                               SEQUENCE LISTING

<110> INTELLIA THERAPEUTICS, INC.
 
<120> LIPID NANOPARTICLE COMPOSITIONS

<130> ILH-00925

<140> PCT/US2022/025076
<141> 2022-04-15

<150> 63/316,568
<151> 2022-03-04

<150> 63/274,153
<151> 2021-11-01

<150> 63/254,948
<151> 2021-10-12

<150> 63/176,227
<151> 2021-04-17

<160> 19    

<170> PatentIn version 3.5

<210> 1
<211> 4140
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      polynucleotide

<400> 1
atggacaaga agtacagcat cggactggac atcggaacaa acagcgtcgg atgggcagtc       60

atcacagacg aatacaaggt cccgagcaag aagttcaagg tcctgggaaa cacagacaga      120

cacagcatca agaagaacct gatcggagca ctgctgttcg acagcggaga aacagcagaa      180

gcaacaagac tgaagagaac agcaagaaga agatacacaa gaagaaagaa cagaatctgc      240

tacctgcagg aaatcttcag caacgaaatg gcaaaggtcg acgacagctt cttccacaga      300

ctggaagaaa gcttcctggt cgaagaagac aagaagcacg aaagacaccc gatcttcgga      360

aacatcgtcg acgaagtcgc ataccacgaa aagtacccga caatctacca cctgagaaag      420

aagctggtcg acagcacaga caaggcagac ctgagactga tctacctggc actggcacac      480

atgatcaagt tcagaggaca cttcctgatc gaaggagacc tgaacccgga caacagcgac      540

gtcgacaagc tgttcatcca gctggtccag acatacaacc agctgttcga agaaaacccg      600

atcaacgcaa gcggagtcga cgcaaaggca atcctgagcg caagactgag caagagcaga      660

agactggaaa acctgatcgc acagctgccg ggagaaaaga agaacggact gttcggaaac      720

ctgatcgcac tgagcctggg actgacaccg aacttcaaga gcaacttcga cctggcagaa      780

gacgcaaagc tgcagctgag caaggacaca tacgacgacg acctggacaa cctgctggca      840

cagatcggag accagtacgc agacctgttc ctggcagcaa agaacctgag cgacgcaatc      900

ctgctgagcg acatcctgag agtcaacaca gaaatcacaa aggcaccgct gagcgcaagc      960

atgatcaaga gatacgacga acaccaccag gacctgacac tgctgaaggc actggtcaga     1020

cagcagctgc cggaaaagta caaggaaatc ttcttcgacc agagcaagaa cggatacgca     1080

ggatacatcg acggaggagc aagccaggaa gaattctaca agttcatcaa gccgatcctg     1140

gaaaagatgg acggaacaga agaactgctg gtcaagctga acagagaaga cctgctgaga     1200

aagcagagaa cattcgacaa cggaagcatc ccgcaccaga tccacctggg agaactgcac     1260

gcaatcctga gaagacagga agacttctac ccgttcctga aggacaacag agaaaagatc     1320

gaaaagatcc tgacattcag aatcccgtac tacgtcggac cgctggcaag aggaaacagc     1380

agattcgcat ggatgacaag aaagagcgaa gaaacaatca caccgtggaa cttcgaagaa     1440

gtcgtcgaca agggagcaag cgcacagagc ttcatcgaaa gaatgacaaa cttcgacaag     1500

aacctgccga acgaaaaggt cctgccgaag cacagcctgc tgtacgaata cttcacagtc     1560

tacaacgaac tgacaaaggt caagtacgtc acagaaggaa tgagaaagcc ggcattcctg     1620

agcggagaac agaagaaggc aatcgtcgac ctgctgttca agacaaacag aaaggtcaca     1680

gtcaagcagc tgaaggaaga ctacttcaag aagatcgaat gcttcgacag cgtcgaaatc     1740

agcggagtcg aagacagatt caacgcaagc ctgggaacat accacgacct gctgaagatc     1800

atcaaggaca aggacttcct ggacaacgaa gaaaacgaag acatcctgga agacatcgtc     1860

ctgacactga cactgttcga agacagagaa atgatcgaag aaagactgaa gacatacgca     1920

cacctgttcg acgacaaggt catgaagcag ctgaagagaa gaagatacac aggatgggga     1980

agactgagca gaaagctgat caacggaatc agagacaagc agagcggaaa gacaatcctg     2040

gacttcctga agagcgacgg attcgcaaac agaaacttca tgcagctgat ccacgacgac     2100

agcctgacat tcaaggaaga catccagaag gcacaggtca gcggacaggg agacagcctg     2160

cacgaacaca tcgcaaacct ggcaggaagc ccggcaatca agaagggaat cctgcagaca     2220

gtcaaggtcg tcgacgaact ggtcaaggtc atgggaagac acaagccgga aaacatcgtc     2280

atcgaaatgg caagagaaaa ccagacaaca cagaagggac agaagaacag cagagaaaga     2340

atgaagagaa tcgaagaagg aatcaaggaa ctgggaagcc agatcctgaa ggaacacccg     2400

gtcgaaaaca cacagctgca gaacgaaaag ctgtacctgt actacctgca gaacggaaga     2460

gacatgtacg tcgaccagga actggacatc aacagactga gcgactacga cgtcgaccac     2520

atcgtcccgc agagcttcct gaaggacgac agcatcgaca acaaggtcct gacaagaagc     2580

gacaagaaca gaggaaagag cgacaacgtc ccgagcgaag aagtcgtcaa gaagatgaag     2640

aactactgga gacagctgct gaacgcaaag ctgatcacac agagaaagtt cgacaacctg     2700

acaaaggcag agagaggagg actgagcgaa ctggacaagg caggattcat caagagacag     2760

ctggtcgaaa caagacagat cacaaagcac gtcgcacaga tcctggacag cagaatgaac     2820

acaaagtacg acgaaaacga caagctgatc agagaagtca aggtcatcac actgaagagc     2880

aagctggtca gcgacttcag aaaggacttc cagttctaca aggtcagaga aatcaacaac     2940

taccaccacg cacacgacgc atacctgaac gcagtcgtcg gaacagcact gatcaagaag     3000

tacccgaagc tggaaagcga attcgtctac ggagactaca aggtctacga cgtcagaaag     3060

atgatcgcaa agagcgaaca ggaaatcgga aaggcaacag caaagtactt cttctacagc     3120

aacatcatga acttcttcaa gacagaaatc acactggcaa acggagaaat cagaaagaga     3180

ccgctgatcg aaacaaacgg agaaacagga gaaatcgtct gggacaaggg aagagacttc     3240

gcaacagtca gaaaggtcct gagcatgccg caggtcaaca tcgtcaagaa gacagaagtc     3300

cagacaggag gattcagcaa ggaaagcatc ctgccgaaga gaaacagcga caagctgatc     3360

gcaagaaaga aggactggga cccgaagaag tacggaggat tcgacagccc gacagtcgca     3420

tacagcgtcc tggtcgtcgc aaaggtcgaa aagggaaaga gcaagaagct gaagagcgtc     3480

aaggaactgc tgggaatcac aatcatggaa agaagcagct tcgaaaagaa cccgatcgac     3540

ttcctggaag caaagggata caaggaagtc aagaaggacc tgatcatcaa gctgccgaag     3600

tacagcctgt tcgaactgga aaacggaaga aagagaatgc tggcaagcgc aggagaactg     3660

cagaagggaa acgaactggc actgccgagc aagtacgtca acttcctgta cctggcaagc     3720

cactacgaaa agctgaaggg aagcccggaa gacaacgaac agaagcagct gttcgtcgaa     3780

cagcacaagc actacctgga cgaaatcatc gaacagatca gcgaattcag caagagagtc     3840

atcctggcag acgcaaacct ggacaaggtc ctgagcgcat acaacaagca cagagacaag     3900

ccgatcagag aacaggcaga aaacatcatc cacctgttca cactgacaaa cctgggagca     3960

ccggcagcat tcaagtactt cgacacaaca atcgacagaa agagatacac aagcacaaag     4020

gaagtcctgg acgcaacact gatccaccag agcatcacag gactgtacga aacaagaatc     4080

gacctgagcc agctgggagg agacggagga ggaagcccga agaagaagag aaaggtctag     4140


<210> 2
<211> 4140
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      polynucleotide

