﻿                         序列表

<110>  河北森朗生物科技有限公司

<120>  靶向CD19的嵌合抗原受体、制备方法及其应用

<150>  2021104372658
<151>  2021-04-22

<160>  13

<170>  SIPOSequenceListing 1.0

<210>  1
<211>  248
<212>  PRT
<213>  人工序列(Artificial Sequence)

<400>  1
Glu Val Gln Leu Val Glu Ser Gly Gly Gly Leu Val Lys Pro Gly Gly 
1               5                   10                  15      
Ser Leu Lys Leu Ser Cys Ala Ala Ser Gly Tyr Thr Phe Thr Ser Tyr 
            20                  25                  30          
Val Met His Trp Val Arg Gln Ala Pro Gly Lys Gly Leu Glu Trp Ile 
        35                  40                  45              
Gly Tyr Ile Asn Pro Tyr Asn Asp Gly Thr Lys Tyr Asn Glu Lys Phe 
    50                  55                  60                  
Gln Gly Arg Val Thr Ile Ser Ser Asp Lys Ser Ile Ser Thr Ala Tyr 
65                  70                  75                  80  
Met Glu Leu Ser Ser Leu Arg Ser Glu Asp Thr Ala Met Tyr Tyr Cys 
                85                  90                  95      
Ala Arg Gly Thr Tyr Tyr Tyr Gly Thr Arg Val Phe Asp Tyr Trp Gly 
            100                 105                 110         
Gln Gly Thr Leu Val Thr Val Ser Ser Gly Gly Gly Gly Ser Gly Gly 
        115                 120                 125             
Gly Gly Ser Gly Gly Gly Gly Ser Asp Ile Val Met Thr Gln Ser Pro 
    130                 135                 140                 
Ala Thr Leu Ser Leu Ser Pro Gly Glu Arg Ala Thr Leu Ser Cys Arg 
145                 150                 155                 160 
Ser Ser Lys Ser Leu Gln Asn Val Asn Gly Asn Thr Tyr Leu Tyr Trp 
                165                 170                 175     
Phe Gln Gln Lys Pro Gly Gln Ser Pro Gln Leu Leu Ile Tyr Arg Met 
            180                 185                 190         
Ser Asn Leu Asn Ser Gly Val Pro Asp Arg Phe Ser Gly Ser Gly Ser 
        195                 200                 205             
Gly Thr Glu Phe Thr Leu Thr Ile Ser Ser Leu Glu Pro Glu Asp Phe 
    210                 215                 220                 
Ala Val Tyr Tyr Cys Met Gln His Leu Glu Tyr Pro Ile Thr Phe Gly 
225                 230                 235                 240 
Ala Gly Thr Lys Leu Glu Ile Lys 
                245             

<210>  2
<211>  13
<212>  PRT
<213>  人工序列(Artificial Sequence)

<400>  2
Glu Ser Lys Tyr Gly Pro Pro Cys Pro Pro Cys Pro Met 
1               5                   10              

<210>  3
<211>  27
<212>  PRT
<213>  人工序列(Artificial Sequence)

<400>  3
Phe Trp Val Leu Val Val Val Gly Gly Val Leu Ala Cys Tyr Ser Leu 
1               5                   10                  15      
Leu Val Thr Val Ala Phe Ile Ile Phe Trp Val 
            20                  25          

<210>  4
<211>  42
<212>  PRT
<213>  人工序列(Artificial Sequence)

<400>  4
Lys Arg Gly Arg Lys Lys Leu Leu Tyr Ile Phe Lys Gln Pro Phe Met 
1               5                   10                  15      
Arg Pro Val Gln Thr Thr Gln Glu Glu Asp Gly Cys Ser Cys Arg Phe 
            20                  25                  30          
Pro Glu Glu Glu Glu Gly Gly Cys Glu Leu 
        35                  40          

<210>  5
<211>  112
<212>  PRT
<213>  人工序列(Artificial Sequence)

<400>  5
Arg Val Lys Phe Ser Arg Ser Ala Asp Ala Pro Ala Tyr Gln Gln Gly 
1               5                   10                  15      
Gln Asn Gln Leu Tyr Asn Glu Leu Asn Leu Gly Arg Arg Glu Glu Tyr 
            20                  25                  30          
Asp Val Leu Asp Lys Arg Arg Gly Arg Asp Pro Glu Met Gly Gly Lys 
        35                  40                  45              
Pro Arg Arg Lys Asn Pro Gln Glu Gly Leu Tyr Asn Glu Leu Gln Lys 
    50                  55                  60                  
Asp Lys Met Ala Glu Ala Tyr Ser Glu Ile Gly Met Lys Gly Glu Arg 
65                  70                  75                  80  
Arg Arg Gly Lys Gly His Asp Gly Leu Tyr Gln Gly Leu Ser Thr Ala 
                85                  90                  95      
Thr Lys Asp Thr Tyr Asp Ala Leu His Met Gln Ala Leu Pro Pro Arg 
            100                 105                 110         

<210>  6
<211>  823
<212>  PRT
<213>  人工序列(Artificial Sequence)

