                         SEQUENCE LISTING

<110>  SOMALOGIC OPERATING CO., INC.
       GELINAS, Amy D. et al.
 
<120>  NUCLEIC ACID COMPOUNDS THAT BIND CORONAVIRUS PROTEINS

<130>  01137-0058-00PCT

<150>  US 63/174,747
<151>  2021-04-14

<160>  268   

<170>  PatentIn version 3.5

<210>  1
<211>  83
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Synthetic: Template 1


<220>
<221>  modified_base
<222>  (1)..(2)
<223>  Biotin

<220>
<221>  misc_feature
<222>  (34)..(63)
<223>  n is a, c, g, or t

<400>  1
aatttttttt ctctcttcct ccctttttcc ttcnnnnnnn nnnnnnnnnn nnnnnnnnnn       60

nnncaaggta ggtcggcgtc act                                               83


<210>  2
<211>  28
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Synthetic: Primer 1

<400>  2
atatatatag tgacgccgac ctaccttg                                          28


<210>  3
<211>  33
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Synthetic: Primer 2


<220>
<221>  modified_base
<222>  (1)..(2)
<223>  Biotin

<400>  3
aatttttttt ctctcttcct ccctttttcc ttc                                    33


<210>  4
<211>  31
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Synthetic: aptamer


<220>
<221>  misc_feature
<222>  (5)..(5)
<223>  n is Tyr-dU

<220>
<221>  misc_feature
<222>  (7)..(7)
<223>  n is Nap-dC

<220>
<221>  misc_feature
<222>  (8)..(8)
<223>  n is Tyr-dU

<220>
<221>  misc_feature
<222>  (10)..(10)
<223>  n is Tyr-dU

<220>
<221>  misc_feature
<222>  (12)..(12)
<223>  n is Nap-dC

<220>
<221>  misc_feature
<222>  (14)..(14)
<223>  n is Tyr-dU

<220>
<221>  misc_feature
<222>  (15)..(15)
<223>  n is Nap-dC

<220>
<221>  misc_feature
<222>  (16)..(16)
<223>  n is Nap-dC

<220>
<221>  misc_feature
<222>  (19)..(19)
<223>  n is Nap-dC

<220>
<221>  misc_feature
<222>  (20)..(20)
<223>  n is Nap-dC

<220>
<221>  misc_feature
<222>  (22)..(22)
<223>  n is Nap-dC

<220>
<221>  misc_feature
<222>  (23)..(23)
<223>  n is Tyr-dU

<220>
<221>  misc_feature
<222>  (24)..(24)
<223>  n is Nap-dC

<220>
<221>  misc_feature
<222>  (28)..(28)
<223>  n is Nap-dC

<400>  4
ggganannan gngnnngann gnnnggangg a                                      31


<210>  5
<211>  31
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Synthetic: aptamer


<220>
<221>  misc_feature
<223>  See specification as filed for detailed description of 
       substitutions and preferred embodiments

<220>
<221>  misc_feature
<222>  (2)..(2)
<223>  n is dA, dG or a C-5 modified pyrimidine nucleoside

<220>
<221>  misc_feature
<222>  (5)..(5)
<223>  n is a C-5 modified pyrimidine nucleoside

<220>
<221>  misc_feature
<222>  (7)..(7)
<223>  n is a C-5 modified pyrimidine nucleoside

<220>
<221>  misc_feature
<222>  (8)..(8)
<223>  n is a C-5 modified pyrimidine nucleoside

<220>
<221>  misc_feature
<222>  (10)..(10)
<223>  n is dA or a C-5 modified pyrimidine nucleoside

<220>
<221>  misc_feature
<222>  (12)..(12)
<223>  n is a C-5 modified pyrimidine nucleoside

<220>
<221>  misc_feature
<222>  (14)..(14)
<223>  n is a C-5 modified pyrimidine nucleoside

<220>
<221>  misc_feature
<222>  (15)..(15)
<223>  n is a C-5 modified pyrimidine nucleoside

<220>
<221>  misc_feature
<222>  (16)..(16)
<223>  n is dA or a C-5 modified pyrimidine nucleoside

<220>
<221>  misc_feature
<222>  (19)..(19)
<223>  n is a C-5 modified pyrimidine nucleoside

<220>
<221>  misc_feature
<222>  (20)..(20)
<223>  n is dA or a C-5 modified pyrimidine nucleoside

<220>
<221>  misc_feature
<222>  (22)..(22)
<223>  n is a C-5 modified pyrimidine nucleoside

<220>
<221>  misc_feature
<222>  (23)..(23)
<223>  n is a C-5 modified pyrimidine nucleoside

<220>
<221>  misc_feature
<222>  (24)..(24)
<223>  n is a C-5 modified pyrimidine nucleoside

<220>
<221>  misc_feature
<222>  (28)..(28)
<223>  n is a C-5 modified pyrimidine nucleoside

<220>
<221>  misc_feature
<222>  (29)..(29)
<223>  n is dA, dG or a C-5 modified pyrimidine nucleoside

