                         SEQUENCE LISTING

<110>  Biocytogen PharmaceuticalsBeijingCo., Ltd.
 
<120>  GENETICALLY MODIFIED NON-HUMAN ANIMAL WITH HUMAN OR CHIMERIC 
       GENES

<130>  1

<150>  CN202110425356.X
<151>  2021-04-20

<150>  CN202210185622.0
<151>  2022-02-28

<160>  53    

<170>  PatentIn version 3.5

<210>  1
<211>  552
<212>  PRT
<213>  Mus musculus

<400>  1

Met Thr Ala Arg Gly Ala Ala Gly Arg Cys Pro Ser Ser Thr Trp Leu 
1               5                   10                  15      


Gly Ser Arg Leu Leu Leu Val Cys Leu Leu Met Ser Arg Ser Ile Ala 
            20                  25                  30          


Lys Glu Val Ser Glu His Cys Ser His Met Ile Gly Asn Gly His Leu 
        35                  40                  45              


Lys Val Leu Gln Gln Leu Ile Asp Ser Gln Met Glu Thr Ser Cys Gln 
    50                  55                  60                  


Ile Ala Phe Glu Phe Val Asp Gln Glu Gln Leu Asp Asp Pro Val Cys 
65                  70                  75                  80  


Tyr Leu Lys Lys Ala Phe Phe Leu Val Gln Asp Ile Ile Asp Glu Thr 
                85                  90                  95      


Met Arg Phe Lys Asp Asn Thr Pro Asn Ala Asn Ala Thr Glu Arg Leu 
            100                 105                 110         


Gln Glu Leu Ser Asn Asn Leu Asn Ser Cys Phe Thr Lys Asp Tyr Glu 
        115                 120                 125             


Glu Gln Asn Lys Ala Cys Val Arg Thr Phe His Glu Thr Pro Leu Gln 
    130                 135                 140                 


Leu Leu Glu Lys Ile Lys Asn Phe Phe Asn Glu Thr Lys Asn Leu Leu 
145                 150                 155                 160 


Glu Lys Asp Trp Asn Ile Phe Thr Lys Asn Cys Asn Asn Ser Phe Ala 
                165                 170                 175     


Lys Cys Ser Ser Arg Asp Val Val Thr Lys Pro Asp Cys Asn Cys Leu 
            180                 185                 190         


Tyr Pro Lys Ala Thr Pro Ser Ser Asp Pro Ala Ser Ala Ser Pro His 
        195                 200                 205             


Gln Pro Pro Ala Pro Ser Met Ala Pro Leu Ala Gly Leu Ala Trp Asp 
    210                 215                 220                 


Asp Ser Gln Arg Thr Glu Gly Ser Ser Leu Leu Pro Ser Glu Leu Pro 
225                 230                 235                 240 


Leu Arg Ile Glu Asp Pro Gly Ser Ala Lys Gln Arg Pro Pro Arg Ser 
                245                 250                 255     


Thr Cys Gln Thr Leu Glu Ser Thr Glu Gln Pro Asn His Gly Asp Arg 
            260                 265                 270         


Leu Thr Glu Asp Ser Gln Pro His Pro Ser Ala Gly Gly Pro Val Pro 
        275                 280                 285             


Gly Val Glu Asp Ile Leu Glu Ser Ser Leu Gly Thr Asn Trp Val Leu 
    290                 295                 300                 


Glu Glu Ala Ser Gly Glu Ala Ser Glu Gly Phe Leu Thr Gln Glu Ala 
305                 310                 315                 320 


Lys Phe Ser Pro Ser Thr Pro Val Gly Gly Ser Ile Gln Ala Glu Thr 
                325                 330                 335     


Asp Arg Pro Arg Ala Leu Ser Ala Ser Pro Phe Pro Lys Ser Thr Glu 
            340                 345                 350         


Asp Gln Lys Pro Val Asp Ile Thr Asp Arg Pro Leu Thr Glu Val Asn 
        355                 360                 365             


Pro Met Arg Pro Ile Gly Gln Thr Gln Asn Asn Thr Pro Glu Lys Thr 
    370                 375                 380                 


Asp Gly Thr Ser Thr Leu Arg Glu Asp His Gln Glu Pro Gly Ser Pro 
385                 390                 395                 400 


His Ile Ala Thr Pro Asn Pro Gln Arg Val Ser Asn Ser Ala Thr Pro 
                405                 410                 415     


Val Ala Gln Leu Leu Leu Pro Lys Ser His Ser Trp Gly Ile Val Leu 
            420                 425                 430         


Pro Leu Gly Glu Leu Glu Gly Lys Arg Ser Thr Arg Asp Arg Arg Ser 
        435                 440                 445             


Pro Ala Glu Leu Glu Gly Gly Ser Ala Ser Glu Gly Ala Ala Arg Pro 
    450                 455                 460                 


Val Ala Arg Phe Asn Ser Ile Pro Leu Thr Asp Thr Gly His Val Glu 
465                 470                 475                 480 


Gln His Glu Gly Ser Ser Asp Pro Gln Ile Pro Glu Ser Val Phe His 
                485                 490                 495     


Leu Leu Val Pro Gly Ile Ile Leu Val Leu Leu Thr Val Gly Gly Leu 
            500                 505                 510         


Leu Phe Tyr Lys Trp Lys Trp Arg Ser His Arg Asp Pro Gln Thr Leu 
        515                 520                 525             


Asp Ser Ser Val Gly Arg Pro Glu Asp Ser Ser Leu Thr Gln Asp Glu 
    530                 535                 540                 


Asp Arg Gln Val Glu Leu Pro Val 
545                 550         


<210>  2
<211>  554
<212>  PRT
<213>  Homo sapiens

<400>  2

Met Thr Ala Pro Gly Ala Ala Gly Arg Cys Pro Pro Thr Thr Trp Leu 
1               5                   10                  15      


Gly Ser Leu Leu Leu Leu Val Cys Leu Leu Ala Ser Arg Ser Ile Thr 
            20                  25                  30          


Glu Glu Val Ser Glu Tyr Cys Ser His Met Ile Gly Ser Gly His Leu 
        35                  40                  45              


Gln Ser Leu Gln Arg Leu Ile Asp Ser Gln Met Glu Thr Ser Cys Gln 
    50                  55                  60                  


Ile Thr Phe Glu Phe Val Asp Gln Glu Gln Leu Lys Asp Pro Val Cys 
65                  70                  75                  80  


Tyr Leu Lys Lys Ala Phe Leu Leu Val Gln Asp Ile Met Glu Asp Thr 
                85                  90                  95      


Met Arg Phe Arg Asp Asn Thr Pro Asn Ala Ile Ala Ile Val Gln Leu 
            100                 105                 110         


Gln Glu Leu Ser Leu Arg Leu Lys Ser Cys Phe Thr Lys Asp Tyr Glu 
        115                 120                 125             


Glu His Asp Lys Ala Cys Val Arg Thr Phe Tyr Glu Thr Pro Leu Gln 
    130                 135                 140                 


Leu Leu Glu Lys Val Lys Asn Val Phe Asn Glu Thr Lys Asn Leu Leu 
145                 150                 155                 160 


Asp Lys Asp Trp Asn Ile Phe Ser Lys Asn Cys Asn Asn Ser Phe Ala 
                165                 170                 175     


Glu Cys Ser Ser Gln Asp Val Val Thr Lys Pro Asp Cys Asn Cys Leu 
            180                 185                 190         


Tyr Pro Lys Ala Ile Pro Ser Ser Asp Pro Ala Ser Val Ser Pro His 
        195                 200                 205             


Gln Pro Leu Ala Pro Ser Met Ala Pro Val Ala Gly Leu Thr Trp Glu 
    210                 215                 220                 


Asp Ser Glu Gly Thr Glu Gly Ser Ser Leu Leu Pro Gly Glu Gln Pro 
225                 230                 235                 240 


Leu His Thr Val Asp Pro Gly Ser Ala Lys Gln Arg Pro Pro Arg Ser 
                245                 250                 255     


Thr Cys Gln Ser Phe Glu Pro Pro Glu Thr Pro Val Val Lys Asp Ser 
            260                 265                 270         


Thr Ile Gly Gly Ser Pro Gln Pro Arg Pro Ser Val Gly Ala Phe Asn 
        275                 280                 285             


Pro Gly Met Glu Asp Ile Leu Asp Ser Ala Met Gly Thr Asn Trp Val 
    290                 295                 300                 


Pro Glu Glu Ala Ser Gly Glu Ala Ser Glu Ile Pro Val Pro Gln Gly 
305                 310                 315                 320 


Thr Glu Leu Ser Pro Ser Arg Pro Gly Gly Gly Ser Met Gln Thr Glu 
                325                 330                 335     


Pro Ala Arg Pro Ser Asn Phe Leu Ser Ala Ser Ser Pro Leu Pro Ala 
            340                 345                 350         


Ser Ala Lys Gly Gln Gln Pro Ala Asp Val Thr Gly Thr Ala Leu Pro 
        355                 360                 365             


Arg Val Gly Pro Val Arg Pro Thr Gly Gln Asp Trp Asn His Thr Pro 
    370                 375                 380                 


Gln Lys Thr Asp His Pro Ser Ala Leu Leu Arg Asp Pro Pro Glu Pro 
385                 390                 395                 400 


Gly Ser Pro Arg Ile Ser Ser Leu Arg Pro Gln Gly Leu Ser Asn Pro 
                405                 410                 415     


Ser Thr Leu Ser Ala Gln Pro Gln Leu Ser Arg Ser His Ser Ser Gly 
            420                 425                 430         


Ser Val Leu Pro Leu Gly Glu Leu Glu Gly Arg Arg Ser Thr Arg Asp 
        435                 440                 445             


Arg Arg Ser Pro Ala Glu Pro Glu Gly Gly Pro Ala Ser Glu Gly Ala 
    450                 455                 460                 


Ala Arg Pro Leu Pro Arg Phe Asn Ser Val Pro Leu Thr Asp Thr Gly 
465                 470                 475                 480 


His Glu Arg Gln Ser Glu Gly Ser Phe Ser Pro Gln Leu Gln Glu Ser 
                485                 490                 495     


Val Phe His Leu Leu Val Pro Ser Val Ile Leu Val Leu Leu Ala Val 
            500                 505                 510         


Gly Gly Leu Leu Phe Tyr Arg Trp Arg Arg Arg Ser His Gln Glu Pro 
        515                 520                 525             


Gln Arg Ala Asp Ser Pro Leu Glu Gln Pro Glu Gly Ser Pro Leu Thr 
    530                 535                 540                 


Gln Asp Asp Arg Gln Val Glu Leu Pro Val 
545                 550                 


<210>  3
<211>  3471
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  5' arm

<400>  3
tcttcagcca ctagcgagca agggagcgag cgaaccaggg cggccaacac gccgtgccgg       60

gacccagctg cccgtatgac cgcgcggggc gccgcggggc gctgcccttc ttcggtaagc      120

tgcaaccgtg gcgcgcgggg cccgggccgg gctggggcag gagctctgca gcaagcagca      180

ggcggctctg cggggccact tggagcggac agccccttct cgccagctgc ccaggcttct      240

cggccctggg ttctggcttc cttactgctt ctaagctacg gctgaggccc gcggtatttc      300

aatagctgct cctggggctg cagcgctttg cgaggtaaag agaaggctgc tcatcccatt      360

gcacggagga gaacactgag ctacccacag gctggagaga gagatggggg tctggggggg      420

gggggtatcg cagggattgg cacaggccca atgtctgcca gaatggtcaa ccaggtctcc      480

aggttccgag tgacacaaga tccgagtgtg gcatcatccc cagtagatat ctttctttgg      540

ttgttgcaca tgttttaggc cccagttggg agtgggcctt cagggtaggg aaaattcagg      600

ctcactcagc tttacaccag gacctgtgct gagcaacctg ttggcagaga gagagagaga      660

gagagagaga gagagagaga gatgggcatg ctgctacttg ttcaatggat gtgtaggaac      720

tattagggac ttgggtggct ctttgagggg agctggaccc gaatcttttc ttgaagaaaa      780

tgagatgggg ctattctaga ctctgcggct gactgaggaa agaaagtgca aggagagttc      840

agagctgcag ctgataatgg gctgctcaga agctgtctcc agtaatggca gcagatgata      900

gcatggctct tacagagtga aggatggtac tttcaatcca cagcaagtgg gtttgcttca      960

gaagagaatg agagggaaaa cctggagggt aggaaccgaa cttgtgatgg gcagcgcgtt     1020

gcaggtgtct gggaggagag aaaagtagaa cagcagagag aggggctcag tgagaggcag     1080

aaggtggggt taggaggagg ggaagggagg aagttatccc acatgcaaca agcataaaga     1140

gagaagaggg aagaaaagaa agactacaag gagacataag aggaaagaga ggaggccgag     1200

gttcagccag gcagtcaggc cgggtctctg tctgcagact gtactgattg gaaaatggaa     1260

catgatgtct tgaagtgctc agagactgcc gcagtttcca ggctgctctc atagtcagag     1320

gctgaggcag tgggtgggag gaagaagcaa gccaggaaga gcctgtccag ccagatgcag     1380

gctagagtat taacccttgg gtgtccatct gtatccctgt ctatggcagc attggggtta     1440

cagagccaga tccaggagtg gctggtcatc tttgaagcca gcagctgtgc attatttctg     1500

tgcatgcttg aaatgccacc aaaagccagg tagccctgaa gtaatgtctt tatcttgcta     1560

tctccaaaca tcaatggctt gaaattcctg ggttgagata tttctgaaca tctccattcc     1620

cgggtccttt ccttcatacc atacacacat ggactgacag gctgagtgat accagcctgg     1680

gccagagtca tcttctgcag tcatttcctt taacaggttc tgagactggg gttcaggaga     1740

cccgggctgc cactcccact caggactaac tttccaattg cccaaccatg cccaatgcag     1800

tttatcaacc catagctggc tgcaccctct cccccacctc tttctccctg tctctctgtg     1860

tctgtcactc tgtgtctctg actgtctgtc tctgactgtc tgtctctgac tctctgtctc     1920

tctctctctc taaggtcagg caaggaacct aacaggtcct gtgcgtaatg gcattaggca     1980

accctgtgcc ttaacaccca tcagcatctt ccacccttta aggcctcact cttccctccg     2040

catggcccag ccaaagctgc ctttcctccc tggtactcac tggcaaggct ttgggctttt     2100

agatgtaacc cagtgttgtt atggactgtt tcatagcctc cctgtgtttt tccaatgcgc     2160

tcctatttgc aacatttgtc tcatcatctg gactattggg gcagagccag atccaagaag     2220

gtgccagtca tcactccacc ctgccagcat ttccctgaat tgggggatat cagcagccag     2280

aatgctcaga atggcagcat caggccaggg aaagaaagcc caagagtccc tctgccccag     2340

gctggcatct cccgggatac cctattggag cccgaaggga tggaaggatt ttagagtaga     2400

ggaggaggaa ggaagaaagg agaaaggaag gacccagtca ggtgtcagga gccagaccta     2460

ggactctagg gatgagcagc tgcagggcca ggtgggtgct gacggaaagg agagaacttt     2520

cttgctgtgg caagagtttg ctgactagat gaagggcctg atgggtctca gataaacaga     2580

tgccagcagg gaaacacagc attgtccttg attagtcagc tggactcctc ttgaaatgca     2640

agtccaaggc tctaggaggt ctcccactgg agctgagttc ccagtgttgc atcctggtat     2700

tttcccctgt agaaccagac ctgtgtaacc aggtgggaag gaaggaatga aggaaggaag     2760

gaaggtgcca ggggtaatga gtgtttctgg cttgcaatct gaaagctagt gactgaccac     2820

aagtttgaag gcagcttaca aggtatctat ttgtctcagt gttaaaagtt aaaaggatag     2880

aaaatcttac ccttgagtct ctcagtcact aaaacttata ctggttggca caccaccagt     2940

attatcatta gacattctct gtaagatgga aaggtggctc atcatttaaa aacacttgtt     3000

gctcttgcag tggatccagg ttcaaatccc agaatctaga tgatggttca caaccattca     3060

tacctccagg tccaggagat tccaagaagg aagcacatag agtgtgtgca tgcaagcagg     3120

caaaatattc ataaacacaa aacaaaaaca gtaagccttt taaaattgtc ttttaaagta     3180

ctctgtattg ttgagctgct ctgggttaac ctcagaagag ttcttggaga agatggcatt     3240

tgggctatta ccaagggaag agtgaggtgg tgccctggct gataagaatc taatggtgct     3300

gcagcatggg aatggggcgt tgtttctttg cccttagtgg gacatggggg tagctaggga     3360

gaggaagtgc tggaaagaca tgactccctt ctgttataga catggctggg ctcccggctg     3420

ctgctggtct gtctcctcat gagcaggagt attgccaagg aggtgtcaga a              3471


<210>  4
<211>  3642
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  3' arm

<400>  4
tgtgccttat ctggtcctac tcccaagcca aggttattgc tgcctccctg atttaggatc       60

attgtgccat agaaatttag tcttaggaga gctgtcgaga ggtcatttgg cccagtgtcc      120

cagcctaaaa gggttactct gcatccccca cagggagtca gccagcttcc tgcacacaca      180

cacacacact cccagttcca ggcaagttct ctgcatgcca gtctgctcaa ctggggtcac      240

aacattgggg tcacaacaca caacactggg ggagttcctt ccttatgtag gcaaagctgc      300

cttcctttct tcccttccca gaccaatcct ctctcatctt ctcatgaggc ctgatattta      360

aagtcagcta ttcatgtcac cttttaaaat tctctgtgtt aagtgtggcc aagcccctca      420

aacattcctt atatgatatg gttttcagac ccctcaccat cctggacaca ctcgtttgtc      480

aatgtccctc tgaaaatgtg gcgcccagcc ctggacacag tactccagat gttgtctgac      540

cagctcagag tacagtggga cggttgtctt ccttgatctg gacagtactc ttctactcgt      600

gcagattaag atcacattag ttttaacagc tgcatcatat attgtcatat gttgagcttg      660

tagtctatta aaaaccccag ttctatttcc tgtgaacctt tgtccagtag accgtcgcca      720

tcccatactc ccatacttgg acacaaccgt tttagccaaa gtgtagctgg tgctcacctt      780

tgttaaaact ccttgttgtt ttctgcccat cccctgagcc tactgaaagt gttttagttc      840

ctaatttggt cactttataa ctcctggttg ggtcccctgc acattaatgc gtgtcttttg      900

ttgtccttgc ccacgctatt ggtggagatg tgacctgtat tcttcctcta cacccaccca      960

caccagccta tccagaagcc ttcccttcct aaaatattcc acatccctct ggttgatctt     1020

ttaattcatt ctgctctgtt gtatatggct gatgctatat taatccacat acatttggat     1080

gttgttttat gtattttaaa tcatatttta tgtatatatg taaattttga actactaaga     1140

agattgtaag cccctagagg gcagggacta tcttcctttt tatttttttt ccccttcact     1200

tcattaattc tagtacagac agtgccccct ctatccttgt caaaaactta gtaaatggtg     1260

gtagctgttt tcaggtctga atcaccaact aaccccggcc agatttctct aactgaccag     1320

ccttctggct gaccaattaa ctagccaact aatcaactca tcttaccagc tagttggcta     1380

actgactact tggccaacta gctggtaact acttaactga ctagttcttg attgatgagc     1440

tgattggcta actagctggc agagtgctta gttgatttgc tgactgactg gatggcaaac     1500

tagctgtgtg atcggttgaa gtttccagtt ataccccttg ccacatgtaa gcaaactgtc     1560

ccatgtgtag gatgatgtgt ctaagcccct ttcccaaagg aaatatcaca gatgctcaga     1620

gagccaggga gatttatttg aattaaagca agcagcaacc catatctaga atcccgggga     1680

cccactcagc agtaatgtgg gtggagacgg gtgaaatgaa ttagctggct cactggaaca     1740

gctacaagga cacagagtcc ctctgacctg aatcagagag caaaggttgc tggggatttg     1800

ggggctcagt gctgtgtcac cttaccaagg gctaccaggg ttcttcctcc ctgccacctg     1860

tatgaccttg tcctcggccc tggtttctct gtacccagtt gtccttccca tgcctcctaa     1920

ctctcagacc tgcccaagat tttacgttcc tcacctaagg atttcaagat ttcactcagt     1980

cagcgcagat ctaacctgat ccccattcca ggctcaagga gcctatggga actgaatgtc     2040

tgtgtcctga ttgaccaata ctctgacaag gagatgagtg gggcacacag aagtggggac     2100

taagaaaagg tcaccaagtt gtagaaaact caggccctcg gccccaggaa actgggagtt     2160

gggttagagg ctaaggtcat gccctctggg gccttcttcc cgatgggccc tgccagagcc     2220

tgtggcctgg ttgtaccagt atggctcatg cccagtttat agtttcttct tgtttcctat     2280

ccaaagcatg ggaataggct ggtggccaaa ggctgtaggt ctcattttct ttcataccca     2340

tcacaggctt gaccagtggg gctatggaca ttactgggga ggcgccatac agggtccaaa     2400

gtcaaactgt tggctgaagt ccaggggatt tctgctatgg aacaaagagt tctgaggata     2460

ctggacaagg ggacaaagat gggggtgggg tggggagagg gcagggccct ggctcccatg     2520

gatgacaaga ggcaagtccc tcatcccatc tgggaggagg ctaggctgct tggggtgagc     2580

atgcctgttg acagggcaag ccctcccttt tcctggcatt gtctctaccc tctgcccctc     2640

aagcctgagt tctttctatt caaatgcctt tgcccaagtg tcttctgtgc agataccctc     2700

taagggatgg tatgagagtt ggcagagatc accttaggtc attggtctaa gactactgag     2760

atggccttac ctgagaacta gcctagtagg ggcattcaag agcttgttcc ctgctcccat     2820

ctgctagagc aatagccctc tctctctctt ggcctcgacc tcctccagtc ttagtccctc     2880

attttgtggt cactactccc ccaggaggag aggtaggagg tgaggccagg ctatccaaag     2940

gcttggactg ctgccaggca aagctgcctg gtctctctgt ggtgtctggg gtcgcctaga     3000

gggccaggaa aatgaccaga ggaagtcttg ccttaagtca gccaacaacc cacaggaatg     3060

tcacacctcc cccaactatg tccttagcga ccctccccca cactcccctg ctgaccagcc     3120

ttcttccctt ctttccccta cagctgggca cacaggacta tctctttatg gaaggagaca     3180

tatgggaaca tccaccacta ccctctccta ccatcttcct gggaatgtgg cctaccacta     3240

ccagagctcc tgcctaccaa gactggatga aagaagcagc tttgatgggg tctttccatc     3300

ctcaccctta gactctcaac caaagagaaa gggctggagg atgcccccca catactgcca     3360

ctatttattg tgggccctgg aggctccctg cattggagga agggcagctc agcagctcag     3420

gaccctttcc cttaggggct gcttcctccc ctcaaaacca gaacctggca agggactcac     3480

tagcctggat ggcccatggg agaccaggac agatgagaag gagcagaaga gccctgtgcc     3540

cagaagaccc aactggtgcc aaggaatccc agcatggaca ggcagggacc tgtttcccaa     3600

gaagagagcc tgatattcaa agggtgggac agcatctgcc cg                        3642


<210>  5
<211>  10859
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  nucleotide sequence of 109914331-109925189 of NCBI accession 
       number NC_000001.11

