                         SEQUENCE LISTING

<110>  UNIVERSITY OF SASKATCHEWAN
 
<120>  COMPOSITIONS AND METHODS FOR PREVENTING RSV AND PIV3 INFECTIONS

<130>  08945669WO

<140>  PCT/CA2022/050621
<141>  2022-04-22

<150>  US 63/178,287
<151>  2021-04-22

<160>  6     

<170>  PatentIn version 3.5

<210>  1
<211>  996
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  tFrSc6-HN Construct

<400>  1

Met Glu Leu Pro Ile Leu Lys Ala Asn Ala Ile Thr Thr Ile Leu Ala 
1               5                   10                  15      


Ala Val Thr Phe Cys Phe Ala Ser Ser Gln Asn Ile Thr Glu Glu Phe 
            20                  25                  30          


Tyr Gln Ser Thr Cys Ser Ala Val Ser Lys Gly Tyr Leu Ser Ala Leu 
        35                  40                  45              


Arg Thr Gly Trp Tyr Thr Ser Val Ile Thr Ile Glu Leu Ser Asn Ile 
    50                  55                  60                  


Lys Glu Asn Lys Cys Asn Gly Thr Asp Ala Lys Val Lys Leu Met Lys 
65                  70                  75                  80  


Gln Glu Leu Asp Lys Tyr Lys Asn Ala Val Thr Glu Leu Gln Leu Leu 
                85                  90                  95      


Met Gln Ser Thr Pro Ala Ala Asn Asn Gln Ala Arg Gly Ser Gly Ser 
            100                 105                 110         


Gly Arg Ser Leu Gly Phe Leu Leu Gly Val Gly Ser Ala Ile Ala Ser 
        115                 120                 125             


Gly Ile Ala Val Ser Lys Val Leu His Leu Glu Gly Glu Val Asn Lys 
    130                 135                 140                 


Ile Lys Ser Ala Leu Leu Ser Thr Asn Lys Ala Val Val Ser Leu Ser 
145                 150                 155                 160 


Asn Gly Val Ser Val Leu Thr Ser Lys Val Leu Asp Leu Lys Asn Tyr 
                165                 170                 175     


Ile Asp Lys Gln Leu Leu Pro Ile Val Asn Lys Gln Ser Cys Arg Ile 
            180                 185                 190         


Ser Asn Ile Glu Thr Val Ile Glu Phe Gln Gln Lys Asn Asn Arg Leu 
        195                 200                 205             


Leu Glu Ile Thr Arg Glu Phe Ser Val Asn Val Gly Val Thr Thr Pro 
    210                 215                 220                 


Val Ser Thr Tyr Met Leu Thr Asn Ser Glu Leu Leu Ser Leu Ile Asn 
225                 230                 235                 240 


Asp Met Pro Ile Thr Asn Asp Gln Lys Lys Leu Met Ser Asn Asn Val 
                245                 250                 255     


Gln Ile Val Arg Gln Gln Ser Tyr Ser Ile Met Ser Ile Ile Lys Glu 
            260                 265                 270         


Glu Val Leu Ala Tyr Val Val Gln Leu Pro Leu Tyr Gly Val Ile Asp 
        275                 280                 285             


Thr Pro Cys Trp Lys Leu His Thr Ser Pro Leu Cys Thr Thr Asn Thr 
    290                 295                 300                 


Lys Glu Gly Ser Asn Ile Cys Leu Thr Arg Thr Asp Arg Gly Trp Tyr 
305                 310                 315                 320 


Cys Asp Asn Ala Gly Ser Val Ser Phe Phe Pro Gln Ala Glu Thr Cys 
                325                 330                 335     


Lys Val Gln Ser Asn Arg Val Phe Cys Asp Thr Met Asn Ser Leu Thr 
            340                 345                 350         


Leu Pro Ser Glu Val Asn Leu Cys Asn Val Asp Ile Phe Asn Pro Lys 
        355                 360                 365             


Tyr Asp Cys Lys Ile Met Thr Ser Lys Thr Asp Val Ser Ser Ser Val 
    370                 375                 380                 


Ile Thr Ser Leu Gly Ala Ile Val Ser Cys Tyr Gly Lys Thr Lys Cys 
385                 390                 395                 400 


Thr Ala Ser Asn Lys Asn Arg Gly Ile Ile Lys Thr Phe Ser Asn Gly 
                405                 410                 415     


Cys Asp Tyr Val Ser Asn Lys Gly Val Asp Thr Val Ser Val Gly Asn 
            420                 425                 430         


Thr Leu Tyr Tyr Val Asn Lys Gln Glu Gly Lys Ser Leu Tyr Val Lys 
        435                 440                 445             


Gly Glu Pro Ile Ile Asn Phe Tyr Asp Pro Leu Val Phe Pro Ser Asp 
    450                 455                 460                 


Glu Phe Asp Ala Ser Ile Ser Gln Val Asn Glu Lys Ile Asn Gln Ser 
465                 470                 475                 480 


Leu Ala Phe Ile Arg Lys Ser Asp Glu Leu Leu Gly Ser Thr Asn Asp 
                485                 490                 495     


Leu Ile Gln Ser Gly Val Asn Thr Arg Leu Leu Thr Ile Gln Ser His 
            500                 505                 510         


Val Gln Asn Tyr Ile Pro Ile Ser Leu Thr Gln Gln Met Ser Asp Leu 
        515                 520                 525             


Arg Lys Phe Ile Ser Glu Ile Thr Ile Arg Asn Asp Asn Gln Glu Val 
    530                 535                 540                 


Leu Pro Gln Arg Ile Thr His Asp Val Gly Ile Lys Pro Leu Asn Pro 
545                 550                 555                 560 


Asp Asp Phe Trp Arg Cys Thr Ser Gly Leu Pro Ser Leu Met Lys Thr 
                565                 570                 575     


Pro Lys Ile Arg Leu Met Pro Gly Pro Gly Leu Leu Ala Met Pro Thr 
            580                 585                 590         


Thr Val Asp Gly Cys Val Arg Thr Pro Ser Leu Val Ile Asn Asp Leu 
        595                 600                 605             


Ile Tyr Ala Tyr Thr Ser Asn Leu Ile Thr Arg Gly Cys Gln Asp Ile 
    610                 615                 620                 


Gly Lys Ser Tyr Gln Val Leu Gln Ile Gly Ile Ile Thr Val Asn Ser 
625                 630                 635                 640 


Asp Leu Val Pro Asp Leu Asn Pro Arg Ile Ser His Thr Phe Asn Ile 
                645                 650                 655     


Asn Asp Asn Arg Lys Ser Cys Ser Leu Ala Leu Leu Asn Thr Asp Val 
            660                 665                 670         


Tyr Gln Leu Cys Ser Thr Pro Lys Val Asp Glu Arg Ser Asp Tyr Ala 
        675                 680                 685             


Ser Ser Gly Ile Glu Asp Ile Val Leu Asp Ile Val Asn Tyr Asp Gly 
    690                 695                 700                 


Ser Ile Ser Thr Thr Arg Phe Lys Asn Asn Asn Ile Ser Phe Asp Gln 
705                 710                 715                 720 


Pro Tyr Ala Ala Leu Tyr Pro Ser Val Gly Pro Gly Ile Tyr Tyr Lys 
                725                 730                 735     


Gly Lys Ile Ile Phe Leu Gly Tyr Gly Gly Leu Glu His Pro Ile Asn 
            740                 745                 750         


Glu Asn Val Ile Cys Asn Thr Thr Gly Cys Pro Gly Lys Thr Gln Arg 
        755                 760                 765             


Asp Cys Asn Gln Ala Ser His Ser Pro Trp Phe Ser Asp Arg Arg Met 
    770                 775                 780                 


Val Asn Ser Ile Ile Val Val Asp Lys Gly Leu Asn Ser Ile Pro Lys 
785                 790                 795                 800 


Leu Lys Val Trp Thr Ile Ser Met Arg Gln Asn Tyr Trp Gly Ser Glu 
                805                 810                 815     


Gly Arg Leu Leu Leu Leu Gly Asn Lys Ile Tyr Ile Tyr Thr Arg Ser 
            820                 825                 830         


Thr Ser Trp His Ser Lys Leu Gln Leu Gly Ile Ile Asp Ile Thr Asp 
        835                 840                 845             


Tyr Ser Asp Ile Arg Ile Lys Trp Thr Trp His Asn Val Leu Ser Arg 
    850                 855                 860                 


Pro Gly Asn Asn Glu Cys Pro Trp Gly His Ser Cys Pro Asp Gly Cys 
865                 870                 875                 880 


Ile Thr Gly Val Tyr Thr Asp Ala Tyr Pro Leu Asn Pro Thr Gly Ser 
                885                 890                 895     


Ile Val Ser Ser Val Ile Leu Asp Ser Gln Lys Ser Arg Val Asn Pro 
            900                 905                 910         


Val Ile Thr Tyr Ser Thr Ala Thr Glu Arg Val Asn Glu Leu Ala Ile 
        915                 920                 925             


Leu Asn Arg Thr Leu Ser Ala Gly Tyr Thr Thr Thr Ser Cys Ile Thr 
    930                 935                 940                 


His Tyr Asn Lys Gly Tyr Cys Phe His Ile Val Glu Ile Asn His Lys 
945                 950                 955                 960 


Ser Leu Asn Thr Phe Gln Pro Met Leu Phe Lys Thr Glu Ile Pro Lys 
                965                 970                 975     


Ser Cys Ser Gly Ser Gly Ser Gly His His His His His His His His 
            980                 985                 990         


His His His His 
        995     


<210>  2
<211>  2991
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  tFrSc6-HN Construct

<400>  2

Ala Thr Gly Gly Ala Gly Cys Thr Gly Cys Cys Thr Ala Thr Cys Cys 
1               5                   10                  15      


Thr Gly Ala Ala Gly Gly Cys Cys Ala Ala Cys Gly Cys Cys Ala Thr 
            20                  25                  30          


Cys Ala Cys Cys Ala Cys Ala Ala Thr Thr Cys Thr Gly Gly Cys Cys 
        35                  40                  45              


Gly Cys Cys Gly Thr Gly Ala Cys Cys Thr Thr Cys Thr Gly Thr Thr 
    50                  55                  60                  


Thr Thr Gly Cys Cys Ala Gly Cys Ala Gly Cys Cys Ala Gly Ala Ala 
65                  70                  75                  80  


Cys Ala Thr Cys Ala Cys Cys Gly Ala Gly Gly Ala Gly Thr Thr Cys 
                85                  90                  95      


Thr Ala Cys Cys Ala Gly Ala Gly Cys Ala Cys Cys Thr Gly Thr Ala 
            100                 105                 110         


Gly Cys Gly Cys Cys Gly Thr Gly Ala Gly Cys Ala Ala Gly Gly Gly 
        115                 120                 125             


Cys Thr Ala Thr Cys Thr Gly Ala Gly Cys Gly Cys Cys Cys Thr Gly 
    130                 135                 140                 


Ala Gly Ala Ala Cys Cys Gly Gly Cys Thr Gly Gly Thr Ala Cys Ala 
145                 150                 155                 160 


Cys Cys Ala Gly Cys Gly Thr Gly Ala Thr Cys Ala Cys Cys Ala Thr 
                165                 170                 175     


Cys Gly Ala Gly Cys Thr Gly Ala Gly Cys Ala Ala Cys Ala Thr Cys 
            180                 185                 190         


Ala Ala Gly Gly Ala Gly Ala Ala Cys Ala Ala Gly Thr Gly Cys Ala 
        195                 200                 205             


Ala Cys Gly Gly Cys Ala Cys Cys Gly Ala Cys Gly Cys Cys Ala Ala 
    210                 215                 220                 


Gly Gly Thr Gly Ala Ala Gly Cys Thr Gly Ala Thr Gly Ala Ala Gly 
225                 230                 235                 240 


Cys Ala Gly Gly Ala Gly Cys Thr Gly Gly Ala Cys Ala Ala Gly Thr 
                245                 250                 255     


Ala Cys Ala Ala Gly Ala Ala Cys Gly Cys Cys Gly Thr Gly Ala Cys 
            260                 265                 270         


Cys Gly Ala Ala Cys Thr Gly Cys Ala Gly Cys Thr Gly Cys Thr Gly 
        275                 280                 285             


Ala Thr Gly Cys Ala Gly Thr Cys Thr Ala Cys Cys Cys Cys Thr Gly 
    290                 295                 300                 


Cys Cys Gly Cys Cys Ala Ala Cys Ala Ala Cys Cys Ala Gly Gly Cys 
305                 310                 315                 320 


Gly Ala Gly Ala Gly Gly Cys Ala Gly Cys Gly Gly Cys Thr Cys Thr 
                325                 330                 335     


Gly Gly Cys Ala Gly Ala Ala Gly Cys Cys Thr Gly Gly Gly Cys Thr 
            340                 345                 350         


Thr Thr Cys Thr Gly Cys Thr Gly Gly Gly Ala Gly Thr Gly Gly Gly 
        355                 360                 365             


Cys Thr Cys Thr Gly Cys Cys Ala Thr Cys Gly Cys Cys Thr Cys Thr 
    370                 375                 380                 


Gly Gly Cys Ala Thr Cys Gly Cys Cys Gly Thr Gly Thr Cys Thr Ala 
385                 390                 395                 400 


Ala Gly Gly Thr Gly Cys Thr Gly Cys Ala Cys Cys Thr Gly Gly Ala 
                405                 410                 415     


Gly Gly Gly Ala Gly Ala Gly Gly Thr Gly Ala Ala Cys Ala Ala Gly 
            420                 425                 430         


Ala Thr Cys Ala Ala Gly Ala Gly Cys Gly Cys Cys Cys Thr Gly Cys 
        435                 440                 445             


Thr Gly Ala Gly Cys Ala Cys Cys Ala Ala Thr Ala Ala Gly Gly Cys 
    450                 455                 460                 


Cys Gly Thr Gly Gly Thr Gly Ala Gly Cys Cys Thr Gly Ala Gly Cys 
465                 470                 475                 480 


Ala Ala Thr Gly Gly Cys Gly Thr Gly Ala Gly Cys Gly Thr Gly Cys 
                485                 490                 495     


Thr Gly Ala Cys Ala Ala Gly Cys Ala Ala Gly Gly Thr Gly Cys Thr 
            500                 505                 510         


Gly Gly Ala Cys Cys Thr Cys Ala Ala Gly Ala Ala Cys Thr Ala Cys 
        515                 520                 525             


Ala Thr Cys Gly Ala Cys Ala Ala Gly Cys Ala Gly Cys Thr Gly Cys 
    530                 535                 540                 