<400> 2
atggacaaga agtactccat cggcctggac atcggcacca actccgtggg ctgggccgtg       60

atcaccgacg agtacaaggt gccctccaag aagttcaagg tgctgggcaa caccgaccgg      120

cactccatca agaagaacct gatcggcgcc ctgctgttcg actccggcga gaccgccgag      180

gccacccggc tgaagcggac cgcccggcgg cggtacaccc ggcggaagaa ccggatctgc      240

tacctgcagg agatcttctc caacgagatg gccaaggtgg acgactcctt cttccaccgg      300

ctggaggagt ccttcctggt ggaggaggac aagaagcacg agcggcaccc catcttcggc      360

aacatcgtgg acgaggtggc ctaccacgag aagtacccca ccatctacca cctgcggaag      420

aagctggtgg actccaccga caaggccgac ctgcggctga tctacctggc cctggcccac      480

atgatcaagt tccggggcca cttcctgatc gagggcgacc tgaaccccga caactccgac      540

gtggacaagc tgttcatcca gctggtgcag acctacaacc agctgttcga ggagaacccc      600

atcaacgcct ccggcgtgga cgccaaggcc atcctgtccg cccggctgtc caagtcccgg      660

cggctggaga acctgatcgc ccagctgccc ggcgagaaga agaacggcct gttcggcaac      720

ctgatcgccc tgtccctggg cctgaccccc aacttcaagt ccaacttcga cctggccgag      780

gacgccaagc tgcagctgtc caaggacacc tacgacgacg acctggacaa cctgctggcc      840

cagatcggcg accagtacgc cgacctgttc ctggccgcca agaacctgtc cgacgccatc      900

ctgctgtccg acatcctgcg ggtgaacacc gagatcacca aggcccccct gtccgcctcc      960

atgatcaagc ggtacgacga gcaccaccag gacctgaccc tgctgaaggc cctggtgcgg     1020

cagcagctgc ccgagaagta caaggagatc ttcttcgacc agtccaagaa cggctacgcc     1080

ggctacatcg acggcggcgc ctcccaggag gagttctaca agttcatcaa gcccatcctg     1140

gagaagatgg acggcaccga ggagctgctg gtgaagctga accgggagga cctgctgcgg     1200

aagcagcgga ccttcgacaa cggctccatc ccccaccaga tccacctggg cgagctgcac     1260

gccatcctgc ggcggcagga ggacttctac cccttcctga aggacaaccg ggagaagatc     1320

gagaagatcc tgaccttccg gatcccctac tacgtgggcc ccctggcccg gggcaactcc     1380

cggttcgcct ggatgacccg gaagtccgag gagaccatca ccccctggaa cttcgaggag     1440

gtggtggaca agggcgcctc cgcccagtcc ttcatcgagc ggatgaccaa cttcgacaag     1500

aacctgccca acgagaaggt gctgcccaag cactccctgc tgtacgagta cttcaccgtg     1560

tacaacgagc tgaccaaggt gaagtacgtg accgagggca tgcggaagcc cgccttcctg     1620

tccggcgagc agaagaaggc catcgtggac ctgctgttca agaccaaccg gaaggtgacc     1680

gtgaagcagc tgaaggagga ctacttcaag aagatcgagt gcttcgactc cgtggagatc     1740

tccggcgtgg aggaccggtt caacgcctcc ctgggcacct accacgacct gctgaagatc     1800

atcaaggaca aggacttcct ggacaacgag gagaacgagg acatcctgga ggacatcgtg     1860

ctgaccctga ccctgttcga ggaccgggag atgatcgagg agcggctgaa gacctacgcc     1920

cacctgttcg acgacaaggt gatgaagcag ctgaagcggc ggcggtacac cggctggggc     1980

cggctgtccc ggaagctgat caacggcatc cgggacaagc agtccggcaa gaccatcctg     2040

gacttcctga agtccgacgg cttcgccaac cggaacttca tgcagctgat ccacgacgac     2100

tccctgacct tcaaggagga catccagaag gcccaggtgt ccggccaggg cgactccctg     2160

cacgagcaca tcgccaacct ggccggctcc cccgccatca agaagggcat cctgcagacc     2220

gtgaaggtgg tggacgagct ggtgaaggtg atgggccggc acaagcccga gaacatcgtg     2280

atcgagatgg cccgggagaa ccagaccacc cagaagggcc agaagaactc ccgggagcgg     2340

atgaagcgga tcgaggaggg catcaaggag ctgggctccc agatcctgaa ggagcacccc     2400

gtggagaaca cccagctgca gaacgagaag ctgtacctgt actacctgca gaacggccgg     2460

gacatgtacg tggaccagga gctggacatc aaccggctgt ccgactacga cgtggaccac     2520

atcgtgcccc agtccttcct gaaggacgac tccatcgaca acaaggtgct gacccggtcc     2580

gacaagaacc ggggcaagtc cgacaacgtg ccctccgagg aggtggtgaa gaagatgaag     2640

aactactggc ggcagctgct gaacgccaag ctgatcaccc agcggaagtt cgacaacctg     2700

accaaggccg agcggggcgg cctgtccgag ctggacaagg ccggcttcat caagcggcag     2760

ctggtggaga cccggcagat caccaagcac gtggcccaga tcctggactc ccggatgaac     2820

accaagtacg acgagaacga caagctgatc cgggaggtga aggtgatcac cctgaagtcc     2880

aagctggtgt ccgacttccg gaaggacttc cagttctaca aggtgcggga gatcaacaac     2940

taccaccacg cccacgacgc ctacctgaac gccgtggtgg gcaccgccct gatcaagaag     3000

taccccaagc tggagtccga gttcgtgtac ggcgactaca aggtgtacga cgtgcggaag     3060

atgatcgcca agtccgagca ggagatcggc aaggccaccg ccaagtactt cttctactcc     3120

aacatcatga acttcttcaa gaccgagatc accctggcca acggcgagat ccggaagcgg     3180

cccctgatcg agaccaacgg cgagaccggc gagatcgtgt gggacaaggg ccgggacttc     3240

gccaccgtgc ggaaggtgct gtccatgccc caggtgaaca tcgtgaagaa gaccgaggtg     3300

cagaccggcg gcttctccaa ggagtccatc ctgcccaagc ggaactccga caagctgatc     3360

gcccggaaga aggactggga ccccaagaag tacggcggct tcgactcccc caccgtggcc     3420

tactccgtgc tggtggtggc caaggtggag aagggcaagt ccaagaagct gaagtccgtg     3480

aaggagctgc tgggcatcac catcatggag cggtcctcct tcgagaagaa ccccatcgac     3540

ttcctggagg ccaagggcta caaggaggtg aagaaggacc tgatcatcaa gctgcccaag     3600

tactccctgt tcgagctgga gaacggccgg aagcggatgc tggcctccgc cggcgagctg     3660

cagaagggca acgagctggc cctgccctcc aagtacgtga acttcctgta cctggcctcc     3720

cactacgaga agctgaaggg ctcccccgag gacaacgagc agaagcagct gttcgtggag     3780

cagcacaagc actacctgga cgagatcatc gagcagatct ccgagttctc caagcgggtg     3840

atcctggccg acgccaacct ggacaaggtg ctgtccgcct acaacaagca ccgggacaag     3900

cccatccggg agcaggccga gaacatcatc cacctgttca ccctgaccaa cctgggcgcc     3960

cccgccgcct tcaagtactt cgacaccacc atcgaccgga agcggtacac ctccaccaag     4020

gaggtgctgg acgccaccct gatccaccag tccatcaccg gcctgtacga gacccggatc     4080

gacctgtccc agctgggcgg cgacggcggc ggctccccca agaagaagcg gaaggtgtga     4140


<210> 3
<211> 4197
<212> RNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      polynucleotide

<400> 3
auggacaaga aguacuccau cggccuggac aucggcacca acuccguggg cugggccgug       60

