
Lys Gly His Asp Gly Leu Tyr Gln Gly Leu Ser Thr Ala Thr Lys Asp 
                85                  90                  95      
Thr Tyr Asp Ala Leu His Met Gln Thr Leu Ala Pro Arg 
            100                 105                 

<210>  21
<211>  135
<212>  DNA
<213>  Artificial Sequence(Artificial Sequence)

<220>
<223>  mCD8α铰链区


<400>  21
actactacca agccagtgct gcgaactccc tcacctgtgc accctaccgg gacatctcag        60
ccccagagac cagaagattg tcggccccgt ggctcagtga aggggaccgg attggacttc       120
gcctgtgata tttac                                                        135

<210>  22
<211>  45
<212>  PRT
<213>  Artificial Sequence(Artificial Sequence)

<220>
<223>  mCD8α铰链区


<400>  22
Thr Thr Thr Lys Pro Val Leu Arg Thr Pro Ser Pro Val His Pro Thr 
1               5                   10                  15      
Gly Thr Ser Gln Pro Gln Arg Pro Glu Asp Cys Arg Pro Arg Gly Ser 
            20                  25                  30          
Val Lys Gly Thr Gly Leu Asp Phe Ala Cys Asp Ile Tyr 
        35                  40                  45  

<210>  23
<211>  345
<212>  DNA
<213>  Artificial Sequence(Artificial Sequence)

<220>
<223>  hXCL-1


<400>  23
atgagacttc tcatcctggc cctccttggc atctgctctc tcactgcata cattgtggaa        60
ggtgtaggga gtgaagtctc agataagagg acctgtgtga gcctcactac ccagcgactg       120
ccggttagca gaatcaagac ctacaccatc acggaaggct ccttgagagc agtaattttt       180
attaccaaac gtggcctaaa agtctgtgct gatccacaag ccacgtgggt gagagacgtg       240
gtcaggagca tggacaggaa atccaacacc agaaataaca tgatccagac caagccaaca       300
ggaacccagc aatcgaccaa tacagctgtg accctgactg gctag                       345

<210>  24
<211>  114
<212>  PRT
<213>  Artificial Sequence(Artificial Sequence)

<220>
<223>  hXCL-1


<400>  24
Met Arg Leu Leu Ile Leu Ala Leu Leu Gly Ile Cys Ser Leu Thr Ala 
1               5                   10                  15      
Tyr Ile Val Glu Gly Val Gly Ser Glu Val Ser Asp Lys Arg Thr Cys 
            20                  25                  30          
Val Ser Leu Thr Thr Gln Arg Leu Pro Val Ser Arg Ile Lys Thr Tyr 
        35                  40                  45              
Thr Ile Thr Glu Gly Ser Leu Arg Ala Val Ile Phe Ile Thr Lys Arg 
    50                  55                  60                  
Gly Leu Lys Val Cys Ala Asp Pro Gln Ala Thr Trp Val Arg Asp Val 
65                  70                  75                  80  
Val Arg Ser Met Asp Arg Lys Ser Asn Thr Arg Asn Asn Met Ile Gln 
                85                  90                  95      
Thr Lys Pro Thr Gly Thr Gln Gln Ser Thr Asn Thr Ala Val Thr Leu 
            100                 105                 110         
Thr Gly 
        

<210>  25
<211>  345
<212>  DNA
<213>  Artificial Sequence(Artificial Sequence)

<220>
<223>  mXCL-1


<400>  25
atgagacttc tcctcctgac tttcctggga gtctgctgcc tcaccccatg ggttgtggaa        60
ggtgtgggga ctgaagtcct agaagagagt agctgtgtga acttacaaac ccagcggctg       120
ccagttcaaa aaatcaagac ctatatcatc tgggaggggg ccatgagagc tgtaattttt       180
gtcaccaaac gaggactaaa aatttgtgct gatccagaag ccaaatgggt gaaagcagcg       240
atcaagactg tggatggcag ggccagtacc agaaagaaca tggctgaaac tgttcccaca       300
ggagcccaga ggtccaccag cacagcagta accctgactg ggtaa                       345

<210>  26
<211>  114
<212>  PRT
<213>  Artificial Sequence(Artificial Sequence)

<220>
<223>  mXCL-1


<400>  26
Met Arg Leu Leu Leu Leu Thr Phe Leu Gly Val Cys Cys Leu Thr Pro 
1               5                   10                  15      
Trp Val Val Glu Gly Val Gly Thr Glu Val Leu Glu Glu Ser Ser Cys 
            20                  25                  30          
Val Asn Leu Gln Thr Gln Arg Leu Pro Val Gln Lys Ile Lys Thr Tyr 
        35                  40                  45              
Ile Ile Trp Glu Gly Ala Met Arg Ala Val Ile Phe Val Thr Lys Arg 
    50                  55                  60                  
Gly Leu Lys Ile Cys Ala Asp Pro Glu Ala Lys Trp Val Lys Ala Ala 
65                  70                  75                  80  
Ile Lys Thr Val Asp Gly Arg Ala Ser Thr Arg Lys Asn Met Ala Glu 
                85                  90                  95      
Thr Val Pro Thr Gly Ala Gln Arg Ser Thr Ser Thr Ala Val Thr Leu 
            100                 105                 110         
Thr Gly 
        

<210>  27
<211>  54
<212>  DNA
<213>  Artificial Sequence(Artificial Sequence)

<220>
<223>  T2A


<400>  27
gagggcagag gaagtcttct aacatgcggt gacgtggagg agaatcccgg ccct              54

<210>  28
<211>  18
<212>  PRT
<213>  Artificial Sequence(Artificial Sequence)

<220>
<223>  T2A


<400>  28
Glu Gly Arg Gly Ser Leu Leu Thr Cys Gly Asp Val Glu Glu Asn Pro 
1               5                   10                  15      
Gly Pro 
        

<210>  29
<211>  72
<212>  DNA
<213>  Artificial Sequence(Artificial Sequence)

<220>
<223>  mCD8α信号肽


<400>  29
atggcctcac cgttgacccg ctttctgtcg ctgaacctgc tgctgctggg tgagtcgatt        60
atcctgggga gt                                                            72

<210>  30
<211>  24
<212>  PRT
<213>  Artificial Sequence(Artificial Sequence)

<220>
<223>  mCD8α信号肽


<400>  30
Met Ala Ser Pro Leu Thr Arg Phe Leu Ser Leu Asn Leu Leu Leu Leu 
1               5                   10                  15      
Gly Glu Ser Ile Ile Leu Gly Ser 
            20                  

<210>  31
<211>  489
<212>  DNA
<213>  Artificial Sequence(Artificial Sequence)