<400>  6
Glu Val Gln Leu Val Glu Ser Gly Gly Gly Leu Val Lys Pro Gly Gly 
1               5                   10                  15      
Ser Leu Lys Leu Ser Cys Ala Ala Ser Gly Tyr Thr Phe Thr Ser Tyr 
            20                  25                  30          
Val Met His Trp Val Arg Gln Ala Pro Gly Lys Gly Leu Glu Trp Ile 
        35                  40                  45              
Gly Tyr Ile Asn Pro Tyr Asn Asp Gly Thr Lys Tyr Asn Glu Lys Phe 
    50                  55                  60                  
Gln Gly Arg Val Thr Ile Ser Ser Asp Lys Ser Ile Ser Thr Ala Tyr 
65                  70                  75                  80  
Met Glu Leu Ser Ser Leu Arg Ser Glu Asp Thr Ala Met Tyr Tyr Cys 
                85                  90                  95      
Ala Arg Gly Thr Tyr Tyr Tyr Gly Thr Arg Val Phe Asp Tyr Trp Gly 
            100                 105                 110         
Gln Gly Thr Leu Val Thr Val Ser Ser Gly Gly Gly Gly Ser Gly Gly 
        115                 120                 125             
Gly Gly Ser Gly Gly Gly Gly Ser Asp Ile Val Met Thr Gln Ser Pro 
    130                 135                 140                 
Ala Thr Leu Ser Leu Ser Pro Gly Glu Arg Ala Thr Leu Ser Cys Arg 
145                 150                 155                 160 
Ser Ser Lys Ser Leu Gln Asn Val Asn Gly Asn Thr Tyr Leu Tyr Trp 
                165                 170                 175     
Phe Gln Gln Lys Pro Gly Gln Ser Pro Gln Leu Leu Ile Tyr Arg Met 
            180                 185                 190         
Ser Asn Leu Asn Ser Gly Val Pro Asp Arg Phe Ser Gly Ser Gly Ser 
        195                 200                 205             
Gly Thr Glu Phe Thr Leu Thr Ile Ser Ser Leu Glu Pro Glu Asp Phe 
    210                 215                 220                 
Ala Val Tyr Tyr Cys Met Gln His Leu Glu Tyr Pro Ile Thr Phe Gly 
225                 230                 235                 240 
Ala Gly Thr Lys Leu Glu Ile Lys Glu Ser Lys Tyr Gly Pro Pro Cys 
                245                 250                 255     
Pro Pro Cys Pro Met Phe Trp Val Leu Val Val Val Gly Gly Val Leu 
            260                 265                 270         
Ala Cys Tyr Ser Leu Leu Val Thr Val Ala Phe Ile Ile Phe Trp Val 
        275                 280                 285             
Lys Arg Gly Arg Lys Lys Leu Leu Tyr Ile Phe Lys Gln Pro Phe Met 
    290                 295                 300                 
Arg Pro Val Gln Thr Thr Gln Glu Glu Asp Gly Cys Ser Cys Arg Phe 
305                 310                 315                 320 
Pro Glu Glu Glu Glu Gly Gly Cys Glu Leu Arg Val Lys Phe Ser Arg 
                325                 330                 335     
Ser Ala Asp Ala Pro Ala Tyr Gln Gln Gly Gln Asn Gln Leu Tyr Asn 
            340                 345                 350         
Glu Leu Asn Leu Gly Arg Arg Glu Glu Tyr Asp Val Leu Asp Lys Arg 
        355                 360                 365             
Arg Gly Arg Asp Pro Glu Met Gly Gly Lys Pro Arg Arg Lys Asn Pro 
    370                 375                 380                 
Gln Glu Gly Leu Tyr Asn Glu Leu Gln Lys Asp Lys Met Ala Glu Ala 
385                 390                 395                 400 
Tyr Ser Glu Ile Gly Met Lys Gly Glu Arg Arg Arg Gly Lys Gly His 
                405                 410                 415     
Asp Gly Leu Tyr Gln Gly Leu Ser Thr Ala Thr Lys Asp Thr Tyr Asp 
            420                 425                 430         
Ala Leu His Met Gln Ala Leu Pro Pro Arg Leu Glu Gly Gly Gly Glu 
        435                 440                 445             
Gly Arg Gly Ser Leu Leu Thr Cys Gly Asp Val Glu Glu Asn Pro Gly 
    450                 455                 460                 
Pro Arg Met Leu Leu Leu Val Thr Ser Leu Leu Leu Cys Glu Leu Pro 
465                 470                 475                 480 
His Pro Ala Phe Leu Leu Ile Pro Arg Lys Val Cys Asn Gly Ile Gly 
                485                 490                 495     
Ile Gly Glu Phe Lys Asp Ser Leu Ser Ile Asn Ala Thr Asn Ile Lys 
            500                 505                 510         
His Phe Lys Asn Cys Thr Ser Ile Ser Gly Asp Leu His Ile Leu Pro 
        515                 520                 525             
Val Ala Phe Arg Gly Asp Ser Phe Thr His Thr Pro Pro Leu Asp Pro 
    530                 535                 540                 
Gln Glu Leu Asp Ile Leu Lys Thr Val Lys Glu Ile Thr Gly Phe Leu 
545                 550                 555                 560 
Leu Ile Gln Ala Trp Pro Glu Asn Arg Thr Asp Leu His Ala Phe Glu 
                565                 570                 575     
Asn Leu Glu Ile Ile Arg Gly Arg Thr Lys Gln His Gly Gln Phe Ser 
            580                 585                 590         
Leu Ala Val Val Ser Leu Asn Ile Thr Ser Leu Gly Leu Arg Ser Leu 
        595                 600                 605             
Lys Glu Ile Ser Asp Gly Asp Val Ile Ile Ser Gly Asn Lys Asn Leu 
    610                 615                 620                 
Cys Tyr Ala Asn Thr Ile Asn Trp Lys Lys Leu Phe Gly Thr Ser Gly 
625                 630                 635                 640 
Gln Lys Thr Lys Ile Ile Ser Asn Arg Gly Glu Asn Ser Cys Lys Ala 
                645                 650                 655     
Thr Gly Gln Val Cys His Ala Leu Cys Ser Pro Glu Gly Cys Trp Gly 
            660                 665                 670         
Pro Glu Pro Arg Asp Cys Val Ser Cys Arg Asn Val Ser Arg Gly Arg 
        675                 680                 685             
Glu Cys Val Asp Lys Cys Asn Leu Leu Glu Gly Glu Pro Arg Glu Phe 
    690                 695                 700                 
Val Glu Asn Ser Glu Cys Ile Gln Cys His Pro Glu Cys Leu Pro Gln 
705                 710                 715                 720 
Ala Met Asn Ile Thr Cys Thr Gly Arg Gly Pro Asp Asn Cys Ile Gln 
                725                 730                 735     
Cys Ala His Tyr Ile Asp Gly Pro His Cys Val Lys Thr Cys Pro Ala 
            740                 745                 750         
Gly Val Met Gly Glu Asn Asn Thr Leu Val Trp Lys Tyr Ala Asp Ala 
        755                 760                 765             
Gly His Val Cys His Leu Cys His Pro Asn Cys Thr Tyr Gly Cys Thr 
    770                 775                 780                 
Gly Pro Gly Leu Glu Gly Cys Pro Thr Asn Gly Pro Lys Ile Pro Ser 
785                 790                 795                 800 
Ile Ala Thr Gly Met Val Gly Ala Leu Leu Leu Leu Leu Val Val Ala 
                805                 810                 815     
Leu Gly Ile Gly Leu Phe Met 
            820             

