                         SEQUENCE LISTING

<110>  ACADEMIA SINICA
       WONG, CHI-HUEY
       WU, CHUNG-YI
       MA, CHE
       FAN, CHEN-YU
 
<120>  MESSENGER RNA VACCINES AGAINST WIDE SPECTRUM OF CORONAVIRUS 
       VARIANTS

<130>  G4590-15000PCT

<150>  US 63/173,752
<151>  2021-04-12

<150>  US 63/264,737
<151>  2021-12-01

<160>  52    

<170>  PatentIn version 3.5

<210>  1
<211>  3822
<212>  DNA
<213>  SARS-CoV-2 (Wuhan strain)

<400>  1
atgttcgtct tcctggtcct gctgcctctg gtctcctcac agtgcgtcaa tctgacaact       60

cggactcagc tgccacctgc ttatactaat agcttcacca gaggcgtgta ctatcctgac      120

aaggtgttta gaagctccgt gctgcactct acacaggatc tgtttctgcc attctttagc      180

aacgtgacct ggttccacgc catccacgtg agcggcacca atggcacaaa gcggttcgac      240

aatcccgtgc tgccttttaa cgatggcgtg tacttcgcct ctaccgagaa gagcaacatc      300

atcagaggct ggatctttgg caccacactg gactccaaga cacagtctct gctgatcgtg      360

aacaatgcca ccaacgtggt catcaaggtg tgcgagttcc agttttgtaa tgatcccttc      420

ctgggcgtgt actatcacaa gaacaataag agctggatgg agtccgagtt tagagtgtat      480

tctagcgcca acaactgcac atttgagtac gtgagccagc ctttcctgat ggacctggag      540

ggcaagcagg gcaatttcaa gaacctgagg gagttcgtgt ttaagaatat cgacggctac      600

ttcaaaatct actctaagca cacccccatc aacctggtgc gcgacctgcc tcagggcttc      660

agcgccctgg agcccctggt ggatctgcct atcggcatca acatcacccg gtttcagaca      720

ctgctggccc tgcacagaag ctacctgaca cccggcgact cctctagcgg atggaccgcc      780

ggcgctgccg cctactatgt gggctacctc cagccccgga ccttcctgct gaagtacaac      840

gagaatggca ccatcacaga cgcagtggat tgcgccctgg accccctgag cgagacaaag      900

tgtacactga agtcctttac cgtggagaag ggcatctatc agacatccaa tttcagggtg      960

cagccaaccg agtctatcgt gcgctttcct aatatcacaa acctgtgccc atttggcgag     1020

gtgttcaacg caacccgctt cgccagcgtg tacgcctgga ataggaagcg gatcagcaac     1080

tgcgtggccg actatagcgt gctgtacaac tccgcctctt tcagcacctt taagtgctat     1140

ggcgtgtccc ccacaaagct gaatgacctg tgctttacca acgtctacgc cgattctttc     1200

gtgatcaggg gcgacgaggt gcgccagatc gcccccggcc agacaggcaa gatcgcagac     1260

tacaattata agctgccaga cgatttcacc ggctgcgtga tcgcctggaa cagcaacaat     1320

ctggattcca aagtgggcgg caactacaat tatctgtacc ggctgtttag aaagagcaat     1380

ctgaagccct tcgagaggga catctctaca gaaatctacc aggccggcag caccccttgc     1440

aatggcgtgg agggctttaa ctgttatttc ccactccagt cctacggctt ccagcccaca     1500

aacggcgtgg gctatcagcc ttaccgcgtg gtggtgctga gctttgagct gctgcacgcc     1560

ccagcaacag tgtgcggccc caagaagtcc accaatctgg tgaagaacaa gtgcgtgaac     1620

ttcaacttca acggcctgac cggcacaggc gtgctgaccg agtccaacaa gaagttcctg     1680

ccatttcagc agttcggcag ggacatcgca gataccacag acgccgtgcg cgacccacag     1740

accctggaga tcctggacat cacaccctgc tctttcggcg gcgtgagcgt gatcacaccc     1800

ggcaccaata caagcaacca ggtggccgtg ctgtatcagg acgtgaattg taccgaggtg     1860

cccgtggcta tccacgccga tcagctgacc ccaacatggc gggtgtacag caccggctcc     1920

aacgtcttcc agacaagagc cggatgcctg atcggagcag agcacgtgaa caattcctat     1980

gagtgcgaca tcccaatcgg cgccggcatc tgtgcctctt accagaccca gacaaactct     2040

cccagaagag cccggagcgt ggcctcccag tctatcatcg cctataccat gtccctgggc     2100

gccgagaaca gcgtggccta ctctaacaat agcatcgcca tcccaaccaa cttcacaatc     2160

tctgtgacca cagagatcct gcccgtgtcc atgaccaaga catctgtgga ctgcacaatg     2220

tatatctgtg gcgattctac cgagtgcagc aacctgctgc tccagtacgg cagcttttgt     2280

acccagctga atagagccct gacaggcatc gccgtggagc aggataagaa cacacaggag     2340

gtgttcgccc aggtgaagca aatctacaag acccccccta tcaaggactt tggcggcttc     2400

aatttttccc agatcctgcc tgatccatcc aagccttcta agcggagctt tatcgaggac     2460

ctgctgttca acaaggtgac cctggccgat gccggcttca tcaagcagta tggcgattgc     2520

ctgggcgaca tcgcagccag ggacctgatc tgcgcccaga agtttaatgg cctgaccgtg     2580

ctgccacccc tgctgacaga tgagatgatc gcacagtaca caagcgccct gctggccggc     2640

accatcacat ccggatggac cttcggcgca ggagccgccc tccagatccc ctttgccatg     2700

cagatggcct ataggttcaa cggcatcggc gtgacccaga atgtgctgta cgagaaccag     2760

aagctgatcg ccaatcagtt taactccgcc atcggcaaga tccaggacag cctgtcctct     2820

acagccagcg ccctgggcaa gctccaggat gtggtgaatc agaacgccca ggccctgaat     2880

accctggtga agcagctgag cagcaacttc ggcgccatct ctagcgtgct gaatgacatc     2940

ctgagccggc tggacaaggt ggaggcagag gtgcagatcg accggctgat caccggccgg     3000

ctccagagcc tccagaccta tgtgacacag cagctgatca gggccgccga gatcagggcc     3060

agcgccaatc tggcagcaac caagatgtcc gagtgcgtgc tgggccagtc taagagagtg     3120

gacttttgtg gcaagggcta tcacctgatg tccttccctc agtctgcccc acacggcgtg     3180

gtgtttctgc acgtgaccta cgtgcccgcc caggagaaga acttcaccac agcccctgcc     3240

atctgccacg atggcaaggc ccactttcca agggagggcg tgttcgtgtc caacggcacc     3300

cactggtttg tgacacagcg caatttctac gagccccaga tcatcaccac agacaacacc     3360

ttcgtgagcg gcaactgtga cgtggtcatc ggcatcgtga acaataccgt gtatgatcca     3420

ctccagcccg agctggacag ctttaaggag gagctggata agtatttcaa gaatcacacc     3480

tcccctgacg tggatctggg cgacatcagc ggcatcaatg cctccgtggt gaacatccag     3540

aaggagatcg accgcctgaa cgaggtggct aagaatctga acgagagcct gatcgacctc     3600

caggagctgg gcaagtatga gcagtacatc aagtggccct ggtacatctg gctgggcttc     3660

atcgccggcc tgatcgccat cgtgatggtg accatcatgc tgtgctgtat gacatcctgc     3720

tgttcttgcc tgaagggctg ctgtagctgt ggctcctgct gtaagtttga cgaggatgac     3780

tctgaacctg tgctgaaggg cgtgaagctg cattacacct aa                        3822


<210>  2
<211>  1273
<212>  PRT
<213>  SARS-CoV-2 (Wuhan strain)

<400>  2

Met Phe Val Phe Leu Val Leu Leu Pro Leu Val Ser Ser Gln Cys Val 
1               5                   10                  15      


Asn Leu Thr Thr Arg Thr Gln Leu Pro Pro Ala Tyr Thr Asn Ser Phe 
            20                  25                  30          


Thr Arg Gly Val Tyr Tyr Pro Asp Lys Val Phe Arg Ser Ser Val Leu 
        35                  40                  45              


His Ser Thr Gln Asp Leu Phe Leu Pro Phe Phe Ser Asn Val Thr Trp 
    50                  55                  60                  


Phe His Ala Ile His Val Ser Gly Thr Asn Gly Thr Lys Arg Phe Asp 
65                  70                  75                  80  


Asn Pro Val Leu Pro Phe Asn Asp Gly Val Tyr Phe Ala Ser Thr Glu 
                85                  90                  95      


Lys Ser Asn Ile Ile Arg Gly Trp Ile Phe Gly Thr Thr Leu Asp Ser 
            100                 105                 110         


Lys Thr Gln Ser Leu Leu Ile Val Asn Asn Ala Thr Asn Val Val Ile 
        115                 120                 125             


Lys Val Cys Glu Phe Gln Phe Cys Asn Asp Pro Phe Leu Gly Val Tyr 
    130                 135                 140                 


Tyr His Lys Asn Asn Lys Ser Trp Met Glu Ser Glu Phe Arg Val Tyr 
145                 150                 155                 160 


Ser Ser Ala Asn Asn Cys Thr Phe Glu Tyr Val Ser Gln Pro Phe Leu 
                165                 170                 175     


Met Asp Leu Glu Gly Lys Gln Gly Asn Phe Lys Asn Leu Arg Glu Phe 
            180                 185                 190         


Val Phe Lys Asn Ile Asp Gly Tyr Phe Lys Ile Tyr Ser Lys His Thr 
        195                 200                 205             


Pro Ile Asn Leu Val Arg Asp Leu Pro Gln Gly Phe Ser Ala Leu Glu 
    210                 215                 220                 


Pro Leu Val Asp Leu Pro Ile Gly Ile Asn Ile Thr Arg Phe Gln Thr 
225                 230                 235                 240 


Leu Leu Ala Leu His Arg Ser Tyr Leu Thr Pro Gly Asp Ser Ser Ser 
                245                 250                 255     


Gly Trp Thr Ala Gly Ala Ala Ala Tyr Tyr Val Gly Tyr Leu Gln Pro 
            260                 265                 270         


Arg Thr Phe Leu Leu Lys Tyr Asn Glu Asn Gly Thr Ile Thr Asp Ala 
        275                 280                 285             


Val Asp Cys Ala Leu Asp Pro Leu Ser Glu Thr Lys Cys Thr Leu Lys 
    290                 295                 300                 


Ser Phe Thr Val Glu Lys Gly Ile Tyr Gln Thr Ser Asn Phe Arg Val 
305                 310                 315                 320 


Gln Pro Thr Glu Ser Ile Val Arg Phe Pro Asn Ile Thr Asn Leu Cys 
                325                 330                 335     


Pro Phe Gly Glu Val Phe Asn Ala Thr Arg Phe Ala Ser Val Tyr Ala 
            340                 345                 350         


Trp Asn Arg Lys Arg Ile Ser Asn Cys Val Ala Asp Tyr Ser Val Leu 
        355                 360                 365             


Tyr Asn Ser Ala Ser Phe Ser Thr Phe Lys Cys Tyr Gly Val Ser Pro 
    370                 375                 380                 


Thr Lys Leu Asn Asp Leu Cys Phe Thr Asn Val Tyr Ala Asp Ser Phe 
385                 390                 395                 400 


Val Ile Arg Gly Asp Glu Val Arg Gln Ile Ala Pro Gly Gln Thr Gly 
                405                 410                 415     


Lys Ile Ala Asp Tyr Asn Tyr Lys Leu Pro Asp Asp Phe Thr Gly Cys 
            420                 425                 430         


Val Ile Ala Trp Asn Ser Asn Asn Leu Asp Ser Lys Val Gly Gly Asn 
        435                 440                 445             


Tyr Asn Tyr Leu Tyr Arg Leu Phe Arg Lys Ser Asn Leu Lys Pro Phe 
    450                 455                 460                 


Glu Arg Asp Ile Ser Thr Glu Ile Tyr Gln Ala Gly Ser Thr Pro Cys 
465                 470                 475                 480 


Asn Gly Val Glu Gly Phe Asn Cys Tyr Phe Pro Leu Gln Ser Tyr Gly 
                485                 490                 495     


Phe Gln Pro Thr Asn Gly Val Gly Tyr Gln Pro Tyr Arg Val Val Val 
            500                 505                 510         


Leu Ser Phe Glu Leu Leu His Ala Pro Ala Thr Val Cys Gly Pro Lys 
        515                 520                 525             


Lys Ser Thr Asn Leu Val Lys Asn Lys Cys Val Asn Phe Asn Phe Asn 
    530                 535                 540                 


Gly Leu Thr Gly Thr Gly Val Leu Thr Glu Ser Asn Lys Lys Phe Leu 
545                 550                 555                 560 


Pro Phe Gln Gln Phe Gly Arg Asp Ile Ala Asp Thr Thr Asp Ala Val 
                565                 570                 575     


Arg Asp Pro Gln Thr Leu Glu Ile Leu Asp Ile Thr Pro Cys Ser Phe 
            580                 585                 590         


Gly Gly Val Ser Val Ile Thr Pro Gly Thr Asn Thr Ser Asn Gln Val 
        595                 600                 605             


Ala Val Leu Tyr Gln Asp Val Asn Cys Thr Glu Val Pro Val Ala Ile 
    610                 615                 620                 


His Ala Asp Gln Leu Thr Pro Thr Trp Arg Val Tyr Ser Thr Gly Ser 
625                 630                 635                 640 


Asn Val Phe Gln Thr Arg Ala Gly Cys Leu Ile Gly Ala Glu His Val 
                645                 650                 655     


Asn Asn Ser Tyr Glu Cys Asp Ile Pro Ile Gly Ala Gly Ile Cys Ala 
            660                 665                 670         


Ser Tyr Gln Thr Gln Thr Asn Ser Pro Arg Arg Ala Arg Ser Val Ala 
        675                 680                 685             


Ser Gln Ser Ile Ile Ala Tyr Thr Met Ser Leu Gly Ala Glu Asn Ser 
    690                 695                 700                 


Val Ala Tyr Ser Asn Asn Ser Ile Ala Ile Pro Thr Asn Phe Thr Ile 
705                 710                 715                 720 


Ser Val Thr Thr Glu Ile Leu Pro Val Ser Met Thr Lys Thr Ser Val 
                725                 730                 735     


Asp Cys Thr Met Tyr Ile Cys Gly Asp Ser Thr Glu Cys Ser Asn Leu 
            740                 745                 750         


Leu Leu Gln Tyr Gly Ser Phe Cys Thr Gln Leu Asn Arg Ala Leu Thr 
        755                 760                 765             


Gly Ile Ala Val Glu Gln Asp Lys Asn Thr Gln Glu Val Phe Ala Gln 
    770                 775                 780                 


Val Lys Gln Ile Tyr Lys Thr Pro Pro Ile Lys Asp Phe Gly Gly Phe 
785                 790                 795                 800 


Asn Phe Ser Gln Ile Leu Pro Asp Pro Ser Lys Pro Ser Lys Arg Ser 
                805                 810                 815     


Phe Ile Glu Asp Leu Leu Phe Asn Lys Val Thr Leu Ala Asp Ala Gly 
            820                 825                 830         


Phe Ile Lys Gln Tyr Gly Asp Cys Leu Gly Asp Ile Ala Ala Arg Asp 
        835                 840                 845             


Leu Ile Cys Ala Gln Lys Phe Asn Gly Leu Thr Val Leu Pro Pro Leu 
    850                 855                 860                 


Leu Thr Asp Glu Met Ile Ala Gln Tyr Thr Ser Ala Leu Leu Ala Gly 
865                 870                 875                 880 


Thr Ile Thr Ser Gly Trp Thr Phe Gly Ala Gly Ala Ala Leu Gln Ile 
                885                 890                 895     


Pro Phe Ala Met Gln Met Ala Tyr Arg Phe Asn Gly Ile Gly Val Thr 
            900                 905                 910         


Gln Asn Val Leu Tyr Glu Asn Gln Lys Leu Ile Ala Asn Gln Phe Asn 
        915                 920                 925             


Ser Ala Ile Gly Lys Ile Gln Asp Ser Leu Ser Ser Thr Ala Ser Ala 
    930                 935                 940                 


Leu Gly Lys Leu Gln Asp Val Val Asn Gln Asn Ala Gln Ala Leu Asn 
945                 950                 955                 960 


Thr Leu Val Lys Gln Leu Ser Ser Asn Phe Gly Ala Ile Ser Ser Val 
                965                 970                 975     


Leu Asn Asp Ile Leu Ser Arg Leu Asp Pro Pro Glu Ala Glu Val Gln 
            980                 985                 990         


Ile Asp Arg Leu Ile Thr Gly Arg  Leu Gln Ser Leu Gln  Thr Tyr Val 
        995                 1000                 1005             


Thr Gln  Gln Leu Ile Arg Ala  Ala Glu Ile Arg Ala  Ser Ala Asn 
    1010                 1015                 1020             


Leu Ala  Ala Thr Lys Met Ser  Glu Cys Val Leu Gly  Gln Ser Lys 
    1025                 1030                 1035             


Arg Val  Asp Phe Cys Gly Lys  Gly Tyr His Leu Met  Ser Phe Pro 
    1040                 1045                 1050             


Gln Ser  Ala Pro His Gly Val  Val Phe Leu His Val  Thr Tyr Val 
    1055                 1060                 1065             


Pro Ala  Gln Glu Lys Asn Phe  Thr Thr Ala Pro Ala  Ile Cys His 
    1070                 1075                 1080             


Asp Gly  Lys Ala His Phe Pro  Arg Glu Gly Val Phe  Val Ser Asn 
    1085                 1090                 1095             


Gly Thr  His Trp Phe Val Thr  Gln Arg Asn Phe Tyr  Glu Pro Gln 
    1100                 1105                 1110             


Ile Ile  Thr Thr Asp Asn Thr  Phe Val Ser Gly Asn  Cys Asp Val 
    1115                 1120                 1125             


Val Ile  Gly Ile Val Asn Asn  Thr Val Tyr Asp Pro  Leu Gln Pro 
    1130                 1135                 1140             


Glu Leu  Asp Ser Phe Lys Glu  Glu Leu Asp Lys Tyr  Phe Lys Asn 
    1145                 1150                 1155             


His Thr  Ser Pro Asp Val Asp  Leu Gly Asp Ile Ser  Gly Ile Asn 
    1160                 1165                 1170             


Ala Ser  Val Val Asn Ile Gln  Lys Glu Ile Asp Arg  Leu Asn Glu 
    1175                 1180                 1185             


Val Ala  Lys Asn Leu Asn Glu  Ser Leu Ile Asp Leu  Gln Glu Leu 
    1190                 1195                 1200             


Gly Lys  Tyr Glu Gln Tyr Ile  Lys Trp Pro Trp Tyr  Ile Trp Leu 
    1205                 1210                 1215             


Gly Phe  Ile Ala Gly Leu Ile  Ala Ile Val Met Val  Thr Ile Met 
    1220                 1225                 1230             


Leu Cys  Cys Met Thr Ser Cys  Cys Ser Cys Leu Lys  Gly Cys Cys 
    1235                 1240                 1245             


Ser Cys  Gly Ser Cys Cys Lys  Phe Asp Glu Asp Asp  Ser Glu Pro 
    1250                 1255                 1260             


Val Leu  Lys Gly Val Lys Leu  His Tyr Thr 
    1265                 1270             


<210>  3
<211>  3822
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  S-(deg-RBD)

<400>  3
atgttcgtct tcctggtcct gctgcctctg gtctcctcac agtgcgtcaa tctgacaact       60

cggactcagc tgccacctgc ttatactaat agcttcacca gaggcgtgta ctatcctgac      120

aaggtgttta gaagctccgt gctgcactct acacaggatc tgtttctgcc attctttagc      180

aacgtgacct ggttccacgc catccacgtg agcggcacca atggcacaaa gcggttcgac      240

aatcccgtgc tgccttttaa cgatggcgtg tacttcgcct ctaccgagaa gagcaacatc      300

atcagaggct ggatctttgg caccacactg gactccaaga cacagtctct gctgatcgtg      360

aacaatgcca ccaacgtggt catcaaggtg tgcgagttcc agttttgtaa tgatcccttc      420

ctgggcgtgt actatcacaa gaacaataag agctggatgg agtccgagtt tagagtgtat      480

tctagcgcca acaactgcac atttgagtac gtgagccagc ctttcctgat ggacctggag      540

ggcaagcagg gcaatttcaa gaacctgagg gagttcgtgt ttaagaatat cgacggctac      600

ttcaaaatct actctaagca cacccccatc aacctggtgc gcgacctgcc tcagggcttc      660

agcgccctgg agcccctggt ggatctgcct atcggcatca acatcacccg gtttcagaca      720

ctgctggccc tgcacagaag ctacctgaca cccggcgact cctctagcgg atggaccgcc      780

ggcgctgccg cctactatgt gggctacctc cagccccgga ccttcctgct gaagtacaac      840

gagaatggca ccatcacaga cgcagtggat tgcgccctgg accccctgag cgagacaaag      900

tgtacactga agtcctttac cgtggagaag ggcatctatc agacatccaa tttcagggtg      960

cagccagccg aggcgatcgt gcgctttcct gaaatcacaa acctgtgccc atttggcgag     1020

gtgttcgagg caacccgctt cgccagcgtg tacgcctgga ataggaagcg gatcagcaac     1080

tgcgtggccg actatagcgt gctgtacaac tccgcctctt tcagcacctt taagtgctat     1140

ggcgtgtccc ccacaaagct gaatgacctg tgctttacca acgtctacgc cgattctttc     1200

gtgatcaggg gcgacgaggt gcgccagatc gcccccggcc agacaggcaa gatcgcagac     1260

tacaattata agctgccaga cgatttcacc ggctgcgtga tcgcctggaa cagcaacaat     1320

ctggattcca aagtgggcgg caactacaat tatctgtacc ggctgtttag aaagagcaat     1380

ctgaagccct tcgagaggga catctctaca gaaatctacc aggccggcag caccccttgc     1440

aatggcgtgg agggctttaa ctgttatttc ccactccagt cctacggctt ccagcccaca     1500

aacggcgtgg gctatcagcc ttaccgcgtg gtggtgctga gctttgagct gctgcacgcc     1560

ccagcaacag tgtgcggccc caagaagtcc accaatctgg tgaagaacaa gtgcgtgaac     1620

ttcaacttca acggcctgac cggcacaggc gtgctgaccg agtccaacaa gaagttcctg     1680

ccatttcagc agttcggcag ggacatcgca gataccacag acgccgtgcg cgacccacag     1740

accctggaga tcctggacat cacaccctgc tctttcggcg gcgtgagcgt gatcacaccc     1800

ggcaccaata caagcaacca ggtggccgtg ctgtatcagg acgtgaattg taccgaggtg     1860

cccgtggcta tccacgccga tcagctgacc ccaacatggc gggtgtacag caccggctcc     1920

aacgtcttcc agacaagagc cggatgcctg atcggagcag agcacgtgaa caattcctat     1980

gagtgcgaca tcccaatcgg cgccggcatc tgtgcctctt accagaccca gacaaactct     2040

cccagaagag cccggagcgt ggcctcccag tctatcatcg cctataccat gtccctgggc     2100

gccgagaaca gcgtggccta ctctaacaat agcatcgcca tcccaaccaa cttcacaatc     2160

tctgtgacca cagagatcct gcccgtgtcc atgaccaaga catctgtgga ctgcacaatg     2220

tatatctgtg gcgattctac cgagtgcagc aacctgctgc tccagtacgg cagcttttgt     2280

acccagctga atagagccct gacaggcatc gccgtggagc aggataagaa cacacaggag     2340

gtgttcgccc aggtgaagca aatctacaag acccccccta tcaaggactt tggcggcttc     2400

aatttttccc agatcctgcc tgatccatcc aagccttcta agcggagctt tatcgaggac     2460

ctgctgttca acaaggtgac cctggccgat gccggcttca tcaagcagta tggcgattgc     2520

ctgggcgaca tcgcagccag ggacctgatc tgcgcccaga agtttaatgg cctgaccgtg     2580

ctgccacccc tgctgacaga tgagatgatc gcacagtaca caagcgccct gctggccggc     2640

accatcacat ccggatggac cttcggcgca ggagccgccc tccagatccc ctttgccatg     2700

cagatggcct ataggttcaa cggcatcggc gtgacccaga atgtgctgta cgagaaccag     2760

aagctgatcg ccaatcagtt taactccgcc atcggcaaga tccaggacag cctgtcctct     2820

acagccagcg ccctgggcaa gctccaggat gtggtgaatc agaacgccca ggccctgaat     2880

accctggtga agcagctgag cagcaacttc ggcgccatct ctagcgtgct gaatgacatc     2940

ctgagccggc tggacaaggt ggaggcagag gtgcagatcg accggctgat caccggccgg     3000

ctccagagcc tccagaccta tgtgacacag cagctgatca gggccgccga gatcagggcc     3060

agcgccaatc tggcagcaac caagatgtcc gagtgcgtgc tgggccagtc taagagagtg     3120

gacttttgtg gcaagggcta tcacctgatg tccttccctc agtctgcccc acacggcgtg     3180

gtgtttctgc acgtgaccta cgtgcccgcc caggagaaga acttcaccac agcccctgcc     3240

atctgccacg atggcaaggc ccactttcca agggagggcg tgttcgtgtc caacggcacc     3300

cactggtttg tgacacagcg caatttctac gagccccaga tcatcaccac agacaacacc     3360

ttcgtgagcg gcaactgtga cgtggtcatc ggcatcgtga acaataccgt gtatgatcca     3420

ctccagcccg agctggacag ctttaaggag gagctggata agtatttcaa gaatcacacc     3480

tcccctgacg tggatctggg cgacatcagc ggcatcaatg cctccgtggt gaacatccag     3540

aaggagatcg accgcctgaa cgaggtggct aagaatctga acgagagcct gatcgacctc     3600

caggagctgg gcaagtatga gcagtacatc aagtggccct ggtacatctg gctgggcttc     3660

atcgccggcc tgatcgccat cgtgatggtg accatcatgc tgtgctgtat gacatcctgc     3720

tgttcttgcc tgaagggctg ctgtagctgt ggctcctgct gtaagtttga cgaggatgac     3780

tctgaacctg tgctgaaggg cgtgaagctg cattacacct aa                        3822


<210>  4
<211>  1273
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  S-(deg-RBD)

<400>  4

Met Phe Val Phe Leu Val Leu Leu Pro Leu Val Ser Ser Gln Cys Val 
1               5                   10                  15      


Asn Leu Thr Thr Arg Thr Gln Leu Pro Pro Ala Tyr Thr Asn Ser Phe 
            20                  25                  30          


Thr Arg Gly Val Tyr Tyr Pro Asp Lys Val Phe Arg Ser Ser Val Leu 
        35                  40                  45              


His Ser Thr Gln Asp Leu Phe Leu Pro Phe Phe Ser Asn Val Thr Trp 
    50                  55                  60                  


Phe His Ala Ile His Val Ser Gly Thr Asn Gly Thr Lys Arg Phe Asp 
65                  70                  75                  80  


Asn Pro Val Leu Pro Phe Asn Asp Gly Val Tyr Phe Ala Ser Thr Glu 
                85                  90                  95      


Lys Ser Asn Ile Ile Arg Gly Trp Ile Phe Gly Thr Thr Leu Asp Ser 
            100                 105                 110         


Lys Thr Gln Ser Leu Leu Ile Val Asn Asn Ala Thr Asn Val Val Ile 
        115                 120                 125             


Lys Val Cys Glu Phe Gln Phe Cys Asn Asp Pro Phe Leu Gly Val Tyr 
    130                 135                 140                 


Tyr His Lys Asn Asn Lys Ser Trp Met Glu Ser Glu Phe Arg Val Tyr 
145                 150                 155                 160 


Ser Ser Ala Asn Asn Cys Thr Phe Glu Tyr Val Ser Gln Pro Phe Leu 
                165                 170                 175     


Met Asp Leu Glu Gly Lys Gln Gly Asn Phe Lys Asn Leu Arg Glu Phe 
            180                 185                 190         


Val Phe Lys Asn Ile Asp Gly Tyr Phe Lys Ile Tyr Ser Lys His Thr 
        195                 200                 205             


Pro Ile Asn Leu Val Arg Asp Leu Pro Gln Gly Phe Ser Ala Leu Glu 
    210                 215                 220                 


Pro Leu Val Asp Leu Pro Ile Gly Ile Asn Ile Thr Arg Phe Gln Thr 
225                 230                 235                 240 


Leu Leu Ala Leu His Arg Ser Tyr Leu Thr Pro Gly Asp Ser Ser Ser 
                245                 250                 255     


Gly Trp Thr Ala Gly Ala Ala Ala Tyr Tyr Val Gly Tyr Leu Gln Pro 
            260                 265                 270         


Arg Thr Phe Leu Leu Lys Tyr Asn Glu Asn Gly Thr Ile Thr Asp Ala 
        275                 280                 285             


Val Asp Cys Ala Leu Asp Pro Leu Ser Glu Thr Lys Cys Thr Leu Lys 
    290                 295                 300                 


Ser Phe Thr Val Glu Lys Gly Ile Tyr Gln Thr Ser Asn Phe Arg Val 
305                 310                 315                 320 


Gln Pro Ala Glu Ala Ile Val Arg Phe Pro Gln Ile Thr Asn Leu Cys 
                325                 330                 335     


Pro Phe Gly Glu Val Phe Gln Ala Thr Arg Phe Ala Ser Val Tyr Ala 
            340                 345                 350         


Trp Asn Arg Lys Arg Ile Ser Asn Cys Val Ala Asp Tyr Ser Val Leu 
        355                 360                 365             


Tyr Asn Ser Ala Ser Phe Ser Thr Phe Lys Cys Tyr Gly Val Ser Pro 
    370                 375                 380                 


Thr Lys Leu Asn Asp Leu Cys Phe Thr Asn Val Tyr Ala Asp Ser Phe 
385                 390                 395                 400 


Val Ile Arg Gly Asp Glu Val Arg Gln Ile Ala Pro Gly Gln Thr Gly 
                405                 410                 415     


Lys Ile Ala Asp Tyr Asn Tyr Lys Leu Pro Asp Asp Phe Thr Gly Cys 
            420                 425                 430         


Val Ile Ala Trp Asn Ser Asn Asn Leu Asp Ser Lys Val Gly Gly Asn 
        435                 440                 445             


Tyr Asn Tyr Leu Tyr Arg Leu Phe Arg Lys Ser Asn Leu Lys Pro Phe 
    450                 455                 460                 


Glu Arg Asp Ile Ser Thr Glu Ile Tyr Gln Ala Gly Ser Thr Pro Cys 
465                 470                 475                 480 


Asn Gly Val Glu Gly Phe Asn Cys Tyr Phe Pro Leu Gln Ser Tyr Gly 
                485                 490                 495     


Phe Gln Pro Thr Asn Gly Val Gly Tyr Gln Pro Tyr Arg Val Val Val 
            500                 505                 510         


Leu Ser Phe Glu Leu Leu His Ala Pro Ala Thr Val Cys Gly Pro Lys 
        515                 520                 525             


Lys Ser Thr Asn Leu Val Lys Asn Lys Cys Val Asn Phe Asn Phe Asn 
    530                 535                 540                 


Gly Leu Thr Gly Thr Gly Val Leu Thr Glu Ser Asn Lys Lys Phe Leu 
545                 550                 555                 560 


Pro Phe Gln Gln Phe Gly Arg Asp Ile Ala Asp Thr Thr Asp Ala Val 
                565                 570                 575     


Arg Asp Pro Gln Thr Leu Glu Ile Leu Asp Ile Thr Pro Cys Ser Phe 
            580                 585                 590         


Gly Gly Val Ser Val Ile Thr Pro Gly Thr Asn Thr Ser Asn Gln Val 
        595                 600                 605             


Ala Val Leu Tyr Gln Asp Val Asn Cys Thr Glu Val Pro Val Ala Ile 
    610                 615                 620                 


His Ala Asp Gln Leu Thr Pro Thr Trp Arg Val Tyr Ser Thr Gly Ser 
625                 630                 635                 640 


Asn Val Phe Gln Thr Arg Ala Gly Cys Leu Ile Gly Ala Glu His Val 
                645                 650                 655     


Asn Asn Ser Tyr Glu Cys Asp Ile Pro Ile Gly Ala Gly Ile Cys Ala 
            660                 665                 670         


Ser Tyr Gln Thr Gln Thr Asn Ser Pro Arg Arg Ala Arg Ser Val Ala 
        675                 680                 685             


Ser Gln Ser Ile Ile Ala Tyr Thr Met Ser Leu Gly Ala Glu Asn Ser 
    690                 695                 700                 


Val Ala Tyr Ser Asn Asn Ser Ile Ala Ile Pro Thr Asn Phe Thr Ile 
705                 710                 715                 720 


Ser Val Thr Thr Glu Ile Leu Pro Val Ser Met Thr Lys Thr Ser Val 
                725                 730                 735     


Asp Cys Thr Met Tyr Ile Cys Gly Asp Ser Thr Glu Cys Ser Asn Leu 
            740                 745                 750         


Leu Leu Gln Tyr Gly Ser Phe Cys Thr Gln Leu Asn Arg Ala Leu Thr 
        755                 760                 765             


Gly Ile Ala Val Glu Gln Asp Lys Asn Thr Gln Glu Val Phe Ala Gln 
    770                 775                 780                 


Val Lys Gln Ile Tyr Lys Thr Pro Pro Ile Lys Asp Phe Gly Gly Phe 
785                 790                 795                 800 


Asn Phe Ser Gln Ile Leu Pro Asp Pro Ser Lys Pro Ser Lys Arg Ser 
                805                 810                 815     


Phe Ile Glu Asp Leu Leu Phe Asn Lys Val Thr Leu Ala Asp Ala Gly 
            820                 825                 830         


Phe Ile Lys Gln Tyr Gly Asp Cys Leu Gly Asp Ile Ala Ala Arg Asp 
        835                 840                 845             


Leu Ile Cys Ala Gln Lys Phe Asn Gly Leu Thr Val Leu Pro Pro Leu 
    850                 855                 860                 


Leu Thr Asp Glu Met Ile Ala Gln Tyr Thr Ser Ala Leu Leu Ala Gly 
865                 870                 875                 880 


Thr Ile Thr Ser Gly Trp Thr Phe Gly Ala Gly Ala Ala Leu Gln Ile 
                885                 890                 895     


Pro Phe Ala Met Gln Met Ala Tyr Arg Phe Asn Gly Ile Gly Val Thr 
            900                 905                 910         


Gln Asn Val Leu Tyr Glu Asn Gln Lys Leu Ile Ala Asn Gln Phe Asn 
        915                 920                 925             


Ser Ala Ile Gly Lys Ile Gln Asp Ser Leu Ser Ser Thr Ala Ser Ala 
    930                 935                 940                 


Leu Gly Lys Leu Gln Asp Val Val Asn Gln Asn Ala Gln Ala Leu Asn 
945                 950                 955                 960 


Thr Leu Val Lys Gln Leu Ser Ser Asn Phe Gly Ala Ile Ser Ser Val 
                965                 970                 975     


Leu Asn Asp Ile Leu Ser Arg Leu Asp Pro Pro Glu Ala Glu Val Gln 
            980                 985                 990         


Ile Asp Arg Leu Ile Thr Gly Arg  Leu Gln Ser Leu Gln  Thr Tyr Val 
        995                 1000                 1005             


Thr Gln  Gln Leu Ile Arg Ala  Ala Glu Ile Arg Ala  Ser Ala Asn 
    1010                 1015                 1020             


Leu Ala  Ala Thr Lys Met Ser  Glu Cys Val Leu Gly  Gln Ser Lys 
    1025                 1030                 1035             


Arg Val  Asp Phe Cys Gly Lys  Gly Tyr His Leu Met  Ser Phe Pro 
    1040                 1045                 1050             


Gln Ser  Ala Pro His Gly Val  Val Phe Leu His Val  Thr Tyr Val 
    1055                 1060                 1065             


Pro Ala  Gln Glu Lys Asn Phe  Thr Thr Ala Pro Ala  Ile Cys His 
    1070                 1075                 1080             


Asp Gly  Lys Ala His Phe Pro  Arg Glu Gly Val Phe  Val Ser Asn 
    1085                 1090                 1095             


Gly Thr  His Trp Phe Val Thr  Gln Arg Asn Phe Tyr  Glu Pro Gln 
    1100                 1105                 1110             


Ile Ile  Thr Thr Asp Asn Thr  Phe Val Ser Gly Asn  Cys Asp Val 
    1115                 1120                 1125             


Val Ile  Gly Ile Val Asn Asn  Thr Val Tyr Asp Pro  Leu Gln Pro 
    1130                 1135                 1140             


Glu Leu  Asp Ser Phe Lys Glu  Glu Leu Asp Lys Tyr  Phe Lys Asn 
    1145                 1150                 1155             


His Thr  Ser Pro Asp Val Asp  Leu Gly Asp Ile Ser  Gly Ile Asn 
    1160                 1165                 1170             


Ala Ser  Val Val Asn Ile Gln  Lys Glu Ile Asp Arg  Leu Asn Glu 
    1175                 1180                 1185             


Val Ala  Lys Asn Leu Asn Glu  Ser Leu Ile Asp Leu  Gln Glu Leu 
    1190                 1195                 1200             


Gly Lys  Tyr Glu Gln Tyr Ile  Lys Trp Pro Trp Tyr  Ile Trp Leu 
    1205                 1210                 1215             


Gly Phe  Ile Ala Gly Leu Ile  Ala Ile Val Met Val  Thr Ile Met 
    1220                 1225                 1230             


Leu Cys  Cys Met Thr Ser Cys  Cys Ser Cys Leu Lys  Gly Cys Cys 
    1235                 1240                 1245             


Ser Cys  Gly Ser Cys Cys Lys  Phe Asp Glu Asp Asp  Ser Glu Pro 
    1250                 1255                 1260             


Val Leu  Lys Gly Val Lys Leu  His Tyr Thr 
    1265                 1270             


<210>  5
<211>  3822
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  S-(deg-S2)

<400>  5
atgttcgtct tcctggtcct gctgcctctg gtctcctcac agtgcgtcaa tctgacaact       60

cggactcagc tgccacctgc ttatactaat agcttcacca gaggcgtgta ctatcctgac      120

aaggtgttta gaagctccgt gctgcactct acacaggatc tgtttctgcc attctttagc      180

aacgtgacct ggttccacgc catccacgtg agcggcacca atggcacaaa gcggttcgac      240

aatcccgtgc tgccttttaa cgatggcgtg tacttcgcct ctaccgagaa gagcaacatc      300

atcagaggct ggatctttgg caccacactg gactccaaga cacagtctct gctgatcgtg      360

aacaatgcca ccaacgtggt catcaaggtg tgcgagttcc agttttgtaa tgatcccttc      420

ctgggcgtgt actatcacaa gaacaataag agctggatgg agtccgagtt tagagtgtat      480

tctagcgcca acaactgcac atttgagtac gtgagccagc ctttcctgat ggacctggag      540

ggcaagcagg gcaatttcaa gaacctgagg gagttcgtgt ttaagaatat cgacggctac      600

ttcaaaatct actctaagca cacccccatc aacctggtgc gcgacctgcc tcagggcttc      660

agcgccctgg agcccctggt ggatctgcct atcggcatca acatcacccg gtttcagaca      720

ctgctggccc tgcacagaag ctacctgaca cccggcgact cctctagcgg atggaccgcc      780

ggcgctgccg cctactatgt gggctacctc cagccccgga ccttcctgct gaagtacaac      840

gagaatggca ccatcacaga cgcagtggat tgcgccctgg accccctgag cgagacaaag      900

tgtacactga agtcctttac cgtggagaag ggcatctatc agacatccaa tttcagggtg      960

cagccaaccg agtctatcgt gcgctttcct aatatcacaa acctgtgccc atttggcgag     1020

gtgttcaacg caacccgctt cgccagcgtg tacgcctgga ataggaagcg gatcagcaac     1080

tgcgtggccg actatagcgt gctgtacaac tccgcctctt tcagcacctt taagtgctat     1140

ggcgtgtccc ccacaaagct gaatgacctg tgctttacca acgtctacgc cgattctttc     1200

gtgatcaggg gcgacgaggt gcgccagatc gcccccggcc agacaggcaa gatcgcagac     1260

tacaattata agctgccaga cgatttcacc ggctgcgtga tcgcctggaa cagcaacaat     1320

ctggattcca aagtgggcgg caactacaat tatctgtacc ggctgtttag aaagagcaat     1380

ctgaagccct tcgagaggga catctctaca gaaatctacc aggccggcag caccccttgc     1440

aatggcgtgg agggctttaa ctgttatttc ccactccagt cctacggctt ccagcccaca     1500

aacggcgtgg gctatcagcc ttaccgcgtg gtggtgctga gctttgagct gctgcacgcc     1560

ccagcaacag tgtgcggccc caagaagtcc accaatctgg tgaagaacaa gtgcgtgaac     1620

ttcaacttca acggcctgac cggcacaggc gtgctgaccg agtccaacaa gaagttcctg     1680

ccatttcagc agttcggcag ggacatcgca gataccacag acgccgtgcg cgacccacag     1740

accctggaga tcctggacat cacaccctgc tctttcggcg gcgtgagcgt gatcacaccc     1800

ggcaccaata caagcaacca ggtggccgtg ctgtatcagg acgtgaattg taccgaggtg     1860

cccgtggcta tccacgccga tcagctgacc ccaacatggc gggtgtacag caccggctcc     1920

aacgtcttcc agacaagagc cggatgcctg atcggagcag agcacgtgaa caattcctat     1980

gagtgcgaca tcccaatcgg cgccggcatc tgtgcctctt accagaccca gacaaactct     2040

cccagaagag cccggagcgt ggcctcccag tctatcatcg cctataccat gtccctgggc     2100

gccgagaaca gcgtggccta ctctcagaat agcatcgcca tcccaaccca gttcacaatc     2160

tctgtgacca cagagatcct gcccgtgtcc atgaccaaga catctgtgga ctgcacaatg     2220

tatatctgtg gcgattctac cgagtgcagc aacctgctgc tccagtacgg cagcttttgt     2280

acccagctga atagagccct gacaggcatc gccgtggagc aggataagaa cacacaggag     2340

gtgttcgccc aggtgaagca aatctacaag acccccccta tcaaggactt tggcggcttc     2400

caattttccc agatcctgcc tgatccatcc aagccttcta agcggagctt tatcgaggac     2460

ctgctgttca acaaggtgac cctggccgat gccggcttca tcaagcagta tggcgattgc     2520

ctgggcgaca tcgcagccag ggacctgatc tgcgcccaga agtttaatgg cctgaccgtg     2580

ctgccacccc tgctgacaga tgagatgatc gcacagtaca caagcgccct gctggccggc     2640

accatcacat ccggatggac cttcggcgca ggagccgccc tccagatccc ctttgccatg     2700

cagatggcct ataggttcaa cggcatcggc gtgacccaga atgtgctgta cgagaaccag     2760

aagctgatcg ccaatcagtt taactccgcc atcggcaaga tccaggacag cctgtcctct     2820

acagccagcg ccctgggcaa gctccaggat gtggtgaatc agaacgccca ggccctgaat     2880

accctggtga agcagctgag cagcaacttc ggcgccatct ctagcgtgct gaatgacatc     2940

ctgagccggc tggacaaggt ggaggcagag gtgcagatcg accggctgat caccggccgg     3000

ctccagagcc tccagaccta tgtgacacag cagctgatca gggccgccga gatcagggcc     3060

agcgccaatc tggcagcaac caagatgtcc gagtgcgtgc tgggccagtc taagagagtg     3120

gacttttgtg gcaagggcta tcacctgatg tccttccctc agtctgcccc acacggcgtg     3180

gtgtttctgc acgtgaccta cgtgcccgcc caggagaagc agttcaccac agcccctgcc     3240

atctgccacg atggcaaggc ccactttcca agggagggcg tgttcgtgtc ccagggcacc     3300

cactggtttg tgacacagcg caatttctac gagccccaga tcatcaccac agacaacacc     3360

ttcgtgagcg gcaactgtga cgtggtcatc ggcatcgtgc agaataccgt gtatgatcca     3420

ctccagcccg agctggacag ctttaaggag gagctggata agtatttcaa gcaacacacc     3480

tcccctgacg tggatctggg cgacatcagc ggcatccaag cctccgtggt gaacatccag     3540

aaggagatcg accgcctgaa cgaggtggct aagaatctgc aggagagcct gatcgacctc     3600

caggagctgg gcaagtatga gcagtacatc aagtggccct ggtacatctg gctgggcttc     3660

atcgccggcc tgatcgccat cgtgatggtg accatcatgc tgtgctgtat gacatcctgc     3720

tgttcttgcc tgaagggctg ctgtagctgt ggctcctgct gtaagtttga cgaggatgac     3780

tctgaacctg tgctgaaggg cgtgaagctg cattacacct aa                        3822


<210>  6
<211>  1273
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  S-(deg-S2)

<400>  6

Met Phe Val Phe Leu Val Leu Leu Pro Leu Val Ser Ser Gln Cys Val 
1               5                   10                  15      


Asn Leu Thr Thr Arg Thr Gln Leu Pro Pro Ala Tyr Thr Asn Ser Phe 
            20                  25                  30          


Thr Arg Gly Val Tyr Tyr Pro Asp Lys Val Phe Arg Ser Ser Val Leu 
        35                  40                  45              


His Ser Thr Gln Asp Leu Phe Leu Pro Phe Phe Ser Asn Val Thr Trp 
    50                  55                  60                  


Phe His Ala Ile His Val Ser Gly Thr Asn Gly Thr Lys Arg Phe Asp 
65                  70                  75                  80  


Asn Pro Val Leu Pro Phe Asn Asp Gly Val Tyr Phe Ala Ser Thr Glu 
                85                  90                  95      


Lys Ser Asn Ile Ile Arg Gly Trp Ile Phe Gly Thr Thr Leu Asp Ser 
            100                 105                 110         


Lys Thr Gln Ser Leu Leu Ile Val Asn Asn Ala Thr Asn Val Val Ile 
        115                 120                 125             


Lys Val Cys Glu Phe Gln Phe Cys Asn Asp Pro Phe Leu Gly Val Tyr 
    130                 135                 140                 


Tyr His Lys Asn Asn Lys Ser Trp Met Glu Ser Glu Phe Arg Val Tyr 
145                 150                 155                 160 


Ser Ser Ala Asn Asn Cys Thr Phe Glu Tyr Val Ser Gln Pro Phe Leu 
                165                 170                 175     


Met Asp Leu Glu Gly Lys Gln Gly Asn Phe Lys Asn Leu Arg Glu Phe 
            180                 185                 190         


Val Phe Lys Asn Ile Asp Gly Tyr Phe Lys Ile Tyr Ser Lys His Thr 
        195                 200                 205             


Pro Ile Asn Leu Val Arg Asp Leu Pro Gln Gly Phe Ser Ala Leu Glu 
    210                 215                 220                 


Pro Leu Val Asp Leu Pro Ile Gly Ile Asn Ile Thr Arg Phe Gln Thr 
225                 230                 235                 240 


Leu Leu Ala Leu His Arg Ser Tyr Leu Thr Pro Gly Asp Ser Ser Ser 
                245                 250                 255     


