                       б

<110>  ϺҽҩŹɷ޹˾

<120>  Siglec15弰;

<130> 0124-PA-018

<160>  73

<170>  PatentIn version 3.5

<210>  1
<211>  30
<212>  PRT
<213>  ˹УArtificial Sequence

<220>
<223>  Ab0 H-FR1

<400>  1

Gln Ile Gln Leu Val Gln Ser Gly Pro Glu Leu Lys Lys Pro Gly Glu 
1               5                   10                  15      


Thr Val Lys Ile Ser Cys Lys Ala Ser Gly Tyr Thr Phe Thr 
            20                  25                  30  


<210>  2
<211>  30
<212>  PRT
<213>  ˹УArtificial Sequence

<220>
<223>  Ab1 H-FR1; Ab2 H-FR1; Ab3 H-FR1; Ab4 H-FR1; Ab5 H-FR1; Ab6 H-FR1

<400>  2

Gln Val Gln Leu Val Gln Ser Gly Ser Glu Leu Lys Lys Pro Gly Ala 
1               5                   10                  15      


Ser Val Lys Val Ser Cys Lys Ala Ser Gly Tyr Thr Phe Thr 
            20                  25                  30  


<210>  3
<211>  30
<212>  PRT
<213>  ˹УArtificial Sequence

<220>
<223>  Ab7 H-FR1; Ab8 H-FR1; Ab9 H-FR1

<400>  3

Gln Ile Gln Leu Val Gln Ser Gly Ser Glu Leu Lys Lys Pro Gly Ala 
1               5                   10                  15      


Ser Val Lys Val Ser Cys Lys Ala Ser Gly Tyr Thr Phe Thr 
            20                  25                  30  


<210>  4
<211>  5
<212>  PRT
<213>  ˹УArtificial Sequence

<220>
<223>  Ab0 HCDR1; Ab1 HCDR1; Ab2 HCDR1; Ab3 HCDR1; Ab4 HCDR1; Ab5 HCDR1; Ab6 HCDR1; Ab7 HCDR1; Ab8 HCDR1; Ab9 HCDR1

<400>  4

Thr Tyr Glu Met Ser 
1               5   


<210>  5
<211>  14
<212>  PRT
<213>  ˹УArtificial Sequence

<220>
<223>  Ab0 H-FR2

<400>  5

Trp Val Lys Gln Ala Pro Gly Lys Gly Leu Lys Trp Met Gly 
1               5                   10                  


<210>  6
<211>  14
<212>  PRT
<213>  ˹УArtificial Sequence

<220>
<223>  Ab1 H-FR2; Ab2 H-FR2; Ab3 H-FR2

<400>  6

Trp Val Arg Gln Ala Pro Gly Gln Gly Leu Glu Trp Met Gly 
1               5                   10                  


<210>  7
<211>  14
<212>  PRT
<213>  ˹УArtificial Sequence

<220>
<223>  Ab4 H-FR2; Ab5 H-FR2; Ab6 H-FR2

<400>  7

Trp Val Arg Gln Ala Pro Gly Gln Gly Leu Lys Trp Met Gly 
1               5                   10                  


<210>  8
<211>  14
<212>  PRT
<213>  ˹УArtificial Sequence

<220>
<223>  Ab7 H-FR2; Ab8 H-FR2; Ab9 H-FR2

<400>  8

Trp Val Lys Gln Ala Pro Gly Gln Gly Leu Lys Trp Met Gly 
1               5                   10                  


<210>  9
<211>  17
<212>  PRT
<213>  ˹УArtificial Sequence

<220>
<223>  Ab0 HCDR2; Ab1 HCDR2; Ab2 HCDR2; Ab3 HCDR2; Ab4 HCDR2; Ab5 HCDR2; Ab6 HCDR2; Ab7 HCDR2; Ab8 HCDR2; Ab9 HCDR2

<400>  9

Trp Ile Asn Thr Tyr Ser Gly Val Pro Thr Tyr Ala Asp Asp Phe Lys 
1               5                   10                  15      


Gly 
    


<210>  10
<211>  32
<212>  PRT
<213>  ˹УArtificial Sequence

<220>
<223>  Ab0 H-FR3

<400>  10

Arg Phe Ala Phe Ser Leu Glu Thr Ser Ala Ser Thr Ala Tyr Leu Gln 
1               5                   10                  15      


Ile Asn Asn Leu Lys Asn Glu Asp Thr Ala Thr Tyr Phe Cys Ala Arg 
            20                  25                  30          


<210>  11
<211>  32
<212>  PRT
<213>  ˹УArtificial Sequence

<220>
<223>  Ab1 H-FR3; Ab2 H-FR3; Ab3 H-FR3

<400>  11

Arg Phe Val Phe Ser Leu Asp Thr Ser Val Ser Met Ala Tyr Leu Gln 
1               5                   10                  15      


Ile Ser Ser Leu Lys Ala Glu Asp Thr Ala Val Tyr Tyr Cys Ala Arg 
            20                  25                  30          


<210>  12
<211>  32
<212>  PRT
<213>  ˹УArtificial Sequence

<220>
<223>  Ab4 H-FR3; Ab5 H-FR3; Ab6 H-FR3; Ab7 H-FR3; Ab8 H-FR3; Ab9 H-FR3

<400>  12

Arg Phe Val Phe Ser Leu Asp Thr Ser Val Ser Met Ala Tyr Leu Gln 
1               5                   10                  15      


Ile Ser Ser Leu Lys Ala Glu Asp Thr Ala Val Tyr Phe Cys Ala Arg 
            20                  25                  30          


<210>  13
<211>  11
<212>  PRT
<213>  ˹УArtificial Sequence

<220>
<223>  Ab0 HCDR3; Ab1 HCDR3; Ab2 HCDR3; Ab3 HCDR3; Ab4 HCDR3; Ab5 HCDR3; Ab6 HCDR3; Ab7 HCDR3; Ab8 HCDR3; Ab9 HCDR3

<400>  13

Glu Gly Val Tyr Asp Tyr Pro Tyr Phe Asp Ser 
1               5                   10      


<210>  14
<211>  11
<212>  PRT
<213>  ˹УArtificial Sequence

<220>
<223>  Ab0 H-FR4

<400>  14

Trp Gly Gln Gly Thr Thr Leu Thr Val Ser Ser 
1               5                   10      


<210>  15
<211>  11
<212>  PRT
<213>  ˹УArtificial Sequence

<220>
<223>  Ab1 H-FR4; Ab2 H-FR4; Ab3 H-FR4; Ab4 H-FR4; Ab5 H-FR4; Ab6 H-FR4; Ab7 H-FR4; Ab8 H-FR4; Ab9 H-FR4

<400>  15

Trp Gly Gln Gly Thr Leu Val Thr Val Ser Ser 
1               5                   10      


<210>  16
<211>  23
<212>  PRT
<213>  ˹УArtificial Sequence

<220>
<223>  Ab0 L-FR1


<400>  16

Asp Ile Gln Met Asn Gln Ser Pro Ser Ser Leu Ser Ala Ser Leu Gly 
1               5                   10                  15      


Asp Thr Ile Thr Ile Thr Cys 
            20              


<210>  17
<211>  23
<212>  PRT
<213>  ˹УArtificial Sequence

<220>
<223>  Ab1 L-FR1; Ab4 L-FR1; Ab7 L-FR1

<400>  17

Asp Ile Gln Met Thr Gln Ser Pro Ser Ser Leu Ser Ala Ser Val Gly 
1               5                   10                  15      


Asp Arg Val Thr Ile Thr Cys 
            20              


<210>  18
<211>  23
<212>  PRT
<213>  ˹УArtificial Sequence

<220>
<223>  Ab2 L-FR1; Ab3 L-FR1; Ab5 L-FR1; Ab6 L-FR1; Ab8 L-FR1; Ab9 L-FR1

<400>  18

Asp Ile Gln Met Asn Gln Ser Pro Ser Ser Leu Ser Ala Ser Val Gly 
1               5                   10                  15      


Asp Arg Val Thr Ile Thr Cys 
            20              


<210>  19
<211>  11
<212>  PRT
<213>  ˹УArtificial Sequence

<220>
<223>  Ab0 LCDR1; Ab1 LCDR1; Ab2 LCDR1; Ab3 LCDR1; Ab4 LCDR1; Ab5 LCDR1; Ab6 LCDR1; Ab7 LCDR1; Ab8 LCDR1; Ab9 LCDR1

<400>  19

His Ala Ser Gln Asn Ile Asn Val Trp Leu Ser 
1               5                   10      


<210>  20
<211>  15
<212>  PRT
<213>  ˹УArtificial Sequence

<220>
<223>  Ab0 L-FR2; Ab3 L-FR2; Ab6 L-FR2; Ab9 L-FR2

<400>  20

Trp Tyr Gln Gln Lys Pro Gly Asn Ile Pro Lys Leu Leu Ile Tyr 
1               5                   10                  15  


