                         SEQUENCE LISTING

<110>  WUGEN, INC.
 
<120>  IMPROVED CHIMERIC ANTIGEN RECEPTORS AND USES THEREOF

<130>  WGN0021-401-PC

<140>  PCT/US 22/071692
<141>  2022-04-13

<150>  63/174,321
<151>  2021-04-13

<160>  76    

<170>  PatentIn version 3.5

<210>  1
<211>  21
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  CD8? signal/leader peptide (variant 1)

<400>  1

Met Ala Leu Pro Val Thr Ala Leu Leu Leu Pro Leu Ala Leu Leu Leu 
1               5                   10                  15      


His Ala Ala Arg Pro 
            20      


<210>  2
<211>  19
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  CD8? signal/leader peptide (variant 2)

<400>  2

Met Ala Leu Pro Val Thr Ala Leu Leu Leu Pro Leu Ala Leu Leu Leu 
1               5                   10                  15      


His Ala Ala 
            


<210>  3
<211>  11
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  CD8? signal/leader peptide (variant 3)

<400>  3

Met Ala Leu Pro Val Thr Ala Leu Leu Leu Pro 
1               5                   10      


<210>  4
<211>  12
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  CD8? signal/leader peptide (variant 4)

<400>  4

Pro Val Thr Ala Leu Leu Leu Pro Leu Ala Leu Leu 
1               5                   10          


<210>  5
<211>  14
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  CD8? signal/leader peptide (variant 5)

<400>  5

Leu Leu Leu Pro Leu Ala Leu Leu Leu His Ala Ala Arg Pro 
1               5                   10                  


<210>  6
<211>  45
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  CD8  hinge

<400>  6

Thr Thr Thr Pro Ala Pro Arg Pro Pro Thr Pro Ala Pro Thr Ile Ala 
1               5                   10                  15      


Ser Gln Pro Leu Ser Leu Arg Pro Glu Ala Cys Arg Pro Ala Ala Gly 
            20                  25                  30          


Gly Ala Val His Thr Arg Gly Leu Asp Phe Ala Cys Asp 
        35                  40                  45  


<210>  7
<211>  27
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  CD28 Transmembrane (Tm) domain

<400>  7

Phe Trp Val Leu Val Val Val Gly Gly Val Leu Ala Cys Tyr Ser Leu 
1               5                   10                  15      


Leu Val Thr Val Ala Phe Ile Ile Phe Trp Val 
            20                  25          


<210>  8
<211>  235
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Surface glycoprotein CD8 alpha chain isoform 1 precursor 
       (NP_001139345.1)

<400>  8

Met Ala Leu Pro Val Thr Ala Leu Leu Leu Pro Leu Ala Leu Leu Leu 
1               5                   10                  15      


His Ala Ala Arg Pro Ser Gln Phe Arg Val Ser Pro Leu Asp Arg Thr 
            20                  25                  30          


Trp Asn Leu Gly Glu Thr Val Glu Leu Lys Cys Gln Val Leu Leu Ser 
        35                  40                  45              


Asn Pro Thr Ser Gly Cys Ser Trp Leu Phe Gln Pro Arg Gly Ala Ala 
    50                  55                  60                  


Ala Ser Pro Thr Phe Leu Leu Tyr Leu Ser Gln Asn Lys Pro Lys Ala 
65                  70                  75                  80  


Ala Glu Gly Leu Asp Thr Gln Arg Phe Ser Gly Lys Arg Leu Gly Asp 
                85                  90                  95      


Thr Phe Val Leu Thr Leu Ser Asp Phe Arg Arg Glu Asn Glu Gly Tyr 
            100                 105                 110         


Tyr Phe Cys Ser Ala Leu Ser Asn Ser Ile Met Tyr Phe Ser His Phe 
        115                 120                 125             


Val Pro Val Phe Leu Pro Ala Lys Pro Thr Thr Thr Pro Ala Pro Arg 
    130                 135                 140                 


Pro Pro Thr Pro Ala Pro Thr Ile Ala Ser Gln Pro Leu Ser Leu Arg 
145                 150                 155                 160 


Pro Glu Ala Cys Arg Pro Ala Ala Gly Gly Ala Val His Thr Arg Gly 
                165                 170                 175     


Leu Asp Phe Ala Cys Asp Ile Tyr Ile Trp Ala Pro Leu Ala Gly Thr 
            180                 185                 190         


Cys Gly Val Leu Leu Leu Ser Leu Val Ile Thr Leu Tyr Cys Asn His 
        195                 200                 205             


Arg Asn Arg Arg Arg Val Cys Lys Cys Pro Arg Pro Val Val Lys Ser 
    210                 215                 220                 


Gly Asp Lys Pro Ser Leu Ser Ala Arg Tyr Val 
225                 230                 235 


<210>  9
<211>  42
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  4-1BB costimulatory domain

<400>  9

Lys Arg Gly Arg Lys Lys Leu Leu Tyr Ile Phe Lys Gln Pro Phe Met 
1               5                   10                  15      


Arg Pro Val Gln Thr Thr Gln Glu Glu Asp Gly Cys Ser Cys Arg Phe 
            20                  25                  30          


Pro Glu Glu Glu Glu Gly Gly Cys Glu Leu 
        35                  40          


<210>  10
<211>  41
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  CD28 costimulatory domain

<400>  10

Arg Ser Lys Arg Ser Arg Leu Leu His Ser Asp Tyr Met Asn Met Thr 
1               5                   10                  15      


Pro Arg Arg Pro Gly Pro Thr Arg Lys His Tyr Gln Pro Tyr Ala Pro 
            20                  25                  30          


Pro Arg Asp Phe Ala Ala Tyr Arg Ser 
        35                  40      


<210>  11
<211>  116
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  CD2 costimulatory domain

<400>  11

Lys Arg Lys Lys Gln Arg Ser Arg Arg Asn Asp Glu Glu Leu Glu Thr 
1               5                   10                  15      


Arg Ala His Arg Val Ala Thr Glu Glu Arg Gly Arg Lys Pro His Gln 
            20                  25                  30          


Ile Pro Ala Ser Thr Pro Gln Asn Pro Ala Thr Ser Gln His Pro Pro 
        35                  40                  45              


Pro Pro Pro Gly His Arg Ser Gln Ala Pro Ser His Arg Pro Pro Pro 
    50                  55                  60                  


Pro Gly His Arg Val Gln His Gln Pro Gln Lys Arg Pro Pro Ala Pro 
65                  70                  75                  80  


Ser Gly Thr Gln Val His Gln Gln Lys Gly Pro Pro Leu Pro Arg Pro 
                85                  90                  95      


Arg Val Gln Pro Lys Pro Pro His Gly Ala Ala Glu Asn Ser Leu Ser 
            100                 105                 110         


Pro Ser Ser Asn 
        115     


<210>  12
<211>  40
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  CD4 costimulatory domain

<400>  12

Cys Val Arg Cys Arg His Arg Arg Arg Gln Ala Glu Arg Met Ser Gln 
1               5                   10                  15      


Ile Lys Arg Leu Leu Ser Glu Lys Lys Thr Cys Gln Cys Pro His Arg 
            20                  25                  30          


Phe Gln Lys Thr Cys Ser Pro Ile 
        35                  40  


<210>  13
<211>  32
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  CD8a costimulatory domain

<400>  13

Leu Tyr Cys Asn His Arg Asn Arg Arg Arg Val Cys Lys Cys Pro Arg 
1               5                   10                  15      


Pro Val Val Lys Ser Gly Asp Lys Pro Ser Leu Ser Ala Arg Tyr Val 
            20                  25                  30          


<210>  14
<211>  19
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  CD8b costimulatory domain

<400>  14

His Leu Cys Cys Arg Arg Arg Arg Ala Arg Leu Arg Phe Met Lys Gln 
1               5                   10                  15      


Phe Tyr Lys 
            


<210>  15
<211>  235
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  LAT costimulatory domain

<400>  15

His Cys His Arg Leu Pro Gly Ser Tyr Asp Ser Thr Ser Ser Asp Ser 
1               5                   10                  15      


Leu Tyr Pro Arg Gly Ile Gln Phe Lys Arg Pro His Thr Val Ala Pro 
            20                  25                  30          


Trp Pro Pro Ala Tyr Pro Pro Val Thr Ser Tyr Pro Pro Leu Ser Gln 
        35                  40                  45              


Pro Asp Leu Leu Pro Ile Pro Arg Ser Pro Gln Pro Leu Gly Gly Ser 
    50                  55                  60                  


His Arg Thr Pro Ser Ser Arg Arg Asp Ser Asp Gly Ala Asn Ser Val 
65                  70                  75                  80  


Ala Ser Tyr Glu Asn Glu Gly Ala Ser Gly Ile Arg Gly Ala Gln Ala 
                85                  90                  95      


Gly Trp Gly Val Trp Gly Pro Ser Trp Thr Arg Leu Thr Pro Val Ser 
            100                 105                 110         


Leu Pro Pro Glu Pro Ala Cys Glu Asp Ala Asp Glu Asp Glu Asp Asp 
        115                 120                 125             


Tyr His Asn Pro Gly Tyr Leu Val Val Leu Pro Asp Ser Thr Pro Ala 
    130                 135                 140                 


Thr Ser Thr Ala Ala Pro Ser Ala Pro Ala Leu Ser Thr Pro Gly Ile 
145                 150                 155                 160 


Arg Asp Ser Ala Phe Ser Met Glu Ser Ile Asp Asp Tyr Val Asn Val 
                165                 170                 175     


Pro Glu Ser Gly Glu Ser Ala Glu Ala Ser Leu Asp Gly Ser Arg Glu 
            180                 185                 190         


Tyr Val Asn Val Ser Gln Glu Leu His Pro Gly Ala Ala Lys Thr Glu 
        195                 200                 205             


Pro Ala Ala Leu Ser Ser Gln Glu Ala Glu Glu Val Glu Glu Glu Gly 
    210                 215                 220                 


Ala Pro Asp Tyr Glu Asn Leu Gln Glu Leu Asn 
225                 230                 235 


<210>  16
<211>  112
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  CD3 zeta

<400>  16

Arg Val Lys Phe Ser Arg Ser Ala Asp Ala Pro Ala Tyr Lys Gln Gly 
1               5                   10                  15      


Gln Asn Gln Leu Tyr Asn Glu Leu Asn Leu Gly Arg Arg Glu Glu Tyr 
            20                  25                  30          


Asp Val Leu Asp Lys Arg Arg Gly Arg Asp Pro Glu Met Gly Gly Lys 
        35                  40                  45              


Pro Arg Arg Lys Asn Pro Gln Glu Gly Leu Tyr Asn Glu Leu Gln Lys 
    50                  55                  60                  


Asp Lys Met Ala Glu Ala Tyr Ser Glu Ile Gly Met Lys Gly Glu Arg 
65                  70                  75                  80  


Arg Arg Gly Lys Gly His Asp Gly Leu Tyr Gln Gly Leu Ser Thr Ala 
                85                  90                  95      


Thr Lys Asp Thr Tyr Asp Ala Leu His Met Gln Ala Leu Pro Pro Arg 
            100                 105                 110         


<210>  17
<211>  22
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  P2A peptide

<400>  17

Gly Ser Gly Ala Thr Asn Phe Ser Leu Leu Lys Gln Ala Gly Asp Val 
1               5                   10                  15      


Glu Glu Asn Pro Gly Pro 
            20          


<210>  18
<211>  20
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  (GGGGS)4 linker

<400>  18

Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser Gly 
1               5                   10                  15      


Gly Gly Gly Ser 
            20  


<210>  19
<211>  15
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  (GGGGS)3 linker

<400>  19

Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser 
1               5                   10                  15  


<210>  20
<211>  10
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  (GGGGS)2 linker

<400>  20

Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser 
1               5                   10  


<210>  21
<211>  5
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  (GGGGS)1 linker

<400>  21

Gly Gly Gly Gly Ser 
1               5   


<210>  22
<211>  308
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  hCD34

<400>  22

Met Pro Arg Gly Trp Thr Ala Leu Cys Leu Leu Ser Leu Leu Pro Ser 
1               5                   10                  15      


Gly Phe Met Ser Leu Asp Asn Asn Gly Thr Ala Thr Pro Glu Leu Pro 
            20                  25                  30          


Thr Gln Gly Thr Phe Ser Asn Val Ser Thr Asn Val Ser Tyr Gln Glu 
        35                  40                  45              


Thr Thr Thr Pro Ser Thr Leu Gly Ser Thr Ser Leu His Pro Val Ser 
    50                  55                  60                  


Gln His Gly Asn Glu Ala Thr Thr Asn Ile Thr Glu Thr Thr Val Lys 
65                  70                  75                  80  


Phe Thr Ser Thr Ser Val Ile Thr Ser Val Tyr Gly Asn Thr Asn Ser 
                85                  90                  95      


Ser Val Gln Ser Gln Thr Ser Val Ile Ser Thr Val Phe Thr Thr Pro 
            100                 105                 110         


Ala Asn Val Ser Thr Pro Glu Thr Thr Leu Lys Pro Ser Leu Ser Pro 
        115                 120                 125             


Gly Asn Val Ser Asp Leu Ser Thr Thr Ser Thr Ser Leu Ala Thr Ser 
    130                 135                 140                 


Pro Thr Lys Pro Tyr Thr Ser Ser Ser Pro Ile Leu Ser Asp Ile Lys 
145                 150                 155                 160 


Ala Glu Ile Lys Cys Ser Gly Ile Arg Glu Val Lys Leu Thr Gln Gly 
                165                 170                 175     


Ile Cys Leu Glu Gln Asn Lys Thr Ser Ser Cys Ala Glu Phe Lys Lys 
            180                 185                 190         


Asp Arg Gly Glu Gly Leu Ala Arg Val Leu Cys Gly Glu Glu Gln Ala 
        195                 200                 205             


Asp Ala Asp Ala Gly Ala Gln Val Cys Ser Leu Leu Leu Ala Gln Ser 
    210                 215                 220                 


Glu Val Arg Pro Gln Cys Leu Leu Leu Val Leu Ala Asn Arg Thr Glu 
225                 230                 235                 240 


Ile Ser Ser Lys Leu Gln Leu Met Lys Lys His Gln Ser Asp Leu Lys 
                245                 250                 255     


Lys Leu Gly Ile Leu Asp Phe Thr Glu Gln Asp Val Ala Ser His Gln 
            260                 265                 270         


Ser Tyr Ser Gln Lys Thr Leu Ile Ala Leu Val Thr Ser Gly Ala Leu 
        275                 280                 285             


Leu Ala Val Leu Gly Ile Thr Gly Tyr Phe Leu Met Asn Arg Arg Ser 
    290                 295                 300                 


Trp Ser Pro Ile 
305             


<210>  23
<211>  313
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  TrhCD34

<400>  23

Val Gly Pro Phe Glu Ala Met Pro Arg Gly Trp Thr Ala Leu Cys Leu 
1               5                   10                  15      


Leu Ser Leu Leu Pro Ser Gly Phe Met Ser Leu Asp Asn Asn Gly Thr 
            20                  25                  30          


Ala Thr Pro Glu Leu Pro Thr Gln Gly Thr Phe Ser Asn Val Ser Thr 
        35                  40                  45              


Asn Val Ser Tyr Gln Glu Thr Thr Thr Pro Ser Thr Leu Gly Ser Thr 
    50                  55                  60                  


Ser Leu His Pro Val Ser Gln His Gly Asn Glu Ala Thr Thr Asn Ile 
65                  70                  75                  80  


Thr Glu Thr Thr Val Lys Phe Thr Ser Thr Ser Val Ile Thr Ser Val 
                85                  90                  95      


Tyr Gly Asn Thr Asn Ser Ser Val Gln Ser Gln Thr Ser Val Ile Ser 
            100                 105                 110         


Thr Val Phe Thr Thr Pro Ala Asn Val Ser Thr Pro Glu Thr Thr Leu 
        115                 120                 125             


Lys Pro Ser Leu Ser Pro Gly Asn Val Ser Asp Leu Ser Thr Thr Ser 
    130                 135                 140                 


Thr Ser Leu Ala Thr Ser Pro Thr Lys Pro Tyr Thr Ser Ser Ser Pro 
145                 150                 155                 160 


Ile Leu Ser Asp Ile Lys Ala Glu Ile Lys Cys Ser Gly Ile Arg Glu 
                165                 170                 175     


Val Lys Leu Thr Gln Gly Ile Cys Leu Glu Gln Asn Lys Thr Ser Ser 
            180                 185                 190         


Cys Ala Glu Phe Lys Lys Asp Arg Gly Glu Gly Leu Ala Arg Val Leu 
        195                 200                 205             


Cys Gly Glu Glu Gln Ala Asp Ala Asp Ala Gly Ala Gln Val Cys Ser 
    210                 215                 220                 


Leu Leu Leu Ala Gln Ser Glu Val Arg Pro Gln Cys Leu Leu Leu Val 
225                 230                 235                 240 


Leu Ala Asn Arg Thr Glu Ile Ser Ser Lys Leu Gln Leu Met Lys Lys 
                245                 250                 255     


His Gln Ser Asp Leu Lys Lys Leu Gly Ile Leu Asp Phe Thr Glu Gln 
            260                 265                 270         


Asp Val Ala Ser His Gln Ser Tyr Ser Gln Lys Thr Leu Ile Ala Leu 
        275                 280                 285             


Val Thr Ser Gly Ala Leu Leu Ala Val Leu Gly Ile Thr Gly Tyr Phe 
    290                 295                 300                 


Leu Met Asn Arg Arg Ser Trp Ser Pro 
305                 310             


<210>  24
<211>  330
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  P2A-hCD34

<400>  24

Gly Ser Gly Ala Thr Asn Phe Ser Leu Leu Lys Gln Ala Gly Asp Val 
1               5                   10                  15      


Glu Glu Asn Pro Gly Pro Met Pro Arg Gly Trp Thr Ala Leu Cys Leu 
            20                  25                  30          


Leu Ser Leu Leu Pro Ser Gly Phe Met Ser Leu Asp Asn Asn Gly Thr 
        35                  40                  45              


Ala Thr Pro Glu Leu Pro Thr Gln Gly Thr Phe Ser Asn Val Ser Thr 
    50                  55                  60                  


Asn Val Ser Tyr Gln Glu Thr Thr Thr Pro Ser Thr Leu Gly Ser Thr 
65                  70                  75                  80  


Ser Leu His Pro Val Ser Gln His Gly Asn Glu Ala Thr Thr Asn Ile 
                85                  90                  95      


Thr Glu Thr Thr Val Lys Phe Thr Ser Thr Ser Val Ile Thr Ser Val 
            100                 105                 110         


Tyr Gly Asn Thr Asn Ser Ser Val Gln Ser Gln Thr Ser Val Ile Ser 
        115                 120                 125             


Thr Val Phe Thr Thr Pro Ala Asn Val Ser Thr Pro Glu Thr Thr Leu 
    130                 135                 140                 


Lys Pro Ser Leu Ser Pro Gly Asn Val Ser Asp Leu Ser Thr Thr Ser 
145                 150                 155                 160 


Thr Ser Leu Ala Thr Ser Pro Thr Lys Pro Tyr Thr Ser Ser Ser Pro 
                165                 170                 175     


Ile Leu Ser Asp Ile Lys Ala Glu Ile Lys Cys Ser Gly Ile Arg Glu 
            180                 185                 190         


Val Lys Leu Thr Gln Gly Ile Cys Leu Glu Gln Asn Lys Thr Ser Ser 
        195                 200                 205             


Cys Ala Glu Phe Lys Lys Asp Arg Gly Glu Gly Leu Ala Arg Val Leu 
    210                 215                 220                 


Cys Gly Glu Glu Gln Ala Asp Ala Asp Ala Gly Ala Gln Val Cys Ser 
225                 230                 235                 240 


Leu Leu Leu Ala Gln Ser Glu Val Arg Pro Gln Cys Leu Leu Leu Val 
                245                 250                 255     


Leu Ala Asn Arg Thr Glu Ile Ser Ser Lys Leu Gln Leu Met Lys Lys 
            260                 265                 270         


His Gln Ser Asp Leu Lys Lys Leu Gly Ile Leu Asp Phe Thr Glu Gln 
        275                 280                 285             


Asp Val Ala Ser His Gln Ser Tyr Ser Gln Lys Thr Leu Ile Ala Leu 
    290                 295                 300                 


Val Thr Ser Gly Ala Leu Leu Ala Val Leu Gly Ile Thr Gly Tyr Phe 
305                 310                 315                 320 


Leu Met Asn Arg Arg Ser Trp Ser Pro Ile 
                325                 330 


<210>  25
<211>  335
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  P2A-TrhCD34

<400>  25

Gly Ser Gly Ala Thr Asn Phe Ser Leu Leu Lys Gln Ala Gly Asp Val 
1               5                   10                  15      


Glu Glu Asn Pro Gly Pro Val Gly Pro Phe Glu Ala Met Pro Arg Gly 
            20                  25                  30          