<220>
<223>  hIL-21前肽


<400>  31
atgagatcca gtcctggcaa catggagagg attgtcatct gtctgatggt catcttcttg        60
gggacactgg tccacaaatc aagctcccaa ggtcaagatc gccacatgat tagaatgcgt       120
caacttatag atattgttga tcagctgaaa aattatgtga atgacttggt ccctgaattt       180
ctgccagctc cagaagatgt agagacaaac tgtgagtggt cagctttttc ctgttttcag       240
aaggcccaac taaagtcagc aaatacagga aacaatgaaa ggataatcaa tgtatcaatt       300
aaaaagctga agaggaaacc accttccaca aatgcaggga gaagacagaa acacagacta       360
acatgccctt catgtgattc ttatgagaaa aaaccaccca aagaattcct agaaagattc       420
aaatcacttc tccaaaagat gattcatcag catctgtcct ctagaacaca cggaagtgaa       480
gattcctga                                                               489

<210>  32
<211>  162
<212>  PRT
<213>  Artificial Sequence(Artificial Sequence)

<220>
<223>  hIL-21前肽


<400>  32
Met Arg Ser Ser Pro Gly Asn Met Glu Arg Ile Val Ile Cys Leu Met 
1               5                   10                  15      
Val Ile Phe Leu Gly Thr Leu Val His Lys Ser Ser Ser Gln Gly Gln 
            20                  25                  30          
Asp Arg His Met Ile Arg Met Arg Gln Leu Ile Asp Ile Val Asp Gln 
        35                  40                  45              
Leu Lys Asn Tyr Val Asn Asp Leu Val Pro Glu Phe Leu Pro Ala Pro 
    50                  55                  60                  
Glu Asp Val Glu Thr Asn Cys Glu Trp Ser Ala Phe Ser Cys Phe Gln 
65                  70                  75                  80  
Lys Ala Gln Leu Lys Ser Ala Asn Thr Gly Asn Asn Glu Arg Ile Ile 
                85                  90                  95      
Asn Val Ser Ile Lys Lys Leu Lys Arg Lys Pro Pro Ser Thr Asn Ala 
            100                 105                 110         
Gly Arg Arg Gln Lys His Arg Leu Thr Cys Pro Ser Cys Asp Ser Tyr 
        115                 120                 125             
Glu Lys Lys Pro Pro Lys Glu Phe Leu Glu Arg Phe Lys Ser Leu Leu 
    130                 135                 140                 
Gln Lys Met Ile His Gln His Leu Ser Ser Arg Thr His Gly Ser Glu 
145                 150                 155                 160 
Asp Ser 
        

<210>  33
<211>  402
<212>  DNA
<213>  Artificial Sequence(Artificial Sequence)

<220>
<223>  hIL-21成熟肽


<400>  33
caaggtcaag atcgccacat gattagaatg cgtcaactta tagatattgt tgatcagctg        60
aaaaattatg tgaatgactt ggtccctgaa tttctgccag ctccagaaga tgtagagaca       120
aactgtgagt ggtcagcttt ttcctgtttt cagaaggccc aactaaagtc agcaaataca       180
ggaaacaatg aaaggataat caatgtatca attaaaaagc tgaagaggaa accaccttcc       240
acaaatgcag ggagaagaca gaaacacaga ctaacatgcc cttcatgtga ttcttatgag       300
aaaaaaccac ccaaagaatt cctagaaaga ttcaaatcac ttctccaaaa gatgattcat       360
cagcatctgt cctctagaac acacggaagt gaagattcct ga                          402

<210>  34
<211>  133
<212>  PRT
<213>  Artificial Sequence(Artificial Sequence)

<220>
<223>  hIL-21成熟肽


<400>  34
Gln Gly Gln Asp Arg His Met Ile Arg Met Arg Gln Leu Ile Asp Ile 
1               5                   10                  15      
Val Asp Gln Leu Lys Asn Tyr Val Asn Asp Leu Val Pro Glu Phe Leu 
            20                  25                  30          
Pro Ala Pro Glu Asp Val Glu Thr Asn Cys Glu Trp Ser Ala Phe Ser 
        35                  40                  45              
Cys Phe Gln Lys Ala Gln Leu Lys Ser Ala Asn Thr Gly Asn Asn Glu 
    50                  55                  60                  
Arg Ile Ile Asn Val Ser Ile Lys Lys Leu Lys Arg Lys Pro Pro Ser 
65                  70                  75                  80  
Thr Asn Ala Gly Arg Arg Gln Lys His Arg Leu Thr Cys Pro Ser Cys 
                85                  90                  95      
Asp Ser Tyr Glu Lys Lys Pro Pro Lys Glu Phe Leu Glu Arg Phe Lys 
            100                 105                 110         
Ser Leu Leu Gln Lys Met Ile His Gln His Leu Ser Ser Arg Thr His 
        115                 120                 125             
Gly Ser Glu Asp Ser 
    130             

<210>  35
<211>  441
<212>  DNA
<213>  Artificial Sequence(Artificial Sequence)

<220>
<223>  mIL-21


<400>  35
atggagagga cccttgtctg tctggtagtc atcttcttgg ggacagtggc ccataaatca        60
agcccccaag ggccagatcg cctcctgatt agacttcgtc accttattga cattgttgaa       120
cagctgaaaa tctatgaaaa tgacttggat cctgaacttc tatcagctcc acaagatgta       180
aaggggcact gtgagcatgc agcttttgcc tgttttcaga aggccaaact caagccatca       240
aaccctggaa acaataagac attcatcatt gacctcgtgg cccagctcag gaggaggctg       300
cctgccagga ggggaggaaa gaaacagaag cacatagcta aatgcccttc ctgtgattcg       360
tatgagaaaa ggacacccaa agaattccta gaaagactaa aatggctcct tcaaaagatg       420
attcatcagc atctctccta g                                                 441

<210>  36
<211>  146
<212>  PRT
<213>  Artificial Sequence(Artificial Sequence)

<220>
<223>  mIL-21


<400>  36
Met Glu Arg Thr Leu Val Cys Leu Val Val Ile Phe Leu Gly Thr Val 
1               5                   10                  15      
Ala His Lys Ser Ser Pro Gln Gly Pro Asp Arg Leu Leu Ile Arg Leu 
            20                  25                  30          
Arg His Leu Ile Asp Ile Val Glu Gln Leu Lys Ile Tyr Glu Asn Asp 
        35                  40                  45              
Leu Asp Pro Glu Leu Leu Ser Ala Pro Gln Asp Val Lys Gly His Cys 
    50                  55                  60                  
Glu His Ala Ala Phe Ala Cys Phe Gln Lys Ala Lys Leu Lys Pro Ser 
65                  70                  75                  80  
Asn Pro Gly Asn Asn Lys Thr Phe Ile Ile Asp Leu Val Ala Gln Leu 
                85                  90                  95      
Arg Arg Arg Leu Pro Ala Arg Arg Gly Gly Lys Lys Gln Lys His Ile 
            100                 105                 110         
Ala Lys Cys Pro Ser Cys Asp Ser Tyr Glu Lys Arg Thr Pro Lys Glu 
        115                 120                 125             
Phe Leu Glu Arg Leu Lys Trp Leu Leu Gln Lys Met Ile His Gln His 
    130                 135                 140                 
Leu Ser 
145     

