                         SEQUENCE LISTING

<110>  Kyverna Therapeutics, Inc.
 
<120>  METHODS AND COMPOSITIONS FOR TREATING DISEASE USING TARGETED 
       FOXP3+CD4+ T CELLS AND CELLULAR SUICIDE AGENTS

<130>  47902-0022WO1

<150>  63/175,521
<151>  2021-04-15

<160>  17    

<170>  PatentIn version 3.5

<210>  1
<211>  1296
<212>  DNA
<213>  Homo sapiens

<400>  1
atgcccaacc ccaggcctgg caagccctcg gccccttcct tggcccttgg cccatcccca       60

ggagcctcgc ccagctggag ggctgcaccc aaagcctcag acctgctggg ggcccggggc      120

ccagggggaa ccttccaggg ccgagatctt cgaggcgggg cccatgcctc ctcttcttcc      180

ttgaacccca tgccaccatc gcagctgcag ctgcccacac tgcccctagt catggtggca      240

ccctccgggg cacggctggg ccccttgccc cacttacagg cactcctcca ggacaggcca      300

catttcatgc accagctctc aacggtggat gcccacgccc ggacccctgt gctgcaggtg      360

caccccctgg agagcccagc catgatcagc ctcacaccac ccaccaccgc cactggggtc      420

ttctccctca aggcccggcc tggcctccca cctgggatca acgtggccag cctggaatgg      480

gtgtccaggg agccggcact gctctgcacc ttcccaaatc ccagtgcacc caggaaggac      540

agcacccttt cggctgtgcc ccagagctcc tacccactgc tggcaaatgg tgtctgcaag      600

tggcccggat gtgagaaggt cttcgaagag ccagaggact tcctcaagca ctgccaggcg      660

gaccatcttc tggatgagaa gggcagggca caatgtctcc tccagagaga gatggtacag      720

tctctggagc agcagctggt gctggagaag gagaagctga gtgccatgca ggcccacctg      780

gctgggaaaa tggcactgac caaggcttca tctgtggcat catccgacaa gggctcctgc      840

tgcatcgtag ctgctggcag ccaaggccct gtcgtcccag cctggtctgg cccccgggag      900

gcccctgaca gcctgtttgc tgtccggagg cacctgtggg gtagccatgg aaacagcaca      960

ttcccagagt tcctccacaa catggactac ttcaagttcc acaacatgcg accccctttc     1020

acctacgcca cgctcatccg ctgggccatc ctggaggctc cagagaagca gcggacactc     1080

aatgagatct accactggtt cacacgcatg tttgccttct tcagaaacca tcctgccacc     1140

tggaagaacg ccatccgcca caacctgagt ctgcacaagt gctttgtgcg ggtggagagc     1200

gagaaggggg ctgtgtggac cgtggatgag ctggagttcc gcaagaaacg gagccagagg     1260

cccagcaggt gttccaaccc tacacctggc ccctga                               1296


<210>  2
<211>  431
<212>  PRT
<213>  Homo sapiens

<400>  2

Met Pro Asn Pro Arg Pro Gly Lys Pro Ser Ala Pro Ser Leu Ala Leu 
1               5                   10                  15      


Gly Pro Ser Pro Gly Ala Ser Pro Ser Trp Arg Ala Ala Pro Lys Ala 
            20                  25                  30          


Ser Asp Leu Leu Gly Ala Arg Gly Pro Gly Gly Thr Phe Gln Gly Arg 
        35                  40                  45              


Asp Leu Arg Gly Gly Ala His Ala Ser Ser Ser Ser Leu Asn Pro Met 
    50                  55                  60                  


Pro Pro Ser Gln Leu Gln Leu Pro Thr Leu Pro Leu Val Met Val Ala 
65                  70                  75                  80  


Pro Ser Gly Ala Arg Leu Gly Pro Leu Pro His Leu Gln Ala Leu Leu 
                85                  90                  95      


Gln Asp Arg Pro His Phe Met His Gln Leu Ser Thr Val Asp Ala His 
            100                 105                 110         


Ala Arg Thr Pro Val Leu Gln Val His Pro Leu Glu Ser Pro Ala Met 
        115                 120                 125             


Ile Ser Leu Thr Pro Pro Thr Thr Ala Thr Gly Val Phe Ser Leu Lys 
    130                 135                 140                 


Ala Arg Pro Gly Leu Pro Pro Gly Ile Asn Val Ala Ser Leu Glu Trp 
145                 150                 155                 160 


Val Ser Arg Glu Pro Ala Leu Leu Cys Thr Phe Pro Asn Pro Ser Ala 
                165                 170                 175     


Pro Arg Lys Asp Ser Thr Leu Ser Ala Val Pro Gln Ser Ser Tyr Pro 
            180                 185                 190         


Leu Leu Ala Asn Gly Val Cys Lys Trp Pro Gly Cys Glu Lys Val Phe 
        195                 200                 205             


Glu Glu Pro Glu Asp Phe Leu Lys His Cys Gln Ala Asp His Leu Leu 
    210                 215                 220                 


Asp Glu Lys Gly Arg Ala Gln Cys Leu Leu Gln Arg Glu Met Val Gln 
225                 230                 235                 240 


Ser Leu Glu Gln Gln Leu Val Leu Glu Lys Glu Lys Leu Ser Ala Met 
                245                 250                 255     


Gln Ala His Leu Ala Gly Lys Met Ala Leu Thr Lys Ala Ser Ser Val 
            260                 265                 270         


Ala Ser Ser Asp Lys Gly Ser Cys Cys Ile Val Ala Ala Gly Ser Gln 
        275                 280                 285             