<220>
<221>  misc_feature
<222>  (30)..(30)
<223>  n is dA, dG or a C-5 modified pyrimidine nucleoside

<220>
<221>  misc_feature
<222>  (31)..(31)
<223>  n is dA, dG or a C-5 modified pyrimidine nucleoside

<400>  5
gnranrnnan rnrnnnrann rnnnrrannn n                                      31


<210>  6
<211>  40
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Synthetic: 26874-29_4


<220>
<221>  misc_feature
<222>  (1)..(40)
<223>  Every n is a C-5 modified pyrimidine such as Tyr-dU or Nap-dC - 
       see specification as filed for detailed description of 
       substitutions and preferred embodiments

<400>  6
ccttgggana nnangngnnn ganngnnngg anggagaagg                             40


<210>  7
<211>  29
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Synthetic: 26874-29_20


<220>
<221>  misc_feature
<222>  (1)..(29)
<223>  Every n is a C-5 modified pyrimidine such as Tyr-dU or Nap-dC - 
       see specification as filed for detailed description of 
       substitutions and preferred embodiments

<400>  7
ggganannan gngnnngann gnnnggang                                         29


<210>  8
<211>  38
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Synthetic: 26874-29_6


<220>
<221>  misc_feature
<222>  (1)..(38)
<223>  Every n is a C-5 modified pyrimidine such as Tyr-dU or Nap-dC - 
       see specification as filed for detailed description of 
       substitutions and preferred embodiments

<400>  8
ttggganann angngnnnga nngnnnggan ggagaagg                               38


<210>  9
<211>  36
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Synthetic: 26874-29_7


<220>
<221>  misc_feature
<222>  (1)..(36)
<223>  Every n is a C-5 modified pyrimidine such as Tyr-dU or Nap-dC - 
       see specification as filed for detailed description of 
       substitutions and preferred embodiments

<400>  9
ggganannan gngnnngann gnnnggangg agaagg                                 36


<210>  10
<211>  38
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Synthetic: 26874-29_12


<220>
<221>  misc_feature
<222>  (1)..(38)
<223>  Every n is a C-5 modified pyrimidine such as Tyr-dU or Nap-dC - 
       see specification as filed for detailed description of 
       substitutions and preferred embodiments

<400>  10
ccttgggana nnangngnnn ganngnnngg anggagaa                               38


<210>  11
<211>  36
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Synthetic: 26874-29_13


<220>
<221>  misc_feature
<222>  (1)..(36)
<223>  Every n is a C-5 modified pyrimidine such as Tyr-dU or Nap-dC - 
       see specification as filed for detailed description of 
       substitutions and preferred embodiments

<400>  11
ccttgggana nnangngnnn ganngnnngg anggag                                 36


<210>  12
<211>  34
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Synthetic: 26874-29_14


<220>
<221>  misc_feature
<222>  (1)..(34)
<223>  Every n is a C-5 modified pyrimidine such as Tyr-dU or Nap-dC - 
       see specification as filed for detailed description of 
       substitutions and preferred embodiments

<400>  12
ccttgggana nnangngnnn ganngnnngg angg                                   34


<210>  13
<211>  32
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Synthetic: 26874-29_15


<220>
<221>  misc_feature
<222>  (1)..(32)
<223>  Every n is a C-5 modified pyrimidine such as Tyr-dU or Nap-dC - 
       see specification as filed for detailed description of 
       substitutions and preferred embodiments

<400>  13
ccttgggana nnangngnnn ganngnnngg an                                     32


<210>  14
<211>  30
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Synthetic: 26874-29_18


<220>
<221>  misc_feature
<222>  (1)..(30)
<223>  Every n is a C-5 modified pyrimidine such as Tyr-dU or Nap-dC - 
       see specification as filed for detailed description of 
       substitutions and preferred embodiments

<400>  14
ggganannan gngnnngann gnnnggangg                                        30


<210>  15
<211>  29
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Synthetic: 26874-29_19


<220>
<221>  misc_feature
<222>  (1)..(29)
<223>  Every n is a C-5 modified pyrimidine such as Tyr-dU or Nap-dC - 
       see specification as filed for detailed description of 
       substitutions and preferred embodiments

<400>  15
gganannang ngnnnganng nnnggangg                                         29


<210>  16
<211>  28
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Synthetic: 26874-29_21


<220>
<221>  misc_feature
<222>  (1)..(28)
<223>  Every n is a C-5 modified pyrimidine such as Tyr-dU or Nap-dC - 
       see specification as filed for detailed description of 
       substitutions and preferred embodiments

<400>  16
gganannang ngnnnganng nnnggang                                          28


<210>  17
<211>  26
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Synthetic: 26874-29_22


<220>
<221>  misc_feature
<222>  (1)..(26)
<223>  Every n is a C-5 modified pyrimidine such as Tyr-dU or Nap-dC - 
       see specification as filed for detailed description of 
       substitutions and preferred embodiments

