
                                SEQUENCE LISTING

<110> Genentech, Inc.

<120> OPTIMIZED TLR7 LIGANDS AND USES THEREOF

<130> 14639-20532.40

<140> Not Yet Assigned
<141> Concurrently Herewith

<150> US 63/176,128
<151> 2021-04-16

<160> 72

<170> FastSEQ for Windows Version 4.0

<210> 1
<211> 16
<212> RNA
<213> Artificial Sequence

<220> 
<223> Synthetic Construct

<220> 
<221> VARIANT        
<222> (1)..(16)
<223> Linkages between each nucleoside as shown in Table 8 of the
      specification. Nucleosides modified as shown in Table 8 of
      the specification.

<400> 1
ccgagccgcu uuuccc                                                 16

<210> 2
<211> 21
<212> RNA
<213> Artificial Sequence

<220> 
<223> Synthetic Construct

<220> 
<221> VARIANT        
<222> (1)..(21)
<223> Linkages between each nucleoside as shown in Table 8 of the
      specification. Nucleosides modified as shown in Table 8 of
      the specification.

<400> 2
cggcucggca gaagccgggc c                                           21

<210> 3
<211> 20
<212> RNA
<213> Artificial Sequence

<220> 
<223> Synthetic Construct

<220> 
<221> VARIANT        
<222> (1)..(20)
<223> Linkages between each nucleoside as shown in Table 8 of the
      specification. Nucleosides modified as shown in Table 8 of
      the specification.

<400> 3
ucucucucuc ucucucucuc                                             20

<210> 4
<211> 20
<212> RNA
<213> Artificial Sequence

<220> 
<223> Synthetic Construct

<220> 
<221> VARIANT        
<222> (1)..(20)
<223> Linkages between each nucleoside as shown in Table 8 of the
      specification. Nucleosides modified as shown in Table 8 of
      the specification.

<400> 4
ccuucuucuu cuucuucuuc                                             20

<210> 5
<211> 18
<212> RNA
<213> Artificial Sequence

<220> 
<223> Synthetic Construct

<220> 
<221> VARIANT        
<222> (1)..(18)
<223> Linkages between each nucleoside as shown in Table 8 of the
      specification. Nucleosides modified as shown in Table 8 of
      the specification.

<400> 5
cagaccuucc agaccuuc                                               18

<210> 6
<211> 3
<212> RNA
<213> Artificial Sequence

<220> 
<223> Synthetic Construct

<220> 
<221> VARIANT        
<222> (1)..(3)
<223> Linkages between each nucleoside as shown in Table 8 of the
      specification. Nucleosides modified as shown in Table 8 of
      the specification.

<220> 
<221> misc_feature   
<222> 1, 3
<223> n = any nucleoside

<400> 6
nun                                                               3

<210> 7
<211> 6
<212> RNA
<213> Artificial Sequence

<220> 
<223> Synthetic Construct

<220> 
<221> VARIANT        
<222> (1)..(6)
<223> Linkages between each nucleoside as shown in Table 8 of the
      specification. Nucleosides modified as shown in Table 8 of
      the specification.

<400> 7
cuuuuc                                                            6

<210> 8
<211> 3
<212> RNA
<213> Artificial Sequence

<220> 
<223> Synthetic Construct

<220> 
<221> VARIANT        
<222> (1)..(3)
<223> Linkages between each nucleoside as shown in Table 8 of the
      specification. Nucleosides modified as shown in Table 8 of
      the specification.

<400> 8
cuu                                                               3

<210> 9
<211> 3
<212> RNA
<213> Artificial Sequence

<220> 
<223> Synthetic Construct

<220> 
<221> VARIANT        
<222> (1)..(3)
<223> Linkages between each nucleoside as shown in Table 8 of the
      specification. Nucleosides modified as shown in Table 8 of
      the specification.

<400> 9
uuu                                                               3

<210> 10
<211> 3
<212> RNA
<213> Artificial Sequence

<220> 
<223> Synthetic Construct

<220> 
<221> VARIANT        
<222> (1)..(3)
<223> Linkages between each nucleoside as shown in Table 8 of the
      specification. Nucleosides modified as shown in Table 8 of
      the specification.