<210>  21
<211>  15
<212>  PRT
<213>  ˹УArtificial Sequence

<220>
<223>   Ab1 L-FR2; Ab2 L-FR2; Ab4 L-FR2; Ab5 L-FR2; Ab7 L-FR2; Ab8 L-FR2

<400>  21

Trp Tyr Gln Gln Lys Pro Gly Lys Ala Pro Lys Leu Leu Ile Tyr 
1               5                   10                  15  


<210>  22
<211>  7
<212>  PRT
<213>  ˹УArtificial Sequence

<220>
<223>  Ab0 LCDR2; Ab1 LCDR2; Ab2 LCDR2; Ab3 LCDR2; Ab4 LCDR2; Ab5 LCDR2; Ab6 LCDR2; Ab7 LCDR2; Ab8 LCDR2; Ab9 LCDR2

<400>  22

Lys Ala Ser Asn Leu His Thr 
1               5           


<210>  23
<211>  32
<212>  PRT
<213>  ˹УArtificial Sequence

<220>
<223>  Ab0 L-FR3

<400>  23

Gly Val Pro Ser Arg Phe Ser Gly Ser Gly Ser Arg Thr Gly Phe Thr 
1               5                   10                  15      


Leu Thr Ile Ser Ser Leu Gln Pro Glu Asp Ile Ala Thr Tyr Tyr Cys 
            20                  25                  30          


<210>  24
<211>  32
<212>  PRT
<213>  ˹УArtificial Sequence

<220>
<223>  Ab1 L-FR3; Ab4 L-FR3; Ab7 L-FR3

<400>  24

Gly Val Pro Ser Arg Phe Ser Gly Ser Gly Ser Gly Thr Asp Phe Thr 
1               5                   10                  15      


Leu Thr Ile Ser Ser Leu Gln Pro Glu Asp Phe Ala Thr Tyr Tyr Cys 
            20                  25                  30          


<210>  25
<211>  32
<212>  PRT
<213>  ˹УArtificial Sequence

<220>
<223>  Ab2 L-FR3; Ab3 L-FR3; Ab5 L-FR3; Ab6 L-FR3; Ab8 L-FR3; Ab9 L-FR3

<400>  25

Gly Val Pro Ser Arg Phe Ser Gly Ser Gly Ser Arg Thr Asp Phe Thr 
1               5                   10                  15      


Leu Thr Ile Ser Ser Leu Gln Pro Glu Asp Phe Ala Thr Tyr Tyr Cys 
            20                  25                  30          


<210>  26
<211>  9
<212>  PRT
<213>  ˹УArtificial Sequence

<220>
<223>  Ab0 LCDR3; Ab1 LCDR3; Ab2 LCDR3; Ab3 LCDR3; Ab4 LCDR3; Ab5 LCDR3; Ab6 LCDR3; Ab7 LCDR3; Ab8 LCDR3; Ab9 LCDR3

<400>  26

Gln Gln Gly Gln Ser Ser Pro Leu Thr 
1               5                   


<210>  27
<211>  10
<212>  PRT
<213>  ˹УArtificial Sequence

<220>
<223>  Ab0 L-FR4

<400>  27

Phe Gly Gly Gly Thr Lys Leu Glu Ile Lys 
1               5                   10  


<210>  28
<211>  10
<212>  PRT
<213>  ˹УArtificial Sequence

<220>
<223>  Ab1 L-FR4; Ab2 L-FR4; Ab3 L-FR4; Ab4 L-FR4; Ab5 L-FR4; Ab6 L-FR4; Ab7 L-FR4; Ab8 L-FR4; Ab9 L-FR4

<400>  28

Phe Gly Gly Gly Thr Lys Val Glu Ile Lys 
1               5                   10  


<210>  29
<211>  120
<212>  PRT
<213>  ˹УArtificial Sequence

<220>
<223>  Ab0 VH

<400>  29

Gln Ile Gln Leu Val Gln Ser Gly Pro Glu Leu Lys Lys Pro Gly Glu 
1               5                   10                  15      


Thr Val Lys Ile Ser Cys Lys Ala Ser Gly Tyr Thr Phe Thr Thr Tyr 
            20                  25                  30          


Glu Met Ser Trp Val Lys Gln Ala Pro Gly Lys Gly Leu Lys Trp Met 
        35                  40                  45              


Gly Trp Ile Asn Thr Tyr Ser Gly Val Pro Thr Tyr Ala Asp Asp Phe 
    50                  55                  60                  


Lys Gly Arg Phe Ala Phe Ser Leu Glu Thr Ser Ala Ser Thr Ala Tyr 
65                  70                  75                  80  


Leu Gln Ile Asn Asn Leu Lys Asn Glu Asp Thr Ala Thr Tyr Phe Cys 
                85                  90                  95      


Ala Arg Glu Gly Val Tyr Asp Tyr Pro Tyr Phe Asp Ser Trp Gly Gln 
            100                 105                 110         


Gly Thr Thr Leu Thr Val Ser Ser 
        115                 120 


<210>  30
<211>  120
<212>  PRT
<213>  ˹УArtificial Sequence

<220>
<223>  Ab1 VH; Ab2 VH; Ab3 VH

<400>  30

Gln Val Gln Leu Val Gln Ser Gly Ser Glu Leu Lys Lys Pro Gly Ala 
1               5                   10                  15      


Ser Val Lys Val Ser Cys Lys Ala Ser Gly Tyr Thr Phe Thr Thr Tyr 
            20                  25                  30          


Glu Met Ser Trp Val Arg Gln Ala Pro Gly Gln Gly Leu Glu Trp Met 
        35                  40                  45              


Gly Trp Ile Asn Thr Tyr Ser Gly Val Pro Thr Tyr Ala Asp Asp Phe 
    50                  55                  60                  


Lys Gly Arg Phe Val Phe Ser Leu Asp Thr Ser Val Ser Met Ala Tyr 
65                  70                  75                  80  


Leu Gln Ile Ser Ser Leu Lys Ala Glu Asp Thr Ala Val Tyr Tyr Cys 
                85                  90                  95      


Ala Arg Glu Gly Val Tyr Asp Tyr Pro Tyr Phe Asp Ser Trp Gly Gln 
            100                 105                 110         


Gly Thr Leu Val Thr Val Ser Ser 
        115                 120 


<210>  31
<211>  120
<212>  PRT
<213>  ˹УArtificial Sequence

<220>
<223>  Ab4 VH; Ab5 VH; Ab6 VH

<400>  31

Gln Val Gln Leu Val Gln Ser Gly Ser Glu Leu Lys Lys Pro Gly Ala 
1               5                   10                  15      


Ser Val Lys Val Ser Cys Lys Ala Ser Gly Tyr Thr Phe Thr Thr Tyr 
            20                  25                  30          


Glu Met Ser Trp Val Arg Gln Ala Pro Gly Gln Gly Leu Lys Trp Met 
        35                  40                  45              


Gly Trp Ile Asn Thr Tyr Ser Gly Val Pro Thr Tyr Ala Asp Asp Phe 
    50                  55                  60                  


Lys Gly Arg Phe Val Phe Ser Leu Asp Thr Ser Val Ser Met Ala Tyr 
65                  70                  75                  80  


Leu Gln Ile Ser Ser Leu Lys Ala Glu Asp Thr Ala Val Tyr Phe Cys 
                85                  90                  95      


Ala Arg Glu Gly Val Tyr Asp Tyr Pro Tyr Phe Asp Ser Trp Gly Gln 
            100                 105                 110         


Gly Thr Leu Val Thr Val Ser Ser 
        115                 120 


<210>  32
<211>  120
<212>  PRT
<213>  ˹УArtificial Sequence

<220>
<223>  Ab7 VH; Ab8 VH; Ab9 VH

<400>  32

Gln Ile Gln Leu Val Gln Ser Gly Ser Glu Leu Lys Lys Pro Gly Ala 
1               5                   10                  15      


Ser Val Lys Val Ser Cys Lys Ala Ser Gly Tyr Thr Phe Thr Thr Tyr 
            20                  25                  30          


Glu Met Ser Trp Val Lys Gln Ala Pro Gly Gln Gly Leu Lys Trp Met 
        35                  40                  45              


Gly Trp Ile Asn Thr Tyr Ser Gly Val Pro Thr Tyr Ala Asp Asp Phe 
    50                  55                  60                  


Lys Gly Arg Phe Val Phe Ser Leu Asp Thr Ser Val Ser Met Ala Tyr 
65                  70                  75                  80  


Leu Gln Ile Ser Ser Leu Lys Ala Glu Asp Thr Ala Val Tyr Phe Cys 
                85                  90                  95      


Ala Arg Glu Gly Val Tyr Asp Tyr Pro Tyr Phe Asp Ser Trp Gly Gln 
            100                 105                 110         