Trp Thr Ala Leu Cys Leu Leu Ser Leu Leu Pro Ser Gly Phe Met Ser 
        35                  40                  45              


Leu Asp Asn Asn Gly Thr Ala Thr Pro Glu Leu Pro Thr Gln Gly Thr 
    50                  55                  60                  


Phe Ser Asn Val Ser Thr Asn Val Ser Tyr Gln Glu Thr Thr Thr Pro 
65                  70                  75                  80  


Ser Thr Leu Gly Ser Thr Ser Leu His Pro Val Ser Gln His Gly Asn 
                85                  90                  95      


Glu Ala Thr Thr Asn Ile Thr Glu Thr Thr Val Lys Phe Thr Ser Thr 
            100                 105                 110         


Ser Val Ile Thr Ser Val Tyr Gly Asn Thr Asn Ser Ser Val Gln Ser 
        115                 120                 125             


Gln Thr Ser Val Ile Ser Thr Val Phe Thr Thr Pro Ala Asn Val Ser 
    130                 135                 140                 


Thr Pro Glu Thr Thr Leu Lys Pro Ser Leu Ser Pro Gly Asn Val Ser 
145                 150                 155                 160 


Asp Leu Ser Thr Thr Ser Thr Ser Leu Ala Thr Ser Pro Thr Lys Pro 
                165                 170                 175     


Tyr Thr Ser Ser Ser Pro Ile Leu Ser Asp Ile Lys Ala Glu Ile Lys 
            180                 185                 190         


Cys Ser Gly Ile Arg Glu Val Lys Leu Thr Gln Gly Ile Cys Leu Glu 
        195                 200                 205             


Gln Asn Lys Thr Ser Ser Cys Ala Glu Phe Lys Lys Asp Arg Gly Glu 
    210                 215                 220                 


Gly Leu Ala Arg Val Leu Cys Gly Glu Glu Gln Ala Asp Ala Asp Ala 
225                 230                 235                 240 


Gly Ala Gln Val Cys Ser Leu Leu Leu Ala Gln Ser Glu Val Arg Pro 
                245                 250                 255     


Gln Cys Leu Leu Leu Val Leu Ala Asn Arg Thr Glu Ile Ser Ser Lys 
            260                 265                 270         


Leu Gln Leu Met Lys Lys His Gln Ser Asp Leu Lys Lys Leu Gly Ile 
        275                 280                 285             


Leu Asp Phe Thr Glu Gln Asp Val Ala Ser His Gln Ser Tyr Ser Gln 
    290                 295                 300                 


Lys Thr Leu Ile Ala Leu Val Thr Ser Gly Ala Leu Leu Ala Val Leu 
305                 310                 315                 320 


Gly Ile Thr Gly Tyr Phe Leu Met Asn Arg Arg Ser Trp Ser Pro 
                325                 330                 335 


<210>  26
<211>  710
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Human-Herpes Simplex Virus-1 (HSV) - thymidine kinase (TK)

<400>  26

Met Pro Arg Gly Trp Thr Ala Leu Cys Leu Leu Ser Leu Leu Pro Ser 
1               5                   10                  15      


Gly Phe Met Ser Leu Asp Asn Asn Gly Thr Ala Thr Pro Glu Leu Pro 
            20                  25                  30          


Thr Gln Gly Thr Phe Ser Asn Val Ser Thr Asn Val Ser Tyr Gln Glu 
        35                  40                  45              


Thr Thr Thr Pro Ser Thr Leu Gly Ser Thr Ser Leu His Pro Val Ser 
    50                  55                  60                  


Gln His Gly Asn Glu Ala Thr Thr Asn Ile Thr Glu Thr Thr Val Lys 
65                  70                  75                  80  


Phe Thr Ser Thr Ser Val Ile Thr Ser Val Tyr Gly Asn Thr Asn Ser 
                85                  90                  95      


Ser Val Gln Ser Gln Thr Ser Val Ile Ser Thr Val Phe Thr Thr Pro 
            100                 105                 110         


Ala Asn Val Ser Thr Pro Glu Thr Thr Leu Lys Pro Ser Leu Ser Pro 
        115                 120                 125             


Gly Asn Val Ser Asp Leu Ser Thr Thr Ser Thr Ser Leu Ala Thr Ser 
    130                 135                 140                 


Pro Thr Lys Pro Tyr Thr Ser Ser Ser Pro Ile Leu Ser Asp Ile Lys 
145                 150                 155                 160 


Ala Glu Ile Lys Cys Ser Gly Ile Arg Glu Val Lys Leu Thr Gln Gly 
                165                 170                 175     


Ile Cys Leu Glu Gln Asn Lys Thr Ser Ser Cys Ala Glu Phe Lys Lys 
            180                 185                 190         


Asp Arg Gly Glu Gly Leu Ala Arg Val Leu Cys Gly Glu Glu Gln Ala 
        195                 200                 205             


Asp Ala Asp Ala Gly Ala Gln Val Cys Ser Leu Leu Leu Ala Gln Ser 
    210                 215                 220                 


Glu Val Arg Pro Gln Cys Leu Leu Leu Val Leu Ala Asn Arg Thr Glu 
225                 230                 235                 240 


Ile Ser Ser Lys Leu Gln Leu Met Lys Lys His Gln Ser Asp Leu Lys 
                245                 250                 255     


Lys Leu Gly Ile Leu Asp Phe Thr Glu Gln Asp Val Ala Ser His Gln 
            260                 265                 270         


Ser Tyr Ser Gln Lys Thr Leu Ile Ala Leu Val Thr Ser Gly Ala Leu 
        275                 280                 285             


Leu Ala Val Leu Gly Ile Thr Gly Tyr Phe Leu Met Asn Arg Arg Ser 
    290                 295                 300                 


Trp Ser Pro Thr Gly Glu Gly Gly Gly Gly Gly Asp Leu Gly Gly Val 
305                 310                 315                 320 


Lys Leu Pro His Leu Phe Gly Lys Arg Leu Val Glu Ala Arg Met Ala 
                325                 330                 335     


Ser Tyr Pro Cys His Gln His Ala Ser Ala Phe Asp Gln Ala Ala Arg 
            340                 345                 350         


Ser Arg Gly His Ser Asn Arg Arg Thr Ala Leu Arg Pro Arg Arg Gln 
        355                 360                 365             


Gln Glu Ala Thr Glu Val Arg Leu Glu Gln Lys Met Pro Thr Leu Leu 
    370                 375                 380                 


Arg Val Tyr Ile Asp Gly Pro His Gly Met Gly Lys Thr Thr Thr Thr 
385                 390                 395                 400 


Gln Leu Leu Val Ala Leu Gly Ser Arg Asp Asp Ile Val Tyr Val Pro 
                405                 410                 415     


Glu Pro Met Thr Tyr Trp Gln Val Leu Gly Ala Ser Glu Thr Ile Ala 
            420                 425                 430         


Asn Ile Tyr Thr Thr Gln His Arg Leu Asp Gln Gly Glu Ile Ser Ala 
        435                 440                 445             


Gly Asp Ala Ala Val Val Met Thr Ser Ala Gln Ile Thr Met Gly Met 
    450                 455                 460                 


Pro Tyr Ala Val Thr Asp Ala Val Leu Ala Pro His Val Gly Gly Glu 
465                 470                 475                 480 


Ala Gly Ser Ser His Ala Pro Pro Pro Ala Leu Thr Leu Leu Leu Asp 
                485                 490                 495     


Arg His Pro Ile Ala Val Met Leu Cys Tyr Pro Ala Ala Arg Tyr Leu 
            500                 505                 510         


Met Gly Ser Met Thr Pro Gln Ala Val Leu Ala Phe Val Ala Leu Ile 
        515                 520                 525             


Pro Pro Thr Leu Pro Gly Thr Asn Ile Val Leu Gly Ala Leu Pro Glu 
    530                 535                 540                 


Asp Arg His Ile Asp Arg Leu Ala Lys Arg Gln Arg Pro Gly Glu Arg 
545                 550                 555                 560 


Leu Asp Leu Ala Met Leu Ala Ala Ile Arg Arg Val Tyr Gly Leu Leu 
                565                 570                 575     


Ala Asn Thr Val Arg Tyr Leu Gln Gly Gly Gly Ser Trp Trp Glu Asp 
            580                 585                 590         


Trp Gly Gln Leu Ser Gly Thr Ala Val Pro Pro Gln Gly Ala Glu Pro 
        595                 600                 605             


Gln Ser Asn Ala Gly Pro Arg Pro His Ile Gly Asp Thr Leu Phe Thr 
    610                 615                 620                 


Leu Phe Arg Ala Pro Glu Leu Leu Ala Pro Asn Gly Asp Leu Tyr Asn 
625                 630                 635                 640 


Val Phe Ala Trp Ala Leu Asp Val Leu Ala Lys Arg Leu Arg Pro Met 
                645                 650                 655     


His Val Phe Ile Leu Asp Tyr Asp Gln Ser Pro Ala Gly Cys Arg Asp 
            660                 665                 670         


Ala Leu Leu Gln Leu Thr Ser Gly Met Val Gln Thr His Val Thr Thr 
        675                 680                 685             


Pro Gly Ser Ile Pro Thr Ile Cys Asp Leu Ala Arg Thr Phe Ala Arg 
    690                 695                 700                 


Glu Met Gly Glu Ala Asn 
705                 710 


<210>  27
<211>  120
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  CD2 heavy chain variable region (1)

<400>  27

Glu Val Lys Leu Glu Glu Ser Gly Ala Glu Leu Val Lys Pro Gly Ala 
1               5                   10                  15      


Ser Val Lys Leu Ser Cys Arg Thr Ser Gly Phe Asn Ile Lys Asp Thr 
            20                  25                  30          


Tyr Ile His Trp Val Lys Gln Arg Pro Glu Gln Gly Leu Lys Trp Ile 
        35                  40                  45              


Gly Arg Ile Asp Pro Ala Asn Gly Asn Thr Lys Tyr Asp Pro Lys Phe 
    50                  55                  60                  


Gln Asp Lys Ala Thr Val Thr Ala Asp Thr Ser Ser Asn Thr Ala Tyr 
65                  70                  75                  80  


Leu Gln Leu Ser Ser Leu Thr Ser Glu Asp Thr Ala Val Tyr Tyr Cys 
                85                  90                  95      


Val Thr Tyr Ala Tyr Asp Gly Asn Trp Tyr Phe Asp Val Trp Gly Ala 
            100                 105                 110         


Gly Thr Ala Val Thr Val Ser Ser 
        115                 120 


<210>  28
<211>  108
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  CD2 light chain variable region (1)

<400>  28

Asp Ile Lys Met Thr Gln Ser Pro Ser Ser Met Tyr Val Ser Leu Gly 
1               5                   10                  15      


Glu Arg Val Thr Ile Thr Cys Lys Ala Ser Gln Asp Ile Asn Ser Phe 
            20                  25                  30          


Leu Ser Trp Phe Gln Gln Lys Pro Gly Lys Ser Pro Lys Thr Leu Ile 
        35                  40                  45              


Tyr Arg Ala Asn Arg Leu Val Asp Gly Val Pro Ser Arg Phe Ser Gly 
    50                  55                  60                  


Ser Gly Ser Gly Gln Asp Tyr Ser Leu Thr Ile Ser Ser Leu Glu Tyr 
65                  70                  75                  80  


Glu Asp Met Glu Ile Tyr Tyr Cys Leu Gln Tyr Asp Glu Phe Pro Tyr 
                85                  90                  95      


Thr Phe Gly Gly Gly Thr Lys Leu Glu Met Lys Arg 
            100                 105             


<210>  29
<211>  121
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  CD2 heavy chain variable region (2)

<400>  29

Glu Val Gln Leu Glu Glu Ser Gly Ala Glu Leu Val Arg Pro Gly Thr 
1               5                   10                  15      


Ser Val Lys Leu Ser Cys Lys Ala Ser Gly Tyr Thr Phe Thr Ser Tyr 
            20                  25                  30          


Trp Met His Trp Ile Lys Gln Arg Pro Glu Gln Gly Leu Glu Trp Ile 
        35                  40                  45              


Gly Arg Ile Asp Pro Tyr Asp Ser Glu Thr His Tyr Asn Glu Lys Phe 
    50                  55                  60                  


Lys Asp Lys Ala Ile Leu Ser Val Asp Lys Ser Ser Ser Thr Ala Tyr 
65                  70                  75                  80  


Ile Gln Leu Ser Ser Leu Thr Ser Asp Asp Ser Ala Val Tyr Tyr Cys 
                85                  90                  95      


Ser Arg Arg Asp Ala Lys Tyr Asp Gly Tyr Ala Leu Asp Tyr Trp Gly 
            100                 105                 110         


Gln Gly Thr Ser Val Thr Val Ser Ser 
        115                 120     


<210>  30
<211>  113
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  CD2 light chain variable region (2)

<400>  30

Asp Ile Val Met Thr Gln Ala Ala Pro Ser Val Pro Val Thr Pro Gly 
1               5                   10                  15      


Glu Ser Val Ser Ile Ser Cys Arg Ser Ser Lys Thr Leu Leu His Ser 
            20                  25                  30          


Asn Gly Asn Thr Tyr Leu Tyr Trp Phe Leu Gln Arg Pro Gly Gln Ser 
        35                  40                  45              


Pro Gln Val Leu Ile Tyr Arg Met Ser Asn Leu Ala Ser Gly Val Pro 
    50                  55                  60                  


Asn Arg Phe Ser Gly Ser Gly Ser Glu Thr Thr Phe Thr Leu Arg Ile 
65                  70                  75                  80  


Ser Arg Val Glu Ala Glu Asp Val Gly Ile Tyr Tyr Cys Met Gln His 
                85                  90                  95      


Leu Glu Tyr Pro Tyr Thr Phe Gly Gly Gly Thr Lys Leu Glu Ile Glu 
            100                 105                 110         


Arg 
    


<210>  31
<211>  121
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  CD3 heavy chain variable region (OKT 3)

<400>  31

Gly Ser Gln Val Gln Leu Gln Gln Ser Gly Ala Glu Leu Ala Arg Pro 
1               5                   10                  15      


Gly Ala Ser Val Lys Met Ser Cys Lys Ala Ser Gly Tyr Thr Phe Thr 
            20                  25                  30          


Arg Tyr Thr Met His Trp Val Lys Gln Arg Pro Gly Gln Gly Leu Glu 
        35                  40                  45              


Trp Ile Gly Tyr Ile Asn Pro Ser Arg Gly Tyr Thr Asn Tyr Asn Gln 
    50                  55                  60                  


Lys Phe Lys Asp Lys Ala Thr Leu Thr Thr Asp Lys Ser Ser Ser Thr 
65                  70                  75                  80  


Ala Tyr Met Gln Leu Ser Ser Leu Thr Ser Glu Asp Ser Ala Val Tyr 
                85                  90                  95      


Tyr Cys Ala Arg Tyr Tyr Asp Asp His Tyr Cys Leu Asp Tyr Trp Gly 
            100                 105                 110         


Gln Gly Thr Thr Leu Thr Val Ser Ser 
        115                 120     


<210>  32
<211>  107
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  CD3 light chain variable region (OKT 3)

<400>  32

Gln Ile Val Leu Thr Gln Ser Pro Ala Ile Met Ser Ala Ser Pro Gly 
1               5                   10                  15      


Glu Lys Val Thr Met Thr Cys Ser Ala Ser Ser Ser Val Ser Tyr Met 
            20                  25                  30          


Asn Trp Tyr Gln Gln Lys Ser Gly Thr Ser Pro Lys Arg Trp Ile Tyr 
        35                  40                  45              


Asp Thr Ser Lys Leu Ala Ser Gly Val Pro Ala His Phe Arg Gly Ser 
    50                  55                  60                  


Gly Ser Gly Thr Ser Tyr Ser Leu Thr Ile Ser Gly Met Glu Ala Glu 
65                  70                  75                  80  


Asp Ala Ala Thr Tyr Tyr Cys Gln Gln Trp Ser Ser Asn Pro Phe Thr 
                85                  90                  95      


Phe Gly Ser Gly Thr Lys Leu Glu Ile Asn Arg 
            100                 105         


<210>  33
<211>  122
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  CD3 heavy chain variable region (UCHT1)

<400>  33

Glu Val Gln Leu Val Glu Ser Gly Gly Gly Leu Val Gln Pro Gly Gly 
1               5                   10                  15      


Ser Leu Arg Leu Ser Cys Ala Ala Ser Gly Tyr Ser Phe Thr Gly Tyr 
            20                  25                  30          


Thr Met Asn Trp Val Arg Gln Ala Pro Gly Lys Cys Leu Glu Trp Val 
        35                  40                  45              


Ala Leu Ile Asn Pro Tyr Lys Gly Val Ser Thr Tyr Asn Gln Lys Phe 
    50                  55                  60                  


Lys Asp Arg Phe Thr Ile Ser Val Asp Lys Ser Lys Asn Thr Ala Tyr 
65                  70                  75                  80  


Leu Gln Met Asn Ser Leu Arg Ala Glu Asp Thr Ala Val Tyr Tyr Cys 
                85                  90                  95      


Ala Arg Ser Gly Tyr Tyr Gly Asp Ser Asp Trp Tyr Phe Asp Val Trp 
            100                 105                 110         


Gly Gln Gly Thr Leu Val Thr Val Ser Ser 
        115                 120         


<210>  34
<211>  107
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  CD3 heavy chain variable region (UCHT1)

<400>  34

Asp Ile Gln Met Thr Gln Ser Pro Ser Ser Leu Ser Ala Ser Val Gly 
1               5                   10                  15      


Asp Arg Val Thr Ile Thr Cys Arg Ala Ser Gln Asp Ile Arg Asn Tyr 
            20                  25                  30          


Leu Asn Trp Tyr Gln Gln Lys Pro Gly Lys Ala Pro Lys Leu Leu Ile 
        35                  40                  45              


Tyr Tyr Thr Ser Arg Leu Glu Ser Gly Val Pro Ser Arg Phe Ser Gly 
    50                  55                  60                  


Ser Gly Ser Gly Thr Asp Tyr Thr Leu Thr Ile Ser Ser Leu Gln Pro 
65                  70                  75                  80  


Glu Asp Phe Ala Thr Tyr Tyr Cys Gln Gln Gly Asn Thr Leu Pro Trp 
                85                  90                  95      


Thr Phe Gly Cys Gly Thr Lys Val Glu Ile Lys 
            100                 105         


<210>  35
<211>  116
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  CD7 heavy chain variable region

<400>  35

Glu Val Gln Leu Val Glu Ser Gly Gly Gly Leu Val Lys Pro Gly Gly 
1               5                   10                  15      


Ser Leu Lys Leu Ser Cys Ala Ala Ser Gly Leu Thr Phe Ser Ser Tyr 
            20                  25                  30          


Ala Met Ser Trp Val Arg Gln Thr Pro Glu Lys Arg Leu Glu Trp Val 
        35                  40                  45              


Ala Ser Ile Ser Ser Gly Gly Phe Thr Tyr Tyr Pro Asp Ser Val Lys 
    50                  55                  60                  


Gly Arg Phe Thr Ile Ser Arg Asp Asn Ala Arg Asn Ile Leu Tyr Leu 
65                  70                  75                  80  


Gln Met Ser Ser Leu Arg Ser Glu Asp Thr Ala Met Tyr Tyr Cys Ala 
                85                  90                  95      


Arg Asp Glu Val Arg Gly Tyr Leu Asp Val Trp Gly Ala Gly Thr Thr 
            100                 105                 110         


Val Thr Val Ser 
        115     


<210>  36
<211>  108
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  CD7 light chain variable region

<400>  36

Asp Ile Gln Met Thr Gln Thr Thr Ser Ser Leu Ser Ala Ser Leu Gly 
1               5                   10                  15      


Asp Arg Val Thr Ile Ser Cys Ser Ala Ser Gln Gly Ile Ser Asn Tyr 
            20                  25                  30          


Leu Asn Trp Tyr Gln Gln Lys Pro Asp Gly Thr Val Lys Leu Leu Ile 
        35                  40                  45              


Tyr Tyr Thr Ser Ser Leu His Ser Gly Val Pro Ser Arg Phe Ser Gly 
    50                  55                  60                  


Ser Gly Ser Gly Thr Asp Tyr Ser Leu Thr Ile Ser Asn Leu Glu Pro 
65                  70                  75                  80  


Glu Asp Ile Ala Thr Tyr Tyr Cys Gln Gln Tyr Ser Lys Leu Pro Tyr 
                85                  90                  95      


Thr Phe Gly Gly Gly Thr Lys Leu Glu Ile Lys Arg 
            100                 105             


<210>  37
<211>  119
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  FLT3 heavy chain variable region

<400>  37

Glu Val Gln Leu Val Gln Ser Gly Ala Glu Val Lys Lys Pro Gly Ala 
1               5                   10                  15      


Ser Val Lys Val Ser Cys Lys Ala Ser Gly Tyr Thr Phe Thr Ser Tyr 
            20                  25                  30          


