                         SEQUENCE LISTING

<110>  Spirovant Sciences, Inc.
 
<120>  METHODS AND COMPOSITIONS FOR TREATMENT OF CYSTIC FIBROSIS

<130>  51209-028WO3

<150>  US 63/299,835
<151>  2022-01-14

<150>  US 63/175,507
<151>  2021-04-15

<160>  19    

<170>  PatentIn version 3.5

<210>  1
<211>  107
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Synthetic Construct

<400>  1
gaattcgtgg tgagcgtctg ggcatgtctg ggcatgtctg ggcatgtctg ggcatgtcgg       60

gcattctggg cgtctgggca tgtctgggca tgtctgggca tctcgag                    107


<210>  2
<211>  77
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Synthetic Construct

<400>  2
aacggtgacg tgcacgcgtg ggcggagcca tcacgcaggt tgctatataa gcagagctcg       60

tttagtgaac cgtcaga                                                      77


<210>  3
<211>  17
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Synthetic Construct

<400>  3
gtcgagcccg agagacc                                                      17


<210>  4
<211>  4287
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Synthetic Construct

<400>  4
atgcagaggt cgcctctgga aaaggccagc gttgtctcca aacttttttt cagctggacc       60

agaccaattt tgaggaaagg atacagacag cgcctggaat tgtcagacat ataccaaatc      120

ccttctgttg attctgctga caatctatct gaaaaattgg aaagagaatg ggatagagag      180

ctggcttcaa agaaaaatcc taaactcatt aatgcccttc ggcgatgttt tttctggaga      240

tttatgttct atggaatctt tttatattta ggggaagtca ccaaagcagt acagcctctc      300

ttactgggaa gaatcatagc ttcctatgac ccggataaca aggaggaacg ctctatcgcg      360

atttatctag gcataggctt atgccttctc tttattgtga ggacactgct cctacaccca      420

gccatttttg gccttcatca cattggaatg cagatgagaa tagctatgtt tagtttgatt      480

tataagaaga ctttaaagct gtcaagccgt gttctagata aaataagtat tggacaactt      540

gttagtctcc tttccaacaa cctgaacaaa tttgatgaag gacttgcatt ggcacatttc      600

gtgtggatcg ctcctttgca agtggcactc ctcatggggc taatctggga gttgttacag      660

gcgtctgcct tctgtggact tggtttcctg atagtccttg ccctttttca ggctgggcta      720

gggagaatga tgatgaagta cagagatcag agagctggga agatcagtga aagacttgtg      780

attacctcag aaatgatcga gaacatccaa tctgttaagg catactgctg ggaagaagca      840

atggaaaaaa tgattgaaaa cttaagacaa acagaactga aactgactcg gaaggcagcc      900

tatgtgagat acttcaatag ctcagccttc ttcttctcag ggttctttgt ggtgttttta      960

tctgtgcttc cctatgcact aatcaaagga atcatcctcc ggaaaatatt caccaccatc     1020

tcattctgca ttgttctgcg catggcggtc actcggcaat ttccctgggc tgtacaaaca     1080

tggtatgact ctcttggagc aataaacaaa atacaggatt tcttacaaaa gcaagaatat     1140

aagacattgg aatataactt aacgactaca gaagtagtga tggagaatgt aacagccttc     1200

tgggaggagg gatttgggga attatttgag aaagcaaaac aaaacaataa caatagaaaa     1260

acttctaatg gtgatgacag cctcttcttc agtaatttct cacttcttgg tactcctgtc     1320

ctgaaagata ttaatttcaa gatagaaaga ggacagttgt tggcggttgc tggatccact     1380

ggagcaggca agacttcact tctaatgatg attatgggag aactggagcc ttcagagggt     1440

aaaattaagc acagtggaag aatttcattc tgttctcagt tttcctggat tatgcctggc     1500

accattaaag aaaatatcat ctttggtgtt tcctatgatg aatatagata cagaagcgtc     1560

atcaaagcat gccaactaga agaggacatc tccaagtttg cagagaaaga caatatagtt     1620

cttggagaag gtggaatcac actgagtgga ggtcaacgag caagaatttc tttagcaaga     1680

gcagtataca aagatgctga tttgtattta ttagactctc cttttggata cctagatgtt     1740

ttaacagaaa aagaaatatt tgaaagctgt gtctgtaaac tgatggctaa caaaactagg     1800

attttggtca cttctaaaat ggaacattta aagaaagctg acaaaatatt aattttgcat     1860

gaaggtagca gctattttta tgggacattt tcagaactcc aaaatctaca gccagacttt     1920

agctcaaaac tcatgggatg tgattctttc gaccaattta gtgcagaaag aagaaattca     1980

atcctaactg agaccttaca ccgtttctca ttagaaggag atgctcctgt ctcctggaca     2040

gaaacaaaaa aacaatcttt taaacagact ggagagtttg gggaaaaaag gaagaattct     2100

attctcaatc caatcaactc tacgcttcag gcacgaagga ggcagtctgt cctgaacctg     2160

atgacacact cagttaacca aggtcagaac attcaccgaa agacaacagc atccacacga     2220

aaagtgtcac tggcccctca ggcaaacttg actgaactgg atatatattc aagaaggtta     2280

tctcaagaaa ctggcttgga aataagtgaa gaaattaacg aagaagactt aaaggagtgc     2340

ctttttgatg atatggagag cataccagca gtgactacat ggaacacata ccttcgatat     2400

attactgtcc acaagagctt aatttttgtg ctaatttggt gcttagtaat ttttctggca     2460

gaggtggctg cttctttggt tgtgctgtgg ctccttggaa acactcctct tcaagacaaa     2520

gggaatagta ctcatagtag aaataacagc tatgcagtga ttatcaccag caccagttcg     2580

tattatgtgt tttacattta cgtgggagta gccgacactt tgcttgctat gggattcttc     2640

agaggtctac cactggtgca tactctaatc acagtgtcga aaattttaca ccacaaaatg     2700

ttacattctg ttcttcaagc acctatgtca accctcaaca cgttgaaagc aggtgggatt     2760

cttaatagat tctccaaaga tatagcaatt ttggatgacc ttctgcctct taccatattt     2820

gacttcatcc agttgttatt aattgtgatt ggagctatag cagttgtcgc agttttacaa     2880

ccctacatct ttgttgcaac agtgccagtg atagtggctt ttattatgtt gagagcatat     2940

ttcctccaaa cctcacagca actcaaacaa ctggaatctg aaggcaggag tccaattttc     3000

actcatcttg ttacaagctt aaaaggacta tggacacttc gtgccttcgg acggcagcct     3060

tactttgaaa ctctgttcca caaagctctg aatttacata ctgccaactg gttcttgtac     3120

ctgtcaacac tgcgctggtt ccaaatgaga atagaaatga tttttgtcat cttcttcatt     3180

gctgttacct tcatttccat tttaacaaca ggagaaggag aaggaagagt tggtattatc     3240

ctgactttag ccatgaatat catgagtaca ttgcagtggg ctgtaaactc cagcatagat     3300

gtggatagct tgatgcgatc tgtgagccga gtctttaagt tcattgacat gccaacagaa     3360

ggtaaaccta ccaagtcaac caaaccatac aagaatggcc aactctcgaa agttatgatt     3420

attgagaatt cacacgtgaa gaaagatgac atctggccct cagggggcca aatgactgtc     3480

aaagatctca cagcaaaata cacagaaggt ggaaatgcca tattagagaa catttccttc     3540

tcaataagtc ctggccagag ggtgggcctc ttgggaagaa ctggatcagg gaagagtact     3600

ttgttatcag cttttttgag actactgaac actgaaggag aaatccagat cgatggtgtg     3660

tcttgggatt caataacttt gcaacagtgg aggaaagcct ttggagtgat accacagaaa     3720

gtatttattt tttctggaac atttagaaaa aacttggatc cctatgaaca gtggagtgat     3780

caagaaatat ggaaagttgc agatgaggtt gggctcagat ctgtgataga acagtttcct     3840

gggaagcttg actttgtcct tgtggatggg ggctgtgtcc taagccatgg ccacaagcag     3900

ttgatgtgct tggctagatc tgttctcagt aaggcgaaga tcttgctgct tgatgaaccc     3960

agtgctcatt tggatccagt aacataccaa ataattagaa gaactctaaa acaagcattt     4020

gctgattgca cagtaattct ctgtgaacac aggatagaag caatgctgga atgccaacaa     4080

tttttggtca tagaagagaa caaagtgcgg cagtacgatt ccatccagaa actgctgaac     4140

gagaggagcc tcttccggca agccatcagc ccctccgaca gggtgaagct ctttccccac     4200

cggaactcaa gcaagtgcaa gtctaagccc cagattgctg ctctgaaaga ggagacagaa     4260

gaagaggtgc aagatacaag gctttag                                         4287


<210>  5
<211>  45
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Synthetic Construct

<400>  5
agagcagcat aaatgttgac atgggacatt tgctcatgga attgg                       45


<210>  6
<211>  50
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Synthetic Construct

<400>  6
aataaagagc tcagatgcat cgatcagagt gtgttggttt tttgtgtgta                  50


<210>  7
<211>  4488
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Synthetic Construct

<400>  7
gaattcgtgg tgagcgtctg ggcatgtctg ggcatgtctg ggcatgtctg ggcatgtcgg       60

