                         SEQUENCE LISTING

<110>  The Children's Hospital of Philadelphia
 
<120>  COMPOSITIONS AND METHODS USEFUL FOR THE TREATMENT OF H-ABC 
       LEUKODYSTROPHY

<130>  CHOP-132US00

<150>  US 63/175,998
<151>  2021-04-16

<160>  114   

<170>  PatentIn version 3.5

<210>  1
<211>  16
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  ASO H1


<220>
<221>  modified_base
<222>  (1)..(3)
<223>  2'-O-(2-Methoxyethyl)-oligori-bonucleotides

<220>
<221>  misc_feature
<222>  (1)..(16)
<223>  phosphorothioate bonds

<220>
<221>  modified_base
<222>  (14)..(16)
<223>  2'-O-(2-Methoxyethyl)-oligori-bonucleotides

<400>  1
uaggtctcat ccguau                                                       16


<210>  2
<211>  16
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  ASO H2


<220>
<221>  modified_base
<222>  (1)..(3)
<223>  2'-O-(2-Methoxyethyl)-oligori-bonucleotides

<220>
<221>  misc_feature
<222>  (1)..(16)
<223>  phosphorothioate bonds

<220>
<221>  modified_base
<222>  (14)..(16)
<223>  2'-O-(2-Methoxyethyl)-oligori-bonucleotides

<400>  2
ugcacgctca gcaucu                                                       16


<210>  3
<211>  15
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  ASO H3


<220>
<221>  misc_feature
<222>  (1)..(15)
<223>  phosphorothioate bonds

<220>
<221>  modified_base
<222>  (1)..(3)
<223>  2'-O-(2-Methoxyethyl)-oligori-bonucleotides

<220>
<221>  modified_base
<222>  (13)..(15)
<223>  2'-O-(2-Methoxyethyl)-oligori-bonucleotides

<400>  3
ucagaagcct cgagg                                                        15


<210>  4
<211>  17
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  ASO H4


<220>
<221>  modified_base
<222>  (1)..(4)
<223>  2'-O-(2-Methoxyethyl)-oligori-bonucleotides

<220>
<221>  misc_feature
<222>  (1)..(17)
<223>  phosphorothioate bonds

<220>
<221>  modified_base
<222>  (14)..(17)
<223>  2'-O-(2-Methoxyethyl)-oligori-bonucleotides

<400>  4
gagctccaaa ggtauug                                                      17


<210>  5
<211>  17
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  ASO H5


<220>
<221>  misc_feature
<222>  (1)..(17)
<223>  phosphorothioate bonds

<220>
<221>  modified_base
<222>  (1)..(4)
<223>  2'-O-(2-Methoxyethyl)-oligori-bonucleotides

<220>
<221>  modified_base
<222>  (14)..(17)
<223>  2'-O-(2-Methoxyethyl)-oligori-bonucleotides

<400>  5
gcgagctcca aagguau                                                      17


<210>  6
<211>  16
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  ASO H6


<220>
<221>  modified_base
<222>  (1)..(3)
<223>  2'-O-(2-Methoxyethyl)-oligori-bonucleotides

<220>
<221>  misc_feature
<222>  (1)..(16)
<223>  phosphorothioate bonds

<220>
<221>  modified_base
<222>  (14)..(16)
<223>  2'-O-(2-Methoxyethyl)-oligori-bonucleotides

<400>  6
agcgagctcc aaaggu                                                       16


<210>  7
<211>  16
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  ASO H7


<220>
<221>  misc_feature
<222>  (1)..(16)
<223>  phosphorothioate bonds

<220>
<221>  modified_base
<222>  (1)..(3)
<223>  2'-O-(2-Methoxyethyl)-oligori-bonucleotides

<220>
<221>  modified_base
<222>  (14)..(16)
<223>  2'-O-(2-Methoxyethyl)-oligori-bonucleotides

<400>  7
gguaaagcga gctcca                                                       16


<210>  8
<211>  17
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  ASO H8


<220>
<221>  modified_base
<222>  (1)..(4)
<223>  2'-O-(2-Methoxyethyl)-oligori-bonucleotides

<220>
<221>  misc_feature
<222>  (1)..(17)
<223>  phosphorothioate bonds

<220>
<221>  modified_base
<222>  (14)..(17)
<223>  2'-O-(2-Methoxyethyl)-oligori-bonucleotides

<400>  8
gccagaggta aagcgag                                                      17


<210>  9
<211>  15
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  ASO H9


<220>
<221>  modified_base
<222>  (1)..(3)
<223>  2'-O-(2-Methoxyethyl)-oligori-bonucleotides

<220>
<221>  misc_feature
<222>  (1)..(15)
<223>  phosphorothioate bonds

<220>
<221>  modified_base
<222>  (13)..(15)
<223>  2'-O-(2-Methoxyethyl)-oligori-bonucleotides

<400>  9
ggutaaaggt gaggc                                                        15


<210>  10
<211>  16
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  ASO H10


<220>
<221>  modified_base
<222>  (1)..(3)
<223>  2'-O-(2-Methoxyethyl)-oligori-bonucleotides

<220>
<221>  misc_feature
<222>  (1)..(16)
<223>  phosphorothioate bonds

<220>
<221>  modified_base
<222>  (14)..(16)
<223>  2'-O-(2-Methoxyethyl)-oligori-bonucleotides

<400>  10
ggacttgcag gtguag                                                       16


<210>  11
<211>  15
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  ASO H11


<220>
<221>  misc_feature
<222>  (1)..(15)
<223>  phosphorothioate bonds

<220>
<221>  modified_base
<222>  (1)..(3)
<223>  2'-O-(2-Methoxyethyl)-oligori-bonucleotides

<220>
<221>  modified_base
<222>  (13)..(15)
<223>  2'-O-(2-Methoxyethyl)-oligori-bonucleotides

<400>  11
gaactgcagc tcgga                                                        15


<210>  12
<211>  17
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  ASO H12


<220>
<221>  modified_base
<222>  (1)..(4)
<223>  2'-O-(2-Methoxyethyl)-oligori-bonucleotides

<220>
<221>  misc_feature
<222>  (1)..(17)
<223>  phosphorothioate bonds

<220>
<221>  modified_base
<222>  (14)..(17)
<223>  2'-O-(2-Methoxyethyl)-oligori-bonucleotides

<400>  12
aagctaaggt cggcagg                                                      17


<210>  13
<211>  18
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  ASO H13


<220>
<221>  misc_feature
<222>  (1)..(18)
<223>  phosphorothioate bonds

<220>
<221>  modified_base
<222>  (1)..(4)
<223>  2'-O-(2-Methoxyethyl)-oligori-bonucleotides

<220>
<221>  modified_base
<222>  (15)..(18)
<223>  2'-O-(2-Methoxyethyl)-oligori-bonucleotides

<400>  13
uaggtctcat ccgtauuc                                                     18


<210>  14
<211>  17
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  ASO H14


<220>
<221>  modified_base
<222>  (1)..(4)
<223>  2'-O-(2-Methoxyethyl)-oligori-bonucleotides

<220>
<221>  misc_feature
<222>  (1)..(17)
<223>  phosphorothioate bonds

<220>
<221>  modified_base
<222>  (14)..(17)
<223>  2'-O-(2-Methoxyethyl)-oligori-bonucleotides

<400>  14
guaggtctca tccguau                                                      17


<210>  15
<211>  15
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  ASO H15


<220>
<221>  misc_feature
<222>  (1)..(15)
<223>  phosphorothioate bonds

<220>
<221>  modified_base
<222>  (1)..(3)
<223>  2'-O-(2-Methoxyethyl)-oligori-bonucleotides

<220>
<221>  modified_base
<222>  (13)..(15)
<223>  2'-O-(2-Methoxyethyl)-oligori-bonucleotides

<400>  15
ggucagaagc ctcga                                                        15


<210>  16
<211>  18
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  ASO H16


<220>
<221>  modified_base
<222>  (1)..(4)
<223>  2'-O-(2-Methoxyethyl)-oligori-bonucleotides

<220>
<221>  misc_feature
<222>  (1)..(18)
<223>  phosphorothioate bonds

<220>
<221>  modified_base
<222>  (15)..(18)
<223>  2'-O-(2-Methoxyethyl)-oligori-bonucleotides

<400>  16
gcgagctcca aagguauu                                                     18


<210>  17
<211>  18
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  ASO H17


<220>
<221>  misc_feature
<222>  (1)..(18)
<223>  phosphorothioate bonds

<220>
<221>  modified_base
<222>  (1)..(4)
<223>  2'-O-(2-Methoxyethyl)-oligori-bonucleotides

<220>
<221>  modified_base
<222>  (15)..(18)
<223>  2'-O-(2-Methoxyethyl)-oligori-bonucleotides

<400>  17
agcgagctcc aaagguau                                                     18


<210>  18
<211>  17
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  ASO H18


<220>
<221>  modified_base
<222>  (1)..(4)
<223>  2'-O-(2-Methoxyethyl)-oligori-bonucleotides

<220>
<221>  misc_feature
<222>  (1)..(17)
<223>  phosphorothioate bonds

<220>
<221>  modified_base
<222>  (14)..(17)
<223>  2'-O-(2-Methoxyethyl)-oligori-bonucleotides

<400>  18
agcgagctcc aaaggua                                                      17


<210>  19
<211>  18
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  ASO H19


<220>
<221>  misc_feature
<222>  (1)..(18)
<223>  phosphorothioate bonds

<220>
<221>  modified_base
<222>  (1)..(4)
<223>  2'-O-(2-Methoxyethyl)-oligori-bonucleotides

<220>
<221>  modified_base
<222>  (15)..(18)
<223>  2'-O-(2-Methoxyethyl)-oligori-bonucleotides

<400>  19
aaagcgagct ccaaaggu                                                     18


<210>  20
<211>  17
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  ASO H20


<220>
<221>  modified_base
<222>  (1)..(4)
<223>  2'-O-(2-Methoxyethyl)-oligori-bonucleotides

<220>
<221>  misc_feature
<222>  (1)..(17)
<223>  phosphorothioate bonds

<220>
<221>  modified_base
<222>  (14)..(17)
<223>  2'-O-(2-Methoxyethyl)-oligori-bonucleotides

<400>  20
aaagcgagct ccaaagg                                                      17


<210>  21
<211>  17
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  ASO H21


<220>
<221>  misc_feature
<222>  (1)..(17)
<223>  phosphorothioate bonds

<220>
<221>  modified_base
<222>  (1)..(4)
<223>  2'-O-(2-Methoxyethyl)-oligori-bonucleotides

<220>
<221>  modified_base
<222>  (14)..(17)
<223>  2'-O-(2-Methoxyethyl)-oligori-bonucleotides

<400>  21
ggacttgcag gtguaga                                                      17


<210>  22
<211>  16
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  ASO H2A