Tyr Met His Trp Val Arg Gln Ala Pro Gly Gln Gly Leu Glu Trp Met 
        35                  40                  45              


Gly Ile Ile Asn Pro Ser Gly Gly Ser Thr Ser Tyr Ala Gln Lys Phe 
    50                  55                  60                  


Gln Gly Arg Val Thr Met Thr Arg Asp Thr Ser Thr Ser Thr Val Tyr 
65                  70                  75                  80  


Met Glu Leu Ser Ser Leu Arg Ser Glu Asp Thr Ala Val Tyr Tyr Cys 
                85                  90                  95      


Ala Arg Gly Val Gly Ala His Asp Ala Phe Asp Ile Trp Gly Gln Gly 
            100                 105                 110         


Thr Thr Val Thr Val Ser Ser 
        115                 


<210>  38
<211>  112
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  FLT3 light chain variable region

<400>  38

Asp Val Val Met Thr Gln Ser Pro Leu Ser Leu Pro Val Thr Pro Gly 
1               5                   10                  15      


Glu Pro Ala Ser Ile Ser Cys Arg Ser Ser Gln Ser Leu Leu His Ser 
            20                  25                  30          


Asn Gly Asn Asn Tyr Leu Asp Trp Tyr Leu Gln Lys Pro Gly Gln Ser 
        35                  40                  45              


Pro Gln Leu Leu Ile Tyr Leu Gly Ser Asn Arg Ala Ser Gly Val Pro 
    50                  55                  60                  


Asp Arg Phe Ser Gly Ser Gly Ser Asp Thr Asp Phe Thr Leu Gln Ile 
65                  70                  75                  80  


Ser Arg Val Glu Ala Glu Asp Val Gly Val Tyr Tyr Cys Met Gln Gly 
                85                  90                  95      


Thr His Pro Ala Ile Ser Phe Gly Gln Gly Thr Arg Leu Glu Ile Lys 
            100                 105                 110         


<210>  39
<211>  122
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  FLT3 heavy chain variable region

<400>  39

Glu Val Gln Leu Val Gln Ser Gly Ala Glu Val Lys Lys Pro Gly Ser 
1               5                   10                  15      


Ser Val Lys Val Ser Cys Lys Ala Ser Gly Gly Thr Phe Ser Ser Tyr 
            20                  25                  30          


Ala Ile Ser Trp Val Arg Gln Ala Pro Gly Gln Gly Leu Glu Trp Met 
        35                  40                  45              


Gly Gly Ile Ile Pro Ile Phe Gly Thr Ala Asn Tyr Ala Gln Lys Phe 
    50                  55                  60                  


Gln Gly Arg Val Thr Ile Thr Ala Asp Lys Ser Thr Ser Thr Ala Tyr 
65                  70                  75                  80  


Met Glu Leu Ser Ser Leu Arg Ser Glu Asp Thr Ala Val Tyr Tyr Cys 
                85                  90                  95      


Ala Thr Phe Ala Leu Phe Gly Phe Arg Glu Gln Ala Phe Asp Ile Trp 
            100                 105                 110         


Gly Gln Gly Thr Thr Val Thr Val Ser Ser 
        115                 120         


<210>  40
<211>  107
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  FLT3 light chain variable region

<400>  40

Asp Ile Gln Met Thr Gln Ser Pro Ser Ser Leu Ser Ala Ser Val Gly 
1               5                   10                  15      


Asp Arg Val Thr Ile Thr Cys Arg Ala Ser Gln Ser Ile Ser Ser Tyr 
            20                  25                  30          


Leu Asn Trp Tyr Gln Gln Lys Pro Gly Lys Ala Pro Lys Leu Leu Ile 
        35                  40                  45              


Tyr Ala Ala Ser Ser Leu Gln Ser Gly Val Pro Ser Arg Phe Ser Gly 
    50                  55                  60                  


Ser Gly Ser Gly Thr Asp Phe Thr Leu Thr Ile Ser Ser Leu Gln Pro 
65                  70                  75                  80  


Glu Asp Leu Ala Thr Tyr Tyr Cys Gln Gln Ser Tyr Ser Thr Pro Phe 
                85                  90                  95      


Thr Phe Gly Pro Gly Thr Lys Val Asp Ile Lys 
            100                 105         


<210>  41
<211>  118
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  FLT3 heavy chain variable region

<400>  41

Glu Val Gln Leu Val Gln Ser Gly Ala Glu Val Lys Lys Pro Gly Ala 
1               5                   10                  15      


Ser Val Lys Val Ser Cys Lys Ala Ser Gly Tyr Thr Phe Thr Ser Tyr 
            20                  25                  30          


Tyr Met His Trp Ala Arg Gln Ala Pro Gly Gln Gly Leu Glu Trp Met 
        35                  40                  45              


Gly Ile Ile Asn Pro Ser Gly Gly Ser Thr Ser Tyr Ala Gln Lys Phe 
    50                  55                  60                  


Gln Gly Arg Val Thr Met Thr Arg Asp Thr Ser Thr Ser Thr Val Tyr 
65                  70                  75                  80  


Met Glu Leu Ser Ser Leu Arg Ser Glu Asp Thr Ala Val Tyr Tyr Cys 
                85                  90                  95      


Ala Arg Val Val Ala Ala Ala Val Ala Asp Tyr Trp Gly Gln Gly Thr 
            100                 105                 110         


Leu Val Thr Val Ser Ser 
        115             


<210>  42
<211>  112
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  FLT3 light chain variable region

<400>  42

Asp Val Val Met Thr Gln Ser Pro Leu Ser Leu Pro Val Thr Pro Gly 
1               5                   10                  15      


Glu Pro Ala Ser Ile Ser Cys Arg Ser Ser Gln Ser Leu Leu His Ser 
            20                  25                  30          


Asn Gly Tyr Asn Tyr Leu Asp Trp Tyr Leu Gln Lys Pro Gly Gln Ser 
        35                  40                  45              


Pro Gln Leu Leu Ile Tyr Leu Gly Ser Asn Arg Ala Ser Gly Val Pro 
    50                  55                  60                  


Asp Arg Phe Ser Gly Ser Gly Ser Gly Thr Asp Phe Thr Leu Lys Ile 
65                  70                  75                  80  


Ser Arg Val Glu Ala Glu Asp Val Gly Val Tyr Tyr Cys Met Gln Ser 
                85                  90                  95      


Leu Gln Thr Pro Phe Thr Phe Gly Pro Gly Thr Lys Val Asp Ile Lys 
            100                 105                 110         


<210>  43
<211>  120
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  CS1 heavy chain variable region

<400>  43

Gln Val Gln Leu Gln Gln Pro Gly Ala Glu Leu Val Arg Pro Gly Ala 
1               5                   10                  15      


Ser Val Lys Leu Ser Cys Lys Ala Ser Gly Tyr Ser Phe Thr Thr Tyr 
            20                  25                  30          


Trp Met Asn Trp Val Lys Gln Arg Pro Gly Gln Gly Leu Glu Trp Ile 
        35                  40                  45              


Gly Met Ile His Pro Ser Asp Ser Glu Thr Arg Leu Asn Gln Lys Phe 
    50                  55                  60                  


Lys Asp Lys Ala Thr Leu Thr Val Asp Lys Ser Ser Ser Thr Ala Tyr 
65                  70                  75                  80  


Met Gln Leu Ser Ser Pro Thr Ser Glu Asp Ser Ala Val Tyr Tyr Cys 
                85                  90                  95      


Ala Arg Ser Thr Met Ile Ala Thr Arg Ala Met Asp Tyr Trp Gly Gln 
            100                 105                 110         


Gly Thr Ser Val Thr Val Ser Ser 
        115                 120 


<210>  44
<211>  107
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  CS1 light chain variable region

<400>  44

Asp Ile Val Met Thr Gln Ser Gln Lys Ser Met Ser Thr Ser Val Gly 
1               5                   10                  15      


Asp Arg Val Ser Ile Thr Cys Lys Ala Ser Gln Asp Val Ile Thr Gly 
            20                  25                  30          


Val Ala Trp Tyr Gln Gln Lys Pro Gly Gln Ser Pro Lys Leu Leu Ile 
        35                  40                  45              


Tyr Ser Ala Ser Tyr Arg Tyr Thr Gly Val Pro Asp Arg Phe Thr Gly 
    50                  55                  60                  


Ser Gly Ser Gly Thr Asp Phe Thr Phe Thr Ile Ser Asn Val Gln Ala 
65                  70                  75                  80  


Glu Asp Leu Ala Val Tyr Tyr Cys Gln Gln His Tyr Ser Thr Pro Leu 
                85                  90                  95      


Thr Phe Gly Ala Gly Thr Lys Leu Glu Leu Lys 
            100                 105         


<210>  45
<211>  120
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  CD33 heavy chain variable region

<400>  45

Gln Val Gln Leu Gln Gln Pro Gly Ala Glu Val Val Lys Pro Gly Ala 
1               5                   10                  15      


Ser Val Lys Met Ser Cys Lys Ala Ser Gly Tyr Thr Phe Thr Ser Tyr 
            20                  25                  30          


Tyr Ile His Trp Ile Lys Gln Thr Pro Gly Gln Gly Leu Glu Trp Val 
        35                  40                  45              


Gly Val Ile Tyr Pro Gly Asn Asp Asp Ile Ser Tyr Asn Gln Lys Phe 
    50                  55                  60                  


Gln Gly Lys Ala Thr Leu Thr Ala Asp Lys Ser Ser Thr Thr Ala Tyr 
65                  70                  75                  80  


Met Gln Leu Ser Ser Leu Thr Ser Glu Asp Ser Ala Val Tyr Tyr Cys 
                85                  90                  95      


Ala Arg Glu Val Arg Leu Arg Tyr Phe Asp Val Trp Gly Gln Gly Thr 
            100                 105                 110         


Thr Val Thr Val Ser Ser Ser Gly 
        115                 120 


<210>  46
<211>  115
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  CD33 light chain variable region

<400>  46

Gly Ser Glu Ile Val Leu Thr Gln Ser Pro Gly Ser Leu Ala Val Ser 
1               5                   10                  15      


Pro Gly Glu Arg Val Thr Met Ser Cys Lys Ser Ser Gln Ser Val Phe 
            20                  25                  30          


Phe Ser Ser Ser Gln Lys Asn Tyr Leu Ala Trp Tyr Gln Gln Ile Pro 
        35                  40                  45              


Gly Gln Ser Pro Arg Leu Leu Ile Tyr Trp Ala Ser Thr Arg Glu Ser 
    50                  55                  60                  


Gly Val Pro Asp Arg Phe Thr Gly Ser Gly Ser Gly Thr Asp Phe Thr 
65                  70                  75                  80  


Leu Thr Ile Ser Ser Val Gln Pro Glu Asp Leu Ala Ile Tyr Tyr Cys 
                85                  90                  95      


His Gln Tyr Leu Ser Ser Arg Thr Phe Gly Gln Gly Thr Lys Leu Glu 
            100                 105                 110         


Ile Lys Arg 
        115 


<210>  47
<211>  483
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  CAR Amino Acid Sequence

<400>  47

Met Ala Leu Pro Val Thr Ala Leu Leu Leu Pro Leu Ala Leu Leu Leu 
1               5                   10                  15      


His Ala Ala Arg Pro Asp Ile Val Met Thr Gln Ala Ala Pro Ser Val 
            20                  25                  30          


Pro Val Thr Pro Gly Glu Ser Val Ser Ile Ser Cys Arg Ser Ser Lys 
        35                  40                  45              


Thr Leu Leu His Ser Asn Gly Asn Thr Tyr Leu Tyr Trp Phe Leu Gln 
    50                  55                  60                  


Arg Pro Gly Gln Ser Pro Gln Val Leu Ile Tyr Arg Met Ser Asn Leu 
65                  70                  75                  80  


Ala Ser Gly Val Pro Asn Arg Phe Ser Gly Ser Gly Ser Glu Thr Thr 
                85                  90                  95      


Phe Thr Leu Arg Ile Ser Arg Val Glu Ala Glu Asp Val Gly Ile Tyr 
            100                 105                 110         


Tyr Cys Met Gln His Leu Glu Tyr Pro Tyr Thr Phe Gly Gly Gly Thr 
        115                 120                 125             


Lys Leu Glu Ile Glu Arg Gly Gly Gly Gly Ser Glu Val Gln Leu Glu 
    130                 135                 140                 


Glu Ser Gly Ala Glu Leu Val Arg Pro Gly Thr Ser Val Lys Leu Ser 
145                 150                 155                 160 


Cys Lys Ala Ser Gly Tyr Thr Phe Thr Ser Tyr Trp Met His Trp Ile 
                165                 170                 175     


Lys Gln Arg Pro Glu Gln Gly Leu Glu Trp Ile Gly Arg Ile Asp Pro 
            180                 185                 190         


Tyr Asp Ser Glu Thr His Tyr Asn Glu Lys Phe Lys Asp Lys Ala Ile 
        195                 200                 205             


Leu Ser Val Asp Lys Ser Ser Ser Thr Ala Tyr Ile Gln Leu Ser Ser 
    210                 215                 220                 


Leu Thr Ser Asp Asp Ser Ala Val Tyr Tyr Cys Ser Arg Arg Asp Ala 
225                 230                 235                 240 


Lys Tyr Asp Gly Tyr Ala Leu Asp Tyr Trp Gly Gln Gly Thr Ser Val 
                245                 250                 255     


Thr Val Ser Ser Thr Pro Ala Pro Arg Pro Pro Thr Pro Ala Pro Thr 
            260                 265                 270         


Ile Ala Ser Gln Pro Leu Ser Leu Arg Pro Glu Ala Cys Arg Pro Ala 
        275                 280                 285             


Ala Gly Gly Ala Val His Thr Arg Gly Leu Asp Phe Ala Cys Asp Phe 
    290                 295                 300                 


Trp Val Leu Val Val Val Gly Gly Val Leu Ala Cys Tyr Ser Leu Leu 
305                 310                 315                 320 


Val Thr Val Ala Phe Ile Ile Phe Trp Val Arg Ser Lys Arg Ser Arg 
                325                 330                 335     


Leu Leu His Ser Asp Tyr Met Asn Met Thr Pro Arg Arg Pro Gly Pro 
            340                 345                 350         


Thr Arg Lys His Tyr Gln Pro Tyr Ala Pro Pro Arg Asp Phe Ala Ala 
        355                 360                 365             


Tyr Arg Ser Arg Val Lys Phe Ser Arg Ser Ala Asp Ala Pro Ala Tyr 
    370                 375                 380                 


Lys Gln Gly Gln Asn Gln Leu Tyr Asn Glu Leu Asn Leu Gly Arg Arg 
385                 390                 395                 400 


Glu Glu Tyr Asp Val Leu Asp Lys Arg Arg Gly Arg Asp Pro Glu Met 
                405                 410                 415     


Gly Gly Lys Pro Arg Arg Lys Asn Pro Gln Glu Gly Leu Tyr Asn Glu 
            420                 425                 430         


Leu Gln Lys Asp Lys Met Ala Glu Ala Tyr Ser Glu Ile Gly Met Lys 
        435                 440                 445             


Gly Glu Arg Arg Arg Gly Lys Gly His Asp Gly Leu Tyr Gln Gly Leu 
    450                 455                 460                 


Ser Thr Ala Thr Lys Asp Thr Tyr Asp Ala Leu His Met Gln Ala Leu 
465                 470                 475                 480 


Pro Pro Arg 
            


<210>  48
<211>  484
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  CAR Amino Acid Sequence

<400>  48

Met Ala Leu Pro Val Thr Ala Leu Leu Leu Pro Leu Ala Leu Leu Leu 
1               5                   10                  15      


His Ala Ala Arg Pro Asp Ile Val Met Thr Gln Ala Ala Pro Ser Val 
            20                  25                  30          


Pro Val Thr Pro Gly Glu Ser Val Ser Ile Ser Cys Arg Ser Ser Lys 
        35                  40                  45              


Thr Leu Leu His Ser Asn Gly Asn Thr Tyr Leu Tyr Trp Phe Leu Gln 
    50                  55                  60                  


Arg Pro Gly Gln Ser Pro Gln Val Leu Ile Tyr Arg Met Ser Asn Leu 
65                  70                  75                  80  


Ala Ser Gly Val Pro Asn Arg Phe Ser Gly Ser Gly Ser Glu Thr Thr 
                85                  90                  95      


Phe Thr Leu Arg Ile Ser Arg Val Glu Ala Glu Asp Val Gly Ile Tyr 
            100                 105                 110         


Tyr Cys Met Gln His Leu Glu Tyr Pro Tyr Thr Phe Gly Gly Gly Thr 
        115                 120                 125             


Lys Leu Glu Ile Glu Arg Gly Gly Gly Gly Ser Glu Val Gln Leu Glu 
    130                 135                 140                 


Glu Ser Gly Ala Glu Leu Val Arg Pro Gly Thr Ser Val Lys Leu Ser 
145                 150                 155                 160 


Cys Lys Ala Ser Gly Tyr Thr Phe Thr Ser Tyr Trp Met His Trp Ile 
                165                 170                 175     


Lys Gln Arg Pro Glu Gln Gly Leu Glu Trp Ile Gly Arg Ile Asp Pro 
            180                 185                 190         


Tyr Asp Ser Glu Thr His Tyr Asn Glu Lys Phe Lys Asp Lys Ala Ile 
        195                 200                 205             


Leu Ser Val Asp Lys Ser Ser Ser Thr Ala Tyr Ile Gln Leu Ser Ser 
    210                 215                 220                 


Leu Thr Ser Asp Asp Ser Ala Val Tyr Tyr Cys Ser Arg Arg Asp Ala 
225                 230                 235                 240 


Lys Tyr Asp Gly Tyr Ala Leu Asp Tyr Trp Gly Gln Gly Thr Ser Val 
                245                 250                 255     


Thr Val Ser Ser Thr Pro Ala Pro Arg Pro Pro Thr Pro Ala Pro Thr 
            260                 265                 270         


Ile Ala Ser Gln Pro Leu Ser Leu Arg Pro Glu Ala Cys Arg Pro Ala 
        275                 280                 285             


Ala Gly Gly Ala Val His Thr Arg Gly Leu Asp Phe Ala Cys Asp Phe 
    290                 295                 300                 


Trp Val Leu Val Val Val Gly Gly Val Leu Ala Cys Tyr Ser Leu Leu 
305                 310                 315                 320 


Val Thr Val Ala Phe Ile Ile Phe Trp Val Lys Arg Gly Arg Lys Lys 
                325                 330                 335     


Leu Leu Tyr Ile Phe Lys Gln Pro Phe Met Arg Pro Val Gln Thr Thr 
            340                 345                 350         


Gln Glu Glu Asp Gly Cys Ser Cys Arg Phe Pro Glu Glu Glu Glu Gly 
        355                 360                 365             


Gly Cys Glu Leu Arg Val Lys Phe Ser Arg Ser Ala Asp Ala Pro Ala 
    370                 375                 380                 


Tyr Lys Gln Gly Gln Asn Gln Leu Tyr Asn Glu Leu Asn Leu Gly Arg 
385                 390                 395                 400 


Arg Glu Glu Tyr Asp Val Leu Asp Lys Arg Arg Gly Arg Asp Pro Glu 
                405                 410                 415     


Met Gly Gly Lys Pro Arg Arg Lys Asn Pro Gln Glu Gly Leu Tyr Asn 
            420                 425                 430         


Glu Leu Gln Lys Asp Lys Met Ala Glu Ala Tyr Ser Glu Ile Gly Met 
        435                 440                 445             


Lys Gly Glu Arg Arg Arg Gly Lys Gly His Asp Gly Leu Tyr Gln Gly 
    450                 455                 460                 


Leu Ser Thr Ala Thr Lys Asp Thr Tyr Asp Ala Leu His Met Gln Ala 
465                 470                 475                 480 


Leu Pro Pro Arg 
                


<210>  49
<211>  488
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  CAR Amino Acid Sequence

<400>  49

Met Ala Leu Pro Val Thr Ala Leu Leu Leu Pro Leu Ala Leu Leu Leu 
1               5                   10                  15      


His Ala Ala Arg Pro Asp Ile Val Met Thr Gln Ala Ala Pro Ser Val 
            20                  25                  30          


Pro Val Thr Pro Gly Glu Ser Val Ser Ile Ser Cys Arg Ser Ser Lys 
        35                  40                  45              


Thr Leu Leu His Ser Asn Gly Asn Thr Tyr Leu Tyr Trp Phe Leu Gln 
    50                  55                  60                  


Arg Pro Gly Gln Ser Pro Gln Val Leu Ile Tyr Arg Met Ser Asn Leu 
65                  70                  75                  80  


Ala Ser Gly Val Pro Asn Arg Phe Ser Gly Ser Gly Ser Glu Thr Thr 
                85                  90                  95      