Gly Trp Thr Ala Gly Ala Ala Ala Tyr Tyr Val Gly Tyr Leu Gln Pro 
            260                 265                 270         


Arg Thr Phe Leu Leu Lys Tyr Asn Glu Asn Gly Thr Ile Thr Asp Ala 
        275                 280                 285             


Val Asp Cys Ala Leu Asp Pro Leu Ser Glu Thr Lys Cys Thr Leu Lys 
    290                 295                 300                 


Ser Phe Thr Val Glu Lys Gly Ile Tyr Gln Thr Ser Asn Phe Arg Val 
305                 310                 315                 320 


Gln Pro Thr Glu Ser Ile Val Arg Phe Pro Asn Ile Thr Asn Leu Cys 
                325                 330                 335     


Pro Phe Gly Glu Val Phe Asn Ala Thr Arg Phe Ala Ser Val Tyr Ala 
            340                 345                 350         


Trp Asn Arg Lys Arg Ile Ser Asn Cys Val Ala Asp Tyr Ser Val Leu 
        355                 360                 365             


Tyr Asn Ser Ala Ser Phe Ser Thr Phe Lys Cys Tyr Gly Val Ser Pro 
    370                 375                 380                 


Thr Lys Leu Asn Asp Leu Cys Phe Thr Asn Val Tyr Ala Asp Ser Phe 
385                 390                 395                 400 


Val Ile Arg Gly Asp Glu Val Arg Gln Ile Ala Pro Gly Gln Thr Gly 
                405                 410                 415     


Lys Ile Ala Asp Tyr Asn Tyr Lys Leu Pro Asp Asp Phe Thr Gly Cys 
            420                 425                 430         


Val Ile Ala Trp Asn Ser Asn Asn Leu Asp Ser Lys Val Gly Gly Asn 
        435                 440                 445             


Tyr Asn Tyr Leu Tyr Arg Leu Phe Arg Lys Ser Asn Leu Lys Pro Phe 
    450                 455                 460                 


Glu Arg Asp Ile Ser Thr Glu Ile Tyr Gln Ala Gly Ser Thr Pro Cys 
465                 470                 475                 480 


Asn Gly Val Glu Gly Phe Asn Cys Tyr Phe Pro Leu Gln Ser Tyr Gly 
                485                 490                 495     


Phe Gln Pro Thr Asn Gly Val Gly Tyr Gln Pro Tyr Arg Val Val Val 
            500                 505                 510         


Leu Ser Phe Glu Leu Leu His Ala Pro Ala Thr Val Cys Gly Pro Lys 
        515                 520                 525             


Lys Ser Thr Asn Leu Val Lys Asn Lys Cys Val Asn Phe Asn Phe Asn 
    530                 535                 540                 


Gly Leu Thr Gly Thr Gly Val Leu Thr Glu Ser Asn Lys Lys Phe Leu 
545                 550                 555                 560 


Pro Phe Gln Gln Phe Gly Arg Asp Ile Ala Asp Thr Thr Asp Ala Val 
                565                 570                 575     


Arg Asp Pro Gln Thr Leu Glu Ile Leu Asp Ile Thr Pro Cys Ser Phe 
            580                 585                 590         


Gly Gly Val Ser Val Ile Thr Pro Gly Thr Asn Thr Ser Asn Gln Val 
        595                 600                 605             


Ala Val Leu Tyr Gln Asp Val Asn Cys Thr Glu Val Pro Val Ala Ile 
    610                 615                 620                 


His Ala Asp Gln Leu Thr Pro Thr Trp Arg Val Tyr Ser Thr Gly Ser 
625                 630                 635                 640 


Asn Val Phe Gln Thr Arg Ala Gly Cys Leu Ile Gly Ala Glu His Val 
                645                 650                 655     


Asn Asn Ser Tyr Glu Cys Asp Ile Pro Ile Gly Ala Gly Ile Cys Ala 
            660                 665                 670         


Ser Tyr Gln Thr Gln Thr Asn Ser Pro Arg Arg Ala Arg Ser Val Ala 
        675                 680                 685             


Ser Gln Ser Ile Ile Ala Tyr Thr Met Ser Leu Gly Ala Glu Asn Ser 
    690                 695                 700                 


Val Ala Tyr Ser Gln Asn Ser Ile Ala Ile Pro Thr Gln Phe Thr Ile 
705                 710                 715                 720 


Ser Val Thr Thr Glu Ile Leu Pro Val Ser Met Thr Lys Thr Ser Val 
                725                 730                 735     


Asp Cys Thr Met Tyr Ile Cys Gly Asp Ser Thr Glu Cys Ser Asn Leu 
            740                 745                 750         


Leu Leu Gln Tyr Gly Ser Phe Cys Thr Gln Leu Asn Arg Ala Leu Thr 
        755                 760                 765             


Gly Ile Ala Val Glu Gln Asp Lys Asn Thr Gln Glu Val Phe Ala Gln 
    770                 775                 780                 


Val Lys Gln Ile Tyr Lys Thr Pro Pro Ile Lys Asp Phe Gly Gly Phe 
785                 790                 795                 800 


Gln Phe Ser Gln Ile Leu Pro Asp Pro Ser Lys Pro Ser Lys Arg Ser 
                805                 810                 815     


Phe Ile Glu Asp Leu Leu Phe Asn Lys Val Thr Leu Ala Asp Ala Gly 
            820                 825                 830         


Phe Ile Lys Gln Tyr Gly Asp Cys Leu Gly Asp Ile Ala Ala Arg Asp 
        835                 840                 845             


Leu Ile Cys Ala Gln Lys Phe Asn Gly Leu Thr Val Leu Pro Pro Leu 
    850                 855                 860                 


Leu Thr Asp Glu Met Ile Ala Gln Tyr Thr Ser Ala Leu Leu Ala Gly 
865                 870                 875                 880 


Thr Ile Thr Ser Gly Trp Thr Phe Gly Ala Gly Ala Ala Leu Gln Ile 
                885                 890                 895     


Pro Phe Ala Met Gln Met Ala Tyr Arg Phe Asn Gly Ile Gly Val Thr 
            900                 905                 910         


Gln Asn Val Leu Tyr Glu Asn Gln Lys Leu Ile Ala Asn Gln Phe Asn 
        915                 920                 925             


Ser Ala Ile Gly Lys Ile Gln Asp Ser Leu Ser Ser Thr Ala Ser Ala 
    930                 935                 940                 


Leu Gly Lys Leu Gln Asp Val Val Asn Gln Asn Ala Gln Ala Leu Asn 
945                 950                 955                 960 


Thr Leu Val Lys Gln Leu Ser Ser Asn Phe Gly Ala Ile Ser Ser Val 
                965                 970                 975     


Leu Asn Asp Ile Leu Ser Arg Leu Asp Pro Pro Glu Ala Glu Val Gln 
            980                 985                 990         


Ile Asp Arg Leu Ile Thr Gly Arg  Leu Gln Ser Leu Gln  Thr Tyr Val 
        995                 1000                 1005             


Thr Gln  Gln Leu Ile Arg Ala  Ala Glu Ile Arg Ala  Ser Ala Asn 
    1010                 1015                 1020             


Leu Ala  Ala Thr Lys Met Ser  Glu Cys Val Leu Gly  Gln Ser Lys 
    1025                 1030                 1035             


Arg Val  Asp Phe Cys Gly Lys  Gly Tyr His Leu Met  Ser Phe Pro 
    1040                 1045                 1050             


Gln Ser  Ala Pro His Gly Val  Val Phe Leu His Val  Thr Tyr Val 
    1055                 1060                 1065             


Pro Ala  Gln Glu Lys Gln Phe  Thr Thr Ala Pro Ala  Ile Cys His 
    1070                 1075                 1080             


Asp Gly  Lys Ala His Phe Pro  Arg Glu Gly Val Phe  Val Ser Gln 
    1085                 1090                 1095             


Gly Thr  His Trp Phe Val Thr  Gln Arg Asn Phe Tyr  Glu Pro Gln 
    1100                 1105                 1110             


Ile Ile  Thr Thr Asp Asn Thr  Phe Val Ser Gly Asn  Cys Asp Val 
    1115                 1120                 1125             


Val Ile  Gly Ile Val Gln Asn  Thr Val Tyr Asp Pro  Leu Gln Pro 
    1130                 1135                 1140             


Glu Leu  Asp Ser Phe Lys Glu  Glu Leu Asp Lys Tyr  Phe Lys Gln 
    1145                 1150                 1155             


His Thr  Ser Pro Asp Val Asp  Leu Gly Asp Ile Ser  Gly Ile Gln 
    1160                 1165                 1170             


Ala Ser  Val Val Asn Ile Gln  Lys Glu Ile Asp Arg  Leu Asn Glu 
    1175                 1180                 1185             


Val Ala  Lys Asn Leu Gln Glu  Ser Leu Ile Asp Leu  Gln Glu Leu 
    1190                 1195                 1200             


Gly Lys  Tyr Glu Gln Tyr Ile  Lys Trp Pro Trp Tyr  Ile Trp Leu 
    1205                 1210                 1215             


Gly Phe  Ile Ala Gly Leu Ile  Ala Ile Val Met Val  Thr Ile Met 
    1220                 1225                 1230             


Leu Cys  Cys Met Thr Ser Cys  Cys Ser Cys Leu Lys  Gly Cys Cys 
    1235                 1240                 1245             


Ser Cys  Gly Ser Cys Cys Lys  Phe Asp Glu Asp Asp  Ser Glu Pro 
    1250                 1255                 1260             


Val Leu  Lys Gly Val Lys Leu  His Tyr Thr 
    1265                 1270             


<210>  7
<211>  3822
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  S-(S2-1194)

<400>  7
atgttcgtct tcctggtcct gctgcctctg gtctcctcac agtgcgtcaa tctgacaact       60

cggactcagc tgccacctgc ttatactaat agcttcacca gaggcgtgta ctatcctgac      120

aaggtgttta gaagctccgt gctgcactct acacaggatc tgtttctgcc attctttagc      180

aacgtgacct ggttccacgc catccacgtg agcggcacca atggcacaaa gcggttcgac      240

aatcccgtgc tgccttttaa cgatggcgtg tacttcgcct ctaccgagaa gagcaacatc      300

atcagaggct ggatctttgg caccacactg gactccaaga cacagtctct gctgatcgtg      360

aacaatgcca ccaacgtggt catcaaggtg tgcgagttcc agttttgtaa tgatcccttc      420

ctgggcgtgt actatcacaa gaacaataag agctggatgg agtccgagtt tagagtgtat      480

tctagcgcca acaactgcac atttgagtac gtgagccagc ctttcctgat ggacctggag      540

ggcaagcagg gcaatttcaa gaacctgagg gagttcgtgt ttaagaatat cgacggctac      600

ttcaaaatct actctaagca cacccccatc aacctggtgc gcgacctgcc tcagggcttc      660

agcgccctgg agcccctggt ggatctgcct atcggcatca acatcacccg gtttcagaca      720

ctgctggccc tgcacagaag ctacctgaca cccggcgact cctctagcgg atggaccgcc      780

ggcgctgccg cctactatgt gggctacctc cagccccgga ccttcctgct gaagtacaac      840

gagaatggca ccatcacaga cgcagtggat tgcgccctgg accccctgag cgagacaaag      900

tgtacactga agtcctttac cgtggagaag ggcatctatc agacatccaa tttcagggtg      960

cagccaaccg agtctatcgt gcgctttcct aatatcacaa acctgtgccc atttggcgag     1020

gtgttcaacg caacccgctt cgccagcgtg tacgcctgga ataggaagcg gatcagcaac     1080

tgcgtggccg actatagcgt gctgtacaac tccgcctctt tcagcacctt taagtgctat     1140

ggcgtgtccc ccacaaagct gaatgacctg tgctttacca acgtctacgc cgattctttc     1200

gtgatcaggg gcgacgaggt gcgccagatc gcccccggcc agacaggcaa gatcgcagac     1260

tacaattata agctgccaga cgatttcacc ggctgcgtga tcgcctggaa cagcaacaat     1320

ctggattcca aagtgggcgg caactacaat tatctgtacc ggctgtttag aaagagcaat     1380

ctgaagccct tcgagaggga catctctaca gaaatctacc aggccggcag caccccttgc     1440

aatggcgtgg agggctttaa ctgttatttc ccactccagt cctacggctt ccagcccaca     1500

aacggcgtgg gctatcagcc ttaccgcgtg gtggtgctga gctttgagct gctgcacgcc     1560

ccagcaacag tgtgcggccc caagaagtcc accaatctgg tgaagaacaa gtgcgtgaac     1620

ttcaacttca acggcctgac cggcacaggc gtgctgaccg agtccaacaa gaagttcctg     1680

ccatttcagc agttcggcag ggacatcgca gataccacag acgccgtgcg cgacccacag     1740

accctggaga tcctggacat cacaccctgc tctttcggcg gcgtgagcgt gatcacaccc     1800

ggcaccaata caagcaacca ggtggccgtg ctgtatcagg acgtgaattg taccgaggtg     1860

cccgtggcta tccacgccga tcagctgacc ccaacatggc gggtgtacag caccggctcc     1920

aacgtcttcc agacaagagc cggatgcctg atcggagcag agcacgtgaa caattcctat     1980

gagtgcgaca tcccaatcgg cgccggcatc tgtgcctctt accagaccca gacaaactct     2040

cccagaagag cccggagcgt ggcctcccag tctatcatcg cctataccat gtccctgggc     2100

gccgagaaca gcgtggccta ctctcagaat agcatcgcca tcccaaccca gttcacaatc     2160

tctgtgacca cagagatcct gcccgtgtcc atgaccaaga catctgtgga ctgcacaatg     2220

tatatctgtg gcgattctac cgagtgcagc aacctgctgc tccagtacgg cagcttttgt     2280

acccagctga atagagccct gacaggcatc gccgtggagc aggataagaa cacacaggag     2340

gtgttcgccc aggtgaagca aatctacaag acccccccta tcaaggactt tggcggcttc     2400

caattttccc agatcctgcc tgatccatcc aagccttcta agcggagctt tatcgaggac     2460

ctgctgttca acaaggtgac cctggccgat gccggcttca tcaagcagta tggcgattgc     2520

ctgggcgaca tcgcagccag ggacctgatc tgcgcccaga agtttaatgg cctgaccgtg     2580

ctgccacccc tgctgacaga tgagatgatc gcacagtaca caagcgccct gctggccggc     2640

accatcacat ccggatggac cttcggcgca ggagccgccc tccagatccc ctttgccatg     2700

cagatggcct ataggttcaa cggcatcggc gtgacccaga atgtgctgta cgagaaccag     2760

aagctgatcg ccaatcagtt taactccgcc atcggcaaga tccaggacag cctgtcctct     2820

acagccagcg ccctgggcaa gctccaggat gtggtgaatc agaacgccca ggccctgaat     2880

accctggtga agcagctgag cagcaacttc ggcgccatct ctagcgtgct gaatgacatc     2940

ctgagccggc tggacaaggt ggaggcagag gtgcagatcg accggctgat caccggccgg     3000

ctccagagcc tccagaccta tgtgacacag cagctgatca gggccgccga gatcagggcc     3060

agcgccaatc tggcagcaac caagatgtcc gagtgcgtgc tgggccagtc taagagagtg     3120

gacttttgtg gcaagggcta tcacctgatg tccttccctc agtctgcccc acacggcgtg     3180

gtgtttctgc acgtgaccta cgtgcccgcc caggagaagc agttcaccac agcccctgcc     3240

atctgccacg atggcaaggc ccactttcca agggagggcg tgttcgtgtc ccagggcacc     3300

cactggtttg tgacacagcg caatttctac gagccccaga tcatcaccac agacaacacc     3360

ttcgtgagcg gcaactgtga cgtggtcatc ggcatcgtgc agaataccgt gtatgatcca     3420

ctccagcccg agctggacag ctttaaggag gagctggata agtatttcaa gcaacacacc     3480

tcccctgacg tggatctggg cgacatcagc ggcatccaag cctccgtggt gaacatccag     3540

aaggagatcg accgcctgaa cgaggtggct aagaatctga acgagagcct gatcgacctc     3600

caggagctgg gcaagtatga gcagtacatc aagtggccct ggtacatctg gctgggcttc     3660

atcgccggcc tgatcgccat cgtgatggtg accatcatgc tgtgctgtat gacatcctgc     3720

tgttcttgcc tgaagggctg ctgtagctgt ggctcctgct gtaagtttga cgaggatgac     3780

tctgaacctg tgctgaaggg cgtgaagctg cattacacct aa                        3822


<210>  8
<211>  1273
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  S-(S2-1194)

<400>  8

Met Phe Val Phe Leu Val Leu Leu Pro Leu Val Ser Ser Gln Cys Val 
1               5                   10                  15      


Asn Leu Thr Thr Arg Thr Gln Leu Pro Pro Ala Tyr Thr Asn Ser Phe 
            20                  25                  30          


Thr Arg Gly Val Tyr Tyr Pro Asp Lys Val Phe Arg Ser Ser Val Leu 
        35                  40                  45              


His Ser Thr Gln Asp Leu Phe Leu Pro Phe Phe Ser Asn Val Thr Trp 
    50                  55                  60                  


Phe His Ala Ile His Val Ser Gly Thr Asn Gly Thr Lys Arg Phe Asp 
65                  70                  75                  80  


Asn Pro Val Leu Pro Phe Asn Asp Gly Val Tyr Phe Ala Ser Thr Glu 
                85                  90                  95      


Lys Ser Asn Ile Ile Arg Gly Trp Ile Phe Gly Thr Thr Leu Asp Ser 
            100                 105                 110         


Lys Thr Gln Ser Leu Leu Ile Val Asn Asn Ala Thr Asn Val Val Ile 
        115                 120                 125             


Lys Val Cys Glu Phe Gln Phe Cys Asn Asp Pro Phe Leu Gly Val Tyr 
    130                 135                 140                 


Tyr His Lys Asn Asn Lys Ser Trp Met Glu Ser Glu Phe Arg Val Tyr 
145                 150                 155                 160 


Ser Ser Ala Asn Asn Cys Thr Phe Glu Tyr Val Ser Gln Pro Phe Leu 
                165                 170                 175     


Met Asp Leu Glu Gly Lys Gln Gly Asn Phe Lys Asn Leu Arg Glu Phe 
            180                 185                 190         


Val Phe Lys Asn Ile Asp Gly Tyr Phe Lys Ile Tyr Ser Lys His Thr 
        195                 200                 205             


Pro Ile Asn Leu Val Arg Asp Leu Pro Gln Gly Phe Ser Ala Leu Glu 
    210                 215                 220                 


Pro Leu Val Asp Leu Pro Ile Gly Ile Asn Ile Thr Arg Phe Gln Thr 
225                 230                 235                 240 


Leu Leu Ala Leu His Arg Ser Tyr Leu Thr Pro Gly Asp Ser Ser Ser 
                245                 250                 255     


Gly Trp Thr Ala Gly Ala Ala Ala Tyr Tyr Val Gly Tyr Leu Gln Pro 
            260                 265                 270         


Arg Thr Phe Leu Leu Lys Tyr Asn Glu Asn Gly Thr Ile Thr Asp Ala 
        275                 280                 285             


Val Asp Cys Ala Leu Asp Pro Leu Ser Glu Thr Lys Cys Thr Leu Lys 
    290                 295                 300                 


Ser Phe Thr Val Glu Lys Gly Ile Tyr Gln Thr Ser Asn Phe Arg Val 
305                 310                 315                 320 


Gln Pro Thr Glu Ser Ile Val Arg Phe Pro Asn Ile Thr Asn Leu Cys 
                325                 330                 335     


Pro Phe Gly Glu Val Phe Asn Ala Thr Arg Phe Ala Ser Val Tyr Ala 
            340                 345                 350         


Trp Asn Arg Lys Arg Ile Ser Asn Cys Val Ala Asp Tyr Ser Val Leu 
        355                 360                 365             


Tyr Asn Ser Ala Ser Phe Ser Thr Phe Lys Cys Tyr Gly Val Ser Pro 
    370                 375                 380                 


Thr Lys Leu Asn Asp Leu Cys Phe Thr Asn Val Tyr Ala Asp Ser Phe 
385                 390                 395                 400 


Val Ile Arg Gly Asp Glu Val Arg Gln Ile Ala Pro Gly Gln Thr Gly 
                405                 410                 415     


Lys Ile Ala Asp Tyr Asn Tyr Lys Leu Pro Asp Asp Phe Thr Gly Cys 
            420                 425                 430         


Val Ile Ala Trp Asn Ser Asn Asn Leu Asp Ser Lys Val Gly Gly Asn 
        435                 440                 445             


Tyr Asn Tyr Leu Tyr Arg Leu Phe Arg Lys Ser Asn Leu Lys Pro Phe 
    450                 455                 460                 


Glu Arg Asp Ile Ser Thr Glu Ile Tyr Gln Ala Gly Ser Thr Pro Cys 
465                 470                 475                 480 


Asn Gly Val Glu Gly Phe Asn Cys Tyr Phe Pro Leu Gln Ser Tyr Gly 
                485                 490                 495     


Phe Gln Pro Thr Asn Gly Val Gly Tyr Gln Pro Tyr Arg Val Val Val 
            500                 505                 510         


Leu Ser Phe Glu Leu Leu His Ala Pro Ala Thr Val Cys Gly Pro Lys 
        515                 520                 525             


Lys Ser Thr Asn Leu Val Lys Asn Lys Cys Val Asn Phe Asn Phe Asn 
    530                 535                 540                 


Gly Leu Thr Gly Thr Gly Val Leu Thr Glu Ser Asn Lys Lys Phe Leu 
545                 550                 555                 560 


Pro Phe Gln Gln Phe Gly Arg Asp Ile Ala Asp Thr Thr Asp Ala Val 
                565                 570                 575     


Arg Asp Pro Gln Thr Leu Glu Ile Leu Asp Ile Thr Pro Cys Ser Phe 
            580                 585                 590         


Gly Gly Val Ser Val Ile Thr Pro Gly Thr Asn Thr Ser Asn Gln Val 
        595                 600                 605             


Ala Val Leu Tyr Gln Asp Val Asn Cys Thr Glu Val Pro Val Ala Ile 
    610                 615                 620                 


His Ala Asp Gln Leu Thr Pro Thr Trp Arg Val Tyr Ser Thr Gly Ser 
625                 630                 635                 640 


Asn Val Phe Gln Thr Arg Ala Gly Cys Leu Ile Gly Ala Glu His Val 
                645                 650                 655     


Asn Asn Ser Tyr Glu Cys Asp Ile Pro Ile Gly Ala Gly Ile Cys Ala 
            660                 665                 670         


Ser Tyr Gln Thr Gln Thr Asn Ser Pro Arg Arg Ala Arg Ser Val Ala 
        675                 680                 685             


Ser Gln Ser Ile Ile Ala Tyr Thr Met Ser Leu Gly Ala Glu Asn Ser 
    690                 695                 700                 


Val Ala Tyr Ser Gln Asn Ser Ile Ala Ile Pro Thr Gln Phe Thr Ile 
705                 710                 715                 720 


Ser Val Thr Thr Glu Ile Leu Pro Val Ser Met Thr Lys Thr Ser Val 
                725                 730                 735     


Asp Cys Thr Met Tyr Ile Cys Gly Asp Ser Thr Glu Cys Ser Asn Leu 
            740                 745                 750         


Leu Leu Gln Tyr Gly Ser Phe Cys Thr Gln Leu Asn Arg Ala Leu Thr 
        755                 760                 765             


Gly Ile Ala Val Glu Gln Asp Lys Asn Thr Gln Glu Val Phe Ala Gln 
    770                 775                 780                 


Val Lys Gln Ile Tyr Lys Thr Pro Pro Ile Lys Asp Phe Gly Gly Phe 
785                 790                 795                 800 


Gln Phe Ser Gln Ile Leu Pro Asp Pro Ser Lys Pro Ser Lys Arg Ser 
                805                 810                 815     


Phe Ile Glu Asp Leu Leu Phe Asn Lys Val Thr Leu Ala Asp Ala Gly 
            820                 825                 830         


Phe Ile Lys Gln Tyr Gly Asp Cys Leu Gly Asp Ile Ala Ala Arg Asp 
        835                 840                 845             


Leu Ile Cys Ala Gln Lys Phe Asn Gly Leu Thr Val Leu Pro Pro Leu 
    850                 855                 860                 


Leu Thr Asp Glu Met Ile Ala Gln Tyr Thr Ser Ala Leu Leu Ala Gly 
865                 870                 875                 880 


Thr Ile Thr Ser Gly Trp Thr Phe Gly Ala Gly Ala Ala Leu Gln Ile 
                885                 890                 895     


Pro Phe Ala Met Gln Met Ala Tyr Arg Phe Asn Gly Ile Gly Val Thr 
            900                 905                 910         


Gln Asn Val Leu Tyr Glu Asn Gln Lys Leu Ile Ala Asn Gln Phe Asn 
        915                 920                 925             


Ser Ala Ile Gly Lys Ile Gln Asp Ser Leu Ser Ser Thr Ala Ser Ala 
    930                 935                 940                 


Leu Gly Lys Leu Gln Asp Val Val Asn Gln Asn Ala Gln Ala Leu Asn 
945                 950                 955                 960 


Thr Leu Val Lys Gln Leu Ser Ser Asn Phe Gly Ala Ile Ser Ser Val 
                965                 970                 975     


Leu Asn Asp Ile Leu Ser Arg Leu Asp Pro Pro Glu Ala Glu Val Gln 
            980                 985                 990         


Ile Asp Arg Leu Ile Thr Gly Arg  Leu Gln Ser Leu Gln  Thr Tyr Val 
        995                 1000                 1005             


Thr Gln  Gln Leu Ile Arg Ala  Ala Glu Ile Arg Ala  Ser Ala Asn 
    1010                 1015                 1020             


Leu Ala  Ala Thr Lys Met Ser  Glu Cys Val Leu Gly  Gln Ser Lys 
    1025                 1030                 1035             


Arg Val  Asp Phe Cys Gly Lys  Gly Tyr His Leu Met  Ser Phe Pro 
    1040                 1045                 1050             


Gln Ser  Ala Pro His Gly Val  Val Phe Leu His Val  Thr Tyr Val 
    1055                 1060                 1065             


Pro Ala  Gln Glu Lys Gln Phe  Thr Thr Ala Pro Ala  Ile Cys His 
    1070                 1075                 1080             


Asp Gly  Lys Ala His Phe Pro  Arg Glu Gly Val Phe  Val Ser Gln 
    1085                 1090                 1095             


Gly Thr  His Trp Phe Val Thr  Gln Arg Asn Phe Tyr  Glu Pro Gln 
    1100                 1105                 1110             


Ile Ile  Thr Thr Asp Asn Thr  Phe Val Ser Gly Asn  Cys Asp Val 
    1115                 1120                 1125             


Val Ile  Gly Ile Val Gln Asn  Thr Val Tyr Asp Pro  Leu Gln Pro 
    1130                 1135                 1140             


Glu Leu  Asp Ser Phe Lys Glu  Glu Leu Asp Lys Tyr  Phe Lys Gln 
    1145                 1150                 1155             


His Thr  Ser Pro Asp Val Asp  Leu Gly Asp Ile Ser  Gly Ile Gln 
    1160                 1165                 1170             


Ala Ser  Val Val Asn Ile Gln  Lys Glu Ile Asp Arg  Leu Asn Glu 
    1175                 1180                 1185             


Val Ala  Lys Asn Leu Asn Glu  Ser Leu Ile Asp Leu  Gln Glu Leu 
    1190                 1195                 1200             


Gly Lys  Tyr Glu Gln Tyr Ile  Lys Trp Pro Trp Tyr  Ile Trp Leu 
    1205                 1210                 1215             


Gly Phe  Ile Ala Gly Leu Ile  Ala Ile Val Met Val  Thr Ile Met 
    1220                 1225                 1230             


Leu Cys  Cys Met Thr Ser Cys  Cys Ser Cys Leu Lys  Gly Cys Cys 
    1235                 1240                 1245             


Ser Cys  Gly Ser Cys Cys Lys  Phe Asp Glu Asp Asp  Ser Glu Pro 
    1250                 1255                 1260             


Val Leu  Lys Gly Val Lys Leu  His Tyr Thr 
    1265                 1270             


<210>  9
<211>  3822
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  S-(deg-RBD-801)

<400>  9
atgttcgtct tcctggtcct gctgcctctg gtctcctcac agtgcgtcaa tctgacaact       60

cggactcagc tgccacctgc ttatactaat agcttcacca gaggcgtgta ctatcctgac      120

aaggtgttta gaagctccgt gctgcactct acacaggatc tgtttctgcc attctttagc      180

aacgtgacct ggttccacgc catccacgtg agcggcacca atggcacaaa gcggttcgac      240

aatcccgtgc tgccttttaa cgatggcgtg tacttcgcct ctaccgagaa gagcaacatc      300

atcagaggct ggatctttgg caccacactg gactccaaga cacagtctct gctgatcgtg      360

aacaatgcca ccaacgtggt catcaaggtg tgcgagttcc agttttgtaa tgatcccttc      420

ctgggcgtgt actatcacaa gaacaataag agctggatgg agtccgagtt tagagtgtat      480

tctagcgcca acaactgcac atttgagtac gtgagccagc ctttcctgat ggacctggag      540

ggcaagcagg gcaatttcaa gaacctgagg gagttcgtgt ttaagaatat cgacggctac      600

ttcaaaatct actctaagca cacccccatc aacctggtgc gcgacctgcc tcagggcttc      660

agcgccctgg agcccctggt ggatctgcct atcggcatca acatcacccg gtttcagaca      720

ctgctggccc tgcacagaag ctacctgaca cccggcgact cctctagcgg atggaccgcc      780

ggcgctgccg cctactatgt gggctacctc cagccccgga ccttcctgct gaagtacaac      840

gagaatggca ccatcacaga cgcagtggat tgcgccctgg accccctgag cgagacaaag      900

tgtacactga agtcctttac cgtggagaag ggcatctatc agacatccaa tttcagggtg      960

cagccagccg aggcgatcgt gcgctttcct gaaatcacaa acctgtgccc atttggcgag     1020

gtgttcgagg caacccgctt cgccagcgtg tacgcctgga ataggaagcg gatcagcaac     1080

tgcgtggccg actatagcgt gctgtacaac tccgcctctt tcagcacctt taagtgctat     1140

ggcgtgtccc ccacaaagct gaatgacctg tgctttacca acgtctacgc cgattctttc     1200

gtgatcaggg gcgacgaggt gcgccagatc gcccccggcc agacaggcaa gatcgcagac     1260

tacaattata agctgccaga cgatttcacc ggctgcgtga tcgcctggaa cagcaacaat     1320

ctggattcca aagtgggcgg caactacaat tatctgtacc ggctgtttag aaagagcaat     1380

ctgaagccct tcgagaggga catctctaca gaaatctacc aggccggcag caccccttgc     1440

aatggcgtgg agggctttaa ctgttatttc ccactccagt cctacggctt ccagcccaca     1500

aacggcgtgg gctatcagcc ttaccgcgtg gtggtgctga gctttgagct gctgcacgcc     1560

ccagcaacag tgtgcggccc caagaagtcc accaatctgg tgaagaacaa gtgcgtgaac     1620

ttcaacttca acggcctgac cggcacaggc gtgctgaccg agtccaacaa gaagttcctg     1680

ccatttcagc agttcggcag ggacatcgca gataccacag acgccgtgcg cgacccacag     1740

accctggaga tcctggacat cacaccctgc tctttcggcg gcgtgagcgt gatcacaccc     1800

ggcaccaata caagcaacca ggtggccgtg ctgtatcagg acgtgaattg taccgaggtg     1860

cccgtggcta tccacgccga tcagctgacc ccaacatggc gggtgtacag caccggctcc     1920

aacgtcttcc agacaagagc cggatgcctg atcggagcag agcacgtgaa caattcctat     1980

gagtgcgaca tcccaatcgg cgccggcatc tgtgcctctt accagaccca gacaaactct     2040

cccagaagag cccggagcgt ggcctcccag tctatcatcg cctataccat gtccctgggc     2100

gccgagaaca gcgtggccta ctctaacaat agcatcgcca tcccaaccaa cttcacaatc     2160

tctgtgacca cagagatcct gcccgtgtcc atgaccaaga catctgtgga ctgcacaatg     2220

tatatctgtg gcgattctac cgagtgcagc aacctgctgc tccagtacgg cagcttttgt     2280

acccagctga atagagccct gacaggcatc gccgtggagc aggataagaa cacacaggag     2340

gtgttcgccc aggtgaagca aatctacaag acccccccta tcaaggactt tggcggcttc     2400

caattttccc agatcctgcc tgatccatcc aagccttcta agcggagctt tatcgaggac     2460

ctgctgttca acaaggtgac cctggccgat gccggcttca tcaagcagta tggcgattgc     2520

ctgggcgaca tcgcagccag ggacctgatc tgcgcccaga agtttaatgg cctgaccgtg     2580

ctgccacccc tgctgacaga tgagatgatc gcacagtaca caagcgccct gctggccggc     2640

accatcacat ccggatggac cttcggcgca ggagccgccc tccagatccc ctttgccatg     2700

cagatggcct ataggttcaa cggcatcggc gtgacccaga atgtgctgta cgagaaccag     2760

aagctgatcg ccaatcagtt taactccgcc atcggcaaga tccaggacag cctgtcctct     2820

acagccagcg ccctgggcaa gctccaggat gtggtgaatc agaacgccca ggccctgaat     2880

accctggtga agcagctgag cagcaacttc ggcgccatct ctagcgtgct gaatgacatc     2940

ctgagccggc tggacaaggt ggaggcagag gtgcagatcg accggctgat caccggccgg     3000

ctccagagcc tccagaccta tgtgacacag cagctgatca gggccgccga gatcagggcc     3060

agcgccaatc tggcagcaac caagatgtcc gagtgcgtgc tgggccagtc taagagagtg     3120

gacttttgtg gcaagggcta tcacctgatg tccttccctc agtctgcccc acacggcgtg     3180

gtgtttctgc acgtgaccta cgtgcccgcc caggagaaga acttcaccac agcccctgcc     3240

atctgccacg atggcaaggc ccactttcca agggagggcg tgttcgtgtc caacggcacc     3300

cactggtttg tgacacagcg caatttctac gagccccaga tcatcaccac agacaacacc     3360

ttcgtgagcg gcaactgtga cgtggtcatc ggcatcgtga acaataccgt gtatgatcca     3420

ctccagcccg agctggacag ctttaaggag gagctggata agtatttcaa gaatcacacc     3480

tcccctgacg tggatctggg cgacatcagc ggcatcaatg cctccgtggt gaacatccag     3540

aaggagatcg accgcctgaa cgaggtggct aagaatctga acgagagcct gatcgacctc     3600

caggagctgg gcaagtatga gcagtacatc aagtggccct ggtacatctg gctgggcttc     3660

atcgccggcc tgatcgccat cgtgatggtg accatcatgc tgtgctgtat gacatcctgc     3720

tgttcttgcc tgaagggctg ctgtagctgt ggctcctgct gtaagtttga cgaggatgac     3780

tctgaacctg tgctgaaggg cgtgaagctg cattacacct aa                        3822


<210>  10
<211>  1273
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  S-(deg-RBD-801)

<400>  10

Met Phe Val Phe Leu Val Leu Leu Pro Leu Val Ser Ser Gln Cys Val 
1               5                   10                  15      


Asn Leu Thr Thr Arg Thr Gln Leu Pro Pro Ala Tyr Thr Asn Ser Phe 
            20                  25                  30          


Thr Arg Gly Val Tyr Tyr Pro Asp Lys Val Phe Arg Ser Ser Val Leu 
        35                  40                  45              


His Ser Thr Gln Asp Leu Phe Leu Pro Phe Phe Ser Asn Val Thr Trp 
    50                  55                  60                  


Phe His Ala Ile His Val Ser Gly Thr Asn Gly Thr Lys Arg Phe Asp 
65                  70                  75                  80  


Asn Pro Val Leu Pro Phe Asn Asp Gly Val Tyr Phe Ala Ser Thr Glu 
                85                  90                  95      


Lys Ser Asn Ile Ile Arg Gly Trp Ile Phe Gly Thr Thr Leu Asp Ser 
            100                 105                 110         


Lys Thr Gln Ser Leu Leu Ile Val Asn Asn Ala Thr Asn Val Val Ile 
        115                 120                 125             


Lys Val Cys Glu Phe Gln Phe Cys Asn Asp Pro Phe Leu Gly Val Tyr 
    130                 135                 140                 


Tyr His Lys Asn Asn Lys Ser Trp Met Glu Ser Glu Phe Arg Val Tyr 
145                 150                 155                 160 


Ser Ser Ala Asn Asn Cys Thr Phe Glu Tyr Val Ser Gln Pro Phe Leu 
                165                 170                 175     


Met Asp Leu Glu Gly Lys Gln Gly Asn Phe Lys Asn Leu Arg Glu Phe 
            180                 185                 190         


Val Phe Lys Asn Ile Asp Gly Tyr Phe Lys Ile Tyr Ser Lys His Thr 
        195                 200                 205             


Pro Ile Asn Leu Val Arg Asp Leu Pro Gln Gly Phe Ser Ala Leu Glu 
    210                 215                 220                 


Pro Leu Val Asp Leu Pro Ile Gly Ile Asn Ile Thr Arg Phe Gln Thr 
225                 230                 235                 240 


Leu Leu Ala Leu His Arg Ser Tyr Leu Thr Pro Gly Asp Ser Ser Ser 
                245                 250                 255     


Gly Trp Thr Ala Gly Ala Ala Ala Tyr Tyr Val Gly Tyr Leu Gln Pro 
            260                 265                 270         


Arg Thr Phe Leu Leu Lys Tyr Asn Glu Asn Gly Thr Ile Thr Asp Ala 
        275                 280                 285             


Val Asp Cys Ala Leu Asp Pro Leu Ser Glu Thr Lys Cys Thr Leu Lys 
    290                 295                 300                 


Ser Phe Thr Val Glu Lys Gly Ile Tyr Gln Thr Ser Asn Phe Arg Val 
305                 310                 315                 320 


Gln Pro Ala Glu Ala Ile Val Arg Phe Pro Gln Ile Thr Asn Leu Cys 
                325                 330                 335     


Pro Phe Gly Glu Val Phe Gln Ala Thr Arg Phe Ala Ser Val Tyr Ala 
            340                 345                 350         


Trp Asn Arg Lys Arg Ile Ser Asn Cys Val Ala Asp Tyr Ser Val Leu 
        355                 360                 365             


Tyr Asn Ser Ala Ser Phe Ser Thr Phe Lys Cys Tyr Gly Val Ser Pro 
    370                 375                 380                 


Thr Lys Leu Asn Asp Leu Cys Phe Thr Asn Val Tyr Ala Asp Ser Phe 
385                 390                 395                 400 


Val Ile Arg Gly Asp Glu Val Arg Gln Ile Ala Pro Gly Gln Thr Gly 
                405                 410                 415     


Lys Ile Ala Asp Tyr Asn Tyr Lys Leu Pro Asp Asp Phe Thr Gly Cys 
            420                 425                 430         


Val Ile Ala Trp Asn Ser Asn Asn Leu Asp Ser Lys Val Gly Gly Asn 
        435                 440                 445             


Tyr Asn Tyr Leu Tyr Arg Leu Phe Arg Lys Ser Asn Leu Lys Pro Phe 
    450                 455                 460                 


Glu Arg Asp Ile Ser Thr Glu Ile Tyr Gln Ala Gly Ser Thr Pro Cys 
465                 470                 475                 480 


Asn Gly Val Glu Gly Phe Asn Cys Tyr Phe Pro Leu Gln Ser Tyr Gly 
                485                 490                 495     


Phe Gln Pro Thr Asn Gly Val Gly Tyr Gln Pro Tyr Arg Val Val Val 
            500                 505                 510         


Leu Ser Phe Glu Leu Leu His Ala Pro Ala Thr Val Cys Gly Pro Lys 
        515                 520                 525             


Lys Ser Thr Asn Leu Val Lys Asn Lys Cys Val Asn Phe Asn Phe Asn 
    530                 535                 540                 


Gly Leu Thr Gly Thr Gly Val Leu Thr Glu Ser Asn Lys Lys Phe Leu 
545                 550                 555                 560 


Pro Phe Gln Gln Phe Gly Arg Asp Ile Ala Asp Thr Thr Asp Ala Val 
                565                 570                 575     


Arg Asp Pro Gln Thr Leu Glu Ile Leu Asp Ile Thr Pro Cys Ser Phe 
            580                 585                 590         


Gly Gly Val Ser Val Ile Thr Pro Gly Thr Asn Thr Ser Asn Gln Val 
        595                 600                 605             


Ala Val Leu Tyr Gln Asp Val Asn Cys Thr Glu Val Pro Val Ala Ile 
    610                 615                 620                 


His Ala Asp Gln Leu Thr Pro Thr Trp Arg Val Tyr Ser Thr Gly Ser 
625                 630                 635                 640 


Asn Val Phe Gln Thr Arg Ala Gly Cys Leu Ile Gly Ala Glu His Val 
                645                 650                 655     


Asn Asn Ser Tyr Glu Cys Asp Ile Pro Ile Gly Ala Gly Ile Cys Ala 
            660                 665                 670         


Ser Tyr Gln Thr Gln Thr Asn Ser Pro Arg Arg Ala Arg Ser Val Ala 
        675                 680                 685             


Ser Gln Ser Ile Ile Ala Tyr Thr Met Ser Leu Gly Ala Glu Asn Ser 
    690                 695                 700                 


Val Ala Tyr Ser Asn Asn Ser Ile Ala Ile Pro Thr Asn Phe Thr Ile 
705                 710                 715                 720 


Ser Val Thr Thr Glu Ile Leu Pro Val Ser Met Thr Lys Thr Ser Val 
                725                 730                 735     


Asp Cys Thr Met Tyr Ile Cys Gly Asp Ser Thr Glu Cys Ser Asn Leu 
            740                 745                 750         


Leu Leu Gln Tyr Gly Ser Phe Cys Thr Gln Leu Asn Arg Ala Leu Thr 
        755                 760                 765             


Gly Ile Ala Val Glu Gln Asp Lys Asn Thr Gln Glu Val Phe Ala Gln 
    770                 775                 780                 


Val Lys Gln Ile Tyr Lys Thr Pro Pro Ile Lys Asp Phe Gly Gly Phe 
785                 790                 795                 800 


Gln Phe Ser Gln Ile Leu Pro Asp Pro Ser Lys Pro Ser Lys Arg Ser 
                805                 810                 815     


Phe Ile Glu Asp Leu Leu Phe Asn Lys Val Thr Leu Ala Asp Ala Gly 
            820                 825                 830         


Phe Ile Lys Gln Tyr Gly Asp Cys Leu Gly Asp Ile Ala Ala Arg Asp 
        835                 840                 845             


Leu Ile Cys Ala Gln Lys Phe Asn Gly Leu Thr Val Leu Pro Pro Leu 
    850                 855                 860                 


Leu Thr Asp Glu Met Ile Ala Gln Tyr Thr Ser Ala Leu Leu Ala Gly 
865                 870                 875                 880 


Thr Ile Thr Ser Gly Trp Thr Phe Gly Ala Gly Ala Ala Leu Gln Ile 
                885                 890                 895     


Pro Phe Ala Met Gln Met Ala Tyr Arg Phe Asn Gly Ile Gly Val Thr 
            900                 905                 910         


Gln Asn Val Leu Tyr Glu Asn Gln Lys Leu Ile Ala Asn Gln Phe Asn 
        915                 920                 925             


Ser Ala Ile Gly Lys Ile Gln Asp Ser Leu Ser Ser Thr Ala Ser Ala 
    930                 935                 940                 


Leu Gly Lys Leu Gln Asp Val Val Asn Gln Asn Ala Gln Ala Leu Asn 
945                 950                 955                 960 


Thr Leu Val Lys Gln Leu Ser Ser Asn Phe Gly Ala Ile Ser Ser Val 
                965                 970                 975     


Leu Asn Asp Ile Leu Ser Arg Leu Asp Pro Pro Glu Ala Glu Val Gln 
            980                 985                 990         


Ile Asp Arg Leu Ile Thr Gly Arg  Leu Gln Ser Leu Gln  Thr Tyr Val 
        995                 1000                 1005             


Thr Gln  Gln Leu Ile Arg Ala  Ala Glu Ile Arg Ala  Ser Ala Asn 
    1010                 1015                 1020             


Leu Ala  Ala Thr Lys Met Ser  Glu Cys Val Leu Gly  Gln Ser Lys 
    1025                 1030                 1035             


Arg Val  Asp Phe Cys Gly Lys  Gly Tyr His Leu Met  Ser Phe Pro 
    1040                 1045                 1050             


Gln Ser  Ala Pro His Gly Val  Val Phe Leu His Val  Thr Tyr Val 
    1055                 1060                 1065             


Pro Ala  Gln Glu Lys Asn Phe  Thr Thr Ala Pro Ala  Ile Cys His 
    1070                 1075                 1080             


Asp Gly  Lys Ala His Phe Pro  Arg Glu Gly Val Phe  Val Ser Asn 
    1085                 1090                 1095             


Gly Thr  His Trp Phe Val Thr  Gln Arg Asn Phe Tyr  Glu Pro Gln 
    1100                 1105                 1110             


Ile Ile  Thr Thr Asp Asn Thr  Phe Val Ser Gly Asn  Cys Asp Val 
    1115                 1120                 1125             


Val Ile  Gly Ile Val Asn Asn  Thr Val Tyr Asp Pro  Leu Gln Pro 
    1130                 1135                 1140             


Glu Leu  Asp Ser Phe Lys Glu  Glu Leu Asp Lys Tyr  Phe Lys Asn 
    1145                 1150                 1155             


His Thr  Ser Pro Asp Val Asp  Leu Gly Asp Ile Ser  Gly Ile Asn 
    1160                 1165                 1170             


Ala Ser  Val Val Asn Ile Gln  Lys Glu Ile Asp Arg  Leu Asn Glu 
    1175                 1180                 1185             


Val Ala  Lys Asn Leu Asn Glu  Ser Leu Ile Asp Leu  Gln Glu Leu 
    1190                 1195                 1200             


Gly Lys  Tyr Glu Gln Tyr Ile  Lys Trp Pro Trp Tyr  Ile Trp Leu 
    1205                 1210                 1215             


Gly Phe  Ile Ala Gly Leu Ile  Ala Ile Val Met Val  Thr Ile Met 
    1220                 1225                 1230             


Leu Cys  Cys Met Thr Ser Cys  Cys Ser Cys Leu Lys  Gly Cys Cys 
    1235                 1240                 1245             


Ser Cys  Gly Ser Cys Cys Lys  Phe Asp Glu Asp Asp  Ser Glu Pro 
    1250                 1255                 1260             


Val Leu  Lys Gly Val Lys Leu  His Tyr Thr 
    1265                 1270             


<210>  11
<211>  3822
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  S-(deg-RBD-1194)