Gly Pro Val Val Pro Ala Trp Ser Gly Pro Arg Glu Ala Pro Asp Ser 
    290                 295                 300                 


Leu Phe Ala Val Arg Arg His Leu Trp Gly Ser His Gly Asn Ser Thr 
305                 310                 315                 320 


Phe Pro Glu Phe Leu His Asn Met Asp Tyr Phe Lys Phe His Asn Met 
                325                 330                 335     


Arg Pro Pro Phe Thr Tyr Ala Thr Leu Ile Arg Trp Ala Ile Leu Glu 
            340                 345                 350         


Ala Pro Glu Lys Gln Arg Thr Leu Asn Glu Ile Tyr His Trp Phe Thr 
        355                 360                 365             


Arg Met Phe Ala Phe Phe Arg Asn His Pro Ala Thr Trp Lys Asn Ala 
    370                 375                 380                 


Ile Arg His Asn Leu Ser Leu His Lys Cys Phe Val Arg Val Glu Ser 
385                 390                 395                 400 


Glu Lys Gly Ala Val Trp Thr Val Asp Glu Leu Glu Phe Arg Lys Lys 
                405                 410                 415     


Arg Ser Gln Arg Pro Ser Arg Cys Ser Asn Pro Thr Pro Gly Pro 
            420                 425                 430     


<210>  3
<211>  232
<212>  DNA
<213>  Homo sapiens

<400>  3
cctgcccttg gacaaggacc cgatgcccaa ccccaggcct ggcaagccct cggccccttc       60

cttggccctt ggcccatccc caggagcctc gcccagctgg agggctgcac ccaaagcctc      120

agacctgctg ggggcccggg gcccaggggg aaccttccag ggccgagatc ttcgaggcgg      180

ggcccatgcc tcctcttctt ccttgaaccc catgccacca tcgcagctgc ag              232


<210>  4
<211>  1290
<212>  DNA
<213>  Mus musculus

<400>  4
atgcccaacc ctaggccagc caagcctatg gctccttcct tggcccttgg cccatcccca       60

ggagtcttgc caagctggaa gactgcaccc aagggctcag aacttctagg gaccaggggc      120

tctgggggac ccttccaagg tcgggacctg cgaagtgggg cccacacctc ttcttccttg      180

aaccccctgc caccatccca gctgcagctg cctacagtgc ccctagtcat ggtggcaccg      240

tctggggccc gactaggtcc ctcaccccac ctacaggccc ttctccagga cagaccacac      300

ttcatgcatc agctctccac tgtggatgcc catgcccaga cccctgtgct ccaagtgcgt      360

ccactggaca acccagccat gatcagcctc ccaccacctt ctgctgccac tggggtcttc      420

tccctcaagg cccggcctgg cctgccacct gggatcaatg tggccagtct ggaatgggtg      480

tccagggagc cagctctact ctgcaccttc ccacgctcgg gtacacccag gaaagacagc      540

aaccttttgg ctgcacccca aggatcctac ccactgctgg caaatggagt ctgcaagtgg      600

cctggttgtg agaaggtctt cgaggagcca gaagagtttc tcaagcactg ccaagcagat      660

catctcctgg atgagaaagg caaggcccag tgcctcctcc agagagaagt ggtgcagtct      720

ctggagcagc agctggagct ggaaaaggag aagctgggag ctatgcaggc ccacctggct      780

gggaagatgg cgctggccaa ggctccatct gtggcctcaa tggacaagag ctcttgctgc      840

atcgtagcca ccagtactca gggcagtgtg ctcccggcct ggtctgctcc tcgggaggct      900

ccagacggcg gcctgtttgc agtgcggagg cacctctggg gaagccatgg caatagttcc      960

ttcccagagt tcttccacaa catggactac ttcaagtacc acaatatgcg accccctttc     1020

acctatgcca cccttatccg atgggccatc ctggaagccc cggagaggca gaggacactc     1080

aatgaaatct accattggtt tactcgcatg ttcgcctact tcagaaacca ccccgccacc     1140

tggaagaatg ccatccgcca caacctgagc ctgcacaagt gctttgtgcg agtggagagc     1200

gagaagggag cagtgtggac cgtagatgaa tttgagtttc gcaagaagag gagccaacgc     1260

cccaacaagt gctccaatcc ctgcccttga                                      1290


<210>  5
<211>  429
<212>  PRT
<213>  Mus musculus

<400>  5

Met Pro Asn Pro Arg Pro Ala Lys Pro Met Ala Pro Ser Leu Ala Leu 
1               5                   10                  15      


Gly Pro Ser Pro Gly Val Leu Pro Ser Trp Lys Thr Ala Pro Lys Gly 
            20                  25                  30          


Ser Glu Leu Leu Gly Thr Arg Gly Ser Gly Gly Pro Phe Gln Gly Arg 
        35                  40                  45              


Asp Leu Arg Ser Gly Ala His Thr Ser Ser Ser Leu Asn Pro Leu Pro 
    50                  55                  60                  


Pro Ser Gln Leu Gln Leu Pro Thr Val Pro Leu Val Met Val Ala Pro 
65                  70                  75                  80  


Ser Gly Ala Arg Leu Gly Pro Ser Pro His Leu Gln Ala Leu Leu Gln 
                85                  90                  95      


Asp Arg Pro His Phe Met His Gln Leu Ser Thr Val Asp Ala His Ala 
            100                 105                 110         


Gln Thr Pro Val Leu Gln Val Arg Pro Leu Asp Asn Pro Ala Met Ile 
        115                 120                 125             


Ser Leu Pro Pro Pro Ser Ala Ala Thr Gly Val Phe Ser Leu Lys Ala 
    130                 135                 140                 


