                               SEQUENCE LISTING

<110> AMAZON TECHNOLOGIES, INC.
 
<120> NUCLEASES FOR SIGNAL AMPLIFICATION

<130> 146401.091762

<140>
<141>

<150> 63/175,236
<151> 2021-04-15

<160> 22    

<170> PatentIn version 3.5

<210> 1
<211> 472
<212> PRT
<213> Sulfolobus islandicus

<400> 1
Ala Ala His His His His His His Ser Ser Gly Leu Val Pro Arg Gly 
1               5                   10                  15      


Ser His Met Lys Cys Leu Phe Tyr Ile Ala Gly Asp Val Ser Asn Tyr 
            20                  25                  30          


Ser Ile Val Asn Tyr Glu Leu Asn Gly Gln Thr Gln Asn Thr Phe Phe 
        35                  40                  45              


Ala Ala His Ala Leu Tyr Asn Leu Phe Lys Pro Asp Lys Val Ile Ala 
    50                  55                  60                  


Leu Ile Pro Asp Ser Leu Val Lys Asp Asn Val Ser Asp Glu Glu Cys 
65                  70                  75                  80  


Tyr Lys Asn Leu Val Ile Asn Arg Ala Lys Glu Leu Asn Phe Ala Gly 
                85                  90                  95      


Met Glu Glu Phe Met Asn Lys Val Glu Ile Arg Lys Ile Pro Asn Val 
            100                 105                 110         


Gly Ile Ala Ser Ala Ile Gln Cys Glu Asn Gly Ala Pro Lys Lys Glu 
        115                 120                 125             


Lys Asn Lys Glu Gly Arg Glu Val Leu Lys Arg Leu Pro Tyr Asn Glu 
    130                 135                 140                 


Lys Arg Ser Pro Ile Phe Ile Phe Asn Ala Ile Tyr Ala Ile Phe Lys 
145                 150                 155                 160 


Asp Glu Ala Cys Asp Glu Tyr Leu Val Asp Leu Thr His Gly Thr Asn 
                165                 170                 175     


Val Leu Val Ser Ile Gly Met Asn Val Gly Ala Leu Phe Asn Ala Lys 
            180                 185                 190         


Phe Tyr Ser Ala Pro Val Met Gly Met Pro Gly Lys Asp Ser Ile Val 
        195                 200                 205             


Asn Ile Val Glu Leu Thr Asp Val Val Gln Ala Thr Asn Asp Ser Leu 
    210                 215                 220                 


Met Ile Arg Ser Ser Ile Glu Asn Leu Asp Glu Arg Tyr Phe Lys Asp 
225                 230                 235                 240 


Tyr Ser Ala Lys Leu Ser Arg Leu Asn Pro Thr Ile Phe Glu Glu Glu 
                245                 250                 255     


Glu Lys Lys Val Leu Thr Arg Val Lys Gly Thr Asp Val Asn Val Val 
            260                 265                 270         


Ile Asn Phe Leu Trp Asn Ile Arg Asn Gly Phe Thr Val Asn Ala Val 
        275                 280                 285             


Lys Ser Met Asn Glu Leu Lys Asn Ile Ile Asn Gln Leu Glu Glu Asp 
    290                 295                 300                 


Leu Glu Lys Leu Lys Ser Phe Tyr Lys Asn Trp Glu Glu His Lys Asn 
305                 310                 315                 320 


Phe Gln Gly Glu Thr Leu Leu Val Leu Ser Asp Leu Asp Ser Thr Leu 
                325                 330                 335     


Lys Val Lys Asp Leu Leu Ile Glu Gly Asn Asp Leu Glu Lys Leu Asn 
            340                 345                 350         


Tyr Leu Leu Asp Leu Tyr Ile Lys Ala Ser Ile Tyr Asp Lys Ala Leu 
        355                 360                 365             


Ser Leu Ala Arg Glu Leu Pro Val Ala Ile Cys Leu Asn Lys Val Gly 
    370                 375                 380                 


Gly Gly Met Phe Asp Asp Lys Asn Glu Lys Tyr Lys His Cys Asn Glu 
385                 390                 395                 400 


Ile Val Thr Ser Tyr Leu Arg Leu Arg Tyr Ser Gly Leu Met Glu Phe 
                405                 410                 415     


Arg Asn Thr Leu Met His Gly Gly Leu Ser Thr Asp Met Lys Pro Asn 
            420                 425                 430         


Val Asp Lys Asp Gly Asn Ile Thr Pro Gly Lys Ile Val Thr Lys Asn 
        435                 440                 445             


Lys Ile Glu Asp Phe Val Lys Arg Glu Leu Arg Asn Tyr Phe Asp Lys 
    450                 455                 460                 


Ile Val Asn Phe Leu Ser Ser Ala 
465                 470         


<210> 2
<211> 241
<212> PRT
<213> Escherichia coli

<400> 2
Met Ser Asp Trp Ser Leu Ser Gln Leu Phe Ala Ser Leu His Glu Asp 
1               5                   10                  15      


Ile Gln Leu Arg Leu Gly Thr Ala Arg Lys Ala Phe Gln His Pro Gly 
            20                  25                  30          


Ala Lys Gly Asp Ala Ser Glu Gly Val Trp Ile Glu Met Leu Asp Thr 
        35                  40                  45              


Tyr Leu Pro Lys Arg Tyr Gln Ala Ala Asn Ala Phe Val Val Asp Ser 
    50                  55                  60                  


Leu Gly Asn Phe Ser Asp Gln Ile Asp Val Val Val Phe Asp Arg Gln 
65                  70                  75                  80  


Tyr Ser Pro Phe Ile Phe Lys Phe Asn Glu Gln Ile Ile Val Pro Ala 
                85                  90                  95      


Glu Ser Val Tyr Ala Val Phe Glu Ala Lys Gln Ser Ala Ser Ala Asp 
            100                 105                 110         


Leu Val Ala Tyr Ala Gln Arg Lys Val Ala Ser Val Arg Arg Leu His 
        115                 120                 125             


Arg Thr Ser Leu Pro Ile Pro His Ala Gly Gly Thr Tyr Pro Ala Lys 
    130                 135                 140                 


Pro Leu Ile Pro Ile Leu Gly Gly Leu Leu Thr Phe Glu Ser Asp Trp 
145                 150                 155                 160 


Ser Pro Ala Leu Gly Met Ser Phe Asp Lys Ala Leu Asn Gly Asp Leu 
                165                 170                 175     


Ser Asp Gly Arg Leu Asp Met Gly Cys Val Ala Ser His Gly His Phe 
            180                 185                 190         


Tyr Phe Asn Asn Ile Asp Ser Lys Phe Asn Phe Glu His Gly Asn Lys 
        195                 200                 205             


Pro Ala Thr Ala Phe Leu Phe Arg Leu Ile Ala Gln Leu Gln Phe Ser 
    210                 215                 220                 


Gly Thr Val Pro Met Ile Asp Ile Asp Ala Tyr Gly Lys Trp Leu Ala 
225                 230                 235                 240 


Asn 
    


<210> 3
<211> 636
<212> PRT
<213> Thermus thermophilus

<400> 3
Met Gln Ala Pro Val Tyr Leu Cys Leu Leu Gly Asn Asp Pro Ala Pro 
1               5                   10                  15      


Ala Tyr Leu Gly Leu Lys Val Val Glu Arg Glu Ala Gly Arg Val Ala 
            20                  25                  30          


Lys Ala Val Phe Tyr Ser Phe Pro Ala Trp Asn Glu Glu Tyr Gly Lys 
        35                  40                  45              


Lys Arg Gln Ala Phe Phe Arg Leu Leu Ser Glu Lys Gly Val Leu Tyr 
    50                  55                  60                  


Glu Glu Arg Pro Leu Glu Lys Gly Leu Glu Glu Ala Glu Ala Arg Glu 
65                  70                  75                  80  


Val Trp Val Asn Leu Thr Gly Gly Ala Lys Tyr Trp Ala Val Arg Phe 
                85                  90                  95      


Leu Gly His Trp Arg Arg Pro Gly Ala Arg Val Phe Leu Val Glu Gly 
            100                 105                 110         


His Arg Ala Leu Glu Ala Pro Arg Ala Leu Phe Leu Trp Pro Arg Glu 
        115                 120                 125             


Glu Glu Arg Ser Leu Glu Ala Glu Ala Leu Thr Leu Glu Glu Tyr Ala 
    130                 135                 140                 


Arg Leu Tyr Leu Glu Pro Leu Gly Glu Ala Trp Glu Arg Val Ser Pro 
145                 150                 155                 160 


Pro Gly Ala Phe Pro Pro Gly Ala Gln Ala Ala Arg Leu Pro Gly Arg 
                165                 170                 175     


Glu Gly Gly Val Phe Val Val His Arg Gly Leu Pro Tyr Trp Tyr Trp 
            180                 185                 190         


Val Arg Pro His Leu Gly Gly Glu Ala Lys Asp Met Ser Arg Lys Ala 
        195                 200                 205             


Leu Ser Ala Phe Ser Gly Glu Ala Lys Arg Leu Gly Gly Gln Leu Cys 
    210                 215                 220                 


Leu Pro Val Val Pro Tyr His Lys Ala His Leu Arg Ser Arg His Pro 
225                 230                 235                 240 


Lys Glu Arg Glu Asn Val Phe Ala Arg Trp Arg Ala Trp Ala Arg Glu 
                245                 250                 255     


Tyr Gly Val Phe Leu Val Asp Pro Gly Arg Pro Leu Glu Glu Glu Val 
            260                 265                 270         


Ala Ser Leu Ile Lys Gly Lys Ala Ser Lys Lys Ala Leu Pro Leu Pro 
        275                 280                 285             


Gln Glu Gly Pro Leu Leu Leu Ala Leu Val Ser Glu Gln Ala Val Pro 
    290                 295                 300                 


Leu Tyr Ala Ala Tyr Leu His Ala Gly Pro Arg Glu Val Tyr Leu Leu 
305                 310                 315                 320 


Thr Thr Pro Glu Met Glu Ser Arg Leu Arg Trp Ala Glu Ala Phe Phe 
                325                 330                 335     


Arg Gly Lys Gly Val Arg Val His Arg Ser Phe Leu Ser Gly Pro Trp 
            340                 345                 350         