<400>  5
tactgtagcc acatgattgg gagtggacac ctgcagtctc tgcagcggct ggtgagtgtg       60

tggccatgct gtattctacc ttctccccac tggggaaatg aaggcaggag ccagggagca      120

ggtcaaagag agcagttgca ggcaggaaaa tagggcagtg cgggacattg cttgtggttc      180

ccactagctc caccagtgat acccttcact aaccttccca aagttaggac ctctggtctc      240

cccagctcga agccctctct gactgccctg caggcagtgg atgctgtggg cttccagctg      300

cttgcctggg ttagtgattg cccaggaaca tcaaccactg attctgaaaa ggcttctgag      360

gtctgctgtc cctcagtggg atgcctcctc tgggaagcta gcccaggcgg cctgctgtgt      420

ccagatgttg catctagctc ctggactctc atatgtggcg ccagtctggc atcagagccc      480

cacccagatt tggaggggaa gcgcttgcct aactcccagc cttccacact cacttccctg      540

gctcttgccc ataccctgag gctgggatgg cctgctcatc tgggccatga aggagcctgt      600

atctcattct aatcagaccc atacgtggtc cagccaggca gaatcaggtt gctgtcatgg      660

ctgctgtcct gctcagtggg aatttaccat tcctctggcc agccaggcag ggtggggcat      720

cactggctaa cgccagctcc agggccctga gcttggggcc tgtgggctgt gccttccgcc      780

tctcttgccc cagcactact tctcctgtat gtagttgctg tagcaatcca aggtagacca      840

agagccccag cattctctga ggcttaaaat ccagaactgc tgctctgggg ctaaagaggg      900

ctttaagggc atccagctcc aacccctaca ggtgttcaat ccccagagct tgtccagcct      960

ctgcttgaat tcctaccatg acagggtgct cactgcctcc agggaagatt atatcctata     1020

ttcttctata gacatctctt ccttaaaaca aatgggcatt tgtcagattt cgtggggtgg     1080

tagaaggaaa gaagagactt cttgttcttc tacagccttc ccctgggcat ctggaaggca     1140

ctgatcttct cctagacttg actctgtctt tccacgtgtg gttggcaggg atgaagttca     1200

aaccccaatc cactcagaag ctaaggtccc cgttttgaag aaggctgaag gctgagttga     1260

gctgtaggtt accctgcaat cgttggcctg ctctctctta cagattgaca gtcagatgga     1320

gacctcgtgc caaattacat ttgagtttgt agaccaggaa cagttggtga gtgatggctt     1380

tttacaaaat ccatgcacca gcctgcatgc aactcccagg gtggggtgtg tgggggagca     1440

tgaaagcggc agaatgccta ctgctggaaa gggtgagagt gtgaggatcc atgggtgctc     1500

aactctgggg tgccaggatc cagggctcaa gtcccctgcc attcccttct cctggcctga     1560

tacataacaa gcgctcacta ggtaccaagc actttgctaa tgtagttctg acagtaccac     1620

tatgtggtac acaaatacag tttattatcc acagagaggt gaaaggagca tagctagtag     1680

gtgctagagg cctgatttga atccaggaag gttggctgta gggcttgagg caaatcaata     1740

cttcttccag gtcacaagct ttgcttaagg atgtcacttc tcttcaccag gccaaccagc     1800

aggcaggtag gcagtccagc ccttcctgga cttgccccac acccaaccag ccaccaagtg     1860

ctgctggttc tgcctctcag catctctggg ttctgtctcc tccatcccca ccttcacccc     1920

tcaatcagtt gcttggacaa tttcaagagc ctcctaactg gtgtctccct gctttctagt     1980

tcactcctca tcttaccact gggggaaatt ttctgaaacg ccaacctgct gcctttacct     2040

ccttctccca aaaacatcag ggcccccatc actccagaag aaagccaagg ttgtctagtc     2100

tgggttacac caggtctagc cattctccac cacacaagcc tctataccac ctccccattc     2160

cctgcttctt cctgcctccc atctttgcac aagctctttc caatgactgt catgcctttc     2220

cacctgcccc ccaatcatta ttccacatct attcatcttt atgcctcatg caaaactgcc     2280

ttgataccca gaagttgccc ctgtttctga gcttccacac acctgaccca tatgcacctc     2340

tgttaggact agagatcacc tcatggtcca aagaatagcc tcagtatttt atgcactcac     2400

tcgcttgctc tagcactcat gcctgaacta gcatttgcta ggaacctact ggactagatg     2460

ctgggggtag agagctaaag cagagtgggt cttcaaggca actaccatct ctttagggag     2520

acaaaacaca gaggttattc tttggaccat gagatagtct tcagcacccc tatgtcctgg     2580

aggatttgaa ggggccatat ggtaaaagat atttgtgaaa gcaagacaag aggaagacag     2640

aaagaaaggc aggggaaggt tccctggagc ccaccttccc tatatacatc catcgtgatt     2700

aaagcctcat attccagaaa cccagagaac tctctaatca gaatccacat ttccttcact     2760

ctagcccagt ctccagtggc gctagatccc aaagagagag aaagacaggc aagctgaggg     2820

cggcattctc ctagttgctg gcatggtgtg gtccctcccc tgggggaagg gggagagcaa     2880

gctgcaaccc tccatctgcc tggggttggg ggttcccagg ccacaatggc caggccataa     2940

gctccaggtt cctgtttttc agaaagatcc agtgtgctac cttaagaagg catttctcct     3000

ggtacaagac ataatggagg acaccatgcg cttcagagat aacaccccca atgccatcgc     3060

cattgtgcag ctgcaggaac tctctttgag gctgaagagc tgcttcacca aggattatga     3120

agagcatgac aaggtaggaa gccctgaggc ctggagcact gagtgagggc agagggtggc     3180

tgtggaggcg ccgctctatc cacaggcaca gagtacattc gctcacctcg cctcacgcca     3240

ttgcttgctc actctcattt atttgtcatc ccaccaacct ttaccaggca ggaggcagga     3300

gggatcatgc tgggccctga caatgtcatc atgagcaaca aatacatggt cccaccccat     3360

gcagcttata gtcaagtgag cttggcagct gttaaacaaa ccatgacacc agtaaataga     3420

attacaaact ataaggactg ttcattccaa cagcaagcag ttattgtgtg tctgttgtgt     3480

accagacact gttctagaca ccaggaaaca gctgtgatga aaacagacaa aaatccccac     3540

attcctggaa cttacatttg ggggtgacgg tagtggtggt gagacagtta acaaaatatg     3600

taagtaaaat atacaacatg tagcatggca ataacagcac tggagaagag taaaccaggg     3660

atgagacgac ccgaaggaag tggaggagtg agctgggaac aagaacctga agggctcaag     3720

gagagcaaca gggaactcag acttccatgg agttggggaa gcagagacaa gaaaggcttc     3780

tgagtaagca aatattgatt tgagctccaa agatgagtaa gaattgaaag cagtaaggct     3840

agaagaacat tctggaacag gaaaagctat gcacaaagcc ctaaggtaaa caaacaggaa     3900

agtgcacatt cagggaccca aagggttatc agcatggcca gagcatggga agtgaaggag     3960

ggggaggaga gaagtcagga gccagatcac atgtggtttt agagatgtgg gattttgtct     4020

taagggtgag ggaagctgtt gtgaacaggc atgtggctta atctcaggtt ataagactga     4080

cctggttgct atgtggagga tagaccacag ggggcaggaa tggaggctgg gagaccagca     4140

gaaggtgtga gtccaggcta gacacattgg cggcttggac caaggtggga cagtgaaggt     4200

ggaggcaagt ggactggaca tgttcccgtg ggtttagggg cagaatcaac aagacttggt     4260

acgtgcagtg gatgtgagaa gctgagggaa agaaaaagcc aaggatggtt tttgtcttga     4320

gcacctggat attccaatga tgctgaaacg gggatgatcc atgggcagag caggtttgag     4380

ggaagacagt tcagtctggg gcacagcaga cgtgaggtgc tcatgaaatg gtgagtggag     4440

acgttgagga ggcagctagg tgtgcgggtc ttgagtgtga ccagcaatgc acagatctat     4500

gaggcatggg ggttcggctt atctgtgaag ccatgggact ggacagcact gccactgtga     4560

gaagagaagc aggcccagga acccagcatt tggagggcaa gcagaggatg ggggacctgg     4620

caaggggcag cctgaaggtg ggaggaaaag agggagagtg cagagtcgag gcactgcatt     4680

ccaagatgga taagggatgg agattcataa aaaagcgttg agaaatcaag caaggtgagg     4740

gctaaaattg tccattggat ttggcaacgt gtcacacatg ctggatcagg gtgaacagaa     4800

agagaggaag tagagacacc actgtggaag aacttggatc cgaatggggg caggaaaaga     4860

gatgtagctg gagggagtgt gtaattgagg gaggactttt tgttctgttt ttgttgtcgt     4920

tgttttgaga cagggtctca ttctgtcacc caagctgaag ttcagcggcg caatcacgac     4980

tcactgcagc ccaacctccc aggctcaatt gatcctctga cttcagtctc ctgagtagct     5040

gggacaacag gcacacccca ctatgcccag ctattttttg tagagatagg gtttcgcaat     5100

gttgcccagg ctggtctcaa actcccaggc tcaagcaatc tgtctgcctt ggcctcccag     5160

agtgctggga ttacaaatgt gagttactgt gcctggccag gaaaacattt ttaataagag     5220

aggtattaaa tctgcggttt tccaacatta agattcctaa gaatcacttg gggaatgtgt     5280

tgaaaatgca tattcctagg acacacccct agagagtctg atacactggg tttaagagtg     5340

gctccagggc cgggcgcggt ggttcatgcc tctaatcctg gcactttggg aggccgagac     5400

agtggatcac ctgaggtcag gagttcaaga ccagcctgcc caacagggcg aaaccccatc     5460

tttactaaaa atacaaaaat tagcagctgg tggtggcgca tgcctgtaat ccaagctact     5520

cgggaggctg aggcagtaga atcgcttgac ccagggtggc ggaggttgca gtgagctgag     5580

atcgaaactc catctcaaaa taaataaata aataaataaa taaataaata aataaataaa     5640

taaataaaag actgaaccca ggaatctgca tcttaagcag ctgtcgcact gatgattatg     5700

acccccttgg atattcactt gtagacatgt gtgaatgctg aggggcaggc tccaagagag     5760

agggtgggtg aagctggagg agctagctcc cagcaagtct ctggagaaga cagtgggagg     5820

gattcagagc tcctgaggga gagtgagagt gagacttcat ctcaaaaaaa aaaaaaatgt     5880

ttaccagata gacgtacgaa tgagaagact gggctcagct ccatcactta ccagctaggt     5940

ggcagtgacc aagtaaactg ccggagtctc actctctccc aggctggagt gcagtagtgc     6000

catctcagct cactgcaacc tttgcctccc gggttcaagc aattctcctg cctcagcctc     6060

ccgagtagct gggattacag gcacgcacca ccatgcccag ctaatttttg tctttctagc     6120

tgggattaca ggcacgtgcc accatgcctg gctaattttt gtctttttag taaagacaag     6180

gtttcaccat gttggtcagg ctgatctcga actcctgacc tcgtgatcag cctgcctcgg     6240

cctcccaaca tgctgggatt acaggtgtga gccaccgcac ccggcctatc tggtaaacat     6300

ttcttaaggg ctgactgcat aggccaggga gatgcggcga tgccttcaag gacttcacag     6360

cctagaaaag cccatgtttc ttccctgtga agctcagttt aaggaaaaac ttggtatctg     6420

tgattcagtg gcatttaggc cctggatgaa gctgtgagca tgcatggcat ggccttgtgt     6480

gaaaggagag gtgggcccgg gagtgaaccc tgagggatgg cagcatttgg atatcaggag     6540

gagaagggga gcttggtaag gagacagaaa gagcagcttg aaaggtggga gaagacccag     6600

gatgatgcag cttctcagag ctccagtggg tgtgggaagc cggggcccct tgagcagcac     6660

agaagacagg gctgggacct cctcagccct ccctctaaga cacaccaatg ccagcaaagg     6720

acccatatgc ctggcggctg ccccgttccc ttctccacac cacagctcaa tgatttttct     6780

caaactcaac tcttaccatg ccactgccca cccctaacac cccttcagat gttttccctt     6840

tgctctgtgg acaaaactaa aagttctggt cttggcccac gaggccctca agacctggcc     6900

cttgctaacc tctctccatg tgcgtctctt gccacgctcc tcctagatgg tagtgctgca     6960

gccacaccag ccttctttta gtctttgggc ttttcatgca ttttcttgcc tcaggacttt     7020

tgcacggtct gttcttgcag cctggacagc tctctgggat cccatctctt tcctggtttc     7080

tcttgctcat cttttagttg attccttggg gaaattctcc ctgaacactt gtttagttcc     7140

ccttgttgca caccatcgga tggcccagta cttattcata ggactcattg cacttgtaac     7200

aatgtgttta gtccctgctg gattgctgga ctcagtgtcc aactcagcca ggaaccacct     7260

ctctcttgtt cgttgcatga ttcccaggta attaccatat gcctggcaca taaacatatg     7320

ttgaatgggt ctgtgaataa atgacatatc tcataacctc aggactcatt ctgctgcaaa     7380

ccaggggaaa ggggagcaag gaaacaaaag ggaaaaagaa gacagatgtg agaaaggcca     7440

agggaatttg acaaataaga tggagacatg gggccaatgg tcatgctcac aaaagggggc     7500

cctgatctcc ttccaggcct gcgtccgaac tttctatgag acacctctcc agttgctgga     7560

gaaggtcaag aatgtcttta atgaaacaaa gaatctcctt gacaaggact ggaatatttt     7620

cagcaagaac tgcaacaaca gctttgctga atgctccagc caaggtaagc atggcagggg     7680

ccagcaagtg tgtgggggtg gtagcatatg gaatggggat tgggaggtga gatgtgaagc     7740

tggggggacc cctggggagg cagcctggct gctactcgtg ttcccgtgtg catgaatgtg     7800

cttgttctgt gtatatatgt ggcttcacgt acctctggtc ctgggcacat gtcttttctg     7860

acatgtgtgt gcatgcacac ctacatatgt ctgcatgtgg cagcgtcaag aaggatcatg     7920

ctggtgcctt gagattaggg agtggaaatg ggagcctgtc ttgggagccc tgtaggtatg     7980

gaagctttcc ccactggctc tgcaggctgg ctgaacgtgt ggggggttct gtggagacag     8040

ctgacaccca tctgggagtc agggcccttg ctccaggagc tctgctgcga atcaccatga     8100

taccctggct ccagaagtcc ccaggatgcc ttgggtgttt cctcaaggga caaggctgga     8160

tttgaagtct gagcatcatt ggaactccca gggctggctc agctgcatac atgtgtacac     8220

tgcgtgtcct cgtctctgcg tctcgtgcca cacgtgccct cctacattca accttgcttc     8280

ccaaggcagg gtctagggcc ctgcaacctg ccagtggcca agtccagtct cgttgcttca     8340

atcccaagtc ctcaagcctt ggctgcattc tagccccagc ctgttcctgc ctgtggctgt     8400

ggctgtggct gtggctgtgt ggctcctggc tatgcatgaa accagtgtct ctggggcttg     8460

aagttgtctt gtattggtct ggaaggcaac cgttcagcct cctgacctga ctgctgctca     8520

cccctagctt ggcctgtggc cagtgggaac ccctgcatgg gctgttctct tatcttcctt     8580

ctccccaacc cccagtgtgt gcatctcaac cctattcttt gtcactgctc atgagaccct     8640

gcatacggca ccttccctgt gtcatgagca cccactctag tcccatcctc ttctcagccc     8700

cagggctgag ctaggagatg agggcccccc agactcacat tcccctcttg ccccgctctg     8760

ggaaagctgt gctggaggct agtgactcta tctcctcccc atctttctct ctccttctct     8820

ctgtggttct ttcagatgtg gtgaccaagc ctgattgcaa ctgcctgtac cccaaagcca     8880

tccctagcag tgacccggcc tctgtctccc ctcatcagcc cctcgccccc tccatggccc     8940

ctgtggctgg cttgacctgg gaggactctg agggaactga gggcagctcc ctcttgcctg     9000

gtgagcagcc cctgcacaca gtggatccag gcagtgccaa gcagcggcca cccaggagca     9060

cctgccagag ctttgagccg ccagagaccc cagttgtcaa ggacagcacc atcggtggct     9120

caccacagcc tcgcccctct gtcggggcct tcaaccccgg gatggaggat attcttgact     9180

ctgcaatggg cactaattgg gtcccagaag aagcctctgg agaggccagt gagattcccg     9240

taccccaagg gacagagctt tccccctcca ggccaggagg gggcagcatg cagacagagc     9300

ccgccagacc cagcaacttc ctctcagcat cttctccact ccctgcatca gcaaagggcc     9360

aacagccggc agatgtaact ggtaccgcct tgcccagggt gggccccgtg aggcccactg     9420

gccaggactg gaatcacacc ccccagaaga cagaccatcc atctgccctg ctcagagacc     9480

ccccggagcc aggctctccc aggatctcat cactgcgccc ccagggcctc agcaacccct     9540

ccaccctctc tgctcagcca cagctttcca gaagccactc ctcgggcagc gtgctgcccc     9600

ttggggagct ggagggcagg aggagcacca gggatcggag gagccccgca gagccagaag     9660

gaggaccagc aagtgaaggg gcagccaggc ccctgccccg ttttaactcc gttcctttga     9720

ctgacacagg ccatgagagg cagtccgagg gatccttcag cccgcagctc caggagtctg     9780

tcttccacct gctggtgccc agtgtcatcc tggtcttgct ggccgtcgga ggcctcttgt     9840

tctacaggtg gaggcggcgg gtgagtagat ccccatgagg aagaagagca cgtcccttag     9900

ggcaggggca gagcctggcg ggggtgcagg tggggggaca gcttgggtgc ggcctgagtt     9960

cttcagacac agagagatag gggctggctc agcacagagg atgagaggtg gaaatggagg    10020

attacttcga gaattgggaa ggttcaagct ataaggtcaa tgggaaggga ctggagcaga    10080

agggagcggg agagaatatt catgggctga cagcaggatg atatccagac gggcagggag    10140

ctggaggagg agagcaatgc tgtgtgagcg tgtcagggca ggcgtacact ggaagctctg    10200

cagagcctgg ggcaggagga cccataggga acagcctgca agggtgtggg gagaggagag    10260

gggacaccat cagcagagag acctcacaaa tctcccttgg gcctctggct gatccccact    10320

tttgggaagt tgggaggact cttgcaactc tctcataaat acctggggca gcccttactg    10380

gggatgggcc accgcccccc cacactcccc cagctcctca gtgagatgct ctttcctgtc    10440

ctcagagcca tcaagagcct cagagagcgg attctccctt ggagcaacca gagggcaggt    10500

gagagcttga ggtggggctc tgggaggcac tgggggcctg gcttgggatc tgtttcccct    10560

cttcgtggtg gtggggctct cctgcttgct ctgaggaaat ggagctgcag aacaggatgg    10620

gggagagaag aagggcctct gtcctttccc agatatctgg gctttttcct gatttctccg    10680

tagagttaga cagttctggg tcttttcaat ctgagagggc ctagagcatg tctggggctt    10740

aggggtaaac ttacggagtc cccttattcc cctgctcctg ctgatgtcta ataccagccc    10800

tgtgctctgc ctgcagcccc ctgactcagg atgacagaca ggtggaactg ccagtgtag     10859


<210>  6
<211>  80
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  connection between the 3' end of the human CSF1 DNA fragment in 
       the A1 fragment and the mouse CSF1 gene