<400>  11
atgttcgtct tcctggtcct gctgcctctg gtctcctcac agtgcgtcaa tctgacaact       60

cggactcagc tgccacctgc ttatactaat agcttcacca gaggcgtgta ctatcctgac      120

aaggtgttta gaagctccgt gctgcactct acacaggatc tgtttctgcc attctttagc      180

aacgtgacct ggttccacgc catccacgtg agcggcacca atggcacaaa gcggttcgac      240

aatcccgtgc tgccttttaa cgatggcgtg tacttcgcct ctaccgagaa gagcaacatc      300

atcagaggct ggatctttgg caccacactg gactccaaga cacagtctct gctgatcgtg      360

aacaatgcca ccaacgtggt catcaaggtg tgcgagttcc agttttgtaa tgatcccttc      420

ctgggcgtgt actatcacaa gaacaataag agctggatgg agtccgagtt tagagtgtat      480

tctagcgcca acaactgcac atttgagtac gtgagccagc ctttcctgat ggacctggag      540

ggcaagcagg gcaatttcaa gaacctgagg gagttcgtgt ttaagaatat cgacggctac      600

ttcaaaatct actctaagca cacccccatc aacctggtgc gcgacctgcc tcagggcttc      660

agcgccctgg agcccctggt ggatctgcct atcggcatca acatcacccg gtttcagaca      720

ctgctggccc tgcacagaag ctacctgaca cccggcgact cctctagcgg atggaccgcc      780

ggcgctgccg cctactatgt gggctacctc cagccccgga ccttcctgct gaagtacaac      840

gagaatggca ccatcacaga cgcagtggat tgcgccctgg accccctgag cgagacaaag      900

tgtacactga agtcctttac cgtggagaag ggcatctatc agacatccaa tttcagggtg      960

cagccagccg aggcgatcgt gcgctttcct gaaatcacaa acctgtgccc atttggcgag     1020

gtgttcgagg caacccgctt cgccagcgtg tacgcctgga ataggaagcg gatcagcaac     1080

tgcgtggccg actatagcgt gctgtacaac tccgcctctt tcagcacctt taagtgctat     1140

ggcgtgtccc ccacaaagct gaatgacctg tgctttacca acgtctacgc cgattctttc     1200

gtgatcaggg gcgacgaggt gcgccagatc gcccccggcc agacaggcaa gatcgcagac     1260

tacaattata agctgccaga cgatttcacc ggctgcgtga tcgcctggaa cagcaacaat     1320

ctggattcca aagtgggcgg caactacaat tatctgtacc ggctgtttag aaagagcaat     1380

ctgaagccct tcgagaggga catctctaca gaaatctacc aggccggcag caccccttgc     1440

aatggcgtgg agggctttaa ctgttatttc ccactccagt cctacggctt ccagcccaca     1500

aacggcgtgg gctatcagcc ttaccgcgtg gtggtgctga gctttgagct gctgcacgcc     1560

ccagcaacag tgtgcggccc caagaagtcc accaatctgg tgaagaacaa gtgcgtgaac     1620

ttcaacttca acggcctgac cggcacaggc gtgctgaccg agtccaacaa gaagttcctg     1680

ccatttcagc agttcggcag ggacatcgca gataccacag acgccgtgcg cgacccacag     1740

accctggaga tcctggacat cacaccctgc tctttcggcg gcgtgagcgt gatcacaccc     1800

ggcaccaata caagcaacca ggtggccgtg ctgtatcagg acgtgaattg taccgaggtg     1860

cccgtggcta tccacgccga tcagctgacc ccaacatggc gggtgtacag caccggctcc     1920

aacgtcttcc agacaagagc cggatgcctg atcggagcag agcacgtgaa caattcctat     1980

gagtgcgaca tcccaatcgg cgccggcatc tgtgcctctt accagaccca gacaaactct     2040

cccagaagag cccggagcgt ggcctcccag tctatcatcg cctataccat gtccctgggc     2100

gccgagaaca gcgtggccta ctctaacaat agcatcgcca tcccaaccaa cttcacaatc     2160

tctgtgacca cagagatcct gcccgtgtcc atgaccaaga catctgtgga ctgcacaatg     2220

tatatctgtg gcgattctac cgagtgcagc aacctgctgc tccagtacgg cagcttttgt     2280

acccagctga atagagccct gacaggcatc gccgtggagc aggataagaa cacacaggag     2340

gtgttcgccc aggtgaagca aatctacaag acccccccta tcaaggactt tggcggcttc     2400

aatttttccc agatcctgcc tgatccatcc aagccttcta agcggagctt tatcgaggac     2460

ctgctgttca acaaggtgac cctggccgat gccggcttca tcaagcagta tggcgattgc     2520

ctgggcgaca tcgcagccag ggacctgatc tgcgcccaga agtttaatgg cctgaccgtg     2580

ctgccacccc tgctgacaga tgagatgatc gcacagtaca caagcgccct gctggccggc     2640

accatcacat ccggatggac cttcggcgca ggagccgccc tccagatccc ctttgccatg     2700

cagatggcct ataggttcaa cggcatcggc gtgacccaga atgtgctgta cgagaaccag     2760

aagctgatcg ccaatcagtt taactccgcc atcggcaaga tccaggacag cctgtcctct     2820

acagccagcg ccctgggcaa gctccaggat gtggtgaatc agaacgccca ggccctgaat     2880

accctggtga agcagctgag cagcaacttc ggcgccatct ctagcgtgct gaatgacatc     2940

ctgagccggc tggacaaggt ggaggcagag gtgcagatcg accggctgat caccggccgg     3000

ctccagagcc tccagaccta tgtgacacag cagctgatca gggccgccga gatcagggcc     3060

agcgccaatc tggcagcaac caagatgtcc gagtgcgtgc tgggccagtc taagagagtg     3120

gacttttgtg gcaagggcta tcacctgatg tccttccctc agtctgcccc acacggcgtg     3180

gtgtttctgc acgtgaccta cgtgcccgcc caggagaaga acttcaccac agcccctgcc     3240

atctgccacg atggcaaggc ccactttcca agggagggcg tgttcgtgtc caacggcacc     3300

cactggtttg tgacacagcg caatttctac gagccccaga tcatcaccac agacaacacc     3360

ttcgtgagcg gcaactgtga cgtggtcatc ggcatcgtga acaataccgt gtatgatcca     3420

ctccagcccg agctggacag ctttaaggag gagctggata agtatttcaa gaatcacacc     3480

tcccctgacg tggatctggg cgacatcagc ggcatcaatg cctccgtggt gaacatccag     3540

aaggagatcg accgcctgaa cgaggtggct aagaatctgc aggagagcct gatcgacctc     3600

caggagctgg gcaagtatga gcagtacatc aagtggccct ggtacatctg gctgggcttc     3660

atcgccggcc tgatcgccat cgtgatggtg accatcatgc tgtgctgtat gacatcctgc     3720

tgttcttgcc tgaagggctg ctgtagctgt ggctcctgct gtaagtttga cgaggatgac     3780

tctgaacctg tgctgaaggg cgtgaagctg cattacacct aa                        3822


<210>  12
<211>  1273
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  S-(deg-RBD-1194)

<400>  12

Met Phe Val Phe Leu Val Leu Leu Pro Leu Val Ser Ser Gln Cys Val 
1               5                   10                  15      


Asn Leu Thr Thr Arg Thr Gln Leu Pro Pro Ala Tyr Thr Asn Ser Phe 
            20                  25                  30          


Thr Arg Gly Val Tyr Tyr Pro Asp Lys Val Phe Arg Ser Ser Val Leu 
        35                  40                  45              


His Ser Thr Gln Asp Leu Phe Leu Pro Phe Phe Ser Asn Val Thr Trp 
    50                  55                  60                  


Phe His Ala Ile His Val Ser Gly Thr Asn Gly Thr Lys Arg Phe Asp 
65                  70                  75                  80  


Asn Pro Val Leu Pro Phe Asn Asp Gly Val Tyr Phe Ala Ser Thr Glu 
                85                  90                  95      


Lys Ser Asn Ile Ile Arg Gly Trp Ile Phe Gly Thr Thr Leu Asp Ser 
            100                 105                 110         


Lys Thr Gln Ser Leu Leu Ile Val Asn Asn Ala Thr Asn Val Val Ile 
        115                 120                 125             


Lys Val Cys Glu Phe Gln Phe Cys Asn Asp Pro Phe Leu Gly Val Tyr 
    130                 135                 140                 


Tyr His Lys Asn Asn Lys Ser Trp Met Glu Ser Glu Phe Arg Val Tyr 
145                 150                 155                 160 


Ser Ser Ala Asn Asn Cys Thr Phe Glu Tyr Val Ser Gln Pro Phe Leu 
                165                 170                 175     


Met Asp Leu Glu Gly Lys Gln Gly Asn Phe Lys Asn Leu Arg Glu Phe 
            180                 185                 190         


Val Phe Lys Asn Ile Asp Gly Tyr Phe Lys Ile Tyr Ser Lys His Thr 
        195                 200                 205             


Pro Ile Asn Leu Val Arg Asp Leu Pro Gln Gly Phe Ser Ala Leu Glu 
    210                 215                 220                 


Pro Leu Val Asp Leu Pro Ile Gly Ile Asn Ile Thr Arg Phe Gln Thr 
225                 230                 235                 240 


Leu Leu Ala Leu His Arg Ser Tyr Leu Thr Pro Gly Asp Ser Ser Ser 
                245                 250                 255     


Gly Trp Thr Ala Gly Ala Ala Ala Tyr Tyr Val Gly Tyr Leu Gln Pro 
            260                 265                 270         


Arg Thr Phe Leu Leu Lys Tyr Asn Glu Asn Gly Thr Ile Thr Asp Ala 
        275                 280                 285             


Val Asp Cys Ala Leu Asp Pro Leu Ser Glu Thr Lys Cys Thr Leu Lys 
    290                 295                 300                 


Ser Phe Thr Val Glu Lys Gly Ile Tyr Gln Thr Ser Asn Phe Arg Val 
305                 310                 315                 320 


Gln Pro Ala Glu Ala Ile Val Arg Phe Pro Gln Ile Thr Asn Leu Cys 
                325                 330                 335     


Pro Phe Gly Glu Val Phe Gln Ala Thr Arg Phe Ala Ser Val Tyr Ala 
            340                 345                 350         


Trp Asn Arg Lys Arg Ile Ser Asn Cys Val Ala Asp Tyr Ser Val Leu 
        355                 360                 365             


Tyr Asn Ser Ala Ser Phe Ser Thr Phe Lys Cys Tyr Gly Val Ser Pro 
    370                 375                 380                 


Thr Lys Leu Asn Asp Leu Cys Phe Thr Asn Val Tyr Ala Asp Ser Phe 
385                 390                 395                 400 


Val Ile Arg Gly Asp Glu Val Arg Gln Ile Ala Pro Gly Gln Thr Gly 
                405                 410                 415     


Lys Ile Ala Asp Tyr Asn Tyr Lys Leu Pro Asp Asp Phe Thr Gly Cys 
            420                 425                 430         


Val Ile Ala Trp Asn Ser Asn Asn Leu Asp Ser Lys Val Gly Gly Asn 
        435                 440                 445             


Tyr Asn Tyr Leu Tyr Arg Leu Phe Arg Lys Ser Asn Leu Lys Pro Phe 
    450                 455                 460                 


Glu Arg Asp Ile Ser Thr Glu Ile Tyr Gln Ala Gly Ser Thr Pro Cys 
465                 470                 475                 480 


Asn Gly Val Glu Gly Phe Asn Cys Tyr Phe Pro Leu Gln Ser Tyr Gly 
                485                 490                 495     


Phe Gln Pro Thr Asn Gly Val Gly Tyr Gln Pro Tyr Arg Val Val Val 
            500                 505                 510         


Leu Ser Phe Glu Leu Leu His Ala Pro Ala Thr Val Cys Gly Pro Lys 
        515                 520                 525             


Lys Ser Thr Asn Leu Val Lys Asn Lys Cys Val Asn Phe Asn Phe Asn 
    530                 535                 540                 


Gly Leu Thr Gly Thr Gly Val Leu Thr Glu Ser Asn Lys Lys Phe Leu 
545                 550                 555                 560 


Pro Phe Gln Gln Phe Gly Arg Asp Ile Ala Asp Thr Thr Asp Ala Val 
                565                 570                 575     


Arg Asp Pro Gln Thr Leu Glu Ile Leu Asp Ile Thr Pro Cys Ser Phe 
            580                 585                 590         


Gly Gly Val Ser Val Ile Thr Pro Gly Thr Asn Thr Ser Asn Gln Val 
        595                 600                 605             


Ala Val Leu Tyr Gln Asp Val Asn Cys Thr Glu Val Pro Val Ala Ile 
    610                 615                 620                 


His Ala Asp Gln Leu Thr Pro Thr Trp Arg Val Tyr Ser Thr Gly Ser 
625                 630                 635                 640 


Asn Val Phe Gln Thr Arg Ala Gly Cys Leu Ile Gly Ala Glu His Val 
                645                 650                 655     


Asn Asn Ser Tyr Glu Cys Asp Ile Pro Ile Gly Ala Gly Ile Cys Ala 
            660                 665                 670         


Ser Tyr Gln Thr Gln Thr Asn Ser Pro Arg Arg Ala Arg Ser Val Ala 
        675                 680                 685             


Ser Gln Ser Ile Ile Ala Tyr Thr Met Ser Leu Gly Ala Glu Asn Ser 
    690                 695                 700                 


Val Ala Tyr Ser Asn Asn Ser Ile Ala Ile Pro Thr Asn Phe Thr Ile 
705                 710                 715                 720 


Ser Val Thr Thr Glu Ile Leu Pro Val Ser Met Thr Lys Thr Ser Val 
                725                 730                 735     


Asp Cys Thr Met Tyr Ile Cys Gly Asp Ser Thr Glu Cys Ser Asn Leu 
            740                 745                 750         


Leu Leu Gln Tyr Gly Ser Phe Cys Thr Gln Leu Asn Arg Ala Leu Thr 
        755                 760                 765             


Gly Ile Ala Val Glu Gln Asp Lys Asn Thr Gln Glu Val Phe Ala Gln 
    770                 775                 780                 


Val Lys Gln Ile Tyr Lys Thr Pro Pro Ile Lys Asp Phe Gly Gly Phe 
785                 790                 795                 800 


Asn Phe Ser Gln Ile Leu Pro Asp Pro Ser Lys Pro Ser Lys Arg Ser 
                805                 810                 815     


Phe Ile Glu Asp Leu Leu Phe Asn Lys Val Thr Leu Ala Asp Ala Gly 
            820                 825                 830         


Phe Ile Lys Gln Tyr Gly Asp Cys Leu Gly Asp Ile Ala Ala Arg Asp 
        835                 840                 845             


Leu Ile Cys Ala Gln Lys Phe Asn Gly Leu Thr Val Leu Pro Pro Leu 
    850                 855                 860                 


Leu Thr Asp Glu Met Ile Ala Gln Tyr Thr Ser Ala Leu Leu Ala Gly 
865                 870                 875                 880 


Thr Ile Thr Ser Gly Trp Thr Phe Gly Ala Gly Ala Ala Leu Gln Ile 
                885                 890                 895     


Pro Phe Ala Met Gln Met Ala Tyr Arg Phe Asn Gly Ile Gly Val Thr 
            900                 905                 910         


Gln Asn Val Leu Tyr Glu Asn Gln Lys Leu Ile Ala Asn Gln Phe Asn 
        915                 920                 925             


Ser Ala Ile Gly Lys Ile Gln Asp Ser Leu Ser Ser Thr Ala Ser Ala 
    930                 935                 940                 


Leu Gly Lys Leu Gln Asp Val Val Asn Gln Asn Ala Gln Ala Leu Asn 
945                 950                 955                 960 


Thr Leu Val Lys Gln Leu Ser Ser Asn Phe Gly Ala Ile Ser Ser Val 
                965                 970                 975     


Leu Asn Asp Ile Leu Ser Arg Leu Asp Pro Pro Glu Ala Glu Val Gln 
            980                 985                 990         


Ile Asp Arg Leu Ile Thr Gly Arg  Leu Gln Ser Leu Gln  Thr Tyr Val 
        995                 1000                 1005             


Thr Gln  Gln Leu Ile Arg Ala  Ala Glu Ile Arg Ala  Ser Ala Asn 
    1010                 1015                 1020             


Leu Ala  Ala Thr Lys Met Ser  Glu Cys Val Leu Gly  Gln Ser Lys 
    1025                 1030                 1035             


Arg Val  Asp Phe Cys Gly Lys  Gly Tyr His Leu Met  Ser Phe Pro 
    1040                 1045                 1050             


Gln Ser  Ala Pro His Gly Val  Val Phe Leu His Val  Thr Tyr Val 
    1055                 1060                 1065             


Pro Ala  Gln Glu Lys Asn Phe  Thr Thr Ala Pro Ala  Ile Cys His 
    1070                 1075                 1080             


Asp Gly  Lys Ala His Phe Pro  Arg Glu Gly Val Phe  Val Ser Asn 
    1085                 1090                 1095             


Gly Thr  His Trp Phe Val Thr  Gln Arg Asn Phe Tyr  Glu Pro Gln 
    1100                 1105                 1110             


Ile Ile  Thr Thr Asp Asn Thr  Phe Val Ser Gly Asn  Cys Asp Val 
    1115                 1120                 1125             


Val Ile  Gly Ile Val Asn Asn  Thr Val Tyr Asp Pro  Leu Gln Pro 
    1130                 1135                 1140             


Glu Leu  Asp Ser Phe Lys Glu  Glu Leu Asp Lys Tyr  Phe Lys Asn 
    1145                 1150                 1155             


His Thr  Ser Pro Asp Val Asp  Leu Gly Asp Ile Ser  Gly Ile Asn 
    1160                 1165                 1170             


Ala Ser  Val Val Asn Ile Gln  Lys Glu Ile Asp Arg  Leu Asn Glu 
    1175                 1180                 1185             


Val Ala  Lys Asn Leu Gln Glu  Ser Leu Ile Asp Leu  Gln Glu Leu 
    1190                 1195                 1200             


Gly Lys  Tyr Glu Gln Tyr Ile  Lys Trp Pro Trp Tyr  Ile Trp Leu 
    1205                 1210                 1215             


Gly Phe  Ile Ala Gly Leu Ile  Ala Ile Val Met Val  Thr Ile Met 
    1220                 1225                 1230             


Leu Cys  Cys Met Thr Ser Cys  Cys Ser Cys Leu Lys  Gly Cys Cys 
    1235                 1240                 1245             


Ser Cys  Gly Ser Cys Cys Lys  Phe Asp Glu Asp Asp  Ser Glu Pro 
    1250                 1255                 1260             


Val Leu  Lys Gly Val Lys Leu  His Tyr Thr 
    1265                 1270             


<210>  13
<211>  3822
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  S-(deg-RBD-122-165-234)

<400>  13
atgttcgtct tcctggtcct gctgcctctg gtctcctcac agtgcgtcaa tctgacaact       60

cggactcagc tgccacctgc ttatactaat agcttcacca gaggcgtgta ctatcctgac      120

aaggtgttta gaagctccgt gctgcactct acacaggatc tgtttctgcc attctttagc      180

aacgtgacct ggttccacgc catccacgtg agcggcacca atggcacaaa gcggttcgac      240

aatcccgtgc tgccttttaa cgatggcgtg tacttcgcct ctaccgagaa gagcaacatc      300

atcagaggct ggatctttgg caccacactg gactccaaga cacagtctct gctgatcgtg      360

aaccaagcca ccaacgtggt catcaaggtg tgcgagttcc agttttgtaa tgatcccttc      420

ctgggcgtgt actatcacaa gaacaataag agctggatgg agtccgagtt tagagtgtat      480

tctagcgcca accagtgcac atttgagtac gtgagccagc ctttcctgat ggacctggag      540

ggcaagcagg gcaatttcaa gaacctgagg gagttcgtgt ttaagaatat cgacggctac      600

ttcaaaatct actctaagca cacccccatc aacctggtgc gcgacctgcc tcagggcttc      660

agcgccctgg agcccctggt ggatctgcct atcggcatcc agatcacccg gtttcagaca      720

ctgctggccc tgcacagaag ctacctgaca cccggcgact cctctagcgg atggaccgcc      780

ggcgctgccg cctactatgt gggctacctc cagccccgga ccttcctgct gaagtacaac      840

gagaatggca ccatcacaga cgcagtggat tgcgccctgg accccctgag cgagacaaag      900

tgtacactga agtcctttac cgtggagaag ggcatctatc agacatccaa tttcagggtg      960

cagccagccg aggcgatcgt gcgctttcct gaaatcacaa acctgtgccc atttggcgag     1020

gtgttcgagg caacccgctt cgccagcgtg tacgcctgga ataggaagcg gatcagcaac     1080

tgcgtggccg actatagcgt gctgtacaac tccgcctctt tcagcacctt taagtgctat     1140

ggcgtgtccc ccacaaagct gaatgacctg tgctttacca acgtctacgc cgattctttc     1200

gtgatcaggg gcgacgaggt gcgccagatc gcccccggcc agacaggcaa gatcgcagac     1260

tacaattata agctgccaga cgatttcacc ggctgcgtga tcgcctggaa cagcaacaat     1320

ctggattcca aagtgggcgg caactacaat tatctgtacc ggctgtttag aaagagcaat     1380

ctgaagccct tcgagaggga catctctaca gaaatctacc aggccggcag caccccttgc     1440

aatggcgtgg agggctttaa ctgttatttc ccactccagt cctacggctt ccagcccaca     1500

aacggcgtgg gctatcagcc ttaccgcgtg gtggtgctga gctttgagct gctgcacgcc     1560

ccagcaacag tgtgcggccc caagaagtcc accaatctgg tgaagaacaa gtgcgtgaac     1620

ttcaacttca acggcctgac cggcacaggc gtgctgaccg agtccaacaa gaagttcctg     1680

ccatttcagc agttcggcag ggacatcgca gataccacag acgccgtgcg cgacccacag     1740

accctggaga tcctggacat cacaccctgc tctttcggcg gcgtgagcgt gatcacaccc     1800

ggcaccaata caagcaacca ggtggccgtg ctgtatcagg acgtgaattg taccgaggtg     1860

cccgtggcta tccacgccga tcagctgacc ccaacatggc gggtgtacag caccggctcc     1920

aacgtcttcc agacaagagc cggatgcctg atcggagcag agcacgtgaa caattcctat     1980

gagtgcgaca tcccaatcgg cgccggcatc tgtgcctctt accagaccca gacaaactct     2040

cccagaagag cccggagcgt ggcctcccag tctatcatcg cctataccat gtccctgggc     2100

gccgagaaca gcgtggccta ctctaacaat agcatcgcca tcccaaccaa cttcacaatc     2160

tctgtgacca cagagatcct gcccgtgtcc atgaccaaga catctgtgga ctgcacaatg     2220

tatatctgtg gcgattctac cgagtgcagc aacctgctgc tccagtacgg cagcttttgt     2280

acccagctga atagagccct gacaggcatc gccgtggagc aggataagaa cacacaggag     2340

gtgttcgccc aggtgaagca aatctacaag acccccccta tcaaggactt tggcggcttc     2400

aatttttccc agatcctgcc tgatccatcc aagccttcta agcggagctt tatcgaggac     2460

ctgctgttca acaaggtgac cctggccgat gccggcttca tcaagcagta tggcgattgc     2520

ctgggcgaca tcgcagccag ggacctgatc tgcgcccaga agtttaatgg cctgaccgtg     2580

ctgccacccc tgctgacaga tgagatgatc gcacagtaca caagcgccct gctggccggc     2640

accatcacat ccggatggac cttcggcgca ggagccgccc tccagatccc ctttgccatg     2700

cagatggcct ataggttcaa cggcatcggc gtgacccaga atgtgctgta cgagaaccag     2760

aagctgatcg ccaatcagtt taactccgcc atcggcaaga tccaggacag cctgtcctct     2820

acagccagcg ccctgggcaa gctccaggat gtggtgaatc agaacgccca ggccctgaat     2880

accctggtga agcagctgag cagcaacttc ggcgccatct ctagcgtgct gaatgacatc     2940

ctgagccggc tggacaaggt ggaggcagag gtgcagatcg accggctgat caccggccgg     3000

ctccagagcc tccagaccta tgtgacacag cagctgatca gggccgccga gatcagggcc     3060

agcgccaatc tggcagcaac caagatgtcc gagtgcgtgc tgggccagtc taagagagtg     3120

gacttttgtg gcaagggcta tcacctgatg tccttccctc agtctgcccc acacggcgtg     3180

gtgtttctgc acgtgaccta cgtgcccgcc caggagaaga acttcaccac agcccctgcc     3240

atctgccacg atggcaaggc ccactttcca agggagggcg tgttcgtgtc caacggcacc     3300

cactggtttg tgacacagcg caatttctac gagccccaga tcatcaccac agacaacacc     3360

ttcgtgagcg gcaactgtga cgtggtcatc ggcatcgtga acaataccgt gtatgatcca     3420

ctccagcccg agctggacag ctttaaggag gagctggata agtatttcaa gaatcacacc     3480

tcccctgacg tggatctggg cgacatcagc ggcatcaatg cctccgtggt gaacatccag     3540

aaggagatcg accgcctgaa cgaggtggct aagaatctga acgagagcct gatcgacctc     3600

caggagctgg gcaagtatga gcagtacatc aagtggccct ggtacatctg gctgggcttc     3660

atcgccggcc tgatcgccat cgtgatggtg accatcatgc tgtgctgtat gacatcctgc     3720

tgttcttgcc tgaagggctg ctgtagctgt ggctcctgct gtaagtttga cgaggatgac     3780

tctgaacctg tgctgaaggg cgtgaagctg cattacacct aa                        3822


<210>  14
<211>  1273
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  S-(deg-RBD-122-165-234)

<400>  14

Met Phe Val Phe Leu Val Leu Leu Pro Leu Val Ser Ser Gln Cys Val 
1               5                   10                  15      


Asn Leu Thr Thr Arg Thr Gln Leu Pro Pro Ala Tyr Thr Asn Ser Phe 
            20                  25                  30          


Thr Arg Gly Val Tyr Tyr Pro Asp Lys Val Phe Arg Ser Ser Val Leu 
        35                  40                  45              


His Ser Thr Gln Asp Leu Phe Leu Pro Phe Phe Ser Asn Val Thr Trp 
    50                  55                  60                  


Phe His Ala Ile His Val Ser Gly Thr Asn Gly Thr Lys Arg Phe Asp 
65                  70                  75                  80  


Asn Pro Val Leu Pro Phe Asn Asp Gly Val Tyr Phe Ala Ser Thr Glu 
                85                  90                  95      


Lys Ser Asn Ile Ile Arg Gly Trp Ile Phe Gly Thr Thr Leu Asp Ser 
            100                 105                 110         


Lys Thr Gln Ser Leu Leu Ile Val Asn Gln Ala Thr Asn Val Val Ile 
        115                 120                 125             


Lys Val Cys Glu Phe Gln Phe Cys Asn Asp Pro Phe Leu Gly Val Tyr 
    130                 135                 140                 


Tyr His Lys Asn Asn Lys Ser Trp Met Glu Ser Glu Phe Arg Val Tyr 
145                 150                 155                 160 


Ser Ser Ala Asn Gln Cys Thr Phe Glu Tyr Val Ser Gln Pro Phe Leu 
                165                 170                 175     


Met Asp Leu Glu Gly Lys Gln Gly Asn Phe Lys Asn Leu Arg Glu Phe 
            180                 185                 190         


Val Phe Lys Asn Ile Asp Gly Tyr Phe Lys Ile Tyr Ser Lys His Thr 
        195                 200                 205             


Pro Ile Asn Leu Val Arg Asp Leu Pro Gln Gly Phe Ser Ala Leu Glu 
    210                 215                 220                 


Pro Leu Val Asp Leu Pro Ile Gly Ile Gln Ile Thr Arg Phe Gln Thr 
225                 230                 235                 240 


Leu Leu Ala Leu His Arg Ser Tyr Leu Thr Pro Gly Asp Ser Ser Ser 
                245                 250                 255     


Gly Trp Thr Ala Gly Ala Ala Ala Tyr Tyr Val Gly Tyr Leu Gln Pro 
            260                 265                 270         


Arg Thr Phe Leu Leu Lys Tyr Asn Glu Asn Gly Thr Ile Thr Asp Ala 
        275                 280                 285             


Val Asp Cys Ala Leu Asp Pro Leu Ser Glu Thr Lys Cys Thr Leu Lys 
    290                 295                 300                 


Ser Phe Thr Val Glu Lys Gly Ile Tyr Gln Thr Ser Asn Phe Arg Val 
305                 310                 315                 320 


Gln Pro Ala Glu Ala Ile Val Arg Phe Pro Gln Ile Thr Asn Leu Cys 
                325                 330                 335     


Pro Phe Gly Glu Val Phe Gln Ala Thr Arg Phe Ala Ser Val Tyr Ala 
            340                 345                 350         


Trp Asn Arg Lys Arg Ile Ser Asn Cys Val Ala Asp Tyr Ser Val Leu 
        355                 360                 365             


Tyr Asn Ser Ala Ser Phe Ser Thr Phe Lys Cys Tyr Gly Val Ser Pro 
    370                 375                 380                 


Thr Lys Leu Asn Asp Leu Cys Phe Thr Asn Val Tyr Ala Asp Ser Phe 
385                 390                 395                 400 


Val Ile Arg Gly Asp Glu Val Arg Gln Ile Ala Pro Gly Gln Thr Gly 
                405                 410                 415     


Lys Ile Ala Asp Tyr Asn Tyr Lys Leu Pro Asp Asp Phe Thr Gly Cys 
            420                 425                 430         


Val Ile Ala Trp Asn Ser Asn Asn Leu Asp Ser Lys Val Gly Gly Asn 
        435                 440                 445             


Tyr Asn Tyr Leu Tyr Arg Leu Phe Arg Lys Ser Asn Leu Lys Pro Phe 
    450                 455                 460                 


Glu Arg Asp Ile Ser Thr Glu Ile Tyr Gln Ala Gly Ser Thr Pro Cys 
465                 470                 475                 480 


Asn Gly Val Glu Gly Phe Asn Cys Tyr Phe Pro Leu Gln Ser Tyr Gly 
                485                 490                 495     


Phe Gln Pro Thr Asn Gly Val Gly Tyr Gln Pro Tyr Arg Val Val Val 
            500                 505                 510         


Leu Ser Phe Glu Leu Leu His Ala Pro Ala Thr Val Cys Gly Pro Lys 
        515                 520                 525             


Lys Ser Thr Asn Leu Val Lys Asn Lys Cys Val Asn Phe Asn Phe Asn 
    530                 535                 540                 


Gly Leu Thr Gly Thr Gly Val Leu Thr Glu Ser Asn Lys Lys Phe Leu 
545                 550                 555                 560 


Pro Phe Gln Gln Phe Gly Arg Asp Ile Ala Asp Thr Thr Asp Ala Val 
                565                 570                 575     


Arg Asp Pro Gln Thr Leu Glu Ile Leu Asp Ile Thr Pro Cys Ser Phe 
            580                 585                 590         


Gly Gly Val Ser Val Ile Thr Pro Gly Thr Asn Thr Ser Asn Gln Val 
        595                 600                 605             


Ala Val Leu Tyr Gln Asp Val Asn Cys Thr Glu Val Pro Val Ala Ile 
    610                 615                 620                 


His Ala Asp Gln Leu Thr Pro Thr Trp Arg Val Tyr Ser Thr Gly Ser 
625                 630                 635                 640 


Asn Val Phe Gln Thr Arg Ala Gly Cys Leu Ile Gly Ala Glu His Val 
                645                 650                 655     


Asn Asn Ser Tyr Glu Cys Asp Ile Pro Ile Gly Ala Gly Ile Cys Ala 
            660                 665                 670         


Ser Tyr Gln Thr Gln Thr Asn Ser Pro Arg Arg Ala Arg Ser Val Ala 
        675                 680                 685             


Ser Gln Ser Ile Ile Ala Tyr Thr Met Ser Leu Gly Ala Glu Asn Ser 
    690                 695                 700                 


Val Ala Tyr Ser Asn Asn Ser Ile Ala Ile Pro Thr Asn Phe Thr Ile 
705                 710                 715                 720 


Ser Val Thr Thr Glu Ile Leu Pro Val Ser Met Thr Lys Thr Ser Val 
                725                 730                 735     


Asp Cys Thr Met Tyr Ile Cys Gly Asp Ser Thr Glu Cys Ser Asn Leu 
            740                 745                 750         


Leu Leu Gln Tyr Gly Ser Phe Cys Thr Gln Leu Asn Arg Ala Leu Thr 
        755                 760                 765             


Gly Ile Ala Val Glu Gln Asp Lys Asn Thr Gln Glu Val Phe Ala Gln 
    770                 775                 780                 


Val Lys Gln Ile Tyr Lys Thr Pro Pro Ile Lys Asp Phe Gly Gly Phe 
785                 790                 795                 800 


Asn Phe Ser Gln Ile Leu Pro Asp Pro Ser Lys Pro Ser Lys Arg Ser 
                805                 810                 815     


Phe Ile Glu Asp Leu Leu Phe Asn Lys Val Thr Leu Ala Asp Ala Gly 
            820                 825                 830         


Phe Ile Lys Gln Tyr Gly Asp Cys Leu Gly Asp Ile Ala Ala Arg Asp 
        835                 840                 845             


Leu Ile Cys Ala Gln Lys Phe Asn Gly Leu Thr Val Leu Pro Pro Leu 
    850                 855                 860                 


Leu Thr Asp Glu Met Ile Ala Gln Tyr Thr Ser Ala Leu Leu Ala Gly 
865                 870                 875                 880 


Thr Ile Thr Ser Gly Trp Thr Phe Gly Ala Gly Ala Ala Leu Gln Ile 
                885                 890                 895     


Pro Phe Ala Met Gln Met Ala Tyr Arg Phe Asn Gly Ile Gly Val Thr 
            900                 905                 910         


Gln Asn Val Leu Tyr Glu Asn Gln Lys Leu Ile Ala Asn Gln Phe Asn 
        915                 920                 925             


Ser Ala Ile Gly Lys Ile Gln Asp Ser Leu Ser Ser Thr Ala Ser Ala 
    930                 935                 940                 


Leu Gly Lys Leu Gln Asp Val Val Asn Gln Asn Ala Gln Ala Leu Asn 
945                 950                 955                 960 


Thr Leu Val Lys Gln Leu Ser Ser Asn Phe Gly Ala Ile Ser Ser Val 
                965                 970                 975     


Leu Asn Asp Ile Leu Ser Arg Leu Asp Pro Pro Glu Ala Glu Val Gln 
            980                 985                 990         


Ile Asp Arg Leu Ile Thr Gly Arg  Leu Gln Ser Leu Gln  Thr Tyr Val 
        995                 1000                 1005             


Thr Gln  Gln Leu Ile Arg Ala  Ala Glu Ile Arg Ala  Ser Ala Asn 
    1010                 1015                 1020             


Leu Ala  Ala Thr Lys Met Ser  Glu Cys Val Leu Gly  Gln Ser Lys 
    1025                 1030                 1035             


Arg Val  Asp Phe Cys Gly Lys  Gly Tyr His Leu Met  Ser Phe Pro 
    1040                 1045                 1050             


Gln Ser  Ala Pro His Gly Val  Val Phe Leu His Val  Thr Tyr Val 
    1055                 1060                 1065             


Pro Ala  Gln Glu Lys Asn Phe  Thr Thr Ala Pro Ala  Ile Cys His 
    1070                 1075                 1080             


Asp Gly  Lys Ala His Phe Pro  Arg Glu Gly Val Phe  Val Ser Asn 
    1085                 1090                 1095             


Gly Thr  His Trp Phe Val Thr  Gln Arg Asn Phe Tyr  Glu Pro Gln 
    1100                 1105                 1110             


Ile Ile  Thr Thr Asp Asn Thr  Phe Val Ser Gly Asn  Cys Asp Val 
    1115                 1120                 1125             


Val Ile  Gly Ile Val Asn Asn  Thr Val Tyr Asp Pro  Leu Gln Pro 
    1130                 1135                 1140             


Glu Leu  Asp Ser Phe Lys Glu  Glu Leu Asp Lys Tyr  Phe Lys Asn 
    1145                 1150                 1155             


His Thr  Ser Pro Asp Val Asp  Leu Gly Asp Ile Ser  Gly Ile Asn 
    1160                 1165                 1170             


Ala Ser  Val Val Asn Ile Gln  Lys Glu Ile Asp Arg  Leu Asn Glu 
    1175                 1180                 1185             


Val Ala  Lys Asn Leu Asn Glu  Ser Leu Ile Asp Leu  Gln Glu Leu 
    1190                 1195                 1200             


Gly Lys  Tyr Glu Gln Tyr Ile  Lys Trp Pro Trp Tyr  Ile Trp Leu 
    1205                 1210                 1215             


Gly Phe  Ile Ala Gly Leu Ile  Ala Ile Val Met Val  Thr Ile Met 
    1220                 1225                 1230             


Leu Cys  Cys Met Thr Ser Cys  Cys Ser Cys Leu Lys  Gly Cys Cys 
    1235                 1240                 1245             


Ser Cys  Gly Ser Cys Cys Lys  Phe Asp Glu Asp Asp  Ser Glu Pro 
    1250                 1255                 1260             


Val Leu  Lys Gly Val Lys Leu  His Tyr Thr 
    1265                 1270             


<210>  15
<211>  3816
<212>  DNA
<213>  SARS-CoV-2 (Delta strain)

<400>  15
atgttcgtct tcctggtcct gctgcctctg gtctcctcac agtgcgtcaa tctgcgaact       60

cggactcagc tgccacctgc ttatactaat agcttcacca gaggcgtgta ctatcctgac      120

aaggtgttta gaagctccgt gctgcactct acacaggatc tgtttctgcc attctttagc      180

aacgtgacct ggttccacgc catccacgtg agcggcacca atggcacaaa gcggttcgac      240

aatcccgtgc tgccttttaa cgatggcgtg tacttcgcct ctatcgagaa gagcaacatc      300

atcagaggct ggatctttgg caccacactg gactccaaga cacagtctct gctgatcgtg      360

aacaatgcca ccaacgtggt catcaaggtg tgcgagttcc agttttgtaa tgatcccttc      420

ctggacgtgt actatcacaa gaacaataag agctggatgg agtccggagt gtattctagc      480

gccaacaact gcacatttga gtacgtgagc cagcctttcc tgatggacct ggagggcaag      540

cagggcaatt tcaagaacct gagggagttc gtgtttaaga atatcgacgg ctacttcaaa      600

atctactcta agcacacccc catcaacctg gtgcgcgacc tgcctcaggg cttcagcgcc      660

ctggagcccc tggtggatct gcctatcggc atcaacatca cccggtttca gacactgctg      720

gccctgcaca gaagctacct gacacccggc gactcctcta gcggatggac cgccggcgct      780

gccgcctact atgtgggcta cctccagccc cggaccttcc tgctgaagta caacgagaat      840

ggcaccatca cagacgcagt ggattgcgcc ctggaccccc tgagcgagac aaagtgtaca      900

ctgaagtcct ttaccgtgga gaagggcatc tatcagacat ccaatttcag ggtgcagcca      960

accgagtcta tcgtgcgctt tcctaatatc acaaacctgt gcccatttgg cgaggtgttc     1020

aacgcaaccc gcttcgccag cgtgtacgcc tggaatagga agcggatcag caactgcgtg     1080

gccgactata gcgtgctgta caactccgcc tctttcagca cctttaagtg ctatggcgtg     1140

tcccccacaa agctgaatga cctgtgcttt accaacgtct acgccgattc tttcgtgatc     1200

aggggcgacg aggtgcgcca gatcgccccc ggccagacag gcaagatcgc agactacaat     1260

tataagctgc cagacgattt caccggctgc gtgatcgcct ggaacagcaa caatctggat     1320

tccaaagtgg gcggcaacta caattatcgg taccggctgt ttagaaagag caatctgaag     1380

cccttcgaga gggacatctc tacagaaatc taccaggccg gcagcaagcc ttgcaatggc     1440

gtggagggct ttaactgtta tttcccactc cagtcctacg gcttccagcc cacaaacggc     1500

gtgggctatc agccttaccg cgtggtggtg ctgagctttg agctgctgca cgccccagca     1560

acagtgtgcg gccccaagaa gtccaccaat ctggtgaaga acaagtgcgt gaacttcaac     1620

ttcaacggcc tgaccggcac aggcgtgctg accgagtcca acaagaagtt cctgccattt     1680

cagcagttcg gcagggacat cgcagatacc acagacgccg tgcgcgaccc acagaccctg     1740

gagatcctgg acatcacacc ctgctctttc ggcggcgtga gcgtgatcac acccggcacc     1800

aatacaagca accaggtggc cgtgctgtat cagggcgtga attgtaccga ggtgcccgtg     1860

gctatccacg ccgatcagct gaccccaaca tggcgggtgt acagcaccgg ctccaacgtc     1920

ttccagacaa gagccggatg cctgatcgga gcagagcacg tgaacaattc ctatgagtgc     1980

gacatcccaa tcggcgccgg catctgtgcc tcttaccaga cccagacaaa ctctcgcaga     2040

agagcccgga gcgtggcctc ccagtctatc atcgcctata ccatgtccct gggcgccgag     2100

aacagcgtgg cctactctaa caatagcatc gccatcccaa ccaacttcac aatctctgtg     2160

accacagaga tcctgcccgt gtccatgacc aagacatctg tggactgcac aatgtatatc     2220

tgtggcgatt ctaccgagtg cagcaacctg ctgctccagt acggcagctt ttgtacccag     2280

ctgaatagag ccctgacagg catcgccgtg gagcaggata agaacacaca ggaggtgttc     2340

gcccaggtga agcaaatcta caagaccccc cctatcaagg actttggcgg cttcaatttt     2400

tcccagatcc tgcctgatcc atccaagcct tctaagcgga gctttatcga ggacctgctg     2460

ttcaacaagg tgaccctggc cgatgccggc ttcatcaagc agtatggcga ttgcctgggc     2520

gacatcgcag ccagggacct gatctgcgcc cagaagttta atggcctgac cgtgctgcca     2580

cccctgctga cagatgagat gatcgcacag tacacaagcg ccctgctggc cggcaccatc     2640

acatccggat ggaccttcgg cgcaggagcc gccctccaga tcccctttgc catgcagatg     2700

gcctataggt tcaacggcat cggcgtgacc cagaatgtgc tgtacgagaa ccagaagctg     2760

atcgccaatc agtttaactc cgccatcggc aagatccagg acagcctgtc ctctacagcc     2820

agcgccctgg gcaagctcca gaatgtggtg aatcagaacg cccaggccct gaataccctg     2880

gtgaagcagc tgagcagcaa cttcggcgcc atctctagcg tgctgaatga catcctgagc     2940

cggctggaca aggtggaggc agaggtgcag atcgaccggc tgatcaccgg ccggctccag     3000

agcctccaga cctatgtgac acagcagctg atcagggccg ccgagatcag ggccagcgcc     3060

aatctggcag caaccaagat gtccgagtgc gtgctgggcc agtctaagag agtggacttt     3120

tgtggcaagg gctatcacct gatgtccttc cctcagtctg ccccacacgg cgtggtgttt     3180

ctgcacgtga cctacgtgcc cgcccaggag aagaacttca ccacagcccc tgccatctgc     3240

cacgatggca aggcccactt tccaagggag ggcgtgttcg tgtccaacgg cacccactgg     3300

tttgtgacac agcgcaattt ctacgagccc cagatcatca ccacagacaa caccttcgtg     3360

agcggcaact gtgacgtggt catcggcatc gtgaacaata ccgtgtatga tccactccag     3420

cccgagctgg acagctttaa ggaggagctg gataagtatt tcaagaatca cacctcccct     3480

gacgtggatc tgggcgacat cagcggcatc aatgcctccg tggtgaacat ccagaaggag     3540

atcgaccgcc tgaacgaggt ggctaagaat ctgaacgaga gcctgatcga cctccaggag     3600

ctgggcaagt atgagcagta catcaagtgg ccctggtaca tctggctggg cttcatcgcc     3660

ggcctgatcg ccatcgtgat ggtgaccatc atgctgtgct gtatgacatc ctgctgttct     3720

tgcctgaagg gctgctgtag ctgtggctcc tgctgtaagt ttgacgagga tgactctgaa     3780

cctgtgctga agggcgtgaa gctgcattac acctaa                               3816


<210>  16
<211>  1271
<212>  PRT
<213>  SARS-CoV-2 (Delta strain)

<400>  16

Met Phe Val Phe Leu Val Leu Leu Pro Leu Val Ser Ser Gln Cys Val 
1               5                   10                  15      


Asn Leu Arg Thr Arg Thr Gln Leu Pro Pro Ala Tyr Thr Asn Ser Phe 
            20                  25                  30          


Thr Arg Gly Val Tyr Tyr Pro Asp Lys Val Phe Arg Ser Ser Val Leu 
        35                  40                  45              


His Ser Thr Gln Asp Leu Phe Leu Pro Phe Phe Ser Asn Val Thr Trp 
    50                  55                  60                  


Phe His Ala Ile His Val Ser Gly Thr Asn Gly Thr Lys Arg Phe Asp 
65                  70                  75                  80  


Asn Pro Val Leu Pro Phe Asn Asp Gly Val Tyr Phe Ala Ser Ile Glu 
                85                  90                  95      


Lys Ser Asn Ile Ile Arg Gly Trp Ile Phe Gly Thr Thr Leu Asp Ser 
            100                 105                 110         


Lys Thr Gln Ser Leu Leu Ile Val Asn Asn Ala Thr Asn Val Val Ile 
        115                 120                 125             


Lys Val Cys Glu Phe Gln Phe Cys Asn Asp Pro Phe Leu Asp Val Tyr 
    130                 135                 140                 


Tyr His Lys Asn Asn Lys Ser Trp Met Glu Ser Gly Val Tyr Ser Ser 
145                 150                 155                 160 


Ala Asn Asn Cys Thr Phe Glu Tyr Val Ser Gln Pro Phe Leu Met Asp 
                165                 170                 175     


Leu Glu Gly Lys Gln Gly Asn Phe Lys Asn Leu Arg Glu Phe Val Phe 
            180                 185                 190         


Lys Asn Ile Asp Gly Tyr Phe Lys Ile Tyr Ser Lys His Thr Pro Ile 
        195                 200                 205             


Asn Leu Val Arg Asp Leu Pro Gln Gly Phe Ser Ala Leu Glu Pro Leu 
    210                 215                 220                 


Val Asp Leu Pro Ile Gly Ile Asn Ile Thr Arg Phe Gln Thr Leu Leu 
225                 230                 235                 240 


Ala Leu His Arg Ser Tyr Leu Thr Pro Gly Asp Ser Ser Ser Gly Trp 
                245                 250                 255     


Thr Ala Gly Ala Ala Ala Tyr Tyr Val Gly Tyr Leu Gln Pro Arg Thr 
            260                 265                 270         


Phe Leu Leu Lys Tyr Asn Glu Asn Gly Thr Ile Thr Asp Ala Val Asp 
        275                 280                 285             


Cys Ala Leu Asp Pro Leu Ser Glu Thr Lys Cys Thr Leu Lys Ser Phe 
    290                 295                 300                 


Thr Val Glu Lys Gly Ile Tyr Gln Thr Ser Asn Phe Arg Val Gln Pro 
305                 310                 315                 320 


Thr Glu Ser Ile Val Arg Phe Pro Asn Ile Thr Asn Leu Cys Pro Phe 
                325                 330                 335     