<400>  17
nannangngn nnganngnnn ggangg                                            26


<210>  18
<211>  25
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Synthetic: 26874-29_23


<220>
<221>  misc_feature
<222>  (1)..(25)
<223>  Every n is a C-5 modified pyrimidine such as Tyr-dU or Nap-dC - 
       see specification as filed for detailed description of 
       substitutions and preferred embodiments

<400>  18
annangngnn nganngnnng gangg                                             25


<210>  19
<211>  25
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Synthetic: 26874-29_24


<220>
<221>  misc_feature
<222>  (1)..(25)
<223>  Every n is a C-5 modified pyrimidine such as Tyr-dU or Nap-dC - 
       see specification as filed for detailed description of 
       substitutions and preferred embodiments

<400>  19
nannangngn nnganngnnn ggang                                             25


<210>  20
<211>  24
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Synthetic: 26874-29_25


<220>
<221>  misc_feature
<222>  (1)..(24)
<223>  Every n is a C-5 modified pyrimidine such as Tyr-dU or Nap-dC - 
       see specification as filed for detailed description of 
       substitutions and preferred embodiments

<400>  20
annangngnn nganngnnng gang                                              24


<210>  21
<211>  223
<212>  PRT
<213>  SARS-CoV-2


<220>
<221>  misc_feature
<222>  (1)..(223)
<223>  Spike RBD

<400>  21

Arg Val Gln Pro Thr Glu Ser Ile Val Arg Phe Pro Asn Ile Thr Asn 
1               5                   10                  15      


Leu Cys Pro Phe Gly Glu Val Phe Asn Ala Thr Arg Phe Ala Ser Val 
            20                  25                  30          


Tyr Ala Trp Asn Arg Lys Arg Ile Ser Asn Cys Val Ala Asp Tyr Ser 
        35                  40                  45              


Val Leu Tyr Asn Ser Ala Ser Phe Ser Thr Phe Lys Cys Tyr Gly Val 
    50                  55                  60                  


Ser Pro Thr Lys Leu Asn Asp Leu Cys Phe Thr Asn Val Tyr Ala Asp 
65                  70                  75                  80  


Ser Phe Val Ile Arg Gly Asp Glu Val Arg Gln Ile Ala Pro Gly Gln 
                85                  90                  95      


Thr Gly Lys Ile Ala Asp Tyr Asn Tyr Lys Leu Pro Asp Asp Phe Thr 
            100                 105                 110         


Gly Cys Val Ile Ala Trp Asn Ser Asn Asn Leu Asp Ser Lys Val Gly 
        115                 120                 125             


Gly Asn Tyr Asn Tyr Leu Tyr Arg Leu Phe Arg Lys Ser Asn Leu Lys 
    130                 135                 140                 


Pro Phe Glu Arg Asp Ile Ser Thr Glu Ile Tyr Gln Ala Gly Ser Thr 
145                 150                 155                 160 


Pro Cys Asn Gly Val Glu Gly Phe Asn Cys Tyr Phe Pro Leu Gln Ser 
                165                 170                 175     


Tyr Gly Phe Gln Pro Thr Asn Gly Val Gly Tyr Gln Pro Tyr Arg Val 
            180                 185                 190         


Val Val Leu Ser Phe Glu Leu Leu His Ala Pro Ala Thr Val Cys Gly 
        195                 200                 205             


Pro Lys Lys Ser Thr Asn Leu Val Lys Asn Lys Cys Val Asn Phe 
    210                 215                 220             


<210>  22
<211>  666
<212>  PRT
<213>  SARS-CoV-2


<220>
<221>  misc_feature
<222>  (1)..(666)
<223>  Spike S1

<400>  22

Val Asn Leu Thr Thr Arg Thr Gln Leu Pro Pro Ala Tyr Thr Asn Ser 
1               5                   10                  15      


Phe Thr Arg Gly Val Tyr Tyr Pro Asp Lys Val Phe Arg Ser Ser Val 
            20                  25                  30          


Leu His Ser Thr Gln Asp Leu Phe Leu Pro Phe Phe Ser Asn Val Thr 
        35                  40                  45              


Trp Phe His Ala Ile His Val Ser Gly Thr Asn Gly Thr Lys Arg Phe 
    50                  55                  60                  


Asp Asn Pro Val Leu Pro Phe Asn Asp Gly Val Tyr Phe Ala Ser Thr 
65                  70                  75                  80  


Glu Lys Ser Asn Ile Ile Arg Gly Trp Ile Phe Gly Thr Thr Leu Asp 
                85                  90                  95      


Ser Lys Thr Gln Ser Leu Leu Ile Val Asn Asn Ala Thr Asn Val Val 
            100                 105                 110         


Ile Lys Val Cys Glu Phe Gln Phe Cys Asn Asp Pro Phe Leu Gly Val 
        115                 120                 125             


Tyr Tyr His Lys Asn Asn Lys Ser Trp Met Glu Ser Glu Phe Arg Val 
    130                 135                 140                 