Phe Thr Leu Arg Ile Ser Arg Val Glu Ala Glu Asp Val Gly Ile Tyr 
            100                 105                 110         


Tyr Cys Met Gln His Leu Glu Tyr Pro Tyr Thr Phe Gly Gly Gly Thr 
        115                 120                 125             


Lys Leu Glu Ile Glu Arg Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser 
    130                 135                 140                 


Glu Val Gln Leu Glu Glu Ser Gly Ala Glu Leu Val Arg Pro Gly Thr 
145                 150                 155                 160 


Ser Val Lys Leu Ser Cys Lys Ala Ser Gly Tyr Thr Phe Thr Ser Tyr 
                165                 170                 175     


Trp Met His Trp Ile Lys Gln Arg Pro Glu Gln Gly Leu Glu Trp Ile 
            180                 185                 190         


Gly Arg Ile Asp Pro Tyr Asp Ser Glu Thr His Tyr Asn Glu Lys Phe 
        195                 200                 205             


Lys Asp Lys Ala Ile Leu Ser Val Asp Lys Ser Ser Ser Thr Ala Tyr 
    210                 215                 220                 


Ile Gln Leu Ser Ser Leu Thr Ser Asp Asp Ser Ala Val Tyr Tyr Cys 
225                 230                 235                 240 


Ser Arg Arg Asp Ala Lys Tyr Asp Gly Tyr Ala Leu Asp Tyr Trp Gly 
                245                 250                 255     


Gln Gly Thr Ser Val Thr Val Ser Ser Thr Pro Ala Pro Arg Pro Pro 
            260                 265                 270         


Thr Pro Ala Pro Thr Ile Ala Ser Gln Pro Leu Ser Leu Arg Pro Glu 
        275                 280                 285             


Ala Cys Arg Pro Ala Ala Gly Gly Ala Val His Thr Arg Gly Leu Asp 
    290                 295                 300                 


Phe Ala Cys Asp Phe Trp Val Leu Val Val Val Gly Gly Val Leu Ala 
305                 310                 315                 320 


Cys Tyr Ser Leu Leu Val Thr Val Ala Phe Ile Ile Phe Trp Val Arg 
                325                 330                 335     


Ser Lys Arg Ser Arg Leu Leu His Ser Asp Tyr Met Asn Met Thr Pro 
            340                 345                 350         


Arg Arg Pro Gly Pro Thr Arg Lys His Tyr Gln Pro Tyr Ala Pro Pro 
        355                 360                 365             


Arg Asp Phe Ala Ala Tyr Arg Ser Arg Val Lys Phe Ser Arg Ser Ala 
    370                 375                 380                 


Asp Ala Pro Ala Tyr Lys Gln Gly Gln Asn Gln Leu Tyr Asn Glu Leu 
385                 390                 395                 400 


Asn Leu Gly Arg Arg Glu Glu Tyr Asp Val Leu Asp Lys Arg Arg Gly 
                405                 410                 415     


Arg Asp Pro Glu Met Gly Gly Lys Pro Arg Arg Lys Asn Pro Gln Glu 
            420                 425                 430         


Gly Leu Tyr Asn Glu Leu Gln Lys Asp Lys Met Ala Glu Ala Tyr Ser 
        435                 440                 445             


Glu Ile Gly Met Lys Gly Glu Arg Arg Arg Gly Lys Gly His Asp Gly 
    450                 455                 460                 


Leu Tyr Gln Gly Leu Ser Thr Ala Thr Lys Asp Thr Tyr Asp Ala Leu 
465                 470                 475                 480 


His Met Gln Ala Leu Pro Pro Arg 
                485             


<210>  50
<211>  489
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  CAR Amino Acid Sequence

<400>  50

Met Ala Leu Pro Val Thr Ala Leu Leu Leu Pro Leu Ala Leu Leu Leu 
1               5                   10                  15      


His Ala Ala Arg Pro Asp Ile Val Met Thr Gln Ala Ala Pro Ser Val 
            20                  25                  30          


Pro Val Thr Pro Gly Glu Ser Val Ser Ile Ser Cys Arg Ser Ser Lys 
        35                  40                  45              


Thr Leu Leu His Ser Asn Gly Asn Thr Tyr Leu Tyr Trp Phe Leu Gln 
    50                  55                  60                  


Arg Pro Gly Gln Ser Pro Gln Val Leu Ile Tyr Arg Met Ser Asn Leu 
65                  70                  75                  80  


Ala Ser Gly Val Pro Asn Arg Phe Ser Gly Ser Gly Ser Glu Thr Thr 
                85                  90                  95      


Phe Thr Leu Arg Ile Ser Arg Val Glu Ala Glu Asp Val Gly Ile Tyr 
            100                 105                 110         


Tyr Cys Met Gln His Leu Glu Tyr Pro Tyr Thr Phe Gly Gly Gly Thr 
        115                 120                 125             


Lys Leu Glu Ile Glu Arg Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser 
    130                 135                 140                 


Glu Val Gln Leu Glu Glu Ser Gly Ala Glu Leu Val Arg Pro Gly Thr 
145                 150                 155                 160 


Ser Val Lys Leu Ser Cys Lys Ala Ser Gly Tyr Thr Phe Thr Ser Tyr 
                165                 170                 175     


Trp Met His Trp Ile Lys Gln Arg Pro Glu Gln Gly Leu Glu Trp Ile 
            180                 185                 190         


Gly Arg Ile Asp Pro Tyr Asp Ser Glu Thr His Tyr Asn Glu Lys Phe 
        195                 200                 205             


Lys Asp Lys Ala Ile Leu Ser Val Asp Lys Ser Ser Ser Thr Ala Tyr 
    210                 215                 220                 


Ile Gln Leu Ser Ser Leu Thr Ser Asp Asp Ser Ala Val Tyr Tyr Cys 
225                 230                 235                 240 


Ser Arg Arg Asp Ala Lys Tyr Asp Gly Tyr Ala Leu Asp Tyr Trp Gly 
                245                 250                 255     


Gln Gly Thr Ser Val Thr Val Ser Ser Thr Pro Ala Pro Arg Pro Pro 
            260                 265                 270         


Thr Pro Ala Pro Thr Ile Ala Ser Gln Pro Leu Ser Leu Arg Pro Glu 
        275                 280                 285             


Ala Cys Arg Pro Ala Ala Gly Gly Ala Val His Thr Arg Gly Leu Asp 
    290                 295                 300                 


Phe Ala Cys Asp Phe Trp Val Leu Val Val Val Gly Gly Val Leu Ala 
305                 310                 315                 320 


Cys Tyr Ser Leu Leu Val Thr Val Ala Phe Ile Ile Phe Trp Val Lys 
                325                 330                 335     


Arg Gly Arg Lys Lys Leu Leu Tyr Ile Phe Lys Gln Pro Phe Met Arg 
            340                 345                 350         


Pro Val Gln Thr Thr Gln Glu Glu Asp Gly Cys Ser Cys Arg Phe Pro 
        355                 360                 365             


Glu Glu Glu Glu Gly Gly Cys Glu Leu Arg Val Lys Phe Ser Arg Ser 
    370                 375                 380                 


Ala Asp Ala Pro Ala Tyr Lys Gln Gly Gln Asn Gln Leu Tyr Asn Glu 
385                 390                 395                 400 


Leu Asn Leu Gly Arg Arg Glu Glu Tyr Asp Val Leu Asp Lys Arg Arg 
                405                 410                 415     


Gly Arg Asp Pro Glu Met Gly Gly Lys Pro Arg Arg Lys Asn Pro Gln 
            420                 425                 430         


Glu Gly Leu Tyr Asn Glu Leu Gln Lys Asp Lys Met Ala Glu Ala Tyr 
        435                 440                 445             


Ser Glu Ile Gly Met Lys Gly Glu Arg Arg Arg Gly Lys Gly His Asp 
    450                 455                 460                 


Gly Leu Tyr Gln Gly Leu Ser Thr Ala Thr Lys Asp Thr Tyr Asp Ala 
465                 470                 475                 480 


Leu His Met Gln Ala Leu Pro Pro Arg 
                485                 


<210>  51
<211>  493
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  CAR Amino Acid Sequence

<400>  51

Met Ala Leu Pro Val Thr Ala Leu Leu Leu Pro Leu Ala Leu Leu Leu 
1               5                   10                  15      


His Ala Ala Arg Pro Asp Ile Val Met Thr Gln Ala Ala Pro Ser Val 
            20                  25                  30          


Pro Val Thr Pro Gly Glu Ser Val Ser Ile Ser Cys Arg Ser Ser Lys 
        35                  40                  45              


Thr Leu Leu His Ser Asn Gly Asn Thr Tyr Leu Tyr Trp Phe Leu Gln 
    50                  55                  60                  


Arg Pro Gly Gln Ser Pro Gln Val Leu Ile Tyr Arg Met Ser Asn Leu 
65                  70                  75                  80  


Ala Ser Gly Val Pro Asn Arg Phe Ser Gly Ser Gly Ser Glu Thr Thr 
                85                  90                  95      


Phe Thr Leu Arg Ile Ser Arg Val Glu Ala Glu Asp Val Gly Ile Tyr 
            100                 105                 110         


Tyr Cys Met Gln His Leu Glu Tyr Pro Tyr Thr Phe Gly Gly Gly Thr 
        115                 120                 125             


Lys Leu Glu Ile Glu Arg Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser 
    130                 135                 140                 


Gly Gly Gly Gly Ser Glu Val Gln Leu Glu Glu Ser Gly Ala Glu Leu 
145                 150                 155                 160 


Val Arg Pro Gly Thr Ser Val Lys Leu Ser Cys Lys Ala Ser Gly Tyr 
                165                 170                 175     


Thr Phe Thr Ser Tyr Trp Met His Trp Ile Lys Gln Arg Pro Glu Gln 
            180                 185                 190         


Gly Leu Glu Trp Ile Gly Arg Ile Asp Pro Tyr Asp Ser Glu Thr His 
        195                 200                 205             


Tyr Asn Glu Lys Phe Lys Asp Lys Ala Ile Leu Ser Val Asp Lys Ser 
    210                 215                 220                 


Ser Ser Thr Ala Tyr Ile Gln Leu Ser Ser Leu Thr Ser Asp Asp Ser 
225                 230                 235                 240 


Ala Val Tyr Tyr Cys Ser Arg Arg Asp Ala Lys Tyr Asp Gly Tyr Ala 
                245                 250                 255     


Leu Asp Tyr Trp Gly Gln Gly Thr Ser Val Thr Val Ser Ser Thr Pro 
            260                 265                 270         


Ala Pro Arg Pro Pro Thr Pro Ala Pro Thr Ile Ala Ser Gln Pro Leu 
        275                 280                 285             


Ser Leu Arg Pro Glu Ala Cys Arg Pro Ala Ala Gly Gly Ala Val His 
    290                 295                 300                 


Thr Arg Gly Leu Asp Phe Ala Cys Asp Phe Trp Val Leu Val Val Val 
305                 310                 315                 320 


Gly Gly Val Leu Ala Cys Tyr Ser Leu Leu Val Thr Val Ala Phe Ile 
                325                 330                 335     


Ile Phe Trp Val Arg Ser Lys Arg Ser Arg Leu Leu His Ser Asp Tyr 
            340                 345                 350         


Met Asn Met Thr Pro Arg Arg Pro Gly Pro Thr Arg Lys His Tyr Gln 
        355                 360                 365             


Pro Tyr Ala Pro Pro Arg Asp Phe Ala Ala Tyr Arg Ser Arg Val Lys 
    370                 375                 380                 


Phe Ser Arg Ser Ala Asp Ala Pro Ala Tyr Lys Gln Gly Gln Asn Gln 
385                 390                 395                 400 


Leu Tyr Asn Glu Leu Asn Leu Gly Arg Arg Glu Glu Tyr Asp Val Leu 
                405                 410                 415     


Asp Lys Arg Arg Gly Arg Asp Pro Glu Met Gly Gly Lys Pro Arg Arg 
            420                 425                 430         


Lys Asn Pro Gln Glu Gly Leu Tyr Asn Glu Leu Gln Lys Asp Lys Met 
        435                 440                 445             


Ala Glu Ala Tyr Ser Glu Ile Gly Met Lys Gly Glu Arg Arg Arg Gly 
    450                 455                 460                 


Lys Gly His Asp Gly Leu Tyr Gln Gly Leu Ser Thr Ala Thr Lys Asp 
465                 470                 475                 480 


Thr Tyr Asp Ala Leu His Met Gln Ala Leu Pro Pro Arg 
                485                 490             


<210>  52
<211>  494
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  CAR Amino Acid Sequence

<400>  52

Met Ala Leu Pro Val Thr Ala Leu Leu Leu Pro Leu Ala Leu Leu Leu 
1               5                   10                  15      


His Ala Ala Arg Pro Asp Ile Val Met Thr Gln Ala Ala Pro Ser Val 
            20                  25                  30          


Pro Val Thr Pro Gly Glu Ser Val Ser Ile Ser Cys Arg Ser Ser Lys 
        35                  40                  45              


Thr Leu Leu His Ser Asn Gly Asn Thr Tyr Leu Tyr Trp Phe Leu Gln 
    50                  55                  60                  


Arg Pro Gly Gln Ser Pro Gln Val Leu Ile Tyr Arg Met Ser Asn Leu 
65                  70                  75                  80  


Ala Ser Gly Val Pro Asn Arg Phe Ser Gly Ser Gly Ser Glu Thr Thr 
                85                  90                  95      


Phe Thr Leu Arg Ile Ser Arg Val Glu Ala Glu Asp Val Gly Ile Tyr 
            100                 105                 110         


Tyr Cys Met Gln His Leu Glu Tyr Pro Tyr Thr Phe Gly Gly Gly Thr 
        115                 120                 125             


Lys Leu Glu Ile Glu Arg Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser 
    130                 135                 140                 


Gly Gly Gly Gly Ser Glu Val Gln Leu Glu Glu Ser Gly Ala Glu Leu 
145                 150                 155                 160 


Val Arg Pro Gly Thr Ser Val Lys Leu Ser Cys Lys Ala Ser Gly Tyr 
                165                 170                 175     


Thr Phe Thr Ser Tyr Trp Met His Trp Ile Lys Gln Arg Pro Glu Gln 
            180                 185                 190         


Gly Leu Glu Trp Ile Gly Arg Ile Asp Pro Tyr Asp Ser Glu Thr His 
        195                 200                 205             


Tyr Asn Glu Lys Phe Lys Asp Lys Ala Ile Leu Ser Val Asp Lys Ser 
    210                 215                 220                 


Ser Ser Thr Ala Tyr Ile Gln Leu Ser Ser Leu Thr Ser Asp Asp Ser 
225                 230                 235                 240 


Ala Val Tyr Tyr Cys Ser Arg Arg Asp Ala Lys Tyr Asp Gly Tyr Ala 
                245                 250                 255     


Leu Asp Tyr Trp Gly Gln Gly Thr Ser Val Thr Val Ser Ser Thr Pro 
            260                 265                 270         


Ala Pro Arg Pro Pro Thr Pro Ala Pro Thr Ile Ala Ser Gln Pro Leu 
        275                 280                 285             


Ser Leu Arg Pro Glu Ala Cys Arg Pro Ala Ala Gly Gly Ala Val His 
    290                 295                 300                 


Thr Arg Gly Leu Asp Phe Ala Cys Asp Phe Trp Val Leu Val Val Val 
305                 310                 315                 320 


Gly Gly Val Leu Ala Cys Tyr Ser Leu Leu Val Thr Val Ala Phe Ile 
                325                 330                 335     


Ile Phe Trp Val Lys Arg Gly Arg Lys Lys Leu Leu Tyr Ile Phe Lys 
            340                 345                 350         


Gln Pro Phe Met Arg Pro Val Gln Thr Thr Gln Glu Glu Asp Gly Cys 
        355                 360                 365             


Ser Cys Arg Phe Pro Glu Glu Glu Glu Gly Gly Cys Glu Leu Arg Val 
    370                 375                 380                 


Lys Phe Ser Arg Ser Ala Asp Ala Pro Ala Tyr Lys Gln Gly Gln Asn 
385                 390                 395                 400 


Gln Leu Tyr Asn Glu Leu Asn Leu Gly Arg Arg Glu Glu Tyr Asp Val 
                405                 410                 415     


Leu Asp Lys Arg Arg Gly Arg Asp Pro Glu Met Gly Gly Lys Pro Arg 
            420                 425                 430         


Arg Lys Asn Pro Gln Glu Gly Leu Tyr Asn Glu Leu Gln Lys Asp Lys 
        435                 440                 445             


Met Ala Glu Ala Tyr Ser Glu Ile Gly Met Lys Gly Glu Arg Arg Arg 
    450                 455                 460                 


Gly Lys Gly His Asp Gly Leu Tyr Gln Gly Leu Ser Thr Ala Thr Lys 
465                 470                 475                 480 


Asp Thr Tyr Asp Ala Leu His Met Gln Ala Leu Pro Pro Arg 
                485                 490                 


<210>  53
<211>  498
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  CAR Amino Acid Sequence

<400>  53

Met Ala Leu Pro Val Thr Ala Leu Leu Leu Pro Leu Ala Leu Leu Leu 
1               5                   10                  15      


His Ala Ala Arg Pro Asp Ile Val Met Thr Gln Ala Ala Pro Ser Val 
            20                  25                  30          


Pro Val Thr Pro Gly Glu Ser Val Ser Ile Ser Cys Arg Ser Ser Lys 
        35                  40                  45              


Thr Leu Leu His Ser Asn Gly Asn Thr Tyr Leu Tyr Trp Phe Leu Gln 
    50                  55                  60                  


Arg Pro Gly Gln Ser Pro Gln Val Leu Ile Tyr Arg Met Ser Asn Leu 
65                  70                  75                  80  


Ala Ser Gly Val Pro Asn Arg Phe Ser Gly Ser Gly Ser Glu Thr Thr 
                85                  90                  95      


Phe Thr Leu Arg Ile Ser Arg Val Glu Ala Glu Asp Val Gly Ile Tyr 
            100                 105                 110         


Tyr Cys Met Gln His Leu Glu Tyr Pro Tyr Thr Phe Gly Gly Gly Thr 
        115                 120                 125             


Lys Leu Glu Ile Glu Arg Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser 
    130                 135                 140                 


Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser Glu Val Gln Leu Glu Glu 
145                 150                 155                 160 


Ser Gly Ala Glu Leu Val Arg Pro Gly Thr Ser Val Lys Leu Ser Cys 
                165                 170                 175     


Lys Ala Ser Gly Tyr Thr Phe Thr Ser Tyr Trp Met His Trp Ile Lys 
            180                 185                 190         


Gln Arg Pro Glu Gln Gly Leu Glu Trp Ile Gly Arg Ile Asp Pro Tyr 
        195                 200                 205             


Asp Ser Glu Thr His Tyr Asn Glu Lys Phe Lys Asp Lys Ala Ile Leu 
    210                 215                 220                 


Ser Val Asp Lys Ser Ser Ser Thr Ala Tyr Ile Gln Leu Ser Ser Leu 
225                 230                 235                 240 


Thr Ser Asp Asp Ser Ala Val Tyr Tyr Cys Ser Arg Arg Asp Ala Lys 
                245                 250                 255     


Tyr Asp Gly Tyr Ala Leu Asp Tyr Trp Gly Gln Gly Thr Ser Val Thr 
            260                 265                 270         


Val Ser Ser Thr Pro Ala Pro Arg Pro Pro Thr Pro Ala Pro Thr Ile 
        275                 280                 285             


Ala Ser Gln Pro Leu Ser Leu Arg Pro Glu Ala Cys Arg Pro Ala Ala 
    290                 295                 300                 


Gly Gly Ala Val His Thr Arg Gly Leu Asp Phe Ala Cys Asp Phe Trp 
305                 310                 315                 320 


Val Leu Val Val Val Gly Gly Val Leu Ala Cys Tyr Ser Leu Leu Val 
                325                 330                 335     


Thr Val Ala Phe Ile Ile Phe Trp Val Arg Ser Lys Arg Ser Arg Leu 
            340                 345                 350         


Leu His Ser Asp Tyr Met Asn Met Thr Pro Arg Arg Pro Gly Pro Thr 
        355                 360                 365             


Arg Lys His Tyr Gln Pro Tyr Ala Pro Pro Arg Asp Phe Ala Ala Tyr 
    370                 375                 380                 


Arg Ser Arg Val Lys Phe Ser Arg Ser Ala Asp Ala Pro Ala Tyr Lys 
385                 390                 395                 400 


Gln Gly Gln Asn Gln Leu Tyr Asn Glu Leu Asn Leu Gly Arg Arg Glu 
                405                 410                 415     


Glu Tyr Asp Val Leu Asp Lys Arg Arg Gly Arg Asp Pro Glu Met Gly 
            420                 425                 430         


Gly Lys Pro Arg Arg Lys Asn Pro Gln Glu Gly Leu Tyr Asn Glu Leu 
        435                 440                 445             