<400> 10
uuc                                                               3

<210> 11
<211> 6
<212> RNA
<213> Artificial Sequence

<220> 
<223> Synthetic Construct

<220> 
<221> VARIANT        
<222> (1)..(6)
<223> Linkages between each nucleoside as shown in Table 8 of the
      specification. Nucleosides modified as shown in Table 8 of
      the specification.

<220> 
<221> misc_feature   
<222> 2, 4
<223> n = 2'-Fluoro-U or 2'O-methyl-U

<400> 11
cnunuc                                                            6

<210> 12
<211> 16
<212> RNA
<213> Artificial Sequence

<220> 
<223> Synthetic Construct

<220> 
<221> VARIANT        
<222> (1)..(16)
<223> Linkages between each nucleoside as shown in Table 8 of the
      specification. Nucleosides modified as shown in Table 8 of
      the specification.

<400> 12
ccgagccgcu uuuccc                                                 16

<210> 13
<211> 16
<212> RNA
<213> Artificial Sequence

<220> 
<223> Synthetic Construct

<220> 
<221> VARIANT        
<222> (1)..(16)
<223> Linkages between each nucleoside as shown in Table 8 of the
      specification. Nucleosides modified as shown in Table 8 of
      the specification.

<400> 13
ccgagccgcu uuuccc                                                 16

<210> 14
<211> 16
<212> RNA
<213> Artificial Sequence

<220> 
<223> Synthetic Construct

<220> 
<221> VARIANT        
<222> (1)..(16)
<223> Linkages between each nucleoside as shown in Table 8 of the
      specification. Nucleosides modified as shown in Table 8 of
      the specification.

<400> 14
ccgagccgcu uuuccc                                                 16

<210> 15
<211> 16
<212> RNA
<213> Artificial Sequence

<220> 
<223> Synthetic Construct

<220> 
<221> VARIANT        
<222> (1)..(16)
<223> Linkages between each nucleoside as shown in Table 8 of the
      specification. Nucleosides modified as shown in Table 8 of
      the specification.

<400> 15
ccgagccgcu uuuccc                                                 16

<210> 16
<211> 16
<212> RNA
<213> Artificial Sequence

<220> 
<223> Synthetic Construct

<220> 
<221> VARIANT        
<222> (1)..(16)
<223> Linkages between each nucleoside as shown in Table 8 of the
      specification. Nucleosides modified as shown in Table 8 of
      the specification.

<400> 16
ccgagccgcu uuuccc                                                 16

<210> 17
<211> 16
<212> RNA
<213> Artificial Sequence

<220> 
<223> Synthetic Construct

<220> 
<221> VARIANT        
<222> (1)..(16)
<223> Linkages between each nucleoside as shown in Table 8 of the
      specification. Nucleosides modified as shown in Table 8 of
      the specification.

<400> 17
ccgagccgcu uuuccc                                                 16

<210> 18
<211> 16
<212> RNA
<213> Artificial Sequence

<220> 
<223> Synthetic Construct

<220> 
<221> VARIANT        
<222> (1)..(16)
<223> Linkages between each nucleoside as shown in Table 8 of the
      specification. Nucleosides modified as shown in Table 8 of
      the specification.

<400> 18
ccgagccgcu uuuccc                                                 16

<210> 19
<211> 16
<212> RNA
<213> Artificial Sequence

<220> 
<223> Synthetic Construct

<220> 
<221> VARIANT        
<222> (1)..(16)
<223> Linkages between each nucleoside as shown in Table 8 of the
      specification. Nucleosides modified as shown in Table 8 of
      the specification.

<400> 19
ccgagccgcu uuuccc                                                 16

<210> 20
<211> 16
<212> RNA
<213> Artificial Sequence

<220> 
<223> Synthetic Construct

<220> 
<221> VARIANT        
<222> (1)..(16)
<223> Linkages between each nucleoside as shown in Table 8 of the
      specification. Nucleosides modified as shown in Table 8 of
      the specification.