Tyr Ser Ser Ala Asn Asn Cys Thr Phe Glu Tyr Val Ser Gln Pro Phe 
145                 150                 155                 160 


Leu Met Asp Leu Glu Gly Lys Gln Gly Asn Phe Lys Asn Leu Arg Glu 
                165                 170                 175     


Phe Val Phe Lys Asn Ile Asp Gly Tyr Phe Lys Ile Tyr Ser Lys His 
            180                 185                 190         


Thr Pro Ile Asn Leu Val Arg Asp Leu Pro Gln Gly Phe Ser Ala Leu 
        195                 200                 205             


Glu Pro Leu Val Asp Leu Pro Ile Gly Ile Asn Ile Thr Arg Phe Gln 
    210                 215                 220                 


Thr Leu Leu Ala Leu His Arg Ser Tyr Leu Thr Pro Gly Asp Ser Ser 
225                 230                 235                 240 


Ser Gly Trp Thr Ala Gly Ala Ala Ala Tyr Tyr Val Gly Tyr Leu Gln 
                245                 250                 255     


Pro Arg Thr Phe Leu Leu Lys Tyr Asn Glu Asn Gly Thr Ile Thr Asp 
            260                 265                 270         


Ala Val Asp Cys Ala Leu Asp Pro Leu Ser Glu Thr Lys Cys Thr Leu 
        275                 280                 285             


Lys Ser Phe Thr Val Glu Lys Gly Ile Tyr Gln Thr Ser Asn Phe Arg 
    290                 295                 300                 


Val Gln Pro Thr Glu Ser Ile Val Arg Phe Pro Asn Ile Thr Asn Leu 
305                 310                 315                 320 


Cys Pro Phe Gly Glu Val Phe Asn Ala Thr Arg Phe Ala Ser Val Tyr 
                325                 330                 335     


Ala Trp Asn Arg Lys Arg Ile Ser Asn Cys Val Ala Asp Tyr Ser Val 
            340                 345                 350         


Leu Tyr Asn Ser Ala Ser Phe Ser Thr Phe Lys Cys Tyr Gly Val Ser 
        355                 360                 365             


Pro Thr Lys Leu Asn Asp Leu Cys Phe Thr Asn Val Tyr Ala Asp Ser 
    370                 375                 380                 


Phe Val Ile Arg Gly Asp Glu Val Arg Gln Ile Ala Pro Gly Gln Thr 
385                 390                 395                 400 


Gly Lys Ile Ala Asp Tyr Asn Tyr Lys Leu Pro Asp Asp Phe Thr Gly 
                405                 410                 415     


Cys Val Ile Ala Trp Asn Ser Asn Asn Leu Asp Ser Lys Val Gly Gly 
            420                 425                 430         


Asn Tyr Asn Tyr Leu Tyr Arg Leu Phe Arg Lys Ser Asn Leu Lys Pro 
        435                 440                 445             


Phe Glu Arg Asp Ile Ser Thr Glu Ile Tyr Gln Ala Gly Ser Thr Pro 
    450                 455                 460                 


Cys Asn Gly Val Glu Gly Phe Asn Cys Tyr Phe Pro Leu Gln Ser Tyr 
465                 470                 475                 480 


Gly Phe Gln Pro Thr Asn Gly Val Gly Tyr Gln Pro Tyr Arg Val Val 
                485                 490                 495     


Val Leu Ser Phe Glu Leu Leu His Ala Pro Ala Thr Val Cys Gly Pro 
            500                 505                 510         


Lys Lys Ser Thr Asn Leu Val Lys Asn Lys Cys Val Asn Phe Asn Phe 
        515                 520                 525             


Asn Gly Leu Thr Gly Thr Gly Val Leu Thr Glu Ser Asn Lys Lys Phe 
    530                 535                 540                 


Leu Pro Phe Gln Gln Phe Gly Arg Asp Ile Ala Asp Thr Thr Asp Ala 
545                 550                 555                 560 


Val Arg Asp Pro Gln Thr Leu Glu Ile Leu Asp Ile Thr Pro Cys Ser 
                565                 570                 575     


Phe Gly Gly Val Ser Val Ile Thr Pro Gly Thr Asn Thr Ser Asn Gln 
            580                 585                 590         


Val Ala Val Leu Tyr Gln Asp Val Asn Cys Thr Glu Val Pro Val Ala 
        595                 600                 605             


Ile His Ala Asp Gln Leu Thr Pro Thr Trp Arg Val Tyr Ser Thr Gly 
    610                 615                 620                 


Ser Asn Val Phe Gln Thr Arg Ala Gly Cys Leu Ile Gly Ala Glu His 
625                 630                 635                 640 


Val Asn Asn Ser Tyr Glu Cys Asp Ile Pro Ile Gly Ala Gly Ile Cys 
                645                 650                 655     