<210>  637
<211>  345
<212>  DNA
<213>  Artificial Sequence(Artificial Sequence)

<220>
<223>  hXCL2


<400>  637
atgagacttc tcatcctggc cctccttggc atctgctctc tcactgcata cattgtggaa        60
ggtgtaggga gtgaagtctc acataggagg acctgtgtga gcctcactac ccagcgactg       120
ccagttagca gaatcaagac ctacaccatc acggaaggct ccttgagagc agtaattttt       180
attaccaaac gtggcctaaa agtctgtgct gatccacaag ccacgtgggt gagagacgtg       240
gtcaggagca tggacaggaa atccaacacc agaaataaca tgatccagac caagccaaca       300
ggaacccagc aatcgaccaa tacagctgtg accctgactg gctag                       345

<210>  38
<211>  114
<212>  PRT
<213>  Artificial Sequence(Artificial Sequence)

<220>
<223>  hXCL2


<400>  38
Met Arg Leu Leu Ile Leu Ala Leu Leu Gly Ile Cys Ser Leu Thr Ala 
1               5                   10                  15      
Tyr Ile Val Glu Gly Val Gly Ser Glu Val Ser His Arg Arg Thr Cys 
            20                  25                  30          
Val Ser Leu Thr Thr Gln Arg Leu Pro Val Ser Arg Ile Lys Thr Tyr 
        35                  40                  45              
Thr Ile Thr Glu Gly Ser Leu Arg Ala Val Ile Phe Ile Thr Lys Arg 
    50                  55                  60                  
Gly Leu Lys Val Cys Ala Asp Pro Gln Ala Thr Trp Val Arg Asp Val 
65                  70                  75                  80  
Val Arg Ser Met Asp Arg Lys Ser Asn Thr Arg Asn Asn Met Ile Gln 
                85                  90                  95      
Thr Lys Pro Thr Gly Thr Gln Gln Ser Thr Asn Thr Ala Val Thr Leu 
            100                 105                 110         
Thr Gly 
        

<210>  39
<211>  660
<212>  DNA
<213>  Artificial Sequence(Artificial Sequence)

<220>
<223>  hIL12


<400>  39
atgtgtccag cgcgcagcct cctccttgtg gctaccctgg tcctcctgga ccacctcagt        60
ttggccagaa acctccccgt ggccactcca gacccaggaa tgttcccatg ccttcaccac       120
tcccaaaacc tgctgagggc cgtcagcaac atgctccaga aggccagaca aactctagaa       180
ttttaccctt gcacttctga agagattgat catgaagata tcacaaaaga taaaaccagc       240
acagtggagg cctgtttacc attggaatta accaagaatg agagttgcct aaattccaga       300
gagacctctt tcataactaa tgggagttgc ctggcctcca gaaagacctc ttttatgatg       360
gccctgtgcc ttagtagtat ttatgaagac ttgaagatgt accaggtgga gttcaagacc       420
atgaatgcaa agcttctgat ggatcctaag aggcagatct ttctagatca aaacatgctg       480
gcagttattg atgagctgat gcaggccctg aatttcaaca gtgagactgt gccacaaaaa       540
tcctcccttg aagaaccgga tttttataaa actaaaatca agctctgcat acttcttcat       600
gctttcagaa ttcgggcagt gactattgac agagtgacga gctatctgaa tgcttcctaa       660

<210>  40
<211>  219
<212>  PRT
<213>  Artificial Sequence(Artificial Sequence)

<220>
<223>  hIL12


<400>  40
Met Cys Pro Ala Arg Ser Leu Leu Leu Val Ala Thr Leu Val Leu Leu 
1               5                   10                  15      
Asp His Leu Ser Leu Ala Arg Asn Leu Pro Val Ala Thr Pro Asp Pro 
            20                  25                  30          
Gly Met Phe Pro Cys Leu His His Ser Gln Asn Leu Leu Arg Ala Val 
        35                  40                  45              
Ser Asn Met Leu Gln Lys Ala Arg Gln Thr Leu Glu Phe Tyr Pro Cys 
    50                  55                  60                  
Thr Ser Glu Glu Ile Asp His Glu Asp Ile Thr Lys Asp Lys Thr Ser 
65                  70                  75                  80  
Thr Val Glu Ala Cys Leu Pro Leu Glu Leu Thr Lys Asn Glu Ser Cys 
                85                  90                  95      
Leu Asn Ser Arg Glu Thr Ser Phe Ile Thr Asn Gly Ser Cys Leu Ala 
            100                 105                 110         
Ser Arg Lys Thr Ser Phe Met Met Ala Leu Cys Leu Ser Ser Ile Tyr 
        115                 120                 125             
Glu Asp Leu Lys Met Tyr Gln Val Glu Phe Lys Thr Met Asn Ala Lys 
    130                 135                 140                 
Leu Leu Met Asp Pro Lys Arg Gln Ile Phe Leu Asp Gln Asn Met Leu 
145                 150                 155                 160 
Ala Val Ile Asp Glu Leu Met Gln Ala Leu Asn Phe Asn Ser Glu Thr 
                165                 170                 175     
Val Pro Gln Lys Ser Ser Leu Glu Glu Pro Asp Phe Tyr Lys Thr Lys 
            180                 185                 190         
Ile Lys Leu Cys Ile Leu Leu His Ala Phe Arg Ile Arg Ala Val Thr 
        195                 200                 205             
Ile Asp Arg Val Thr Ser Tyr Leu Asn Ala Ser 
    210                 215                 

<210>  41
<211>  648
<212>  DNA
<213>  Artificial Sequence(Artificial Sequence)

<220>
<223>  mIL12


<400>  41
atgtgtcaat cacgctacct cctctttttg gccacccttg ccctcctaaa ccacctcagt        60
ttggccaggg tcattccagt ctctggacct gccaggtgtc ttagccagtc ccgaaacctg       120
ctgaagacca cagatgacat ggtgaagacg gccagagaaa aactgaaaca ttattcctgc       180
actgctgaag acatcgatca tgaagacatc acacgggacc aaaccagcac attgaagacc       240
tgtttaccac tggaactaca caagaacgag agttgcctgg ctactagaga gacttcttcc       300
acaacaagag ggagctgcct gcccccacag aagacgtctt tgatgatgac cctgtgcctt       360
ggtagcatct atgaggactt gaagatgtac cagacagagt tccaggccat caacgcagca       420
cttcagaatc acaaccatca gcagatcatt ctagacaagg gcatgctggt ggccatcgat       480
gagctgatgc agtctctgaa tcataatggc gagactctgc gccagaaacc tcctgtggga       540
gaagcagacc cttacagagt gaaaatgaag ctctgcatcc tgcttcacgc cttcagcacc       600
cgcgtcgtga ccatcaacag ggtgatgggc tatctgagct ccgcctga                    648