Arg Pro Gly Leu Pro Pro Gly Ile Asn Val Ala Ser Leu Glu Trp Val 
145                 150                 155                 160 


Ser Arg Glu Pro Ala Leu Leu Cys Thr Phe Pro Arg Ser Gly Thr Pro 
                165                 170                 175     


Arg Lys Asp Ser Asn Leu Leu Ala Ala Pro Gln Gly Ser Tyr Pro Leu 
            180                 185                 190         


Leu Ala Asn Gly Val Cys Lys Trp Pro Gly Cys Glu Lys Val Phe Glu 
        195                 200                 205             


Glu Pro Glu Glu Phe Leu Lys His Cys Gln Ala Asp His Leu Leu Asp 
    210                 215                 220                 


Glu Lys Gly Lys Ala Gln Cys Leu Leu Gln Arg Glu Val Val Gln Ser 
225                 230                 235                 240 


Leu Glu Gln Gln Leu Glu Leu Glu Lys Glu Lys Leu Gly Ala Met Gln 
                245                 250                 255     


Ala His Leu Ala Gly Lys Met Ala Leu Ala Lys Ala Pro Ser Val Ala 
            260                 265                 270         


Ser Met Asp Lys Ser Ser Cys Cys Ile Val Ala Thr Ser Thr Gln Gly 
        275                 280                 285             


Ser Val Leu Pro Ala Trp Ser Ala Pro Arg Glu Ala Pro Asp Gly Gly 
    290                 295                 300                 


Leu Phe Ala Val Arg Arg His Leu Trp Gly Ser His Gly Asn Ser Ser 
305                 310                 315                 320 


Phe Pro Glu Phe Phe His Asn Met Asp Tyr Phe Lys Tyr His Asn Met 
                325                 330                 335     


Arg Pro Pro Phe Thr Tyr Ala Thr Leu Ile Arg Trp Ala Ile Leu Glu 
            340                 345                 350         


Ala Pro Glu Arg Gln Arg Thr Leu Asn Glu Ile Tyr His Trp Phe Thr 
        355                 360                 365             


Arg Met Phe Ala Tyr Phe Arg Asn His Pro Ala Thr Trp Lys Asn Ala 
    370                 375                 380                 


Ile Arg His Asn Leu Ser Leu His Lys Cys Phe Val Arg Val Glu Ser 
385                 390                 395                 400 


Glu Lys Gly Ala Val Trp Thr Val Asp Glu Phe Glu Phe Arg Lys Lys 
                405                 410                 415     


Arg Ser Gln Arg Pro Asn Lys Cys Ser Asn Pro Cys Pro 
            420                 425                 


<210>  6
<211>  1295
<212>  DNA
<213>  Rattus Rattus

<400>  6
atgcccaacc caaggccagc taagcctatg gctccttcct tggcccctgg cccgtcccca       60

ggaggcttgc caagctggaa gactgcgccc aagggctcag aactcctagg gaccaggggt      120

cctgggggac ccttccaagg ccgggacctg cgaagtgggg cccacacctc ctcttcttcc      180

ttgaaccccc tgccaccatc acagctgcag ctgcctacag tgcccctagt catggtggca      240

ccctctgggg cccgactagg cccctcaccg cacctgcagg cacttctcca ggacagacca      300

cactttatgc atcagctctc cactgtagac gcacatggcc acacccctgt gctacaagtg      360

cgcccactgg acaacccagc gatgatcggc ctcccaccgc ctactgctgc cactggagtc      420

ttctccctca aggcccggcc tggcctgcca cctgggatca atgtggccag tctggaatgg      480

gtgtccaggg agccggctct actctgcacc ttcccacgct caggtacacc caggaaagac      540

agcaaccttc tggctgcacc acaaggatcc tacccactgc tggcaaacgg agtctgcaag      600

tggccgggtt gtgagaaggc cttcgaggag ccgggagagt ttctcaagca ctgccaagca      660

gatcacctct tggatgagaa gggcaaggcc cagtgcctcc tccagagaga agtggtgcag      720

tctctggagc agcagctgga gctggaaaag gagaagctgg gagctatgca ggcccacctg      780

gctgggaaga tggcattgac aaaagctcca cctgtggcct cagtggacaa gagctcctgc      840

tgcctcgtag ccaccagcac ccagggcagc gtcctcccgg cctggtctag tccccgggaa      900

gcttcagaca gcttgtttgc tgtgcggaga cacctctggg gaagccatgg aaacagcacc      960

tttccagagt tcttccacaa catggactac ttcaagtacc ataatatgcg gccccctttc     1020

acctatgcca ccctcatccg atgggccatc ctggaagctc cagagaggca gaggacactc     1080

aatgaaatct accattggtt cacacgcatg ttcgcctact tcagaaacca ccccgccacc     1140

tggaagaatg ccatccgcca caacctgagc ctgcacaagt gctttgtgcg agtggagagt     1200

gagaagggag cagtgtggac cgtagatgaa tttgagtttc gcaagaagag gagccaacgc     1260

cccagcaagt gctccaaccc ctgcccttga cctca                                1295


<210>  7
<211>  429
<212>  PRT
<213>  Rattus Rattus

<400>  7

Met Pro Asn Pro Arg Pro Ala Lys Pro Met Ala Pro Ser Leu Ala Pro 
1               5                   10                  15      


Gly Pro Ser Pro Gly Gly Leu Pro Ser Trp Lys Thr Ala Pro Lys Gly 
            20                  25                  30          


Ser Glu Leu Leu Gly Thr Arg Gly Pro Gly Gly Pro Phe Gln Gly Arg 
        35                  40                  45              


