                         SEQUENCE LISTING

<110>  Suzhou Neologics Bioscience Co. ,Ltd.
 
<120>  TIM-3-TARGETTING ANTIBODIES AND USES THEREOF

<130>  135A002WO03

<150>  PCT/CN2021/089261
<151>  2021-04-23

<150>  PCT/CN2021/120140
<151>  2021-09-24

<160>  217   

<170>  PatentIn version 3.5

<210>  1
<211>  106
<212>  PRT
<213>  artificial sequence

<220>
<223>  3E6 VL

<400>  1

Asp Ile Ile Met Thr Gln Ser Gln Lys Phe Met Ser Thr Ser Val Gly 
1               5                   10                  15      


Asp Arg Val Ser Val Thr Cys Lys Ala Ser Gln Asn Val Gly Ala Asn 
            20                  25                  30          


Val Ala Trp Tyr Gln Gln Lys Pro Arg Gln Ser Pro Lys Ala Leu Ile 
        35                  40                  45              


Tyr Ser Ala Ser Tyr Arg Tyr Ser Gly Val Pro Asp Arg Phe Thr Gly 
    50                  55                  60                  


Ser Gly Ser Gly Thr Asp Phe Thr Leu Thr Ile Ser Asn Val Gln Ser 
65                  70                  75                  80  


Glu Asp Leu Ala Glu Tyr Phe Cys Gln Gln Tyr Asn Ser Tyr Pro Thr 
                85                  90                  95      


Phe Gly Gly Gly Thr Lys Leu Glu Ile Lys 
            100                 105     


<210>  2
<211>  107
<212>  PRT
<213>  artificial sequence

<220>
<223>  4H2 VL

<400>  2

Asp Ile Gln Met Thr Gln Ser Pro Ser Ser Leu Ser Ala Ser Leu Gly 
1               5                   10                  15      


Gly Lys Val Thr Ile Thr Cys Lys Ala Ser Gln Asp Ile Asn Lys Tyr 
            20                  25                  30          


Ile Ala Trp Tyr Gln His Lys Pro Gly Lys Gly Pro Arg Leu Leu Ile 
        35                  40                  45              


His Tyr Thr Ser Thr Leu Gln Pro Gly Ile Pro Ser Arg Phe Ser Gly 
    50                  55                  60                  


Ser Gly Ser Gly Thr Asp Tyr Ser Phe Ser Ile Ser Asn Leu Glu Pro 
65                  70                  75                  80  


Glu Asp Phe Ala Thr Tyr Tyr Cys Leu Gln Tyr Asp Asn Leu Leu Phe 
                85                  90                  95      


Thr Phe Gly Ser Gly Thr Lys Leu Glu Ile Lys 
            100                 105         


<210>  3
<211>  107
<212>  PRT
<213>  artificial sequence

<220>
<223>  16H1 VL

<400>  3

Asp Ile Val Met Thr Gln Ser His Lys Phe Met Ser Thr Ser Ile Glu 
1               5                   10                  15      


Asp Arg Val Ser Ile Thr Cys Lys Ala Ser Gln Asp Val Ser Ala Ala 
            20                  25                  30          


Val Ala Trp Tyr Gln Gln Lys Pro Gly Gln Thr Pro Lys Leu Leu Ile 
        35                  40                  45              


Tyr Ser Thr Phe Tyr Arg Tyr Ile Gly Val Pro Asp Arg Phe Thr Gly 
    50                  55                  60                  


Ser Gly Ser Gly Thr Asp Phe Thr Phe Thr Ile Thr Ser Val Gln Ala 
65                  70                  75                  80  


Glu Asp Leu Ala Val Tyr Phe Cys Gln Gln His Tyr Ser Val Pro Trp 
                85                  90                  95      


Thr Phe Gly Gly Gly Thr Lys Leu Glu Ile Lys 
            100                 105         


<210>  4
<211>  113
<212>  PRT
<213>  artificial sequence

<220>
<223>  18C6 VL

<400>  4

Asp Val Val Met Thr Gln Thr Pro Leu Ser Leu Pro Val Ser Leu Gly 
1               5                   10                  15      


Asp Gln Ala Ser Ile Ser Cys Arg Ser Ser Gln Ser Leu Val His Ser 
            20                  25                  30          


Asn Gly Asn Thr Tyr Leu His Trp Phe Leu Gln Lys Pro Gly Gln Ser 
        35                  40                  45              


Pro Lys Leu Leu Ile Tyr Lys Val Ser Asn Arg Phe Ser Gly Val Pro 
    50                  55                  60                  


Asp Arg Phe Ser Gly Ser Gly Ser Gly Thr Asp Phe Thr Leu Lys Ile 
65                  70                  75                  80  


Ser Arg Val Glu Ala Glu Asp Leu Gly Val Tyr Phe Cys Cys Gln Ser 
                85                  90                  95      


Thr His Val Pro Pro Leu Thr Phe Gly Ala Gly Thr Lys Leu Glu Leu 
            100                 105                 110         


Lys 
    


<210>  5
<211>  108
<212>  PRT
<213>  artificial sequence

<220>
<223>  19D11 VL

<400>  5

Asp Ile Val Met Thr Gln Ser Gln Lys Phe Met Ser Thr Ser Val Gly 
1               5                   10                  15      


Asp Arg Val Ser Val Thr Cys Lys Ala Ser Gln Asn Val Gly Thr Asn 
            20                  25                  30          


Val Ala Trp Tyr Gln Gln Lys Pro Gly Gln Ser Pro Lys Thr Leu Ile 
        35                  40                  45              


Tyr Ser Ala Ser Tyr Arg Tyr Ser Gly Val Pro Asp Arg Phe Thr Gly 
    50                  55                  60                  


Ser Gly Ser Gly Thr Asp Phe Thr Leu Thr Ile Ser Asn Val Gln Ser 
65                  70                  75                  80  


Glu Asp Leu Ala Glu Tyr Phe Cys Gln Gln Tyr Asn Ser Tyr Pro Leu 
                85                  90                  95      


Val Thr Phe Gly Thr Gly Thr Lys Leu Glu Leu Lys 
            100                 105             


<210>  6
<211>  111
<212>  PRT
<213>  artificial sequence

<220>
<223>  CH 5# VL

<400>  6

Asp Ile Glu Leu Thr Gln Ser Pro Ala Ser Leu Ala Val Ser Leu Gly 
1               5                   10                  15      


Gln Arg Ala Thr Ile Ser Cys Arg Ala Ser Glu Ser Val Glu Tyr Tyr 
            20                  25                  30          


Gly Thr Ser Leu Met Gln Trp Tyr Gln Gln Lys Pro Gly Gln Pro Pro 
        35                  40                  45              


Lys Leu Leu Ile Tyr Ala Ala Ser Asn Val Glu Ser Gly Val Pro Ala 
    50                  55                  60                  


Arg Phe Ser Gly Ser Val Ser Gly Thr Asp Phe Ser Leu Asn Ile His 
65                  70                  75                  80  


Pro Val Glu Glu Asp Asp Ile Ala Met Tyr Phe Cys Gln Gln Ser Arg 
                85                  90                  95      


Lys Val Pro Ile Thr Phe Gly Ser Gly Thr Lys Leu Glu Ile Lys 
            100                 105                 110     


<210>  7
<211>  111
<212>  PRT
<213>  artificial sequence

<220>
<223>  CH 8# VL

<400>  7

Asp Ile Glu Leu Thr Gln Ser Pro Ala Ser Leu Ala Val Ser Leu Gly 
1               5                   10                  15      


Gln Arg Ala Thr Ile Ser Cys Arg Ala Ser Glu Ser Val Glu Tyr Tyr 
            20                  25                  30          


Gly Thr Ser Leu Met Gln Trp Tyr Gln Gln Lys Pro Gly Gln Pro Pro 
        35                  40                  45              


Lys Leu Leu Ile Tyr Ala Ala Ser Asn Val Glu Ser Gly Val Ala Ala 
    50                  55                  60                  


Arg Phe Ser Gly Ser Gly Ser Gly Thr Asp Phe Ser Leu Asn Ile His 
65                  70                  75                  80  


Pro Val Glu Glu Asp Asp Ile Ala Met Tyr Phe Cys Gln Pro Ser Arg 
                85                  90                  95      


Lys Val Pro Tyr Thr Phe Gly Gly Gly Thr Lys Leu Glu Ile Lys 
            100                 105                 110     


<210>  8
<211>  106
<212>  PRT
<213>  artificial sequence

<220>
<223>  CH 9# VL

<400>  8

Asp Ile Glu Leu Thr Gln Ser Pro Ala Ile Leu Ser Ala Ser Pro Gly 
1               5                   10                  15      


Glu Lys Val Thr Met Thr Cys Arg Ala Ser Ser Ser Val Ser Tyr Met 
            20                  25                  30          


His Trp Tyr Gln Gln Lys Pro Gly Ser Ser Pro Lys Pro Trp Ile Tyr 
        35                  40                  45              


Ala Thr Ser Asn Leu Ala Ser Gly Val Pro Ala Arg Phe Ser Gly Ser 
    50                  55                  60                  


Gly Ser Gly Thr Ser Tyr Ser Leu Thr Ile Ser Arg Val Glu Ala Glu 
65                  70                  75                  80  


Asp Ala Ala Thr Tyr Tyr Cys Gln Gln Trp Ser Ser Asn Pro Leu Thr 
                85                  90                  95      


Phe Gly Ala Gly Thr Lys Leu Glu Ile Lys 
            100                 105     


<210>  9
<211>  108
<212>  PRT
<213>  artificial sequence

<220>
<223>  CH 10# VL

<400>  9

Asp Ile Glu Leu Thr Gln Ser Pro Ala Leu Met Ala Ala Ser Pro Gly 
1               5                   10                  15      


Glu Lys Val Thr Ile Thr Cys Ser Ala Ser Ser Ser Val Ser Ser Ser 
            20                  25                  30          


Tyr Leu His Trp Tyr Gln Gln Lys Pro Gly Ser Ser Pro Lys Leu Trp 
        35                  40                  45              


Ile Tyr Ser Thr Ser Asn Leu Ala Ser Gly Val Pro Ala Arg Phe Ser 
    50                  55                  60                  


Gly Ser Gly Ser Gly Thr Ser Tyr Ser Leu Thr Ile Ser Ser Met Glu 
65                  70                  75                  80  


Ala Glu Asp Ala Ala Thr Tyr Tyr Cys Gln Gln Trp Ser Ser Tyr Pro 
                85                  90                  95      


Leu Thr Phe Gly Ala Gly Thr Lys Leu Glu Ile Lys 
            100                 105             


<210>  10
<211>  111
<212>  PRT
<213>  artificial sequence

<220>
<223>  CH 11# VL

<400>  10

Asp Ile Glu Leu Thr Gln Ser Pro Ala Ser Leu Ala Val Ser Leu Gly 
1               5                   10                  15      


Gln Arg Ala Thr Ile Ser Cys Arg Ala Ser Glu Ser Val Glu Tyr Tyr 
            20                  25                  30          


Gly Thr Ser Leu Met Gln Trp Tyr Gln Gln Lys Pro Gly Gln Pro Pro 
        35                  40                  45              


Lys Leu Leu Ile Tyr Ala Ala Ser Asn Val Glu Ser Gly Val Pro Ala 
    50                  55                  60                  


Arg Phe Ser Gly Ser Val Ser Gly Thr Asp Phe Ser Leu Asn Ile His 
65                  70                  75                  80  


Pro Val Glu Glu Asp Asp Ile Ala Val Tyr Phe Cys Gln Gln Ser Arg 
                85                  90                  95      


Lys Val Pro Ile Thr Phe Gly Ser Gly Thr Lys Leu Glu Leu Lys 
            100                 105                 110     


<210>  11
<211>  118
<212>  PRT
<213>  artificial sequence

<220>
<223>  3E6 VH

<400>  11

Asp Val Gln Leu Gln Glu Ala Gly Pro Gly Leu Val Lys Pro Ser Gln 
1               5                   10                  15      


Ser Leu Ser Leu Asn Cys Thr Val Thr Gly Tyr Ser Ile Thr Ser Gly 
            20                  25                  30          


Phe Ala Trp Asn Trp Ile Arg Gln Phe Pro Gly Asn Lys Leu Glu Trp 
        35                  40                  45              


Met Gly Tyr Ile Ser His Ser Gly Ser Thr Ser Tyr Asn Pro Ser Leu 
    50                  55                  60                  


Lys Ser Arg Ile Ser Ile Thr Arg Asp Thr Ser Lys Asn Gln Phe Phe 
65                  70                  75                  80  


Leu Gln Leu Asn Ser Val Thr Thr Glu Asp Thr Ala Thr Tyr Tyr Cys 
                85                  90                  95      


Ala Arg Gly Tyr Arg Ser Pro Trp Phe Ala Tyr Trp Gly Gln Gly Thr 
            100                 105                 110         


Leu Val Thr Val Ser Ala 
        115             


<210>  12
<211>  114
<212>  PRT
<213>  artificial sequence

<220>
<223>  4H2 VH

<400>  12

Glu Val Gln Leu Gln Glu Ser Gly Pro Ser Leu Val Lys Pro Ser Gln 
1               5                   10                  15      


Thr Leu Ser Leu Thr Cys Ser Val Thr Gly Asp Ser Ile Thr Ser Gly 
            20                  25                  30          


Tyr Trp Asn Trp Ile Arg Lys Phe Pro Gly Asn Lys Leu Glu Tyr Met 
        35                  40                  45              


Gly Tyr Ile Asn Tyr Ser Gly Ser Thr Tyr Tyr Asn Pro Ser Leu Lys 
    50                  55                  60                  