<400> 20
ccgagccgcu uuuccc                                                 16

<210> 21
<211> 3
<212> RNA
<213> Artificial Sequence

<220> 
<223> Synthetic Construct

<220> 
<221> VARIANT        
<222> (1)..(3)
<223> Linkages between each nucleoside as shown in Table 8 of the
      specification. Nucleosides modified as shown in Table 8 of
      the specification.

<400> 21
cuc                                                               3

<210> 22
<211> 3
<212> RNA
<213> Artificial Sequence

<220> 
<223> Synthetic Construct

<220> 
<221> VARIANT        
<222> (1)..(3)
<223> Linkages between each nucleoside as shown in Table 8 of the
      specification. Nucleosides modified as shown in Table 8 of
      the specification.

<220> 
<221> misc_feature   
<222> 1
<223> n = 2'-Fluoro-C or 2'O-methyl-C

<400> 22
nuc                                                               3

<210> 23
<211> 21
<212> RNA
<213> Artificial Sequence

<220> 
<223> Synthetic Construct

<220> 
<221> VARIANT        
<222> (1)..(21)
<223> Linkages between each nucleoside as shown in Table 8 of the
      specification. Nucleosides modified as shown in Table 8 of
      the specification.

<400> 23
cggcucggca gaagccgggc c                                           21

<210> 24
<211> 21
<212> RNA
<213> Artificial Sequence

<220> 
<223> Synthetic Construct

<220> 
<221> VARIANT        
<222> (1)..(21)
<223> Linkages between each nucleoside as shown in Table 8 of the
      specification. Nucleosides modified as shown in Table 8 of
      the specification.

<400> 24
cggcucggca gaagccgggc c                                           21

<210> 25
<211> 21
<212> RNA
<213> Artificial Sequence

<220> 
<223> Synthetic Construct

<220> 
<221> VARIANT        
<222> (1)..(21)
<223> Linkages between each nucleoside as shown in Table 8 of the
      specification. Nucleosides modified as shown in Table 8 of
      the specification.

<400> 25
cggcucggca gaagccgggc c                                           21

<210> 26
<211> 20
<212> RNA
<213> Artificial Sequence

<220> 
<223> Synthetic Construct

<220> 
<221> VARIANT        
<222> (1)..(20)
<223> Linkages between each nucleoside as shown in Table 8 of the
      specification. Nucleosides modified as shown in Table 8 of
      the specification.

<400> 26
ucucucucuc ucucucucuc                                             20

<210> 27
<211> 20
<212> RNA
<213> Artificial Sequence

<220> 
<223> Synthetic Construct

<220> 
<221> VARIANT        
<222> (1)..(20)
<223> Linkages between each nucleoside as shown in Table 8 of the
      specification. Nucleosides modified as shown in Table 8 of
      the specification.

<400> 27
ucucucucuc ucucucucuc                                             20

<210> 28
<211> 20
<212> RNA
<213> Artificial Sequence

<220> 
<223> Synthetic Construct

<220> 
<221> VARIANT        
<222> (1)..(20)
<223> Linkages between each nucleoside as shown in Table 8 of the
      specification. Nucleosides modified as shown in Table 8 of
      the specification.

<400> 28
ucucucucuc ucucucucuc                                             20

<210> 29
<211> 20
<212> RNA
<213> Artificial Sequence

<220> 
<223> Synthetic Construct

<220> 
<221> VARIANT        
<222> (1)..(20)
<223> Linkages between each nucleoside as shown in Table 8 of the
      specification. Nucleosides modified as shown in Table 8 of
      the specification.

<400> 29
ccuucuucuu cuucuucuuc                                             20

<210> 30
<211> 20
<212> RNA
<213> Artificial Sequence

<220> 
<223> Synthetic Construct

<220> 
<221> VARIANT        
<222> (1)..(20)
<223> Linkages between each nucleoside as shown in Table 8 of the
      specification. Nucleosides modified as shown in Table 8 of
      the specification.