Ala Leu Arg Glu Val Arg Asp Leu Leu Ala Pro Val Val Glu Glu Ala 
        355                 360                 365             


Leu Arg Arg Gly His Pro Val His Ala Asn Leu Asn Ser Gly Thr Thr 
    370                 375                 380                 


Ala Met Ala Leu Gly Leu Tyr Leu Ala Leu Arg Asp Gly Ala Arg Ala 
385                 390                 395                 400 


His Tyr Leu Asp Gly Asp Arg Leu Leu Leu Leu Asp Gly Gly Glu Ala 
                405                 410                 415     


Glu Val Pro Trp Glu Glu Gly Arg Pro Glu Asp Leu Leu Ala Leu Arg 
            420                 425                 430         


Gly Tyr Arg Phe Glu Glu Glu Tyr Pro Asp Ala Arg Pro Asp Pro Gly 
        435                 440                 445             


Leu Leu Ala Leu Ala Glu Glu Ile Leu Arg Arg Trp Asp Glu Val Gln 
    450                 455                 460                 


Thr Ser Trp Glu Ala Ser Pro Leu Val Arg Arg Phe Leu Lys Phe Trp 
465                 470                 475                 480 


Lys Lys Arg Phe Gly Gln Ala Phe Pro Pro Lys Arg Leu Ser Arg Leu 
                485                 490                 495     


Lys Gly Leu Pro Leu Glu Tyr Ala Val Tyr Ser His Leu Asn Ala His 
            500                 505                 510         


Leu Ala Pro Lys Gly Gly Gln Ala Arg Met Gly Gly His Leu Val Pro 
        515                 520                 525             


Leu Gly Gly Asn Glu Ala Leu Ala Pro Gln Ser Thr Glu Val Asp Gly 
    530                 535                 540                 


Val Phe Phe His Arg Gly Ala Leu Trp Phe Val Glu Cys Lys Pro Thr 
545                 550                 555                 560 


Asp Glu Gly Leu Arg Glu Arg Ala Pro Ile Met Ala Glu Leu Val Arg 
                565                 570                 575     


Ser Val Gly Gly Val Glu Ala Arg Gly Leu Met Val Ala Arg Arg Trp 
            580                 585                 590         


Arg Gly Ala Pro Pro Pro Ala Ser Pro Asn Leu Val Tyr Met Ala Leu 
        595                 600                 605             


Glu Gly Gly Glu Gly Val Gly Val Tyr Arg Phe Pro Glu Glu Leu Glu 
    610                 615                 620                 


Lys Ala Leu Ser Arg Asn Pro Ala Pro Arg Arg Gly 
625                 630                 635     


<210> 4
<211> 462
<212> PRT
<213> Acinetobacter baumannii

<400> 4
Met Ser Ala Ser Leu Leu Glu Lys Gln Ser Thr Gly Gly Ala Ile Ala 
1               5                   10                  15      


Arg Val Gly Phe Gly Tyr Gln Asp Ala Phe Val Leu Arg Ser Leu Pro 
            20                  25                  30          


Leu Trp Leu Ser Gln Ser Ala Phe Ser His Ile Val Ser Glu Ala Leu 
        35                  40                  45              


Ser Asp Ile Glu Val Cys Tyr Phe Ser Ser Glu Lys Ser Leu His Val 
    50                  55                  60                  


Met Tyr Glu Ala Lys Asn His Ser Leu Thr Ala Thr Glu Phe Trp Asp 
65                  70                  75                  80  


Glu Ile Arg Arg Phe Lys Ser Leu Phe Asp Thr His Pro Lys Asn Phe 
                85                  90                  95      


Ile Trp Phe Asn Leu Val Cys Pro Ser Tyr Asn Thr Ala Ile Ser Pro 
            100                 105                 110         


Leu Ile Ser Lys Ile Asp Arg Leu Arg Gly Val Gly Ser Ser Tyr Asp 
        115                 120                 125             


Asp Asp Ser Ser Val Ser Val Asn Gly Arg Ser Glu Tyr Leu Asp Trp 
    130                 135                 140                 


Cys Val Gly Lys Lys Ile Asp Phe Ser Leu Ala Glu Phe Ala Leu Asp 
145                 150                 155                 160 


Tyr Val Gly Phe Ile Thr Phe Asn Ser Glu Asn Ser Glu Ser Ile Phe 
                165                 170                 175     


Leu Ser Glu Ile Gln Asp Thr Ile Asn Ile Glu Leu Leu Arg Ser Gln 
            180                 185                 190         


Val Lys Gln Leu Lys Asp Gln Phe Lys Asn Leu Ile Ser Arg Ser Ser 
        195                 200                 205             


Phe Gly Pro Ile Tyr Arg Lys Asp Phe Glu Asn Phe Ile Cys His Ala 
    210                 215                 220                 


Leu Glu Glu Asp Arg Ser Gln Trp Leu Leu Asp Pro Ile Lys Ile Asn 
225                 230                 235                 240 


Leu Ser Ala Ser Ser Ser Gln Tyr Gln Asp Leu Asn Leu Asp Ile Ser 
                245                 250                 255     


Asp Phe Asn Gly Pro Asp Arg Ala Gln Lys Thr Ser Ser Asp Trp Asn 
            260                 265                 270         


Ser Leu Ile Lys Lys Ala Val Ser Ile Gly Asp Phe Ile His Asn Ser 
        275                 280                 285             


Gly Asp Arg Arg Thr Leu Leu Ile Asp Gly Lys Gln Arg Met Ser Thr 
    290                 295                 300                 


Ala Cys Met Leu Gly Tyr Val Phe Ser Ala Thr Arg Asn Phe Leu Leu 
305                 310                 315                 320 


Glu Ile Glu His Asn Gly Leu Ile Tyr Arg Thr Asp Asp His Lys Gln 
                325                 330                 335     


Lys Glu Gly Gln Phe Phe Thr Lys Ile Glu Ala Val Glu Pro Gln Gly 
            340                 345                 350         


Glu Thr Glu Ala Ile Val Ala Ile Gly Phe Pro Thr Ala Ile Gly Lys 
        355                 360                 365             


Asp Ile Asp Ser Thr Ile Asn Glu Val Lys Ser Leu Pro Arg Leu Asn 
    370                 375                 380                 


Leu Glu Ser Ser His Ala Ile Asp Asn Met Glu Thr Leu Asn Leu Ala 
385                 390                 395                 400 


Val Arg Glu Ala Lys Ser Ala Leu Val Ser Phe Lys Ser Glu Asn Lys 
                405                 410                 415     


Leu Ser Lys Leu His Leu Phe Ile Lys Ala Pro Ser Val Phe Ala Met 
            420                 425                 430         


Val Leu Gly His Arg Leu Asn Gly Ile Cys Asp Ile Gln Leu Tyr Asp 
        435                 440                 445             


Trp Val Asp Gly Gln Tyr Ile Pro Thr Ala Glu Leu Asn Leu 
    450                 455                 460         


<210> 5
<211> 499
<212> PRT
<213> Enterobacter cloacae

<400> 5
Met Ala Thr Ser Val Leu Ala Asn Trp His Gly His Asp Tyr Gln Ala 
1               5                   10                  15      


Arg Tyr Phe Trp Ile Glu Ala Ser Arg Leu Lys Asn Pro Gln Gln Asp 
            20                  25                  30          


Phe Val Val Glu Val Ser Tyr Glu Ala Asp Gly Pro Lys Ala Phe Asp 
        35                  40                  45              


Asp Val Ile Thr Arg Tyr Asn Pro Pro Arg Arg Ser Thr Gly Pro Asp 
    50                  55                  60                  


Arg Ile Gln Ala Asp Tyr Tyr Gln Ile Lys Phe His Val Thr Gln Ala 
65                  70                  75                  80  


Ala Ser Phe Gly Phe Glu Asp Leu Ile Asp Pro Ala Phe Ile Gly Ala 
                85                  90                  95      


Glu Thr Phe Ser Ile Leu Glu Arg Leu Lys Gln Ala Lys Gly Thr Glu 
            100                 105                 110         


Pro Ala Asn Ser Ala Phe His Leu Val Thr Thr Asp Arg Ile Ile Asp 
        115                 120                 125             


Glu Asp Pro Leu Gly Glu Ile Ile Ser Asn Val Asp Gly Ser Ile Arg 
    130                 135                 140                 


Leu Asp Lys Leu Phe Asp Gly Thr Thr Asp Arg Ser Arg Lys Gly Lys 
145                 150                 155                 160 


Val Arg Lys Leu Trp Arg Gln His Leu Lys Leu Ser Thr Asp Gln Glu 
                165                 170                 175     


Leu Glu Gln Val Leu Ser Gly Phe His Ile Gln Gln Ser Gln Pro Thr 
            180                 185                 190         


Leu Glu Ala Met Arg Glu Lys Val Asn Thr Cys Phe Gln Ile Ile Gly 
        195                 200                 205             


Leu Ile Thr Cys Glu Thr Ser Ser Asp Phe Arg Phe Asp Gly Ala Ala 
    210                 215                 220                 


Arg Ala Leu Arg Ser Gln Glu Arg Tyr Arg Phe Thr Arg Glu Gln Phe 
225                 230                 235                 240 


Thr Ala Leu Cys Glu Glu Glu Asn Trp Ile Arg Ser Glu Ala Pro Glu 
                245                 250                 255     


Ser Phe Arg Asn Val Ala Leu Arg Ser Phe Ser Asp Gly Pro Leu Asp 
            260                 265                 270         


Ile Met Asp Ala Leu Pro Glu His Thr Leu Ser Leu Leu Ser Leu Phe 
        275                 280                 285             


Glu Gly Arg Phe Pro Ser Pro Gly Ile Glu Trp Asn Asp Val Ile Lys 
    290                 295                 300                 


Pro Gln Val Glu Thr Phe Leu Thr Gly Ile Arg Gln Thr Glu Arg Lys 
305                 310                 315                 320 


Val Arg Leu Tyr Leu Asn Thr His Ser Ser Ile Ala Met Leu Ala Gly 
                325                 330                 335     


Lys Cys Leu Gly His Lys Ser Gly Val Glu Ile Glu Leu Val Gln Lys 
            340                 345                 350         


Gly Arg Met Gly Asp Ser Ile Trp Ser Glu Asn Glu Ser Gln Asp Glu 
        355                 360                 365             