Asp Leu Arg Ser Gly Ala His Thr Ser Ser Ser Ser Leu Asn Pro Leu 
    50                  55                  60                  


Pro Pro Ser Gln Leu Gln Leu Pro Thr Val Pro Leu Val Met Val Ala 
65                  70                  75                  80  


Pro Ser Gly Ala Arg Leu Gly Pro Ser Pro His Leu Gln Ala Leu Leu 
                85                  90                  95      


Gln Asp Arg Pro His Phe Met His Gln Leu Ser Thr Val Asp Ala His 
            100                 105                 110         


Gly His Thr Pro Val Leu Gln Val Arg Pro Leu Asp Asn Pro Ala Met 
        115                 120                 125             


Ile Gly Leu Pro Pro Pro Thr Ala Ala Thr Gly Val Phe Ser Leu Lys 
    130                 135                 140                 


Ala Arg Pro Gly Leu Pro Pro Gly Ile Asn Val Ala Ser Leu Glu Trp 
145                 150                 155                 160 


Val Ser Arg Glu Pro Ala Leu Leu Cys Thr Phe Pro Arg Ser Gly Thr 
                165                 170                 175     


Pro Arg Lys Asp Ser Asn Leu Leu Ala Ala Pro Gln Gly Ser Tyr Pro 
            180                 185                 190         


Leu Leu Ala Asn Gly Val Cys Lys Trp Pro Gly Cys Glu Lys Ala Phe 
        195                 200                 205             


Glu Glu Pro Gly Glu Phe Leu Lys His Cys Gln Ala Asp His Leu Leu 
    210                 215                 220                 


Asp Glu Lys Gly Lys Ala Gln Cys Leu Leu Gln Arg Glu Val Val Gln 
225                 230                 235                 240 


Ser Leu Glu Gln Gln Leu Glu Leu Glu Lys Glu Lys Leu Gly Ala Met 
                245                 250                 255     


Gln Ala His Leu Ala Gly Lys Met Ala Leu Thr Lys Ala Pro Pro Val 
            260                 265                 270         


Ala Ser Val Asp Lys Ser Ser Cys Cys Leu Val Ala Thr Ser Thr Gln 
        275                 280                 285             


Gly Ser Val Leu Pro Ala Trp Ser Ser Pro Arg Glu Ala Ser Asp Ser 
    290                 295                 300                 


Leu Phe Ala Val Arg Arg His Leu Trp Gly Ser His Gly Asn Ser Thr 
305                 310                 315                 320 


Phe Pro Glu Phe Phe His Asn Met Asp Tyr Phe Lys Tyr His Asn Met 
                325                 330                 335     


Arg Pro Pro Phe Thr Tyr Ala Thr Leu Ile Arg Trp Ala Ile Leu Glu 
            340                 345                 350         


Ala Pro Glu Arg Gln Arg Thr Leu Asn Glu Ile Tyr His Trp Phe Thr 
        355                 360                 365             


Arg Met Phe Ala Tyr Phe Arg Asn His Pro Ala Thr Trp Lys Asn Ala 
    370                 375                 380                 


Ile Arg His Asn Leu Ser Leu His Lys Cys Phe Val Arg Val Glu Ser 
385                 390                 395                 400 


Glu Lys Gly Ala Val Trp Thr Val Asp Glu Phe Glu Phe Arg Lys Lys 
                405                 410                 415     


Arg Ser Gln Arg Pro Ser Lys Cys Ser Asn Pro Cys Pro 
            420                 425                 


<210>  8
<211>  819
<212>  DNA
<213>  Homo sapiens

<400>  8
atggattcat acctgctgat gtggggactg ctcacgttca tcatggtgcc tggctgccag       60

gcagagctct gtgacgatga cccgccagag atcccacacg ccacattcaa agccatggcc      120

tacaaggaag gaaccatgtt gaactgtgaa tgcaagagag gtttccgcag aataaaaagc      180

gggtcactct atatgctctg tacaggaaac tctagccact cgtcctggga caaccaatgt      240

caatgcacaa gctctgccac tcggaacaca acgaaacaag tgacacctca acctgaagaa      300

cagaaagaaa ggaaaaccac agaaatgcaa agtccaatgc agccagtgga ccaagcgagc      360

cttccaggtc actgcaggga acctccacca tgggaaaatg aagccacaga gagaatttat      420

catttcgtgg tggggcagat ggtttattat cagtgcgtcc agggatacag ggctctacac      480

agaggtcctg ctgagagcgt ctgcaaaatg acccacggga agacaaggtg gacccagccc      540

cagctcatat gcacaggtga aatggagacc agtcagtttc caggtgaaga gaagcctcag      600

gcaagccccg aaggccgtcc tgagagtgag acttcctgcc tcgtcacaac aacagatttt      660

caaatacaga cagaaatggc tgcaaccatg gagacgtcca tatttacaac agagtaccag      720

gtagcagtgg ccggctgtgt tttcctgctg atcagcgtcc tcctcctgag tgggctcacc      780

tggcagcgga gacagaggaa gagtagaaga acaatctag                             819


<210>  9
<211>  272
<212>  PRT
<213>  Homo sapiens

<400>  9

Met Asp Ser Tyr Leu Leu Met Trp Gly Leu Leu Thr Phe Ile Met Val 
1               5                   10                  15      


Pro Gly Cys Gln Ala Glu Leu Cys Asp Asp Asp Pro Pro Glu Ile Pro 
            20                  25                  30          


His Ala Thr Phe Lys Ala Met Ala Tyr Lys Glu Gly Thr Met Leu Asn 
        35                  40                  45              


Cys Glu Cys Lys Arg Gly Phe Arg Arg Ile Lys Ser Gly Ser Leu Tyr 
    50                  55                  60                  