Gly Thr Leu Val Thr Val Ser Ser 
        115                 120 


<210>  33
<211>  107
<212>  PRT
<213>  ˹УArtificial Sequence

<220>
<223>  Ab0 VL

<400>  33

Asp Ile Gln Met Asn Gln Ser Pro Ser Ser Leu Ser Ala Ser Leu Gly 
1               5                   10                  15      


Asp Thr Ile Thr Ile Thr Cys His Ala Ser Gln Asn Ile Asn Val Trp 
            20                  25                  30          


Leu Ser Trp Tyr Gln Gln Lys Pro Gly Asn Ile Pro Lys Leu Leu Ile 
        35                  40                  45              


Tyr Lys Ala Ser Asn Leu His Thr Gly Val Pro Ser Arg Phe Ser Gly 
    50                  55                  60                  


Ser Gly Ser Arg Thr Gly Phe Thr Leu Thr Ile Ser Ser Leu Gln Pro 
65                  70                  75                  80  


Glu Asp Ile Ala Thr Tyr Tyr Cys Gln Gln Gly Gln Ser Ser Pro Leu 
                85                  90                  95      


Thr Phe Gly Gly Gly Thr Lys Leu Glu Ile Lys 
            100                 105         


<210>  34
<211>  107
<212>  PRT
<213>  ˹УArtificial Sequence

<220>
<223>  Ab1 VL; Ab4 VL; Ab7 VL

<400>  34

Asp Ile Gln Met Thr Gln Ser Pro Ser Ser Leu Ser Ala Ser Val Gly 
1               5                   10                  15      


Asp Arg Val Thr Ile Thr Cys His Ala Ser Gln Asn Ile Asn Val Trp 
            20                  25                  30          


Leu Ser Trp Tyr Gln Gln Lys Pro Gly Lys Ala Pro Lys Leu Leu Ile 
        35                  40                  45              


Tyr Lys Ala Ser Asn Leu His Thr Gly Val Pro Ser Arg Phe Ser Gly 
    50                  55                  60                  


Ser Gly Ser Gly Thr Asp Phe Thr Leu Thr Ile Ser Ser Leu Gln Pro 
65                  70                  75                  80  


Glu Asp Phe Ala Thr Tyr Tyr Cys Gln Gln Gly Gln Ser Ser Pro Leu 
                85                  90                  95      


Thr Phe Gly Gly Gly Thr Lys Val Glu Ile Lys 
            100                 105         


<210>  35
<211>  107
<212>  PRT
<213>  ˹УArtificial Sequence

<220>
<223>  Ab2 VL; Ab5 VL; Ab8 VL

<400>  35

Asp Ile Gln Met Asn Gln Ser Pro Ser Ser Leu Ser Ala Ser Val Gly 
1               5                   10                  15      


Asp Arg Val Thr Ile Thr Cys His Ala Ser Gln Asn Ile Asn Val Trp 
            20                  25                  30          


Leu Ser Trp Tyr Gln Gln Lys Pro Gly Lys Ala Pro Lys Leu Leu Ile 
        35                  40                  45              


Tyr Lys Ala Ser Asn Leu His Thr Gly Val Pro Ser Arg Phe Ser Gly 
    50                  55                  60                  


Ser Gly Ser Arg Thr Asp Phe Thr Leu Thr Ile Ser Ser Leu Gln Pro 
65                  70                  75                  80  


Glu Asp Phe Ala Thr Tyr Tyr Cys Gln Gln Gly Gln Ser Ser Pro Leu 
                85                  90                  95      


Thr Phe Gly Gly Gly Thr Lys Val Glu Ile Lys 
            100                 105         


<210>  36
<211>  107
<212>  PRT
<213>  ˹УArtificial Sequence

<220>
<223>  Ab3 VL; Ab6 VL; Ab9 VL

<400>  36

Asp Ile Gln Met Asn Gln Ser Pro Ser Ser Leu Ser Ala Ser Val Gly 
1               5                   10                  15      


Asp Arg Val Thr Ile Thr Cys His Ala Ser Gln Asn Ile Asn Val Trp 
            20                  25                  30          


Leu Ser Trp Tyr Gln Gln Lys Pro Gly Asn Ile Pro Lys Leu Leu Ile 
        35                  40                  45              


Tyr Lys Ala Ser Asn Leu His Thr Gly Val Pro Ser Arg Phe Ser Gly 
    50                  55                  60                  


Ser Gly Ser Arg Thr Asp Phe Thr Leu Thr Ile Ser Ser Leu Gln Pro 
65                  70                  75                  80  


Glu Asp Phe Ala Thr Tyr Tyr Cys Gln Gln Gly Gln Ser Ser Pro Leu 
                85                  90                  95      


Thr Phe Gly Gly Gly Thr Lys Val Glu Ile Lys 
            100                 105         


<210>  37
<211>  122
<212>  PRT
<213>  ˹УArtificial Sequence

<220>
<223>  Զտɱ

<400>  37

Gln Val Gln Leu Gln Gln Pro Gly Ala Glu Leu Val Lys Pro Gly Ala 
1               5                   10                  15      


Ser Val Lys Met Ser Cys Lys Ala Ser Gly Tyr Thr Phe Thr Ser Tyr 
            20                  25                  30          


Trp Ile Thr Trp Val Ile Gln Arg Pro Gly Gln Gly Leu Glu Trp Ile 
        35                  40                  45              


Gly Asp Ile Tyr Cys Gly Ser Asp Thr Met His Tyr Asn Glu Lys Phe 
    50                  55                  60                  


Lys Asn Lys Ala Thr Leu Thr Val Asp Thr Ser Ser Ser Thr Ala Tyr 
65                  70                  75                  80  


Met Gln Leu Ser Ser Leu Thr Ser Glu Asp Ser Ala Val Tyr Tyr Cys 
                85                  90                  95      


Ala Arg Trp Trp Asp Tyr Gly Ser Ser Tyr Asp Tyr Phe Asp Tyr Trp 
            100                 105                 110         


Gly Gln Gly Thr Thr Leu Thr Val Ser Ser 
        115                 120         


<210>  38
<211>  107
<212>  PRT
<213>  ˹УArtificial Sequence

<220>
<223>  Զտɱ

<400>  38

Asp Ile Lys Met Thr Gln Ser Pro Ser Ser Met Tyr Ala Ser Leu Gly 
1               5                   10                  15      


Glu Arg Val Thr Ile Thr Cys Lys Ala Ser Gln Asp Ile Asn Ser Tyr 
            20                  25                  30          


Leu Ser Trp Phe Gln Gln Lys Pro Gly Lys Ser Pro Lys Thr Leu Ile 
        35                  40                  45              


Tyr Arg Ala Asn Arg Leu Val Asp Gly Val Pro Ser Arg Phe Ser Gly 
    50                  55                  60                  


Ser Gly Ser Gly Gln Asp Tyr Ser Leu Thr Ile Ser Ser Leu Glu Tyr 
65                  70                  75                  80  


Glu Asp Met Gly Ile Tyr Tyr Cys Leu Gln Tyr Asp Glu Phe Pro Tyr 
                85                  90                  95      


Thr Phe Gly Gly Gly Thr Lys Leu Glu Ile Lys 
            100                 105         


<210>  39
<211>  330
<212>  PRT
<213>  ࣨHomo sapiens

<400>  39

Ala Ser Thr Lys Gly Pro Ser Val Phe Pro Leu Ala Pro Ser Ser Lys 
1               5                   10                  15      


Ser Thr Ser Gly Gly Thr Ala Ala Leu Gly Cys Leu Val Lys Asp Tyr 
            20                  25                  30          


Phe Pro Glu Pro Val Thr Val Ser Trp Asn Ser Gly Ala Leu Thr Ser 
        35                  40                  45              


Gly Val His Thr Phe Pro Ala Val Leu Gln Ser Ser Gly Leu Tyr Ser 
    50                  55                  60                  


Leu Ser Ser Val Val Thr Val Pro Ser Ser Ser Leu Gly Thr Gln Thr 
65                  70                  75                  80  


Tyr Ile Cys Asn Val Asn His Lys Pro Ser Asn Thr Lys Val Asp Lys 
                85                  90                  95      


Lys Val Glu Pro Lys Ser Cys Asp Lys Thr His Thr Cys Pro Pro Cys 
            100                 105                 110         


Pro Ala Pro Glu Leu Leu Gly Gly Pro Ser Val Phe Leu Phe Pro Pro 
        115                 120                 125             


Lys Pro Lys Asp Thr Leu Met Ile Ser Arg Thr Pro Glu Val Thr Cys 
    130                 135                 140                 


Val Val Val Asp Val Ser His Glu Asp Pro Glu Val Lys Phe Asn Trp 
145                 150                 155                 160 