<220>
<221>  modified_base
<222>  (1)..(4)
<223>  2'-O-(2-Methoxyethyl)-oligori-bonucleotides

<220>
<221>  misc_feature
<222>  (1)..(2)
<223>  phosphorothioate bonds

<220>
<221>  misc_feature
<222>  (5)..(13)
<223>  phosphorothioate bonds

<220>
<221>  modified_base
<222>  (5)..(5)
<223>  5'methyl

<220>
<221>  modified_base
<222>  (7)..(7)
<223>  5'methyl

<220>
<221>  modified_base
<222>  (9)..(9)
<223>  5'methyl

<220>
<221>  modified_base
<222>  (12)..(12)
<223>  5'methyl

<220>
<221>  modified_base
<222>  (13)..(16)
<223>  2'-O-(2-Methoxyethyl)-oligori-bonucleotides

<400>  22
ugcacgctca gcaucu                                                       16


<210>  23
<211>  16
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  ASO H2B


<220>
<221>  misc_feature
<222>  (1)..(2)
<223>  phosphorothioate bonds

<220>
<221>  modified_base
<222>  (1)..(4)
<223>  2'-O-(2-Methoxyethyl)-oligori-bonucleotides

<220>
<221>  modified_base
<222>  (5)..(5)
<223>  5'methyl

<220>
<221>  misc_feature
<222>  (5)..(13)
<223>  phosphorothioate bonds

<220>
<221>  modified_base
<222>  (7)..(7)
<223>  5'methyl

<220>
<221>  modified_base
<222>  (9)..(9)
<223>  5'methyl

<220>
<221>  modified_base
<222>  (12)..(12)
<223>  5'methyl

<220>
<221>  modified_base
<222>  (14)..(16)
<223>  2'-O-(2-Methoxyethyl)-oligori-bonucleotides

<220>
<221>  misc_feature
<222>  (15)..(16)
<223>  phosphorothioate bonds

<400>  23
ugcacgctca gcaucu                                                       16


<210>  24
<211>  16
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  ASO H10A


<220>
<221>  modified_base
<222>  (1)..(4)
<223>  2'-O-(2-Methoxyethyl)-oligori-bonucleotides

<220>
<221>  misc_feature
<222>  (1)..(2)
<223>  phosphorothioate bonds

<220>
<221>  misc_feature
<222>  (5)..(13)
<223>  phosphorothioate bonds

<220>
<221>  modified_base
<222>  (8)..(8)
<223>  5'methyl

<220>
<221>  modified_base
<222>  (13)..(16)
<223>  2'-O-(2-Methoxyethyl)-oligori-bonucleotides

<400>  24
ggacttgcag gtguag                                                       16


<210>  25
<211>  16
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  ASO H10B


<220>
<221>  misc_feature
<222>  (1)..(2)
<223>  phosphorothioate bonds

<220>
<221>  modified_base
<222>  (1)..(4)
<223>  2'-O-(2-Methoxyethyl)-oligori-bonucleotides

<220>
<221>  misc_feature
<222>  (5)..(13)
<223>  phosphorothioate bonds

<220>
<221>  modified_base
<222>  (8)..(8)
<223>  5'methyl

<220>
<221>  modified_base
<222>  (14)..(16)
<223>  2'-O-(2-Methoxyethyl)-oligori-bonucleotides

<220>
<221>  misc_feature
<222>  (15)..(16)
<223>  phosphorothioate bonds

<400>  25
ggacttgcag gtguag                                                       16


<210>  26
<211>  15
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  ASO H11A


<220>
<221>  modified_base
<222>  (1)..(3)
<223>  2'-O-(2-Methoxyethyl)-oligori-bonucleotides

<220>
<221>  misc_feature
<222>  (1)..(2)
<223>  phosphorothioate bonds

<220>
<221>  modified_base
<222>  (4)..(4)
<223>  5'methyl

<220>
<221>  misc_feature
<222>  (5)..(12)
<223>  phosphorothioate bonds

<220>
<221>  modified_base
<222>  (7)..(7)
<223>  5'methyl

<220>
<221>  modified_base
<222>  (10)..(10)
<223>  5'methyl

<220>
<221>  modified_base
<222>  (12)..(12)
<223>  5'methyl

<220>
<221>  modified_base
<222>  (13)..(15)
<223>  2'-O-(2-Methoxyethyl)-oligori-bonucleotides

<400>  26
gaactgcagc tcgga                                                        15


<210>  27
<211>  15
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  ASO H11B


<220>
<221>  misc_feature
<222>  (1)..(2)
<223>  phosphorothioate bonds

<220>
<221>  modified_base
<222>  (1)..(3)
<223>  2'-O-(2-Methoxyethyl)-oligori-bonucleotides

<220>
<221>  modified_base
<222>  (4)..(4)
<223>  5'methyl

<220>
<221>  misc_feature
<222>  (5)..(12)
<223>  phosphorothioate bonds

<220>
<221>  modified_base
<222>  (7)..(7)
<223>  5'methyl

<220>
<221>  modified_base
<222>  (10)..(10)
<223>  5'methyl

<220>
<221>  modified_base
<222>  (12)..(12)
<223>  5'methyl

<220>
<221>  modified_base
<222>  (13)..(15)
<223>  2'-O-(2-Methoxyethyl)-oligori-bonucleotides

<220>
<221>  misc_feature
<222>  (14)..(15)
<223>  phosphorothioate bonds

<400>  27
gaactgcagc tcgga                                                        15


<210>  28
<211>  15
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  ASO H15A


<220>
<221>  modified_base
<222>  (1)..(3)
<223>  2'-O-(2-Methoxyethyl)-oligori-bonucleotides

<220>
<221>  misc_feature
<222>  (1)..(2)
<223>  phosphorothioate bonds

<220>
<221>  modified_base
<222>  (4)..(4)
<223>  5'methyl

<220>
<221>  misc_feature
<222>  (5)..(12)
<223>  phosphorothioate bonds

<220>
<221>  modified_base
<222>  (10)..(11)
<223>  5'methyl

<220>
<221>  modified_base
<222>  (13)..(15)
<223>  2'-O-(2-Methoxyethyl)-oligori-bonucleotides

<400>  28
ggucagaagc ctcga                                                        15


<210>  29
<211>  15
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  ASO H15B


<220>
<221>  misc_feature
<222>  (1)..(2)
<223>  phosphorothioate bonds

<220>
<221>  modified_base
<222>  (1)..(3)
<223>  2'-O-(2-Methoxyethyl)-oligori-bonucleotides

<220>
<221>  modified_base
<222>  (4)..(4)
<223>  5'methyl

<220>
<221>  misc_feature
<222>  (5)..(12)
<223>  phosphorothioate bonds

<220>
<221>  modified_base
<222>  (10)..(11)
<223>  5'methyl

<220>
<221>  modified_base
<222>  (13)..(15)
<223>  2'-O-(2-Methoxyethyl)-oligori-bonucleotides

<220>
<221>  misc_feature
<222>  (14)..(15)
<223>  phosphorothioate bonds

<400>  29
ggucagaagc ctcga                                                        15


<210>  30
<211>  17
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  ASO 1


<220>
<221>  modified_base
<222>  (1)..(4)
<223>  2'-O-(2-Methoxyethyl)-oligori-bonucleotides

<220>
<221>  misc_feature
<222>  (1)..(17)
<223>  phosphorothioate bonds

<220>
<221>  modified_base
<222>  (14)..(17)
<223>  2'-O-(2-Methoxyethyl)-oligori-bonucleotides

<400>  30
gcuugcaggt gcacgau                                                      17


<210>  31
<211>  17
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  ASO 2


<220>
<221>  misc_feature
<222>  (1)..(17)
<223>  phosphorothioate bonds

<220>
<221>  modified_base
<222>  (1)..(4)
<223>  2'-O-(2-Methoxyethyl)-oligori-bonucleotides

<220>
<221>  modified_base
<222>  (14)..(17)
<223>  2'-O-(2-Methoxyethyl)-oligori-bonucleotides

<400>  31
ugucgatgca gtagguc                                                      17


<210>  32
<211>  16
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  ASO 3


<220>
<221>  modified_base
<222>  (1)..(3)
<223>  2'-O-(2-Methoxyethyl)-oligori-bonucleotides

<220>
<221>  misc_feature
<222>  (1)..(16)
<223>  phosphorothioate bonds

<220>
<221>  modified_base
<222>  (14)..(16)
<223>  2'-O-(2-Methoxyethyl)-oligori-bonucleotides

<400>  32
ugucgatgca gtaggu                                                       16


<210>  33
<211>  17
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  ASO 4


<220>
<221>  misc_feature
<222>  (1)..(17)
<223>  phosphorothioate bonds

<220>
<221>  modified_base
<222>  (1)..(4)
<223>  2'-O-(2-Methoxyethyl)-oligori-bonucleotides

<220>
<221>  modified_base
<222>  (14)..(17)
<223>  2'-O-(2-Methoxyethyl)-oligori-bonucleotides

<400>  33
ccucgttgtc gatgcag                                                      17


<210>  34
<211>  17
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  ASO 5


<220>
<221>  modified_base
<222>  (1)..(4)
<223>  2'-O-(2-Methoxyethyl)-oligori-bonucleotides

<220>
<221>  misc_feature
<222>  (1)..(17)
<223>  * phosphorothioate bonds

<220>
<221>  modified_base
<222>  (14)..(17)
<223>  2'-O-(2-Methoxyethyl)-oligori-bonucleotides

<400>  34
uugaggtccc cgtaggu                                                      17


<210>  35
<211>  17
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  ASO 6


<220>
<221>  misc_feature
<222>  (1)..(17)
<223>  phosphorothioate bonds

<220>
<221>  modified_base
<222>  (1)..(4)
<223>  2'-O-(2-Methoxyethyl)-oligori-bonucleotides

<220>
<221>  modified_base
<222>  (14)..(17)
<223>  2'-O-(2-Methoxyethyl)-oligori-bonucleotides

<400>  35
gcucgtctac ctccuuc                                                      17


<210>  36
<211>  16
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  ASO 7


<220>
<221>  modified_base
<222>  (1)..(3)
<223>  2'-O-(2-Methoxyethyl)-oligori-bonucleotides

<220>
<221>  misc_feature
<222>  (1)..(16)
<223>  phosphorothioate bonds

<220>
<221>  modified_base
<222>  (14)..(16)
<223>  2'-O-(2-Methoxyethyl)-oligori-bonucleotides

<400>  36
gcucgtctac ctccuu                                                       16


<210>  37
<211>  16
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  ASO 8


<220>
<221>  misc_feature
<222>  (1)..(16)
<223>  phosphorothioate bonds

<220>
<221>  modified_base
<222>  (1)..(3)
<223>  2'-O-(2-Methoxyethyl)-oligori-bonucleotides

<220>
<221>  modified_base
<222>  (14)..(16)
<223>  2'-O-(2-Methoxyethyl)-oligori-bonucleotides