Gly Glu Val Phe Asn Ala Thr Arg Phe Ala Ser Val Tyr Ala Trp Asn 
            340                 345                 350         


Arg Lys Arg Ile Ser Asn Cys Val Ala Asp Tyr Ser Val Leu Tyr Asn 
        355                 360                 365             


Ser Ala Ser Phe Ser Thr Phe Lys Cys Tyr Gly Val Ser Pro Thr Lys 
    370                 375                 380                 


Leu Asn Asp Leu Cys Phe Thr Asn Val Tyr Ala Asp Ser Phe Val Ile 
385                 390                 395                 400 


Arg Gly Asp Glu Val Arg Gln Ile Ala Pro Gly Gln Thr Gly Lys Ile 
                405                 410                 415     


Ala Asp Tyr Asn Tyr Lys Leu Pro Asp Asp Phe Thr Gly Cys Val Ile 
            420                 425                 430         


Ala Trp Asn Ser Asn Asn Leu Asp Ser Lys Val Gly Gly Asn Tyr Asn 
        435                 440                 445             


Tyr Arg Tyr Arg Leu Phe Arg Lys Ser Asn Leu Lys Pro Phe Glu Arg 
    450                 455                 460                 


Asp Ile Ser Thr Glu Ile Tyr Gln Ala Gly Ser Lys Pro Cys Asn Gly 
465                 470                 475                 480 


Val Glu Gly Phe Asn Cys Tyr Phe Pro Leu Gln Ser Tyr Gly Phe Gln 
                485                 490                 495     


Pro Thr Asn Gly Val Gly Tyr Gln Pro Tyr Arg Val Val Val Leu Ser 
            500                 505                 510         


Phe Glu Leu Leu His Ala Pro Ala Thr Val Cys Gly Pro Lys Lys Ser 
        515                 520                 525             


Thr Asn Leu Val Lys Asn Lys Cys Val Asn Phe Asn Phe Asn Gly Leu 
    530                 535                 540                 


Thr Gly Thr Gly Val Leu Thr Glu Ser Asn Lys Lys Phe Leu Pro Phe 
545                 550                 555                 560 


Gln Gln Phe Gly Arg Asp Ile Ala Asp Thr Thr Asp Ala Val Arg Asp 
                565                 570                 575     


Pro Gln Thr Leu Glu Ile Leu Asp Ile Thr Pro Cys Ser Phe Gly Gly 
            580                 585                 590         


Val Ser Val Ile Thr Pro Gly Thr Asn Thr Ser Asn Gln Val Ala Val 
        595                 600                 605             


Leu Tyr Gln Gly Val Asn Cys Thr Glu Val Pro Val Ala Ile His Ala 
    610                 615                 620                 


Asp Gln Leu Thr Pro Thr Trp Arg Val Tyr Ser Thr Gly Ser Asn Val 
625                 630                 635                 640 


Phe Gln Thr Arg Ala Gly Cys Leu Ile Gly Ala Glu His Val Asn Asn 
                645                 650                 655     


Ser Tyr Glu Cys Asp Ile Pro Ile Gly Ala Gly Ile Cys Ala Ser Tyr 
            660                 665                 670         


Gln Thr Gln Thr Asn Ser Arg Arg Arg Ala Arg Ser Val Ala Ser Gln 
        675                 680                 685             


Ser Ile Ile Ala Tyr Thr Met Ser Leu Gly Ala Glu Asn Ser Val Ala 
    690                 695                 700                 


Tyr Ser Asn Asn Ser Ile Ala Ile Pro Thr Asn Phe Thr Ile Ser Val 
705                 710                 715                 720 


Thr Thr Glu Ile Leu Pro Val Ser Met Thr Lys Thr Ser Val Asp Cys 
                725                 730                 735     


Thr Met Tyr Ile Cys Gly Asp Ser Thr Glu Cys Ser Asn Leu Leu Leu 
            740                 745                 750         


Gln Tyr Gly Ser Phe Cys Thr Gln Leu Asn Arg Ala Leu Thr Gly Ile 
        755                 760                 765             


Ala Val Glu Gln Asp Lys Asn Thr Gln Glu Val Phe Ala Gln Val Lys 
    770                 775                 780                 


Gln Ile Tyr Lys Thr Pro Pro Ile Lys Asp Phe Gly Gly Phe Asn Phe 
785                 790                 795                 800 


Ser Gln Ile Leu Pro Asp Pro Ser Lys Pro Ser Lys Arg Ser Phe Ile 
                805                 810                 815     


Glu Asp Leu Leu Phe Asn Lys Val Thr Leu Ala Asp Ala Gly Phe Ile 
            820                 825                 830         


Lys Gln Tyr Gly Asp Cys Leu Gly Asp Ile Ala Ala Arg Asp Leu Ile 
        835                 840                 845             


Cys Ala Gln Lys Phe Asn Gly Leu Thr Val Leu Pro Pro Leu Leu Thr 
    850                 855                 860                 


Asp Glu Met Ile Ala Gln Tyr Thr Ser Ala Leu Leu Ala Gly Thr Ile 
865                 870                 875                 880 


Thr Ser Gly Trp Thr Phe Gly Ala Gly Ala Ala Leu Gln Ile Pro Phe 
                885                 890                 895     


Ala Met Gln Met Ala Tyr Arg Phe Asn Gly Ile Gly Val Thr Gln Asn 
            900                 905                 910         


Val Leu Tyr Glu Asn Gln Lys Leu Ile Ala Asn Gln Phe Asn Ser Ala 
        915                 920                 925             


Ile Gly Lys Ile Gln Asp Ser Leu Ser Ser Thr Ala Ser Ala Leu Gly 
    930                 935                 940                 


Lys Leu Gln Asn Val Val Asn Gln Asn Ala Gln Ala Leu Asn Thr Leu 
945                 950                 955                 960 


Val Lys Gln Leu Ser Ser Asn Phe Gly Ala Ile Ser Ser Val Leu Asn 
                965                 970                 975     


Asp Ile Leu Ser Arg Leu Asp Lys Val Glu Ala Glu Val Gln Ile Asp 
            980                 985                 990         


Arg Leu Ile Thr Gly Arg Leu Gln  Ser Leu Gln Thr Tyr  Val Thr Gln 
        995                 1000                 1005             


Gln Leu  Ile Arg Ala Ala Glu  Ile Arg Ala Ser Ala  Asn Leu Ala 
    1010                 1015                 1020             


Ala Thr  Lys Met Ser Glu Cys  Val Leu Gly Gln Ser  Lys Arg Val 
    1025                 1030                 1035             


Asp Phe  Cys Gly Lys Gly Tyr  His Leu Met Ser Phe  Pro Gln Ser 
    1040                 1045                 1050             


Ala Pro  His Gly Val Val Phe  Leu His Val Thr Tyr  Val Pro Ala 
    1055                 1060                 1065             


Gln Glu  Lys Asn Phe Thr Thr  Ala Pro Ala Ile Cys  His Asp Gly 
    1070                 1075                 1080             


Lys Ala  His Phe Pro Arg Glu  Gly Val Phe Val Ser  Asn Gly Thr 
    1085                 1090                 1095             


His Trp  Phe Val Thr Gln Arg  Asn Phe Tyr Glu Pro  Gln Ile Ile 
    1100                 1105                 1110             


Thr Thr  Asp Asn Thr Phe Val  Ser Gly Asn Cys Asp  Val Val Ile 
    1115                 1120                 1125             


Gly Ile  Val Asn Asn Thr Val  Tyr Asp Pro Leu Gln  Pro Glu Leu 
    1130                 1135                 1140             


Asp Ser  Phe Lys Glu Glu Leu  Asp Lys Tyr Phe Lys  Asn His Thr 
    1145                 1150                 1155             


Ser Pro  Asp Val Asp Leu Gly  Asp Ile Ser Gly Ile  Asn Ala Ser 
    1160                 1165                 1170             


Val Val  Asn Ile Gln Lys Glu  Ile Asp Arg Leu Asn  Glu Val Ala 
    1175                 1180                 1185             


Lys Asn  Leu Asn Glu Ser Leu  Ile Asp Leu Gln Glu  Leu Gly Lys 
    1190                 1195                 1200             


Tyr Glu  Gln Tyr Ile Lys Trp  Pro Trp Tyr Ile Trp  Leu Gly Phe 
    1205                 1210                 1215             


Ile Ala  Gly Leu Ile Ala Ile  Val Met Val Thr Ile  Met Leu Cys 
    1220                 1225                 1230             


Cys Met  Thr Ser Cys Cys Ser  Cys Leu Lys Gly Cys  Cys Ser Cys 
    1235                 1240                 1245             


Gly Ser  Cys Cys Lys Phe Asp  Glu Asp Asp Ser Glu  Pro Val Leu 
    1250                 1255                 1260             


Lys Gly  Val Lys Leu His Tyr  Thr 
    1265                 1270     


<210>  17
<211>  3822
<212>  DNA
<213>  SARS-CoV-2 (Wuhan strain S-2P strain)

<400>  17
atgttcgtct tcctggtcct gctgcctctg gtctcctcac agtgcgtcaa tctgacaact       60

cggactcagc tgccacctgc ttatactaat agcttcacca gaggcgtgta ctatcctgac      120

aaggtgttta gaagctccgt gctgcactct acacaggatc tgtttctgcc attctttagc      180

aacgtgacct ggttccacgc catccacgtg agcggcacca atggcacaaa gcggttcgac      240

aatcccgtgc tgccttttaa cgatggcgtg tacttcgcct ctaccgagaa gagcaacatc      300

atcagaggct ggatctttgg caccacactg gactccaaga cacagtctct gctgatcgtg      360

aacaatgcca ccaacgtggt catcaaggtg tgcgagttcc agttttgtaa tgatcccttc      420

ctgggcgtgt actatcacaa gaacaataag agctggatgg agtccgagtt tagagtgtat      480

tctagcgcca acaactgcac atttgagtac gtgagccagc ctttcctgat ggacctggag      540

ggcaagcagg gcaatttcaa gaacctgagg gagttcgtgt ttaagaatat cgacggctac      600

ttcaaaatct actctaagca cacccccatc aacctggtgc gcgacctgcc tcagggcttc      660

agcgccctgg agcccctggt ggatctgcct atcggcatca acatcacccg gtttcagaca      720

ctgctggccc tgcacagaag ctacctgaca cccggcgact cctctagcgg atggaccgcc      780

ggcgctgccg cctactatgt gggctacctc cagccccgga ccttcctgct gaagtacaac      840

gagaatggca ccatcacaga cgcagtggat tgcgccctgg accccctgag cgagacaaag      900

tgtacactga agtcctttac cgtggagaag ggcatctatc agacatccaa tttcagggtg      960

cagccaaccg agtctatcgt gcgctttcct aatatcacaa acctgtgccc atttggcgag     1020

gtgttcaacg caacccgctt cgccagcgtg tacgcctgga ataggaagcg gatcagcaac     1080

tgcgtggccg actatagcgt gctgtacaac tccgcctctt tcagcacctt taagtgctat     1140

ggcgtgtccc ccacaaagct gaatgacctg tgctttacca acgtctacgc cgattctttc     1200

gtgatcaggg gcgacgaggt gcgccagatc gcccccggcc agacaggcaa gatcgcagac     1260

tacaattata agctgccaga cgatttcacc ggctgcgtga tcgcctggaa cagcaacaat     1320

ctggattcca aagtgggcgg caactacaat tatctgtacc ggctgtttag aaagagcaat     1380

ctgaagccct tcgagaggga catctctaca gaaatctacc aggccggcag caccccttgc     1440

aatggcgtgg agggctttaa ctgttatttc ccactccagt cctacggctt ccagcccaca     1500

aacggcgtgg gctatcagcc ttaccgcgtg gtggtgctga gctttgagct gctgcacgcc     1560

ccagcaacag tgtgcggccc caagaagtcc accaatctgg tgaagaacaa gtgcgtgaac     1620

ttcaacttca acggcctgac cggcacaggc gtgctgaccg agtccaacaa gaagttcctg     1680

ccatttcagc agttcggcag ggacatcgca gataccacag acgccgtgcg cgacccacag     1740

accctggaga tcctggacat cacaccctgc tctttcggcg gcgtgagcgt gatcacaccc     1800

ggcaccaata caagcaacca ggtggccgtg ctgtatcagg acgtgaattg taccgaggtg     1860

cccgtggcta tccacgccga tcagctgacc ccaacatggc gggtgtacag caccggctcc     1920

aacgtcttcc agacaagagc cggatgcctg atcggagcag agcacgtgaa caattcctat     1980

gagtgcgaca tcccaatcgg cgccggcatc tgtgcctctt accagaccca gacaaactct     2040

cccagaagag cccggagcgt ggcctcccag tctatcatcg cctataccat gtccctgggc     2100

gccgagaaca gcgtggccta ctctaacaat agcatcgcca tcccaaccaa cttcacaatc     2160

tctgtgacca cagagatcct gcccgtgtcc atgaccaaga catctgtgga ctgcacaatg     2220

tatatctgtg gcgattctac cgagtgcagc aacctgctgc tccagtacgg cagcttttgt     2280

acccagctga atagagccct gacaggcatc gccgtggagc aggataagaa cacacaggag     2340

gtgttcgccc aggtgaagca aatctacaag acccccccta tcaaggactt tggcggcttc     2400

aatttttccc agatcctgcc tgatccatcc aagccttcta agcggagctt tatcgaggac     2460

ctgctgttca acaaggtgac cctggccgat gccggcttca tcaagcagta tggcgattgc     2520

ctgggcgaca tcgcagccag ggacctgatc tgcgcccaga agtttaatgg cctgaccgtg     2580

ctgccacccc tgctgacaga tgagatgatc gcacagtaca caagcgccct gctggccggc     2640

accatcacat ccggatggac cttcggcgca ggagccgccc tccagatccc ctttgccatg     2700

cagatggcct ataggttcaa cggcatcggc gtgacccaga atgtgctgta cgagaaccag     2760

aagctgatcg ccaatcagtt taactccgcc atcggcaaga tccaggacag cctgtcctct     2820

acagccagcg ccctgggcaa gctccaggat gtggtgaatc agaacgccca ggccctgaat     2880

accctggtga agcagctgag cagcaacttc ggcgccatct ctagcgtgct gaatgacatc     2940

ctgagccggc tggacccgcc ggaggcagag gtgcagatcg accggctgat caccggccgg     3000

ctccagagcc tccagaccta tgtgacacag cagctgatca gggccgccga gatcagggcc     3060

agcgccaatc tggcagcaac caagatgtcc gagtgcgtgc tgggccagtc taagagagtg     3120

gacttttgtg gcaagggcta tcacctgatg tccttccctc agtctgcccc acacggcgtg     3180

gtgtttctgc acgtgaccta cgtgcccgcc caggagaaga acttcaccac agcccctgcc     3240

atctgccacg atggcaaggc ccactttcca agggagggcg tgttcgtgtc caacggcacc     3300

cactggtttg tgacacagcg caatttctac gagccccaga tcatcaccac agacaacacc     3360

ttcgtgagcg gcaactgtga cgtggtcatc ggcatcgtga acaataccgt gtatgatcca     3420

ctccagcccg agctggacag ctttaaggag gagctggata agtatttcaa gaatcacacc     3480

tcccctgacg tggatctggg cgacatcagc ggcatcaatg cctccgtggt gaacatccag     3540

aaggagatcg accgcctgaa cgaggtggct aagaatctga acgagagcct gatcgacctc     3600

caggagctgg gcaagtatga gcagtacatc aagtggccct ggtacatctg gctgggcttc     3660

atcgccggcc tgatcgccat cgtgatggtg accatcatgc tgtgctgtat gacatcctgc     3720

tgttcttgcc tgaagggctg ctgtagctgt ggctcctgct gtaagtttga cgaggatgac     3780

tctgaacctg tgctgaaggg cgtgaagctg cattacacct aa                        3822


<210>  18
<211>  1273
<212>  PRT
<213>  SARS-CoV-2 (Wuhan strain S-2P strain)

<400>  18

Met Phe Val Phe Leu Val Leu Leu Pro Leu Val Ser Ser Gln Cys Val 
1               5                   10                  15      


Asn Leu Thr Thr Arg Thr Gln Leu Pro Pro Ala Tyr Thr Asn Ser Phe 
            20                  25                  30          


Thr Arg Gly Val Tyr Tyr Pro Asp Lys Val Phe Arg Ser Ser Val Leu 
        35                  40                  45              


His Ser Thr Gln Asp Leu Phe Leu Pro Phe Phe Ser Asn Val Thr Trp 
    50                  55                  60                  


Phe His Ala Ile His Val Ser Gly Thr Asn Gly Thr Lys Arg Phe Asp 
65                  70                  75                  80  


Asn Pro Val Leu Pro Phe Asn Asp Gly Val Tyr Phe Ala Ser Thr Glu 
                85                  90                  95      


Lys Ser Asn Ile Ile Arg Gly Trp Ile Phe Gly Thr Thr Leu Asp Ser 
            100                 105                 110         


Lys Thr Gln Ser Leu Leu Ile Val Asn Asn Ala Thr Asn Val Val Ile 
        115                 120                 125             


Lys Val Cys Glu Phe Gln Phe Cys Asn Asp Pro Phe Leu Gly Val Tyr 
    130                 135                 140                 


Tyr His Lys Asn Asn Lys Ser Trp Met Glu Ser Glu Phe Arg Val Tyr 
145                 150                 155                 160 


Ser Ser Ala Asn Asn Cys Thr Phe Glu Tyr Val Ser Gln Pro Phe Leu 
                165                 170                 175     


Met Asp Leu Glu Gly Lys Gln Gly Asn Phe Lys Asn Leu Arg Glu Phe 
            180                 185                 190         


Val Phe Lys Asn Ile Asp Gly Tyr Phe Lys Ile Tyr Ser Lys His Thr 
        195                 200                 205             


Pro Ile Asn Leu Val Arg Asp Leu Pro Gln Gly Phe Ser Ala Leu Glu 
    210                 215                 220                 


Pro Leu Val Asp Leu Pro Ile Gly Ile Asn Ile Thr Arg Phe Gln Thr 
225                 230                 235                 240 


Leu Leu Ala Leu His Arg Ser Tyr Leu Thr Pro Gly Asp Ser Ser Ser 
                245                 250                 255     


Gly Trp Thr Ala Gly Ala Ala Ala Tyr Tyr Val Gly Tyr Leu Gln Pro 
            260                 265                 270         


Arg Thr Phe Leu Leu Lys Tyr Asn Glu Asn Gly Thr Ile Thr Asp Ala 
        275                 280                 285             


Val Asp Cys Ala Leu Asp Pro Leu Ser Glu Thr Lys Cys Thr Leu Lys 
    290                 295                 300                 


Ser Phe Thr Val Glu Lys Gly Ile Tyr Gln Thr Ser Asn Phe Arg Val 
305                 310                 315                 320 


Gln Pro Thr Glu Ser Ile Val Arg Phe Pro Asn Ile Thr Asn Leu Cys 
                325                 330                 335     


Pro Phe Gly Glu Val Phe Asn Ala Thr Arg Phe Ala Ser Val Tyr Ala 
            340                 345                 350         


Trp Asn Arg Lys Arg Ile Ser Asn Cys Val Ala Asp Tyr Ser Val Leu 
        355                 360                 365             


Tyr Asn Ser Ala Ser Phe Ser Thr Phe Lys Cys Tyr Gly Val Ser Pro 
    370                 375                 380                 


Thr Lys Leu Asn Asp Leu Cys Phe Thr Asn Val Tyr Ala Asp Ser Phe 
385                 390                 395                 400 


Val Ile Arg Gly Asp Glu Val Arg Gln Ile Ala Pro Gly Gln Thr Gly 
                405                 410                 415     


Lys Ile Ala Asp Tyr Asn Tyr Lys Leu Pro Asp Asp Phe Thr Gly Cys 
            420                 425                 430         


Val Ile Ala Trp Asn Ser Asn Asn Leu Asp Ser Lys Val Gly Gly Asn 
        435                 440                 445             


Tyr Asn Tyr Leu Tyr Arg Leu Phe Arg Lys Ser Asn Leu Lys Pro Phe 
    450                 455                 460                 


Glu Arg Asp Ile Ser Thr Glu Ile Tyr Gln Ala Gly Ser Thr Pro Cys 
465                 470                 475                 480 


Asn Gly Val Glu Gly Phe Asn Cys Tyr Phe Pro Leu Gln Ser Tyr Gly 
                485                 490                 495     


Phe Gln Pro Thr Asn Gly Val Gly Tyr Gln Pro Tyr Arg Val Val Val 
            500                 505                 510         


Leu Ser Phe Glu Leu Leu His Ala Pro Ala Thr Val Cys Gly Pro Lys 
        515                 520                 525             


Lys Ser Thr Asn Leu Val Lys Asn Lys Cys Val Asn Phe Asn Phe Asn 
    530                 535                 540                 


Gly Leu Thr Gly Thr Gly Val Leu Thr Glu Ser Asn Lys Lys Phe Leu 
545                 550                 555                 560 


Pro Phe Gln Gln Phe Gly Arg Asp Ile Ala Asp Thr Thr Asp Ala Val 
                565                 570                 575     


Arg Asp Pro Gln Thr Leu Glu Ile Leu Asp Ile Thr Pro Cys Ser Phe 
            580                 585                 590         


Gly Gly Val Ser Val Ile Thr Pro Gly Thr Asn Thr Ser Asn Gln Val 
        595                 600                 605             


Ala Val Leu Tyr Gln Asp Val Asn Cys Thr Glu Val Pro Val Ala Ile 
    610                 615                 620                 


His Ala Asp Gln Leu Thr Pro Thr Trp Arg Val Tyr Ser Thr Gly Ser 
625                 630                 635                 640 


Asn Val Phe Gln Thr Arg Ala Gly Cys Leu Ile Gly Ala Glu His Val 
                645                 650                 655     


Asn Asn Ser Tyr Glu Cys Asp Ile Pro Ile Gly Ala Gly Ile Cys Ala 
            660                 665                 670         


Ser Tyr Gln Thr Gln Thr Asn Ser Pro Arg Arg Ala Arg Ser Val Ala 
        675                 680                 685             


Ser Gln Ser Ile Ile Ala Tyr Thr Met Ser Leu Gly Ala Glu Asn Ser 
    690                 695                 700                 


Val Ala Tyr Ser Asn Asn Ser Ile Ala Ile Pro Thr Asn Phe Thr Ile 
705                 710                 715                 720 


Ser Val Thr Thr Glu Ile Leu Pro Val Ser Met Thr Lys Thr Ser Val 
                725                 730                 735     


Asp Cys Thr Met Tyr Ile Cys Gly Asp Ser Thr Glu Cys Ser Asn Leu 
            740                 745                 750         


Leu Leu Gln Tyr Gly Ser Phe Cys Thr Gln Leu Asn Arg Ala Leu Thr 
        755                 760                 765             


Gly Ile Ala Val Glu Gln Asp Lys Asn Thr Gln Glu Val Phe Ala Gln 
    770                 775                 780                 


Val Lys Gln Ile Tyr Lys Thr Pro Pro Ile Lys Asp Phe Gly Gly Phe 
785                 790                 795                 800 


Asn Phe Ser Gln Ile Leu Pro Asp Pro Ser Lys Pro Ser Lys Arg Ser 
                805                 810                 815     


Phe Ile Glu Asp Leu Leu Phe Asn Lys Val Thr Leu Ala Asp Ala Gly 
            820                 825                 830         


Phe Ile Lys Gln Tyr Gly Asp Cys Leu Gly Asp Ile Ala Ala Arg Asp 
        835                 840                 845             


Leu Ile Cys Ala Gln Lys Phe Asn Gly Leu Thr Val Leu Pro Pro Leu 
    850                 855                 860                 


Leu Thr Asp Glu Met Ile Ala Gln Tyr Thr Ser Ala Leu Leu Ala Gly 
865                 870                 875                 880 


Thr Ile Thr Ser Gly Trp Thr Phe Gly Ala Gly Ala Ala Leu Gln Ile 
                885                 890                 895     


Pro Phe Ala Met Gln Met Ala Tyr Arg Phe Asn Gly Ile Gly Val Thr 
            900                 905                 910         


Gln Asn Val Leu Tyr Glu Asn Gln Lys Leu Ile Ala Asn Gln Phe Asn 
        915                 920                 925             


Ser Ala Ile Gly Lys Ile Gln Asp Ser Leu Ser Ser Thr Ala Ser Ala 
    930                 935                 940                 


Leu Gly Lys Leu Gln Asp Val Val Asn Gln Asn Ala Gln Ala Leu Asn 
945                 950                 955                 960 


Thr Leu Val Lys Gln Leu Ser Ser Asn Phe Gly Ala Ile Ser Ser Val 
                965                 970                 975     


Leu Asn Asp Ile Leu Ser Arg Leu Asp Pro Pro Glu Ala Glu Val Gln 
            980                 985                 990         


Ile Asp Arg Leu Ile Thr Gly Arg  Leu Gln Ser Leu Gln  Thr Tyr Val 
        995                 1000                 1005             


Thr Gln  Gln Leu Ile Arg Ala  Ala Glu Ile Arg Ala  Ser Ala Asn 
    1010                 1015                 1020             


Leu Ala  Ala Thr Lys Met Ser  Glu Cys Val Leu Gly  Gln Ser Lys 
    1025                 1030                 1035             


Arg Val  Asp Phe Cys Gly Lys  Gly Tyr His Leu Met  Ser Phe Pro 
    1040                 1045                 1050             


Gln Ser  Ala Pro His Gly Val  Val Phe Leu His Val  Thr Tyr Val 
    1055                 1060                 1065             


Pro Ala  Gln Glu Lys Asn Phe  Thr Thr Ala Pro Ala  Ile Cys His 
    1070                 1075                 1080             


Asp Gly  Lys Ala His Phe Pro  Arg Glu Gly Val Phe  Val Ser Asn 
    1085                 1090                 1095             


Gly Thr  His Trp Phe Val Thr  Gln Arg Asn Phe Tyr  Glu Pro Gln 
    1100                 1105                 1110             


Ile Ile  Thr Thr Asp Asn Thr  Phe Val Ser Gly Asn  Cys Asp Val 
    1115                 1120                 1125             


Val Ile  Gly Ile Val Asn Asn  Thr Val Tyr Asp Pro  Leu Gln Pro 
    1130                 1135                 1140             


Glu Leu  Asp Ser Phe Lys Glu  Glu Leu Asp Lys Tyr  Phe Lys Asn 
    1145                 1150                 1155             


His Thr  Ser Pro Asp Val Asp  Leu Gly Asp Ile Ser  Gly Ile Asn 
    1160                 1165                 1170             


Ala Ser  Val Val Asn Ile Gln  Lys Glu Ile Asp Arg  Leu Asn Glu 
    1175                 1180                 1185             


Val Ala  Lys Asn Leu Asn Glu  Ser Leu Ile Asp Leu  Gln Glu Leu 
    1190                 1195                 1200             


Gly Lys  Tyr Glu Gln Tyr Ile  Lys Trp Pro Trp Tyr  Ile Trp Leu 
    1205                 1210                 1215             


Gly Phe  Ile Ala Gly Leu Ile  Ala Ile Val Met Val  Thr Ile Met 
    1220                 1225                 1230             


Leu Cys  Cys Met Thr Ser Cys  Cys Ser Cys Leu Lys  Gly Cys Cys 
    1235                 1240                 1245             


Ser Cys  Gly Ser Cys Cys Lys  Phe Asp Glu Asp Asp  Ser Glu Pro 
    1250                 1255                 1260             


Val Leu  Lys Gly Val Lys Leu  His Tyr Thr 
    1265                 1270             


<210>  19
<211>  3816
<212>  DNA
<213>  SARS-CoV-2 (Delta S-2P strain)

<400>  19
atgttcgtct tcctggtcct gctgcctctg gtctcctcac agtgcgtcaa tctgcgaact       60

cggactcagc tgccacctgc ttatactaat agcttcacca gaggcgtgta ctatcctgac      120

aaggtgttta gaagctccgt gctgcactct acacaggatc tgtttctgcc attctttagc      180

aacgtgacct ggttccacgc catccacgtg agcggcacca atggcacaaa gcggttcgac      240

aatcccgtgc tgccttttaa cgatggcgtg tacttcgcct ctatcgagaa gagcaacatc      300

atcagaggct ggatctttgg caccacactg gactccaaga cacagtctct gctgatcgtg      360

aacaatgcca ccaacgtggt catcaaggtg tgcgagttcc agttttgtaa tgatcccttc      420

ctggacgtgt actatcacaa gaacaataag agctggatgg agtccggagt gtattctagc      480

gccaacaact gcacatttga gtacgtgagc cagcctttcc tgatggacct ggagggcaag      540

cagggcaatt tcaagaacct gagggagttc gtgtttaaga atatcgacgg ctacttcaaa      600

atctactcta agcacacccc catcaacctg gtgcgcgacc tgcctcaggg cttcagcgcc      660

ctggagcccc tggtggatct gcctatcggc atcaacatca cccggtttca gacactgctg      720

gccctgcaca gaagctacct gacacccggc gactcctcta gcggatggac cgccggcgct      780

gccgcctact atgtgggcta cctccagccc cggaccttcc tgctgaagta caacgagaat      840

ggcaccatca cagacgcagt ggattgcgcc ctggaccccc tgagcgagac aaagtgtaca      900

ctgaagtcct ttaccgtgga gaagggcatc tatcagacat ccaatttcag ggtgcagcca      960

accgagtcta tcgtgcgctt tcctaatatc acaaacctgt gcccatttgg cgaggtgttc     1020

aacgcaaccc gcttcgccag cgtgtacgcc tggaatagga agcggatcag caactgcgtg     1080

gccgactata gcgtgctgta caactccgcc tctttcagca cctttaagtg ctatggcgtg     1140

tcccccacaa agctgaatga cctgtgcttt accaacgtct acgccgattc tttcgtgatc     1200

aggggcgacg aggtgcgcca gatcgccccc ggccagacag gcaagatcgc agactacaat     1260

tataagctgc cagacgattt caccggctgc gtgatcgcct ggaacagcaa caatctggat     1320

tccaaagtgg gcggcaacta caattatcgg taccggctgt ttagaaagag caatctgaag     1380

cccttcgaga gggacatctc tacagaaatc taccaggccg gcagcaagcc ttgcaatggc     1440

gtggagggct ttaactgtta tttcccactc cagtcctacg gcttccagcc cacaaacggc     1500

gtgggctatc agccttaccg cgtggtggtg ctgagctttg agctgctgca cgccccagca     1560

acagtgtgcg gccccaagaa gtccaccaat ctggtgaaga acaagtgcgt gaacttcaac     1620

ttcaacggcc tgaccggcac aggcgtgctg accgagtcca acaagaagtt cctgccattt     1680

cagcagttcg gcagggacat cgcagatacc acagacgccg tgcgcgaccc acagaccctg     1740

gagatcctgg acatcacacc ctgctctttc ggcggcgtga gcgtgatcac acccggcacc     1800

aatacaagca accaggtggc cgtgctgtat cagggcgtga attgtaccga ggtgcccgtg     1860

gctatccacg ccgatcagct gaccccaaca tggcgggtgt acagcaccgg ctccaacgtc     1920

ttccagacaa gagccggatg cctgatcgga gcagagcacg tgaacaattc ctatgagtgc     1980

gacatcccaa tcggcgccgg catctgtgcc tcttaccaga cccagacaaa ctctcgcaga     2040

agagcccgga gcgtggcctc ccagtctatc atcgcctata ccatgtccct gggcgccgag     2100

aacagcgtgg cctactctaa caatagcatc gccatcccaa ccaacttcac aatctctgtg     2160

accacagaga tcctgcccgt gtccatgacc aagacatctg tggactgcac aatgtatatc     2220

tgtggcgatt ctaccgagtg cagcaacctg ctgctccagt acggcagctt ttgtacccag     2280

ctgaatagag ccctgacagg catcgccgtg gagcaggata agaacacaca ggaggtgttc     2340

gcccaggtga agcaaatcta caagaccccc cctatcaagg actttggcgg cttcaatttt     2400

tcccagatcc tgcctgatcc atccaagcct tctaagcgga gctttatcga ggacctgctg     2460

ttcaacaagg tgaccctggc cgatgccggc ttcatcaagc agtatggcga ttgcctgggc     2520

gacatcgcag ccagggacct gatctgcgcc cagaagttta atggcctgac cgtgctgcca     2580

cccctgctga cagatgagat gatcgcacag tacacaagcg ccctgctggc cggcaccatc     2640

acatccggat ggaccttcgg cgcaggagcc gccctccaga tcccctttgc catgcagatg     2700

gcctataggt tcaacggcat cggcgtgacc cagaatgtgc tgtacgagaa ccagaagctg     2760

atcgccaatc agtttaactc cgccatcggc aagatccagg acagcctgtc ctctacagcc     2820

agcgccctgg gcaagctcca gaatgtggtg aatcagaacg cccaggccct gaataccctg     2880

gtgaagcagc tgagcagcaa cttcggcgcc atctctagcg tgctgaatga catcctgagc     2940

cggctggacc cgccggaggc agaggtgcag atcgaccggc tgatcaccgg ccggctccag     3000

agcctccaga cctatgtgac acagcagctg atcagggccg ccgagatcag ggccagcgcc     3060

aatctggcag caaccaagat gtccgagtgc gtgctgggcc agtctaagag agtggacttt     3120

tgtggcaagg gctatcacct gatgtccttc cctcagtctg ccccacacgg cgtggtgttt     3180

ctgcacgtga cctacgtgcc cgcccaggag aagaacttca ccacagcccc tgccatctgc     3240

cacgatggca aggcccactt tccaagggag ggcgtgttcg tgtccaacgg cacccactgg     3300

tttgtgacac agcgcaattt ctacgagccc cagatcatca ccacagacaa caccttcgtg     3360

agcggcaact gtgacgtggt catcggcatc gtgaacaata ccgtgtatga tccactccag     3420

cccgagctgg acagctttaa ggaggagctg gataagtatt tcaagaatca cacctcccct     3480

gacgtggatc tgggcgacat cagcggcatc aatgcctccg tggtgaacat ccagaaggag     3540

atcgaccgcc tgaacgaggt ggctaagaat ctgaacgaga gcctgatcga cctccaggag     3600

ctgggcaagt atgagcagta catcaagtgg ccctggtaca tctggctggg cttcatcgcc     3660

ggcctgatcg ccatcgtgat ggtgaccatc atgctgtgct gtatgacatc ctgctgttct     3720

tgcctgaagg gctgctgtag ctgtggctcc tgctgtaagt ttgacgagga tgactctgaa     3780

cctgtgctga agggcgtgaa gctgcattac acctaa                               3816


<210>  20
<211>  1271
<212>  PRT
<213>  SARS-CoV-2 (Delta S-2P strain)

<400>  20

Met Phe Val Phe Leu Val Leu Leu Pro Leu Val Ser Ser Gln Cys Val 
1               5                   10                  15      


Asn Leu Arg Thr Arg Thr Gln Leu Pro Pro Ala Tyr Thr Asn Ser Phe 
            20                  25                  30          


Thr Arg Gly Val Tyr Tyr Pro Asp Lys Val Phe Arg Ser Ser Val Leu 
        35                  40                  45              


His Ser Thr Gln Asp Leu Phe Leu Pro Phe Phe Ser Asn Val Thr Trp 
    50                  55                  60                  


Phe His Ala Ile His Val Ser Gly Thr Asn Gly Thr Lys Arg Phe Asp 
65                  70                  75                  80  


Asn Pro Val Leu Pro Phe Asn Asp Gly Val Tyr Phe Ala Ser Ile Glu 
                85                  90                  95      


Lys Ser Asn Ile Ile Arg Gly Trp Ile Phe Gly Thr Thr Leu Asp Ser 
            100                 105                 110         


Lys Thr Gln Ser Leu Leu Ile Val Asn Asn Ala Thr Asn Val Val Ile 
        115                 120                 125             


Lys Val Cys Glu Phe Gln Phe Cys Asn Asp Pro Phe Leu Asp Val Tyr 
    130                 135                 140                 


Tyr His Lys Asn Asn Lys Ser Trp Met Glu Ser Gly Val Tyr Ser Ser 
145                 150                 155                 160 


Ala Asn Asn Cys Thr Phe Glu Tyr Val Ser Gln Pro Phe Leu Met Asp 
                165                 170                 175     


Leu Glu Gly Lys Gln Gly Asn Phe Lys Asn Leu Arg Glu Phe Val Phe 
            180                 185                 190         


Lys Asn Ile Asp Gly Tyr Phe Lys Ile Tyr Ser Lys His Thr Pro Ile 
        195                 200                 205             


Asn Leu Val Arg Asp Leu Pro Gln Gly Phe Ser Ala Leu Glu Pro Leu 
    210                 215                 220                 


Val Asp Leu Pro Ile Gly Ile Asn Ile Thr Arg Phe Gln Thr Leu Leu 
225                 230                 235                 240 


Ala Leu His Arg Ser Tyr Leu Thr Pro Gly Asp Ser Ser Ser Gly Trp 
                245                 250                 255     


Thr Ala Gly Ala Ala Ala Tyr Tyr Val Gly Tyr Leu Gln Pro Arg Thr 
            260                 265                 270         


Phe Leu Leu Lys Tyr Asn Glu Asn Gly Thr Ile Thr Asp Ala Val Asp 
        275                 280                 285             


Cys Ala Leu Asp Pro Leu Ser Glu Thr Lys Cys Thr Leu Lys Ser Phe 
    290                 295                 300                 


Thr Val Glu Lys Gly Ile Tyr Gln Thr Ser Asn Phe Arg Val Gln Pro 
305                 310                 315                 320 


Thr Glu Ser Ile Val Arg Phe Pro Asn Ile Thr Asn Leu Cys Pro Phe 
                325                 330                 335     


Gly Glu Val Phe Asn Ala Thr Arg Phe Ala Ser Val Tyr Ala Trp Asn 
            340                 345                 350         


Arg Lys Arg Ile Ser Asn Cys Val Ala Asp Tyr Ser Val Leu Tyr Asn 
        355                 360                 365             


Ser Ala Ser Phe Ser Thr Phe Lys Cys Tyr Gly Val Ser Pro Thr Lys 
    370                 375                 380                 


Leu Asn Asp Leu Cys Phe Thr Asn Val Tyr Ala Asp Ser Phe Val Ile 
385                 390                 395                 400 


Arg Gly Asp Glu Val Arg Gln Ile Ala Pro Gly Gln Thr Gly Lys Ile 
                405                 410                 415     


Ala Asp Tyr Asn Tyr Lys Leu Pro Asp Asp Phe Thr Gly Cys Val Ile 
            420                 425                 430         


Ala Trp Asn Ser Asn Asn Leu Asp Ser Lys Val Gly Gly Asn Tyr Asn 
        435                 440                 445             


Tyr Arg Tyr Arg Leu Phe Arg Lys Ser Asn Leu Lys Pro Phe Glu Arg 
    450                 455                 460                 


Asp Ile Ser Thr Glu Ile Tyr Gln Ala Gly Ser Lys Pro Cys Asn Gly 
465                 470                 475                 480 


Val Glu Gly Phe Asn Cys Tyr Phe Pro Leu Gln Ser Tyr Gly Phe Gln 
                485                 490                 495     


Pro Thr Asn Gly Val Gly Tyr Gln Pro Tyr Arg Val Val Val Leu Ser 
            500                 505                 510         


Phe Glu Leu Leu His Ala Pro Ala Thr Val Cys Gly Pro Lys Lys Ser 
        515                 520                 525             


Thr Asn Leu Val Lys Asn Lys Cys Val Asn Phe Asn Phe Asn Gly Leu 
    530                 535                 540                 


Thr Gly Thr Gly Val Leu Thr Glu Ser Asn Lys Lys Phe Leu Pro Phe 
545                 550                 555                 560 


Gln Gln Phe Gly Arg Asp Ile Ala Asp Thr Thr Asp Ala Val Arg Asp 
                565                 570                 575     


Pro Gln Thr Leu Glu Ile Leu Asp Ile Thr Pro Cys Ser Phe Gly Gly 
            580                 585                 590         


Val Ser Val Ile Thr Pro Gly Thr Asn Thr Ser Asn Gln Val Ala Val 
        595                 600                 605             


Leu Tyr Gln Gly Val Asn Cys Thr Glu Val Pro Val Ala Ile His Ala 
    610                 615                 620                 


Asp Gln Leu Thr Pro Thr Trp Arg Val Tyr Ser Thr Gly Ser Asn Val 
625                 630                 635                 640 


Phe Gln Thr Arg Ala Gly Cys Leu Ile Gly Ala Glu His Val Asn Asn 
                645                 650                 655     


Ser Tyr Glu Cys Asp Ile Pro Ile Gly Ala Gly Ile Cys Ala Ser Tyr 
            660                 665                 670         


Gln Thr Gln Thr Asn Ser Arg Arg Arg Ala Arg Ser Val Ala Ser Gln 
        675                 680                 685             


Ser Ile Ile Ala Tyr Thr Met Ser Leu Gly Ala Glu Asn Ser Val Ala 
    690                 695                 700                 


Tyr Ser Asn Asn Ser Ile Ala Ile Pro Thr Asn Phe Thr Ile Ser Val 
705                 710                 715                 720 


Thr Thr Glu Ile Leu Pro Val Ser Met Thr Lys Thr Ser Val Asp Cys 
                725                 730                 735     


Thr Met Tyr Ile Cys Gly Asp Ser Thr Glu Cys Ser Asn Leu Leu Leu 
            740                 745                 750         


Gln Tyr Gly Ser Phe Cys Thr Gln Leu Asn Arg Ala Leu Thr Gly Ile 
        755                 760                 765             


Ala Val Glu Gln Asp Lys Asn Thr Gln Glu Val Phe Ala Gln Val Lys 
    770                 775                 780                 


Gln Ile Tyr Lys Thr Pro Pro Ile Lys Asp Phe Gly Gly Phe Asn Phe 
785                 790                 795                 800 


Ser Gln Ile Leu Pro Asp Pro Ser Lys Pro Ser Lys Arg Ser Phe Ile 
                805                 810                 815     


Glu Asp Leu Leu Phe Asn Lys Val Thr Leu Ala Asp Ala Gly Phe Ile 
            820                 825                 830         


Lys Gln Tyr Gly Asp Cys Leu Gly Asp Ile Ala Ala Arg Asp Leu Ile 
        835                 840                 845             


Cys Ala Gln Lys Phe Asn Gly Leu Thr Val Leu Pro Pro Leu Leu Thr 
    850                 855                 860                 


Asp Glu Met Ile Ala Gln Tyr Thr Ser Ala Leu Leu Ala Gly Thr Ile 
865                 870                 875                 880 


Thr Ser Gly Trp Thr Phe Gly Ala Gly Ala Ala Leu Gln Ile Pro Phe 
                885                 890                 895     


Ala Met Gln Met Ala Tyr Arg Phe Asn Gly Ile Gly Val Thr Gln Asn 
            900                 905                 910         


Val Leu Tyr Glu Asn Gln Lys Leu Ile Ala Asn Gln Phe Asn Ser Ala 
        915                 920                 925             


Ile Gly Lys Ile Gln Asp Ser Leu Ser Ser Thr Ala Ser Ala Leu Gly 
    930                 935                 940                 


Lys Leu Gln Asn Val Val Asn Gln Asn Ala Gln Ala Leu Asn Thr Leu 
945                 950                 955                 960 


Val Lys Gln Leu Ser Ser Asn Phe Gly Ala Ile Ser Ser Val Leu Asn 
                965                 970                 975     


Asp Ile Leu Ser Arg Leu Asp Pro Pro Glu Ala Glu Val Gln Ile Asp 
            980                 985                 990         


Arg Leu Ile Thr Gly Arg Leu Gln  Ser Leu Gln Thr Tyr  Val Thr Gln 
        995                 1000                 1005             


Gln Leu  Ile Arg Ala Ala Glu  Ile Arg Ala Ser Ala  Asn Leu Ala 
    1010                 1015                 1020             


Ala Thr  Lys Met Ser Glu Cys  Val Leu Gly Gln Ser  Lys Arg Val 
    1025                 1030                 1035             


Asp Phe  Cys Gly Lys Gly Tyr  His Leu Met Ser Phe  Pro Gln Ser 
    1040                 1045                 1050             


Ala Pro  His Gly Val Val Phe  Leu His Val Thr Tyr  Val Pro Ala 
    1055                 1060                 1065             


Gln Glu  Lys Asn Phe Thr Thr  Ala Pro Ala Ile Cys  His Asp Gly 
    1070                 1075                 1080             


Lys Ala  His Phe Pro Arg Glu  Gly Val Phe Val Ser  Asn Gly Thr 
    1085                 1090                 1095             


His Trp  Phe Val Thr Gln Arg  Asn Phe Tyr Glu Pro  Gln Ile Ile 
    1100                 1105                 1110             


Thr Thr  Asp Asn Thr Phe Val  Ser Gly Asn Cys Asp  Val Val Ile 
    1115                 1120                 1125             


Gly Ile  Val Asn Asn Thr Val  Tyr Asp Pro Leu Gln  Pro Glu Leu 
    1130                 1135                 1140             


Asp Ser  Phe Lys Glu Glu Leu  Asp Lys Tyr Phe Lys  Asn His Thr 
    1145                 1150                 1155             


Ser Pro  Asp Val Asp Leu Gly  Asp Ile Ser Gly Ile  Asn Ala Ser 
    1160                 1165                 1170             


Val Val  Asn Ile Gln Lys Glu  Ile Asp Arg Leu Asn  Glu Val Ala 
    1175                 1180                 1185             


Lys Asn  Leu Asn Glu Ser Leu  Ile Asp Leu Gln Glu  Leu Gly Lys 
    1190                 1195                 1200             


Tyr Glu  Gln Tyr Ile Lys Trp  Pro Trp Tyr Ile Trp  Leu Gly Phe 
    1205                 1210                 1215             


Ile Ala  Gly Leu Ile Ala Ile  Val Met Val Thr Ile  Met Leu Cys 
    1220                 1225                 1230             


Cys Met  Thr Ser Cys Cys Ser  Cys Leu Lys Gly Cys  Cys Ser Cys 
    1235                 1240                 1245             


Gly Ser  Cys Cys Lys Phe Asp  Glu Asp Asp Ser Glu  Pro Val Leu 
    1250                 1255                 1260             


Lys Gly  Val Lys Leu His Tyr  Thr 
    1265                 1270     


<210>  21
<211>  3816
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  S-(deg-RBD) for Delta strain