Thr Gly Cys Cys Cys Ala Thr Cys Gly Thr Gly Ala Ala Cys Ala Ala 
545                 550                 555                 560 


Gly Cys Ala Gly Ala Gly Cys Thr Gly Cys Cys Gly Gly Ala Thr Cys 
                565                 570                 575     


Ala Gly Cys Ala Ala Cys Ala Thr Cys Gly Ala Gly Ala Cys Cys Gly 
            580                 585                 590         


Thr Gly Ala Thr Cys Gly Ala Gly Thr Thr Cys Cys Ala Gly Cys Ala 
        595                 600                 605             


Gly Ala Ala Gly Ala Ala Cys Ala Ala Cys Cys Gly Gly Cys Thr Gly 
    610                 615                 620                 


Cys Thr Gly Gly Ala Gly Ala Thr Cys Ala Cys Cys Ala Gly Gly Gly 
625                 630                 635                 640 


Ala Gly Thr Thr Cys Ala Gly Cys Gly Thr Gly Ala Ala Thr Gly Thr 
                645                 650                 655     


Gly Gly Gly Cys Gly Thr Gly Ala Cys Cys Ala Cys Cys Cys Cys Thr 
            660                 665                 670         


Gly Thr Gly Ala Gly Cys Ala Cys Cys Thr Ala Cys Ala Thr Gly Cys 
        675                 680                 685             


Thr Gly Ala Cys Cys Ala Ala Cys Ala Gly Cys Gly Ala Gly Cys Thr 
    690                 695                 700                 


Gly Cys Thr Gly Ala Gly Cys Cys Thr Gly Ala Thr Cys Ala Ala Cys 
705                 710                 715                 720 


Gly Ala Cys Ala Thr Gly Cys Cys Cys Ala Thr Cys Ala Cys Cys Ala 
                725                 730                 735     


Ala Cys Gly Ala Cys Cys Ala Gly Ala Ala Gly Ala Ala Gly Cys Thr 
            740                 745                 750         


Gly Ala Thr Gly Thr Cys Cys Ala Ala Cys Ala Ala Cys Gly Thr Gly 
        755                 760                 765             


Cys Ala Gly Ala Thr Cys Gly Thr Gly Cys Gly Gly Cys Ala Gly Cys 
    770                 775                 780                 


Ala Gly Ala Gly Cys Thr Ala Cys Ala Gly Cys Ala Thr Cys Ala Thr 
785                 790                 795                 800 


Gly Thr Cys Cys Ala Thr Cys Ala Thr Cys Ala Ala Gly Gly Ala Gly 
                805                 810                 815     


Gly Ala Gly Gly Thr Gly Cys Thr Gly Gly Cys Thr Thr Ala Cys Gly 
            820                 825                 830         


Thr Gly Gly Thr Gly Cys Ala Gly Cys Thr Gly Cys Cys Thr Cys Thr 
        835                 840                 845             


Gly Thr Ala Cys Gly Gly Cys Gly Thr Gly Ala Thr Cys Gly Ala Cys 
    850                 855                 860                 


Ala Cys Cys Cys Cys Thr Thr Gly Cys Thr Gly Gly Ala Ala Gly Cys 
865                 870                 875                 880 


Thr Gly Cys Ala Cys Ala Cys Cys Ala Gly Cys Cys Cys Thr Cys Thr 
                885                 890                 895     


Gly Thr Gly Cys Ala Cys Cys Ala Cys Cys Ala Ala Thr Ala Cys Cys 
            900                 905                 910         


Ala Ala Gly Gly Ala Gly Gly Gly Cys Ala Gly Cys Ala Ala Cys Ala 
        915                 920                 925             


Thr Cys Thr Gly Cys Cys Thr Gly Ala Cys Cys Ala Gly Gly Ala Cys 
    930                 935                 940                 


Cys Gly Ala Thr Ala Gly Ala Gly Gly Cys Thr Gly Gly Thr Ala Cys 
945                 950                 955                 960 


Thr Gly Cys Gly Ala Cys Ala Ala Thr Gly Cys Cys Gly Gly Cys Ala 
                965                 970                 975     


Gly Cys Gly Thr Gly Ala Gly Cys Thr Thr Cys Thr Thr Thr Cys Cys 
            980                 985                 990         


Ala Cys Ala Gly Gly Cys Cys Gly  Ala Gly Ala Cys Cys  Thr Gly Thr 
        995                 1000                 1005             


Ala Ala  Gly Gly Thr Gly Cys  Ala Gly Ala Gly Cys  Ala Ala Cys 
    1010                 1015                 1020             


Cys Gly  Gly Gly Thr Gly Thr  Thr Cys Thr Gly Cys  Gly Ala Cys 
    1025                 1030                 1035             


Ala Cys  Cys Ala Thr Gly Ala  Ala Cys Ala Gly Cys  Cys Thr Gly 
    1040                 1045                 1050             


Ala Cys  Cys Cys Thr Gly Cys  Cys Thr Thr Cys Thr  Gly Ala Gly 
    1055                 1060                 1065             


Gly Thr  Gly Ala Ala Cys Cys  Thr Gly Thr Gly Cys  Ala Ala Cys 
    1070                 1075                 1080             


Gly Thr  Gly Gly Ala Cys Ala  Thr Cys Thr Thr Cys  Ala Ala Cys 
    1085                 1090                 1095             


Cys Cys  Cys Ala Ala Gly Thr  Ala Cys Gly Ala Cys  Thr Gly Cys 
    1100                 1105                 1110             


Ala Ala  Gly Ala Thr Cys Ala  Thr Gly Ala Cys Cys  Ala Gly Cys 
    1115                 1120                 1125             


Ala Ala  Gly Ala Cys Cys Gly  Ala Cys Gly Thr Gly  Ala Gly Cys 
    1130                 1135                 1140             


Ala Gly  Cys Ala Gly Cys Gly  Thr Gly Ala Thr Thr  Ala Cys Ala 
    1145                 1150                 1155             


Ala Gly  Cys Cys Thr Gly Gly  Gly Cys Gly Cys Cys  Ala Thr Cys 
    1160                 1165                 1170             


Gly Thr  Gly Ala Gly Cys Thr  Gly Thr Thr Ala Cys  Gly Gly Cys 
    1175                 1180                 1185             


Ala Ala  Gly Ala Cys Cys Ala  Ala Gly Thr Gly Cys  Ala Cys Cys 
    1190                 1195                 1200             


Gly Cys  Cys Ala Gly Cys Ala  Ala Cys Ala Ala Gly  Ala Ala Cys 
    1205                 1210                 1215             


Cys Gly  Cys Gly Gly Cys Ala  Thr Cys Ala Thr Cys  Ala Ala Gly 
    1220                 1225                 1230             


Ala Cys  Cys Thr Thr Cys Ala  Gly Cys Ala Ala Cys  Gly Gly Cys 
    1235                 1240                 1245             


Thr Gly  Cys Gly Ala Cys Thr  Ala Cys Gly Thr Gly  Ala Gly Cys 
    1250                 1255                 1260             


Ala Ala  Cys Ala Ala Gly Gly  Gly Cys Gly Thr Gly  Gly Ala Thr 
    1265                 1270                 1275             


Ala Cys  Ala Gly Thr Gly Ala  Gly Cys Gly Thr Gly  Gly Gly Cys 
    1280                 1285                 1290             


Ala Ala  Cys Ala Cys Cys Cys  Thr Gly Thr Ala Cys  Thr Ala Cys 
    1295                 1300                 1305             


Gly Thr  Cys Ala Ala Cys Ala  Ala Gly Cys Ala Gly  Gly Ala Gly 
    1310                 1315                 1320             


Gly Gly  Cys Ala Ala Gly Ala  Gly Cys Cys Thr Gly  Thr Ala Cys 
    1325                 1330                 1335             


Gly Thr  Gly Ala Ala Gly Gly  Gly Cys Gly Ala Gly  Cys Cys Cys 
    1340                 1345                 1350             


Ala Thr  Cys Ala Thr Cys Ala  Ala Cys Thr Thr Cys  Thr Ala Cys 
    1355                 1360                 1365             


Gly Ala  Cys Cys Cys Cys Cys  Thr Gly Gly Thr Gly  Thr Thr Cys 
    1370                 1375                 1380             


Cys Cys  Thr Ala Gly Cys Gly  Ala Cys Gly Ala Gly  Thr Thr Cys 
    1385                 1390                 1395             


Gly Ala  Thr Gly Cys Cys Ala  Gly Cys Ala Thr Cys  Ala Gly Cys 
    1400                 1405                 1410             


Cys Ala  Gly Gly Thr Gly Ala  Ala Cys Gly Ala Gly  Ala Ala Gly 
    1415                 1420                 1425             


Ala Thr  Cys Ala Ala Cys Cys  Ala Gly Ala Gly Cys  Cys Thr Gly 
    1430                 1435                 1440             


Gly Cys  Cys Thr Thr Cys Ala  Thr Cys Ala Gly Gly  Ala Ala Gly 
    1445                 1450                 1455             


Ala Gly  Cys Gly Ala Cys Gly  Ala Gly Cys Thr Gly  Cys Thr Gly 
    1460                 1465                 1470             


Gly Gly  Ala Thr Cys Cys Ala  Cys Thr Ala Ala Cys  Gly Ala Cys 
    1475                 1480                 1485             


Cys Thr  Gly Ala Thr Cys Cys  Ala Gly Thr Cys Thr  Gly Gly Cys 
    1490                 1495                 1500             


Gly Thr  Gly Ala Ala Cys Ala  Cys Ala Ala Gly Gly  Cys Thr Gly 
    1505                 1510                 1515             


Cys Thr  Gly Ala Cys Thr Ala  Thr Thr Cys Ala Gly  Ala Gly Cys 
    1520                 1525                 1530             


Cys Ala  Cys Gly Thr Cys Cys  Ala Gly Ala Ala Thr  Thr Ala Cys 
    1535                 1540                 1545             


Ala Thr  Cys Cys Cys Ala Ala  Thr Thr Thr Cys Cys  Cys Thr Gly 
    1550                 1555                 1560             


Ala Cys  Ala Cys Ala Gly Cys  Ala Gly Ala Thr Gly  Thr Cys Thr 
    1565                 1570                 1575             


Gly Ala  Cys Cys Thr Gly Ala  Gly Gly Ala Ala Gly  Thr Thr Cys 
    1580                 1585                 1590             


Ala Thr  Cys Thr Cys Cys Gly  Ala Ala Ala Thr Cys  Ala Cys Thr 
    1595                 1600                 1605             


Ala Thr  Thr Cys Gly Cys Ala  Ala Thr Gly Ala Thr  Ala Ala Cys 
    1610                 1615                 1620             


Cys Ala  Gly Gly Ala Gly Gly  Thr Gly Cys Thr Gly  Cys Cys Cys 
    1625                 1630                 1635             


Cys Ala  Gly Cys Gly Cys Ala  Thr Cys Ala Cys Cys  Cys Ala Thr 
    1640                 1645                 1650             


Gly Ala  Cys Gly Thr Gly Gly  Gly Cys Ala Thr Cys  Ala Ala Gly 
    1655                 1660                 1665             


Cys Cys  Ala Cys Thr Gly Ala  Ala Cys Cys Cys Cys  Gly Ala Cys 
    1670                 1675                 1680             


Gly Ala  Thr Thr Thr Thr Thr  Gly Gly Ala Gly Gly  Thr Gly Cys 
    1685                 1690                 1695             


Ala Cys  Thr Thr Cys Ala Gly  Gly Ala Cys Thr Gly  Cys Cys Thr 
    1700                 1705                 1710             


Ala Gly  Cys Cys Thr Gly Ala  Thr Gly Ala Ala Gly  Ala Cys Cys 
    1715                 1720                 1725             


Cys Cys  Ala Ala Ala Ala Ala  Thr Cys Cys Gly Ala  Cys Thr Gly 
    1730                 1735                 1740             


Ala Thr  Gly Cys Cys Ala Gly  Gly Ala Cys Cys Thr  Gly Gly Ala 
    1745                 1750                 1755             


Cys Thr  Gly Cys Thr Gly Gly  Cys Ala Ala Thr Gly  Cys Cys Ala 
    1760                 1765                 1770             


Ala Cys  Cys Ala Cys Ala Gly  Thr Gly Gly Ala Thr  Gly Gly Ala 
    1775                 1780                 1785             


Thr Gly  Cys Gly Thr Cys Cys  Gly Ala Ala Cys Cys  Cys Cys Cys 
    1790                 1795                 1800             


Thr Cys  Thr Cys Thr Gly Gly  Thr Cys Ala Thr Cys  Ala Ala Cys 
    1805                 1810                 1815             


Gly Ala  Cys Cys Thr Gly Ala  Thr Cys Thr Ala Cys  Gly Cys Cys 
    1820                 1825                 1830             


Thr Ala  Thr Ala Cys Thr Ala  Gly Thr Ala Ala Thr  Cys Thr Gly 
    1835                 1840                 1845             


Ala Thr  Cys Ala Cys Cys Cys  Gly Cys Gly Gly Cys  Thr Gly Thr 
    1850                 1855                 1860             


Cys Ala  Gly Gly Ala Cys Ala  Thr Thr Gly Gly Gly  Ala Ala Gly 
    1865                 1870                 1875             


Thr Cys  Cys Thr Ala Cys Cys  Ala Gly Gly Thr Gly  Cys Thr Gly 
    1880                 1885                 1890             


Cys Ala  Gly Ala Thr Cys Gly  Gly Cys Ala Thr Cys  Ala Thr Thr 
    1895                 1900                 1905             


Ala Cys  Ala Gly Thr Gly Ala  Ala Cys Ala Gly Thr  Gly Ala Thr 
    1910                 1915                 1920             


Cys Thr  Gly Gly Thr Cys Cys  Cys Cys Gly Ala Cys  Cys Thr Gly 
    1925                 1930                 1935             


Ala Ala  Thr Cys Cys Thr Cys  Gly Cys Ala Thr Cys  Thr Cys Ala 
    1940                 1945                 1950             


Cys Ala  Cys Ala Cys Thr Thr  Thr Thr Ala Ala Thr  Ala Thr Cys 
    1955                 1960                 1965             


Ala Ala  Cys Gly Ala Thr Ala  Ala Cys Cys Gly Ala  Ala Ala Gly 
    1970                 1975                 1980             


Thr Cys  Ala Thr Gly Cys Ala  Gly Cys Cys Thr Gly  Gly Cys Thr 
    1985                 1990                 1995             


Cys Thr  Gly Cys Thr Gly Ala  Ala Cys Ala Cys Ala  Gly Ala Cys 
    2000                 2005                 2010             