<210>  7
<211>  24
<212>  PRT
<213>  人工序列(Artificial Sequence)

<400>  7
Leu Glu Gly Gly Gly Glu Gly Arg Gly Ser Leu Leu Thr Cys Gly Asp 
1               5                   10                  15      
Val Glu Glu Asn Pro Gly Pro Arg 
            20                  

<210>  8
<211>  357
<212>  PRT
<213>  人工序列(Artificial Sequence)

<400>  8
Met Leu Leu Leu Val Thr Ser Leu Leu Leu Cys Glu Leu Pro His Pro 
1               5                   10                  15      
Ala Phe Leu Leu Ile Pro Arg Lys Val Cys Asn Gly Ile Gly Ile Gly 
            20                  25                  30          
Glu Phe Lys Asp Ser Leu Ser Ile Asn Ala Thr Asn Ile Lys His Phe 
        35                  40                  45              
Lys Asn Cys Thr Ser Ile Ser Gly Asp Leu His Ile Leu Pro Val Ala 
    50                  55                  60                  
Phe Arg Gly Asp Ser Phe Thr His Thr Pro Pro Leu Asp Pro Gln Glu 
65                  70                  75                  80  
Leu Asp Ile Leu Lys Thr Val Lys Glu Ile Thr Gly Phe Leu Leu Ile 
                85                  90                  95      
Gln Ala Trp Pro Glu Asn Arg Thr Asp Leu His Ala Phe Glu Asn Leu 
            100                 105                 110         
Glu Ile Ile Arg Gly Arg Thr Lys Gln His Gly Gln Phe Ser Leu Ala 
        115                 120                 125             
Val Val Ser Leu Asn Ile Thr Ser Leu Gly Leu Arg Ser Leu Lys Glu 
    130                 135                 140                 
Ile Ser Asp Gly Asp Val Ile Ile Ser Gly Asn Lys Asn Leu Cys Tyr 
145                 150                 155                 160 
Ala Asn Thr Ile Asn Trp Lys Lys Leu Phe Gly Thr Ser Gly Gln Lys 
                165                 170                 175     
Thr Lys Ile Ile Ser Asn Arg Gly Glu Asn Ser Cys Lys Ala Thr Gly 
            180                 185                 190         
Gln Val Cys His Ala Leu Cys Ser Pro Glu Gly Cys Trp Gly Pro Glu 
        195                 200                 205             
Pro Arg Asp Cys Val Ser Cys Arg Asn Val Ser Arg Gly Arg Glu Cys 
    210                 215                 220                 
Val Asp Lys Cys Asn Leu Leu Glu Gly Glu Pro Arg Glu Phe Val Glu 
225                 230                 235                 240 
Asn Ser Glu Cys Ile Gln Cys His Pro Glu Cys Leu Pro Gln Ala Met 
                245                 250                 255     
Asn Ile Thr Cys Thr Gly Arg Gly Pro Asp Asn Cys Ile Gln Cys Ala 
            260                 265                 270         
His Tyr Ile Asp Gly Pro His Cys Val Lys Thr Cys Pro Ala Gly Val 
        275                 280                 285             
Met Gly Glu Asn Asn Thr Leu Val Trp Lys Tyr Ala Asp Ala Gly His 
    290                 295                 300                 
Val Cys His Leu Cys His Pro Asn Cys Thr Tyr Gly Cys Thr Gly Pro 
305                 310                 315                 320 
Gly Leu Glu Gly Cys Pro Thr Asn Gly Pro Lys Ile Pro Ser Ile Ala 
                325                 330                 335     
Thr Gly Met Val Gly Ala Leu Leu Leu Leu Leu Val Val Ala Leu Gly 
            340                 345                 350         
Ile Gly Leu Phe Met 
        355         

<210>  9
<211>  1180
<212>  DNA
<213>  人工序列(Artificial Sequence)