<400>  21
atgttcgtct tcctggtcct gctgcctctg gtctcctcac agtgcgtcaa tctgcgaact       60

cggactcagc tgccacctgc ttatactaat agcttcacca gaggcgtgta ctatcctgac      120

aaggtgttta gaagctccgt gctgcactct acacaggatc tgtttctgcc attctttagc      180

aacgtgacct ggttccacgc catccacgtg agcggcacca atggcacaaa gcggttcgac      240

aatcccgtgc tgccttttaa cgatggcgtg tacttcgcct ctatcgagaa gagcaacatc      300

atcagaggct ggatctttgg caccacactg gactccaaga cacagtctct gctgatcgtg      360

aacaatgcca ccaacgtggt catcaaggtg tgcgagttcc agttttgtaa tgatcccttc      420

ctggacgtgt actatcacaa gaacaataag agctggatgg agtccggagt gtattctagc      480

gccaacaact gcacatttga gtacgtgagc cagcctttcc tgatggacct ggagggcaag      540

cagggcaatt tcaagaacct gagggagttc gtgtttaaga atatcgacgg ctacttcaaa      600

atctactcta agcacacccc catcaacctg gtgcgcgacc tgcctcaggg cttcagcgcc      660

ctggagcccc tggtggatct gcctatcggc atcaacatca cccggtttca gacactgctg      720

gccctgcaca gaagctacct gacacccggc gactcctcta gcggatggac cgccggcgct      780

gccgcctact atgtgggcta cctccagccc cggaccttcc tgctgaagta caacgagaat      840

ggcaccatca cagacgcagt ggattgcgcc ctggaccccc tgagcgagac aaagtgtaca      900

ctgaagtcct ttaccgtgga gaagggcatc tatcagacat ccaatttcag ggtgcagcca      960

gccgaggcga tcgtgcgctt tcctgaaatc acaaacctgt gcccatttgg cgaggtgttc     1020

gaggcaaccc gcttcgccag cgtgtacgcc tggaatagga agcggatcag caactgcgtg     1080

gccgactata gcgtgctgta caactccgcc tctttcagca cctttaagtg ctatggcgtg     1140

tcccccacaa agctgaatga cctgtgcttt accaacgtct acgccgattc tttcgtgatc     1200

aggggcgacg aggtgcgcca gatcgccccc ggccagacag gcaagatcgc agactacaat     1260

tataagctgc cagacgattt caccggctgc gtgatcgcct ggaacagcaa caatctggat     1320

tccaaagtgg gcggcaacta caattatcgg taccggctgt ttagaaagag caatctgaag     1380

cccttcgaga gggacatctc tacagaaatc taccaggccg gcagcaagcc ttgcaatggc     1440

gtggagggct ttaactgtta tttcccactc cagtcctacg gcttccagcc cacaaacggc     1500

gtgggctatc agccttaccg cgtggtggtg ctgagctttg agctgctgca cgccccagca     1560

acagtgtgcg gccccaagaa gtccaccaat ctggtgaaga acaagtgcgt gaacttcaac     1620

ttcaacggcc tgaccggcac aggcgtgctg accgagtcca acaagaagtt cctgccattt     1680

cagcagttcg gcagggacat cgcagatacc acagacgccg tgcgcgaccc acagaccctg     1740

gagatcctgg acatcacacc ctgctctttc ggcggcgtga gcgtgatcac acccggcacc     1800

aatacaagca accaggtggc cgtgctgtat cagggcgtga attgtaccga ggtgcccgtg     1860

gctatccacg ccgatcagct gaccccaaca tggcgggtgt acagcaccgg ctccaacgtc     1920

ttccagacaa gagccggatg cctgatcgga gcagagcacg tgaacaattc ctatgagtgc     1980

gacatcccaa tcggcgccgg catctgtgcc tcttaccaga cccagacaaa ctctcgcaga     2040

agagcccgga gcgtggcctc ccagtctatc atcgcctata ccatgtccct gggcgccgag     2100

aacagcgtgg cctactctaa caatagcatc gccatcccaa ccaacttcac aatctctgtg     2160

accacagaga tcctgcccgt gtccatgacc aagacatctg tggactgcac aatgtatatc     2220

tgtggcgatt ctaccgagtg cagcaacctg ctgctccagt acggcagctt ttgtacccag     2280

ctgaatagag ccctgacagg catcgccgtg gagcaggata agaacacaca ggaggtgttc     2340

gcccaggtga agcaaatcta caagaccccc cctatcaagg actttggcgg cttcaatttt     2400

tcccagatcc tgcctgatcc atccaagcct tctaagcgga gctttatcga ggacctgctg     2460

ttcaacaagg tgaccctggc cgatgccggc ttcatcaagc agtatggcga ttgcctgggc     2520

gacatcgcag ccagggacct gatctgcgcc cagaagttta atggcctgac cgtgctgcca     2580

cccctgctga cagatgagat gatcgcacag tacacaagcg ccctgctggc cggcaccatc     2640

acatccggat ggaccttcgg cgcaggagcc gccctccaga tcccctttgc catgcagatg     2700

gcctataggt tcaacggcat cggcgtgacc cagaatgtgc tgtacgagaa ccagaagctg     2760

atcgccaatc agtttaactc cgccatcggc aagatccagg acagcctgtc ctctacagcc     2820

agcgccctgg gcaagctcca gaatgtggtg aatcagaacg cccaggccct gaataccctg     2880

gtgaagcagc tgagcagcaa cttcggcgcc atctctagcg tgctgaatga catcctgagc     2940

cggctggaca aggtggaggc agaggtgcag atcgaccggc tgatcaccgg ccggctccag     3000

agcctccaga cctatgtgac acagcagctg atcagggccg ccgagatcag ggccagcgcc     3060

aatctggcag caaccaagat gtccgagtgc gtgctgggcc agtctaagag agtggacttt     3120

tgtggcaagg gctatcacct gatgtccttc cctcagtctg ccccacacgg cgtggtgttt     3180

ctgcacgtga cctacgtgcc cgcccaggag aagaacttca ccacagcccc tgccatctgc     3240

cacgatggca aggcccactt tccaagggag ggcgtgttcg tgtccaacgg cacccactgg     3300

tttgtgacac agcgcaattt ctacgagccc cagatcatca ccacagacaa caccttcgtg     3360

agcggcaact gtgacgtggt catcggcatc gtgaacaata ccgtgtatga tccactccag     3420

cccgagctgg acagctttaa ggaggagctg gataagtatt tcaagaatca cacctcccct     3480

gacgtggatc tgggcgacat cagcggcatc aatgcctccg tggtgaacat ccagaaggag     3540

atcgaccgcc tgaacgaggt ggctaagaat ctgaacgaga gcctgatcga cctccaggag     3600

ctgggcaagt atgagcagta catcaagtgg ccctggtaca tctggctggg cttcatcgcc     3660

ggcctgatcg ccatcgtgat ggtgaccatc atgctgtgct gtatgacatc ctgctgttct     3720

tgcctgaagg gctgctgtag ctgtggctcc tgctgtaagt ttgacgagga tgactctgaa     3780

cctgtgctga agggcgtgaa gctgcattac acctaa                               3816


<210>  22
<211>  1271
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  S-(deg-RBD) for Delta strain

<400>  22

Met Phe Val Phe Leu Val Leu Leu Pro Leu Val Ser Ser Gln Cys Val 
1               5                   10                  15      


Asn Leu Arg Thr Arg Thr Gln Leu Pro Pro Ala Tyr Thr Asn Ser Phe 
            20                  25                  30          


Thr Arg Gly Val Tyr Tyr Pro Asp Lys Val Phe Arg Ser Ser Val Leu 
        35                  40                  45              


His Ser Thr Gln Asp Leu Phe Leu Pro Phe Phe Ser Asn Val Thr Trp 
    50                  55                  60                  


Phe His Ala Ile His Val Ser Gly Thr Asn Gly Thr Lys Arg Phe Asp 
65                  70                  75                  80  


Asn Pro Val Leu Pro Phe Asn Asp Gly Val Tyr Phe Ala Ser Ile Glu 
                85                  90                  95      


Lys Ser Asn Ile Ile Arg Gly Trp Ile Phe Gly Thr Thr Leu Asp Ser 
            100                 105                 110         


Lys Thr Gln Ser Leu Leu Ile Val Asn Asn Ala Thr Asn Val Val Ile 
        115                 120                 125             


Lys Val Cys Glu Phe Gln Phe Cys Asn Asp Pro Phe Leu Asp Val Tyr 
    130                 135                 140                 


Tyr His Lys Asn Asn Lys Ser Trp Met Glu Ser Gly Val Tyr Ser Ser 
145                 150                 155                 160 


Ala Asn Asn Cys Thr Phe Glu Tyr Val Ser Gln Pro Phe Leu Met Asp 
                165                 170                 175     


Leu Glu Gly Lys Gln Gly Asn Phe Lys Asn Leu Arg Glu Phe Val Phe 
            180                 185                 190         


Lys Asn Ile Asp Gly Tyr Phe Lys Ile Tyr Ser Lys His Thr Pro Ile 
        195                 200                 205             


Asn Leu Val Arg Asp Leu Pro Gln Gly Phe Ser Ala Leu Glu Pro Leu 
    210                 215                 220                 


Val Asp Leu Pro Ile Gly Ile Asn Ile Thr Arg Phe Gln Thr Leu Leu 
225                 230                 235                 240 


Ala Leu His Arg Ser Tyr Leu Thr Pro Gly Asp Ser Ser Ser Gly Trp 
                245                 250                 255     


Thr Ala Gly Ala Ala Ala Tyr Tyr Val Gly Tyr Leu Gln Pro Arg Thr 
            260                 265                 270         


Phe Leu Leu Lys Tyr Asn Glu Asn Gly Thr Ile Thr Asp Ala Val Asp 
        275                 280                 285             


Cys Ala Leu Asp Pro Leu Ser Glu Thr Lys Cys Thr Leu Lys Ser Phe 
    290                 295                 300                 


Thr Val Glu Lys Gly Ile Tyr Gln Thr Ser Asn Phe Arg Val Gln Pro 
305                 310                 315                 320 


Ala Glu Ala Ile Val Arg Phe Pro Gln Ile Thr Asn Leu Cys Pro Phe 
                325                 330                 335     


Gly Glu Val Phe Gln Ala Thr Arg Phe Ala Ser Val Tyr Ala Trp Asn 
            340                 345                 350         


Arg Lys Arg Ile Ser Asn Cys Val Ala Asp Tyr Ser Val Leu Tyr Asn 
        355                 360                 365             


Ser Ala Ser Phe Ser Thr Phe Lys Cys Tyr Gly Val Ser Pro Thr Lys 
    370                 375                 380                 


Leu Asn Asp Leu Cys Phe Thr Asn Val Tyr Ala Asp Ser Phe Val Ile 
385                 390                 395                 400 


Arg Gly Asp Glu Val Arg Gln Ile Ala Pro Gly Gln Thr Gly Lys Ile 
                405                 410                 415     


Ala Asp Tyr Asn Tyr Lys Leu Pro Asp Asp Phe Thr Gly Cys Val Ile 
            420                 425                 430         


Ala Trp Asn Ser Asn Asn Leu Asp Ser Lys Val Gly Gly Asn Tyr Asn 
        435                 440                 445             


Tyr Arg Tyr Arg Leu Phe Arg Lys Ser Asn Leu Lys Pro Phe Glu Arg 
    450                 455                 460                 


Asp Ile Ser Thr Glu Ile Tyr Gln Ala Gly Ser Lys Pro Cys Asn Gly 
465                 470                 475                 480 


Val Glu Gly Phe Asn Cys Tyr Phe Pro Leu Gln Ser Tyr Gly Phe Gln 
                485                 490                 495     


Pro Thr Asn Gly Val Gly Tyr Gln Pro Tyr Arg Val Val Val Leu Ser 
            500                 505                 510         


Phe Glu Leu Leu His Ala Pro Ala Thr Val Cys Gly Pro Lys Lys Ser 
        515                 520                 525             


Thr Asn Leu Val Lys Asn Lys Cys Val Asn Phe Asn Phe Asn Gly Leu 
    530                 535                 540                 


Thr Gly Thr Gly Val Leu Thr Glu Ser Asn Lys Lys Phe Leu Pro Phe 
545                 550                 555                 560 


Gln Gln Phe Gly Arg Asp Ile Ala Asp Thr Thr Asp Ala Val Arg Asp 
                565                 570                 575     


Pro Gln Thr Leu Glu Ile Leu Asp Ile Thr Pro Cys Ser Phe Gly Gly 
            580                 585                 590         


Val Ser Val Ile Thr Pro Gly Thr Asn Thr Ser Asn Gln Val Ala Val 
        595                 600                 605             


Leu Tyr Gln Gly Val Asn Cys Thr Glu Val Pro Val Ala Ile His Ala 
    610                 615                 620                 


Asp Gln Leu Thr Pro Thr Trp Arg Val Tyr Ser Thr Gly Ser Asn Val 
625                 630                 635                 640 


Phe Gln Thr Arg Ala Gly Cys Leu Ile Gly Ala Glu His Val Asn Asn 
                645                 650                 655     


Ser Tyr Glu Cys Asp Ile Pro Ile Gly Ala Gly Ile Cys Ala Ser Tyr 
            660                 665                 670         


Gln Thr Gln Thr Asn Ser Arg Arg Arg Ala Arg Ser Val Ala Ser Gln 
        675                 680                 685             


Ser Ile Ile Ala Tyr Thr Met Ser Leu Gly Ala Glu Asn Ser Val Ala 
    690                 695                 700                 


Tyr Ser Asn Asn Ser Ile Ala Ile Pro Thr Asn Phe Thr Ile Ser Val 
705                 710                 715                 720 


Thr Thr Glu Ile Leu Pro Val Ser Met Thr Lys Thr Ser Val Asp Cys 
                725                 730                 735     


Thr Met Tyr Ile Cys Gly Asp Ser Thr Glu Cys Ser Asn Leu Leu Leu 
            740                 745                 750         


Gln Tyr Gly Ser Phe Cys Thr Gln Leu Asn Arg Ala Leu Thr Gly Ile 
        755                 760                 765             


Ala Val Glu Gln Asp Lys Asn Thr Gln Glu Val Phe Ala Gln Val Lys 
    770                 775                 780                 


Gln Ile Tyr Lys Thr Pro Pro Ile Lys Asp Phe Gly Gly Phe Asn Phe 
785                 790                 795                 800 


Ser Gln Ile Leu Pro Asp Pro Ser Lys Pro Ser Lys Arg Ser Phe Ile 
                805                 810                 815     


Glu Asp Leu Leu Phe Asn Lys Val Thr Leu Ala Asp Ala Gly Phe Ile 
            820                 825                 830         


Lys Gln Tyr Gly Asp Cys Leu Gly Asp Ile Ala Ala Arg Asp Leu Ile 
        835                 840                 845             


Cys Ala Gln Lys Phe Asn Gly Leu Thr Val Leu Pro Pro Leu Leu Thr 
    850                 855                 860                 


Asp Glu Met Ile Ala Gln Tyr Thr Ser Ala Leu Leu Ala Gly Thr Ile 
865                 870                 875                 880 


Thr Ser Gly Trp Thr Phe Gly Ala Gly Ala Ala Leu Gln Ile Pro Phe 
                885                 890                 895     


Ala Met Gln Met Ala Tyr Arg Phe Asn Gly Ile Gly Val Thr Gln Asn 
            900                 905                 910         


Val Leu Tyr Glu Asn Gln Lys Leu Ile Ala Asn Gln Phe Asn Ser Ala 
        915                 920                 925             


Ile Gly Lys Ile Gln Asp Ser Leu Ser Ser Thr Ala Ser Ala Leu Gly 
    930                 935                 940                 


Lys Leu Gln Asn Val Val Asn Gln Asn Ala Gln Ala Leu Asn Thr Leu 
945                 950                 955                 960 


Val Lys Gln Leu Ser Ser Asn Phe Gly Ala Ile Ser Ser Val Leu Asn 
                965                 970                 975     


Asp Ile Leu Ser Arg Leu Asp Lys Val Glu Ala Glu Val Gln Ile Asp 
            980                 985                 990         


Arg Leu Ile Thr Gly Arg Leu Gln  Ser Leu Gln Thr Tyr  Val Thr Gln 
        995                 1000                 1005             


Gln Leu  Ile Arg Ala Ala Glu  Ile Arg Ala Ser Ala  Asn Leu Ala 
    1010                 1015                 1020             


Ala Thr  Lys Met Ser Glu Cys  Val Leu Gly Gln Ser  Lys Arg Val 
    1025                 1030                 1035             


Asp Phe  Cys Gly Lys Gly Tyr  His Leu Met Ser Phe  Pro Gln Ser 
    1040                 1045                 1050             


Ala Pro  His Gly Val Val Phe  Leu His Val Thr Tyr  Val Pro Ala 
    1055                 1060                 1065             


Gln Glu  Lys Asn Phe Thr Thr  Ala Pro Ala Ile Cys  His Asp Gly 
    1070                 1075                 1080             


Lys Ala  His Phe Pro Arg Glu  Gly Val Phe Val Ser  Asn Gly Thr 
    1085                 1090                 1095             


His Trp  Phe Val Thr Gln Arg  Asn Phe Tyr Glu Pro  Gln Ile Ile 
    1100                 1105                 1110             


Thr Thr  Asp Asn Thr Phe Val  Ser Gly Asn Cys Asp  Val Val Ile 
    1115                 1120                 1125             


Gly Ile  Val Asn Asn Thr Val  Tyr Asp Pro Leu Gln  Pro Glu Leu 
    1130                 1135                 1140             


Asp Ser  Phe Lys Glu Glu Leu  Asp Lys Tyr Phe Lys  Asn His Thr 
    1145                 1150                 1155             


Ser Pro  Asp Val Asp Leu Gly  Asp Ile Ser Gly Ile  Asn Ala Ser 
    1160                 1165                 1170             


Val Val  Asn Ile Gln Lys Glu  Ile Asp Arg Leu Asn  Glu Val Ala 
    1175                 1180                 1185             


Lys Asn  Leu Asn Glu Ser Leu  Ile Asp Leu Gln Glu  Leu Gly Lys 
    1190                 1195                 1200             


Tyr Glu  Gln Tyr Ile Lys Trp  Pro Trp Tyr Ile Trp  Leu Gly Phe 
    1205                 1210                 1215             


Ile Ala  Gly Leu Ile Ala Ile  Val Met Val Thr Ile  Met Leu Cys 
    1220                 1225                 1230             


Cys Met  Thr Ser Cys Cys Ser  Cys Leu Lys Gly Cys  Cys Ser Cys 
    1235                 1240                 1245             


Gly Ser  Cys Cys Lys Phe Asp  Glu Asp Asp Ser Glu  Pro Val Leu 
    1250                 1255                 1260             


Lys Gly  Val Lys Leu His Tyr  Thr 
    1265                 1270     


<210>  23
<211>  3822
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  S-(deg-RBD) for Wuhan S-2P strain

<400>  23
atgttcgtct tcctggtcct gctgcctctg gtctcctcac agtgcgtcaa tctgacaact       60

cggactcagc tgccacctgc ttatactaat agcttcacca gaggcgtgta ctatcctgac      120

aaggtgttta gaagctccgt gctgcactct acacaggatc tgtttctgcc attctttagc      180

aacgtgacct ggttccacgc catccacgtg agcggcacca atggcacaaa gcggttcgac      240

aatcccgtgc tgccttttaa cgatggcgtg tacttcgcct ctaccgagaa gagcaacatc      300

atcagaggct ggatctttgg caccacactg gactccaaga cacagtctct gctgatcgtg      360

aacaatgcca ccaacgtggt catcaaggtg tgcgagttcc agttttgtaa tgatcccttc      420

ctgggcgtgt actatcacaa gaacaataag agctggatgg agtccgagtt tagagtgtat      480

tctagcgcca acaactgcac atttgagtac gtgagccagc ctttcctgat ggacctggag      540

ggcaagcagg gcaatttcaa gaacctgagg gagttcgtgt ttaagaatat cgacggctac      600

ttcaaaatct actctaagca cacccccatc aacctggtgc gcgacctgcc tcagggcttc      660

agcgccctgg agcccctggt ggatctgcct atcggcatca acatcacccg gtttcagaca      720

ctgctggccc tgcacagaag ctacctgaca cccggcgact cctctagcgg atggaccgcc      780

ggcgctgccg cctactatgt gggctacctc cagccccgga ccttcctgct gaagtacaac      840

gagaatggca ccatcacaga cgcagtggat tgcgccctgg accccctgag cgagacaaag      900

tgtacactga agtcctttac cgtggagaag ggcatctatc agacatccaa tttcagggtg      960

cagccagccg aggcgatcgt gcgctttcct gaaatcacaa acctgtgccc atttggcgag     1020

gtgttcgagg caacccgctt cgccagcgtg tacgcctgga ataggaagcg gatcagcaac     1080

tgcgtggccg actatagcgt gctgtacaac tccgcctctt tcagcacctt taagtgctat     1140

ggcgtgtccc ccacaaagct gaatgacctg tgctttacca acgtctacgc cgattctttc     1200

gtgatcaggg gcgacgaggt gcgccagatc gcccccggcc agacaggcaa gatcgcagac     1260

tacaattata agctgccaga cgatttcacc ggctgcgtga tcgcctggaa cagcaacaat     1320

ctggattcca aagtgggcgg caactacaat tatctgtacc ggctgtttag aaagagcaat     1380

ctgaagccct tcgagaggga catctctaca gaaatctacc aggccggcag caccccttgc     1440

aatggcgtgg agggctttaa ctgttatttc ccactccagt cctacggctt ccagcccaca     1500

aacggcgtgg gctatcagcc ttaccgcgtg gtggtgctga gctttgagct gctgcacgcc     1560

ccagcaacag tgtgcggccc caagaagtcc accaatctgg tgaagaacaa gtgcgtgaac     1620

ttcaacttca acggcctgac cggcacaggc gtgctgaccg agtccaacaa gaagttcctg     1680

ccatttcagc agttcggcag ggacatcgca gataccacag acgccgtgcg cgacccacag     1740

accctggaga tcctggacat cacaccctgc tctttcggcg gcgtgagcgt gatcacaccc     1800

ggcaccaata caagcaacca ggtggccgtg ctgtatcagg acgtgaattg taccgaggtg     1860

cccgtggcta tccacgccga tcagctgacc ccaacatggc gggtgtacag caccggctcc     1920

aacgtcttcc agacaagagc cggatgcctg atcggagcag agcacgtgaa caattcctat     1980

gagtgcgaca tcccaatcgg cgccggcatc tgtgcctctt accagaccca gacaaactct     2040

cccagaagag cccggagcgt ggcctcccag tctatcatcg cctataccat gtccctgggc     2100

gccgagaaca gcgtggccta ctctaacaat agcatcgcca tcccaaccaa cttcacaatc     2160

tctgtgacca cagagatcct gcccgtgtcc atgaccaaga catctgtgga ctgcacaatg     2220

tatatctgtg gcgattctac cgagtgcagc aacctgctgc tccagtacgg cagcttttgt     2280

acccagctga atagagccct gacaggcatc gccgtggagc aggataagaa cacacaggag     2340

gtgttcgccc aggtgaagca aatctacaag acccccccta tcaaggactt tggcggcttc     2400

aatttttccc agatcctgcc tgatccatcc aagccttcta agcggagctt tatcgaggac     2460

ctgctgttca acaaggtgac cctggccgat gccggcttca tcaagcagta tggcgattgc     2520

ctgggcgaca tcgcagccag ggacctgatc tgcgcccaga agtttaatgg cctgaccgtg     2580

ctgccacccc tgctgacaga tgagatgatc gcacagtaca caagcgccct gctggccggc     2640

accatcacat ccggatggac cttcggcgca ggagccgccc tccagatccc ctttgccatg     2700

cagatggcct ataggttcaa cggcatcggc gtgacccaga atgtgctgta cgagaaccag     2760

aagctgatcg ccaatcagtt taactccgcc atcggcaaga tccaggacag cctgtcctct     2820

acagccagcg ccctgggcaa gctccaggat gtggtgaatc agaacgccca ggccctgaat     2880

accctggtga agcagctgag cagcaacttc ggcgccatct ctagcgtgct gaatgacatc     2940

ctgagccggc tggacccgcc ggaggcagag gtgcagatcg accggctgat caccggccgg     3000

ctccagagcc tccagaccta tgtgacacag cagctgatca gggccgccga gatcagggcc     3060

agcgccaatc tggcagcaac caagatgtcc gagtgcgtgc tgggccagtc taagagagtg     3120

gacttttgtg gcaagggcta tcacctgatg tccttccctc agtctgcccc acacggcgtg     3180

gtgtttctgc acgtgaccta cgtgcccgcc caggagaaga acttcaccac agcccctgcc     3240

atctgccacg atggcaaggc ccactttcca agggagggcg tgttcgtgtc caacggcacc     3300

cactggtttg tgacacagcg caatttctac gagccccaga tcatcaccac agacaacacc     3360

ttcgtgagcg gcaactgtga cgtggtcatc ggcatcgtga acaataccgt gtatgatcca     3420

ctccagcccg agctggacag ctttaaggag gagctggata agtatttcaa gaatcacacc     3480

tcccctgacg tggatctggg cgacatcagc ggcatcaatg cctccgtggt gaacatccag     3540

aaggagatcg accgcctgaa cgaggtggct aagaatctga acgagagcct gatcgacctc     3600

caggagctgg gcaagtatga gcagtacatc aagtggccct ggtacatctg gctgggcttc     3660

atcgccggcc tgatcgccat cgtgatggtg accatcatgc tgtgctgtat gacatcctgc     3720

tgttcttgcc tgaagggctg ctgtagctgt ggctcctgct gtaagtttga cgaggatgac     3780

tctgaacctg tgctgaaggg cgtgaagctg cattacacct aa                        3822


<210>  24
<211>  1273
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Protein sequence of S-(deg-RBD) for Wuhan S-2P strain

<400>  24

Met Phe Val Phe Leu Val Leu Leu Pro Leu Val Ser Ser Gln Cys Val 
1               5                   10                  15      


Asn Leu Thr Thr Arg Thr Gln Leu Pro Pro Ala Tyr Thr Asn Ser Phe 
            20                  25                  30          


Thr Arg Gly Val Tyr Tyr Pro Asp Lys Val Phe Arg Ser Ser Val Leu 
        35                  40                  45              


His Ser Thr Gln Asp Leu Phe Leu Pro Phe Phe Ser Asn Val Thr Trp 
    50                  55                  60                  


Phe His Ala Ile His Val Ser Gly Thr Asn Gly Thr Lys Arg Phe Asp 
65                  70                  75                  80  


Asn Pro Val Leu Pro Phe Asn Asp Gly Val Tyr Phe Ala Ser Thr Glu 
                85                  90                  95      


Lys Ser Asn Ile Ile Arg Gly Trp Ile Phe Gly Thr Thr Leu Asp Ser 
            100                 105                 110         


Lys Thr Gln Ser Leu Leu Ile Val Asn Asn Ala Thr Asn Val Val Ile 
        115                 120                 125             


Lys Val Cys Glu Phe Gln Phe Cys Asn Asp Pro Phe Leu Gly Val Tyr 
    130                 135                 140                 


Tyr His Lys Asn Asn Lys Ser Trp Met Glu Ser Glu Phe Arg Val Tyr 
145                 150                 155                 160 


Ser Ser Ala Asn Asn Cys Thr Phe Glu Tyr Val Ser Gln Pro Phe Leu 
                165                 170                 175     


Met Asp Leu Glu Gly Lys Gln Gly Asn Phe Lys Asn Leu Arg Glu Phe 
            180                 185                 190         


Val Phe Lys Asn Ile Asp Gly Tyr Phe Lys Ile Tyr Ser Lys His Thr 
        195                 200                 205             


Pro Ile Asn Leu Val Arg Asp Leu Pro Gln Gly Phe Ser Ala Leu Glu 
    210                 215                 220                 


Pro Leu Val Asp Leu Pro Ile Gly Ile Asn Ile Thr Arg Phe Gln Thr 
225                 230                 235                 240 


Leu Leu Ala Leu His Arg Ser Tyr Leu Thr Pro Gly Asp Ser Ser Ser 
                245                 250                 255     


Gly Trp Thr Ala Gly Ala Ala Ala Tyr Tyr Val Gly Tyr Leu Gln Pro 
            260                 265                 270         


Arg Thr Phe Leu Leu Lys Tyr Asn Glu Asn Gly Thr Ile Thr Asp Ala 
        275                 280                 285             


Val Asp Cys Ala Leu Asp Pro Leu Ser Glu Thr Lys Cys Thr Leu Lys 
    290                 295                 300                 


Ser Phe Thr Val Glu Lys Gly Ile Tyr Gln Thr Ser Asn Phe Arg Val 
305                 310                 315                 320 


Gln Pro Ala Glu Ala Ile Val Arg Phe Pro Gln Ile Thr Asn Leu Cys 
                325                 330                 335     


Pro Phe Gly Glu Val Phe Gln Ala Thr Arg Phe Ala Ser Val Tyr Ala 
            340                 345                 350         


Trp Asn Arg Lys Arg Ile Ser Asn Cys Val Ala Asp Tyr Ser Val Leu 
        355                 360                 365             


Tyr Asn Ser Ala Ser Phe Ser Thr Phe Lys Cys Tyr Gly Val Ser Pro 
    370                 375                 380                 


Thr Lys Leu Asn Asp Leu Cys Phe Thr Asn Val Tyr Ala Asp Ser Phe 
385                 390                 395                 400 


Val Ile Arg Gly Asp Glu Val Arg Gln Ile Ala Pro Gly Gln Thr Gly 
                405                 410                 415     


Lys Ile Ala Asp Tyr Asn Tyr Lys Leu Pro Asp Asp Phe Thr Gly Cys 
            420                 425                 430         


Val Ile Ala Trp Asn Ser Asn Asn Leu Asp Ser Lys Val Gly Gly Asn 
        435                 440                 445             


Tyr Asn Tyr Leu Tyr Arg Leu Phe Arg Lys Ser Asn Leu Lys Pro Phe 
    450                 455                 460                 


Glu Arg Asp Ile Ser Thr Glu Ile Tyr Gln Ala Gly Ser Thr Pro Cys 
465                 470                 475                 480 


Asn Gly Val Glu Gly Phe Asn Cys Tyr Phe Pro Leu Gln Ser Tyr Gly 
                485                 490                 495     


Phe Gln Pro Thr Asn Gly Val Gly Tyr Gln Pro Tyr Arg Val Val Val 
            500                 505                 510         


Leu Ser Phe Glu Leu Leu His Ala Pro Ala Thr Val Cys Gly Pro Lys 
        515                 520                 525             


Lys Ser Thr Asn Leu Val Lys Asn Lys Cys Val Asn Phe Asn Phe Asn 
    530                 535                 540                 


Gly Leu Thr Gly Thr Gly Val Leu Thr Glu Ser Asn Lys Lys Phe Leu 
545                 550                 555                 560 


Pro Phe Gln Gln Phe Gly Arg Asp Ile Ala Asp Thr Thr Asp Ala Val 
                565                 570                 575     


Arg Asp Pro Gln Thr Leu Glu Ile Leu Asp Ile Thr Pro Cys Ser Phe 
            580                 585                 590         


Gly Gly Val Ser Val Ile Thr Pro Gly Thr Asn Thr Ser Asn Gln Val 
        595                 600                 605             


Ala Val Leu Tyr Gln Asp Val Asn Cys Thr Glu Val Pro Val Ala Ile 
    610                 615                 620                 


His Ala Asp Gln Leu Thr Pro Thr Trp Arg Val Tyr Ser Thr Gly Ser 
625                 630                 635                 640 


Asn Val Phe Gln Thr Arg Ala Gly Cys Leu Ile Gly Ala Glu His Val 
                645                 650                 655     


Asn Asn Ser Tyr Glu Cys Asp Ile Pro Ile Gly Ala Gly Ile Cys Ala 
            660                 665                 670         


Ser Tyr Gln Thr Gln Thr Asn Ser Pro Arg Arg Ala Arg Ser Val Ala 
        675                 680                 685             


Ser Gln Ser Ile Ile Ala Tyr Thr Met Ser Leu Gly Ala Glu Asn Ser 
    690                 695                 700                 


Val Ala Tyr Ser Asn Asn Ser Ile Ala Ile Pro Thr Asn Phe Thr Ile 
705                 710                 715                 720 


Ser Val Thr Thr Glu Ile Leu Pro Val Ser Met Thr Lys Thr Ser Val 
                725                 730                 735     


Asp Cys Thr Met Tyr Ile Cys Gly Asp Ser Thr Glu Cys Ser Asn Leu 
            740                 745                 750         


Leu Leu Gln Tyr Gly Ser Phe Cys Thr Gln Leu Asn Arg Ala Leu Thr 
        755                 760                 765             


Gly Ile Ala Val Glu Gln Asp Lys Asn Thr Gln Glu Val Phe Ala Gln 
    770                 775                 780                 


Val Lys Gln Ile Tyr Lys Thr Pro Pro Ile Lys Asp Phe Gly Gly Phe 
785                 790                 795                 800 


Asn Phe Ser Gln Ile Leu Pro Asp Pro Ser Lys Pro Ser Lys Arg Ser 
                805                 810                 815     


Phe Ile Glu Asp Leu Leu Phe Asn Lys Val Thr Leu Ala Asp Ala Gly 
            820                 825                 830         


Phe Ile Lys Gln Tyr Gly Asp Cys Leu Gly Asp Ile Ala Ala Arg Asp 
        835                 840                 845             


Leu Ile Cys Ala Gln Lys Phe Asn Gly Leu Thr Val Leu Pro Pro Leu 
    850                 855                 860                 


Leu Thr Asp Glu Met Ile Ala Gln Tyr Thr Ser Ala Leu Leu Ala Gly 
865                 870                 875                 880 


Thr Ile Thr Ser Gly Trp Thr Phe Gly Ala Gly Ala Ala Leu Gln Ile 
                885                 890                 895     


Pro Phe Ala Met Gln Met Ala Tyr Arg Phe Asn Gly Ile Gly Val Thr 
            900                 905                 910         


Gln Asn Val Leu Tyr Glu Asn Gln Lys Leu Ile Ala Asn Gln Phe Asn 
        915                 920                 925             


Ser Ala Ile Gly Lys Ile Gln Asp Ser Leu Ser Ser Thr Ala Ser Ala 
    930                 935                 940                 


Leu Gly Lys Leu Gln Asp Val Val Asn Gln Asn Ala Gln Ala Leu Asn 
945                 950                 955                 960 


Thr Leu Val Lys Gln Leu Ser Ser Asn Phe Gly Ala Ile Ser Ser Val 
                965                 970                 975     


Leu Asn Asp Ile Leu Ser Arg Leu Asp Pro Pro Glu Ala Glu Val Gln 
            980                 985                 990         


Ile Asp Arg Leu Ile Thr Gly Arg  Leu Gln Ser Leu Gln  Thr Tyr Val 
        995                 1000                 1005             


Thr Gln  Gln Leu Ile Arg Ala  Ala Glu Ile Arg Ala  Ser Ala Asn 
    1010                 1015                 1020             


Leu Ala  Ala Thr Lys Met Ser  Glu Cys Val Leu Gly  Gln Ser Lys 
    1025                 1030                 1035             


Arg Val  Asp Phe Cys Gly Lys  Gly Tyr His Leu Met  Ser Phe Pro 
    1040                 1045                 1050             


Gln Ser  Ala Pro His Gly Val  Val Phe Leu His Val  Thr Tyr Val 
    1055                 1060                 1065             


Pro Ala  Gln Glu Lys Asn Phe  Thr Thr Ala Pro Ala  Ile Cys His 
    1070                 1075                 1080             


Asp Gly  Lys Ala His Phe Pro  Arg Glu Gly Val Phe  Val Ser Asn 
    1085                 1090                 1095             


Gly Thr  His Trp Phe Val Thr  Gln Arg Asn Phe Tyr  Glu Pro Gln 
    1100                 1105                 1110             


Ile Ile  Thr Thr Asp Asn Thr  Phe Val Ser Gly Asn  Cys Asp Val 
    1115                 1120                 1125             


Val Ile  Gly Ile Val Asn Asn  Thr Val Tyr Asp Pro  Leu Gln Pro 
    1130                 1135                 1140             


Glu Leu  Asp Ser Phe Lys Glu  Glu Leu Asp Lys Tyr  Phe Lys Asn 
    1145                 1150                 1155             


His Thr  Ser Pro Asp Val Asp  Leu Gly Asp Ile Ser  Gly Ile Asn 
    1160                 1165                 1170             


Ala Ser  Val Val Asn Ile Gln  Lys Glu Ile Asp Arg  Leu Asn Glu 
    1175                 1180                 1185             


Val Ala  Lys Asn Leu Asn Glu  Ser Leu Ile Asp Leu  Gln Glu Leu 
    1190                 1195                 1200             


Gly Lys  Tyr Glu Gln Tyr Ile  Lys Trp Pro Trp Tyr  Ile Trp Leu 
    1205                 1210                 1215             


Gly Phe  Ile Ala Gly Leu Ile  Ala Ile Val Met Val  Thr Ile Met 
    1220                 1225                 1230             


Leu Cys  Cys Met Thr Ser Cys  Cys Ser Cys Leu Lys  Gly Cys Cys 
    1235                 1240                 1245             


Ser Cys  Gly Ser Cys Cys Lys  Phe Asp Glu Asp Asp  Ser Glu Pro 
    1250                 1255                 1260             


Val Leu  Lys Gly Val Lys Leu  His Tyr Thr 
    1265                 1270             


<210>  25
<211>  3816
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  S-(deg-RBD) for Delta S-2P strain

<400>  25
atgttcgtct tcctggtcct gctgcctctg gtctcctcac agtgcgtcaa tctgcgaact       60

cggactcagc tgccacctgc ttatactaat agcttcacca gaggcgtgta ctatcctgac      120

aaggtgttta gaagctccgt gctgcactct acacaggatc tgtttctgcc attctttagc      180

aacgtgacct ggttccacgc catccacgtg agcggcacca atggcacaaa gcggttcgac      240

aatcccgtgc tgccttttaa cgatggcgtg tacttcgcct ctatcgagaa gagcaacatc      300

atcagaggct ggatctttgg caccacactg gactccaaga cacagtctct gctgatcgtg      360

aacaatgcca ccaacgtggt catcaaggtg tgcgagttcc agttttgtaa tgatcccttc      420

ctggacgtgt actatcacaa gaacaataag agctggatgg agtccggagt gtattctagc      480

gccaacaact gcacatttga gtacgtgagc cagcctttcc tgatggacct ggagggcaag      540

cagggcaatt tcaagaacct gagggagttc gtgtttaaga atatcgacgg ctacttcaaa      600

atctactcta agcacacccc catcaacctg gtgcgcgacc tgcctcaggg cttcagcgcc      660

ctggagcccc tggtggatct gcctatcggc atcaacatca cccggtttca gacactgctg      720

gccctgcaca gaagctacct gacacccggc gactcctcta gcggatggac cgccggcgct      780

gccgcctact atgtgggcta cctccagccc cggaccttcc tgctgaagta caacgagaat      840

ggcaccatca cagacgcagt ggattgcgcc ctggaccccc tgagcgagac aaagtgtaca      900

ctgaagtcct ttaccgtgga gaagggcatc tatcagacat ccaatttcag ggtgcagcca      960

gccgaggcga tcgtgcgctt tcctgaaatc acaaacctgt gcccatttgg cgaggtgttc     1020

gaggcaaccc gcttcgccag cgtgtacgcc tggaatagga agcggatcag caactgcgtg     1080

gccgactata gcgtgctgta caactccgcc tctttcagca cctttaagtg ctatggcgtg     1140

tcccccacaa agctgaatga cctgtgcttt accaacgtct acgccgattc tttcgtgatc     1200

aggggcgacg aggtgcgcca gatcgccccc ggccagacag gcaagatcgc agactacaat     1260

tataagctgc cagacgattt caccggctgc gtgatcgcct ggaacagcaa caatctggat     1320

tccaaagtgg gcggcaacta caattatcgg taccggctgt ttagaaagag caatctgaag     1380

cccttcgaga gggacatctc tacagaaatc taccaggccg gcagcaagcc ttgcaatggc     1440

gtggagggct ttaactgtta tttcccactc cagtcctacg gcttccagcc cacaaacggc     1500

gtgggctatc agccttaccg cgtggtggtg ctgagctttg agctgctgca cgccccagca     1560

acagtgtgcg gccccaagaa gtccaccaat ctggtgaaga acaagtgcgt gaacttcaac     1620

ttcaacggcc tgaccggcac aggcgtgctg accgagtcca acaagaagtt cctgccattt     1680

cagcagttcg gcagggacat cgcagatacc acagacgccg tgcgcgaccc acagaccctg     1740

gagatcctgg acatcacacc ctgctctttc ggcggcgtga gcgtgatcac acccggcacc     1800

aatacaagca accaggtggc cgtgctgtat cagggcgtga attgtaccga ggtgcccgtg     1860

gctatccacg ccgatcagct gaccccaaca tggcgggtgt acagcaccgg ctccaacgtc     1920

ttccagacaa gagccggatg cctgatcgga gcagagcacg tgaacaattc ctatgagtgc     1980

gacatcccaa tcggcgccgg catctgtgcc tcttaccaga cccagacaaa ctctcgcaga     2040

agagcccgga gcgtggcctc ccagtctatc atcgcctata ccatgtccct gggcgccgag     2100

aacagcgtgg cctactctaa caatagcatc gccatcccaa ccaacttcac aatctctgtg     2160

accacagaga tcctgcccgt gtccatgacc aagacatctg tggactgcac aatgtatatc     2220

tgtggcgatt ctaccgagtg cagcaacctg ctgctccagt acggcagctt ttgtacccag     2280

ctgaatagag ccctgacagg catcgccgtg gagcaggata agaacacaca ggaggtgttc     2340

gcccaggtga agcaaatcta caagaccccc cctatcaagg actttggcgg cttcaatttt     2400

tcccagatcc tgcctgatcc atccaagcct tctaagcgga gctttatcga ggacctgctg     2460

ttcaacaagg tgaccctggc cgatgccggc ttcatcaagc agtatggcga ttgcctgggc     2520

gacatcgcag ccagggacct gatctgcgcc cagaagttta atggcctgac cgtgctgcca     2580

cccctgctga cagatgagat gatcgcacag tacacaagcg ccctgctggc cggcaccatc     2640

acatccggat ggaccttcgg cgcaggagcc gccctccaga tcccctttgc catgcagatg     2700

gcctataggt tcaacggcat cggcgtgacc cagaatgtgc tgtacgagaa ccagaagctg     2760

atcgccaatc agtttaactc cgccatcggc aagatccagg acagcctgtc ctctacagcc     2820

agcgccctgg gcaagctcca gaatgtggtg aatcagaacg cccaggccct gaataccctg     2880

gtgaagcagc tgagcagcaa cttcggcgcc atctctagcg tgctgaatga catcctgagc     2940

cggctggacc cgccggaggc agaggtgcag atcgaccggc tgatcaccgg ccggctccag     3000

agcctccaga cctatgtgac acagcagctg atcagggccg ccgagatcag ggccagcgcc     3060

aatctggcag caaccaagat gtccgagtgc gtgctgggcc agtctaagag agtggacttt     3120

tgtggcaagg gctatcacct gatgtccttc cctcagtctg ccccacacgg cgtggtgttt     3180

ctgcacgtga cctacgtgcc cgcccaggag aagaacttca ccacagcccc tgccatctgc     3240

cacgatggca aggcccactt tccaagggag ggcgtgttcg tgtccaacgg cacccactgg     3300

tttgtgacac agcgcaattt ctacgagccc cagatcatca ccacagacaa caccttcgtg     3360

agcggcaact gtgacgtggt catcggcatc gtgaacaata ccgtgtatga tccactccag     3420

cccgagctgg acagctttaa ggaggagctg gataagtatt tcaagaatca cacctcccct     3480

gacgtggatc tgggcgacat cagcggcatc aatgcctccg tggtgaacat ccagaaggag     3540

atcgaccgcc tgaacgaggt ggctaagaat ctgaacgaga gcctgatcga cctccaggag     3600

ctgggcaagt atgagcagta catcaagtgg ccctggtaca tctggctggg cttcatcgcc     3660

ggcctgatcg ccatcgtgat ggtgaccatc atgctgtgct gtatgacatc ctgctgttct     3720

tgcctgaagg gctgctgtag ctgtggctcc tgctgtaagt ttgacgagga tgactctgaa     3780

cctgtgctga agggcgtgaa gctgcattac acctaa                               3816


<210>  26
<211>  1271
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  S-(deg-RBD) for Delta S-2P strain

<400>  26

Met Phe Val Phe Leu Val Leu Leu Pro Leu Val Ser Ser Gln Cys Val 
1               5                   10                  15      


Asn Leu Arg Thr Arg Thr Gln Leu Pro Pro Ala Tyr Thr Asn Ser Phe 
            20                  25                  30          


Thr Arg Gly Val Tyr Tyr Pro Asp Lys Val Phe Arg Ser Ser Val Leu 
        35                  40                  45              


His Ser Thr Gln Asp Leu Phe Leu Pro Phe Phe Ser Asn Val Thr Trp 
    50                  55                  60                  


Phe His Ala Ile His Val Ser Gly Thr Asn Gly Thr Lys Arg Phe Asp 
65                  70                  75                  80  


Asn Pro Val Leu Pro Phe Asn Asp Gly Val Tyr Phe Ala Ser Ile Glu 
                85                  90                  95      


Lys Ser Asn Ile Ile Arg Gly Trp Ile Phe Gly Thr Thr Leu Asp Ser 
            100                 105                 110         


Lys Thr Gln Ser Leu Leu Ile Val Asn Asn Ala Thr Asn Val Val Ile 
        115                 120                 125             


Lys Val Cys Glu Phe Gln Phe Cys Asn Asp Pro Phe Leu Asp Val Tyr 
    130                 135                 140                 


Tyr His Lys Asn Asn Lys Ser Trp Met Glu Ser Gly Val Tyr Ser Ser 
145                 150                 155                 160 


Ala Asn Asn Cys Thr Phe Glu Tyr Val Ser Gln Pro Phe Leu Met Asp 
                165                 170                 175     


Leu Glu Gly Lys Gln Gly Asn Phe Lys Asn Leu Arg Glu Phe Val Phe 
            180                 185                 190         


Lys Asn Ile Asp Gly Tyr Phe Lys Ile Tyr Ser Lys His Thr Pro Ile 
        195                 200                 205             


Asn Leu Val Arg Asp Leu Pro Gln Gly Phe Ser Ala Leu Glu Pro Leu 
    210                 215                 220                 


Val Asp Leu Pro Ile Gly Ile Asn Ile Thr Arg Phe Gln Thr Leu Leu 
225                 230                 235                 240 


Ala Leu His Arg Ser Tyr Leu Thr Pro Gly Asp Ser Ser Ser Gly Trp 
                245                 250                 255     


Thr Ala Gly Ala Ala Ala Tyr Tyr Val Gly Tyr Leu Gln Pro Arg Thr 
            260                 265                 270         


Phe Leu Leu Lys Tyr Asn Glu Asn Gly Thr Ile Thr Asp Ala Val Asp 
        275                 280                 285             


Cys Ala Leu Asp Pro Leu Ser Glu Thr Lys Cys Thr Leu Lys Ser Phe 
    290                 295                 300                 


Thr Val Glu Lys Gly Ile Tyr Gln Thr Ser Asn Phe Arg Val Gln Pro 
305                 310                 315                 320 


Ala Glu Ala Ile Val Arg Phe Pro Gln Ile Thr Asn Leu Cys Pro Phe 
                325                 330                 335     


Gly Glu Val Phe Gln Ala Thr Arg Phe Ala Ser Val Tyr Ala Trp Asn 
            340                 345                 350         


Arg Lys Arg Ile Ser Asn Cys Val Ala Asp Tyr Ser Val Leu Tyr Asn 
        355                 360                 365             


Ser Ala Ser Phe Ser Thr Phe Lys Cys Tyr Gly Val Ser Pro Thr Lys 
    370                 375                 380                 


Leu Asn Asp Leu Cys Phe Thr Asn Val Tyr Ala Asp Ser Phe Val Ile 
385                 390                 395                 400 