Gly Thr  Gly Thr Ala Cys Cys  Ala Gly Cys Thr Gly  Thr Gly Cys 
    2015                 2020                 2025             


Thr Cys  Thr Ala Cys Thr Cys  Cys Thr Ala Ala Ala  Gly Thr Cys 
    2030                 2035                 2040             


Gly Ala  Thr Gly Ala Ala Cys  Gly Gly Ala Gly Thr  Gly Ala Cys 
    2045                 2050                 2055             


Thr Ala  Thr Gly Cys Ala Ala  Gly Cys Thr Cys Cys  Gly Gly Cys 
    2060                 2065                 2070             


Ala Thr  Cys Gly Ala Gly Gly  Ala Thr Ala Thr Thr  Gly Thr Gly 
    2075                 2080                 2085             


Cys Thr  Gly Gly Ala Cys Ala  Thr Cys Gly Thr Cys  Ala Ala Thr 
    2090                 2095                 2100             


Thr Ala  Cys Gly Ala Thr Gly  Gly Gly Thr Cys Cys  Ala Thr Thr 
    2105                 2110                 2115             


Thr Cys  Thr Ala Cys Thr Ala  Cys Cys Ala Gly Ala  Thr Thr Cys 
    2120                 2125                 2130             


Ala Ala  Gly Ala Ala Cys Ala  Ala Thr Ala Ala Cys  Ala Thr Cys 
    2135                 2140                 2145             


Ala Gly  Cys Thr Thr Thr Gly  Ala Cys Cys Ala Gly  Cys Cys Cys 
    2150                 2155                 2160             


Thr Ala  Cys Gly Cys Cys Gly  Cys Thr Cys Thr Gly  Thr Ala Thr 
    2165                 2170                 2175             


Cys Cys  Ala Thr Cys Cys Gly  Thr Gly Gly Gly Ala  Cys Cys Ala 
    2180                 2185                 2190             


Gly Gly  Ala Ala Thr Cys Thr  Ala Cys Thr Ala Cys  Ala Ala Gly 
    2195                 2200                 2205             


Gly Gly  Ala Ala Ala Ala Ala  Thr Cys Ala Thr Thr  Thr Thr Cys 
    2210                 2215                 2220             


Cys Thr  Gly Gly Gly Cys Thr  Ala Thr Gly Gly Cys  Gly Gly Gly 
    2225                 2230                 2235             


Cys Thr  Gly Gly Ala Ala Cys  Ala Cys Cys Cys Thr  Ala Thr Cys 
    2240                 2245                 2250             


Ala Ala  Cys Gly Ala Gly Ala  Ala Thr Gly Thr Gly  Ala Thr Thr 
    2255                 2260                 2265             


Thr Gly  Cys Ala Ala Cys Ala  Cys Ala Ala Cys Thr  Gly Gly Cys 
    2270                 2275                 2280             


Thr Gly  Thr Cys Cys Ala Gly  Gly Gly Ala Ala Gly  Ala Cys Cys 
    2285                 2290                 2295             


Cys Ala  Gly Ala Gly Gly Gly  Ala Thr Thr Gly Cys  Ala Ala Thr 
    2300                 2305                 2310             


Cys Ala  Gly Gly Cys Cys Ala  Gly Thr Cys Ala Thr  Thr Cys Ala 
    2315                 2320                 2325             


Cys Cys  Cys Thr Gly Gly Thr  Thr Thr Ala Gly Thr  Gly Ala Thr 
    2330                 2335                 2340             


Cys Gly  Gly Ala Gly Ala Ala  Thr Gly Gly Thr Gly  Ala Ala Cys 
    2345                 2350                 2355             


Thr Cys  Ala Ala Thr Cys Ala  Thr Thr Gly Thr Gly  Gly Thr Cys 
    2360                 2365                 2370             


Gly Ala  Cys Ala Ala Ala Gly  Gly Gly Cys Thr Gly  Ala Ala Thr 
    2375                 2380                 2385             


Ala Gly  Cys Ala Thr Cys Cys  Cys Thr Ala Ala Gly  Cys Thr Gly 
    2390                 2395                 2400             


Ala Ala  Ala Gly Thr Cys Thr  Gly Gly Ala Cys Cys  Ala Thr Thr 
    2405                 2410                 2415             


Thr Cys  Ala Ala Thr Gly Cys  Gly Ala Cys Ala Gly  Ala Ala Cys 
    2420                 2425                 2430             


Thr Ala  Cys Thr Gly Gly Gly  Gly Ala Ala Gly Cys  Gly Ala Ala 
    2435                 2440                 2445             


Gly Gly  Cys Cys Gly Gly Cys  Thr Gly Cys Thr Gly  Cys Thr Gly 
    2450                 2455                 2460             


Cys Thr  Gly Gly Gly Cys Ala  Ala Thr Ala Ala Gly  Ala Thr Cys 
    2465                 2470                 2475             


Thr Ala  Cys Ala Thr Cys Thr  Ala Cys Ala Cys Thr  Cys Gly Gly 
    2480                 2485                 2490             


Ala Gly  Cys Ala Cys Cys Thr  Cys Cys Thr Gly Gly  Cys Ala Cys 
    2495                 2500                 2505             


Thr Cys  Cys Ala Ala Ala Cys  Thr Gly Cys Ala Gly  Cys Thr Gly 
    2510                 2515                 2520             


Gly Gly  Gly Ala Thr Cys Ala  Thr Thr Gly Ala Cys  Ala Thr Cys 
    2525                 2530                 2535             


Ala Cys  Cys Gly Ala Thr Thr  Ala Thr Thr Cys Thr  Gly Ala Cys 
    2540                 2545                 2550             


Ala Thr  Cys Cys Gly Gly Ala  Thr Thr Ala Ala Gly  Thr Gly Gly 
    2555                 2560                 2565             


Ala Cys  Ala Thr Gly Gly Cys  Ala Cys Ala Ala Cys  Gly Thr Gly 
    2570                 2575                 2580             


Cys Thr  Gly Thr Cys Ala Ala  Gly Ala Cys Cys Cys  Gly Gly Gly 
    2585                 2590                 2595             


Ala Ala  Thr Ala Ala Cys Gly  Ala Gly Thr Gly Thr  Cys Cys Thr 
    2600                 2605                 2610             


Thr Gly  Gly Gly Gly Ala Cys  Ala Thr Ala Gly Cys  Thr Gly Cys 
    2615                 2620                 2625             


Cys Cys  Ala Gly Ala Thr Gly  Gly Gly Thr Gly Thr  Ala Thr Cys 
    2630                 2635                 2640             


Ala Cys  Cys Gly Gly Ala Gly  Thr Gly Thr Ala Cys  Ala Cys Ala 
    2645                 2650                 2655             


Gly Ala  Cys Gly Cys Thr Thr  Ala Thr Cys Cys Thr  Cys Thr Gly 
    2660                 2665                 2670             


Ala Ala  Cys Cys Cys Ala Ala  Cys Cys Gly Gly Cys  Ala Gly Thr 
    2675                 2680                 2685             


Ala Thr  Cys Gly Thr Gly Thr  Cys Thr Ala Gly Thr  Gly Thr Cys 
    2690                 2695                 2700             


Ala Thr  Thr Cys Thr Gly Gly  Ala Cys Thr Cys Thr  Cys Ala Gly 
    2705                 2710                 2715             


Ala Ala  Ala Ala Gly Thr Ala  Gly Ala Gly Thr Gly  Ala Ala Thr 
    2720                 2725                 2730             


Cys Cys  Cys Gly Thr Cys Ala  Thr Cys Ala Cys Ala  Thr Ala Cys 
    2735                 2740                 2745             


Ala Gly  Cys Ala Cys Cys Gly  Cys Ala Ala Cys Ala  Gly Ala Ala 
    2750                 2755                 2760             


Ala Gly  Ala Gly Thr Gly Ala  Ala Cys Gly Ala Gly  Cys Thr Gly 
    2765                 2770                 2775             


Gly Cys  Cys Ala Thr Thr Cys  Thr Gly Ala Ala Thr  Ala Gly Gly 
    2780                 2785                 2790             


Ala Cys  Thr Cys Thr Gly Ala  Gly Cys Gly Cys Cys  Gly Gly Ala 
    2795                 2800                 2805             


Thr Ala  Thr Ala Cys Cys Ala  Cys Ala Ala Cys Thr  Thr Cys Cys 
    2810                 2815                 2820             


Thr Gly  Cys Ala Thr Cys Ala  Cys Cys Cys Ala Thr  Thr Ala Cys 
    2825                 2830                 2835             


Ala Ala  Cys Ala Ala Gly Gly  Gly Cys Thr Ala Thr  Thr Gly Thr 
    2840                 2845                 2850             


Thr Thr  Cys Cys Ala Cys Ala  Thr Cys Gly Thr Gly  Gly Ala Ala 
    2855                 2860                 2865             


Ala Thr  Thr Ala Ala Cys Cys  Ala Thr Ala Ala Ala  Ala Gly Cys 
    2870                 2875                 2880             


Cys Thr  Gly Ala Ala Thr Ala  Cys Cys Thr Thr Cys  Cys Ala Gly 
    2885                 2890                 2895             


Cys Cys  Cys Ala Thr Gly Cys  Thr Gly Thr Thr Thr  Ala Ala Gly 
    2900                 2905                 2910             


Ala Cys  Ala Gly Ala Gly Ala  Thr Thr Cys Cys Thr  Ala Ala Ala 
    2915                 2920                 2925             


Ala Gly  Thr Thr Gly Thr Thr  Cys Ala Gly Gly Cys  Ala Gly Thr 
    2930                 2935                 2940             


Gly Gly  Gly Thr Cys Ala Gly  Gly Ala Cys Ala Thr  Cys Ala Cys 
    2945                 2950                 2955             


Cys Ala  Thr Cys Ala Thr Cys  Ala Thr Cys Ala Thr  Cys Ala Thr 
    2960                 2965                 2970             


Cys Ala  Cys Cys Ala Thr Cys  Ala Thr Cys Ala Cys  Cys Ala Thr 
    2975                 2980                 2985             


Thr Gly  Ala 
    2990     


<210>  3
<211>  996
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  tFrSc8-HN Construct

<400>  3

Met Glu Leu Pro Ile Leu Lys Ala Asn Ala Ile Thr Thr Ile Leu Ala 
1               5                   10                  15      


Ala Val Thr Phe Cys Phe Ala Ser Ser Gln Asn Ile Thr Glu Glu Phe 
            20                  25                  30          


Tyr Gln Ser Thr Cys Ser Ala Val Ser Lys Gly Tyr Leu Ser Ala Leu 
        35                  40                  45              


Arg Thr Gly Trp Tyr Thr Ser Val Ile Thr Ile Glu Leu Ser Asn Ile 
    50                  55                  60                  


Lys Glu Asn Lys Cys Asn Gly Thr Asp Ala Lys Val Lys Leu Met Lys 
65                  70                  75                  80  


Gln Glu Leu Asp Lys Tyr Lys Asn Ala Val Thr Glu Leu Gln Leu Leu 
                85                  90                  95      


Met Gln Ser Thr Pro Ala Ala Asn Asn Arg Ala Arg Gly Ser Gly Ser 
            100                 105                 110         


Gly Arg Thr Leu Gly Phe Leu Leu Gly Val Gly Ser Ala Ile Ala Ser 
        115                 120                 125             


Gly Ile Ala Val Ser Lys Val Leu His Leu Glu Gly Glu Val Asn Lys 
    130                 135                 140                 


Ile Lys Ser Ala Leu Leu Ser Thr Asn Lys Ala Val Val Ser Leu Ser 
145                 150                 155                 160 


Asn Gly Val Ser Val Leu Thr Ser Lys Val Leu Asp Leu Lys Asn Tyr 
                165                 170                 175     


Ile Asp Lys Gln Leu Leu Pro Ile Val Asn Lys Gln Ser Cys Arg Ile 
            180                 185                 190         


Ser Asn Ile Glu Thr Val Ile Glu Phe Gln Gln Lys Asn Asn Arg Leu 
        195                 200                 205             


Leu Glu Ile Thr Arg Glu Phe Ser Val Asn Val Gly Val Thr Thr Pro 
    210                 215                 220                 


Val Ser Thr Tyr Met Leu Thr Asn Ser Glu Leu Leu Ser Leu Ile Asn 
225                 230                 235                 240 


Asp Met Pro Ile Thr Asn Asp Gln Lys Lys Leu Met Ser Asn Asn Val 
                245                 250                 255     


Gln Ile Val Arg Gln Gln Ser Tyr Ser Ile Met Ser Ile Ile Lys Glu 
            260                 265                 270         


Glu Val Leu Ala Tyr Val Val Gln Leu Pro Leu Tyr Gly Val Ile Asp 
        275                 280                 285             


Thr Pro Cys Trp Lys Leu His Thr Ser Pro Leu Cys Thr Thr Asn Thr 
    290                 295                 300                 


Lys Glu Gly Ser Asn Ile Cys Leu Thr Arg Thr Asp Arg Gly Trp Tyr 
305                 310                 315                 320 


Cys Asp Asn Ala Gly Ser Val Ser Phe Phe Pro Gln Ala Glu Thr Cys 
                325                 330                 335     


Lys Val Gln Ser Asn Arg Val Phe Cys Asp Thr Met Asn Ser Leu Thr 
            340                 345                 350         


Leu Pro Ser Glu Val Asn Leu Cys Asn Val Asp Ile Phe Asn Pro Lys 
        355                 360                 365             


Tyr Asp Cys Lys Ile Met Thr Ser Lys Thr Asp Val Ser Ser Ser Val 
    370                 375                 380                 


Ile Thr Ser Leu Gly Ala Ile Val Ser Cys Tyr Gly Lys Thr Lys Cys 
385                 390                 395                 400 


Thr Ala Ser Asn Lys Asn Arg Gly Ile Ile Lys Thr Phe Ser Asn Gly 
                405                 410                 415     


Cys Asp Tyr Val Ser Asn Lys Gly Val Asp Thr Val Ser Val Gly Asn 
            420                 425                 430         


Thr Leu Tyr Tyr Val Asn Lys Gln Glu Gly Lys Ser Leu Tyr Val Lys 
        435                 440                 445             


Gly Glu Pro Ile Ile Asn Phe Tyr Asp Pro Leu Val Phe Pro Ser Asp 
    450                 455                 460                 


Glu Phe Asp Ala Ser Ile Ser Gln Val Asn Glu Lys Ile Asn Gln Ser 
465                 470                 475                 480 


Leu Ala Phe Ile Arg Lys Ser Asp Glu Leu Leu Gly Ser Thr Asn Asp 
                485                 490                 495     