Met Leu Cys Thr Gly Asn Ser Ser His Ser Ser Trp Asp Asn Gln Cys 
65                  70                  75                  80  


Gln Cys Thr Ser Ser Ala Thr Arg Asn Thr Thr Lys Gln Val Thr Pro 
                85                  90                  95      


Gln Pro Glu Glu Gln Lys Glu Arg Lys Thr Thr Glu Met Gln Ser Pro 
            100                 105                 110         


Met Gln Pro Val Asp Gln Ala Ser Leu Pro Gly His Cys Arg Glu Pro 
        115                 120                 125             


Pro Pro Trp Glu Asn Glu Ala Thr Glu Arg Ile Tyr His Phe Val Val 
    130                 135                 140                 


Gly Gln Met Val Tyr Tyr Gln Cys Val Gln Gly Tyr Arg Ala Leu His 
145                 150                 155                 160 


Arg Gly Pro Ala Glu Ser Val Cys Lys Met Thr His Gly Lys Thr Arg 
                165                 170                 175     


Trp Thr Gln Pro Gln Leu Ile Cys Thr Gly Glu Met Glu Thr Ser Gln 
            180                 185                 190         


Phe Pro Gly Glu Glu Lys Pro Gln Ala Ser Pro Glu Gly Arg Pro Glu 
        195                 200                 205             


Ser Glu Thr Ser Cys Leu Val Thr Thr Thr Asp Phe Gln Ile Gln Thr 
    210                 215                 220                 


Glu Met Ala Ala Thr Met Glu Thr Ser Ile Phe Thr Thr Glu Tyr Gln 
225                 230                 235                 240 


Val Ala Val Ala Gly Cys Val Phe Leu Leu Ile Ser Val Leu Leu Leu 
                245                 250                 255     


Ser Gly Leu Thr Trp Gln Arg Arg Gln Arg Lys Ser Arg Arg Thr Ile 
            260                 265                 270         


<210>  10
<211>  603
<212>  DNA
<213>  Homo sapiens

<400>  10
atggattcat acctgctgat gtggggactg ctcacgttca tcatggtgcc tggctgccag       60

gcagagctct gtgacgatga cccgccagag atcccacacg ccacattcaa agccatggcc      120

tacaaggaag gaaccatgtt gaactgtgaa tgcaagagag gtttccgcag aataaaaagc      180

gggtcactct atatgctctg tacaggaaac tctagccact cgtcctggga caaccaatgt      240

caatgcacaa gctctgccac tcggaacaca acgaaacaag tgacacctca acctgaagaa      300

cagaaagaaa ggaaaaccac agaaatgcaa agtccaatgc agccagtgga ccaagcgagc      360

cttccaggtg aagagaagcc tcaggcaagc cccgaaggcc gtcctgagag tgagacttcc      420

tgcctcgtca caacaacaga ttttcaaata cagacagaaa tggctgcaac catggagacg      480

tccatattta caacagagta ccaggtagca gtggccggct gtgttttcct gctgatcagc      540

gtcctcctcc tgagtgggct cacctggcag cggagacaga ggaagagtag aagaacaatc      600

tag                                                                    603


<210>  11
<211>  200
<212>  PRT
<213>  Homo sapiens

<400>  11

Met Asp Ser Tyr Leu Leu Met Trp Gly Leu Leu Thr Phe Ile Met Val 
1               5                   10                  15      


Pro Gly Cys Gln Ala Glu Leu Cys Asp Asp Asp Pro Pro Glu Ile Pro 
            20                  25                  30          


His Ala Thr Phe Lys Ala Met Ala Tyr Lys Glu Gly Thr Met Leu Asn 
        35                  40                  45              


Cys Glu Cys Lys Arg Gly Phe Arg Arg Ile Lys Ser Gly Ser Leu Tyr 
    50                  55                  60                  


Met Leu Cys Thr Gly Asn Ser Ser His Ser Ser Trp Asp Asn Gln Cys 
65                  70                  75                  80  


Gln Cys Thr Ser Ser Ala Thr Arg Asn Thr Thr Lys Gln Val Thr Pro 
                85                  90                  95      


Gln Pro Glu Glu Gln Lys Glu Arg Lys Thr Thr Glu Met Gln Ser Pro 
            100                 105                 110         


Met Gln Pro Val Asp Gln Ala Ser Leu Pro Gly Glu Glu Lys Pro Gln 
        115                 120                 125             


Ala Ser Pro Glu Gly Arg Pro Glu Ser Glu Thr Ser Cys Leu Val Thr 
    130                 135                 140                 


Thr Thr Asp Phe Gln Ile Gln Thr Glu Met Ala Ala Thr Met Glu Thr 
145                 150                 155                 160 


Ser Ile Phe Thr Thr Glu Tyr Gln Val Ala Val Ala Gly Cys Val Phe 
                165                 170                 175     


Leu Leu Ile Ser Val Leu Leu Leu Ser Gly Leu Thr Trp Gln Arg Arg 
            180                 185                 190         


Gln Arg Lys Ser Arg Arg Thr Ile 
        195                 200 


<210>  12
<211>  176
<212>  PRT
<213>  Homo sapiens

<400>  12

Met Asp Ser Tyr Leu Leu Met Trp Gly Leu Leu Thr Phe Ile Met Val 
1               5                   10                  15      


Pro Gly Cys Gln Ala Glu Leu Cys Asp Asp Asp Pro Pro Glu Ile Pro 
            20                  25                  30          


His Ala Thr Phe Lys Ala Met Ala Tyr Lys Glu Gly Thr Met Leu Asn 
        35                  40                  45              