Arg Gly Asp Glu Val Arg Gln Ile Ala Pro Gly Gln Thr Gly Lys Ile 
                405                 410                 415     


Ala Asp Tyr Asn Tyr Lys Leu Pro Asp Asp Phe Thr Gly Cys Val Ile 
            420                 425                 430         


Ala Trp Asn Ser Asn Asn Leu Asp Ser Lys Val Gly Gly Asn Tyr Asn 
        435                 440                 445             


Tyr Arg Tyr Arg Leu Phe Arg Lys Ser Asn Leu Lys Pro Phe Glu Arg 
    450                 455                 460                 


Asp Ile Ser Thr Glu Ile Tyr Gln Ala Gly Ser Lys Pro Cys Asn Gly 
465                 470                 475                 480 


Val Glu Gly Phe Asn Cys Tyr Phe Pro Leu Gln Ser Tyr Gly Phe Gln 
                485                 490                 495     


Pro Thr Asn Gly Val Gly Tyr Gln Pro Tyr Arg Val Val Val Leu Ser 
            500                 505                 510         


Phe Glu Leu Leu His Ala Pro Ala Thr Val Cys Gly Pro Lys Lys Ser 
        515                 520                 525             


Thr Asn Leu Val Lys Asn Lys Cys Val Asn Phe Asn Phe Asn Gly Leu 
    530                 535                 540                 


Thr Gly Thr Gly Val Leu Thr Glu Ser Asn Lys Lys Phe Leu Pro Phe 
545                 550                 555                 560 


Gln Gln Phe Gly Arg Asp Ile Ala Asp Thr Thr Asp Ala Val Arg Asp 
                565                 570                 575     


Pro Gln Thr Leu Glu Ile Leu Asp Ile Thr Pro Cys Ser Phe Gly Gly 
            580                 585                 590         


Val Ser Val Ile Thr Pro Gly Thr Asn Thr Ser Asn Gln Val Ala Val 
        595                 600                 605             


Leu Tyr Gln Gly Val Asn Cys Thr Glu Val Pro Val Ala Ile His Ala 
    610                 615                 620                 


Asp Gln Leu Thr Pro Thr Trp Arg Val Tyr Ser Thr Gly Ser Asn Val 
625                 630                 635                 640 


Phe Gln Thr Arg Ala Gly Cys Leu Ile Gly Ala Glu His Val Asn Asn 
                645                 650                 655     


Ser Tyr Glu Cys Asp Ile Pro Ile Gly Ala Gly Ile Cys Ala Ser Tyr 
            660                 665                 670         


Gln Thr Gln Thr Asn Ser Arg Arg Arg Ala Arg Ser Val Ala Ser Gln 
        675                 680                 685             


Ser Ile Ile Ala Tyr Thr Met Ser Leu Gly Ala Glu Asn Ser Val Ala 
    690                 695                 700                 


Tyr Ser Asn Asn Ser Ile Ala Ile Pro Thr Asn Phe Thr Ile Ser Val 
705                 710                 715                 720 


Thr Thr Glu Ile Leu Pro Val Ser Met Thr Lys Thr Ser Val Asp Cys 
                725                 730                 735     


Thr Met Tyr Ile Cys Gly Asp Ser Thr Glu Cys Ser Asn Leu Leu Leu 
            740                 745                 750         


Gln Tyr Gly Ser Phe Cys Thr Gln Leu Asn Arg Ala Leu Thr Gly Ile 
        755                 760                 765             


Ala Val Glu Gln Asp Lys Asn Thr Gln Glu Val Phe Ala Gln Val Lys 
    770                 775                 780                 


Gln Ile Tyr Lys Thr Pro Pro Ile Lys Asp Phe Gly Gly Phe Asn Phe 
785                 790                 795                 800 


Ser Gln Ile Leu Pro Asp Pro Ser Lys Pro Ser Lys Arg Ser Phe Ile 
                805                 810                 815     


Glu Asp Leu Leu Phe Asn Lys Val Thr Leu Ala Asp Ala Gly Phe Ile 
            820                 825                 830         


Lys Gln Tyr Gly Asp Cys Leu Gly Asp Ile Ala Ala Arg Asp Leu Ile 
        835                 840                 845             


Cys Ala Gln Lys Phe Asn Gly Leu Thr Val Leu Pro Pro Leu Leu Thr 
    850                 855                 860                 


Asp Glu Met Ile Ala Gln Tyr Thr Ser Ala Leu Leu Ala Gly Thr Ile 
865                 870                 875                 880 


Thr Ser Gly Trp Thr Phe Gly Ala Gly Ala Ala Leu Gln Ile Pro Phe 
                885                 890                 895     


Ala Met Gln Met Ala Tyr Arg Phe Asn Gly Ile Gly Val Thr Gln Asn 
            900                 905                 910         


Val Leu Tyr Glu Asn Gln Lys Leu Ile Ala Asn Gln Phe Asn Ser Ala 
        915                 920                 925             


Ile Gly Lys Ile Gln Asp Ser Leu Ser Ser Thr Ala Ser Ala Leu Gly 
    930                 935                 940                 


Lys Leu Gln Asn Val Val Asn Gln Asn Ala Gln Ala Leu Asn Thr Leu 
945                 950                 955                 960 


Val Lys Gln Leu Ser Ser Asn Phe Gly Ala Ile Ser Ser Val Leu Asn 
                965                 970                 975     


Asp Ile Leu Ser Arg Leu Asp Pro Pro Glu Ala Glu Val Gln Ile Asp 
            980                 985                 990         


Arg Leu Ile Thr Gly Arg Leu Gln  Ser Leu Gln Thr Tyr  Val Thr Gln 
        995                 1000                 1005             


Gln Leu  Ile Arg Ala Ala Glu  Ile Arg Ala Ser Ala  Asn Leu Ala 
    1010                 1015                 1020             


Ala Thr  Lys Met Ser Glu Cys  Val Leu Gly Gln Ser  Lys Arg Val 
    1025                 1030                 1035             


Asp Phe  Cys Gly Lys Gly Tyr  His Leu Met Ser Phe  Pro Gln Ser 
    1040                 1045                 1050             


Ala Pro  His Gly Val Val Phe  Leu His Val Thr Tyr  Val Pro Ala 
    1055                 1060                 1065             


Gln Glu  Lys Asn Phe Thr Thr  Ala Pro Ala Ile Cys  His Asp Gly 
    1070                 1075                 1080             


Lys Ala  His Phe Pro Arg Glu  Gly Val Phe Val Ser  Asn Gly Thr 
    1085                 1090                 1095             


His Trp  Phe Val Thr Gln Arg  Asn Phe Tyr Glu Pro  Gln Ile Ile 
    1100                 1105                 1110             


Thr Thr  Asp Asn Thr Phe Val  Ser Gly Asn Cys Asp  Val Val Ile 
    1115                 1120                 1125             


Gly Ile  Val Asn Asn Thr Val  Tyr Asp Pro Leu Gln  Pro Glu Leu 
    1130                 1135                 1140             


Asp Ser  Phe Lys Glu Glu Leu  Asp Lys Tyr Phe Lys  Asn His Thr 
    1145                 1150                 1155             


Ser Pro  Asp Val Asp Leu Gly  Asp Ile Ser Gly Ile  Asn Ala Ser 
    1160                 1165                 1170             


Val Val  Asn Ile Gln Lys Glu  Ile Asp Arg Leu Asn  Glu Val Ala 
    1175                 1180                 1185             


Lys Asn  Leu Asn Glu Ser Leu  Ile Asp Leu Gln Glu  Leu Gly Lys 
    1190                 1195                 1200             


Tyr Glu  Gln Tyr Ile Lys Trp  Pro Trp Tyr Ile Trp  Leu Gly Phe 
    1205                 1210                 1215             


Ile Ala  Gly Leu Ile Ala Ile  Val Met Val Thr Ile  Met Leu Cys 
    1220                 1225                 1230             


Cys Met  Thr Ser Cys Cys Ser  Cys Leu Lys Gly Cys  Cys Ser Cys 
    1235                 1240                 1245             


Gly Ser  Cys Cys Lys Phe Asp  Glu Asp Asp Ser Glu  Pro Val Leu 
    1250                 1255                 1260             


Lys Gly  Val Lys Leu His Tyr  Thr 
    1265                 1270     


<210>  27
<211>  3816
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  S-(deg-S2) for Delta strain

<400>  27
atgttcgtct tcctggtcct gctgcctctg gtctcctcac agtgcgtcaa tctgcgaact       60

cggactcagc tgccacctgc ttatactaat agcttcacca gaggcgtgta ctatcctgac      120

aaggtgttta gaagctccgt gctgcactct acacaggatc tgtttctgcc attctttagc      180

aacgtgacct ggttccacgc catccacgtg agcggcacca atggcacaaa gcggttcgac      240

aatcccgtgc tgccttttaa cgatggcgtg tacttcgcct ctatcgagaa gagcaacatc      300

atcagaggct ggatctttgg caccacactg gactccaaga cacagtctct gctgatcgtg      360

aacaatgcca ccaacgtggt catcaaggtg tgcgagttcc agttttgtaa tgatcccttc      420

ctggacgtgt actatcacaa gaacaataag agctggatgg agtccggagt gtattctagc      480

gccaacaact gcacatttga gtacgtgagc cagcctttcc tgatggacct ggagggcaag      540

cagggcaatt tcaagaacct gagggagttc gtgtttaaga atatcgacgg ctacttcaaa      600

atctactcta agcacacccc catcaacctg gtgcgcgacc tgcctcaggg cttcagcgcc      660

ctggagcccc tggtggatct gcctatcggc atcaacatca cccggtttca gacactgctg      720

gccctgcaca gaagctacct gacacccggc gactcctcta gcggatggac cgccggcgct      780

gccgcctact atgtgggcta cctccagccc cggaccttcc tgctgaagta caacgagaat      840

ggcaccatca cagacgcagt ggattgcgcc ctggaccccc tgagcgagac aaagtgtaca      900

ctgaagtcct ttaccgtgga gaagggcatc tatcagacat ccaatttcag ggtgcagcca      960

accgagtcta tcgtgcgctt tcctaatatc acaaacctgt gcccatttgg cgaggtgttc     1020

aacgcaaccc gcttcgccag cgtgtacgcc tggaatagga agcggatcag caactgcgtg     1080

gccgactata gcgtgctgta caactccgcc tctttcagca cctttaagtg ctatggcgtg     1140

tcccccacaa agctgaatga cctgtgcttt accaacgtct acgccgattc tttcgtgatc     1200

aggggcgacg aggtgcgcca gatcgccccc ggccagacag gcaagatcgc agactacaat     1260

tataagctgc cagacgattt caccggctgc gtgatcgcct ggaacagcaa caatctggat     1320

tccaaagtgg gcggcaacta caattatcgg taccggctgt ttagaaagag caatctgaag     1380

cccttcgaga gggacatctc tacagaaatc taccaggccg gcagcaagcc ttgcaatggc     1440

gtggagggct ttaactgtta tttcccactc cagtcctacg gcttccagcc cacaaacggc     1500

gtgggctatc agccttaccg cgtggtggtg ctgagctttg agctgctgca cgccccagca     1560

acagtgtgcg gccccaagaa gtccaccaat ctggtgaaga acaagtgcgt gaacttcaac     1620

ttcaacggcc tgaccggcac aggcgtgctg accgagtcca acaagaagtt cctgccattt     1680

cagcagttcg gcagggacat cgcagatacc acagacgccg tgcgcgaccc acagaccctg     1740

gagatcctgg acatcacacc ctgctctttc ggcggcgtga gcgtgatcac acccggcacc     1800

aatacaagca accaggtggc cgtgctgtat cagggcgtga attgtaccga ggtgcccgtg     1860

gctatccacg ccgatcagct gaccccaaca tggcgggtgt acagcaccgg ctccaacgtc     1920

ttccagacaa gagccggatg cctgatcgga gcagagcacg tgaacaattc ctatgagtgc     1980

gacatcccaa tcggcgccgg catctgtgcc tcttaccaga cccagacaaa ctctcgcaga     2040

agagcccgga gcgtggcctc ccagtctatc atcgcctata ccatgtccct gggcgccgag     2100

aacagcgtgg cctactctca gaatagcatc gccatcccaa cccagttcac aatctctgtg     2160

accacagaga tcctgcccgt gtccatgacc aagacatctg tggactgcac aatgtatatc     2220

tgtggcgatt ctaccgagtg cagcaacctg ctgctccagt acggcagctt ttgtacccag     2280

ctgaatagag ccctgacagg catcgccgtg gagcaggata agaacacaca ggaggtgttc     2340

gcccaggtga agcaaatcta caagaccccc cctatcaagg actttggcgg cttccaattt     2400

tcccagatcc tgcctgatcc atccaagcct tctaagcgga gctttatcga ggacctgctg     2460

ttcaacaagg tgaccctggc cgatgccggc ttcatcaagc agtatggcga ttgcctgggc     2520

gacatcgcag ccagggacct gatctgcgcc cagaagttta atggcctgac cgtgctgcca     2580

cccctgctga cagatgagat gatcgcacag tacacaagcg ccctgctggc cggcaccatc     2640

acatccggat ggaccttcgg cgcaggagcc gccctccaga tcccctttgc catgcagatg     2700

gcctataggt tcaacggcat cggcgtgacc cagaatgtgc tgtacgagaa ccagaagctg     2760

atcgccaatc agtttaactc cgccatcggc aagatccagg acagcctgtc ctctacagcc     2820

agcgccctgg gcaagctcca gaatgtggtg aatcagaacg cccaggccct gaataccctg     2880

gtgaagcagc tgagcagcaa cttcggcgcc atctctagcg tgctgaatga catcctgagc     2940

cggctggaca aggtggaggc agaggtgcag atcgaccggc tgatcaccgg ccggctccag     3000

agcctccaga cctatgtgac acagcagctg atcagggccg ccgagatcag ggccagcgcc     3060

aatctggcag caaccaagat gtccgagtgc gtgctgggcc agtctaagag agtggacttt     3120

tgtggcaagg gctatcacct gatgtccttc cctcagtctg ccccacacgg cgtggtgttt     3180

ctgcacgtga cctacgtgcc cgcccaggag aagcagttca ccacagcccc tgccatctgc     3240

cacgatggca aggcccactt tccaagggag ggcgtgttcg tgtcccaggg cacccactgg     3300

tttgtgacac agcgcaattt ctacgagccc cagatcatca ccacagacaa caccttcgtg     3360

agcggcaact gtgacgtggt catcggcatc gtgcagaata ccgtgtatga tccactccag     3420

cccgagctgg acagctttaa ggaggagctg gataagtatt tcaagcaaca cacctcccct     3480

gacgtggatc tgggcgacat cagcggcatc caagcctccg tggtgaacat ccagaaggag     3540

atcgaccgcc tgaacgaggt ggctaagaat ctgcaggaga gcctgatcga cctccaggag     3600

ctgggcaagt atgagcagta catcaagtgg ccctggtaca tctggctggg cttcatcgcc     3660

ggcctgatcg ccatcgtgat ggtgaccatc atgctgtgct gtatgacatc ctgctgttct     3720

tgcctgaagg gctgctgtag ctgtggctcc tgctgtaagt ttgacgagga tgactctgaa     3780

cctgtgctga agggcgtgaa gctgcattac acctaa                               3816


<210>  28
<211>  1271
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  S-(deg-S2) for Delta strain

<400>  28

Met Phe Val Phe Leu Val Leu Leu Pro Leu Val Ser Ser Gln Cys Val 
1               5                   10                  15      


Asn Leu Arg Thr Arg Thr Gln Leu Pro Pro Ala Tyr Thr Asn Ser Phe 
            20                  25                  30          


Thr Arg Gly Val Tyr Tyr Pro Asp Lys Val Phe Arg Ser Ser Val Leu 
        35                  40                  45              


His Ser Thr Gln Asp Leu Phe Leu Pro Phe Phe Ser Asn Val Thr Trp 
    50                  55                  60                  


Phe His Ala Ile His Val Ser Gly Thr Asn Gly Thr Lys Arg Phe Asp 
65                  70                  75                  80  


Asn Pro Val Leu Pro Phe Asn Asp Gly Val Tyr Phe Ala Ser Ile Glu 
                85                  90                  95      


Lys Ser Asn Ile Ile Arg Gly Trp Ile Phe Gly Thr Thr Leu Asp Ser 
            100                 105                 110         


Lys Thr Gln Ser Leu Leu Ile Val Asn Asn Ala Thr Asn Val Val Ile 
        115                 120                 125             


Lys Val Cys Glu Phe Gln Phe Cys Asn Asp Pro Phe Leu Asp Val Tyr 
    130                 135                 140                 


Tyr His Lys Asn Asn Lys Ser Trp Met Glu Ser Gly Val Tyr Ser Ser 
145                 150                 155                 160 


Ala Asn Asn Cys Thr Phe Glu Tyr Val Ser Gln Pro Phe Leu Met Asp 
                165                 170                 175     


Leu Glu Gly Lys Gln Gly Asn Phe Lys Asn Leu Arg Glu Phe Val Phe 
            180                 185                 190         


Lys Asn Ile Asp Gly Tyr Phe Lys Ile Tyr Ser Lys His Thr Pro Ile 
        195                 200                 205             


Asn Leu Val Arg Asp Leu Pro Gln Gly Phe Ser Ala Leu Glu Pro Leu 
    210                 215                 220                 


Val Asp Leu Pro Ile Gly Ile Asn Ile Thr Arg Phe Gln Thr Leu Leu 
225                 230                 235                 240 


Ala Leu His Arg Ser Tyr Leu Thr Pro Gly Asp Ser Ser Ser Gly Trp 
                245                 250                 255     


Thr Ala Gly Ala Ala Ala Tyr Tyr Val Gly Tyr Leu Gln Pro Arg Thr 
            260                 265                 270         


Phe Leu Leu Lys Tyr Asn Glu Asn Gly Thr Ile Thr Asp Ala Val Asp 
        275                 280                 285             


Cys Ala Leu Asp Pro Leu Ser Glu Thr Lys Cys Thr Leu Lys Ser Phe 
    290                 295                 300                 


Thr Val Glu Lys Gly Ile Tyr Gln Thr Ser Asn Phe Arg Val Gln Pro 
305                 310                 315                 320 


Thr Glu Ser Ile Val Arg Phe Pro Asn Ile Thr Asn Leu Cys Pro Phe 
                325                 330                 335     


Gly Glu Val Phe Asn Ala Thr Arg Phe Ala Ser Val Tyr Ala Trp Asn 
            340                 345                 350         


Arg Lys Arg Ile Ser Asn Cys Val Ala Asp Tyr Ser Val Leu Tyr Asn 
        355                 360                 365             


Ser Ala Ser Phe Ser Thr Phe Lys Cys Tyr Gly Val Ser Pro Thr Lys 
    370                 375                 380                 


Leu Asn Asp Leu Cys Phe Thr Asn Val Tyr Ala Asp Ser Phe Val Ile 
385                 390                 395                 400 


Arg Gly Asp Glu Val Arg Gln Ile Ala Pro Gly Gln Thr Gly Lys Ile 
                405                 410                 415     


Ala Asp Tyr Asn Tyr Lys Leu Pro Asp Asp Phe Thr Gly Cys Val Ile 
            420                 425                 430         


Ala Trp Asn Ser Asn Asn Leu Asp Ser Lys Val Gly Gly Asn Tyr Asn 
        435                 440                 445             


Tyr Arg Tyr Arg Leu Phe Arg Lys Ser Asn Leu Lys Pro Phe Glu Arg 
    450                 455                 460                 


Asp Ile Ser Thr Glu Ile Tyr Gln Ala Gly Ser Lys Pro Cys Asn Gly 
465                 470                 475                 480 


Val Glu Gly Phe Asn Cys Tyr Phe Pro Leu Gln Ser Tyr Gly Phe Gln 
                485                 490                 495     


Pro Thr Asn Gly Val Gly Tyr Gln Pro Tyr Arg Val Val Val Leu Ser 
            500                 505                 510         


Phe Glu Leu Leu His Ala Pro Ala Thr Val Cys Gly Pro Lys Lys Ser 
        515                 520                 525             


Thr Asn Leu Val Lys Asn Lys Cys Val Asn Phe Asn Phe Asn Gly Leu 
    530                 535                 540                 


Thr Gly Thr Gly Val Leu Thr Glu Ser Asn Lys Lys Phe Leu Pro Phe 
545                 550                 555                 560 


Gln Gln Phe Gly Arg Asp Ile Ala Asp Thr Thr Asp Ala Val Arg Asp 
                565                 570                 575     


Pro Gln Thr Leu Glu Ile Leu Asp Ile Thr Pro Cys Ser Phe Gly Gly 
            580                 585                 590         


Val Ser Val Ile Thr Pro Gly Thr Asn Thr Ser Asn Gln Val Ala Val 
        595                 600                 605             


Leu Tyr Gln Gly Val Asn Cys Thr Glu Val Pro Val Ala Ile His Ala 
    610                 615                 620                 


Asp Gln Leu Thr Pro Thr Trp Arg Val Tyr Ser Thr Gly Ser Asn Val 
625                 630                 635                 640 


Phe Gln Thr Arg Ala Gly Cys Leu Ile Gly Ala Glu His Val Asn Asn 
                645                 650                 655     


Ser Tyr Glu Cys Asp Ile Pro Ile Gly Ala Gly Ile Cys Ala Ser Tyr 
            660                 665                 670         


Gln Thr Gln Thr Asn Ser Arg Arg Arg Ala Arg Ser Val Ala Ser Gln 
        675                 680                 685             


Ser Ile Ile Ala Tyr Thr Met Ser Leu Gly Ala Glu Asn Ser Val Ala 
    690                 695                 700                 


Tyr Ser Gln Asn Ser Ile Ala Ile Pro Thr Gln Phe Thr Ile Ser Val 
705                 710                 715                 720 


Thr Thr Glu Ile Leu Pro Val Ser Met Thr Lys Thr Ser Val Asp Cys 
                725                 730                 735     


Thr Met Tyr Ile Cys Gly Asp Ser Thr Glu Cys Ser Asn Leu Leu Leu 
            740                 745                 750         


Gln Tyr Gly Ser Phe Cys Thr Gln Leu Asn Arg Ala Leu Thr Gly Ile 
        755                 760                 765             


Ala Val Glu Gln Asp Lys Asn Thr Gln Glu Val Phe Ala Gln Val Lys 
    770                 775                 780                 


Gln Ile Tyr Lys Thr Pro Pro Ile Lys Asp Phe Gly Gly Phe Gln Phe 
785                 790                 795                 800 


Ser Gln Ile Leu Pro Asp Pro Ser Lys Pro Ser Lys Arg Ser Phe Ile 
                805                 810                 815     


Glu Asp Leu Leu Phe Asn Lys Val Thr Leu Ala Asp Ala Gly Phe Ile 
            820                 825                 830         


Lys Gln Tyr Gly Asp Cys Leu Gly Asp Ile Ala Ala Arg Asp Leu Ile 
        835                 840                 845             


Cys Ala Gln Lys Phe Asn Gly Leu Thr Val Leu Pro Pro Leu Leu Thr 
    850                 855                 860                 


Asp Glu Met Ile Ala Gln Tyr Thr Ser Ala Leu Leu Ala Gly Thr Ile 
865                 870                 875                 880 


Thr Ser Gly Trp Thr Phe Gly Ala Gly Ala Ala Leu Gln Ile Pro Phe 
                885                 890                 895     


Ala Met Gln Met Ala Tyr Arg Phe Asn Gly Ile Gly Val Thr Gln Asn 
            900                 905                 910         


Val Leu Tyr Glu Asn Gln Lys Leu Ile Ala Asn Gln Phe Asn Ser Ala 
        915                 920                 925             


Ile Gly Lys Ile Gln Asp Ser Leu Ser Ser Thr Ala Ser Ala Leu Gly 
    930                 935                 940                 


Lys Leu Gln Asn Val Val Asn Gln Asn Ala Gln Ala Leu Asn Thr Leu 
945                 950                 955                 960 


Val Lys Gln Leu Ser Ser Asn Phe Gly Ala Ile Ser Ser Val Leu Asn 
                965                 970                 975     


Asp Ile Leu Ser Arg Leu Asp Lys Val Glu Ala Glu Val Gln Ile Asp 
            980                 985                 990         


Arg Leu Ile Thr Gly Arg Leu Gln  Ser Leu Gln Thr Tyr  Val Thr Gln 
        995                 1000                 1005             


Gln Leu  Ile Arg Ala Ala Glu  Ile Arg Ala Ser Ala  Asn Leu Ala 
    1010                 1015                 1020             


Ala Thr  Lys Met Ser Glu Cys  Val Leu Gly Gln Ser  Lys Arg Val 
    1025                 1030                 1035             


Asp Phe  Cys Gly Lys Gly Tyr  His Leu Met Ser Phe  Pro Gln Ser 
    1040                 1045                 1050             


Ala Pro  His Gly Val Val Phe  Leu His Val Thr Tyr  Val Pro Ala 
    1055                 1060                 1065             


Gln Glu  Lys Gln Phe Thr Thr  Ala Pro Ala Ile Cys  His Asp Gly 
    1070                 1075                 1080             


Lys Ala  His Phe Pro Arg Glu  Gly Val Phe Val Ser  Gln Gly Thr 
    1085                 1090                 1095             


His Trp  Phe Val Thr Gln Arg  Asn Phe Tyr Glu Pro  Gln Ile Ile 
    1100                 1105                 1110             


Thr Thr  Asp Asn Thr Phe Val  Ser Gly Asn Cys Asp  Val Val Ile 
    1115                 1120                 1125             


Gly Ile  Val Gln Asn Thr Val  Tyr Asp Pro Leu Gln  Pro Glu Leu 
    1130                 1135                 1140             


Asp Ser  Phe Lys Glu Glu Leu  Asp Lys Tyr Phe Lys  Gln His Thr 
    1145                 1150                 1155             


Ser Pro  Asp Val Asp Leu Gly  Asp Ile Ser Gly Ile  Gln Ala Ser 
    1160                 1165                 1170             


Val Val  Asn Ile Gln Lys Glu  Ile Asp Arg Leu Asn  Glu Val Ala 
    1175                 1180                 1185             


Lys Asn  Leu Gln Glu Ser Leu  Ile Asp Leu Gln Glu  Leu Gly Lys 
    1190                 1195                 1200             


Tyr Glu  Gln Tyr Ile Lys Trp  Pro Trp Tyr Ile Trp  Leu Gly Phe 
    1205                 1210                 1215             


Ile Ala  Gly Leu Ile Ala Ile  Val Met Val Thr Ile  Met Leu Cys 
    1220                 1225                 1230             


Cys Met  Thr Ser Cys Cys Ser  Cys Leu Lys Gly Cys  Cys Ser Cys 
    1235                 1240                 1245             


Gly Ser  Cys Cys Lys Phe Asp  Glu Asp Asp Ser Glu  Pro Val Leu 
    1250                 1255                 1260             


Lys Gly  Val Lys Leu His Tyr  Thr 
    1265                 1270     


<210>  29
<211>  3822
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  S-(deg-S2) for Wuhan S-2P

<400>  29
atgttcgtct tcctggtcct gctgcctctg gtctcctcac agtgcgtcaa tctgacaact       60

cggactcagc tgccacctgc ttatactaat agcttcacca gaggcgtgta ctatcctgac      120

aaggtgttta gaagctccgt gctgcactct acacaggatc tgtttctgcc attctttagc      180

aacgtgacct ggttccacgc catccacgtg agcggcacca atggcacaaa gcggttcgac      240

aatcccgtgc tgccttttaa cgatggcgtg tacttcgcct ctaccgagaa gagcaacatc      300

atcagaggct ggatctttgg caccacactg gactccaaga cacagtctct gctgatcgtg      360

aacaatgcca ccaacgtggt catcaaggtg tgcgagttcc agttttgtaa tgatcccttc      420

ctgggcgtgt actatcacaa gaacaataag agctggatgg agtccgagtt tagagtgtat      480

tctagcgcca acaactgcac atttgagtac gtgagccagc ctttcctgat ggacctggag      540

ggcaagcagg gcaatttcaa gaacctgagg gagttcgtgt ttaagaatat cgacggctac      600

ttcaaaatct actctaagca cacccccatc aacctggtgc gcgacctgcc tcagggcttc      660

agcgccctgg agcccctggt ggatctgcct atcggcatca acatcacccg gtttcagaca      720

ctgctggccc tgcacagaag ctacctgaca cccggcgact cctctagcgg atggaccgcc      780

ggcgctgccg cctactatgt gggctacctc cagccccgga ccttcctgct gaagtacaac      840

gagaatggca ccatcacaga cgcagtggat tgcgccctgg accccctgag cgagacaaag      900

tgtacactga agtcctttac cgtggagaag ggcatctatc agacatccaa tttcagggtg      960

cagccaaccg agtctatcgt gcgctttcct aatatcacaa acctgtgccc atttggcgag     1020

gtgttcaacg caacccgctt cgccagcgtg tacgcctgga ataggaagcg gatcagcaac     1080

tgcgtggccg actatagcgt gctgtacaac tccgcctctt tcagcacctt taagtgctat     1140

ggcgtgtccc ccacaaagct gaatgacctg tgctttacca acgtctacgc cgattctttc     1200

gtgatcaggg gcgacgaggt gcgccagatc gcccccggcc agacaggcaa gatcgcagac     1260

tacaattata agctgccaga cgatttcacc ggctgcgtga tcgcctggaa cagcaacaat     1320

ctggattcca aagtgggcgg caactacaat tatctgtacc ggctgtttag aaagagcaat     1380

ctgaagccct tcgagaggga catctctaca gaaatctacc aggccggcag caccccttgc     1440

aatggcgtgg agggctttaa ctgttatttc ccactccagt cctacggctt ccagcccaca     1500

aacggcgtgg gctatcagcc ttaccgcgtg gtggtgctga gctttgagct gctgcacgcc     1560

ccagcaacag tgtgcggccc caagaagtcc accaatctgg tgaagaacaa gtgcgtgaac     1620

ttcaacttca acggcctgac cggcacaggc gtgctgaccg agtccaacaa gaagttcctg     1680

ccatttcagc agttcggcag ggacatcgca gataccacag acgccgtgcg cgacccacag     1740

accctggaga tcctggacat cacaccctgc tctttcggcg gcgtgagcgt gatcacaccc     1800

ggcaccaata caagcaacca ggtggccgtg ctgtatcagg acgtgaattg taccgaggtg     1860

cccgtggcta tccacgccga tcagctgacc ccaacatggc gggtgtacag caccggctcc     1920

aacgtcttcc agacaagagc cggatgcctg atcggagcag agcacgtgaa caattcctat     1980

gagtgcgaca tcccaatcgg cgccggcatc tgtgcctctt accagaccca gacaaactct     2040

cccagaagag cccggagcgt ggcctcccag tctatcatcg cctataccat gtccctgggc     2100

gccgagaaca gcgtggccta ctctcagaat agcatcgcca tcccaaccca gttcacaatc     2160

tctgtgacca cagagatcct gcccgtgtcc atgaccaaga catctgtgga ctgcacaatg     2220

tatatctgtg gcgattctac cgagtgcagc aacctgctgc tccagtacgg cagcttttgt     2280

acccagctga atagagccct gacaggcatc gccgtggagc aggataagaa cacacaggag     2340

gtgttcgccc aggtgaagca aatctacaag acccccccta tcaaggactt tggcggcttc     2400

caattttccc agatcctgcc tgatccatcc aagccttcta agcggagctt tatcgaggac     2460

ctgctgttca acaaggtgac cctggccgat gccggcttca tcaagcagta tggcgattgc     2520

ctgggcgaca tcgcagccag ggacctgatc tgcgcccaga agtttaatgg cctgaccgtg     2580

ctgccacccc tgctgacaga tgagatgatc gcacagtaca caagcgccct gctggccggc     2640

accatcacat ccggatggac cttcggcgca ggagccgccc tccagatccc ctttgccatg     2700

cagatggcct ataggttcaa cggcatcggc gtgacccaga atgtgctgta cgagaaccag     2760

aagctgatcg ccaatcagtt taactccgcc atcggcaaga tccaggacag cctgtcctct     2820

acagccagcg ccctgggcaa gctccaggat gtggtgaatc agaacgccca ggccctgaat     2880

accctggtga agcagctgag cagcaacttc ggcgccatct ctagcgtgct gaatgacatc     2940

ctgagccggc tggacccgcc ggaggcagag gtgcagatcg accggctgat caccggccgg     3000

ctccagagcc tccagaccta tgtgacacag cagctgatca gggccgccga gatcagggcc     3060

agcgccaatc tggcagcaac caagatgtcc gagtgcgtgc tgggccagtc taagagagtg     3120

gacttttgtg gcaagggcta tcacctgatg tccttccctc agtctgcccc acacggcgtg     3180

gtgtttctgc acgtgaccta cgtgcccgcc caggagaagc agttcaccac agcccctgcc     3240

atctgccacg atggcaaggc ccactttcca agggagggcg tgttcgtgtc ccagggcacc     3300

cactggtttg tgacacagcg caatttctac gagccccaga tcatcaccac agacaacacc     3360

ttcgtgagcg gcaactgtga cgtggtcatc ggcatcgtgc agaataccgt gtatgatcca     3420

ctccagcccg agctggacag ctttaaggag gagctggata agtatttcaa gcaacacacc     3480

tcccctgacg tggatctggg cgacatcagc ggcatccaag cctccgtggt gaacatccag     3540

aaggagatcg accgcctgaa cgaggtggct aagaatctgc aggagagcct gatcgacctc     3600

caggagctgg gcaagtatga gcagtacatc aagtggccct ggtacatctg gctgggcttc     3660

atcgccggcc tgatcgccat cgtgatggtg accatcatgc tgtgctgtat gacatcctgc     3720

tgttcttgcc tgaagggctg ctgtagctgt ggctcctgct gtaagtttga cgaggatgac     3780

tctgaacctg tgctgaaggg cgtgaagctg cattacacct aa                        3822


<210>  30
<211>  1273
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  S-(deg-S2) for Wuhan S-2P

<400>  30

Met Phe Val Phe Leu Val Leu Leu Pro Leu Val Ser Ser Gln Cys Val 
1               5                   10                  15      


Asn Leu Thr Thr Arg Thr Gln Leu Pro Pro Ala Tyr Thr Asn Ser Phe 
            20                  25                  30          


Thr Arg Gly Val Tyr Tyr Pro Asp Lys Val Phe Arg Ser Ser Val Leu 
        35                  40                  45              


His Ser Thr Gln Asp Leu Phe Leu Pro Phe Phe Ser Asn Val Thr Trp 
    50                  55                  60                  


Phe His Ala Ile His Val Ser Gly Thr Asn Gly Thr Lys Arg Phe Asp 
65                  70                  75                  80  


Asn Pro Val Leu Pro Phe Asn Asp Gly Val Tyr Phe Ala Ser Thr Glu 
                85                  90                  95      


Lys Ser Asn Ile Ile Arg Gly Trp Ile Phe Gly Thr Thr Leu Asp Ser 
            100                 105                 110         


Lys Thr Gln Ser Leu Leu Ile Val Asn Asn Ala Thr Asn Val Val Ile 
        115                 120                 125             


Lys Val Cys Glu Phe Gln Phe Cys Asn Asp Pro Phe Leu Gly Val Tyr 
    130                 135                 140                 


Tyr His Lys Asn Asn Lys Ser Trp Met Glu Ser Glu Phe Arg Val Tyr 
145                 150                 155                 160 


Ser Ser Ala Asn Asn Cys Thr Phe Glu Tyr Val Ser Gln Pro Phe Leu 
                165                 170                 175     


Met Asp Leu Glu Gly Lys Gln Gly Asn Phe Lys Asn Leu Arg Glu Phe 
            180                 185                 190         


Val Phe Lys Asn Ile Asp Gly Tyr Phe Lys Ile Tyr Ser Lys His Thr 
        195                 200                 205             


Pro Ile Asn Leu Val Arg Asp Leu Pro Gln Gly Phe Ser Ala Leu Glu 
    210                 215                 220                 


Pro Leu Val Asp Leu Pro Ile Gly Ile Asn Ile Thr Arg Phe Gln Thr 
225                 230                 235                 240 


Leu Leu Ala Leu His Arg Ser Tyr Leu Thr Pro Gly Asp Ser Ser Ser 
                245                 250                 255     


Gly Trp Thr Ala Gly Ala Ala Ala Tyr Tyr Val Gly Tyr Leu Gln Pro 
            260                 265                 270         


Arg Thr Phe Leu Leu Lys Tyr Asn Glu Asn Gly Thr Ile Thr Asp Ala 
        275                 280                 285             


Val Asp Cys Ala Leu Asp Pro Leu Ser Glu Thr Lys Cys Thr Leu Lys 
    290                 295                 300                 


Ser Phe Thr Val Glu Lys Gly Ile Tyr Gln Thr Ser Asn Phe Arg Val 
305                 310                 315                 320 


Gln Pro Thr Glu Ser Ile Val Arg Phe Pro Asn Ile Thr Asn Leu Cys 
                325                 330                 335     


Pro Phe Gly Glu Val Phe Asn Ala Thr Arg Phe Ala Ser Val Tyr Ala 
            340                 345                 350         


Trp Asn Arg Lys Arg Ile Ser Asn Cys Val Ala Asp Tyr Ser Val Leu 
        355                 360                 365             


Tyr Asn Ser Ala Ser Phe Ser Thr Phe Lys Cys Tyr Gly Val Ser Pro 
    370                 375                 380                 


Thr Lys Leu Asn Asp Leu Cys Phe Thr Asn Val Tyr Ala Asp Ser Phe 
385                 390                 395                 400 


Val Ile Arg Gly Asp Glu Val Arg Gln Ile Ala Pro Gly Gln Thr Gly 
                405                 410                 415     


Lys Ile Ala Asp Tyr Asn Tyr Lys Leu Pro Asp Asp Phe Thr Gly Cys 
            420                 425                 430         


Val Ile Ala Trp Asn Ser Asn Asn Leu Asp Ser Lys Val Gly Gly Asn 
        435                 440                 445             


Tyr Asn Tyr Leu Tyr Arg Leu Phe Arg Lys Ser Asn Leu Lys Pro Phe 
    450                 455                 460                 


Glu Arg Asp Ile Ser Thr Glu Ile Tyr Gln Ala Gly Ser Thr Pro Cys 
465                 470                 475                 480 


Asn Gly Val Glu Gly Phe Asn Cys Tyr Phe Pro Leu Gln Ser Tyr Gly 
                485                 490                 495     


Phe Gln Pro Thr Asn Gly Val Gly Tyr Gln Pro Tyr Arg Val Val Val 
            500                 505                 510         


Leu Ser Phe Glu Leu Leu His Ala Pro Ala Thr Val Cys Gly Pro Lys 
        515                 520                 525             


Lys Ser Thr Asn Leu Val Lys Asn Lys Cys Val Asn Phe Asn Phe Asn 
    530                 535                 540                 


Gly Leu Thr Gly Thr Gly Val Leu Thr Glu Ser Asn Lys Lys Phe Leu 
545                 550                 555                 560 


Pro Phe Gln Gln Phe Gly Arg Asp Ile Ala Asp Thr Thr Asp Ala Val 
                565                 570                 575     


Arg Asp Pro Gln Thr Leu Glu Ile Leu Asp Ile Thr Pro Cys Ser Phe 
            580                 585                 590         


Gly Gly Val Ser Val Ile Thr Pro Gly Thr Asn Thr Ser Asn Gln Val 
        595                 600                 605             


Ala Val Leu Tyr Gln Asp Val Asn Cys Thr Glu Val Pro Val Ala Ile 
    610                 615                 620                 


His Ala Asp Gln Leu Thr Pro Thr Trp Arg Val Tyr Ser Thr Gly Ser 
625                 630                 635                 640 


Asn Val Phe Gln Thr Arg Ala Gly Cys Leu Ile Gly Ala Glu His Val 
                645                 650                 655     


Asn Asn Ser Tyr Glu Cys Asp Ile Pro Ile Gly Ala Gly Ile Cys Ala 
            660                 665                 670         


Ser Tyr Gln Thr Gln Thr Asn Ser Pro Arg Arg Ala Arg Ser Val Ala 
        675                 680                 685             


Ser Gln Ser Ile Ile Ala Tyr Thr Met Ser Leu Gly Ala Glu Asn Ser 
    690                 695                 700                 


Val Ala Tyr Ser Gln Asn Ser Ile Ala Ile Pro Thr Gln Phe Thr Ile 
705                 710                 715                 720 


Ser Val Thr Thr Glu Ile Leu Pro Val Ser Met Thr Lys Thr Ser Val 
                725                 730                 735     


Asp Cys Thr Met Tyr Ile Cys Gly Asp Ser Thr Glu Cys Ser Asn Leu 
            740                 745                 750         


Leu Leu Gln Tyr Gly Ser Phe Cys Thr Gln Leu Asn Arg Ala Leu Thr 
        755                 760                 765             


Gly Ile Ala Val Glu Gln Asp Lys Asn Thr Gln Glu Val Phe Ala Gln 
    770                 775                 780                 


Val Lys Gln Ile Tyr Lys Thr Pro Pro Ile Lys Asp Phe Gly Gly Phe 
785                 790                 795                 800 


Gln Phe Ser Gln Ile Leu Pro Asp Pro Ser Lys Pro Ser Lys Arg Ser 
                805                 810                 815     


Phe Ile Glu Asp Leu Leu Phe Asn Lys Val Thr Leu Ala Asp Ala Gly 
            820                 825                 830         


Phe Ile Lys Gln Tyr Gly Asp Cys Leu Gly Asp Ile Ala Ala Arg Asp 
        835                 840                 845             


Leu Ile Cys Ala Gln Lys Phe Asn Gly Leu Thr Val Leu Pro Pro Leu 
    850                 855                 860                 


Leu Thr Asp Glu Met Ile Ala Gln Tyr Thr Ser Ala Leu Leu Ala Gly 
865                 870                 875                 880 


Thr Ile Thr Ser Gly Trp Thr Phe Gly Ala Gly Ala Ala Leu Gln Ile 
                885                 890                 895     


Pro Phe Ala Met Gln Met Ala Tyr Arg Phe Asn Gly Ile Gly Val Thr 
            900                 905                 910         


Gln Asn Val Leu Tyr Glu Asn Gln Lys Leu Ile Ala Asn Gln Phe Asn 
        915                 920                 925             


Ser Ala Ile Gly Lys Ile Gln Asp Ser Leu Ser Ser Thr Ala Ser Ala 
    930                 935                 940                 


Leu Gly Lys Leu Gln Asp Val Val Asn Gln Asn Ala Gln Ala Leu Asn 
945                 950                 955                 960 


Thr Leu Val Lys Gln Leu Ser Ser Asn Phe Gly Ala Ile Ser Ser Val 
                965                 970                 975     


Leu Asn Asp Ile Leu Ser Arg Leu Asp Pro Pro Glu Ala Glu Val Gln 
            980                 985                 990         


Ile Asp Arg Leu Ile Thr Gly Arg  Leu Gln Ser Leu Gln  Thr Tyr Val 
        995                 1000                 1005             


Thr Gln  Gln Leu Ile Arg Ala  Ala Glu Ile Arg Ala  Ser Ala Asn 
    1010                 1015                 1020             


Leu Ala  Ala Thr Lys Met Ser  Glu Cys Val Leu Gly  Gln Ser Lys 
    1025                 1030                 1035             


Arg Val  Asp Phe Cys Gly Lys  Gly Tyr His Leu Met  Ser Phe Pro 
    1040                 1045                 1050             


Gln Ser  Ala Pro His Gly Val  Val Phe Leu His Val  Thr Tyr Val 
    1055                 1060                 1065             


Pro Ala  Gln Glu Lys Gln Phe  Thr Thr Ala Pro Ala  Ile Cys His 
    1070                 1075                 1080             


Asp Gly  Lys Ala His Phe Pro  Arg Glu Gly Val Phe  Val Ser Gln 
    1085                 1090                 1095             


Gly Thr  His Trp Phe Val Thr  Gln Arg Asn Phe Tyr  Glu Pro Gln 
    1100                 1105                 1110             


Ile Ile  Thr Thr Asp Asn Thr  Phe Val Ser Gly Asn  Cys Asp Val 
    1115                 1120                 1125             


Val Ile  Gly Ile Val Gln Asn  Thr Val Tyr Asp Pro  Leu Gln Pro 
    1130                 1135                 1140             


Glu Leu  Asp Ser Phe Lys Glu  Glu Leu Asp Lys Tyr  Phe Lys Gln 
    1145                 1150                 1155             


His Thr  Ser Pro Asp Val Asp  Leu Gly Asp Ile Ser  Gly Ile Gln 
    1160                 1165                 1170             


Ala Ser  Val Val Asn Ile Gln  Lys Glu Ile Asp Arg  Leu Asn Glu 
    1175                 1180                 1185             


Val Ala  Lys Asn Leu Gln Glu  Ser Leu Ile Asp Leu  Gln Glu Leu 
    1190                 1195                 1200             


Gly Lys  Tyr Glu Gln Tyr Ile  Lys Trp Pro Trp Tyr  Ile Trp Leu 
    1205                 1210                 1215             


Gly Phe  Ile Ala Gly Leu Ile  Ala Ile Val Met Val  Thr Ile Met 
    1220                 1225                 1230             


Leu Cys  Cys Met Thr Ser Cys  Cys Ser Cys Leu Lys  Gly Cys Cys 
    1235                 1240                 1245             


Ser Cys  Gly Ser Cys Cys Lys  Phe Asp Glu Asp Asp  Ser Glu Pro 
    1250                 1255                 1260             


Val Leu  Lys Gly Val Lys Leu  His Tyr Thr 
    1265                 1270             


<210>  31
<211>  3816
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  S-(deg-S2) for Delta S-2P strain