Tyr Val Asp Gly Val Glu Val His Asn Ala Lys Thr Lys Pro Arg Glu 
                165                 170                 175     


Glu Gln Tyr Asn Ser Thr Tyr Arg Val Val Ser Val Leu Thr Val Leu 
            180                 185                 190         


His Gln Asp Trp Leu Asn Gly Lys Glu Tyr Lys Cys Lys Val Ser Asn 
        195                 200                 205             


Lys Ala Leu Pro Ala Pro Ile Glu Lys Thr Ile Ser Lys Ala Lys Gly 
    210                 215                 220                 


Gln Pro Arg Glu Pro Gln Val Tyr Thr Leu Pro Pro Ser Arg Glu Glu 
225                 230                 235                 240 


Met Thr Lys Asn Gln Val Ser Leu Thr Cys Leu Val Lys Gly Phe Tyr 
                245                 250                 255     


Pro Ser Asp Ile Ala Val Glu Trp Glu Ser Asn Gly Gln Pro Glu Asn 
            260                 265                 270         


Asn Tyr Lys Thr Thr Pro Pro Val Leu Asp Ser Asp Gly Ser Phe Phe 
        275                 280                 285             


Leu Tyr Ser Lys Leu Thr Val Asp Lys Ser Arg Trp Gln Gln Gly Asn 
    290                 295                 300                 


Val Phe Ser Cys Ser Val Met His Glu Ala Leu His Asn His Tyr Thr 
305                 310                 315                 320 


Gln Lys Ser Leu Ser Leu Ser Pro Gly Lys 
                325                 330 


<210>  40
<211>  326
<212>  PRT
<213>  ࣨHomo sapiens

<400>  40

Ala Ser Thr Lys Gly Pro Ser Val Phe Pro Leu Ala Pro Cys Ser Arg 
1               5                   10                  15      


Ser Thr Ser Glu Ser Thr Ala Ala Leu Gly Cys Leu Val Lys Asp Tyr 
            20                  25                  30          


Phe Pro Glu Pro Val Thr Val Ser Trp Asn Ser Gly Ala Leu Thr Ser 
        35                  40                  45              


Gly Val His Thr Phe Pro Ala Val Leu Gln Ser Ser Gly Leu Tyr Ser 
    50                  55                  60                  


Leu Ser Ser Val Val Thr Val Pro Ser Ser Asn Phe Gly Thr Gln Thr 
65                  70                  75                  80  


Tyr Thr Cys Asn Val Asp His Lys Pro Ser Asn Thr Lys Val Asp Lys 
                85                  90                  95      


Thr Val Glu Arg Lys Cys Cys Val Glu Cys Pro Pro Cys Pro Ala Pro 
            100                 105                 110         


Pro Val Ala Gly Pro Ser Val Phe Leu Phe Pro Pro Lys Pro Lys Asp 
        115                 120                 125             


Thr Leu Met Ile Ser Arg Thr Pro Glu Val Thr Cys Val Val Val Asp 
    130                 135                 140                 


Val Ser His Glu Asp Pro Glu Val Gln Phe Asn Trp Tyr Val Asp Gly 
145                 150                 155                 160 


Val Glu Val His Asn Ala Lys Thr Lys Pro Arg Glu Glu Gln Phe Asn 
                165                 170                 175     


Ser Thr Phe Arg Val Val Ser Val Leu Thr Val Val His Gln Asp Trp 
            180                 185                 190         


Leu Asn Gly Lys Glu Tyr Lys Cys Lys Val Ser Asn Lys Gly Leu Pro 
        195                 200                 205             


Ala Pro Ile Glu Lys Thr Ile Ser Lys Thr Lys Gly Gln Pro Arg Glu 
    210                 215                 220                 


Pro Gln Val Tyr Thr Leu Pro Pro Ser Arg Glu Glu Met Thr Lys Asn 
225                 230                 235                 240 


Gln Val Ser Leu Thr Cys Leu Val Lys Gly Phe Tyr Pro Ser Asp Ile 
                245                 250                 255     


Ala Val Glu Trp Glu Ser Asn Gly Gln Pro Glu Asn Asn Tyr Lys Thr 
            260                 265                 270         


Thr Pro Pro Met Leu Asp Ser Asp Gly Ser Phe Phe Leu Tyr Ser Lys 
        275                 280                 285             


Leu Thr Val Asp Lys Ser Arg Trp Gln Gln Gly Asn Val Phe Ser Cys 
    290                 295                 300                 


Ser Val Met His Glu Ala Leu His Asn His Tyr Thr Gln Lys Ser Leu 
305                 310                 315                 320 


Ser Leu Ser Pro Gly Lys 
                325     


<210>  41
<211>  377
<212>  PRT
<213>  ࣨHomo sapiens

<400>  41

Ala Ser Thr Lys Gly Pro Ser Val Phe Pro Leu Ala Pro Cys Ser Arg 
1               5                   10                  15      


Ser Thr Ser Gly Gly Thr Ala Ala Leu Gly Cys Leu Val Lys Asp Tyr 
            20                  25                  30          


Phe Pro Glu Pro Val Thr Val Ser Trp Asn Ser Gly Ala Leu Thr Ser 
        35                  40                  45              


Gly Val His Thr Phe Pro Ala Val Leu Gln Ser Ser Gly Leu Tyr Ser 
    50                  55                  60                  


Leu Ser Ser Val Val Thr Val Pro Ser Ser Ser Leu Gly Thr Gln Thr 
65                  70                  75                  80  


Tyr Thr Cys Asn Val Asn His Lys Pro Ser Asn Thr Lys Val Asp Lys 
                85                  90                  95      


Arg Val Glu Leu Lys Thr Pro Leu Gly Asp Thr Thr His Thr Cys Pro 
            100                 105                 110         


Arg Cys Pro Glu Pro Lys Ser Cys Asp Thr Pro Pro Pro Cys Pro Arg 
        115                 120                 125             


Cys Pro Glu Pro Lys Ser Cys Asp Thr Pro Pro Pro Cys Pro Arg Cys 
    130                 135                 140                 


Pro Glu Pro Lys Ser Cys Asp Thr Pro Pro Pro Cys Pro Arg Cys Pro 
145                 150                 155                 160 


Ala Pro Glu Leu Leu Gly Gly Pro Ser Val Phe Leu Phe Pro Pro Lys 
                165                 170                 175     


Pro Lys Asp Thr Leu Met Ile Ser Arg Thr Pro Glu Val Thr Cys Val 
            180                 185                 190         


Val Val Asp Val Ser His Glu Asp Pro Glu Val Gln Phe Lys Trp Tyr 
        195                 200                 205             


Val Asp Gly Val Glu Val His Asn Ala Lys Thr Lys Pro Arg Glu Glu 
    210                 215                 220                 


Gln Tyr Asn Ser Thr Phe Arg Val Val Ser Val Leu Thr Val Leu His 
225                 230                 235                 240 


Gln Asp Trp Leu Asn Gly Lys Glu Tyr Lys Cys Lys Val Ser Asn Lys 
                245                 250                 255     


Ala Leu Pro Ala Pro Ile Glu Lys Thr Ile Ser Lys Thr Lys Gly Gln 
            260                 265                 270         


Pro Arg Glu Pro Gln Val Tyr Thr Leu Pro Pro Ser Arg Glu Glu Met 
        275                 280                 285             


Thr Lys Asn Gln Val Ser Leu Thr Cys Leu Val Lys Gly Phe Tyr Pro 
    290                 295                 300                 


Ser Asp Ile Ala Val Glu Trp Glu Ser Ser Gly Gln Pro Glu Asn Asn 
305                 310                 315                 320 


Tyr Asn Thr Thr Pro Pro Met Leu Asp Ser Asp Gly Ser Phe Phe Leu 
                325                 330                 335     


Tyr Ser Lys Leu Thr Val Asp Lys Ser Arg Trp Gln Gln Gly Asn Ile 
            340                 345                 350         


Phe Ser Cys Ser Val Met His Glu Ala Leu His Asn Arg Phe Thr Gln 
        355                 360                 365             


Lys Ser Leu Ser Leu Ser Pro Gly Lys 
    370                 375         


<210>  42
<211>  327
<212>  PRT
<213>  ࣨHomo sapiens

<400>  42

Ala Ser Thr Lys Gly Pro Ser Val Phe Pro Leu Ala Pro Cys Ser Arg 
1               5                   10                  15      


Ser Thr Ser Glu Ser Thr Ala Ala Leu Gly Cys Leu Val Lys Asp Tyr 
            20                  25                  30          


Phe Pro Glu Pro Val Thr Val Ser Trp Asn Ser Gly Ala Leu Thr Ser 
        35                  40                  45              


Gly Val His Thr Phe Pro Ala Val Leu Gln Ser Ser Gly Leu Tyr Ser 
    50                  55                  60                  