gcattctggg cgtctgggca tgtctgggca tgtctgggca tctcgagaac ggtgacgtgc      120

acgcgtgggc ggagccatca cgcaggttgc tatataagca gagctcgttt agtgaaccgt      180

cagagtcgag cccgagagac catgcagagg tcgcctctgg aaaaggccag cgttgtctcc      240

aaactttttt tcagctggac cagaccaatt ttgaggaaag gatacagaca gcgcctggaa      300

ttgtcagaca tataccaaat cccttctgtt gattctgctg acaatctatc tgaaaaattg      360

gaaagagaat gggatagaga gctggcttca aagaaaaatc ctaaactcat taatgccctt      420

cggcgatgtt ttttctggag atttatgttc tatggaatct ttttatattt aggggaagtc      480

accaaagcag tacagcctct cttactggga agaatcatag cttcctatga cccggataac      540

aaggaggaac gctctatcgc gatttatcta ggcataggct tatgccttct ctttattgtg      600

aggacactgc tcctacaccc agccattttt ggccttcatc acattggaat gcagatgaga      660

atagctatgt ttagtttgat ttataagaag actttaaagc tgtcaagccg tgttctagat      720

aaaataagta ttggacaact tgttagtctc ctttccaaca acctgaacaa atttgatgaa      780

ggacttgcat tggcacattt cgtgtggatc gctcctttgc aagtggcact cctcatgggg      840

ctaatctggg agttgttaca ggcgtctgcc ttctgtggac ttggtttcct gatagtcctt      900

gccctttttc aggctgggct agggagaatg atgatgaagt acagagatca gagagctggg      960

aagatcagtg aaagacttgt gattacctca gaaatgatcg agaacatcca atctgttaag     1020

gcatactgct gggaagaagc aatggaaaaa atgattgaaa acttaagaca aacagaactg     1080

aaactgactc ggaaggcagc ctatgtgaga tacttcaata gctcagcctt cttcttctca     1140

gggttctttg tggtgttttt atctgtgctt ccctatgcac taatcaaagg aatcatcctc     1200

cggaaaatat tcaccaccat ctcattctgc attgttctgc gcatggcggt cactcggcaa     1260

tttccctggg ctgtacaaac atggtatgac tctcttggag caataaacaa aatacaggat     1320

ttcttacaaa agcaagaata taagacattg gaatataact taacgactac agaagtagtg     1380

atggagaatg taacagcctt ctgggaggag ggatttgggg aattatttga gaaagcaaaa     1440

caaaacaata acaatagaaa aacttctaat ggtgatgaca gcctcttctt cagtaatttc     1500

tcacttcttg gtactcctgt cctgaaagat attaatttca agatagaaag aggacagttg     1560

ttggcggttg ctggatccac tggagcaggc aagacttcac ttctaatgat gattatggga     1620

gaactggagc cttcagaggg taaaattaag cacagtggaa gaatttcatt ctgttctcag     1680

ttttcctgga ttatgcctgg caccattaaa gaaaatatca tctttggtgt ttcctatgat     1740

gaatatagat acagaagcgt catcaaagca tgccaactag aagaggacat ctccaagttt     1800

gcagagaaag acaatatagt tcttggagaa ggtggaatca cactgagtgg aggtcaacga     1860

gcaagaattt ctttagcaag agcagtatac aaagatgctg atttgtattt attagactct     1920

ccttttggat acctagatgt tttaacagaa aaagaaatat ttgaaagctg tgtctgtaaa     1980

ctgatggcta acaaaactag gattttggtc acttctaaaa tggaacattt aaagaaagct     2040

gacaaaatat taattttgca tgaaggtagc agctattttt atgggacatt ttcagaactc     2100

caaaatctac agccagactt tagctcaaaa ctcatgggat gtgattcttt cgaccaattt     2160

agtgcagaaa gaagaaattc aatcctaact gagaccttac accgtttctc attagaagga     2220

gatgctcctg tctcctggac agaaacaaaa aaacaatctt ttaaacagac tggagagttt     2280

ggggaaaaaa ggaagaattc tattctcaat ccaatcaact ctacgcttca ggcacgaagg     2340

aggcagtctg tcctgaacct gatgacacac tcagttaacc aaggtcagaa cattcaccga     2400

aagacaacag catccacacg aaaagtgtca ctggcccctc aggcaaactt gactgaactg     2460

gatatatatt caagaaggtt atctcaagaa actggcttgg aaataagtga agaaattaac     2520

gaagaagact taaaggagtg cctttttgat gatatggaga gcataccagc agtgactaca     2580

tggaacacat accttcgata tattactgtc cacaagagct taatttttgt gctaatttgg     2640

tgcttagtaa tttttctggc agaggtggct gcttctttgg ttgtgctgtg gctccttgga     2700

aacactcctc ttcaagacaa agggaatagt actcatagta gaaataacag ctatgcagtg     2760

attatcacca gcaccagttc gtattatgtg ttttacattt acgtgggagt agccgacact     2820

ttgcttgcta tgggattctt cagaggtcta ccactggtgc atactctaat cacagtgtcg     2880

aaaattttac accacaaaat gttacattct gttcttcaag cacctatgtc aaccctcaac     2940

acgttgaaag caggtgggat tcttaataga ttctccaaag atatagcaat tttggatgac     3000

cttctgcctc ttaccatatt tgacttcatc cagttgttat taattgtgat tggagctata     3060

gcagttgtcg cagttttaca accctacatc tttgttgcaa cagtgccagt gatagtggct     3120

tttattatgt tgagagcata tttcctccaa acctcacagc aactcaaaca actggaatct     3180

gaaggcagga gtccaatttt cactcatctt gttacaagct taaaaggact atggacactt     3240

cgtgccttcg gacggcagcc ttactttgaa actctgttcc acaaagctct gaatttacat     3300

actgccaact ggttcttgta cctgtcaaca ctgcgctggt tccaaatgag aatagaaatg     3360

atttttgtca tcttcttcat tgctgttacc ttcatttcca ttttaacaac aggagaagga     3420

gaaggaagag ttggtattat cctgacttta gccatgaata tcatgagtac attgcagtgg     3480

gctgtaaact ccagcataga tgtggatagc ttgatgcgat ctgtgagccg agtctttaag     3540

ttcattgaca tgccaacaga aggtaaacct accaagtcaa ccaaaccata caagaatggc     3600

caactctcga aagttatgat tattgagaat tcacacgtga agaaagatga catctggccc     3660

tcagggggcc aaatgactgt caaagatctc acagcaaaat acacagaagg tggaaatgcc     3720

atattagaga acatttcctt ctcaataagt cctggccaga gggtgggcct cttgggaaga     3780

actggatcag ggaagagtac tttgttatca gcttttttga gactactgaa cactgaagga     3840

gaaatccaga tcgatggtgt gtcttgggat tcaataactt tgcaacagtg gaggaaagcc     3900

tttggagtga taccacagaa agtatttatt ttttctggaa catttagaaa aaacttggat     3960

ccctatgaac agtggagtga tcaagaaata tggaaagttg cagatgaggt tgggctcaga     4020

tctgtgatag aacagtttcc tgggaagctt gactttgtcc ttgtggatgg gggctgtgtc     4080

ctaagccatg gccacaagca gttgatgtgc ttggctagat ctgttctcag taaggcgaag     4140

atcttgctgc ttgatgaacc cagtgctcat ttggatccag taacatacca aataattaga     4200

agaactctaa aacaagcatt tgctgattgc acagtaattc tctgtgaaca caggatagaa     4260

gcaatgctgg aatgccaaca atttttggtc atagaagaga acaaagtgcg gcagtacgat     4320

tccatccaga aactgctgaa cgagaggagc ctcttccggc aagccatcag cccctccgac     4380

agggtgaagc tctttcccca ccggaactca agcaagtgca agtctaagcc ccagattgct     4440

gctctgaaag aggagacaga agaagaggtg caagatacaa ggctttag                  4488


<210>  8
<211>  4533
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Synthetic Construct

<400>  8
gaattcgtgg tgagcgtctg ggcatgtctg ggcatgtctg ggcatgtctg ggcatgtcgg       60