<400> 30
ccuucuucuu cuucuucuuc                                             20

<210> 31
<211> 20
<212> RNA
<213> Artificial Sequence

<220> 
<223> Synthetic Construct

<220> 
<221> VARIANT        
<222> (1)..(20)
<223> Linkages between each nucleoside as shown in Table 8 of the
      specification. Nucleosides modified as shown in Table 8 of
      the specification.

<400> 31
ccuucuucuu cuucuucuuc                                             20

<210> 32
<211> 4
<212> RNA
<213> Artificial Sequence

<220> 
<223> Synthetic Construct

<220> 
<221> VARIANT        
<222> (1)..(4)
<223> Linkages between each nucleoside as shown in Table 8 of the
      specification. Nucleosides modified as shown in Table 8 of
      the specification.

<400> 32
cuuc                                                              4

<210> 33
<211> 18
<212> RNA
<213> Artificial Sequence

<220> 
<223> Synthetic Construct

<220> 
<221> VARIANT        
<222> (1)..(18)
<223> Linkages between each nucleoside as shown in Table 8 of the
      specification. Nucleosides modified as shown in Table 8 of
      the specification.

<400> 33
cagaccuucc agaccuuc                                               18

<210> 34
<211> 18
<212> RNA
<213> Artificial Sequence

<220> 
<223> Synthetic Construct

<220> 
<221> VARIANT        
<222> (1)..(18)
<223> Linkages between each nucleoside as shown in Table 8 of the
      specification. Nucleosides modified as shown in Table 8 of
      the specification.

<400> 34
cagaccuucc agaccuuc                                               18

<210> 35
<211> 18
<212> RNA
<213> Artificial Sequence

<220> 
<223> Synthetic Construct

<220> 
<221> VARIANT        
<222> (1)..(18)
<223> Linkages between each nucleoside as shown in Table 8 of the
      specification. Nucleosides modified as shown in Table 8 of
      the specification.

<400> 35
cagaccuucc agaccuuc                                               18

<210> 36
<211> 4
<212> RNA
<213> Artificial Sequence

<220> 
<223> Synthetic Construct

<220> 
<221> VARIANT        
<222> (1)..(4)
<223> Linkages between each nucleoside as shown in Table 8 of the
      specification. Nucleosides modified as shown in Table 8 of
      the specification.

<400> 36
cuuc                                                              4

<210> 37
<211> 4
<212> RNA
<213> Artificial Sequence

<220> 
<223> Synthetic Construct

<220> 
<221> VARIANT        
<222> (1)..(4)
<223> Linkages between each nucleoside as shown in Table 8 of the
      specification. Nucleosides modified as shown in Table 8 of
      the specification.

<400> 37
cuuc                                                              4

<210> 38
<211> 4
<212> RNA
<213> Artificial Sequence

<220> 
<223> Synthetic Construct

<220> 
<221> VARIANT        
<222> (1)..(4)
<223> Linkages between each nucleoside as shown in Table 8 of the
      specification. Nucleosides modified as shown in Table 8 of
      the specification.

<400> 38
cuuc                                                              4

<210> 39
<211> 3
<212> RNA
<213> Artificial Sequence

<220> 
<223> Synthetic Construct

<220> 
<221> VARIANT        
<222> (1)..(3)
<223> Linkages between each nucleoside as shown in Table 8 of the
      specification. Nucleosides modified as shown in Table 8 of
      the specification.

<400> 39
uuc                                                               3

<210> 40
<211> 3
<212> RNA
<213> Artificial Sequence

<220> 
<223> Synthetic Construct

<220> 
<221> VARIANT        
<222> (1)..(3)
<223> Linkages between each nucleoside as shown in Table 8 of the
      specification. Nucleosides modified as shown in Table 8 of
      the specification.

<400> 40
uuc                                                               3

<210> 41
<211> 3
<212> RNA
<213> Artificial Sequence

<220> 
<223> Synthetic Construct

<220> 
<221> VARIANT        
<222> (1)..(3)
<223> Linkages between each nucleoside as shown in Table 8 of the
      specification. Nucleosides modified as shown in Table 8 of
      the specification.