<210>  42
<211>  215
<212>  PRT
<213>  Artificial Sequence(Artificial Sequence)

<220>
<223>  mIL12


<400>  42
Met Cys Gln Ser Arg Tyr Leu Leu Phe Leu Ala Thr Leu Ala Leu Leu 
1               5                   10                  15      
Asn His Leu Ser Leu Ala Arg Val Ile Pro Val Ser Gly Pro Ala Arg 
            20                  25                  30          
Cys Leu Ser Gln Ser Arg Asn Leu Leu Lys Thr Thr Asp Asp Met Val 
        35                  40                  45              
Lys Thr Ala Arg Glu Lys Leu Lys His Tyr Ser Cys Thr Ala Glu Asp 
    50                  55                  60                  
Ile Asp His Glu Asp Ile Thr Arg Asp Gln Thr Ser Thr Leu Lys Thr 
65                  70                  75                  80  
Cys Leu Pro Leu Glu Leu His Lys Asn Glu Ser Cys Leu Ala Thr Arg 
                85                  90                  95      
Glu Thr Ser Ser Thr Thr Arg Gly Ser Cys Leu Pro Pro Gln Lys Thr 
            100                 105                 110         
Ser Leu Met Met Thr Leu Cys Leu Gly Ser Ile Tyr Glu Asp Leu Lys 
        115                 120                 125             
Met Tyr Gln Thr Glu Phe Gln Ala Ile Asn Ala Ala Leu Gln Asn His 
    130                 135                 140                 
Asn His Gln Gln Ile Ile Leu Asp Lys Gly Met Leu Val Ala Ile Asp 
145                 150                 155                 160 
Glu Leu Met Gln Ser Leu Asn His Asn Gly Glu Thr Leu Arg Gln Lys 
                165                 170                 175     
Pro Pro Val Gly Glu Ala Asp Pro Tyr Arg Val Lys Met Lys Leu Cys 
            180                 185                 190         
Ile Leu Leu His Ala Phe Ser Thr Arg Val Val Thr Ile Asn Arg Val 
        195                 200                 205             
Met Gly Tyr Leu Ser Ser Ala 
    210                 215 

<210>  43
<211>  582
<212>  DNA
<213>  Artificial Sequence(Artificial Sequence)

<220>
<223>  hIL18


<400>  43
atggctgctg aaccagtaga agacaattgc atcaactttg tggcaatgaa atttattgac        60
aatacgcttt actttatagc tgaagatgat gaaaacctgg aatcagatta ctttggcaag       120
cttgaatcta aattatcagt cataagaaat ttgaatgacc aagttctctt cattgaccaa       180
ggaaatcggc ctctatttga agatatgact gattctgact gtagagataa tgcaccccgg       240
accatattta ttataagtat gtataaagat agccagccta gaggtatggc tgtaactatc       300
tctgtgaagt gtgagaaaat ttcaactctc tcctgtgaga acaaaattat ttcctttaag       360
gaaatgaatc ctcctgataa catcaaggat acaaaaagtg acatcatatt ctttcagaga       420
agtgtcccag gacatgataa taagatgcaa tttgaatctt catcatacga aggatacttt       480
ctagcttgtg aaaaagagag agaccttttt aaactcattt tgaaaaaaga ggatgaattg       540
ggggatagat ctataatgtt cactgttcaa aacgaagact ag                          582

<210>  44
<211>  193
<212>  PRT
<213>  Artificial Sequence(Artificial Sequence)

<220>
<223>  hIL18


<400>  44
Met Ala Ala Glu Pro Val Glu Asp Asn Cys Ile Asn Phe Val Ala Met 
1               5                   10                  15      
Lys Phe Ile Asp Asn Thr Leu Tyr Phe Ile Ala Glu Asp Asp Glu Asn 
            20                  25                  30          
Leu Glu Ser Asp Tyr Phe Gly Lys Leu Glu Ser Lys Leu Ser Val Ile 
        35                  40                  45              
Arg Asn Leu Asn Asp Gln Val Leu Phe Ile Asp Gln Gly Asn Arg Pro 
    50                  55                  60                  
Leu Phe Glu Asp Met Thr Asp Ser Asp Cys Arg Asp Asn Ala Pro Arg 
65                  70                  75                  80  
Thr Ile Phe Ile Ile Ser Met Tyr Lys Asp Ser Gln Pro Arg Gly Met 
                85                  90                  95      
Ala Val Thr Ile Ser Val Lys Cys Glu Lys Ile Ser Thr Leu Ser Cys 
            100                 105                 110         
Glu Asn Lys Ile Ile Ser Phe Lys Glu Met Asn Pro Pro Asp Asn Ile 
        115                 120                 125             
Lys Asp Thr Lys Ser Asp Ile Ile Phe Phe Gln Arg Ser Val Pro Gly 
    130                 135                 140                 
His Asp Asn Lys Met Gln Phe Glu Ser Ser Ser Tyr Glu Gly Tyr Phe 
145                 150                 155                 160 
Leu Ala Cys Glu Lys Glu Arg Asp Leu Phe Lys Leu Ile Leu Lys Lys 
                165                 170                 175     
Glu Asp Glu Leu Gly Asp Arg Ser Ile Met Phe Thr Val Gln Asn Glu 
            180                 185                 190         
Asp 
    

<210>  45
<211>  579
<212>  DNA
<213>  Artificial Sequence(Artificial Sequence)

<220>
<223>  mIL18


<400>  45
atggctgcca tgtcagaaga ctcttgcgtc aacttcaagg aaatgatgtt tattgacaac        60
acgctttact ttatacctga agaaaatgga gacctggaat cagacaactt tggccgactt       120
cactgtacaa ccgcagtaat acggaatata aatgaccaag ttctcttcgt tgacaaaaga       180
cagcctgtgt tcgaggatat gactgatatt gatcaaagtg ccagtgaacc ccagaccaga       240
ctgataatat acatgtacaa agacagtgaa gtaagaggac tggctgtgac cctctctgtg       300
aaggatagta aaatgtctac cctctcctgt aagaacaaga tcatttcctt tgaggaaatg       360
gatccacctg aaaatattga tgatatacaa agtgatctca tattctttca gaaacgtgtt       420
ccaggacaca acaagatgga gtttgaatct tcactgtatg aaggacactt tcttgcttgc       480
caaaaggaag atgatgcttt caaactcatt ctgaaaaaaa aggatgaaaa tggggataaa       540
tctgtaatgt tcactctcac taacttacat caaagttag                              579

<210>  46
<211>  192
<212>  PRT
<213>  Artificial Sequence(Artificial Sequence)