aucaccgacg aguacaaggu gcccuccaag aaguucaagg ugcugggcaa caccgaccgg      120

cacuccauca agaagaaccu gaucggcgcc cugcuguucg acuccggcga gaccgccgag      180

gccacccggc ugaagcggac cgcccggcgg cgguacaccc ggcggaagaa ccggaucugc      240

uaccugcagg agaucuucuc caacgagaug gccaaggugg acgacuccuu cuuccaccgg      300

cuggaggagu ccuuccuggu ggaggaggac aagaagcacg agcggcaccc caucuucggc      360

aacaucgugg acgagguggc cuaccacgag aaguacccca ccaucuacca ccugcggaag      420

aagcuggugg acuccaccga caaggccgac cugcggcuga ucuaccuggc ccuggcccac      480

augaucaagu uccggggcca cuuccugauc gagggcgacc ugaaccccga caacuccgac      540

guggacaagc uguucaucca gcuggugcag accuacaacc agcuguucga ggagaacccc      600

aucaacgccu ccggcgugga cgccaaggcc auccuguccg cccggcuguc caagucccgg      660

cggcuggaga accugaucgc ccagcugccc ggcgagaaga agaacggccu guucggcaac      720

cugaucgccc ugucccuggg ccugaccccc aacuucaagu ccaacuucga ccuggccgag      780

gacgccaagc ugcagcuguc caaggacacc uacgacgacg accuggacaa ccugcuggcc      840

cagaucggcg accaguacgc cgaccuguuc cuggccgcca agaaccuguc cgacgccauc      900

cugcuguccg acauccugcg ggugaacacc gagaucacca aggccccccu guccgccucc      960

augaucaagc gguacgacga gcaccaccag gaccugaccc ugcugaaggc ccuggugcgg     1020

cagcagcugc ccgagaagua caaggagauc uucuucgacc aguccaagaa cggcuacgcc     1080

ggcuacaucg acggcggcgc cucccaggag gaguucuaca aguucaucaa gcccauccug     1140

gagaagaugg acggcaccga ggagcugcug gugaagcuga accgggagga ccugcugcgg     1200

aagcagcgga ccuucgacaa cggcuccauc ccccaccaga uccaccuggg cgagcugcac     1260

gccauccugc ggcggcagga ggacuucuac cccuuccuga aggacaaccg ggagaagauc     1320

gagaagaucc ugaccuuccg gauccccuac uacgugggcc cccuggcccg gggcaacucc     1380

cgguucgccu ggaugacccg gaaguccgag gagaccauca cccccuggaa cuucgaggag     1440

gugguggaca agggcgccuc cgcccagucc uucaucgagc ggaugaccaa cuucgacaag     1500

aaccugccca acgagaaggu gcugcccaag cacucccugc uguacgagua cuucaccgug     1560

uacaacgagc ugaccaaggu gaaguacgug accgagggca ugcggaagcc cgccuuccug     1620

uccggcgagc agaagaaggc caucguggac cugcuguuca agaccaaccg gaaggugacc     1680

gugaagcagc ugaaggagga cuacuucaag aagaucgagu gcuucgacuc cguggagauc     1740

uccggcgugg aggaccgguu caacgccucc cugggcaccu accacgaccu gcugaagauc     1800

aucaaggaca aggacuuccu ggacaacgag gagaacgagg acauccugga ggacaucgug     1860

cugacccuga cccuguucga ggaccgggag augaucgagg agcggcugaa gaccuacgcc     1920

caccuguucg acgacaaggu gaugaagcag cugaagcggc ggcgguacac cggcuggggc     1980

cggcuguccc ggaagcugau caacggcauc cgggacaagc aguccggcaa gaccauccug     2040

gacuuccuga aguccgacgg cuucgccaac cggaacuuca ugcagcugau ccacgacgac     2100

ucccugaccu ucaaggagga cauccagaag gcccaggugu ccggccaggg cgacucccug     2160

cacgagcaca ucgccaaccu ggccggcucc cccgccauca agaagggcau ccugcagacc     2220

gugaaggugg uggacgagcu ggugaaggug augggccggc acaagcccga gaacaucgug     2280

aucgagaugg cccgggagaa ccagaccacc cagaagggcc agaagaacuc ccgggagcgg     2340

augaagcgga ucgaggaggg caucaaggag cugggcuccc agauccugaa ggagcacccc     2400

guggagaaca cccagcugca gaacgagaag cuguaccugu acuaccugca gaacggccgg     2460

gacauguacg uggaccagga gcuggacauc aaccggcugu ccgacuacga cguggaccac     2520

aucgugcccc aguccuuccu gaaggacgac uccaucgaca acaaggugcu gacccggucc     2580

gacaagaacc ggggcaaguc cgacaacgug cccuccgagg agguggugaa gaagaugaag     2640

aacuacuggc ggcagcugcu gaacgccaag cugaucaccc agcggaaguu cgacaaccug     2700

accaaggccg agcggggcgg ccuguccgag cuggacaagg ccggcuucau caagcggcag     2760

cugguggaga cccggcagau caccaagcac guggcccaga uccuggacuc ccggaugaac     2820

accaaguacg acgagaacga caagcugauc cgggagguga aggugaucac ccugaagucc     2880

aagcuggugu ccgacuuccg gaaggacuuc caguucuaca aggugcggga gaucaacaac     2940

uaccaccacg cccacgacgc cuaccugaac gccguggugg gcaccgcccu gaucaagaag     3000

uaccccaagc uggaguccga guucguguac ggcgacuaca agguguacga cgugcggaag     3060

augaucgcca aguccgagca ggagaucggc aaggccaccg ccaaguacuu cuucuacucc     3120

aacaucauga acuucuucaa gaccgagauc acccuggcca acggcgagau ccggaagcgg     3180

ccccugaucg agaccaacgg cgagaccggc gagaucgugu gggacaaggg ccgggacuuc     3240

gccaccgugc ggaaggugcu guccaugccc caggugaaca ucgugaagaa gaccgaggug     3300

cagaccggcg gcuucuccaa ggaguccauc cugcccaagc ggaacuccga caagcugauc     3360

gcccggaaga aggacuggga ccccaagaag uacggcggcu ucgacucccc caccguggcc     3420

uacuccgugc uggugguggc caagguggag aagggcaagu ccaagaagcu gaaguccgug     3480

aaggagcugc ugggcaucac caucauggag cgguccuccu ucgagaagaa ccccaucgac     3540

uuccuggagg ccaagggcua caaggaggug aagaaggacc ugaucaucaa gcugcccaag     3600

uacucccugu ucgagcugga gaacggccgg aagcggaugc uggccuccgc cggcgagcug     3660

cagaagggca acgagcuggc ccugcccucc aaguacguga acuuccugua ccuggccucc     3720

cacuacgaga agcugaaggg cucccccgag gacaacgagc agaagcagcu guucguggag     3780

cagcacaagc acuaccugga cgagaucauc gagcagaucu ccgaguucuc caagcgggug     3840

auccuggccg acgccaaccu ggacaaggug cuguccgccu acaacaagca ccgggacaag     3900

cccauccggg agcaggccga gaacaucauc caccuguuca cccugaccaa ccugggcgcc     3960

cccgccgccu ucaaguacuu cgacaccacc aucgaccgga agcgguacac cuccaccaag     4020

gaggugcugg acgccacccu gauccaccag uccaucaccg gccuguacga gacccggauc     4080

gaccuguccc agcugggcgg cgacggcggc ggcuccccca agaagaagcg gaaggugucc     4140

gaguccgcca cccccgaguc cguguccggc uggcggcugu ucaagaagau cuccuga        4197


<210> 4
<211> 1379
<212> PRT
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      polypeptide

<400> 4
Met Asp Lys Lys Tyr Ser Ile Gly Leu Asp Ile Gly Thr Asn Ser Val 
1               5                   10                  15      


Gly Trp Ala Val Ile Thr Asp Glu Tyr Lys Val Pro Ser Lys Lys Phe 
            20                  25                  30          


Lys Val Leu Gly Asn Thr Asp Arg His Ser Ile Lys Lys Asn Leu Ile 
        35                  40                  45              


Gly Ala Leu Leu Phe Asp Ser Gly Glu Thr Ala Glu Ala Thr Arg Leu 
    50                  55                  60                  


Lys Arg Thr Ala Arg Arg Arg Tyr Thr Arg Arg Lys Asn Arg Ile Cys 
65                  70                  75                  80  


Tyr Leu Gln Glu Ile Phe Ser Asn Glu Met Ala Lys Val Asp Asp Ser 
                85                  90                  95      


Phe Phe His Arg Leu Glu Glu Ser Phe Leu Val Glu Glu Asp Lys Lys 
            100                 105                 110         


His Glu Arg His Pro Ile Phe Gly Asn Ile Val Asp Glu Val Ala Tyr 
        115                 120                 125             


His Glu Lys Tyr Pro Thr Ile Tyr His Leu Arg Lys Lys Leu Val Asp 
    130                 135                 140                 


Ser Thr Asp Lys Ala Asp Leu Arg Leu Ile Tyr Leu Ala Leu Ala His 
145                 150                 155                 160 


Met Ile Lys Phe Arg Gly His Phe Leu Ile Glu Gly Asp Leu Asn Pro 
                165                 170                 175     


Asp Asn Ser Asp Val Asp Lys Leu Phe Ile Gln Leu Val Gln Thr Tyr 
            180                 185                 190         


Asn Gln Leu Phe Glu Glu Asn Pro Ile Asn Ala Ser Gly Val Asp Ala 
        195                 200                 205             


Lys Ala Ile Leu Ser Ala Arg Leu Ser Lys Ser Arg Arg Leu Glu Asn 
    210                 215                 220                 


Leu Ile Ala Gln Leu Pro Gly Glu Lys Lys Asn Gly Leu Phe Gly Asn 
225                 230                 235                 240 


Leu Ile Ala Leu Ser Leu Gly Leu Thr Pro Asn Phe Lys Ser Asn Phe 
                245                 250                 255     


Asp Leu Ala Glu Asp Ala Lys Leu Gln Leu Ser Lys Asp Thr Tyr Asp 
            260                 265                 270         


Asp Asp Leu Asp Asn Leu Leu Ala Gln Ile Gly Asp Gln Tyr Ala Asp 
        275                 280                 285             


Leu Phe Leu Ala Ala Lys Asn Leu Ser Asp Ala Ile Leu Leu Ser Asp 
    290                 295                 300                 


Ile Leu Arg Val Asn Thr Glu Ile Thr Lys Ala Pro Leu Ser Ala Ser 
305                 310                 315                 320 


Met Ile Lys Arg Tyr Asp Glu His His Gln Asp Leu Thr Leu Leu Lys 
                325                 330                 335     


Ala Leu Val Arg Gln Gln Leu Pro Glu Lys Tyr Lys Glu Ile Phe Phe 
            340                 345                 350         


Asp Gln Ser Lys Asn Gly Tyr Ala Gly Tyr Ile Asp Gly Gly Ala Ser 
        355                 360                 365             


Gln Glu Glu Phe Tyr Lys Phe Ile Lys Pro Ile Leu Glu Lys Met Asp 
    370                 375                 380                 


Gly Thr Glu Glu Leu Leu Val Lys Leu Asn Arg Glu Asp Leu Leu Arg 
385                 390                 395                 400 