gcattctggg cgtctgggca tgtctgggca tgtctgggca tctcgagaac ggtgacgtgc      120

acgcgtgggc ggagccatca cgcaggttgc tatataagca gagctcgttt agtgaaccgt      180

cagagtcgag cccgagagac catgcagagg tcgcctctgg aaaaggccag cgttgtctcc      240

aaactttttt tcagctggac cagaccaatt ttgaggaaag gatacagaca gcgcctggaa      300

ttgtcagaca tataccaaat cccttctgtt gattctgctg acaatctatc tgaaaaattg      360

gaaagagaat gggatagaga gctggcttca aagaaaaatc ctaaactcat taatgccctt      420

cggcgatgtt ttttctggag atttatgttc tatggaatct ttttatattt aggggaagtc      480

accaaagcag tacagcctct cttactggga agaatcatag cttcctatga cccggataac      540

aaggaggaac gctctatcgc gatttatcta ggcataggct tatgccttct ctttattgtg      600

aggacactgc tcctacaccc agccattttt ggccttcatc acattggaat gcagatgaga      660

atagctatgt ttagtttgat ttataagaag actttaaagc tgtcaagccg tgttctagat      720

aaaataagta ttggacaact tgttagtctc ctttccaaca acctgaacaa atttgatgaa      780

ggacttgcat tggcacattt cgtgtggatc gctcctttgc aagtggcact cctcatgggg      840

ctaatctggg agttgttaca ggcgtctgcc ttctgtggac ttggtttcct gatagtcctt      900

gccctttttc aggctgggct agggagaatg atgatgaagt acagagatca gagagctggg      960

aagatcagtg aaagacttgt gattacctca gaaatgatcg agaacatcca atctgttaag     1020

gcatactgct gggaagaagc aatggaaaaa atgattgaaa acttaagaca aacagaactg     1080

aaactgactc ggaaggcagc ctatgtgaga tacttcaata gctcagcctt cttcttctca     1140

gggttctttg tggtgttttt atctgtgctt ccctatgcac taatcaaagg aatcatcctc     1200

cggaaaatat tcaccaccat ctcattctgc attgttctgc gcatggcggt cactcggcaa     1260

tttccctggg ctgtacaaac atggtatgac tctcttggag caataaacaa aatacaggat     1320

ttcttacaaa agcaagaata taagacattg gaatataact taacgactac agaagtagtg     1380

atggagaatg taacagcctt ctgggaggag ggatttgggg aattatttga gaaagcaaaa     1440

caaaacaata acaatagaaa aacttctaat ggtgatgaca gcctcttctt cagtaatttc     1500

tcacttcttg gtactcctgt cctgaaagat attaatttca agatagaaag aggacagttg     1560

ttggcggttg ctggatccac tggagcaggc aagacttcac ttctaatgat gattatggga     1620

gaactggagc cttcagaggg taaaattaag cacagtggaa gaatttcatt ctgttctcag     1680

ttttcctgga ttatgcctgg caccattaaa gaaaatatca tctttggtgt ttcctatgat     1740

gaatatagat acagaagcgt catcaaagca tgccaactag aagaggacat ctccaagttt     1800

gcagagaaag acaatatagt tcttggagaa ggtggaatca cactgagtgg aggtcaacga     1860

gcaagaattt ctttagcaag agcagtatac aaagatgctg atttgtattt attagactct     1920

ccttttggat acctagatgt tttaacagaa aaagaaatat ttgaaagctg tgtctgtaaa     1980

ctgatggcta acaaaactag gattttggtc acttctaaaa tggaacattt aaagaaagct     2040

gacaaaatat taattttgca tgaaggtagc agctattttt atgggacatt ttcagaactc     2100

caaaatctac agccagactt tagctcaaaa ctcatgggat gtgattcttt cgaccaattt     2160

agtgcagaaa gaagaaattc aatcctaact gagaccttac accgtttctc attagaagga     2220

gatgctcctg tctcctggac agaaacaaaa aaacaatctt ttaaacagac tggagagttt     2280

ggggaaaaaa ggaagaattc tattctcaat ccaatcaact ctacgcttca ggcacgaagg     2340

aggcagtctg tcctgaacct gatgacacac tcagttaacc aaggtcagaa cattcaccga     2400

aagacaacag catccacacg aaaagtgtca ctggcccctc aggcaaactt gactgaactg     2460

gatatatatt caagaaggtt atctcaagaa actggcttgg aaataagtga agaaattaac     2520

gaagaagact taaaggagtg cctttttgat gatatggaga gcataccagc agtgactaca     2580

tggaacacat accttcgata tattactgtc cacaagagct taatttttgt gctaatttgg     2640

tgcttagtaa tttttctggc agaggtggct gcttctttgg ttgtgctgtg gctccttgga     2700

aacactcctc ttcaagacaa agggaatagt actcatagta gaaataacag ctatgcagtg     2760

attatcacca gcaccagttc gtattatgtg ttttacattt acgtgggagt agccgacact     2820

ttgcttgcta tgggattctt cagaggtcta ccactggtgc atactctaat cacagtgtcg     2880

aaaattttac accacaaaat gttacattct gttcttcaag cacctatgtc aaccctcaac     2940

acgttgaaag caggtgggat tcttaataga ttctccaaag atatagcaat tttggatgac     3000

cttctgcctc ttaccatatt tgacttcatc cagttgttat taattgtgat tggagctata     3060

gcagttgtcg cagttttaca accctacatc tttgttgcaa cagtgccagt gatagtggct     3120

tttattatgt tgagagcata tttcctccaa acctcacagc aactcaaaca actggaatct     3180

gaaggcagga gtccaatttt cactcatctt gttacaagct taaaaggact atggacactt     3240

cgtgccttcg gacggcagcc ttactttgaa actctgttcc acaaagctct gaatttacat     3300

actgccaact ggttcttgta cctgtcaaca ctgcgctggt tccaaatgag aatagaaatg     3360

atttttgtca tcttcttcat tgctgttacc ttcatttcca ttttaacaac aggagaagga     3420

gaaggaagag ttggtattat cctgacttta gccatgaata tcatgagtac attgcagtgg     3480

gctgtaaact ccagcataga tgtggatagc ttgatgcgat ctgtgagccg agtctttaag     3540

ttcattgaca tgccaacaga aggtaaacct accaagtcaa ccaaaccata caagaatggc     3600

caactctcga aagttatgat tattgagaat tcacacgtga agaaagatga catctggccc     3660

tcagggggcc aaatgactgt caaagatctc acagcaaaat acacagaagg tggaaatgcc     3720

atattagaga acatttcctt ctcaataagt cctggccaga gggtgggcct cttgggaaga     3780

actggatcag ggaagagtac tttgttatca gcttttttga gactactgaa cactgaagga     3840

gaaatccaga tcgatggtgt gtcttgggat tcaataactt tgcaacagtg gaggaaagcc     3900

tttggagtga taccacagaa agtatttatt ttttctggaa catttagaaa aaacttggat     3960

ccctatgaac agtggagtga tcaagaaata tggaaagttg cagatgaggt tgggctcaga     4020

tctgtgatag aacagtttcc tgggaagctt gactttgtcc ttgtggatgg gggctgtgtc     4080

ctaagccatg gccacaagca gttgatgtgc ttggctagat ctgttctcag taaggcgaag     4140

atcttgctgc ttgatgaacc cagtgctcat ttggatccag taacatacca aataattaga     4200

agaactctaa aacaagcatt tgctgattgc acagtaattc tctgtgaaca caggatagaa     4260

gcaatgctgg aatgccaaca atttttggtc atagaagaga acaaagtgcg gcagtacgat     4320

tccatccaga aactgctgaa cgagaggagc ctcttccggc aagccatcag cccctccgac     4380

agggtgaagc tctttcccca ccggaactca agcaagtgca agtctaagcc ccagattgct     4440

gctctgaaag aggagacaga agaagaggtg caagatacaa ggctttagag agcagcataa     4500

atgttgacat gggacatttg ctcatggaat tgg                                  4533


<210>  9
<211>  145
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Synthetic Construct

<400>  9
ttggccactc cctctctgcg cgctcgctcg ctcactgagg ccgggcgacc aaaggtcgcc       60

cgacgcccgg gctttgcccg ggcggcctca gtgagcgagc gagcgcgcag agagggagtg      120

gccaactcca tcactagggg ttcct                                            145


<210>  10
<211>  145
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Synthetic Construct

<400>  10
aggaacccct agtgatggag ttggccactc cctctctgcg cgctcgctcg ctcactgagg       60

ccgcccgggc aaagcccggg cgtcgggcga cctttggtcg cccggcctca gtgagcgagc      120

gagcgcgcag agagggagtg gccaa                                            145


<210>  11
<211>  4890
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Synthetic Construct

<400>  11
ttggccactc cctctctgcg cgctcgctcg ctcactgagg ccgggcgacc aaaggtcgcc       60

cgacgcccgg gctttgcccg ggcggcctca gtgagcgagc gagcgcgcag agagggagtg      120

gccaactcca tcactagggg ttcctcagat ctgaattcgt ggtgagcgtc tgggcatgtc      180

tgggcatgtc tgggcatgtc tgggcatgtc gggcattctg ggcgtctggg catgtctggg      240

catgtctggg catctcgaga acggtgacgt gcacgcgtgg gcggagccat cacgcaggtt      300

gctatataag cagagctcgt ttagtgaacc gtcagagtcg agcccgagag accatgcaga      360

ggtcgcctct ggaaaaggcc agcgttgtct ccaaactttt tttcagctgg accagaccaa      420

ttttgaggaa aggatacaga cagcgcctgg aattgtcaga catataccaa atcccttctg      480

ttgattctgc tgacaatcta tctgaaaaat tggaaagaga atgggataga gagctggctt      540

caaagaaaaa tcctaaactc attaatgccc ttcggcgatg ttttttctgg agatttatgt      600

tctatggaat ctttttatat ttaggggaag tcaccaaagc agtacagcct ctcttactgg      660

gaagaatcat agcttcctat gacccggata acaaggagga acgctctatc gcgatttatc      720

taggcatagg cttatgcctt ctctttattg tgaggacact gctcctacac ccagccattt      780

ttggccttca tcacattgga atgcagatga gaatagctat gtttagtttg atttataaga      840

agactttaaa gctgtcaagc cgtgttctag ataaaataag tattggacaa cttgttagtc      900

tcctttccaa caacctgaac aaatttgatg aaggacttgc attggcacat ttcgtgtgga      960

tcgctccttt gcaagtggca ctcctcatgg ggctaatctg ggagttgtta caggcgtctg     1020

ccttctgtgg acttggtttc ctgatagtcc ttgccctttt tcaggctggg ctagggagaa     1080

tgatgatgaa gtacagagat cagagagctg ggaagatcag tgaaagactt gtgattacct     1140

cagaaatgat cgagaacatc caatctgtta aggcatactg ctgggaagaa gcaatggaaa     1200

aaatgattga aaacttaaga caaacagaac tgaaactgac tcggaaggca gcctatgtga     1260

gatacttcaa tagctcagcc ttcttcttct cagggttctt tgtggtgttt ttatctgtgc     1320

ttccctatgc actaatcaaa ggaatcatcc tccggaaaat attcaccacc atctcattct     1380

gcattgttct gcgcatggcg gtcactcggc aatttccctg ggctgtacaa acatggtatg     1440

actctcttgg agcaataaac aaaatacagg atttcttaca aaagcaagaa tataagacat     1500

tggaatataa cttaacgact acagaagtag tgatggagaa tgtaacagcc ttctgggagg     1560

agggatttgg ggaattattt gagaaagcaa aacaaaacaa taacaataga aaaacttcta     1620

atggtgatga cagcctcttc ttcagtaatt tctcacttct tggtactcct gtcctgaaag     1680

atattaattt caagatagaa agaggacagt tgttggcggt tgctggatcc actggagcag     1740

gcaagacttc acttctaatg atgattatgg gagaactgga gccttcagag ggtaaaatta     1800

agcacagtgg aagaatttca ttctgttctc agttttcctg gattatgcct ggcaccatta     1860

aagaaaatat catctttggt gtttcctatg atgaatatag atacagaagc gtcatcaaag     1920

catgccaact agaagaggac atctccaagt ttgcagagaa agacaatata gttcttggag     1980

aaggtggaat cacactgagt ggaggtcaac gagcaagaat ttctttagca agagcagtat     2040

acaaagatgc tgatttgtat ttattagact ctccttttgg atacctagat gttttaacag     2100

aaaaagaaat atttgaaagc tgtgtctgta aactgatggc taacaaaact aggattttgg     2160

tcacttctaa aatggaacat ttaaagaaag ctgacaaaat attaattttg catgaaggta     2220

gcagctattt ttatgggaca ttttcagaac tccaaaatct acagccagac tttagctcaa     2280

aactcatggg atgtgattct ttcgaccaat ttagtgcaga aagaagaaat tcaatcctaa     2340

ctgagacctt acaccgtttc tcattagaag gagatgctcc tgtctcctgg acagaaacaa     2400

aaaaacaatc ttttaaacag actggagagt ttggggaaaa aaggaagaat tctattctca     2460

atccaatcaa ctctacgctt caggcacgaa ggaggcagtc tgtcctgaac ctgatgacac     2520

actcagttaa ccaaggtcag aacattcacc gaaagacaac agcatccaca cgaaaagtgt     2580

cactggcccc tcaggcaaac ttgactgaac tggatatata ttcaagaagg ttatctcaag     2640

aaactggctt ggaaataagt gaagaaatta acgaagaaga cttaaaggag tgcctttttg     2700

atgatatgga gagcatacca gcagtgacta catggaacac ataccttcga tatattactg     2760

tccacaagag cttaattttt gtgctaattt ggtgcttagt aatttttctg gcagaggtgg     2820

ctgcttcttt ggttgtgctg tggctccttg gaaacactcc tcttcaagac aaagggaata     2880

gtactcatag tagaaataac agctatgcag tgattatcac cagcaccagt tcgtattatg     2940

tgttttacat ttacgtggga gtagccgaca ctttgcttgc tatgggattc ttcagaggtc     3000

taccactggt gcatactcta atcacagtgt cgaaaatttt acaccacaaa atgttacatt     3060

ctgttcttca agcacctatg tcaaccctca acacgttgaa agcaggtggg attcttaata     3120

gattctccaa agatatagca attttggatg accttctgcc tcttaccata tttgacttca     3180

tccagttgtt attaattgtg attggagcta tagcagttgt cgcagtttta caaccctaca     3240

tctttgttgc aacagtgcca gtgatagtgg cttttattat gttgagagca tatttcctcc     3300

aaacctcaca gcaactcaaa caactggaat ctgaaggcag gagtccaatt ttcactcatc     3360

ttgttacaag cttaaaagga ctatggacac ttcgtgcctt cggacggcag ccttactttg     3420

aaactctgtt ccacaaagct ctgaatttac atactgccaa ctggttcttg tacctgtcaa     3480

cactgcgctg gttccaaatg agaatagaaa tgatttttgt catcttcttc attgctgtta     3540

ccttcatttc cattttaaca acaggagaag gagaaggaag agttggtatt atcctgactt     3600

tagccatgaa tatcatgagt acattgcagt gggctgtaaa ctccagcata gatgtggata     3660

gcttgatgcg atctgtgagc cgagtcttta agttcattga catgccaaca gaaggtaaac     3720

ctaccaagtc aaccaaacca tacaagaatg gccaactctc gaaagttatg attattgaga     3780

attcacacgt gaagaaagat gacatctggc cctcaggggg ccaaatgact gtcaaagatc     3840

tcacagcaaa atacacagaa ggtggaaatg ccatattaga gaacatttcc ttctcaataa     3900

gtcctggcca gagggtgggc ctcttgggaa gaactggatc agggaagagt actttgttat     3960

cagctttttt gagactactg aacactgaag gagaaatcca gatcgatggt gtgtcttggg     4020

attcaataac tttgcaacag tggaggaaag cctttggagt gataccacag aaagtattta     4080

ttttttctgg aacatttaga aaaaacttgg atccctatga acagtggagt gatcaagaaa     4140

tatggaaagt tgcagatgag gttgggctca gatctgtgat agaacagttt cctgggaagc     4200

ttgactttgt ccttgtggat gggggctgtg tcctaagcca tggccacaag cagttgatgt     4260

gcttggctag atctgttctc agtaaggcga agatcttgct gcttgatgaa cccagtgctc     4320

atttggatcc agtaacatac caaataatta gaagaactct aaaacaagca tttgctgatt     4380

gcacagtaat tctctgtgaa cacaggatag aagcaatgct ggaatgccaa caatttttgg     4440

tcatagaaga gaacaaagtg cggcagtacg attccatcca gaaactgctg aacgagagga     4500

gcctcttccg gcaagccatc agcccctccg acagggtgaa gctctttccc caccggaact     4560

caagcaagtg caagtctaag ccccagattg ctgctctgaa agaggagaca gaagaagagg     4620

tgcaagatac aaggctttag agagcagcat aaatgttgac atgggacatt tgctcatgga     4680

attggcaggc ctaataaaga gctcagatgc atcgatcaga gtgtgttggt tttttgtgtg     4740

tactgaggaa cccctagtga tggagttggc cactccctct ctgcgcgctc gctcgctcac     4800

tgaggccgcc cgggcaaagc ccgggcgtcg ggcgaccttt ggtcgcccgg cctcagtgag     4860

cgagcgagcg cgcagagagg gagtggccaa                                      4890


<210>  12
<211>  7767
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Synthetic Construct