Leu Ile Gln Ser Gly Val Asn Thr Arg Leu Leu Thr Ile Gln Ser His 
            500                 505                 510         


Val Gln Asn Tyr Ile Pro Ile Ser Leu Thr Gln Gln Met Ser Asp Leu 
        515                 520                 525             


Arg Lys Phe Ile Ser Glu Ile Thr Ile Arg Asn Asp Asn Gln Glu Val 
    530                 535                 540                 


Leu Pro Gln Arg Ile Thr His Asp Val Gly Ile Lys Pro Leu Asn Pro 
545                 550                 555                 560 


Asp Asp Phe Trp Arg Cys Thr Ser Gly Leu Pro Ser Leu Met Lys Thr 
                565                 570                 575     


Pro Lys Ile Arg Leu Met Pro Gly Pro Gly Leu Leu Ala Met Pro Thr 
            580                 585                 590         


Thr Val Asp Gly Cys Val Arg Thr Pro Ser Leu Val Ile Asn Asp Leu 
        595                 600                 605             


Ile Tyr Ala Tyr Thr Ser Asn Leu Ile Thr Arg Gly Cys Gln Asp Ile 
    610                 615                 620                 


Gly Lys Ser Tyr Gln Val Leu Gln Ile Gly Ile Ile Thr Val Asn Ser 
625                 630                 635                 640 


Asp Leu Val Pro Asp Leu Asn Pro Arg Ile Ser His Thr Phe Asn Ile 
                645                 650                 655     


Asn Asp Asn Arg Lys Ser Cys Ser Leu Ala Leu Leu Asn Thr Asp Val 
            660                 665                 670         


Tyr Gln Leu Cys Ser Thr Pro Lys Val Asp Glu Arg Ser Asp Tyr Ala 
        675                 680                 685             


Ser Ser Gly Ile Glu Asp Ile Val Leu Asp Ile Val Asn Tyr Asp Gly 
    690                 695                 700                 


Ser Ile Ser Thr Thr Arg Phe Lys Asn Asn Asn Ile Ser Phe Asp Gln 
705                 710                 715                 720 


Pro Tyr Ala Ala Leu Tyr Pro Ser Val Gly Pro Gly Ile Tyr Tyr Lys 
                725                 730                 735     


Gly Lys Ile Ile Phe Leu Gly Tyr Gly Gly Leu Glu His Pro Ile Asn 
            740                 745                 750         


Glu Asn Val Ile Cys Asn Thr Thr Gly Cys Pro Gly Lys Thr Gln Arg 
        755                 760                 765             


Asp Cys Asn Gln Ala Ser His Ser Pro Trp Phe Ser Asp Arg Arg Met 
    770                 775                 780                 


Val Asn Ser Ile Ile Val Val Asp Lys Gly Leu Asn Ser Ile Pro Lys 
785                 790                 795                 800 


Leu Lys Val Trp Thr Ile Ser Met Arg Gln Asn Tyr Trp Gly Ser Glu 
                805                 810                 815     


Gly Arg Leu Leu Leu Leu Gly Asn Lys Ile Tyr Ile Tyr Thr Arg Ser 
            820                 825                 830         


Thr Ser Trp His Ser Lys Leu Gln Leu Gly Ile Ile Asp Ile Thr Asp 
        835                 840                 845             


Tyr Ser Asp Ile Arg Ile Lys Trp Thr Trp His Asn Val Leu Ser Arg 
    850                 855                 860                 


Pro Gly Asn Asn Glu Cys Pro Trp Gly His Ser Cys Pro Asp Gly Cys 
865                 870                 875                 880 


Ile Thr Gly Val Tyr Thr Asp Ala Tyr Pro Leu Asn Pro Thr Gly Ser 
                885                 890                 895     


Ile Val Ser Ser Val Ile Leu Asp Ser Gln Lys Ser Arg Val Asn Pro 
            900                 905                 910         


Val Ile Thr Tyr Ser Thr Ala Thr Glu Arg Val Asn Glu Leu Ala Ile 
        915                 920                 925             


Leu Asn Arg Thr Leu Ser Ala Gly Tyr Thr Thr Thr Ser Cys Ile Thr 
    930                 935                 940                 


His Tyr Asn Lys Gly Tyr Cys Phe His Ile Val Glu Ile Asn His Lys 
945                 950                 955                 960 


Ser Leu Asn Thr Phe Gln Pro Met Leu Phe Lys Thr Glu Ile Pro Lys 
                965                 970                 975     


Ser Cys Ser Gly Ser Gly Ser Gly His His His His His His His His 
            980                 985                 990         


His His His His 
        995     


<210>  4
<211>  2991
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  tFrSc8-HN Construct

<400>  4

Ala Thr Gly Gly Ala Gly Cys Thr Gly Cys Cys Thr Ala Thr Cys Cys 
1               5                   10                  15      


Thr Gly Ala Ala Gly Gly Cys Cys Ala Ala Cys Gly Cys Cys Ala Thr 
            20                  25                  30          


Cys Ala Cys Cys Ala Cys Ala Ala Thr Thr Cys Thr Gly Gly Cys Cys 
        35                  40                  45              


Gly Cys Cys Gly Thr Gly Ala Cys Cys Thr Thr Cys Thr Gly Thr Thr 
    50                  55                  60                  


Thr Thr Gly Cys Cys Ala Gly Cys Ala Gly Cys Cys Ala Gly Ala Ala 
65                  70                  75                  80  


Cys Ala Thr Cys Ala Cys Cys Gly Ala Gly Gly Ala Gly Thr Thr Cys 
                85                  90                  95      


Thr Ala Cys Cys Ala Gly Ala Gly Cys Ala Cys Cys Thr Gly Thr Ala 
            100                 105                 110         


Gly Cys Gly Cys Cys Gly Thr Gly Ala Gly Cys Ala Ala Gly Gly Gly 
        115                 120                 125             


Cys Thr Ala Thr Cys Thr Gly Ala Gly Cys Gly Cys Cys Cys Thr Gly 
    130                 135                 140                 


Ala Gly Ala Ala Cys Cys Gly Gly Cys Thr Gly Gly Thr Ala Cys Ala 
145                 150                 155                 160 


Cys Cys Ala Gly Cys Gly Thr Gly Ala Thr Cys Ala Cys Cys Ala Thr 
                165                 170                 175     


Cys Gly Ala Gly Cys Thr Gly Ala Gly Cys Ala Ala Cys Ala Thr Cys 
            180                 185                 190         


Ala Ala Gly Gly Ala Gly Ala Ala Cys Ala Ala Gly Thr Gly Cys Ala 
        195                 200                 205             


Ala Cys Gly Gly Cys Ala Cys Cys Gly Ala Cys Gly Cys Cys Ala Ala 
    210                 215                 220                 


Gly Gly Thr Gly Ala Ala Gly Cys Thr Gly Ala Thr Gly Ala Ala Gly 
225                 230                 235                 240 


Cys Ala Gly Gly Ala Gly Cys Thr Gly Gly Ala Cys Ala Ala Gly Thr 
                245                 250                 255     


Ala Cys Ala Ala Gly Ala Ala Cys Gly Cys Cys Gly Thr Gly Ala Cys 
            260                 265                 270         


Cys Gly Ala Ala Cys Thr Gly Cys Ala Gly Cys Thr Gly Cys Thr Gly 
        275                 280                 285             


Ala Thr Gly Cys Ala Gly Thr Cys Thr Ala Cys Cys Cys Cys Thr Gly 
    290                 295                 300                 


Cys Cys Gly Cys Cys Ala Ala Cys Ala Ala Cys Ala Gly Ala Gly Cys 
305                 310                 315                 320 


Cys Ala Gly Ala Gly Gly Cys Ala Gly Cys Gly Gly Cys Ala Gly Cys 
                325                 330                 335     


Gly Gly Cys Ala Gly Ala Ala Cys Cys Cys Thr Gly Gly Gly Cys Thr 
            340                 345                 350         


Thr Thr Cys Thr Gly Cys Thr Gly Gly Gly Ala Gly Thr Gly Gly Gly 
        355                 360                 365             


Cys Thr Cys Thr Gly Cys Cys Ala Thr Cys Gly Cys Cys Thr Cys Thr 
    370                 375                 380                 


Gly Gly Cys Ala Thr Cys Gly Cys Cys Gly Thr Gly Thr Cys Thr Ala 
385                 390                 395                 400 


Ala Gly Gly Thr Gly Cys Thr Gly Cys Ala Cys Cys Thr Gly Gly Ala 
                405                 410                 415     


Gly Gly Gly Ala Gly Ala Gly Gly Thr Gly Ala Ala Cys Ala Ala Gly 
            420                 425                 430         


Ala Thr Cys Ala Ala Gly Ala Gly Cys Gly Cys Cys Cys Thr Gly Cys 
        435                 440                 445             


Thr Gly Ala Gly Cys Ala Cys Cys Ala Ala Thr Ala Ala Gly Gly Cys 
    450                 455                 460                 


Cys Gly Thr Gly Gly Thr Gly Ala Gly Cys Cys Thr Gly Ala Gly Cys 
465                 470                 475                 480 


Ala Ala Thr Gly Gly Cys Gly Thr Gly Ala Gly Cys Gly Thr Gly Cys 
                485                 490                 495     


Thr Gly Ala Cys Ala Ala Gly Cys Ala Ala Gly Gly Thr Gly Cys Thr 
            500                 505                 510         


Gly Gly Ala Cys Cys Thr Cys Ala Ala Gly Ala Ala Cys Thr Ala Cys 
        515                 520                 525             


Ala Thr Cys Gly Ala Cys Ala Ala Gly Cys Ala Gly Cys Thr Gly Cys 
    530                 535                 540                 


Thr Gly Cys Cys Cys Ala Thr Cys Gly Thr Gly Ala Ala Cys Ala Ala 
545                 550                 555                 560 


Gly Cys Ala Gly Ala Gly Cys Thr Gly Cys Cys Gly Gly Ala Thr Cys 
                565                 570                 575     


Ala Gly Cys Ala Ala Cys Ala Thr Cys Gly Ala Gly Ala Cys Cys Gly 
            580                 585                 590         


Thr Gly Ala Thr Cys Gly Ala Gly Thr Thr Cys Cys Ala Gly Cys Ala 
        595                 600                 605             


Gly Ala Ala Gly Ala Ala Cys Ala Ala Cys Cys Gly Gly Cys Thr Gly 
    610                 615                 620                 


Cys Thr Gly Gly Ala Gly Ala Thr Cys Ala Cys Cys Ala Gly Gly Gly 
625                 630                 635                 640 


Ala Gly Thr Thr Cys Ala Gly Cys Gly Thr Gly Ala Ala Thr Gly Thr 
                645                 650                 655     


Gly Gly Gly Cys Gly Thr Gly Ala Cys Cys Ala Cys Cys Cys Cys Thr 
            660                 665                 670         


Gly Thr Gly Ala Gly Cys Ala Cys Cys Thr Ala Cys Ala Thr Gly Cys 
        675                 680                 685             


Thr Gly Ala Cys Cys Ala Ala Cys Ala Gly Cys Gly Ala Gly Cys Thr 
    690                 695                 700                 


Gly Cys Thr Gly Ala Gly Cys Cys Thr Gly Ala Thr Cys Ala Ala Cys 
705                 710                 715                 720 


Gly Ala Cys Ala Thr Gly Cys Cys Cys Ala Thr Cys Ala Cys Cys Ala 
                725                 730                 735     


Ala Cys Gly Ala Cys Cys Ala Gly Ala Ala Gly Ala Ala Gly Cys Thr 
            740                 745                 750         


Gly Ala Thr Gly Thr Cys Cys Ala Ala Cys Ala Ala Cys Gly Thr Gly 
        755                 760                 765             


Cys Ala Gly Ala Thr Cys Gly Thr Gly Cys Gly Gly Cys Ala Gly Cys 
    770                 775                 780                 


Ala Gly Ala Gly Cys Thr Ala Cys Ala Gly Cys Ala Thr Cys Ala Thr 
785                 790                 795                 800 


Gly Thr Cys Cys Ala Thr Cys Ala Thr Cys Ala Ala Gly Gly Ala Gly 
                805                 810                 815     


Gly Ala Gly Gly Thr Gly Cys Thr Gly Gly Cys Thr Thr Ala Cys Gly 
            820                 825                 830         


Thr Gly Gly Thr Gly Cys Ala Gly Cys Thr Gly Cys Cys Thr Cys Thr 
        835                 840                 845             


Gly Thr Ala Cys Gly Gly Cys Gly Thr Gly Ala Thr Cys Gly Ala Cys 
    850                 855                 860                 


Ala Cys Cys Cys Cys Thr Thr Gly Cys Thr Gly Gly Ala Ala Gly Cys 
865                 870                 875                 880 


Thr Gly Cys Ala Cys Ala Cys Cys Ala Gly Cys Cys Cys Thr Cys Thr 
                885                 890                 895     


Gly Thr Gly Cys Ala Cys Cys Ala Cys Cys Ala Ala Thr Ala Cys Cys 
            900                 905                 910         


Ala Ala Gly Gly Ala Gly Gly Gly Cys Ala Gly Cys Ala Ala Cys Ala 
        915                 920                 925             


Thr Cys Thr Gly Cys Cys Thr Gly Ala Cys Cys Ala Gly Gly Ala Cys 
    930                 935                 940                 


Cys Gly Ala Thr Ala Gly Ala Gly Gly Cys Thr Gly Gly Thr Ala Cys 
945                 950                 955                 960 


Thr Gly Cys Gly Ala Cys Ala Ala Thr Gly Cys Cys Gly Gly Cys Ala 
                965                 970                 975     


Gly Cys Gly Thr Gly Ala Gly Cys Thr Thr Cys Thr Thr Thr Cys Cys 
            980                 985                 990         


Ala Cys Ala Gly Gly Cys Cys Gly  Ala Gly Ala Cys Cys  Thr Gly Thr 
        995                 1000                 1005             


Ala Ala  Gly Gly Thr Gly Cys  Ala Gly Ala Gly Cys  Ala Ala Cys 
    1010                 1015                 1020             


Cys Gly  Gly Gly Thr Gly Thr  Thr Cys Thr Gly Cys  Gly Ala Cys 
    1025                 1030                 1035             


Ala Cys  Cys Ala Thr Gly Ala  Ala Cys Ala Gly Cys  Cys Thr Gly 
    1040                 1045                 1050             


Ala Cys  Cys Cys Thr Gly Cys  Cys Thr Thr Cys Thr  Gly Ala Gly 
    1055                 1060                 1065             


Gly Thr  Gly Ala Ala Cys Cys  Thr Gly Thr Gly Cys  Ala Ala Cys 
    1070                 1075                 1080             