Lys Gln Arg Thr Phe Asp Asn Gly Ser Ile Pro His Gln Ile His Leu 
                405                 410                 415     


Gly Glu Leu His Ala Ile Leu Arg Arg Gln Glu Asp Phe Tyr Pro Phe 
            420                 425                 430         


Leu Lys Asp Asn Arg Glu Lys Ile Glu Lys Ile Leu Thr Phe Arg Ile 
        435                 440                 445             


Pro Tyr Tyr Val Gly Pro Leu Ala Arg Gly Asn Ser Arg Phe Ala Trp 
    450                 455                 460                 


Met Thr Arg Lys Ser Glu Glu Thr Ile Thr Pro Trp Asn Phe Glu Glu 
465                 470                 475                 480 


Val Val Asp Lys Gly Ala Ser Ala Gln Ser Phe Ile Glu Arg Met Thr 
                485                 490                 495     


Asn Phe Asp Lys Asn Leu Pro Asn Glu Lys Val Leu Pro Lys His Ser 
            500                 505                 510         


Leu Leu Tyr Glu Tyr Phe Thr Val Tyr Asn Glu Leu Thr Lys Val Lys 
        515                 520                 525             


Tyr Val Thr Glu Gly Met Arg Lys Pro Ala Phe Leu Ser Gly Glu Gln 
    530                 535                 540                 


Lys Lys Ala Ile Val Asp Leu Leu Phe Lys Thr Asn Arg Lys Val Thr 
545                 550                 555                 560 


Val Lys Gln Leu Lys Glu Asp Tyr Phe Lys Lys Ile Glu Cys Phe Asp 
                565                 570                 575     


Ser Val Glu Ile Ser Gly Val Glu Asp Arg Phe Asn Ala Ser Leu Gly 
            580                 585                 590         


Thr Tyr His Asp Leu Leu Lys Ile Ile Lys Asp Lys Asp Phe Leu Asp 
        595                 600                 605             


Asn Glu Glu Asn Glu Asp Ile Leu Glu Asp Ile Val Leu Thr Leu Thr 
    610                 615                 620                 


Leu Phe Glu Asp Arg Glu Met Ile Glu Glu Arg Leu Lys Thr Tyr Ala 
625                 630                 635                 640 


His Leu Phe Asp Asp Lys Val Met Lys Gln Leu Lys Arg Arg Arg Tyr 
                645                 650                 655     


Thr Gly Trp Gly Arg Leu Ser Arg Lys Leu Ile Asn Gly Ile Arg Asp 
            660                 665                 670         


Lys Gln Ser Gly Lys Thr Ile Leu Asp Phe Leu Lys Ser Asp Gly Phe 
        675                 680                 685             


Ala Asn Arg Asn Phe Met Gln Leu Ile His Asp Asp Ser Leu Thr Phe 
    690                 695                 700                 


Lys Glu Asp Ile Gln Lys Ala Gln Val Ser Gly Gln Gly Asp Ser Leu 
705                 710                 715                 720 


His Glu His Ile Ala Asn Leu Ala Gly Ser Pro Ala Ile Lys Lys Gly 
                725                 730                 735     


Ile Leu Gln Thr Val Lys Val Val Asp Glu Leu Val Lys Val Met Gly 
            740                 745                 750         


Arg His Lys Pro Glu Asn Ile Val Ile Glu Met Ala Arg Glu Asn Gln 
        755                 760                 765             


Thr Thr Gln Lys Gly Gln Lys Asn Ser Arg Glu Arg Met Lys Arg Ile 
    770                 775                 780                 


Glu Glu Gly Ile Lys Glu Leu Gly Ser Gln Ile Leu Lys Glu His Pro 
785                 790                 795                 800 


Val Glu Asn Thr Gln Leu Gln Asn Glu Lys Leu Tyr Leu Tyr Tyr Leu 
                805                 810                 815     


Gln Asn Gly Arg Asp Met Tyr Val Asp Gln Glu Leu Asp Ile Asn Arg 
            820                 825                 830         


Leu Ser Asp Tyr Asp Val Asp His Ile Val Pro Gln Ser Phe Leu Lys 
        835                 840                 845             


Asp Asp Ser Ile Asp Asn Lys Val Leu Thr Arg Ser Asp Lys Asn Arg 
    850                 855                 860                 


Gly Lys Ser Asp Asn Val Pro Ser Glu Glu Val Val Lys Lys Met Lys 
865                 870                 875                 880 


Asn Tyr Trp Arg Gln Leu Leu Asn Ala Lys Leu Ile Thr Gln Arg Lys 
                885                 890                 895     


Phe Asp Asn Leu Thr Lys Ala Glu Arg Gly Gly Leu Ser Glu Leu Asp 
            900                 905                 910         


Lys Ala Gly Phe Ile Lys Arg Gln Leu Val Glu Thr Arg Gln Ile Thr 
        915                 920                 925             


Lys His Val Ala Gln Ile Leu Asp Ser Arg Met Asn Thr Lys Tyr Asp 
    930                 935                 940                 


Glu Asn Asp Lys Leu Ile Arg Glu Val Lys Val Ile Thr Leu Lys Ser 
945                 950                 955                 960 


Lys Leu Val Ser Asp Phe Arg Lys Asp Phe Gln Phe Tyr Lys Val Arg 
                965                 970                 975     


Glu Ile Asn Asn Tyr His His Ala His Asp Ala Tyr Leu Asn Ala Val 
            980                 985                 990         


Val Gly Thr Ala Leu Ile Lys Lys  Tyr Pro Lys Leu Glu  Ser Glu Phe 
        995                 1000                 1005             


Val Tyr  Gly Asp Tyr Lys Val  Tyr Asp Val Arg Lys  Met Ile Ala 
    1010                 1015                 1020             


Lys Ser  Glu Gln Glu Ile Gly  Lys Ala Thr Ala Lys  Tyr Phe Phe 
    1025                 1030                 1035             


Tyr Ser  Asn Ile Met Asn Phe  Phe Lys Thr Glu Ile  Thr Leu Ala 
    1040                 1045                 1050             


Asn Gly  Glu Ile Arg Lys Arg  Pro Leu Ile Glu Thr  Asn Gly Glu 
    1055                 1060                 1065             


Thr Gly  Glu Ile Val Trp Asp  Lys Gly Arg Asp Phe  Ala Thr Val 
    1070                 1075                 1080             


Arg Lys  Val Leu Ser Met Pro  Gln Val Asn Ile Val  Lys Lys Thr 
    1085                 1090                 1095             


Glu Val  Gln Thr Gly Gly Phe  Ser Lys Glu Ser Ile  Leu Pro Lys 
    1100                 1105                 1110             


Arg Asn  Ser Asp Lys Leu Ile  Ala Arg Lys Lys Asp  Trp Asp Pro 
    1115                 1120                 1125             


Lys Lys  Tyr Gly Gly Phe Asp  Ser Pro Thr Val Ala  Tyr Ser Val 
    1130                 1135                 1140             


Leu Val  Val Ala Lys Val Glu  Lys Gly Lys Ser Lys  Lys Leu Lys 
    1145                 1150                 1155             


Ser Val  Lys Glu Leu Leu Gly  Ile Thr Ile Met Glu  Arg Ser Ser 
    1160                 1165                 1170             


Phe Glu  Lys Asn Pro Ile Asp  Phe Leu Glu Ala Lys  Gly Tyr Lys 
    1175                 1180                 1185             


Glu Val  Lys Lys Asp Leu Ile  Ile Lys Leu Pro Lys  Tyr Ser Leu 
    1190                 1195                 1200             


Phe Glu  Leu Glu Asn Gly Arg  Lys Arg Met Leu Ala  Ser Ala Gly 
    1205                 1210                 1215             


Glu Leu  Gln Lys Gly Asn Glu  Leu Ala Leu Pro Ser  Lys Tyr Val 
    1220                 1225                 1230             


Asn Phe  Leu Tyr Leu Ala Ser  His Tyr Glu Lys Leu  Lys Gly Ser 
    1235                 1240                 1245             


Pro Glu  Asp Asn Glu Gln Lys  Gln Leu Phe Val Glu  Gln His Lys 
    1250                 1255                 1260             


His Tyr  Leu Asp Glu Ile Ile  Glu Gln Ile Ser Glu  Phe Ser Lys 
    1265                 1270                 1275             


Arg Val  Ile Leu Ala Asp Ala  Asn Leu Asp Lys Val  Leu Ser Ala 
    1280                 1285                 1290             


Tyr Asn  Lys His Arg Asp Lys  Pro Ile Arg Glu Gln  Ala Glu Asn 
    1295                 1300                 1305             


Ile Ile  His Leu Phe Thr Leu  Thr Asn Leu Gly Ala  Pro Ala Ala 
    1310                 1315                 1320             


Phe Lys  Tyr Phe Asp Thr Thr  Ile Asp Arg Lys Arg  Tyr Thr Ser 
    1325                 1330                 1335             


Thr Lys  Glu Val Leu Asp Ala  Thr Leu Ile His Gln  Ser Ile Thr 
    1340                 1345                 1350             


Gly Leu  Tyr Glu Thr Arg Ile  Asp Leu Ser Gln Leu  Gly Gly Asp 
    1355                 1360                 1365             