Leu Ser Ser Val Val Thr Val Pro Ser Ser Ser Leu Gly Thr Lys Thr 
65                  70                  75                  80  


Tyr Thr Cys Asn Val Asp His Lys Pro Ser Asn Thr Lys Val Asp Lys 
                85                  90                  95      


Arg Val Glu Ser Lys Tyr Gly Pro Pro Cys Pro Ser Cys Pro Ala Pro 
            100                 105                 110         


Glu Phe Leu Gly Gly Pro Ser Val Phe Leu Phe Pro Pro Lys Pro Lys 
        115                 120                 125             


Asp Thr Leu Met Ile Ser Arg Thr Pro Glu Val Thr Cys Val Val Val 
    130                 135                 140                 


Asp Val Ser Gln Glu Asp Pro Glu Val Gln Phe Asn Trp Tyr Val Asp 
145                 150                 155                 160 


Gly Val Glu Val His Asn Ala Lys Thr Lys Pro Arg Glu Glu Gln Phe 
                165                 170                 175     


Asn Ser Thr Tyr Arg Val Val Ser Val Leu Thr Val Leu His Gln Asp 
            180                 185                 190         


Trp Leu Asn Gly Lys Glu Tyr Lys Cys Lys Val Ser Asn Lys Gly Leu 
        195                 200                 205             


Pro Ser Ser Ile Glu Lys Thr Ile Ser Lys Ala Lys Gly Gln Pro Arg 
    210                 215                 220                 


Glu Pro Gln Val Tyr Thr Leu Pro Pro Ser Gln Glu Glu Met Thr Lys 
225                 230                 235                 240 


Asn Gln Val Ser Leu Thr Cys Leu Val Lys Gly Phe Tyr Pro Ser Asp 
                245                 250                 255     


Ile Ala Val Glu Trp Glu Ser Asn Gly Gln Pro Glu Asn Asn Tyr Lys 
            260                 265                 270         


Thr Thr Pro Pro Val Leu Asp Ser Asp Gly Ser Phe Phe Leu Tyr Ser 
        275                 280                 285             


Arg Leu Thr Val Asp Lys Ser Arg Trp Gln Glu Gly Asn Val Phe Ser 
    290                 295                 300                 


Cys Ser Val Met His Glu Ala Leu His Asn His Tyr Thr Gln Lys Ser 
305                 310                 315                 320 


Leu Ser Leu Ser Leu Gly Lys 
                325         


<210>  43
<211>  107
<212>  PRT
<213>  ࣨHomo sapiens

<400>  43

Arg Thr Val Ala Ala Pro Ser Val Phe Ile Phe Pro Pro Ser Asp Glu 
1               5                   10                  15      


Gln Leu Lys Ser Gly Thr Ala Ser Val Val Cys Leu Leu Asn Asn Phe 
            20                  25                  30          


Tyr Pro Arg Glu Ala Lys Val Gln Trp Lys Val Asp Asn Ala Leu Gln 
        35                  40                  45              


Ser Gly Asn Ser Gln Glu Ser Val Thr Glu Gln Asp Ser Lys Asp Ser 
    50                  55                  60                  


Thr Tyr Ser Leu Ser Ser Thr Leu Thr Leu Ser Lys Ala Asp Tyr Glu 
65                  70                  75                  80  


Lys His Lys Val Tyr Ala Cys Glu Val Thr His Gln Gly Leu Ser Ser 
                85                  90                  95      


Pro Val Thr Lys Ser Phe Asn Arg Gly Glu Cys 
            100                 105         


<210>  44
<211>  5
<212>  PRT
<213>  ˹УArtificial Sequence

<220>
<223>  鵥 HCDR1

<400>  44

Asn Tyr Tyr Met Tyr 
1               5   


<210>  45
<211>  17
<212>  PRT
<213>  ˹УArtificial Sequence

<220>
<223>  鵥 HCDR2

<400>  45

Gly Ile Asn Pro Ser Asn Gly Gly Thr Asn Phe Asn Glu Lys Phe Lys 
1               5                   10                  15      


Asn 
    


<210>  46
<211>  11
<212>  PRT
<213>  ˹УArtificial Sequence

<220>
<223>  鵥 HCDR3

<400>  46

Arg Asp Tyr Arg Phe Asp Met Gly Phe Asp Tyr 
1               5                   10      


<210>  47
<211>  15
<212>  PRT
<213>  ˹УArtificial Sequence

<220>
<223>  鵥 LCDR1

<400>  47

Arg Ala Ser Lys Gly Val Ser Thr Ser Gly Tyr Ser Tyr Leu His 
1               5                   10                  15  


<210>  48
<211>  7
<212>  PRT
<213>  ˹УArtificial Sequence

<220>
<223>  鵥 LCDR2

<400>  48

Leu Ala Ser Tyr Leu Glu Ser 
1               5           


<210>  49
<211>  9
<212>  PRT
<213>  ˹УArtificial Sequence

<220>
<223>  鵥 LCDR3

<400>  49

Gln His Ser Arg Asp Leu Pro Leu Thr 
1               5                   


<210>  50
<211>  120
<212>  PRT
<213>  ˹УArtificial Sequence

<220>
<223>  鵥 VH

<400>  50

Gln Val Gln Leu Val Gln Ser Gly Val Glu Val Lys Lys Pro Gly Ala 
1               5                   10                  15      


Ser Val Lys Val Ser Cys Lys Ala Ser Gly Tyr Thr Phe Thr Asn Tyr 
            20                  25                  30          


Tyr Met Tyr Trp Val Arg Gln Ala Pro Gly Gln Gly Leu Glu Trp Met 
        35                  40                  45              


Gly Gly Ile Asn Pro Ser Asn Gly Gly Thr Asn Phe Asn Glu Lys Phe 
    50                  55                  60                  


Lys Asn Arg Val Thr Leu Thr Thr Asp Ser Ser Thr Thr Thr Ala Tyr 
65                  70                  75                  80  


Met Glu Leu Lys Ser Leu Gln Phe Asp Asp Thr Ala Val Tyr Tyr Cys 
                85                  90                  95      


Ala Arg Arg Asp Tyr Arg Phe Asp Met Gly Phe Asp Tyr Trp Gly Gln 
            100                 105                 110         


Gly Thr Thr Val Thr Val Ser Ser 
        115                 120 


<210>  51
<211>  111
<212>  PRT
<213>  ˹УArtificial Sequence

<220>
<223>  鵥 VL

<400>  51

Glu Ile Val Leu Thr Gln Ser Pro Ala Thr Leu Ser Leu Ser Pro Gly 
1               5                   10                  15      


Glu Arg Ala Thr Leu Ser Cys Arg Ala Ser Lys Gly Val Ser Thr Ser 
            20                  25                  30          


Gly Tyr Ser Tyr Leu His Trp Tyr Gln Gln Lys Pro Gly Gln Ala Pro 
        35                  40                  45              


Arg Leu Leu Ile Tyr Leu Ala Ser Tyr Leu Glu Ser Gly Val Pro Ala 
    50                  55                  60                  


Arg Phe Ser Gly Ser Gly Ser Gly Thr Asp Phe Thr Leu Thr Ile Ser 
65                  70                  75                  80  


Ser Leu Glu Pro Glu Asp Phe Ala Val Tyr Tyr Cys Gln His Ser Arg 
                85                  90                  95      


Asp Leu Pro Leu Thr Phe Gly Gly Gly Thr Lys Val Glu Ile Lys 
            100                 105                 110     


<210>  52
<211>  447
<212>  PRT
<213>  ˹УArtificial Sequence

<220>
<223>  鵥 

<400>  52

Gln Val Gln Leu Val Gln Ser Gly Val Glu Val Lys Lys Pro Gly Ala 
1               5                   10                  15      


Ser Val Lys Val Ser Cys Lys Ala Ser Gly Tyr Thr Phe Thr Asn Tyr 
            20                  25                  30          


Tyr Met Tyr Trp Val Arg Gln Ala Pro Gly Gln Gly Leu Glu Trp Met 
        35                  40                  45              


Gly Gly Ile Asn Pro Ser Asn Gly Gly Thr Asn Phe Asn Glu Lys Phe 
    50                  55                  60                  


Lys Asn Arg Val Thr Leu Thr Thr Asp Ser Ser Thr Thr Thr Ala Tyr 
65                  70                  75                  80  


Met Glu Leu Lys Ser Leu Gln Phe Asp Asp Thr Ala Val Tyr Tyr Cys 
                85                  90                  95      


Ala Arg Arg Asp Tyr Arg Phe Asp Met Gly Phe Asp Tyr Trp Gly Gln 
            100                 105                 110         


Gly Thr Thr Val Thr Val Ser Ser Ala Ser Thr Lys Gly Pro Ser Val 
        115                 120                 125             