<400>  9
ggctccggtg cccgtcagtg ggcagagcgc acatcgccca cagtccccga gaagttgggg        60
ggaggggtcg gcaattgaac cggtgcctag agaaggtggc gcggggtaaa ctgggaaagt       120
gatgtcgtgt actggctccg cctttttccc gagggtgggg gagaaccgta tataagtgca       180
gtagtcgccg tgaacgttct ttttcgcaac gggtttgccg ccagaacaca ggtaagtgcc       240
gtgtgtggtt cccgcgggcc tggcctcttt acgggttatg gcccttgcgt gccttgaatt       300
acttccacct ggctgcagta cgtgattctt gatcccgagc ttcggggttg gaagtgggtg       360
ggagagttcg aggccttgcg cttaaggagc cccttcgcct cgtgcttgag ttgaggcctg       420
gcctgggcgc tggggccgcc gcgtgcgaat ctggtggcac cttcgcgcct gtctcgctgc       480
tttcgataag tctctagcca tttaaaattt ttgatgacct gctgcgacgc tttttttctg       540
gcaagatagt cttgtaaatg cgggccaaga tctgcacact ggtatttcgg tttttggggc       600
cgcgggcggc gacggggccc gtgcgtccca gcgcacatgt tcggcgaggc ggggcctgcg       660
agcgcggcca ccgagaatcg gacgggggta gtctcaagct ggccggcctg ctctggtgcc       720
tggcctcgcg ccgccgtgta tcgccccgcc ctgggcggca aggctggccc ggtcggcacc       780
agtagcgtga gcggaaagat ggccgcttcc cggccctgct gcagggagct caaaatggag       840
gacgcggcgc tcgggagagc gggcgggtga gtcacccaca caaaggaaaa gggcctttcc       900
gtcctcagcc gtcgcttcat gtgactccac ggagtaccgg gcgccgtcca ggcacctcga       960
ttagttctcg agcttttgga gtacgtcgtc tttaggttgg ggggaggggt tttatgcgat      1020
ggagtttccc cacactgagt gggtggagac tgaagttagg ccagcttggc acttgatgta      1080
attctccttg gaatttgccc tttttgagtt tggatcttgg ttcattctca agcctcagac      1140
agtggttcaa agtttttttc ttccatttca ggtgtcgtga                            1180

<210>  10
<211>  2550
<212>  DNA
<213>  人工序列(Artificial Sequence)

<400>  10
ttaattaagc caccatgctg ctgctggtga ccagcctgct gctgtgcgag ctgccccacc        60
ccgcctttct gctgatccga ggtgcagctg gtggagagcg gcggcggcct ggtgaagccc       120
ggcggcagcc tgaagctgag ctgcgccgcc agcggctaca ccttcaccag ctacgtgatg       180
cactgggtga gacaggcccc cggcaagggc ctggagtgga tcggctacat caacccctac       240
aacgacggca ccaagtacaa cgagaagttc cagggcagag tgaccatcag cagcgacaag       300
agcatcagca ccgcctacat ggagctgagc agcctgagaa gcgaggacac cgccatgtac       360
tactgcgcca gaggcaccta ctactacggc accagagtgt tcgactactg gggccagggc       420
accctggtga ccgtgagcag cggtggtggt ggttctggcg gcggcggctc cggtggtggt       480
ggttctgaca tcgtgatgac ccagagcccc gccaccctga gcctgagccc cggcgagaga       540
gccaccctga gctgcagaag cagcaagagc ctgcagaacg tgaacggcaa cacctacctg       600
tactggttcc agcagaagcc cggccagagc ccccagctgc tgatctacag aatgagcaac       660
ctgaacagcg gcgtgcccga cagattcagc ggcagcggca gcggcaccga gttcaccctg       720
accatcagca gcctggagcc cgaggacttc gccgtgtact actgcatgca gcacctggag       780
taccccatca ccttcggcgc cggcaccaag ctggagatca aggaatctaa gtacggaccg       840
ccctgccccc cttgccctat gttctgggtg ctggtggtgg tcggaggcgt gctggcctgc       900
tacagcctgc tggtcaccgt ggccttcatc atcttttggg tgaaacgggg cagaaagaaa       960
ctcctgtata tattcaaaca accatttatg agaccagtac aaactactca agaggaagat      1020
ggctgtagct gccgatttcc agaagaagaa gaaggaggat gtgaactgcg ggtgaagttc      1080
agcagaagcg ccgacgcccc tgcctaccag cagggccaga atcagctgta caacgagctg      1140
aacctgggca gaagggaaga gtacgacgtc ctggataagc ggagaggccg ggaccctgag      1200
atgggcggca agcctcggcg gaagaacccc caggaaggcc tgtataacga actgcagaaa      1260
gacaagatgg ccgaggccta cagcgagatc ggcatgaagg gcgagcggag gcggggcaag      1320
ggccacgacg gcctgtatca gggcctgtcc accgccacca aggataccta cgacgccctg      1380
cacatgcagg ccctgccccc aaggctcgag ggcggcggag agggcagagg aagtcttcta      1440
acatgcggtg acgtggagga gaatcccggc cctaggatgc ttctcctggt gacaagcctt      1500
ctgctctgtg agttaccaca cccagcattc ctcctgatcc cacgcaaagt gtgtaacgga      1560
ataggtattg gtgaatttaa agactcactc tccataaatg ctacgaatat taaacacttc      1620
aaaaactgca cctccatcag tggcgatctc cacatcctgc cggtggcatt taggggtgac      1680
tccttcacac atactcctcc tctggatcca caggaactgg atattctgaa aaccgtaaag      1740
gaaatcacag ggtttttgct gattcaggct tggcctgaaa acaggacgga cctccatgcc      1800
tttgagaacc tagaaatcat acgcggcagg accaagcaac atggtcagtt ttctcttgca      1860
gtcgtcagcc tgaacataac atccttggga ttacgctccc tcaaggagat aagtgatgga      1920
gatgtgataa tttcaggaaa caaaaatttg tgctatgcaa atacaataaa ctggaaaaaa      1980
ctgtttggga cctccggtca gaaaaccaaa attataagca acagaggtga aaacagctgc      2040
aaggccacag gccaggtctg ccatgccttg tgctcccccg agggctgctg gggcccggag      2100
cccagggact gcgtctcttg ccggaatgtc agccgaggca gggaatgcgt ggacaagtgc      2160
aaccttctgg agggtgagcc aagggagttt gtggagaact ctgagtgcat acagtgccac      2220
ccagagtgcc tgcctcaggc catgaacatc acctgcacag gacggggacc agacaactgt      2280
atccagtgtg cccactacat tgacggcccc cactgcgtca agacctgccc ggcaggagtc      2340
atgggagaaa acaacaccct ggtctggaag tacgcagacg ccggccatgt gtgccacctg      2400
tgccatccaa actgcaccta cggatgcact gggccaggtc ttgaaggctg tccaacgaat      2460
gggcctaaga tcccgtccat cgccactggg atggtggggg ccctcctctt gctgctggtg      2520
gtggccctgg ggatcggcct cttcatgtga                                       2550