<400>  6
cctgactcag gatgacagac aggtggaact gccagtgtag aaaggattct atggtaaggt       60

tctgattttg atatctctct                                                   80


<210>  7
<211>  100
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  connection between the 5' end of the Neo cassette and the mouse 
       sequence

<400>  7
ccagcttggt gctgagccct gacctcctca gcatcctctt cttgccaaat caccttgtga       60

agcttgatat cgaattccga agttcctatt ctctagaaag                            100


<210>  8
<211>  100
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  connection between the 3' end of the Neo cassette and the mouse 
       sequence

<400>  8
tctctagaaa gtataggaac ttcatcagtc aggtacataa tggtggatcc tgtgccttat       60

ctggtcctac tcccaagcca aggttattgc tgcctccctg                            100


<210>  9
<211>  4198
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  mRNA sequence of the engineered mouse CSF1 after humanization

<400>  9
acagagcgac ggggaagaga gctagcgggg acgaccaggc ggcccgcttg ggggaaggga       60

gtcggcggct cagtgggcct ctggggtgta gtatgtgtca gtgcctgtga gtgtgtttgt      120

gtgtgtgtat gtctgtgtgt gtctggcgga gagccagggt gatttcccat aaaccacatg      180

ccccgccagc ccgcccgctt aaaaggctgt gccgagggct ggccagcgaa gctcggccag      240

gggaaagtga aagtttgcct cggtgctctc ggtgtcgctg cggctctctg catcccagga      300

cagcggcgtg gccctcgacc ggggcgcggg ctcttcagcc actagcgagc aagggagcga      360

gcgaaccagg gcggccaaca cgccgtgccg ggacccagct gcccgtatga ccgcgcgggg      420

cgccgcgggg cgctgccctt cttcgacatg gctgggctcc cggctgctgc tggtctgtct      480

cctcatgagc aggagtattg ccaaggaggt gtcagaatac tgtagccaca tgattgggag      540

tggacacctg cagtctctgc agcggctgat tgacagtcag atggagacct cgtgccaaat      600

tacatttgag tttgtagacc aggaacagtt gaaagatcca gtgtgctacc ttaagaaggc      660

atttctcctg gtacaagaca taatggagga caccatgcgc ttcagagata acacccccaa      720

tgccatcgcc attgtgcagc tgcaggaact ctctttgagg ctgaagagct gcttcaccaa      780

ggattatgaa gagcatgaca aggcctgcgt ccgaactttc tatgagacac ctctccagtt      840

gctggagaag gtcaagaatg tctttaatga aacaaagaat ctccttgaca aggactggaa      900

tattttcagc aagaactgca acaacagctt tgctgaatgc tccagccaag atgtggtgac      960

caagcctgat tgcaactgcc tgtaccccaa agccatccct agcagtgacc cggcctctgt     1020

ctcccctcat cagcccctcg ccccctccat ggcccctgtg gctggcttga cctgggagga     1080

ctctgaggga actgagggca gctccctctt gcctggtgag cagcccctgc acacagtgga     1140

tccaggcagt gccaagcagc ggccacccag gagcacctgc cagagctttg agccgccaga     1200

gaccccagtt gtcaaggaca gcaccatcgg tggctcacca cagcctcgcc cctctgtcgg     1260

ggccttcaac cccgggatgg aggatattct tgactctgca atgggcacta attgggtccc     1320

agaagaagcc tctggagagg ccagtgagat tcccgtaccc caagggacag agctttcccc     1380

ctccaggcca ggagggggca gcatgcagac agagcccgcc agacccagca acttcctctc     1440

agcatcttct ccactccctg catcagcaaa gggccaacag ccggcagatg taactggtac     1500

cgccttgccc agggtgggcc ccgtgaggcc cactggccag gactggaatc acacccccca     1560

gaagacagac catccatctg ccctgctcag agaccccccg gagccaggct ctcccaggat     1620

ctcatcactg cgcccccagg gcctcagcaa cccctccacc ctctctgctc agccacagct     1680

ttccagaagc cactcctcgg gcagcgtgct gccccttggg gagctggagg gcaggaggag     1740

caccagggat cggaggagcc ccgcagagcc agaaggagga ccagcaagtg aaggggcagc     1800

caggcccctg ccccgtttta actccgttcc tttgactgac acaggccatg agaggcagtc     1860

cgagggatcc ttcagcccgc agctccagga gtctgtcttc cacctgctgg tgcccagtgt     1920

catcctggtc ttgctggccg tcggaggcct cttgttctac aggtggaggc ggcggagcca     1980

tcaagagcct cagagagcgg attctccctt ggagcaacca gagggcagcc ccctgactca     2040

ggatgacaga caggtggaac tgccagtgta gaaaggattc tatgctgggc acacaggact     2100

atctctttat ggaaggagac atatgggaac atccaccact accctctcct accatcttcc     2160

tgggaatgtg gcctaccact accagagctc ctgcctacca agactggatg aaagaagcag     2220

ctttgatggg gtctttccat cctcaccctt agactctcaa ccaaagagaa agggctggag     2280

gatgcccccc acatactgcc actatttatt gtgggccctg gaggctccct gcattggagg     2340

aagggcagct cagcagctca ggaccctttc ccttaggggc tgcttcctcc cctcaaaacc     2400

agaacctggc aagggactca ctagcctgga tggcccatgg gagaccagga cagatgagaa     2460

ggagcagaag agccctgtgc ccagaagacc caactggtgc caaggaatcc cagcatggac     2520

aggcagggac ctgtttccca agaagagagc ctgatattca aagggtggga cagcatctgc     2580

ccgacttccc gtaaaggcat aaaggcacgc agcccaaaag acgggaagag gaggcctttg     2640

gctgcttgtg ttgacagctt aaaggggtct acaccctcaa cttgcttaag tgccctctgc     2700

tgatagccag gaaggaggga gaccagccct gcccctcagg acctgacctg gctcatgatg     2760

ccaagaggaa gacagagctc tagcctcgtc ttctcctgcc cacagcccct gccagagttc     2820

ttttgcccag cagaggcacc cctcatgaag gaagccattg cactgtgaat actgaacctg     2880

cctgctgaac agcctgtccc atccatccct atgagtgacc atccgtccga atgttctccc     2940

acttccttca gcctctcctc ggcttcttgc actgagctgg cctcacgtgt tgactgaggg     3000

agcccctgag ccccaacctt cccctgcctc agcctttgat tgtccagggt gaagctgtgg     3060

gagaaccgcc tgggctacca gtcagagctg gtctttgggc tgtgttcctt gcccaggttt     3120

ctgcatcttg cactttgaca ttcccaggag ggaagtgact agtggaaggg agagaggaag     3180

gggaggcaga gacaaaggcc acaggcagag ctatgaatga gaatgggtct tgaaaatatg     3240

tgtgcacccc taagcttgaa attgatctct atactctagc ccctcagcca gcctccttcc     3300

tgttgtctga aacctggagc taagcaggtt gtcctgtcac aagctctggg gactgagctc     3360

catgctccaa ccccaccctc ttctgacctt tgttctccag acctgaccca ggtaggcaag     3420

ggtaccctcc cagtctcacc taccatactg tgccatctct agccaagcaa gccaggttta     3480

gagaagggtc aaaaaaaaaa aaaagggttg tttacttcca acttgttctg atgccctctg     3540

tttcccaggc caggcttgtc tgtggtgacc tgggcatggg tgacagggct ctcatttgcc     3600

ccttggtctc tttatgctgc tgagtccccc tttcctgccc tccctggcta ctgggtcaat     3660

aatctttcag gccatgaatc tgggaggaga gtggtctgta agctccatca gccctgtcct     3720

gagacagcag gggggaagga cactggagac tttcttgtgg ggcttactta gccttctggt     3780

tacagactat ttccatgcta gaaaatacat attttaaaat agaaggaaaa acacagaaac     3840

aaaacaaaac aaggcattct ctacccctcc accttaaaca tatattatta aagacagaag     3900

agaaaatcca acccattgca agaagctctt tgtgggtgcc tggttacatc ggagcagggg     3960

agcctcaaat ccacctttgg agccgcccct gtgtgcatta ggaacccttc tctcctctga     4020

gaaagctcag agggagcact gcctcacaaa ctgtgagact gcgtttttta tacttggaag     4080

tggtgaatta ttttatataa ggtcatttaa atatctattt aaaaaatagg aagctgcttt     4140

tatatttaat aataaaagaa gtgcacaagc tgccacgtgt gaaaaaaaaa aaaaaaaa       4198


<210>  10
<211>  554
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  protein sequence of the engineered mouse CSF1 after humanization

<400>  10

Met Thr Ala Arg Gly Ala Ala Gly Arg Cys Pro Ser Ser Thr Trp Leu 
1               5                   10                  15      


Gly Ser Arg Leu Leu Leu Val Cys Leu Leu Met Ser Arg Ser Ile Ala 
            20                  25                  30          


Lys Glu Val Ser Glu Tyr Cys Ser His Met Ile Gly Ser Gly His Leu 
        35                  40                  45              


Gln Ser Leu Gln Arg Leu Ile Asp Ser Gln Met Glu Thr Ser Cys Gln 
    50                  55                  60                  


Ile Thr Phe Glu Phe Val Asp Gln Glu Gln Leu Lys Asp Pro Val Cys 
65                  70                  75                  80  


Tyr Leu Lys Lys Ala Phe Leu Leu Val Gln Asp Ile Met Glu Asp Thr 
                85                  90                  95      


Met Arg Phe Arg Asp Asn Thr Pro Asn Ala Ile Ala Ile Val Gln Leu 
            100                 105                 110         


Gln Glu Leu Ser Leu Arg Leu Lys Ser Cys Phe Thr Lys Asp Tyr Glu 
        115                 120                 125             


Glu His Asp Lys Ala Cys Val Arg Thr Phe Tyr Glu Thr Pro Leu Gln 
    130                 135                 140                 


Leu Leu Glu Lys Val Lys Asn Val Phe Asn Glu Thr Lys Asn Leu Leu 
145                 150                 155                 160 


Asp Lys Asp Trp Asn Ile Phe Ser Lys Asn Cys Asn Asn Ser Phe Ala 
                165                 170                 175     


Glu Cys Ser Ser Gln Asp Val Val Thr Lys Pro Asp Cys Asn Cys Leu 
            180                 185                 190         


Tyr Pro Lys Ala Ile Pro Ser Ser Asp Pro Ala Ser Val Ser Pro His 
        195                 200                 205             


Gln Pro Leu Ala Pro Ser Met Ala Pro Val Ala Gly Leu Thr Trp Glu 
    210                 215                 220                 


Asp Ser Glu Gly Thr Glu Gly Ser Ser Leu Leu Pro Gly Glu Gln Pro 
225                 230                 235                 240 


Leu His Thr Val Asp Pro Gly Ser Ala Lys Gln Arg Pro Pro Arg Ser 
                245                 250                 255     


Thr Cys Gln Ser Phe Glu Pro Pro Glu Thr Pro Val Val Lys Asp Ser 
            260                 265                 270         


Thr Ile Gly Gly Ser Pro Gln Pro Arg Pro Ser Val Gly Ala Phe Asn 
        275                 280                 285             


Pro Gly Met Glu Asp Ile Leu Asp Ser Ala Met Gly Thr Asn Trp Val 
    290                 295                 300                 


Pro Glu Glu Ala Ser Gly Glu Ala Ser Glu Ile Pro Val Pro Gln Gly 
305                 310                 315                 320 


Thr Glu Leu Ser Pro Ser Arg Pro Gly Gly Gly Ser Met Gln Thr Glu 
                325                 330                 335     


Pro Ala Arg Pro Ser Asn Phe Leu Ser Ala Ser Ser Pro Leu Pro Ala 
            340                 345                 350         


Ser Ala Lys Gly Gln Gln Pro Ala Asp Val Thr Gly Thr Ala Leu Pro 
        355                 360                 365             


Arg Val Gly Pro Val Arg Pro Thr Gly Gln Asp Trp Asn His Thr Pro 
    370                 375                 380                 


Gln Lys Thr Asp His Pro Ser Ala Leu Leu Arg Asp Pro Pro Glu Pro 
385                 390                 395                 400 


Gly Ser Pro Arg Ile Ser Ser Leu Arg Pro Gln Gly Leu Ser Asn Pro 
                405                 410                 415     


Ser Thr Leu Ser Ala Gln Pro Gln Leu Ser Arg Ser His Ser Ser Gly 
            420                 425                 430         


Ser Val Leu Pro Leu Gly Glu Leu Glu Gly Arg Arg Ser Thr Arg Asp 
        435                 440                 445             


Arg Arg Ser Pro Ala Glu Pro Glu Gly Gly Pro Ala Ser Glu Gly Ala 
    450                 455                 460                 


Ala Arg Pro Leu Pro Arg Phe Asn Ser Val Pro Leu Thr Asp Thr Gly 
465                 470                 475                 480 


His Glu Arg Gln Ser Glu Gly Ser Phe Ser Pro Gln Leu Gln Glu Ser 
                485                 490                 495     


Val Phe His Leu Leu Val Pro Ser Val Ile Leu Val Leu Leu Ala Val 
            500                 505                 510         


Gly Gly Leu Leu Phe Tyr Arg Trp Arg Arg Arg Ser His Gln Glu Pro 
        515                 520                 525             


Gln Arg Ala Asp Ser Pro Leu Glu Gln Pro Glu Gly Ser Pro Leu Thr 
    530                 535                 540                 


Gln Asp Asp Arg Gln Val Glu Leu Pro Val 
545                 550                 


<210>  11
<211>  23
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  primer

<400>  11
gagccagggt gatttcccat aaa                                               23


<210>  12
<211>  23
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  primer

<400>  12
cagaggtcct aactttggga agg                                               23


<210>  13
<211>  20
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  primer

<400>  13
gctcgactag agcttgcgga                                                   20


<210>  14
<211>  23
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  primer

<400>  14
agagggcact taagcaagtt gag                                               23


<210>  15
<211>  23
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  primer

<400>  15
ttgaacaatg cataggaggg agc                                               23


<210>  16
<211>  20
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  primer

<400>  16
gctagctctc ttccccgtcg                                                   20


<210>  17
<211>  22
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  primer

<400>  17
ttcccgtaaa ggcataaagg ca                                                22


<210>  18
<211>  21
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  primer

<400>  18
gaggagaggc tgaaggaagt g                                                 21


<210>  19
<211>  21
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  primer

<400>  19
ggatcggcca ttgaacaaga t                                                 21


<210>  20
<211>  22
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  primer

<400>  20
cagaagaact cgtcaagaag gc                                                22


<210>  21
<211>  22
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  primer

<400>  21
gcgttgtttc tttgccctta gt                                                22


<210>  22
<211>  23
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  primer

<400>  22
gtaccaggag agccattatc cac                                               23


<210>  23
<211>  23
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  primer

<400>  23
cagaggtcct aactttggga agg                                               23


<210>  24
<211>  23
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  primer

<400>  24
tacatctgat cccaaagcaa cca                                               23


<210>  25
<211>  23
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  primer

<400>  25
ggggatgcag agtaaccctt tta                                               23


<210>  26
<211>  25
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  primer

<400>  26
gacaagcgtt agtaggcaca tatac                                             25


<210>  27
<211>  24
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  primer

<400>  27
gctccaattt cccacaacat tagt                                              24


<210>  28
<211>  20
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  primer

<400>  28
aaggcctgtg tccgaacttt                                                   20


<210>  29
<211>  20
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  primer

<400>  29
tggaggggga aaactttgct                                                   20


<210>  30
<211>  20
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  primer

<400>  30
tctgtctccc ctcatcagcc                                                   20


<210>  31
<211>  20
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  primer

<400>  31
cttgctggtc ctccttctgg                                                   20


<210>  32
<211>  20
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  primer

<400>  32
accacagtcc atgccatcac                                                   20


<210>  33
<211>  20
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  primer

<400>  33
gcctgcttca ccaccttctt                                                   20


<210>  34
<211>  977
<212>  PRT
<213>  Mus musculus

<400>  34

Met Glu Leu Gly Pro Pro Leu Val Leu Leu Leu Ala Thr Val Trp His 
1               5                   10                  15      


Gly Gln Gly Ala Pro Val Ile Glu Pro Ser Gly Pro Glu Leu Val Val 
            20                  25                  30          


Glu Pro Gly Glu Thr Val Thr Leu Arg Cys Val Ser Asn Gly Ser Val 
        35                  40                  45              


Glu Trp Asp Gly Pro Ile Ser Pro Tyr Trp Thr Leu Asp Pro Glu Ser 
    50                  55                  60                  


Pro Gly Ser Thr Leu Thr Thr Arg Asn Ala Thr Phe Lys Asn Thr Gly 
65                  70                  75                  80  


Thr Tyr Arg Cys Thr Glu Leu Glu Asp Pro Met Ala Gly Ser Thr Thr 
                85                  90                  95      


Ile His Leu Tyr Val Lys Asp Pro Ala His Ser Trp Asn Leu Leu Ala 
            100                 105                 110         


Gln Glu Val Thr Val Val Glu Gly Gln Glu Ala Val Leu Pro Cys Leu 
        115                 120                 125             


Ile Thr Asp Pro Ala Leu Lys Asp Ser Val Ser Leu Met Arg Glu Gly 
    130                 135                 140                 


Gly Arg Gln Val Leu Arg Lys Thr Val Tyr Phe Phe Ser Pro Trp Arg 
145                 150                 155                 160 


Gly Phe Ile Ile Arg Lys Ala Lys Val Leu Asp Ser Asn Thr Tyr Val 
                165                 170                 175     


Cys Lys Thr Met Val Asn Gly Arg Glu Ser Thr Ser Thr Gly Ile Trp 
            180                 185                 190         


Leu Lys Val Asn Arg Val His Pro Glu Pro Pro Gln Ile Lys Leu Glu 
        195                 200                 205             


Pro Ser Lys Leu Val Arg Ile Arg Gly Glu Ala Ala Gln Ile Val Cys 
    210                 215                 220                 


Ser Ala Thr Asn Ala Glu Val Gly Phe Asn Val Ile Leu Lys Arg Gly 
225                 230                 235                 240 


Asp Thr Lys Leu Glu Ile Pro Leu Asn Ser Asp Phe Gln Asp Asn Tyr 
                245                 250                 255     


Tyr Lys Lys Val Arg Ala Leu Ser Leu Asn Ala Val Asp Phe Gln Asp 
            260                 265                 270         


Ala Gly Ile Tyr Ser Cys Val Ala Ser Asn Asp Val Gly Thr Arg Thr 
        275                 280                 285             


Ala Thr Met Asn Phe Gln Val Val Glu Ser Ala Tyr Leu Asn Leu Thr 
    290                 295                 300                 


Ser Glu Gln Ser Leu Leu Gln Glu Val Ser Val Gly Asp Ser Leu Ile 
305                 310                 315                 320 


Leu Thr Val His Ala Asp Ala Tyr Pro Ser Ile Gln His Tyr Asn Trp 
                325                 330                 335     


Thr Tyr Leu Gly Pro Phe Phe Glu Asp Gln Arg Lys Leu Glu Phe Ile 
            340                 345                 350         


Thr Gln Arg Ala Ile Tyr Arg Tyr Thr Phe Lys Leu Phe Leu Asn Arg 
        355                 360                 365             


Val Lys Ala Ser Glu Ala Gly Gln Tyr Phe Leu Met Ala Gln Asn Lys 
    370                 375                 380                 


Ala Gly Trp Asn Asn Leu Thr Phe Glu Leu Thr Leu Arg Tyr Pro Pro 
385                 390                 395                 400 


Glu Val Ser Val Thr Trp Met Pro Val Asn Gly Ser Asp Val Leu Phe 
                405                 410                 415     


Cys Asp Val Ser Gly Tyr Pro Gln Pro Ser Val Thr Trp Met Glu Cys 
            420                 425                 430         