Phe Pro Leu Ala Pro Cys Ser Arg Ser Thr Ser Glu Ser Thr Ala Ala 
    130                 135                 140                 


Leu Gly Cys Leu Val Lys Asp Tyr Phe Pro Glu Pro Val Thr Val Ser 
145                 150                 155                 160 


Trp Asn Ser Gly Ala Leu Thr Ser Gly Val His Thr Phe Pro Ala Val 
                165                 170                 175     


Leu Gln Ser Ser Gly Leu Tyr Ser Leu Ser Ser Val Val Thr Val Pro 
            180                 185                 190         


Ser Ser Ser Leu Gly Thr Lys Thr Tyr Thr Cys Asn Val Asp His Lys 
        195                 200                 205             


Pro Ser Asn Thr Lys Val Asp Lys Arg Val Glu Ser Lys Tyr Gly Pro 
    210                 215                 220                 


Pro Cys Pro Pro Cys Pro Ala Pro Glu Phe Leu Gly Gly Pro Ser Val 
225                 230                 235                 240 


Phe Leu Phe Pro Pro Lys Pro Lys Asp Thr Leu Met Ile Ser Arg Thr 
                245                 250                 255     


Pro Glu Val Thr Cys Val Val Val Asp Val Ser Gln Glu Asp Pro Glu 
            260                 265                 270         


Val Gln Phe Asn Trp Tyr Val Asp Gly Val Glu Val His Asn Ala Lys 
        275                 280                 285             


Thr Lys Pro Arg Glu Glu Gln Phe Asn Ser Thr Tyr Arg Val Val Ser 
    290                 295                 300                 


Val Leu Thr Val Leu His Gln Asp Trp Leu Asn Gly Lys Glu Tyr Lys 
305                 310                 315                 320 


Cys Lys Val Ser Asn Lys Gly Leu Pro Ser Ser Ile Glu Lys Thr Ile 
                325                 330                 335     


Ser Lys Ala Lys Gly Gln Pro Arg Glu Pro Gln Val Tyr Thr Leu Pro 
            340                 345                 350         


Pro Ser Gln Glu Glu Met Thr Lys Asn Gln Val Ser Leu Thr Cys Leu 
        355                 360                 365             


Val Lys Gly Phe Tyr Pro Ser Asp Ile Ala Val Glu Trp Glu Ser Asn 
    370                 375                 380                 


Gly Gln Pro Glu Asn Asn Tyr Lys Thr Thr Pro Pro Val Leu Asp Ser 
385                 390                 395                 400 


Asp Gly Ser Phe Phe Leu Tyr Ser Arg Leu Thr Val Asp Lys Ser Arg 
                405                 410                 415     


Trp Gln Glu Gly Asn Val Phe Ser Cys Ser Val Met His Glu Ala Leu 
            420                 425                 430         


His Asn His Tyr Thr Gln Lys Ser Leu Ser Leu Ser Leu Gly Lys 
        435                 440                 445         


<210>  53
<211>  218
<212>  PRT
<213>  ˹УArtificial Sequence

<220>
<223>  鵥 

<400>  53

Glu Ile Val Leu Thr Gln Ser Pro Ala Thr Leu Ser Leu Ser Pro Gly 
1               5                   10                  15      


Glu Arg Ala Thr Leu Ser Cys Arg Ala Ser Lys Gly Val Ser Thr Ser 
            20                  25                  30          


Gly Tyr Ser Tyr Leu His Trp Tyr Gln Gln Lys Pro Gly Gln Ala Pro 
        35                  40                  45              


Arg Leu Leu Ile Tyr Leu Ala Ser Tyr Leu Glu Ser Gly Val Pro Ala 
    50                  55                  60                  


Arg Phe Ser Gly Ser Gly Ser Gly Thr Asp Phe Thr Leu Thr Ile Ser 
65                  70                  75                  80  


Ser Leu Glu Pro Glu Asp Phe Ala Val Tyr Tyr Cys Gln His Ser Arg 
                85                  90                  95      


Asp Leu Pro Leu Thr Phe Gly Gly Gly Thr Lys Val Glu Ile Lys Arg 
            100                 105                 110         


Thr Val Ala Ala Pro Ser Val Phe Ile Phe Pro Pro Ser Asp Glu Gln 
        115                 120                 125             


Leu Lys Ser Gly Thr Ala Ser Val Val Cys Leu Leu Asn Asn Phe Tyr 
    130                 135                 140                 


Pro Arg Glu Ala Lys Val Gln Trp Lys Val Asp Asn Ala Leu Gln Ser 
145                 150                 155                 160 


Gly Asn Ser Gln Glu Ser Val Thr Glu Gln Asp Ser Lys Asp Ser Thr 
                165                 170                 175     


Tyr Ser Leu Ser Ser Thr Leu Thr Leu Ser Lys Ala Asp Tyr Glu Lys 
            180                 185                 190         


His Lys Val Tyr Ala Cys Glu Val Thr His Gln Gly Leu Ser Ser Pro 
        195                 200                 205             


Val Thr Lys Ser Phe Asn Arg Gly Glu Cys 
    210                 215             


<210>  54
<211>  118
<212>  PRT
<213>  ˹УArtificial Sequence

<220>
<223>  鵥 VH

<400>  54

Glu Val Gln Leu Val Glu Ser Gly Gly Gly Leu Val Gln Pro Gly Gly 
1               5                   10                  15      


Ser Leu Arg Leu Ser Cys Ala Ala Ser Gly Phe Thr Phe Ser Asp Ser 
            20                  25                  30          


Trp Ile His Trp Val Arg Gln Ala Pro Gly Lys Gly Leu Glu Trp Val 
        35                  40                  45              


Ala Trp Ile Ser Pro Tyr Gly Gly Ser Thr Tyr Tyr Ala Asp Ser Val 
    50                  55                  60                  


Lys Gly Arg Phe Thr Ile Ser Ala Asp Thr Ser Lys Asn Thr Ala Tyr 
65                  70                  75                  80  


Leu Gln Met Asn Ser Leu Arg Ala Glu Asp Thr Ala Val Tyr Tyr Cys 
                85                  90                  95      


Ala Arg Arg His Trp Pro Gly Gly Phe Asp Tyr Trp Gly Gln Gly Thr 
            100                 105                 110         


Leu Val Thr Val Ser Ser 
        115             


<210>  55
<211>  107
<212>  PRT
<213>  ˹УArtificial Sequence

<220>
<223>  鵥 VL

<400>  55

Asp Ile Gln Met Thr Gln Ser Pro Ser Ser Leu Ser Ala Ser Val Gly 
1               5                   10                  15      


Asp Arg Val Thr Ile Thr Cys Arg Ala Ser Gln Asp Val Ser Thr Ala 
            20                  25                  30          


Val Ala Trp Tyr Gln Gln Lys Pro Gly Lys Ala Pro Lys Leu Leu Ile 
        35                  40                  45              


Tyr Ser Ala Ser Phe Leu Tyr Ser Gly Val Pro Ser Arg Phe Ser Gly 
    50                  55                  60                  


Ser Gly Ser Gly Thr Asp Phe Thr Leu Thr Ile Ser Ser Leu Gln Pro 
65                  70                  75                  80  


Glu Asp Phe Ala Thr Tyr Tyr Cys Gln Gln Tyr Leu Tyr His Pro Ala 
                85                  90                  95      


Thr Phe Gly Gln Gly Thr Lys Val Glu Ile Lys 
            100                 105         


<210>  56
<211>  448
<212>  PRT
<213>  ˹УArtificial Sequence

<220>
<223>  鵥

<400>  56

Glu Val Gln Leu Val Glu Ser Gly Gly Gly Leu Val Gln Pro Gly Gly 
1               5                   10                  15      


Ser Leu Arg Leu Ser Cys Ala Ala Ser Gly Phe Thr Phe Ser Asp Ser 
            20                  25                  30          


Trp Ile His Trp Val Arg Gln Ala Pro Gly Lys Gly Leu Glu Trp Val 
        35                  40                  45              


Ala Trp Ile Ser Pro Tyr Gly Gly Ser Thr Tyr Tyr Ala Asp Ser Val 
    50                  55                  60                  


Lys Gly Arg Phe Thr Ile Ser Ala Asp Thr Ser Lys Asn Thr Ala Tyr 
65                  70                  75                  80  


Leu Gln Met Asn Ser Leu Arg Ala Glu Asp Thr Ala Val Tyr Tyr Cys 
                85                  90                  95      


Ala Arg Arg His Trp Pro Gly Gly Phe Asp Tyr Trp Gly Gln Gly Thr 
            100                 105                 110         


Leu Val Thr Val Ser Ser Ala Ser Thr Lys Gly Pro Ser Val Phe Pro 
        115                 120                 125             


Leu Ala Pro Ser Ser Lys Ser Thr Ser Gly Gly Thr Ala Ala Leu Gly 
    130                 135                 140                 