Cys Glu Cys Lys Arg Gly Phe Arg Arg Ile Lys Ser Gly Ser Leu Tyr 
    50                  55                  60                  


Met Leu Cys Thr Gly Asn Ser Ser His Ser Ser Trp Asp Asn Gln Cys 
65                  70                  75                  80  


Gln Cys Thr Ser Ser Ala Thr Arg Asn Thr Thr Lys Gln Val Thr Pro 
                85                  90                  95      


Gln Pro Glu Glu Gln Lys Glu Arg Lys Thr Thr Glu Met Gln Ser Pro 
            100                 105                 110         


Met Gln Pro Val Asp Gln Ala Ser Leu Pro Asp Phe Gln Ile Gln Thr 
        115                 120                 125             


Glu Met Ala Ala Thr Met Glu Thr Ser Ile Phe Thr Thr Glu Tyr Gln 
    130                 135                 140                 


Val Ala Val Ala Gly Cys Val Phe Leu Leu Ile Ser Val Leu Leu Leu 
145                 150                 155                 160 


Ser Gly Leu Thr Trp Gln Arg Arg Gln Arg Lys Ser Arg Arg Thr Ile 
                165                 170                 175     


<210>  13
<211>  3218
<212>  DNA
<213>  Homo sapiens

<400>  13
agtttcctgg ctgaacacgc cagcccaata cttaaagaga gcaactcctg actccgatag       60