Gly Thr  Gly Gly Ala Cys Ala  Thr Cys Thr Thr Cys  Ala Ala Cys 
    1085                 1090                 1095             


Cys Cys  Cys Ala Ala Gly Thr  Ala Cys Gly Ala Cys  Thr Gly Cys 
    1100                 1105                 1110             


Ala Ala  Gly Ala Thr Cys Ala  Thr Gly Ala Cys Cys  Ala Gly Cys 
    1115                 1120                 1125             


Ala Ala  Gly Ala Cys Cys Gly  Ala Cys Gly Thr Gly  Ala Gly Cys 
    1130                 1135                 1140             


Ala Gly  Cys Ala Gly Cys Gly  Thr Gly Ala Thr Thr  Ala Cys Ala 
    1145                 1150                 1155             


Ala Gly  Cys Cys Thr Gly Gly  Gly Cys Gly Cys Cys  Ala Thr Cys 
    1160                 1165                 1170             


Gly Thr  Gly Ala Gly Cys Thr  Gly Thr Thr Ala Cys  Gly Gly Cys 
    1175                 1180                 1185             


Ala Ala  Gly Ala Cys Cys Ala  Ala Gly Thr Gly Cys  Ala Cys Cys 
    1190                 1195                 1200             


Gly Cys  Cys Ala Gly Cys Ala  Ala Cys Ala Ala Gly  Ala Ala Cys 
    1205                 1210                 1215             


Cys Gly  Cys Gly Gly Cys Ala  Thr Cys Ala Thr Cys  Ala Ala Gly 
    1220                 1225                 1230             


Ala Cys  Cys Thr Thr Cys Ala  Gly Cys Ala Ala Cys  Gly Gly Cys 
    1235                 1240                 1245             


Thr Gly  Cys Gly Ala Cys Thr  Ala Cys Gly Thr Gly  Ala Gly Cys 
    1250                 1255                 1260             


Ala Ala  Cys Ala Ala Gly Gly  Gly Cys Gly Thr Gly  Gly Ala Thr 
    1265                 1270                 1275             


Ala Cys  Ala Gly Thr Gly Ala  Gly Cys Gly Thr Gly  Gly Gly Cys 
    1280                 1285                 1290             


Ala Ala  Cys Ala Cys Cys Cys  Thr Gly Thr Ala Cys  Thr Ala Cys 
    1295                 1300                 1305             


Gly Thr  Cys Ala Ala Cys Ala  Ala Gly Cys Ala Gly  Gly Ala Gly 
    1310                 1315                 1320             


Gly Gly  Cys Ala Ala Gly Ala  Gly Cys Cys Thr Gly  Thr Ala Cys 
    1325                 1330                 1335             


Gly Thr  Gly Ala Ala Gly Gly  Gly Cys Gly Ala Gly  Cys Cys Cys 
    1340                 1345                 1350             


Ala Thr  Cys Ala Thr Cys Ala  Ala Cys Thr Thr Cys  Thr Ala Cys 
    1355                 1360                 1365             


Gly Ala  Cys Cys Cys Cys Cys  Thr Gly Gly Thr Gly  Thr Thr Cys 
    1370                 1375                 1380             


Cys Cys  Thr Ala Gly Cys Gly  Ala Cys Gly Ala Gly  Thr Thr Cys 
    1385                 1390                 1395             


Gly Ala  Thr Gly Cys Cys Ala  Gly Cys Ala Thr Cys  Ala Gly Cys 
    1400                 1405                 1410             


Cys Ala  Gly Gly Thr Gly Ala  Ala Cys Gly Ala Gly  Ala Ala Gly 
    1415                 1420                 1425             


Ala Thr  Cys Ala Ala Cys Cys  Ala Gly Ala Gly Cys  Cys Thr Gly 
    1430                 1435                 1440             


Gly Cys  Cys Thr Thr Cys Ala  Thr Cys Ala Gly Gly  Ala Ala Gly 
    1445                 1450                 1455             


Ala Gly  Cys Gly Ala Cys Gly  Ala Gly Cys Thr Gly  Cys Thr Gly 
    1460                 1465                 1470             


Gly Gly  Ala Thr Cys Cys Ala  Cys Thr Ala Ala Cys  Gly Ala Cys 
    1475                 1480                 1485             


Cys Thr  Gly Ala Thr Cys Cys  Ala Gly Thr Cys Thr  Gly Gly Cys 
    1490                 1495                 1500             


Gly Thr  Gly Ala Ala Cys Ala  Cys Ala Ala Gly Gly  Cys Thr Gly 
    1505                 1510                 1515             


Cys Thr  Gly Ala Cys Thr Ala  Thr Thr Cys Ala Gly  Ala Gly Cys 
    1520                 1525                 1530             


Cys Ala  Cys Gly Thr Cys Cys  Ala Gly Ala Ala Thr  Thr Ala Cys 
    1535                 1540                 1545             


Ala Thr  Cys Cys Cys Ala Ala  Thr Thr Thr Cys Cys  Cys Thr Gly 
    1550                 1555                 1560             


Ala Cys  Ala Cys Ala Gly Cys  Ala Gly Ala Thr Gly  Thr Cys Thr 
    1565                 1570                 1575             


Gly Ala  Cys Cys Thr Gly Ala  Gly Gly Ala Ala Gly  Thr Thr Cys 
    1580                 1585                 1590             


Ala Thr  Cys Thr Cys Cys Gly  Ala Ala Ala Thr Cys  Ala Cys Thr 
    1595                 1600                 1605             


Ala Thr  Thr Cys Gly Cys Ala  Ala Thr Gly Ala Thr  Ala Ala Cys 
    1610                 1615                 1620             


Cys Ala  Gly Gly Ala Gly Gly  Thr Gly Cys Thr Gly  Cys Cys Cys 
    1625                 1630                 1635             


Cys Ala  Gly Cys Gly Cys Ala  Thr Cys Ala Cys Cys  Cys Ala Thr 
    1640                 1645                 1650             


Gly Ala  Cys Gly Thr Gly Gly  Gly Cys Ala Thr Cys  Ala Ala Gly 
    1655                 1660                 1665             


Cys Cys  Ala Cys Thr Gly Ala  Ala Cys Cys Cys Cys  Gly Ala Cys 
    1670                 1675                 1680             


Gly Ala  Thr Thr Thr Thr Thr  Gly Gly Ala Gly Gly  Thr Gly Cys 
    1685                 1690                 1695             


Ala Cys  Thr Thr Cys Ala Gly  Gly Ala Cys Thr Gly  Cys Cys Thr 
    1700                 1705                 1710             


Ala Gly  Cys Cys Thr Gly Ala  Thr Gly Ala Ala Gly  Ala Cys Cys 
    1715                 1720                 1725             


Cys Cys  Ala Ala Ala Ala Ala  Thr Cys Cys Gly Ala  Cys Thr Gly 
    1730                 1735                 1740             


Ala Thr  Gly Cys Cys Ala Gly  Gly Ala Cys Cys Thr  Gly Gly Ala 
    1745                 1750                 1755             


Cys Thr  Gly Cys Thr Gly Gly  Cys Ala Ala Thr Gly  Cys Cys Ala 
    1760                 1765                 1770             


Ala Cys  Cys Ala Cys Ala Gly  Thr Gly Gly Ala Thr  Gly Gly Ala 
    1775                 1780                 1785             


Thr Gly  Cys Gly Thr Cys Cys  Gly Ala Ala Cys Cys  Cys Cys Cys 
    1790                 1795                 1800             


Thr Cys  Thr Cys Thr Gly Gly  Thr Cys Ala Thr Cys  Ala Ala Cys 
    1805                 1810                 1815             


Gly Ala  Cys Cys Thr Gly Ala  Thr Cys Thr Ala Cys  Gly Cys Cys 
    1820                 1825                 1830             


Thr Ala  Thr Ala Cys Thr Ala  Gly Thr Ala Ala Thr  Cys Thr Gly 
    1835                 1840                 1845             


Ala Thr  Cys Ala Cys Cys Cys  Gly Cys Gly Gly Cys  Thr Gly Thr 
    1850                 1855                 1860             


Cys Ala  Gly Gly Ala Cys Ala  Thr Thr Gly Gly Gly  Ala Ala Gly 
    1865                 1870                 1875             


Thr Cys  Cys Thr Ala Cys Cys  Ala Gly Gly Thr Gly  Cys Thr Gly 
    1880                 1885                 1890             


Cys Ala  Gly Ala Thr Cys Gly  Gly Cys Ala Thr Cys  Ala Thr Thr 
    1895                 1900                 1905             


Ala Cys  Ala Gly Thr Gly Ala  Ala Cys Ala Gly Thr  Gly Ala Thr 
    1910                 1915                 1920             


Cys Thr  Gly Gly Thr Cys Cys  Cys Cys Gly Ala Cys  Cys Thr Gly 
    1925                 1930                 1935             


Ala Ala  Thr Cys Cys Thr Cys  Gly Cys Ala Thr Cys  Thr Cys Ala 
    1940                 1945                 1950             


Cys Ala  Cys Ala Cys Thr Thr  Thr Thr Ala Ala Thr  Ala Thr Cys 
    1955                 1960                 1965             


Ala Ala  Cys Gly Ala Thr Ala  Ala Cys Cys Gly Ala  Ala Ala Gly 
    1970                 1975                 1980             


Thr Cys  Ala Thr Gly Cys Ala  Gly Cys Cys Thr Gly  Gly Cys Thr 
    1985                 1990                 1995             


Cys Thr  Gly Cys Thr Gly Ala  Ala Cys Ala Cys Ala  Gly Ala Cys 
    2000                 2005                 2010             


Gly Thr  Gly Thr Ala Cys Cys  Ala Gly Cys Thr Gly  Thr Gly Cys 
    2015                 2020                 2025             


Thr Cys  Thr Ala Cys Thr Cys  Cys Thr Ala Ala Ala  Gly Thr Cys 
    2030                 2035                 2040             


Gly Ala  Thr Gly Ala Ala Cys  Gly Gly Ala Gly Thr  Gly Ala Cys 
    2045                 2050                 2055             


Thr Ala  Thr Gly Cys Ala Ala  Gly Cys Thr Cys Cys  Gly Gly Cys 
    2060                 2065                 2070             


Ala Thr  Cys Gly Ala Gly Gly  Ala Thr Ala Thr Thr  Gly Thr Gly 
    2075                 2080                 2085             


Cys Thr  Gly Gly Ala Cys Ala  Thr Cys Gly Thr Cys  Ala Ala Thr 
    2090                 2095                 2100             


Thr Ala  Cys Gly Ala Thr Gly  Gly Gly Thr Cys Cys  Ala Thr Thr 
    2105                 2110                 2115             


Thr Cys  Thr Ala Cys Thr Ala  Cys Cys Ala Gly Ala  Thr Thr Cys 
    2120                 2125                 2130             


Ala Ala  Gly Ala Ala Cys Ala  Ala Thr Ala Ala Cys  Ala Thr Cys 
    2135                 2140                 2145             


Ala Gly  Cys Thr Thr Thr Gly  Ala Cys Cys Ala Gly  Cys Cys Cys 
    2150                 2155                 2160             


Thr Ala  Cys Gly Cys Cys Gly  Cys Thr Cys Thr Gly  Thr Ala Thr 
    2165                 2170                 2175             


Cys Cys  Ala Thr Cys Cys Gly  Thr Gly Gly Gly Ala  Cys Cys Ala 
    2180                 2185                 2190             


Gly Gly  Ala Ala Thr Cys Thr  Ala Cys Thr Ala Cys  Ala Ala Gly 
    2195                 2200                 2205             


Gly Gly  Ala Ala Ala Ala Ala  Thr Cys Ala Thr Thr  Thr Thr Cys 
    2210                 2215                 2220             


Cys Thr  Gly Gly Gly Cys Thr  Ala Thr Gly Gly Cys  Gly Gly Gly 
    2225                 2230                 2235             


Cys Thr  Gly Gly Ala Ala Cys  Ala Cys Cys Cys Thr  Ala Thr Cys 
    2240                 2245                 2250             


Ala Ala  Cys Gly Ala Gly Ala  Ala Thr Gly Thr Gly  Ala Thr Thr 
    2255                 2260                 2265             


Thr Gly  Cys Ala Ala Cys Ala  Cys Ala Ala Cys Thr  Gly Gly Cys 
    2270                 2275                 2280             


Thr Gly  Thr Cys Cys Ala Gly  Gly Gly Ala Ala Gly  Ala Cys Cys 
    2285                 2290                 2295             


Cys Ala  Gly Ala Gly Gly Gly  Ala Thr Thr Gly Cys  Ala Ala Thr 
    2300                 2305                 2310             


Cys Ala  Gly Gly Cys Cys Ala  Gly Thr Cys Ala Thr  Thr Cys Ala 
    2315                 2320                 2325             


Cys Cys  Cys Thr Gly Gly Thr  Thr Thr Ala Gly Thr  Gly Ala Thr 
    2330                 2335                 2340             


Cys Gly  Gly Ala Gly Ala Ala  Thr Gly Gly Thr Gly  Ala Ala Cys 
    2345                 2350                 2355             


Thr Cys  Ala Ala Thr Cys Ala  Thr Thr Gly Thr Gly  Gly Thr Cys 
    2360                 2365                 2370             


Gly Ala  Cys Ala Ala Ala Gly  Gly Gly Cys Thr Gly  Ala Ala Thr 
    2375                 2380                 2385             


Ala Gly  Cys Ala Thr Cys Cys  Cys Thr Ala Ala Gly  Cys Thr Gly 
    2390                 2395                 2400             


Ala Ala  Ala Gly Thr Cys Thr  Gly Gly Ala Cys Cys  Ala Thr Thr 
    2405                 2410                 2415             


Thr Cys  Ala Ala Thr Gly Cys  Gly Ala Cys Ala Gly  Ala Ala Cys 
    2420                 2425                 2430             


Thr Ala  Cys Thr Gly Gly Gly  Gly Ala Ala Gly Cys  Gly Ala Ala 
    2435                 2440                 2445             


Gly Gly  Cys Cys Gly Gly Cys  Thr Gly Cys Thr Gly  Cys Thr Gly 
    2450                 2455                 2460             


Cys Thr  Gly Gly Gly Cys Ala  Ala Thr Ala Ala Gly  Ala Thr Cys 
    2465                 2470                 2475             


Thr Ala  Cys Ala Thr Cys Thr  Ala Cys Ala Cys Thr  Cys Gly Gly 
    2480                 2485                 2490             


Ala Gly  Cys Ala Cys Cys Thr  Cys Cys Thr Gly Gly  Cys Ala Cys 
    2495                 2500                 2505             