Cys Leu Val Lys Asp Tyr Phe Pro Glu Pro Val Thr Val Ser Trp Asn 
145                 150                 155                 160 


Ser Gly Ala Leu Thr Ser Gly Val His Thr Phe Pro Ala Val Leu Gln 
                165                 170                 175     


Ser Ser Gly Leu Tyr Ser Leu Ser Ser Val Val Thr Val Pro Ser Ser 
            180                 185                 190         


Ser Leu Gly Thr Gln Thr Tyr Ile Cys Asn Val Asn His Lys Pro Ser 
        195                 200                 205             


Asn Thr Lys Val Asp Lys Lys Val Glu Pro Lys Ser Cys Asp Lys Thr 
    210                 215                 220                 


His Thr Cys Pro Pro Cys Pro Ala Pro Glu Leu Leu Gly Gly Pro Ser 
225                 230                 235                 240 


Val Phe Leu Phe Pro Pro Lys Pro Lys Asp Thr Leu Met Ile Ser Arg 
                245                 250                 255     


Thr Pro Glu Val Thr Cys Val Val Val Asp Val Ser His Glu Asp Pro 
            260                 265                 270         


Glu Val Lys Phe Asn Trp Tyr Val Asp Gly Val Glu Val His Asn Ala 
        275                 280                 285             


Lys Thr Lys Pro Arg Glu Glu Gln Tyr Ala Ser Thr Tyr Arg Val Val 
    290                 295                 300                 


Ser Val Leu Thr Val Leu His Gln Asp Trp Leu Asn Gly Lys Glu Tyr 
305                 310                 315                 320 


Lys Cys Lys Val Ser Asn Lys Ala Leu Pro Ala Pro Ile Glu Lys Thr 
                325                 330                 335     


Ile Ser Lys Ala Lys Gly Gln Pro Arg Glu Pro Gln Val Tyr Thr Leu 
            340                 345                 350         


Pro Pro Ser Arg Glu Glu Met Thr Lys Asn Gln Val Ser Leu Thr Cys 
        355                 360                 365             


Leu Val Lys Gly Phe Tyr Pro Ser Asp Ile Ala Val Glu Trp Glu Ser 
    370                 375                 380                 


Asn Gly Gln Pro Glu Asn Asn Tyr Lys Thr Thr Pro Pro Val Leu Asp 
385                 390                 395                 400 


Ser Asp Gly Ser Phe Phe Leu Tyr Ser Lys Leu Thr Val Asp Lys Ser 
                405                 410                 415     


Arg Trp Gln Gln Gly Asn Val Phe Ser Cys Ser Val Met His Glu Ala 
            420                 425                 430         


Leu His Asn His Tyr Thr Gln Lys Ser Leu Ser Leu Ser Pro Gly Lys 
        435                 440                 445             


<210>  57
<211>  214
<212>  PRT
<213>  ˹УArtificial Sequence

<220>
<223>  鵥

<400>  57

Asp Ile Gln Met Thr Gln Ser Pro Ser Ser Leu Ser Ala Ser Val Gly 
1               5                   10                  15      


Asp Arg Val Thr Ile Thr Cys Arg Ala Ser Gln Asp Val Ser Thr Ala 
            20                  25                  30          


Val Ala Trp Tyr Gln Gln Lys Pro Gly Lys Ala Pro Lys Leu Leu Ile 
        35                  40                  45              


Tyr Ser Ala Ser Phe Leu Tyr Ser Gly Val Pro Ser Arg Phe Ser Gly 
    50                  55                  60                  


Ser Gly Ser Gly Thr Asp Phe Thr Leu Thr Ile Ser Ser Leu Gln Pro 
65                  70                  75                  80  


Glu Asp Phe Ala Thr Tyr Tyr Cys Gln Gln Tyr Leu Tyr His Pro Ala 
                85                  90                  95      


Thr Phe Gly Gln Gly Thr Lys Val Glu Ile Lys Arg Thr Val Ala Ala 
            100                 105                 110         


Pro Ser Val Phe Ile Phe Pro Pro Ser Asp Glu Gln Leu Lys Ser Gly 
        115                 120                 125             


Thr Ala Ser Val Val Cys Leu Leu Asn Asn Phe Tyr Pro Arg Glu Ala 
    130                 135                 140                 


Lys Val Gln Trp Lys Val Asp Asn Ala Leu Gln Ser Gly Asn Ser Gln 
145                 150                 155                 160 


Glu Ser Val Thr Glu Gln Asp Ser Lys Asp Ser Thr Tyr Ser Leu Ser 
                165                 170                 175     


Ser Thr Leu Thr Leu Ser Lys Ala Asp Tyr Glu Lys His Lys Val Tyr 
            180                 185                 190         


Ala Cys Glu Val Thr His Gln Gly Leu Ser Ser Pro Val Thr Lys Ser 
        195                 200                 205             


Phe Asn Arg Gly Glu Cys 
    210                 


<210>  58
<211>  10
<212>  PRT
<213>  ˹УArtificial Sequence

<220>
<223>  鵥 HCDR1

<400>  58

Gly Phe Thr Phe Ser Asp Ser Trp Ile His 
1               5                   10  


<210>  59
<211>  18
<212>  PRT
<213>  ˹УArtificial Sequence

<220>
<223>  鵥 HCDR2

<400>  59

Ala Trp Ile Ser Pro Tyr Gly Gly Ser Thr Tyr Tyr Ala Asp Ser Val 
1               5                   10                  15      


Lys Gly 
        


<210>  60
<211>  9
<212>  PRT
<213>  ˹УArtificial Sequence

<220>
<223>  鵥  HCDR3

<400>  60

Arg His Trp Pro Gly Gly Phe Asp Tyr 
1               5                   


<210>  61
<211>  11
<212>  PRT
<213>  ˹УArtificial Sequence

<220>
<223>  鵥  LCDR1

<400>  61

Arg Ala Ser Gln Asp Val Ser Thr Ala Val Ala 
1               5                   10      


<210>  62
<211>  7
<212>  PRT
<213>  ˹УArtificial Sequence

<220>
<223>  鵥  LCDR2

<400>  62

Ser Ala Ser Phe Leu Tyr Ser 
1               5           


<210>  63
<211>  9
<212>  PRT
<213>  ˹УArtificial Sequence

<220>
<223>  鵥  LCDR3

<400>  63

Gln Gln Tyr Leu Tyr His Pro Ala Thr 
1               5                   


<210>  64
<211>  30
<212>  PRT
<213>  ˹УArtificial Sequence

<220>
<223>  H-FR1ͨʽ
<220>
<221>  misc_feature
<222>  (2)..(2)
<223>  Xaa = IleVal

<220>
<221>  misc_feature
<222>  (9)..(9)
<223>  Xaa = ProSer

<220>
<221>  misc_feature
<222>  (16)..(16)
<223>  Xaa = AlaGlu

<220>
<221>  misc_feature
<222>  (17)..(17)
<223>  Xaa = SerThr

<220>
<221>  misc_feature
<222>  (20)..(20)
<223>  Xaa = IleVal

<400>  64

Gln Xaa Gln Leu Val Gln Ser Gly Xaa Glu Leu Lys Lys Pro Gly Xaa 
1               5                   10                  15      


Xaa Val Lys Xaa Ser Cys Lys Ala Ser Gly Tyr Thr Phe Thr 
            20                  25                  30  


<210>  65
<211>  14
<212>  PRT
<213>  ˹УArtificial Sequence

<220>
<223>  H-FR2ͨʽ
<220>
<221>  misc_feature
<222>  (3)..(3)
<223>  Xaa = LysArg

<220>
<221>  misc_feature
<222>  (8)..(8)
<223>  Xaa = LysGln

<220>
<221>  misc_feature
<222>  (11)..(11)
<223>  Xaa = GluLys

<400>  65

Trp Val Xaa Gln Ala Pro Gly Xaa Gly Leu Xaa Trp Met Gly 
1               5                   10                  


<210>  66
<211>  32
<212>  PRT
<213>  ˹УArtificial Sequence

<220>
<223> H-FR3ͨʽ

<220>
<221>  misc_feature
<222>  (3)..(3)
<223>  Xaa = AlaVal

<220>
<221>  misc_feature
<222>  (7)..(7)
<223>  Xaa = AspGlu

<220>
<221>  misc_feature
<222>  (10)..(10)
<223>  Xaa = AlaVal

<220>
<221>  misc_feature
<222>  (12)..(12)
<223>  Xaa = MetThr

<220>
<221>  misc_feature
<222>  (18)..(18)
<223>  Xaa = AsnSer

<220>
<221>  misc_feature
<222>  (19)..(19)
<223>  Xaa = AsnSer

<220>
<221>  misc_feature
<222>  (22)..(22)
<223>  Xaa = AlaAsn

<220>
<221>  misc_feature
<222>  (27)..(27)
<223>  Xaa = ThrVal

<220>
<221>  misc_feature
<222>  (29)..(29)
<223>  Xaa = PheTyr

<400>  66

Arg Phe Xaa Phe Ser Leu Xaa Thr Ser Xaa Ser Xaa Ala Tyr Leu Gln 
1               5                   10                  15      