Pro Asp Ala Val Ile Glu Thr Glu Thr Val Gly Thr Gly Ser Asp Val 
    370                 375                 380                 


Ala Val Val Leu Ser Ile Thr Arg Asn Ala Leu Pro Lys Ala Arg Ala 
385                 390                 395                 400 


Tyr Ile Leu Glu Asn Gln Pro Asp Ile Gly Arg Ile Ile His Val Thr 
                405                 410                 415     


Pro Ala Asn Gly His Gly Gln Arg Ser Val Lys Asn Gly Ser His Ala 
            420                 425                 430         


Val Ala Ile Ala Glu Gln Val Ser Asp Val Val Met Asp Ala Asp Leu 
        435                 440                 445             


Pro Val Glu Ala Ser Leu His Ile Phe Ser Ala Ala Pro Asn Ala Val 
    450                 455                 460                 


Asn Phe Tyr Leu Gly Gln His Thr Asp Phe Leu Gly Thr Cys Val Phe 
465                 470                 475                 480 


Tyr Glu Phe Asp Phe Gln Arg Gln Arg Asp Gly Ser Tyr Leu Pro Ser 
                485                 490                 495     


Phe Lys Val 
            


<210> 6
<211> 1281
<212> PRT
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: 
      Synthetic polypeptide

<400> 6
Met Lys Lys Ser Ile Phe Asp Gln Phe Val Asn Gln Tyr Ala Leu Ser 
1               5                   10                  15      


Lys Thr Leu Arg Phe Glu Leu Lys Pro Val Gly Glu Thr Gly Arg Met 
            20                  25                  30          


Leu Glu Glu Ala Lys Val Phe Ala Lys Asp Glu Thr Ile Lys Lys Lys 
        35                  40                  45              


Tyr Glu Ala Thr Lys Pro Phe Phe Asn Lys Leu His Arg Glu Phe Val 
    50                  55                  60                  


Glu Glu Ala Leu Asn Glu Val Glu Leu Ala Gly Leu Pro Glu Tyr Phe 
65                  70                  75                  80  


Glu Ile Phe Lys Tyr Trp Lys Arg Tyr Lys Lys Lys Phe Glu Lys Asp 
                85                  90                  95      


Leu Gln Lys Lys Glu Lys Glu Leu Arg Lys Ser Val Val Gly Phe Phe 
            100                 105                 110         


Asn Ala Gln Ala Lys Glu Trp Ala Lys Lys Tyr Glu Thr Leu Gly Val 
        115                 120                 125             


Lys Lys Lys Asp Val Gly Leu Leu Phe Glu Glu Asn Val Phe Ala Ile 
    130                 135                 140                 


Leu Lys Glu Arg Tyr Gly Asn Glu Glu Gly Ser Gln Ile Val Asp Glu 
145                 150                 155                 160 


Ser Thr Gly Lys Asp Val Ser Ile Phe Asp Ser Trp Lys Gly Phe Thr 
                165                 170                 175     


Gly Tyr Phe Ile Lys Phe Gln Glu Thr Arg Lys Asn Phe Tyr Lys Asp 
            180                 185                 190         


Asp Gly Thr Ala Thr Ala Leu Ala Thr Arg Ile Ile Asp Gln Asn Leu 
        195                 200                 205             


Lys Arg Phe Cys Asp Asn Leu Leu Ile Phe Glu Ser Ile Arg Asp Lys 
    210                 215                 220                 


Ile Asp Phe Ser Glu Val Glu Gln Thr Met Gly Asn Ser Ile Asp Lys 
225                 230                 235                 240 


Val Phe Ser Val Ile Phe Tyr Ser Ser Cys Leu Leu Gln Glu Gly Ile 
                245                 250                 255     


Asp Phe Tyr Asn Cys Val Leu Gly Gly Glu Thr Leu Pro Asn Gly Glu 
            260                 265                 270         


Lys Arg Gln Gly Ile Asn Glu Leu Ile Asn Leu Tyr Arg Gln Lys Thr 
        275                 280                 285             


Ser Glu Lys Val Pro Phe Leu Lys Leu Leu Asp Lys Gln Ile Leu Ser 
    290                 295                 300                 


Glu Lys Glu Lys Phe Met Asp Glu Ile Glu Asn Asp Glu Ala Leu Leu 
305                 310                 315                 320 


Asp Thr Leu Lys Ile Phe Arg Lys Ser Ala Glu Glu Lys Thr Thr Leu 
                325                 330                 335     


Leu Lys Asn Ile Phe Gly Asp Phe Val Met Asn Gln Gly Lys Tyr Asp 
            340                 345                 350         


Leu Ala Gln Ile Tyr Ile Ser Arg Glu Ser Leu Asn Thr Ile Ser Arg 
        355                 360                 365             


Lys Trp Thr Ser Glu Thr Asp Ile Phe Glu Asp Ser Leu Tyr Glu Val 
    370                 375                 380                 


Leu Lys Lys Ser Lys Ile Val Ser Ala Ser Val Lys Lys Lys Asp Gly 
385                 390                 395                 400 


Gly Tyr Ala Phe Pro Glu Phe Ile Ala Leu Ile Tyr Val Lys Ser Ala 
                405                 410                 415     


Leu Glu Gln Ile Pro Thr Glu Lys Phe Trp Lys Glu Arg Tyr Tyr Lys 
            420                 425                 430         


Asn Ile Gly Asp Val Leu Asn Lys Gly Phe Leu Asn Gly Lys Glu Gly 
        435                 440                 445             


Val Trp Leu Gln Phe Leu Leu Ile Phe Asp Phe Glu Phe Asn Ser Leu 
    450                 455                 460                 


Phe Glu Arg Glu Ile Ile Asp Glu Asn Gly Asp Lys Lys Val Ala Gly 
465                 470                 475                 480 


Tyr Asn Leu Phe Ala Lys Gly Phe Asp Asp Leu Leu Asn Asn Phe Lys 
                485                 490                 495     


Tyr Asp Gln Lys Ala Lys Val Val Ile Lys Asp Phe Ala Asp Glu Val 
            500                 505                 510         


Leu His Ile Tyr Gln Met Gly Lys Tyr Phe Ala Ile Glu Lys Lys Arg 
        515                 520                 525             


Ser Trp Leu Ala Asp Tyr Asp Ile Asp Ser Phe Tyr Thr Asp Pro Glu 
    530                 535                 540                 


Lys Gly Tyr Leu Lys Phe Tyr Glu Asn Ala Tyr Glu Glu Ile Ile Gln 
545                 550                 555                 560 


Val Tyr Asn Lys Leu Arg Asn Tyr Leu Thr Lys Lys Pro Tyr Ser Glu 
                565                 570                 575     


Asp Lys Trp Lys Leu Asn Phe Glu Asn Pro Thr Leu Ala Asp Gly Trp 
            580                 585                 590         


Asp Lys Asn Lys Glu Ala Asp Asn Ser Thr Val Ile Leu Lys Lys Asp 
        595                 600                 605             


Gly Arg Tyr Tyr Leu Gly Leu Met Ala Arg Gly Arg Asn Lys Leu Phe 
    610                 615                 620                 


Asp Asp Arg Asn Leu Pro Lys Ile Leu Glu Gly Val Glu Asn Gly Lys 
625                 630                 635                 640 


Tyr Glu Lys Val Val Tyr Lys Tyr Phe Pro Asp Gln Ala Lys Met Phe 
                645                 650                 655     


Pro Lys Val Cys Phe Ser Thr Lys Gly Leu Glu Phe Phe Gln Pro Ser 
            660                 665                 670         


Glu Glu Val Ile Thr Ile Tyr Lys Asn Ser Glu Phe Lys Lys Gly Tyr 
        675                 680                 685             


Thr Phe Asn Val Arg Ser Met Gln Arg Leu Ile Asp Phe Tyr Lys Asp 
    690                 695                 700                 


Cys Leu Val Arg Tyr Glu Gly Trp Gln Cys Tyr Asp Phe Arg Asn Leu 
705                 710                 715                 720 


Arg Lys Thr Glu Asp Tyr Arg Lys Asn Ile Glu Glu Phe Phe Ser Asp 
                725                 730                 735     


Val Ala Met Asp Gly Tyr Lys Ile Ser Phe Gln Asp Val Ser Glu Ser 
            740                 745                 750         


Tyr Ile Lys Glu Lys Asn Gln Asn Gly Asp Leu Tyr Leu Phe Glu Ile 
        755                 760                 765             


Lys Asn Lys Asp Trp Asn Glu Gly Ala Asn Gly Lys Lys Asn Leu His 
    770                 775                 780                 


Thr Ile Tyr Phe Glu Ser Leu Phe Ser Ala Asp Asn Ile Ala Met Asn 
785                 790                 795                 800 


Phe Pro Val Lys Leu Asn Gly Gln Ala Glu Ile Phe Tyr Arg Pro Arg 
                805                 810                 815     


Thr Glu Gly Leu Glu Lys Glu Arg Ile Ile Thr Lys Lys Gly Asn Val 
            820                 825                 830         


Leu Glu Lys Gly Asp Lys Ala Phe His Lys Arg Arg Tyr Thr Glu Asn 
        835                 840                 845             


Lys Val Phe Phe His Val Pro Ile Thr Leu Asn Arg Thr Lys Lys Asn 
    850                 855                 860                 


Pro Phe Gln Phe Asn Ala Lys Ile Asn Asp Phe Leu Ala Lys Asn Ser 
865                 870                 875                 880 


Asp Ile Asn Val Ile Gly Val Asp Arg Gly Glu Lys Gln Leu Ala Tyr 
                885                 890                 895     


Phe Ser Val Ile Ser Gln Arg Gly Lys Ile Leu Asp Arg Gly Ser Leu 
            900                 905                 910         


Asn Val Ile Asn Gly Val Asn Tyr Ala Glu Lys Leu Glu Glu Lys Ala 
        915                 920                 925             


Arg Gly Arg Glu Gln Ala Arg Lys Asp Trp Gln Gln Ile Glu Gly Ile 
    930                 935                 940                 


Lys Asp Leu Lys Lys Gly Tyr Ile Ser Gln Val Val Arg Lys Leu Ala 
945                 950                 955                 960 