Thr Cys  Cys Ala Ala Ala Cys  Thr Gly Cys Ala Gly  Cys Thr Gly 
    2510                 2515                 2520             


Gly Gly  Gly Ala Thr Cys Ala  Thr Thr Gly Ala Cys  Ala Thr Cys 
    2525                 2530                 2535             


Ala Cys  Cys Gly Ala Thr Thr  Ala Thr Thr Cys Thr  Gly Ala Cys 
    2540                 2545                 2550             


Ala Thr  Cys Cys Gly Gly Ala  Thr Thr Ala Ala Gly  Thr Gly Gly 
    2555                 2560                 2565             


Ala Cys  Ala Thr Gly Gly Cys  Ala Cys Ala Ala Cys  Gly Thr Gly 
    2570                 2575                 2580             


Cys Thr  Gly Thr Cys Ala Ala  Gly Ala Cys Cys Cys  Gly Gly Gly 
    2585                 2590                 2595             


Ala Ala  Thr Ala Ala Cys Gly  Ala Gly Thr Gly Thr  Cys Cys Thr 
    2600                 2605                 2610             


Thr Gly  Gly Gly Gly Ala Cys  Ala Thr Ala Gly Cys  Thr Gly Cys 
    2615                 2620                 2625             


Cys Cys  Ala Gly Ala Thr Gly  Gly Gly Thr Gly Thr  Ala Thr Cys 
    2630                 2635                 2640             


Ala Cys  Cys Gly Gly Ala Gly  Thr Gly Thr Ala Cys  Ala Cys Ala 
    2645                 2650                 2655             


Gly Ala  Cys Gly Cys Thr Thr  Ala Thr Cys Cys Thr  Cys Thr Gly 
    2660                 2665                 2670             


Ala Ala  Cys Cys Cys Ala Ala  Cys Cys Gly Gly Cys  Ala Gly Thr 
    2675                 2680                 2685             


Ala Thr  Cys Gly Thr Gly Thr  Cys Thr Ala Gly Thr  Gly Thr Cys 
    2690                 2695                 2700             


Ala Thr  Thr Cys Thr Gly Gly  Ala Cys Thr Cys Thr  Cys Ala Gly 
    2705                 2710                 2715             


Ala Ala  Ala Ala Gly Thr Ala  Gly Ala Gly Thr Gly  Ala Ala Thr 
    2720                 2725                 2730             


Cys Cys  Cys Gly Thr Cys Ala  Thr Cys Ala Cys Ala  Thr Ala Cys 
    2735                 2740                 2745             


Ala Gly  Cys Ala Cys Cys Gly  Cys Ala Ala Cys Ala  Gly Ala Ala 
    2750                 2755                 2760             


Ala Gly  Ala Gly Thr Gly Ala  Ala Cys Gly Ala Gly  Cys Thr Gly 
    2765                 2770                 2775             


Gly Cys  Cys Ala Thr Thr Cys  Thr Gly Ala Ala Thr  Ala Gly Gly 
    2780                 2785                 2790             


Ala Cys  Thr Cys Thr Gly Ala  Gly Cys Gly Cys Cys  Gly Gly Ala 
    2795                 2800                 2805             


Thr Ala  Thr Ala Cys Cys Ala  Cys Ala Ala Cys Thr  Thr Cys Cys 
    2810                 2815                 2820             


Thr Gly  Cys Ala Thr Cys Ala  Cys Cys Cys Ala Thr  Thr Ala Cys 
    2825                 2830                 2835             


Ala Ala  Cys Ala Ala Gly Gly  Gly Cys Thr Ala Thr  Thr Gly Thr 
    2840                 2845                 2850             


Thr Thr  Cys Cys Ala Cys Ala  Thr Cys Gly Thr Gly  Gly Ala Ala 
    2855                 2860                 2865             


Ala Thr  Thr Ala Ala Cys Cys  Ala Thr Ala Ala Ala  Ala Gly Cys 
    2870                 2875                 2880             


Cys Thr  Gly Ala Ala Thr Ala  Cys Cys Thr Thr Cys  Cys Ala Gly 
    2885                 2890                 2895             


Cys Cys  Cys Ala Thr Gly Cys  Thr Gly Thr Thr Thr  Ala Ala Gly 
    2900                 2905                 2910             


Ala Cys  Ala Gly Ala Gly Ala  Thr Thr Cys Cys Thr  Ala Ala Ala 
    2915                 2920                 2925             


Ala Gly  Thr Thr Gly Thr Thr  Cys Ala Gly Gly Cys  Ala Gly Thr 
    2930                 2935                 2940             


Gly Gly  Gly Thr Cys Ala Gly  Gly Ala Cys Ala Thr  Cys Ala Cys 
    2945                 2950                 2955             


Cys Ala  Thr Cys Ala Thr Cys  Ala Thr Cys Ala Thr  Cys Ala Thr 
    2960                 2965                 2970             


Cys Ala  Cys Cys Ala Thr Cys  Ala Thr Cys Ala Cys  Cys Ala Thr 
    2975                 2980                 2985             


Thr Gly  Ala 
    2990     


<210>  5
<211>  996
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  tFrSc10-HN Construct

<400>  5

Met Glu Leu Pro Ile Leu Lys Ala Asn Ala Ile Thr Thr Ile Leu Ala 
1               5                   10                  15      


Ala Val Thr Phe Cys Phe Ala Ser Ser Gln Asn Ile Thr Glu Glu Phe 
            20                  25                  30          


Tyr Gln Ser Thr Cys Ser Ala Val Ser Lys Gly Tyr Leu Ser Ala Leu 
        35                  40                  45              


Arg Thr Gly Trp Tyr Thr Ser Val Ile Thr Ile Glu Leu Ser Asn Ile 
    50                  55                  60                  


Lys Glu Asn Lys Cys Asn Gly Thr Asp Ala Lys Val Lys Leu Met Lys 
65                  70                  75                  80  


Gln Glu Leu Asp Lys Tyr Lys Asn Ala Val Thr Glu Leu Gln Leu Leu 
                85                  90                  95      


Met Gln Ser Thr Pro Ala Ala Asn Asn Asn Ala Arg Gly Ser Gly Ser 
            100                 105                 110         


Gly Arg Thr Leu Gly Phe Leu Leu Gly Val Gly Ser Ala Ile Ala Ser 
        115                 120                 125             


Gly Ile Ala Val Ser Lys Val Leu His Leu Glu Gly Glu Val Asn Lys 
    130                 135                 140                 


Ile Lys Ser Ala Leu Leu Ser Thr Asn Lys Ala Val Val Ser Leu Ser 
145                 150                 155                 160 


Asn Gly Val Ser Val Leu Thr Ser Lys Val Leu Asp Leu Lys Asn Tyr 
                165                 170                 175     


Ile Asp Lys Gln Leu Leu Pro Ile Val Asn Lys Gln Ser Cys Arg Ile 
            180                 185                 190         


Ser Asn Ile Glu Thr Val Ile Glu Phe Gln Gln Lys Asn Asn Arg Leu 
        195                 200                 205             


Leu Glu Ile Thr Arg Glu Phe Ser Val Asn Val Gly Val Thr Thr Pro 
    210                 215                 220                 


Val Ser Thr Tyr Met Leu Thr Asn Ser Glu Leu Leu Ser Leu Ile Asn 
225                 230                 235                 240 


Asp Met Pro Ile Thr Asn Asp Gln Lys Lys Leu Met Ser Asn Asn Val 
                245                 250                 255     


Gln Ile Val Arg Gln Gln Ser Tyr Ser Ile Met Ser Ile Ile Lys Glu 
            260                 265                 270         


Glu Val Leu Ala Tyr Val Val Gln Leu Pro Leu Tyr Gly Val Ile Asp 
        275                 280                 285             


Thr Pro Cys Trp Lys Leu His Thr Ser Pro Leu Cys Thr Thr Asn Thr 
    290                 295                 300                 


Lys Glu Gly Ser Asn Ile Cys Leu Thr Arg Thr Asp Arg Gly Trp Tyr 
305                 310                 315                 320 


Cys Asp Asn Ala Gly Ser Val Ser Phe Phe Pro Gln Ala Glu Thr Cys 
                325                 330                 335     


Lys Val Gln Ser Asn Arg Val Phe Cys Asp Thr Met Asn Ser Leu Thr 
            340                 345                 350         


Leu Pro Ser Glu Val Asn Leu Cys Asn Val Asp Ile Phe Asn Pro Lys 
        355                 360                 365             


Tyr Asp Cys Lys Ile Met Thr Ser Lys Thr Asp Val Ser Ser Ser Val 
    370                 375                 380                 


Ile Thr Ser Leu Gly Ala Ile Val Ser Cys Tyr Gly Lys Thr Lys Cys 
385                 390                 395                 400 


Thr Ala Ser Asn Lys Asn Arg Gly Ile Ile Lys Thr Phe Ser Asn Gly 
                405                 410                 415     


Cys Asp Tyr Val Ser Asn Lys Gly Val Asp Thr Val Ser Val Gly Asn 
            420                 425                 430         


Thr Leu Tyr Tyr Val Asn Lys Gln Glu Gly Lys Ser Leu Tyr Val Lys 
        435                 440                 445             


Gly Glu Pro Ile Ile Asn Phe Tyr Asp Pro Leu Val Phe Pro Ser Asp 
    450                 455                 460                 


Glu Phe Asp Ala Ser Ile Ser Gln Val Asn Glu Lys Ile Asn Gln Ser 
465                 470                 475                 480 


Leu Ala Phe Ile Arg Lys Ser Asp Glu Leu Leu Gly Ser Thr Asn Asp 
                485                 490                 495     


Leu Ile Gln Ser Gly Val Asn Thr Arg Leu Leu Thr Ile Gln Ser His 
            500                 505                 510         


Val Gln Asn Tyr Ile Pro Ile Ser Leu Thr Gln Gln Met Ser Asp Leu 
        515                 520                 525             


Arg Lys Phe Ile Ser Glu Ile Thr Ile Arg Asn Asp Asn Gln Glu Val 
    530                 535                 540                 


Leu Pro Gln Arg Ile Thr His Asp Val Gly Ile Lys Pro Leu Asn Pro 
545                 550                 555                 560 


Asp Asp Phe Trp Arg Cys Thr Ser Gly Leu Pro Ser Leu Met Lys Thr 
                565                 570                 575     


Pro Lys Ile Arg Leu Met Pro Gly Pro Gly Leu Leu Ala Met Pro Thr 
            580                 585                 590         


Thr Val Asp Gly Cys Val Arg Thr Pro Ser Leu Val Ile Asn Asp Leu 
        595                 600                 605             


Ile Tyr Ala Tyr Thr Ser Asn Leu Ile Thr Arg Gly Cys Gln Asp Ile 
    610                 615                 620                 


Gly Lys Ser Tyr Gln Val Leu Gln Ile Gly Ile Ile Thr Val Asn Ser 
625                 630                 635                 640 


Asp Leu Val Pro Asp Leu Asn Pro Arg Ile Ser His Thr Phe Asn Ile 
                645                 650                 655     


Asn Asp Asn Arg Lys Ser Cys Ser Leu Ala Leu Leu Asn Thr Asp Val 
            660                 665                 670         


Tyr Gln Leu Cys Ser Thr Pro Lys Val Asp Glu Arg Ser Asp Tyr Ala 
        675                 680                 685             


Ser Ser Gly Ile Glu Asp Ile Val Leu Asp Ile Val Asn Tyr Asp Gly 
    690                 695                 700                 


Ser Ile Ser Thr Thr Arg Phe Lys Asn Asn Asn Ile Ser Phe Asp Gln 
705                 710                 715                 720 


Pro Tyr Ala Ala Leu Tyr Pro Ser Val Gly Pro Gly Ile Tyr Tyr Lys 
                725                 730                 735     


Gly Lys Ile Ile Phe Leu Gly Tyr Gly Gly Leu Glu His Pro Ile Asn 
            740                 745                 750         


Glu Asn Val Ile Cys Asn Thr Thr Gly Cys Pro Gly Lys Thr Gln Arg 
        755                 760                 765             


Asp Cys Asn Gln Ala Ser His Ser Pro Trp Phe Ser Asp Arg Arg Met 
    770                 775                 780                 


Val Asn Ser Ile Ile Val Val Asp Lys Gly Leu Asn Ser Ile Pro Lys 
785                 790                 795                 800 


Leu Lys Val Trp Thr Ile Ser Met Arg Gln Asn Tyr Trp Gly Ser Glu 
                805                 810                 815     


Gly Arg Leu Leu Leu Leu Gly Asn Lys Ile Tyr Ile Tyr Thr Arg Ser 
            820                 825                 830         


Thr Ser Trp His Ser Lys Leu Gln Leu Gly Ile Ile Asp Ile Thr Asp 
        835                 840                 845             


Tyr Ser Asp Ile Arg Ile Lys Trp Thr Trp His Asn Val Leu Ser Arg 
    850                 855                 860                 


Pro Gly Asn Asn Glu Cys Pro Trp Gly His Ser Cys Pro Asp Gly Cys 
865                 870                 875                 880 


Ile Thr Gly Val Tyr Thr Asp Ala Tyr Pro Leu Asn Pro Thr Gly Ser 
                885                 890                 895     


Ile Val Ser Ser Val Ile Leu Asp Ser Gln Lys Ser Arg Val Asn Pro 
            900                 905                 910         


Val Ile Thr Tyr Ser Thr Ala Thr Glu Arg Val Asn Glu Leu Ala Ile 
        915                 920                 925             


Leu Asn Arg Thr Leu Ser Ala Gly Tyr Thr Thr Thr Ser Cys Ile Thr 
    930                 935                 940                 


His Tyr Asn Lys Gly Tyr Cys Phe His Ile Val Glu Ile Asn His Lys 
945                 950                 955                 960 


Ser Leu Asn Thr Phe Gln Pro Met Leu Phe Lys Thr Glu Ile Pro Lys 
                965                 970                 975     


Ser Cys Ser Gly Ser Gly Ser Gly His His His His His His His His 
            980                 985                 990         


His His His His 
        995     


<210>  6
<211>  2991
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  tFrSc10-HN Construct

<400>  6

Ala Thr Gly Gly Ala Gly Cys Thr Gly Cys Cys Thr Ala Thr Cys Cys 
1               5                   10                  15      


Thr Gly Ala Ala Gly Gly Cys Cys Ala Ala Cys Gly Cys Cys Ala Thr 
            20                  25                  30          


Cys Ala Cys Cys Ala Cys Ala Ala Thr Thr Cys Thr Gly Gly Cys Cys 
        35                  40                  45              