Gly Gly  Gly Ser Pro Lys Lys  Lys Arg Lys Val 
    1370                 1375                 


<210> 5
<211> 1398
<212> PRT
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      polypeptide

<400> 5
Met Asp Lys Lys Tyr Ser Ile Gly Leu Asp Ile Gly Thr Asn Ser Val 
1               5                   10                  15      


Gly Trp Ala Val Ile Thr Asp Glu Tyr Lys Val Pro Ser Lys Lys Phe 
            20                  25                  30          


Lys Val Leu Gly Asn Thr Asp Arg His Ser Ile Lys Lys Asn Leu Ile 
        35                  40                  45              


Gly Ala Leu Leu Phe Asp Ser Gly Glu Thr Ala Glu Ala Thr Arg Leu 
    50                  55                  60                  


Lys Arg Thr Ala Arg Arg Arg Tyr Thr Arg Arg Lys Asn Arg Ile Cys 
65                  70                  75                  80  


Tyr Leu Gln Glu Ile Phe Ser Asn Glu Met Ala Lys Val Asp Asp Ser 
                85                  90                  95      


Phe Phe His Arg Leu Glu Glu Ser Phe Leu Val Glu Glu Asp Lys Lys 
            100                 105                 110         


His Glu Arg His Pro Ile Phe Gly Asn Ile Val Asp Glu Val Ala Tyr 
        115                 120                 125             


His Glu Lys Tyr Pro Thr Ile Tyr His Leu Arg Lys Lys Leu Val Asp 
    130                 135                 140                 


Ser Thr Asp Lys Ala Asp Leu Arg Leu Ile Tyr Leu Ala Leu Ala His 
145                 150                 155                 160 


Met Ile Lys Phe Arg Gly His Phe Leu Ile Glu Gly Asp Leu Asn Pro 
                165                 170                 175     


Asp Asn Ser Asp Val Asp Lys Leu Phe Ile Gln Leu Val Gln Thr Tyr 
            180                 185                 190         


Asn Gln Leu Phe Glu Glu Asn Pro Ile Asn Ala Ser Gly Val Asp Ala 
        195                 200                 205             


Lys Ala Ile Leu Ser Ala Arg Leu Ser Lys Ser Arg Arg Leu Glu Asn 
    210                 215                 220                 


Leu Ile Ala Gln Leu Pro Gly Glu Lys Lys Asn Gly Leu Phe Gly Asn 
225                 230                 235                 240 


Leu Ile Ala Leu Ser Leu Gly Leu Thr Pro Asn Phe Lys Ser Asn Phe 
                245                 250                 255     


Asp Leu Ala Glu Asp Ala Lys Leu Gln Leu Ser Lys Asp Thr Tyr Asp 
            260                 265                 270         


Asp Asp Leu Asp Asn Leu Leu Ala Gln Ile Gly Asp Gln Tyr Ala Asp 
        275                 280                 285             


Leu Phe Leu Ala Ala Lys Asn Leu Ser Asp Ala Ile Leu Leu Ser Asp 
    290                 295                 300                 


Ile Leu Arg Val Asn Thr Glu Ile Thr Lys Ala Pro Leu Ser Ala Ser 
305                 310                 315                 320 


Met Ile Lys Arg Tyr Asp Glu His His Gln Asp Leu Thr Leu Leu Lys 
                325                 330                 335     


Ala Leu Val Arg Gln Gln Leu Pro Glu Lys Tyr Lys Glu Ile Phe Phe 
            340                 345                 350         


Asp Gln Ser Lys Asn Gly Tyr Ala Gly Tyr Ile Asp Gly Gly Ala Ser 
        355                 360                 365             


Gln Glu Glu Phe Tyr Lys Phe Ile Lys Pro Ile Leu Glu Lys Met Asp 
    370                 375                 380                 


Gly Thr Glu Glu Leu Leu Val Lys Leu Asn Arg Glu Asp Leu Leu Arg 
385                 390                 395                 400 


Lys Gln Arg Thr Phe Asp Asn Gly Ser Ile Pro His Gln Ile His Leu 
                405                 410                 415     


Gly Glu Leu His Ala Ile Leu Arg Arg Gln Glu Asp Phe Tyr Pro Phe 
            420                 425                 430         


Leu Lys Asp Asn Arg Glu Lys Ile Glu Lys Ile Leu Thr Phe Arg Ile 
        435                 440                 445             


Pro Tyr Tyr Val Gly Pro Leu Ala Arg Gly Asn Ser Arg Phe Ala Trp 
    450                 455                 460                 


Met Thr Arg Lys Ser Glu Glu Thr Ile Thr Pro Trp Asn Phe Glu Glu 
465                 470                 475                 480 


Val Val Asp Lys Gly Ala Ser Ala Gln Ser Phe Ile Glu Arg Met Thr 
                485                 490                 495     


Asn Phe Asp Lys Asn Leu Pro Asn Glu Lys Val Leu Pro Lys His Ser 
            500                 505                 510         


Leu Leu Tyr Glu Tyr Phe Thr Val Tyr Asn Glu Leu Thr Lys Val Lys 
        515                 520                 525             


Tyr Val Thr Glu Gly Met Arg Lys Pro Ala Phe Leu Ser Gly Glu Gln 
    530                 535                 540                 


Lys Lys Ala Ile Val Asp Leu Leu Phe Lys Thr Asn Arg Lys Val Thr 
545                 550                 555                 560 


Val Lys Gln Leu Lys Glu Asp Tyr Phe Lys Lys Ile Glu Cys Phe Asp 
                565                 570                 575     


Ser Val Glu Ile Ser Gly Val Glu Asp Arg Phe Asn Ala Ser Leu Gly 
            580                 585                 590         


Thr Tyr His Asp Leu Leu Lys Ile Ile Lys Asp Lys Asp Phe Leu Asp 
        595                 600                 605             


Asn Glu Glu Asn Glu Asp Ile Leu Glu Asp Ile Val Leu Thr Leu Thr 
    610                 615                 620                 


Leu Phe Glu Asp Arg Glu Met Ile Glu Glu Arg Leu Lys Thr Tyr Ala 
625                 630                 635                 640 


His Leu Phe Asp Asp Lys Val Met Lys Gln Leu Lys Arg Arg Arg Tyr 
                645                 650                 655     


Thr Gly Trp Gly Arg Leu Ser Arg Lys Leu Ile Asn Gly Ile Arg Asp 
            660                 665                 670         


Lys Gln Ser Gly Lys Thr Ile Leu Asp Phe Leu Lys Ser Asp Gly Phe 
        675                 680                 685             


Ala Asn Arg Asn Phe Met Gln Leu Ile His Asp Asp Ser Leu Thr Phe 
    690                 695                 700                 


Lys Glu Asp Ile Gln Lys Ala Gln Val Ser Gly Gln Gly Asp Ser Leu 
705                 710                 715                 720 


His Glu His Ile Ala Asn Leu Ala Gly Ser Pro Ala Ile Lys Lys Gly 
                725                 730                 735     


Ile Leu Gln Thr Val Lys Val Val Asp Glu Leu Val Lys Val Met Gly 
            740                 745                 750         


Arg His Lys Pro Glu Asn Ile Val Ile Glu Met Ala Arg Glu Asn Gln 
        755                 760                 765             


Thr Thr Gln Lys Gly Gln Lys Asn Ser Arg Glu Arg Met Lys Arg Ile 
    770                 775                 780                 


Glu Glu Gly Ile Lys Glu Leu Gly Ser Gln Ile Leu Lys Glu His Pro 
785                 790                 795                 800 


Val Glu Asn Thr Gln Leu Gln Asn Glu Lys Leu Tyr Leu Tyr Tyr Leu 
                805                 810                 815     


Gln Asn Gly Arg Asp Met Tyr Val Asp Gln Glu Leu Asp Ile Asn Arg 
            820                 825                 830         


Leu Ser Asp Tyr Asp Val Asp His Ile Val Pro Gln Ser Phe Leu Lys 
        835                 840                 845             


Asp Asp Ser Ile Asp Asn Lys Val Leu Thr Arg Ser Asp Lys Asn Arg 
    850                 855                 860                 


Gly Lys Ser Asp Asn Val Pro Ser Glu Glu Val Val Lys Lys Met Lys 
865                 870                 875                 880 


Asn Tyr Trp Arg Gln Leu Leu Asn Ala Lys Leu Ile Thr Gln Arg Lys 
                885                 890                 895     


Phe Asp Asn Leu Thr Lys Ala Glu Arg Gly Gly Leu Ser Glu Leu Asp 
            900                 905                 910         


Lys Ala Gly Phe Ile Lys Arg Gln Leu Val Glu Thr Arg Gln Ile Thr 
        915                 920                 925             


Lys His Val Ala Gln Ile Leu Asp Ser Arg Met Asn Thr Lys Tyr Asp 
    930                 935                 940                 


Glu Asn Asp Lys Leu Ile Arg Glu Val Lys Val Ile Thr Leu Lys Ser 
945                 950                 955                 960 


Lys Leu Val Ser Asp Phe Arg Lys Asp Phe Gln Phe Tyr Lys Val Arg 
                965                 970                 975     