Asp Leu Ala Ile Gln Tyr Asn Ala Ile Ile Val Phe Glu Asp Leu Asn 
                965                 970                 975     


Met Arg Phe Lys Gln Ile Arg Gly Gly Ile Glu Lys Ser Val Tyr Gln 
            980                 985                 990         


Gln Leu Glu Lys Ala Leu Ile Asp  Lys Leu Thr Phe Leu  Val Glu Lys 
        995                 1000                 1005             


Glu Glu  Lys Asp Val Glu Lys  Ala Gly His Leu Leu  Lys Ala Tyr 
    1010                 1015                 1020             


Gln Leu  Ala Ala Pro Phe Glu  Thr Phe Gln Lys Met  Gly Lys Gln 
    1025                 1030                 1035             


Thr Gly  Ile Val Phe Tyr Thr  Gln Ala Ala Tyr Thr  Ser Arg Ile 
    1040                 1045                 1050             


Asp Pro  Val Thr Gly Trp Arg  Pro His Leu Tyr Leu  Lys Tyr Ser 
    1055                 1060                 1065             


Ser Ala  Glu Lys Ala Lys Ala  Asp Leu Leu Lys Phe  Lys Lys Ile 
    1070                 1075                 1080             


Lys Phe  Val Asp Gly Arg Phe  Glu Phe Thr Tyr Asp  Ile Lys Ser 
    1085                 1090                 1095             


Phe Arg  Glu Gln Lys Glu His  Pro Lys Ala Thr Val  Trp Thr Val 
    1100                 1105                 1110             


Cys Ser  Cys Val Glu Arg Phe  Arg Trp Asn Arg Tyr  Leu Asn Ser 
    1115                 1120                 1125             


Asn Lys  Gly Gly Tyr Asp His  Tyr Ser Asp Val Thr  Lys Phe Leu 
    1130                 1135                 1140             


Val Glu  Leu Phe Gln Glu Tyr  Gly Ile Asp Phe Glu  Arg Gly Asp 
    1145                 1150                 1155             


Ile Val  Gly Gln Ile Glu Val  Leu Glu Thr Lys Gly  Asn Glu Lys 
    1160                 1165                 1170             


Phe Phe  Lys Asn Phe Val Phe  Phe Phe Asn Leu Ile  Cys Gln Ile 
    1175                 1180                 1185             


Arg Asn  Thr Asn Ala Ser Glu  Leu Ala Lys Lys Asp  Gly Lys Asp 
    1190                 1195                 1200             


Asp Phe  Ile Leu Ser Pro Val  Glu Pro Phe Phe Asp  Ser Arg Asn 
    1205                 1210                 1215             


Ser Glu  Lys Phe Gly Glu Asp  Leu Pro Lys Asn Gly  Asp Asp Asn 
    1220                 1225                 1230             


Gly Ala  Phe Asn Ile Ala Arg  Lys Gly Leu Val Ile  Met Asp Lys 
    1235                 1240                 1245             


Ile Thr  Lys Phe Ala Asp Glu  Asn Gly Gly Cys Glu  Lys Met Lys 
    1250                 1255                 1260             


Trp Gly  Asp Leu Tyr Val Ser  Asn Val Glu Trp Asp  Asn Phe Val 
    1265                 1270                 1275             


Ala Asn  Lys 
    1280     


<210> 7
<211> 3846
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: 
      Synthetic polynucleotide

<400> 7
atgaaaaaaa gcatttttga tcagtttgtg aaccagtatg cgctgagcaa aaccctgcgc       60

ttcgagctga aaccggtggg tgaaaccggc cgtatgctgg aggaagcgaa ggttttcgcg      120

aaggatgaaa ccattaagaa aaagtacgaa gcgaccaagc cgttctttaa caaactgcac      180

cgtgaattcg tggaggaagc gctgaacgag gttgaactgg cgggcctgcc ggagtacttc      240

gaaatcttca agtactggaa gcgttacaaa aagaaattcg agaaggacct gcagaagaaa      300

gagaaggaac tgcgtaaaag cgtggttggt ttctttaacg cgcaagcgaa ggagtgggcg      360

aagaaatatg aaaccctggg cgtgaagaaa aaggatgttg gtctgctgtt cgaggaaaac      420

gtgtttgcga ttctgaaaga acgttacggt aacgaggaag gcagccagat tgtggacgag      480

agcaccggca aggatgttag catcttcgac agctggaagg gttttaccgg ctatttcatc      540

aaatttcagg aaacccgtaa gaacttctac aaagatgatg gtaccgcgac cgcgctggcg      600

acccgtatca ttgatcaaaa cctgaaacgt ttctgcgaca acctgctgat ctttgagagc      660

attcgtgata agatcgactt cagcgaggtt gaacagacca tgggcaacag catcgataag      720

gtgttcagcg ttatctttta tagcagctgc ctgctgcaag aaggtatcga cttttacaac      780

tgcgtgctgg gtggtgaaac cctgccgaac ggtgaaaagc gtcagggcat taacgaactg      840

atcaacctgt accgtcaaaa gaccagcgag aaagttccgt tcctgaagct gctggacaaa      900

cagattctga gcgagaagga aaaatttatg gatgagatcg aaaacgacga ggcgctgctg      960

gataccctga agattttccg taaaagcgcg gaggaaaaga ccaccctgct gaaaaacatc     1020

ttcggcgatt ttgtgatgaa ccagggtaaa tatgacctgg cgcaaatcta cattagccgt     1080

gaaagcctga acaccattag ccgtaagtgg accagcgaaa ccgatatctt cgaagacagc     1140

ctgtacgagg tgctgaaaaa gagcaaaatc gtgagcgcga gcgttaaaaa gaaagacggt     1200

ggctacgcgt tcccggagtt tatcgcgctg atttatgtta aaagcgcgct ggaacagatt     1260

ccgaccgaga agttctggaa agaacgttac tataagaaca tcggcgatgt gctgaacaag     1320

ggtttcctga acggtaaaga aggcgtttgg ctgcaatttc tgctgatctt tgacttcgaa     1380

tttaacagcc tgttcgagcg tgaaatcatt gatgagaacg gcgacaagaa agtggcgggt     1440

tataacctgt tcgcgaaggg ttttgacgat ctgctgaaca acttcaaata cgaccagaag     1500

gcgaaagtgg ttattaagga ttttgcggac gaagttctgc acatttatca aatgggcaaa     1560

tacttcgcga tcgagaagaa acgtagctgg ctggcggact atgatattga cagcttctac     1620

accgatccgg agaagggtta cctgaaattt tatgaaaacg cgtacgagga aatcattcag     1680

gtttataaca agctgcgtaa ctacctgacc aagaaaccgt atagcgagga caagtggaaa     1740

ctgaacttcg aaaacccgac cctggcggat ggttgggaca agaacaaaga ggcggataac     1800

agcaccgtga ttctgaagaa agacggtcgt tactatctgg gcctgatggc gcgtggtcgt     1860

aacaagctgt tcgacgatcg taacctgccg aaaatcctgg agggtgttga aaacggcaag     1920

tacgaaaagg tggtttacaa gtacttcccg gatcaggcga agatgttccc gaaagtgtgc     1980

tttagcacca aaggcctgga attctttcaa ccgagcgagg aagttatcac catttacaag     2040

aacagcgagt tcaagaaagg ttataccttt aacgtgcgta gcatgcagcg tctgattgat     2100

ttctataaag actgcctggt tcgttacgaa ggttggcaat gctatgattt tcgtaacctg     2160

cgtaagaccg aggactaccg taaaaacatc gaggaattct ttagcgatgt ggcgatggac     2220

ggctacaaga ttagcttcca ggacgttagc gagagctata tcaaggagaa gaaccaaaac     2280

ggtgatctgt acctgtttga gatcaagaac aaagactgga acgaaggtgc gaacggcaag     2340

aaaaacctgc acaccattta tttcgagagc ctgtttagcg cggataacat cgcgatgaac     2400

ttcccggtga aactgaacgg ccaggcggag atcttttacc gtccgcgtac cgaaggtctg     2460

gagaaggaac gtatcattac caagaaaggc aacgttctgg aaaagggtga caaagcgttc     2520

cacaagcgtc gttacaccga gaacaaagtg ttctttcacg ttccgattac cctgaaccgt     2580

accaagaaaa acccgttcca atttaacgcg aagatcaacg acttcctggc gaaaaacagc     2640

gatatcaacg tgattggtgt tgaccgtggc gagaaacagc tggcgtattt tagcgtgatt     2700

agccaacgtg gcaagatcct ggaccgtggt agcctgaacg tgatcaacgg cgttaactac     2760

gcggagaagc tggaggaaaa agcgcgtggt cgtgaacagg cgcgtaagga ttggcagcaa     2820

atcgagggca ttaaagacct gaagaaaggt tatattagcc aggtggttcg taaactggcg     2880

gatctggcga tccaatacaa cgcgatcatt gtgttcgagg acctgaacat gcgttttaag     2940

caaattcgtg gtggcatcga gaaaagcgtt tatcagcaac tggaaaaggc gctgatcgat     3000

aaactgacct tcctggtgga gaaggaagaa aaggacgttg aaaaggcggg tcacctgctg     3060

aaagcgtacc agctggcggc gccgttcgaa acctttcaga agatgggtaa acaaaccggc     3120

attgtgtttt atacccaagc ggcgtacacc agccgtatcg atccggttac cggctggcgt     3180

ccgcacctgt acctgaaata tagcagcgcg gaaaaggcga aagcggacct gctgaagttc     3240

aagaaaatta agttcgtgga tggtcgtttc gagtttacct acgacatcaa gagcttccgt     3300

gagcagaagg aacacccgaa agcgaccgtg tggaccgttt gcagctgcgt tgagcgtttt     3360

cgttggaacc gttatctgaa cagcaacaaa ggtggctacg atcactatag cgacgtgacc     3420

aagttcctgg ttgagctgtt tcaggaatac ggcatcgact tcgaacgtgg tgatattgtg     3480

ggccaaatcg aggttctgga aaccaagggt aacgagaagt tctttaagaa cttcgtgttc     3540

tttttcaacc tgatctgcca gattcgtaac accaacgcga gcgaactggc gaagaaagac     3600

ggcaaggacg atttcattct gagcccggtt gagccgtttt tcgatagccg taacagcgag     3660

aagttcggcg aagacctgcc gaaaaacggt gacgataacg gcgcgtttaa catcgcgcgt     3720

aaaggtctgg ttattatgga taagatcacc aaattcgcgg acgagaacgg tggctgcgaa     3780

aagatgaaat ggggtgacct gtatgtgagc aatgtggagt gggataactt tgtggcgaat     3840

aaataa                                                                3846


<210> 8
<211> 9
<212> PRT
<213> Unknown

<220>
<223> Description of Unknown: 
      "LAGLIDADG" motif sequence

<400> 8
Leu Ala Gly Leu Ile Asp Ala Asp Gly 
1               5                   


<210> 9
<211> 18
<212> RNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: 
      Synthetic oligonucleotide