Ile Xaa Xaa Leu Lys Xaa Glu Asp Thr Ala Xaa Tyr Xaa Cys Ala Arg 
            20                  25                  30          


<210>  67
<211>  11
<212>  PRT
<213>  ˹УArtificial Sequence

<220>
<223>  H-FR4ͨʽ

<220>
<221>  misc_feature
<222>  (6)..(6)
<223>  Xaa = LeuThr

<220>
<221>  misc_feature
<222>  (7)..(7)
<223>  Xaa = LeuVal

<400>  67

Trp Gly Gln Gly Thr Xaa Xaa Thr Val Ser Ser 
1               5                   10      


<210>  68
<211>  23
<212>  PRT
<213>  ˹УArtificial Sequence

<220>
<223>  L-FR1ͨʽ

<220>
<221>  misc_feature
<222>  (5)..(5)
<223>  Xaa = AsnThr

<220>
<221>  misc_feature
<222>  (15)..(15)
<223>  Xaa = LeuVal

<220>
<221>  misc_feature
<222>  (18)..(18)
<223>  Xaa = ArgThr

<220>
<221>  misc_feature
<222>  (19)..(19)
<223>  Xaa = IleVal

<400>  68

Asp Ile Gln Met Xaa Gln Ser Pro Ser Ser Leu Ser Ala Ser Xaa Gly 
1               5                   10                  15      


Asp Xaa Xaa Thr Ile Thr Cys 
            20              


<210>  69
<211>  15
<212>  PRT
<213>  ˹УArtificial Sequence

<220>
<223>  L-FR2ͨʽ

<220>
<221>  misc_feature
<222>  (8)..(8)
<223>  Xaa = LysAsn

<220>
<221>  misc_feature
<222>  (9)..(9)
<223>  Xaa = AlaIle

<400>  69

Trp Tyr Gln Gln Lys Pro Gly Xaa Xaa Pro Lys Leu Leu Ile Tyr 
1               5                   10                  15  


<210>  70
<211>  32
<212>  PRT
<213>  ˹УArtificial Sequence

<220>
<223> L-FR3ͨʽ
<220>
<221>  misc_feature
<222>  (12)..(12)
<223>  Xaa = GlyArg

<220>
<221>  misc_feature
<222>  (14)..(14)
<223>  Xaa = AspGly

<220>
<221>  misc_feature
<222>  (27)..(27)
<223>  Xaa = PheIle

<400>  70

Gly Val Pro Ser Arg Phe Ser Gly Ser Gly Ser Xaa Thr Xaa Phe Thr 
1               5                   10                  15      


Leu Thr Ile Ser Ser Leu Gln Pro Glu Asp Xaa Ala Thr Tyr Tyr Cys 
            20                  25                  30          


<210>  71
<211>  10
<212>  PRT
<213>  ˹УArtificial Sequence

<220>
<223>  L-FR4ͨʽ

<220>
<221>  misc_feature
<222>  (7)..(7)
<223>  Xaa = LeuVal

<400>  71

Phe Gly Gly Gly Thr Lys Xaa Glu Ile Lys 
1               5                   10  


<210>  72
<211>  120
<212>  PRT
<213>  ˹УArtificial Sequence

<220>
<223>  VHͨʽ

<220>
<221>  misc_feature
<222>  (2)..(2)
<223>  Xaa = IleVal

<220>
<221>  misc_feature
<222>  (9)..(9)
<223>  Xaa = ProSer

<220>
<221>  misc_feature
<222>  (16)..(16)
<223>  Xaa = AlaGlu

<220>
<221>  misc_feature
<222>  (17)..(17)
<223>  Xaa = SerThr

<220>
<221>  misc_feature
<222>  (20)..(20)
<223>  Xaa = IleVal

<220>
<221>  misc_feature
<222>  (38)..(38)
<223>  Xaa = LysArg

<220>
<221>  misc_feature
<222>  (43)..(43)
<223>  Xaa = LysGln

<220>
<221>  misc_feature
<222>  (46)..(46)
<223>  Xaa = GluLys

<220>
<221>  misc_feature
<222>  (69)..(69)
<223>  Xaa = AlaVal

<220>
<221>  misc_feature
<222>  (73)..(73)
<223>  Xaa = AspGlu

<220>
<221>  misc_feature
<222>  (76)..(76)
<223>  Xaa = AlaVal

<220>
<221>  misc_feature
<222>  (78)..(78)
<223>  Xaa = MetThr

<220>
<221>  misc_feature
<222>  (84)..(84)
<223>  Xaa = AsnSer

<220>
<221>  misc_feature
<222>  (85)..(85)
<223>  Xaa = AsnSer

<220>
<221>  misc_feature
<222>  (88)..(88)
<223>  Xaa = AlaAsn

<220>
<221>  misc_feature
<222>  (93)..(93)
<223>  Xaa = ThrVal

<220>
<221>  misc_feature
<222>  (95)..(95)
<223>  Xaa = PheTyr

<220>
<221>  misc_feature
<222>  (115)..(115)
<223>  Xaa = LeuThr

<220>
<221>  misc_feature
<222>  (116)..(116)
<223>  Xaa = LeuVal

<400>  72

Gln Xaa Gln Leu Val Gln Ser Gly Xaa Glu Leu Lys Lys Pro Gly Xaa 
1               5                   10                  15      


Xaa Val Lys Xaa Ser Cys Lys Ala Ser Gly Tyr Thr Phe Thr Thr Tyr 
            20                  25                  30          


Glu Met Ser Trp Val Xaa Gln Ala Pro Gly Xaa Gly Leu Xaa Trp Met 
        35                  40                  45              


Gly Trp Ile Asn Thr Tyr Ser Gly Val Pro Thr Tyr Ala Asp Asp Phe 
    50                  55                  60                  


Lys Gly Arg Phe Xaa Phe Ser Leu Xaa Thr Ser Xaa Ser Xaa Ala Tyr 
65                  70                  75                  80  


Leu Gln Ile Xaa Xaa Leu Lys Xaa Glu Asp Thr Ala Xaa Tyr Xaa Cys 
                85                  90                  95      


Ala Arg Glu Gly Val Tyr Asp Tyr Pro Tyr Phe Asp Ser Trp Gly Gln 
            100                 105                 110         


Gly Thr Xaa Xaa Thr Val Ser Ser 
        115                 120 


<210>  73
<211>  107
<212>  PRT
<213>  ˹УArtificial Sequence

<220>
<223>  VLͨʽ

<220>
<221>  misc_feature
<222>  (5)..(5)
<223>  Xaa = AsnThr

<220>
<221>  misc_feature
<222>  (15)..(15)
<223>  Xaa = LeuVal

<220>
<221>  misc_feature
<222>  (18)..(18)
<223>  Xaa = ArgThr

<220>
<221>  misc_feature
<222>  (19)..(19)
<223>  Xaa = IleVal

<220>
<221>  misc_feature
<222>  (42)..(42)
<223>  Xaa = LysAsn

<220>
<221>  misc_feature
<222>  (43)..(43)
<223>  Xaa = AlaIle

<220>
<221>  misc_feature
<222>  (68)..(68)
<223>  Xaa = GlyArg

<220>
<221>  misc_feature
<222>  (70)..(70)
<223>  Xaa = AspGly

<220>
<221>  misc_feature
<222>  (83)..(83)
<223>  Xaa = PheIle

<220>
<221>  misc_feature
<222>  (104)..(104)
<223>  Xaa = LeuVal

<400>  73

Asp Ile Gln Met Xaa Gln Ser Pro Ser Ser Leu Ser Ala Ser Xaa Gly 
1               5                   10                  15      


Asp Xaa Xaa Thr Ile Thr Cys His Ala Ser Gln Asn Ile Asn Val Trp 
            20                  25                  30          


Leu Ser Trp Tyr Gln Gln Lys Pro Gly Xaa Xaa Pro Lys Leu Leu Ile 
        35                  40                  45              


Tyr Lys Ala Ser Asn Leu His Thr Gly Val Pro Ser Arg Phe Ser Gly 
    50                  55                  60                  


Ser Gly Ser Xaa Thr Xaa Phe Thr Leu Thr Ile Ser Ser Leu Gln Pro 
65                  70                  75                  80  


Glu Asp Xaa Ala Thr Tyr Tyr Cys Gln Gln Gly Gln Ser Ser Pro Leu 
                85                  90                  95      


Thr Phe Gly Gly Gly Thr Lys Xaa Glu Ile Lys 
            100                 105         