<400>  12
ttggccactc cctctctgcg cgctcgctcg ctcactgagg ccgggcgacc aaaggtcgcc       60

cgacgcccgg gctttgcccg ggcggcctca gtgagcgagc gagcgcgcag agagggagtg      120

gccaactcca tcactagggg ttcctcagat ctgaattcgt ggtgagcgtc tgggcatgtc      180

tgggcatgtc tgggcatgtc tgggcatgtc gggcattctg ggcgtctggg catgtctggg      240

catgtctggg catctcgaga acggtgacgt gcacgcgtgg gcggagccat cacgcaggtt      300

gctatataag cagagctcgt ttagtgaacc gtcagagtcg agcccgagag accatgcaga      360

ggtcgcctct ggaaaaggcc agcgttgtct ccaaactttt tttcagctgg accagaccaa      420

ttttgaggaa aggatacaga cagcgcctgg aattgtcaga catataccaa atcccttctg      480

ttgattctgc tgacaatcta tctgaaaaat tggaaagaga atgggataga gagctggctt      540

caaagaaaaa tcctaaactc attaatgccc ttcggcgatg ttttttctgg agatttatgt      600

tctatggaat ctttttatat ttaggggaag tcaccaaagc agtacagcct ctcttactgg      660

gaagaatcat agcttcctat gacccggata acaaggagga acgctctatc gcgatttatc      720

taggcatagg cttatgcctt ctctttattg tgaggacact gctcctacac ccagccattt      780

ttggccttca tcacattgga atgcagatga gaatagctat gtttagtttg atttataaga      840

agactttaaa gctgtcaagc cgtgttctag ataaaataag tattggacaa cttgttagtc      900

tcctttccaa caacctgaac aaatttgatg aaggacttgc attggcacat ttcgtgtgga      960

tcgctccttt gcaagtggca ctcctcatgg ggctaatctg ggagttgtta caggcgtctg     1020

ccttctgtgg acttggtttc ctgatagtcc ttgccctttt tcaggctggg ctagggagaa     1080

tgatgatgaa gtacagagat cagagagctg ggaagatcag tgaaagactt gtgattacct     1140

cagaaatgat cgagaacatc caatctgtta aggcatactg ctgggaagaa gcaatggaaa     1200

aaatgattga aaacttaaga caaacagaac tgaaactgac tcggaaggca gcctatgtga     1260

gatacttcaa tagctcagcc ttcttcttct cagggttctt tgtggtgttt ttatctgtgc     1320

ttccctatgc actaatcaaa ggaatcatcc tccggaaaat attcaccacc atctcattct     1380

gcattgttct gcgcatggcg gtcactcggc aatttccctg ggctgtacaa acatggtatg     1440

actctcttgg agcaataaac aaaatacagg atttcttaca aaagcaagaa tataagacat     1500

tggaatataa cttaacgact acagaagtag tgatggagaa tgtaacagcc ttctgggagg     1560

agggatttgg ggaattattt gagaaagcaa aacaaaacaa taacaataga aaaacttcta     1620

atggtgatga cagcctcttc ttcagtaatt tctcacttct tggtactcct gtcctgaaag     1680

atattaattt caagatagaa agaggacagt tgttggcggt tgctggatcc actggagcag     1740

gcaagacttc acttctaatg atgattatgg gagaactgga gccttcagag ggtaaaatta     1800

agcacagtgg aagaatttca ttctgttctc agttttcctg gattatgcct ggcaccatta     1860

aagaaaatat catctttggt gtttcctatg atgaatatag atacagaagc gtcatcaaag     1920

catgccaact agaagaggac atctccaagt ttgcagagaa agacaatata gttcttggag     1980

aaggtggaat cacactgagt ggaggtcaac gagcaagaat ttctttagca agagcagtat     2040

acaaagatgc tgatttgtat ttattagact ctccttttgg atacctagat gttttaacag     2100

aaaaagaaat atttgaaagc tgtgtctgta aactgatggc taacaaaact aggattttgg     2160

tcacttctaa aatggaacat ttaaagaaag ctgacaaaat attaattttg catgaaggta     2220

gcagctattt ttatgggaca ttttcagaac tccaaaatct acagccagac tttagctcaa     2280

aactcatggg atgtgattct ttcgaccaat ttagtgcaga aagaagaaat tcaatcctaa     2340

ctgagacctt acaccgtttc tcattagaag gagatgctcc tgtctcctgg acagaaacaa     2400

aaaaacaatc ttttaaacag actggagagt ttggggaaaa aaggaagaat tctattctca     2460

atccaatcaa ctctacgctt caggcacgaa ggaggcagtc tgtcctgaac ctgatgacac     2520

actcagttaa ccaaggtcag aacattcacc gaaagacaac agcatccaca cgaaaagtgt     2580

cactggcccc tcaggcaaac ttgactgaac tggatatata ttcaagaagg ttatctcaag     2640

aaactggctt ggaaataagt gaagaaatta acgaagaaga cttaaaggag tgcctttttg     2700

atgatatgga gagcatacca gcagtgacta catggaacac ataccttcga tatattactg     2760

tccacaagag cttaattttt gtgctaattt ggtgcttagt aatttttctg gcagaggtgg     2820

ctgcttcttt ggttgtgctg tggctccttg gaaacactcc tcttcaagac aaagggaata     2880

gtactcatag tagaaataac agctatgcag tgattatcac cagcaccagt tcgtattatg     2940

tgttttacat ttacgtggga gtagccgaca ctttgcttgc tatgggattc ttcagaggtc     3000

taccactggt gcatactcta atcacagtgt cgaaaatttt acaccacaaa atgttacatt     3060

ctgttcttca agcacctatg tcaaccctca acacgttgaa agcaggtggg attcttaata     3120

gattctccaa agatatagca attttggatg accttctgcc tcttaccata tttgacttca     3180

tccagttgtt attaattgtg attggagcta tagcagttgt cgcagtttta caaccctaca     3240

tctttgttgc aacagtgcca gtgatagtgg cttttattat gttgagagca tatttcctcc     3300

aaacctcaca gcaactcaaa caactggaat ctgaaggcag gagtccaatt ttcactcatc     3360

ttgttacaag cttaaaagga ctatggacac ttcgtgcctt cggacggcag ccttactttg     3420

aaactctgtt ccacaaagct ctgaatttac atactgccaa ctggttcttg tacctgtcaa     3480

cactgcgctg gttccaaatg agaatagaaa tgatttttgt catcttcttc attgctgtta     3540

ccttcatttc cattttaaca acaggagaag gagaaggaag agttggtatt atcctgactt     3600

tagccatgaa tatcatgagt acattgcagt gggctgtaaa ctccagcata gatgtggata     3660

gcttgatgcg atctgtgagc cgagtcttta agttcattga catgccaaca gaaggtaaac     3720

ctaccaagtc aaccaaacca tacaagaatg gccaactctc gaaagttatg attattgaga     3780

attcacacgt gaagaaagat gacatctggc cctcaggggg ccaaatgact gtcaaagatc     3840

tcacagcaaa atacacagaa ggtggaaatg ccatattaga gaacatttcc ttctcaataa     3900

gtcctggcca gagggtgggc ctcttgggaa gaactggatc agggaagagt actttgttat     3960

cagctttttt gagactactg aacactgaag gagaaatcca gatcgatggt gtgtcttggg     4020

attcaataac tttgcaacag tggaggaaag cctttggagt gataccacag aaagtattta     4080

ttttttctgg aacatttaga aaaaacttgg atccctatga acagtggagt gatcaagaaa     4140

tatggaaagt tgcagatgag gttgggctca gatctgtgat agaacagttt cctgggaagc     4200

ttgactttgt ccttgtggat gggggctgtg tcctaagcca tggccacaag cagttgatgt     4260

gcttggctag atctgttctc agtaaggcga agatcttgct gcttgatgaa cccagtgctc     4320

atttggatcc agtaacatac caaataatta gaagaactct aaaacaagca tttgctgatt     4380

gcacagtaat tctctgtgaa cacaggatag aagcaatgct ggaatgccaa caatttttgg     4440

tcatagaaga gaacaaagtg cggcagtacg attccatcca gaaactgctg aacgagagga     4500

gcctcttccg gcaagccatc agcccctccg acagggtgaa gctctttccc caccggaact     4560

caagcaagtg caagtctaag ccccagattg ctgctctgaa agaggagaca gaagaagagg     4620

tgcaagatac aaggctttag agagcagcat aaatgttgac atgggacatt tgctcatgga     4680

attggcaggc ctaataaaga gctcagatgc atcgatcaga gtgtgttggt tttttgtgtg     4740

tactgaggaa cccctagtga tggagttggc cactccctct ctgcgcgctc gctcgctcac     4800

tgaggccgcc cgggcaaagc ccgggcgtcg ggcgaccttt ggtcgcccgg cctcagtgag     4860

cgagcgagcg cgcagagagg gagtggccaa cccccccccc cccccccctg cagccagctg     4920

gcgtaatagc gaagaggccc gcaccgatcg cccttcccaa cagttgcgta gcctgaatgg     4980

cgaatggcgc gacgcgccct gtagcggcgc attaagcgcg gcgggtgtgg tggttacgcg     5040

cagcgtgacc gctacacttg ccagcgccct agcgcccgct cctttcgctt tcttcccttc     5100

ctttctcgcc acgttcgccg gctttccccg tcaagctcta aatcgggggc tccctttagg     5160

gttccgattt agtgctttac ggcacctcga ccccaaaaaa cttgattagg gtgatggttc     5220

acgtagtggg ccatcgccct gatagacggt ttttcgccct ttgacgttgg agtccacgtt     5280

ctttaatagt ggactcttgt tccaaactgg aacaacactc aaccctatct cggtctattc     5340

ttttgattta taagggattt tgccgatttc ggcctattgg ttaaaaaatg agctgattta     5400

acaaaaattt aacgcgaatt ttaacaaaat attaacgttt acaatttcct gatgcggtat     5460

tttctcctta cgcatctgtg cggtatttca caccgcatat ggtgcactct cagtacaatc     5520

tgctctgatg ccgcatagtt aagccagccc cgacacccgc caacacccgc tgacgcgccc     5580

tgacgggctt gtctgctccc ggcatccgct tacagacaag ctgtgaccgt ctccgggagc     5640

tgcatgtgtc agaggttttc accgtcatca ccgaaacgcg cgagacgaaa gggcctcgtg     5700

atacgcctat ttttataggt taatgtcatg ataataatgg tttcttagac gtcaggtggc     5760

acttttcggg gaaatgtgcg cggaacccct atttgtttat ttttctaaat acattcaaat     5820

atgtatccgc tcatgagaca ataaccctga taaatgcttc aataatattg aaaaaggaag     5880

agtatgagta ttcaacattt ccgtgtcgcc cttattccct tttttgcggc attttgcctt     5940

cctgtttttg ctcacccaga aacgctggtg aaagtaaaag atgctgaaga tcagttgggt     6000

gcacgagtgg gttacatcga actggatctc aacagcggta agatccttga gagttttcgc     6060

cccgaagaac gttttccaat gatgagcact tttaaagttc tgctatgtgg cgcggtatta     6120

tcccgtattg acgccgggca agagcaactc ggtcgccgca tacactattc tcagaatgac     6180

ttggttgagt actcaccagt cacagaaaag catcttacgg atggcatgac agtaagagaa     6240

ttatgcagtg ctgccataac catgagtgat aacactgcgg ccaacttact tctgacaacg     6300

atcggaggac cgaaggagct aaccgctttt ttgcacaaca tgggggatca tgtaactcgc     6360

cttgatcgtt gggaaccgga gctgaatgaa gccataccaa acgacgagcg tgacaccacg     6420

atgcctgtag caatggcaac aacgttgcgc aaactattaa ctggcgaact acttactcta     6480

gcttcccggc aacaattaat agactggatg gaggcggata aagttgcagg accacttctg     6540

cgctcggccc ttccggctgg ctggtttatt gctgataaat ctggagccgg tgagcgtggg     6600

tctcgcggta tcattgcagc actggggcca gatggtaagc cctcccgtat cgtagttatc     6660

tacacgacgg ggagtcaggc aactatggat gaacgaaata gacagatcgc tgagataggt     6720