<220>
<223>  mIL18


<400>  46
Met Ala Ala Met Ser Glu Asp Ser Cys Val Asn Phe Lys Glu Met Met 
1               5                   10                  15      
Phe Ile Asp Asn Thr Leu Tyr Phe Ile Pro Glu Glu Asn Gly Asp Leu 
            20                  25                  30          
Glu Ser Asp Asn Phe Gly Arg Leu His Cys Thr Thr Ala Val Ile Arg 
        35                  40                  45              
Asn Ile Asn Asp Gln Val Leu Phe Val Asp Lys Arg Gln Pro Val Phe 
    50                  55                  60                  
Glu Asp Met Thr Asp Ile Asp Gln Ser Ala Ser Glu Pro Gln Thr Arg 
65                  70                  75                  80  
Leu Ile Ile Tyr Met Tyr Lys Asp Ser Glu Val Arg Gly Leu Ala Val 
                85                  90                  95      
Thr Leu Ser Val Lys Asp Ser Lys Met Ser Thr Leu Ser Cys Lys Asn 
            100                 105                 110         
Lys Ile Ile Ser Phe Glu Glu Met Asp Pro Pro Glu Asn Ile Asp Asp 
        115                 120                 125             
Ile Gln Ser Asp Leu Ile Phe Phe Gln Lys Arg Val Pro Gly His Asn 
    130                 135                 140                 
Lys Met Glu Phe Glu Ser Ser Leu Tyr Glu Gly His Phe Leu Ala Cys 
145                 150                 155                 160 
Gln Lys Glu Asp Asp Ala Phe Lys Leu Ile Leu Lys Lys Lys Asp Glu 
                165                 170                 175     
Asn Gly Asp Lys Ser Val Met Phe Thr Leu Thr Asn Leu His Gln Ser 
            180                 185                 190         

<210>  47
<211>  570
<212>  DNA
<213>  Artificial Sequence(Artificial Sequence)

<220>
<223>  hIL23


<400>  47
atgctgggga gcagagctgt aatgctgctg ttgctgctgc cctggacagc tcagggcaga        60
gctgtgcctg ggggcagcag ccctgcctgg actcagtgcc agcagctttc acagaagctc       120
tgcacactgg cctggagtgc acatccacta gtgggacaca tggatctaag agaagaggga       180
gatgaagaga ctacaaatga tgttccccat atccagtgtg gagatggctg tgacccccaa       240
ggactcaggg acaacagtca gttctgcttg caaaggatcc accagggtct gattttttat       300
gagaagctgc taggatcgga tattttcaca ggggagcctt ctctgctccc tgatagccct       360
gtggcgcagc ttcatgcctc cctactgggc ctcagccaac tcctgcagcc tgagggtcac       420
cactgggaga ctcagcagat tccaagcctc agtcccagcc agccatggca gcgtctcctt       480
ctccgcttca aaatccttcg cagcctccag gcctttgtgg ctgtagccgc ccgggtcttt       540
gcccatggag cagcaaccct gagtccctaa                                        570

<210>  48
<211>  189
<212>  PRT
<213>  Artificial Sequence(Artificial Sequence)

<220>
<223>  hIL23


<400>  48
Met Leu Gly Ser Arg Ala Val Met Leu Leu Leu Leu Leu Pro Trp Thr 
1               5                   10                  15      
Ala Gln Gly Arg Ala Val Pro Gly Gly Ser Ser Pro Ala Trp Thr Gln 
            20                  25                  30          
Cys Gln Gln Leu Ser Gln Lys Leu Cys Thr Leu Ala Trp Ser Ala His 
        35                  40                  45              
Pro Leu Val Gly His Met Asp Leu Arg Glu Glu Gly Asp Glu Glu Thr 
    50                  55                  60                  
Thr Asn Asp Val Pro His Ile Gln Cys Gly Asp Gly Cys Asp Pro Gln 
65                  70                  75                  80  
Gly Leu Arg Asp Asn Ser Gln Phe Cys Leu Gln Arg Ile His Gln Gly 
                85                  90                  95      
Leu Ile Phe Tyr Glu Lys Leu Leu Gly Ser Asp Ile Phe Thr Gly Glu 
            100                 105                 110         
Pro Ser Leu Leu Pro Asp Ser Pro Val Ala Gln Leu His Ala Ser Leu 
        115                 120                 125             
Leu Gly Leu Ser Gln Leu Leu Gln Pro Glu Gly His His Trp Glu Thr 
    130                 135                 140                 
Gln Gln Ile Pro Ser Leu Ser Pro Ser Gln Pro Trp Gln Arg Leu Leu 
145                 150                 155                 160 
Leu Arg Phe Lys Ile Leu Arg Ser Leu Gln Ala Phe Val Ala Val Ala 
                165                 170                 175     
Ala Arg Val Phe Ala His Gly Ala Ala Thr Leu Ser Pro 
            180                 185                 

<210>  49
<211>  591
<212>  DNA
<213>  Artificial Sequence(Artificial Sequence)

<220>
<223>  mIL23


<400>  49
atgctggatt gcagagcagt aataatgcta tggctgttgc cctgggtcac tcagggcctg        60
gctgtgccta ggagtagcag tcctgactgg gctcagtgcc agcagctctc tcggaatctc       120
tgcatgctag cctggaacgc acatgcacca gcgggacata tgaatctact aagagaagaa       180
gaggatgaag agactaaaaa taatgtgccc cgtatccagt gtgaagatgg ttgtgaccca       240
caaggactca aggacaacag ccagttctgc ttgcaaagga tccgccaagg tctggctttt       300
tataagcacc tgcttgactc tgacatcttc aaaggggagc ctgctctact ccctgatagc       360
cccatggagc aacttcacac ctccctacta ggactcagcc aactcctcca gccagaggat       420
cacccccggg agacccaaca gatgcccagc ctgagttcta gtcagcagtg gcagcgcccc       480
cttctccgtt ccaagatcct tcgaagcctc caggcctttt tggccatagc tgcccgggtc       540
tttgcccacg gagcagcaac tctgactgag cccttagtgc caacagctta a                591

<210>  50
<211>  196
<212>  PRT
<213>  Artificial Sequence(Artificial Sequence)

<220>
<223>  mIL23


<400>  50
Met Leu Asp Cys Arg Ala Val Ile Met Leu Trp Leu Leu Pro Trp Val 
1               5                   10                  15      
Thr Gln Gly Leu Ala Val Pro Arg Ser Ser Ser Pro Asp Trp Ala Gln 
            20                  25                  30          
Cys Gln Gln Leu Ser Arg Asn Leu Cys Met Leu Ala Trp Asn Ala His 
        35                  40                  45              
Ala Pro Ala Gly His Met Asn Leu Leu Arg Glu Glu Glu Asp Glu Glu 
    50                  55                  60                  
Thr Lys Asn Asn Val Pro Arg Ile Gln Cys Glu Asp Gly Cys Asp Pro 
65                  70                  75                  80  
Gln Gly Leu Lys Asp Asn Ser Gln Phe Cys Leu Gln Arg Ile Arg Gln 
                85                  90                  95      
Gly Leu Ala Phe Tyr Lys His Leu Leu Asp Ser Asp Ile Phe Lys Gly 
            100                 105                 110         
Glu Pro Ala Leu Leu Pro Asp Ser Pro Met Glu Gln Leu His Thr Ser 
        115                 120                 125             
Leu Leu Gly Leu Ser Gln Leu Leu Gln Pro Glu Asp His Pro Arg Glu 
    130                 135                 140                 
Thr Gln Gln Met Pro Ser Leu Ser Ser Ser Gln Gln Trp Gln Arg Pro 
145                 150                 155                 160 
Leu Leu Arg Ser Lys Ile Leu Arg Ser Leu Gln Ala Phe Leu Ala Ile 
                165                 170                 175     
Ala Ala Arg Val Phe Ala His Gly Ala Ala Thr Leu Thr Glu Pro Leu 
            180                 185                 190         
Val Pro Thr Ala 
        195     