Gly Cys Cys Gly Thr Gly Ala Cys Cys Thr Thr Cys Thr Gly Thr Thr 
    50                  55                  60                  


Thr Thr Gly Cys Cys Ala Gly Cys Ala Gly Cys Cys Ala Gly Ala Ala 
65                  70                  75                  80  


Cys Ala Thr Cys Ala Cys Cys Gly Ala Gly Gly Ala Gly Thr Thr Cys 
                85                  90                  95      


Thr Ala Cys Cys Ala Gly Ala Gly Cys Ala Cys Cys Thr Gly Thr Ala 
            100                 105                 110         


Gly Cys Gly Cys Cys Gly Thr Gly Ala Gly Cys Ala Ala Gly Gly Gly 
        115                 120                 125             


Cys Thr Ala Thr Cys Thr Gly Ala Gly Cys Gly Cys Cys Cys Thr Gly 
    130                 135                 140                 


Ala Gly Ala Ala Cys Cys Gly Gly Cys Thr Gly Gly Thr Ala Cys Ala 
145                 150                 155                 160 


Cys Cys Ala Gly Cys Gly Thr Gly Ala Thr Cys Ala Cys Cys Ala Thr 
                165                 170                 175     


Cys Gly Ala Gly Cys Thr Gly Ala Gly Cys Ala Ala Cys Ala Thr Cys 
            180                 185                 190         


Ala Ala Gly Gly Ala Gly Ala Ala Cys Ala Ala Gly Thr Gly Cys Ala 
        195                 200                 205             


Ala Cys Gly Gly Cys Ala Cys Cys Gly Ala Cys Gly Cys Cys Ala Ala 
    210                 215                 220                 


Gly Gly Thr Gly Ala Ala Gly Cys Thr Gly Ala Thr Gly Ala Ala Gly 
225                 230                 235                 240 


Cys Ala Gly Gly Ala Gly Cys Thr Gly Gly Ala Cys Ala Ala Gly Thr 
                245                 250                 255     


Ala Cys Ala Ala Gly Ala Ala Cys Gly Cys Cys Gly Thr Gly Ala Cys 
            260                 265                 270         


Cys Gly Ala Ala Cys Thr Gly Cys Ala Gly Cys Thr Gly Cys Thr Gly 
        275                 280                 285             


Ala Thr Gly Cys Ala Gly Thr Cys Thr Ala Cys Cys Cys Cys Thr Gly 
    290                 295                 300                 


Cys Cys Gly Cys Cys Ala Ala Cys Ala Ala Cys Ala Ala Cys Gly Cys 
305                 310                 315                 320 


Cys Ala Gly Ala Gly Gly Cys Ala Gly Cys Gly Gly Cys Ala Gly Cys 
                325                 330                 335     


Gly Gly Cys Ala Gly Ala Ala Cys Cys Cys Thr Gly Gly Gly Cys Thr 
            340                 345                 350         


Thr Thr Cys Thr Gly Cys Thr Gly Gly Gly Ala Gly Thr Gly Gly Gly 
        355                 360                 365             


Cys Thr Cys Thr Gly Cys Cys Ala Thr Cys Gly Cys Cys Thr Cys Thr 
    370                 375                 380                 


Gly Gly Cys Ala Thr Cys Gly Cys Cys Gly Thr Gly Thr Cys Thr Ala 
385                 390                 395                 400 


Ala Gly Gly Thr Gly Cys Thr Gly Cys Ala Cys Cys Thr Gly Gly Ala 
                405                 410                 415     


Gly Gly Gly Ala Gly Ala Gly Gly Thr Gly Ala Ala Cys Ala Ala Gly 
            420                 425                 430         


Ala Thr Cys Ala Ala Gly Ala Gly Cys Gly Cys Cys Cys Thr Gly Cys 
        435                 440                 445             


Thr Gly Ala Gly Cys Ala Cys Cys Ala Ala Thr Ala Ala Gly Gly Cys 
    450                 455                 460                 


Cys Gly Thr Gly Gly Thr Gly Ala Gly Cys Cys Thr Gly Ala Gly Cys 
465                 470                 475                 480 


Ala Ala Thr Gly Gly Cys Gly Thr Gly Ala Gly Cys Gly Thr Gly Cys 
                485                 490                 495     


Thr Gly Ala Cys Ala Ala Gly Cys Ala Ala Gly Gly Thr Gly Cys Thr 
            500                 505                 510         


Gly Gly Ala Cys Cys Thr Cys Ala Ala Gly Ala Ala Cys Thr Ala Cys 
        515                 520                 525             


Ala Thr Cys Gly Ala Cys Ala Ala Gly Cys Ala Gly Cys Thr Gly Cys 
    530                 535                 540                 


Thr Gly Cys Cys Cys Ala Thr Cys Gly Thr Gly Ala Ala Cys Ala Ala 
545                 550                 555                 560 


Gly Cys Ala Gly Ala Gly Cys Thr Gly Cys Cys Gly Gly Ala Thr Cys 
                565                 570                 575     


Ala Gly Cys Ala Ala Cys Ala Thr Cys Gly Ala Gly Ala Cys Cys Gly 
            580                 585                 590         


Thr Gly Ala Thr Cys Gly Ala Gly Thr Thr Cys Cys Ala Gly Cys Ala 
        595                 600                 605             


Gly Ala Ala Gly Ala Ala Cys Ala Ala Cys Cys Gly Gly Cys Thr Gly 
    610                 615                 620                 


Cys Thr Gly Gly Ala Gly Ala Thr Cys Ala Cys Cys Ala Gly Gly Gly 
625                 630                 635                 640 


Ala Gly Thr Thr Cys Ala Gly Cys Gly Thr Gly Ala Ala Thr Gly Thr 
                645                 650                 655     


Gly Gly Gly Cys Gly Thr Gly Ala Cys Cys Ala Cys Cys Cys Cys Thr 
            660                 665                 670         


Gly Thr Gly Ala Gly Cys Ala Cys Cys Thr Ala Cys Ala Thr Gly Cys 
        675                 680                 685             


Thr Gly Ala Cys Cys Ala Ala Cys Ala Gly Cys Gly Ala Gly Cys Thr 
    690                 695                 700                 


Gly Cys Thr Gly Ala Gly Cys Cys Thr Gly Ala Thr Cys Ala Ala Cys 
705                 710                 715                 720 


Gly Ala Cys Ala Thr Gly Cys Cys Cys Ala Thr Cys Ala Cys Cys Ala 
                725                 730                 735     


Ala Cys Gly Ala Cys Cys Ala Gly Ala Ala Gly Ala Ala Gly Cys Thr 
            740                 745                 750         


Gly Ala Thr Gly Thr Cys Cys Ala Ala Cys Ala Ala Cys Gly Thr Gly 
        755                 760                 765             


Cys Ala Gly Ala Thr Cys Gly Thr Gly Cys Gly Gly Cys Ala Gly Cys 
    770                 775                 780                 


Ala Gly Ala Gly Cys Thr Ala Cys Ala Gly Cys Ala Thr Cys Ala Thr 
785                 790                 795                 800 


Gly Thr Cys Cys Ala Thr Cys Ala Thr Cys Ala Ala Gly Gly Ala Gly 
                805                 810                 815     


Gly Ala Gly Gly Thr Gly Cys Thr Gly Gly Cys Thr Thr Ala Cys Gly 
            820                 825                 830         


Thr Gly Gly Thr Gly Cys Ala Gly Cys Thr Gly Cys Cys Thr Cys Thr 
        835                 840                 845             


Gly Thr Ala Cys Gly Gly Cys Gly Thr Gly Ala Thr Cys Gly Ala Cys 
    850                 855                 860                 


Ala Cys Cys Cys Cys Thr Thr Gly Cys Thr Gly Gly Ala Ala Gly Cys 
865                 870                 875                 880 


Thr Gly Cys Ala Cys Ala Cys Cys Ala Gly Cys Cys Cys Thr Cys Thr 
                885                 890                 895     


Gly Thr Gly Cys Ala Cys Cys Ala Cys Cys Ala Ala Thr Ala Cys Cys 
            900                 905                 910         


Ala Ala Gly Gly Ala Gly Gly Gly Cys Ala Gly Cys Ala Ala Cys Ala 
        915                 920                 925             


Thr Cys Thr Gly Cys Cys Thr Gly Ala Cys Cys Ala Gly Gly Ala Cys 
    930                 935                 940                 


Cys Gly Ala Thr Ala Gly Ala Gly Gly Cys Thr Gly Gly Thr Ala Cys 
945                 950                 955                 960 


Thr Gly Cys Gly Ala Cys Ala Ala Thr Gly Cys Cys Gly Gly Cys Ala 
                965                 970                 975     


Gly Cys Gly Thr Gly Ala Gly Cys Thr Thr Cys Thr Thr Thr Cys Cys 
            980                 985                 990         


Ala Cys Ala Gly Gly Cys Cys Gly  Ala Gly Ala Cys Cys  Thr Gly Thr 
        995                 1000                 1005             


Ala Ala  Gly Gly Thr Gly Cys  Ala Gly Ala Gly Cys  Ala Ala Cys 
    1010                 1015                 1020             


Cys Gly  Gly Gly Thr Gly Thr  Thr Cys Thr Gly Cys  Gly Ala Cys 
    1025                 1030                 1035             


Ala Cys  Cys Ala Thr Gly Ala  Ala Cys Ala Gly Cys  Cys Thr Gly 
    1040                 1045                 1050             


Ala Cys  Cys Cys Thr Gly Cys  Cys Thr Thr Cys Thr  Gly Ala Gly 
    1055                 1060                 1065             


Gly Thr  Gly Ala Ala Cys Cys  Thr Gly Thr Gly Cys  Ala Ala Cys 
    1070                 1075                 1080             


Gly Thr  Gly Gly Ala Cys Ala  Thr Cys Thr Thr Cys  Ala Ala Cys 
    1085                 1090                 1095             


Cys Cys  Cys Ala Ala Gly Thr  Ala Cys Gly Ala Cys  Thr Gly Cys 
    1100                 1105                 1110             


Ala Ala  Gly Ala Thr Cys Ala  Thr Gly Ala Cys Cys  Ala Gly Cys 
    1115                 1120                 1125             


Ala Ala  Gly Ala Cys Cys Gly  Ala Cys Gly Thr Gly  Ala Gly Cys 
    1130                 1135                 1140             


Ala Gly  Cys Ala Gly Cys Gly  Thr Gly Ala Thr Thr  Ala Cys Ala 
    1145                 1150                 1155             


Ala Gly  Cys Cys Thr Gly Gly  Gly Cys Gly Cys Cys  Ala Thr Cys 
    1160                 1165                 1170             


Gly Thr  Gly Ala Gly Cys Thr  Gly Thr Thr Ala Cys  Gly Gly Cys 
    1175                 1180                 1185             


Ala Ala  Gly Ala Cys Cys Ala  Ala Gly Thr Gly Cys  Ala Cys Cys 
    1190                 1195                 1200             


Gly Cys  Cys Ala Gly Cys Ala  Ala Cys Ala Ala Gly  Ala Ala Cys 
    1205                 1210                 1215             


Cys Gly  Cys Gly Gly Cys Ala  Thr Cys Ala Thr Cys  Ala Ala Gly 
    1220                 1225                 1230             


Ala Cys  Cys Thr Thr Cys Ala  Gly Cys Ala Ala Cys  Gly Gly Cys 
    1235                 1240                 1245             


Thr Gly  Cys Gly Ala Cys Thr  Ala Cys Gly Thr Gly  Ala Gly Cys 
    1250                 1255                 1260             


Ala Ala  Cys Ala Ala Gly Gly  Gly Cys Gly Thr Gly  Gly Ala Thr 
    1265                 1270                 1275             


Ala Cys  Ala Gly Thr Gly Ala  Gly Cys Gly Thr Gly  Gly Gly Cys 
    1280                 1285                 1290             


Ala Ala  Cys Ala Cys Cys Cys  Thr Gly Thr Ala Cys  Thr Ala Cys 
    1295                 1300                 1305             


Gly Thr  Cys Ala Ala Cys Ala  Ala Gly Cys Ala Gly  Gly Ala Gly 
    1310                 1315                 1320             


Gly Gly  Cys Ala Ala Gly Ala  Gly Cys Cys Thr Gly  Thr Ala Cys 
    1325                 1330                 1335             


Gly Thr  Gly Ala Ala Gly Gly  Gly Cys Gly Ala Gly  Cys Cys Cys 
    1340                 1345                 1350             


Ala Thr  Cys Ala Thr Cys Ala  Ala Cys Thr Thr Cys  Thr Ala Cys 
    1355                 1360                 1365             


Gly Ala  Cys Cys Cys Cys Cys  Thr Gly Gly Thr Gly  Thr Thr Cys 
    1370                 1375                 1380             


Cys Cys  Thr Ala Gly Cys Gly  Ala Cys Gly Ala Gly  Thr Thr Cys 
    1385                 1390                 1395             


Gly Ala  Thr Gly Cys Cys Ala  Gly Cys Ala Thr Cys  Ala Gly Cys 
    1400                 1405                 1410             


Cys Ala  Gly Gly Thr Gly Ala  Ala Cys Gly Ala Gly  Ala Ala Gly 
    1415                 1420                 1425             


Ala Thr  Cys Ala Ala Cys Cys  Ala Gly Ala Gly Cys  Cys Thr Gly 
    1430                 1435                 1440             


Gly Cys  Cys Thr Thr Cys Ala  Thr Cys Ala Gly Gly  Ala Ala Gly 
    1445                 1450                 1455             


Ala Gly  Cys Gly Ala Cys Gly  Ala Gly Cys Thr Gly  Cys Thr Gly 
    1460                 1465                 1470             


Gly Gly  Ala Thr Cys Cys Ala  Cys Thr Ala Ala Cys  Gly Ala Cys 
    1475                 1480                 1485             


Cys Thr  Gly Ala Thr Cys Cys  Ala Gly Thr Cys Thr  Gly Gly Cys 
    1490                 1495                 1500             


Gly Thr  Gly Ala Ala Cys Ala  Cys Ala Ala Gly Gly  Cys Thr Gly 
    1505                 1510                 1515             


Cys Thr  Gly Ala Cys Thr Ala  Thr Thr Cys Ala Gly  Ala Gly Cys 
    1520                 1525                 1530             


Cys Ala  Cys Gly Thr Cys Cys  Ala Gly Ala Ala Thr  Thr Ala Cys 
    1535                 1540                 1545             


Ala Thr  Cys Cys Cys Ala Ala  Thr Thr Thr Cys Cys  Cys Thr Gly 
    1550                 1555                 1560             