agactggatg gacccacaag ggtgacagcc caggcggacc gatcttccca tcccacatcc      120

tccggcgcga tgccaaaaag aggctgacgg caactgggcc ttctgcagag aaagacctcc      180

gcttcactgc cccggctggt cccaagggtc aggaagatgg attcatacct gctgatgtgg      240

ggactgctca cgttcatcat ggtgcctggc tgccaggcag agctctgtga cgatgacccg      300

ccagagatcc cacacgccac attcaaagcc atggcctaca aggaaggaac catgttgaac      360

tgtgaatgca agagaggttt ccgcagaata aaaagcgggt cactctatat gctctgtaca      420

ggaaactcta gccactcgtc ctgggacaac caatgtcaat gcacaagctc tgccactcgg      480

aacacaacga aacaagtgac acctcaacct gaagaacaga aagaaaggaa aaccacagaa      540

atgcaaagtc caatgcagcc agtggaccaa gcgagccttc caggtcactg cagggaacct      600

ccaccatggg aaaatgaagc cacagagaga atttatcatt tcgtggtggg gcagatggtt      660

tattatcagt gcgtccaggg atacagggct ctacacagag gtcctgctga gagcgtctgc      720

aaaatgaccc acgggaagac aaggtggacc cagccccagc tcatatgcac aggtgaaatg      780

gagaccagtc agtttccagg tgaagagaag cctcaggcaa gccccgaagg ccgtcctgag      840

agtgagactt cctgcctcgt cacaacaaca gattttcaaa tacagacaga aatggctgca      900

accatggaga cgtccatatt tacaacagag taccaggtag cagtggccgg ctgtgttttc      960

ctgctgatca gcgtcctcct cctgagtggg ctcacctggc agcggagaca gaggaagagt     1020

agaagaacaa tctagaaaac caaaagaaca agaatttctt ggtaagaagc cgggaacaga     1080

caacagaagt catgaagccc aagtgaaatc aaaggtgcta aatggtcgcc caggagacat     1140

ccgttgtgct tgcctgcgtt ttggaagctc tgaagtcaca tcacaggaca cggggcagtg     1200

gcaaccttgt ctctatgcca gctcagtccc atcagagagc gagcgctacc cacttctaaa     1260

tagcaatttc gccgttgaag aggaagggca aaaccactag aactctccat cttattttca     1320

tgtatatgtg ttcattaaag catgaatggt atggaactct ctccacccta tatgtagtat     1380

aaagaaaagt aggtttacat tcatctcatt ccaacttccc agttcaggag tcccaaggaa     1440

agccccagca ctaacgtaaa tacacaacac acacactcta ccctatacaa ctggacattg     1500

tctgcgtggt tcctttctca gccgcttctg actgctgatt ctcccgttca cgttgcctaa     1560

taaacatcct tcaagaactc tgggctgcta cccagaaatc attttaccct tggctcaatc     1620

ctctaagcta acccccttct actgagcctt cagtcttgaa tttctaaaaa acagaggcca     1680

tggcagaata atctttgggt aacttcaaaa cggggcagcc aaacccatga ggcaatgtca     1740

ggaacagaag gatgaatgag gtcccaggca gagaatcata cttagcaaag ttttacctgt     1800

gcgttactaa ttggcctctt taagagttag tttctttggg attgctatga atgataccct     1860

gaatttggcc tgcactaatt tgatgtttac aggtggacac acaaggtgca aatcaatgcg     1920

tacgtttcct gagaagtgtc taaaaacacc aaaaagggat ccgtacattc aatgtttatg     1980

caaggaagga aagaaagaag gaagtgaaga gggagaaggg atggaggtca cactggtaga     2040

acgtaaccac ggaaaagagc gcatcaggcc tggcacggtg gctcaggcct ataaccccag     2100

ctccctagga gaccaaggcg ggagcatctc ttgaggccag gagtttgaga ccagcctggg     2160

cagcatagca agacacatcc ctacaaaaaa ttagaaattg gctggatgtg gtggcatacg     2220

cctgtagtcc tagccactca ggaggctgag gcaggaggat tgcttgagcc caggagttcg     2280

aggctgcagt cagtcatgat ggcaccactg cactccagcc tgggcaacag agcaagatcc     2340

tgtctttaag gaaaaaaaga caagatgagc ataccagcag tccttgaaca ttatcaaaaa     2400

gttcagcata ttagaatcac cgggaggcct tgttaaaaga gttcgctggg cccatcttca     2460

gagtctctga gttgttggtc tggaatagag ccaaatgttt tgtgtgtcta acaattccca     2520

ggtgctgttg ctgctgctac tattccagga acacactttg agaaccattg tgttattgct     2580

ctgcacgccc acccactctc aactcccacg aaaaaaatca acttccagag ctaagatttc     2640

ggtggaagtc ctggttccat atctggtgca agatctcccc tcacgaatca gttgagtcaa     2700

cattctagct caacaacatc acacgattaa cattaacgaa aattattcat ttgggaaact     2760

atcagccagt tttcacttct gaaggggcag gagagtgtta tgagaaatca cggcagtttt     2820

cagcagggtc cagattcaga ttaaataact attttctgtc atttctgtga ccaaccacat     2880

acaaacagac tcatctgtgc actctccccc tcccccttca ggtatatgtt ttctgagtaa     2940

agttgaaaag aatctcagac cagaaaatat agatatatat ttaaatctta cttgagtaga     3000

actgattacg acttttgggt gttgaggggt ctataagatc aaaacttttc catgataata     3060

ctaagatgtt atcgaccatt tatctgtcct tctctcaaaa gtgtatggtg gaattttcca     3120

gaagctatgt gatacgtgat gatgtcatca ctctgctgtt aacatataat aaatttattg     3180

ctattgttta taaaagaata aatgatattt tttaaaaa                             3218


<210>  14
<211>  446
<212>  PRT
<213>  Artificial

<220>
<223>  Basiliximab Heavy Chain

<400>  14

Gln Leu Gln Gln Ser Gly Thr Val Leu Ala Arg Pro Gly Ala Ser Val 
1               5                   10                  15      


Lys Met Ser Cys Lys Ala Ser Gly Tyr Ser Phe Thr Arg Tyr Trp Met 
            20                  25                  30          


His Trp Ile Lys Gln Arg Pro Gly Gln Gly Leu Glu Trp Ile Gly Ala 
        35                  40                  45              


Ile Tyr Pro Gly Asn Ser Asp Thr Ser Tyr Asn Gln Lys Phe Glu Gly 
    50                  55                  60                  


Lys Ala Lys Leu Thr Ala Val Thr Ser Ala Ser Thr Ala Tyr Met Glu 
65                  70                  75                  80  


Leu Ser Ser Leu Thr His Glu Asp Ser Ala Val Tyr Tyr Cys Ser Arg 
                85                  90                  95      


Asp Tyr Gly Tyr Tyr Phe Asp Phe Trp Gly Gln Gly Thr Thr Leu Thr 
            100                 105                 110         


Val Ser Ser Ala Ser Thr Lys Gly Pro Ser Val Phe Pro Leu Ala Pro 
        115                 120                 125             


Ser Ser Lys Ser Thr Ser Gly Gly Thr Ala Ala Leu Gly Cys Leu Val 
    130                 135                 140                 


Lys Asp Tyr Phe Pro Glu Pro Val Thr Val Ser Trp Asn Ser Gly Ala 
145                 150                 155                 160 


Leu Thr Ser Gly Val His Thr Phe Pro Ala Val Leu Gln Ser Ser Gly 
                165                 170                 175     


Leu Tyr Ser Leu Ser Ser Val Val Thr Val Pro Ser Ser Ser Leu Gly 
            180                 185                 190         


Thr Gln Thr Tyr Ile Cys Asn Val Asn His Lys Pro Ser Asn Thr Lys 
        195                 200                 205             


Val Asp Lys Arg Val Glu Pro Pro Lys Ser Cys Asp Lys Thr His Thr 
    210                 215                 220                 


Cys Pro Pro Cys Pro Ala Pro Glu Leu Leu Gly Gly Pro Ser Val Phe 
225                 230                 235                 240 


Leu Phe Pro Pro Lys Pro Lys Asp Thr Leu Met Ile Ser Arg Thr Pro 
                245                 250                 255     


Glu Val Thr Cys Val Val Val Asp Val Ser His Glu Asp Pro Glu Val 
            260                 265                 270         


Lys Phe Asn Trp Tyr Val Asp Gly Val Glu Val His Asn Ala Lys Thr 
        275                 280                 285             


Lys Pro Arg Glu Glu Gln Tyr Asn Ser Thr Tyr Arg Val Val Ser Val 
    290                 295                 300                 


Leu Thr Val Leu His Gln Asp Trp Leu Asn Gly Lys Glu Tyr Lys Cys 
305                 310                 315                 320 


Lys Val Ser Asn Lys Ala Leu Pro Ala Pro Ile Glu Lys Thr Ile Ser 
                325                 330                 335     


Lys Ala Lys Gly Gln Pro Arg Glu Pro Gln Val Tyr Thr Leu Pro Pro 
            340                 345                 350         


Ser Arg Asp Glu Leu Thr Lys Asn Gln Val Ser Leu Thr Cys Leu Val 
        355                 360                 365             


Lys Gly Phe Tyr Pro Ser Asp Ile Ala Val Glu Trp Glu Ser Asn Gly 
    370                 375                 380                 


Gln Pro Glu Asn Asn Tyr Lys Thr Thr Pro Pro Val Leu Asp Ser Asp 
385                 390                 395                 400 


Gly Ser Phe Phe Leu Tyr Ser Lys Leu Thr Val Asp Lys Ser Arg Trp 
                405                 410                 415     


Gln Gln Gly Asn Val Phe Ser Cys Ser Val Met His Glu Ala Leu His 
            420                 425                 430         