Gln Lys Asp Lys Met Ala Glu Ala Tyr Ser Glu Ile Gly Met Lys Gly 
    450                 455                 460                 


Glu Arg Arg Arg Gly Lys Gly His Asp Gly Leu Tyr Gln Gly Leu Ser 
465                 470                 475                 480 


Thr Ala Thr Lys Asp Thr Tyr Asp Ala Leu His Met Gln Ala Leu Pro 
                485                 490                 495     


Pro Arg 
        


<210>  54
<211>  614
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  CAR Amino Acid Sequence

<400>  54

Met Ala Leu Pro Val Thr Ala Leu Leu Leu Pro Leu Ala Leu Leu Leu 
1               5                   10                  15      


His Ala Ala Arg Pro Asp Ile Val Met Thr Gln Ala Ala Pro Ser Val 
            20                  25                  30          


Pro Val Thr Pro Gly Glu Ser Val Ser Ile Ser Cys Arg Ser Ser Lys 
        35                  40                  45              


Thr Leu Leu His Ser Asn Gly Asn Thr Tyr Leu Tyr Trp Phe Leu Gln 
    50                  55                  60                  


Arg Pro Gly Gln Ser Pro Gln Val Leu Ile Tyr Arg Met Ser Asn Leu 
65                  70                  75                  80  


Ala Ser Gly Val Pro Asn Arg Phe Ser Gly Ser Gly Ser Glu Thr Thr 
                85                  90                  95      


Phe Thr Leu Arg Ile Ser Arg Val Glu Ala Glu Asp Val Gly Ile Tyr 
            100                 105                 110         


Tyr Cys Met Gln His Leu Glu Tyr Pro Tyr Thr Phe Gly Gly Gly Thr 
        115                 120                 125             


Lys Leu Glu Ile Glu Arg Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser 
    130                 135                 140                 


Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser Glu Val Gln Leu Glu Glu 
145                 150                 155                 160 


Ser Gly Ala Glu Leu Val Arg Pro Gly Thr Ser Val Lys Leu Ser Cys 
                165                 170                 175     


Lys Ala Ser Gly Tyr Thr Phe Thr Ser Tyr Trp Met His Trp Ile Lys 
            180                 185                 190         


Gln Arg Pro Glu Gln Gly Leu Glu Trp Ile Gly Arg Ile Asp Pro Tyr 
        195                 200                 205             


Asp Ser Glu Thr His Tyr Asn Glu Lys Phe Lys Asp Lys Ala Ile Leu 
    210                 215                 220                 


Ser Val Asp Lys Ser Ser Ser Thr Ala Tyr Ile Gln Leu Ser Ser Leu 
225                 230                 235                 240 


Thr Ser Asp Asp Ser Ala Val Tyr Tyr Cys Ser Arg Arg Asp Ala Lys 
                245                 250                 255     


Tyr Asp Gly Tyr Ala Leu Asp Tyr Trp Gly Gln Gly Thr Ser Val Thr 
            260                 265                 270         


Val Ser Ser Thr Pro Ala Pro Arg Pro Pro Thr Pro Ala Pro Thr Ile 
        275                 280                 285             


Ala Ser Gln Pro Leu Ser Leu Arg Pro Glu Ala Cys Arg Pro Ala Ala 
    290                 295                 300                 


Gly Gly Ala Val His Thr Arg Gly Leu Asp Phe Ala Cys Asp Phe Trp 
305                 310                 315                 320 


Val Leu Val Val Val Gly Gly Val Leu Ala Cys Tyr Ser Leu Leu Val 
                325                 330                 335     


Thr Val Ala Phe Ile Ile Phe Trp Val Arg Ser Lys Arg Ser Arg Leu 
            340                 345                 350         


Leu His Ser Asp Tyr Met Asn Met Thr Pro Arg Arg Pro Gly Pro Thr 
        355                 360                 365             


Arg Lys His Tyr Gln Pro Tyr Ala Pro Pro Arg Asp Phe Ala Ala Tyr 
    370                 375                 380                 


Arg Ser Lys Arg Lys Lys Gln Arg Ser Arg Arg Asn Asp Glu Glu Leu 
385                 390                 395                 400 


Glu Thr Arg Ala His Arg Val Ala Thr Glu Glu Arg Gly Arg Lys Pro 
                405                 410                 415     


His Gln Ile Pro Ala Ser Thr Pro Gln Asn Pro Ala Thr Ser Gln His 
            420                 425                 430         


Pro Pro Pro Pro Pro Gly His Arg Ser Gln Ala Pro Ser His Arg Pro 
        435                 440                 445             


Pro Pro Pro Gly His Arg Val Gln His Gln Pro Gln Lys Arg Pro Pro 
    450                 455                 460                 


Ala Pro Ser Gly Thr Gln Val His Gln Gln Lys Gly Pro Pro Leu Pro 
465                 470                 475                 480 


Arg Pro Arg Val Gln Pro Lys Pro Pro His Gly Ala Ala Glu Asn Ser 
                485                 490                 495     


Leu Ser Pro Ser Ser Asn Arg Val Lys Phe Ser Arg Ser Ala Asp Ala 
            500                 505                 510         


Pro Ala Tyr Lys Gln Gly Gln Asn Gln Leu Tyr Asn Glu Leu Asn Leu 
        515                 520                 525             


Gly Arg Arg Glu Glu Tyr Asp Val Leu Asp Lys Arg Arg Gly Arg Asp 
    530                 535                 540                 


Pro Glu Met Gly Gly Lys Pro Arg Arg Lys Asn Pro Gln Glu Gly Leu 
545                 550                 555                 560 


Tyr Asn Glu Leu Gln Lys Asp Lys Met Ala Glu Ala Tyr Ser Glu Ile 
                565                 570                 575     


Gly Met Lys Gly Glu Arg Arg Arg Gly Lys Gly His Asp Gly Leu Tyr 
            580                 585                 590         


Gln Gly Leu Ser Thr Ala Thr Lys Asp Thr Tyr Asp Ala Leu His Met 
        595                 600                 605             


Gln Ala Leu Pro Pro Arg 
    610                 


<210>  55
<211>  538
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  CAR Amino Acid Sequence

<400>  55

Met Ala Leu Pro Val Thr Ala Leu Leu Leu Pro Leu Ala Leu Leu Leu 
1               5                   10                  15      


His Ala Ala Arg Pro Asp Ile Val Met Thr Gln Ala Ala Pro Ser Val 
            20                  25                  30          


Pro Val Thr Pro Gly Glu Ser Val Ser Ile Ser Cys Arg Ser Ser Lys 
        35                  40                  45              


Thr Leu Leu His Ser Asn Gly Asn Thr Tyr Leu Tyr Trp Phe Leu Gln 
    50                  55                  60                  


Arg Pro Gly Gln Ser Pro Gln Val Leu Ile Tyr Arg Met Ser Asn Leu 
65                  70                  75                  80  


Ala Ser Gly Val Pro Asn Arg Phe Ser Gly Ser Gly Ser Glu Thr Thr 
                85                  90                  95      


Phe Thr Leu Arg Ile Ser Arg Val Glu Ala Glu Asp Val Gly Ile Tyr 
            100                 105                 110         


Tyr Cys Met Gln His Leu Glu Tyr Pro Tyr Thr Phe Gly Gly Gly Thr 
        115                 120                 125             


Lys Leu Glu Ile Glu Arg Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser 
    130                 135                 140                 


Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser Glu Val Gln Leu Glu Glu 
145                 150                 155                 160 


Ser Gly Ala Glu Leu Val Arg Pro Gly Thr Ser Val Lys Leu Ser Cys 
                165                 170                 175     


Lys Ala Ser Gly Tyr Thr Phe Thr Ser Tyr Trp Met His Trp Ile Lys 
            180                 185                 190         


Gln Arg Pro Glu Gln Gly Leu Glu Trp Ile Gly Arg Ile Asp Pro Tyr 
        195                 200                 205             


Asp Ser Glu Thr His Tyr Asn Glu Lys Phe Lys Asp Lys Ala Ile Leu 
    210                 215                 220                 


Ser Val Asp Lys Ser Ser Ser Thr Ala Tyr Ile Gln Leu Ser Ser Leu 
225                 230                 235                 240 


Thr Ser Asp Asp Ser Ala Val Tyr Tyr Cys Ser Arg Arg Asp Ala Lys 
                245                 250                 255     


Tyr Asp Gly Tyr Ala Leu Asp Tyr Trp Gly Gln Gly Thr Ser Val Thr 
            260                 265                 270         


Val Ser Ser Thr Pro Ala Pro Arg Pro Pro Thr Pro Ala Pro Thr Ile 
        275                 280                 285             


Ala Ser Gln Pro Leu Ser Leu Arg Pro Glu Ala Cys Arg Pro Ala Ala 
    290                 295                 300                 


Gly Gly Ala Val His Thr Arg Gly Leu Asp Phe Ala Cys Asp Phe Trp 
305                 310                 315                 320 


Val Leu Val Val Val Gly Gly Val Leu Ala Cys Tyr Ser Leu Leu Val 
                325                 330                 335     


Thr Val Ala Phe Ile Ile Phe Trp Val Cys Val Arg Cys Arg His Arg 
            340                 345                 350         


Arg Arg Gln Ala Glu Arg Met Ser Gln Ile Lys Arg Leu Leu Ser Glu 
        355                 360                 365             


Lys Lys Thr Cys Gln Cys Pro His Arg Phe Gln Lys Thr Cys Ser Pro 
    370                 375                 380                 


Ile Arg Ser Lys Arg Ser Arg Leu Leu His Ser Asp Tyr Met Asn Met 
385                 390                 395                 400 


Thr Pro Arg Arg Pro Gly Pro Thr Arg Lys His Tyr Gln Pro Tyr Ala 
                405                 410                 415     


Pro Pro Arg Asp Phe Ala Ala Tyr Arg Ser Arg Val Lys Phe Ser Arg 
            420                 425                 430         


Ser Ala Asp Ala Pro Ala Tyr Lys Gln Gly Gln Asn Gln Leu Tyr Asn 
        435                 440                 445             


Glu Leu Asn Leu Gly Arg Arg Glu Glu Tyr Asp Val Leu Asp Lys Arg 
    450                 455                 460                 


Arg Gly Arg Asp Pro Glu Met Gly Gly Lys Pro Arg Arg Lys Asn Pro 
465                 470                 475                 480 


Gln Glu Gly Leu Tyr Asn Glu Leu Gln Lys Asp Lys Met Ala Glu Ala 
                485                 490                 495     


Tyr Ser Glu Ile Gly Met Lys Gly Glu Arg Arg Arg Gly Lys Gly His 
            500                 505                 510         


Asp Gly Leu Tyr Gln Gly Leu Ser Thr Ala Thr Lys Asp Thr Tyr Asp 
        515                 520                 525             


Ala Leu His Met Gln Ala Leu Pro Pro Arg 
    530                 535             


<210>  56
<211>  733
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  CAR Amino Acid Sequence

<400>  56

Met Ala Leu Pro Val Thr Ala Leu Leu Leu Pro Leu Ala Leu Leu Leu 
1               5                   10                  15      


His Ala Ala Arg Pro Asp Ile Val Met Thr Gln Ala Ala Pro Ser Val 
            20                  25                  30          


Pro Val Thr Pro Gly Glu Ser Val Ser Ile Ser Cys Arg Ser Ser Lys 
        35                  40                  45              


Thr Leu Leu His Ser Asn Gly Asn Thr Tyr Leu Tyr Trp Phe Leu Gln 
    50                  55                  60                  


Arg Pro Gly Gln Ser Pro Gln Val Leu Ile Tyr Arg Met Ser Asn Leu 
65                  70                  75                  80  


Ala Ser Gly Val Pro Asn Arg Phe Ser Gly Ser Gly Ser Glu Thr Thr 
                85                  90                  95      


Phe Thr Leu Arg Ile Ser Arg Val Glu Ala Glu Asp Val Gly Ile Tyr 
            100                 105                 110         


Tyr Cys Met Gln His Leu Glu Tyr Pro Tyr Thr Phe Gly Gly Gly Thr 
        115                 120                 125             


Lys Leu Glu Ile Glu Arg Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser 
    130                 135                 140                 


Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser Glu Val Gln Leu Glu Glu 
145                 150                 155                 160 


Ser Gly Ala Glu Leu Val Arg Pro Gly Thr Ser Val Lys Leu Ser Cys 
                165                 170                 175     


Lys Ala Ser Gly Tyr Thr Phe Thr Ser Tyr Trp Met His Trp Ile Lys 
            180                 185                 190         


Gln Arg Pro Glu Gln Gly Leu Glu Trp Ile Gly Arg Ile Asp Pro Tyr 
        195                 200                 205             


Asp Ser Glu Thr His Tyr Asn Glu Lys Phe Lys Asp Lys Ala Ile Leu 
    210                 215                 220                 


Ser Val Asp Lys Ser Ser Ser Thr Ala Tyr Ile Gln Leu Ser Ser Leu 
225                 230                 235                 240 


Thr Ser Asp Asp Ser Ala Val Tyr Tyr Cys Ser Arg Arg Asp Ala Lys 
                245                 250                 255     


Tyr Asp Gly Tyr Ala Leu Asp Tyr Trp Gly Gln Gly Thr Ser Val Thr 
            260                 265                 270         


Val Ser Ser Thr Pro Ala Pro Arg Pro Pro Thr Pro Ala Pro Thr Ile 
        275                 280                 285             


Ala Ser Gln Pro Leu Ser Leu Arg Pro Glu Ala Cys Arg Pro Ala Ala 
    290                 295                 300                 


Gly Gly Ala Val His Thr Arg Gly Leu Asp Phe Ala Cys Asp Phe Trp 
305                 310                 315                 320 


Val Leu Val Val Val Gly Gly Val Leu Ala Cys Tyr Ser Leu Leu Val 
                325                 330                 335     


Thr Val Ala Phe Ile Ile Phe Trp Val His Cys His Arg Leu Pro Gly 
            340                 345                 350         


Ser Tyr Asp Ser Thr Ser Ser Asp Ser Leu Tyr Pro Arg Gly Ile Gln 
        355                 360                 365             


Phe Lys Arg Pro His Thr Val Ala Pro Trp Pro Pro Ala Tyr Pro Pro 
    370                 375                 380                 


Val Thr Ser Tyr Pro Pro Leu Ser Gln Pro Asp Leu Leu Pro Ile Pro 
385                 390                 395                 400 


Arg Ser Pro Gln Pro Leu Gly Gly Ser His Arg Thr Pro Ser Ser Arg 
                405                 410                 415     


Arg Asp Ser Asp Gly Ala Asn Ser Val Ala Ser Tyr Glu Asn Glu Gly 
            420                 425                 430         


Ala Ser Gly Ile Arg Gly Ala Gln Ala Gly Trp Gly Val Trp Gly Pro 
        435                 440                 445             


Ser Trp Thr Arg Leu Thr Pro Val Ser Leu Pro Pro Glu Pro Ala Cys 
    450                 455                 460                 


Glu Asp Ala Asp Glu Asp Glu Asp Asp Tyr His Asn Pro Gly Tyr Leu 
465                 470                 475                 480 


Val Val Leu Pro Asp Ser Thr Pro Ala Thr Ser Thr Ala Ala Pro Ser 
                485                 490                 495     


Ala Pro Ala Leu Ser Thr Pro Gly Ile Arg Asp Ser Ala Phe Ser Met 
            500                 505                 510         


Glu Ser Ile Asp Asp Tyr Val Asn Val Pro Glu Ser Gly Glu Ser Ala 
        515                 520                 525             


Glu Ala Ser Leu Asp Gly Ser Arg Glu Tyr Val Asn Val Ser Gln Glu 
    530                 535                 540                 


Leu His Pro Gly Ala Ala Lys Thr Glu Pro Ala Ala Leu Ser Ser Gln 
545                 550                 555                 560 


Glu Ala Glu Glu Val Glu Glu Glu Gly Ala Pro Asp Tyr Glu Asn Leu 
                565                 570                 575     


Gln Glu Leu Asn Arg Ser Lys Arg Ser Arg Leu Leu His Ser Asp Tyr 
            580                 585                 590         


Met Asn Met Thr Pro Arg Arg Pro Gly Pro Thr Arg Lys His Tyr Gln 
        595                 600                 605             


Pro Tyr Ala Pro Pro Arg Asp Phe Ala Ala Tyr Arg Ser Arg Val Lys 
    610                 615                 620                 


Phe Ser Arg Ser Ala Asp Ala Pro Ala Tyr Lys Gln Gly Gln Asn Gln 
625                 630                 635                 640 


Leu Tyr Asn Glu Leu Asn Leu Gly Arg Arg Glu Glu Tyr Asp Val Leu 
                645                 650                 655     


Asp Lys Arg Arg Gly Arg Asp Pro Glu Met Gly Gly Lys Pro Arg Arg 
            660                 665                 670         


Lys Asn Pro Gln Glu Gly Leu Tyr Asn Glu Leu Gln Lys Asp Lys Met 
        675                 680                 685             


Ala Glu Ala Tyr Ser Glu Ile Gly Met Lys Gly Glu Arg Arg Arg Gly 
    690                 695                 700                 


Lys Gly His Asp Gly Leu Tyr Gln Gly Leu Ser Thr Ala Thr Lys Asp 
705                 710                 715                 720 


Thr Tyr Asp Ala Leu His Met Gln Ala Leu Pro Pro Arg 
                725                 730             


<210>  57
<211>  733
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  CAR Amino Acid Sequence

<400>  57

Met Ala Leu Pro Val Thr Ala Leu Leu Leu Pro Leu Ala Leu Leu Leu 
1               5                   10                  15      


His Ala Ala Arg Pro Asp Ile Val Met Thr Gln Ala Ala Pro Ser Val 
            20                  25                  30          


Pro Val Thr Pro Gly Glu Ser Val Ser Ile Ser Cys Arg Ser Ser Lys 
        35                  40                  45              


Thr Leu Leu His Ser Asn Gly Asn Thr Tyr Leu Tyr Trp Phe Leu Gln 
    50                  55                  60                  


Arg Pro Gly Gln Ser Pro Gln Val Leu Ile Tyr Arg Met Ser Asn Leu 
65                  70                  75                  80  


Ala Ser Gly Val Pro Asn Arg Phe Ser Gly Ser Gly Ser Glu Thr Thr 
                85                  90                  95      


Phe Thr Leu Arg Ile Ser Arg Val Glu Ala Glu Asp Val Gly Ile Tyr 
            100                 105                 110         


Tyr Cys Met Gln His Leu Glu Tyr Pro Tyr Thr Phe Gly Gly Gly Thr 
        115                 120                 125             


Lys Leu Glu Ile Glu Arg Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser 
    130                 135                 140                 


Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser Glu Val Gln Leu Glu Glu 
145                 150                 155                 160 


Ser Gly Ala Glu Leu Val Arg Pro Gly Thr Ser Val Lys Leu Ser Cys 
                165                 170                 175     


Lys Ala Ser Gly Tyr Thr Phe Thr Ser Tyr Trp Met His Trp Ile Lys 
            180                 185                 190         


Gln Arg Pro Glu Gln Gly Leu Glu Trp Ile Gly Arg Ile Asp Pro Tyr 
        195                 200                 205             


Asp Ser Glu Thr His Tyr Asn Glu Lys Phe Lys Asp Lys Ala Ile Leu 
    210                 215                 220                 


Ser Val Asp Lys Ser Ser Ser Thr Ala Tyr Ile Gln Leu Ser Ser Leu 
225                 230                 235                 240 


Thr Ser Asp Asp Ser Ala Val Tyr Tyr Cys Ser Arg Arg Asp Ala Lys 
                245                 250                 255     


Tyr Asp Gly Tyr Ala Leu Asp Tyr Trp Gly Gln Gly Thr Ser Val Thr 
            260                 265                 270         


Val Ser Ser Thr Pro Ala Pro Arg Pro Pro Thr Pro Ala Pro Thr Ile 
        275                 280                 285             


Ala Ser Gln Pro Leu Ser Leu Arg Pro Glu Ala Cys Arg Pro Ala Ala 
    290                 295                 300                 


Gly Gly Ala Val His Thr Arg Gly Leu Asp Phe Ala Cys Asp Phe Trp 
305                 310                 315                 320 


Val Leu Val Val Val Gly Gly Val Leu Ala Cys Tyr Ser Leu Leu Val 
                325                 330                 335     


Thr Val Ala Phe Ile Ile Phe Trp Val Arg Ser Lys Arg Ser Arg Leu 
            340                 345                 350         


Leu His Ser Asp Tyr Met Asn Met Thr Pro Arg Arg Pro Gly Pro Thr 
        355                 360                 365             


Arg Lys His Tyr Gln Pro Tyr Ala Pro Pro Arg Asp Phe Ala Ala Tyr 
    370                 375                 380                 


Arg Ser Arg Val Lys Phe Ser Arg Ser Ala Asp Ala Pro Ala Tyr Lys 
385                 390                 395                 400 