Ala Ser Tyr Gln Thr Gln Thr Asn Ser Pro 
            660                 665     


<210>  23
<211>  1197
<212>  PRT
<213>  SARS-CoV-2


<220>
<221>  misc_feature
<222>  (1)..(1197)
<223>  Spike S1 & S2 ECD

<400>  23

Val Asn Leu Thr Thr Arg Thr Gln Leu Pro Pro Ala Tyr Thr Asn Ser 
1               5                   10                  15      


Phe Thr Arg Gly Val Tyr Tyr Pro Asp Lys Val Phe Arg Ser Ser Val 
            20                  25                  30          


Leu His Ser Thr Gln Asp Leu Phe Leu Pro Phe Phe Ser Asn Val Thr 
        35                  40                  45              


Trp Phe His Ala Ile His Val Ser Gly Thr Asn Gly Thr Lys Arg Phe 
    50                  55                  60                  


Asp Asn Pro Val Leu Pro Phe Asn Asp Gly Val Tyr Phe Ala Ser Thr 
65                  70                  75                  80  


Glu Lys Ser Asn Ile Ile Arg Gly Trp Ile Phe Gly Thr Thr Leu Asp 
                85                  90                  95      


Ser Lys Thr Gln Ser Leu Leu Ile Val Asn Asn Ala Thr Asn Val Val 
            100                 105                 110         


Ile Lys Val Cys Glu Phe Gln Phe Cys Asn Asp Pro Phe Leu Gly Val 
        115                 120                 125             


Tyr Tyr His Lys Asn Asn Lys Ser Trp Met Glu Ser Glu Phe Arg Val 
    130                 135                 140                 


Tyr Ser Ser Ala Asn Asn Cys Thr Phe Glu Tyr Val Ser Gln Pro Phe 
145                 150                 155                 160 


Leu Met Asp Leu Glu Gly Lys Gln Gly Asn Phe Lys Asn Leu Arg Glu 
                165                 170                 175     


Phe Val Phe Lys Asn Ile Asp Gly Tyr Phe Lys Ile Tyr Ser Lys His 
            180                 185                 190         


Thr Pro Ile Asn Leu Val Arg Asp Leu Pro Gln Gly Phe Ser Ala Leu 
        195                 200                 205             


Glu Pro Leu Val Asp Leu Pro Ile Gly Ile Asn Ile Thr Arg Phe Gln 
    210                 215                 220                 


Thr Leu Leu Ala Leu His Arg Ser Tyr Leu Thr Pro Gly Asp Ser Ser 
225                 230                 235                 240 


Ser Gly Trp Thr Ala Gly Ala Ala Ala Tyr Tyr Val Gly Tyr Leu Gln 
                245                 250                 255     


Pro Arg Thr Phe Leu Leu Lys Tyr Asn Glu Asn Gly Thr Ile Thr Asp 
            260                 265                 270         


Ala Val Asp Cys Ala Leu Asp Pro Leu Ser Glu Thr Lys Cys Thr Leu 
        275                 280                 285             


Lys Ser Phe Thr Val Glu Lys Gly Ile Tyr Gln Thr Ser Asn Phe Arg 
    290                 295                 300                 


Val Gln Pro Thr Glu Ser Ile Val Arg Phe Pro Asn Ile Thr Asn Leu 
305                 310                 315                 320 


Cys Pro Phe Gly Glu Val Phe Asn Ala Thr Arg Phe Ala Ser Val Tyr 
                325                 330                 335     


Ala Trp Asn Arg Lys Arg Ile Ser Asn Cys Val Ala Asp Tyr Ser Val 
            340                 345                 350         


Leu Tyr Asn Ser Ala Ser Phe Ser Thr Phe Lys Cys Tyr Gly Val Ser 
        355                 360                 365             


Pro Thr Lys Leu Asn Asp Leu Cys Phe Thr Asn Val Tyr Ala Asp Ser 
    370                 375                 380                 


Phe Val Ile Arg Gly Asp Glu Val Arg Gln Ile Ala Pro Gly Gln Thr 
385                 390                 395                 400 


Gly Lys Ile Ala Asp Tyr Asn Tyr Lys Leu Pro Asp Asp Phe Thr Gly 
                405                 410                 415     


Cys Val Ile Ala Trp Asn Ser Asn Asn Leu Asp Ser Lys Val Gly Gly 
            420                 425                 430         


Asn Tyr Asn Tyr Leu Tyr Arg Leu Phe Arg Lys Ser Asn Leu Lys Pro 
        435                 440                 445             


Phe Glu Arg Asp Ile Ser Thr Glu Ile Tyr Gln Ala Gly Ser Thr Pro 
    450                 455                 460                 


Cys Asn Gly Val Glu Gly Phe Asn Cys Tyr Phe Pro Leu Gln Ser Tyr 
465                 470                 475                 480 


Gly Phe Gln Pro Thr Asn Gly Val Gly Tyr Gln Pro Tyr Arg Val Val 
                485                 490                 495     


Val Leu Ser Phe Glu Leu Leu His Ala Pro Ala Thr Val Cys Gly Pro 
            500                 505                 510         