<400>  37
ugctcgtcta cctccu                                                       16


<210>  38
<211>  17
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  ASO 9


<220>
<221>  modified_base
<222>  (1)..(4)
<223>  2'-O-(2-Methoxyethyl)-oligori-bonucleotides

<220>
<221>  misc_feature
<222>  (1)..(17)
<223>  phosphorothioate bonds

<220>
<221>  modified_base
<222>  (14)..(17)
<223>  2'-O-(2-Methoxyethyl)-oligori-bonucleotides

<400>  38
ucucgtccat gccuucg                                                      17


<210>  39
<211>  17
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  ASO 10


<220>
<221>  misc_feature
<222>  (1)..(17)
<223>  phosphorothioate bonds

<220>
<221>  modified_base
<222>  (1)..(4)
<223>  2'-O-(2-Methoxyethyl)-oligori-bonucleotides

<220>
<221>  modified_base
<222>  (14)..(17)
<223>  2'-O-(2-Methoxyethyl)-oligori-bonucleotides

<400>  39
ccauctcgtc catgccu                                                      17


<210>  40
<211>  17
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  ASO 11


<220>
<221>  modified_base
<222>  (1)..(4)
<223>  2'-O-(2-Methoxyethyl)-oligori-bonucleotides

<220>
<221>  misc_feature
<222>  (1)..(17)
<223>  phosphorothioate bonds

<220>
<221>  modified_base
<222>  (14)..(17)
<223>  2'-O-(2-Methoxyethyl)-oligori-bonucleotides

<400>  40
ucuucgaact cgcccuc                                                      17


<210>  41
<211>  16
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  ASO 12


<220>
<221>  misc_feature
<222>  (1)..(16)
<223>  phosphorothioate bonds

<220>
<221>  modified_base
<222>  (1)..(3)
<223>  2'-O-(2-Methoxyethyl)-oligori-bonucleotides

<220>
<221>  modified_base
<222>  (14)..(16)
<223>  2'-O-(2-Methoxyethyl)-oligori-bonucleotides

<400>  41
ccucctcttc gaacuc                                                       16


<210>  42
<211>  15
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  ASO 13


<220>
<221>  modified_base
<222>  (1)..(3)
<223>  2'-O-(2-Methoxyethyl)-oligori-bonucleotides

<220>
<221>  modified_base
<222>  (13)..(15)
<223>  2'-O-(2-Methoxyethyl)-oligori-bonucleotides

<220>
<221>  misc_feature
<222>  (13)..(15)
<223>  phosphorothioate bonds

<400>  42
ggucagaggt aaggc                                                        15


<210>  43
<211>  17
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  ASO 14


<220>
<221>  misc_feature
<222>  (1)..(17)
<223>  phosphorothioate bonds

<220>
<221>  modified_base
<222>  (1)..(4)
<223>  2'-O-(2-Methoxyethyl)-oligori-bonucleotides

<220>
<221>  modified_base
<222>  (14)..(17)
<223>  2'-O-(2-Methoxyethyl)-oligori-bonucleotides

<400>  43
ugcacgattt cccgcau                                                      17


<210>  44
<211>  17
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  ASO 15


<220>
<221>  modified_base
<222>  (1)..(4)
<223>  2'-O-(2-Methoxyethyl)-oligori-bonucleotides

<220>
<221>  misc_feature
<222>  (1)..(17)
<223>  phosphorothioate bonds

<220>
<221>  modified_base
<222>  (14)..(17)
<223>  2'-O-(2-Methoxyethyl)-oligori-bonucleotides

<400>  44
guugtcgatg caguagg                                                      17


<210>  45
<211>  19
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  ASO 16


<220>
<221>  misc_feature
<222>  (1)..(19)
<223>  phosphorothioate bonds

<220>
<221>  modified_base
<222>  (1)..(5)
<223>  2'-O-(2-Methoxyethyl)-oligori-bonucleotides

<220>
<221>  modified_base
<222>  (16)..(19)
<223>  2'-O-(2-Methoxyethyl)-oligori-bonucleotides

<400>  45
ccucgttgtc gatgcagua                                                    19


<210>  46
<211>  17
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  ASO 17


<220>
<221>  modified_base
<222>  (1)..(4)
<223>  2'-O-(2-Methoxyethyl)-oligori-bonucleotides

<220>
<221>  misc_feature
<222>  (1)..(17)
<223>  phosphorothioate bonds

<220>
<221>  modified_base
<222>  (15)..(17)
<223>  2'-O-(2-Methoxyethyl)-oligori-bonucleotides

<400>  46
cucgttgtcg atgcagu                                                      17


<210>  47
<211>  15
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  ASO 18


<220>
<221>  misc_feature
<222>  (1)..(15)
<223>  phosphorothioate bonds

<220>
<221>  modified_base
<222>  (1)..(3)
<223>  2'-O-(2-Methoxyethyl)-oligori-bonucleotides

<220>
<221>  modified_base
<222>  (13)..(15)
<223>  2'-O-(2-Methoxyethyl)-oligori-bonucleotides

<400>  47
ugctcgtcta ccucc                                                        15


<210>  48
<211>  18
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  ASO 19


<220>
<221>  modified_base
<222>  (1)..(4)
<223>  2'-O-(2-Methoxyethyl)-oligori-bonucleotides

<220>
<221>  modified_base
<222>  (15)..(18)
<223>  2'-O-(2-Methoxyethyl)-oligori-bonucleotides

<220>
<221>  misc_feature
<222>  (15)..(18)
<223>  phosphorothioate bonds

<400>  48
gugctgttgc cgatgaag                                                     18


<210>  49
<211>  16
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  ASO 20


<220>
<221>  misc_feature
<222>  (1)..(16)
<223>  phosphorothioate bonds

<220>
<221>  modified_base
<222>  (1)..(3)
<223>  2'-O-(2-Methoxyethyl)-oligori-bonucleotides

<220>
<221>  modified_base
<222>  (14)..(16)
<223>  2'-O-(2-Methoxyethyl)-oligori-bonucleotides

<400>  49
gugctgttgc cgauga                                                       16


<210>  50
<211>  19
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  ASO 21


<220>
<221>  modified_base
<222>  (1)..(5)
<223>  2'-O-(2-Methoxyethyl)-oligori-bonucleotides

<220>
<221>  misc_feature
<222>  (1)..(19)
<223>  phosphorothioate bonds

<220>
<221>  modified_base
<222>  (16)..(19)
<223>  2'-O-(2-Methoxyethyl)-oligori-bonucleotides

<400>  50
aucucgtcca tgcctucgc                                                    19


<210>  51
<211>  18
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  ASO 22


<220>
<221>  misc_feature
<222>  (1)..(18)
<223>  phosphorothioate bonds

<220>
<221>  modified_base
<222>  (1)..(4)
<223>  2'-O-(2-Methoxyethyl)-oligori-bonucleotides

<220>
<221>  modified_base
<222>  (15)..(18)
<223>  2'-O-(2-Methoxyethyl)-oligori-bonucleotides

<400>  51
ccauctcgtc catgccuu                                                     18


<210>  52
<211>  17
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  ASO 23


<220>
<221>  modified_base
<222>  (1)..(4)
<223>  2'-O-(2-Methoxyethyl)-oligori-bonucleotides

<220>
<221>  misc_feature
<222>  (1)..(17)
<223>  phosphorothioate bonds

<220>
<221>  modified_base
<222>  (14)..(17)
<223>  2'-O-(2-Methoxyethyl)-oligori-bonucleotides

<400>  52
uccatctcgt ccaugcc                                                      17


<210>  53
<211>  16
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  ASO 24


<220>
<221>  misc_feature
<222>  (1)..(16)
<223>  phosphorothioate bonds

<220>
<221>  modified_base
<222>  (1)..(3)
<223>  2'-O-(2-Methoxyethyl)-oligori-bonucleotides

<220>
<221>  modified_base
<222>  (14)..(16)
<223>  2'-O-(2-Methoxyethyl)-oligori-bonucleotides

<400>  53
uucgaactcg cccucu                                                       16


<210>  54
<211>  17
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  ASO 25


<220>
<221>  modified_base
<222>  (1)..(4)
<223>  2'-O-(2-Methoxyethyl)-oligori-bonucleotides

<220>
<221>  modified_base
<222>  (14)..(17)
<223>  2'-O-(2-Methoxyethyl)-oligori-bonucleotides

<220>
<221>  misc_feature
<222>  (14)..(17)
<223>  phosphorothioate bonds

<400>  54
cucutcgaac tcgcccu                                                      17


<210>  55
<211>  17
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  ASO 4A


<220>
<221>  misc_feature
<222>  (1)..(2)
<223>  phosphorothioate bonds

<220>
<221>  modified_base
<222>  (1)..(4)
<223>  2'-O-(2-Methoxyethyl)-oligori-bonucleotides

<220>
<221>  misc_feature
<222>  (5)..(14)
<223>  phosphorothioate bonds

<220>
<221>  modified_base
<222>  (10)..(10)
<223>  5'methyl

<220>
<221>  modified_base
<222>  (14)..(17)
<223>  2'-O-(2-Methoxyethyl)-oligori-bonucleotides

<400>  55
ccucgttgtc gatgcag                                                      17


<210>  56
<211>  17
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  ASO 4B


<220>
<221>  modified_base
<222>  (1)..(4)
<223>  2'-O-(2-Methoxyethyl)-oligori-bonucleotides

<220>
<221>  misc_feature
<222>  (1)..(2)
<223>  phosphorothioate bonds

<220>
<221>  misc_feature
<222>  (5)..(14)
<223>  phosphorothioate bonds

<220>
<221>  modified_base
<222>  (10)..(10)
<223>  5'methyl

<220>
<221>  modified_base
<222>  (14)..(17)
<223>  2'-O-(2-Methoxyethyl)-oligori-bonucleotides

<220>
<221>  misc_feature
<222>  (16)..(17)
<223>  phosphorothioate bonds

<400>  56
ccucgttgtc gatgcag                                                      17


<210>  57
<211>  17
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  ASO 6A


<220>
<221>  misc_feature
<222>  (1)..(2)
<223>  phosphorothioate bonds

<220>
<221>  modified_base
<222>  (1)..(4)
<223>  2'-O-(2-Methoxyethyl)-oligori-bonucleotides

<220>
<221>  misc_feature
<222>  (5)..(14)
<223>  phosphorothioate bonds

<220>
<221>  modified_base
<222>  (7)..(7)
<223>  5'methyl

<220>
<221>  modified_base
<222>  (10)..(11)
<223>  5'methyl

<220>
<221>  modified_base
<222>  (14)..(17)
<223>  2'-O-(2-Methoxyethyl)-oligori-bonucleotides

<400>  57
gcucgtctac ctccuuc                                                      17


<210>  58
<211>  17
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  ASO 6B