Ser Arg Ile Ser Ile Thr Arg Asp Thr Ser Lys Asn Gln Tyr Tyr Leu 
65                  70                  75                  80  


Gln Leu Asn Ser Val Thr Thr Glu Asp Thr Ala Thr Tyr Tyr Cys Ala 
                85                  90                  95      


Thr Gly Asn His Phe Asp Tyr Trp Gly Gln Gly Thr Thr Leu Thr Val 
            100                 105                 110         


Ser Ser 
        


<210>  13
<211>  119
<212>  PRT
<213>  artificial sequence

<220>
<223>  16H1 VH

<400>  13

Gln Val Gln Leu Gln Gln Ser Gly Pro Gln Leu Val Arg Pro Gly Ser 
1               5                   10                  15      


Ser Val Gln Ile Ser Cys Lys Thr Ser Gly Tyr Ser Phe Thr Ser Tyr 
            20                  25                  30          


Leu Met His Trp Val Arg Gln Arg Pro Gly Gln Gly Leu Glu Trp Ile 
        35                  40                  45              


Gly Ser Ile Asp Pro Ser Asp Ser Glu Ile Ser Leu Asn Gln Lys Phe 
    50                  55                  60                  


Met Asp Lys Ala Thr Leu Thr Val Asp Lys Ser Ser Ser Thr Ala Asn 
65                  70                  75                  80  


Met Gln Phe Ser Ser Pro Thr Ser Glu Asp Ser Ala Val Tyr Phe Cys 
                85                  90                  95      


Ala Arg Asp Phe Gly Tyr Val Ala Trp Phe Val Tyr Trp Gly Gln Gly 
            100                 105                 110         


Thr Leu Val Thr Val Ser Ala 
        115                 


<210>  14
<211>  114
<212>  PRT
<213>  artificial sequence

<220>
<223>  18C6 VH

<400>  14

Gln Val Gln Leu Gln Gln Pro Gly Ala Glu Ile Val Met Pro Gly Ala 
1               5                   10                  15      


Ser Val Lys Met Ser Cys Lys Ala Ser Gly Tyr Lys Phe Thr Asp Phe 
            20                  25                  30          


Leu Met His Trp Val Lys Gln Arg Pro Gly Gln Gly Leu Glu Trp Ile 
        35                  40                  45              


Gly Ala Ile Asp Thr Ser Asp Ser Tyr Ala Ser Tyr Asn Gln Lys Phe 
    50                  55                  60                  


Lys Gly Lys Ala Thr Leu Thr Leu Asp Glu Ser Ser Ser Thr Ala Tyr 
65                  70                  75                  80  


Met Gln Leu Ser Ser Leu Thr Ser Glu Asp Ser Ala Val Tyr Tyr Cys 
                85                  90                  95      


Ser Arg Glu Ala Met Asp Tyr Trp Gly Gln Gly Thr Ser Val Thr Val 
            100                 105                 110         


Ser Ser 
        


<210>  15
<211>  118
<212>  PRT
<213>  artificial sequence

<220>
<223>  19D11 VH

<400>  15

Asp Val Gln Leu Gln Glu Ser Gly Pro Asp Leu Val Lys Pro Ser Gln 
1               5                   10                  15      


Ser Leu Ser Leu Thr Cys Thr Val Thr Gly Tyr Ser Ile Thr Ser Gly 
            20                  25                  30          


Tyr Ser Trp His Trp Ile Arg Gln Phe Pro Gly Asn Lys Leu Glu Trp 
        35                  40                  45              


Met Gly Tyr Ile Tyr Phe Ser Gly Ser Thr Asn Tyr Asn Pro Ser Leu 
    50                  55                  60                  


Lys Ser Arg Ile Ser Ile Thr Arg Asp Thr Ser Lys Asn Gln Phe Phe 
65                  70                  75                  80  


Leu Gln Leu Asn Ser Val Thr Thr Glu Asp Thr Ala Thr Tyr Tyr Cys 
                85                  90                  95      


Ala Arg Gly Tyr Arg Ser Ala Trp Phe Ala Tyr Trp Gly Gln Gly Thr 
            100                 105                 110         


Leu Val Thr Val Ser Ala 
        115             


<210>  16
<211>  121
<212>  PRT
<213>  artificial sequence

<220>
<223>  CH 5# VH

<400>  16

Gln Val Gln Leu Gln Gln Ser Gly Pro Asp Leu Val Lys Pro Gly Ala 
1               5                   10                  15      


Ser Val Lys Ile Ser Cys Lys Ala Ser Gly Tyr Ser Phe Thr Gly Tyr 
            20                  25                  30          


Tyr Met His Trp Val Lys Gln Ser His Gly Lys Ser Leu Glu Trp Ile 
        35                  40                  45              


Gly Arg Val Asn Pro Asn Asn Gly Gly Thr Asp Tyr Asp Gln Lys Phe 
    50                  55                  60                  


Lys Gly Lys Ala Ile Leu Ser Val Asp Lys Ser Ser Asn Thr Ala Tyr 
65                  70                  75                  80  


Met Glu Leu Arg Ser Leu Thr Ser Glu Asp Ser Ala Val Tyr Tyr Cys 
                85                  90                  95      


Ala Arg Glu Gly Glu Tyr Phe Asp Tyr Tyr Ala Met Asp Tyr Trp Gly 
            100                 105                 110         


Gln Gly Thr Thr Val Thr Val Ser Ser 
        115                 120     


<210>  17
<211>  121
<212>  PRT
<213>  artificial sequence

<220>
<223>  CH 8# VH

<400>  17

Gln Val Lys Leu Gln Gln Ser Gly Pro Asp Leu Val Lys Pro Gly Ala 
1               5                   10                  15      


Ser Val Lys Ile Ser Cys Lys Ala Ser Gly Tyr Ser Phe Thr Gly Tyr 
            20                  25                  30          


Tyr Met His Trp Val Lys Gln Ser His Gly Lys Ser Leu Glu Trp Ile 
        35                  40                  45              


Gly Arg Val Tyr Pro Asn Asn Gly Gly Thr Ser Tyr Asn Gln Lys Phe 
    50                  55                  60                  


Lys Gly Lys Ala Ile Leu Thr Val Asp Lys Ser Ser Ser Thr Ala Tyr 
65                  70                  75                  80  


Met Glu Leu Arg Ser Leu Thr Ser Glu Asp Ser Ala Val Tyr Tyr Cys 
                85                  90                  95      


Ala Arg Glu Gly Glu Tyr Phe Asp Tyr Phe Ala Met Asp Tyr Trp Gly 
            100                 105                 110         


Gln Gly Thr Thr Val Thr Val Ser Ser 
        115                 120     


<210>  18
<211>  118
<212>  PRT
<213>  artificial sequence

<220>
<223>  CH 9# VH

<400>  18

Gln Val Lys Leu Gln Glu Ser Gly Pro Gly Leu Val Ala Pro Ser Gln 
1               5                   10                  15      


Ser Leu Ser Ile Thr Cys Thr Val Ser Gly Phe Ser Leu Thr Gly Tyr 
            20                  25                  30          


Gly Val His Trp Val Arg Gln Pro Pro Gly Lys Gly Leu Glu Trp Leu 
        35                  40                  45              


Gly Met Ile Trp Gly Asp Gly Ser Thr Asp Tyr Asn Ser Ala Leu Lys 
    50                  55                  60                  


Ser Arg Leu Ser Ile Ser Lys Asp Asn Ser Lys Ser Gln Val Phe Leu 
65                  70                  75                  80  


Lys Met Asn Ser Leu Gln Thr Asp Asp Thr Ala Arg Tyr Tyr Cys Ala 
                85                  90                  95      


Arg Asp Arg Gly Asn His Trp Tyr Phe Asp Val Trp Gly Gln Gly Thr 
            100                 105                 110         


Thr Val Thr Val Ser Ser 
        115             


<210>  19
<211>  118
<212>  PRT
<213>  artificial sequence

<220>
<223>  CH 10# VH

<400>  19

Gln Val Gln Leu Gln Gln Ser Gly Ala Glu Leu Met Lys Pro Gly Ala 
1               5                   10                  15      


Ser Val Lys Ile Ser Cys Lys Ala Ile Gly Tyr Thr Phe Ser Ser Tyr 
            20                  25                  30          


Trp Ile Glu Trp Val Lys Gln Arg Pro Gly His Gly Leu Glu Trp Ile 
        35                  40                  45              


Gly Glu Ile Ser Pro Gly Arg Gly Ser Thr Asn Tyr Asn Glu Lys Phe 
    50                  55                  60                  


Lys Gly Lys Ala Thr Phe Thr Ala Asp Thr Ser Ser Asn Thr Ala Tyr 
65                  70                  75                  80  


Met Gln Leu Ser Ser Leu Thr Ser Glu Asp Ser Ala Val Tyr Tyr Cys 
                85                  90                  95      


Ala Arg Asp Tyr Tyr Gly Ser Ile Phe Asp Val Trp Gly Gln Gly Thr 
            100                 105                 110         


Thr Val Thr Val Ser Ser 
        115             


<210>  20
<211>  121
<212>  PRT
<213>  artificial sequence

<220>
<223>  CH 11# VH

<400>  20

Gln Val Lys Leu Gln Gln Ser Gly Pro Asp Leu Val Lys Pro Gly Ala 
1               5                   10                  15      


Ser Val Lys Ile Ser Cys Lys Ala Ser Gly Tyr Ser Phe Thr Gly Tyr 
            20                  25                  30          


Tyr Met His Trp Val Lys Gln Ser His Gly Lys Ser Leu Glu Trp Ile 
        35                  40                  45              


Gly Arg Val Asn Pro Asn Asn Gly Gly Thr Thr Tyr Lys Gln Lys Phe 
    50                  55                  60                  


Lys Gly Lys Val Ile Leu Thr Val Asp Lys Ser Ser Ser Thr Ala Tyr 
65                  70                  75                  80  


Met Glu Leu Arg Ser Leu Thr Ser Glu Asp Ser Ala Val Tyr Tyr Cys 
                85                  90                  95      


Ala Arg Glu Gly Glu Tyr Phe Asp Tyr Tyr Thr Met Asp Tyr Trp Gly 
            100                 105                 110         


Gln Gly Thr Thr Val Thr Val Ser Ser 
        115                 120     


<210>  21
<211>  106
<212>  PRT
<213>  artificial sequence

<220>
<223>  3E6 VL0

<400>  21

Asp Ile Gln Met Thr Gln Ser Pro Ser Ser Leu Ser Ala Ser Val Gly 
1               5                   10                  15      


Asp Arg Val Thr Ile Thr Cys Lys Ala Ser Gln Asn Val Gly Ala Asn 
            20                  25                  30          


Val Ala Trp Tyr Gln Gln Lys Pro Gly Lys Ala Pro Lys Ser Leu Ile 
        35                  40                  45              


Tyr Ser Ala Ser Tyr Arg Tyr Ser Gly Val Pro Ser Arg Phe Ser Gly 
    50                  55                  60                  


Ser Gly Ser Gly Thr Asp Phe Thr Leu Thr Ile Ser Ser Leu Gln Pro 
65                  70                  75                  80  


Glu Asp Phe Ala Thr Tyr Tyr Cys Gln Gln Tyr Asn Ser Tyr Pro Thr 
                85                  90                  95      


Phe Gly Gly Gly Thr Lys Val Glu Ile Lys 
            100                 105     


<210>  22
<211>  118
<212>  PRT
<213>  artificial sequence

<220>
<223>  3E6 VH0

<400>  22

Gln Val Gln Leu Gln Glu Ser Gly Pro Gly Leu Val Lys Pro Ser Gln 
1               5                   10                  15      


Thr Leu Ser Leu Thr Cys Thr Val Ser Gly Tyr Ser Ile Thr Ser Gly 
            20                  25                  30          


Phe Ala Trp Asn Trp Ile Arg Gln Pro Pro Gly Lys Gly Leu Glu Trp 
        35                  40                  45              


Ile Gly Tyr Ile Ser His Ser Gly Ser Thr Ser Tyr Asn Pro Ser Leu 
    50                  55                  60                  


Lys Ser Arg Val Thr Ile Ser Val Asp Thr Ser Lys Asn Gln Phe Ser 
65                  70                  75                  80  


Leu Lys Leu Ser Ser Val Thr Ala Ala Asp Thr Ala Val Tyr Tyr Cys 
                85                  90                  95      


Ala Arg Gly Tyr Arg Ser Pro Trp Phe Ala Tyr Trp Gly Gln Gly Thr 
            100                 105                 110         


Thr Val Thr Val Ser Ser 
        115             


<210>  23
<211>  118
<212>  PRT
<213>  artificial sequence

<220>
<223>  3E6 VH1

<400>  23

Gln Val Gln Leu Gln Glu Ser Gly Pro Gly Leu Val Lys Pro Ser Gln 
1               5                   10                  15      


Thr Leu Ser Leu Thr Cys Thr Val Ser Gly Tyr Ser Ile Thr Ser Gly 
            20                  25                  30          


Phe Ala Trp Asn Trp Ile Arg Gln Phe Pro Gly Asn Gly Leu Glu Trp 
        35                  40                  45              


Met Gly Tyr Ile Ser His Ser Gly Ser Thr Ser Tyr Asn Pro Ser Leu 
    50                  55                  60                  


Lys Ser Arg Val Thr Ile Ser Val Asp Thr Ser Lys Asn Gln Phe Ser 
65                  70                  75                  80  


Leu Lys Leu Ser Ser Val Thr Ala Ala Asp Thr Ala Val Tyr Tyr Cys 
                85                  90                  95      


Ala Arg Gly Tyr Arg Ser Pro Trp Phe Ala Tyr Trp Gly Gln Gly Thr 
            100                 105                 110         