Glu Ile Asn Asn Tyr His His Ala His Asp Ala Tyr Leu Asn Ala Val 
            980                 985                 990         


Val Gly Thr Ala Leu Ile Lys Lys  Tyr Pro Lys Leu Glu  Ser Glu Phe 
        995                 1000                 1005             


Val Tyr  Gly Asp Tyr Lys Val  Tyr Asp Val Arg Lys  Met Ile Ala 
    1010                 1015                 1020             


Lys Ser  Glu Gln Glu Ile Gly  Lys Ala Thr Ala Lys  Tyr Phe Phe 
    1025                 1030                 1035             


Tyr Ser  Asn Ile Met Asn Phe  Phe Lys Thr Glu Ile  Thr Leu Ala 
    1040                 1045                 1050             


Asn Gly  Glu Ile Arg Lys Arg  Pro Leu Ile Glu Thr  Asn Gly Glu 
    1055                 1060                 1065             


Thr Gly  Glu Ile Val Trp Asp  Lys Gly Arg Asp Phe  Ala Thr Val 
    1070                 1075                 1080             


Arg Lys  Val Leu Ser Met Pro  Gln Val Asn Ile Val  Lys Lys Thr 
    1085                 1090                 1095             


Glu Val  Gln Thr Gly Gly Phe  Ser Lys Glu Ser Ile  Leu Pro Lys 
    1100                 1105                 1110             


Arg Asn  Ser Asp Lys Leu Ile  Ala Arg Lys Lys Asp  Trp Asp Pro 
    1115                 1120                 1125             


Lys Lys  Tyr Gly Gly Phe Asp  Ser Pro Thr Val Ala  Tyr Ser Val 
    1130                 1135                 1140             


Leu Val  Val Ala Lys Val Glu  Lys Gly Lys Ser Lys  Lys Leu Lys 
    1145                 1150                 1155             


Ser Val  Lys Glu Leu Leu Gly  Ile Thr Ile Met Glu  Arg Ser Ser 
    1160                 1165                 1170             


Phe Glu  Lys Asn Pro Ile Asp  Phe Leu Glu Ala Lys  Gly Tyr Lys 
    1175                 1180                 1185             


Glu Val  Lys Lys Asp Leu Ile  Ile Lys Leu Pro Lys  Tyr Ser Leu 
    1190                 1195                 1200             


Phe Glu  Leu Glu Asn Gly Arg  Lys Arg Met Leu Ala  Ser Ala Gly 
    1205                 1210                 1215             


Glu Leu  Gln Lys Gly Asn Glu  Leu Ala Leu Pro Ser  Lys Tyr Val 
    1220                 1225                 1230             


Asn Phe  Leu Tyr Leu Ala Ser  His Tyr Glu Lys Leu  Lys Gly Ser 
    1235                 1240                 1245             


Pro Glu  Asp Asn Glu Gln Lys  Gln Leu Phe Val Glu  Gln His Lys 
    1250                 1255                 1260             


His Tyr  Leu Asp Glu Ile Ile  Glu Gln Ile Ser Glu  Phe Ser Lys 
    1265                 1270                 1275             


Arg Val  Ile Leu Ala Asp Ala  Asn Leu Asp Lys Val  Leu Ser Ala 
    1280                 1285                 1290             


Tyr Asn  Lys His Arg Asp Lys  Pro Ile Arg Glu Gln  Ala Glu Asn 
    1295                 1300                 1305             


Ile Ile  His Leu Phe Thr Leu  Thr Asn Leu Gly Ala  Pro Ala Ala 
    1310                 1315                 1320             


Phe Lys  Tyr Phe Asp Thr Thr  Ile Asp Arg Lys Arg  Tyr Thr Ser 
    1325                 1330                 1335             


Thr Lys  Glu Val Leu Asp Ala  Thr Leu Ile His Gln  Ser Ile Thr 
    1340                 1345                 1350             


Gly Leu  Tyr Glu Thr Arg Ile  Asp Leu Ser Gln Leu  Gly Gly Asp 
    1355                 1360                 1365             


Gly Gly  Gly Ser Pro Lys Lys  Lys Arg Lys Val Ser  Glu Ser Ala 
    1370                 1375                 1380             


Thr Pro  Glu Ser Val Ser Gly  Trp Arg Leu Phe Lys  Lys Ile Ser 
    1385                 1390                 1395             


<210> 6
<211> 1556
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      polynucleotide

<400> 6
gagggccgcg gcagcctgct gacctgcggc gacgtggagg agaatcccgg ccccatggtg       60

agcaagggcg aggagctgtt caccggggtg gtgcccatcc tggtcgagct ggacggcgac      120

gtaaacggcc acaagttcag cgtgtccggc gagggcgagg gcgatgccac ctacggcaag      180

ctgaccctga agttcatctg caccaccggc aagctgcccg tgccctggcc caccctcgtg      240

accaccctga cctacggcgt gcagtgcttc agccgctacc ccgaccacat gaagcagcac      300

gacttcttca agtccgccat gcccgaaggc tacgtccagg agcgcaccat cttcttcaag      360

gacgacggca actacaagac ccgcgccgag gtgaagttcg agggcgacac cctggtgaac      420

cgcatcgagc tgaagggcat cgacttcaag gaggacggca acatcctggg gcacaagctg      480

gagtacaact acaacagcca caacgtctat atcatggccg acaagcagaa gaacggcatc      540

aaggtgaact tcaagatccg ccacaacatc gaggacggca gcgtgcagct cgccgaccac      600

taccagcaga acacccccat cggcgacggc cccgtgctgc tgcccgacaa ccactacctg      660

agcacccagt ccgccctgag caaagacccc aacgagaagc gcgatcacat ggtcctgctg      720

gagttcgtga ccgccgccgg gatcactctc ggcatggacg agctgtacaa gtaacctcga      780

ctgtgccttc tagttgccag ccatctgttg tttgcccctc ccccgtgcct tccttgaccc      840

tggaaggtgc cactcccact gtcctttcct aataaaatga ggaaattgca tcgcattgtc      900

tgagtaggtg tcattctatt ctggggggtg gggtggggca ggacagcaag ggggaggatt      960

gggaagacaa tagcaggcat gctggggatg cggtgggctc tatggcttct gaggcggaaa     1020

gaaccagctg gggctctagg gggtatcccc actagtcgtg taccagctga gagactctaa     1080

atccagtgac aagtctgtct gcctattcac cgattttgat tctcaaacaa atgtgtcaca     1140

aagtaaggat tctgatgtgt atatcacaga caaaactgtg ctagacatga ggtctatgga     1200

cttcaagagc aacagtgctg tggcctggag caacaaatct gactttgcat gtgcaaacgc     1260

cttcaacaac agcattattc cagaagacac cttcttcccc agcccaggta agggcagctt     1320

tggtgccttc gcaggctgtt tccttgcttc aggaatggcc aggttctgcc cagagctctg     1380

gtcaatgatg tctaaaactc ctctgattgg tggtctcggc cttatccatt gccaccaaaa     1440

ccctcttttt actaagaaac agtgagcctt gttctggcag tccagagaat gacacgggaa     1500

aaaagcagat gaagagaagg tggcaggaga gggcacgtgg cccagcctca gtctct         1556


<210> 7
<211> 720
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      polynucleotide

<400> 7
atggtgagca agggcgagga gctgttcacc ggggtggtgc ccatcctggt cgagctggac       60

ggcgacgtaa acggccacaa gttcagcgtg tccggcgagg gcgagggcga tgccacctac      120

ggcaagctga ccctgaagtt catctgcacc accggcaagc tgcccgtgcc ctggcccacc      180

ctcgtgacca ccctgaccta cggcgtgcag tgcttcagcc gctaccccga ccacatgaag      240

cagcacgact tcttcaagtc cgccatgccc gaaggctacg tccaggagcg caccatcttc      300

ttcaaggacg acggcaacta caagacccgc gccgaggtga agttcgaggg cgacaccctg      360

gtgaaccgca tcgagctgaa gggcatcgac ttcaaggagg acggcaacat cctggggcac      420

aagctggagt acaactacaa cagccacaac gtctatatca tggccgacaa gcagaagaac      480

ggcatcaagg tgaacttcaa gatccgccac aacatcgagg acggcagcgt gcagctcgcc      540

gaccactacc agcagaacac ccccatcggc gacggccccg tgctgctgcc cgacaaccac      600

tacctgagca cccagtccgc cctgagcaaa gaccccaacg agaagcgcga tcacatggtc      660

ctgctggagt tcgtgaccgc cgccgggatc actctcggca tggacgagct gtacaagtaa      720


<210> 8
<211> 272
<212> PRT
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      polypeptide

<400> 8
Met Glu Thr Leu Leu Lys Val Leu Ser Gly Thr Leu Leu Trp Gln Leu 
1               5                   10                  15      


Thr Trp Val Arg Ser Gln Gln Pro Val Gln Ser Pro Gln Ala Val Ile 
            20                  25                  30          


Leu Arg Glu Gly Glu Asp Ala Val Ile Asn Cys Ser Ser Ser Lys Ala 
        35                  40                  45              