Gln Gly Gln Asn Gln Leu Tyr Asn Glu Leu Asn Leu Gly Arg Arg Glu 
                405                 410                 415     


Glu Tyr Asp Val Leu Asp Lys Arg Arg Gly Arg Asp Pro Glu Met Gly 
            420                 425                 430         


Gly Lys Pro Arg Arg Lys Asn Pro Gln Glu Gly Leu Tyr Asn Glu Leu 
        435                 440                 445             


Gln Lys Asp Lys Met Ala Glu Ala Tyr Ser Glu Ile Gly Met Lys Gly 
    450                 455                 460                 


Glu Arg Arg Arg Gly Lys Gly His Asp Gly Leu Tyr Gln Gly Leu Ser 
465                 470                 475                 480 


Thr Ala Thr Lys Asp Thr Tyr Asp Ala Leu His Met Gln Ala Leu Pro 
                485                 490                 495     


Pro Arg His Cys His Arg Leu Pro Gly Ser Tyr Asp Ser Thr Ser Ser 
            500                 505                 510         


Asp Ser Leu Tyr Pro Arg Gly Ile Gln Phe Lys Arg Pro His Thr Val 
        515                 520                 525             


Ala Pro Trp Pro Pro Ala Tyr Pro Pro Val Thr Ser Tyr Pro Pro Leu 
    530                 535                 540                 


Ser Gln Pro Asp Leu Leu Pro Ile Pro Arg Ser Pro Gln Pro Leu Gly 
545                 550                 555                 560 


Gly Ser His Arg Thr Pro Ser Ser Arg Arg Asp Ser Asp Gly Ala Asn 
                565                 570                 575     


Ser Val Ala Ser Tyr Glu Asn Glu Gly Ala Ser Gly Ile Arg Gly Ala 
            580                 585                 590         


Gln Ala Gly Trp Gly Val Trp Gly Pro Ser Trp Thr Arg Leu Thr Pro 
        595                 600                 605             


Val Ser Leu Pro Pro Glu Pro Ala Cys Glu Asp Ala Asp Glu Asp Glu 
    610                 615                 620                 


Asp Asp Tyr His Asn Pro Gly Tyr Leu Val Val Leu Pro Asp Ser Thr 
625                 630                 635                 640 


Pro Ala Thr Ser Thr Ala Ala Pro Ser Ala Pro Ala Leu Ser Thr Pro 
                645                 650                 655     


Gly Ile Arg Asp Ser Ala Phe Ser Met Glu Ser Ile Asp Asp Tyr Val 
            660                 665                 670         


Asn Val Pro Glu Ser Gly Glu Ser Ala Glu Ala Ser Leu Asp Gly Ser 
        675                 680                 685             


Arg Glu Tyr Val Asn Val Ser Gln Glu Leu His Pro Gly Ala Ala Lys 
    690                 695                 700                 


Thr Glu Pro Ala Ala Leu Ser Ser Gln Glu Ala Glu Glu Val Glu Glu 
705                 710                 715                 720 


Glu Gly Ala Pro Asp Tyr Glu Asn Leu Gln Glu Leu Asn 
                725                 730             


<210>  58
<211>  499
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  CAR Amino Acid Sequence

<400>  58

Met Ala Leu Pro Val Thr Ala Leu Leu Leu Pro Leu Ala Leu Leu Leu 
1               5                   10                  15      


His Ala Ala Arg Pro Asp Ile Val Met Thr Gln Ala Ala Pro Ser Val 
            20                  25                  30          


Pro Val Thr Pro Gly Glu Ser Val Ser Ile Ser Cys Arg Ser Ser Lys 
        35                  40                  45              


Thr Leu Leu His Ser Asn Gly Asn Thr Tyr Leu Tyr Trp Phe Leu Gln 
    50                  55                  60                  


Arg Pro Gly Gln Ser Pro Gln Val Leu Ile Tyr Arg Met Ser Asn Leu 
65                  70                  75                  80  


Ala Ser Gly Val Pro Asn Arg Phe Ser Gly Ser Gly Ser Glu Thr Thr 
                85                  90                  95      


Phe Thr Leu Arg Ile Ser Arg Val Glu Ala Glu Asp Val Gly Ile Tyr 
            100                 105                 110         


Tyr Cys Met Gln His Leu Glu Tyr Pro Tyr Thr Phe Gly Gly Gly Thr 
        115                 120                 125             


Lys Leu Glu Ile Glu Arg Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser 
    130                 135                 140                 


Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser Glu Val Gln Leu Glu Glu 
145                 150                 155                 160 


Ser Gly Ala Glu Leu Val Arg Pro Gly Thr Ser Val Lys Leu Ser Cys 
                165                 170                 175     


Lys Ala Ser Gly Tyr Thr Phe Thr Ser Tyr Trp Met His Trp Ile Lys 
            180                 185                 190         


Gln Arg Pro Glu Gln Gly Leu Glu Trp Ile Gly Arg Ile Asp Pro Tyr 
        195                 200                 205             


Asp Ser Glu Thr His Tyr Asn Glu Lys Phe Lys Asp Lys Ala Ile Leu 
    210                 215                 220                 


Ser Val Asp Lys Ser Ser Ser Thr Ala Tyr Ile Gln Leu Ser Ser Leu 
225                 230                 235                 240 


Thr Ser Asp Asp Ser Ala Val Tyr Tyr Cys Ser Arg Arg Asp Ala Lys 
                245                 250                 255     


Tyr Asp Gly Tyr Ala Leu Asp Tyr Trp Gly Gln Gly Thr Ser Val Thr 
            260                 265                 270         


Val Ser Ser Thr Pro Ala Pro Arg Pro Pro Thr Pro Ala Pro Thr Ile 
        275                 280                 285             


Ala Ser Gln Pro Leu Ser Leu Arg Pro Glu Ala Cys Arg Pro Ala Ala 
    290                 295                 300                 


Gly Gly Ala Val His Thr Arg Gly Leu Asp Phe Ala Cys Asp Phe Trp 
305                 310                 315                 320 


Val Leu Val Val Val Gly Gly Val Leu Ala Cys Tyr Ser Leu Leu Val 
                325                 330                 335     


Thr Val Ala Phe Ile Ile Phe Trp Val Lys Arg Gly Arg Lys Lys Leu 
            340                 345                 350         


Leu Tyr Ile Phe Lys Gln Pro Phe Met Arg Pro Val Gln Thr Thr Gln 
        355                 360                 365             


Glu Glu Asp Gly Cys Ser Cys Arg Phe Pro Glu Glu Glu Glu Gly Gly 
    370                 375                 380                 


Cys Glu Leu Arg Val Lys Phe Ser Arg Ser Ala Asp Ala Pro Ala Tyr 
385                 390                 395                 400 


Lys Gln Gly Gln Asn Gln Leu Tyr Asn Glu Leu Asn Leu Gly Arg Arg 
                405                 410                 415     


Glu Glu Tyr Asp Val Leu Asp Lys Arg Arg Gly Arg Asp Pro Glu Met 
            420                 425                 430         


Gly Gly Lys Pro Arg Arg Lys Asn Pro Gln Glu Gly Leu Tyr Asn Glu 
        435                 440                 445             


Leu Gln Lys Asp Lys Met Ala Glu Ala Tyr Ser Glu Ile Gly Met Lys 
    450                 455                 460                 


Gly Glu Arg Arg Arg Gly Lys Gly His Asp Gly Leu Tyr Gln Gly Leu 
465                 470                 475                 480 


Ser Thr Ala Thr Lys Asp Thr Tyr Asp Ala Leu His Met Gln Ala Leu 
                485                 490                 495     


Pro Pro Arg 
            


<210>  59
<211>  621
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  CAR Amino Acid Sequence

<400>  59

Met Ala Leu Pro Val Thr Ala Leu Leu Leu Pro Leu Ala Leu Leu Leu 
1               5                   10                  15      


His Ala Ala Arg Pro Asp Ile Val Met Thr Gln Ala Ala Pro Ser Val 
            20                  25                  30          


Pro Val Thr Pro Gly Glu Ser Val Ser Ile Ser Cys Arg Ser Ser Lys 
        35                  40                  45              


Thr Leu Leu His Ser Asn Gly Asn Thr Tyr Leu Tyr Trp Phe Leu Gln 
    50                  55                  60                  


Arg Pro Gly Gln Ser Pro Gln Val Leu Ile Tyr Arg Met Ser Asn Leu 
65                  70                  75                  80  


Ala Ser Gly Val Pro Asn Arg Phe Ser Gly Ser Gly Ser Glu Thr Thr 
                85                  90                  95      


Phe Thr Leu Arg Ile Ser Arg Val Glu Ala Glu Asp Val Gly Ile Tyr 
            100                 105                 110         


Tyr Cys Met Gln His Leu Glu Tyr Pro Tyr Thr Phe Gly Gly Gly Thr 
        115                 120                 125             


Lys Leu Glu Ile Glu Arg Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser 
    130                 135                 140                 


Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser Glu Val Gln Leu Glu Glu 
145                 150                 155                 160 


Ser Gly Ala Glu Leu Val Arg Pro Gly Thr Ser Val Lys Leu Ser Cys 
                165                 170                 175     


Lys Ala Ser Gly Tyr Thr Phe Thr Ser Tyr Trp Met His Trp Ile Lys 
            180                 185                 190         


Gln Arg Pro Glu Gln Gly Leu Glu Trp Ile Gly Arg Ile Asp Pro Tyr 
        195                 200                 205             


Asp Ser Glu Thr His Tyr Asn Glu Lys Phe Lys Asp Lys Ala Ile Leu 
    210                 215                 220                 


Ser Val Asp Lys Ser Ser Ser Thr Ala Tyr Ile Gln Leu Ser Ser Leu 
225                 230                 235                 240 


Thr Ser Asp Asp Ser Ala Val Tyr Tyr Cys Ser Arg Arg Asp Ala Lys 
                245                 250                 255     


Tyr Asp Gly Tyr Ala Leu Asp Tyr Trp Gly Gln Gly Thr Ser Val Thr 
            260                 265                 270         


Val Ser Ser Pro Arg Ala Ser Thr Thr Thr Pro Ala Pro Arg Pro Pro 
        275                 280                 285             


Thr Pro Ala Pro Thr Ile Ala Ser Gln Pro Leu Ser Leu Arg Pro Glu 
    290                 295                 300                 


Ala Cys Arg Pro Ala Ala Gly Gly Ala Val His Thr Arg Gly Leu Asp 
305                 310                 315                 320 


Phe Ala Cys Asp Phe Trp Val Leu Val Val Val Gly Gly Val Leu Ala 
                325                 330                 335     


Cys Tyr Ser Leu Leu Val Thr Val Ala Phe Ile Ile Phe Trp Val Lys 
            340                 345                 350         


Arg Gly Arg Lys Lys Leu Leu Tyr Ile Phe Lys Gln Pro Phe Met Arg 
        355                 360                 365             


Pro Val Gln Thr Thr Gln Glu Glu Asp Gly Cys Ser Cys Arg Phe Pro 
    370                 375                 380                 


Glu Glu Glu Glu Gly Gly Cys Glu Leu Lys Arg Lys Lys Gln Arg Ser 
385                 390                 395                 400 


Arg Arg Asn Asp Glu Glu Leu Glu Thr Arg Ala His Arg Val Ala Thr 
                405                 410                 415     


Glu Glu Arg Gly Arg Lys Pro His Gln Ile Pro Ala Ser Thr Pro Gln 
            420                 425                 430         


Asn Pro Ala Thr Ser Gln His Pro Pro Pro Pro Pro Gly His Arg Ser 
        435                 440                 445             


Gln Ala Pro Ser His Arg Pro Pro Pro Pro Gly His Arg Val Gln His 
    450                 455                 460                 


Gln Pro Gln Lys Arg Pro Pro Ala Pro Ser Gly Thr Gln Val His Gln 
465                 470                 475                 480 


Gln Lys Gly Pro Pro Leu Pro Arg Pro Arg Val Gln Pro Lys Pro Pro 
                485                 490                 495     


His Gly Ala Ala Glu Asn Ser Leu Ser Pro Ser Ser Asn Arg Val Lys 
            500                 505                 510         


Phe Ser Arg Ser Ala Asp Ala Pro Ala Tyr Lys Gln Gly Gln Asn Gln 
        515                 520                 525             


Leu Tyr Asn Glu Leu Asn Leu Gly Arg Arg Glu Glu Tyr Asp Val Leu 
    530                 535                 540                 


Asp Lys Arg Arg Gly Arg Asp Pro Glu Met Gly Gly Lys Pro Arg Arg 
545                 550                 555                 560 


Lys Asn Pro Gln Glu Gly Leu Tyr Asn Glu Leu Gln Lys Asp Lys Met 
                565                 570                 575     


Ala Glu Ala Tyr Ser Glu Ile Gly Met Lys Gly Glu Arg Arg Arg Gly 
            580                 585                 590         


Lys Gly His Asp Gly Leu Tyr Gln Gly Leu Ser Thr Ala Thr Lys Asp 
        595                 600                 605             


Thr Tyr Asp Ala Leu His Met Gln Ala Leu Pro Pro Arg 
    610                 615                 620     


<210>  60
<211>  477
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  CAR Amino Acid Sequence

<400>  60

Met Ala Leu Pro Val Thr Ala Leu Leu Leu Pro Leu Ala Leu Leu Leu 
1               5                   10                  15      


His Ala Ala Arg Pro Asp Ile Lys Met Thr Gln Ser Pro Ser Ser Met 
            20                  25                  30          


Tyr Val Ser Leu Gly Glu Arg Val Thr Ile Thr Cys Lys Ala Ser Gln 
        35                  40                  45              


Asp Ile Asn Ser Phe Leu Ser Trp Phe Gln Gln Lys Pro Gly Lys Ser 
    50                  55                  60                  


Pro Lys Thr Leu Ile Tyr Arg Ala Asn Arg Leu Val Asp Gly Val Pro 
65                  70                  75                  80  


Ser Arg Phe Ser Gly Ser Gly Ser Gly Gln Asp Tyr Ser Leu Thr Ile 
                85                  90                  95      


Ser Ser Leu Glu Tyr Glu Asp Met Glu Ile Tyr Tyr Cys Leu Gln Tyr 
            100                 105                 110         


Asp Glu Phe Pro Tyr Thr Phe Gly Gly Gly Thr Lys Leu Glu Met Lys 
        115                 120                 125             


Arg Gly Gly Gly Gly Ser Glu Val Lys Leu Glu Glu Ser Gly Ala Glu 
    130                 135                 140                 


Leu Val Lys Pro Gly Ala Ser Val Lys Leu Ser Cys Arg Thr Ser Gly 
145                 150                 155                 160 


Phe Asn Ile Lys Asp Thr Tyr Ile His Trp Val Lys Gln Arg Pro Glu 
                165                 170                 175     


Gln Gly Leu Lys Trp Ile Gly Arg Ile Asp Pro Ala Asn Gly Asn Thr 
            180                 185                 190         


Lys Tyr Asp Pro Lys Phe Gln Asp Lys Ala Thr Val Thr Ala Asp Thr 
        195                 200                 205             


Ser Ser Asn Thr Ala Tyr Leu Gln Leu Ser Ser Leu Thr Ser Glu Asp 
    210                 215                 220                 


Thr Ala Val Tyr Tyr Cys Val Thr Tyr Ala Tyr Asp Gly Asn Trp Tyr 
225                 230                 235                 240 


Phe Asp Val Trp Gly Ala Gly Thr Ala Val Thr Val Ser Ser Thr Pro 
                245                 250                 255     


Ala Pro Arg Pro Pro Thr Pro Ala Pro Thr Ile Ala Ser Gln Pro Leu 
            260                 265                 270         


Ser Leu Arg Pro Glu Ala Cys Arg Pro Ala Ala Gly Gly Ala Val His 
        275                 280                 285             


Thr Arg Gly Leu Asp Phe Ala Cys Asp Phe Trp Val Leu Val Val Val 
    290                 295                 300                 


Gly Gly Val Leu Ala Cys Tyr Ser Leu Leu Val Thr Val Ala Phe Ile 
305                 310                 315                 320 


Ile Phe Trp Val Arg Ser Lys Arg Ser Arg Leu Leu His Ser Asp Tyr 
                325                 330                 335     


Met Asn Met Thr Pro Arg Arg Pro Gly Pro Thr Arg Lys His Tyr Gln 
            340                 345                 350         


Pro Tyr Ala Pro Pro Arg Asp Phe Ala Ala Tyr Arg Ser Arg Val Lys 
        355                 360                 365             


Phe Ser Arg Ser Ala Asp Ala Pro Ala Tyr Lys Gln Gly Gln Asn Gln 
    370                 375                 380                 


Leu Tyr Asn Glu Leu Asn Leu Gly Arg Arg Glu Glu Tyr Asp Val Leu 
385                 390                 395                 400 


Asp Lys Arg Arg Gly Arg Asp Pro Glu Met Gly Gly Lys Pro Arg Arg 
                405                 410                 415     


Lys Asn Pro Gln Glu Gly Leu Tyr Asn Glu Leu Gln Lys Asp Lys Met 
            420                 425                 430         


Ala Glu Ala Tyr Ser Glu Ile Gly Met Lys Gly Glu Arg Arg Arg Gly 
        435                 440                 445             


Lys Gly His Asp Gly Leu Tyr Gln Gly Leu Ser Thr Ala Thr Lys Asp 
    450                 455                 460                 


Thr Tyr Asp Ala Leu His Met Gln Ala Leu Pro Pro Arg 
465                 470                 475         


<210>  61
<211>  478
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  CAR Amino Acid Sequence

<400>  61

Met Ala Leu Pro Val Thr Ala Leu Leu Leu Pro Leu Ala Leu Leu Leu 
1               5                   10                  15      


His Ala Ala Arg Pro Asp Ile Lys Met Thr Gln Ser Pro Ser Ser Met 
            20                  25                  30          


Tyr Val Ser Leu Gly Glu Arg Val Thr Ile Thr Cys Lys Ala Ser Gln 
        35                  40                  45              


Asp Ile Asn Ser Phe Leu Ser Trp Phe Gln Gln Lys Pro Gly Lys Ser 
    50                  55                  60                  


Pro Lys Thr Leu Ile Tyr Arg Ala Asn Arg Leu Val Asp Gly Val Pro 
65                  70                  75                  80  


Ser Arg Phe Ser Gly Ser Gly Ser Gly Gln Asp Tyr Ser Leu Thr Ile 
                85                  90                  95      


Ser Ser Leu Glu Tyr Glu Asp Met Glu Ile Tyr Tyr Cys Leu Gln Tyr 
            100                 105                 110         


Asp Glu Phe Pro Tyr Thr Phe Gly Gly Gly Thr Lys Leu Glu Met Lys 
        115                 120                 125             


Arg Gly Gly Gly Gly Ser Glu Val Lys Leu Glu Glu Ser Gly Ala Glu 
    130                 135                 140                 


Leu Val Lys Pro Gly Ala Ser Val Lys Leu Ser Cys Arg Thr Ser Gly 
145                 150                 155                 160 


Phe Asn Ile Lys Asp Thr Tyr Ile His Trp Val Lys Gln Arg Pro Glu 
                165                 170                 175     


Gln Gly Leu Lys Trp Ile Gly Arg Ile Asp Pro Ala Asn Gly Asn Thr 
            180                 185                 190         


Lys Tyr Asp Pro Lys Phe Gln Asp Lys Ala Thr Val Thr Ala Asp Thr 
        195                 200                 205             


Ser Ser Asn Thr Ala Tyr Leu Gln Leu Ser Ser Leu Thr Ser Glu Asp 
    210                 215                 220                 


Thr Ala Val Tyr Tyr Cys Val Thr Tyr Ala Tyr Asp Gly Asn Trp Tyr 
225                 230                 235                 240 


Phe Asp Val Trp Gly Ala Gly Thr Ala Val Thr Val Ser Ser Thr Pro 
                245                 250                 255     


Ala Pro Arg Pro Pro Thr Pro Ala Pro Thr Ile Ala Ser Gln Pro Leu 
            260                 265                 270         


Ser Leu Arg Pro Glu Ala Cys Arg Pro Ala Ala Gly Gly Ala Val His 
        275                 280                 285             


Thr Arg Gly Leu Asp Phe Ala Cys Asp Phe Trp Val Leu Val Val Val 
    290                 295                 300                 


Gly Gly Val Leu Ala Cys Tyr Ser Leu Leu Val Thr Val Ala Phe Ile 
305                 310                 315                 320 


Ile Phe Trp Val Lys Arg Gly Arg Lys Lys Leu Leu Tyr Ile Phe Lys 
                325                 330                 335     


Gln Pro Phe Met Arg Pro Val Gln Thr Thr Gln Glu Glu Asp Gly Cys 
            340                 345                 350         


Ser Cys Arg Phe Pro Glu Glu Glu Glu Gly Gly Cys Glu Leu Arg Val 
        355                 360                 365             