Arg Gly His Thr Asp Arg Cys Asp Glu Ala Gln Ala Leu Gln Val Trp 
        435                 440                 445             


Asn Asp Thr His Pro Glu Val Leu Ser Gln Lys Pro Phe Asp Lys Val 
    450                 455                 460                 


Ile Ile Gln Ser Gln Leu Pro Ile Gly Thr Leu Lys His Asn Met Thr 
465                 470                 475                 480 


Tyr Phe Cys Lys Thr His Asn Ser Val Gly Asn Ser Ser Gln Tyr Phe 
                485                 490                 495     


Arg Ala Val Ser Leu Gly Gln Ser Lys Gln Leu Pro Asp Glu Ser Leu 
            500                 505                 510         


Phe Thr Pro Val Val Val Ala Cys Met Ser Val Met Ser Leu Leu Val 
        515                 520                 525             


Leu Leu Leu Leu Leu Leu Leu Tyr Lys Tyr Lys Gln Lys Pro Lys Tyr 
    530                 535                 540                 


Gln Val Arg Trp Lys Ile Ile Glu Arg Tyr Glu Gly Asn Ser Tyr Thr 
545                 550                 555                 560 


Phe Ile Asp Pro Thr Gln Leu Pro Tyr Asn Glu Lys Trp Glu Phe Pro 
                565                 570                 575     


Arg Asn Asn Leu Gln Phe Gly Lys Thr Leu Gly Ala Gly Ala Phe Gly 
            580                 585                 590         


Lys Val Val Glu Ala Thr Ala Phe Gly Leu Gly Lys Glu Asp Ala Val 
        595                 600                 605             


Leu Lys Val Ala Val Lys Met Leu Lys Ser Thr Ala His Ala Asp Glu 
    610                 615                 620                 


Lys Glu Ala Leu Met Ser Glu Leu Lys Ile Met Ser His Leu Gly Gln 
625                 630                 635                 640 


His Glu Asn Ile Val Asn Leu Leu Gly Ala Cys Thr His Gly Gly Pro 
                645                 650                 655     


Val Leu Val Ile Thr Glu Tyr Cys Cys Tyr Gly Asp Leu Leu Asn Phe 
            660                 665                 670         


Leu Arg Arg Lys Ala Glu Ala Met Leu Gly Pro Ser Leu Ser Pro Gly 
        675                 680                 685             


Gln Asp Ser Glu Gly Asp Ser Ser Tyr Lys Asn Ile His Leu Glu Lys 
    690                 695                 700                 


Lys Tyr Val Arg Arg Asp Ser Gly Phe Ser Ser Gln Gly Val Asp Thr 
705                 710                 715                 720 


Tyr Val Glu Met Arg Pro Val Ser Thr Ser Ser Ser Asp Ser Phe Phe 
                725                 730                 735     


Lys Gln Asp Leu Asp Lys Glu Ala Ser Arg Pro Leu Glu Leu Trp Asp 
            740                 745                 750         


Leu Leu His Phe Ser Ser Gln Val Ala Gln Gly Met Ala Phe Leu Ala 
        755                 760                 765             


Ser Lys Asn Cys Ile His Arg Asp Val Ala Ala Arg Asn Val Leu Leu 
    770                 775                 780                 


Thr Ser Gly His Val Ala Lys Ile Gly Asp Phe Gly Leu Ala Arg Asp 
785                 790                 795                 800 


Ile Met Asn Asp Ser Asn Tyr Val Val Lys Gly Asn Ala Arg Leu Pro 
                805                 810                 815     


Val Lys Trp Met Ala Pro Glu Ser Ile Phe Asp Cys Val Tyr Thr Val 
            820                 825                 830         


Gln Ser Asp Val Trp Ser Tyr Gly Ile Leu Leu Trp Glu Ile Phe Ser 
        835                 840                 845             


Leu Gly Leu Asn Pro Tyr Pro Gly Ile Leu Val Asn Asn Lys Phe Tyr 
    850                 855                 860                 


Lys Leu Val Lys Asp Gly Tyr Gln Met Ala Gln Pro Val Phe Ala Pro 
865                 870                 875                 880 


Lys Asn Ile Tyr Ser Ile Met Gln Ser Cys Trp Asp Leu Glu Pro Thr 
                885                 890                 895     


Arg Arg Pro Thr Phe Gln Gln Ile Cys Phe Leu Leu Gln Glu Gln Ala 
            900                 905                 910         


Arg Leu Glu Arg Arg Asp Gln Asp Tyr Ala Asn Leu Pro Ser Ser Gly 
        915                 920                 925             


Gly Ser Ser Gly Ser Asp Ser Gly Gly Gly Ser Ser Gly Gly Ser Ser 
    930                 935                 940                 


Ser Glu Pro Glu Glu Glu Ser Ser Ser Glu His Leu Ala Cys Cys Glu 
945                 950                 955                 960 


Pro Gly Asp Ile Ala Gln Pro Leu Leu Gln Pro Asn Asn Tyr Gln Phe 
                965                 970                 975     


Cys 
    


<210>  35
<211>  972
<212>  PRT
<213>  Homo sapiens

<400>  35

Met Gly Pro Gly Val Leu Leu Leu Leu Leu Val Ala Thr Ala Trp His 
1               5                   10                  15      


Gly Gln Gly Ile Pro Val Ile Glu Pro Ser Val Pro Glu Leu Val Val 
            20                  25                  30          


Lys Pro Gly Ala Thr Val Thr Leu Arg Cys Val Gly Asn Gly Ser Val 
        35                  40                  45              


Glu Trp Asp Gly Pro Pro Ser Pro His Trp Thr Leu Tyr Ser Asp Gly 
    50                  55                  60                  


Ser Ser Ser Ile Leu Ser Thr Asn Asn Ala Thr Phe Gln Asn Thr Gly 
65                  70                  75                  80  


Thr Tyr Arg Cys Thr Glu Pro Gly Asp Pro Leu Gly Gly Ser Ala Ala 
                85                  90                  95      


Ile His Leu Tyr Val Lys Asp Pro Ala Arg Pro Trp Asn Val Leu Ala 
            100                 105                 110         


Gln Glu Val Val Val Phe Glu Asp Gln Asp Ala Leu Leu Pro Cys Leu 
        115                 120                 125             


Leu Thr Asp Pro Val Leu Glu Ala Gly Val Ser Leu Val Arg Val Arg 
    130                 135                 140                 


Gly Arg Pro Leu Met Arg His Thr Asn Tyr Ser Phe Ser Pro Trp His 
145                 150                 155                 160 


Gly Phe Thr Ile His Arg Ala Lys Phe Ile Gln Ser Gln Asp Tyr Gln 
                165                 170                 175     


Cys Ser Ala Leu Met Gly Gly Arg Lys Val Met Ser Ile Ser Ile Arg 
            180                 185                 190         


Leu Lys Val Gln Lys Val Ile Pro Gly Pro Pro Ala Leu Thr Leu Val 
        195                 200                 205             


Pro Ala Glu Leu Val Arg Ile Arg Gly Glu Ala Ala Gln Ile Val Cys 
    210                 215                 220                 


Ser Ala Ser Ser Val Asp Val Asn Phe Asp Val Phe Leu Gln His Asn 
225                 230                 235                 240 


Asn Thr Lys Leu Ala Ile Pro Gln Gln Ser Asp Phe His Asn Asn Arg 
                245                 250                 255     


Tyr Gln Lys Val Leu Thr Leu Asn Leu Asp Gln Val Asp Phe Gln His 
            260                 265                 270         


Ala Gly Asn Tyr Ser Cys Val Ala Ser Asn Val Gln Gly Lys His Ser 
        275                 280                 285             


Thr Ser Met Phe Phe Arg Val Val Glu Ser Ala Tyr Leu Asn Leu Ser 
    290                 295                 300                 


Ser Glu Gln Asn Leu Ile Gln Glu Val Thr Val Gly Glu Gly Leu Asn 
305                 310                 315                 320 


Leu Lys Val Met Val Glu Ala Tyr Pro Gly Leu Gln Gly Phe Asn Trp 
                325                 330                 335     


Thr Tyr Leu Gly Pro Phe Ser Asp His Gln Pro Glu Pro Lys Leu Ala 
            340                 345                 350         


Asn Ala Thr Thr Lys Asp Thr Tyr Arg His Thr Phe Thr Leu Ser Leu 
        355                 360                 365             


Pro Arg Leu Lys Pro Ser Glu Ala Gly Arg Tyr Ser Phe Leu Ala Arg 
    370                 375                 380                 


Asn Pro Gly Gly Trp Arg Ala Leu Thr Phe Glu Leu Thr Leu Arg Tyr 
385                 390                 395                 400 


Pro Pro Glu Val Ser Val Ile Trp Thr Phe Ile Asn Gly Ser Gly Thr 
                405                 410                 415     


Leu Leu Cys Ala Ala Ser Gly Tyr Pro Gln Pro Asn Val Thr Trp Leu 
            420                 425                 430         


Gln Cys Ser Gly His Thr Asp Arg Cys Asp Glu Ala Gln Val Leu Gln 
        435                 440                 445             


Val Trp Asp Asp Pro Tyr Pro Glu Val Leu Ser Gln Glu Pro Phe His 
    450                 455                 460                 


Lys Val Thr Val Gln Ser Leu Leu Thr Val Glu Thr Leu Glu His Asn 
465                 470                 475                 480 


Gln Thr Tyr Glu Cys Arg Ala His Asn Ser Val Gly Ser Gly Ser Trp 
                485                 490                 495     


Ala Phe Ile Pro Ile Ser Ala Gly Ala His Thr His Pro Pro Asp Glu 
            500                 505                 510         


Phe Leu Phe Thr Pro Val Val Val Ala Cys Met Ser Ile Met Ala Leu 
        515                 520                 525             


Leu Leu Leu Leu Leu Leu Leu Leu Leu Tyr Lys Tyr Lys Gln Lys Pro 
    530                 535                 540                 


Lys Tyr Gln Val Arg Trp Lys Ile Ile Glu Ser Tyr Glu Gly Asn Ser 
545                 550                 555                 560 


Tyr Thr Phe Ile Asp Pro Thr Gln Leu Pro Tyr Asn Glu Lys Trp Glu 
                565                 570                 575     


Phe Pro Arg Asn Asn Leu Gln Phe Gly Lys Thr Leu Gly Ala Gly Ala 
            580                 585                 590         


Phe Gly Lys Val Val Glu Ala Thr Ala Phe Gly Leu Gly Lys Glu Asp 
        595                 600                 605             


Ala Val Leu Lys Val Ala Val Lys Met Leu Lys Ser Thr Ala His Ala 
    610                 615                 620                 


Asp Glu Lys Glu Ala Leu Met Ser Glu Leu Lys Ile Met Ser His Leu 
625                 630                 635                 640 


Gly Gln His Glu Asn Ile Val Asn Leu Leu Gly Ala Cys Thr His Gly 
                645                 650                 655     


Gly Pro Val Leu Val Ile Thr Glu Tyr Cys Cys Tyr Gly Asp Leu Leu 
            660                 665                 670         


Asn Phe Leu Arg Arg Lys Ala Glu Ala Met Leu Gly Pro Ser Leu Ser 
        675                 680                 685             


Pro Gly Gln Asp Pro Glu Gly Gly Val Asp Tyr Lys Asn Ile His Leu 
    690                 695                 700                 


Glu Lys Lys Tyr Val Arg Arg Asp Ser Gly Phe Ser Ser Gln Gly Val 
705                 710                 715                 720 


Asp Thr Tyr Val Glu Met Arg Pro Val Ser Thr Ser Ser Asn Asp Ser 
                725                 730                 735     


Phe Ser Glu Gln Asp Leu Asp Lys Glu Asp Gly Arg Pro Leu Glu Leu 
            740                 745                 750         


Arg Asp Leu Leu His Phe Ser Ser Gln Val Ala Gln Gly Met Ala Phe 
        755                 760                 765             


Leu Ala Ser Lys Asn Cys Ile His Arg Asp Val Ala Ala Arg Asn Val 
    770                 775                 780                 


Leu Leu Thr Asn Gly His Val Ala Lys Ile Gly Asp Phe Gly Leu Ala 
785                 790                 795                 800 


Arg Asp Ile Met Asn Asp Ser Asn Tyr Ile Val Lys Gly Asn Ala Arg 
                805                 810                 815     


Leu Pro Val Lys Trp Met Ala Pro Glu Ser Ile Phe Asp Cys Val Tyr 
            820                 825                 830         


Thr Val Gln Ser Asp Val Trp Ser Tyr Gly Ile Leu Leu Trp Glu Ile 
        835                 840                 845             


Phe Ser Leu Gly Leu Asn Pro Tyr Pro Gly Ile Leu Val Asn Ser Lys 
    850                 855                 860                 


Phe Tyr Lys Leu Val Lys Asp Gly Tyr Gln Met Ala Gln Pro Ala Phe 
865                 870                 875                 880 


Ala Pro Lys Asn Ile Tyr Ser Ile Met Gln Ala Cys Trp Ala Leu Glu 
                885                 890                 895     


Pro Thr His Arg Pro Thr Phe Gln Gln Ile Cys Ser Phe Leu Gln Glu 
            900                 905                 910         


Gln Ala Gln Glu Asp Arg Arg Glu Arg Asp Tyr Thr Asn Leu Pro Ser 
        915                 920                 925             


Ser Ser Arg Ser Gly Gly Ser Gly Ser Ser Ser Ser Glu Leu Glu Glu 
    930                 935                 940                 


Glu Ser Ser Ser Glu His Leu Thr Cys Cys Glu Gln Gly Asp Ile Ala 
945                 950                 955                 960 


Gln Pro Leu Leu Gln Pro Asn Asn Tyr Gln Phe Cys 
                965                 970         


<210>  36
<211>  4629
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  5' arm

<400>  36
cagcaagtca gggtctgacc acttgcccta gaaatcaact atgaaaagtg attgctagag       60

gcaggaacag acttgaagcg tccaaggccc tgtctctggg gaagagttca ggtttaacta      120

taagaagacc tggttcagcg gggcaagagt cctgctcaca gtgggtgctg ttggatttta      180

ccagttggtc ccagaggagt tattcctggc tttcatggct tgaggaaaca gtttggtccc      240

catggctcat atttaggggt aacttcattt cttctcatgg ggtgaccgct ctcacctagg      300

gggataatgt catcatggag tgatttgtct acaggacttg ttatttttgg aacctagaat      360

aagtttggtt taggacaatt agtggagact tccagttgct gctataggag gctcattact      420

gtcaaagtcc aaatctccag ttaccttgag gccttctgcc ttaagggcag atgagaaagg      480

tatgaagaat gtaggataac ctgacctctc tcagccaggc tcactgctca tctgggagac      540

tcttatttat gctcctgact cagaggctgc tgctcttggg tatgactcct ctcctaagtg      600

tccttagagg tggtttccta agtctctcaa actccatcat ctcccttcag gatcagttga      660

gcctggcccc agattctgcc tcttcctctg gtgtgtggtg tgtgtgtgtg tgtgtgtgtg      720

tgtgtgtgtg tgtatgtgtg tgtgctttgt tttcttctag agacccaata tttccaaatt      780

ctgtagttcc ctttcaggca acctaaaaaa aaaaaaaaaa aaaaagggga agaggagcca      840

gtgcaacaga caggaacgtg ttcatctgtt cccgtcctca cagaactagc agctgggagc      900

cccgtgccca gccgactctc caacctgcat cggctcacgc tatcccctgg aggctatgga      960

gttggggcct cctctggtcc tgctgctggc cacagtttgg catggtaagg ggagaaaagg     1020

ggagtcctgc tgggggagtg ttgcaaagag ggcatcgctg tcctgcagta gatgcctcat     1080

tctctgcttc acttctctgg cataagagtg cagatttgtg tttatctgtc gagaagagta     1140

ggtgagagtg ggtggaacca cccggggcca gtgctgtgga tgtgtctgag cctaggcttt     1200

gactcacggt gtgctctgag tgtgaccctg gtattttcag gaccaccatc cacatctact     1260

cgtctgcagg tgggagggag ggcggtagtg ggctaacctt gagtgcagcg ctttggggtg     1320

ttacctggga gtctccttta aggcagattc ccataggtct tggtcaggac tgagattcgc     1380

atttctgagg aaatcttatg cgtcagggct gctcaatagc ttttgctgtt cttctttgag     1440

tggtcccacc agctggacag cccagcaggc tgtggttaat taggacctgg cccattcttg     1500

gaaggcttgg gtgaaaaggg tcagggtaga ggaaagaaga ggcctttttg gcccaggact     1560

caagggtgaa aagtttggac aggggtcgga ggagaacacc cgtgagtgag agatcctatg     1620

aataagcaag gaaggatgct agagaggggc ctggggaagg ccagagaggg tctccctaga     1680

cactgtcttc ctaggtctct ccccccaact tctcgggcag cagaagctgc ttcggaactc     1740

ccattcttgg aggaggtctg gctgagggtg agaacgaaca taaatggccc agtgcagcgc     1800

aaggatccca tctaggctcc agctggccta gcacacacat gttctatacc acaccactgc     1860

ttatttggaa agaccttgag ggaagatgct ggggaaggac aggctcattc tggtccctgg     1920

ggaattggtg agatgacagt ccgtggaagg ctctttgctg gctcagccga tctcactggc     1980

tcgtgcactg gcacattcct agtagaatgg gattggtatg tatgcatgag aaagcacaca     2040

ttcttaagaa tactgttaaa gggcatgtga cagatgtgtg tgtgtcaatg cagccctgac     2100

tcagctaaga aagagacaat tattattcct ctcatgccag aaaatcctgt gatttttggt     2160

tcactgcttt tcagtcttta tctcgagggc tgcttgtggg gcagagtgtg tgagtggctg     2220

catgcctgcg tgtgtgtgtg tgtgtgtgtg tgtgtctgtc tgtctgtatc cagctccaaa     2280

aggaagagaa gttgggagat atcagtggaa agcctggggt tttaacctgg aaaattattg     2340

gtgtgtgggt gggaccatgg gggcttctgt aggagctgga atagtgttga agcatttagt     2400

ggcagagaga gagaaagaga gagagagaaa gagagagaga gagagagaga gagagagaga     2460

gagagagaga gagagagaga gagagactgg cctcttctct ttgagtggta gtcatgagtg     2520

caagaggttg gggagcctcc tggagctgat ggtggaagag tccattttgc aagtacaaag     2580

aggagaaagt ttgggtcatg gggagaattc cagaagggag atgcgagatg aagaatggcc     2640

aggatcaggg catcagtggc catcaagtgc tcatccaagg gaaggtagtg atcagcgtgc     2700

ttccctcccg ccaaccctgc cagcgggaag tgagaccatc atgcggctta cgtggaattc     2760

gtcagccctg ttctgtgtaa atatccaggg caacaggcta ggcagaaata agaaggaagc     2820

ttctctcgga gcacatttcc tggaggccaa gacaggagac aaagataagc agagcagagt     2880

agcccgggag aagggagaag tgtctggaac ccaaagatgt gtcctgtgac ctttagggtt     2940

aaggtcctta gctaccacat agcaggccca agagggacat tagcagtacg gcctgagaac     3000

agcaggtggg tcaggaggac tccactgccc tctaggtggc cgctgggatt gttctcacag     3060

gacagaagaa tatctgatgc tcagagggtc aatggctatc agggtcccta gccatagtca     3120

atgtgagccc agggtgaaat agctcgtccc tcttcctgct gatcactgcc caggagagcc     3180

agagccctac atcagcagca gcacactgct ctcctctgtt ccacatctgg ctggttggag     3240

gcttgggcag acaggccaca tgtttccaaa gagtttgaat cagagtgagc agacattaaa     3300

ccaggctgaa atcatctgtg agatgagact ttccatttct gggctcgtgt gtgtgtgtgt     3360

gtgtgtgtgt gtgtgtgtgt gtgtgtgtgt gtgacccact gagagcggtt gtaggaaacc     3420

ctgaagtcct ctaagggctt gatgccctta gggctgccct gtcactgtgt aggaagggtt     3480

gacttgcggg gtcagcaaac aggacagtgg cacagcacag acagactgtg cccagtgtgc     3540

tctgaaaccc agcactcctt gccaagagtc cctcagtgtg tgagaaggac aatggccagg     3600

aggccaggga agcagaagtg agagcccaag tgtcgaaggg ccacaggctg ggcggaaacc     3660

agggccagcc gggtgccagc aatgtgtttc cgcccacaca ggccgggggc gcctgccagg     3720

ccctcagagg ctgtgaatca gttctcactt ccccccttcc cccctatttc aagcctggga     3780

aaaatgctga caccacacag gcaacgagcc tccttcccta agacctgaca gggggtttga     3840

gttctccttt cgccttcaag caaattttcc ttaaaagaga ttggctgcca agaaacccag     3900

caggctcaga gaagcgaggg cagactgggt acctcagcag actgggtacc tctctccttc     3960

atgagcatgg cattctgagc ccccaatgag tctgtactgg agcaggggat gacacaacgg     4020

tttcctggca tctgaacagc ttagcatggc ggggcaatgt gctcactgtc tgcacttgtg     4080

ggtgaaaaga caaaagggag gaggaggatg gatggtctca ggccacccca cagcgcacag     4140

acccgatgcc cagtggtagg agtgggggca gcaggagaca cttggaagat ctctttctac     4200

tgggctaaga actcatgtgt cttttttttt ttttttttct ttcccaagtg aaggaagatg     4260

gcccaggact tggccatctg tttctccatt ggcttatttg aaacatgtct tacttaaaca     4320

ggcttggcct gcttagtaca cgagattgat ggtgccctct cctgggatgg gaaacgatgc     4380

caaaggctgg gcctccgtgg ctttgtggag aagcctacat gtgtggctaa ggaggcgccc     4440

acgtaggtct cagggatgag cctcctgaga gtggcagatg tcaatagagt tggaagctga     4500

ttgaagggtc cagactcatt ccagaaccag agccagagct atcccttcca aagcatggtc     4560

cagtgttggg ggacatctgg ggtgcacccc aggcctcact tgtgtctgcc acctccttca     4620

ggtcagggg                                                             4629


<210>  37
<211>  4516
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  3' arm