Lys Lys Ser Thr Asn Leu Val Lys Asn Lys Cys Val Asn Phe Asn Phe 
        515                 520                 525             


Asn Gly Leu Thr Gly Thr Gly Val Leu Thr Glu Ser Asn Lys Lys Phe 
    530                 535                 540                 


Leu Pro Phe Gln Gln Phe Gly Arg Asp Ile Ala Asp Thr Thr Asp Ala 
545                 550                 555                 560 


Val Arg Asp Pro Gln Thr Leu Glu Ile Leu Asp Ile Thr Pro Cys Ser 
                565                 570                 575     


Phe Gly Gly Val Ser Val Ile Thr Pro Gly Thr Asn Thr Ser Asn Gln 
            580                 585                 590         


Val Ala Val Leu Tyr Gln Asp Val Asn Cys Thr Glu Val Pro Val Ala 
        595                 600                 605             


Ile His Ala Asp Gln Leu Thr Pro Thr Trp Arg Val Tyr Ser Thr Gly 
    610                 615                 620                 


Ser Asn Val Phe Gln Thr Arg Ala Gly Cys Leu Ile Gly Ala Glu His 
625                 630                 635                 640 


Val Asn Asn Ser Tyr Glu Cys Asp Ile Pro Ile Gly Ala Gly Ile Cys 
                645                 650                 655     


Ala Ser Tyr Gln Thr Gln Thr Asn Ser Pro Arg Arg Ala Arg Ser Val 
            660                 665                 670         


Ala Ser Gln Ser Ile Ile Ala Tyr Thr Met Ser Leu Gly Ala Glu Asn 
        675                 680                 685             


Ser Val Ala Tyr Ser Asn Asn Ser Ile Ala Ile Pro Thr Asn Phe Thr 
    690                 695                 700                 


Ile Ser Val Thr Thr Glu Ile Leu Pro Val Ser Met Thr Lys Thr Ser 
705                 710                 715                 720 


Val Asp Cys Thr Met Tyr Ile Cys Gly Asp Ser Thr Glu Cys Ser Asn 
                725                 730                 735     


Leu Leu Leu Gln Tyr Gly Ser Phe Cys Thr Gln Leu Asn Arg Ala Leu 
            740                 745                 750         


Thr Gly Ile Ala Val Glu Gln Asp Lys Asn Thr Gln Glu Val Phe Ala 
        755                 760                 765             


Gln Val Lys Gln Ile Tyr Lys Thr Pro Pro Ile Lys Asp Phe Gly Gly 
    770                 775                 780                 


Phe Asn Phe Ser Gln Ile Leu Pro Asp Pro Ser Lys Pro Ser Lys Arg 
785                 790                 795                 800 


Ser Phe Ile Glu Asp Leu Leu Phe Asn Lys Val Thr Leu Asp Ala Gly 
                805                 810                 815     


Phe Ile Lys Gln Tyr Gly Asp Cys Leu Gly Asp Ile Ala Ala Arg Asp 
            820                 825                 830         


Leu Ile Cys Ala Gln Lys Phe Asn Gly Leu Thr Val Leu Pro Pro Leu 
        835                 840                 845             


Leu Thr Asp Glu Met Ile Ala Gln Tyr Thr Ser Ala Leu Leu Ala Gly 
    850                 855                 860                 


Thr Ile Thr Ser Gly Trp Thr Phe Gly Ala Gly Ala Ala Leu Gln Ile 
865                 870                 875                 880 


Pro Phe Ala Met Gln Met Ala Tyr Arg Phe Asn Gly Ile Gly Val Thr 
                885                 890                 895     


Gln Asn Val Leu Tyr Glu Asn Gln Lys Leu Ile Ala Asn Gln Phe Asn 
            900                 905                 910         


Ser Ala Ile Gly Lys Ile Gln Asp Ser Leu Ser Ser Thr Ala Ser Ala 
        915                 920                 925             


Leu Gly Lys Leu Gln Asp Val Val Asn Gln Asn Ala Gln Ala Leu Asn 
    930                 935                 940                 


Thr Leu Val Lys Gln Leu Ser Ser Asn Phe Gly Ala Ile Ser Ser Val 
945                 950                 955                 960 


Leu Asn Asp Ile Leu Ser Arg Leu Asp Lys Val Glu Ala Glu Val Gln 
                965                 970                 975     


Ile Asp Arg Leu Ile Thr Gly Arg Leu Gln Ser Leu Gln Thr Tyr Val 
            980                 985                 990         


Thr Gln Gln Leu Ile Arg Ala Ala  Glu Ile Arg Ala Ser  Ala Asn Leu 
        995                 1000                 1005             


Ala Ala  Thr Lys Met Ser Glu  Cys Val Leu Gly Gln  Ser Lys Arg 
    1010                 1015                 1020             


Val Asp  Phe Cys Gly Lys Gly  Tyr His Leu Met Ser  Phe Pro Gln 
    1025                 1030                 1035             