<210>  51
<211>  813
<212>  DNA
<213>  Artificial Sequence(Artificial Sequence)

<220>
<223>  hIL33


<400>  51
atgaagccta aaatgaagta ttcaaccaac aaaatttcca cagcaaagtg gaagaacaca        60
gcaagcaaag ccttgtgttt caagctggga aaatcccaac agaaggccaa agaagtttgc       120
cccatgtact ttatgaagct ccgctctggc cttatgataa aaaaggaggc ctgttacttt       180
aggagagaaa ccaccaaaag gccttcactg aaaacaggta gaaagcacaa aagacatctg       240
gtactcgctg cctgtcaaca gcagtctact gtggagtgct ttgcctttgg tatatcaggg       300
gtccagaaat atactagagc acttcatgat tcaagtatca caggaatttc acctattaca       360
gagtatcttg cttctctaag cacatacaat gatcaatcca ttacttttgc tttggaggat       420
gaaagttatg agatatatgt tgaagacttg aaaaaagatg aaaagaaaga taaggtgtta       480
ctgagttact atgagtctca acacccctca aatgaatcag gtgacggtgt tgatggtaag       540
atgttaatgg taaccctgag tcctacaaaa gacttctggt tgcatgccaa caacaaggaa       600
cactctgtgg agctccataa gtgtgaaaaa ccactgccag accaggcctt ctttgtcctt       660
cataatatgc actccaactg tgtttcattt gaatgcaaga ctgatcctgg agtgtttata       720
ggtgtaaagg ataatcatct tgctctgatt aaagtagact cttctgagaa tttgtgtact       780
gaaaatatct tgtttaagct ctctgaaact tag                                    813

<210>  52
<211>  270
<212>  PRT
<213>  Artificial Sequence(Artificial Sequence)

<220>
<223>  hIL33


<400>  52
Met Lys Pro Lys Met Lys Tyr Ser Thr Asn Lys Ile Ser Thr Ala Lys 
1               5                   10                  15      
Trp Lys Asn Thr Ala Ser Lys Ala Leu Cys Phe Lys Leu Gly Lys Ser 
            20                  25                  30          
Gln Gln Lys Ala Lys Glu Val Cys Pro Met Tyr Phe Met Lys Leu Arg 
        35                  40                  45              
Ser Gly Leu Met Ile Lys Lys Glu Ala Cys Tyr Phe Arg Arg Glu Thr 
    50                  55                  60                  
Thr Lys Arg Pro Ser Leu Lys Thr Gly Arg Lys His Lys Arg His Leu 
65                  70                  75                  80  
Val Leu Ala Ala Cys Gln Gln Gln Ser Thr Val Glu Cys Phe Ala Phe 
                85                  90                  95      
Gly Ile Ser Gly Val Gln Lys Tyr Thr Arg Ala Leu His Asp Ser Ser 
            100                 105                 110         
Ile Thr Gly Ile Ser Pro Ile Thr Glu Tyr Leu Ala Ser Leu Ser Thr 
        115                 120                 125             
Tyr Asn Asp Gln Ser Ile Thr Phe Ala Leu Glu Asp Glu Ser Tyr Glu 
    130                 135                 140                 
Ile Tyr Val Glu Asp Leu Lys Lys Asp Glu Lys Lys Asp Lys Val Leu 
145                 150                 155                 160 
Leu Ser Tyr Tyr Glu Ser Gln His Pro Ser Asn Glu Ser Gly Asp Gly 
                165                 170                 175     
Val Asp Gly Lys Met Leu Met Val Thr Leu Ser Pro Thr Lys Asp Phe 
            180                 185                 190         
Trp Leu His Ala Asn Asn Lys Glu His Ser Val Glu Leu His Lys Cys 
        195                 200                 205             
Glu Lys Pro Leu Pro Asp Gln Ala Phe Phe Val Leu His Asn Met His 
    210                 215                 220                 
Ser Asn Cys Val Ser Phe Glu Cys Lys Thr Asp Pro Gly Val Phe Ile 
225                 230                 235                 240 
Gly Val Lys Asp Asn His Leu Ala Leu Ile Lys Val Asp Ser Ser Glu 
                245                 250                 255     
Asn Leu Cys Thr Glu Asn Ile Leu Phe Lys Leu Ser Glu Thr 
            260                 265                 270 

<210>  53
<211>  801
<212>  DNA
<213>  Artificial Sequence(Artificial Sequence)

<220>
<223>  mIL33


<400>  53
atgagaccta gaatgaagta ttccaactcc aagatttccc cggcaaagtt cagcagcacc        60
gcaggcgaag ccctggtccc gccttgcaaa ataagaagat cccaacagaa gaccaaagaa       120
ttctgccatg tctactgcat gagactccgt tctggcctca ccataagaaa ggagactagt       180
tattttagga aagaacccac gaaaagatat tcactaaaat cgggtaccaa gcatgaagag       240
aacttctctg cctatccacg ggattctagg aagagatcct tgcttggcag tatccaagca       300
tttgctgcgt ctgttgacac attgagcatc caaggaactt cacttttaac acagtctcct       360
gcctccctga gtacatacaa tgaccaatct gttagttttg ttttggagaa tggatgttat       420
gtgatcaatg ttgacgactc tggaaaagac caagagcaag accaggtgct actacgctac       480
tatgagtctc cctgtcctgc aagtcaatca ggcgacggtg tggatgggaa gaagctgatg       540
gtgaacatga gtcccatcaa agacacagac atctggctgc atgccaacga caaggactac       600
tccgtggagc ttcaaagggg tgacgtctcg cctccggaac aggccttctt cgtccttcac       660
aaaaagtcct cggactttgt ttcatttgaa tgcaagaatc ttcctggcac ttacatagga       720
gtaaaagata accagctggc tctagtggag gagaaagatg agagctgcaa caatattatg       780
tttaagctct cgaaaatcta a                                                 801

<210>  54
<211>  266
<212>  PRT
<213>  Artificial Sequence(Artificial Sequence)