Asn His Tyr Thr Gln Lys Ser Leu Ser Leu Ser Pro Gly Lys 
        435                 440                 445     


<210>  15
<211>  210
<212>  PRT
<213>  Artificial

<220>
<223>  Basiliximab Light Chain

<400>  15

Gln Ile Val Ser Thr Gln Ser Pro Ala Ile Met Ser Ala Ser Pro Gly 
1               5                   10                  15      


Glu Lys Val Thr Met Thr Cys Ser Ala Ser Ser Ser Arg Ser Tyr Met 
            20                  25                  30          


Gln Trp Tyr Gln Gln Lys Pro Gly Thr Ser Pro Lys Arg Trp Ile Tyr 
        35                  40                  45              


Asp Thr Ser Lys Leu Ala Ser Gly Val Pro Ala Arg Phe Ser Gly Ser 
    50                  55                  60                  


Gly Ser Gly Thr Ser Tyr Ser Leu Thr Ile Ser Ser Met Glu Ala Glu 
65                  70                  75                  80  


Asp Ala Ala Thr Tyr Tyr Cys His Gln Arg Ser Ser Tyr Thr Phe Gly 
                85                  90                  95      


Gly Gly Thr Lys Leu Glu Ile Lys Arg Thr Val Ala Ala Pro Ser Val 
            100                 105                 110         


Phe Ile Phe Pro Pro Ser Asp Glu Gln Leu Lys Ser Gly Thr Ala Ser 
        115                 120                 125             


Val Val Cys Leu Leu Asn Asn Phe Tyr Pro Arg Glu Ala Lys Val Gln 
    130                 135                 140                 


Trp Lys Val Asp Asn Ala Leu Gln Ser Gly Asn Ser Gln Glu Ser Val 
145                 150                 155                 160 


Thr Glu Gln Asp Ser Lys Asp Ser Thr Tyr Ser Leu Ser Ser Thr Leu 
                165                 170                 175     


Thr Leu Ser Lys Ala Asp Tyr Glu Lys His Lys Val Tyr Ala Cys Glu 
            180                 185                 190         


Val Thr His Gln Gly Leu Ser Ser Pro Val Thr Lys Ser Phe Asn Arg 
        195                 200                 205             


Gly Glu 
    210 


<210>  16
<211>  105
<212>  PRT
<213>  Homo sapiens

<400>  16

Ile Glu Val Met Tyr Pro Pro Pro Tyr Leu Asp Asn Glu Lys Ser Asn 
1               5                   10                  15      


Gly Thr Ile Ile His Val Lys Gly Lys His Leu Cys Pro Ser Pro Leu 
            20                  25                  30          


Phe Pro Gly Pro Ser Lys Pro Phe Trp Val Leu Val Val Val Gly Gly 
        35                  40                  45              


Val Leu Ala Cys Tyr Ser Leu Leu Val Thr Val Ala Phe Ile Ile Phe 
    50                  55                  60                  


Trp Val Arg Ser Lys Arg Ser Arg Leu Leu His Ser Asp Tyr Met Asn 
65                  70                  75                  80  


Met Thr Pro Arg Arg Pro Gly Pro Thr Arg Lys His Tyr Gln Pro Tyr 
                85                  90                  95      


Ala Pro Pro Arg Asp Phe Ala Ala Tyr 
            100                 105 


<210>  17
<211>  251
<212>  PRT
<213>  Homo sapiens

<400>  17

Glu Leu Cys Asp Asp Asp Pro Pro Glu Ile Pro His Ala Thr Phe Lys 
1               5                   10                  15      


Ala Met Ala Tyr Lys Glu Gly Thr Met Leu Asn Cys Glu Cys Lys Arg 
            20                  25                  30          


Gly Phe Arg Arg Ile Lys Ser Gly Ser Leu Tyr Met Leu Cys Thr Gly 
        35                  40                  45              


Asn Ser Ser His Ser Ser Trp Asp Asn Gln Cys Gln Cys Thr Ser Ser 
    50                  55                  60                  


Ala Thr Arg Asn Thr Thr Lys Gln Val Thr Pro Gln Pro Glu Glu Gln 
65                  70                  75                  80  


Lys Glu Arg Lys Thr Thr Glu Met Gln Ser Pro Met Gln Pro Val Asp 
                85                  90                  95      


Gln Ala Ser Leu Pro Gly His Cys Arg Glu Pro Pro Pro Trp Glu Asn 
            100                 105                 110         


Glu Ala Thr Glu Arg Ile Tyr His Phe Val Val Gly Gln Met Val Tyr 
        115                 120                 125             


Tyr Gln Cys Val Gln Gly Tyr Arg Ala Leu His Arg Gly Pro Ala Glu 
    130                 135                 140                 


Ser Val Cys Lys Met Thr His Gly Lys Thr Arg Trp Thr Gln Pro Gln 
145                 150                 155                 160 


Leu Ile Cys Thr Gly Glu Met Glu Thr Ser Gln Phe Pro Gly Glu Glu 
                165                 170                 175     


Lys Pro Gln Ala Ser Pro Glu Gly Arg Pro Glu Ser Glu Thr Ser Cys 
            180                 185                 190         


Leu Val Thr Thr Thr Asp Phe Gln Ile Gln Thr Glu Met Ala Ala Thr 
        195                 200                 205             


Met Glu Thr Ser Ile Phe Thr Thr Glu Tyr Gln Val Ala Val Ala Gly 
    210                 215                 220                 


Cys Val Phe Leu Leu Ile Ser Val Leu Leu Leu Ser Gly Leu Thr Trp 
225                 230                 235                 240 


Gln Arg Arg Gln Arg Lys Ser Arg Arg Thr Ile 
                245                 250     