<210>  11
<211>  735
<212>  DNA
<213>  人工序列(Artificial Sequence)

<400>  11
gacatccaga tgacccagac cacctccagc ctgagcgcca gcctgggcga ccgggtgacc        60
atcagctgcc gggccagcca ggacatcagc aagtacctga actggtatca gcagaagccc       120
gacggcaccg tcaagctgct gatctaccac accagccggc tgcacagcgg cgtgcccagc       180
cggtttagcg gcagcggctc cggcaccgac tacagcctga ccatctccaa cctggaacag       240
gaagatatcg ccacctactt ttgccagcag ggcaacacac tgccctacac ctttggcggc       300
ggaacaaagc tggaaatcac cggcagcacc tccggcagcg gcaagcctgg cagcggcgag       360
ggcagcacca agggcgaggt gaagctgcag gaaagcggcc ctggcctggt ggcccccagc       420
cagagcctga gcgtgacctg caccgtgagc ggcgtgagcc tgcccgacta cggcgtgagc       480
tggatccggc agccccccag gaagggcctg gaatggctgg gcgtgatctg gggcagcgag       540
accacctact acaacagcgc cctgaagagc cggctgacca tcatcaagga caacagcaag       600
agccaggtgt tcctgaagat gaacagcctg cagaccgacg acaccgccat ctactactgc       660
gccaagcact actactacgg cggcagctac gccatggact actggggcca gggcaccagc       720
gtgaccgtga gcagc                                                        735

<210>  12
<211>  245
<212>  PRT
<213>  人工序列(Artificial Sequence)

<400>  12
Asp Ile Gln Met Thr Gln Thr Thr Ser Ser Leu Ser Ala Ser Leu Gly 
1               5                   10                  15      
Asp Arg Val Thr Ile Ser Cys Arg Ala Ser Gln Asp Ile Ser Lys Tyr 
            20                  25                  30          
Leu Asn Trp Tyr Gln Gln Lys Pro Asp Gly Thr Val Lys Leu Leu Ile 
        35                  40                  45              
Tyr His Thr Ser Arg Leu His Ser Gly Val Pro Ser Arg Phe Ser Gly 
    50                  55                  60                  
Ser Gly Ser Gly Thr Asp Tyr Ser Leu Thr Ile Ser Asn Leu Glu Gln 
65                  70                  75                  80  
Glu Asp Ile Ala Thr Tyr Phe Cys Gln Gln Gly Asn Thr Leu Pro Tyr 
                85                  90                  95      
Thr Phe Gly Gly Gly Thr Lys Leu Glu Ile Thr Gly Ser Thr Ser Gly 
            100                 105                 110         
Ser Gly Lys Pro Gly Ser Gly Glu Gly Ser Thr Lys Gly Glu Val Lys 
        115                 120                 125             
Leu Gln Glu Ser Gly Pro Gly Leu Val Ala Pro Ser Gln Ser Leu Ser 
    130                 135                 140                 
Val Thr Cys Thr Val Ser Gly Val Ser Leu Pro Asp Tyr Gly Val Ser 
145                 150                 155                 160 
Trp Ile Arg Gln Pro Pro Arg Lys Gly Leu Glu Trp Leu Gly Val Ile 
                165                 170                 175     
Trp Gly Ser Glu Thr Thr Tyr Tyr Asn Ser Ala Leu Lys Ser Arg Leu 
            180                 185                 190         
Thr Ile Ile Lys Asp Asn Ser Lys Ser Gln Val Phe Leu Lys Met Asn 
        195                 200                 205             
Ser Leu Gln Thr Asp Asp Thr Ala Ile Tyr Tyr Cys Ala Lys His Tyr 
    210                 215                 220                 
Tyr Tyr Gly Gly Ser Tyr Ala Met Asp Tyr Trp Gly Gln Gly Thr Ser 
225                 230                 235                 240 
Val Thr Val Ser Ser 
                245 

<210>  13
<211>  9919
<212>  DNA
<213>  人工序列(Artificial Sequence)