<220>
<221>  modified_base
<222>  (1)..(4)
<223>  2'-O-(2-Methoxyethyl)-oligori-bonucleotides

<220>
<221>  misc_feature
<222>  (1)..(2)
<223>  phosphorothioate bonds

<220>
<221>  misc_feature
<222>  (5)..(14)
<223>  phosphorothioate bonds

<220>
<221>  modified_base
<222>  (7)..(7)
<223>  5'methyl

<220>
<221>  modified_base
<222>  (10)..(11)
<223>  5'methyl

<220>
<221>  modified_base
<222>  (14)..(17)
<223>  2'-O-(2-Methoxyethyl)-oligori-bonucleotides

<220>
<221>  misc_feature
<222>  (16)..(17)
<223>  phosphorothioate bonds

<400>  58
gcucgtctac ctccuuc                                                      17


<210>  59
<211>  16
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  ASO 7A


<220>
<221>  misc_feature
<222>  (1)..(2)
<223>  phosphorothioate bonds

<220>
<221>  modified_base
<222>  (1)..(4)
<223>  2'-O-(2-Methoxyethyl)-oligori-bonucleotides

<220>
<221>  misc_feature
<222>  (5)..(13)
<223>  phosphorothioate bonds

<220>
<221>  modified_base
<222>  (7)..(7)
<223>  5'methyl

<220>
<221>  modified_base
<222>  (10)..(11)
<223>  5'methyl

<220>
<221>  modified_base
<222>  (13)..(13)
<223>  5'methyl

<220>
<221>  modified_base
<222>  (14)..(16)
<223>  2'-O-(2-Methoxyethyl)-oligori-bonucleotides

<400>  59
gcucgtctac ctccuu                                                       16


<210>  60
<211>  16
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  ASO 7B


<220>
<221>  modified_base
<222>  (1)..(4)
<223>  2'-O-(2-Methoxyethyl)-oligori-bonucleotides

<220>
<221>  misc_feature
<222>  (1)..(2)
<223>  phosphorothioate bonds

<220>
<221>  misc_feature
<222>  (5)..(13)
<223>  phosphorothioate bonds

<220>
<221>  modified_base
<222>  (7)..(7)
<223>  5'methyl

<220>
<221>  modified_base
<222>  (10)..(11)
<223>  5'methyl

<220>
<221>  modified_base
<222>  (13)..(13)
<223>  5'methyl

<220>
<221>  modified_base
<222>  (14)..(16)
<223>  2'-O-(2-Methoxyethyl)-oligori-bonucleotides

<220>
<221>  misc_feature
<222>  (15)..(16)
<223>  phosphorothioate bonds

<400>  60
gcucgtctac ctccuu                                                       16


<210>  61
<211>  16
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  NTC Control


<220>
<221>  misc_feature
<222>  (1)..(2)
<223>  phosphorothioate bonds

<220>
<221>  modified_base
<222>  (1)..(4)
<223>  2'-O-(2-Methoxyethyl)-oligori-bonucleotides

<220>
<221>  misc_feature
<222>  (5)..(13)
<223>  phosphorothioate bonds

<220>
<221>  modified_base
<222>  (5)..(5)
<223>  5'methyl

<220>
<221>  modified_base
<222>  (13)..(16)
<223>  2'-O-(2-Methoxyethyl)-oligori-bonucleotides

<220>
<221>  misc_feature
<222>  (15)..(16)
<223>  phosphorothioate bonds

<400>  61
uacgcgacuu augcgg                                                       16


<210>  62
<211>  16
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  ASO H2-1


<220>
<221>  misc_feature
<222>  (1)..(3)
<223>  2'-O-(2-Methoxyethyl)-oligori-bonucleotides

<220>
<221>  misc_feature
<222>  (1)..(15)
<223>  phosphorothioate bonds

<220>
<221>  misc_feature
<222>  (3)..(3)
<223>  5'methyl

<220>
<221>  misc_feature
<222>  (5)..(5)
<223>  5'methyl

<220>
<221>  misc_feature
<222>  (7)..(7)
<223>  5'methyl

<220>
<221>  misc_feature
<222>  (9)..(9)
<223>  5'methyl

<220>
<221>  misc_feature
<222>  (12)..(12)
<223>  5'methyl

<220>
<221>  misc_feature
<222>  (14)..(16)
<223>  2'-O-(2-Methoxyethyl)-oligori-bonucleotides

<220>
<221>  misc_feature
<222>  (15)..(15)
<223>  5'methyl

<400>  62
ugcacgctca gcaucu                                                       16


<210>  63
<211>  16
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  ASO H2-2


<220>
<221>  misc_feature
<222>  (1)..(1)
<223>  2'-O-(2-Methoxyethyl)-oligori-bonucleotides

<220>
<221>  misc_feature
<222>  (1)..(15)
<223>  phosphorothioate bonds

<220>
<221>  misc_feature
<222>  (2)..(2)
<223>  locked nucleic acid

<220>
<221>  misc_feature
<222>  (3)..(3)
<223>  2'-O-(2-Methoxyethyl)-oligori-bonucleotides

<220>
<221>  misc_feature
<222>  (3)..(3)
<223>  5'methyl

<220>
<221>  misc_feature
<222>  (5)..(5)
<223>  5'methyl

<220>
<221>  misc_feature
<222>  (7)..(7)
<223>  5'methyl

<220>
<221>  misc_feature
<222>  (9)..(9)
<223>  5'methyl

<220>
<221>  misc_feature
<222>  (12)..(12)
<223>  5'methyl

<220>
<221>  misc_feature
<222>  (14)..(14)
<223>  2'-O-(2-Methoxyethyl)-oligori-bonucleotides

<220>
<221>  misc_feature
<222>  (15)..(15)
<223>  5'methyl

<220>
<221>  misc_feature
<222>  (15)..(15)
<223>  locked nucleic acid

<220>
<221>  misc_feature
<222>  (16)..(16)
<223>  2'-O-(2-Methoxyethyl)-oligori-bonucleotides

<400>  63
ugcacgctca gcaucu                                                       16


<210>  64
<211>  16
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  ASO H2-3


<220>
<221>  misc_feature
<222>  (1)..(3)
<223>  locked nucleic acid

<220>
<221>  misc_feature
<222>  (1)..(16)
<223>  phosphorothioate bonds

<220>
<221>  misc_feature
<222>  (3)..(3)
<223>  5'methyl

<220>
<221>  misc_feature
<222>  (5)..(5)
<223>  5'methyl

<220>
<221>  misc_feature
<222>  (7)..(7)
<223>  5'methyl

<220>
<221>  misc_feature
<222>  (9)..(9)
<223>  5'methyl

<220>
<221>  misc_feature
<222>  (12)..(12)
<223>  5'methyl

<220>
<221>  misc_feature
<222>  (15)..(17)
<223>  locked nucleic acid

<220>
<221>  misc_feature
<222>  (16)..(16)
<223>  5'methyl

<400>  64
ugcacgctca gcaucu                                                       16


<210>  65
<211>  18
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  ASO H2-4


<220>
<221>  misc_feature
<222>  (1)..(4)
<223>  2'-O-(2-Methoxyethyl)-oligori-bonucleotides

<220>
<221>  misc_feature
<222>  (1)..(17)
<223>  phosphorothioate bonds

<220>
<221>  misc_feature
<222>  (1)..(1)
<223>  5'methyl

<220>
<221>  misc_feature
<222>  (4)..(4)
<223>  5'methyl

<220>
<221>  misc_feature
<222>  (6)..(6)
<223>  5'methyl

<220>
<221>  misc_feature
<222>  (8)..(8)
<223>  5'methyl

<220>
<221>  misc_feature
<222>  (10)..(10)
<223>  5'methyl

<220>
<221>  misc_feature
<222>  (13)..(13)
<223>  5'methyl

<220>
<221>  misc_feature
<222>  (15)..(18)
<223>  2'-O-(2-Methoxyethyl)-oligori-bonucleotides

<220>
<221>  misc_feature
<222>  (16)..(16)
<223>  5'methyl

<400>  65
cugcacgctc agcaucug                                                     18


<210>  66
<211>  16
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  ASO H10-1


<220>
<221>  misc_feature
<222>  (1)..(3)
<223>  2'-O-(2-Methoxyethyl)-oligori-bonucleotides

<220>
<221>  misc_feature
<222>  (1)..(15)
<223>  phosphorothioate bonds

<220>
<221>  misc_feature
<222>  (4)..(4)
<223>  5'methyl

<220>
<221>  misc_feature
<222>  (8)..(8)
<223>  5'methyl

<220>
<221>  misc_feature
<222>  (14)..(16)
<223>  2'-O-(2-Methoxyethyl)-oligori-bonucleotides

<400>  66
ggacttgcag gtguag                                                       16


<210>  67
<211>  16
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  ASO H10-2


<220>
<221>  misc_feature
<222>  (1)..(3)
<223>  locked nucleic acid

<220>
<221>  misc_feature
<222>  (1)..(1)
<223>  phosphorothioate bonds

<220>
<221>  misc_feature
<222>  (3)..(13)
<223>  phosphorothioate bonds

<220>
<221>  misc_feature
<222>  (4)..(4)
<223>  5'methyl

<220>
<221>  misc_feature
<222>  (8)..(8)
<223>  5'methyl

<220>
<221>  misc_feature
<222>  (14)..(16)
<223>  locked nucleic acid

<220>
<221>  misc_feature
<222>  (15)..(16)
<223>  phosphorothioate bonds

<400>  67
ggacttgcag gtguag                                                       16


<210>  68
<211>  18
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  ASO H10-3


<220>
<221>  misc_feature
<222>  (1)..(4)
<223>  2'-O-(2-Methoxyethyl)-oligori-bonucleotides

<220>
<221>  misc_feature
<222>  (1)..(2)
<223>  2'-O-(2-Methoxyethyl)-oligori-bonucleotides

<220>
<221>  misc_feature
<222>  (4)..(15)
<223>  2'-O-(2-Methoxyethyl)-oligori-bonucleotides

<220>
<221>  misc_feature
<222>  (5)..(5)
<223>  5'methyl

<220>
<221>  misc_feature
<222>  (9)..(9)
<223>  5'methyl

<220>
<221>  misc_feature
<222>  (15)..(18)
<223>  2'-O-(2-Methoxyethyl)-oligori-bonucleotides

<220>
<221>  misc_feature
<222>  (17)..(18)
<223>  2'-O-(2-Methoxyethyl)-oligori-bonucleotides

<400>  68
aggacttgca ggtguaga                                                     18


<210>  69
<211>  16
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  ASO H10-4


<220>
<221>  misc_feature
<222>  (1)..(3)
<223>  locked nucleic acid

<220>
<221>  misc_feature
<222>  (3)..(14)
<223>  phosphorothioate bonds

<220>
<221>  misc_feature
<222>  (4)..(4)
<223>  5'methyl

<220>
<221>  misc_feature
<222>  (8)..(8)
<223>  5'methyl

<220>
<221>  misc_feature
<222>  (14)..(16)
<223>  locked nucleic acid

<400>  69
ggacttgcag gtguag                                                       16