Ala Cys  Ala Cys Ala Gly Cys  Ala Gly Ala Thr Gly  Thr Cys Thr 
    1565                 1570                 1575             


Gly Ala  Cys Cys Thr Gly Ala  Gly Gly Ala Ala Gly  Thr Thr Cys 
    1580                 1585                 1590             


Ala Thr  Cys Thr Cys Cys Gly  Ala Ala Ala Thr Cys  Ala Cys Thr 
    1595                 1600                 1605             


Ala Thr  Thr Cys Gly Cys Ala  Ala Thr Gly Ala Thr  Ala Ala Cys 
    1610                 1615                 1620             


Cys Ala  Gly Gly Ala Gly Gly  Thr Gly Cys Thr Gly  Cys Cys Cys 
    1625                 1630                 1635             


Cys Ala  Gly Cys Gly Cys Ala  Thr Cys Ala Cys Cys  Cys Ala Thr 
    1640                 1645                 1650             


Gly Ala  Cys Gly Thr Gly Gly  Gly Cys Ala Thr Cys  Ala Ala Gly 
    1655                 1660                 1665             


Cys Cys  Ala Cys Thr Gly Ala  Ala Cys Cys Cys Cys  Gly Ala Cys 
    1670                 1675                 1680             


Gly Ala  Thr Thr Thr Thr Thr  Gly Gly Ala Gly Gly  Thr Gly Cys 
    1685                 1690                 1695             


Ala Cys  Thr Thr Cys Ala Gly  Gly Ala Cys Thr Gly  Cys Cys Thr 
    1700                 1705                 1710             


Ala Gly  Cys Cys Thr Gly Ala  Thr Gly Ala Ala Gly  Ala Cys Cys 
    1715                 1720                 1725             


Cys Cys  Ala Ala Ala Ala Ala  Thr Cys Cys Gly Ala  Cys Thr Gly 
    1730                 1735                 1740             


Ala Thr  Gly Cys Cys Ala Gly  Gly Ala Cys Cys Thr  Gly Gly Ala 
    1745                 1750                 1755             


Cys Thr  Gly Cys Thr Gly Gly  Cys Ala Ala Thr Gly  Cys Cys Ala 
    1760                 1765                 1770             


Ala Cys  Cys Ala Cys Ala Gly  Thr Gly Gly Ala Thr  Gly Gly Ala 
    1775                 1780                 1785             


Thr Gly  Cys Gly Thr Cys Cys  Gly Ala Ala Cys Cys  Cys Cys Cys 
    1790                 1795                 1800             


Thr Cys  Thr Cys Thr Gly Gly  Thr Cys Ala Thr Cys  Ala Ala Cys 
    1805                 1810                 1815             


Gly Ala  Cys Cys Thr Gly Ala  Thr Cys Thr Ala Cys  Gly Cys Cys 
    1820                 1825                 1830             


Thr Ala  Thr Ala Cys Thr Ala  Gly Thr Ala Ala Thr  Cys Thr Gly 
    1835                 1840                 1845             


Ala Thr  Cys Ala Cys Cys Cys  Gly Cys Gly Gly Cys  Thr Gly Thr 
    1850                 1855                 1860             


Cys Ala  Gly Gly Ala Cys Ala  Thr Thr Gly Gly Gly  Ala Ala Gly 
    1865                 1870                 1875             


Thr Cys  Cys Thr Ala Cys Cys  Ala Gly Gly Thr Gly  Cys Thr Gly 
    1880                 1885                 1890             


Cys Ala  Gly Ala Thr Cys Gly  Gly Cys Ala Thr Cys  Ala Thr Thr 
    1895                 1900                 1905             


Ala Cys  Ala Gly Thr Gly Ala  Ala Cys Ala Gly Thr  Gly Ala Thr 
    1910                 1915                 1920             


Cys Thr  Gly Gly Thr Cys Cys  Cys Cys Gly Ala Cys  Cys Thr Gly 
    1925                 1930                 1935             


Ala Ala  Thr Cys Cys Thr Cys  Gly Cys Ala Thr Cys  Thr Cys Ala 
    1940                 1945                 1950             


Cys Ala  Cys Ala Cys Thr Thr  Thr Thr Ala Ala Thr  Ala Thr Cys 
    1955                 1960                 1965             


Ala Ala  Cys Gly Ala Thr Ala  Ala Cys Cys Gly Ala  Ala Ala Gly 
    1970                 1975                 1980             


Thr Cys  Ala Thr Gly Cys Ala  Gly Cys Cys Thr Gly  Gly Cys Thr 
    1985                 1990                 1995             


Cys Thr  Gly Cys Thr Gly Ala  Ala Cys Ala Cys Ala  Gly Ala Cys 
    2000                 2005                 2010             


Gly Thr  Gly Thr Ala Cys Cys  Ala Gly Cys Thr Gly  Thr Gly Cys 
    2015                 2020                 2025             


Thr Cys  Thr Ala Cys Thr Cys  Cys Thr Ala Ala Ala  Gly Thr Cys 
    2030                 2035                 2040             


Gly Ala  Thr Gly Ala Ala Cys  Gly Gly Ala Gly Thr  Gly Ala Cys 
    2045                 2050                 2055             


Thr Ala  Thr Gly Cys Ala Ala  Gly Cys Thr Cys Cys  Gly Gly Cys 
    2060                 2065                 2070             


Ala Thr  Cys Gly Ala Gly Gly  Ala Thr Ala Thr Thr  Gly Thr Gly 
    2075                 2080                 2085             


Cys Thr  Gly Gly Ala Cys Ala  Thr Cys Gly Thr Cys  Ala Ala Thr 
    2090                 2095                 2100             


Thr Ala  Cys Gly Ala Thr Gly  Gly Gly Thr Cys Cys  Ala Thr Thr 
    2105                 2110                 2115             


Thr Cys  Thr Ala Cys Thr Ala  Cys Cys Ala Gly Ala  Thr Thr Cys 
    2120                 2125                 2130             


Ala Ala  Gly Ala Ala Cys Ala  Ala Thr Ala Ala Cys  Ala Thr Cys 
    2135                 2140                 2145             


Ala Gly  Cys Thr Thr Thr Gly  Ala Cys Cys Ala Gly  Cys Cys Cys 
    2150                 2155                 2160             


Thr Ala  Cys Gly Cys Cys Gly  Cys Thr Cys Thr Gly  Thr Ala Thr 
    2165                 2170                 2175             


Cys Cys  Ala Thr Cys Cys Gly  Thr Gly Gly Gly Ala  Cys Cys Ala 
    2180                 2185                 2190             


Gly Gly  Ala Ala Thr Cys Thr  Ala Cys Thr Ala Cys  Ala Ala Gly 
    2195                 2200                 2205             


Gly Gly  Ala Ala Ala Ala Ala  Thr Cys Ala Thr Thr  Thr Thr Cys 
    2210                 2215                 2220             


Cys Thr  Gly Gly Gly Cys Thr  Ala Thr Gly Gly Cys  Gly Gly Gly 
    2225                 2230                 2235             


Cys Thr  Gly Gly Ala Ala Cys  Ala Cys Cys Cys Thr  Ala Thr Cys 
    2240                 2245                 2250             


Ala Ala  Cys Gly Ala Gly Ala  Ala Thr Gly Thr Gly  Ala Thr Thr 
    2255                 2260                 2265             


Thr Gly  Cys Ala Ala Cys Ala  Cys Ala Ala Cys Thr  Gly Gly Cys 
    2270                 2275                 2280             


Thr Gly  Thr Cys Cys Ala Gly  Gly Gly Ala Ala Gly  Ala Cys Cys 
    2285                 2290                 2295             


Cys Ala  Gly Ala Gly Gly Gly  Ala Thr Thr Gly Cys  Ala Ala Thr 
    2300                 2305                 2310             


Cys Ala  Gly Gly Cys Cys Ala  Gly Thr Cys Ala Thr  Thr Cys Ala 
    2315                 2320                 2325             


Cys Cys  Cys Thr Gly Gly Thr  Thr Thr Ala Gly Thr  Gly Ala Thr 
    2330                 2335                 2340             


Cys Gly  Gly Ala Gly Ala Ala  Thr Gly Gly Thr Gly  Ala Ala Cys 
    2345                 2350                 2355             


Thr Cys  Ala Ala Thr Cys Ala  Thr Thr Gly Thr Gly  Gly Thr Cys 
    2360                 2365                 2370             


Gly Ala  Cys Ala Ala Ala Gly  Gly Gly Cys Thr Gly  Ala Ala Thr 
    2375                 2380                 2385             


Ala Gly  Cys Ala Thr Cys Cys  Cys Thr Ala Ala Gly  Cys Thr Gly 
    2390                 2395                 2400             


Ala Ala  Ala Gly Thr Cys Thr  Gly Gly Ala Cys Cys  Ala Thr Thr 
    2405                 2410                 2415             


Thr Cys  Ala Ala Thr Gly Cys  Gly Ala Cys Ala Gly  Ala Ala Cys 
    2420                 2425                 2430             


Thr Ala  Cys Thr Gly Gly Gly  Gly Ala Ala Gly Cys  Gly Ala Ala 
    2435                 2440                 2445             


Gly Gly  Cys Cys Gly Gly Cys  Thr Gly Cys Thr Gly  Cys Thr Gly 
    2450                 2455                 2460             


Cys Thr  Gly Gly Gly Cys Ala  Ala Thr Ala Ala Gly  Ala Thr Cys 
    2465                 2470                 2475             


Thr Ala  Cys Ala Thr Cys Thr  Ala Cys Ala Cys Thr  Cys Gly Gly 
    2480                 2485                 2490             


Ala Gly  Cys Ala Cys Cys Thr  Cys Cys Thr Gly Gly  Cys Ala Cys 
    2495                 2500                 2505             


Thr Cys  Cys Ala Ala Ala Cys  Thr Gly Cys Ala Gly  Cys Thr Gly 
    2510                 2515                 2520             


Gly Gly  Gly Ala Thr Cys Ala  Thr Thr Gly Ala Cys  Ala Thr Cys 
    2525                 2530                 2535             


Ala Cys  Cys Gly Ala Thr Thr  Ala Thr Thr Cys Thr  Gly Ala Cys 
    2540                 2545                 2550             


Ala Thr  Cys Cys Gly Gly Ala  Thr Thr Ala Ala Gly  Thr Gly Gly 
    2555                 2560                 2565             


Ala Cys  Ala Thr Gly Gly Cys  Ala Cys Ala Ala Cys  Gly Thr Gly 
    2570                 2575                 2580             


Cys Thr  Gly Thr Cys Ala Ala  Gly Ala Cys Cys Cys  Gly Gly Gly 
    2585                 2590                 2595             


Ala Ala  Thr Ala Ala Cys Gly  Ala Gly Thr Gly Thr  Cys Cys Thr 
    2600                 2605                 2610             


Thr Gly  Gly Gly Gly Ala Cys  Ala Thr Ala Gly Cys  Thr Gly Cys 
    2615                 2620                 2625             


Cys Cys  Ala Gly Ala Thr Gly  Gly Gly Thr Gly Thr  Ala Thr Cys 
    2630                 2635                 2640             


Ala Cys  Cys Gly Gly Ala Gly  Thr Gly Thr Ala Cys  Ala Cys Ala 
    2645                 2650                 2655             


Gly Ala  Cys Gly Cys Thr Thr  Ala Thr Cys Cys Thr  Cys Thr Gly 
    2660                 2665                 2670             


Ala Ala  Cys Cys Cys Ala Ala  Cys Cys Gly Gly Cys  Ala Gly Thr 
    2675                 2680                 2685             


Ala Thr  Cys Gly Thr Gly Thr  Cys Thr Ala Gly Thr  Gly Thr Cys 
    2690                 2695                 2700             


Ala Thr  Thr Cys Thr Gly Gly  Ala Cys Thr Cys Thr  Cys Ala Gly 
    2705                 2710                 2715             


Ala Ala  Ala Ala Gly Thr Ala  Gly Ala Gly Thr Gly  Ala Ala Thr 
    2720                 2725                 2730             


Cys Cys  Cys Gly Thr Cys Ala  Thr Cys Ala Cys Ala  Thr Ala Cys 
    2735                 2740                 2745             


Ala Gly  Cys Ala Cys Cys Gly  Cys Ala Ala Cys Ala  Gly Ala Ala 
    2750                 2755                 2760             


Ala Gly  Ala Gly Thr Gly Ala  Ala Cys Gly Ala Gly  Cys Thr Gly 
    2765                 2770                 2775             


Gly Cys  Cys Ala Thr Thr Cys  Thr Gly Ala Ala Thr  Ala Gly Gly 
    2780                 2785                 2790             


Ala Cys  Thr Cys Thr Gly Ala  Gly Cys Gly Cys Cys  Gly Gly Ala 
    2795                 2800                 2805             


Thr Ala  Thr Ala Cys Cys Ala  Cys Ala Ala Cys Thr  Thr Cys Cys 
    2810                 2815                 2820             


Thr Gly  Cys Ala Thr Cys Ala  Cys Cys Cys Ala Thr  Thr Ala Cys 
    2825                 2830                 2835             


Ala Ala  Cys Ala Ala Gly Gly  Gly Cys Thr Ala Thr  Thr Gly Thr 
    2840                 2845                 2850             


Thr Thr  Cys Cys Ala Cys Ala  Thr Cys Gly Thr Gly  Gly Ala Ala 
    2855                 2860                 2865             


Ala Thr  Thr Ala Ala Cys Cys  Ala Thr Ala Ala Ala  Ala Gly Cys 
    2870                 2875                 2880             


Cys Thr  Gly Ala Ala Thr Ala  Cys Cys Thr Thr Cys  Cys Ala Gly 
    2885                 2890                 2895             


Cys Cys  Cys Ala Thr Gly Cys  Thr Gly Thr Thr Thr  Ala Ala Gly 
    2900                 2905                 2910             


Ala Cys  Ala Gly Ala Gly Ala  Thr Thr Cys Cys Thr  Ala Ala Ala 
    2915                 2920                 2925             


Ala Gly  Thr Thr Gly Thr Thr  Cys Ala Gly Gly Cys  Ala Gly Thr 
    2930                 2935                 2940             


Gly Gly  Gly Thr Cys Ala Gly  Gly Ala Cys Ala Thr  Cys Ala Cys 
    2945                 2950                 2955             


Cys Ala  Thr Cys Ala Thr Cys  Ala Thr Cys Ala Thr  Cys Ala Thr 
    2960                 2965                 2970             


Cys Ala  Cys Cys Ala Thr Cys  Ala Thr Cys Ala Cys  Cys Ala Thr 
    2975                 2980                 2985             


Thr Gly  Ala 
    2990     