<400> 9
cccccccccc cccccccc                                                     18


<210> 10
<211> 19
<212> RNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: 
      Synthetic oligonucleotide

<400> 10
cccccccccc ccccccccu                                                    19


<210> 11
<211> 20
<212> RNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: 
      Synthetic oligonucleotide

<400> 11
cccccccccc ccccccccuu                                                   20


<210> 12
<211> 21
<212> RNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: 
      Synthetic oligonucleotide

<400> 12
cccccccccc ccccccccuu a                                                 21


<210> 13
<211> 22
<212> RNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: 
      Synthetic oligonucleotide

<400> 13
cccccccccc ccccccccuu au                                                22


<210> 14
<211> 23
<212> RNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: 
      Synthetic oligonucleotide

<400> 14
cccccccccc ccccccccuu auu                                               23


<210> 15
<211> 1159
<212> PRT
<213> Leptotrichia buccalis

<400> 15
Met Lys Val Thr Lys Val Gly Gly Ile Ser His Lys Lys Tyr Thr Ser 
1               5                   10                  15      


Glu Gly Arg Leu Val Lys Ser Glu Ser Glu Glu Asn Arg Thr Asp Glu 
            20                  25                  30          


Arg Leu Ser Ala Leu Leu Asn Met Arg Leu Asp Met Tyr Ile Lys Asn 
        35                  40                  45              


Pro Ser Ser Thr Glu Thr Lys Glu Asn Gln Lys Arg Ile Gly Lys Leu 
    50                  55                  60                  


Lys Lys Phe Phe Ser Asn Lys Met Val Tyr Leu Lys Asp Asn Thr Leu 
65                  70                  75                  80  


Ser Leu Lys Asn Gly Lys Lys Glu Asn Ile Asp Arg Glu Tyr Ser Glu 
                85                  90                  95      


Thr Asp Ile Leu Glu Ser Asp Val Arg Asp Lys Lys Asn Phe Ala Val 
            100                 105                 110         


Leu Lys Lys Ile Tyr Leu Asn Glu Asn Val Asn Ser Glu Glu Leu Glu 
        115                 120                 125             


Val Phe Arg Asn Asp Ile Lys Lys Lys Leu Asn Lys Ile Asn Ser Leu 
    130                 135                 140                 


Lys Tyr Ser Phe Glu Lys Asn Lys Ala Asn Tyr Gln Lys Ile Asn Glu 
145                 150                 155                 160 


Asn Asn Ile Glu Lys Val Glu Gly Lys Ser Lys Arg Asn Ile Ile Tyr 
                165                 170                 175     


Asp Tyr Tyr Arg Glu Ser Ala Lys Arg Asp Ala Tyr Val Ser Asn Val 
            180                 185                 190         


Lys Glu Ala Phe Asp Lys Leu Tyr Lys Glu Glu Asp Ile Ala Lys Leu 
        195                 200                 205             


Val Leu Glu Ile Glu Asn Leu Thr Lys Leu Glu Lys Tyr Lys Ile Arg 
    210                 215                 220                 


Glu Phe Tyr His Glu Ile Ile Gly Arg Lys Asn Asp Lys Glu Asn Phe 
225                 230                 235                 240 


Ala Lys Ile Ile Tyr Glu Glu Ile Gln Asn Val Asn Asn Met Lys Glu 
                245                 250                 255     


Leu Ile Glu Lys Val Pro Asp Met Ser Glu Leu Lys Lys Ser Gln Val 
            260                 265                 270         


Phe Tyr Lys Tyr Tyr Leu Asp Lys Glu Glu Leu Asn Asp Lys Asn Ile 
        275                 280                 285             


Lys Tyr Ala Phe Cys His Phe Val Glu Ile Glu Met Ser Gln Leu Leu 
    290                 295                 300                 


Lys Asn Tyr Val Tyr Lys Arg Leu Ser Asn Ile Ser Asn Asp Lys Ile 
305                 310                 315                 320 


Lys Arg Ile Phe Glu Tyr Gln Asn Leu Lys Lys Leu Ile Glu Asn Lys 
                325                 330                 335     


Leu Leu Asn Lys Leu Asp Thr Tyr Val Arg Asn Cys Gly Lys Tyr Asn 
            340                 345                 350         


Tyr Tyr Leu Gln Asp Gly Glu Ile Ala Thr Ser Asp Phe Ile Ala Arg 
        355                 360                 365             


Asn Arg Gln Asn Glu Ala Phe Leu Arg Asn Ile Ile Gly Val Ser Ser 
    370                 375                 380                 


Val Ala Tyr Phe Ser Leu Arg Asn Ile Leu Glu Thr Glu Asn Glu Asn 
385                 390                 395                 400 


Asp Ile Thr Gly Arg Met Arg Gly Lys Thr Val Lys Asn Asn Lys Gly 
                405                 410                 415     


Glu Glu Lys Tyr Val Ser Gly Glu Val Asp Lys Ile Tyr Asn Glu Asn 
            420                 425                 430         


Lys Lys Asn Glu Val Lys Glu Asn Leu Lys Met Phe Tyr Ser Tyr Asp 
        435                 440                 445             


Phe Asn Met Asp Asn Lys Asn Glu Ile Glu Asp Phe Phe Ala Asn Ile 
    450                 455                 460                 


Asp Glu Ala Ile Ser Ser Ile Arg His Gly Ile Val His Phe Asn Leu 
465                 470                 475                 480 


Glu Leu Glu Gly Lys Asp Ile Phe Ala Phe Lys Asn Ile Ala Pro Ser 
                485                 490                 495     


Glu Ile Ser Lys Lys Met Phe Gln Asn Glu Ile Asn Glu Lys Lys Leu 
            500                 505                 510         


Lys Leu Lys Ile Phe Arg Gln Leu Asn Ser Ala Asn Val Phe Arg Tyr 
        515                 520                 525             


Leu Glu Lys Tyr Lys Ile Leu Asn Tyr Leu Lys Arg Thr Arg Phe Glu 
    530                 535                 540                 


Phe Val Asn Lys Asn Ile Pro Phe Val Pro Ser Phe Thr Lys Leu Tyr 
545                 550                 555                 560 


Ser Arg Ile Asp Asp Leu Lys Asn Ser Leu Gly Ile Tyr Trp Lys Thr 
                565                 570                 575     


Pro Lys Thr Asn Asp Asp Asn Lys Thr Lys Glu Ile Ile Asp Ala Gln 
            580                 585                 590         


Ile Tyr Leu Leu Lys Asn Ile Tyr Tyr Gly Glu Phe Leu Asn Tyr Phe 
        595                 600                 605             


Met Ser Asn Asn Gly Asn Phe Phe Glu Ile Ser Lys Glu Ile Ile Glu 
    610                 615                 620                 


Leu Asn Lys Asn Asp Lys Arg Asn Leu Lys Thr Gly Phe Tyr Lys Leu 
625                 630                 635                 640 


Gln Lys Phe Glu Asp Ile Gln Glu Lys Ile Pro Lys Glu Tyr Leu Ala 
                645                 650                 655     


Asn Ile Gln Ser Leu Tyr Met Ile Asn Ala Gly Asn Gln Asp Glu Glu 
            660                 665                 670         


Glu Lys Asp Thr Tyr Ile Asp Phe Ile Gln Lys Ile Phe Leu Lys Gly 
        675                 680                 685             


Phe Met Thr Tyr Leu Ala Asn Asn Gly Arg Leu Ser Leu Ile Tyr Ile 
    690                 695                 700                 


Gly Ser Asp Glu Glu Thr Asn Thr Ser Leu Ala Glu Lys Lys Gln Glu 
705                 710                 715                 720 


Phe Asp Lys Phe Leu Lys Lys Tyr Glu Gln Asn Asn Asn Ile Lys Ile 
                725                 730                 735     


Pro Tyr Glu Ile Asn Glu Phe Leu Arg Glu Ile Lys Leu Gly Asn Ile 
            740                 745                 750         


Leu Lys Tyr Thr Glu Arg Leu Asn Met Phe Tyr Leu Ile Leu Lys Leu 
        755                 760                 765             


Leu Asn His Lys Glu Leu Thr Asn Leu Lys Gly Ser Leu Glu Lys Tyr 
    770                 775                 780                 


Gln Ser Ala Asn Lys Glu Glu Ala Phe Ser Asp Gln Leu Glu Leu Ile 
785                 790                 795                 800 


Asn Leu Leu Asn Leu Asp Asn Asn Arg Val Thr Glu Asp Phe Glu Leu 
                805                 810                 815     


Glu Ala Asp Glu Ile Gly Lys Phe Leu Asp Phe Asn Gly Asn Lys Val 
            820                 825                 830         


Lys Asp Asn Lys Glu Leu Lys Lys Phe Asp Thr Asn Lys Ile Tyr Phe 
        835                 840                 845             


Asp Gly Glu Asn Ile Ile Lys His Arg Ala Phe Tyr Asn Ile Lys Lys 
    850                 855                 860                 


Tyr Gly Met Leu Asn Leu Leu Glu Lys Ile Ala Asp Lys Ala Gly Tyr 
865                 870                 875                 880 


Lys Ile Ser Ile Glu Glu Leu Lys Lys Tyr Ser Asn Lys Lys Asn Glu 
                885                 890                 895     


Ile Glu Lys Asn His Lys Met Gln Glu Asn Leu His Arg Lys Tyr Ala 
            900                 905                 910         


Arg Pro Arg Lys Asp Glu Lys Phe Thr Asp Glu Asp Tyr Glu Ser Tyr 
        915                 920                 925             