Lys Phe Ser Arg Ser Ala Asp Ala Pro Ala Tyr Lys Gln Gly Gln Asn 
    370                 375                 380                 


Gln Leu Tyr Asn Glu Leu Asn Leu Gly Arg Arg Glu Glu Tyr Asp Val 
385                 390                 395                 400 


Leu Asp Lys Arg Arg Gly Arg Asp Pro Glu Met Gly Gly Lys Pro Arg 
                405                 410                 415     


Arg Lys Asn Pro Gln Glu Gly Leu Tyr Asn Glu Leu Gln Lys Asp Lys 
            420                 425                 430         


Met Ala Glu Ala Tyr Ser Glu Ile Gly Met Lys Gly Glu Arg Arg Arg 
        435                 440                 445             


Gly Lys Gly His Asp Gly Leu Tyr Gln Gly Leu Ser Thr Ala Thr Lys 
    450                 455                 460                 


Asp Thr Tyr Asp Ala Leu His Met Gln Ala Leu Pro Pro Arg 
465                 470                 475             


<210>  62
<211>  482
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  CAR Amino Acid Sequence

<400>  62

Met Ala Leu Pro Val Thr Ala Leu Leu Leu Pro Leu Ala Leu Leu Leu 
1               5                   10                  15      


His Ala Ala Arg Pro Asp Ile Lys Met Thr Gln Ser Pro Ser Ser Met 
            20                  25                  30          


Tyr Val Ser Leu Gly Glu Arg Val Thr Ile Thr Cys Lys Ala Ser Gln 
        35                  40                  45              


Asp Ile Asn Ser Phe Leu Ser Trp Phe Gln Gln Lys Pro Gly Lys Ser 
    50                  55                  60                  


Pro Lys Thr Leu Ile Tyr Arg Ala Asn Arg Leu Val Asp Gly Val Pro 
65                  70                  75                  80  


Ser Arg Phe Ser Gly Ser Gly Ser Gly Gln Asp Tyr Ser Leu Thr Ile 
                85                  90                  95      


Ser Ser Leu Glu Tyr Glu Asp Met Glu Ile Tyr Tyr Cys Leu Gln Tyr 
            100                 105                 110         


Asp Glu Phe Pro Tyr Thr Phe Gly Gly Gly Thr Lys Leu Glu Met Lys 
        115                 120                 125             


Arg Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser Glu Val Lys Leu Glu 
    130                 135                 140                 


Glu Ser Gly Ala Glu Leu Val Lys Pro Gly Ala Ser Val Lys Leu Ser 
145                 150                 155                 160 


Cys Arg Thr Ser Gly Phe Asn Ile Lys Asp Thr Tyr Ile His Trp Val 
                165                 170                 175     


Lys Gln Arg Pro Glu Gln Gly Leu Lys Trp Ile Gly Arg Ile Asp Pro 
            180                 185                 190         


Ala Asn Gly Asn Thr Lys Tyr Asp Pro Lys Phe Gln Asp Lys Ala Thr 
        195                 200                 205             


Val Thr Ala Asp Thr Ser Ser Asn Thr Ala Tyr Leu Gln Leu Ser Ser 
    210                 215                 220                 


Leu Thr Ser Glu Asp Thr Ala Val Tyr Tyr Cys Val Thr Tyr Ala Tyr 
225                 230                 235                 240 


Asp Gly Asn Trp Tyr Phe Asp Val Trp Gly Ala Gly Thr Ala Val Thr 
                245                 250                 255     


Val Ser Ser Thr Pro Ala Pro Arg Pro Pro Thr Pro Ala Pro Thr Ile 
            260                 265                 270         


Ala Ser Gln Pro Leu Ser Leu Arg Pro Glu Ala Cys Arg Pro Ala Ala 
        275                 280                 285             


Gly Gly Ala Val His Thr Arg Gly Leu Asp Phe Ala Cys Asp Phe Trp 
    290                 295                 300                 


Val Leu Val Val Val Gly Gly Val Leu Ala Cys Tyr Ser Leu Leu Val 
305                 310                 315                 320 


Thr Val Ala Phe Ile Ile Phe Trp Val Arg Ser Lys Arg Ser Arg Leu 
                325                 330                 335     


Leu His Ser Asp Tyr Met Asn Met Thr Pro Arg Arg Pro Gly Pro Thr 
            340                 345                 350         


Arg Lys His Tyr Gln Pro Tyr Ala Pro Pro Arg Asp Phe Ala Ala Tyr 
        355                 360                 365             


Arg Ser Arg Val Lys Phe Ser Arg Ser Ala Asp Ala Pro Ala Tyr Lys 
    370                 375                 380                 


Gln Gly Gln Asn Gln Leu Tyr Asn Glu Leu Asn Leu Gly Arg Arg Glu 
385                 390                 395                 400 


Glu Tyr Asp Val Leu Asp Lys Arg Arg Gly Arg Asp Pro Glu Met Gly 
                405                 410                 415     


Gly Lys Pro Arg Arg Lys Asn Pro Gln Glu Gly Leu Tyr Asn Glu Leu 
            420                 425                 430         


Gln Lys Asp Lys Met Ala Glu Ala Tyr Ser Glu Ile Gly Met Lys Gly 
        435                 440                 445             


Glu Arg Arg Arg Gly Lys Gly His Asp Gly Leu Tyr Gln Gly Leu Ser 
    450                 455                 460                 


Thr Ala Thr Lys Asp Thr Tyr Asp Ala Leu His Met Gln Ala Leu Pro 
465                 470                 475                 480 


Pro Arg 
        


<210>  63
<211>  483
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  CAR Amino Acid Sequence

<400>  63

Met Ala Leu Pro Val Thr Ala Leu Leu Leu Pro Leu Ala Leu Leu Leu 
1               5                   10                  15      


His Ala Ala Arg Pro Asp Ile Lys Met Thr Gln Ser Pro Ser Ser Met 
            20                  25                  30          


Tyr Val Ser Leu Gly Glu Arg Val Thr Ile Thr Cys Lys Ala Ser Gln 
        35                  40                  45              


Asp Ile Asn Ser Phe Leu Ser Trp Phe Gln Gln Lys Pro Gly Lys Ser 
    50                  55                  60                  


Pro Lys Thr Leu Ile Tyr Arg Ala Asn Arg Leu Val Asp Gly Val Pro 
65                  70                  75                  80  


Ser Arg Phe Ser Gly Ser Gly Ser Gly Gln Asp Tyr Ser Leu Thr Ile 
                85                  90                  95      


Ser Ser Leu Glu Tyr Glu Asp Met Glu Ile Tyr Tyr Cys Leu Gln Tyr 
            100                 105                 110         


Asp Glu Phe Pro Tyr Thr Phe Gly Gly Gly Thr Lys Leu Glu Met Lys 
        115                 120                 125             


Arg Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser Glu Val Lys Leu Glu 
    130                 135                 140                 


Glu Ser Gly Ala Glu Leu Val Lys Pro Gly Ala Ser Val Lys Leu Ser 
145                 150                 155                 160 


Cys Arg Thr Ser Gly Phe Asn Ile Lys Asp Thr Tyr Ile His Trp Val 
                165                 170                 175     


Lys Gln Arg Pro Glu Gln Gly Leu Lys Trp Ile Gly Arg Ile Asp Pro 
            180                 185                 190         


Ala Asn Gly Asn Thr Lys Tyr Asp Pro Lys Phe Gln Asp Lys Ala Thr 
        195                 200                 205             


Val Thr Ala Asp Thr Ser Ser Asn Thr Ala Tyr Leu Gln Leu Ser Ser 
    210                 215                 220                 


Leu Thr Ser Glu Asp Thr Ala Val Tyr Tyr Cys Val Thr Tyr Ala Tyr 
225                 230                 235                 240 


Asp Gly Asn Trp Tyr Phe Asp Val Trp Gly Ala Gly Thr Ala Val Thr 
                245                 250                 255     


Val Ser Ser Thr Pro Ala Pro Arg Pro Pro Thr Pro Ala Pro Thr Ile 
            260                 265                 270         


Ala Ser Gln Pro Leu Ser Leu Arg Pro Glu Ala Cys Arg Pro Ala Ala 
        275                 280                 285             


Gly Gly Ala Val His Thr Arg Gly Leu Asp Phe Ala Cys Asp Phe Trp 
    290                 295                 300                 


Val Leu Val Val Val Gly Gly Val Leu Ala Cys Tyr Ser Leu Leu Val 
305                 310                 315                 320 


Thr Val Ala Phe Ile Ile Phe Trp Val Lys Arg Gly Arg Lys Lys Leu 
                325                 330                 335     


Leu Tyr Ile Phe Lys Gln Pro Phe Met Arg Pro Val Gln Thr Thr Gln 
            340                 345                 350         


Glu Glu Asp Gly Cys Ser Cys Arg Phe Pro Glu Glu Glu Glu Gly Gly 
        355                 360                 365             


Cys Glu Leu Arg Val Lys Phe Ser Arg Ser Ala Asp Ala Pro Ala Tyr 
    370                 375                 380                 


Lys Gln Gly Gln Asn Gln Leu Tyr Asn Glu Leu Asn Leu Gly Arg Arg 
385                 390                 395                 400 


Glu Glu Tyr Asp Val Leu Asp Lys Arg Arg Gly Arg Asp Pro Glu Met 
                405                 410                 415     


Gly Gly Lys Pro Arg Arg Lys Asn Pro Gln Glu Gly Leu Tyr Asn Glu 
            420                 425                 430         


Leu Gln Lys Asp Lys Met Ala Glu Ala Tyr Ser Glu Ile Gly Met Lys 
        435                 440                 445             


Gly Glu Arg Arg Arg Gly Lys Gly His Asp Gly Leu Tyr Gln Gly Leu 
    450                 455                 460                 


Ser Thr Ala Thr Lys Asp Thr Tyr Asp Ala Leu His Met Gln Ala Leu 
465                 470                 475                 480 


Pro Pro Arg 
            


<210>  64
<211>  487
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  CAR Amino Acid Sequence

<400>  64

Met Ala Leu Pro Val Thr Ala Leu Leu Leu Pro Leu Ala Leu Leu Leu 
1               5                   10                  15      


His Ala Ala Arg Pro Asp Ile Lys Met Thr Gln Ser Pro Ser Ser Met 
            20                  25                  30          


Tyr Val Ser Leu Gly Glu Arg Val Thr Ile Thr Cys Lys Ala Ser Gln 
        35                  40                  45              


Asp Ile Asn Ser Phe Leu Ser Trp Phe Gln Gln Lys Pro Gly Lys Ser 
    50                  55                  60                  


Pro Lys Thr Leu Ile Tyr Arg Ala Asn Arg Leu Val Asp Gly Val Pro 
65                  70                  75                  80  


Ser Arg Phe Ser Gly Ser Gly Ser Gly Gln Asp Tyr Ser Leu Thr Ile 
                85                  90                  95      


Ser Ser Leu Glu Tyr Glu Asp Met Glu Ile Tyr Tyr Cys Leu Gln Tyr 
            100                 105                 110         


Asp Glu Phe Pro Tyr Thr Phe Gly Gly Gly Thr Lys Leu Glu Met Lys 
        115                 120                 125             


Arg Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser 
    130                 135                 140                 


Glu Val Lys Leu Glu Glu Ser Gly Ala Glu Leu Val Lys Pro Gly Ala 
145                 150                 155                 160 


Ser Val Lys Leu Ser Cys Arg Thr Ser Gly Phe Asn Ile Lys Asp Thr 
                165                 170                 175     


Tyr Ile His Trp Val Lys Gln Arg Pro Glu Gln Gly Leu Lys Trp Ile 
            180                 185                 190         


Gly Arg Ile Asp Pro Ala Asn Gly Asn Thr Lys Tyr Asp Pro Lys Phe 
        195                 200                 205             


Gln Asp Lys Ala Thr Val Thr Ala Asp Thr Ser Ser Asn Thr Ala Tyr 
    210                 215                 220                 


Leu Gln Leu Ser Ser Leu Thr Ser Glu Asp Thr Ala Val Tyr Tyr Cys 
225                 230                 235                 240 


Val Thr Tyr Ala Tyr Asp Gly Asn Trp Tyr Phe Asp Val Trp Gly Ala 
                245                 250                 255     


Gly Thr Ala Val Thr Val Ser Ser Thr Pro Ala Pro Arg Pro Pro Thr 
            260                 265                 270         


Pro Ala Pro Thr Ile Ala Ser Gln Pro Leu Ser Leu Arg Pro Glu Ala 
        275                 280                 285             


Cys Arg Pro Ala Ala Gly Gly Ala Val His Thr Arg Gly Leu Asp Phe 
    290                 295                 300                 


Ala Cys Asp Phe Trp Val Leu Val Val Val Gly Gly Val Leu Ala Cys 
305                 310                 315                 320 


Tyr Ser Leu Leu Val Thr Val Ala Phe Ile Ile Phe Trp Val Arg Ser 
                325                 330                 335     


Lys Arg Ser Arg Leu Leu His Ser Asp Tyr Met Asn Met Thr Pro Arg 
            340                 345                 350         


Arg Pro Gly Pro Thr Arg Lys His Tyr Gln Pro Tyr Ala Pro Pro Arg 
        355                 360                 365             


Asp Phe Ala Ala Tyr Arg Ser Arg Val Lys Phe Ser Arg Ser Ala Asp 
    370                 375                 380                 


Ala Pro Ala Tyr Lys Gln Gly Gln Asn Gln Leu Tyr Asn Glu Leu Asn 
385                 390                 395                 400 


Leu Gly Arg Arg Glu Glu Tyr Asp Val Leu Asp Lys Arg Arg Gly Arg 
                405                 410                 415     


Asp Pro Glu Met Gly Gly Lys Pro Arg Arg Lys Asn Pro Gln Glu Gly 
            420                 425                 430         


Leu Tyr Asn Glu Leu Gln Lys Asp Lys Met Ala Glu Ala Tyr Ser Glu 
        435                 440                 445             


Ile Gly Met Lys Gly Glu Arg Arg Arg Gly Lys Gly His Asp Gly Leu 
    450                 455                 460                 


Tyr Gln Gly Leu Ser Thr Ala Thr Lys Asp Thr Tyr Asp Ala Leu His 
465                 470                 475                 480 


Met Gln Ala Leu Pro Pro Arg 
                485         


<210>  65
<211>  488
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  CAR Amino Acid Sequence

<400>  65

Met Ala Leu Pro Val Thr Ala Leu Leu Leu Pro Leu Ala Leu Leu Leu 
1               5                   10                  15      


His Ala Ala Arg Pro Asp Ile Lys Met Thr Gln Ser Pro Ser Ser Met 
            20                  25                  30          


Tyr Val Ser Leu Gly Glu Arg Val Thr Ile Thr Cys Lys Ala Ser Gln 
        35                  40                  45              


Asp Ile Asn Ser Phe Leu Ser Trp Phe Gln Gln Lys Pro Gly Lys Ser 
    50                  55                  60                  


Pro Lys Thr Leu Ile Tyr Arg Ala Asn Arg Leu Val Asp Gly Val Pro 
65                  70                  75                  80  


Ser Arg Phe Ser Gly Ser Gly Ser Gly Gln Asp Tyr Ser Leu Thr Ile 
                85                  90                  95      


Ser Ser Leu Glu Tyr Glu Asp Met Glu Ile Tyr Tyr Cys Leu Gln Tyr 
            100                 105                 110         


Asp Glu Phe Pro Tyr Thr Phe Gly Gly Gly Thr Lys Leu Glu Met Lys 
        115                 120                 125             


Arg Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser 
    130                 135                 140                 


Glu Val Lys Leu Glu Glu Ser Gly Ala Glu Leu Val Lys Pro Gly Ala 
145                 150                 155                 160 


Ser Val Lys Leu Ser Cys Arg Thr Ser Gly Phe Asn Ile Lys Asp Thr 
                165                 170                 175     


Tyr Ile His Trp Val Lys Gln Arg Pro Glu Gln Gly Leu Lys Trp Ile 
            180                 185                 190         


Gly Arg Ile Asp Pro Ala Asn Gly Asn Thr Lys Tyr Asp Pro Lys Phe 
        195                 200                 205             


Gln Asp Lys Ala Thr Val Thr Ala Asp Thr Ser Ser Asn Thr Ala Tyr 
    210                 215                 220                 


Leu Gln Leu Ser Ser Leu Thr Ser Glu Asp Thr Ala Val Tyr Tyr Cys 
225                 230                 235                 240 


Val Thr Tyr Ala Tyr Asp Gly Asn Trp Tyr Phe Asp Val Trp Gly Ala 
                245                 250                 255     


Gly Thr Ala Val Thr Val Ser Ser Thr Pro Ala Pro Arg Pro Pro Thr 
            260                 265                 270         


Pro Ala Pro Thr Ile Ala Ser Gln Pro Leu Ser Leu Arg Pro Glu Ala 
        275                 280                 285             


Cys Arg Pro Ala Ala Gly Gly Ala Val His Thr Arg Gly Leu Asp Phe 
    290                 295                 300                 


Ala Cys Asp Phe Trp Val Leu Val Val Val Gly Gly Val Leu Ala Cys 
305                 310                 315                 320 


Tyr Ser Leu Leu Val Thr Val Ala Phe Ile Ile Phe Trp Val Lys Arg 
                325                 330                 335     


Gly Arg Lys Lys Leu Leu Tyr Ile Phe Lys Gln Pro Phe Met Arg Pro 
            340                 345                 350         


Val Gln Thr Thr Gln Glu Glu Asp Gly Cys Ser Cys Arg Phe Pro Glu 
        355                 360                 365             


Glu Glu Glu Gly Gly Cys Glu Leu Arg Val Lys Phe Ser Arg Ser Ala 
    370                 375                 380                 


Asp Ala Pro Ala Tyr Lys Gln Gly Gln Asn Gln Leu Tyr Asn Glu Leu 
385                 390                 395                 400 


Asn Leu Gly Arg Arg Glu Glu Tyr Asp Val Leu Asp Lys Arg Arg Gly 
                405                 410                 415     


Arg Asp Pro Glu Met Gly Gly Lys Pro Arg Arg Lys Asn Pro Gln Glu 
            420                 425                 430         


Gly Leu Tyr Asn Glu Leu Gln Lys Asp Lys Met Ala Glu Ala Tyr Ser 
        435                 440                 445             


Glu Ile Gly Met Lys Gly Glu Arg Arg Arg Gly Lys Gly His Asp Gly 
    450                 455                 460                 


Leu Tyr Gln Gly Leu Ser Thr Ala Thr Lys Asp Thr Tyr Asp Ala Leu 
465                 470                 475                 480 


His Met Gln Ala Leu Pro Pro Arg 
                485             


<210>  66
<211>  492
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  CAR Amino Acid Sequence

<400>  66

Met Ala Leu Pro Val Thr Ala Leu Leu Leu Pro Leu Ala Leu Leu Leu 
1               5                   10                  15      


His Ala Ala Arg Pro Asp Ile Lys Met Thr Gln Ser Pro Ser Ser Met 
            20                  25                  30          


Tyr Val Ser Leu Gly Glu Arg Val Thr Ile Thr Cys Lys Ala Ser Gln 
        35                  40                  45              


Asp Ile Asn Ser Phe Leu Ser Trp Phe Gln Gln Lys Pro Gly Lys Ser 
    50                  55                  60                  


Pro Lys Thr Leu Ile Tyr Arg Ala Asn Arg Leu Val Asp Gly Val Pro 
65                  70                  75                  80  


Ser Arg Phe Ser Gly Ser Gly Ser Gly Gln Asp Tyr Ser Leu Thr Ile 
                85                  90                  95      


Ser Ser Leu Glu Tyr Glu Asp Met Glu Ile Tyr Tyr Cys Leu Gln Tyr 
            100                 105                 110         


Asp Glu Phe Pro Tyr Thr Phe Gly Gly Gly Thr Lys Leu Glu Met Lys 
        115                 120                 125             


Arg Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser 
    130                 135                 140                 


Gly Gly Gly Gly Ser Glu Val Lys Leu Glu Glu Ser Gly Ala Glu Leu 
145                 150                 155                 160 


Val Lys Pro Gly Ala Ser Val Lys Leu Ser Cys Arg Thr Ser Gly Phe 
                165                 170                 175     


Asn Ile Lys Asp Thr Tyr Ile His Trp Val Lys Gln Arg Pro Glu Gln 
            180                 185                 190         


Gly Leu Lys Trp Ile Gly Arg Ile Asp Pro Ala Asn Gly Asn Thr Lys 
        195                 200                 205             


Tyr Asp Pro Lys Phe Gln Asp Lys Ala Thr Val Thr Ala Asp Thr Ser 
    210                 215                 220                 


Ser Asn Thr Ala Tyr Leu Gln Leu Ser Ser Leu Thr Ser Glu Asp Thr 
225                 230                 235                 240 


Ala Val Tyr Tyr Cys Val Thr Tyr Ala Tyr Asp Gly Asn Trp Tyr Phe 
                245                 250                 255     