<210>  70
<211>  15
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  ASO H11-1


<220>
<221>  misc_feature
<222>  (1)..(3)
<223>  2'-O-(2-Methoxyethyl)-oligori-bonucleotides

<220>
<221>  misc_feature
<222>  (1)..(13)
<223>  phosphorothioate bonds

<220>
<221>  misc_feature
<222>  (4)..(4)
<223>  5'methyl

<220>
<221>  misc_feature
<222>  (7)..(7)
<223>  5'methyl

<220>
<221>  misc_feature
<222>  (10)..(10)
<223>  5'methyl

<220>
<221>  misc_feature
<222>  (12)..(12)
<223>  5'methyl

<220>
<221>  misc_feature
<222>  (13)..(15)
<223>  2'-O-(2-Methoxyethyl)-oligori-bonucleotides

<400>  70
gaactgcagc tcgga                                                        15


<210>  71
<211>  15
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  ASO H11-2


<220>
<221>  misc_feature
<222>  (1)..(14)
<223>  phosphorothioate bonds

<220>
<221>  misc_feature
<222>  (1)..(1)
<223>  locked nucleic acid

<220>
<221>  misc_feature
<222>  (2)..(3)
<223>  2'-O-(2-Methoxyethyl)-oligori-bonucleotides

<220>
<221>  misc_feature
<222>  (4)..(4)
<223>  5'methyl

<220>
<221>  misc_feature
<222>  (7)..(7)
<223>  5'methyl

<220>
<221>  misc_feature
<222>  (10)..(10)
<223>  5'methyl

<220>
<221>  misc_feature
<222>  (12)..(12)
<223>  5'methyl

<220>
<221>  misc_feature
<222>  (13)..(14)
<223>  2'-O-(2-Methoxyethyl)-oligori-bonucleotides

<220>
<221>  misc_feature
<222>  (15)..(15)
<223>  locked nucleic acid

<400>  71
gaactgcagc tcgga                                                        15


<210>  72
<211>  17
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  ASO H11-3


<220>
<221>  misc_feature
<222>  (1)..(16)
<223>  phosphorothioate bonds

<220>
<221>  misc_feature
<222>  (1)..(1)
<223>  locked nucleic acid

<220>
<221>  misc_feature
<222>  (2)..(4)
<223>  2'-O-(2-Methoxyethyl)-oligori-bonucleotides

<220>
<221>  misc_feature
<222>  (5)..(5)
<223>  5'methyl

<220>
<221>  misc_feature
<222>  (8)..(8)
<223>  5'methyl

<220>
<221>  misc_feature
<222>  (11)..(11)
<223>  5'methyl

<220>
<221>  misc_feature
<222>  (13)..(13)
<223>  5'methyl

<220>
<221>  misc_feature
<222>  (14)..(16)
<223>  2'-O-(2-Methoxyethyl)-oligori-bonucleotides

<220>
<221>  misc_feature
<222>  (17)..(17)
<223>  locked nucleic acid

<400>  72
ugaactgcag ctcggag                                                      17


<210>  73
<211>  17
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  ASO H14-1


<220>
<221>  misc_feature
<222>  (1)..(4)
<223>  2'-O-(2-Methoxyethyl)-oligori-bonucleotides

<220>
<221>  misc_feature
<222>  (4)..(14)
<223>  phosphorothioate bonds

<220>
<221>  misc_feature
<222>  (7)..(7)
<223>  5'methyl

<220>
<221>  misc_feature
<222>  (9)..(9)
<223>  5'methyl

<220>
<221>  misc_feature
<222>  (12)..(13)
<223>  5'methyl

<220>
<221>  misc_feature
<222>  (14)..(17)
<223>  2'-O-(2-Methoxyethyl)-oligori-bonucleotides

<400>  73
guaggtctca tccguau                                                      17


<210>  74
<211>  15
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  ASO H15-1


<220>
<221>  misc_feature
<222>  (1)..(3)
<223>  2'-O-(2-Methoxyethyl)-oligori-bonucleotides

<220>
<221>  misc_feature
<222>  (1)..(14)
<223>  phosphorothioate bonds

<220>
<221>  misc_feature
<222>  (4)..(4)
<223>  5'methyl

<220>
<221>  misc_feature
<222>  (10)..(11)
<223>  5'methyl

<220>
<221>  misc_feature
<222>  (13)..(13)
<223>  5'methyl

<220>
<221>  misc_feature
<222>  (13)..(15)
<223>  2'-O-(2-Methoxyethyl)-oligori-bonucleotides

<400>  74
ggucagaagc ctcga                                                        15


<210>  75
<211>  15
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  ASO H15-2


<220>
<221>  misc_feature
<222>  (1)..(14)
<223>  phosphorothioate bonds

<220>
<221>  misc_feature
<222>  (1)..(2)
<223>  locked nucleic acid

<220>
<221>  misc_feature
<222>  (3)..(3)
<223>  2'-O-(2-Methoxyethyl)-oligori-bonucleotides

<220>
<221>  misc_feature
<222>  (4)..(4)
<223>  5'methyl

<220>
<221>  misc_feature
<222>  (10)..(11)
<223>  5'methyl

<220>
<221>  misc_feature
<222>  (13)..(13)
<223>  5'methyl

<220>
<221>  misc_feature
<222>  (13)..(13)
<223>  2'-O-(2-Methoxyethyl)-oligori-bonucleotides

<220>
<221>  misc_feature
<222>  (14)..(15)
<223>  locked nucleic acid

<400>  75
ggucagaagc ctcga                                                        15


<210>  76
<211>  19
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  ASO H15-3


<220>
<221>  misc_feature
<222>  (1)..(5)
<223>  2'-O-(2-Methoxyethyl)-oligori-bonucleotides

<220>
<221>  misc_feature
<222>  (1)..(18)
<223>  phosphorothioate bonds

<220>
<221>  misc_feature
<222>  (6)..(6)
<223>  5'methyl

<220>
<221>  misc_feature
<222>  (12)..(13)
<223>  5'methyl

<220>
<221>  misc_feature
<222>  (15)..(15)
<223>  5'methyl

<220>
<221>  misc_feature
<222>  (15)..(19)
<223>  2'-O-(2-Methoxyethyl)-oligori-bonucleotides

<400>  76
aaggucagaa gcctcgagg                                                    19


<210>  77
<211>  15
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  ASO H15-4


<220>
<221>  misc_feature
<222>  (1)..(3)
<223>  2'-O-(2-Methoxyethyl)-oligori-bonucleotides

<220>
<221>  misc_feature
<222>  (4)..(13)
<223>  phosphorothioate bonds

<220>
<221>  misc_feature
<222>  (4)..(4)
<223>  5'methyl

<220>
<221>  misc_feature
<222>  (10)..(11)
<223>  5'methyl

<220>
<221>  misc_feature
<222>  (13)..(13)
<223>  5'methyl

<220>
<221>  misc_feature
<222>  (13)..(15)
<223>  2'-O-(2-Methoxyethyl)-oligori-bonucleotides

<400>  77
ggucagaagc ctcga                                                        15


<210>  78
<211>  16
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  ASO H22


<220>
<221>  misc_feature
<222>  (1)..(3)
<223>  locked nucleic acid

<220>
<221>  misc_feature
<222>  (2)..(2)
<223>  5'methyl

<220>
<221>  misc_feature
<222>  (4)..(13)
<223>  phosphorothioate bonds

<220>
<221>  misc_feature
<222>  (4)..(4)
<223>  5'methyl

<220>
<221>  misc_feature
<222>  (6)..(6)
<223>  5'methyl

<220>
<221>  misc_feature
<222>  (8)..(8)
<223>  5'methyl

<220>
<221>  misc_feature
<222>  (11)..(11)
<223>  5'methyl

<220>
<221>  misc_feature
<222>  (14)..(14)
<223>  5'methyl

<220>
<221>  misc_feature
<222>  (14)..(16)
<223>  locked nucleic acid

<400>  78
gcacgctcag catctg                                                       16


<210>  79
<211>  19
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  ASO H23


<220>
<221>  misc_feature
<222>  (1)..(5)
<223>  locked nucleic acid

<220>
<221>  misc_feature
<222>  (1)..(1)
<223>  5'methyl

<220>
<221>  misc_feature
<222>  (3)..(3)
<223>  5'methyl

<220>
<221>  misc_feature
<222>  (5)..(13)
<223>  phosphorothioate bonds

<220>
<221>  misc_feature
<222>  (6)..(6)
<223>  5'methyl

<220>
<221>  misc_feature
<222>  (8)..(8)
<223>  5'methyl

<220>
<221>  misc_feature
<222>  (10)..(10)
<223>  5'methyl

<220>
<221>  misc_feature
<222>  (12)..(12)
<223>  5'methyl

<220>
<221>  misc_feature
<222>  (15)..(15)
<223>  5'methyl

<220>
<221>  misc_feature
<222>  (15)..(19)
<223>  locked nucleic acid

<220>
<221>  misc_feature
<222>  (18)..(18)
<223>  5'methyl

<400>  79
ctctgcacgc tcagcatct                                                    19


<210>  80
<211>  15
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  ASO H24


<220>
<221>  misc_feature
<222>  (1)..(3)
<223>  locked nucleic acid

<220>
<221>  misc_feature
<222>  (2)..(2)
<223>  5'methyl

<220>
<221>  misc_feature
<222>  (4)..(12)
<223>  phosphorothioate bonds

<220>
<221>  misc_feature
<222>  (4)..(4)
<223>  5'methyl

<220>
<221>  misc_feature
<222>  (6)..(6)
<223>  5'methyl

<220>
<221>  misc_feature
<222>  (8)..(8)
<223>  5'methyl

<220>
<221>  misc_feature
<222>  (11)..(11)
<223>  5'methyl

<220>
<221>  misc_feature
<222>  (13)..(15)
<223>  locked nucleic acid

<220>
<221>  misc_feature
<222>  (14)..(14)
<223>  5'methyl

<400>  80
gcacgctcag catct                                                        15


<210>  81
<211>  17
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  ASO H25


<220>
<221>  misc_feature
<222>  (1)..(4)
<223>  locked nucleic acid

<220>
<221>  misc_feature
<222>  (2)..(2)
<223>  5'methyl

<220>
<221>  misc_feature
<222>  (5)..(14)
<223>  phosphorothioate bonds

<220>
<221>  misc_feature
<222>  (5)..(5)
<223>  5'methyl

<220>
<221>  misc_feature
<222>  (7)..(7)
<223>  5'methyl

<220>
<221>  misc_feature
<222>  (9)..(9)
<223>  5'methyl

<220>
<221>  misc_feature
<222>  (14)..(14)
<223>  5'methyl

<220>
<221>  misc_feature
<222>  (15)..(17)
<223>  locked nucleic acid

<220>
<221>  misc_feature
<222>  (17)..(17)
<223>  5'methyl

<400>  81
tctgcacgct cagcatc                                                      17