<220>
<223>  mIL33


<400>  54
Met Arg Pro Arg Met Lys Tyr Ser Asn Ser Lys Ile Ser Pro Ala Lys 
1               5                   10                  15      
Phe Ser Ser Thr Ala Gly Glu Ala Leu Val Pro Pro Cys Lys Ile Arg 
            20                  25                  30          
Arg Ser Gln Gln Lys Thr Lys Glu Phe Cys His Val Tyr Cys Met Arg 
        35                  40                  45              
Leu Arg Ser Gly Leu Thr Ile Arg Lys Glu Thr Ser Tyr Phe Arg Lys 
    50                  55                  60                  
Glu Pro Thr Lys Arg Tyr Ser Leu Lys Ser Gly Thr Lys His Glu Glu 
65                  70                  75                  80  
Asn Phe Ser Ala Tyr Pro Arg Asp Ser Arg Lys Arg Ser Leu Leu Gly 
                85                  90                  95      
Ser Ile Gln Ala Phe Ala Ala Ser Val Asp Thr Leu Ser Ile Gln Gly 
            100                 105                 110         
Thr Ser Leu Leu Thr Gln Ser Pro Ala Ser Leu Ser Thr Tyr Asn Asp 
        115                 120                 125             
Gln Ser Val Ser Phe Val Leu Glu Asn Gly Cys Tyr Val Ile Asn Val 
    130                 135                 140                 
Asp Asp Ser Gly Lys Asp Gln Glu Gln Asp Gln Val Leu Leu Arg Tyr 
145                 150                 155                 160 
Tyr Glu Ser Pro Cys Pro Ala Ser Gln Ser Gly Asp Gly Val Asp Gly 
                165                 170                 175     
Lys Lys Leu Met Val Asn Met Ser Pro Ile Lys Asp Thr Asp Ile Trp 
            180                 185                 190         
Leu His Ala Asn Asp Lys Asp Tyr Ser Val Glu Leu Gln Arg Gly Asp 
        195                 200                 205             
Val Ser Pro Pro Glu Gln Ala Phe Phe Val Leu His Lys Lys Ser Ser 
    210                 215                 220                 
Asp Phe Val Ser Phe Glu Cys Lys Asn Leu Pro Gly Thr Tyr Ile Gly 
225                 230                 235                 240 
Val Lys Asp Asn Gln Leu Ala Leu Val Glu Glu Lys Asp Glu Ser Cys 
                245                 250                 255     
Asn Asn Ile Met Phe Lys Leu Ser Lys Ile 
            260                 265     

<210>  55
<211>  176
<212>  PRT
<213>  Artificial Sequence(Artificial Sequence)

<220>
<223>  hIL33-95-270


<400>  55
Ala Phe Gly Ile Ser Gly Val Gln Lys Tyr Thr Arg Ala Leu His Asp 
1               5                   10                  15      
Ser Ser Ile Thr Gly Ile Ser Pro Ile Thr Glu Tyr Leu Ala Ser Leu 
            20                  25                  30          
Ser Thr Tyr Asn Asp Gln Ser Ile Thr Phe Ala Leu Glu Asp Glu Ser 
        35                  40                  45              
Tyr Glu Ile Tyr Val Glu Asp Leu Lys Lys Asp Glu Lys Lys Asp Lys 
    50                  55                  60                  
Val Leu Leu Ser Tyr Tyr Glu Ser Gln His Pro Ser Asn Glu Ser Gly 
65                  70                  75                  80  
Asp Gly Val Asp Gly Lys Met Leu Met Val Thr Leu Ser Pro Thr Lys 
                85                  90                  95      
Asp Phe Trp Leu His Ala Asn Asn Lys Glu His Ser Val Glu Leu His 
            100                 105                 110         
Lys Cys Glu Lys Pro Leu Pro Asp Gln Ala Phe Phe Val Leu His Asn 
        115                 120                 125             
Met His Ser Asn Cys Val Ser Phe Glu Cys Lys Thr Asp Pro Gly Val 
    130                 135                 140                 
Phe Ile Gly Val Lys Asp Asn His Leu Ala Leu Ile Lys Val Asp Ser 
145                 150                 155                 160 
Ser Glu Asn Leu Cys Thr Glu Asn Ile Leu Phe Lys Leu Ser Glu Thr 
                165                 170                 175     

<210>  56
<211>  172
<212>  PRT
<213>  Artificial Sequence(Artificial Sequence)

<220>
<223>  hIL33-99-270


<400>  56
Ser Gly Val Gln Lys Tyr Thr Arg Ala Leu His Asp Ser Ser Ile Thr 
1               5                   10                  15      
Gly Ile Ser Pro Ile Thr Glu Tyr Leu Ala Ser Leu Ser Thr Tyr Asn 
            20                  25                  30          
Asp Gln Ser Ile Thr Phe Ala Leu Glu Asp Glu Ser Tyr Glu Ile Tyr 
        35                  40                  45              
Val Glu Asp Leu Lys Lys Asp Glu Lys Lys Asp Lys Val Leu Leu Ser 
    50                  55                  60                  
Tyr Tyr Glu Ser Gln His Pro Ser Asn Glu Ser Gly Asp Gly Val Asp 
65                  70                  75                  80  
Gly Lys Met Leu Met Val Thr Leu Ser Pro Thr Lys Asp Phe Trp Leu 
                85                  90                  95      
His Ala Asn Asn Lys Glu His Ser Val Glu Leu His Lys Cys Glu Lys 
            100                 105                 110         
Pro Leu Pro Asp Gln Ala Phe Phe Val Leu His Asn Met His Ser Asn 
        115                 120                 125             
Cys Val Ser Phe Glu Cys Lys Thr Asp Pro Gly Val Phe Ile Gly Val 
    130                 135                 140                 
Lys Asp Asn His Leu Ala Leu Ile Lys Val Asp Ser Ser Glu Asn Leu 
145                 150                 155                 160 
Cys Thr Glu Asn Ile Leu Phe Lys Leu Ser Glu Thr 
                165                 170         

<210>  57
<211>  162
<212>  PRT
<213>  Artificial Sequence(Artificial Sequence)

<220>
<223>  hIL33-109-270


<400>  57
His Asp Ser Ser Ile Thr Gly Ile Ser Pro Ile Thr Glu Tyr Leu Ala 
1               5                   10                  15      
Ser Leu Ser Thr Tyr Asn Asp Gln Ser Ile Thr Phe Ala Leu Glu Asp 
            20                  25                  30          
Glu Ser Tyr Glu Ile Tyr Val Glu Asp Leu Lys Lys Asp Glu Lys Lys 
        35                  40                  45              
Asp Lys Val Leu Leu Ser Tyr Tyr Glu Ser Gln His Pro Ser Asn Glu 
    50                  55                  60                  
Ser Gly Asp Gly Val Asp Gly Lys Met Leu Met Val Thr Leu Ser Pro 
65                  70                  75                  80  
Thr Lys Asp Phe Trp Leu His Ala Asn Asn Lys Glu His Ser Val Glu 
                85                  90                  95      
Leu His Lys Cys Glu Lys Pro Leu Pro Asp Gln Ala Phe Phe Val Leu 
            100                 105                 110         
His Asn Met His Ser Asn Cys Val Ser Phe Glu Cys Lys Thr Asp Pro 
        115                 120                 125             
Gly Val Phe Ile Gly Val Lys Asp Asn His Leu Ala Leu Ile Lys Val 
    130                 135                 140                 
Asp Ser Ser Glu Asn Leu Cys Thr Glu Asn Ile Leu Phe Lys Leu Ser 
145                 150                 155                 160 
Glu Thr 
        