<400>  37
ctgtccttgg agaaacacaa aacccttcct catacggaac taaaagctgt ctctggtgcc       60

ccataagcac caggatctca gagctctttc tgccttgact gacaggcctc acctcatggt      120

ggtctaaggc acctcagctc tctctacaac accattttct gaatatatca ccctgggtac      180

cgtctcattt cccatccagg aaacttacct gcttcttatg tagcccaaag ccaggggacc      240

tgcagcctca ggctggcctt ttctccttca cccttggatg tccattgact gagttgctcc      300

tgaaagaaag acctgaaaga ggcagtctag ttagcagctc tcttctggcc aacctctttg      360

taggtagggg acttggcccc acctgtcttt atccccaggt ctgagtgaga catggcctgt      420

ctatggaagg gttgtttctg ctaagggctg agttgagtca tccccttctg tcccccagag      480

aaaccacaac agtggggaag gcacagggga agaggaaagg acccgagtca gctggcccca      540

gggataggga aaaggtaggg aggatgatgg gtagagagaa gggaagggta gactcagaaa      600

gaaaccactg aacagatttt gggcccaggc ctaaattgaa ggaggagggt ctggagagct      660

tccaggagaa atgcccaggt ctttaccatc cccaggctca atacctaccc cacagaccaa      720

gggcctgatg gggagggtgg ccaaggtctg atgttcccaa gccctcttca atctctgtca      780

aggaatcagt ggagagcctc aacttagagc tagcatgagc aaccagtgaa ttgatctgca      840

gtgaggattt agctaggccc agctcccaag aaagcaaagc attccagtca tccctccttc      900

taggaaggga cctcacaggc cactctacct tcacaaggac aggaccccag agtcaccggg      960

gacggaaaga attcttgagg ttggcagggc ctccgtgctc aaatcatgga ttcggccatg     1020

ggagcttcca gctgaacctc ccttccccct cagaccatcc cttccaacat tgtcctagca     1080

gaggtgggag ggctgagtca gcccagctgc agaggaacaa gggaagcaga agtggctaga     1140

aggaaaacag ttgcagccac agagactcct ggagatggaa gatggaagtg acgggagggg     1200

tcacccagcc ggagggagtt cctctccaga gctcacttca gccactttgc ccaagccata     1260

acatacactt actttattgt tgctgttact agaagtggtg ttttgtgttt gtttgtttgg     1320

ttggttggtt ggttggtttt gttttgtttt gttttgggga ctgggtctcc tatagctttg     1380

aggatggcct caaactccct ctgtagctaa ggctggccat agacacccga tcttcctgct     1440

tccatctccc aaggatgcca gtgtgtgtct tcatgcccac tgggtgtcct tccttatgtc     1500

taactacagt cttctctctt aaagctccag ctggaaggtc ttccttgtag ctacataaac     1560

tctcctctgc ctgtaagact tcagcaatag gctacctcct ccccaacact aactcatgca     1620

tcctttagct cttcttgcta agcacccttg aaggaaggac cttggttgct ggacacagcc     1680

cagtccctgt ccccaaggcc tgactgaaca caagttggtc aggggactga aagtcttggt     1740

gtcctccacc accccagcct agctttcact gtcccatata tgtggccttc cctcagttct     1800

tctcagggca gctcttggca tgatgccctc atgcagttgc ccctggggca gggaaaggtg     1860

aagtactcac tccctctgct actgagaacc tgagagggaa ctggagacag cagaatgtgt     1920

gatatgcagg gcaccccctt tgtgggaggg cacttcctca gcacctttcc ttcttcctag     1980

agttaggaga cagcccctgt cttagaggct tcctgacctt cctgcctgga ggctcccctc     2040

tatttactaa gtcacatggt cacctaccta tttcccgagt ttgtcaggat cgtacccatc     2100

tcaaggctgc ccagcatctg tgggctctat gcctggaaca cttacttctg cctcctcagg     2160

gactctctta taccattctc tgccctgtca ccctgcttcg taggcttcat gaccttattt     2220

tttttttcaa atgttttaaa acatttgttt ctggggctgg gaatatgact cagaggttaa     2280

gagcactgac tgctcttcta gaggacccag gctcaatttc cagcaaccac aggttgattc     2340

aaaatgatct gtaagcccag ttctagggga tccaaccttc tcttctgacc ccgttggata     2400

acaggcatgc atgtggtgcg acagttatac atgcaggaaa aacacccata tacataaaat     2460

aataaaaaat taaaatagca tttgttagta tgtattgatt atatactata ctataatata     2520

taatgatgaa tttcttgtga catcttcaaa catgtaccta atgtatattg atgatattgt     2580

tcacattcac ctcccattac cctcgtcccc cgctcatatc tgctgttccc ctttctgtcc     2640

ccaaactcct ctttcacttt aatttgtgta tgtgtgtgtg aatatgtgtg tgcttgctcg     2700

caggtgtatg tatgtatgta tgtatgtatg tatgtatgta tgtgtatata tttgtgtgtt     2760

tgtgtgcttg tatgtatgca tgcatatgtt ctaatatcta tcattagggt tgcttgcaga     2820

agtgtaggtg agttatttat agagattaag ctatacaatt gaagaaaaca tctctcccac     2880

caccagtaat cactaactgc ctgcagatat tcagggtggg gagcacttgt gagcctctcc     2940

ctcctccacg acgggatgtt gataagactg atcctgtcag gatcttaggc aggtacccac     3000

agctgctgtg agttcagcgc agcaggcaca tcacgcccgg ctgacagtag tgcctaaccc     3060

tccagacgat gccagctctt gtattctttt ctatggtgtc ccctgagccc cagagcgatg     3120

cagctggctg tctcctttat ggcccagtgt tcactggtcg ctcactctca gcactttgtc     3180

agtcatgagt ctctgcagtt actgctgaca gttgcaaaca gcagcttctc caaggaaagc     3240

cgagaacagc actatctatg gggacaggca gacttattta gaaagttagt tgacaggcac     3300

tactgtatcc atttagcaaa acagcagctg gacagtcccc actaaggcta gtaccctccc     3360

tagccaggag cttttgacca aaattacagt accagatgtg gcttcaacct gtagcctcaa     3420

tgtcaatcag aaagcataca gacactccaa tagcagaccc gactttattt gcacgtcttt     3480

tgaggcatta tctgactgtt ccctatttat ttatttaagt tgaatgtctc ttttagccat     3540

tcaaatgcca gccccacagg gccaatcaag gagttgatca tgcatgatga tagaaataca     3600

tgctcaagag gcaggcagat ttctgagttc gaggtcagcc tggtctacag agtaagttcc     3660

aggacagcca aggctacaca gagaaaaacc ctgtctcgaa aaaacaaaaa caaacaaaca     3720

aaaaaaaaaa aagaaagaaa gaaatacgtg ctcagtaaaa tgtctgggag gctgtattgt     3780

tcagcctgga gaagagagca aagtttgact tcagtgtagt tgagatgatg agatgatgct     3840

cagcgaaagg aggcggtccc aaaagatgtc acgtgactgt tgatacgaaa tactcagaac     3900

agtaaaataa attcatgcct tccagtggct agaaagagcg gggggagggg ggagtagggg     3960

agtgctctcc actggccaca gcagagcttg tttctacaag gtcagaagag ttctagatat     4020

tggtttccta tcattactaa taaactcaat accaccgagg tatatgcttg aaatgtttgg     4080

gatggtacat tatctgtttt gtatacttca ctagaattga aaaagaaagc agggctggag     4140

aatagcttag ttgtatagta tgttcttaca catatataag atcctggccc aatccctagc     4200

acccaaaaca gaaatgggaa cataaactct ttgggtgagc aagtggacag gtccatgaat     4260

aatgagtgga tagttctcaa cttctaccct cctccacctt ggcccaggaa atgtcaaata     4320

cagagtcatc aagggagaac tttgggaatc atctgagtct ttgagtgaac agttttaaat     4380

gagtctgagc cttgacgaag gagggaaggt cacatagtaa aggcagaatc aagcacagac     4440

tagttttgga tgctctgtcc acaagatgcc atggtccctc tcagcacata gtaggctgac     4500

aagcttctgg attgtc                                                     4516


<210>  38
<211>  12727
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  nucleotide sequence of 150068290-150081016 of NCBI accession 
       number NC_000005.10

<400>  38
atcccagtga tagagcccag tgtccctgag ctggtcgtga agccaggagc aacggtgacc       60