Lys Gln Ala Ile Glu Asn Ile Glu Glu Tyr Thr His Leu Lys Asn Lys 
    930                 935                 940                 


Val Glu Phe Asn Glu Leu Asn Leu Leu Gln Gly Leu Leu Leu Arg Ile 
945                 950                 955                 960 


Leu His Arg Leu Val Gly Tyr Thr Ser Ile Trp Glu Arg Asp Leu Arg 
                965                 970                 975     


Phe Arg Leu Lys Gly Glu Phe Pro Glu Asn Gln Tyr Ile Glu Glu Ile 
            980                 985                 990         


Phe Asn Phe Glu Asn Lys Lys Asn  Val Lys Tyr Lys Gly  Gly Gln Ile 
        995                 1000                 1005             


Val Glu  Lys Tyr Ile Lys Phe  Tyr Lys Glu Leu His  Gln Asn Asp 
    1010                 1015                 1020             


Glu Val  Lys Ile Asn Lys Tyr  Ser Ser Ala Asn Ile  Lys Val Leu 
    1025                 1030                 1035             


Lys Gln  Glu Lys Lys Asp Leu  Tyr Ile Arg Asn Tyr  Ile Ala His 
    1040                 1045                 1050             


Phe Asn  Tyr Ile Pro His Ala  Glu Ile Ser Leu Leu  Glu Val Leu 
    1055                 1060                 1065             


Glu Asn  Leu Arg Lys Leu Leu  Ser Tyr Asp Arg Lys  Leu Lys Asn 
    1070                 1075                 1080             


Ala Val  Met Lys Ser Val Val  Asp Ile Leu Lys Glu  Tyr Gly Phe 
    1085                 1090                 1095             


Val Ala  Thr Phe Lys Ile Gly  Ala Asp Lys Lys Ile  Gly Ile Gln 
    1100                 1105                 1110             


Thr Leu  Glu Ser Glu Lys Ile  Val His Leu Lys Asn  Leu Lys Lys 
    1115                 1120                 1125             


Lys Lys  Leu Met Thr Asp Arg  Asn Ser Glu Glu Leu  Cys Lys Leu 
    1130                 1135                 1140             


Val Lys  Ile Met Phe Glu Tyr  Lys Met Glu Glu Lys  Lys Ser Glu 
    1145                 1150                 1155             


Asn 
    


<210> 16
<211> 1152
<212> PRT
<213> Leptotrichia wadei

<400> 16
Met Lys Val Thr Lys Val Asp Gly Ile Ser His Lys Lys Tyr Ile Glu 
1               5                   10                  15      


Glu Gly Lys Leu Val Lys Ser Thr Ser Glu Glu Asn Arg Thr Ser Glu 
            20                  25                  30          


Arg Leu Ser Glu Leu Leu Ser Ile Arg Leu Asp Ile Tyr Ile Lys Asn 
        35                  40                  45              


Pro Asp Asn Ala Ser Glu Glu Glu Asn Arg Ile Arg Arg Glu Asn Leu 
    50                  55                  60                  


Lys Lys Phe Phe Ser Asn Lys Val Leu His Leu Lys Asp Ser Val Leu 
65                  70                  75                  80  


Tyr Leu Lys Asn Arg Lys Glu Lys Asn Ala Val Gln Asp Lys Asn Tyr 
                85                  90                  95      


Ser Glu Glu Asp Ile Ser Glu Tyr Asp Leu Lys Asn Lys Asn Ser Phe 
            100                 105                 110         


Ser Val Leu Lys Lys Ile Leu Leu Asn Glu Asp Val Asn Ser Glu Glu 
        115                 120                 125             


Leu Glu Ile Phe Arg Lys Asp Val Glu Ala Lys Leu Asn Lys Ile Asn 
    130                 135                 140                 


Ser Leu Lys Tyr Ser Phe Glu Glu Asn Lys Ala Asn Tyr Gln Lys Ile 
145                 150                 155                 160 


Asn Glu Asn Asn Val Glu Lys Val Gly Gly Lys Ser Lys Arg Asn Ile 
                165                 170                 175     


Ile Tyr Asp Tyr Tyr Arg Glu Ser Ala Lys Arg Asn Asp Tyr Ile Asn 
            180                 185                 190         


Asn Val Gln Glu Ala Phe Asp Lys Leu Tyr Lys Lys Glu Asp Ile Glu 
        195                 200                 205             


Lys Leu Phe Phe Leu Ile Glu Asn Ser Lys Lys His Glu Lys Tyr Lys 
    210                 215                 220                 


Ile Arg Glu Tyr Tyr His Lys Ile Ile Gly Arg Lys Asn Asp Lys Glu 
225                 230                 235                 240 


Asn Phe Ala Lys Ile Ile Tyr Glu Glu Ile Gln Asn Val Asn Asn Ile 
                245                 250                 255     


Lys Glu Leu Ile Glu Lys Ile Pro Asp Met Ser Glu Leu Lys Lys Ser 
            260                 265                 270         


Gln Val Phe Tyr Lys Tyr Tyr Leu Asp Lys Glu Glu Leu Asn Asp Lys 
        275                 280                 285             


Asn Ile Lys Tyr Ala Phe Cys His Phe Val Glu Ile Glu Met Ser Gln 
    290                 295                 300                 


Leu Leu Lys Asn Tyr Val Tyr Lys Arg Leu Ser Asn Ile Ser Asn Asp 
305                 310                 315                 320 


Lys Ile Lys Arg Ile Phe Glu Tyr Gln Asn Leu Lys Lys Leu Ile Glu 
                325                 330                 335     


Asn Lys Leu Leu Asn Lys Leu Asp Thr Tyr Val Arg Asn Cys Gly Lys 
            340                 345                 350         


Tyr Asn Tyr Tyr Leu Gln Val Gly Glu Ile Ala Thr Ser Asp Phe Ile 
        355                 360                 365             


Ala Arg Asn Arg Gln Asn Glu Ala Phe Leu Arg Asn Ile Ile Gly Val 
    370                 375                 380                 


Ser Ser Val Ala Tyr Phe Ser Leu Arg Asn Ile Leu Glu Thr Glu Asn 
385                 390                 395                 400 


Glu Asn Asp Ile Thr Gly Arg Met Arg Gly Lys Thr Val Lys Asn Asn 
                405                 410                 415     


Lys Gly Glu Glu Lys Tyr Val Ser Gly Glu Val Asp Lys Ile Tyr Asn 
            420                 425                 430         


Glu Asn Lys Gln Asn Glu Val Lys Glu Asn Leu Lys Met Phe Tyr Ser 
        435                 440                 445             


Tyr Asp Phe Asn Met Asp Asn Lys Asn Glu Ile Glu Asp Phe Phe Ala 
    450                 455                 460                 


Asn Ile Asp Glu Ala Ile Ser Ser Ile Arg His Gly Ile Val His Phe 
465                 470                 475                 480 


Asn Leu Glu Leu Glu Gly Lys Asp Ile Phe Ala Phe Lys Asn Ile Ala 
                485                 490                 495     


Pro Ser Glu Ile Ser Lys Lys Met Phe Gln Asn Glu Ile Asn Glu Lys 
            500                 505                 510         


Lys Leu Lys Leu Lys Ile Phe Lys Gln Leu Asn Ser Ala Asn Val Phe 
        515                 520                 525             


Asn Tyr Tyr Glu Lys Asp Val Ile Ile Lys Tyr Leu Lys Asn Thr Lys 
    530                 535                 540                 


Phe Asn Phe Val Asn Lys Asn Ile Pro Phe Val Pro Ser Phe Thr Lys 
545                 550                 555                 560 


Leu Tyr Asn Lys Ile Glu Asp Leu Arg Asn Thr Leu Lys Phe Phe Trp 
                565                 570                 575     


Ser Val Pro Lys Asp Lys Glu Glu Lys Asp Ala Gln Ile Tyr Leu Leu 
            580                 585                 590         


Lys Asn Ile Tyr Tyr Gly Glu Phe Leu Asn Lys Phe Val Lys Asn Ser 
        595                 600                 605             


Lys Val Phe Phe Lys Ile Thr Asn Glu Val Ile Lys Ile Asn Lys Gln 
    610                 615                 620                 


Arg Asn Gln Lys Thr Gly His Tyr Lys Tyr Gln Lys Phe Glu Asn Ile 
625                 630                 635                 640 


Glu Lys Thr Val Pro Val Glu Tyr Leu Ala Ile Ile Gln Ser Arg Glu 
                645                 650                 655     


Met Ile Asn Asn Gln Asp Lys Glu Glu Lys Asn Thr Tyr Ile Asp Phe 
            660                 665                 670         


Ile Gln Gln Ile Phe Leu Lys Gly Phe Ile Asp Tyr Leu Asn Lys Asn 
        675                 680                 685             


Asn Leu Lys Tyr Ile Glu Ser Asn Asn Asn Asn Asp Asn Asn Asp Ile 
    690                 695                 700                 


Phe Ser Lys Ile Lys Ile Lys Lys Asp Asn Lys Glu Lys Tyr Asp Lys 
705                 710                 715                 720 


Ile Leu Lys Asn Tyr Glu Lys His Asn Arg Asn Lys Glu Ile Pro His 
                725                 730                 735     


Glu Ile Asn Glu Phe Val Arg Glu Ile Lys Leu Gly Lys Ile Leu Lys 
            740                 745                 750         


Tyr Thr Glu Asn Leu Asn Met Phe Tyr Leu Ile Leu Lys Leu Leu Asn 
        755                 760                 765             


His Lys Glu Leu Thr Asn Leu Lys Gly Ser Leu Glu Lys Tyr Gln Ser 
    770                 775                 780                 


Ala Asn Lys Glu Glu Thr Phe Ser Asp Glu Leu Glu Leu Ile Asn Leu 
785                 790                 795                 800 


Leu Asn Leu Asp Asn Asn Arg Val Thr Glu Asp Phe Glu Leu Glu Ala 
                805                 810                 815     


Asn Glu Ile Gly Lys Phe Leu Asp Phe Asn Glu Asn Lys Ile Lys Asp 
            820                 825                 830         


Arg Lys Glu Leu Lys Lys Phe Asp Thr Asn Lys Ile Tyr Phe Asp Gly 
        835                 840                 845             