<210>  82
<211>  16
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  ASO H26


<220>
<221>  misc_feature
<222>  (1)..(3)
<223>  locked nucleic acid

<220>
<221>  misc_feature
<222>  (1)..(3)
<223>  phosphorothioate bonds

<220>
<221>  misc_feature
<222>  (1)..(1)
<223>  5'methyl

<220>
<221>  misc_feature
<222>  (4)..(12)
<223>  phosphorothioate bonds

<220>
<221>  misc_feature
<222>  (4)..(4)
<223>  5'methyl

<220>
<221>  misc_feature
<222>  (6)..(6)
<223>  5'methyl

<220>
<221>  misc_feature
<222>  (8)..(8)
<223>  5'methyl

<220>
<221>  misc_feature
<222>  (10)..(10)
<223>  5'methyl

<220>
<221>  misc_feature
<222>  (13)..(13)
<223>  5'methyl

<220>
<221>  misc_feature
<222>  (13)..(16)
<223>  locked nucleic acid

<220>
<221>  misc_feature
<222>  (16)..(16)
<223>  5'methyl

<400>  82
ctgcacgctc agcatc                                                       16


<210>  83
<211>  15
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  ASO H27


<220>
<221>  misc_feature
<222>  (1)..(3)
<223>  locked nucleic acid

<220>
<221>  misc_feature
<222>  (4)..(12)
<223>  phosphorothioate bonds

<220>
<221>  misc_feature
<222>  (4)..(4)
<223>  5'methyl

<220>
<221>  misc_feature
<222>  (10)..(11)
<223>  5'methyl

<220>
<221>  misc_feature
<222>  (13)..(13)
<223>  5'methyl

<220>
<221>  misc_feature
<222>  (13)..(15)
<223>  locked nucleic acid

<400>  83
ggtcagaagc ctcga                                                        15


<210>  84
<211>  15
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  ASO H28


<220>
<221>  misc_feature
<222>  (1)..(4)
<223>  locked nucleic acid

<220>
<221>  misc_feature
<222>  (4)..(4)
<223>  5'methyl

<220>
<221>  misc_feature
<222>  (5)..(12)
<223>  phosphorothioate bonds

<220>
<221>  misc_feature
<222>  (10)..(11)
<223>  5'methyl

<220>
<221>  misc_feature
<222>  (13)..(13)
<223>  5'methyl

<220>
<221>  misc_feature
<222>  (13)..(15)
<223>  locked nucleic acid

<400>  84
ggtcagaagc ctcga                                                        15


<210>  85
<211>  16
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  ASO H29


<220>
<221>  misc_feature
<222>  (1)..(3)
<223>  locked nucleic acid

<220>
<221>  misc_feature
<222>  (4)..(13)
<223>  phosphorothioate bonds

<220>
<221>  misc_feature
<222>  (4)..(4)
<223>  5'methyl

<220>
<221>  misc_feature
<222>  (8)..(8)
<223>  5'methyl

<220>
<221>  misc_feature
<222>  (14)..(16)
<223>  locked nucleic acid

<400>  85
ggacttgcag gtgtag                                                       16


<210>  86
<211>  17
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  ASO H30


<220>
<221>  misc_feature
<222>  (1)..(4)
<223>  2'-O-(2-Methoxyethyl)-oligori-bonucleotides

<220>
<221>  misc_feature
<222>  (5)..(12)
<223>  phosphorothioate bonds

<220>
<221>  misc_feature
<222>  (5)..(5)
<223>  5'methyl

<220>
<221>  misc_feature
<222>  (9)..(9)
<223>  5'methyl

<220>
<221>  misc_feature
<222>  (14)..(17)
<223>  2'-O-(2-Methoxyethyl)-oligori-bonucleotides

<400>  86
aggacttgca ggtguag                                                      17


<210>  87
<211>  16
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  ASO H31


<220>
<221>  misc_feature
<222>  (1)..(1)
<223>  locked nucleic acid

<220>
<221>  misc_feature
<222>  (2)..(2)
<223>  2'-O-(2-Methoxyethyl)-oligori-bonucleotides

<220>
<221>  misc_feature
<222>  (3)..(3)
<223>  locked nucleic acid

<220>
<221>  misc_feature
<222>  (4)..(4)
<223>  2'-O-(2-Methoxyethyl)-oligori-bonucleotides

<220>
<221>  misc_feature
<222>  (5)..(12)
<223>  phosphorothioate bonds

<220>
<221>  misc_feature
<222>  (5)..(5)
<223>  5'methyl

<220>
<221>  misc_feature
<222>  (9)..(9)
<223>  5'methyl

<220>
<221>  misc_feature
<222>  (13)..(13)
<223>  2'-O-(2-Methoxyethyl)-oligori-bonucleotides

<220>
<221>  misc_feature
<222>  (14)..(14)
<223>  locked nucleic acid

<220>
<221>  misc_feature
<222>  (15)..(15)
<223>  2'-O-(2-Methoxyethyl)-oligori-bonucleotides

<220>
<221>  misc_feature
<222>  (16)..(16)
<223>  locked nucleic acid

<400>  87
aggacttgca ggugua                                                       16


<210>  88
<211>  15
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  ASO H32


<220>
<221>  misc_feature
<222>  (1)..(3)
<223>  2'-O-(2-Methoxyethyl)-oligori-bonucleotides

<220>
<221>  misc_feature
<222>  (4)..(12)
<223>  phosphorothioate bonds

<220>
<221>  misc_feature
<222>  (4)..(4)
<223>  5'methyl

<220>
<221>  misc_feature
<222>  (8)..(8)
<223>  5'methyl

<220>
<221>  misc_feature
<222>  (12)..(12)
<223>  5'methyl

<220>
<221>  misc_feature
<222>  (13)..(15)
<223>  2'-O-(2-Methoxyethyl)-oligori-bonucleotides

<400>  88
ggacttgcag gtgua                                                        15


<210>  89
<211>  15
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  ASO H33


<220>
<221>  misc_feature
<222>  (1)..(3)
<223>  2'-O-(2-Methoxyethyl)-oligori-bonucleotides

<220>
<221>  misc_feature
<222>  (4)..(12)
<223>  phosphorothioate bonds

<220>
<221>  misc_feature
<222>  (5)..(5)
<223>  5'methyl

<220>
<221>  misc_feature
<222>  (9)..(9)
<223>  5'methyl

<220>
<221>  misc_feature
<222>  (13)..(15)
<223>  2'-O-(2-Methoxyethyl)-oligori-bonucleotides

<400>  89
aggacttgca ggugu                                                        15


<210>  90
<211>  16
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  ASO H34


<220>
<221>  misc_feature
<222>  (1)..(3)
<223>  locked nucleic acid

<220>
<221>  misc_feature
<222>  (4)..(13)
<223>  phosphorothioate bonds

<220>
<221>  misc_feature
<222>  (4)..(4)
<223>  5'methyl

<220>
<221>  misc_feature
<222>  (10)..(10)
<223>  5'methyl

<220>
<221>  misc_feature
<222>  (12)..(12)
<223>  5'methyl

<220>
<221>  misc_feature
<222>  (14)..(16)
<223>  locked nucleic acid

<400>  90
gaactgcagc tcggag                                                       16


<210>  91
<211>  15
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  ASO H35


<220>
<221>  misc_feature
<222>  (1)..(3)
<223>  locked nucleic acid

<220>
<221>  misc_feature
<222>  (4)..(12)
<223>  phosphorothioate bonds

<220>
<221>  misc_feature
<222>  (4)..(4)
<223>  5'methyl

<220>
<221>  misc_feature
<222>  (7)..(7)
<223>  5'methyl

<220>
<221>  misc_feature
<222>  (10)..(10)
<223>  5'methyl

<220>
<221>  misc_feature
<222>  (12)..(12)
<223>  5'methyl

<220>
<221>  misc_feature
<222>  (14)..(16)
<223>  locked nucleic acid

<400>  91
gaactgcagc tcgga                                                        15


<210>  92
<211>  15
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  ASO H36


<220>
<221>  misc_feature
<222>  (1)..(3)
<223>  locked nucleic acid

<220>
<221>  misc_feature
<222>  (4)..(12)
<223>  phosphorothioate bonds

<220>
<221>  misc_feature
<222>  (12)..(12)
<223>  5'methyl

<220>
<221>  misc_feature
<222>  (13)..(15)
<223>  locked nucleic acid

<220>
<221>  misc_feature
<222>  (15)..(15)
<223>  5'methyl

<400>  92
aaggtgaact gcagc                                                        15


<210>  93
<211>  20
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  ASO 1477-1


<220>
<221>  misc_feature
<222>  (1)..(5)
<223>  2'-O-(2-Methoxyethyl)-oligori-bonucleotides

<220>
<221>  misc_feature
<222>  (2)..(2)
<223>  5'methyl

<220>
<221>  misc_feature
<222>  (4)..(4)
<223>  5'methyl

<220>
<221>  misc_feature
<222>  (6)..(15)
<223>  phosphorothioate bonds

<220>
<221>  misc_feature
<222>  (7)..(7)
<223>  5'methyl

<220>
<221>  misc_feature
<222>  (14)..(14)
<223>  5'methyl

<220>
<221>  misc_feature
<222>  (16)..(20)
<223>  2'-O-(2-Methoxyethyl)-oligori-bonucleotides

<220>
<221>  misc_feature
<222>  (20)..(20)
<223>  5'methyl

<400>  93
gcgcatcaaa ggtcagaagc                                                   20


<210>  94
<211>  20
<212>  DNA
<213>  Artificial Sequence

<220>
<223>   ASO 1659-2


<220>
<221>  misc_feature
<222>  (1)..(5)
<223>  2'-O-(2-Methoxyethyl)-oligori-bonucleotides

<220>
<221>  misc_feature
<222>  (1)..(2)
<223>  5'Methyl

<220>
<221>  misc_feature
<222>  (6)..(15)
<223>  phosphorothioate bonds

<220>
<221>  misc_feature
<222>  (12)..(12)
<223>  5'Methyl

<220>
<221>  misc_feature
<222>  (16)..(20)
<223>  2'-O-(2-Methoxyethyl)-oligori-bonucleotides

<400>  94
ccugggaatg tcaagguugg                                                   20


<210>  95
<211>  17
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  ASO 6-1


<220>
<221>  misc_feature
<222>  (1)..(16)
<223>  phosphorothioate bonds

<220>
<221>  misc_feature
<222>  (1)..(4)
<223>  2'-O-(2-Methoxyethyl)-oligori-bonucleotides