Thr Val Thr Val Ser Ser 
        115             


<210>  24
<211>  118
<212>  PRT
<213>  artificial sequence

<220>
<223>  3E6 VH2

<400>  24

Gln Val Gln Leu Gln Glu Ser Gly Pro Gly Leu Val Lys Pro Ser Gln 
1               5                   10                  15      


Thr Leu Ser Leu Thr Cys Thr Val Ser Gly Tyr Ser Ile Thr Ser Gly 
            20                  25                  30          


Phe Ala Trp Asn Trp Ile Arg Gln Pro Pro Gly Lys Gly Leu Glu Trp 
        35                  40                  45              


Met Gly Tyr Ile Ser His Ser Gly Ser Thr Ser Tyr Asn Pro Ser Leu 
    50                  55                  60                  


Lys Ser Arg Val Thr Ile Ser Val Asp Thr Ser Lys Asn Gln Phe Ser 
65                  70                  75                  80  


Leu Lys Leu Ser Ser Val Thr Ala Ala Asp Thr Ala Val Tyr Tyr Cys 
                85                  90                  95      


Ala Arg Gly Tyr Arg Ser Pro Trp Phe Ala Tyr Trp Gly Gln Gly Thr 
            100                 105                 110         


Thr Val Thr Val Ser Ser 
        115             


<210>  25
<211>  118
<212>  PRT
<213>  artificial sequence

<220>
<223>  3E6 VH3

<400>  25

Gln Val Gln Leu Gln Glu Ser Gly Pro Gly Leu Val Lys Pro Ser Gln 
1               5                   10                  15      


Thr Leu Ser Leu Thr Cys Thr Val Ser Gly Tyr Ser Ile Thr Ser Gly 
            20                  25                  30          


Phe Ala Trp Asn Trp Ile Arg Gln Pro Pro Gly Asn Gly Leu Glu Trp 
        35                  40                  45              


Ile Gly Tyr Ile Ser His Ser Gly Ser Thr Ser Tyr Asn Pro Ser Leu 
    50                  55                  60                  


Lys Ser Arg Val Thr Ile Ser Val Asp Thr Ser Lys Asn Gln Phe Ser 
65                  70                  75                  80  


Leu Lys Leu Ser Ser Val Thr Ala Ala Asp Thr Ala Val Tyr Tyr Cys 
                85                  90                  95      


Ala Arg Gly Tyr Arg Ser Pro Trp Phe Ala Tyr Trp Gly Gln Gly Thr 
            100                 105                 110         


Thr Val Thr Val Ser Ser 
        115             


<210>  26
<211>  118
<212>  PRT
<213>  artificial sequence

<220>
<223>  3E6 VH4

<400>  26

Gln Val Gln Leu Gln Glu Ser Gly Pro Gly Leu Val Lys Pro Ser Gln 
1               5                   10                  15      


Thr Leu Ser Leu Thr Cys Thr Val Ser Gly Tyr Ser Ile Thr Ser Gly 
            20                  25                  30          


Phe Ala Trp Asn Trp Ile Arg Gln Pro Pro Gly Asn Gly Leu Glu Trp 
        35                  40                  45              


Ile Gly Tyr Ile Ser His Ser Gly Ser Thr Ser Tyr Asn Pro Ser Leu 
    50                  55                  60                  


Lys Ser Arg Ile Thr Ile Ser Val Asp Thr Ser Lys Asn Gln Phe Ser 
65                  70                  75                  80  


Leu Lys Leu Ser Ser Val Thr Ala Ala Asp Thr Ala Val Tyr Tyr Cys 
                85                  90                  95      


Ala Arg Gly Tyr Arg Ser Pro Trp Phe Ala Tyr Trp Gly Gln Gly Thr 
            100                 105                 110         


Thr Val Thr Val Ser Ser 
        115             


<210>  27
<211>  118
<212>  PRT
<213>  artificial sequence

<220>
<223>  3E6 VH5

<400>  27

Gln Val Gln Leu Gln Glu Ser Gly Pro Gly Leu Val Lys Pro Ser Gln 
1               5                   10                  15      


Thr Leu Ser Leu Thr Cys Thr Val Ser Gly Tyr Ser Ile Thr Ser Gly 
            20                  25                  30          


Phe Ala Trp Asn Trp Ile Arg Gln Pro Pro Gly Asn Gly Leu Glu Trp 
        35                  40                  45              


Ile Gly Tyr Ile Ser His Ser Gly Ser Thr Ser Tyr Asn Pro Ser Leu 
    50                  55                  60                  


Lys Ser Arg Ile Thr Ile Ser Arg Asp Thr Ser Lys Asn Gln Phe Ser 
65                  70                  75                  80  


Leu Lys Leu Ser Ser Val Thr Ala Ala Asp Thr Ala Val Tyr Tyr Cys 
                85                  90                  95      


Ala Arg Gly Tyr Arg Ser Pro Trp Phe Ala Tyr Trp Gly Gln Gly Thr 
            100                 105                 110         


Thr Val Thr Val Ser Ser 
        115             


<210>  28
<211>  118
<212>  PRT
<213>  artificial sequence

<220>
<223>  3E6 VH6

<400>  28

Gln Val Gln Leu Gln Glu Ser Gly Pro Gly Leu Val Lys Pro Ser Gln 
1               5                   10                  15      


Thr Leu Ser Leu Thr Cys Thr Val Ser Gly Tyr Ser Ile Thr Ser Gly 
            20                  25                  30          


Phe Ala Trp Asn Trp Ile Arg Gln Pro Pro Gly Lys Gly Leu Glu Trp 
        35                  40                  45              


Met Gly Tyr Ile Ser His Ser Gly Ser Thr Ser Tyr Asn Pro Ser Leu 
    50                  55                  60                  


Lys Ser Arg Ile Thr Ile Ser Val Asp Thr Ser Lys Asn Gln Phe Ser 
65                  70                  75                  80  


Leu Lys Leu Ser Ser Val Thr Ala Ala Asp Thr Ala Val Tyr Tyr Cys 
                85                  90                  95      


Ala Arg Gly Tyr Arg Ser Pro Trp Phe Ala Tyr Trp Gly Gln Gly Thr 
            100                 105                 110         


Thr Val Thr Val Ser Ser 
        115             


<210>  29
<211>  118
<212>  PRT
<213>  artificial sequence

<220>
<223>  3E6 VH7

<400>  29

Gln Val Gln Leu Gln Glu Ser Gly Pro Gly Leu Val Lys Pro Ser Gln 
1               5                   10                  15      


Thr Leu Ser Leu Thr Cys Thr Val Ser Gly Tyr Ser Ile Thr Ser Gly 
            20                  25                  30          


Phe Ala Trp Asn Trp Ile Arg Gln Pro Pro Gly Lys Gly Leu Glu Trp 
        35                  40                  45              


Met Gly Tyr Ile Ser His Ser Gly Ser Thr Ser Tyr Asn Pro Ser Leu 
    50                  55                  60                  


Lys Ser Arg Ile Thr Ile Ser Arg Asp Thr Ser Lys Asn Gln Phe Ser 
65                  70                  75                  80  


Leu Lys Leu Ser Ser Val Thr Ala Ala Asp Thr Ala Val Tyr Tyr Cys 
                85                  90                  95      


Ala Arg Gly Tyr Arg Ser Pro Trp Phe Ala Tyr Trp Gly Gln Gly Thr 
            100                 105                 110         


Thr Val Thr Val Ser Ser 
        115             


<210>  30
<211>  15
<212>  PRT
<213>  artificial sequence

<220>
<223>  Linker

<400>  30

Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser 
1               5                   10                  15  


<210>  31
<211>  13
<212>  PRT
<213>  artificial sequence

<220>
<223>  3E6 VL CDR1

<400>  31

Lys Ala Ser Gln Asn Val Gly Ala Asn Val Ala Trp Tyr 
1               5                   10              


<210>  32
<211>  13
<212>  PRT
<213>  artificial sequence

<220>
<223>  4H2 VL CDR1

<400>  32

Lys Ala Ser Gln Asp Ile Asn Lys Tyr Ile Ala Trp Tyr 
1               5                   10              


<210>  33
<211>  13
<212>  PRT
<213>  artificial sequence

<220>
<223>  16H1 VL CDR1

<400>  33

Lys Ala Ser Gln Asp Val Ser Ala Ala Val Ala Trp Tyr 
1               5                   10              


<210>  34
<211>  18
<212>  PRT
<213>  artificial sequence

<220>
<223>  18C6 VL CDR1

<400>  34

Arg Ser Ser Gln Ser Leu Val His Ser Asn Gly Asn Thr Tyr Leu His 
1               5                   10                  15      


Trp Phe 
        


<210>  35
<211>  13
<212>  PRT
<213>  artificial sequence

<220>
<223>  19D11 VL CDR1

<400>  35

Lys Ala Ser Gln Asn Val Gly Thr Asn Val Ala Trp Tyr 
1               5                   10              


<210>  36
<211>  17
<212>  PRT
<213>  artificial sequence

<220>
<223>  CH 5#, CH 8# , CH 11#  VL CDR1

<400>  36

Arg Ala Ser Glu Ser Val Glu Tyr Tyr Gly Thr Ser Leu Met Gln Trp 
1               5                   10                  15      


Tyr 
    


<210>  37
<211>  12
<212>  PRT
<213>  artificial sequence

<220>
<223>  CH 9# VL CDR1

<400>  37

Arg Ala Ser Ser Ser Val Ser Tyr Met His Trp Tyr 
1               5                   10          


<210>  38
<211>  14
<212>  PRT
<213>  artificial sequence

<220>
<223>  CH 10# VL CDR1

<400>  38

Ser Ala Ser Ser Ser Val Ser Ser Ser Tyr Leu His Trp Tyr 
1               5                   10                  


<210>  39
<211>  11
<212>  PRT
<213>  artificial sequence

<220>
<223>  3E6 VL CDR2

<400>  39

Ala Leu Ile Tyr Ser Ala Ser Tyr Arg Tyr Ser 
1               5                   10      


<210>  40
<211>  11
<212>  PRT
<213>  artificial sequence

<220>
<223>  4H2 VL CDR2

<400>  40

Leu Leu Ile His Tyr Thr Ser Thr Leu Gln Pro 
1               5                   10      


<210>  41
<211>  11
<212>  PRT
<213>  artificial sequence

<220>
<223>  16H1 VL CDR2

<400>  41

Leu Leu Ile Tyr Ser Thr Phe Tyr Arg Tyr Ile 
1               5                   10      


<210>  42
<211>  11
<212>  PRT
<213>  artificial sequence

<220>
<223>  18C6 VL CDR2

<400>  42

Leu Leu Ile Tyr Lys Val Ser Asn Arg Phe Ser 
1               5                   10      


<210>  43
<211>  11
<212>  PRT
<213>  artificial sequence

<220>
<223>  19D11 VL CDR2

<400>  43

Thr Leu Ile Tyr Ser Ala Ser Tyr Arg Tyr Ser 
1               5                   10      


<210>  44
<211>  11
<212>  PRT
<213>  artificial sequence

<220>
<223>  CH 5#, CH 8# , CH 11# VL CDR2

<400>  44

Leu Leu Ile Tyr Ala Ala Ser Asn Val Glu Ser 
1               5                   10      


<210>  45
<211>  11
<212>  PRT
<213>  artificial sequence

<220>
<223>  CH 9# VL CDR2

<400>  45

Pro Trp Ile Tyr Ala Thr Ser Asn Leu Ala Ser 
1               5                   10      


<210>  46
<211>  11
<212>  PRT
<213>  artificial sequence

<220>
<223>  CH 10# VL CDR2

<400>  46

Leu Trp Ile Tyr Ser Thr Ser Asn Leu Ala Ser 
1               5                   10      


<210>  47
<211>  8
<212>  PRT
<213>  artificial sequence

<220>
<223>  3E6 VL CDR3

<400>  47

Gln Gln Tyr Asn Ser Tyr Pro Thr 
1               5               


<210>  48
<211>  9
<212>  PRT
<213>  artificial sequence

<220>
<223>  4H2 VL CDR3

<400>  48

Leu Gln Tyr Asp Asn Leu Leu Phe Thr 
1               5                   


<210>  49
<211>  9
<212>  PRT
<213>  artificial sequence

<220>
<223>  16H1 VL CDR3

<400>  49

Gln Gln His Tyr Ser Val Pro Trp Thr 
1               5                   


<210>  50
<211>  10
<212>  PRT
<213>  artificial sequence

<220>
<223>  18C6 VL CDR3

<400>  50

Cys Gln Ser Thr His Val Pro Pro Leu Thr 
1               5                   10  


<210>  51
<211>  10
<212>  PRT
<213>  artificial sequence

<220>
<223>  19D11 VL CDR3

<400>  51

Gln Gln Tyr Asn Ser Tyr Pro Leu Val Thr 
1               5                   10  


<210>  52
<211>  9
<212>  PRT
<213>  artificial sequence

<220>
<223>  CH 5#, CH 11#  VL CDR3

<400>  52

Gln Gln Ser Arg Lys Val Pro Ile Thr 
1               5                   


<210>  53
<211>  9
<212>  PRT
<213>  artificial sequence

<220>
<223>  CH 8# VL CDR3

<400>  53

Gln Pro Ser Arg Lys Val Pro Tyr Thr 
1               5                   


<210>  54
<211>  9
<212>  PRT
<213>  artificial sequence

<220>
<223>  CH 9# VL CDR3

<400>  54

Gln Gln Trp Ser Ser Asn Pro Leu Thr 
1               5                   


<210>  55
<211>  9
<212>  PRT
<213>  artificial sequence

<220>
<223>  CH 10# VL CDR3

<400>  55

Gln Gln Trp Ser Ser Tyr Pro Leu Thr 
1               5                   


<210>  56
<211>  11
<212>  PRT
<213>  artificial sequence

<220>
<223>  3E6 VH CDR1

<400>  56

Gly Tyr Ser Ile Thr Ser Gly Phe Ala Trp Asn 
1               5                   10      