Glu Asn Ile Ile Lys His Arg Ala Phe Tyr Asn Ile Lys Lys Tyr Gly 
    850                 855                 860                 


Met Leu Asn Leu Leu Glu Lys Ile Ala Asp Lys Ala Lys Tyr Lys Ile 
865                 870                 875                 880 


Ser Leu Lys Glu Leu Lys Glu Tyr Ser Asn Lys Lys Asn Glu Ile Glu 
                885                 890                 895     


Lys Asn Tyr Thr Met Gln Gln Asn Leu His Arg Lys Tyr Ala Arg Pro 
            900                 905                 910         


Lys Lys Asp Glu Lys Phe Asn Asp Glu Asp Tyr Lys Glu Tyr Glu Lys 
        915                 920                 925             


Ala Ile Gly Asn Ile Gln Lys Tyr Thr His Leu Lys Asn Lys Val Glu 
    930                 935                 940                 


Phe Asn Glu Leu Asn Leu Leu Gln Gly Leu Leu Leu Lys Ile Leu His 
945                 950                 955                 960 


Arg Leu Val Gly Tyr Thr Ser Ile Trp Glu Arg Asp Leu Arg Phe Arg 
                965                 970                 975     


Leu Lys Gly Glu Phe Pro Glu Asn His Tyr Ile Glu Glu Ile Phe Asn 
            980                 985                 990         


Phe Asp Asn Ser Lys Asn Val Lys  Tyr Lys Ser Gly Gln  Ile Val Glu 
        995                 1000                 1005             


Lys Tyr  Ile Asn Phe Tyr Lys  Glu Leu Tyr Lys Asp  Asn Val Glu 
    1010                 1015                 1020             


Lys Arg  Ser Ile Tyr Ser Asp  Lys Lys Val Lys Lys  Leu Lys Gln 
    1025                 1030                 1035             


Glu Lys  Lys Asp Leu Tyr Ile  Arg Asn Tyr Ile Ala  His Phe Asn 
    1040                 1045                 1050             


Tyr Ile  Pro His Ala Glu Ile  Ser Leu Leu Glu Val  Leu Glu Asn 
    1055                 1060                 1065             


Leu Arg  Lys Leu Leu Ser Tyr  Asp Arg Lys Leu Lys  Asn Ala Ile 
    1070                 1075                 1080             


Met Lys  Ser Ile Val Asp Ile  Leu Lys Glu Tyr Gly  Phe Val Ala 
    1085                 1090                 1095             


Thr Phe  Lys Ile Gly Ala Asp  Lys Lys Ile Glu Ile  Gln Thr Leu 
    1100                 1105                 1110             


Glu Ser  Glu Lys Ile Val His  Leu Lys Asn Leu Lys  Lys Lys Lys 
    1115                 1120                 1125             


Leu Met  Thr Asp Arg Asn Ser  Glu Glu Leu Cys Glu  Leu Val Lys 
    1130                 1135                 1140             


Val Met  Phe Glu Tyr Lys Ala  Leu Glu 
    1145                 1150         


<210> 17
<211> 425
<212> PRT
<213> Unknown

<220>
<223> Description of Unknown: Unclassified 
      Synechocystis sequence

<400> 17
Met Arg Thr Ala Ile Thr Lys Ile Ile Ser Phe Leu Gly Phe Asn Ser 
1               5                   10                  15      


Tyr Glu Val Thr Thr Tyr Lys His Pro Thr Gln Ser Ile His Leu Thr 
            20                  25                  30          


Thr Lys Tyr Tyr Gln Glu Ala Leu Ala Glu Phe Tyr Gln Pro Gln Lys 
        35                  40                  45              


Ile Tyr Ile Phe Leu Thr Pro Thr Val Glu Thr Lys Cys Pro Gly Arg 
    50                  55                  60                  


Gly Asp Gln Lys Glu Asp Arg Ser Asn Trp His Gln Leu Glu Glu Ile 
65                  70                  75                  80  


Leu Ala Gln Lys Phe Pro Asp Ile Glu Ile Val Pro Val Lys Asn Ile 
                85                  90                  95      


Pro Glu Arg Asn Ser Pro Glu Asp Ile Trp Thr Ile Phe Asn Lys Val 
            100                 105                 110         


Asn Glu Cys Leu Glu Asp Gly Asp Arg Val Ile Phe Asp Ile Thr His 
        115                 120                 125             


Ser Phe Arg Ser Val Pro Ile Val Ala Leu Leu Ala Val Ser Tyr Phe 
    130                 135                 140                 


Arg Val Val Arg Asn Ile Thr Ile Glu Gly Leu Leu Tyr Gly Ala Phe 
145                 150                 155                 160 


Glu Ala Lys Glu Asn Gly Ile Thr Pro Thr Phe Asp Leu Leu Pro Val 
                165                 170                 175     


Val Arg Leu Phe Asp Trp Leu Thr Ala Thr Asp Gln Phe Leu Lys Thr 
            180                 185                 190         


Gly Asn Gly Glu Asp Leu Ala Lys Leu Leu Gln Glu Ala Glu Gly His 
        195                 200                 205             


Thr Gln Ala Leu Gly Asp Arg Ile Leu Glu Ile Ser Gln Gly Leu Gln 
    210                 215                 220                 


Leu Leu Arg Pro Met Asp Val Met Thr Ala Ala Ala Ala Leu Pro Glu 
225                 230                 235                 240 


Ser Ile Glu Gln Gly Lys Pro Asp Leu Ala Arg Val Val Pro Pro Phe 
                245                 250                 255     


Glu Leu Leu Leu Asn Arg Val Val Ser Glu Tyr Gly Gln Phe Ala Leu 
            260                 265                 270         


Ala Glu Pro Lys Asn Tyr Gln Val Asn Gly Lys Ala Ala Leu Gln Lys 
        275                 280                 285             


Gln Phe Phe Glu Ile Glu Trp Tyr Ala Lys Lys Gly Leu Tyr Val Gln 
    290                 295                 300                 


Ala Ile Ser Leu Gly Arg Glu Trp Leu Pro Ser Leu Leu Cys Tyr Asn 
305                 310                 315                 320 


Phe Glu Leu Asp Pro Met Asp Lys Gln Ala Arg Glu Glu Met Glu Ile 
                325                 330                 335     


Leu Cys Cys Gly Gly Lys Val Gly Glu Arg Glu Ser Ile Tyr Arg Ser 
            340                 345                 350         


Gln Tyr Lys Glu Ile Glu Glu Ser Lys Arg Lys Met Ile Asn Gln Leu 
        355                 360                 365             


Trp Asn Asn Pro Pro Cys Lys Leu Ala Asn Leu Arg Asn Asp Val Leu 
    370                 375                 380                 


His Ser Gly Phe Arg Lys Asp Pro Lys Ser Val Glu Asp Ile Lys Gln 
385                 390                 395                 400 


Thr Leu Gln Lys Ile Val Glu Asp Leu Lys Lys Ile Ala Gln Val Trp 
                405                 410                 415     


Gly Val Phe Asp Glu Glu Tyr Lys Ser 
            420                 425 


<210> 18
<211> 480
<212> PRT
<213> Pyrococcus furiosus

<400> 18
Met Gly Met Arg Val Leu Val Thr Thr Trp Gly Asn Pro Phe Gln Trp 
1               5                   10                  15      


Glu Pro Ile Thr Tyr Glu Tyr Arg Gly Ile Lys Val Lys Ser Arg Asn 
            20                  25                  30          


Thr Leu Pro Ile Leu Val Lys Thr Leu Glu Pro Glu Arg Ile Leu Ile 
        35                  40                  45              


Leu Val Ala Asp Thr Met Ala Asn Tyr Tyr Asp Ser Gly Lys Asn Lys 
    50                  55                  60                  


Pro Glu Ile Glu Glu Lys Ser Phe Ser Ser Tyr Ser Glu Val Val Glu 
65                  70                  75                  80  


Asp Thr Lys Glu Arg Ile Leu Trp His Ile Lys Glu Glu Val Ile Glu 
                85                  90                  95      


Glu Leu Arg Glu Glu Asp Pro Glu Leu Ala Lys Lys Ile Glu Asn Met 
            100                 105                 110         


Leu Lys Asp Glu Arg Ile Thr Ile Glu Val Leu Pro Gly Val Gly Val 
        115                 120                 125             


Phe Gly Asn Ile Thr Val Glu Gly Glu Met Leu Asp Phe Tyr Tyr Tyr 
    130                 135                 140                 


Ala Thr Tyr Lys Leu Ala Glu Trp Leu Pro Val Gln Asn Asn Leu Glu 
145                 150                 155                 160 


Val Tyr Leu Asp Leu Thr His Gly Ile Asn Phe Met Pro Thr Phe Thr 
                165                 170                 175     


Tyr Arg Ala Leu Arg Asn Leu Leu Gly Leu Leu Ala Tyr Leu Tyr Asn 
            180                 185                 190         


Val Lys Phe Glu Ile Val Asn Ser Glu Pro Tyr Pro Leu Gly Val Ser 
        195                 200                 205             


Gln Glu Ile Arg Glu Asp Thr Ile Leu His Ile Arg Glu Ile Gly Glu 
    210                 215                 220                 


Gly Val Val Arg Pro Arg Pro Gln Tyr Ser Pro Val Glu Gly Lys Leu 
225                 230                 235                 240 


Tyr Trp Asn Ala Phe Ile Ser Ser Val Ala Asn Gly Phe Pro Leu Val 
                245                 250                 255     


Phe Ala Ser Phe Tyr Pro Asn Ile Arg Asp Val Glu Asp Tyr Leu Asn 
            260                 265                 270         


Lys Lys Leu Glu Glu Phe Leu Val Gly Ile Glu Val Gly Glu Arg Glu 
        275                 280                 285             


Asp Gly Lys Pro Tyr Val Lys Arg Glu Lys Ala Leu Asp Arg Ser Phe 
    290                 295                 300                 


Lys Asn Ala Ser Lys Leu Tyr Tyr Ala Leu Arg Val Phe Asn Thr Lys 
305                 310                 315                 320 


Phe Gln Asn Tyr Pro Lys Lys Glu Val Pro Ile Glu Glu Ile Met Glu 
                325                 330                 335     


Ile Ser Lys Ile Phe Glu Ser Leu Pro Arg Ile Gly Ile Ile Leu Glu 
            340                 345                 350         