Ser Ala  Pro His Gly Val Val  Phe Leu His Val Thr  Tyr Val Pro 
    1040                 1045                 1050             


Ala Gln  Glu Lys Asn Phe Thr  Thr Ala Pro Ala Ile  Cys His Asp 
    1055                 1060                 1065             


Gly Lys  Ala His Phe Pro Arg  Glu Gly Val Phe Val  Ser Asn Gly 
    1070                 1075                 1080             


Thr His  Trp Phe Val Thr Gln  Arg Asn Phe Tyr Glu  Pro Gln Ile 
    1085                 1090                 1095             


Ile Thr  Thr Asp Asn Thr Phe  Val Ser Gly Asn Cys  Asp Val Val 
    1100                 1105                 1110             


Ile Gly  Ile Val Asn Asn Thr  Val Tyr Asp Pro Leu  Gln Pro Glu 
    1115                 1120                 1125             


Leu Asp  Ser Phe Lys Glu Glu  Leu Asp Lys Tyr Phe  Lys Asn His 
    1130                 1135                 1140             


Thr Ser  Pro Asp Val Asp Leu  Gly Asp Ile Ser Gly  Ile Asn Ala 
    1145                 1150                 1155             


Ser Val  Val Asn Ile Gln Lys  Glu Ile Asp Arg Leu  Asn Glu Val 
    1160                 1165                 1170             


Ala Lys  Asn Leu Asn Glu Ser  Leu Ile Asp Leu Gln  Glu Leu Gly 
    1175                 1180                 1185             


Lys Tyr  Glu Gln Tyr Ile Lys  Trp Pro 
    1190                 1195         


<210>  24
<211>  1135
<212>  PRT
<213>  SARS-CoV-2


<220>
<221>  misc_feature
<222>  (1)..(1135)
<223>  Spike S1 & S2 ECD stable trimer

<400>  24

Val Asn Leu Thr Thr Arg Thr Gln Leu Pro Pro Ala Tyr Thr Asn Ser 
1               5                   10                  15      


Phe Thr Arg Gly Val Tyr Tyr Pro Asp Lys Val Phe Arg Ser Ser Val 
            20                  25                  30          


Leu His Ser Thr Gln Asp Leu Phe Leu Pro Phe Phe Ser Asn Val Thr 
        35                  40                  45              


Trp Phe His Ala Ile His Val Ser Gly Thr Asn Gly Thr Lys Arg Phe 
    50                  55                  60                  


Asp Asn Pro Val Leu Pro Phe Asn Asp Gly Val Tyr Phe Ala Ser Thr 
65                  70                  75                  80  


Glu Lys Ser Asn Ile Ile Arg Gly Trp Ile Phe Gly Thr Thr Leu Asp 
                85                  90                  95      


Ser Lys Thr Gln Ser Leu Leu Ile Val Asn Asn Ala Thr Asn Val Val 
            100                 105                 110         


Ile Lys Val Cys Glu Phe Gln Phe Cys Asn Asp Pro Phe Leu Gly Val 
        115                 120                 125             


Tyr Tyr His Lys Asn Asn Lys Ser Trp Met Glu Ser Glu Phe Arg Val 
    130                 135                 140                 


Tyr Ser Ser Ala Asn Asn Cys Thr Phe Glu Tyr Val Ser Gln Pro Phe 
145                 150                 155                 160 


Leu Met Asp Leu Glu Gly Lys Gln Gly Asn Phe Lys Asn Leu Arg Glu 
                165                 170                 175     


Phe Val Phe Lys Asn Ile Asp Gly Tyr Phe Lys Ile Tyr Ser Lys His 
            180                 185                 190         


Thr Pro Ile Asn Leu Val Arg Asp Leu Pro Gln Gly Phe Ser Ala Leu 
        195                 200                 205             


Glu Pro Leu Val Asp Leu Pro Ile Gly Ile Asn Ile Thr Arg Phe Gln 
    210                 215                 220                 


Thr Leu Leu Ala Leu His Arg Ser Tyr Leu Thr Pro Gly Asp Ser Ser 
225                 230                 235                 240 


Ser Gly Trp Thr Ala Gly Ala Ala Ala Tyr Tyr Val Gly Tyr Leu Gln 
                245                 250                 255     


Pro Arg Thr Phe Leu Leu Lys Tyr Asn Glu Asn Gly Thr Ile Thr Asp 
            260                 265                 270         


Ala Val Asp Cys Ala Leu Asp Pro Leu Ser Glu Thr Lys Cys Thr Leu 
        275                 280                 285             


Lys Ser Phe Thr Val Glu Lys Gly Ile Tyr Gln Thr Ser Asn Phe Arg 
    290                 295                 300                 


Val Gln Pro Thr Glu Ser Ile Val Arg Phe Pro Asn Ile Thr Asn Leu 
305                 310                 315                 320 


Cys Pro Phe Gly Glu Val Phe Asn Ala Thr Arg Phe Ala Ser Val Tyr 
                325                 330                 335     