<210>  57
<211>  10
<212>  PRT
<213>  artificial sequence

<220>
<223>  4H2 VH CDR1

<400>  57

Gly Asp Ser Ile Thr Ser Gly Tyr Trp Asn 
1               5                   10  


<210>  58
<211>  10
<212>  PRT
<213>  artificial sequence

<220>
<223>  16H1 VH CDR1

<400>  58

Gly Tyr Ser Phe Thr Ser Tyr Leu Met His 
1               5                   10  


<210>  59
<211>  10
<212>  PRT
<213>  artificial sequence

<220>
<223>  18C6 VH CDR1

<400>  59

Gly Tyr Lys Phe Thr Asp Phe Leu Met His 
1               5                   10  


<210>  60
<211>  11
<212>  PRT
<213>  artificial sequence

<220>
<223>  19D11 VH CDR1

<400>  60

Gly Tyr Ser Ile Thr Ser Gly Tyr Ser Trp His 
1               5                   10      


<210>  61
<211>  10
<212>  PRT
<213>  artificial sequence

<220>
<223>  CH 5#, CH 8#, CH 11# VH CDR1

<400>  61

Gly Tyr Ser Phe Thr Gly Tyr Tyr Met His 
1               5                   10  


<210>  62
<211>  10
<212>  PRT
<213>  artificial sequence

<220>
<223>  CH 9# VH CDR1

<400>  62

Gly Phe Ser Leu Thr Gly Tyr Gly Val His 
1               5                   10  


<210>  63
<211>  10
<212>  PRT
<213>  artificial sequence

<220>
<223>  CH 10# VH CDR1

<400>  63

Gly Tyr Thr Phe Ser Ser Tyr Trp Ile Glu 
1               5                   10  


<210>  64
<211>  17
<212>  PRT
<213>  artificial sequence

<220>
<223>  3E6 VH CDR2

<400>  64

Gly Tyr Ile Ser His Ser Gly Ser Thr Ser Tyr Asn Pro Ser Leu Lys 
1               5                   10                  15      


Ser 
    


<210>  65
<211>  17
<212>  PRT
<213>  artificial sequence

<220>
<223>  4H2 VH CDR2

<400>  65

Gly Tyr Ile Asn Tyr Ser Gly Ser Thr Tyr Tyr Asn Pro Ser Leu Lys 
1               5                   10                  15      


Ser 
    


<210>  66
<211>  18
<212>  PRT
<213>  artificial sequence

<220>
<223>  16H1 VH CDR2

<400>  66

Gly Ser Ile Asp Pro Ser Asp Ser Glu Ile Ser Leu Asn Gln Lys Phe 
1               5                   10                  15      


Met Asp 
        


<210>  67
<211>  18
<212>  PRT
<213>  artificial sequence

<220>
<223>  18C6 VH CDR2

<400>  67

Gly Ala Ile Asp Thr Ser Asp Ser Tyr Ala Ser Tyr Asn Gln Lys Phe 
1               5                   10                  15      


Lys Gly 
        


<210>  68
<211>  17
<212>  PRT
<213>  artificial sequence

<220>
<223>  19D11 VH CDR2

<400>  68

Gly Tyr Ile Tyr Phe Ser Gly Ser Thr Asn Tyr Asn Pro Ser Leu Lys 
1               5                   10                  15      


Ser 
    


<210>  69
<211>  18
<212>  PRT
<213>  artificial sequence

<220>
<223>  CH 5# VH CDR2

<400>  69

Gly Arg Val Asn Pro Asn Asn Gly Gly Thr Asp Tyr Asp Gln Lys Phe 
1               5                   10                  15      


Lys Gly 
        


<210>  70
<211>  18
<212>  PRT
<213>  artificial sequence

<220>
<223>  CH 8# VH CDR2

<400>  70

Gly Arg Val Tyr Pro Asn Asn Gly Gly Thr Ser Tyr Asn Gln Lys Phe 
1               5                   10                  15      


Lys Gly 
        


<210>  71
<211>  17
<212>  PRT
<213>  artificial sequence

<220>
<223>  CH 9# VH CDR2

<400>  71

Gly Met Ile Trp Gly Asp Gly Ser Thr Asp Tyr Asn Ser Ala Leu Lys 
1               5                   10                  15      


Ser 
    


<210>  72
<211>  18
<212>  PRT
<213>  artificial sequence

<220>
<223>  CH 10# VH CDR2

<400>  72

Gly Glu Ile Ser Pro Gly Arg Gly Ser Thr Asn Tyr Asn Glu Lys Phe 
1               5                   10                  15      


Lys Gly 
        


<210>  73
<211>  18
<212>  PRT
<213>  artificial sequence

<220>
<223>  CH 11# VH CDR2

<400>  73

Gly Arg Val Asn Pro Asn Asn Gly Gly Thr Thr Tyr Lys Gln Lys Phe 
1               5                   10                  15      


Lys Gly 
        


<210>  74
<211>  11
<212>  PRT
<213>  artificial sequence

<220>
<223>  3E6 VH CDR3

<400>  74

Ala Arg Gly Tyr Arg Ser Pro Trp Phe Ala Tyr 
1               5                   10      


<210>  75
<211>  8
<212>  PRT
<213>  artificial sequence

<220>
<223>  4H2 VH CDR3

<400>  75

Ala Thr Gly Asn His Phe Asp Tyr 
1               5               


<210>  76
<211>  12
<212>  PRT
<213>  artificial sequence

<220>
<223>  16H1 VH CDR3

<400>  76

Ala Arg Asp Phe Gly Tyr Val Ala Trp Phe Val Tyr 
1               5                   10          


<210>  77
<211>  7
<212>  PRT
<213>  artificial sequence

<220>
<223>  18C6 VH CDR3

<400>  77

Ser Arg Glu Ala Met Asp Tyr 
1               5           


<210>  78
<211>  11
<212>  PRT
<213>  artificial sequence

<220>
<223>  19D11 VH CDR3

<400>  78

Ala Arg Gly Tyr Arg Ser Ala Trp Phe Ala Tyr 
1               5                   10      


<210>  79
<211>  14
<212>  PRT
<213>  artificial sequence

<220>
<223>  CH 5# VH CDR3

<400>  79

Ala Arg Glu Gly Glu Tyr Phe Asp Tyr Tyr Ala Met Asp Tyr 
1               5                   10                  


<210>  80
<211>  14
<212>  PRT
<213>  artificial sequence

<220>
<223>  CH 8# VH CDR3

<400>  80

Ala Arg Glu Gly Glu Tyr Phe Asp Tyr Phe Ala Met Asp Tyr 
1               5                   10                  


<210>  81
<211>  12
<212>  PRT
<213>  artificial sequence

<220>
<223>  CH 9# VH CDR3

<400>  81

Ala Arg Asp Arg Gly Asn His Trp Tyr Phe Asp Val 
1               5                   10          


<210>  82
<211>  11
<212>  PRT
<213>  artificial sequence

<220>
<223>  CH 10# VH CDR3

<400>  82

Ala Arg Asp Tyr Tyr Gly Ser Ile Phe Asp Val 
1               5                   10      


<210>  83
<211>  14
<212>  PRT
<213>  artificial sequence

<220>
<223>  CH 11# VH CDR3

<400>  83

Ala Arg Glu Gly Glu Tyr Phe Asp Tyr Tyr Thr Met Asp Tyr 
1               5                   10                  


<210>  84
<211>  301
<212>  PRT
<213>  artificial sequence

<220>
<223>  Human Tim-3 Isoform 1

<400>  84

Met Phe Ser His Leu Pro Phe Asp Cys Val Leu Leu Leu Leu Leu Leu 
1               5                   10                  15      


Leu Leu Thr Arg Ser Ser Glu Val Glu Tyr Arg Ala Glu Val Gly Gln 
            20                  25                  30          


Asn Ala Tyr Leu Pro Cys Phe Tyr Thr Pro Ala Ala Pro Gly Asn Leu 
        35                  40                  45              


Val Pro Val Cys Trp Gly Lys Gly Ala Cys Pro Val Phe Glu Cys Gly 
    50                  55                  60                  


Asn Val Val Leu Arg Thr Asp Glu Arg Asp Val Asn Tyr Trp Thr Ser 
65                  70                  75                  80  


Arg Tyr Trp Leu Asn Gly Asp Phe Arg Lys Gly Asp Val Ser Leu Thr 
                85                  90                  95      


Ile Glu Asn Val Thr Leu Ala Asp Ser Gly Ile Tyr Cys Cys Arg Ile 
            100                 105                 110         


Gln Ile Pro Gly Ile Met Asn Asp Glu Lys Phe Asn Leu Lys Leu Val 
        115                 120                 125             


Ile Lys Pro Ala Lys Val Thr Pro Ala Pro Thr Arg Gln Arg Asp Phe 
    130                 135                 140                 


Thr Ala Ala Phe Pro Arg Met Leu Thr Thr Arg Gly His Gly Pro Ala 
145                 150                 155                 160 


Glu Thr Gln Thr Leu Gly Ser Leu Pro Asp Ile Asn Leu Thr Gln Ile 
                165                 170                 175     


Ser Thr Leu Ala Asn Glu Leu Arg Asp Ser Arg Leu Ala Asn Asp Leu 
            180                 185                 190         


Arg Asp Ser Gly Ala Thr Ile Arg Ile Gly Ile Tyr Ile Gly Ala Gly 
        195                 200                 205             


Ile Cys Ala Gly Leu Ala Leu Ala Leu Ile Phe Gly Ala Leu Ile Phe 
    210                 215                 220                 


Lys Trp Tyr Ser His Ser Lys Glu Lys Ile Gln Asn Leu Ser Leu Ile 
225                 230                 235                 240 


Ser Leu Ala Asn Leu Pro Pro Ser Gly Leu Ala Asn Ala Val Ala Glu 
                245                 250                 255     


Gly Ile Arg Ser Glu Glu Asn Ile Tyr Thr Ile Glu Glu Asn Val Tyr 
            260                 265                 270         


Glu Val Glu Glu Pro Asn Glu Tyr Tyr Cys Tyr Val Ser Ser Arg Gln 
        275                 280                 285             


Gln Pro Ser Gln Pro Leu Gly Cys Arg Phe Ala Met Pro 
    290                 295                 300     


<210>  85
<211>  142
<212>  PRT
<213>  artificial sequence

<220>
<223>  Human Tim-3 Isoform 2

<400>  85

Met Phe Ser His Leu Pro Phe Asp Cys Val Leu Leu Leu Leu Leu Leu 
1               5                   10                  15      


Leu Leu Thr Arg Ser Ser Glu Val Glu Tyr Arg Ala Glu Val Gly Gln 
            20                  25                  30          


Asn Ala Tyr Leu Pro Cys Phe Tyr Thr Pro Ala Ala Pro Gly Asn Leu 
        35                  40                  45              


Val Pro Val Cys Trp Gly Lys Gly Ala Cys Pro Val Phe Glu Cys Gly 
    50                  55                  60                  


Asn Val Val Leu Arg Thr Asp Glu Arg Asp Val Asn Tyr Trp Thr Ser 
65                  70                  75                  80  


Arg Tyr Trp Leu Asn Gly Asp Phe Arg Lys Gly Asp Val Ser Leu Thr 
                85                  90                  95      


Ile Glu Asn Val Thr Leu Ala Asp Ser Gly Ile Tyr Cys Cys Arg Ile 
            100                 105                 110         


Gln Ile Pro Gly Ile Met Asn Asp Glu Lys Phe Asn Leu Lys Leu Val 
        115                 120                 125             


Ile Lys Pro Gly Glu Trp Thr Phe Ala Cys His Leu Tyr Glu 
    130                 135                 140         


<210>  86
<211>  11
<212>  PRT
<213>  artificial sequence

<220>
<223>  3E6 VL CDR1

<400>  86

Lys Ala Ser Gln Asn Val Gly Ala Asn Val Ala 
1               5                   10      


<210>  87
<211>  11
<212>  PRT
<213>  artificial sequence

<220>
<223>  4H2 VL CDR1

<400>  87

Lys Ala Ser Gln Asp Ile Asn Lys Tyr Ile Ala 
1               5                   10      


<210>  88
<211>  11
<212>  PRT
<213>  artificial sequence

<220>
<223>  16H1 VL CDR1

<400>  88

Lys Ala Ser Gln Asp Val Ser Ala Ala Val Ala 
1               5                   10      


<210>  89
<211>  16
<212>  PRT
<213>  artificial sequence

<220>
<223>  18C6 VL CDR1

<400>  89

Arg Ser Ser Gln Ser Leu Val His Ser Asn Gly Asn Thr Tyr Leu His 
1               5                   10                  15      


<210>  90
<211>  11
<212>  PRT
<213>  artificial sequence

<220>
<223>  19D11 VL CDR1

<400>  90

Lys Ala Ser Gln Asn Val Gly Thr Asn Val Ala 
1               5                   10      


<210>  91
<211>  15
<212>  PRT
<213>  artificial sequence

<220>
<223>  CH 5#, CH 8#, CH 11#  VL CDR1

<400>  91

Arg Ala Ser Glu Ser Val Glu Tyr Tyr Gly Thr Ser Leu Met Gln 
1               5                   10                  15  