Leu Tyr Ser Val His Trp Tyr Arg Gln Lys His Gly Glu Ala Pro Val 
    50                  55                  60                  


Phe Leu Met Ile Leu Leu Lys Gly Gly Glu Gln Lys Gly His Glu Lys 
65                  70                  75                  80  


Ile Ser Ala Ser Phe Asn Glu Lys Lys Gln Gln Ser Ser Leu Tyr Leu 
                85                  90                  95      


Thr Ala Ser Gln Leu Ser Tyr Ser Gly Thr Tyr Phe Cys Gly Thr Ala 
            100                 105                 110         


Trp Ile Asn Asp Tyr Lys Leu Ser Phe Gly Ala Gly Thr Thr Val Thr 
        115                 120                 125             


Val Arg Ala Asn Ile Gln Asn Pro Asp Pro Ala Val Tyr Gln Leu Arg 
    130                 135                 140                 


Asp Ser Lys Ser Ser Asp Lys Ser Val Cys Leu Phe Thr Asp Phe Asp 
145                 150                 155                 160 


Ser Gln Thr Asn Val Ser Gln Ser Lys Asp Ser Asp Val Tyr Ile Thr 
                165                 170                 175     


Asp Lys Thr Val Leu Asp Met Arg Ser Met Asp Phe Lys Ser Asn Ser 
            180                 185                 190         


Ala Val Ala Trp Ser Asn Lys Ser Asp Phe Ala Cys Ala Asn Ala Phe 
        195                 200                 205             


Asn Asn Ser Ile Ile Pro Glu Asp Thr Phe Phe Pro Ser Pro Glu Ser 
    210                 215                 220                 


Ser Cys Asp Val Lys Leu Val Glu Lys Ser Phe Glu Thr Asp Thr Asn 
225                 230                 235                 240 


Leu Asn Phe Gln Asn Leu Ser Val Ile Gly Phe Arg Ile Leu Leu Leu 
                245                 250                 255     


Lys Val Ala Gly Phe Asn Leu Leu Met Thr Leu Arg Leu Trp Ser Ser 
            260                 265                 270         


<210> 9
<211> 720
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      polynucleotide

<400> 9
atggtgagca agggcgagga gctgttcacc ggggtggtgc ccatcctggt cgagctggac       60

ggcgacgtaa acggccacaa gttcagcgtg tccggcgagg gcgagggcga tgccacctac      120

ggcaagctga ccctgaagtt catctgcacc accggcaagc tgcccgtgcc ctggcccacc      180

ctcgtgacca ccctgaccta cggcgtgcag tgcttcagcc gctaccccga ccacatgaag      240

cagcacgact tcttcaagtc cgccatgccc gaaggctacg tccaggagcg caccatcttc      300

ttcaaggacg acggcaacta caagacccgc gccgaggtga agttcgaggg cgacaccctg      360

gtgaaccgca tcgagctgaa gggcatcgac ttcaaggagg acggcaacat cctggggcac      420

aagctggagt acaactacaa cagccacaac gtctatatca tggccgacaa gcagaagaac      480

ggcatcaagg tgaacttcaa gatccgccac aacatcgagg acggcagcgt gcagctcgcc      540

gaccactacc agcagaacac ccccatcggc gacggccccg tgctgctgcc cgacaaccac      600

tacctgagca cccagtccgc cctgagcaaa gaccccaacg agaagcgcga tcacatggtc      660

ctgctggagt tcgtgaccgc cgccgggatc actctcggca tggacgagct gtacaagtaa      720


<210> 10
<211> 100
<212> RNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      polynucleotide

<400> 10
cucucagcug guacacggca guuuuagagc uagaaauagc aaguuaaaau aaggcuaguc       60

cguuaucaac uugaaaaagu ggcaccgagu cggugcuuuu                            100


<210> 11
<211> 100
<212> RNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      polynucleotide

<400> 11
ggccucggcg cugacgaucu guuuuagagc uagaaauagc aaguuaaaau aaggcuaguc       60

cguuaucaac uugaaaaagu ggcaccgagu cggugcuuuu                            100


<210> 12
<211> 100
<212> RNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      polynucleotide

<400> 12
cccccggacg guucaagcaa guuuuagagc uagaaauagc aaguuaaaau aaggcuaguc       60

cguuaucaac uugaaaaagu ggcaccgagu cggugcuuuu                            100


<210> 13
<211> 100
<212> RNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      polynucleotide

<400> 13
acagcgacgc cgcgagccag guuuuagagc uagaaauagc aaguuaaaau aaggcuaguc       60

cguuaucaac uugaaaaagu ggcaccgagu cggugcuuuu                            100


<210> 14
<211> 4607
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      polynucleotide

<400> 14
ttggccactc cctctctgcg cgctcgctcg ctcactgagg ccgggcgacc aaaggtcgcc       60