ttgcgatgtg tgggcaatgg cagcgtggaa tgggatggcc ccccatcacc tcactggacc      120

ctgtactctg atggctccag cagcatcctc agcaccaaca acgctacctt ccaaaacacg      180

gggacctatc gctgcactga gcctggagac cccctgggag gcagcgccgc catccacctc      240

tatgtcaaag gtgaggagtc tgagcctcct cccaagaggc ctgacccggc aggccccact      300

acaatgggcc ctaaaattaa caatcgtaac aattcagctc tgcatttact gagtgctggc      360

tatgagcaag gacctggaag agctgctaat gtaatgcagt cctcacaaca accctgcaag      420

tcgggtctat gatgatgcat tttctagaag tgcagggagg ttatccaagg tcacacagcc      480

tcacatagtg ggactagact ggagcccagg tgcgcctgac tctggagcca ccacgctgaa      540

gcatccgctg aactgtcctg gcgtggtgtg acctcagatg aatgatcagc ctctctgagc      600

ttccttgtca cctatgtcca ggtactcctt ggcccagtgg agggagggca gttgtaaccc      660

tgtgccctcc tctactctag accctgcccg gccctggaac gtgctagcac aggaggtggt      720

cgtgttcgag gaccaggacg cactactgcc ctgtctgctc acagacccgg tgctggaagc      780

aggcgtctcg ctggtgcgtg tgcgtggccg gcccctcatg cgccacacca actactcctt      840

ctcgccctgg catggcttca ccatccacag ggccaagttc attcagagcc aggactatca      900

atgcagtgcc ctgatgggtg gcaggaaggt gatgtccatc agcatccggc tgaaagtgca      960

gaaaggtgcg tggggcatgg ggaccggcag ccaggcctga agagtgggga cagagagccg     1020

gcggccacat gggtggtgac tggggactgg gtgtgatggg gggcagtggg atgtcctctt     1080

tctttcactt cttcccctca atggttccac gatcatctat ggggcaggac tgacaaggtg     1140

tcggggcagg gagacaaacc acatgtgagc aaataactca gtgggcaagg tcatctcaag     1200

tcattggaca tgctacaaaa ataaacattc aacatggtag ctgaataagg agtgtgtagg     1260

gcggggagcc tcactgagaa ggaaacactt tattagagcg gaaatctgaa tgacatgaag     1320

aaggtggctg tgcaaagatc tgcttcagca gggggacagt gagtaccaag tggtgaggtg     1380

gggacaggct ctgaatgttc taggtatgga aagaggacgg aagctcagcc tcagacatgg     1440

atttcccact gggggcctgc ctaaggccaa gtgctgggca tgtgtaggag ggatgctgag     1500

ccaagaggca gggaggagat ggtgggtgcg tgtgatggct ctcgcggtgg ccaggtaaca     1560

gtggaggtgg agtctcaccc tgctgggatg gcaggcagga ttctggtttc tgggaggact     1620

ggtgagagca agcaggaccc cagcctgagg acctgggctt gagacagcaa tcagtccctg     1680

taacaagggc cagggtcaga gtgaagcagc tagcccaatg ccactgggat ctgaagccac     1740

taaacctgcc cagggggtca aaggacccca gctgtgtggg cagaggaggc cattagggct     1800

ctttcctggc atttcatcct gcagagccct gggctggcca agagccaaag gtcctgggcc     1860

ctagttctgc cttgacaccc cctcagggac cttgggtgag tcctttcatg tccctgggcc     1920

ttaggaatct ggattagatt atctttcaac agcagcaatg ggcataaata tgaattcaag     1980

gcctactgtg catcaggcat cttgctggct gctggaatat tcctgtcacg gatttgacat     2040

tcgactagag tctaactatt aaatagaaag taaatacaaa tgtgatgagc aagaaaccaa     2100

gctggggagt ggcgggcatg gaggtgctgg ggaggctaat tcatatcagc tggtcacaga     2160

agccttgctg aggaattttt gagctaaaga tctgaaggat gagaacagcc tcccatttga     2220

agtgtgggag gaaaggcatt ccaggaggga aaggtgggtg caaaggccct gtggtaggaa     2280

agaggtccag cgggctgcag tgcagtgaac aaggggtggg gttatcaggg cggtcagaaa     2340

caggttgggc tgtggaagga ctttgacttc ttttctgaga gtaatgggaa gccccaaatg     2400

tttacagagg agagaggcat ggtcccattt atatttgtaa gaggtcactt tagtgaagaa     2460

tctaggtgtg gggggcttgg agggaggcag ggaggtctct gaggaggctg gtgcagaagt     2520

ccagagtgga gaatggtgac gggactgggg aggggtagag gtgatggaga aagtagactt     2580

tccaaggtct ctttaggaca ggccttgcag tggggggact gggagcatca aggctgcctc     2640

ccaggatttg ggatggggca gtgatgggga ccctggcctg tgtgtcctgg cccatggcag     2700

ggaggagagc aatatctcta tcatgttcag ggagcctggg tgttcagggg tctctccccc     2760

ggtctcagtc atcccagggc ccccagcctt gacactggtg cctgcagagc tggtgcggat     2820

tcgaggggag gctgcccaga tcgtgtgctc agccagcagc gttgatgtta actttgatgt     2880

cttcctccaa cacaacaaca ccaaggtcag tccctgcaga tcacaaggtg aagtctggcc     2940

atcctcccag cacaccaggt ttcccatggt ggagtcctgg gcccccaact ccaaactggc     3000

tgtcttagct gaaggcacag ctcagactcc agagaggggt gcagactcac ccgagatctc     3060

actcccagtc agtagctgac acagaatcag gactcatgct tgtgccgctg aactttgtgg     3120

gggtgggtgg ggggaggtgg ttctctgtca ccttgacaca tggcctttgc cccagccttt     3180

agacaaaagc cagaggtgag ctcacttctg atttagcaag ggtttcctag gccaccattg     3240

aagcccagga atataacagc tatttcagaa agacattggg agagagggag gaggagggag     3300

gattccagga gggactcacg ttgggctgcc tctaagagcc ccctcccttc ccactgcacc     3360

tgccgtgttc cagacacagc cctaagccac ttgcatgcat atctcattta ctcctcacta     3420

cagtcttggg gcagggagcc agtattagcc ccattttaca agtgaagcaa caggctcaga     3480

ggaaaggcag atagtaatcc ttaaaggctg aggattggaa cccagatctt tctaatccct     3540

aaactacctt ggtataacat ctccattcct tctggctgca gctcgcaatc cctcaacaat     3600

ctgactttca taataaccgt taccaaaaag tcctgaccct caacctcgat caagtagatt     3660

tccaacatgc cggcaactac tcctgcgtgg ccagcaacgt gcagggcaag cactccacct     3720

ccatgttctt ccgggtggta ggtaagcatc agggtggtgg tggacagtcg gtagggatcc     3780

tgcaggagtg tgagcagaag ggttttgagg aggaagctga tgtcagggaa ggagacctgc     3840

tgaggatatc tctgctggag tttgtttatc caaggcctgg ctaaggagcc actctccagg     3900

agctttccct taccctctcc tgggatctct ctcccatctt ggagctctta cagtgcatgg     3960

ctgcattggg tgcaccttag tgccattttt tgtttatttg gggattgggg tccagtagct     4020

ccctactgga cttcatttgt tcattctttc atgcattcct ttatggaaac atgaaaagac     4080

aatgatcacc cagtgattat gggggaagca caaggtgtcc tgggaacact gaagagtccc     4140

cccaacccag gcttcgagaa ggtggcctct aaactgggat gggaagaatg aaggtgagtt     4200

ggccgggcag aagggtggga aaggaagggg aacagcgctt ctggcagagg gaggaacata     4260

tgcaaggctc aaaggcaaag agaacataga tcatttggaa cactgaaaga acttgacaac     4320

agctgggatg tggagtggtg tgaggagtgg ccacagggga gcagaggagg tggcagaagc     4380

cggaggtaaa ggtgtcttaa agtgagaaag aataactgca tcttaaccta ttgggaggtc     4440

attgtaaaga ggagagtgat ggggtcagat tgtacagagg aggcacttcg tggtggtcag     4500

gagcacacac tccagggcag tgttccaacc tgagtctgcc aaggactagc aggttgctaa     4560

ccaccctgtg tctcagtttt cctacctgta aaatgaagat attaacagta actgccttca     4620

tagatagaag atagatagat tagatagata gatagataga tagatagata gatagataga     4680

tagatagata gataggaagt acttagaaca gggtctgaca caggaaatgc tgtccaagtg     4740

tgcaccagga gatagtatct gagaaggctc agtctggcac catgtgggtt gggtgggaac     4800

ctggaggctg gagaatgggc tgaagatggc cagtggtgtg tggaagagtc tgagatgcag     4860

ggatgaggaa gagaaaggag ataaggatga cctccaggtc tctggctatg gtgattgggt     4920

gcaggcagtg gcagtcactg gactcagacc ctgaagcaag gcagcagctc atcggagtgg     4980

gagcaggctc tgagacattt aggtctggcc gtgcctcatg tgttgaatgt tatgggagat     5040

ggaggtggcg aggagcatga gaatcatgag catcactgcc cctagagtat gtgcaaggca     5100

ctggacttgc agcagattgt gagctctgct gtggacccca atctgcactg ggagctttgg     5160

cagggtaaag gggaagaaga gcaaaagcac aagaattcag ttacggcttc taatcctgtc     5220

tgctttctag tacaggcata cagtcatcac tcaagaaatg tttatgttca ttcacacttt     5280

gggccagaca ctgttctaga catcgaggat acagctgcaa gtgaaacaga tacaacaacc     5340

cccgactcat gaagtgtgtg ctctagctgg gagtgggcaa gcaatgagcc aagtaaatta     5400

ttaaaaaaac aaattatata gcatttgcag cttcagatag ggtgttcacc aaggaagatc     5460

tcactagaaa gctgatattt gagcaaaggc ttaaattgct gaaggagcaa gccatgcggc     5520

cattttggag aagggagctc catcctgcag cgggactgtg cttgccatgt tcaggggaca     5580

agtgggccag tgtggctgcg gggagagagt gagaaaaaaa gtggtctcag atgaggtcag     5640

agagctaaag tgggaaggtg agatgaaagg aggctaccgc agtggtccag gctggagctg     5700

atggtgggtg gactagagtg gtaatggtga aggcagcagg aagttgttgg tgtttggatg     5760

gatgaatgga ctaatggatg gatgaataat agatagatgg attgttgaga gagacagaga     5820

agagaaaagc cttgccccca aaagctcaca gactacttgg agagagaaga aagctacctg     5880

gagggagaac cagatgcatg aagcagtgca gatgtggtgc ctaatgagtg tgtagtctgg     5940

aagggcagca aaagtcgagt ggagtgagag gttcctgtgt cctggagcac tgagtagaga     6000

ctccctcatg ggggtgaatc ttaaaggata aaggggcctc tataatgaaa aggaggagga     6060

tgggatttct ggtagaggaa attgcttgag caaaacctcc aaggttggaa tgactatggt     6120

gtgttcaggg atgttaggag acccagatgg gtggagcgtt gagtgtgtgt gtgtaggaag     6180

gaagagggga ggtggctgga tgagcacagt gagacctgat ttgattgaga gccttgaacg     6240

ccacgctgaa taatggaggc aatgggactc catagagggc ttttgagtag acatatatca     6300

gtgtagaagg gtgaatttca gatttttaga cagaatagag taaggagagg agctcttaga     6360

aatcatctag tccagggctt gtggcagagc cctgaggttt taagaaggca tgtcaggggc     6420

taccatgaca ggcacggaga ggctgagtga attggggttc ttgccacaat tcccttgcct     6480

gagattcaac aagagcagct gtattacaat ctgtgcaaaa tgtcattagg agaaactagt     6540

tagtagctgg gcgtggtggc atgcaactgt tgtcccagct actcgggagg ctgaggccgg     6600

agaatcgctt gaacctggga ggcggaggtt gcagtgagca gagactgtgc cactgcactc     6660

cagcctggat gacagagcaa gactctgttt caaaaaaaaa aaaaaaaaaa actagtcagg     6720

actctttcag atacaagtaa tagaaaccaa ctcaaactgg cctaattaaa aggatttttt     6780

tccttatagc taaaaagctc atggatatca gcttcaggaa cacttggatc caggtgttca     6840

gctgatgctg gaaagaatct atgactcccc aactctcagc cctgccagga aggctttccc     6900

cttgtaggac tccgactatc cgccttgtag tatctgatcc agcaacacca gtaaaatgag     6960

ggcttctctt ttcccagagt cttaacaaaa atcatggaat tgagtgttat ggactcatgg     7020

attcatggta acccaaacca atcaccgggc cagaggggac agagtaccct cactggttgg     7080

cctgggttac acacctactc cagagctata tttggaagcc gcattgacta atttatgacc     7140

agaagaaagg gaaatggatg aggacacgtg aaattgtgtg tgtatgtgtg tgtgtgtttt     7200

cttgctgcca aaaatttttc aaaaacttgg aaaatcacag atatattcaa tctcttcatt     7260

acacaaataa ggagatggag gcacaaatgg ggatagggat ttgcccaggt tctcctaggg     7320

cttcagtgag aaaagttttg atccagggat tctgaagggg gtggtgagaa gaggggtgtc     7380

agaggacctg tcttgggtgg tggggactat gtacctgtga catagctgct cagggactgg     7440

atcaatgggt ggatgacaaa atggacaaat aaacaaggac atcttcccac taatgccaga     7500

tgcttgtgtg ttctgctttc cagagagtgc ctacttgaac ttgagctctg agcagaacct     7560

catccaggag gtgaccgtgg gggaggggct caacctcaaa gtcatggtgg aggcctaccc     7620

aggcctgcaa ggttttaact ggacctacct gggacccttt tctgaccacc agcctgagcc     7680

caagcttgct aatgctacca ccaaggacac atacaggtac cacttatcag ctcccgtcta     7740

cacagcccga caaccagatg gggtatgctt cagcaagcat caggacgctt ggctcatgtc     7800

ccaaccttgg tgtatgacct tgagcaagtc cctgcccctt tctgggcttc gctttccctg     7860

acttcatgga atcccaatat tggtcatctg tgtttgagat ctagatgaaa ttgacctacc     7920

tctccatccc acatccttgg gatagtcaat gccccaccca aggattctac catttcttgg     7980

gagtgtgcat tctcattggt ccctcaagaa ccctcagcct cattcatttt cctctcttgg     8040

ggccaatcca aatgcagaaa acagccccac tcatagacac actcctgata atgactgcac     8100

aagttatctg ctacatacaa aagcttggag ggaggggaag agggaattaa gatcacacaa     8160

tcacagatac atgaaatgtt ctttaaagga ttgtgatcac ccagccccaa gaatttctca     8220

ctggctgctc ttctctgtaa gctcaaaact cttcccatga agtgcaatct ataataactc     8280

cacacccctc ttcttccgtc tctccactcc cacaatcctg tgtattccac acacatttta     8340

gaaatctttt tcctgtctgc ttgtgaactg tgttcttggg gtcttgcttt ctcatccaaa     8400

gtggcttaag caggtaggtt ctaaataaga aagctttgtg cctaagagga acactcatac     8460

caggtatatc aggtattaac tcaggtatta aaatagttcc ttcttttctt tctttttatt     8520

atttttttta gatggagttt tgctcttgtt gctggagtgc aatggcacaa tctcggctca     8580

ctgcaaactc ggcctcccgg gttcaagtga ttctcctgcc tcagcctccc gagtagctgg     8640

gattacagat gcccaccacc acacccagct aatttttgta tttttagtag agacagagtt     8700

tcaccatgtt ggccaggctg gtctcgaact cctgacctca ggtgatctgc ctgcctcggc     8760

ctcccaaggt gctaggatta caggtgtgag ccatcgtgcc tggcctgaaa taatcattca     8820

taccctgccc tttcagaggg agacagtaca gcttaagggc agcgaatacg tggtgtgcat     8880

gccacactca ctctcattct tgtttctgca actctgttct gcagagtgta gatgcggcct     8940

cagagtcctc ctcaacacag gtcccaggca gtatttccag catagttggc tcatgagaga     9000

tctgtttgtc atccctgtgt ggatccctta gacaacttca aaactctttg ggattctcgt     9060

tctagctctg gaagcccaaa cctcattgat tcccacaatc ttgcttgtca attgtcagaa     9120

gcaacaagga tgttttcttg tcctcatctt cctcctctca gttcccttct ggtcctttct     9180

ggccaggtct ctgtcttcct ctcatttaaa gcagaagttc tgaatctgga atgtgtaggc     9240

cctttggagg gggctggtcc atggatcggt ttaatgggtc cataagccac agagacattg     9300

aggaaaggaa cacgagatcc cctaaaacac agtagtctgg gcccattcag cacaaggcag     9360

acaagcctgg acaccaaaca gccacagaat tttagttcat gtgatgggtt gttcataatg     9420

gtgactttca attatccaaa aaagtcaaat tatttttagt taaaggggtt agttatctca     9480

agaagtgacc tgggcagagg ccttgtatat gcccagggtc tggctggatg agactgctct     9540

ctgaatacca tagattttag tctagtagta gctgcagaca tttcccaagc aagaactggc     9600

catttgctat aatttttaaa attttattta ttttgacagt gaactggggg actttttaaa     9660

aaatgtattt attacctaaa caacacatgt tcattatgga caaattgtaa aatagagatt     9720

aaagaaagaa taaaacaaaa aatttcccag aatcagccaa agatgatttt tattgttagt     9780

ttttgctcca gggccttttc tgtaataaag ggtaccattg aattgagtgc ccacaaagat     9840

tcaacttctg tgtcaagcac cctaaaaagg tcctttaatc ctcaagccaa gcctgtgaat     9900

taataaccat cgatatcact ctcacagcaa aggaagtgag ggatcagaga ggttaagtac     9960

ttgtctaaga tcacacagcc aagaaacagc agcaccagga cttgaacccc agtctctgca    10020

gcaacatggc tcagaaccca gggccctaca tcctgcctct tgtctctttc tcagtccctc    10080

ttggcaaggt tggcacttca gggatttgta gcagggattg cagctttcat gaaagcttag    10140

tccagtgaca gtggtcaacg taggcgacct gtgataggcc tcccagcacc ttgaagacat    10200

cacctctatt aaacctcggg aaaaaaacac tttcagataa gaaaaccaac taaggaaatg    10260

ggattggtgg tttttgcatg tctcaatggc accctgtctg agtatctggc ttacccaagg    10320

ccgttgggcc ctgaatattt taccaaaaat aaaataaacc cctttaaggc tgttatctga    10380

ctgcaatcct ggcaggggcc atactaggct ggggctcacc aacaccacct gattctctcc    10440

tgcaggcaca ccttcaccct ctctctgccc cgcctgaagc cctctgaggc tggccgctac    10500

tccttcctgg ccagaaaccc aggaggctgg agagctctga cgtttgagct cacccttcga    10560

tgtgagtgct ggggccgagc gccacctggg gcggaggccc tgggactgcc tggagggatg    10620

gggttgactg gggcagggca cagggaagta ggtactggga gattgggagg tggcggggaa    10680

agtgtgactt ggggcctcct cctttcttcc tcagaccccc cagaggtaag cgtcatatgg    10740

acattcatca acggctctgg cacccttttg tgtgctgcct ctgggtaccc ccagcccaac    10800

gtgacatggc tgcagtgcag tggccacact gataggtaag tgggctccac tcacctccct    10860

cacctgggct caggggctgg gcaccctgtg agtgggaggg acatgctggc gctgggaacc    10920

ctgaagctct gagccacatt ctgcttttgc caggtgtgat gaggcccaag tgctgcaggt    10980

ctgggatgac ccataccctg aggtcctgag ccaggagccc ttccacaagg tgacggtgca    11040

gagcctgctg actgttgaga ccttagagca caaccaaacc tacgagtgca gggcccacaa    11100

cagcgtgggg agtggctcct gggccttcat acccatctct gcaggtgaga gggagccttc    11160

gcacccgcac cgcccccccg cccgcccccc gcccctgctc ctttaggcgg ctcctccccc    11220

accccccacc gagggagctg gggttggctc cacctttgga gcagatccta gcagtaccaa    11280

ggtccacctc tctgggccag tccaagcccc tcctgcctgg caggtccccc gaagcagtag    11340

gacggggtag tctctgagaa agcagagaga aagcagcctg aagaaactgg cccccactct    11400

tgtccctgca ctctaactca tgcatctatt cacaagtatg tgcaggcatt atgcaccgtg    11460

tgccagggac gtgccctatg cagggaagca gtgcctcccc agagctcaga ggctgatgag    11520

ggaggcaggc aatgagcaag gaaacagtcc atctccagct cggggccagc taaggacggc    11580

cttctccaac tctcccctct tgctccagac acagtctatc catttgaggt tgctgtgcaa    11640

gaggctgccc cgggggatga tgcccggccc tgtgcacaac acaggctgcc tctctgcttt    11700

acacaaaggc tccttaccag ctagttctgt gattctcaga ggcccacagc atcctcaggc    11760

ttttgacaac caggctctgg cacccactgt gtgccagacc ctggcatctg cctggctcag    11820

gggtggtcac tcacgtcccc agctgctggc cttggagcaa ctgctaccag ggtccagctg    11880

caagcaggag cctgcggccg cgctgggcct cactgctgga ggttgtatat tataataaag    11940

ccaacatttt gttgaaggct tctgctgcgc caggcactgt gttaagctct ttgtggggat    12000

tatctcgatt aactcctaca aacctaggaa ataaatagaa ttttccctag gctcaatgtc    12060

acacagctcc caagtggcac aggtgaaact tgactgcaga tctaagttac tgatctgagc    12120

aaggaagtgg aaattatgtt ctccaaaaca tcactagaac tagtagtata gattctggga    12180

agaggagact caggggccac aagcctggct tgctagaccc tcagaagggc tgtatgattc    12240

caaaggcatg tggagaagct gcaggggaaa tgcaggagag gaaggttgca gtgtgacctc    12300

cagaaggcct ttctgaacga gcttcctgga ggtgtagtgc atgcaagcca tggctgggca    12360

ccaggccagg ccgctgcaga gaggtttctt gcactggcag agggtgagac tgcatgaccc    12420

cagaggctcc ctacccccag ccacaggagg ctgtgactct ggacagggtt tggggctggg    12480

catgagcaga gctgaagagg ccgtcctctc tgcctttctc ggggagggtg tgcaggagag    12540

gctccagagg cttccagtgg aggatgcttc attcagtcaa caagcattta ttgagcaccc    12600

actgtgttcc aggcagtgtg caggcctgac ctcagggggc tcggaggcac ccctgcctgc    12660

tcactgcttt gcttcatgcc ttccaggagc ccacacgcat cccccggatg agttcctctt    12720

cacacca                                                              12727


<210>  39
<211>  80
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  connection between the 3' end of the human CSF1R DNA fragment in 
       the A fragment and the mouse CSF1R gene

<400>  39
agcccacacg catcccccgg atgagttcct cttcacacca gtggtggtgg cctgtatgtc       60

tgtcatgtct ctgctggtgc                                                   80


<210>  40
<211>  100
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  connection between the 5' end of the Neo cassette and the mouse 
       sequence

<400>  40
ctggttgcta cttaaccact cagacatagc ttagtcacta ccgtgactac gaattccgaa       60

gttcctattc tctagaaagt ataggaactt caggtctgaa                            100


<210>  41
<211>  100
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  connection between the 3' end of the Neo cassette and the mouse 
       sequence

<400>  41
gaaagtatag gaacttcatc agtcaggtac ataatggtgg atccaatatt ctgtccttgg       60

agaaacacaa aacccttcct catacggaac taaaagctgt                            100


<210>  42
<211>  3881
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  mRNA sequence of the engineered mouse CSF1R after humanization

<400>  42
gggtatgact cctctcctaa gtgtccttag aggtggtttc ctaagtctct caaactccat       60

catctccctt caggatcagt tgagcctggc cccagattct gcctcttcct ctgttccctt      120

tcaggcaacc taaaaaaaaa aaaaaaaaaa aaggggaaga ggagccagtg caacagacag      180

gaacgtgttc atctgttccc gtcctcacag aactagcagc tgggagcccc gtgcccagcc      240

gactctccaa cctgcatcgg ctcacgctat cccctggagg ctatggagtt ggggcctcct      300

ctggtcctgc tgctggccac agtttggcat ggtcagggga tcccagtgat agagcccagt      360

gtccctgagc tggtcgtgaa gccaggagca acggtgacct tgcgatgtgt gggcaatggc      420

agcgtggaat gggatggccc cccatcacct cactggaccc tgtactctga tggctccagc      480

agcatcctca gcaccaacaa cgctaccttc caaaacacgg ggacctatcg ctgcactgag      540

cctggagacc ccctgggagg cagcgccgcc atccacctct atgtcaaaga ccctgcccgg      600

ccctggaacg tgctagcaca ggaggtggtc gtgttcgagg accaggacgc actactgccc      660

tgtctgctca cagacccggt gctggaagca ggcgtctcgc tggtgcgtgt gcgtggccgg      720

cccctcatgc gccacaccaa ctactccttc tcgccctggc atggcttcac catccacagg      780

gccaagttca ttcagagcca ggactatcaa tgcagtgccc tgatgggtgg caggaaggtg      840

atgtccatca gcatccggct gaaagtgcag aaagtcatcc cagggccccc agccttgaca      900

ctggtgcctg cagagctggt gcggattcga ggggaggctg cccagatcgt gtgctcagcc      960

agcagcgttg atgttaactt tgatgtcttc ctccaacaca acaacaccaa gctcgcaatc     1020

cctcaacaat ctgactttca taataaccgt taccaaaaag tcctgaccct caacctcgat     1080

caagtagatt tccaacatgc cggcaactac tcctgcgtgg ccagcaacgt gcagggcaag     1140

cactccacct ccatgttctt ccgggtggta gagagtgcct acttgaactt gagctctgag     1200

cagaacctca tccaggaggt gaccgtgggg gaggggctca acctcaaagt catggtggag     1260

gcctacccag gcctgcaagg ttttaactgg acctacctgg gacccttttc tgaccaccag     1320

cctgagccca agcttgctaa tgctaccacc aaggacacat acaggcacac cttcaccctc     1380

tctctgcccc gcctgaagcc ctctgaggct ggccgctact ccttcctggc cagaaaccca     1440

ggaggctgga gagctctgac gtttgagctc acccttcgat accccccaga ggtaagcgtc     1500

atatggacat tcatcaacgg ctctggcacc cttttgtgtg ctgcctctgg gtacccccag     1560

cccaacgtga catggctgca gtgcagtggc cacactgata ggtgtgatga ggcccaagtg     1620

ctgcaggtct gggatgaccc ataccctgag gtcctgagcc aggagccctt ccacaaggtg     1680

acggtgcaga gcctgctgac tgttgagacc ttagagcaca accaaaccta cgagtgcagg     1740

gcccacaaca gcgtggggag tggctcctgg gccttcatac ccatctctgc aggagcccac     1800

acgcatcccc cggatgagtt cctcttcaca ccagtggtgg tggcctgtat gtctgtcatg     1860

tctctgctgg tgctactgct gttgctgctc ttgtacaagt acaagcagaa gccgaagtac     1920

caggtgcgct ggaagatcat cgagagatac gaaggcaata gctacacctt cattgaccct     1980

actcagttgc cctacaatga gaagtgggag ttccctcgga acaacctgca gtttggtaag     2040

actctaggag ccggtgcctt tgggaaggtg gtggaggcta cagcctttgg tctgggcaaa     2100

gaagatgcag tgctgaaggt ggctgtgaag atgctaaagt ccacggctca tgctgatgag     2160

aaggaggccc tgatgtcaga gctgaagatc atgagtcacc tgggacagca cgagaatata     2220

gtcaacctct tgggagcctg tactcacgga ggacctgtcc tggtcatcac tgaatactgc     2280

tgctatggag acctactcaa ctttctccga aggaaggccg aggctatgct aggacccagc     2340

ctgagtcctg gtcaggactc cgagggagac tccagctaca agaacatcca cctggagaag     2400

aaatatgtgc gcagggacag tggcttctcc agtcagggtg tagacaccta cgtggagatg     2460

aggcctgtct cgacttcttc aagtgactcc ttctttaagc aagatctgga caaagaggcc     2520

agccggcccc tggagctctg ggacctgctc cacttctcca gccaagtggc tcagggcatg     2580

gccttccttg cttctaaaaa ctgcatccac cgggacgtag cagctcgaaa cgtgctgttg     2640

accagcggac atgtggccaa gattggggac tttggactgg ctagggacat catgaatgac     2700

tccaactatg ttgtcaaggg caatgcccgc ctgcctgtaa agtggatggc cccagagagc     2760

atctttgact gcgtctacac agttcagagt gatgtgtggt cctacggcat cctcctctgg     2820

gagatcttct cgcttggtct gaacccctac cccggcatcc tagtgaacaa caagttctac     2880

aaactggtga aggatggata ccaaatggcc cagcctgtat ttgcaccgaa gaacatatac     2940

agcatcatgc agtcctgctg ggacctggag cctaccagaa gacccacctt ccaacagatc     3000

tgcttcctcc tccaggagca ggcccgactg gagaggagag accaggacta tgctaacctg     3060

ccaagcagcg gtggcagcag cggcagtgac agtggtggtg gcagcagcgg tggcagcagc     3120

agtgagccag aagaggagag ctccagtgaa cacctggcct gctgtgagcc aggggacatc     3180

gcccagcccc tgctgcagcc taacaactac cagttctgct gaagtgggag ggagagccga     3240

gtcctgccgc tctctacgtc ccagcttggc ctcctccatg gcacgggcga catggggaga     3300

acatatggac ttcgccctca gcttggccca gctctgacac ttcagaacat gaggggtctg     3360

gggaggtcag aggccccgtt tgttcccaga gcctgggcca tcactgccag tggggttctc     3420

acagtgctag cctctatatt tactatgcca actggtgcac ccctagttct ctttctccat     3480

cctattccca ttttaaaaaa cccgtcccaa actctcgtgt ttcaatggaa agactgattt     3540

atgtctcaaa agacaagagt ctcaaaggct gtgggtaagc tgaaggcttg cctccctgac     3600

agatgcttag actacaggct tcttgggaca ggtggcccct tcctaagctc acaggagtgg     3660

ccaccactct tgaccttcac tctgtctata gtcccgcctc atcctggatc ttgtactgag     3720

cggcagctaa aagtgttcta cccagtgccc tgtcactcta gactggaagg tatggggcct     3780

gatgcaaggc tgaccacacc aacaaacacc gtgtgctcct ctccaagctg actcgtcctc     3840

attaactgtc aacattaaac taacagcatt aacacagcca g                         3881


<210>  43
<211>  979
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  protein sequence of the engineered mouse CSF1R after humanization

<400>  43

Met Glu Leu Gly Pro Pro Leu Val Leu Leu Leu Ala Thr Val Trp His 
1               5                   10                  15      


Gly Gln Gly Ile Pro Val Ile Glu Pro Ser Val Pro Glu Leu Val Val 
            20                  25                  30          


Lys Pro Gly Ala Thr Val Thr Leu Arg Cys Val Gly Asn Gly Ser Val 
        35                  40                  45              


Glu Trp Asp Gly Pro Pro Ser Pro His Trp Thr Leu Tyr Ser Asp Gly 
    50                  55                  60                  


Ser Ser Ser Ile Leu Ser Thr Asn Asn Ala Thr Phe Gln Asn Thr Gly 
65                  70                  75                  80  


Thr Tyr Arg Cys Thr Glu Pro Gly Asp Pro Leu Gly Gly Ser Ala Ala 
                85                  90                  95      


Ile His Leu Tyr Val Lys Asp Pro Ala Arg Pro Trp Asn Val Leu Ala 
            100                 105                 110         


Gln Glu Val Val Val Phe Glu Asp Gln Asp Ala Leu Leu Pro Cys Leu 
        115                 120                 125             


Leu Thr Asp Pro Val Leu Glu Ala Gly Val Ser Leu Val Arg Val Arg 
    130                 135                 140                 


Gly Arg Pro Leu Met Arg His Thr Asn Tyr Ser Phe Ser Pro Trp His 
145                 150                 155                 160 