<400>  13
actagtgtcg acaatcaacc tctggattac aaaatttgtg aaagattgac tggtattctt        60
aactatgttg ctccttttac gctatgtgga tacgctgctt taatgccttt gtatcatgct       120
attgcttccc gtatggcttt cattttctcc tccttgtata aatcctggtt gctgtctctt       180
tatgaggagt tgtggcccgt tgtcaggcaa cgtggcgtgg tgtgcactgt gtttgctgac       240
gcaaccccca ctggttgggg cattgccacc aactgtcagc tcctttccgg gactttcgct       300
ttccccctcc ctattgccac ggcggaactc atcgccgcct gccttgcccg ctgctggaca       360
ggggctcggc tgttgggcac tgacaattcc gtggtgttgt cggggaagct gacgtccttt       420
ccatggctgc tcgcctgtgt tgccacctgg attctgcgcg ggacgtcctt ctgctacgtc       480
ccttcggccc tcaatccagc ggaccttcct tcccgcggcc tgctgccggc tctgcggcct       540
cttccgcgtc ttcgccttcg ccctcagacg agtcggatct ccctttgggc cgcctccccg       600
cctggaattc gagctcggta cctttaagac caatgactta caaggcagct gtagatctta       660
gccacttttt aaaagaaaag gggggactgg aagggctaat tcactcccaa cgaagacaag       720
atctgctttt tgcttgtact gggtctctct ggttagacca gatctgagcc tgggagctct       780
ctggctaact agggaaccca ctgcttaagc ctcaataaag cttgccttga gtgcttcaag       840
tagtgtgtgc ccgtctgttg tgtgactctg gtaactagag atccctcaga cccttttagt       900
cagtgtggaa aatctctagc agtagtagtt catgtcatct tattattcag tatttataac       960
ttgcaaagaa atgaatatca gagagtgaga ggaacttgtt tattgcagct tataatggtt      1020
acaaataaag caatagcatc acaaatttca caaataaagc atttttttca ctgcattcta      1080
gttgtggttt gtccaaactc atcaatgtat cttatcatgt ctggctctag ctatcccgcc      1140
cctaactccg cccatcccgc ccctaactcc gcccagttcc gcccattctc cgccccatgg      1200
ctgactaatt ttttttattt atgcagaggc cgaggccgcc tcggcctctg agctattcca      1260
gaagtagtga ggaggctttt ttggaggcct agggacgtac ccaattcgcc ctatagtgag      1320
tcgtattacg cgcgctcact ggccgtcgtt ttacaacgtc gtgactggga aaaccctggc      1380
gttacccaac ttaatcgcct tgcagcacat ccccctttcg ccagctggcg taatagcgaa      1440
gaggcccgca ccgatcgccc ttcccaacag ttgcgcagcc tgaatggcga atgggacgcg      1500
ccctgtagcg gcgcattaag cgcggcgggt gtggtggtta cgcgcagcgt gaccgctaca      1560
cttgccagcg ccctagcgcc cgctcctttc gctttcttcc cttcctttct cgccacgttc      1620
gccggctttc cccgtcaagc tctaaatcgg gggctccctt tagggttccg atttagtgct      1680
ttacggcacc tcgaccccaa aaaacttgat tagggtgatg gttcacgtag tgggccatcg      1740
ccctgataga cggtttttcg ccctttgacg ttggagtcca cgttctttaa tagtggactc      1800
ttgttccaaa ctggaacaac actcaaccct atctcggtct attcttttga tttataaggg      1860
attttgccga tttcggccta ttggttaaaa aatgagctga tttaacaaaa atttaacgcg      1920
aattttaaca aaatattaac gcttacaatt taggtggcac ttttcgggga aatgtgcgcg      1980
gaacccctat ttgtttattt ttctaaatac attcaaatat gtatccgctc atgagacaat      2040
aaccctgata aatgcttcaa taatattgaa aaaggaagag tatgagtatt caacatttcc      2100
gtgtcgccct tattcccttt tttgcggcat tttgccttcc tgtttttgct cacccagaaa      2160
cgctggtgaa agtaaaagat gctgaagatc agttgggtgc acgagtgggt tacatcgaac      2220
tggatctcaa cagcggtaag atccttgaga gttttcgccc cgaagaacgt tttccaatga      2280
tgagcacttt taaagttctg ctatgtggcg cggtattatc ccgtattgac gccgggcaag      2340
agcaactcgg tcgccgcata cactattctc agaatgactt ggttgagtac tcaccagtca      2400
cagaaaagca tcttacggat ggcatgacag taagagaatt atgcagtgct gccataacca      2460
tgagtgataa cactgcggcc aacttacttc tgacaacgat cggaggaccg aaggagctaa      2520
ccgctttttt gcacaacatg ggggatcatg taactcgcct tgatcgttgg gaaccggagc      2580
tgaatgaagc cataccaaac gacgagcgtg acaccacgat gcctgtagca atggcaacaa      2640
cgttgcgcaa actattaact ggcgaactac ttactctagc ttcccggcaa caattaatag      2700
actggatgga ggcggataaa gttgcaggac cacttctgcg ctcggccctt ccggctggct      2760
ggtttattgc tgataaatct ggagccggtg agcgtgggtc tcgcggtatc attgcagcac      2820
tggggccaga tggtaagccc tcccgtatcg tagttatcta cacgacgggg agtcaggcaa      2880
ctatggatga acgaaataga cagatcgctg agataggtgc ctcactgatt aagcattggt      2940
aactgtcaga ccaagtttac tcatatatac tttagattga tttaaaactt catttttaat      3000
ttaaaaggat ctaggtgaag atcctttttg ataatctcat gaccaaaatc ccttaacgtg      3060
agttttcgtt ccactgagcg tcagaccccg tagaaaagat caaaggatct tcttgagatc      3120
ctttttttct gcgcgtaatc tgctgcttgc aaacaaaaaa accaccgcta ccagcggtgg      3180
tttgtttgcc ggatcaagag ctaccaactc tttttccgaa ggtaactggc ttcagcagag      3240
cgcagatacc aaatactgtt cttctagtgt agccgtagtt aggccaccac ttcaagaact      3300