cgacgcccgg gctttgcccg ggcggcctca gtgagcgagc gagcgcgcag agagggagtg      120

gccaactcca tcactagggg ttcctagatc ttgccaacat accataaacc tcccattctg      180

ctaatgccca gcctaagttg gggagaccac tccagattcc aagatgtaca gtttgctttg      240

ctgggccttt ttcccatgcc tgcctttact ctgccagagt tatattgctg gggttttgaa      300

gaagatccta ttaaataaaa gaataagcag tattattaag tagccctgca tttcaggttt      360

ccttgagtgg caggccaggc ctggccgtga acgttcactg aaatcatggc ctcttggcca      420

agattgatag cttgtgcctg tccctgagtc ccagtccatc acgagcagct ggtttctaag      480

atgctatttc ccgtataaag catgagaccg tgacttgcca gccccacaga gccccgccct      540

tgtccatcac tggcatctgg actccagcct gggttggggc aaagagggaa atgagatcat      600

gtcctaaccc tgatcctctt gtcccacaga tatccagaac cctgaccctg cggctccggt      660

gcccgtcagt gggcagagcg cacatcgccc acagtccccg agaagttggg gggaggggtc      720

ggcaattgaa ccggtgccta gagaaggtgg cgcggggtaa actgggaaag tgatgtcgtg      780

tactggctcc gcctttttcc cgagggtggg ggagaaccgt atataagtgc agtagtcgcc      840

gtgaacgttc tttttcgcaa cgggtttgcc gccagaacac aggtaagtgc cgtgtgtggt      900

tcccgcgggc ctggcctctt tacgggttat ggcccttgcg tgccttgaat tacttccacg      960

cccctggctg cagtacgtga ttcttgatcc cgagcttcgg gttggaagtg ggtgggagag     1020

ttcgaggcct tgcgcttaag gagccccttc gcctcgtgct tgagttgagg cctggcttgg     1080

gcgctggggc cgccgcgtgc gaatctggtg gcaccttcgc gcctgtctcg ctgctttcga     1140

taagtctcta gccatttaaa atttttgatg acctgctgcg acgctttttt tctggcaaga     1200

tagtcttgta aatgcgggcc aagatgtgca cactggtatt tcggtttttg gggccgcggg     1260

cggcgacggg gcccgtgcgt cccagcgcac atgttcggcg aggcggggcc tgcgagcgcg     1320

gccaccgaga atcggacggg ggtagtctca agctggccgg cctgctctgg tgcctggcct     1380

cgcgccgccg tgtatcgccc cgccctgggc ggcaaggctg gcccggtcgg caccagttgc     1440

gtgagcggaa agatggccgc ttcccggccc tgctgcaggg agctcaaaat ggaggacgcg     1500

gcgctcggga gagcgggcgg gtgagtcacc cacacaaagg aaaagggcct ttccgtcctc     1560

agccgtcgct tcatgtgact ccacggagta ccgggcgccg tccaggcacc tcgattagtt     1620

ctcgagcttt tggagtacgt cgtctttagg ttggggggag gggttttatg cgatggagtt     1680

tccccacact gagtgggtgg agactgaagt taggccagct tggcacttga tgtaattctc     1740

cttggaattt gccctttttg agtttggatc ttggttcatt ctcaagcctc agacagtggt     1800

tcaaagtttt tttcttccat ttcaggtgtc gtgatgcggc cgccaccatg ggatcttgga     1860

cactgtgttg cgtgtccctg tgcatcctgg tggccaagca cacagatgcc ggcgtgatcc     1920

agtctcctag acacgaagtg accgagatgg gccaagaagt gaccctgcgc tgcaagccta     1980

tcagcggcca cgattacctg ttctggtaca gacagaccat gatgagaggc ctggaactgc     2040

tgatctactt caacaacaac gtgcccatcg acgacagcgg catgcccgag gatagattca     2100

gcgccaagat gcccaacgcc agcttcagca ccctgaagat ccagcctagc gagcccagag     2160

atagcgccgt gtacttctgc gccagcagaa agacaggcgg ctacagcaat cagccccagc     2220

actttggaga tggcacccgg ctgagcatcc tggaagatct gaagaacgtg ttcccacctg     2280

aggtggccgt gttcgagcct tctgaggccg agatcagcca cacacagaaa gccacactcg     2340

tgtgtctggc caccggcttc tatcccgatc acgtggaact gtcttggtgg gtcaacggca     2400

aagaggtgca cagcggcgtc agcaccgatc ctcagcctct gaaagagcag cccgctctga     2460

acgacagcag atactgcctg agcagcagac tgagagtgtc cgccaccttc tggcagaacc     2520

ccagaaacca cttcagatgc caggtgcagt tctacggcct gagcgagaac gatgagtgga     2580

cccaggatag agccaagcct gtgacacaga tcgtgtctgc cgaagcctgg ggcagagccg     2640

attgtggctt taccagcgag agctaccagc agggcgtgct gtctgccaca atcctgtacg     2700

agatcctgct gggcaaagcc actctgtacg ccgtgctggt gtctgccctg gtgctgatgg     2760

ccatggtcaa gcggaaggat agcaggggcg gctccggtgc cacaaacttc tccctgctca     2820

agcaggccgg agatgtggaa gagaaccctg gccctatgga aaccctgctg aaggtgctga     2880

gcggcacact gctgtggcag ctgacatggg tccgatctca gcagcctgtg cagtctcctc     2940

aggccgtgat tctgagagaa ggcgaggacg ccgtgatcaa ctgcagcagc tctaaggccc     3000

tgtacagcgt gcactggtac agacagaagc acggcgaggc ccctgtgttc ctgatgatcc     3060

tgctgaaagg cggcgagcag aagggccacg agaagatcag cgccagcttc aacgagaaga     3120

agcagcagtc cagcctgtac ctgacagcca gccagctgag ctacagcggc acctactttt     3180

gtggcaccgc ctggatcaac gactacaagc tgtctttcgg agccggcacc acagtgacag     3240

tgcgggccaa tattcagaac cccgatcctg ccgtgtacca gctgagagac agcaagagca     3300

gcgacaagag cgtgtgcctg ttcaccgact tcgacagcca gaccaacgtg tcccagagca     3360

aggacagcga cgtgtacatc accgataaga ctgtgctgga catgcggagc atggacttca     3420

agagcaacag cgccgtggcc tggtccaaca agagcgattt cgcctgcgcc aacgccttca     3480

acaacagcat tatccccgag gacacattct tcccaagtcc tgagagcagc tgcgacgtga     3540

agctggtgga aaagagcttc gagacagaca ccaacctgaa cttccagaac ctgagcgtga     3600

tcggcttcag aatcctgctg ctcaaggtgg ccggcttcaa cctgctgatg accctgagac     3660

tgtggtccag ctaacctcga ctgtgccttc tagttgccag ccatctgttg tttgcccctc     3720

ccccgtgcct tccttgaccc tggaaggtgc cactcccact gtcctttcct aataaaatga     3780

ggaaattgca tcgcattgtc tgagtaggtg tcattctatt ctggggggtg gggtggggca     3840

ggacagcaag ggggaggatt gggaagacaa tagcaggcat gctggggatg cggtgggctc     3900

tatggcttct gaggcggaaa gaaccagctg gggctctagg gggtatcccc actagtcgtg     3960

taccagctga gagactctaa atccagtgac aagtctgtct gcctattcac cgattttgat     4020

tctcaaacaa atgtgtcaca aagtaaggat tctgatgtgt atatcacaga caaaactgtg     4080

ctagacatga ggtctatgga cttcaagagc aacagtgctg tggcctggag caacaaatct     4140

gactttgcat gtgcaaacgc cttcaacaac agcattattc cagaagacac cttcttcccc     4200

agcccaggta agggcagctt tggtgccttc gcaggctgtt tccttgcttc aggaatggcc     4260

aggttctgcc cagagctctg gtcaatgatg tctaaaactc ctctgattgg tggtctcggc     4320

cttatccatt gccaccaaaa ccctcttttt actaagaaac agtgagcctt gttctggcag     4380

tccagagaat gacacgggaa aaaagcagat gaagagaagg tggcaggaga gggcacgtgg     4440

cccagcctca gtctctagat ctaggaaccc ctagtgatgg agttggccac tccctctctg     4500

cgcgctcgct cgctcactga ggccgcccgg gcaaagcccg ggcgtcgggc gacctttggt     4560

cgcccggcct cagtgagcga gcgagcgcgc agagagggag tggccaa                   4607


<210> 15
<211> 100
<212> RNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      polynucleotide

<400> 15
ccaauaucag gagacuagga guuuuagagc uagaaauagc aaguuaaaau aaggcuaguc       60

cguuaucaac uugaaaaagu ggcaccgagu cggugcuuuu                            100


<210> 16
<211> 254
<212> PRT
<213> Homo sapiens

<400> 16
Met Glu Tyr Ala Ser Asp Ala Ser Leu Asp Pro Glu Ala Pro Trp Pro 
1               5                   10                  15      


Pro Ala Pro Arg Ala Arg Ala Cys Arg Val Leu Pro Trp Ala Leu Val 
            20                  25                  30          


Ala Gly Leu Leu Leu Leu Leu Leu Leu Ala Ala Ala Cys Ala Val Phe 
        35                  40                  45              


Leu Ala Cys Pro Trp Ala Val Ser Gly Ala Arg Ala Ser Pro Gly Ser 
    50                  55                  60                  


Ala Ala Ser Pro Arg Leu Arg Glu Gly Pro Glu Leu Ser Pro Asp Asp 
65                  70                  75                  80  


Pro Ala Gly Leu Leu Asp Leu Arg Gln Gly Met Phe Ala Gln Leu Val 
                85                  90                  95      


Ala Gln Asn Val Leu Leu Ile Asp Gly Pro Leu Ser Trp Tyr Ser Asp 
            100                 105                 110         


Pro Gly Leu Ala Gly Val Ser Leu Thr Gly Gly Leu Ser Tyr Lys Glu 
        115                 120                 125             


Asp Thr Lys Glu Leu Val Val Ala Lys Ala Gly Val Tyr Tyr Val Phe 
    130                 135                 140                 


Phe Gln Leu Glu Leu Arg Arg Val Val Ala Gly Glu Gly Ser Gly Ser 
145                 150                 155                 160 


Val Ser Leu Ala Leu His Leu Gln Pro Leu Arg Ser Ala Ala Gly Ala 
                165                 170                 175     


Ala Ala Leu Ala Leu Thr Val Asp Leu Pro Pro Ala Ser Ser Glu Ala 
            180                 185                 190         


Arg Asn Ser Ala Phe Gly Phe Gln Gly Arg Leu Leu His Leu Ser Ala 
        195                 200                 205             


Gly Gln Arg Leu Gly Val His Leu His Thr Glu Ala Arg Ala Arg His 
    210                 215                 220                 


Ala Trp Gln Leu Thr Gln Gly Ala Thr Val Leu Gly Leu Phe Arg Val 
225                 230                 235                 240 


Thr Pro Glu Ile Pro Ala Gly Leu Pro Ser Pro Arg Ser Glu 
                245                 250                 


<210> 17
<211> 238
<212> PRT
<213> Homo sapiens

<400> 17
Met Asp Trp Thr Trp Ile Leu Phe Leu Val Ala Ala Ala Thr Arg Val 
1               5                   10                  15      


His Ser His Lys Ser Ser Ser Gln Gly Gln Asp Arg His Met Ile Arg 
            20                  25                  30          


Met Arg Gln Leu Ile Asp Ile Val Asp Gln Leu Lys Asn Tyr Val Asn 
        35                  40                  45              


Asp Leu Val Pro Glu Phe Leu Pro Ala Pro Glu Asp Val Glu Thr Asn 
    50                  55                  60                  


Cys Glu Trp Ser Ala Phe Ser Cys Phe Gln Lys Ala Gln Leu Lys Ser 
65                  70                  75                  80  


Ala Asn Thr Gly Asn Asn Glu Arg Ile Ile Asn Val Ser Ile Lys Lys 
                85                  90                  95      


Leu Lys Arg Lys Pro Pro Ser Thr Asn Ala Gly Arg Arg Gln Lys His 
            100                 105                 110         


Arg Leu Thr Cys Pro Ser Cys Asp Ser Tyr Glu Lys Lys Pro Pro Lys 
        115                 120                 125             


Glu Phe Leu Glu Arg Phe Lys Ser Leu Leu Gln Lys Met Ile His Gln 
    130                 135                 140                 


His Leu Ser Ser Arg Thr His Gly Ser Glu Asp Ser Glu Gln Lys Leu 
145                 150                 155                 160 


Ile Ser Glu Glu Asp Leu Thr Thr Thr Pro Ala Pro Arg Pro Pro Thr 
                165                 170                 175     


Pro Ala Pro Thr Ile Ala Ser Gln Pro Leu Ser Leu Arg Pro Glu Ala 
            180                 185                 190         


Cys Arg Pro Ala Ala Gly Gly Ala Val His Thr Arg Gly Leu Asp Phe 
        195                 200                 205             


Ala Cys Asp Phe Trp Val Leu Val Val Val Gly Gly Val Leu Ala Cys 
    210                 215                 220                 


Tyr Ser Leu Leu Val Thr Val Ala Phe Ile Ile Phe Trp Val 
225                 230                 235             


<210> 18
<211> 6
<212> PRT
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      6xHis tag

<400> 18
His His His His His His 
1               5       


<210> 19
<211> 8
<212> PRT
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      8xHis tag

<400> 19
His His His His His His His His 
1               5               