<400> 41
uuc                                                               3

<210> 42
<211> 3
<212> RNA
<213> Artificial Sequence

<220> 
<223> Synthetic Construct

<220> 
<221> VARIANT        
<222> (1)..(3)
<223> Linkages between each nucleoside as shown in Table 8 of the
      specification. Nucleosides modified as shown in Table 8 of
      the specification.

<400> 42
cuc                                                               3

<210> 43
<211> 3
<212> RNA
<213> Artificial Sequence

<220> 
<223> Synthetic Construct

<220> 
<221> VARIANT        
<222> (1)..(3)
<223> Linkages between each nucleoside as shown in Table 8 of the
      specification. Nucleosides modified as shown in Table 8 of
      the specification.

<400> 43
cuc                                                               3

<210> 44
<211> 6
<212> RNA
<213> Artificial Sequence

<220> 
<223> Synthetic Construct

<220> 
<221> VARIANT        
<222> (1)..(6)
<223> Linkages between each nucleoside as shown in Table 8 of the
      specification. Nucleosides modified as shown in Table 8 of
      the specification.

<400> 44
cuuuuc                                                            6

<210> 45
<211> 6
<212> RNA
<213> Artificial Sequence

<220> 
<223> Synthetic Construct

<220> 
<221> VARIANT        
<222> (1)..(6)
<223> Linkages between each nucleoside as shown in Table 8 of the
      specification. Nucleosides modified as shown in Table 8 of
      the specification.

<400> 45
cuuuuc                                                            6

<210> 46
<211> 6
<212> RNA
<213> Artificial Sequence

<220> 
<223> Synthetic Construct

<220> 
<221> VARIANT        
<222> (1)..(6)
<223> Linkages between each nucleoside as shown in Table 8 of the
      specification. Nucleosides modified as shown in Table 8 of
      the specification.

<400> 46
cuuuuc                                                            6

<210> 47
<211> 6
<212> RNA
<213> Artificial Sequence

<220> 
<223> Synthetic Construct

<220> 
<221> VARIANT        
<222> (1)..(6)
<223> Linkages between each nucleoside as shown in Table 8 of the
      specification. Nucleosides modified as shown in Table 8 of
      the specification.

<400> 47
cuuuuc                                                            6

<210> 48
<211> 6
<212> RNA
<213> Artificial Sequence

<220> 
<223> Synthetic Construct

<220> 
<221> VARIANT        
<222> (1)..(6)
<223> Linkages between each nucleoside as shown in Table 8 of the
      specification. Nucleosides modified as shown in Table 8 of
      the specification.

<400> 48
cuuuuc                                                            6

<210> 49
<211> 6
<212> RNA
<213> Artificial Sequence

<220> 
<223> Synthetic Construct

<220> 
<221> VARIANT        
<222> (1)..(6)
<223> Linkages between each nucleoside as shown in Table 8 of the
      specification. Nucleosides modified as shown in Table 8 of
      the specification.

<400> 49
cuuuuc                                                            6

<210> 50
<211> 6
<212> RNA
<213> Artificial Sequence

<220> 
<223> Synthetic Construct

<220> 
<221> VARIANT        
<222> (1)..(6)
<223> Linkages between each nucleoside as shown in Table 8 of the
      specification. Nucleosides modified as shown in Table 8 of
      the specification.

<400> 50
cuuuuc                                                            6

<210> 51
<211> 6
<212> RNA
<213> Artificial Sequence

<220> 
<223> Synthetic Construct

<220> 
<221> VARIANT        
<222> (1)..(6)
<223> Linkages between each nucleoside as shown in Table 8 of the
      specification. Nucleosides modified as shown in Table 8 of
      the specification.

<400> 51
cuuuuc                                                            6

<210> 52
<211> 3
<212> RNA
<213> Artificial Sequence

<220> 
<223> Synthetic Construct

<220> 
<221> VARIANT        
<222> (1)..(3)
<223> Linkages between each nucleoside as shown in Table 8 of the
      specification. Nucleosides modified as shown in Table 8 of
      the specification.