gcctcactga ttaagcattg gtaactgtca gaccaagttt actcatatat actttagatt     6780

gatttaaaac ttcattttta atttaaaagg atctaggtga agatcctttt tgataatctc     6840

atgaccaaaa tcccttaacg tgagttttcg ttccactgag cgtcagaccc cgtagaaaag     6900

atcaaaggat cttcttgaga tccttttttt ctgcgcgtaa tctgctgctt gcaaacaaaa     6960

aaaccaccgc taccagcggt ggtttgtttg ccggatcaag agctaccaac tctttttccg     7020

aaggtaactg gcttcagcag agcgcagata ccaaatactg tccttctagt gtagccgtag     7080

ttaggccacc acttcaagaa ctctgtagca ccgcctacat acctcgctct gctaatcctg     7140

ttaccagtgg ctgctgccag tggcgataag tcgtgtctta ccgggttgga ctcaagacga     7200

tagttaccgg ataaggcgca gcggtcgggc tgaacggggg gttcgtgcac acagcccagc     7260

ttggagcgaa cgacctacac cgaactgaga tacctacagc gtgagcattg agaaagcgcc     7320

acgcttcccg aagggagaaa ggcggacagg tatccggtaa gcggcagggt cggaacagga     7380

gagcgcacga gggagcttcc agggggaaac gcctggtatc tttatagtcc tgtcgggttt     7440

cgccacctct gacttgagcg tcgatttttg tgatgctcgt caggggggcg gagcctatgg     7500

aaaaacgcca gcaacgcggc ctttttacgg ttcctggcct tttgctggcc ttttgctcac     7560

atgttctttc ctgcgttatc ccctgattct gtggataacc gtattaccgc ctttgagtga     7620

gctgataccg ctcgccgcag ccgaacgacc gagcgcagcg agtcagtgag cgaggaagcg     7680

gaagagcgcc caatacgcaa accgcctctc cccgcgcgtt ggccgattca ttaatgcagc     7740

tgggctgcag gggggggggg ggggggg                                         7767


<210>  13
<211>  725
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic Construct

<400>  13

Met Ala Ala Asp Gly Tyr Leu Pro Asp Trp Leu Glu Asp Thr Leu Ser 
1               5                   10                  15      


Glu Gly Ile Arg Gln Trp Trp Lys Leu Lys Pro Gly Pro Pro Pro Pro 
            20                  25                  30          


Lys Pro Ala Glu Arg His Lys Asp Asp Ser Arg Gly Leu Val Leu Pro 
        35                  40                  45              


Gly Tyr Lys Tyr Leu Gly Pro Phe Asn Gly Leu Asp Lys Gly Glu Pro 
    50                  55                  60                  


Val Asn Glu Ala Asp Ala Ala Ala Leu Glu His Asp Lys Ala Tyr Asp 
65                  70                  75                  80  


Arg Gln Leu Asp Ser Gly Asp Asn Pro Tyr Leu Lys Tyr Asn His Ala 
                85                  90                  95      


Asp Ala Glu Phe Gln Glu Arg Leu Lys Glu Asp Thr Ser Phe Gly Gly 
            100                 105                 110         


Asn Leu Gly Arg Ala Val Phe Gln Ala Lys Lys Arg Val Leu Glu Pro 
        115                 120                 125             


Phe Gly Leu Val Glu Glu Gly Ala Lys Thr Ala Pro Thr Gly Lys Arg 
    130                 135                 140                 


Ile Asp Asp His Phe Pro Lys Arg Lys Lys Ala Arg Thr Glu Glu Asp 
145                 150                 155                 160 


Ser Lys Pro Ser Thr Ser Ser Asp Ala Glu Ala Gly Pro Ser Gly Ser 
                165                 170                 175     


Gln Gln Leu Gln Ile Pro Ala Gln Pro Ala Ser Ser Leu Gly Ala Asp 
            180                 185                 190         


Thr Met Ser Ala Gly Gly Gly Gly Pro Leu Gly Asp Asn Asn Gln Gly 
        195                 200                 205             


Ala Asp Gly Val Gly Asn Ala Ser Gly Asp Trp His Cys Asp Ser Thr 
    210                 215                 220                 


Trp Met Gly Asp Arg Val Val Thr Lys Ser Thr Arg Thr Trp Val Leu 
225                 230                 235                 240 


Pro Ser Tyr Asn Asn His Gln Tyr Arg Glu Ile Lys Ser Gly Ser Val 
                245                 250                 255     


Asp Gly Ser Asn Ala Asn Ala Tyr Phe Gly Tyr Ser Thr Pro Trp Gly 
            260                 265                 270         


Tyr Phe Asp Phe Asn Arg Phe His Ser His Trp Ser Pro Arg Asp Trp 
        275                 280                 285             


Gln Arg Leu Ile Asn Asn Tyr Trp Gly Phe Arg Pro Arg Ser Leu Arg 
    290                 295                 300                 


Val Lys Ile Phe Asn Ile Gln Val Lys Glu Val Thr Val Gln Asp Ser 
305                 310                 315                 320 


Thr Thr Thr Ile Ala Asn Asn Leu Thr Ser Thr Val Gln Val Phe Thr 
                325                 330                 335     


Asp Asp Asp Tyr Gln Leu Pro Tyr Val Val Gly Asn Gly Thr Glu Gly 
            340                 345                 350         


Cys Leu Pro Ala Phe Pro Pro Gln Val Phe Thr Leu Pro Gln Tyr Gly 
        355                 360                 365             


Tyr Ala Thr Leu Asn Arg Asp Asn Thr Glu Asn Pro Thr Glu Arg Ser 
    370                 375                 380                 


Ser Phe Phe Cys Leu Glu Tyr Phe Pro Ser Lys Met Leu Arg Thr Gly 
385                 390                 395                 400 


Asn Asn Phe Glu Phe Thr Tyr Asn Phe Glu Glu Val Pro Phe His Ser 
                405                 410                 415     


Ser Phe Ala Pro Ser Gln Asn Leu Phe Lys Leu Ala Asn Pro Leu Val 
            420                 425                 430         


Asp Gln Tyr Leu Tyr Arg Phe Val Ser Thr Asn Asn Thr Gly Gly Val 
        435                 440                 445             


Gln Phe Asn Lys Asn Leu Ala Gly Arg Tyr Ala Asn Thr Tyr Lys Asn 
    450                 455                 460                 


Trp Phe Pro Gly Pro Met Gly Arg Thr Gln Gly Trp Asn Leu Gly Ser 
465                 470                 475                 480 


Gly Val Asn Arg Ala Ser Val Ser Ala Phe Ala Thr Thr Asn Arg Met 
                485                 490                 495     


Glu Leu Glu Gly Ala Ser Tyr Gln Val Pro Pro Gln Pro Asn Gly Met 
            500                 505                 510         


Thr Asn Asn Leu Gln Gly Ser Asn Thr Tyr Ala Leu Glu Asn Thr Met 
        515                 520                 525             


Ile Phe Asn Ser Gln Pro Ala Asn Pro Gly Thr Thr Ala Thr Tyr Leu 
    530                 535                 540                 


Glu Gly Asn Met Leu Ile Thr Ser Glu Ser Glu Thr Gln Pro Val Asn 
545                 550                 555                 560 


Arg Val Ala Tyr Asn Val Gly Gly Gln Met Ala Thr Asn Asn Gln Ser 
                565                 570                 575     


Ser Thr Thr Ala Pro Thr Thr Gly Thr Tyr Asn Leu Gln Glu Ile Val 
            580                 585                 590         


Pro Gly Ser Val Trp Met Glu Arg Asp Val Tyr Leu Gln Gly Pro Ile 
        595                 600                 605             


Trp Ala Lys Ile Pro Glu Thr Gly Ala His Phe His Pro Ser Pro Ala 
    610                 615                 620                 


Met Gly Gly Phe Gly Leu Lys His Pro Pro Pro Met Met Leu Ile Lys 
625                 630                 635                 640 


Asn Thr Pro Val Pro Gly Asn Ile Thr Ser Phe Ser Asp Val Pro Val 
                645                 650                 655     


Ser Ser Phe Ile Thr Gln Tyr Ser Thr Gly Gln Val Thr Val Glu Met 
            660                 665                 670         


Glu Trp Glu Leu Lys Lys Glu Asn Ser Lys Arg Trp Asn Pro Glu Ile 
        675                 680                 685             


Gln Tyr Thr Asn Asn Tyr Asn Asp Pro Gln Phe Val Asp Phe Ala Pro 
    690                 695                 700                 


Asp Ser Thr Gly Glu Tyr Arg Thr Thr Arg Pro Ile Gly Thr Arg Tyr 
705                 710                 715                 720 


Leu Thr Arg Pro Leu 
                725 


<210>  14
<211>  95
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Synthetic Construct

<400>  14
gtggtgagcg tctgggcatg tctgggcatg tctgggcatg tctgggcatg tcgggcattc       60

tgggcgtctg ggcatgtctg ggcatgtctg ggcat                                  95


<210>  15
<211>  141
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Synthetic Construct

<400>  15
ccactccctc tctgcgcgct cgctcgctca ctgaggccgc ccgggcaaag cccgggcgtc       60

gggcgacctt tggtcgcccg gcctcagtga gcgagcgagc gcgcagagag ggagtggcca      120

actccatcac taggggttcc t                                                141


<210>  16
<211>  143
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Synthetic Construct

<400>  16
aggaacccct agtgatggag ttggccactc cctctctgcg cgctcgctcg ctcactgagg       60

ccgggcgacc aaaggtcgcc cgacgcccgg gctttgcccg ggcggcctca gtgagcgagc      120

gagcgcgcag agagggagtg gcc                                              143


<210>  17
<211>  4884
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Synthetic Construct

<400>  17
ccactccctc tctgcgcgct cgctcgctca ctgaggccgc ccgggcaaag cccgggcgtc       60