ctgtagcacc gcctacatac ctcgctctgc taatcctgtt accagtggct gctgccagtg      3360
gcgataagtc gtgtcttacc gggttggact caagacgata gttaccggat aaggcgcagc      3420
ggtcgggctg aacggggggt tcgtgcacac agcccagctt ggagcgaacg acctacaccg      3480
aactgagata cctacagcgt gagctatgag aaagcgccac gcttcccgaa gggagaaagg      3540
cggacaggta tccggtaagc ggcagggtcg gaacaggaga gcgcacgagg gagcttccag      3600
ggggaaacgc ctggtatctt tatagtcctg tcgggtttcg ccacctctga cttgagcgtc      3660
gatttttgtg atgctcgtca ggggggcgga gcctatggaa aaacgccagc aacgcggcct      3720
ttttacggtt cctggccttt tgctggcctt ttgctcacat gttctttcct gcgttatccc      3780
ctgattctgt ggataaccgt attaccgcct ttgagtgagc tgataccgct cgccgcagcc      3840
gaacgaccga gcgcagcgag tcagtgagcg aggaagcgga agagcgccca atacgcaaac      3900
cgcctctccc cgcgcgttgg ccgattcatt aatgcagctg gcacgacagg tttcccgact      3960
ggaaagcggg cagtgagcgc aacgcaatta atgtgagtta gctcactcat taggcacccc      4020
aggctttaca ctttatgctt ccggctcgta tgttgtgtgg aattgtgagc ggataacaat      4080
ttcacacagg aaacagctat gaccatgatt acgccaagcg cgcaattaac cctcactaaa      4140
gggaacaaaa gctggagctg caagcttaat gtagtcttat gcaatactct tgtagtcttg      4200
caacatggta acgatgagtt agcaacatgc cttacaagga gagaaaaagc accgtgcatg      4260
ccgattggtg gaagtaaggt ggtacgatcg tgccttatta ggaaggcaac agacgggtct      4320
gacatggatt ggacgaacca ctgaattgcc gcattgcaga gatattgtat ttaagtgcct      4380
agctcgatac ataaacgggt ctctctggtt agaccagatc tgagcctggg agctctctgg      4440
ctaactaggg aacccactgc ttaagcctca ataaagcttg ccttgagtgc ttcaagtagt      4500
gtgtgcccgt ctgttgtgtg actctggtaa ctagagatcc ctcagaccct tttagtcagt      4560
gtggaaaatc tctagcagtg gcgcccgaac agggacttga aagcgaaagg gaaaccagag      4620
gagctctctc gacgcaggac tcggcttgct gaagcgcgca cggcaagagg cgaggggcgg      4680
cgactggtga gtacgccaaa aattttgact agcggaggct agaaggagag agatgggtgc      4740
gagagcgtca gtattaagcg ggggagaatt agatcgcgat gggaaaaaat tcggttaagg      4800
ccagggggaa agaaaaaata taaattaaaa catatagtat gggcaagcag ggagctagaa      4860
cgattcgcag ttaatcctgg cctgttagaa acatcagaag gctgtagaca aatactggga      4920
cagctacaac catcccttca gacaggatca gaagaactta gatcattata taatacagta      4980
gcaaccctct attgtgtgca tcaaaggata gagataaaag acaccaagga agctttagac      5040
aagatagagg aagagcaaaa caaaagtaag accaccgcac agcaagcggc cgctgatctt      5100
cagacctgga ggaggagata tgagggacaa ttggagaagt gaattatata aatataaagt      5160
agtaaaaatt gaaccattag gagtagcacc caccaaggca aagagaagag tggtgcagag      5220
agaaaaaaga gcagtgggaa taggagcttt gttccttggg ttcttgggag cagcaggaag      5280
cactatgggc gcagcgtcaa tgacgctgac ggtacaggcc agacaattat tgtctggtat      5340
agtgcagcag cagaacaatt tgctgagggc tattgaggcg caacagcatc tgttgcaact      5400
cacagtctgg ggcatcaagc agctccaggc aagaatcctg gctgtggaaa gatacctaaa      5460
ggatcaacag ctcctgggga tttggggttg ctctggaaaa ctcatttgca ccactgctgt      5520
gccttggaat gctagttgga gtaataaatc tctggaacag atttggaatc acacgacctg      5580
gatggagtgg gacagagaaa ttaacaatta cacaagctta atacactcct taattgaaga      5640
atcgcaaaac cagcaagaaa agaatgaaca agaattattg gaattagata aatgggcaag      5700
tttgtggaat tggtttaaca taacaaattg gctgtggtat ataaaattat tcataatgat      5760
agtaggaggc ttggtaggtt taagaatagt ttttgctgta ctttctatag tgaatagagt      5820
taggcaggga tattcaccat tatcgtttca gacccacctc ccaaccccga ggggacccga      5880
caggcccgaa ggaatagaag aagaaggtgg agagagagac agagacagat ccattcgatt      5940
agtgaacgga tctcgacggt atcggttaac ttttaaaaga aaagggggga ttggggggta      6000
cagtgcaggg gaaagaatag tagacataat agcaacagac atacaaacta aagaattaca      6060
aaaacaaatt acaaaaattc aaaattttat cgatgtcgac gataagcttt gcaaagatgg      6120
ataaagtttt aaacagagag gaatctttgc agctaatgga ccttctaggt cttgaaagga      6180
gtgggaattg gctccggtgc ccgtcagtgg gcagagcgca catcgcccac agtccccgag      6240
aagttggggg gaggggtcgg caattgaacc ggtgcctaga gaaggtggcg cggggtaaac      6300
tgggaaagtg atgtcgtgta ctggctccgc ctttttcccg agggtggggg agaaccgtat      6360
ataagtgcag tagtcgccgt gaacgttctt tttcgcaacg ggtttgccgc cagaacacag      6420
gtaagtgccg tgtgtggttc ccgcgggcct ggcctcttta cgggttatgg cccttgcgtg      6480
ccttgaatta cttccacctg gctgcagtac gtgattcttg atcccgagct tcggggttgg      6540
aagtgggtgg gagagttcga ggccttgcgc ttaaggagcc ccttcgcctc gtgcttgagt      6600
tgaggcctgg cctgggcgct ggggccgccg cgtgcgaatc tggtggcacc ttcgcgcctg      6660