<210>  92
<211>  10
<212>  PRT
<213>  artificial sequence

<220>
<223>  CH 9# VL CDR1

<400>  92

Arg Ala Ser Ser Ser Val Ser Tyr Met His 
1               5                   10  


<210>  93
<211>  12
<212>  PRT
<213>  artificial sequence

<220>
<223>  CH 10# VL CDR1

<400>  93

Ser Ala Ser Ser Ser Val Ser Ser Ser Tyr Leu His 
1               5                   10          


<210>  94
<211>  7
<212>  PRT
<213>  artificial sequence

<220>
<223>  3E6, 19D11 VL CDR2

<400>  94

Ser Ala Ser Tyr Arg Tyr Ser 
1               5           


<210>  95
<211>  7
<212>  PRT
<213>  artificial sequence

<220>
<223>  4H2 VL CDR2

<400>  95

Tyr Thr Ser Thr Leu Gln Pro 
1               5           


<210>  96
<211>  7
<212>  PRT
<213>  artificial sequence

<220>
<223>  16H1 VL CDR2

<400>  96

Ser Thr Phe Tyr Arg Tyr Ile 
1               5           


<210>  97
<211>  7
<212>  PRT
<213>  artificial sequence

<220>
<223>  18C6 VL CDR2

<400>  97

Lys Val Ser Asn Arg Phe Ser 
1               5           


<210>  98
<211>  7
<212>  PRT
<213>  artificial sequence

<220>
<223>  CH 5#, CH 8#, CH 11# VL CDR2

<400>  98

Ala Ala Ser Asn Val Glu Ser 
1               5           


<210>  99
<211>  7
<212>  PRT
<213>  artificial sequence

<220>
<223>  CH 9# VL CDR2

<400>  99

Ala Thr Ser Asn Leu Ala Ser 
1               5           


<210>  100
<211>  7
<212>  PRT
<213>  artificial sequence

<220>
<223>  CH 10#, 39D1 VL CDR2

<400>  100

Ser Thr Ser Asn Leu Ala Ser 
1               5           


<210>  101
<211>  6
<212>  PRT
<213>  artificial sequence

<220>
<223>  3E6 VH CDR1

<400>  101

Ser Gly Phe Ala Trp Asn 
1               5       


<210>  102
<211>  5
<212>  PRT
<213>  artificial sequence

<220>
<223>  4H2 VH CDR1

<400>  102

Ser Gly Tyr Trp Asn 
1               5   


<210>  103
<211>  5
<212>  PRT
<213>  artificial sequence

<220>
<223>  16H1 VH CDR1

<400>  103

Ser Tyr Leu Met His 
1               5   


<210>  104
<211>  5
<212>  PRT
<213>  artificial sequence

<220>
<223>  18C6 VH CDR1

<400>  104

Asp Phe Leu Met His 
1               5   


<210>  105
<211>  6
<212>  PRT
<213>  artificial sequence

<220>
<223>  19D11 VH CDR1

<400>  105

Ser Gly Tyr Ser Trp His 
1               5       


<210>  106
<211>  5
<212>  PRT
<213>  artificial sequence

<220>
<223>  CH 5#, CH 8#, CH 11#, 3F2 VH CDR1

<400>  106

Gly Tyr Tyr Met His 
1               5   


<210>  107
<211>  5
<212>  PRT
<213>  artificial sequence

<220>
<223>  CH 9# VH CDR1

<400>  107

Gly Tyr Gly Val His 
1               5   


<210>  108
<211>  5
<212>  PRT
<213>  artificial sequence

<220>
<223>  CH 10# VH CDR1

<400>  108

Ser Tyr Trp Ile Glu 
1               5   


<210>  109
<211>  16
<212>  PRT
<213>  artificial sequence

<220>
<223>  3E6 VH CDR2

<400>  109

Tyr Ile Ser His Ser Gly Ser Thr Ser Tyr Asn Pro Ser Leu Lys Ser 
1               5                   10                  15      


<210>  110
<211>  16
<212>  PRT
<213>  artificial sequence

<220>
<223>  4H2 VH CDR2

<400>  110

Tyr Ile Asn Tyr Ser Gly Ser Thr Tyr Tyr Asn Pro Ser Leu Lys Ser 
1               5                   10                  15      


<210>  111
<211>  17
<212>  PRT
<213>  artificial sequence

<220>
<223>  16H1 VH CDR2

<400>  111

Ser Ile Asp Pro Ser Asp Ser Glu Ile Ser Leu Asn Gln Lys Phe Met 
1               5                   10                  15      


Asp 
    


<210>  112
<211>  17
<212>  PRT
<213>  artificial sequence

<220>
<223>  18C6 VH CDR2

<400>  112

Ala Ile Asp Thr Ser Asp Ser Tyr Ala Ser Tyr Asn Gln Lys Phe Lys 
1               5                   10                  15      


Gly 
    


<210>  113
<211>  16
<212>  PRT
<213>  artificial sequence

<220>
<223>  19D11 VH CDR2

<400>  113

Tyr Ile Tyr Phe Ser Gly Ser Thr Asn Tyr Asn Pro Ser Leu Lys Ser 
1               5                   10                  15      


<210>  114
<211>  17
<212>  PRT
<213>  artificial sequence

<220>
<223>  CH 5# VH CDR2

<400>  114

Arg Val Asn Pro Asn Asn Gly Gly Thr Asp Tyr Asp Gln Lys Phe Lys 
1               5                   10                  15      


Gly 
    


<210>  115
<211>  17
<212>  PRT
<213>  artificial sequence

<220>
<223>  CH 8# VH CDR2

<400>  115

Arg Val Tyr Pro Asn Asn Gly Gly Thr Ser Tyr Asn Gln Lys Phe Lys 
1               5                   10                  15      


Gly 
    


<210>  116
<211>  16
<212>  PRT
<213>  artificial sequence

<220>
<223>  CH 9# VH CDR2

<400>  116

Met Ile Trp Gly Asp Gly Ser Thr Asp Tyr Asn Ser Ala Leu Lys Ser 
1               5                   10                  15      


<210>  117
<211>  17
<212>  PRT
<213>  artificial sequence

<220>
<223>  CH 10# VH CDR2

<400>  117

Glu Ile Ser Pro Gly Arg Gly Ser Thr Asn Tyr Asn Glu Lys Phe Lys 
1               5                   10                  15      


Gly 
    


<210>  118
<211>  17
<212>  PRT
<213>  artificial sequence

<220>
<223>  CH 11# VH CDR2

<400>  118

Arg Val Asn Pro Asn Asn Gly Gly Thr Thr Tyr Lys Gln Lys Phe Lys 
1               5                   10                  15      


Gly 
    


<210>  119
<211>  9
<212>  PRT
<213>  artificial sequence

<220>
<223>  3E6 VH CDR3

<400>  119

Gly Tyr Arg Ser Pro Trp Phe Ala Tyr 
1               5                   


<210>  120
<211>  6
<212>  PRT
<213>  artificial sequence

<220>
<223>  4H2 VH CDR3

<400>  120

Gly Asn His Phe Asp Tyr 
1               5       


<210>  121
<211>  10
<212>  PRT
<213>  artificial sequence

<220>
<223>  16H1 VH CDR3

<400>  121

Asp Phe Gly Tyr Val Ala Trp Phe Val Tyr 
1               5                   10  


<210>  122
<211>  5
<212>  PRT
<213>  artificial sequence

<220>
<223>  18C6 VH CDR3

<400>  122

Glu Ala Met Asp Tyr 
1               5   


<210>  123
<211>  9
<212>  PRT
<213>  artificial sequence

<220>
<223>  19D11 VH CDR3

<400>  123

Gly Tyr Arg Ser Ala Trp Phe Ala Tyr 
1               5                   


<210>  124
<211>  12
<212>  PRT
<213>  artificial sequence

<220>
<223>  CH 5# VH CDR3

<400>  124

Glu Gly Glu Tyr Phe Asp Tyr Tyr Ala Met Asp Tyr 
1               5                   10          


<210>  125
<211>  12
<212>  PRT
<213>  artificial sequence

<220>
<223>  CH 8# VH CDR3

<400>  125

Glu Gly Glu Tyr Phe Asp Tyr Phe Ala Met Asp Tyr 
1               5                   10          


<210>  126
<211>  10
<212>  PRT
<213>  artificial sequence

<220>
<223>  CH 9# VH CDR3

<400>  126

Asp Arg Gly Asn His Trp Tyr Phe Asp Val 
1               5                   10  


<210>  127
<211>  9
<212>  PRT
<213>  artificial sequence

<220>
<223>  CH 10# VH CDR3

<400>  127

Asp Tyr Tyr Gly Ser Ile Phe Asp Val 
1               5                   


<210>  128
<211>  12
<212>  PRT
<213>  artificial sequence

<220>
<223>  CH 11# VH CDR3

<400>  128

Glu Gly Glu Tyr Phe Asp Tyr Tyr Thr Met Asp Tyr 
1               5                   10          


<210>  129
<211>  17
<212>  PRT
<213>  artificial sequence

<220>
<223>  3F2 VL CDR1

<400>  129

Lys Ser Ser Gln Ser Val Leu Tyr Ser Ser Asn Gln Lys Asn Tyr Leu 
1               5                   10                  15      


Ala 
    


<210>  130
<211>  17
<212>  PRT
<213>  artificial sequence

<220>
<223>  36A2 VL CDR1

<400>  130

Lys Ser Ser Gln Ser Val Leu His Ser Ser Asn Gln Lys Asn Phe Leu 
1               5                   10                  15      


Ala 
    


<210>  131
<211>  12
<212>  PRT
<213>  artificial sequence

<220>
<223>  36B11 VL CDR1

<400>  131

Ser Ala Ser Ser Gly Ile Ser Ser Ser Tyr Leu Tyr 
1               5                   10          


<210>  132
<211>  11
<212>  PRT
<213>  artificial sequence

<220>
<223>  38F8 VL CDR1

<400>  132

Arg Ala Ser Gln Asp Ile Ser Asn Tyr Leu Asn 
1               5                   10      


<210>  133
<211>  17
<212>  PRT
<213>  artificial sequence

<220>
<223>  38A8 VL CDR1

<400>  133

Lys Ser Ser Gln Ser Leu Leu Asn Ser Arg Thr Arg Lys Asn Tyr Leu 
1               5                   10                  15      


Ala 
    


<210>  134
<211>  12
<212>  PRT
<213>  artificial sequence

<220>
<223>  40F11 VL CDR1

<400>  134

Arg Ala Ser Ser Ile Val Ser Ser Ser Tyr Leu His 
1               5                   10          


<210>  135
<211>  11
<212>  PRT
<213>  artificial sequence

<220>
<223>  50H9 VL CDR1

<400>  135

Gln Ala Ser Gln Gly Ser Ser Val Asn Leu Asn 
1               5                   10      


<210>  136
<211>  11
<212>  PRT
<213>  artificial sequence

<220>
<223>  84G10 VL CDR1

<400>  136

Arg Ala Ser Glu Asn Ile Asn Ser Tyr Leu Ala 
1               5                   10      