gggcgacctt tggtcgcccg gcctcagtga gcgagcgagc gcgcagagag ggagtggcca      120

actccatcac taggggttcc tcagatctga attcgtggtg agcgtctggg catgtctggg      180

catgtctggg catgtctggg catgtcgggc attctgggcg tctgggcatg tctgggcatg      240

tctgggcatc tcgagaacgg tgacgtgcac gcgtgggcgg agccatcacg caggttgcta      300

tataagcaga gctcgtttag tgaaccgtca gagtcgagcc cgagagacca tgcagaggtc      360

gcctctggaa aaggccagcg ttgtctccaa actttttttc agctggacca gaccaatttt      420

gaggaaagga tacagacagc gcctggaatt gtcagacata taccaaatcc cttctgttga      480

ttctgctgac aatctatctg aaaaattgga aagagaatgg gatagagagc tggcttcaaa      540

gaaaaatcct aaactcatta atgcccttcg gcgatgtttt ttctggagat ttatgttcta      600

tggaatcttt ttatatttag gggaagtcac caaagcagta cagcctctct tactgggaag      660

aatcatagct tcctatgacc cggataacaa ggaggaacgc tctatcgcga tttatctagg      720

cataggctta tgccttctct ttattgtgag gacactgctc ctacacccag ccatttttgg      780

ccttcatcac attggaatgc agatgagaat agctatgttt agtttgattt ataagaagac      840

tttaaagctg tcaagccgtg ttctagataa aataagtatt ggacaacttg ttagtctcct      900

ttccaacaac ctgaacaaat ttgatgaagg acttgcattg gcacatttcg tgtggatcgc      960

tcctttgcaa gtggcactcc tcatggggct aatctgggag ttgttacagg cgtctgcctt     1020

ctgtggactt ggtttcctga tagtccttgc cctttttcag gctgggctag ggagaatgat     1080

gatgaagtac agagatcaga gagctgggaa gatcagtgaa agacttgtga ttacctcaga     1140

aatgatcgag aacatccaat ctgttaaggc atactgctgg gaagaagcaa tggaaaaaat     1200

gattgaaaac ttaagacaaa cagaactgaa actgactcgg aaggcagcct atgtgagata     1260

cttcaatagc tcagccttct tcttctcagg gttctttgtg gtgtttttat ctgtgcttcc     1320

ctatgcacta atcaaaggaa tcatcctccg gaaaatattc accaccatct cattctgcat     1380

tgttctgcgc atggcggtca ctcggcaatt tccctgggct gtacaaacat ggtatgactc     1440

tcttggagca ataaacaaaa tacaggattt cttacaaaag caagaatata agacattgga     1500

atataactta acgactacag aagtagtgat ggagaatgta acagccttct gggaggaggg     1560

atttggggaa ttatttgaga aagcaaaaca aaacaataac aatagaaaaa cttctaatgg     1620

tgatgacagc ctcttcttca gtaatttctc acttcttggt actcctgtcc tgaaagatat     1680

taatttcaag atagaaagag gacagttgtt ggcggttgct ggatccactg gagcaggcaa     1740

gacttcactt ctaatgatga ttatgggaga actggagcct tcagagggta aaattaagca     1800

cagtggaaga atttcattct gttctcagtt ttcctggatt atgcctggca ccattaaaga     1860

aaatatcatc tttggtgttt cctatgatga atatagatac agaagcgtca tcaaagcatg     1920

ccaactagaa gaggacatct ccaagtttgc agagaaagac aatatagttc ttggagaagg     1980

tggaatcaca ctgagtggag gtcaacgagc aagaatttct ttagcaagag cagtatacaa     2040

agatgctgat ttgtatttat tagactctcc ttttggatac ctagatgttt taacagaaaa     2100

agaaatattt gaaagctgtg tctgtaaact gatggctaac aaaactagga ttttggtcac     2160

ttctaaaatg gaacatttaa agaaagctga caaaatatta attttgcatg aaggtagcag     2220

ctatttttat gggacatttt cagaactcca aaatctacag ccagacttta gctcaaaact     2280

catgggatgt gattctttcg accaatttag tgcagaaaga agaaattcaa tcctaactga     2340

gaccttacac cgtttctcat tagaaggaga tgctcctgtc tcctggacag aaacaaaaaa     2400

acaatctttt aaacagactg gagagtttgg ggaaaaaagg aagaattcta ttctcaatcc     2460

aatcaactct acgcttcagg cacgaaggag gcagtctgtc ctgaacctga tgacacactc     2520

agttaaccaa ggtcagaaca ttcaccgaaa gacaacagca tccacacgaa aagtgtcact     2580

ggcccctcag gcaaacttga ctgaactgga tatatattca agaaggttat ctcaagaaac     2640

tggcttggaa ataagtgaag aaattaacga agaagactta aaggagtgcc tttttgatga     2700

tatggagagc ataccagcag tgactacatg gaacacatac cttcgatata ttactgtcca     2760

caagagctta atttttgtgc taatttggtg cttagtaatt tttctggcag aggtggctgc     2820

ttctttggtt gtgctgtggc tccttggaaa cactcctctt caagacaaag ggaatagtac     2880

tcatagtaga aataacagct atgcagtgat tatcaccagc accagttcgt attatgtgtt     2940

ttacatttac gtgggagtag ccgacacttt gcttgctatg ggattcttca gaggtctacc     3000

actggtgcat actctaatca cagtgtcgaa aattttacac cacaaaatgt tacattctgt     3060

tcttcaagca cctatgtcaa ccctcaacac gttgaaagca ggtgggattc ttaatagatt     3120

ctccaaagat atagcaattt tggatgacct tctgcctctt accatatttg acttcatcca     3180

gttgttatta attgtgattg gagctatagc agttgtcgca gttttacaac cctacatctt     3240

tgttgcaaca gtgccagtga tagtggcttt tattatgttg agagcatatt tcctccaaac     3300

ctcacagcaa ctcaaacaac tggaatctga aggcaggagt ccaattttca ctcatcttgt     3360

tacaagctta aaaggactat ggacacttcg tgccttcgga cggcagcctt actttgaaac     3420

tctgttccac aaagctctga atttacatac tgccaactgg ttcttgtacc tgtcaacact     3480

gcgctggttc caaatgagaa tagaaatgat ttttgtcatc ttcttcattg ctgttacctt     3540

catttccatt ttaacaacag gagaaggaga aggaagagtt ggtattatcc tgactttagc     3600

catgaatatc atgagtacat tgcagtgggc tgtaaactcc agcatagatg tggatagctt     3660

gatgcgatct gtgagccgag tctttaagtt cattgacatg ccaacagaag gtaaacctac     3720

caagtcaacc aaaccataca agaatggcca actctcgaaa gttatgatta ttgagaattc     3780

acacgtgaag aaagatgaca tctggccctc agggggccaa atgactgtca aagatctcac     3840

agcaaaatac acagaaggtg gaaatgccat attagagaac atttccttct caataagtcc     3900

tggccagagg gtgggcctct tgggaagaac tggatcaggg aagagtactt tgttatcagc     3960

ttttttgaga ctactgaaca ctgaaggaga aatccagatc gatggtgtgt cttgggattc     4020

aataactttg caacagtgga ggaaagcctt tggagtgata ccacagaaag tatttatttt     4080

ttctggaaca tttagaaaaa acttggatcc ctatgaacag tggagtgatc aagaaatatg     4140

gaaagttgca gatgaggttg ggctcagatc tgtgatagaa cagtttcctg ggaagcttga     4200

ctttgtcctt gtggatgggg gctgtgtcct aagccatggc cacaagcagt tgatgtgctt     4260

ggctagatct gttctcagta aggcgaagat cttgctgctt gatgaaccca gtgctcattt     4320

ggatccagta acataccaaa taattagaag aactctaaaa caagcatttg ctgattgcac     4380

agtaattctc tgtgaacaca ggatagaagc aatgctggaa tgccaacaat ttttggtcat     4440

agaagagaac aaagtgcggc agtacgattc catccagaaa ctgctgaacg agaggagcct     4500

cttccggcaa gccatcagcc cctccgacag ggtgaagctc tttccccacc ggaactcaag     4560

caagtgcaag tctaagcccc agattgctgc tctgaaagag gagacagaag aagaggtgca     4620

agatacaagg ctttagagag cagcataaat gttgacatgg gacatttgct catggaattg     4680

gcaggcctaa taaagagctc agatgcatcg atcagagtgt gttggttttt tgtgtgtact     4740

gaggaacccc tagtgatgga gttggccact ccctctctgc gcgctcgctc gctcactgag     4800

gccgggcgac caaaggtcgc ccgacgcccg ggctttgccc gggcggcctc agtgagcgag     4860

cgagcgcgca gagagggagt ggcc                                            4884


<210>  18
<211>  7749
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Synthetic Construct

<400>  18
ccactccctc tctgcgcgct cgctcgctca ctgaggccgc ccgggcaaag cccgggcgtc       60