<220> 
<221> misc_feature   
<222> 1
<223> n = 2'-Fluoro-U or 2'O-methyl-U

<400> 52
nuc                                                               3

<210> 53
<211> 3
<212> RNA
<213> Artificial Sequence

<220> 
<223> Synthetic Construct

<220> 
<221> VARIANT        
<222> (1)..(3)
<223> Linkages between each nucleoside as shown in Table 8 of the
      specification. Nucleosides modified as shown in Table 8 of
      the specification.

<220> 
<221> misc_feature   
<222> 1, 3
<223> n = 2'-Fluoro-U or 2'O-methyl-U

<400> 53
nun                                                               3

<210> 54
<211> 3
<212> RNA
<213> Artificial Sequence

<220> 
<223> Synthetic Construct

<220> 
<221> VARIANT        
<222> (1)..(3)
<223> Linkages between each nucleoside as shown in Table 8 of the
      specification. Nucleosides modified as shown in Table 8 of
      the specification.

<400> 54
cuu                                                               3

<210> 55
<211> 3
<212> RNA
<213> Artificial Sequence

<220> 
<223> Synthetic Construct

<220> 
<221> VARIANT        
<222> (1)..(3)
<223> Linkages between each nucleoside as shown in Table 8 of the
      specification. Nucleosides modified as shown in Table 8 of
      the specification.

<400> 55
uuc                                                               3

<210> 56
<211> 19
<212> RNA
<213> Artificial Sequence

<220> 
<223> Synthetic Construct

<220> 
<221> VARIANT        
<222> (1)..(19)
<223> Linkages between each nucleoside as shown in Table 8 of the
      specification. Nucleosides modified as shown in Table 8 of
      the specification.

<400> 56
agcuuaaccu guccuucaa                                              19

<210> 57
<211> 6
<212> RNA
<213> Artificial Sequence

<220> 
<223> Synthetic Construct

<220> 
<221> VARIANT        
<222> (1)..(6)
<223> Linkages between each nucleoside as shown in Table 8 of the
      specification. Nucleosides modified as shown in Table 8 of
      the specification.

<400> 57
cuuuuc                                                            6

<210> 58
<211> 8
<212> RNA
<213> Artificial Sequence

<220> 
<223> Synthetic Construct

<220> 
<221> VARIANT        
<222> (1)..(8)
<223> Linkages between each nucleoside as shown in Table 8 of the
      specification. Nucleosides modified as shown in Table 8 of
      the specification.

<400> 58
ccgagccg                                                          8

<210> 59
<211> 2
<212> RNA
<213> Artificial Sequence

<220> 
<223> Synthetic Construct

<220> 
<221> VARIANT        
<222> (1)..(2)
<223> Linkages between each nucleoside as shown in Table 8 of the
      specification. Nucleosides modified as shown in Table 8 of
      the specification.

<400> 59
cc                                                                2

<210> 60
<211> 3
<212> RNA
<213> Artificial Sequence

<220> 
<223> Synthetic Construct

<220> 
<221> VARIANT        
<222> (1)..(3)
<223> Linkages between each nucleoside as shown in Table 8 of the
      specification. Nucleosides modified as shown in Table 8 of
      the specification.

<400> 60
cgg                                                               3

<210> 61
<211> 15
<212> RNA
<213> Artificial Sequence

<220> 
<223> Synthetic Construct

<220> 
<221> VARIANT        
<222> (1)..(15)
<223> Linkages between each nucleoside as shown in Table 8 of the
      specification. Nucleosides modified as shown in Table 8 of
      the specification.

<400> 61
ggcagaagcc gggcc                                                  15

<210> 62
<211> 55
<212> RNA
<213> Artificial Sequence

<220> 
<223> Synthetic Construct

<220> 
<221> VARIANT        
<222> (1)..(55)
<223> Linkages between each nucleoside as shown in Table 8 of the
      specification. Nucleosides modified as shown in Table 8 of
      the specification.