<400>  31
atgttcgtct tcctggtcct gctgcctctg gtctcctcac agtgcgtcaa tctgcgaact       60

cggactcagc tgccacctgc ttatactaat agcttcacca gaggcgtgta ctatcctgac      120

aaggtgttta gaagctccgt gctgcactct acacaggatc tgtttctgcc attctttagc      180

aacgtgacct ggttccacgc catccacgtg agcggcacca atggcacaaa gcggttcgac      240

aatcccgtgc tgccttttaa cgatggcgtg tacttcgcct ctatcgagaa gagcaacatc      300

atcagaggct ggatctttgg caccacactg gactccaaga cacagtctct gctgatcgtg      360

aacaatgcca ccaacgtggt catcaaggtg tgcgagttcc agttttgtaa tgatcccttc      420

ctggacgtgt actatcacaa gaacaataag agctggatgg agtccggagt gtattctagc      480

gccaacaact gcacatttga gtacgtgagc cagcctttcc tgatggacct ggagggcaag      540

cagggcaatt tcaagaacct gagggagttc gtgtttaaga atatcgacgg ctacttcaaa      600

atctactcta agcacacccc catcaacctg gtgcgcgacc tgcctcaggg cttcagcgcc      660

ctggagcccc tggtggatct gcctatcggc atcaacatca cccggtttca gacactgctg      720

gccctgcaca gaagctacct gacacccggc gactcctcta gcggatggac cgccggcgct      780

gccgcctact atgtgggcta cctccagccc cggaccttcc tgctgaagta caacgagaat      840

ggcaccatca cagacgcagt ggattgcgcc ctggaccccc tgagcgagac aaagtgtaca      900

ctgaagtcct ttaccgtgga gaagggcatc tatcagacat ccaatttcag ggtgcagcca      960

accgagtcta tcgtgcgctt tcctaatatc acaaacctgt gcccatttgg cgaggtgttc     1020

aacgcaaccc gcttcgccag cgtgtacgcc tggaatagga agcggatcag caactgcgtg     1080

gccgactata gcgtgctgta caactccgcc tctttcagca cctttaagtg ctatggcgtg     1140

tcccccacaa agctgaatga cctgtgcttt accaacgtct acgccgattc tttcgtgatc     1200

aggggcgacg aggtgcgcca gatcgccccc ggccagacag gcaagatcgc agactacaat     1260

tataagctgc cagacgattt caccggctgc gtgatcgcct ggaacagcaa caatctggat     1320

tccaaagtgg gcggcaacta caattatcgg taccggctgt ttagaaagag caatctgaag     1380

cccttcgaga gggacatctc tacagaaatc taccaggccg gcagcaagcc ttgcaatggc     1440

gtggagggct ttaactgtta tttcccactc cagtcctacg gcttccagcc cacaaacggc     1500

gtgggctatc agccttaccg cgtggtggtg ctgagctttg agctgctgca cgccccagca     1560

acagtgtgcg gccccaagaa gtccaccaat ctggtgaaga acaagtgcgt gaacttcaac     1620

ttcaacggcc tgaccggcac aggcgtgctg accgagtcca acaagaagtt cctgccattt     1680

cagcagttcg gcagggacat cgcagatacc acagacgccg tgcgcgaccc acagaccctg     1740

gagatcctgg acatcacacc ctgctctttc ggcggcgtga gcgtgatcac acccggcacc     1800

aatacaagca accaggtggc cgtgctgtat cagggcgtga attgtaccga ggtgcccgtg     1860

gctatccacg ccgatcagct gaccccaaca tggcgggtgt acagcaccgg ctccaacgtc     1920

ttccagacaa gagccggatg cctgatcgga gcagagcacg tgaacaattc ctatgagtgc     1980

gacatcccaa tcggcgccgg catctgtgcc tcttaccaga cccagacaaa ctctcgcaga     2040

agagcccgga gcgtggcctc ccagtctatc atcgcctata ccatgtccct gggcgccgag     2100

aacagcgtgg cctactctca gaatagcatc gccatcccaa cccagttcac aatctctgtg     2160

accacagaga tcctgcccgt gtccatgacc aagacatctg tggactgcac aatgtatatc     2220

tgtggcgatt ctaccgagtg cagcaacctg ctgctccagt acggcagctt ttgtacccag     2280

ctgaatagag ccctgacagg catcgccgtg gagcaggata agaacacaca ggaggtgttc     2340

gcccaggtga agcaaatcta caagaccccc cctatcaagg actttggcgg cttccaattt     2400

tcccagatcc tgcctgatcc atccaagcct tctaagcgga gctttatcga ggacctgctg     2460

ttcaacaagg tgaccctggc cgatgccggc ttcatcaagc agtatggcga ttgcctgggc     2520

gacatcgcag ccagggacct gatctgcgcc cagaagttta atggcctgac cgtgctgcca     2580

cccctgctga cagatgagat gatcgcacag tacacaagcg ccctgctggc cggcaccatc     2640

acatccggat ggaccttcgg cgcaggagcc gccctccaga tcccctttgc catgcagatg     2700

gcctataggt tcaacggcat cggcgtgacc cagaatgtgc tgtacgagaa ccagaagctg     2760

atcgccaatc agtttaactc cgccatcggc aagatccagg acagcctgtc ctctacagcc     2820

agcgccctgg gcaagctcca gaatgtggtg aatcagaacg cccaggccct gaataccctg     2880

gtgaagcagc tgagcagcaa cttcggcgcc atctctagcg tgctgaatga catcctgagc     2940

cggctggacc gccgggaggc agaggtgcag atcgaccggc tgatcaccgg ccggctccag     3000

agcctccaga cctatgtgac acagcagctg atcagggccg ccgagatcag ggccagcgcc     3060

aatctggcag caaccaagat gtccgagtgc gtgctgggcc agtctaagag agtggacttt     3120

tgtggcaagg gctatcacct gatgtccttc cctcagtctg ccccacacgg cgtggtgttt     3180

ctgcacgtga cctacgtgcc cgcccaggag aagcagttca ccacagcccc tgccatctgc     3240

cacgatggca aggcccactt tccaagggag ggcgtgttcg tgtcccaggg cacccactgg     3300

tttgtgacac agcgcaattt ctacgagccc cagatcatca ccacagacaa caccttcgtg     3360

agcggcaact gtgacgtggt catcggcatc gtgcagaata ccgtgtatga tccactccag     3420

cccgagctgg acagctttaa ggaggagctg gataagtatt tcaagcaaca cacctcccct     3480

gacgtggatc tgggcgacat cagcggcatc caagcctccg tggtgaacat ccagaaggag     3540

atcgaccgcc tgaacgaggt ggctaagaat ctgcaggaga gcctgatcga cctccaggag     3600

ctgggcaagt atgagcagta catcaagtgg ccctggtaca tctggctggg cttcatcgcc     3660

ggcctgatcg ccatcgtgat ggtgaccatc atgctgtgct gtatgacatc ctgctgttct     3720

tgcctgaagg gctgctgtag ctgtggctcc tgctgtaagt ttgacgagga tgactctgaa     3780

cctgtgctga agggcgtgaa gctgcattac acctaa                               3816


<210>  32
<211>  1271
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  S-(deg-S2) for Delta S-2P strain

<400>  32

Met Phe Val Phe Leu Val Leu Leu Pro Leu Val Ser Ser Gln Cys Val 
1               5                   10                  15      


Asn Leu Arg Thr Arg Thr Gln Leu Pro Pro Ala Tyr Thr Asn Ser Phe 
            20                  25                  30          


Thr Arg Gly Val Tyr Tyr Pro Asp Lys Val Phe Arg Ser Ser Val Leu 
        35                  40                  45              


His Ser Thr Gln Asp Leu Phe Leu Pro Phe Phe Ser Asn Val Thr Trp 
    50                  55                  60                  


Phe His Ala Ile His Val Ser Gly Thr Asn Gly Thr Lys Arg Phe Asp 
65                  70                  75                  80  


Asn Pro Val Leu Pro Phe Asn Asp Gly Val Tyr Phe Ala Ser Ile Glu 
                85                  90                  95      


Lys Ser Asn Ile Ile Arg Gly Trp Ile Phe Gly Thr Thr Leu Asp Ser 
            100                 105                 110         


Lys Thr Gln Ser Leu Leu Ile Val Asn Asn Ala Thr Asn Val Val Ile 
        115                 120                 125             


Lys Val Cys Glu Phe Gln Phe Cys Asn Asp Pro Phe Leu Asp Val Tyr 
    130                 135                 140                 


Tyr His Lys Asn Asn Lys Ser Trp Met Glu Ser Gly Val Tyr Ser Ser 
145                 150                 155                 160 


Ala Asn Asn Cys Thr Phe Glu Tyr Val Ser Gln Pro Phe Leu Met Asp 
                165                 170                 175     


Leu Glu Gly Lys Gln Gly Asn Phe Lys Asn Leu Arg Glu Phe Val Phe 
            180                 185                 190         


Lys Asn Ile Asp Gly Tyr Phe Lys Ile Tyr Ser Lys His Thr Pro Ile 
        195                 200                 205             


Asn Leu Val Arg Asp Leu Pro Gln Gly Phe Ser Ala Leu Glu Pro Leu 
    210                 215                 220                 


Val Asp Leu Pro Ile Gly Ile Asn Ile Thr Arg Phe Gln Thr Leu Leu 
225                 230                 235                 240 


Ala Leu His Arg Ser Tyr Leu Thr Pro Gly Asp Ser Ser Ser Gly Trp 
                245                 250                 255     


Thr Ala Gly Ala Ala Ala Tyr Tyr Val Gly Tyr Leu Gln Pro Arg Thr 
            260                 265                 270         


Phe Leu Leu Lys Tyr Asn Glu Asn Gly Thr Ile Thr Asp Ala Val Asp 
        275                 280                 285             


Cys Ala Leu Asp Pro Leu Ser Glu Thr Lys Cys Thr Leu Lys Ser Phe 
    290                 295                 300                 


Thr Val Glu Lys Gly Ile Tyr Gln Thr Ser Asn Phe Arg Val Gln Pro 
305                 310                 315                 320 


Thr Glu Ser Ile Val Arg Phe Pro Asn Ile Thr Asn Leu Cys Pro Phe 
                325                 330                 335     


Gly Glu Val Phe Asn Ala Thr Arg Phe Ala Ser Val Tyr Ala Trp Asn 
            340                 345                 350         


Arg Lys Arg Ile Ser Asn Cys Val Ala Asp Tyr Ser Val Leu Tyr Asn 
        355                 360                 365             


Ser Ala Ser Phe Ser Thr Phe Lys Cys Tyr Gly Val Ser Pro Thr Lys 
    370                 375                 380                 


Leu Asn Asp Leu Cys Phe Thr Asn Val Tyr Ala Asp Ser Phe Val Ile 
385                 390                 395                 400 


Arg Gly Asp Glu Val Arg Gln Ile Ala Pro Gly Gln Thr Gly Lys Ile 
                405                 410                 415     


Ala Asp Tyr Asn Tyr Lys Leu Pro Asp Asp Phe Thr Gly Cys Val Ile 
            420                 425                 430         


Ala Trp Asn Ser Asn Asn Leu Asp Ser Lys Val Gly Gly Asn Tyr Asn 
        435                 440                 445             


Tyr Arg Tyr Arg Leu Phe Arg Lys Ser Asn Leu Lys Pro Phe Glu Arg 
    450                 455                 460                 


Asp Ile Ser Thr Glu Ile Tyr Gln Ala Gly Ser Lys Pro Cys Asn Gly 
465                 470                 475                 480 


Val Glu Gly Phe Asn Cys Tyr Phe Pro Leu Gln Ser Tyr Gly Phe Gln 
                485                 490                 495     


Pro Thr Asn Gly Val Gly Tyr Gln Pro Tyr Arg Val Val Val Leu Ser 
            500                 505                 510         


Phe Glu Leu Leu His Ala Pro Ala Thr Val Cys Gly Pro Lys Lys Ser 
        515                 520                 525             


Thr Asn Leu Val Lys Asn Lys Cys Val Asn Phe Asn Phe Asn Gly Leu 
    530                 535                 540                 


Thr Gly Thr Gly Val Leu Thr Glu Ser Asn Lys Lys Phe Leu Pro Phe 
545                 550                 555                 560 


Gln Gln Phe Gly Arg Asp Ile Ala Asp Thr Thr Asp Ala Val Arg Asp 
                565                 570                 575     


Pro Gln Thr Leu Glu Ile Leu Asp Ile Thr Pro Cys Ser Phe Gly Gly 
            580                 585                 590         


Val Ser Val Ile Thr Pro Gly Thr Asn Thr Ser Asn Gln Val Ala Val 
        595                 600                 605             


Leu Tyr Gln Gly Val Asn Cys Thr Glu Val Pro Val Ala Ile His Ala 
    610                 615                 620                 


Asp Gln Leu Thr Pro Thr Trp Arg Val Tyr Ser Thr Gly Ser Asn Val 
625                 630                 635                 640 


Phe Gln Thr Arg Ala Gly Cys Leu Ile Gly Ala Glu His Val Asn Asn 
                645                 650                 655     


Ser Tyr Glu Cys Asp Ile Pro Ile Gly Ala Gly Ile Cys Ala Ser Tyr 
            660                 665                 670         


Gln Thr Gln Thr Asn Ser Arg Arg Arg Ala Arg Ser Val Ala Ser Gln 
        675                 680                 685             


Ser Ile Ile Ala Tyr Thr Met Ser Leu Gly Ala Glu Asn Ser Val Ala 
    690                 695                 700                 


Tyr Ser Gln Asn Ser Ile Ala Ile Pro Thr Gln Phe Thr Ile Ser Val 
705                 710                 715                 720 


Thr Thr Glu Ile Leu Pro Val Ser Met Thr Lys Thr Ser Val Asp Cys 
                725                 730                 735     


Thr Met Tyr Ile Cys Gly Asp Ser Thr Glu Cys Ser Asn Leu Leu Leu 
            740                 745                 750         


Gln Tyr Gly Ser Phe Cys Thr Gln Leu Asn Arg Ala Leu Thr Gly Ile 
        755                 760                 765             


Ala Val Glu Gln Asp Lys Asn Thr Gln Glu Val Phe Ala Gln Val Lys 
    770                 775                 780                 


Gln Ile Tyr Lys Thr Pro Pro Ile Lys Asp Phe Gly Gly Phe Gln Phe 
785                 790                 795                 800 


Ser Gln Ile Leu Pro Asp Pro Ser Lys Pro Ser Lys Arg Ser Phe Ile 
                805                 810                 815     


Glu Asp Leu Leu Phe Asn Lys Val Thr Leu Ala Asp Ala Gly Phe Ile 
            820                 825                 830         


Lys Gln Tyr Gly Asp Cys Leu Gly Asp Ile Ala Ala Arg Asp Leu Ile 
        835                 840                 845             


Cys Ala Gln Lys Phe Asn Gly Leu Thr Val Leu Pro Pro Leu Leu Thr 
    850                 855                 860                 


Asp Glu Met Ile Ala Gln Tyr Thr Ser Ala Leu Leu Ala Gly Thr Ile 
865                 870                 875                 880 


Thr Ser Gly Trp Thr Phe Gly Ala Gly Ala Ala Leu Gln Ile Pro Phe 
                885                 890                 895     


Ala Met Gln Met Ala Tyr Arg Phe Asn Gly Ile Gly Val Thr Gln Asn 
            900                 905                 910         


Val Leu Tyr Glu Asn Gln Lys Leu Ile Ala Asn Gln Phe Asn Ser Ala 
        915                 920                 925             


Ile Gly Lys Ile Gln Asp Ser Leu Ser Ser Thr Ala Ser Ala Leu Gly 
    930                 935                 940                 


Lys Leu Gln Asn Val Val Asn Gln Asn Ala Gln Ala Leu Asn Thr Leu 
945                 950                 955                 960 


Val Lys Gln Leu Ser Ser Asn Phe Gly Ala Ile Ser Ser Val Leu Asn 
                965                 970                 975     


Asp Ile Leu Ser Arg Leu Asp Pro Pro Glu Ala Glu Val Gln Ile Asp 
            980                 985                 990         


Arg Leu Ile Thr Gly Arg Leu Gln  Ser Leu Gln Thr Tyr  Val Thr Gln 
        995                 1000                 1005             


Gln Leu  Ile Arg Ala Ala Glu  Ile Arg Ala Ser Ala  Asn Leu Ala 
    1010                 1015                 1020             


Ala Thr  Lys Met Ser Glu Cys  Val Leu Gly Gln Ser  Lys Arg Val 
    1025                 1030                 1035             


Asp Phe  Cys Gly Lys Gly Tyr  His Leu Met Ser Phe  Pro Gln Ser 
    1040                 1045                 1050             


Ala Pro  His Gly Val Val Phe  Leu His Val Thr Tyr  Val Pro Ala 
    1055                 1060                 1065             


Gln Glu  Lys Gln Phe Thr Thr  Ala Pro Ala Ile Cys  His Asp Gly 
    1070                 1075                 1080             


Lys Ala  His Phe Pro Arg Glu  Gly Val Phe Val Ser  Gln Gly Thr 
    1085                 1090                 1095             


His Trp  Phe Val Thr Gln Arg  Asn Phe Tyr Glu Pro  Gln Ile Ile 
    1100                 1105                 1110             


Thr Thr  Asp Asn Thr Phe Val  Ser Gly Asn Cys Asp  Val Val Ile 
    1115                 1120                 1125             


Gly Ile  Val Gln Asn Thr Val  Tyr Asp Pro Leu Gln  Pro Glu Leu 
    1130                 1135                 1140             


Asp Ser  Phe Lys Glu Glu Leu  Asp Lys Tyr Phe Lys  Gln His Thr 
    1145                 1150                 1155             


Ser Pro  Asp Val Asp Leu Gly  Asp Ile Ser Gly Ile  Gln Ala Ser 
    1160                 1165                 1170             


Val Val  Asn Ile Gln Lys Glu  Ile Asp Arg Leu Asn  Glu Val Ala 
    1175                 1180                 1185             


Lys Asn  Leu Gln Glu Ser Leu  Ile Asp Leu Gln Glu  Leu Gly Lys 
    1190                 1195                 1200             


Tyr Glu  Gln Tyr Ile Lys Trp  Pro Trp Tyr Ile Trp  Leu Gly Phe 
    1205                 1210                 1215             


Ile Ala  Gly Leu Ile Ala Ile  Val Met Val Thr Ile  Met Leu Cys 
    1220                 1225                 1230             


Cys Met  Thr Ser Cys Cys Ser  Cys Leu Lys Gly Cys  Cys Ser Cys 
    1235                 1240                 1245             


Gly Ser  Cys Cys Lys Phe Asp  Glu Asp Asp Ser Glu  Pro Val Leu 
    1250                 1255                 1260             


Lys Gly  Val Lys Leu His Tyr  Thr 
    1265                 1270     


<210>  33
<211>  3822
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  S-(S2-1194) for Wuhan S-2P strain

<400>  33
atgttcgtct tcctggtcct gctgcctctg gtctcctcac agtgcgtcaa tctgacaact       60

cggactcagc tgccacctgc ttatactaat agcttcacca gaggcgtgta ctatcctgac      120

aaggtgttta gaagctccgt gctgcactct acacaggatc tgtttctgcc attctttagc      180

aacgtgacct ggttccacgc catccacgtg agcggcacca atggcacaaa gcggttcgac      240

aatcccgtgc tgccttttaa cgatggcgtg tacttcgcct ctaccgagaa gagcaacatc      300

atcagaggct ggatctttgg caccacactg gactccaaga cacagtctct gctgatcgtg      360

aacaatgcca ccaacgtggt catcaaggtg tgcgagttcc agttttgtaa tgatcccttc      420

ctgggcgtgt actatcacaa gaacaataag agctggatgg agtccgagtt tagagtgtat      480

tctagcgcca acaactgcac atttgagtac gtgagccagc ctttcctgat ggacctggag      540

ggcaagcagg gcaatttcaa gaacctgagg gagttcgtgt ttaagaatat cgacggctac      600

ttcaaaatct actctaagca cacccccatc aacctggtgc gcgacctgcc tcagggcttc      660

agcgccctgg agcccctggt ggatctgcct atcggcatca acatcacccg gtttcagaca      720

ctgctggccc tgcacagaag ctacctgaca cccggcgact cctctagcgg atggaccgcc      780

ggcgctgccg cctactatgt gggctacctc cagccccgga ccttcctgct gaagtacaac      840

gagaatggca ccatcacaga cgcagtggat tgcgccctgg accccctgag cgagacaaag      900

tgtacactga agtcctttac cgtggagaag ggcatctatc agacatccaa tttcagggtg      960

cagccaaccg agtctatcgt gcgctttcct aatatcacaa acctgtgccc atttggcgag     1020

gtgttcaacg caacccgctt cgccagcgtg tacgcctgga ataggaagcg gatcagcaac     1080

tgcgtggccg actatagcgt gctgtacaac tccgcctctt tcagcacctt taagtgctat     1140

ggcgtgtccc ccacaaagct gaatgacctg tgctttacca acgtctacgc cgattctttc     1200

gtgatcaggg gcgacgaggt gcgccagatc gcccccggcc agacaggcaa gatcgcagac     1260

tacaattata agctgccaga cgatttcacc ggctgcgtga tcgcctggaa cagcaacaat     1320

ctggattcca aagtgggcgg caactacaat tatctgtacc ggctgtttag aaagagcaat     1380

ctgaagccct tcgagaggga catctctaca gaaatctacc aggccggcag caccccttgc     1440

aatggcgtgg agggctttaa ctgttatttc ccactccagt cctacggctt ccagcccaca     1500

aacggcgtgg gctatcagcc ttaccgcgtg gtggtgctga gctttgagct gctgcacgcc     1560

ccagcaacag tgtgcggccc caagaagtcc accaatctgg tgaagaacaa gtgcgtgaac     1620

ttcaacttca acggcctgac cggcacaggc gtgctgaccg agtccaacaa gaagttcctg     1680

ccatttcagc agttcggcag ggacatcgca gataccacag acgccgtgcg cgacccacag     1740

accctggaga tcctggacat cacaccctgc tctttcggcg gcgtgagcgt gatcacaccc     1800

ggcaccaata caagcaacca ggtggccgtg ctgtatcagg acgtgaattg taccgaggtg     1860

cccgtggcta tccacgccga tcagctgacc ccaacatggc gggtgtacag caccggctcc     1920

aacgtcttcc agacaagagc cggatgcctg atcggagcag agcacgtgaa caattcctat     1980

gagtgcgaca tcccaatcgg cgccggcatc tgtgcctctt accagaccca gacaaactct     2040

cccagaagag cccggagcgt ggcctcccag tctatcatcg cctataccat gtccctgggc     2100

gccgagaaca gcgtggccta ctctcagaat agcatcgcca tcccaaccca gttcacaatc     2160

tctgtgacca cagagatcct gcccgtgtcc atgaccaaga catctgtgga ctgcacaatg     2220

tatatctgtg gcgattctac cgagtgcagc aacctgctgc tccagtacgg cagcttttgt     2280

acccagctga atagagccct gacaggcatc gccgtggagc aggataagaa cacacaggag     2340

gtgttcgccc aggtgaagca aatctacaag acccccccta tcaaggactt tggcggcttc     2400

caattttccc agatcctgcc tgatccatcc aagccttcta agcggagctt tatcgaggac     2460

ctgctgttca acaaggtgac cctggccgat gccggcttca tcaagcagta tggcgattgc     2520

ctgggcgaca tcgcagccag ggacctgatc tgcgcccaga agtttaatgg cctgaccgtg     2580

ctgccacccc tgctgacaga tgagatgatc gcacagtaca caagcgccct gctggccggc     2640

accatcacat ccggatggac cttcggcgca ggagccgccc tccagatccc ctttgccatg     2700

cagatggcct ataggttcaa cggcatcggc gtgacccaga atgtgctgta cgagaaccag     2760

aagctgatcg ccaatcagtt taactccgcc atcggcaaga tccaggacag cctgtcctct     2820

acagccagcg ccctgggcaa gctccaggat gtggtgaatc agaacgccca ggccctgaat     2880

accctggtga agcagctgag cagcaacttc ggcgccatct ctagcgtgct gaatgacatc     2940

ctgagccggc tggacccgcc ggaggcagag gtgcagatcg accggctgat caccggccgg     3000

ctccagagcc tccagaccta tgtgacacag cagctgatca gggccgccga gatcagggcc     3060

agcgccaatc tggcagcaac caagatgtcc gagtgcgtgc tgggccagtc taagagagtg     3120

gacttttgtg gcaagggcta tcacctgatg tccttccctc agtctgcccc acacggcgtg     3180

gtgtttctgc acgtgaccta cgtgcccgcc caggagaagc agttcaccac agcccctgcc     3240

atctgccacg atggcaaggc ccactttcca agggagggcg tgttcgtgtc ccagggcacc     3300

cactggtttg tgacacagcg caatttctac gagccccaga tcatcaccac agacaacacc     3360

ttcgtgagcg gcaactgtga cgtggtcatc ggcatcgtgc agaataccgt gtatgatcca     3420

ctccagcccg agctggacag ctttaaggag gagctggata agtatttcaa gcaacacacc     3480

tcccctgacg tggatctggg cgacatcagc ggcatccaag cctccgtggt gaacatccag     3540

aaggagatcg accgcctgaa cgaggtggct aagaatctga acgagagcct gatcgacctc     3600

caggagctgg gcaagtatga gcagtacatc aagtggccct ggtacatctg gctgggcttc     3660

atcgccggcc tgatcgccat cgtgatggtg accatcatgc tgtgctgtat gacatcctgc     3720

tgttcttgcc tgaagggctg ctgtagctgt ggctcctgct gtaagtttga cgaggatgac     3780

tctgaacctg tgctgaaggg cgtgaagctg cattacacct aa                        3822


<210>  34
<211>  1273
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  S-(S2-1194) for Wuhan S-2P strain

<400>  34

Met Phe Val Phe Leu Val Leu Leu Pro Leu Val Ser Ser Gln Cys Val 
1               5                   10                  15      


Asn Leu Thr Thr Arg Thr Gln Leu Pro Pro Ala Tyr Thr Asn Ser Phe 
            20                  25                  30          


Thr Arg Gly Val Tyr Tyr Pro Asp Lys Val Phe Arg Ser Ser Val Leu 
        35                  40                  45              


His Ser Thr Gln Asp Leu Phe Leu Pro Phe Phe Ser Asn Val Thr Trp 
    50                  55                  60                  


Phe His Ala Ile His Val Ser Gly Thr Asn Gly Thr Lys Arg Phe Asp 
65                  70                  75                  80  


Asn Pro Val Leu Pro Phe Asn Asp Gly Val Tyr Phe Ala Ser Thr Glu 
                85                  90                  95      


Lys Ser Asn Ile Ile Arg Gly Trp Ile Phe Gly Thr Thr Leu Asp Ser 
            100                 105                 110         


Lys Thr Gln Ser Leu Leu Ile Val Asn Asn Ala Thr Asn Val Val Ile 
        115                 120                 125             


Lys Val Cys Glu Phe Gln Phe Cys Asn Asp Pro Phe Leu Gly Val Tyr 
    130                 135                 140                 


Tyr His Lys Asn Asn Lys Ser Trp Met Glu Ser Glu Phe Arg Val Tyr 
145                 150                 155                 160 


Ser Ser Ala Asn Asn Cys Thr Phe Glu Tyr Val Ser Gln Pro Phe Leu 
                165                 170                 175     


Met Asp Leu Glu Gly Lys Gln Gly Asn Phe Lys Asn Leu Arg Glu Phe 
            180                 185                 190         


Val Phe Lys Asn Ile Asp Gly Tyr Phe Lys Ile Tyr Ser Lys His Thr 
        195                 200                 205             


Pro Ile Asn Leu Val Arg Asp Leu Pro Gln Gly Phe Ser Ala Leu Glu 
    210                 215                 220                 


Pro Leu Val Asp Leu Pro Ile Gly Ile Asn Ile Thr Arg Phe Gln Thr 
225                 230                 235                 240 


Leu Leu Ala Leu His Arg Ser Tyr Leu Thr Pro Gly Asp Ser Ser Ser 
                245                 250                 255     


Gly Trp Thr Ala Gly Ala Ala Ala Tyr Tyr Val Gly Tyr Leu Gln Pro 
            260                 265                 270         


Arg Thr Phe Leu Leu Lys Tyr Asn Glu Asn Gly Thr Ile Thr Asp Ala 
        275                 280                 285             


Val Asp Cys Ala Leu Asp Pro Leu Ser Glu Thr Lys Cys Thr Leu Lys 
    290                 295                 300                 


Ser Phe Thr Val Glu Lys Gly Ile Tyr Gln Thr Ser Asn Phe Arg Val 
305                 310                 315                 320 


Gln Pro Thr Glu Ser Ile Val Arg Phe Pro Asn Ile Thr Asn Leu Cys 
                325                 330                 335     


Pro Phe Gly Glu Val Phe Asn Ala Thr Arg Phe Ala Ser Val Tyr Ala 
            340                 345                 350         


Trp Asn Arg Lys Arg Ile Ser Asn Cys Val Ala Asp Tyr Ser Val Leu 
        355                 360                 365             


Tyr Asn Ser Ala Ser Phe Ser Thr Phe Lys Cys Tyr Gly Val Ser Pro 
    370                 375                 380                 


Thr Lys Leu Asn Asp Leu Cys Phe Thr Asn Val Tyr Ala Asp Ser Phe 
385                 390                 395                 400 


Val Ile Arg Gly Asp Glu Val Arg Gln Ile Ala Pro Gly Gln Thr Gly 
                405                 410                 415     


Lys Ile Ala Asp Tyr Asn Tyr Lys Leu Pro Asp Asp Phe Thr Gly Cys 
            420                 425                 430         


Val Ile Ala Trp Asn Ser Asn Asn Leu Asp Ser Lys Val Gly Gly Asn 
        435                 440                 445             


Tyr Asn Tyr Leu Tyr Arg Leu Phe Arg Lys Ser Asn Leu Lys Pro Phe 
    450                 455                 460                 


Glu Arg Asp Ile Ser Thr Glu Ile Tyr Gln Ala Gly Ser Thr Pro Cys 
465                 470                 475                 480 


Asn Gly Val Glu Gly Phe Asn Cys Tyr Phe Pro Leu Gln Ser Tyr Gly 
                485                 490                 495     


Phe Gln Pro Thr Asn Gly Val Gly Tyr Gln Pro Tyr Arg Val Val Val 
            500                 505                 510         


Leu Ser Phe Glu Leu Leu His Ala Pro Ala Thr Val Cys Gly Pro Lys 
        515                 520                 525             


Lys Ser Thr Asn Leu Val Lys Asn Lys Cys Val Asn Phe Asn Phe Asn 
    530                 535                 540                 


Gly Leu Thr Gly Thr Gly Val Leu Thr Glu Ser Asn Lys Lys Phe Leu 
545                 550                 555                 560 


Pro Phe Gln Gln Phe Gly Arg Asp Ile Ala Asp Thr Thr Asp Ala Val 
                565                 570                 575     


Arg Asp Pro Gln Thr Leu Glu Ile Leu Asp Ile Thr Pro Cys Ser Phe 
            580                 585                 590         


Gly Gly Val Ser Val Ile Thr Pro Gly Thr Asn Thr Ser Asn Gln Val 
        595                 600                 605             


Ala Val Leu Tyr Gln Asp Val Asn Cys Thr Glu Val Pro Val Ala Ile 
    610                 615                 620                 


His Ala Asp Gln Leu Thr Pro Thr Trp Arg Val Tyr Ser Thr Gly Ser 
625                 630                 635                 640 


Asn Val Phe Gln Thr Arg Ala Gly Cys Leu Ile Gly Ala Glu His Val 
                645                 650                 655     


Asn Asn Ser Tyr Glu Cys Asp Ile Pro Ile Gly Ala Gly Ile Cys Ala 
            660                 665                 670         


Ser Tyr Gln Thr Gln Thr Asn Ser Pro Arg Arg Ala Arg Ser Val Ala 
        675                 680                 685             


Ser Gln Ser Ile Ile Ala Tyr Thr Met Ser Leu Gly Ala Glu Asn Ser 
    690                 695                 700                 


Val Ala Tyr Ser Gln Asn Ser Ile Ala Ile Pro Thr Gln Phe Thr Ile 
705                 710                 715                 720 


Ser Val Thr Thr Glu Ile Leu Pro Val Ser Met Thr Lys Thr Ser Val 
                725                 730                 735     


Asp Cys Thr Met Tyr Ile Cys Gly Asp Ser Thr Glu Cys Ser Asn Leu 
            740                 745                 750         


Leu Leu Gln Tyr Gly Ser Phe Cys Thr Gln Leu Asn Arg Ala Leu Thr 
        755                 760                 765             


Gly Ile Ala Val Glu Gln Asp Lys Asn Thr Gln Glu Val Phe Ala Gln 
    770                 775                 780                 


Val Lys Gln Ile Tyr Lys Thr Pro Pro Ile Lys Asp Phe Gly Gly Phe 
785                 790                 795                 800 


Gln Phe Ser Gln Ile Leu Pro Asp Pro Ser Lys Pro Ser Lys Arg Ser 
                805                 810                 815     


Phe Ile Glu Asp Leu Leu Phe Asn Lys Val Thr Leu Ala Asp Ala Gly 
            820                 825                 830         


Phe Ile Lys Gln Tyr Gly Asp Cys Leu Gly Asp Ile Ala Ala Arg Asp 
        835                 840                 845             


Leu Ile Cys Ala Gln Lys Phe Asn Gly Leu Thr Val Leu Pro Pro Leu 
    850                 855                 860                 


Leu Thr Asp Glu Met Ile Ala Gln Tyr Thr Ser Ala Leu Leu Ala Gly 
865                 870                 875                 880 


Thr Ile Thr Ser Gly Trp Thr Phe Gly Ala Gly Ala Ala Leu Gln Ile 
                885                 890                 895     


Pro Phe Ala Met Gln Met Ala Tyr Arg Phe Asn Gly Ile Gly Val Thr 
            900                 905                 910         


Gln Asn Val Leu Tyr Glu Asn Gln Lys Leu Ile Ala Asn Gln Phe Asn 
        915                 920                 925             


Ser Ala Ile Gly Lys Ile Gln Asp Ser Leu Ser Ser Thr Ala Ser Ala 
    930                 935                 940                 


Leu Gly Lys Leu Gln Asp Val Val Asn Gln Asn Ala Gln Ala Leu Asn 
945                 950                 955                 960 


Thr Leu Val Lys Gln Leu Ser Ser Asn Phe Gly Ala Ile Ser Ser Val 
                965                 970                 975     


Leu Asn Asp Ile Leu Ser Arg Leu Asp Pro Pro Glu Ala Glu Val Gln 
            980                 985                 990         


Ile Asp Arg Leu Ile Thr Gly Arg  Leu Gln Ser Leu Gln  Thr Tyr Val 
        995                 1000                 1005             


Thr Gln  Gln Leu Ile Arg Ala  Ala Glu Ile Arg Ala  Ser Ala Asn 
    1010                 1015                 1020             


Leu Ala  Ala Thr Lys Met Ser  Glu Cys Val Leu Gly  Gln Ser Lys 
    1025                 1030                 1035             


Arg Val  Asp Phe Cys Gly Lys  Gly Tyr His Leu Met  Ser Phe Pro 
    1040                 1045                 1050             


Gln Ser  Ala Pro His Gly Val  Val Phe Leu His Val  Thr Tyr Val 
    1055                 1060                 1065             


Pro Ala  Gln Glu Lys Gln Phe  Thr Thr Ala Pro Ala  Ile Cys His 
    1070                 1075                 1080             


Asp Gly  Lys Ala His Phe Pro  Arg Glu Gly Val Phe  Val Ser Gln 
    1085                 1090                 1095             


Gly Thr  His Trp Phe Val Thr  Gln Arg Asn Phe Tyr  Glu Pro Gln 
    1100                 1105                 1110             


Ile Ile  Thr Thr Asp Asn Thr  Phe Val Ser Gly Asn  Cys Asp Val 
    1115                 1120                 1125             


Val Ile  Gly Ile Val Gln Asn  Thr Val Tyr Asp Pro  Leu Gln Pro 
    1130                 1135                 1140             


Glu Leu  Asp Ser Phe Lys Glu  Glu Leu Asp Lys Tyr  Phe Lys Gln 
    1145                 1150                 1155             


His Thr  Ser Pro Asp Val Asp  Leu Gly Asp Ile Ser  Gly Ile Gln 
    1160                 1165                 1170             


Ala Ser  Val Val Asn Ile Gln  Lys Glu Ile Asp Arg  Leu Asn Glu 
    1175                 1180                 1185             


Val Ala  Lys Asn Leu Asn Glu  Ser Leu Ile Asp Leu  Gln Glu Leu 
    1190                 1195                 1200             


Gly Lys  Tyr Glu Gln Tyr Ile  Lys Trp Pro Trp Tyr  Ile Trp Leu 
    1205                 1210                 1215             


Gly Phe  Ile Ala Gly Leu Ile  Ala Ile Val Met Val  Thr Ile Met 
    1220                 1225                 1230             


Leu Cys  Cys Met Thr Ser Cys  Cys Ser Cys Leu Lys  Gly Cys Cys 
    1235                 1240                 1245             


Ser Cys  Gly Ser Cys Cys Lys  Phe Asp Glu Asp Asp  Ser Glu Pro 
    1250                 1255                 1260             


Val Leu  Lys Gly Val Lys Leu  His Tyr Thr 
    1265                 1270             


<210>  35
<211>  3822
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  S-(deg-RBD-801) for Wuhan S-2P strain

<400>  35
atgttcgtct tcctggtcct gctgcctctg gtctcctcac agtgcgtcaa tctgacaact       60

cggactcagc tgccacctgc ttatactaat agcttcacca gaggcgtgta ctatcctgac      120

aaggtgttta gaagctccgt gctgcactct acacaggatc tgtttctgcc attctttagc      180

aacgtgacct ggttccacgc catccacgtg agcggcacca atggcacaaa gcggttcgac      240

aatcccgtgc tgccttttaa cgatggcgtg tacttcgcct ctaccgagaa gagcaacatc      300

atcagaggct ggatctttgg caccacactg gactccaaga cacagtctct gctgatcgtg      360

aacaatgcca ccaacgtggt catcaaggtg tgcgagttcc agttttgtaa tgatcccttc      420

ctgggcgtgt actatcacaa gaacaataag agctggatgg agtccgagtt tagagtgtat      480

tctagcgcca acaactgcac atttgagtac gtgagccagc ctttcctgat ggacctggag      540

ggcaagcagg gcaatttcaa gaacctgagg gagttcgtgt ttaagaatat cgacggctac      600

ttcaaaatct actctaagca cacccccatc aacctggtgc gcgacctgcc tcagggcttc      660

agcgccctgg agcccctggt ggatctgcct atcggcatca acatcacccg gtttcagaca      720

ctgctggccc tgcacagaag ctacctgaca cccggcgact cctctagcgg atggaccgcc      780

ggcgctgccg cctactatgt gggctacctc cagccccgga ccttcctgct gaagtacaac      840

gagaatggca ccatcacaga cgcagtggat tgcgccctgg accccctgag cgagacaaag      900

tgtacactga agtcctttac cgtggagaag ggcatctatc agacatccaa tttcagggtg      960

cagccagccg aggcgatcgt gcgctttcct gaaatcacaa acctgtgccc atttggcgag     1020

gtgttcgagg caacccgctt cgccagcgtg tacgcctgga ataggaagcg gatcagcaac     1080

tgcgtggccg actatagcgt gctgtacaac tccgcctctt tcagcacctt taagtgctat     1140

ggcgtgtccc ccacaaagct gaatgacctg tgctttacca acgtctacgc cgattctttc     1200

gtgatcaggg gcgacgaggt gcgccagatc gcccccggcc agacaggcaa gatcgcagac     1260

tacaattata agctgccaga cgatttcacc ggctgcgtga tcgcctggaa cagcaacaat     1320

ctggattcca aagtgggcgg caactacaat tatctgtacc ggctgtttag aaagagcaat     1380

ctgaagccct tcgagaggga catctctaca gaaatctacc aggccggcag caccccttgc     1440

aatggcgtgg agggctttaa ctgttatttc ccactccagt cctacggctt ccagcccaca     1500

aacggcgtgg gctatcagcc ttaccgcgtg gtggtgctga gctttgagct gctgcacgcc     1560

ccagcaacag tgtgcggccc caagaagtcc accaatctgg tgaagaacaa gtgcgtgaac     1620

ttcaacttca acggcctgac cggcacaggc gtgctgaccg agtccaacaa gaagttcctg     1680

ccatttcagc agttcggcag ggacatcgca gataccacag acgccgtgcg cgacccacag     1740

accctggaga tcctggacat cacaccctgc tctttcggcg gcgtgagcgt gatcacaccc     1800

ggcaccaata caagcaacca ggtggccgtg ctgtatcagg acgtgaattg taccgaggtg     1860

cccgtggcta tccacgccga tcagctgacc ccaacatggc gggtgtacag caccggctcc     1920

aacgtcttcc agacaagagc cggatgcctg atcggagcag agcacgtgaa caattcctat     1980

gagtgcgaca tcccaatcgg cgccggcatc tgtgcctctt accagaccca gacaaactct     2040

cccagaagag cccggagcgt ggcctcccag tctatcatcg cctataccat gtccctgggc     2100

gccgagaaca gcgtggccta ctctaacaat agcatcgcca tcccaaccaa cttcacaatc     2160

tctgtgacca cagagatcct gcccgtgtcc atgaccaaga catctgtgga ctgcacaatg     2220

tatatctgtg gcgattctac cgagtgcagc aacctgctgc tccagtacgg cagcttttgt     2280

acccagctga atagagccct gacaggcatc gccgtggagc aggataagaa cacacaggag     2340

gtgttcgccc aggtgaagca aatctacaag acccccccta tcaaggactt tggcggcttc     2400

caattttccc agatcctgcc tgatccatcc aagccttcta agcggagctt tatcgaggac     2460

ctgctgttca acaaggtgac cctggccgat gccggcttca tcaagcagta tggcgattgc     2520

ctgggcgaca tcgcagccag ggacctgatc tgcgcccaga agtttaatgg cctgaccgtg     2580

ctgccacccc tgctgacaga tgagatgatc gcacagtaca caagcgccct gctggccggc     2640

accatcacat ccggatggac cttcggcgca ggagccgccc tccagatccc ctttgccatg     2700

cagatggcct ataggttcaa cggcatcggc gtgacccaga atgtgctgta cgagaaccag     2760

aagctgatcg ccaatcagtt taactccgcc atcggcaaga tccaggacag cctgtcctct     2820

acagccagcg ccctgggcaa gctccaggat gtggtgaatc agaacgccca ggccctgaat     2880

accctggtga agcagctgag cagcaacttc ggcgccatct ctagcgtgct gaatgacatc     2940

ctgagccggc tggacccgcc ggaggcagag gtgcagatcg accggctgat caccggccgg     3000

ctccagagcc tccagaccta tgtgacacag cagctgatca gggccgccga gatcagggcc     3060

agcgccaatc tggcagcaac caagatgtcc gagtgcgtgc tgggccagtc taagagagtg     3120

gacttttgtg gcaagggcta tcacctgatg tccttccctc agtctgcccc acacggcgtg     3180

gtgtttctgc acgtgaccta cgtgcccgcc caggagaaga acttcaccac agcccctgcc     3240

atctgccacg atggcaaggc ccactttcca agggagggcg tgttcgtgtc caacggcacc     3300

cactggtttg tgacacagcg caatttctac gagccccaga tcatcaccac agacaacacc     3360

ttcgtgagcg gcaactgtga cgtggtcatc ggcatcgtga acaataccgt gtatgatcca     3420

ctccagcccg agctggacag ctttaaggag gagctggata agtatttcaa gaatcacacc     3480

tcccctgacg tggatctggg cgacatcagc ggcatcaatg cctccgtggt gaacatccag     3540

aaggagatcg accgcctgaa cgaggtggct aagaatctga acgagagcct gatcgacctc     3600

caggagctgg gcaagtatga gcagtacatc aagtggccct ggtacatctg gctgggcttc     3660

atcgccggcc tgatcgccat cgtgatggtg accatcatgc tgtgctgtat gacatcctgc     3720

tgttcttgcc tgaagggctg ctgtagctgt ggctcctgct gtaagtttga cgaggatgac     3780

tctgaacctg tgctgaaggg cgtgaagctg cattacacct aa                        3822


<210>  36
<211>  1273
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  S-(deg-RBD-801) for Wuhan S-2P strain

<400>  36

Met Phe Val Phe Leu Val Leu Leu Pro Leu Val Ser Ser Gln Cys Val 
1               5                   10                  15      


Asn Leu Thr Thr Arg Thr Gln Leu Pro Pro Ala Tyr Thr Asn Ser Phe 
            20                  25                  30          


Thr Arg Gly Val Tyr Tyr Pro Asp Lys Val Phe Arg Ser Ser Val Leu 
        35                  40                  45              


His Ser Thr Gln Asp Leu Phe Leu Pro Phe Phe Ser Asn Val Thr Trp 
    50                  55                  60                  


Phe His Ala Ile His Val Ser Gly Thr Asn Gly Thr Lys Arg Phe Asp 
65                  70                  75                  80  


Asn Pro Val Leu Pro Phe Asn Asp Gly Val Tyr Phe Ala Ser Thr Glu 
                85                  90                  95      


Lys Ser Asn Ile Ile Arg Gly Trp Ile Phe Gly Thr Thr Leu Asp Ser 
            100                 105                 110         


Lys Thr Gln Ser Leu Leu Ile Val Asn Asn Ala Thr Asn Val Val Ile 
        115                 120                 125             


Lys Val Cys Glu Phe Gln Phe Cys Asn Asp Pro Phe Leu Gly Val Tyr 
    130                 135                 140                 


Tyr His Lys Asn Asn Lys Ser Trp Met Glu Ser Glu Phe Arg Val Tyr 
145                 150                 155                 160 


Ser Ser Ala Asn Asn Cys Thr Phe Glu Tyr Val Ser Gln Pro Phe Leu 
                165                 170                 175     


Met Asp Leu Glu Gly Lys Gln Gly Asn Phe Lys Asn Leu Arg Glu Phe 
            180                 185                 190         


Val Phe Lys Asn Ile Asp Gly Tyr Phe Lys Ile Tyr Ser Lys His Thr 
        195                 200                 205             


Pro Ile Asn Leu Val Arg Asp Leu Pro Gln Gly Phe Ser Ala Leu Glu 
    210                 215                 220                 


Pro Leu Val Asp Leu Pro Ile Gly Ile Asn Ile Thr Arg Phe Gln Thr 
225                 230                 235                 240 


Leu Leu Ala Leu His Arg Ser Tyr Leu Thr Pro Gly Asp Ser Ser Ser 
                245                 250                 255     


Gly Trp Thr Ala Gly Ala Ala Ala Tyr Tyr Val Gly Tyr Leu Gln Pro 
            260                 265                 270         


Arg Thr Phe Leu Leu Lys Tyr Asn Glu Asn Gly Thr Ile Thr Asp Ala 
        275                 280                 285             


Val Asp Cys Ala Leu Asp Pro Leu Ser Glu Thr Lys Cys Thr Leu Lys 
    290                 295                 300                 


Ser Phe Thr Val Glu Lys Gly Ile Tyr Gln Thr Ser Asn Phe Arg Val 
305                 310                 315                 320 


Gln Pro Ala Glu Ala Ile Val Arg Phe Pro Gln Ile Thr Asn Leu Cys 
                325                 330                 335     


Pro Phe Gly Glu Val Phe Gln Ala Thr Arg Phe Ala Ser Val Tyr Ala 
            340                 345                 350         


Trp Asn Arg Lys Arg Ile Ser Asn Cys Val Ala Asp Tyr Ser Val Leu 
        355                 360                 365             


Tyr Asn Ser Ala Ser Phe Ser Thr Phe Lys Cys Tyr Gly Val Ser Pro 
    370                 375                 380                 


Thr Lys Leu Asn Asp Leu Cys Phe Thr Asn Val Tyr Ala Asp Ser Phe 
385                 390                 395                 400 


Val Ile Arg Gly Asp Glu Val Arg Gln Ile Ala Pro Gly Gln Thr Gly 
                405                 410                 415     


Lys Ile Ala Asp Tyr Asn Tyr Lys Leu Pro Asp Asp Phe Thr Gly Cys 
            420                 425                 430         


Val Ile Ala Trp Asn Ser Asn Asn Leu Asp Ser Lys Val Gly Gly Asn 
        435                 440                 445             


Tyr Asn Tyr Leu Tyr Arg Leu Phe Arg Lys Ser Asn Leu Lys Pro Phe 
    450                 455                 460                 


Glu Arg Asp Ile Ser Thr Glu Ile Tyr Gln Ala Gly Ser Thr Pro Cys 
465                 470                 475                 480 