gggcgacctt tggtcgcccg gcctcagtga gcgagcgagc gcgcagagag ggagtggcca      120

actccatcac taggggttcc tcagatctga attcgtggtg agcgtctggg catgtctggg      180

catgtctggg catgtctggg catgtcgggc attctgggcg tctgggcatg tctgggcatg      240

tctgggcatc tcgagaacgg tgacgtgcac gcgtgggcgg agccatcacg caggttgcta      300

tataagcaga gctcgtttag tgaaccgtca gagtcgagcc cgagagacca tgcagaggtc      360

gcctctggaa aaggccagcg ttgtctccaa actttttttc agctggacca gaccaatttt      420

gaggaaagga tacagacagc gcctggaatt gtcagacata taccaaatcc cttctgttga      480

ttctgctgac aatctatctg aaaaattgga aagagaatgg gatagagagc tggcttcaaa      540

gaaaaatcct aaactcatta atgcccttcg gcgatgtttt ttctggagat ttatgttcta      600

tggaatcttt ttatatttag gggaagtcac caaagcagta cagcctctct tactgggaag      660

aatcatagct tcctatgacc cggataacaa ggaggaacgc tctatcgcga tttatctagg      720

cataggctta tgccttctct ttattgtgag gacactgctc ctacacccag ccatttttgg      780

ccttcatcac attggaatgc agatgagaat agctatgttt agtttgattt ataagaagac      840

tttaaagctg tcaagccgtg ttctagataa aataagtatt ggacaacttg ttagtctcct      900

ttccaacaac ctgaacaaat ttgatgaagg acttgcattg gcacatttcg tgtggatcgc      960

tcctttgcaa gtggcactcc tcatggggct aatctgggag ttgttacagg cgtctgcctt     1020

ctgtggactt ggtttcctga tagtccttgc cctttttcag gctgggctag ggagaatgat     1080

gatgaagtac agagatcaga gagctgggaa gatcagtgaa agacttgtga ttacctcaga     1140

aatgatcgag aacatccaat ctgttaaggc atactgctgg gaagaagcaa tggaaaaaat     1200

gattgaaaac ttaagacaaa cagaactgaa actgactcgg aaggcagcct atgtgagata     1260

cttcaatagc tcagccttct tcttctcagg gttctttgtg gtgtttttat ctgtgcttcc     1320

ctatgcacta atcaaaggaa tcatcctccg gaaaatattc accaccatct cattctgcat     1380

tgttctgcgc atggcggtca ctcggcaatt tccctgggct gtacaaacat ggtatgactc     1440

tcttggagca ataaacaaaa tacaggattt cttacaaaag caagaatata agacattgga     1500

atataactta acgactacag aagtagtgat ggagaatgta acagccttct gggaggaggg     1560

atttggggaa ttatttgaga aagcaaaaca aaacaataac aatagaaaaa cttctaatgg     1620

tgatgacagc ctcttcttca gtaatttctc acttcttggt actcctgtcc tgaaagatat     1680

taatttcaag atagaaagag gacagttgtt ggcggttgct ggatccactg gagcaggcaa     1740

gacttcactt ctaatgatga ttatgggaga actggagcct tcagagggta aaattaagca     1800

cagtggaaga atttcattct gttctcagtt ttcctggatt atgcctggca ccattaaaga     1860

aaatatcatc tttggtgttt cctatgatga atatagatac agaagcgtca tcaaagcatg     1920

ccaactagaa gaggacatct ccaagtttgc agagaaagac aatatagttc ttggagaagg     1980

tggaatcaca ctgagtggag gtcaacgagc aagaatttct ttagcaagag cagtatacaa     2040

agatgctgat ttgtatttat tagactctcc ttttggatac ctagatgttt taacagaaaa     2100

agaaatattt gaaagctgtg tctgtaaact gatggctaac aaaactagga ttttggtcac     2160

ttctaaaatg gaacatttaa agaaagctga caaaatatta attttgcatg aaggtagcag     2220

ctatttttat gggacatttt cagaactcca aaatctacag ccagacttta gctcaaaact     2280

catgggatgt gattctttcg accaatttag tgcagaaaga agaaattcaa tcctaactga     2340

gaccttacac cgtttctcat tagaaggaga tgctcctgtc tcctggacag aaacaaaaaa     2400

acaatctttt aaacagactg gagagtttgg ggaaaaaagg aagaattcta ttctcaatcc     2460

aatcaactct acgcttcagg cacgaaggag gcagtctgtc ctgaacctga tgacacactc     2520

agttaaccaa ggtcagaaca ttcaccgaaa gacaacagca tccacacgaa aagtgtcact     2580

ggcccctcag gcaaacttga ctgaactgga tatatattca agaaggttat ctcaagaaac     2640

tggcttggaa ataagtgaag aaattaacga agaagactta aaggagtgcc tttttgatga     2700

tatggagagc ataccagcag tgactacatg gaacacatac cttcgatata ttactgtcca     2760

caagagctta atttttgtgc taatttggtg cttagtaatt tttctggcag aggtggctgc     2820

ttctttggtt gtgctgtggc tccttggaaa cactcctctt caagacaaag ggaatagtac     2880

tcatagtaga aataacagct atgcagtgat tatcaccagc accagttcgt attatgtgtt     2940

ttacatttac gtgggagtag ccgacacttt gcttgctatg ggattcttca gaggtctacc     3000

actggtgcat actctaatca cagtgtcgaa aattttacac cacaaaatgt tacattctgt     3060

tcttcaagca cctatgtcaa ccctcaacac gttgaaagca ggtgggattc ttaatagatt     3120

ctccaaagat atagcaattt tggatgacct tctgcctctt accatatttg acttcatcca     3180

gttgttatta attgtgattg gagctatagc agttgtcgca gttttacaac cctacatctt     3240

tgttgcaaca gtgccagtga tagtggcttt tattatgttg agagcatatt tcctccaaac     3300

ctcacagcaa ctcaaacaac tggaatctga aggcaggagt ccaattttca ctcatcttgt     3360

tacaagctta aaaggactat ggacacttcg tgccttcgga cggcagcctt actttgaaac     3420

tctgttccac aaagctctga atttacatac tgccaactgg ttcttgtacc tgtcaacact     3480

gcgctggttc caaatgagaa tagaaatgat ttttgtcatc ttcttcattg ctgttacctt     3540

catttccatt ttaacaacag gagaaggaga aggaagagtt ggtattatcc tgactttagc     3600

catgaatatc atgagtacat tgcagtgggc tgtaaactcc agcatagatg tggatagctt     3660

gatgcgatct gtgagccgag tctttaagtt cattgacatg ccaacagaag gtaaacctac     3720

caagtcaacc aaaccataca agaatggcca actctcgaaa gttatgatta ttgagaattc     3780

acacgtgaag aaagatgaca tctggccctc agggggccaa atgactgtca aagatctcac     3840

agcaaaatac acagaaggtg gaaatgccat attagagaac atttccttct caataagtcc     3900

tggccagagg gtgggcctct tgggaagaac tggatcaggg aagagtactt tgttatcagc     3960

ttttttgaga ctactgaaca ctgaaggaga aatccagatc gatggtgtgt cttgggattc     4020

aataactttg caacagtgga ggaaagcctt tggagtgata ccacagaaag tatttatttt     4080

ttctggaaca tttagaaaaa acttggatcc ctatgaacag tggagtgatc aagaaatatg     4140

gaaagttgca gatgaggttg ggctcagatc tgtgatagaa cagtttcctg ggaagcttga     4200

ctttgtcctt gtggatgggg gctgtgtcct aagccatggc cacaagcagt tgatgtgctt     4260

ggctagatct gttctcagta aggcgaagat cttgctgctt gatgaaccca gtgctcattt     4320

ggatccagta acataccaaa taattagaag aactctaaaa caagcatttg ctgattgcac     4380

agtaattctc tgtgaacaca ggatagaagc aatgctggaa tgccaacaat ttttggtcat     4440

agaagagaac aaagtgcggc agtacgattc catccagaaa ctgctgaacg agaggagcct     4500

cttccggcaa gccatcagcc cctccgacag ggtgaagctc tttccccacc ggaactcaag     4560

caagtgcaag tctaagcccc agattgctgc tctgaaagag gagacagaag aagaggtgca     4620

agatacaagg ctttagagag cagcataaat gttgacatgg gacatttgct catggaattg     4680

gcaggcctaa taaagagctc agatgcatcg atcagagtgt gttggttttt tgtgtgtact     4740

gaggaacccc tagtgatgga gttggccact ccctctctgc gcgctcgctc gctcactgag     4800

gccgggcgac caaaggtcgc ccgacgcccg ggctttgccc gggcggcctc agtgagcgag     4860

cgagcgcgca gagagggagt ggcccccccc cccccccccc ctgcagcctg gcgtaatagc     4920

gaagaggccc gcaccgatcg cccttcccaa cagttgcgca gcctgaatgg cgaatggacg     4980

cgccctgtag cggcgcatta agcgcggcgg gtgtggtggt tacgcgcagc gtgaccgcta     5040

cacttgccag cgccctagcg cccgctcctt tcgctttctt cccttccttt ctcgccacgt     5100

tcgccggctt tccccgtcaa gctctaaatc gggggctccc tttagggttc cgatttagtg     5160

ctttacggca cctcgacccc aaaaaacttg attagggtga tggttcacgt agtgggccat     5220

cgccctgata gacggttttt cgccctttga cgttggagtc cacgttcttt aatagtggac     5280

tcttgttcca aactggaaca acactcaacc ctatctcggt ctattctttt gatttataag     5340

ggattttgcc gatttcggcc tattggttaa aaaatgagct gatttaacaa aaatttaacg     5400

cgaattttaa caaaatatta acgcttacaa tttcctgatg cggtattttc tccttacgca     5460

tctgtgcggt atttcacacc gcatatggtg cactctcagt acaatctgct ctgatgccgc     5520

atagttaagc cagccccgac acccgccaac acccgctgac gcgccctgac gggcttgtct     5580

gctcccggca tccgcttaca gacaagctgt gaccgtctcc gggagctgca tgtgtcagag     5640

gttttcaccg tcatcaccga aacgcgcgag acgaaagggc ctcgtgatac gcctattttt     5700

ataggttaat gtcatgataa taatggtttc ttagacgtca ggtggcactt ttcggggaaa     5760

tgtgcgcgga acccctattt gtttattttt ctaaatacat tcaaatatgt atccgctcat     5820

gagacaataa ccctgataaa tgcttcaata atattgaaaa aggaagagta tgagtattca     5880

acatttccgt gtcgccctta ttcccttttt tgcggcattt tgccttcctg tttttgctca     5940

cccagaaacg ctggtgaaag taaaagatgc tgaagatcag ttgggtgcac gagtgggtta     6000

catcgaactg gatctcaaca gcggtaagat ccttgagagt tttcgccccg aagaacgttt     6060

tccaatgatg agcactttta aagttctgct atgtggcgcg gtattatccc gtattgacgc     6120

cgggcaagag caactcggtc gccgcataca ctattctcag aatgacttgg ttgagtactc     6180

accagtcaca gaaaagcatc ttacggatgg catgacagta agagaattat gcagtgctgc     6240

cataaccatg agtgataaca ctgcggccaa cttacttctg acaacgatcg gaggaccgaa     6300

ggagctaacc gcttttttgc acaacatggg ggatcatgta actcgccttg atcgttggga     6360

accggagctg aatgaagcca taccaaacga cgagcgtgac accacgatgc ctgtagcaat     6420

ggcaacaacg ttgcgcaaac tattaactgg cgaactactt actctagctt cccggcaaca     6480

attaatagac tggatggagg cggataaagt tgcaggacca cttctgcgct cggcccttcc     6540

ggctggctgg tttattgctg ataaatctgg agccggtgag cgtgggtctc gcggtatcat     6600

tgcagcactg gggccagatg gtaagccctc ccgtatcgta gttatctaca cgacggggag     6660

tcaggcaact atggatgaac gaaatagaca gatcgctgag ataggtgcct cactgattaa     6720

gcattggtaa ctgtcagacc aagtttactc atatatactt tagattgatt taaaacttca     6780

tttttaattt aaaaggatct aggtgaagat cctttttgat aatctcatga ccaaaatccc     6840

ttaacgtgag ttttcgttcc actgagcgtc agaccccgta gaaaagatca aaggatcttc     6900

ttgagatcct ttttttctgc gcgtaatctg ctgcttgcaa acaaaaaaac caccgctacc     6960

agcggtggtt tgtttgccgg atcaagagct accaactctt tttccgaagg taactggctt     7020

cagcagagcg cagataccaa atactgttct tctagtgtag ccgtagttag gccaccactt     7080

caagaactct gtagcaccgc ctacatacct cgctctgcta atcctgttac cagtggctgc     7140

tgccagtggc gataagtcgt gtcttaccgg gttggactca agacgatagt taccggataa     7200

ggcgcagcgg tcgggctgaa cggggggttc gtgcacacag cccagcttgg agcgaacgac     7260

ctacaccgaa ctgagatacc tacagcgtga gcattgagaa agcgccacgc ttcccgaagg     7320

gagaaaggcg gacaggtatc cggtaagcgg cagggtcgga acaggagagc gcacgaggga     7380

gcttccaggg ggaaacgcct ggtatcttta tagtcctgtc gggtttcgcc acctctgact     7440

tgagcgtcga tttttgtgat gctcgtcagg ggggcggagc ctatggaaaa acgccagcaa     7500

cgcggccttt ttacggttcc tggccttttg ctggcctttt gctcacatgt tctttcctgc     7560

gttatcccct gattctgtgg ataaccgtat taccgccttt gagtgagctg ataccgctcg     7620

ccgcagccga acgaccgagc gcagcgagtc agtgagcgag gaagcggaag agcgcccaat     7680

acgcaaaccg cctctccccg cgcgttggcc gattcattaa tgcaggctgc aggggggggg     7740

ggggggggg                                                             7749


<210>  19
<211>  1480
<212>  PRT
<213>  Homo sapiens

<400>  19

Met Gln Arg Ser Pro Leu Glu Lys Ala Ser Val Val Ser Lys Leu Phe 
1               5                   10                  15      


Phe Ser Trp Thr Arg Pro Ile Leu Arg Lys Gly Tyr Arg Gln Arg Leu 
            20                  25                  30          


Glu Leu Ser Asp Ile Tyr Gln Ile Pro Ser Val Asp Ser Ala Asp Asn 
        35                  40                  45              


Leu Ser Glu Lys Leu Glu Arg Glu Trp Asp Arg Glu Leu Ala Ser Lys 
    50                  55                  60                  


Lys Asn Pro Lys Leu Ile Asn Ala Leu Arg Arg Cys Phe Phe Trp Arg 
65                  70                  75                  80  


Phe Met Phe Tyr Gly Ile Phe Leu Tyr Leu Gly Glu Val Thr Lys Ala 
                85                  90                  95      


Val Gln Pro Leu Leu Leu Gly Arg Ile Ile Ala Ser Tyr Asp Pro Asp 
            100                 105                 110         


Asn Lys Glu Glu Arg Ser Ile Ala Ile Tyr Leu Gly Ile Gly Leu Cys 
        115                 120                 125             


Leu Leu Phe Ile Val Arg Thr Leu Leu Leu His Pro Ala Ile Phe Gly 
    130                 135                 140                 


Leu His His Ile Gly Met Gln Met Arg Ile Ala Met Phe Ser Leu Ile 
145                 150                 155                 160 


Tyr Lys Lys Thr Leu Lys Leu Ser Ser Arg Val Leu Asp Lys Ile Ser 
                165                 170                 175     


Ile Gly Gln Leu Val Ser Leu Leu Ser Asn Asn Leu Asn Lys Phe Asp 
            180                 185                 190         


Glu Gly Leu Ala Leu Ala His Phe Val Trp Ile Ala Pro Leu Gln Val 
        195                 200                 205             


Ala Leu Leu Met Gly Leu Ile Trp Glu Leu Leu Gln Ala Ser Ala Phe 
    210                 215                 220                 


Cys Gly Leu Gly Phe Leu Ile Val Leu Ala Leu Phe Gln Ala Gly Leu 
225                 230                 235                 240 