<210>  137
<211>  10
<212>  PRT
<213>  artificial sequence

<220>
<223>  39D1 VL CDR1

<400>  137

Ser Ala Ser Ser Ser Val Arg Phe Met His 
1               5                   10  


<210>  138
<211>  7
<212>  PRT
<213>  artificial sequence

<220>
<223>  3F2 VL CDR2

<400>  138

Trp Ala Ser Phe Arg Glu Ser 
1               5           


<210>  139
<211>  7
<212>  PRT
<213>  artificial sequence

<220>
<223>  36A2, 38A8 VL CDR2

<400>  139

Trp Ala Ser Thr Arg Glu Ser 
1               5           


<210>  140
<211>  7
<212>  PRT
<213>  artificial sequence

<220>
<223>  36B11 VL CDR2

<400>  140

Gly Thr Ser Asn Leu Ala Ser 
1               5           


<210>  141
<211>  7
<212>  PRT
<213>  artificial sequence

<220>
<223>  38F8 VL CDR2

<400>  141

His Thr Ser Arg Leu Tyr Ser 
1               5           


<210>  142
<211>  7
<212>  PRT
<213>  artificial sequence

<220>
<223>  40F11 VL CDR2

<400>  142

Ser Thr Ser Asn Leu Pro Ser 
1               5           


<210>  143
<211>  7
<212>  PRT
<213>  artificial sequence

<220>
<223>  50H9 VL CDR2

<400>  143

Gly Ser Asn Ile Leu Glu Asp 
1               5           


<210>  144
<211>  7
<212>  PRT
<213>  artificial sequence

<220>
<223>  84G10 VL CDR2

<400>  144

His Ala Lys Thr Leu Ala Ser 
1               5           


<210>  145
<211>  8
<212>  PRT
<213>  artificial sequence

<220>
<223>  3F2 VL CDR3

<400>  145

His Gln Ser Leu Ser Ser Tyr Thr 
1               5               


<210>  146
<211>  8
<212>  PRT
<213>  artificial sequence

<220>
<223>  36A2 VL CDR3

<400>  146

His Gln Tyr Leu Ser Ser Leu Thr 
1               5               


<210>  147
<211>  9
<212>  PRT
<213>  artificial sequence

<220>
<223>  36B11 VL CDR3

<400>  147

His Gln Trp Ser Asn Tyr Pro Tyr Thr 
1               5                   


<210>  148
<211>  9
<212>  PRT
<213>  artificial sequence

<220>
<223>  38F8 VL CDR3

<400>  148

Gln Gln Gly Asn Thr Leu Pro Leu Thr 
1               5                   


<210>  149
<211>  8
<212>  PRT
<213>  artificial sequence

<220>
<223>  38A8 VL CDR3

<400>  149

Lys Gln Ser Tyr Ser Leu Leu Thr 
1               5               


<210>  150
<211>  9
<212>  PRT
<213>  artificial sequence

<220>
<223>  40F11 VL CDR3

<400>  150

Gln Gln Tyr Ser Gly Tyr Pro Tyr Thr 
1               5                   


<210>  151
<211>  9
<212>  PRT
<213>  artificial sequence

<220>
<223>  50H9 VL CDR3

<400>  151

Leu Gln His Ser Tyr Leu Pro Tyr Thr 
1               5                   


<210>  152
<211>  9
<212>  PRT
<213>  artificial sequence

<220>
<223>  84G10 VL CDR3

<400>  152

Gln His His Tyr Gly Thr Pro Leu Thr 
1               5                   


<210>  153
<211>  9
<212>  PRT
<213>  artificial sequence

<220>
<223>  39D1 VL CDR3

<400>  153

Gln Gln Arg Ser Ser Tyr Pro Pro Thr 
1               5                   


<210>  154
<211>  5
<212>  PRT
<213>  artificial sequence

<220>
<223>  36A2 VH CDR1

<400>  154

Ser Phe Glu Met His 
1               5   


<210>  155
<211>  7
<212>  PRT
<213>  artificial sequence

<220>
<223>  36B11 VH CDR1

<400>  155

Thr Ser Gly Met Gly Val Gly 
1               5           


<210>  156
<211>  5
<212>  PRT
<213>  artificial sequence

<220>
<223>  38F8 VH CDR1

<400>  156

Asp Tyr Ser Met Asp 
1               5   


<210>  157
<211>  5
<212>  PRT
<213>  artificial sequence

<220>
<223>  38A8 VH CDR1

<400>  157

Thr Tyr Asn Met His 
1               5   


<210>  158
<211>  5
<212>  PRT
<213>  artificial sequence

<220>
<223>  40F11 VH CDR1

<400>  158

Thr Ala Glu Met Gln 
1               5   


<210>  159
<211>  5
<212>  PRT
<213>  artificial sequence

<220>
<223>  50H9 VH CDR1

<400>  159

Thr Asn Gly Met Ser 
1               5   


<210>  160
<211>  5
<212>  PRT
<213>  artificial sequence

<220>
<223>  84G10 VH CDR1

<400>  160

Ser Tyr Trp Met Asn 
1               5   


<210>  161
<211>  6
<212>  PRT
<213>  artificial sequence

<220>
<223>  39D1 VH CDR1

<400>  161

Ser Ser Tyr Trp Ile Glu 
1               5       


<210>  162
<211>  17
<212>  PRT
<213>  artificial sequence

<220>
<223>  3F2 VH CDR2

<400>  162

Tyr Ile Ser Cys Tyr Asn Gly Ala Thr Asn Tyr Asn Gln Lys Phe Lys 
1               5                   10                  15      


Gly 
    


<210>  163
<211>  17
<212>  PRT
<213>  artificial sequence

<220>
<223>  36A2 VH CDR2

<400>  163

Tyr Ile Ser Gly Gly Ser Thr Thr Ile Tyr Tyr Ala Asp Thr Met Lys 
1               5                   10                  15      


Gly 
    


<210>  164
<211>  16
<212>  PRT
<213>  artificial sequence

<220>
<223>  36B11 VH CDR2

<400>  164

His Ile Trp Trp Asp Asp Val Lys Arg Tyr Asn Pro Ala Leu Lys Ser 
1               5                   10                  15      


<210>  165
<211>  17
<212>  PRT
<213>  artificial sequence

<220>
<223>  38F8 VH CDR2

<400>  165

Asp Ile Asn Pro Asn Tyr Asp Ser Leu Ser Tyr Asn Gln Lys Phe Lys 
1               5                   10                  15      


Gly 
    


<210>  166
<211>  17
<212>  PRT
<213>  artificial sequence

<220>
<223>  38A8 VH CDR2

<400>  166

Gly Ile Tyr Pro Gly Asn Gly Asp Thr Ser Tyr Asn Gln Lys Phe Lys 
1               5                   10                  15      


Gly 
    


<210>  167
<211>  17
<212>  PRT
<213>  artificial sequence

<220>
<223>  40F11 VH CDR2

<400>  167

Trp Ile Asn Thr Arg Ser Gly Val Pro Lys Tyr Ala Glu Asp Phe Lys 
1               5                   10                  15      


Gly 
    


<210>  168
<211>  17
<212>  PRT
<213>  artificial sequence

<220>
<223>  50H9 VH CDR2

<400>  168

Thr Ile Ser Ser Gly Gly Ser Asn Thr Tyr Tyr Pro Asp Ser Val Lys 
1               5                   10                  15      


Gly 
    


<210>  169
<211>  17
<212>  PRT
<213>  artificial sequence

<220>
<223>  84G10 VH CDR2

<400>  169

Gln Ile Tyr Pro Gly Glu Gly Asp Thr Asn Tyr Asn Gly Lys Phe Lys 
1               5                   10                  15      


Gly 
    


<210>  170
<211>  17
<212>  PRT
<213>  artificial sequence

<220>
<223>  39D1 VH CDR2

<400>  170

Glu Ile Leu Pro Gly Ser Gly Ser Ile Asn Tyr Asn Glu Lys Phe Lys 
1               5                   10                  15      


Gly 
    


<210>  171
<211>  9
<212>  PRT
<213>  artificial sequence

<220>
<223>  3F2 VH CDR3

<400>  171

Asp Tyr Tyr Leu Ser Val Met Asp Tyr 
1               5                   


<210>  172
<211>  8
<212>  PRT
<213>  artificial sequence

<220>
<223>  36A2 VH CDR3

<400>  172

Ser Tyr Tyr Gly Leu Leu Asp Tyr 
1               5               


<210>  173
<211>  10
<212>  PRT
<213>  artificial sequence

<220>
<223>  36B11 VH CDR3

<400>  173

Thr Phe Ile Thr Thr Thr Thr Met Asp Tyr 
1               5                   10  


<210>  174
<211>  10
<212>  PRT
<213>  artificial sequence

<220>
<223>  38F8 VH CDR3

<400>  174

Arg Gly Tyr Gly Lys Asp Tyr Phe Asp Phe 
1               5                   10  


<210>  175
<211>  10
<212>  PRT
<213>  artificial sequence

<220>
<223>  38A8 VH CDR3

<400>  175

Ser Tyr Tyr Thr Phe Asp Ala Met Asp Cys 
1               5                   10  


<210>  176
<211>  7
<212>  PRT
<213>  artificial sequence

<220>
<223>  40F11 VH CDR3

<400>  176

Gly Thr Tyr Ala Met Asp Tyr 
1               5           


<210>  177
<211>  9
<212>  PRT
<213>  artificial sequence

<220>
<223>  50H9 VH CDR3

<400>  177

Arg Ser Glu Leu Gly Pro Phe Ala Tyr 
1               5                   


<210>  178
<211>  13
<212>  PRT
<213>  artificial sequence

<220>
<223>  84G10 VH CDR3

<400>  178

Gly His Phe Tyr Gly Ser Ser Tyr Asp Trp Phe Ala Tyr 
1               5                   10              


<210>  179
<211>  8
<212>  PRT
<213>  artificial sequence

<220>
<223>  39D1 VH CDR3

<400>  179

Ser Tyr Tyr Tyr Val Met Asp Tyr 
1               5               


<210>  180
<211>  112
<212>  PRT
<213>  artificial sequence

<220>
<223>  3F2 VL

<400>  180

Asn Ile Met Met Thr Gln Ser Pro Ser Ser Leu Ala Val Ser Ala Gly 
1               5                   10                  15      


Glu Lys Val Thr Met Ser Cys Lys Ser Ser Gln Ser Val Leu Tyr Ser 
            20                  25                  30          


Ser Asn Gln Lys Asn Tyr Leu Ala Trp Tyr Gln Gln Lys Pro Gly Gln 
        35                  40                  45              


Ser Pro Lys Leu Leu Ile Tyr Trp Ala Ser Phe Arg Glu Ser Gly Val 
    50                  55                  60                  


Pro Asp Arg Phe Thr Gly Ser Gly Ser Gly Thr Asp Phe Thr Leu Thr 
65                  70                  75                  80  


Ile Ser Ser Val Gln Ala Glu Asp Leu Ala Val Tyr Tyr Cys His Gln 
                85                  90                  95      


Ser Leu Ser Ser Tyr Thr Phe Gly Gly Gly Thr Lys Leu Glu Ile Lys 
            100                 105                 110         


<210>  181
<211>  112
<212>  PRT
<213>  artificial sequence

<220>
<223>  36A2 VL

<400>  181

Asn Ile Met Met Thr Gln Ser Pro Ser Ser Leu Ser Val Ser Thr Gly 
1               5                   10                  15      


Glu Lys Val Thr Met Ser Cys Lys Ser Ser Gln Ser Val Leu His Ser 
            20                  25                  30          


Ser Asn Gln Lys Asn Phe Leu Ala Trp Phe Gln Gln Lys Pro Gly Gln 
        35                  40                  45              


Ser Pro Lys Leu Leu Ile Tyr Trp Ala Ser Thr Arg Glu Ser Gly Val 
    50                  55                  60                  


Pro Asp Arg Phe Thr Gly Ser Gly Ser Gly Thr Asp Phe Thr Leu Thr 
65                  70                  75                  80  


Ile Asn Asn Val Gln Pro Glu Asp Leu Ala Val Tyr Tyr Cys His Gln 
                85                  90                  95      


Tyr Leu Ser Ser Leu Thr Phe Gly Ala Gly Thr Lys Leu Glu Leu Lys 
            100                 105                 110         


<210>  182
<211>  108
<212>  PRT
<213>  artificial sequence

<220>
<223>  36B11 VL

<400>  182

Gln Ile Val Leu Thr Gln Ser Pro Thr Ile Met Ser Ala Ser Pro Gly 
1               5                   10                  15      


Glu Lys Val Thr Leu Thr Cys Ser Ala Ser Ser Gly Ile Ser Ser Ser 
            20                  25                  30          


Tyr Leu Tyr Trp Tyr Gln Gln Lys Pro Gly Ser Ser Pro Lys Leu Trp 
        35                  40                  45              


Ile Tyr Gly Thr Ser Asn Leu Ala Ser Gly Val Pro Ala Arg Phe Ser 
    50                  55                  60                  


Gly Ser Gly Ser Gly Thr Ser Tyr Ser Leu Thr Ile Ser Ser Leu Glu 
65                  70                  75                  80  


Ala Glu Asp Ala Ala Ser Tyr Phe Cys His Gln Trp Ser Asn Tyr Pro 
                85                  90                  95      


Tyr Thr Phe Gly Gly Gly Thr Lys Leu Glu Ile Lys 
            100                 105             


<210>  183
<211>  107
<212>  PRT
<213>  artificial sequence

<220>
<223>  38F8 VL

<400>  183

Thr Trp Gly Met Thr Gln Thr Thr Ser Ser Leu Ser Ala Ser Leu Gly 
1               5                   10                  15      


Asp Arg Val Thr Ile Ser Cys Arg Ala Ser Gln Asp Ile Ser Asn Tyr 
            20                  25                  30          


Leu Asn Trp Tyr Gln Gln Lys Pro Asp Gly Thr Val Lys Leu Leu Ile 
        35                  40                  45              


Tyr His Thr Ser Arg Leu Tyr Ser Gly Val Pro Ser Arg Phe Thr Gly 
    50                  55                  60                  


Ser Gly Ser Gly Thr Asp Tyr Ser Leu Thr Ile Ser Asn Leu Glu Gln 
65                  70                  75                  80  


Glu Asp Ile Ala Thr Tyr Phe Cys Gln Gln Gly Asn Thr Leu Pro Leu 
                85                  90                  95      


Thr Phe Gly Ala Gly Thr Lys Leu Glu Leu Lys 
            100                 105         


<210>  184
<211>  112
<212>  PRT
<213>  artificial sequence

<220>
<223>  38A8 VL

<400>  184

Asp Ile Val Met Ser Gln Ser Pro Ser Ser Leu Ala Val Ser Ala Gly 
1               5                   10                  15      


Glu Lys Val Thr Met Ser Cys Lys Ser Ser Gln Ser Leu Leu Asn Ser 
            20                  25                  30          


Arg Thr Arg Lys Asn Tyr Leu Ala Trp Tyr Gln Gln Lys Pro Gly Arg 
        35                  40                  45              


Ser Pro Lys Leu Leu Ile Tyr Trp Ala Ser Thr Arg Glu Ser Gly Val 
    50                  55                  60                  


Pro Asp Arg Phe Thr Gly Gly Gly Ser Gly Thr Asp Phe Thr Leu Thr 
65                  70                  75                  80  


Ile Ser Ser Val Gln Ala Glu Asp Leu Ala Val Tyr Tyr Cys Lys Gln 
                85                  90                  95      


Ser Tyr Ser Leu Leu Thr Phe Gly Ala Gly Thr Lys Leu Glu Leu Lys 
            100                 105                 110         


<210>  185
<211>  108
<212>  PRT
<213>  artificial sequence

<220>
<223>  40F11 VL

<400>  185

Glu Asn Val Leu Thr Gln Ser Pro Ala Ile Met Ser Ala Ser Pro Gly 
1               5                   10                  15      


Glu Lys Val Thr Met Thr Cys Arg Ala Ser Ser Ile Val Ser Ser Ser 
            20                  25                  30          


Tyr Leu His Trp Tyr Gln Gln Lys Ser Gly Ala Ser Pro Lys Leu Trp 
        35                  40                  45              


Ile Tyr Ser Thr Ser Asn Leu Pro Ser Gly Val Pro Ala Arg Phe Ser 
    50                  55                  60                  


Gly Ser Gly Ser Gly Thr Phe Tyr Ser Leu Thr Val Ser Ser Val Glu 
65                  70                  75                  80  