<400> 62
gggacgcuga cccagaagau cacuagaaau aguagaucuu cugggucagc guccc      55

<210> 63
<211> 3
<212> RNA
<213> Artificial Sequence

<220> 
<223> Synthetic Construct

<220> 
<221> VARIANT        
<222> (1)..(3)
<223> Linkages between each nucleoside as shown in Table 8 of the
      specification. Nucleosides modified as shown in Table 8 of
      the specification.

<220> 
<221> misc_feature   
<222> 1, 3
<223> n = any nucleoside

<400> 63
nun                                                               3

<210> 64
<211> 3
<212> RNA
<213> Artificial Sequence

<220> 
<223> Synthetic Construct

<220> 
<221> VARIANT        
<222> (1)..(3)
<223> Linkages between each nucleoside as shown in Table 8 of the
      specification. Nucleosides modified as shown in Table 8 of
      the specification.

<220> 
<221> misc_feature   
<222> 1, 3
<223> n = any nucleoside

<400> 64
nun                                                               3

<210> 65
<211> 76
<212> DNA
<213> Artificial Sequence

<220> 
<223> Synthetic Construct

<220> 
<221> VARIANT        
<222> (1)..(76)
<223> Linkages between each nucleoside as shown in Table 8 of the
      specification. Nucleosides modified as shown in Table 8 of
      the specification.

<400> 65
ttgtaatacg actcactata gggacgctga cccagaagat ctactagaaa tagtagatct 60
tctgggtcag cgtccc                                                 76

<210> 66
<211> 76
<212> DNA
<213> Artificial Sequence

<220> 
<223> Synthetic Construct

<220> 
<221> VARIANT        
<222> (1)..(76)
<223> Linkages between each nucleoside as shown in Table 8 of the
      specification. Nucleosides modified as shown in Table 8 of
      the specification.

<400> 66
gggacgctga cccagaagat ctactatttc tagtagatct tctgggtcag cgtccctata 60
gtgagtcgta ttacaa                                                 76

<210> 67
<211> 5
<212> RNA
<213> Artificial Sequence

<220> 
<223> Synthetic Construct

<220> 
<221> VARIANT        
<222> (1)..(5)
<223> Linkages between each nucleoside as shown in Table 8 of the
      specification. Nucleosides modified as shown in Table 8 of
      the specification.

<400> 67
cagac                                                             5

<210> 68
<211> 8
<212> RNA
<213> Artificial Sequence

<220> 
<223> Synthetic Construct

<220> 
<221> VARIANT        
<222> (1)..(8)
<223> Linkages between each nucleoside as shown in Table 8 of the
      specification. Nucleosides modified as shown in Table 8 of
      the specification.

<400> 68
ccgagccg                                                          8

<210> 69
<211> 3
<212> RNA
<213> Artificial Sequence

<220> 
<223> Synthetic Construct

<220> 
<221> VARIANT        
<222> (1)..(3)
<223> Linkages between each nucleoside as shown in Table 8 of the
      specification. Nucleosides modified as shown in Table 8 of
      the specification.

<400> 69
ggg                                                               3

<210> 70
<211> 20
<212> RNA
<213> Artificial Sequence

<220> 
<223> Synthetic Construct

<220> 
<221> VARIANT        
<222> (1)..(20)
<223> Linkages between each nucleoside as shown in Table 8 of the
      specification. Nucleosides modified as shown in Table 8 of
      the specification.

<400> 70
cacacacaca cacacacaca                                             20

<210> 71
<211> 20
<212> RNA
<213> Artificial Sequence

<220> 
<223> Synthetic Construct

<220> 
<221> VARIANT        
<222> (1)..(20)
<223> Linkages between each nucleoside as shown in Table 8 of the
      specification. Nucleosides modified as shown in Table 8 of
      the specification.

<400> 71
gguuguuguu guuguuguug                                             20

<210> 72
<211> 20
<212> RNA
<213> Artificial Sequence

<220> 
<223> Synthetic Construct

<220> 
<221> VARIANT        
<222> (1)..(20)
<223> Linkages between each nucleoside as shown in Table 8 of the
      specification. Nucleosides modified as shown in Table 8 of
      the specification.

<400> 72
gguuguuguu guuguuguug                                             20