Gly Phe Thr Ile His Arg Ala Lys Phe Ile Gln Ser Gln Asp Tyr Gln 
                165                 170                 175     


Cys Ser Ala Leu Met Gly Gly Arg Lys Val Met Ser Ile Ser Ile Arg 
            180                 185                 190         


Leu Lys Val Gln Lys Val Ile Pro Gly Pro Pro Ala Leu Thr Leu Val 
        195                 200                 205             


Pro Ala Glu Leu Val Arg Ile Arg Gly Glu Ala Ala Gln Ile Val Cys 
    210                 215                 220                 


Ser Ala Ser Ser Val Asp Val Asn Phe Asp Val Phe Leu Gln His Asn 
225                 230                 235                 240 


Asn Thr Lys Leu Ala Ile Pro Gln Gln Ser Asp Phe His Asn Asn Arg 
                245                 250                 255     


Tyr Gln Lys Val Leu Thr Leu Asn Leu Asp Gln Val Asp Phe Gln His 
            260                 265                 270         


Ala Gly Asn Tyr Ser Cys Val Ala Ser Asn Val Gln Gly Lys His Ser 
        275                 280                 285             


Thr Ser Met Phe Phe Arg Val Val Glu Ser Ala Tyr Leu Asn Leu Ser 
    290                 295                 300                 


Ser Glu Gln Asn Leu Ile Gln Glu Val Thr Val Gly Glu Gly Leu Asn 
305                 310                 315                 320 


Leu Lys Val Met Val Glu Ala Tyr Pro Gly Leu Gln Gly Phe Asn Trp 
                325                 330                 335     


Thr Tyr Leu Gly Pro Phe Ser Asp His Gln Pro Glu Pro Lys Leu Ala 
            340                 345                 350         


Asn Ala Thr Thr Lys Asp Thr Tyr Arg His Thr Phe Thr Leu Ser Leu 
        355                 360                 365             


Pro Arg Leu Lys Pro Ser Glu Ala Gly Arg Tyr Ser Phe Leu Ala Arg 
    370                 375                 380                 


Asn Pro Gly Gly Trp Arg Ala Leu Thr Phe Glu Leu Thr Leu Arg Tyr 
385                 390                 395                 400 


Pro Pro Glu Val Ser Val Ile Trp Thr Phe Ile Asn Gly Ser Gly Thr 
                405                 410                 415     


Leu Leu Cys Ala Ala Ser Gly Tyr Pro Gln Pro Asn Val Thr Trp Leu 
            420                 425                 430         


Gln Cys Ser Gly His Thr Asp Arg Cys Asp Glu Ala Gln Val Leu Gln 
        435                 440                 445             


Val Trp Asp Asp Pro Tyr Pro Glu Val Leu Ser Gln Glu Pro Phe His 
    450                 455                 460                 


Lys Val Thr Val Gln Ser Leu Leu Thr Val Glu Thr Leu Glu His Asn 
465                 470                 475                 480 


Gln Thr Tyr Glu Cys Arg Ala His Asn Ser Val Gly Ser Gly Ser Trp 
                485                 490                 495     


Ala Phe Ile Pro Ile Ser Ala Gly Ala His Thr His Pro Pro Asp Glu 
            500                 505                 510         


Phe Leu Phe Thr Pro Val Val Val Ala Cys Met Ser Val Met Ser Leu 
        515                 520                 525             


Leu Val Leu Leu Leu Leu Leu Leu Leu Tyr Lys Tyr Lys Gln Lys Pro 
    530                 535                 540                 


Lys Tyr Gln Val Arg Trp Lys Ile Ile Glu Arg Tyr Glu Gly Asn Ser 
545                 550                 555                 560 


Tyr Thr Phe Ile Asp Pro Thr Gln Leu Pro Tyr Asn Glu Lys Trp Glu 
                565                 570                 575     


Phe Pro Arg Asn Asn Leu Gln Phe Gly Lys Thr Leu Gly Ala Gly Ala 
            580                 585                 590         


Phe Gly Lys Val Val Glu Ala Thr Ala Phe Gly Leu Gly Lys Glu Asp 
        595                 600                 605             


Ala Val Leu Lys Val Ala Val Lys Met Leu Lys Ser Thr Ala His Ala 
    610                 615                 620                 


Asp Glu Lys Glu Ala Leu Met Ser Glu Leu Lys Ile Met Ser His Leu 
625                 630                 635                 640 


Gly Gln His Glu Asn Ile Val Asn Leu Leu Gly Ala Cys Thr His Gly 
                645                 650                 655     


Gly Pro Val Leu Val Ile Thr Glu Tyr Cys Cys Tyr Gly Asp Leu Leu 
            660                 665                 670         


Asn Phe Leu Arg Arg Lys Ala Glu Ala Met Leu Gly Pro Ser Leu Ser 
        675                 680                 685             


Pro Gly Gln Asp Ser Glu Gly Asp Ser Ser Tyr Lys Asn Ile His Leu 
    690                 695                 700                 


Glu Lys Lys Tyr Val Arg Arg Asp Ser Gly Phe Ser Ser Gln Gly Val 
705                 710                 715                 720 


Asp Thr Tyr Val Glu Met Arg Pro Val Ser Thr Ser Ser Ser Asp Ser 
                725                 730                 735     


Phe Phe Lys Gln Asp Leu Asp Lys Glu Ala Ser Arg Pro Leu Glu Leu 
            740                 745                 750         


Trp Asp Leu Leu His Phe Ser Ser Gln Val Ala Gln Gly Met Ala Phe 
        755                 760                 765             


Leu Ala Ser Lys Asn Cys Ile His Arg Asp Val Ala Ala Arg Asn Val 
    770                 775                 780                 


Leu Leu Thr Ser Gly His Val Ala Lys Ile Gly Asp Phe Gly Leu Ala 
785                 790                 795                 800 


Arg Asp Ile Met Asn Asp Ser Asn Tyr Val Val Lys Gly Asn Ala Arg 
                805                 810                 815     


Leu Pro Val Lys Trp Met Ala Pro Glu Ser Ile Phe Asp Cys Val Tyr 
            820                 825                 830         


Thr Val Gln Ser Asp Val Trp Ser Tyr Gly Ile Leu Leu Trp Glu Ile 
        835                 840                 845             


Phe Ser Leu Gly Leu Asn Pro Tyr Pro Gly Ile Leu Val Asn Asn Lys 
    850                 855                 860                 


Phe Tyr Lys Leu Val Lys Asp Gly Tyr Gln Met Ala Gln Pro Val Phe 
865                 870                 875                 880 


Ala Pro Lys Asn Ile Tyr Ser Ile Met Gln Ser Cys Trp Asp Leu Glu 
                885                 890                 895     


Pro Thr Arg Arg Pro Thr Phe Gln Gln Ile Cys Phe Leu Leu Gln Glu 
            900                 905                 910         


Gln Ala Arg Leu Glu Arg Arg Asp Gln Asp Tyr Ala Asn Leu Pro Ser 
        915                 920                 925             


Ser Gly Gly Ser Ser Gly Ser Asp Ser Gly Gly Gly Ser Ser Gly Gly 
    930                 935                 940                 


Ser Ser Ser Glu Pro Glu Glu Glu Ser Ser Ser Glu His Leu Ala Cys 
945                 950                 955                 960 


Cys Glu Pro Gly Asp Ile Ala Gln Pro Leu Leu Gln Pro Asn Asn Tyr 
                965                 970                 975     


Gln Phe Cys 
            


<210>  44
<211>  453
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  full-length heavy chain

<400>  44

Glu Val Thr Leu Lys Glu Ser Gly Pro Ala Leu Val Lys Pro Thr Gln 
1               5                   10                  15      


Thr Leu Thr Leu Thr Cys Thr Phe Ser Gly Phe Ser Leu Thr Thr Tyr 
            20                  25                  30          


Gly Met Gly Val Gly Trp Ile Arg Gln Pro Pro Gly Lys Ala Leu Glu 
        35                  40                  45              


Trp Leu Ala Asn Ile Trp Trp Asp Asp Asp Lys Tyr Tyr Asn Pro Ser 
    50                  55                  60                  


Leu Lys Asn Arg Leu Thr Ile Ser Lys Asp Thr Ser Lys Asn Gln Val 
65                  70                  75                  80  


Val Leu Thr Met Thr Asn Met Asp Pro Val Asp Thr Ala Thr Tyr Tyr 
                85                  90                  95      


Cys Ala Arg Ile Gly Pro Ile Lys Tyr Pro Thr Ala Pro Tyr Arg Tyr 
            100                 105                 110         


Phe Asp Phe Trp Gly Gln Gly Thr Met Val Thr Val Ser Ser Ala Ser 
        115                 120                 125             


Thr Lys Gly Pro Ser Val Phe Pro Leu Ala Pro Cys Ser Arg Ser Thr 
    130                 135                 140                 


Ser Glu Ser Thr Ala Ala Leu Gly Cys Leu Val Lys Asp Tyr Phe Pro 
145                 150                 155                 160 


Glu Pro Val Thr Val Ser Trp Asn Ser Gly Ala Leu Thr Ser Gly Val 
                165                 170                 175     


His Thr Phe Pro Ala Val Leu Gln Ser Ser Gly Leu Tyr Ser Leu Ser 
            180                 185                 190         


Ser Val Val Thr Val Pro Ser Ser Ser Leu Gly Thr Lys Thr Tyr Thr 
        195                 200                 205             


Cys Asn Val Asp His Lys Pro Ser Asn Thr Lys Val Asp Lys Arg Val 
    210                 215                 220                 


Glu Ser Lys Tyr Gly Pro Pro Cys Pro Pro Cys Pro Ala Pro Glu Phe 
225                 230                 235                 240 


Leu Gly Gly Pro Ser Val Phe Leu Phe Pro Pro Lys Pro Lys Asp Thr 
                245                 250                 255     


Leu Met Ile Ser Arg Thr Pro Glu Val Thr Cys Val Val Val Asp Val 
            260                 265                 270         


Ser Gln Glu Asp Pro Glu Val Gln Phe Asn Trp Tyr Val Asp Gly Val 
        275                 280                 285             


Glu Val His Asn Ala Lys Thr Lys Pro Arg Glu Glu Gln Phe Asn Ser 
    290                 295                 300                 


Thr Tyr Arg Val Val Ser Val Leu Thr Val Leu His Gln Asp Trp Leu 
305                 310                 315                 320 


Asn Gly Lys Glu Tyr Lys Cys Lys Val Ser Asn Lys Gly Leu Pro Ser 
                325                 330                 335     


Ser Ile Glu Lys Thr Ile Ser Lys Ala Lys Gly Gln Pro Arg Glu Pro 
            340                 345                 350         


Gln Val Tyr Thr Leu Pro Pro Ser Gln Glu Glu Met Thr Lys Asn Gln 
        355                 360                 365             


Val Ser Leu Thr Cys Leu Val Lys Gly Phe Tyr Pro Ser Asp Ile Ala 
    370                 375                 380                 


Val Glu Trp Glu Ser Asn Gly Gln Pro Glu Asn Asn Tyr Lys Thr Thr 
385                 390                 395                 400 


Pro Pro Val Leu Asp Ser Asp Gly Ser Phe Phe Leu Tyr Ser Arg Leu 
                405                 410                 415     


Thr Val Asp Lys Ser Arg Trp Gln Glu Gly Asn Val Phe Ser Cys Ser 
            420                 425                 430         


Val Met His Glu Ala Leu His Asn His Tyr Thr Gln Lys Ser Leu Ser 
        435                 440                 445             


Leu Ser Leu Gly Lys 
    450             


<210>  45
<211>  169
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  full-length light chain

<400>  45

Leu Leu Ile Tyr Tyr Ala Ser Ser Leu Gln Asp Gly Val Pro Ser Arg 
1               5                   10                  15      


Phe Ser Gly Ser Gly Ser Gly Thr Asp Tyr Thr Leu Thr Ile Ser Ser 
            20                  25                  30          


Leu Gln Pro Glu Asp Phe Ala Thr Tyr Tyr Cys Leu Gln Asp Ser Glu 
        35                  40                  45              


Tyr Pro Trp Thr Phe Gly Gly Gly Thr Lys Val Glu Ile Lys Arg Thr 
    50                  55                  60                  


Val Ala Ala Pro Ser Val Phe Ile Phe Pro Pro Ser Asp Glu Gln Leu 
65                  70                  75                  80  


Lys Ser Gly Thr Ala Ser Val Val Cys Leu Leu Asn Asn Phe Tyr Pro 
                85                  90                  95      


Arg Glu Ala Lys Val Gln Trp Lys Val Asp Asn Ala Leu Gln Ser Gly 
            100                 105                 110         


Asn Ser Gln Glu Ser Val Thr Glu Gln Asp Ser Lys Asp Ser Thr Tyr 
        115                 120                 125             


Ser Leu Ser Ser Thr Leu Thr Leu Ser Lys Ala Asp Tyr Glu Lys His 
    130                 135                 140                 


Lys Val Tyr Ala Cys Glu Val Thr His Gln Gly Leu Ser Ser Pro Val 
145                 150                 155                 160 


Thr Lys Ser Phe Asn Arg Gly Glu Cys 
                165                 


<210>  46
<211>  449
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  full-length heavy chain

<400>  46

Gln Val Gln Leu Val Gln Ser Gly Ala Glu Val Lys Lys Pro Gly Ser 
1               5                   10                  15      


Ser Val Lys Val Ser Cys Lys Ala Ser Gly Tyr Thr Phe Thr Asp Asn 
            20                  25                  30          


Tyr Met Ile Trp Val Arg Gln Ala Pro Gly Gln Gly Leu Glu Trp Met 
        35                  40                  45              


Gly Asp Ile Asn Pro Tyr Asn Gly Gly Thr Thr Phe Asn Gln Lys Phe 
    50                  55                  60                  


Lys Gly Arg Val Thr Ile Thr Ala Asp Lys Ser Thr Ser Thr Ala Tyr 
65                  70                  75                  80  


Met Glu Leu Ser Ser Leu Arg Ser Glu Asp Thr Ala Val Tyr Tyr Cys 
                85                  90                  95      


Ala Arg Glu Ser Pro Tyr Phe Ser Asn Leu Tyr Val Met Asp Tyr Trp 
            100                 105                 110         


Gly Gln Gly Thr Leu Val Thr Val Ser Ser Ala Ser Thr Lys Gly Pro 
        115                 120                 125             


Ser Val Phe Pro Leu Ala Pro Cys Ser Arg Ser Thr Ser Glu Ser Thr 
    130                 135                 140                 


Ala Ala Leu Gly Cys Leu Val Lys Asp Tyr Phe Pro Glu Pro Val Thr 
145                 150                 155                 160 


Val Ser Trp Asn Ser Gly Ala Leu Thr Ser Gly Val His Thr Phe Pro 
                165                 170                 175     


Ala Val Leu Gln Ser Ser Gly Leu Tyr Ser Leu Ser Ser Val Val Thr 
            180                 185                 190         


Val Pro Ser Ser Ser Leu Gly Thr Lys Thr Tyr Thr Cys Asn Val Asp 
        195                 200                 205             


His Lys Pro Ser Asn Thr Lys Val Asp Lys Arg Val Glu Ser Lys Tyr 
    210                 215                 220                 


Gly Pro Pro Cys Pro Pro Cys Pro Ala Pro Glu Phe Leu Gly Gly Pro 
225                 230                 235                 240 


Ser Val Phe Leu Phe Pro Pro Lys Pro Lys Asp Thr Leu Met Ile Ser 
                245                 250                 255     


Arg Thr Pro Glu Val Thr Cys Val Val Val Asp Val Ser Gln Glu Asp 
            260                 265                 270         


Pro Glu Val Gln Phe Asn Trp Tyr Val Asp Gly Val Glu Val His Asn 
        275                 280                 285             


Ala Lys Thr Lys Pro Arg Glu Glu Gln Phe Asn Ser Thr Tyr Arg Val 
    290                 295                 300                 


Val Ser Val Leu Thr Val Leu His Gln Asp Trp Leu Asn Gly Lys Glu 
305                 310                 315                 320 


Tyr Lys Cys Lys Val Ser Asn Lys Gly Leu Pro Ser Ser Ile Glu Lys 
                325                 330                 335     


Thr Ile Ser Lys Ala Lys Gly Gln Pro Arg Glu Pro Gln Val Tyr Thr 
            340                 345                 350         


Leu Pro Pro Ser Gln Glu Glu Met Thr Lys Asn Gln Val Ser Leu Thr 
        355                 360                 365             


Cys Leu Val Lys Gly Phe Tyr Pro Ser Asp Ile Ala Val Glu Trp Glu 
    370                 375                 380                 


Ser Asn Gly Gln Pro Glu Asn Asn Tyr Lys Thr Thr Pro Pro Val Leu 
385                 390                 395                 400 


Asp Ser Asp Gly Ser Phe Phe Leu Tyr Ser Arg Leu Thr Val Asp Lys 
                405                 410                 415     


Ser Arg Trp Gln Glu Gly Asn Val Phe Ser Cys Ser Val Met His Glu 
            420                 425                 430         


Ala Leu His Asn His Tyr Thr Gln Lys Ser Leu Ser Leu Ser Leu Gly 
        435                 440                 445             


Lys 
    


<210>  47
<211>  218
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  full-length light chain

<400>  47

Glu Ile Val Leu Thr Gln Ser Pro Ala Thr Leu Ser Leu Ser Pro Gly 
1               5                   10                  15      


Glu Arg Ala Thr Leu Ser Cys Lys Ala Ser Gln Ser Val Asp Tyr Asp 
            20                  25                  30          


Gly Asp Asn Tyr Met Asn Trp Tyr Gln Gln Lys Pro Gly Gln Ala Pro 
        35                  40                  45              


Arg Leu Leu Ile Tyr Ala Ala Ser Asn Leu Glu Ser Gly Ile Pro Ala 
    50                  55                  60                  


Arg Phe Ser Gly Ser Gly Ser Gly Thr Asp Phe Thr Leu Thr Ile Ser 
65                  70                  75                  80  


Ser Leu Glu Pro Glu Asp Phe Ala Val Tyr Tyr Cys His Leu Ser Asn 
                85                  90                  95      


Glu Asp Leu Ser Thr Glu Gly Gly Gly Thr Lys Val Glu Ile Lys Arg 
            100                 105                 110         


Thr Val Ala Ala Pro Ser Val Phe Ile Phe Pro Pro Ser Asp Glu Gln 
        115                 120                 125             


Leu Lys Ser Gly Thr Ala Ser Val Val Cys Leu Leu Asn Asn Phe Tyr 
    130                 135                 140                 


Pro Arg Glu Ala Lys Val Gln Trp Lys Val Asp Asn Ala Leu Gln Ser 
145                 150                 155                 160 


Gly Asn Ser Gln Glu Ser Val Thr Glu Gln Asp Ser Lys Asp Ser Thr 
                165                 170                 175     


Tyr Ser Leu Ser Ser Thr Leu Thr Leu Ser Lys Ala Asp Tyr Glu Lys 
            180                 185                 190         


His Lys Val Tyr Ala Cys Glu Val Thr His Gln Gly Leu Ser Ser Pro 
        195                 200                 205             


Val Thr Lys Ser Phe Asn Arg Gly Glu Cys 
    210                 215             


<210>  48
<211>  446
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  full-length heavy chain

<400>  48

Gln Val Gln Leu Val Gln Ser Gly Ala Glu Val Lys Lys Pro Gly Ala 
1               5                   10                  15      


Ser Val Lys Val Ser Cys Lys Ala Ser Gly Tyr Thr Phe Thr Ser Tyr 
            20                  25                  30          


Asp Ile Ser Trp Val Arg Gln Ala Pro Gly Gln Gly Leu Glu Trp Met 
        35                  40                  45              


Gly Val Ile Trp Thr Asp Gly Gly Thr Asn Tyr Ala Gln Lys Leu Gln 
    50                  55                  60                  


Gly Arg Val Thr Met Thr Thr Asp Thr Ser Thr Ser Thr Ala Tyr Met 
65                  70                  75                  80  


Glu Leu Arg Ser Leu Arg Ser Asp Asp Thr Ala Val Tyr Tyr Cys Ala 
                85                  90                  95      


Arg Asp Gln Arg Leu Tyr Phe Asp Val Trp Gly Gln Gly Thr Thr Val 
            100                 105                 110         


Thr Val Ser Ser Ala Ser Thr Lys Gly Pro Ser Val Phe Pro Leu Ala 
        115                 120                 125             


Pro Ser Ser Lys Ser Thr Ser Gly Gly Thr Ala Ala Leu Gly Cys Leu 
    130                 135                 140                 


Val Lys Asp Tyr Phe Pro Glu Pro Val Thr Val Ser Trp Asn Ser Gly 
145                 150                 155                 160 


Ala Leu Thr Ser Gly Val His Thr Phe Pro Ala Val Leu Gln Ser Ser 
                165                 170                 175     


Gly Leu Tyr Ser Leu Ser Ser Val Val Thr Val Pro Ser Ser Ser Leu 
            180                 185                 190         