<220>
<221>  misc_feature
<222>  (2)..(2)
<223>  5'methyl

<220>
<221>  misc_feature
<222>  (4)..(4)
<223>  5'methyl

<220>
<221>  misc_feature
<222>  (7)..(7)
<223>  5'methyl

<220>
<221>  misc_feature
<222>  (10)..(11)
<223>  5'methyl

<220>
<221>  misc_feature
<222>  (13)..(14)
<223>  5'methyl

<220>
<221>  misc_feature
<222>  (14)..(17)
<223>  2'-O-(2-Methoxyethyl)-oligori-bonucleotides

<220>
<221>  misc_feature
<222>  (17)..(17)
<223>  5'methyl

<400>  95
gcucgtctac ctccuuc                                                      17


<210>  96
<211>  17
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  ASO 6-2


<220>
<221>  misc_feature
<222>  (1)..(2)
<223>  phosphorothioate bonds

<220>
<221>  misc_feature
<222>  (1)..(4)
<223>  2'-O-(2-Methoxyethyl)-oligori-bonucleotides

<220>
<221>  misc_feature
<222>  (2)..(2)
<223>  5'methyl

<220>
<221>  misc_feature
<222>  (4)..(14)
<223>  phosphorothioate bonds

<220>
<221>  misc_feature
<222>  (4)..(4)
<223>  5'methyl

<220>
<221>  misc_feature
<222>  (7)..(7)
<223>  5'methyl

<220>
<221>  misc_feature
<222>  (10)..(11)
<223>  5'methyl

<220>
<221>  misc_feature
<222>  (13)..(14)
<223>  5'methyl

<220>
<221>  misc_feature
<222>  (14)..(17)
<223>  2'-O-(2-Methoxyethyl)-oligori-bonucleotides

<220>
<221>  misc_feature
<222>  (16)..(17)
<223>  phosphorothioate bonds

<220>
<221>  misc_feature
<222>  (17)..(17)
<223>  5'methyl

<400>  96
gcucgtctac ctccuuc                                                      17


<210>  97
<211>  19
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  ASO 6-3


<220>
<221>  misc_feature
<222>  (1)..(18)
<223>  phosphorothioate bonds

<220>
<221>  misc_feature
<222>  (1)..(5)
<223>  2'-O-(2-Methoxyethyl)-oligori-bonucleotides

<220>
<221>  misc_feature
<222>  (3)..(3)
<223>  5'methyl

<220>
<221>  misc_feature
<222>  (5)..(5)
<223>  5'methyl

<220>
<221>  misc_feature
<222>  (8)..(8)
<223>  5'methyl

<220>
<221>  misc_feature
<222>  (11)..(12)
<223>  5'methyl

<220>
<221>  misc_feature
<222>  (14)..(15)
<223>  5'methyl

<220>
<221>  misc_feature
<222>  (15)..(19)
<223>  2'-O-(2-Methoxyethyl)-oligori-bonucleotides

<220>
<221>  misc_feature
<222>  (18)..(18)
<223>  5'methyl

<400>  97
ugcucgtcta cctccuuca                                                    19


<210>  98
<211>  19
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  ASO 6-4


<220>
<221>  misc_feature
<222>  (1)..(2)
<223>  phosphorothioate bonds

<220>
<221>  misc_feature
<222>  (1)..(5)
<223>  2'-O-(2-Methoxyethyl)-oligori-bonucleotides

<220>
<221>  misc_feature
<222>  (3)..(3)
<223>  5'methyl

<220>
<221>  misc_feature
<222>  (5)..(15)
<223>  phosphorothioate bonds

<220>
<221>  misc_feature
<222>  (5)..(5)
<223>  5'methyl

<220>
<221>  misc_feature
<222>  (8)..(8)
<223>  5'methyl

<220>
<221>  misc_feature
<222>  (11)..(12)
<223>  5'methyl

<220>
<221>  misc_feature
<222>  (14)..(15)
<223>  5'methyl

<220>
<221>  misc_feature
<222>  (15)..(19)
<223>  2'-O-(2-Methoxyethyl)-oligori-bonucleotides

<220>
<221>  misc_feature
<222>  (18)..(19)
<223>  phosphorothioate bonds

<220>
<221>  misc_feature
<222>  (18)..(18)
<223>  5'methyl

<400>  98
ugcucgtcta cctccuuca                                                    19


<210>  99
<211>  17
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  ASO 6-5


<220>
<221>  misc_feature
<222>  (1)..(4)
<223>  2'-O-(2-Methoxyethyl)-oligori-bonucleotides

<220>
<221>  misc_feature
<222>  (2)..(2)
<223>  5'methyl

<220>
<221>  misc_feature
<222>  (4)..(14)
<223>  phosphorothioate bonds

<220>
<221>  misc_feature
<222>  (4)..(4)
<223>  5'methyl

<220>
<221>  misc_feature
<222>  (7)..(7)
<223>  5'methyl

<220>
<221>  misc_feature
<222>  (10)..(11)
<223>  5'methyl

<220>
<221>  misc_feature
<222>  (13)..(14)
<223>  5'methyl

<220>
<221>  misc_feature
<222>  (14)..(17)
<223>  2'-O-(2-Methoxyethyl)-oligori-bonucleotides

<220>
<221>  misc_feature
<222>  (17)..(17)
<223>  5'methyl

<400>  99
gcucgtctac ctccuuc                                                      17


<210>  100
<211>  16
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  ASO 7-1


<220>
<221>  misc_feature
<222>  (1)..(16)
<223>  phosphorothioate bonds

<220>
<221>  misc_feature
<222>  (1)..(3)
<223>  2'-O-(2-Methoxyethyl)-oligori-bonucleotides

<220>
<221>  misc_feature
<222>  (2)..(2)
<223>  5'methyl

<220>
<221>  misc_feature
<222>  (4)..(4)
<223>  5'methyl

<220>
<221>  misc_feature
<222>  (7)..(7)
<223>  5'methyl

<220>
<221>  misc_feature
<222>  (10)..(11)
<223>  5'methyl

<220>
<221>  misc_feature
<222>  (13)..(14)
<223>  5'methyl

<220>
<221>  misc_feature
<222>  (14)..(16)
<223>  2'-O-(2-Methoxyethyl)-oligori-bonucleotides

<400>  100
gcucgtctac ctccuu                                                       16


<210>  101
<211>  16
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  ASO 7-2


<220>
<221>  misc_feature
<222>  (1)..(16)
<223>  phosphorothioate bonds

<220>
<221>  misc_feature
<222>  (1)..(1)
<223>  2'-O-(2-Methoxyethyl)-oligori-bonucleotides

<220>
<221>  misc_feature
<222>  (2)..(2)
<223>  5'methyl

<220>
<221>  misc_feature
<222>  (2)..(2)
<223>  locked nucleic acid

<220>
<221>  misc_feature
<222>  (3)..(3)
<223>  2'-O-(2-Methoxyethyl)-oligori-bonucleotides

<220>
<221>  misc_feature
<222>  (4)..(4)
<223>  5'methyl

<220>
<221>  misc_feature
<222>  (7)..(7)
<223>  5'methyl

<220>
<221>  misc_feature
<222>  (10)..(11)
<223>  5'methyl

<220>
<221>  misc_feature
<222>  (13)..(14)
<223>  5'methyl

<220>
<221>  misc_feature
<222>  (14)..(14)
<223>  2'-O-(2-Methoxyethyl)-oligori-bonucleotides

<220>
<221>  misc_feature
<222>  (15)..(15)
<223>  locked nucleic acid

<220>
<221>  misc_feature
<222>  (16)..(16)
<223>  2'-O-(2-Methoxyethyl)-oligori-bonucleotides

<400>  101
gcucgtctac ctccuu                                                       16


<210>  102
<211>  18
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  ASO 7-3


<220>
<221>  misc_feature
<222>  (1)..(18)
<223>  phosphorothioate bonds

<220>
<221>  misc_feature
<222>  (1)..(4)
<223>  2'-O-(2-Methoxyethyl)-oligori-bonucleotides

<220>
<221>  misc_feature
<222>  (3)..(3)
<223>  5'methyl

<220>
<221>  misc_feature
<222>  (5)..(5)
<223>  5'methyl

<220>
<221>  misc_feature
<222>  (8)..(8)
<223>  5'methyl

<220>
<221>  misc_feature
<222>  (11)..(12)
<223>  5'methyl

<220>
<221>  misc_feature
<222>  (14)..(15)
<223>  5'methyl

<220>
<221>  misc_feature
<222>  (15)..(18)
<223>  2'-O-(2-Methoxyethyl)-oligori-bonucleotides

<220>
<221>  misc_feature
<222>  (18)..(18)
<223>  5'methyl

<400>  102
ugcucgtcta cctccuuc                                                     18


<210>  103
<211>  18
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  ASO 7-4


<220>
<221>  misc_feature
<222>  (1)..(2)
<223>  phosphorothioate bonds

<220>
<221>  misc_feature
<222>  (1)..(4)
<223>  2'-O-(2-Methoxyethyl)-oligori-bonucleotides

<220>
<221>  misc_feature
<222>  (3)..(3)
<223>  5'methyl

<220>
<221>  misc_feature
<222>  (4)..(15)
<223>  phosphorothioate bonds

<220>
<221>  misc_feature
<222>  (5)..(5)
<223>  5'methyl

<220>
<221>  misc_feature
<222>  (8)..(8)
<223>  5'methyl

<220>
<221>  misc_feature
<222>  (11)..(12)
<223>  5'methyl

<220>
<221>  misc_feature
<222>  (14)..(15)
<223>  5'methyl

<220>
<221>  misc_feature
<222>  (15)..(18)
<223>  2'-O-(2-Methoxyethyl)-oligori-bonucleotides

<220>
<221>  misc_feature
<222>  (18)..(19)
<223>  phosphorothioate bonds

<220>
<221>  misc_feature
<222>  (18)..(18)
<223>  5'methyl

<400>  103
ugcucgtcta cctccuuc                                                     18


<210>  104
<211>  16
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  ASO 7-5


<220>
<221>  misc_feature
<222>  (1)..(3)
<223>  2'-O-(2-Methoxyethyl)-oligori-bonucleotides

<220>
<221>  misc_feature
<222>  (2)..(2)
<223>  5'methyl

<220>
<221>  misc_feature
<222>  (4)..(14)
<223>  phosphorothioate bonds

<220>
<221>  misc_feature
<222>  (4)..(4)
<223>  5'methyl

<220>
<221>  misc_feature
<222>  (7)..(7)
<223>  5'methyl

<220>
<221>  misc_feature
<222>  (10)..(11)
<223>  5'methyl

<220>
<221>  misc_feature
<222>  (13)..(14)
<223>  5'methyl

<220>
<221>  misc_feature
<222>  (14)..(16)
<223>  2'-O-(2-Methoxyethyl)-oligori-bonucleotides

<400>  104
gcucgtctac ctccuu                                                       16