Ser Glu Asp Ala Ala Thr Tyr Tyr Cys Gln Gln Tyr Ser Gly Tyr Pro 
                85                  90                  95      


Tyr Thr Phe Gly Gly Gly Thr Lys Leu Glu Ile Lys 
            100                 105             


<210>  186
<211>  107
<212>  PRT
<213>  artificial sequence

<220>
<223>  50H9 VL

<400>  186

Asp Val Gln Met Ile Gln Ser Pro Ser Ser Leu Ser Ala Ser Leu Gly 
1               5                   10                  15      


Asp Ile Val Thr Met Thr Cys Gln Ala Ser Gln Gly Ser Ser Val Asn 
            20                  25                  30          


Leu Asn Trp Phe Gln Gln Lys Pro Gly Lys Ser Pro Lys Leu Leu Ile 
        35                  40                  45              


His Gly Ser Asn Ile Leu Glu Asp Gly Val Pro Ser Arg Phe Ser Gly 
    50                  55                  60                  


Ser Arg Tyr Gly Thr Asp Phe Thr Leu Thr Ile Ser Ser Leu Glu Asn 
65                  70                  75                  80  


Glu Asp Met Ala Thr Tyr Phe Cys Leu Gln His Ser Tyr Leu Pro Tyr 
                85                  90                  95      


Thr Phe Gly Gly Gly Thr Lys Leu Glu Ile Lys 
            100                 105         


<210>  187
<211>  107
<212>  PRT
<213>  artificial sequence

<220>
<223>  84G10 VL

<400>  187

Asp Ile Gln Met Thr Gln Ser Pro Ala Ser Leu Ser Ala Ser Val Gly 
1               5                   10                  15      


Glu Thr Val Thr Ile Thr Cys Arg Ala Ser Glu Asn Ile Asn Ser Tyr 
            20                  25                  30          


Leu Ala Trp Tyr Gln Gln Lys Gln Gly Lys Ser Pro Gln Leu Leu Val 
        35                  40                  45              


Tyr His Ala Lys Thr Leu Ala Ser Gly Val Pro Ser Arg Phe Ser Gly 
    50                  55                  60                  


Ser Gly Ser Gly Thr Gln Phe Ser Leu Lys Ile Asn Ser Leu Gln Pro 
65                  70                  75                  80  


Glu Asp Phe Gly Ser Tyr Tyr Cys Gln His His Tyr Gly Thr Pro Leu 
                85                  90                  95      


Thr Phe Gly Ala Gly Ala Arg Leu Glu Leu Lys 
            100                 105         


<210>  188
<211>  106
<212>  PRT
<213>  artificial sequence

<220>
<223>  39D1 VL

<400>  188

Gln Ile Val Leu Thr Gln Ser Pro Ala Ile Met Ser Ala Ser Pro Gly 
1               5                   10                  15      


Glu Met Leu Thr Ile Thr Cys Ser Ala Ser Ser Ser Val Arg Phe Met 
            20                  25                  30          


His Trp Phe Gln Gln Lys Pro Gly Thr Ser Pro Lys Leu Trp Ile Tyr 
        35                  40                  45              


Ser Thr Ser Asn Leu Ala Ser Gly Val Pro Ala Arg Phe Ser Gly Ser 
    50                  55                  60                  


Gly Ser Gly Thr Ser Tyr Ser Leu Thr Val Ser Arg Met Glu Ala Glu 
65                  70                  75                  80  


Asp Ala Ala Thr Tyr Tyr Cys Gln Gln Arg Ser Ser Tyr Pro Pro Thr 
                85                  90                  95      


Phe Gly Gly Gly Thr Lys Leu Glu Ile Lys 
            100                 105     


<210>  189
<211>  118
<212>  PRT
<213>  artificial sequence

<220>
<223>  3F2 VH

<400>  189

Glu Val Gln Leu Gln Gln Ser Gly Pro Glu Leu Val Lys Thr Gly Ser 
1               5                   10                  15      


Ser Val Lys Ile Ser Cys Lys Ala Ser Gly Tyr Ser Phe Thr Gly Tyr 
            20                  25                  30          


Tyr Met His Trp Val Arg Gln Ser Pro Gly Lys Ser Leu Glu Trp Ile 
        35                  40                  45              


Gly Tyr Ile Ser Cys Tyr Asn Gly Ala Thr Asn Tyr Asn Gln Lys Phe 
    50                  55                  60                  


Lys Gly Lys Ala Thr Phe Thr Val Asp Thr Tyr Ser Ser Thr Ala Tyr 
65                  70                  75                  80  


Met Gln Phe Asp Ser Leu Ala Ser Glu Asp Ser Ala Val Tyr Tyr Cys 
                85                  90                  95      


Val Arg Asp Tyr Tyr Leu Ser Val Met Asp Tyr Trp Gly Gln Gly Thr 
            100                 105                 110         


Ser Val Thr Val Ser Ser 
        115             


<210>  190
<211>  117
<212>  PRT
<213>  artificial sequence

<220>
<223>  36A2 VH

<400>  190

Asp Val Gln Leu Val Glu Ser Gly Gly Gly Leu Val Gln Pro Gly Gly 
1               5                   10                  15      


Ser Arg Lys Leu Ser Cys Ala Ala Ser Gly Phe Thr Phe Ser Ser Phe 
            20                  25                  30          


Glu Met His Trp Val Arg Gln Ala Pro Glu Thr Gly Leu Glu Trp Val 
        35                  40                  45              


Ala Tyr Ile Ser Gly Gly Ser Thr Thr Ile Tyr Tyr Ala Asp Thr Met 
    50                  55                  60                  


Lys Gly Arg Phe Thr Ile Ser Arg Asp Asn Pro Glu Asn Thr Leu Phe 
65                  70                  75                  80  


Leu Gln Met Thr Ser Leu Arg Ser Glu Asp Thr Ala Ile Tyr Tyr Cys 
                85                  90                  95      


Val Arg Ser Tyr Tyr Gly Leu Leu Asp Tyr Trp Gly Gln Gly Thr Thr 
            100                 105                 110         


Leu Thr Val Ser Ser 
        115         


<210>  191
<211>  120
<212>  PRT
<213>  artificial sequence

<220>
<223>  36B11 VH

<400>  191

Gln Val Thr Leu Lys Glu Ser Gly Pro Gly Ile Leu Gln Pro Ser Gln 
1               5                   10                  15      


Thr Leu Ser Leu Thr Cys Ser Phe Ser Gly Phe Ser Leu Ser Thr Ser 
            20                  25                  30          


Gly Met Gly Val Gly Trp Ile Arg Gln Pro Ser Gly Lys Gly Leu Glu 
        35                  40                  45              


Trp Leu Ala His Ile Trp Trp Asp Asp Val Lys Arg Tyr Asn Pro Ala 
    50                  55                  60                  


Leu Lys Ser Arg Leu Thr Ile Ser Lys Asp Thr Ser Ser Ser Gln Val 
65                  70                  75                  80  


Phe Leu Lys Ile Ala Ser Val Asp Thr Ala Asp Thr Ala Thr Tyr Tyr 
                85                  90                  95      


Cys Val Arg Thr Phe Ile Thr Thr Thr Thr Met Asp Tyr Trp Gly Gln 
            100                 105                 110         


Gly Thr Ser Val Thr Val Ser Ser 
        115                 120 


<210>  192
<211>  119
<212>  PRT
<213>  artificial sequence

<220>
<223>  38F8 VH

<400>  192

Glu Val Gln Leu Gln Gln Leu Gly Ala Glu Leu Val Lys Pro Gly Ala 
1               5                   10                  15      


Ser Val Lys Ile Ser Cys Lys Ala Ser Gly Tyr Ile Phe Thr Asp Tyr 
            20                  25                  30          


Ser Met Asp Trp Val Lys Gln Ser His Gly Glu Ser Leu Glu Trp Ile 
        35                  40                  45              


Gly Asp Ile Asn Pro Asn Tyr Asp Ser Leu Ser Tyr Asn Gln Lys Phe 
    50                  55                  60                  


Lys Gly Lys Ala Thr Leu Thr Val Asp Lys Ser Ser Ser Thr Ala Tyr 
65                  70                  75                  80  


Met Glu Leu Arg Ser Leu Thr Ser Glu Asp Thr Ala Val Tyr Tyr Cys 
                85                  90                  95      


Ala Arg Arg Gly Tyr Gly Lys Asp Tyr Phe Asp Phe Trp Gly Gln Gly 
            100                 105                 110         


Thr Ser Leu Thr Val Ser Ser 
        115                 


<210>  193
<211>  119
<212>  PRT
<213>  artificial sequence

<220>
<223>  38A8 VH

<400>  193

Gln Val Gln Leu Gln Gln Pro Gly Ala Glu Leu Val Lys Pro Gly Ala 
1               5                   10                  15      


Ser Val Lys Met Ser Cys Lys Ala Ser Gly Tyr Thr Phe Thr Thr Tyr 
            20                  25                  30          


Asn Met His Trp Val Lys Gln Thr Pro Gly Gln Gly Leu Glu Trp Ile 
        35                  40                  45              


Gly Gly Ile Tyr Pro Gly Asn Gly Asp Thr Ser Tyr Asn Gln Lys Phe 
    50                  55                  60                  


Lys Gly Lys Ala Thr Leu Thr Ala Asp Lys Ser Ser Ser Thr Ala Tyr 
65                  70                  75                  80  


Met Gln Leu Ser Ser Leu Thr Ser Glu Asp Ser Ala Val Tyr Tyr Cys 
                85                  90                  95      


Ala Arg Ser Tyr Tyr Thr Phe Asp Ala Met Asp Cys Trp Gly Gln Gly 
            100                 105                 110         


Thr Ser Val Thr Val Ser Ser 
        115                 


<210>  194
<211>  116
<212>  PRT
<213>  artificial sequence

<220>
<223>  40F11 VH

<400>  194

Gln Ile Gln Leu Val Gln Ser Gly Pro Glu Leu Lys Lys Pro Gly Glu 
1               5                   10                  15      


Thr Val Arg Ile Ser Cys Lys Ala Ser Gly Tyr Thr Phe Arg Thr Ala 
            20                  25                  30          


Glu Met Gln Trp Val Gln Lys Met Pro Gly Arg Gly Leu Lys Trp Ile 
        35                  40                  45              


Gly Trp Ile Asn Thr Arg Ser Gly Val Pro Lys Tyr Ala Glu Asp Phe 
    50                  55                  60                  


Lys Gly Arg Phe Ala Leu Ser Leu Glu Thr Ser Ala Thr Thr Ala Tyr 
65                  70                  75                  80  


Leu Gln Ile Ser Asn Leu Lys Asn Glu Asp Thr Ala Thr Tyr Phe Cys 
                85                  90                  95      


Thr Arg Gly Thr Tyr Ala Met Asp Tyr Trp Gly Gln Gly Thr Ser Val 
            100                 105                 110         


Thr Val Ser Ser 
        115     


<210>  195
<211>  118
<212>  PRT
<213>  artificial sequence

<220>
<223>  50H9 VH

<400>  195

Glu Val Gln Leu Val Glu Ser Gly Gly Asp Leu Val Lys Pro Gly Gly 
1               5                   10                  15      


Ser Leu Lys Leu Ser Cys Ala Ala Ser Gly Phe Thr Phe Ser Thr Asn 
            20                  25                  30          


Gly Met Ser Trp Val Arg Gln Ile Pro Asp Lys Arg Leu Glu Trp Val 
        35                  40                  45              


Ala Thr Ile Ser Ser Gly Gly Ser Asn Thr Tyr Tyr Pro Asp Ser Val 
    50                  55                  60                  


Lys Gly Arg Phe Thr Ile Ser Arg Asp Asn Ala Lys Asn Thr Leu Tyr 
65                  70                  75                  80  


Leu Gln Met Ser Ser Leu Lys Ser Glu Asp Thr Ala Met Tyr Tyr Cys 
                85                  90                  95      


Ala Arg Arg Ser Glu Leu Gly Pro Phe Ala Tyr Trp Gly Gln Gly Thr 
            100                 105                 110         


Leu Val Thr Val Ser Ala 
        115             


<210>  196
<211>  122
<212>  PRT
<213>  artificial sequence

<220>
<223>  84G10 VH

<400>  196

Gln Val Gln Leu Gln Gln Ser Gly Gly Glu Leu Val Arg Pro Gly Ser 
1               5                   10                  15      


Ser Val Lys Ile Ser Cys Lys Ala Ser Gly Tyr Ala Phe Ser Ser Tyr 
            20                  25                  30          


Trp Met Asn Trp Val Lys Gln Arg Pro Gly Gln Gly Leu Glu Trp Ile 
        35                  40                  45              


Gly Gln Ile Tyr Pro Gly Glu Gly Asp Thr Asn Tyr Asn Gly Lys Phe 
    50                  55                  60                  


Lys Gly Lys Ala Thr Leu Thr Ala Asp Lys Ser Ser Ser Thr Ala Tyr 
65                  70                  75                  80  


Met Gln Leu Ser Ser Leu Thr Ser Glu Asp Ser Ala Val Tyr Phe Cys 
                85                  90                  95      


Ala Arg Gly His Phe Tyr Gly Ser Ser Tyr Asp Trp Phe Ala Tyr Trp 
            100                 105                 110         


Gly Gln Gly Thr Leu Val Thr Val Ser Ala 
        115                 120         


<210>  197
<211>  118
<212>  PRT
<213>  artificial sequence

<220>
<223>  39D1 VH

<400>  197

Gln Val Gln Leu Gln Gln Ser Gly Ala Glu Leu Met Lys Pro Gly Ala 
1               5                   10                  15      


Ser Val Lys Ile Ser Cys Lys Ala Thr Gly Tyr Thr Phe Ser Ser Ser 
            20                  25                  30          