Gly Thr Gln Thr Tyr Ile Cys Asn Val Asn His Lys Pro Ser Asn Thr 
        195                 200                 205             


Lys Val Asp Lys Lys Val Glu Pro Lys Ser Cys Asp Lys Thr His Thr 
    210                 215                 220                 


Cys Pro Pro Cys Pro Ala Pro Glu Leu Leu Gly Gly Pro Ser Val Phe 
225                 230                 235                 240 


Leu Phe Pro Pro Lys Pro Lys Asp Thr Leu Met Ile Ser Arg Thr Pro 
                245                 250                 255     


Glu Val Thr Cys Val Val Val Asp Val Ser His Glu Asp Pro Glu Val 
            260                 265                 270         


Lys Phe Asn Trp Tyr Val Asp Gly Val Glu Val His Asn Ala Lys Thr 
        275                 280                 285             


Lys Pro Arg Glu Glu Gln Tyr Asn Ser Thr Tyr Arg Val Val Ser Val 
    290                 295                 300                 


Leu Thr Val Leu His Gln Asp Trp Leu Asn Gly Lys Glu Tyr Lys Cys 
305                 310                 315                 320 


Lys Val Ser Asn Lys Ala Leu Pro Ala Pro Ile Glu Lys Thr Ile Ser 
                325                 330                 335     


Lys Ala Lys Gly Gln Pro Arg Glu Pro Gln Val Tyr Thr Leu Pro Pro 
            340                 345                 350         


Ser Arg Asp Glu Leu Thr Lys Asn Gln Val Ser Leu Thr Cys Leu Val 
        355                 360                 365             


Lys Gly Phe Tyr Pro Ser Asp Ile Ala Val Glu Trp Glu Ser Asn Gly 
    370                 375                 380                 


Gln Pro Glu Asn Asn Tyr Lys Thr Thr Pro Pro Val Leu Asp Ser Asp 
385                 390                 395                 400 


Gly Ser Phe Phe Leu Tyr Ser Lys Leu Thr Val Asp Lys Ser Arg Trp 
                405                 410                 415     


Gln Gln Gly Asn Val Phe Ser Cys Ser Val Met His Glu Ala Leu His 
            420                 425                 430         


Asn His Tyr Thr Gln Lys Ser Leu Ser Leu Ser Pro Gly Lys 
        435                 440                 445     


<210>  49
<211>  213
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  full-length light chain

<400>  49

Asp Ile Gln Met Thr Gln Ser Pro Ser Ser Leu Ser Ala Ser Val Gly 
1               5                   10                  15      


Asp Arg Val Thr Ile Thr Cys Arg Ala Ser Glu Asp Val Asn Thr Tyr 
            20                  25                  30          


Val Ser Trp Tyr Gln Gln Lys Pro Gly Lys Ala Pro Lys Leu Leu Ile 
        35                  40                  45              


Tyr Ala Ala Ser Asn Arg Tyr Thr Gly Val Pro Ser Arg Phe Ser Gly 
    50                  55                  60                  


Ser Gly Ser Gly Thr Asp Phe Thr Leu Thr Ile Ser Ser Leu Gln Pro 
65                  70                  75                  80  


Glu Asp Phe Ala Thr Tyr Tyr Cys Gln Gln Ser Phe Ser Tyr Pro Thr 
                85                  90                  95      


Phe Gly Gln Gly Thr Lys Leu Glu Ile Lys Arg Thr Val Ala Ala Pro 
            100                 105                 110         


Ser Val Phe Ile Phe Pro Pro Ser Asp Glu Gln Leu Lys Ser Gly Thr 
        115                 120                 125             


Ala Ser Val Val Cys Leu Leu Asn Asn Phe Tyr Pro Arg Glu Ala Lys 
    130                 135                 140                 


Val Gln Trp Lys Val Asp Asn Ala Leu Gln Ser Gly Asn Ser Gln Glu 
145                 150                 155                 160 


Ser Val Thr Glu Gln Asp Ser Lys Asp Ser Thr Tyr Ser Leu Ser Ser 
                165                 170                 175     


Thr Leu Thr Leu Ser Lys Ala Asp Tyr Glu Lys His Lys Val Tyr Ala 
            180                 185                 190         


Cys Glu Val Thr His Gln Gly Leu Ser Ser Pro Val Thr Lys Ser Phe 
        195                 200                 205             


Asn Arg Gly Glu Cys 
    210             


<210>  50
<211>  120
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  heavy chain variable region

<400>  50

Gln Asp Gln Leu Val Glu Ser Gly Gly Gly Val Val Gln Pro Gly Arg 
1               5                   10                  15      


Ser Leu Arg Leu Ser Cys Ala Ala Ser Gly Phe Thr Phe Ser Ser Tyr 
            20                  25                  30          


Gly Met His Trp Val Arg Gln Ala Pro Gly Glu Gly Leu Glu Trp Val 
        35                  40                  45              


Ala Val Ile Trp Tyr Asp Gly Ser Asn Lys Tyr Tyr Ala Asp Ser Val 
    50                  55                  60                  


Lys Gly Arg Phe Thr Ile Ser Arg Asp Asn Ser Lys Asn Thr Leu Tyr 
65                  70                  75                  80  


Leu Gln Met Asn Ser Leu Arg Ala Glu Asp Thr Ala Val Tyr Tyr Cys 
                85                  90                  95      


Ala Arg Gly Asp Tyr Glu Val Asp Tyr Gly Met Asp Val Trp Gly Gln 
            100                 105                 110         


Gly Thr Thr Val Thr Val Ala Ser 
        115                 120 


<210>  51
<211>  107
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  light chain variable region

<400>  51

Ala Ile Gln Leu Thr Gln Ser Pro Ser Ser Leu Ser Ala Ser Val Gly 
1               5                   10                  15      


Asp Arg Val Thr Ile Thr Cys Arg Ala Ser Gln Gly Ile Ser Asn Ala 
            20                  25                  30          


Leu Ala Trp Tyr Gln Gln Lys Pro Gly Lys Ala Pro Lys Leu Leu Ile 
        35                  40                  45              


Tyr Asp Ala Ser Ser Leu Glu Ser Gly Val Pro Ser Arg Phe Ser Gly 
    50                  55                  60                  


Ser Gly Ser Gly Thr Asp Phe Thr Leu Thr Ile Ser Ser Leu Gln Pro 
65                  70                  75                  80  


Glu Asp Phe Ala Thr Tyr Tyr Cys Gln Gln Phe Asn Ser Tyr Pro Trp 
                85                  90                  95      


Thr Phe Gly Gln Gly Thr Lys Val Glu Ile Lys 
            100                 105         


<210>  52
<211>  566
<212>  PRT
<213>  Rattus norvegicus

<400>  52

Met Thr Ala Arg Gly Ala Ala Gly Arg Cys Pro Ser Ser Thr Trp Met 
1               5                   10                  15      


Gly Ser Arg Leu Leu Leu Val Cys Leu Leu Val Ser Arg Ser Val Ala 
            20                  25                  30          


Glu Val Ser Glu His Cys Ser His Met Ile Gly Asn Gly His Leu Gln 
        35                  40                  45              


Ile Leu Gln Gln Leu Ile Asp Ser Gln Met Glu Thr Ala Cys Leu Ile 
    50                  55                  60                  


Glu Tyr Lys Phe Val Asp Gln Glu Gln Leu Asp Asp Pro Val Cys Tyr 
65                  70                  75                  80  


Leu Lys Lys Ala Phe Val Leu Val Gln Val Ile Ile Glu Glu Thr Met 
                85                  90                  95      


Arg Phe Lys Asp Asn Thr Pro Asn Ala Asn Ala Thr Glu Arg Leu Gln 
            100                 105                 110         


Glu Leu Ser Met Lys Leu Asn Ser Cys Phe Ile Lys Asp Tyr Lys Glu 
        115                 120                 125             


Gln Asn Glu Ala Cys Val Gln Thr Tyr Lys Glu Ser Pro Leu Arg Leu 
    130                 135                 140                 


Leu Glu Lys Ile Lys Asn Phe Phe Asn Glu Thr Lys Asn Phe Leu Glu 
145                 150                 155                 160 


Lys Asp Trp Asn Ile Phe Ser Lys Asn Cys Asn Asp Ser Leu Ala Lys 
                165                 170                 175     


Cys Ser Ser Arg Asp Val Val Thr Lys Pro Asp Cys Asn Cys Leu Tyr 
            180                 185                 190         


Pro Lys Ala Thr Pro Ser Ser Asp Leu Ala Ser Ala Ser Pro His Gln 
        195                 200                 205             


Pro Pro Ala Pro Ser Met Ala Pro Leu Ala Asp Leu Ala Trp Asp Asp 
    210                 215                 220                 


Ser Gln Arg Thr Glu Gly Ser Ser Leu Leu Pro Ser Asp Leu Pro Leu 
225                 230                 235                 240 


Arg Ile Glu Asp Pro Gly Ser Ala Lys Gln Arg Pro Pro Arg Ser Thr 
                245                 250                 255     


Cys Gln Thr Leu Glu Ser Thr Glu Gln Pro Asn His Glu Asp Pro Gln 
            260                 265                 270         


Pro His Pro Ser Ala Gly Ala Pro Ile Pro Gly Val Glu Asp Ile Ile 
        275                 280                 285             


Glu Ser Ser Met Gly Thr Asn Trp Val Leu Glu Glu Ala Ser Gly Glu 
    290                 295                 300                 


Ala Ser Glu Gly Phe Leu Thr Gln Glu Arg Lys Phe Ser Pro Ser Asn 
305                 310                 315                 320 


Pro Val Gly Gly Ser Ile Gln Ala Glu Thr Asp Arg Pro Trp Ala Arg 
                325                 330                 335     


Ser Ala Ser Ser Pro Phe Pro Lys Leu Thr Glu Asp Gln Gln Pro Thr 
            340                 345                 350         


Asn Ile Thr Asp Thr Pro Leu Thr Glu Val Asn Pro Met Arg Pro Thr 
        355                 360                 365             


Gly Gln Thr Leu Asn Asn Thr Pro Glu Lys Thr Asp Gly Ser Ser Thr 
    370                 375                 380                 


Leu Arg Glu Asp Gln Gln Glu Pro Arg Ser Pro His Phe Ala Thr Leu 
385                 390                 395                 400 


Asn Pro Gln Arg Val Gly Asn Ser Ala Thr Pro Tyr Ala Lys Leu Leu 
                405                 410                 415     


Pro Pro Lys Ser His Ser Trp Gly Ile Val Leu Pro Leu Gly Glu Leu 
            420                 425                 430         


Glu Gly Lys Lys Ser Thr Arg Asp Arg Arg Ser Pro Ala Glu Leu Lys 
        435                 440                 445             


Gly Gly Pro Ala Ser Glu Gly Ala Ala Arg Pro Val Ala Gln Ser Thr 
    450                 455                 460                 


Arg Asp Arg Arg Ser Pro Ala Glu Leu Lys Gly Gly Pro Ala Ser Glu 
465                 470                 475                 480 


Gly Ala Ala Arg Pro Val Ala Arg Phe Asn Ser Ile Pro Leu Thr Asp 
                485                 490                 495     


Thr Gly Ser Ser Ile Gln Asp Pro Gln Thr Ser Ala Phe Val Phe Trp 
            500                 505                 510         


Val Leu Gly Ile Ile Leu Val Leu Leu Ala Val Gly Gly Leu Leu Phe 
        515                 520                 525             


Tyr Ser Trp Lys Arg Arg Ser His Arg Asp Pro Arg Thr Leu Asp Ser 
    530                 535                 540                 


Ser Val Gly Arg Pro Glu Gly Ser Ser Leu Ala Gln Asp Glu Asp Arg 
545                 550                 555                 560 


Gln Val Glu Leu Pro Val 
                565     


<210>  53
<211>  1022
<212>  PRT
<213>  Rattus norvegicus

<400>  53

Met Glu Leu Gly Ala Pro Leu Val Leu Leu Leu Ala Thr Ala Trp His 
1               5                   10                  15      


Gly Val Gln Ile Leu Ser Gly Glu Lys Ser Arg Thr Thr Ile His Ile 
            20                  25                  30          


Tyr Leu Leu Ala Gly Arg Arg Ala Val Thr Thr Glu Ile Val Leu Met 
        35                  40                  45              


Gly Gln Arg Ser Thr Asp Val Gln Arg Val Asn Asp Cys Gln Gly Ala 
    50                  55                  60                  


Pro Val Ile Glu Pro Ser Gly Pro Glu Leu Val Val Glu Pro Gly Ala 
65                  70                  75                  80  


Thr Val Thr Leu Arg Cys Val Ser Asn Gly Ser Val Glu Trp Asp Gly 
                85                  90                  95      


Pro Ile Ser Pro Tyr Trp Thr Leu Asp Ser Glu Ser Pro Gly Ser Ile 
            100                 105                 110         


Leu Ile Thr Lys Asn Ala Thr Phe Lys Asn Thr Gly Thr Tyr Arg Cys 
        115                 120                 125             


Thr Glu Leu Glu Asp Pro Met Arg Gly Ser Thr Ala Ile His Leu Tyr 
    130                 135                 140                 


Val Lys Asp Pro Val Arg Pro Trp Asn Leu Leu Ala Gln Glu Val Thr 
145                 150                 155                 160 


Val Phe Glu Gly Gln Glu Ala Val Leu Pro Cys Leu Ile Thr Asp Pro 
                165                 170                 175     


Thr Leu Lys Asp Ser Val Ser Leu Val Arg Glu Trp Gly Arg Pro Val 
            180                 185                 190         


Ser Arg Lys Thr Val Tyr Ser Phe Leu Pro Trp Arg Gly Phe Ile Ile 
        195                 200                 205             


His Lys Ala Lys Phe Leu Asp Ser His Thr Tyr Met Cys Lys Ala Val 
    210                 215                 220                 


Val Asn Ala Arg Glu Ser Thr Ser Ile Gly Ile Arg Leu Lys Val Asn 
225                 230                 235                 240 


Arg Ala His Pro Gly Pro Pro His Ile Ile Leu Glu Pro Thr Lys Leu 
                245                 250                 255     


Val Arg Ile Arg Gly Glu Ala Ala Gln Ile Val Cys Ser Ala Thr His 
            260                 265                 270         


Ser Glu Val Glu Phe Asn Val Ile Leu Lys Arg Gly Asp Thr Lys Leu 
        275                 280                 285             


Glu Ile Pro Ile Asn Ser Asp Phe Gln Asp Asn Ala Tyr Lys Lys Val 
    290                 295                 300                 


Leu Thr Leu Asn Leu Asn Ala Val Asp Phe Gln Asp Ala Gly Ile Tyr 
305                 310                 315                 320 


Ser Cys Val Ala Asn Asn Ala Ala Gly Ser Asn Thr Ala Thr Met Asn 
                325                 330                 335     


Phe Gln Val Val Glu Ser Ala Tyr Leu Asn Leu Thr Ser Glu Gln Ser 
            340                 345                 350         


Leu Leu Gln Glu Val Ser Val Gly Glu Asn Leu Asp Leu Thr Val Ile 
        355                 360                 365             


Ala Asp Ala Tyr Pro Gly Leu Gln Arg Tyr Asn Trp Thr Tyr Leu Gly 
    370                 375                 380                 


Pro Phe Phe Glu Asp Pro His Asn Leu Glu Phe Arg Thr Gln Trp Thr 
385                 390                 395                 400 


Thr Tyr Ser Tyr Ser Phe Lys Leu His Leu Asn Arg Val Lys Pro Leu 
                405                 410                 415     


Glu Ala Gly Arg Tyr Ser Leu Met Ala Gln Asn Lys Ala Gly Trp Asn 
            420                 425                 430         


Asn Leu Thr Phe Glu Leu Thr Leu Arg Tyr Pro Pro Glu Val Ser Val 
        435                 440                 445             


Thr Trp Ile Pro Val Asn Gly Ser Asp Val Leu Leu Cys Asp Val Ser 
    450                 455                 460                 


Gly Tyr Pro Gln Pro Asn Val Thr Trp Met Glu Cys Arg Gly His Thr 
465                 470                 475                 480 


Asp Arg Cys Asp Glu Ala Gln Ala Ser Gln Val Trp Asp Asp Thr Gln 
                485                 490                 495     


Pro Glu Val Leu Ser Gln Lys Pro Phe His Arg Val Ile Leu Gln Ser 
            500                 505                 510         


Gln Leu Pro Ile Gly Thr Leu Lys His Asn Met Thr Tyr Val Cys Arg 
        515                 520                 525             


Ala His Asn Asn Val Gly Asn Ser Ser Gln Phe Phe Arg Ala Ile Ser 
    530                 535                 540                 


Leu Gly Gln Ser Lys Gln Leu Pro Asp Glu Tyr Leu Phe Thr Pro Val 
545                 550                 555                 560 


Val Val Ala Cys Ile Ser Val Met Ser Leu Leu Val Leu Leu Leu Leu 
                565                 570                 575     


Leu Leu Leu Tyr Lys Tyr Lys Gln Lys Pro Lys Tyr Gln Val Arg Trp 
            580                 585                 590         


Lys Ile Ile Glu Ser Tyr Glu Gly Asn Asn Tyr Thr Phe Ile Asp Pro 
        595                 600                 605             


Thr Gln Leu Pro Tyr Asn Glu Lys Trp Glu Phe Pro Arg Asn Asn Leu 
    610                 615                 620                 


Gln Phe Gly Lys Thr Leu Gly Ala Gly Ala Phe Gly Lys Val Val Glu 
625                 630                 635                 640 


Ala Thr Ala Phe Gly Leu Gly Lys Glu Asp Ala Val Leu Lys Val Ala 
                645                 650                 655     


Val Lys Met Leu Lys Ser Thr Ala His Ala Asp Glu Lys Glu Ala Leu 
            660                 665                 670         


Met Ser Glu Leu Lys Ile Met Ser His Leu Gly Gln His Glu Asn Ile 
        675                 680                 685             


Val Asn Leu Leu Gly Ala Cys Thr His Gly Gly Pro Val Leu Val Ile 
    690                 695                 700                 


Thr Glu Tyr Cys Cys Tyr Gly Asp Leu Leu Asn Phe Leu Arg Arg Lys 
705                 710                 715                 720 


Ala Glu Ala Met Leu Gly Pro Ser Leu Ser Pro Gly Gln Asp Pro Glu 
                725                 730                 735     


Gly Asp Ser Ser Tyr Lys Asn Ile His Leu Glu Lys Lys Tyr Val Arg 
            740                 745                 750         


Arg Asp Ser Gly Phe Ser Ser Gln Gly Val Asp Thr Tyr Val Glu Met 
        755                 760                 765             


Arg Pro Val Ser Thr Ser Ser Asn Asp Ser Phe Phe Lys Gln Asp Leu 
    770                 775                 780                 


Asp Lys Glu Ala Ser Arg Pro Leu Glu Leu Trp Asp Leu Leu His Phe 
785                 790                 795                 800 


Ser Ser Gln Val Ala Gln Gly Met Ala Phe Leu Ala Ser Lys Asn Cys 
                805                 810                 815     


Ile His Arg Asp Val Ala Ala Arg Asn Val Leu Leu Thr Ser Gly His 
            820                 825                 830         


Val Ala Lys Ile Gly Asp Phe Gly Leu Ala Arg Asp Ile Met Asn Asp 
        835                 840                 845             


Ser Asn Tyr Val Val Lys Gly Asn Ala Arg Leu Pro Val Lys Trp Met 
    850                 855                 860                 


Ala Pro Glu Ser Ile Phe Asp Cys Val Tyr Thr Val Gln Ser Asp Val 
865                 870                 875                 880 


Trp Ser Tyr Gly Ile Leu Leu Trp Glu Ile Phe Ser Leu Gly Leu Asn 
                885                 890                 895     


Pro Tyr Pro Gly Ile Leu Val Asn Asn Lys Phe Tyr Lys Leu Val Lys 
            900                 905                 910         


Asp Gly Tyr Gln Met Ala Gln Pro Val Phe Ala Pro Glu Asn Ile Tyr 
        915                 920                 925             


Ser Ile Met Gln Ser Cys Trp Asp Leu Glu Pro Thr Lys Arg Pro Thr 
    930                 935                 940                 


Phe Gln Gln Ile Cys Phe Leu Leu Gln Glu Gln Ala Arg Leu Glu Arg 
945                 950                 955                 960 


Arg Glu Gln Asp Tyr Ala Asn Leu Pro Ser Ser Ser Ser Ser Ser Ser 
                965                 970                 975     


Ser Ser Ser Asp Ser Gly Gly Gly Ser Gly Gly Ser Ser Ser Glu Pro 
            980                 985                 990         


Glu Glu Glu Ser Ser Ser Glu His  Leu Ala Cys Cys Glu  Pro Gly Asp 
        995                 1000                 1005             


Ile Ala  Gln Pro Leu Leu Gln  Pro Asn Asn Tyr Gln  Phe Cys 
    1010                 1015                 1020         