<210>  105
<211>  18
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  ASO 7-6


<220>
<221>  misc_feature
<222>  (1)..(4)
<223>  2'-O-(2-Methoxyethyl)-oligori-bonucleotides

<220>
<221>  misc_feature
<222>  (3)..(3)
<223>  5'methyl

<220>
<221>  misc_feature
<222>  (5)..(15)
<223>  phosphorothioate bonds

<220>
<221>  misc_feature
<222>  (5)..(5)
<223>  5'methyl

<220>
<221>  misc_feature
<222>  (8)..(8)
<223>  5'methyl

<220>
<221>  misc_feature
<222>  (11)..(12)
<223>  5'methyl

<220>
<221>  misc_feature
<222>  (14)..(15)
<223>  5'methyl

<220>
<221>  misc_feature
<222>  (15)..(18)
<223>  2'-O-(2-Methoxyethyl)-oligori-bonucleotides

<220>
<221>  misc_feature
<222>  (18)..(18)
<223>  5'methyl

<400>  105
ugcucgtcta cctccuuc                                                     18


<210>  106
<211>  16
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  ASO 8-1


<220>
<221>  misc_feature
<222>  (1)..(16)
<223>  phosphorothioate bonds

<220>
<221>  misc_feature
<222>  (1)..(3)
<223>  2'-O-(2-Methoxyethyl)-oligori-bonucleotides

<220>
<221>  misc_feature
<222>  (3)..(3)
<223>  5'methyl

<220>
<221>  misc_feature
<222>  (5)..(5)
<223>  5'methyl

<220>
<221>  misc_feature
<222>  (8)..(8)
<223>  5'methyl

<220>
<221>  misc_feature
<222>  (11)..(12)
<223>  5'methyl

<220>
<221>  misc_feature
<222>  (14)..(15)
<223>  5'methyl

<220>
<221>  misc_feature
<222>  (14)..(16)
<223>  2'-O-(2-Methoxyethyl)-oligori-bonucleotides

<400>  106
ugctcgtcta cctccu                                                       16


<210>  107
<211>  16
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  ASO 8-2


<220>
<221>  misc_feature
<222>  (1)..(2)
<223>  phosphorothioate bonds

<220>
<221>  misc_feature
<222>  (1)..(1)
<223>  2'-O-(2-Methoxyethyl)-oligori-bonucleotides

<220>
<221>  misc_feature
<222>  (2)..(2)
<223>  locked nucleic acid

<220>
<221>  misc_feature
<222>  (3)..(3)
<223>  5'methyl

<220>
<221>  misc_feature
<222>  (3)..(14)
<223>  phosphorothioate bonds

<220>
<221>  misc_feature
<222>  (3)..(3)
<223>  2'-O-(2-Methoxyethyl)-oligori-bonucleotides

<220>
<221>  misc_feature
<222>  (5)..(5)
<223>  5'methyl

<220>
<221>  misc_feature
<222>  (8)..(8)
<223>  5'methyl

<220>
<221>  misc_feature
<222>  (11)..(12)
<223>  5'methyl

<220>
<221>  misc_feature
<222>  (14)..(15)
<223>  5'methyl

<220>
<221>  misc_feature
<222>  (14)..(14)
<223>  2'-O-(2-Methoxyethyl)-oligori-bonucleotides

<220>
<221>  misc_feature
<222>  (15)..(16)
<223>  phosphorothioate bonds

<220>
<221>  misc_feature
<222>  (15)..(15)
<223>  locked nucleic acid

<220>
<221>  misc_feature
<222>  (16)..(16)
<223>  2'-O-(2-Methoxyethyl)-oligori-bonucleotides

<400>  107
ugctcgtcta cctccu                                                       16


<210>  108
<211>  20
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  ASO 8-3


<220>
<221>  misc_feature
<222>  (1)..(20)
<223>  phosphorothioate bonds

<220>
<221>  misc_feature
<222>  (1)..(5)
<223>  2'-O-(2-Methoxyethyl)-oligori-bonucleotides

<220>
<221>  misc_feature
<222>  (2)..(2)
<223>  5'methyl

<220>
<221>  misc_feature
<222>  (5)..(5)
<223>  5'methyl

<220>
<221>  misc_feature
<222>  (7)..(7)
<223>  5'methyl

<220>
<221>  misc_feature
<222>  (10)..(10)
<223>  5'methyl

<220>
<221>  misc_feature
<222>  (13)..(14)
<223>  5'methyl

<220>
<221>  misc_feature
<222>  (16)..(17)
<223>  5'methyl

<220>
<221>  misc_feature
<222>  (16)..(20)
<223>  2'-O-(2-Methoxyethyl)-oligori-bonucleotides

<220>
<221>  misc_feature
<222>  (20)..(20)
<223>  5'methyl

<400>  108
ucugctcgtc tacctccuuc                                                   20


<210>  109
<211>  20
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  ASO 8-4


<220>
<221>  misc_feature
<222>  (1)..(2)
<223>  phosphorothioate bonds

<220>
<221>  misc_feature
<222>  (1)..(5)
<223>  2'-O-(2-Methoxyethyl)-oligori-bonucleotides

<220>
<221>  misc_feature
<222>  (2)..(2)
<223>  5'methyl

<220>
<221>  misc_feature
<222>  (5)..(16)
<223>  phosphorothioate bonds

<220>
<221>  misc_feature
<222>  (5)..(5)
<223>  5'methyl

<220>
<221>  misc_feature
<222>  (7)..(7)
<223>  5'methyl

<220>
<221>  misc_feature
<222>  (10)..(10)
<223>  5'methyl

<220>
<221>  misc_feature
<222>  (13)..(14)
<223>  5'methyl

<220>
<221>  misc_feature
<222>  (16)..(17)
<223>  5'methyl

<220>
<221>  misc_feature
<222>  (16)..(20)
<223>  2'-O-(2-Methoxyethyl)-oligori-bonucleotides

<220>
<221>  misc_feature
<222>  (19)..(20)
<223>  phosphorothioate bonds

<220>
<221>  misc_feature
<222>  (20)..(20)
<223>  5'methyl

<400>  109
ucugctcgtc tacctccuuc                                                   20


<210>  110
<211>  16
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  ASO 8-5


<220>
<221>  misc_feature
<222>  (1)..(3)
<223>  2'-O-(2-Methoxyethyl)-oligori-bonucleotides

<220>
<221>  misc_feature
<222>  (3)..(3)
<223>  5'methyl

<220>
<221>  misc_feature
<222>  (4)..(14)
<223>  phosphorothioate bonds

<220>
<221>  misc_feature
<222>  (5)..(5)
<223>  5'methyl

<220>
<221>  misc_feature
<222>  (8)..(8)
<223>  5'methyl

<220>
<221>  misc_feature
<222>  (11)..(12)
<223>  5'methyl

<220>
<221>  misc_feature
<222>  (14)..(15)
<223>  5'methyl

<220>
<221>  misc_feature
<222>  (14)..(16)
<223>  2'-O-(2-Methoxyethyl)-oligori-bonucleotides

<400>  110
ugctcgtcta cctccu                                                       16


<210>  111
<211>  15
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  ASO 18-1


<220>
<221>  misc_feature
<222>  (1)..(15)
<223>  phosphorothioate bonds

<220>
<221>  misc_feature
<222>  (1)..(3)
<223>  2'-O-(2-Methoxyethyl)-oligori-bonucleotides

<220>
<221>  misc_feature
<222>  (3)..(3)
<223>  5'methyl

<220>
<221>  misc_feature
<222>  (5)..(5)
<223>  5'methyl

<220>
<221>  misc_feature
<222>  (8)..(8)
<223>  5'methyl

<220>
<221>  misc_feature
<222>  (11)..(12)
<223>  5'methyl

<220>
<221>  misc_feature
<222>  (13)..(15)
<223>  2'-O-(2-Methoxyethyl)-oligori-bonucleotides

<220>
<221>  misc_feature
<222>  (14)..(15)
<223>  5'methyl

<400>  111
ugctcgtcta ccucc                                                        15


<210>  112
<211>  15
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  ASO 18-2


<220>
<221>  misc_feature
<222>  (1)..(15)
<223>  phosphorothioate bonds

<220>
<221>  misc_feature
<222>  (1)..(3)
<223>  locked nucleic acid

<220>
<221>  misc_feature
<222>  (3)..(3)
<223>  5'methyl

<220>
<221>  misc_feature
<222>  (5)..(5)
<223>  5'methyl

<220>
<221>  misc_feature
<222>  (8)..(8)
<223>  5'methyl

<220>
<221>  misc_feature
<222>  (11)..(12)
<223>  5'methyl

<220>
<221>  misc_feature
<222>  (13)..(15)
<223>  locked nucleic acid

<220>
<221>  misc_feature
<222>  (14)..(15)
<223>  5'methyl

<400>  112
ugctcgtcta ccucc                                                        15


<210>  113
<211>  17
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  ASO 18-3


<220>
<221>  misc_feature
<222>  (1)..(1)
<223>  5'methyl

<220>
<221>  misc_feature
<222>  (1)..(17)
<223>  phosphorothioate bonds

<220>
<221>  misc_feature
<222>  (1)..(4)
<223>  2'-O-(2-Methoxyethyl)-oligori-bonucleotides

<220>
<221>  misc_feature
<222>  (4)..(4)
<223>  5'methyl

<220>
<221>  misc_feature
<222>  (6)..(6)
<223>  5'methyl

<220>
<221>  misc_feature
<222>  (9)..(9)
<223>  5'methyl

<220>
<221>  misc_feature
<222>  (12)..(13)
<223>  5'methyl

<220>
<221>  misc_feature
<222>  (14)..(17)
<223>  2'-O-(2-Methoxyethyl)-oligori-bonucleotides

<220>
<221>  misc_feature
<222>  (15)..(16)
<223>  5'methyl

<400>  113
cugctcgtct accuccu                                                      17


<210>  114
<211>  15
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  ASO 18-5


<220>
<221>  misc_feature
<222>  (1)..(3)
<223>  2'-O-(2-Methoxyethyl)-oligori-bonucleotides

<220>
<221>  misc_feature
<222>  (3)..(3)
<223>  5'methyl

<220>
<221>  misc_feature
<222>  (4)..(13)
<223>  phosphorothioate bonds

<220>
<221>  misc_feature
<222>  (5)..(5)
<223>  5'methyl

<220>
<221>  misc_feature
<222>  (8)..(8)
<223>  5'methyl

<220>
<221>  misc_feature
<222>  (11)..(12)
<223>  5'methyl

<220>
<221>  misc_feature
<222>  (13)..(15)
<223>  2'-O-(2-Methoxyethyl)-oligori-bonucleotides

<220>
<221>  misc_feature
<222>  (14)..(15)
<223>  5'methyl

<400>  114
ugctcgtcta ccucc                                                        15