tctcgctgct ttcgataagt ctctagccat ttaaaatttt tgatgacctg ctgcgacgct      6720
ttttttctgg caagatagtc ttgtaaatgc gggccaagat ctgcacactg gtatttcggt      6780
ttttggggcc gcgggcggcg acggggcccg tgcgtcccag cgcacatgtt cggcgaggcg      6840
gggcctgcga gcgcggccac cgagaatcgg acgggggtag tctcaagctg gccggcctgc      6900
tctggtgcct ggcctcgcgc cgccgtgtat cgccccgccc tgggcggcaa ggctggcccg      6960
gtcggcacca gtagcgtgag cggaaagatg gccgcttccc ggccctgctg cagggagctc      7020
aaaatggagg acgcggcgct cgggagagcg ggcgggtgag tcacccacac aaaggaaaag      7080
ggcctttccg tcctcagccg tcgcttcatg tgactccacg gagtaccggg cgccgtccag      7140
gcacctcgat tagttctcga gcttttggag tacgtcgtct ttaggttggg gggaggggtt      7200
ttatgcgatg gagtttcccc acactgagtg ggtggagact gaagttaggc cagcttggca      7260
cttgatgtaa ttctccttgg aatttgccct ttttgagttt ggatcttggt tcattctcaa      7320
gcctcagaca gtggttcaaa gtttttttct tccatttcag gtgtcgtgat taattaagcc      7380
accatgctgc tgctggtgac cagcctgctg ctgtgcgagc tgccccaccc cgcctttctg      7440
ctgatccgag gtgcagctgg tggagagcgg cggcggcctg gtgaagcccg gcggcagcct      7500
gaagctgagc tgcgccgcca gcggctacac cttcaccagc tacgtgatgc actgggtgag      7560
acaggccccc ggcaagggcc tggagtggat cggctacatc aacccctaca acgacggcac      7620
caagtacaac gagaagttcc agggcagagt gaccatcagc agcgacaaga gcatcagcac      7680
cgcctacatg gagctgagca gcctgagaag cgaggacacc gccatgtact actgcgccag      7740
aggcacctac tactacggca ccagagtgtt cgactactgg ggccagggca ccctggtgac      7800
cgtgagcagc ggtggtggtg gttctggcgg cggcggctcc ggtggtggtg gttctgacat      7860
cgtgatgacc cagagccccg ccaccctgag cctgagcccc ggcgagagag ccaccctgag      7920
ctgcagaagc agcaagagcc tgcagaacgt gaacggcaac acctacctgt actggttcca      7980
gcagaagccc ggccagagcc cccagctgct gatctacaga atgagcaacc tgaacagcgg      8040
cgtgcccgac agattcagcg gcagcggcag cggcaccgag ttcaccctga ccatcagcag      8100
cctggagccc gaggacttcg ccgtgtacta ctgcatgcag cacctggagt accccatcac      8160
cttcggcgcc ggcaccaagc tggagatcaa ggaatctaag tacggaccgc cctgcccccc      8220
ttgccctatg ttctgggtgc tggtggtggt cggaggcgtg ctggcctgct acagcctgct      8280
ggtcaccgtg gccttcatca tcttttgggt gaaacggggc agaaagaaac tcctgtatat      8340
attcaaacaa ccatttatga gaccagtaca aactactcaa gaggaagatg gctgtagctg      8400
ccgatttcca gaagaagaag aaggaggatg tgaactgcgg gtgaagttca gcagaagcgc      8460
cgacgcccct gcctaccagc agggccagaa tcagctgtac aacgagctga acctgggcag      8520
aagggaagag tacgacgtcc tggataagcg gagaggccgg gaccctgaga tgggcggcaa      8580
gcctcggcgg aagaaccccc aggaaggcct gtataacgaa ctgcagaaag acaagatggc      8640
cgaggcctac agcgagatcg gcatgaaggg cgagcggagg cggggcaagg gccacgacgg      8700
cctgtatcag ggcctgtcca ccgccaccaa ggatacctac gacgccctgc acatgcaggc      8760
cctgccccca aggctcgagg gcggcggaga gggcagagga agtcttctaa catgcggtga      8820
cgtggaggag aatcccggcc ctaggatgct tctcctggtg acaagccttc tgctctgtga      8880
gttaccacac ccagcattcc tcctgatccc acgcaaagtg tgtaacggaa taggtattgg      8940
tgaatttaaa gactcactct ccataaatgc tacgaatatt aaacacttca aaaactgcac      9000
ctccatcagt ggcgatctcc acatcctgcc ggtggcattt aggggtgact ccttcacaca      9060
tactcctcct ctggatccac aggaactgga tattctgaaa accgtaaagg aaatcacagg      9120
gtttttgctg attcaggctt ggcctgaaaa caggacggac ctccatgcct ttgagaacct      9180
agaaatcata cgcggcagga ccaagcaaca tggtcagttt tctcttgcag tcgtcagcct      9240
gaacataaca tccttgggat tacgctccct caaggagata agtgatggag atgtgataat      9300
ttcaggaaac aaaaatttgt gctatgcaaa tacaataaac tggaaaaaac tgtttgggac      9360
ctccggtcag aaaaccaaaa ttataagcaa cagaggtgaa aacagctgca aggccacagg      9420
ccaggtctgc catgccttgt gctcccccga gggctgctgg ggcccggagc ccagggactg      9480
cgtctcttgc cggaatgtca gccgaggcag ggaatgcgtg gacaagtgca accttctgga      9540
gggtgagcca agggagtttg tggagaactc tgagtgcata cagtgccacc cagagtgcct      9600
gcctcaggcc atgaacatca cctgcacagg acggggacca gacaactgta tccagtgtgc      9660
ccactacatt gacggccccc actgcgtcaa gacctgcccg gcaggagtca tgggagaaaa      9720
caacaccctg gtctggaagt acgcagacgc cggccatgtg tgccacctgt gccatccaaa      9780
ctgcacctac ggatgcactg ggccaggtct tgaaggctgt ccaacgaatg ggcctaagat      9840
cccgtccatc gccactggga tggtgggggc cctcctcttg ctgctggtgg tggccctggg      9900
gatcggcctc ttcatgtga                                                   9919