Gly Arg Met Met Met Lys Tyr Arg Asp Gln Arg Ala Gly Lys Ile Ser 
                245                 250                 255     


Glu Arg Leu Val Ile Thr Ser Glu Met Ile Glu Asn Ile Gln Ser Val 
            260                 265                 270         


Lys Ala Tyr Cys Trp Glu Glu Ala Met Glu Lys Met Ile Glu Asn Leu 
        275                 280                 285             


Arg Gln Thr Glu Leu Lys Leu Thr Arg Lys Ala Ala Tyr Val Arg Tyr 
    290                 295                 300                 


Phe Asn Ser Ser Ala Phe Phe Phe Ser Gly Phe Phe Val Val Phe Leu 
305                 310                 315                 320 


Ser Val Leu Pro Tyr Ala Leu Ile Lys Gly Ile Ile Leu Arg Lys Ile 
                325                 330                 335     


Phe Thr Thr Ile Ser Phe Cys Ile Val Leu Arg Met Ala Val Thr Arg 
            340                 345                 350         


Gln Phe Pro Trp Ala Val Gln Thr Trp Tyr Asp Ser Leu Gly Ala Ile 
        355                 360                 365             


Asn Lys Ile Gln Asp Phe Leu Gln Lys Gln Glu Tyr Lys Thr Leu Glu 
    370                 375                 380                 


Tyr Asn Leu Thr Thr Thr Glu Val Val Met Glu Asn Val Thr Ala Phe 
385                 390                 395                 400 


Trp Glu Glu Gly Phe Gly Glu Leu Phe Glu Lys Ala Lys Gln Asn Asn 
                405                 410                 415     


Asn Asn Arg Lys Thr Ser Asn Gly Asp Asp Ser Leu Phe Phe Ser Asn 
            420                 425                 430         


Phe Ser Leu Leu Gly Thr Pro Val Leu Lys Asp Ile Asn Phe Lys Ile 
        435                 440                 445             


Glu Arg Gly Gln Leu Leu Ala Val Ala Gly Ser Thr Gly Ala Gly Lys 
    450                 455                 460                 


Thr Ser Leu Leu Met Val Ile Met Gly Glu Leu Glu Pro Ser Glu Gly 
465                 470                 475                 480 


Lys Ile Lys His Ser Gly Arg Ile Ser Phe Cys Ser Gln Phe Ser Trp 
                485                 490                 495     


Ile Met Pro Gly Thr Ile Lys Glu Asn Ile Ile Phe Gly Val Ser Tyr 
            500                 505                 510         


Asp Glu Tyr Arg Tyr Arg Ser Val Ile Lys Ala Cys Gln Leu Glu Glu 
        515                 520                 525             


Asp Ile Ser Lys Phe Ala Glu Lys Asp Asn Ile Val Leu Gly Glu Gly 
    530                 535                 540                 


Gly Ile Thr Leu Ser Gly Gly Gln Arg Ala Arg Ile Ser Leu Ala Arg 
545                 550                 555                 560 


Ala Val Tyr Lys Asp Ala Asp Leu Tyr Leu Leu Asp Ser Pro Phe Gly 
                565                 570                 575     


Tyr Leu Asp Val Leu Thr Glu Lys Glu Ile Phe Glu Ser Cys Val Cys 
            580                 585                 590         


Lys Leu Met Ala Asn Lys Thr Arg Ile Leu Val Thr Ser Lys Met Glu 
        595                 600                 605             


His Leu Lys Lys Ala Asp Lys Ile Leu Ile Leu His Glu Gly Ser Ser 
    610                 615                 620                 


Tyr Phe Tyr Gly Thr Phe Ser Glu Leu Gln Asn Leu Gln Pro Asp Phe 
625                 630                 635                 640 


Ser Ser Lys Leu Met Gly Cys Asp Ser Phe Asp Gln Phe Ser Ala Glu 
                645                 650                 655     


Arg Arg Asn Ser Ile Leu Thr Glu Thr Leu His Arg Phe Ser Leu Glu 
            660                 665                 670         


Gly Asp Ala Pro Val Ser Trp Thr Glu Thr Lys Lys Gln Ser Phe Lys 
        675                 680                 685             


Gln Thr Gly Glu Phe Gly Glu Lys Arg Lys Asn Ser Ile Leu Asn Pro 
    690                 695                 700                 


Ile Asn Ser Ile Arg Lys Phe Ser Ile Val Gln Lys Thr Pro Leu Gln 
705                 710                 715                 720 


Met Asn Gly Ile Glu Glu Asp Ser Asp Glu Pro Leu Glu Arg Arg Leu 
                725                 730                 735     


Ser Leu Val Pro Asp Ser Glu Gln Gly Glu Ala Ile Leu Pro Arg Ile 
            740                 745                 750         


Ser Val Ile Ser Thr Gly Pro Thr Leu Gln Ala Arg Arg Arg Gln Ser 
        755                 760                 765             


Val Leu Asn Leu Met Thr His Ser Val Asn Gln Gly Gln Asn Ile His 
    770                 775                 780                 


Arg Lys Thr Thr Ala Ser Thr Arg Lys Val Ser Leu Ala Pro Gln Ala 
785                 790                 795                 800 


Asn Leu Thr Glu Leu Asp Ile Tyr Ser Arg Arg Leu Ser Gln Glu Thr 
                805                 810                 815     


Gly Leu Glu Ile Ser Glu Glu Ile Asn Glu Glu Asp Leu Lys Glu Cys 
            820                 825                 830         


Phe Phe Asp Asp Met Glu Ser Ile Pro Ala Val Thr Thr Trp Asn Thr 
        835                 840                 845             


Tyr Leu Arg Tyr Ile Thr Val His Lys Ser Leu Ile Phe Val Leu Ile 
    850                 855                 860                 


Trp Cys Leu Val Ile Phe Leu Ala Glu Val Ala Ala Ser Leu Val Val 
865                 870                 875                 880 


Leu Trp Leu Leu Gly Asn Thr Pro Leu Gln Asp Lys Gly Asn Ser Thr 
                885                 890                 895     


His Ser Arg Asn Asn Ser Tyr Ala Val Ile Ile Thr Ser Thr Ser Ser 
            900                 905                 910         


Tyr Tyr Val Phe Tyr Ile Tyr Val Gly Val Ala Asp Thr Leu Leu Ala 
        915                 920                 925             


Met Gly Phe Phe Arg Gly Leu Pro Leu Val His Thr Leu Ile Thr Val 
    930                 935                 940                 


Ser Lys Ile Leu His His Lys Met Leu His Ser Val Leu Gln Ala Pro 
945                 950                 955                 960 


Met Ser Thr Leu Asn Thr Leu Lys Ala Gly Gly Ile Leu Asn Arg Phe 
                965                 970                 975     


Ser Lys Asp Ile Ala Ile Leu Asp Asp Leu Leu Pro Leu Thr Ile Phe 
            980                 985                 990         


Asp Phe Ile Gln Leu Leu Leu Ile  Val Ile Gly Ala Ile  Ala Val Val 
        995                 1000                 1005             


Ala Val  Leu Gln Pro Tyr Ile  Phe Val Ala Thr Val  Pro Val Ile 
    1010                 1015                 1020             


Val Ala  Phe Ile Met Leu Arg  Ala Tyr Phe Leu Gln  Thr Ser Gln 
    1025                 1030                 1035             


Gln Leu  Lys Gln Leu Glu Ser  Glu Gly Arg Ser Pro  Ile Phe Thr 
    1040                 1045                 1050             


His Leu  Val Thr Ser Leu Lys  Gly Leu Trp Thr Leu  Arg Ala Phe 
    1055                 1060                 1065             


Gly Arg  Gln Pro Tyr Phe Glu  Thr Leu Phe His Lys  Ala Leu Asn 
    1070                 1075                 1080             


Leu His  Thr Ala Asn Trp Phe  Leu Tyr Leu Ser Thr  Leu Arg Trp 
    1085                 1090                 1095             


Phe Gln  Met Arg Ile Glu Met  Ile Phe Val Ile Phe  Phe Ile Ala 
    1100                 1105                 1110             


Val Thr  Phe Ile Ser Ile Leu  Thr Thr Gly Glu Gly  Glu Gly Arg 
    1115                 1120                 1125             


Val Gly  Ile Ile Leu Thr Leu  Ala Met Asn Ile Met  Ser Thr Leu 
    1130                 1135                 1140             


Gln Trp  Ala Val Asn Ser Ser  Ile Asp Val Asp Ser  Leu Met Arg 
    1145                 1150                 1155             


Ser Val  Ser Arg Val Phe Lys  Phe Ile Asp Met Pro  Thr Glu Gly 
    1160                 1165                 1170             


Lys Pro  Thr Lys Ser Thr Lys  Pro Tyr Lys Asn Gly  Gln Leu Ser 
    1175                 1180                 1185             


Lys Val  Met Ile Ile Glu Asn  Ser His Val Lys Lys  Asp Asp Ile 
    1190                 1195                 1200             


Trp Pro  Ser Gly Gly Gln Met  Thr Val Lys Asp Leu  Thr Ala Lys 
    1205                 1210                 1215             


Tyr Thr  Glu Gly Gly Asn Ala  Ile Leu Glu Asn Ile  Ser Phe Ser 
    1220                 1225                 1230             


Ile Ser  Pro Gly Gln Arg Val  Gly Leu Leu Gly Arg  Thr Gly Ser 
    1235                 1240                 1245             


Gly Lys  Ser Thr Leu Leu Ser  Ala Phe Leu Arg Leu  Leu Asn Thr 
    1250                 1255                 1260             


Glu Gly  Glu Ile Gln Ile Asp  Gly Val Ser Trp Asp  Ser Ile Thr 
    1265                 1270                 1275             


Leu Gln  Gln Trp Arg Lys Ala  Phe Gly Val Ile Pro  Gln Lys Val 
    1280                 1285                 1290             


Phe Ile  Phe Ser Gly Thr Phe  Arg Lys Asn Leu Asp  Pro Tyr Glu 
    1295                 1300                 1305             


Gln Trp  Ser Asp Gln Glu Ile  Trp Lys Val Ala Asp  Glu Val Gly 
    1310                 1315                 1320             


Leu Arg  Ser Val Ile Glu Gln  Phe Pro Gly Lys Leu  Asp Phe Val 
    1325                 1330                 1335             


Leu Val  Asp Gly Gly Cys Val  Leu Ser His Gly His  Lys Gln Leu 
    1340                 1345                 1350             


Met Cys  Leu Ala Arg Ser Val  Leu Ser Lys Ala Lys  Ile Leu Leu 
    1355                 1360                 1365             


Leu Asp  Glu Pro Ser Ala His  Leu Asp Pro Val Thr  Tyr Gln Ile 
    1370                 1375                 1380             


Ile Arg  Arg Thr Leu Lys Gln  Ala Phe Ala Asp Cys  Thr Val Ile 
    1385                 1390                 1395             


Leu Cys  Glu His Arg Ile Glu  Ala Met Leu Glu Cys  Gln Gln Phe 
    1400                 1405                 1410             


Leu Val  Ile Glu Glu Asn Lys  Val Arg Gln Tyr Asp  Ser Ile Gln 
    1415                 1420                 1425             


Lys Leu  Leu Asn Glu Arg Ser  Leu Phe Arg Gln Ala  Ile Ser Pro 
    1430                 1435                 1440             


Ser Asp  Arg Val Lys Leu Phe  Pro His Arg Asn Ser  Ser Lys Cys 
    1445                 1450                 1455             


Lys Ser  Lys Pro Gln Ile Ala  Ala Leu Lys Glu Glu  Thr Glu Glu 
    1460                 1465                 1470             


Glu Val  Gln Asp Thr Arg Leu  
    1475                 1480 