<210>  58
<211>  531
<212>  DNA
<213>  Artificial Sequence(Artificial Sequence)

<220>
<223>  hIL33-95-270


<400>  58
gcctttggta tatcaggggt ccagaaatat actagagcac ttcatgattc aagtatcaca        60
ggaatttcac ctattacaga gtatcttgct tctctaagca catacaatga tcaatccatt       120
acttttgctt tggaggatga aagttatgag atatatgttg aagacttgaa aaaagatgaa       180
aagaaagata aggtgttact gagttactat gagtctcaac acccctcaaa tgaatcaggt       240
gacggtgttg atggtaagat gttaatggta accctgagtc ctacaaaaga cttctggttg       300
catgccaaca acaaggaaca ctctgtggag ctccataagt gtgaaaaacc actgccagac       360
caggccttct ttgtccttca taatatgcac tccaactgtg tttcatttga atgcaagact       420
gatcctggag tgtttatagg tgtaaaggat aatcatcttg ctctgattaa agtagactct       480
tctgagaatt tgtgtactga aaatatcttg tttaagctct ctgaaactta g                531

<210>  59
<211>  519
<212>  DNA
<213>  Artificial Sequence(Artificial Sequence)

<220>
<223>  hIL33-99-270


<400>  59
tcaggggtcc agaaatatac tagagcactt catgattcaa gtatcacagg aatttcacct        60
attacagagt atcttgcttc tctaagcaca tacaatgatc aatccattac ttttgctttg       120
gaggatgaaa gttatgagat atatgttgaa gacttgaaaa aagatgaaaa gaaagataag       180
gtgttactga gttactatga gtctcaacac ccctcaaatg aatcaggtga cggtgttgat       240
ggtaagatgt taatggtaac cctgagtcct acaaaagact tctggttgca tgccaacaac       300
aaggaacact ctgtggagct ccataagtgt gaaaaaccac tgccagacca ggccttcttt       360
gtccttcata atatgcactc caactgtgtt tcatttgaat gcaagactga tcctggagtg       420
tttataggtg taaaggataa tcatcttgct ctgattaaag tagactcttc tgagaatttg       480
tgtactgaaa atatcttgtt taagctctct gaaacttag                              519

<210>  60
<211>  489
<212>  DNA
<213>  Artificial Sequence(Artificial Sequence)

<220>
<223>  hIL33-109-270


<400>  60
catgattcaa gtatcacagg aatttcacct attacagagt atcttgcttc tctaagcaca        60
tacaatgatc aatccattac ttttgctttg gaggatgaaa gttatgagat atatgttgaa       120
gacttgaaaa aagatgaaaa gaaagataag gtgttactga gttactatga gtctcaacac       180
ccctcaaatg aatcaggtga cggtgttgat ggtaagatgt taatggtaac cctgagtcct       240
acaaaagact tctggttgca tgccaacaac aaggaacact ctgtggagct ccataagtgt       300
gaaaaaccac tgccagacca ggccttcttt gtccttcata atatgcactc caactgtgtt       360
tcatttgaat gcaagactga tcctggagtg tttataggtg taaaggataa tcatcttgct       420
ctgattaaag tagactcttc tgagaatttg tgtactgaaa atatcttgtt taagctctct       480
gaaacttag                                                               489

<210>  61
<211>  162
<212>  PRT
<213>  Artificial Sequence(Artificial Sequence)

<220>
<223>  mIL15


<400>  61
Met Lys Ile Leu Lys Pro Tyr Met Arg Asn Thr Ser Ile Ser Cys Tyr 
1               5                   10                  15      
Leu Cys Phe Leu Leu Asn Ser His Phe Leu Thr Glu Ala Gly Ile His 
            20                  25                  30          
Val Phe Ile Leu Gly Cys Val Ser Val Gly Leu Pro Lys Thr Glu Ala 
        35                  40                  45              
Asn Trp Ile Asp Val Arg Tyr Asp Leu Glu Lys Ile Glu Ser Leu Ile 
    50                  55                  60                  
Gln Ser Ile His Ile Asp Thr Thr Leu Tyr Thr Asp Ser Asp Phe His 
65                  70                  75                  80  
Pro Ser Cys Lys Val Thr Ala Met Asn Cys Phe Leu Leu Glu Leu Gln 
                85                  90                  95      
Val Ile Leu His Glu Tyr Ser Asn Met Thr Leu Asn Glu Thr Val Arg 
            100                 105                 110         
Asn Val Leu Tyr Leu Ala Asn Ser Thr Leu Ser Ser Asn Lys Asn Val 
        115                 120                 125             
Ala Glu Ser Gly Cys Lys Glu Cys Glu Glu Leu Glu Glu Lys Thr Phe 
    130                 135                 140                 
Thr Glu Phe Leu Gln Ser Phe Ile Arg Ile Val Gln Met Phe Ile Asn 
145                 150                 155                 160 
Thr Ser 
        

<210>  62
<211>  158
<212>  PRT
<213>  Artificial Sequence(Artificial Sequence)

<220>
<223>  mIL17


<400>  62
Met Ser Pro Gly Arg Ala Ser Ser Val Ser Leu Met Leu Leu Leu Leu 
1               5                   10                  15      
Leu Ser Leu Ala Ala Thr Val Lys Ala Ala Ala Ile Ile Pro Gln Ser 
            20                  25                  30          
Ser Ala Cys Pro Asn Thr Glu Ala Lys Asp Phe Leu Gln Asn Val Lys 
        35                  40                  45              
Val Asn Leu Lys Val Phe Asn Ser Leu Gly Ala Lys Val Ser Ser Arg 
    50                  55                  60                  
Arg Pro Ser Asp Tyr Leu Asn Arg Ser Thr Ser Pro Trp Thr Leu His 
65                  70                  75                  80  
Arg Asn Glu Asp Pro Asp Arg Tyr Pro Ser Val Ile Trp Glu Ala Gln 
                85                  90                  95      
Cys Arg His Gln Arg Cys Val Asn Ala Glu Gly Lys Leu Asp His His 
            100                 105                 110         
Met Asn Ser Val Leu Ile Gln Gln Glu Ile Leu Val Leu Lys Arg Glu 
        115                 120                 125             
Pro Glu Ser Cys Pro Phe Thr Phe Arg Val Glu Lys Met Leu Val Gly 
    130                 135                 140                 
Val Gly Cys Thr Cys Val Ala Ser Ile Val Arg Gln Ala Ala 
145                 150                 155             