Arg Gln Val Glu Trp Leu Arg Asn Leu Val Tyr Gly Arg Leu Trp Tyr 
        355                 360                 365             


Glu Asn Gly Glu Gln Lys Ile Lys Lys Gly Leu Leu Glu Ile Ile Lys 
    370                 375                 380                 


Asp Lys Lys Asp Lys Arg Lys Glu Ala Glu Ala Leu Lys Lys Gly Lys 
385                 390                 395                 400 


Thr Ile Ser Leu Ala Glu Ala Ala Lys Leu Thr Arg Ile Phe Ser Pro 
                405                 410                 415     


Ser Gly Glu Arg Ile Glu Thr Ile Glu Ser Pro Asn Val Val Arg Asn 
            420                 425                 430         


Phe Ile Ala His Ser Gly Phe Glu Tyr Asn Ile Val Tyr Val Lys Tyr 
        435                 440                 445             


Asp Arg Leu Ser Asp Arg Leu Tyr Phe Phe Tyr Lys Asp Lys Glu Lys 
    450                 455                 460                 


Ala Ala Asn Leu Ala Tyr Glu Ala Leu Leu Tyr Arg Gly Glu Lys Glu 
465                 470                 475                 480 


<210> 19
<211> 464
<212> PRT
<213> Thermus thermophilus

<400> 19
Met Glu Asp Leu Asp Ala Leu Trp Glu Arg Tyr Arg Glu Ala Val Arg 
1               5                   10                  15      


Ala Arg Gly Asn Pro Gln Ala Leu Tyr Gln Glu Met Val Trp Pro Ala 
            20                  25                  30          


Leu Leu Ala Leu Trp Arg Glu Lys Pro Arg Val Tyr Pro Phe Pro Gln 
        35                  40                  45              


Ala Phe Ala Val Ser Val His Thr Leu Gly Thr Ser Pro Glu Ala Thr 
    50                  55                  60                  


Ala Leu Ala Ile Leu Gly Ala Gly Ala Glu Arg Val Tyr Val Leu His 
65                  70                  75                  80  


Thr Pro Glu Ser Ala Arg Phe Leu Pro Arg Leu Arg Gln Asp Thr Gly 
                85                  90                  95      


Lys Asp Leu Tyr Pro Val Glu Ile Gly Lys Ser Asp Val Glu Ala Ile 
            100                 105                 110         


Tyr Arg Glu Val Lys Arg Leu Leu Glu Lys His Pro Glu Val Pro Val 
        115                 120                 125             


Ala Leu Asp Leu Thr Ser Gly Thr Lys Ala Met Ser Ala Gly Leu Ala 
    130                 135                 140                 


Ala Ala Gly Phe Phe Phe Gln Arg Phe Tyr Pro Lys Val Arg Val Val 
145                 150                 155                 160 


Tyr Val Asp Asn Glu Asp Tyr Asp Pro Glu Leu Arg Arg Pro Arg Ala 
                165                 170                 175     


Gly Thr Glu Lys Leu Arg Ile Leu Pro Asn Pro His Glu Ala Leu Ala 
            180                 185                 190         


Glu Val Asp Ala Leu Phe Ala Lys Glu Leu Tyr Gly Lys Gly Glu Phe 
        195                 200                 205             


Gly Gln Ala Ala Ala Tyr Phe Arg Gly Met Val Gly Arg Thr Gly Asn 
    210                 215                 220                 


Gln Ala Tyr Ala Leu Tyr Ala Leu Leu Ala Glu Met Tyr Arg Ala Trp 
225                 230                 235                 240 


Arg Ala Leu Asp Phe Gly Glu Ala Leu Lys Ala Gly Arg Lys Leu Leu 
                245                 250                 255     


Gly Gln Leu Ser Gln Asn Val Trp Leu Asn His Pro Leu Asn Ala Arg 
            260                 265                 270         


Arg Glu Ala Leu Glu Ala Gln Val Ala Leu Leu Glu Ala Val Asp Arg 
        275                 280                 285             


Phe Leu Lys Ala Arg Asp Phe Ala Leu Lys Glu Gly Val Tyr Gly Leu 
    290                 295                 300                 


Ala Arg Thr Leu Leu His Leu Ala Gln Glu Ala Lys Glu Glu Ala Ala 
305                 310                 315                 320 


Val Leu Ala Ala Leu Tyr Ala Tyr Arg Ala Leu Glu Leu Leu Leu Gln 
                325                 330                 335     


Glu Arg Leu Ala Leu Leu Gly Arg Arg Ala Glu Ala Pro Gly Leu Ser 
            340                 345                 350         


Pro Glu Glu Ala Glu Ala Leu Arg Lys Ala Leu Ala Glu Leu Leu Gly 
        355                 360                 365             


Val Leu Pro Glu Glu Val Arg Leu Pro Ala Lys Leu Gly Leu Leu Asp 
    370                 375                 380                 


Leu Leu Ala Phe Leu Arg Leu Lys Gly Asp Glu Ala Leu Gly Arg Leu 
385                 390                 395                 400 


Ser Leu Ala Glu Leu Arg Gly Leu Ala Gly Ala Leu Lys Gly Arg Asn 
                405                 410                 415     


Ser Ala Leu Leu Val His Gly Phe Asp Val Pro Ser Pro Lys Ala Val 
            420                 425                 430         


Glu Gly Ile Ala Arg Leu Ala Gln Gly Leu Leu Gln Asp Leu Glu Ala 
        435                 440                 445             


Arg Thr Ala Leu Gly Pro Leu Ser Pro Glu Pro Val Pro Leu Gly Phe 
    450                 455                 460                 


<210> 20
<211> 241
<212> PRT
<213> Escherichia coli

<400> 20
Met Ser Asp Trp Ser Leu Ser Gln Leu Phe Ala Ser Leu His Glu Asp 
1               5                   10                  15      


Ile Gln Leu Arg Leu Gly Thr Ala Arg Lys Ala Phe Gln His Pro Gly 
            20                  25                  30          


Ala Lys Gly Asp Ala Ser Glu Gly Val Trp Ile Glu Met Leu Asp Thr 
        35                  40                  45              


Tyr Leu Pro Lys Arg Tyr Gln Ala Ala Asn Ala Phe Val Val Asp Ser 
    50                  55                  60                  


Leu Gly Asn Phe Ser Asp Gln Ile Asp Val Val Val Phe Asp Arg Gln 
65                  70                  75                  80  


Tyr Ser Pro Phe Ile Phe Lys Phe Asn Glu Gln Ile Ile Val Pro Ala 
                85                  90                  95      


Glu Ser Val Tyr Ala Val Phe Glu Ala Lys Gln Ser Ala Ser Ala Asp 
            100                 105                 110         


Leu Val Ala Tyr Ala Gln Arg Lys Val Ala Ser Val Arg Arg Leu His 
        115                 120                 125             


Arg Thr Ser Leu Pro Ile Pro His Ala Gly Gly Thr Tyr Pro Ala Lys 
    130                 135                 140                 


Pro Leu Ile Pro Ile Leu Gly Gly Leu Leu Thr Phe Glu Ser Asp Trp 
145                 150                 155                 160 


Ser Pro Ala Leu Gly Met Ser Phe Asp Lys Ala Leu Asn Gly Asp Leu 
                165                 170                 175     


Ser Asp Gly Arg Leu Asp Met Gly Cys Val Ala Ser His Gly His Phe 
            180                 185                 190         


Tyr Phe Asn Asn Ile Asp Ser Lys Phe Asn Phe Glu His Gly Asn Lys 
        195                 200                 205             


Pro Ala Thr Ala Phe Leu Phe Arg Leu Ile Ala Gln Leu Gln Phe Ser 
    210                 215                 220                 


Gly Thr Val Pro Met Ile Asp Ile Asp Ala Tyr Gly Lys Trp Leu Ala 
225                 230                 235                 240 


Asn 
    


<210> 21
<211> 241
<212> PRT
<213> Pseudomona aeruginosa

<400> 21
Met Ser Gln Trp Ser Leu Ser Gln Leu Leu Ser Ser Leu His Glu Asp 
1               5                   10                  15      


Ile Gln Gln Arg Leu Ser Val Val Arg Lys Thr Phe Gly His Pro Gly 
            20                  25                  30          


Thr Lys Gly Asp Ala Ser Glu Asn Val Trp Ile Asp Met Leu Asp Thr 
        35                  40                  45              


Tyr Leu Pro Lys Arg Tyr Gln Ala Ala Lys Ala His Val Val Asp Ser 
    50                  55                  60                  


Leu Gly Asn Phe Ser Gln Gln Ile Asp Val Val Val Phe Asp Arg Gln 
65                  70                  75                  80  


Tyr Ser Pro Phe Ile Phe Thr Tyr Glu Asn Glu Thr Ile Ile Pro Ala 
                85                  90                  95      


Glu Ser Val Tyr Ala Val Phe Glu Ala Lys Gln Thr Ala Asp Ala Gly 
            100                 105                 110         


Leu Val Ala Tyr Ala Gln Glu Lys Val Ala Ser Val Arg Arg Leu His 
        115                 120                 125             


Arg Thr Ser Leu Pro Ile Pro His Ala Gly Gly Thr Tyr Pro Ala Lys 
    130                 135                 140                 


Pro Leu Ile Pro Ile Leu Gly Gly Leu Leu Thr Phe Glu Ser Glu Trp 
145                 150                 155                 160 


Ser Pro Ala Leu Gly Pro Ser Met Asp Lys Ala Leu Asn Ala Asn Leu 
                165                 170                 175     


Thr Glu Gly Arg Leu Asp Ile Gly Cys Val Ala Ala His Gly His Phe 
            180                 185                 190         


Phe Tyr Asp Gln Ala Ser Gly Ala Tyr Ser Tyr Thr Asn Glu Asn Lys 
        195                 200                 205             


Pro Ala Thr Ala Phe Leu Phe Lys Leu Ile Ala Gln Leu Gln Phe Ser 
    210                 215                 220                 


Gly Thr Val Pro Met Ile Asp Val Glu Ala Tyr Gly Gln Trp Leu Thr 
225                 230                 235                 240 


Lys 
    


<210> 22
<211> 12
<212> RNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: 
      Synthetic oligonucleotide

<400> 22
auguccccug aa                                                           12