Asp Val Trp Gly Ala Gly Thr Ala Val Thr Val Ser Ser Thr Pro Ala 
            260                 265                 270         


Pro Arg Pro Pro Thr Pro Ala Pro Thr Ile Ala Ser Gln Pro Leu Ser 
        275                 280                 285             


Leu Arg Pro Glu Ala Cys Arg Pro Ala Ala Gly Gly Ala Val His Thr 
    290                 295                 300                 


Arg Gly Leu Asp Phe Ala Cys Asp Phe Trp Val Leu Val Val Val Gly 
305                 310                 315                 320 


Gly Val Leu Ala Cys Tyr Ser Leu Leu Val Thr Val Ala Phe Ile Ile 
                325                 330                 335     


Phe Trp Val Arg Ser Lys Arg Ser Arg Leu Leu His Ser Asp Tyr Met 
            340                 345                 350         


Asn Met Thr Pro Arg Arg Pro Gly Pro Thr Arg Lys His Tyr Gln Pro 
        355                 360                 365             


Tyr Ala Pro Pro Arg Asp Phe Ala Ala Tyr Arg Ser Arg Val Lys Phe 
    370                 375                 380                 


Ser Arg Ser Ala Asp Ala Pro Ala Tyr Lys Gln Gly Gln Asn Gln Leu 
385                 390                 395                 400 


Tyr Asn Glu Leu Asn Leu Gly Arg Arg Glu Glu Tyr Asp Val Leu Asp 
                405                 410                 415     


Lys Arg Arg Gly Arg Asp Pro Glu Met Gly Gly Lys Pro Arg Arg Lys 
            420                 425                 430         


Asn Pro Gln Glu Gly Leu Tyr Asn Glu Leu Gln Lys Asp Lys Met Ala 
        435                 440                 445             


Glu Ala Tyr Ser Glu Ile Gly Met Lys Gly Glu Arg Arg Arg Gly Lys 
    450                 455                 460                 


Gly His Asp Gly Leu Tyr Gln Gly Leu Ser Thr Ala Thr Lys Asp Thr 
465                 470                 475                 480 


Tyr Asp Ala Leu His Met Gln Ala Leu Pro Pro Arg 
                485                 490         


<210>  67
<211>  493
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  CAR Amino Acid Sequence

<400>  67

Met Ala Leu Pro Val Thr Ala Leu Leu Leu Pro Leu Ala Leu Leu Leu 
1               5                   10                  15      


His Ala Ala Arg Pro Asp Ile Lys Met Thr Gln Ser Pro Ser Ser Met 
            20                  25                  30          


Tyr Val Ser Leu Gly Glu Arg Val Thr Ile Thr Cys Lys Ala Ser Gln 
        35                  40                  45              


Asp Ile Asn Ser Phe Leu Ser Trp Phe Gln Gln Lys Pro Gly Lys Ser 
    50                  55                  60                  


Pro Lys Thr Leu Ile Tyr Arg Ala Asn Arg Leu Val Asp Gly Val Pro 
65                  70                  75                  80  


Ser Arg Phe Ser Gly Ser Gly Ser Gly Gln Asp Tyr Ser Leu Thr Ile 
                85                  90                  95      


Ser Ser Leu Glu Tyr Glu Asp Met Glu Ile Tyr Tyr Cys Leu Gln Tyr 
            100                 105                 110         


Asp Glu Phe Pro Tyr Thr Phe Gly Gly Gly Thr Lys Leu Glu Met Lys 
        115                 120                 125             


Arg Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser 
    130                 135                 140                 


Gly Gly Gly Gly Ser Glu Val Lys Leu Glu Glu Ser Gly Ala Glu Leu 
145                 150                 155                 160 


Val Lys Pro Gly Ala Ser Val Lys Leu Ser Cys Arg Thr Ser Gly Phe 
                165                 170                 175     


Asn Ile Lys Asp Thr Tyr Ile His Trp Val Lys Gln Arg Pro Glu Gln 
            180                 185                 190         


Gly Leu Lys Trp Ile Gly Arg Ile Asp Pro Ala Asn Gly Asn Thr Lys 
        195                 200                 205             


Tyr Asp Pro Lys Phe Gln Asp Lys Ala Thr Val Thr Ala Asp Thr Ser 
    210                 215                 220                 


Ser Asn Thr Ala Tyr Leu Gln Leu Ser Ser Leu Thr Ser Glu Asp Thr 
225                 230                 235                 240 


Ala Val Tyr Tyr Cys Val Thr Tyr Ala Tyr Asp Gly Asn Trp Tyr Phe 
                245                 250                 255     


Asp Val Trp Gly Ala Gly Thr Ala Val Thr Val Ser Ser Thr Pro Ala 
            260                 265                 270         


Pro Arg Pro Pro Thr Pro Ala Pro Thr Ile Ala Ser Gln Pro Leu Ser 
        275                 280                 285             


Leu Arg Pro Glu Ala Cys Arg Pro Ala Ala Gly Gly Ala Val His Thr 
    290                 295                 300                 


Arg Gly Leu Asp Phe Ala Cys Asp Phe Trp Val Leu Val Val Val Gly 
305                 310                 315                 320 


Gly Val Leu Ala Cys Tyr Ser Leu Leu Val Thr Val Ala Phe Ile Ile 
                325                 330                 335     


Phe Trp Val Lys Arg Gly Arg Lys Lys Leu Leu Tyr Ile Phe Lys Gln 
            340                 345                 350         


Pro Phe Met Arg Pro Val Gln Thr Thr Gln Glu Glu Asp Gly Cys Ser 
        355                 360                 365             


Cys Arg Phe Pro Glu Glu Glu Glu Gly Gly Cys Glu Leu Arg Val Lys 
    370                 375                 380                 


Phe Ser Arg Ser Ala Asp Ala Pro Ala Tyr Lys Gln Gly Gln Asn Gln 
385                 390                 395                 400 


Leu Tyr Asn Glu Leu Asn Leu Gly Arg Arg Glu Glu Tyr Asp Val Leu 
                405                 410                 415     


Asp Lys Arg Arg Gly Arg Asp Pro Glu Met Gly Gly Lys Pro Arg Arg 
            420                 425                 430         


Lys Asn Pro Gln Glu Gly Leu Tyr Asn Glu Leu Gln Lys Asp Lys Met 
        435                 440                 445             


Ala Glu Ala Tyr Ser Glu Ile Gly Met Lys Gly Glu Arg Arg Arg Gly 
    450                 455                 460                 


Lys Gly His Asp Gly Leu Tyr Gln Gly Leu Ser Thr Ala Thr Lys Asp 
465                 470                 475                 480 


Thr Tyr Asp Ala Leu His Met Gln Ala Leu Pro Pro Arg 
                485                 490             


<210>  68
<211>  608
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  CAR Amino Acid Sequence

<400>  68

Met Ala Leu Pro Val Thr Ala Leu Leu Leu Pro Leu Ala Leu Leu Leu 
1               5                   10                  15      


His Ala Ala Arg Pro Asp Ile Lys Met Thr Gln Ser Pro Ser Ser Met 
            20                  25                  30          


Tyr Val Ser Leu Gly Glu Arg Val Thr Ile Thr Cys Lys Ala Ser Gln 
        35                  40                  45              


Asp Ile Asn Ser Phe Leu Ser Trp Phe Gln Gln Lys Pro Gly Lys Ser 
    50                  55                  60                  


Pro Lys Thr Leu Ile Tyr Arg Ala Asn Arg Leu Val Asp Gly Val Pro 
65                  70                  75                  80  


Ser Arg Phe Ser Gly Ser Gly Ser Gly Gln Asp Tyr Ser Leu Thr Ile 
                85                  90                  95      


Ser Ser Leu Glu Tyr Glu Asp Met Glu Ile Tyr Tyr Cys Leu Gln Tyr 
            100                 105                 110         


Asp Glu Phe Pro Tyr Thr Phe Gly Gly Gly Thr Lys Leu Glu Met Lys 
        115                 120                 125             


Arg Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser 
    130                 135                 140                 


Gly Gly Gly Gly Ser Glu Val Lys Leu Glu Glu Ser Gly Ala Glu Leu 
145                 150                 155                 160 


Val Lys Pro Gly Ala Ser Val Lys Leu Ser Cys Arg Thr Ser Gly Phe 
                165                 170                 175     


Asn Ile Lys Asp Thr Tyr Ile His Trp Val Lys Gln Arg Pro Glu Gln 
            180                 185                 190         


Gly Leu Lys Trp Ile Gly Arg Ile Asp Pro Ala Asn Gly Asn Thr Lys 
        195                 200                 205             


Tyr Asp Pro Lys Phe Gln Asp Lys Ala Thr Val Thr Ala Asp Thr Ser 
    210                 215                 220                 


Ser Asn Thr Ala Tyr Leu Gln Leu Ser Ser Leu Thr Ser Glu Asp Thr 
225                 230                 235                 240 


Ala Val Tyr Tyr Cys Val Thr Tyr Ala Tyr Asp Gly Asn Trp Tyr Phe 
                245                 250                 255     


Asp Val Trp Gly Ala Gly Thr Ala Val Thr Val Ser Ser Thr Pro Ala 
            260                 265                 270         


Pro Arg Pro Pro Thr Pro Ala Pro Thr Ile Ala Ser Gln Pro Leu Ser 
        275                 280                 285             


Leu Arg Pro Glu Ala Cys Arg Pro Ala Ala Gly Gly Ala Val His Thr 
    290                 295                 300                 


Arg Gly Leu Asp Phe Ala Cys Asp Phe Trp Val Leu Val Val Val Gly 
305                 310                 315                 320 


Gly Val Leu Ala Cys Tyr Ser Leu Leu Val Thr Val Ala Phe Ile Ile 
                325                 330                 335     


Phe Trp Val Arg Ser Lys Arg Ser Arg Leu Leu His Ser Asp Tyr Met 
            340                 345                 350         


Asn Met Thr Pro Arg Arg Pro Gly Pro Thr Arg Lys His Tyr Gln Pro 
        355                 360                 365             


Tyr Ala Pro Pro Arg Asp Phe Ala Ala Tyr Arg Ser Lys Arg Lys Lys 
    370                 375                 380                 


Gln Arg Ser Arg Arg Asn Asp Glu Glu Leu Glu Thr Arg Ala His Arg 
385                 390                 395                 400 


Val Ala Thr Glu Glu Arg Gly Arg Lys Pro His Gln Ile Pro Ala Ser 
                405                 410                 415     


Thr Pro Gln Asn Pro Ala Thr Ser Gln His Pro Pro Pro Pro Pro Gly 
            420                 425                 430         


His Arg Ser Gln Ala Pro Ser His Arg Pro Pro Pro Pro Gly His Arg 
        435                 440                 445             


Val Gln His Gln Pro Gln Lys Arg Pro Pro Ala Pro Ser Gly Thr Gln 
    450                 455                 460                 


Val His Gln Gln Lys Gly Pro Pro Leu Pro Arg Pro Arg Val Gln Pro 
465                 470                 475                 480 


Lys Pro Pro His Gly Ala Ala Glu Asn Ser Leu Ser Pro Ser Ser Asn 
                485                 490                 495     


Arg Val Lys Phe Ser Arg Ser Ala Asp Ala Pro Ala Tyr Lys Gln Gly 
            500                 505                 510         


Gln Asn Gln Leu Tyr Asn Glu Leu Asn Leu Gly Arg Arg Glu Glu Tyr 
        515                 520                 525             


Asp Val Leu Asp Lys Arg Arg Gly Arg Asp Pro Glu Met Gly Gly Lys 
    530                 535                 540                 


Pro Arg Arg Lys Asn Pro Gln Glu Gly Leu Tyr Asn Glu Leu Gln Lys 
545                 550                 555                 560 


Asp Lys Met Ala Glu Ala Tyr Ser Glu Ile Gly Met Lys Gly Glu Arg 
                565                 570                 575     


Arg Arg Gly Lys Gly His Asp Gly Leu Tyr Gln Gly Leu Ser Thr Ala 
            580                 585                 590         


Thr Lys Asp Thr Tyr Asp Ala Leu His Met Gln Ala Leu Pro Pro Arg 
        595                 600                 605             


<210>  69
<211>  89
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  CD132

<400>  69

Phe Trp Leu Glu Arg Thr Met Pro Arg Ile Pro Thr Leu Lys Asn Leu 
1               5                   10                  15      


Glu Asp Leu Val Thr Glu Tyr His Gly Asn Phe Ser Ala Trp Ser Gly 
            20                  25                  30          


Val Ser Lys Gly Leu Ala Glu Ser Leu Gln Pro Asp Tyr Ser Glu Arg 
        35                  40                  45              


Leu Cys Leu Val Ser Glu Ile Pro Pro Lys Gly Gly Ala Leu Gly Glu 
    50                  55                  60                  


Gly Pro Gly Ala Ser Pro Cys Asn Gln His Ser Pro Tyr Trp Ala Pro 
65                  70                  75                  80  


Pro Cys Tyr Thr Leu Lys Pro Glu Thr 
                85                  


<210>  70
<211>  593
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  CAR containing CD132 C' to CD3 zeta

<400>  70

Met Ala Leu Pro Val Thr Ala Leu Leu Leu Pro Leu Ala Leu Leu Leu 
1               5                   10                  15      


His Ala Ala Arg Pro Asp Ile Val Met Thr Gln Ala Ala Pro Ser Val 
            20                  25                  30          


Pro Val Thr Pro Gly Glu Ser Val Ser Ile Ser Cys Arg Ser Ser Lys 
        35                  40                  45              


Thr Leu Leu His Ser Asn Gly Asn Thr Tyr Leu Tyr Trp Phe Leu Gln 
    50                  55                  60                  


Arg Pro Gly Gln Ser Pro Gln Val Leu Ile Tyr Arg Met Ser Asn Leu 
65                  70                  75                  80  


Ala Ser Gly Val Pro Asn Arg Phe Ser Gly Ser Gly Ser Glu Thr Thr 
                85                  90                  95      


Phe Thr Leu Arg Ile Ser Arg Val Glu Ala Glu Asp Val Gly Ile Tyr 
            100                 105                 110         


Tyr Cys Met Gln His Leu Glu Tyr Pro Tyr Thr Phe Gly Gly Gly Thr 
        115                 120                 125             


Lys Leu Glu Ile Glu Arg Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser 
    130                 135                 140                 


Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser Glu Val Gln Leu Glu Glu 
145                 150                 155                 160 


Ser Gly Ala Glu Leu Val Arg Pro Gly Thr Ser Val Lys Leu Ser Cys 
                165                 170                 175     


Lys Ala Ser Gly Tyr Thr Phe Thr Ser Tyr Trp Met His Trp Ile Lys 
            180                 185                 190         


Gln Arg Pro Glu Gln Gly Leu Glu Trp Ile Gly Arg Ile Asp Pro Tyr 
        195                 200                 205             


Asp Ser Glu Thr His Tyr Asn Glu Lys Phe Lys Asp Lys Ala Ile Leu 
    210                 215                 220                 


Ser Val Asp Lys Ser Ser Ser Thr Ala Tyr Ile Gln Leu Ser Ser Leu 
225                 230                 235                 240 


Thr Ser Asp Asp Ser Ala Val Tyr Tyr Cys Ser Arg Arg Asp Ala Lys 
                245                 250                 255     


Tyr Asp Gly Tyr Ala Leu Asp Tyr Trp Gly Gln Gly Thr Ser Val Thr 
            260                 265                 270         


Val Ser Ser Pro Arg Ala Ser Thr Thr Thr Pro Ala Pro Arg Pro Pro 
        275                 280                 285             


Thr Pro Ala Pro Thr Ile Ala Ser Gln Pro Leu Ser Leu Arg Pro Glu 
    290                 295                 300                 


Ala Cys Arg Pro Ala Ala Gly Gly Ala Val His Thr Arg Gly Leu Asp 
305                 310                 315                 320 


Phe Ala Cys Asp Phe Trp Val Leu Val Val Val Gly Gly Val Leu Ala 
                325                 330                 335     


Cys Tyr Ser Leu Leu Val Thr Val Ala Phe Ile Ile Phe Trp Val Arg 
            340                 345                 350         


Ser Lys Arg Ser Arg Leu Leu His Ser Asp Tyr Met Asn Met Thr Pro 
        355                 360                 365             


Arg Arg Pro Gly Pro Thr Arg Lys His Tyr Gln Pro Tyr Ala Pro Pro 
    370                 375                 380                 


Arg Asp Phe Ala Ala Tyr Arg Ser Arg Val Lys Phe Ser Arg Ser Ala 
385                 390                 395                 400 


Asp Ala Pro Ala Tyr Lys Gln Gly Gln Asn Gln Leu Tyr Asn Glu Leu 
                405                 410                 415     


Asn Leu Gly Arg Arg Glu Glu Tyr Asp Val Leu Asp Lys Arg Arg Gly 
            420                 425                 430         


Arg Asp Pro Glu Met Gly Gly Lys Pro Arg Arg Lys Asn Pro Gln Glu 
        435                 440                 445             


Gly Leu Tyr Asn Glu Leu Gln Lys Asp Lys Met Ala Glu Ala Tyr Ser 
    450                 455                 460                 


Glu Ile Gly Met Lys Gly Glu Arg Arg Arg Gly Lys Gly His Asp Gly 
465                 470                 475                 480 


Leu Tyr Gln Gly Leu Ser Thr Ala Thr Lys Asp Thr Tyr Asp Ala Leu 
                485                 490                 495     


His Met Gln Ala Leu Pro Pro Arg Phe Trp Leu Glu Arg Thr Met Pro 
            500                 505                 510         


Arg Ile Pro Thr Leu Lys Asn Leu Glu Asp Leu Val Thr Glu Tyr His 
        515                 520                 525             


Gly Asn Phe Ser Ala Trp Ser Gly Val Ser Lys Gly Leu Ala Glu Ser 
    530                 535                 540                 


Leu Gln Pro Asp Tyr Ser Glu Arg Leu Cys Leu Val Ser Glu Ile Pro 
545                 550                 555                 560 


Pro Lys Gly Gly Ala Leu Gly Glu Gly Pro Gly Ala Ser Pro Cys Asn 
                565                 570                 575     


Gln His Ser Pro Tyr Trp Ala Pro Pro Cys Tyr Thr Leu Lys Pro Glu 
            580                 585                 590         


Thr 
    


<210>  71
<211>  108
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  CD2 gRNA


<220>
<221>  misc_feature
<222>  (1)..(1)
<223>  2'OMe

<220>
<221>  misc_feature
<222>  (3)..(3)
<223>  phosphorothioate

<220>
<221>  misc_feature
<222>  (5)..(5)
<223>  phosphorothioate

<220>
<221>  misc_feature
<222>  (7)..(7)
<223>  phosphorothioate

<220>
<221>  misc_feature
<222>  (101)..(101)
<223>  2'OMe

<220>
<221>  misc_feature
<222>  (103)..(103)
<223>  phosphorothioate

<220>
<221>  misc_feature
<222>  (105)..(105)
<223>  phosphorothioate

<220>
<221>  misc_feature
<222>  (107)..(107)
<223>  phosphorothioate

<400>  71
nancnangcu gacaggcucg acacguuuua gagcuagaaa uagcaaguua aaauaaggcu       60

aguccguuau caacuugaaa aaguggcacc gagucggugc nunununu                   108


<210>  72
<211>  108
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  TRAC gRNA


<220>
<221>  misc_feature
<222>  (1)..(1)
<223>  2'OMe

<220>
<221>  misc_feature
<222>  (3)..(3)
<223>  phosphorothioate

<220>
<221>  misc_feature
<222>  (5)..(5)
<223>  phosphorothioate

<220>
<221>  misc_feature
<222>  (7)..(7)
<223>  phosphorothioate

<220>
<221>  misc_feature
<222>  (101)..(101)
<223>  2'OMe

<220>
<221>  misc_feature
<222>  (103)..(103)
<223>  phosphorothioate

<220>
<221>  misc_feature
<222>  (105)..(105)
<223>  phosphorothioate

<220>
<221>  misc_feature
<222>  (107)..(107)
<223>  phosphorothioate

<400>  72
ngnangnaau caaaaucggu gaauguuuua gagcuagaaa uagcaaguua aaauaaggcu       60

aguccguuau caacuugaaa aaguggcacc gagucggugc nunununu                   108


<210>  73
<211>  22
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  PCR Primer (CD2)  (F, forward)

<400>  73
accaaagatc tcctggactt gt                                                22


<210>  74
<211>  20
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  PCR Primer (CD2)  (R, reverse)

<400>  74
gcatgcctct gcctactgag                                                   20


<210>  75
<211>  19
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  PCR Primer (TRAC)  (F, forward)

<400>  75
ggggcaaaga gggaaatga                                                    19


<210>  76
<211>  21
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  PCR Primer (TRAC)  (R, reverse)

<400>  76
gtcagatttg ttgctccagg c                                                 21