Asn Gly Val Glu Gly Phe Asn Cys Tyr Phe Pro Leu Gln Ser Tyr Gly 
                485                 490                 495     


Phe Gln Pro Thr Asn Gly Val Gly Tyr Gln Pro Tyr Arg Val Val Val 
            500                 505                 510         


Leu Ser Phe Glu Leu Leu His Ala Pro Ala Thr Val Cys Gly Pro Lys 
        515                 520                 525             


Lys Ser Thr Asn Leu Val Lys Asn Lys Cys Val Asn Phe Asn Phe Asn 
    530                 535                 540                 


Gly Leu Thr Gly Thr Gly Val Leu Thr Glu Ser Asn Lys Lys Phe Leu 
545                 550                 555                 560 


Pro Phe Gln Gln Phe Gly Arg Asp Ile Ala Asp Thr Thr Asp Ala Val 
                565                 570                 575     


Arg Asp Pro Gln Thr Leu Glu Ile Leu Asp Ile Thr Pro Cys Ser Phe 
            580                 585                 590         


Gly Gly Val Ser Val Ile Thr Pro Gly Thr Asn Thr Ser Asn Gln Val 
        595                 600                 605             


Ala Val Leu Tyr Gln Asp Val Asn Cys Thr Glu Val Pro Val Ala Ile 
    610                 615                 620                 


His Ala Asp Gln Leu Thr Pro Thr Trp Arg Val Tyr Ser Thr Gly Ser 
625                 630                 635                 640 


Asn Val Phe Gln Thr Arg Ala Gly Cys Leu Ile Gly Ala Glu His Val 
                645                 650                 655     


Asn Asn Ser Tyr Glu Cys Asp Ile Pro Ile Gly Ala Gly Ile Cys Ala 
            660                 665                 670         


Ser Tyr Gln Thr Gln Thr Asn Ser Pro Arg Arg Ala Arg Ser Val Ala 
        675                 680                 685             


Ser Gln Ser Ile Ile Ala Tyr Thr Met Ser Leu Gly Ala Glu Asn Ser 
    690                 695                 700                 


Val Ala Tyr Ser Asn Asn Ser Ile Ala Ile Pro Thr Asn Phe Thr Ile 
705                 710                 715                 720 


Ser Val Thr Thr Glu Ile Leu Pro Val Ser Met Thr Lys Thr Ser Val 
                725                 730                 735     


Asp Cys Thr Met Tyr Ile Cys Gly Asp Ser Thr Glu Cys Ser Asn Leu 
            740                 745                 750         


Leu Leu Gln Tyr Gly Ser Phe Cys Thr Gln Leu Asn Arg Ala Leu Thr 
        755                 760                 765             


Gly Ile Ala Val Glu Gln Asp Lys Asn Thr Gln Glu Val Phe Ala Gln 
    770                 775                 780                 


Val Lys Gln Ile Tyr Lys Thr Pro Pro Ile Lys Asp Phe Gly Gly Phe 
785                 790                 795                 800 


Gln Phe Ser Gln Ile Leu Pro Asp Pro Ser Lys Pro Ser Lys Arg Ser 
                805                 810                 815     


Phe Ile Glu Asp Leu Leu Phe Asn Lys Val Thr Leu Ala Asp Ala Gly 
            820                 825                 830         


Phe Ile Lys Gln Tyr Gly Asp Cys Leu Gly Asp Ile Ala Ala Arg Asp 
        835                 840                 845             


Leu Ile Cys Ala Gln Lys Phe Asn Gly Leu Thr Val Leu Pro Pro Leu 
    850                 855                 860                 


Leu Thr Asp Glu Met Ile Ala Gln Tyr Thr Ser Ala Leu Leu Ala Gly 
865                 870                 875                 880 


Thr Ile Thr Ser Gly Trp Thr Phe Gly Ala Gly Ala Ala Leu Gln Ile 
                885                 890                 895     


Pro Phe Ala Met Gln Met Ala Tyr Arg Phe Asn Gly Ile Gly Val Thr 
            900                 905                 910         


Gln Asn Val Leu Tyr Glu Asn Gln Lys Leu Ile Ala Asn Gln Phe Asn 
        915                 920                 925             


Ser Ala Ile Gly Lys Ile Gln Asp Ser Leu Ser Ser Thr Ala Ser Ala 
    930                 935                 940                 


Leu Gly Lys Leu Gln Asp Val Val Asn Gln Asn Ala Gln Ala Leu Asn 
945                 950                 955                 960 


Thr Leu Val Lys Gln Leu Ser Ser Asn Phe Gly Ala Ile Ser Ser Val 
                965                 970                 975     


Leu Asn Asp Ile Leu Ser Arg Leu Asp Pro Pro Glu Ala Glu Val Gln 
            980                 985                 990         


Ile Asp Arg Leu Ile Thr Gly Arg  Leu Gln Ser Leu Gln  Thr Tyr Val 
        995                 1000                 1005             


Thr Gln  Gln Leu Ile Arg Ala  Ala Glu Ile Arg Ala  Ser Ala Asn 
    1010                 1015                 1020             


Leu Ala  Ala Thr Lys Met Ser  Glu Cys Val Leu Gly  Gln Ser Lys 
    1025                 1030                 1035             


Arg Val  Asp Phe Cys Gly Lys  Gly Tyr His Leu Met  Ser Phe Pro 
    1040                 1045                 1050             


Gln Ser  Ala Pro His Gly Val  Val Phe Leu His Val  Thr Tyr Val 
    1055                 1060                 1065             


Pro Ala  Gln Glu Lys Asn Phe  Thr Thr Ala Pro Ala  Ile Cys His 
    1070                 1075                 1080             


Asp Gly  Lys Ala His Phe Pro  Arg Glu Gly Val Phe  Val Ser Asn 
    1085                 1090                 1095             


Gly Thr  His Trp Phe Val Thr  Gln Arg Asn Phe Tyr  Glu Pro Gln 
    1100                 1105                 1110             


Ile Ile  Thr Thr Asp Asn Thr  Phe Val Ser Gly Asn  Cys Asp Val 
    1115                 1120                 1125             


Val Ile  Gly Ile Val Asn Asn  Thr Val Tyr Asp Pro  Leu Gln Pro 
    1130                 1135                 1140             


Glu Leu  Asp Ser Phe Lys Glu  Glu Leu Asp Lys Tyr  Phe Lys Asn 
    1145                 1150                 1155             


His Thr  Ser Pro Asp Val Asp  Leu Gly Asp Ile Ser  Gly Ile Asn 
    1160                 1165                 1170             


Ala Ser  Val Val Asn Ile Gln  Lys Glu Ile Asp Arg  Leu Asn Glu 
    1175                 1180                 1185             


Val Ala  Lys Asn Leu Asn Glu  Ser Leu Ile Asp Leu  Gln Glu Leu 
    1190                 1195                 1200             


Gly Lys  Tyr Glu Gln Tyr Ile  Lys Trp Pro Trp Tyr  Ile Trp Leu 
    1205                 1210                 1215             


Gly Phe  Ile Ala Gly Leu Ile  Ala Ile Val Met Val  Thr Ile Met 
    1220                 1225                 1230             


Leu Cys  Cys Met Thr Ser Cys  Cys Ser Cys Leu Lys  Gly Cys Cys 
    1235                 1240                 1245             


Ser Cys  Gly Ser Cys Cys Lys  Phe Asp Glu Asp Asp  Ser Glu Pro 
    1250                 1255                 1260             


Val Leu  Lys Gly Val Lys Leu  His Tyr Thr 
    1265                 1270             


<210>  37
<211>  3822
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  S-(deg-RBD-1194) for Wuhan S-2P strain

<400>  37
atgttcgtct tcctggtcct gctgcctctg gtctcctcac agtgcgtcaa tctgacaact       60

cggactcagc tgccacctgc ttatactaat agcttcacca gaggcgtgta ctatcctgac      120

aaggtgttta gaagctccgt gctgcactct acacaggatc tgtttctgcc attctttagc      180

aacgtgacct ggttccacgc catccacgtg agcggcacca atggcacaaa gcggttcgac      240

aatcccgtgc tgccttttaa cgatggcgtg tacttcgcct ctaccgagaa gagcaacatc      300

atcagaggct ggatctttgg caccacactg gactccaaga cacagtctct gctgatcgtg      360

aacaatgcca ccaacgtggt catcaaggtg tgcgagttcc agttttgtaa tgatcccttc      420

ctgggcgtgt actatcacaa gaacaataag agctggatgg agtccgagtt tagagtgtat      480

tctagcgcca acaactgcac atttgagtac gtgagccagc ctttcctgat ggacctggag      540

ggcaagcagg gcaatttcaa gaacctgagg gagttcgtgt ttaagaatat cgacggctac      600

ttcaaaatct actctaagca cacccccatc aacctggtgc gcgacctgcc tcagggcttc      660

agcgccctgg agcccctggt ggatctgcct atcggcatca acatcacccg gtttcagaca      720

ctgctggccc tgcacagaag ctacctgaca cccggcgact cctctagcgg atggaccgcc      780

ggcgctgccg cctactatgt gggctacctc cagccccgga ccttcctgct gaagtacaac      840

gagaatggca ccatcacaga cgcagtggat tgcgccctgg accccctgag cgagacaaag      900

tgtacactga agtcctttac cgtggagaag ggcatctatc agacatccaa tttcagggtg      960

cagccagccg aggcgatcgt gcgctttcct gaaatcacaa acctgtgccc atttggcgag     1020

gtgttcgagg caacccgctt cgccagcgtg tacgcctgga ataggaagcg gatcagcaac     1080

tgcgtggccg actatagcgt gctgtacaac tccgcctctt tcagcacctt taagtgctat     1140

ggcgtgtccc ccacaaagct gaatgacctg tgctttacca acgtctacgc cgattctttc     1200

gtgatcaggg gcgacgaggt gcgccagatc gcccccggcc agacaggcaa gatcgcagac     1260

tacaattata agctgccaga cgatttcacc ggctgcgtga tcgcctggaa cagcaacaat     1320

ctggattcca aagtgggcgg caactacaat tatctgtacc ggctgtttag aaagagcaat     1380

ctgaagccct tcgagaggga catctctaca gaaatctacc aggccggcag caccccttgc     1440

aatggcgtgg agggctttaa ctgttatttc ccactccagt cctacggctt ccagcccaca     1500

aacggcgtgg gctatcagcc ttaccgcgtg gtggtgctga gctttgagct gctgcacgcc     1560

ccagcaacag tgtgcggccc caagaagtcc accaatctgg tgaagaacaa gtgcgtgaac     1620

ttcaacttca acggcctgac cggcacaggc gtgctgaccg agtccaacaa gaagttcctg     1680

ccatttcagc agttcggcag ggacatcgca gataccacag acgccgtgcg cgacccacag     1740

accctggaga tcctggacat cacaccctgc tctttcggcg gcgtgagcgt gatcacaccc     1800

ggcaccaata caagcaacca ggtggccgtg ctgtatcagg acgtgaattg taccgaggtg     1860

cccgtggcta tccacgccga tcagctgacc ccaacatggc gggtgtacag caccggctcc     1920

aacgtcttcc agacaagagc cggatgcctg atcggagcag agcacgtgaa caattcctat     1980

gagtgcgaca tcccaatcgg cgccggcatc tgtgcctctt accagaccca gacaaactct     2040

cccagaagag cccggagcgt ggcctcccag tctatcatcg cctataccat gtccctgggc     2100

gccgagaaca gcgtggccta ctctaacaat agcatcgcca tcccaaccaa cttcacaatc     2160

tctgtgacca cagagatcct gcccgtgtcc atgaccaaga catctgtgga ctgcacaatg     2220

tatatctgtg gcgattctac cgagtgcagc aacctgctgc tccagtacgg cagcttttgt     2280

acccagctga atagagccct gacaggcatc gccgtggagc aggataagaa cacacaggag     2340

gtgttcgccc aggtgaagca aatctacaag acccccccta tcaaggactt tggcggcttc     2400

aatttttccc agatcctgcc tgatccatcc aagccttcta agcggagctt tatcgaggac     2460

ctgctgttca acaaggtgac cctggccgat gccggcttca tcaagcagta tggcgattgc     2520

ctgggcgaca tcgcagccag ggacctgatc tgcgcccaga agtttaatgg cctgaccgtg     2580

ctgccacccc tgctgacaga tgagatgatc gcacagtaca caagcgccct gctggccggc     2640

accatcacat ccggatggac cttcggcgca ggagccgccc tccagatccc ctttgccatg     2700

cagatggcct ataggttcaa cggcatcggc gtgacccaga atgtgctgta cgagaaccag     2760

aagctgatcg ccaatcagtt taactccgcc atcggcaaga tccaggacag cctgtcctct     2820

acagccagcg ccctgggcaa gctccaggat gtggtgaatc agaacgccca ggccctgaat     2880

accctggtga agcagctgag cagcaacttc ggcgccatct ctagcgtgct gaatgacatc     2940

ctgagccggc tggacccgcc ggaggcagag gtgcagatcg accggctgat caccggccgg     3000

ctccagagcc tccagaccta tgtgacacag cagctgatca gggccgccga gatcagggcc     3060

agcgccaatc tggcagcaac caagatgtcc gagtgcgtgc tgggccagtc taagagagtg     3120

gacttttgtg gcaagggcta tcacctgatg tccttccctc agtctgcccc acacggcgtg     3180

gtgtttctgc acgtgaccta cgtgcccgcc caggagaaga acttcaccac agcccctgcc     3240

atctgccacg atggcaaggc ccactttcca agggagggcg tgttcgtgtc caacggcacc     3300

cactggtttg tgacacagcg caatttctac gagccccaga tcatcaccac agacaacacc     3360

ttcgtgagcg gcaactgtga cgtggtcatc ggcatcgtga acaataccgt gtatgatcca     3420

ctccagcccg agctggacag ctttaaggag gagctggata agtatttcaa gaatcacacc     3480

tcccctgacg tggatctggg cgacatcagc ggcatcaatg cctccgtggt gaacatccag     3540

aaggagatcg accgcctgaa cgaggtggct aagaatctgc aggagagcct gatcgacctc     3600

caggagctgg gcaagtatga gcagtacatc aagtggccct ggtacatctg gctgggcttc     3660

atcgccggcc tgatcgccat cgtgatggtg accatcatgc tgtgctgtat gacatcctgc     3720

tgttcttgcc tgaagggctg ctgtagctgt ggctcctgct gtaagtttga cgaggatgac     3780

tctgaacctg tgctgaaggg cgtgaagctg cattacacct aa                        3822


<210>  38
<211>  1273
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  S-(deg-RBD-1194) for Wuhan S-2P strain

<400>  38

Met Phe Val Phe Leu Val Leu Leu Pro Leu Val Ser Ser Gln Cys Val 
1               5                   10                  15      


Asn Leu Thr Thr Arg Thr Gln Leu Pro Pro Ala Tyr Thr Asn Ser Phe 
            20                  25                  30          


Thr Arg Gly Val Tyr Tyr Pro Asp Lys Val Phe Arg Ser Ser Val Leu 
        35                  40                  45              


His Ser Thr Gln Asp Leu Phe Leu Pro Phe Phe Ser Asn Val Thr Trp 
    50                  55                  60                  


Phe His Ala Ile His Val Ser Gly Thr Asn Gly Thr Lys Arg Phe Asp 
65                  70                  75                  80  


Asn Pro Val Leu Pro Phe Asn Asp Gly Val Tyr Phe Ala Ser Thr Glu 
                85                  90                  95      


Lys Ser Asn Ile Ile Arg Gly Trp Ile Phe Gly Thr Thr Leu Asp Ser 
            100                 105                 110         


Lys Thr Gln Ser Leu Leu Ile Val Asn Asn Ala Thr Asn Val Val Ile 
        115                 120                 125             


Lys Val Cys Glu Phe Gln Phe Cys Asn Asp Pro Phe Leu Gly Val Tyr 
    130                 135                 140                 


Tyr His Lys Asn Asn Lys Ser Trp Met Glu Ser Glu Phe Arg Val Tyr 
145                 150                 155                 160 


Ser Ser Ala Asn Asn Cys Thr Phe Glu Tyr Val Ser Gln Pro Phe Leu 
                165                 170                 175     


Met Asp Leu Glu Gly Lys Gln Gly Asn Phe Lys Asn Leu Arg Glu Phe 
            180                 185                 190         


Val Phe Lys Asn Ile Asp Gly Tyr Phe Lys Ile Tyr Ser Lys His Thr 
        195                 200                 205             


Pro Ile Asn Leu Val Arg Asp Leu Pro Gln Gly Phe Ser Ala Leu Glu 
    210                 215                 220                 


Pro Leu Val Asp Leu Pro Ile Gly Ile Asn Ile Thr Arg Phe Gln Thr 
225                 230                 235                 240 


Leu Leu Ala Leu His Arg Ser Tyr Leu Thr Pro Gly Asp Ser Ser Ser 
                245                 250                 255     


Gly Trp Thr Ala Gly Ala Ala Ala Tyr Tyr Val Gly Tyr Leu Gln Pro 
            260                 265                 270         


Arg Thr Phe Leu Leu Lys Tyr Asn Glu Asn Gly Thr Ile Thr Asp Ala 
        275                 280                 285             


Val Asp Cys Ala Leu Asp Pro Leu Ser Glu Thr Lys Cys Thr Leu Lys 
    290                 295                 300                 


Ser Phe Thr Val Glu Lys Gly Ile Tyr Gln Thr Ser Asn Phe Arg Val 
305                 310                 315                 320 


Gln Pro Ala Glu Ala Ile Val Arg Phe Pro Gln Ile Thr Asn Leu Cys 
                325                 330                 335     


Pro Phe Gly Glu Val Phe Gln Ala Thr Arg Phe Ala Ser Val Tyr Ala 
            340                 345                 350         


Trp Asn Arg Lys Arg Ile Ser Asn Cys Val Ala Asp Tyr Ser Val Leu 
        355                 360                 365             


Tyr Asn Ser Ala Ser Phe Ser Thr Phe Lys Cys Tyr Gly Val Ser Pro 
    370                 375                 380                 


Thr Lys Leu Asn Asp Leu Cys Phe Thr Asn Val Tyr Ala Asp Ser Phe 
385                 390                 395                 400 


Val Ile Arg Gly Asp Glu Val Arg Gln Ile Ala Pro Gly Gln Thr Gly 
                405                 410                 415     


Lys Ile Ala Asp Tyr Asn Tyr Lys Leu Pro Asp Asp Phe Thr Gly Cys 
            420                 425                 430         


Val Ile Ala Trp Asn Ser Asn Asn Leu Asp Ser Lys Val Gly Gly Asn 
        435                 440                 445             


Tyr Asn Tyr Leu Tyr Arg Leu Phe Arg Lys Ser Asn Leu Lys Pro Phe 
    450                 455                 460                 


Glu Arg Asp Ile Ser Thr Glu Ile Tyr Gln Ala Gly Ser Thr Pro Cys 
465                 470                 475                 480 


Asn Gly Val Glu Gly Phe Asn Cys Tyr Phe Pro Leu Gln Ser Tyr Gly 
                485                 490                 495     


Phe Gln Pro Thr Asn Gly Val Gly Tyr Gln Pro Tyr Arg Val Val Val 
            500                 505                 510         


Leu Ser Phe Glu Leu Leu His Ala Pro Ala Thr Val Cys Gly Pro Lys 
        515                 520                 525             


Lys Ser Thr Asn Leu Val Lys Asn Lys Cys Val Asn Phe Asn Phe Asn 
    530                 535                 540                 


Gly Leu Thr Gly Thr Gly Val Leu Thr Glu Ser Asn Lys Lys Phe Leu 
545                 550                 555                 560 


Pro Phe Gln Gln Phe Gly Arg Asp Ile Ala Asp Thr Thr Asp Ala Val 
                565                 570                 575     


Arg Asp Pro Gln Thr Leu Glu Ile Leu Asp Ile Thr Pro Cys Ser Phe 
            580                 585                 590         


Gly Gly Val Ser Val Ile Thr Pro Gly Thr Asn Thr Ser Asn Gln Val 
        595                 600                 605             


Ala Val Leu Tyr Gln Asp Val Asn Cys Thr Glu Val Pro Val Ala Ile 
    610                 615                 620                 


His Ala Asp Gln Leu Thr Pro Thr Trp Arg Val Tyr Ser Thr Gly Ser 
625                 630                 635                 640 


Asn Val Phe Gln Thr Arg Ala Gly Cys Leu Ile Gly Ala Glu His Val 
                645                 650                 655     


Asn Asn Ser Tyr Glu Cys Asp Ile Pro Ile Gly Ala Gly Ile Cys Ala 
            660                 665                 670         


Ser Tyr Gln Thr Gln Thr Asn Ser Pro Arg Arg Ala Arg Ser Val Ala 
        675                 680                 685             


Ser Gln Ser Ile Ile Ala Tyr Thr Met Ser Leu Gly Ala Glu Asn Ser 
    690                 695                 700                 


Val Ala Tyr Ser Asn Asn Ser Ile Ala Ile Pro Thr Asn Phe Thr Ile 
705                 710                 715                 720 


Ser Val Thr Thr Glu Ile Leu Pro Val Ser Met Thr Lys Thr Ser Val 
                725                 730                 735     


Asp Cys Thr Met Tyr Ile Cys Gly Asp Ser Thr Glu Cys Ser Asn Leu 
            740                 745                 750         


Leu Leu Gln Tyr Gly Ser Phe Cys Thr Gln Leu Asn Arg Ala Leu Thr 
        755                 760                 765             


Gly Ile Ala Val Glu Gln Asp Lys Asn Thr Gln Glu Val Phe Ala Gln 
    770                 775                 780                 


Val Lys Gln Ile Tyr Lys Thr Pro Pro Ile Lys Asp Phe Gly Gly Phe 
785                 790                 795                 800 


Asn Phe Ser Gln Ile Leu Pro Asp Pro Ser Lys Pro Ser Lys Arg Ser 
                805                 810                 815     


Phe Ile Glu Asp Leu Leu Phe Asn Lys Val Thr Leu Ala Asp Ala Gly 
            820                 825                 830         


Phe Ile Lys Gln Tyr Gly Asp Cys Leu Gly Asp Ile Ala Ala Arg Asp 
        835                 840                 845             


Leu Ile Cys Ala Gln Lys Phe Asn Gly Leu Thr Val Leu Pro Pro Leu 
    850                 855                 860                 


Leu Thr Asp Glu Met Ile Ala Gln Tyr Thr Ser Ala Leu Leu Ala Gly 
865                 870                 875                 880 


Thr Ile Thr Ser Gly Trp Thr Phe Gly Ala Gly Ala Ala Leu Gln Ile 
                885                 890                 895     


Pro Phe Ala Met Gln Met Ala Tyr Arg Phe Asn Gly Ile Gly Val Thr 
            900                 905                 910         


Gln Asn Val Leu Tyr Glu Asn Gln Lys Leu Ile Ala Asn Gln Phe Asn 
        915                 920                 925             


Ser Ala Ile Gly Lys Ile Gln Asp Ser Leu Ser Ser Thr Ala Ser Ala 
    930                 935                 940                 


Leu Gly Lys Leu Gln Asp Val Val Asn Gln Asn Ala Gln Ala Leu Asn 
945                 950                 955                 960 


Thr Leu Val Lys Gln Leu Ser Ser Asn Phe Gly Ala Ile Ser Ser Val 
                965                 970                 975     


Leu Asn Asp Ile Leu Ser Arg Leu Asp Pro Pro Glu Ala Glu Val Gln 
            980                 985                 990         


Ile Asp Arg Leu Ile Thr Gly Arg  Leu Gln Ser Leu Gln  Thr Tyr Val 
        995                 1000                 1005             


Thr Gln  Gln Leu Ile Arg Ala  Ala Glu Ile Arg Ala  Ser Ala Asn 
    1010                 1015                 1020             


Leu Ala  Ala Thr Lys Met Ser  Glu Cys Val Leu Gly  Gln Ser Lys 
    1025                 1030                 1035             


Arg Val  Asp Phe Cys Gly Lys  Gly Tyr His Leu Met  Ser Phe Pro 
    1040                 1045                 1050             


Gln Ser  Ala Pro His Gly Val  Val Phe Leu His Val  Thr Tyr Val 
    1055                 1060                 1065             


Pro Ala  Gln Glu Lys Asn Phe  Thr Thr Ala Pro Ala  Ile Cys His 
    1070                 1075                 1080             


Asp Gly  Lys Ala His Phe Pro  Arg Glu Gly Val Phe  Val Ser Asn 
    1085                 1090                 1095             


Gly Thr  His Trp Phe Val Thr  Gln Arg Asn Phe Tyr  Glu Pro Gln 
    1100                 1105                 1110             


Ile Ile  Thr Thr Asp Asn Thr  Phe Val Ser Gly Asn  Cys Asp Val 
    1115                 1120                 1125             


Val Ile  Gly Ile Val Asn Asn  Thr Val Tyr Asp Pro  Leu Gln Pro 
    1130                 1135                 1140             


Glu Leu  Asp Ser Phe Lys Glu  Glu Leu Asp Lys Tyr  Phe Lys Asn 
    1145                 1150                 1155             


His Thr  Ser Pro Asp Val Asp  Leu Gly Asp Ile Ser  Gly Ile Asn 
    1160                 1165                 1170             


Ala Ser  Val Val Asn Ile Gln  Lys Glu Ile Asp Arg  Leu Asn Glu 
    1175                 1180                 1185             


Val Ala  Lys Asn Leu Gln Glu  Ser Leu Ile Asp Leu  Gln Glu Leu 
    1190                 1195                 1200             


Gly Lys  Tyr Glu Gln Tyr Ile  Lys Trp Pro Trp Tyr  Ile Trp Leu 
    1205                 1210                 1215             


Gly Phe  Ile Ala Gly Leu Ile  Ala Ile Val Met Val  Thr Ile Met 
    1220                 1225                 1230             


Leu Cys  Cys Met Thr Ser Cys  Cys Ser Cys Leu Lys  Gly Cys Cys 
    1235                 1240                 1245             


Ser Cys  Gly Ser Cys Cys Lys  Phe Asp Glu Asp Asp  Ser Glu Pro 
    1250                 1255                 1260             


Val Leu  Lys Gly Val Lys Leu  His Tyr Thr 
    1265                 1270             


<210>  39
<211>  3822
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  S-(deg-RBD-122-165-234) for Wuhan S-2P strain

<400>  39
atgttcgtct tcctggtcct gctgcctctg gtctcctcac agtgcgtcaa tctgacaact       60

cggactcagc tgccacctgc ttatactaat agcttcacca gaggcgtgta ctatcctgac      120

aaggtgttta gaagctccgt gctgcactct acacaggatc tgtttctgcc attctttagc      180

aacgtgacct ggttccacgc catccacgtg agcggcacca atggcacaaa gcggttcgac      240

aatcccgtgc tgccttttaa cgatggcgtg tacttcgcct ctaccgagaa gagcaacatc      300

atcagaggct ggatctttgg caccacactg gactccaaga cacagtctct gctgatcgtg      360

aaccaagcca ccaacgtggt catcaaggtg tgcgagttcc agttttgtaa tgatcccttc      420

ctgggcgtgt actatcacaa gaacaataag agctggatgg agtccgagtt tagagtgtat      480

tctagcgcca accagtgcac atttgagtac gtgagccagc ctttcctgat ggacctggag      540

ggcaagcagg gcaatttcaa gaacctgagg gagttcgtgt ttaagaatat cgacggctac      600

ttcaaaatct actctaagca cacccccatc aacctggtgc gcgacctgcc tcagggcttc      660

agcgccctgg agcccctggt ggatctgcct atcggcatcc agatcacccg gtttcagaca      720

ctgctggccc tgcacagaag ctacctgaca cccggcgact cctctagcgg atggaccgcc      780

ggcgctgccg cctactatgt gggctacctc cagccccgga ccttcctgct gaagtacaac      840

gagaatggca ccatcacaga cgcagtggat tgcgccctgg accccctgag cgagacaaag      900

tgtacactga agtcctttac cgtggagaag ggcatctatc agacatccaa tttcagggtg      960

cagccagccg aggcgatcgt gcgctttcct gaaatcacaa acctgtgccc atttggcgag     1020

gtgttcgagg caacccgctt cgccagcgtg tacgcctgga ataggaagcg gatcagcaac     1080

tgcgtggccg actatagcgt gctgtacaac tccgcctctt tcagcacctt taagtgctat     1140

ggcgtgtccc ccacaaagct gaatgacctg tgctttacca acgtctacgc cgattctttc     1200

gtgatcaggg gcgacgaggt gcgccagatc gcccccggcc agacaggcaa gatcgcagac     1260

tacaattata agctgccaga cgatttcacc ggctgcgtga tcgcctggaa cagcaacaat     1320

ctggattcca aagtgggcgg caactacaat tatctgtacc ggctgtttag aaagagcaat     1380

ctgaagccct tcgagaggga catctctaca gaaatctacc aggccggcag caccccttgc     1440

aatggcgtgg agggctttaa ctgttatttc ccactccagt cctacggctt ccagcccaca     1500

aacggcgtgg gctatcagcc ttaccgcgtg gtggtgctga gctttgagct gctgcacgcc     1560

ccagcaacag tgtgcggccc caagaagtcc accaatctgg tgaagaacaa gtgcgtgaac     1620

ttcaacttca acggcctgac cggcacaggc gtgctgaccg agtccaacaa gaagttcctg     1680

ccatttcagc agttcggcag ggacatcgca gataccacag acgccgtgcg cgacccacag     1740

accctggaga tcctggacat cacaccctgc tctttcggcg gcgtgagcgt gatcacaccc     1800

ggcaccaata caagcaacca ggtggccgtg ctgtatcagg acgtgaattg taccgaggtg     1860

cccgtggcta tccacgccga tcagctgacc ccaacatggc gggtgtacag caccggctcc     1920

aacgtcttcc agacaagagc cggatgcctg atcggagcag agcacgtgaa caattcctat     1980

gagtgcgaca tcccaatcgg cgccggcatc tgtgcctctt accagaccca gacaaactct     2040

cccagaagag cccggagcgt ggcctcccag tctatcatcg cctataccat gtccctgggc     2100

gccgagaaca gcgtggccta ctctaacaat agcatcgcca tcccaaccaa cttcacaatc     2160

tctgtgacca cagagatcct gcccgtgtcc atgaccaaga catctgtgga ctgcacaatg     2220

tatatctgtg gcgattctac cgagtgcagc aacctgctgc tccagtacgg cagcttttgt     2280

acccagctga atagagccct gacaggcatc gccgtggagc aggataagaa cacacaggag     2340

gtgttcgccc aggtgaagca aatctacaag acccccccta tcaaggactt tggcggcttc     2400

aatttttccc agatcctgcc tgatccatcc aagccttcta agcggagctt tatcgaggac     2460

ctgctgttca acaaggtgac cctggccgat gccggcttca tcaagcagta tggcgattgc     2520

ctgggcgaca tcgcagccag ggacctgatc tgcgcccaga agtttaatgg cctgaccgtg     2580

ctgccacccc tgctgacaga tgagatgatc gcacagtaca caagcgccct gctggccggc     2640

accatcacat ccggatggac cttcggcgca ggagccgccc tccagatccc ctttgccatg     2700

cagatggcct ataggttcaa cggcatcggc gtgacccaga atgtgctgta cgagaaccag     2760

aagctgatcg ccaatcagtt taactccgcc atcggcaaga tccaggacag cctgtcctct     2820

acagccagcg ccctgggcaa gctccaggat gtggtgaatc agaacgccca ggccctgaat     2880

accctggtga agcagctgag cagcaacttc ggcgccatct ctagcgtgct gaatgacatc     2940

ctgagccggc tggacccgcc ggaggcagag gtgcagatcg accggctgat caccggccgg     3000

ctccagagcc tccagaccta tgtgacacag cagctgatca gggccgccga gatcagggcc     3060

agcgccaatc tggcagcaac caagatgtcc gagtgcgtgc tgggccagtc taagagagtg     3120

gacttttgtg gcaagggcta tcacctgatg tccttccctc agtctgcccc acacggcgtg     3180

gtgtttctgc acgtgaccta cgtgcccgcc caggagaaga acttcaccac agcccctgcc     3240

atctgccacg atggcaaggc ccactttcca agggagggcg tgttcgtgtc caacggcacc     3300

cactggtttg tgacacagcg caatttctac gagccccaga tcatcaccac agacaacacc     3360

ttcgtgagcg gcaactgtga cgtggtcatc ggcatcgtga acaataccgt gtatgatcca     3420

ctccagcccg agctggacag ctttaaggag gagctggata agtatttcaa gaatcacacc     3480

tcccctgacg tggatctggg cgacatcagc ggcatcaatg cctccgtggt gaacatccag     3540

aaggagatcg accgcctgaa cgaggtggct aagaatctga acgagagcct gatcgacctc     3600

caggagctgg gcaagtatga gcagtacatc aagtggccct ggtacatctg gctgggcttc     3660

atcgccggcc tgatcgccat cgtgatggtg accatcatgc tgtgctgtat gacatcctgc     3720

tgttcttgcc tgaagggctg ctgtagctgt ggctcctgct gtaagtttga cgaggatgac     3780

tctgaacctg tgctgaaggg cgtgaagctg cattacacct aa                        3822


<210>  40
<211>  1273
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  S-(deg-RBD-122-165-234) for Wuhan S-2P strain

<400>  40

Met Phe Val Phe Leu Val Leu Leu Pro Leu Val Ser Ser Gln Cys Val 
1               5                   10                  15      


Asn Leu Thr Thr Arg Thr Gln Leu Pro Pro Ala Tyr Thr Asn Ser Phe 
            20                  25                  30          


Thr Arg Gly Val Tyr Tyr Pro Asp Lys Val Phe Arg Ser Ser Val Leu 
        35                  40                  45              


His Ser Thr Gln Asp Leu Phe Leu Pro Phe Phe Ser Asn Val Thr Trp 
    50                  55                  60                  


Phe His Ala Ile His Val Ser Gly Thr Asn Gly Thr Lys Arg Phe Asp 
65                  70                  75                  80  


Asn Pro Val Leu Pro Phe Asn Asp Gly Val Tyr Phe Ala Ser Thr Glu 
                85                  90                  95      


Lys Ser Asn Ile Ile Arg Gly Trp Ile Phe Gly Thr Thr Leu Asp Ser 
            100                 105                 110         


Lys Thr Gln Ser Leu Leu Ile Val Asn Gln Ala Thr Asn Val Val Ile 
        115                 120                 125             


Lys Val Cys Glu Phe Gln Phe Cys Asn Asp Pro Phe Leu Gly Val Tyr 
    130                 135                 140                 


Tyr His Lys Asn Asn Lys Ser Trp Met Glu Ser Glu Phe Arg Val Tyr 
145                 150                 155                 160 


Ser Ser Ala Asn Gln Cys Thr Phe Glu Tyr Val Ser Gln Pro Phe Leu 
                165                 170                 175     


Met Asp Leu Glu Gly Lys Gln Gly Asn Phe Lys Asn Leu Arg Glu Phe 
            180                 185                 190         


Val Phe Lys Asn Ile Asp Gly Tyr Phe Lys Ile Tyr Ser Lys His Thr 
        195                 200                 205             


Pro Ile Asn Leu Val Arg Asp Leu Pro Gln Gly Phe Ser Ala Leu Glu 
    210                 215                 220                 


Pro Leu Val Asp Leu Pro Ile Gly Ile Gln Ile Thr Arg Phe Gln Thr 
225                 230                 235                 240 


Leu Leu Ala Leu His Arg Ser Tyr Leu Thr Pro Gly Asp Ser Ser Ser 
                245                 250                 255     


Gly Trp Thr Ala Gly Ala Ala Ala Tyr Tyr Val Gly Tyr Leu Gln Pro 
            260                 265                 270         


Arg Thr Phe Leu Leu Lys Tyr Asn Glu Asn Gly Thr Ile Thr Asp Ala 
        275                 280                 285             


Val Asp Cys Ala Leu Asp Pro Leu Ser Glu Thr Lys Cys Thr Leu Lys 
    290                 295                 300                 


Ser Phe Thr Val Glu Lys Gly Ile Tyr Gln Thr Ser Asn Phe Arg Val 
305                 310                 315                 320 


Gln Pro Ala Glu Ala Ile Val Arg Phe Pro Gln Ile Thr Asn Leu Cys 
                325                 330                 335     


Pro Phe Gly Glu Val Phe Gln Ala Thr Arg Phe Ala Ser Val Tyr Ala 
            340                 345                 350         


Trp Asn Arg Lys Arg Ile Ser Asn Cys Val Ala Asp Tyr Ser Val Leu 
        355                 360                 365             


Tyr Asn Ser Ala Ser Phe Ser Thr Phe Lys Cys Tyr Gly Val Ser Pro 
    370                 375                 380                 


Thr Lys Leu Asn Asp Leu Cys Phe Thr Asn Val Tyr Ala Asp Ser Phe 
385                 390                 395                 400 


Val Ile Arg Gly Asp Glu Val Arg Gln Ile Ala Pro Gly Gln Thr Gly 
                405                 410                 415     


Lys Ile Ala Asp Tyr Asn Tyr Lys Leu Pro Asp Asp Phe Thr Gly Cys 
            420                 425                 430         


Val Ile Ala Trp Asn Ser Asn Asn Leu Asp Ser Lys Val Gly Gly Asn 
        435                 440                 445             


Tyr Asn Tyr Leu Tyr Arg Leu Phe Arg Lys Ser Asn Leu Lys Pro Phe 
    450                 455                 460                 


Glu Arg Asp Ile Ser Thr Glu Ile Tyr Gln Ala Gly Ser Thr Pro Cys 
465                 470                 475                 480 


Asn Gly Val Glu Gly Phe Asn Cys Tyr Phe Pro Leu Gln Ser Tyr Gly 
                485                 490                 495     


Phe Gln Pro Thr Asn Gly Val Gly Tyr Gln Pro Tyr Arg Val Val Val 
            500                 505                 510         


Leu Ser Phe Glu Leu Leu His Ala Pro Ala Thr Val Cys Gly Pro Lys 
        515                 520                 525             


Lys Ser Thr Asn Leu Val Lys Asn Lys Cys Val Asn Phe Asn Phe Asn 
    530                 535                 540                 


Gly Leu Thr Gly Thr Gly Val Leu Thr Glu Ser Asn Lys Lys Phe Leu 
545                 550                 555                 560 


Pro Phe Gln Gln Phe Gly Arg Asp Ile Ala Asp Thr Thr Asp Ala Val 
                565                 570                 575     


Arg Asp Pro Gln Thr Leu Glu Ile Leu Asp Ile Thr Pro Cys Ser Phe 
            580                 585                 590         


Gly Gly Val Ser Val Ile Thr Pro Gly Thr Asn Thr Ser Asn Gln Val 
        595                 600                 605             


Ala Val Leu Tyr Gln Asp Val Asn Cys Thr Glu Val Pro Val Ala Ile 
    610                 615                 620                 


His Ala Asp Gln Leu Thr Pro Thr Trp Arg Val Tyr Ser Thr Gly Ser 
625                 630                 635                 640 


Asn Val Phe Gln Thr Arg Ala Gly Cys Leu Ile Gly Ala Glu His Val 
                645                 650                 655     


Asn Asn Ser Tyr Glu Cys Asp Ile Pro Ile Gly Ala Gly Ile Cys Ala 
            660                 665                 670         


Ser Tyr Gln Thr Gln Thr Asn Ser Pro Arg Arg Ala Arg Ser Val Ala 
        675                 680                 685             


Ser Gln Ser Ile Ile Ala Tyr Thr Met Ser Leu Gly Ala Glu Asn Ser 
    690                 695                 700                 


Val Ala Tyr Ser Asn Asn Ser Ile Ala Ile Pro Thr Asn Phe Thr Ile 
705                 710                 715                 720 


Ser Val Thr Thr Glu Ile Leu Pro Val Ser Met Thr Lys Thr Ser Val 
                725                 730                 735     


Asp Cys Thr Met Tyr Ile Cys Gly Asp Ser Thr Glu Cys Ser Asn Leu 
            740                 745                 750         


Leu Leu Gln Tyr Gly Ser Phe Cys Thr Gln Leu Asn Arg Ala Leu Thr 
        755                 760                 765             


Gly Ile Ala Val Glu Gln Asp Lys Asn Thr Gln Glu Val Phe Ala Gln 
    770                 775                 780                 


Val Lys Gln Ile Tyr Lys Thr Pro Pro Ile Lys Asp Phe Gly Gly Phe 
785                 790                 795                 800 


Asn Phe Ser Gln Ile Leu Pro Asp Pro Ser Lys Pro Ser Lys Arg Ser 
                805                 810                 815     


Phe Ile Glu Asp Leu Leu Phe Asn Lys Val Thr Leu Ala Asp Ala Gly 
            820                 825                 830         


Phe Ile Lys Gln Tyr Gly Asp Cys Leu Gly Asp Ile Ala Ala Arg Asp 
        835                 840                 845             


Leu Ile Cys Ala Gln Lys Phe Asn Gly Leu Thr Val Leu Pro Pro Leu 
    850                 855                 860                 


Leu Thr Asp Glu Met Ile Ala Gln Tyr Thr Ser Ala Leu Leu Ala Gly 
865                 870                 875                 880 


Thr Ile Thr Ser Gly Trp Thr Phe Gly Ala Gly Ala Ala Leu Gln Ile 
                885                 890                 895     


Pro Phe Ala Met Gln Met Ala Tyr Arg Phe Asn Gly Ile Gly Val Thr 
            900                 905                 910         


Gln Asn Val Leu Tyr Glu Asn Gln Lys Leu Ile Ala Asn Gln Phe Asn 
        915                 920                 925             


Ser Ala Ile Gly Lys Ile Gln Asp Ser Leu Ser Ser Thr Ala Ser Ala 
    930                 935                 940                 


Leu Gly Lys Leu Gln Asp Val Val Asn Gln Asn Ala Gln Ala Leu Asn 
945                 950                 955                 960 


Thr Leu Val Lys Gln Leu Ser Ser Asn Phe Gly Ala Ile Ser Ser Val 
                965                 970                 975     


Leu Asn Asp Ile Leu Ser Arg Leu Asp Pro Pro Glu Ala Glu Val Gln 
            980                 985                 990         


Ile Asp Arg Leu Ile Thr Gly Arg  Leu Gln Ser Leu Gln  Thr Tyr Val 
        995                 1000                 1005             


Thr Gln  Gln Leu Ile Arg Ala  Ala Glu Ile Arg Ala  Ser Ala Asn 
    1010                 1015                 1020             


Leu Ala  Ala Thr Lys Met Ser  Glu Cys Val Leu Gly  Gln Ser Lys 
    1025                 1030                 1035             


Arg Val  Asp Phe Cys Gly Lys  Gly Tyr His Leu Met  Ser Phe Pro 
    1040                 1045                 1050             


Gln Ser  Ala Pro His Gly Val  Val Phe Leu His Val  Thr Tyr Val 
    1055                 1060                 1065             


Pro Ala  Gln Glu Lys Asn Phe  Thr Thr Ala Pro Ala  Ile Cys His 
    1070                 1075                 1080             


Asp Gly  Lys Ala His Phe Pro  Arg Glu Gly Val Phe  Val Ser Asn 
    1085                 1090                 1095             


Gly Thr  His Trp Phe Val Thr  Gln Arg Asn Phe Tyr  Glu Pro Gln 
    1100                 1105                 1110             


Ile Ile  Thr Thr Asp Asn Thr  Phe Val Ser Gly Asn  Cys Asp Val 
    1115                 1120                 1125             


Val Ile  Gly Ile Val Asn Asn  Thr Val Tyr Asp Pro  Leu Gln Pro 
    1130                 1135                 1140             


Glu Leu  Asp Ser Phe Lys Glu  Glu Leu Asp Lys Tyr  Phe Lys Asn 
    1145                 1150                 1155             


His Thr  Ser Pro Asp Val Asp  Leu Gly Asp Ile Ser  Gly Ile Asn 
    1160                 1165                 1170             


Ala Ser  Val Val Asn Ile Gln  Lys Glu Ile Asp Arg  Leu Asn Glu 
    1175                 1180                 1185             


Val Ala  Lys Asn Leu Asn Glu  Ser Leu Ile Asp Leu  Gln Glu Leu 
    1190                 1195                 1200             


Gly Lys  Tyr Glu Gln Tyr Ile  Lys Trp Pro Trp Tyr  Ile Trp Leu 
    1205                 1210                 1215             


Gly Phe  Ile Ala Gly Leu Ile  Ala Ile Val Met Val  Thr Ile Met 
    1220                 1225                 1230             


Leu Cys  Cys Met Thr Ser Cys  Cys Ser Cys Leu Lys  Gly Cys Cys 
    1235                 1240                 1245             


Ser Cys  Gly Ser Cys Cys Lys  Phe Asp Glu Asp Asp  Ser Glu Pro 
    1250                 1255                 1260             


Val Leu  Lys Gly Val Lys Leu  His Tyr Thr 
    1265                 1270             


<210>  41
<211>  13
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  immunogenic peptide

<400>  41

Thr Glu Ser Ile Val Arg Phe Pro Asn Ile Thr Asn Leu 
1               5                   10              


<210>  42
<211>  16
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  immunogenic peptide

<400>  42

Asn Ile Thr Asn Leu Cys Pro Phe Gly Glu Val Phe Asn Ala Thr Arg 
1               5                   10                  15      


<210>  43
<211>  11
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  immunogenic peptide

<400>  43

Leu Tyr Asn Ser Ala Ser Phe Ser Thr Phe Lys 
1               5                   10      


<210>  44
<211>  10
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  immunogenic peptide

<400>  44

Leu Asp Ser Lys Val Gly Gly Asn Tyr Asn 
1               5                   10  


<210>  45
<211>  13
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  immunogenic peptide

<400>  45

Lys Ser Asn Leu Lys Pro Phe Glu Arg Asp Ile Ser Thr 
1               5                   10              


<210>  46
<211>  15
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  immunogenic peptide

<400>  46

Lys Pro Phe Glu Arg Asp Ile Ser Thr Glu Ile Tyr Gln Ala Gly 
1               5                   10                  15  


<210>  47
<211>  13
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  immunogenic peptide

<400>  47

Gly Pro Lys Lys Ser Thr Asn Leu Val Lys Asn Lys Cys 
1               5                   10              


<210>  48
<211>  14
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  immunogenic peptide

<400>  48

Asn Cys Asp Val Val Ile Gly Ile Val Asn Asn Thr Val Tyr 
1               5                   10                  


<210>  49
<211>  19
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  immunogenic peptide

<400>  49

Pro Glu Leu Asp Ser Phe Lys Glu Glu Leu Asp Lys Tyr Phe Lys Asn 
1               5                   10                  15      


His Thr Ser 
            


<210>  50
<211>  14
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  immunogenic peptide

<400>  50

Val Asn Ile Gln Lys Glu Ile Asp Arg Leu Asn Glu Val Ala 
1               5                   10                  


<210>  51
<211>  10
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  immunogenic peptide

<400>  51

Asn Leu Asn Glu Ser Leu Ile Asp Leu Gln 
1               5                   10  


<210>  52
<211>  11
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  immunogenic peptide

<400>  52

Leu Gly Lys Tyr Glu Gln Tyr Ile Lys Trp Pro 
1               5                   10      