Tyr Trp Ile Glu Trp Val Lys Gln Arg Pro Gly His Gly Leu Glu Trp 
        35                  40                  45              


Ile Gly Glu Ile Leu Pro Gly Ser Gly Ser Ile Asn Tyr Asn Glu Lys 
    50                  55                  60                  


Phe Lys Gly Lys Ala Thr Phe Thr Ala Asp Thr Ser Ser Asn Thr Val 
65                  70                  75                  80  


Tyr Met Gln Leu Ser Ser Leu Thr Ser Asp Asp Ser Ala Val Tyr Tyr 
                85                  90                  95      


Cys Ala Arg Ser Tyr Tyr Tyr Val Met Asp Tyr Trp Gly Gln Gly Thr 
            100                 105                 110         


Ser Val Thr Val Ser Ser 
        115             


<210>  198
<211>  8
<212>  PRT
<213>  artificial sequence

<220>
<223>  3E6L-v1 VL CDR3

<400>  198

Ser Gln Val Asn Ser Tyr Asn Thr 
1               5               


<210>  199
<211>  8
<212>  PRT
<213>  artificial sequence

<220>
<223>  3E6L-v2 VL CDR3

<400>  199

Glu Gln Val Asn Ser Tyr Pro Thr 
1               5               


<210>  200
<211>  8
<212>  PRT
<213>  artificial sequence

<220>
<223>  3E6L-v3 VL CDR3

<400>  200

Ser Gln Tyr Asn Pro Tyr Asn Thr 
1               5               


<210>  201
<211>  8
<212>  PRT
<213>  artificial sequence

<220>
<223>  3E6L-v4 VL CDR3

<400>  201

Ser Gln Val Asn Pro Tyr Asn Thr 
1               5               


<210>  202
<211>  8
<212>  PRT
<213>  artificial sequence

<220>
<223>  3E6L-v5 VL CDR3

<400>  202

Glu Gln Val Asn Pro Tyr Pro Thr 
1               5               


<210>  203
<211>  8
<212>  PRT
<213>  artificial sequence

<220>
<223>  3E6L-v6 VL CDR3

<400>  203

Gln Gln Val Asn Pro Tyr Pro Thr 
1               5               


<210>  204
<211>  8
<212>  PRT
<213>  artificial sequence

<220>
<223>  3E6L-v7 VL CDR3

<400>  204

Glu Gln Tyr Asn Pro Tyr Pro Thr 
1               5               


<210>  205
<211>  8
<212>  PRT
<213>  artificial sequence

<220>
<223>  3E6L-v8 VL CDR3

<400>  205

Ser Gln Val Asn Ser Tyr Pro Thr 
1               5               


<210>  206
<211>  8
<212>  PRT
<213>  artificial sequence

<220>
<223>  3E6L-v9 VL CDR3

<400>  206

Glu Gln Val Gln Ser Tyr Pro Thr 
1               5               


<210>  207
<211>  106
<212>  PRT
<213>  artificial sequence

<220>
<223>  3E6 VL0-v1

<400>  207

Asp Ile Gln Met Thr Gln Ser Pro Ser Ser Leu Ser Ala Ser Val Gly 
1               5                   10                  15      


Asp Arg Val Thr Ile Thr Cys Lys Ala Ser Gln Asn Val Gly Ala Asn 
            20                  25                  30          


Val Ala Trp Tyr Gln Gln Lys Pro Gly Lys Ala Pro Lys Ser Leu Ile 
        35                  40                  45              


Tyr Ser Ala Ser Tyr Arg Tyr Ser Gly Val Pro Ser Arg Phe Ser Gly 
    50                  55                  60                  


Ser Gly Ser Gly Thr Asp Phe Thr Leu Thr Ile Ser Ser Leu Gln Pro 
65                  70                  75                  80  


Glu Asp Phe Ala Thr Tyr Tyr Cys Ser Gln Val Asn Ser Tyr Asn Thr 
                85                  90                  95      


Phe Gly Gly Gly Thr Lys Val Glu Ile Lys 
            100                 105     


<210>  208
<211>  106
<212>  PRT
<213>  artificial sequence

<220>
<223>  3E6 VL0-v2

<400>  208

Asp Ile Gln Met Thr Gln Ser Pro Ser Ser Leu Ser Ala Ser Val Gly 
1               5                   10                  15      


Asp Arg Val Thr Ile Thr Cys Lys Ala Ser Gln Asn Val Gly Ala Asn 
            20                  25                  30          


Val Ala Trp Tyr Gln Gln Lys Pro Gly Lys Ala Pro Lys Ser Leu Ile 
        35                  40                  45              


Tyr Ser Ala Ser Tyr Arg Tyr Ser Gly Val Pro Ser Arg Phe Ser Gly 
    50                  55                  60                  


Ser Gly Ser Gly Thr Asp Phe Thr Leu Thr Ile Ser Ser Leu Gln Pro 
65                  70                  75                  80  


Glu Asp Phe Ala Thr Tyr Tyr Cys Glu Gln Val Asn Ser Tyr Pro Thr 
                85                  90                  95      


Phe Gly Gly Gly Thr Lys Val Glu Ile Lys 
            100                 105     


<210>  209
<211>  106
<212>  PRT
<213>  artificial sequence

<220>
<223>  3E6 VL0-v3

<400>  209

Asp Ile Gln Met Thr Gln Ser Pro Ser Ser Leu Ser Ala Ser Val Gly 
1               5                   10                  15      


Asp Arg Val Thr Ile Thr Cys Lys Ala Ser Gln Asn Val Gly Ala Asn 
            20                  25                  30          


Val Ala Trp Tyr Gln Gln Lys Pro Gly Lys Ala Pro Lys Ser Leu Ile 
        35                  40                  45              


Tyr Ser Ala Ser Tyr Arg Tyr Ser Gly Val Pro Ser Arg Phe Ser Gly 
    50                  55                  60                  


Ser Gly Ser Gly Thr Asp Phe Thr Leu Thr Ile Ser Ser Leu Gln Pro 
65                  70                  75                  80  


Glu Asp Phe Ala Thr Tyr Tyr Cys Ser Gln Tyr Asn Pro Tyr Asn Thr 
                85                  90                  95      


Phe Gly Gly Gly Thr Lys Val Glu Ile Lys 
            100                 105     


<210>  210
<211>  106
<212>  PRT
<213>  artificial sequence

<220>
<223>  3E6 VL0-v4

<400>  210

Asp Ile Gln Met Thr Gln Ser Pro Ser Ser Leu Ser Ala Ser Val Gly 
1               5                   10                  15      


Asp Arg Val Thr Ile Thr Cys Lys Ala Ser Gln Asn Val Gly Ala Asn 
            20                  25                  30          


Val Ala Trp Tyr Gln Gln Lys Pro Gly Lys Ala Pro Lys Ser Leu Ile 
        35                  40                  45              


Tyr Ser Ala Ser Tyr Arg Tyr Ser Gly Val Pro Ser Arg Phe Ser Gly 
    50                  55                  60                  


Ser Gly Ser Gly Thr Asp Phe Thr Leu Thr Ile Ser Ser Leu Gln Pro 
65                  70                  75                  80  


Glu Asp Phe Ala Thr Tyr Tyr Cys Ser Gln Val Asn Pro Tyr Asn Thr 
                85                  90                  95      


Phe Gly Gly Gly Thr Lys Val Glu Ile Lys 
            100                 105     


<210>  211
<211>  106
<212>  PRT
<213>  artificial sequence

<220>
<223>  3E6 VL0-v5

<400>  211

Asp Ile Gln Met Thr Gln Ser Pro Ser Ser Leu Ser Ala Ser Val Gly 
1               5                   10                  15      


Asp Arg Val Thr Ile Thr Cys Lys Ala Ser Gln Asn Val Gly Ala Asn 
            20                  25                  30          


Val Ala Trp Tyr Gln Gln Lys Pro Gly Lys Ala Pro Lys Ser Leu Ile 
        35                  40                  45              


Tyr Ser Ala Ser Tyr Arg Tyr Ser Gly Val Pro Ser Arg Phe Ser Gly 
    50                  55                  60                  


Ser Gly Ser Gly Thr Asp Phe Thr Leu Thr Ile Ser Ser Leu Gln Pro 
65                  70                  75                  80  


Glu Asp Phe Ala Thr Tyr Tyr Cys Glu Gln Val Asn Pro Tyr Pro Thr 
                85                  90                  95      


Phe Gly Gly Gly Thr Lys Val Glu Ile Lys 
            100                 105     


<210>  212
<211>  106
<212>  PRT
<213>  artificial sequence

<220>
<223>  3E6 VL0-v6

<400>  212

Asp Ile Gln Met Thr Gln Ser Pro Ser Ser Leu Ser Ala Ser Val Gly 
1               5                   10                  15      


Asp Arg Val Thr Ile Thr Cys Lys Ala Ser Gln Asn Val Gly Ala Asn 
            20                  25                  30          


Val Ala Trp Tyr Gln Gln Lys Pro Gly Lys Ala Pro Lys Ser Leu Ile 
        35                  40                  45              


Tyr Ser Ala Ser Tyr Arg Tyr Ser Gly Val Pro Ser Arg Phe Ser Gly 
    50                  55                  60                  


Ser Gly Ser Gly Thr Asp Phe Thr Leu Thr Ile Ser Ser Leu Gln Pro 
65                  70                  75                  80  


Glu Asp Phe Ala Thr Tyr Tyr Cys Gln Gln Val Asn Pro Tyr Pro Thr 
                85                  90                  95      


Phe Gly Gly Gly Thr Lys Val Glu Ile Lys 
            100                 105     


<210>  213
<211>  106
<212>  PRT
<213>  artificial sequence

<220>
<223>  3E6 VL0-v7

<400>  213

Asp Ile Gln Met Thr Gln Ser Pro Ser Ser Leu Ser Ala Ser Val Gly 
1               5                   10                  15      


Asp Arg Val Thr Ile Thr Cys Lys Ala Ser Gln Asn Val Gly Ala Asn 
            20                  25                  30          


Val Ala Trp Tyr Gln Gln Lys Pro Gly Lys Ala Pro Lys Ser Leu Ile 
        35                  40                  45              


Tyr Ser Ala Ser Tyr Arg Tyr Ser Gly Val Pro Ser Arg Phe Ser Gly 
    50                  55                  60                  


Ser Gly Ser Gly Thr Asp Phe Thr Leu Thr Ile Ser Ser Leu Gln Pro 
65                  70                  75                  80  


Glu Asp Phe Ala Thr Tyr Tyr Cys Glu Gln Tyr Asn Pro Tyr Pro Thr 
                85                  90                  95      


Phe Gly Gly Gly Thr Lys Val Glu Ile Lys 
            100                 105     


<210>  214
<211>  106
<212>  PRT
<213>  artificial sequence

<220>
<223>  3E6 VL0-v8

<400>  214

Asp Ile Gln Met Thr Gln Ser Pro Ser Ser Leu Ser Ala Ser Val Gly 
1               5                   10                  15      


Asp Arg Val Thr Ile Thr Cys Lys Ala Ser Gln Asn Val Gly Ala Asn 
            20                  25                  30          


Val Ala Trp Tyr Gln Gln Lys Pro Gly Lys Ala Pro Lys Ser Leu Ile 
        35                  40                  45              


Tyr Ser Ala Ser Tyr Arg Tyr Ser Gly Val Pro Ser Arg Phe Ser Gly 
    50                  55                  60                  


Ser Gly Ser Gly Thr Asp Phe Thr Leu Thr Ile Ser Ser Leu Gln Pro 
65                  70                  75                  80  


Glu Asp Phe Ala Thr Tyr Tyr Cys Ser Gln Val Asn Ser Tyr Pro Thr 
                85                  90                  95      


Phe Gly Gly Gly Thr Lys Val Glu Ile Lys 
            100                 105     


<210>  215
<211>  106
<212>  PRT
<213>  artificial sequence

<220>
<223>  3E6 VL0-v9

<400>  215

Asp Ile Gln Met Thr Gln Ser Pro Ser Ser Leu Ser Ala Ser Val Gly 
1               5                   10                  15      


Asp Arg Val Thr Ile Thr Cys Lys Ala Ser Gln Asn Val Gly Ala Asn 
            20                  25                  30          


Val Ala Trp Tyr Gln Gln Lys Pro Gly Lys Ala Pro Lys Ser Leu Ile 
        35                  40                  45              


Tyr Ser Ala Ser Tyr Arg Tyr Ser Gly Val Pro Ser Arg Phe Ser Gly 
    50                  55                  60                  


Ser Gly Ser Gly Thr Asp Phe Thr Leu Thr Ile Ser Ser Leu Gln Pro 
65                  70                  75                  80  


Glu Asp Phe Ala Thr Tyr Tyr Cys Glu Gln Val Gln Ser Tyr Pro Thr 
                85                  90                  95      


Phe Gly Gly Gly Thr Lys Val Glu Ile Lys 
            100                 105     


<210>  216
<211>  5
<212>  PRT
<213>  artificial sequence

<220>
<223>  Linker


<220>
<221>  REPEAT
<222>  (1)..(5)
<223>  (GGGGS)n, n=1,2,3,4, or 5

<220>
<221>  REPEAT
<222>  (1)..(5)
<223>  (GGGGS)n, n=1,2,3,4, or 5

<400>  216

Gly Gly Gly Gly Ser 
1               5   


<210>  217
<211>  5
<212>  PRT
<213>  artificial sequence

<220>
<223>  Linker


<220>
<221>  REPEAT
<222>  (1)..(5)
<223>  (EAAAK)n, n=1,2,3,4, or 5

<400>  217

Glu Ala Ala Ala Lys 
1               5   