Ala Trp Asn Arg Lys Arg Ile Ser Asn Cys Val Ala Asp Tyr Ser Val 
            340                 345                 350         


Leu Tyr Asn Ser Ala Ser Phe Ser Thr Phe Lys Cys Tyr Gly Val Ser 
        355                 360                 365             


Pro Thr Lys Leu Asn Asp Leu Cys Phe Thr Asn Val Tyr Ala Asp Ser 
    370                 375                 380                 


Phe Val Ile Arg Gly Asp Glu Val Arg Gln Ile Ala Pro Gly Gln Thr 
385                 390                 395                 400 


Gly Lys Ile Ala Asp Tyr Asn Tyr Lys Leu Pro Asp Asp Phe Thr Gly 
                405                 410                 415     


Cys Val Ile Ala Trp Asn Ser Asn Asn Leu Asp Ser Lys Val Gly Gly 
            420                 425                 430         


Asn Tyr Asn Tyr Leu Tyr Arg Leu Phe Arg Lys Ser Asn Leu Lys Pro 
        435                 440                 445             


Phe Glu Arg Asp Ile Ser Thr Glu Ile Tyr Gln Ala Gly Ser Thr Pro 
    450                 455                 460                 


Cys Asn Gly Val Glu Gly Phe Asn Cys Tyr Phe Pro Leu Gln Ser Tyr 
465                 470                 475                 480 


Gly Phe Gln Pro Thr Asn Gly Val Gly Tyr Gln Pro Tyr Arg Val Val 
                485                 490                 495     


Val Leu Ser Phe Glu Leu Leu His Ala Pro Ala Thr Val Cys Gly Pro 
            500                 505                 510         


Lys Lys Ser Thr Asn Leu Val Lys Asn Lys Cys Val Asn Phe Asn Phe 
        515                 520                 525             


Asn Gly Leu Thr Gly Thr Gly Val Leu Thr Glu Ser Asn Lys Lys Phe 
    530                 535                 540                 


Leu Pro Phe Gln Gln Phe Gly Arg Asp Ile Ala Asp Thr Thr Asp Ala 
545                 550                 555                 560 


Val Arg Asp Pro Gln Thr Leu Glu Ile Leu Asp Ile Thr Pro Cys Ser 
                565                 570                 575     


Phe Gly Gly Val Ser Val Ile Thr Pro Gly Thr Asn Thr Ser Asn Gln 
            580                 585                 590         


Val Ala Val Leu Tyr Gln Asp Val Asn Cys Thr Glu Val Pro Val Ala 
        595                 600                 605             


Ile His Ala Asp Gln Leu Thr Pro Thr Trp Arg Val Tyr Ser Thr Gly 
    610                 615                 620                 


Ser Asn Val Phe Gln Thr Arg Ala Gly Cys Leu Ile Gly Ala Glu His 
625                 630                 635                 640 


Val Asn Asn Ser Tyr Glu Cys Asp Ile Pro Ile Gly Ala Gly Ile Cys 
                645                 650                 655     


Ala Ser Tyr Gln Thr Gln Thr Asn Ser Pro Arg Ala Ala Ala Ser Val 
            660                 665                 670         


Ala Ser Gln Ser Ile Ile Ala Tyr Thr Met Ser Leu Gly Ala Glu Asn 
        675                 680                 685             


Ser Val Ala Tyr Ser Asn Asn Ser Ile Ala Ile Pro Thr Asn Phe Thr 
    690                 695                 700                 


Ile Ser Val Thr Thr Glu Ile Leu Pro Val Ser Met Thr Lys Thr Ser 
705                 710                 715                 720 


Val Asp Cys Thr Met Tyr Ile Cys Gly Asp Ser Thr Glu Cys Ser Asn 
                725                 730                 735     


Leu Leu Leu Gln Tyr Gly Ser Phe Cys Thr Gln Leu Asn Arg Ala Leu 
            740                 745                 750         


Thr Gly Ile Ala Val Glu Gln Asp Lys Asn Thr Gln Glu Val Phe Ala 
        755                 760                 765             


Gln Val Lys Gln Ile Tyr Lys Thr Pro Pro Ile Lys Asp Phe Gly Gly 
    770                 775                 780                 


Phe Asn Phe Ser Gln Ile Leu Pro Asp Pro Ser Lys Pro Ser Lys Arg 
785                 790                 795                 800 


Ser Pro Ile Glu Asp Leu Leu Phe Asn Lys Val Thr Leu Ala Asp Ala 
                805                 810                 815     


Gly Phe Ile Lys Gln Tyr Gly Asp Cys Leu Gly Asp Ile Ala Ala Arg 
            820                 825                 830         


Asp Leu Ile Cys Ala Gln Lys Phe Asn Gly Leu Thr Val Leu Pro Pro 
        835                 840                 845             


Leu Leu Thr Asp Glu Met Ile Ala Gln Tyr Thr Ser Ala Leu Leu Ala 
    850                 855                 860                 


Gly Thr Ile Thr Ser Gly Trp Thr Phe Gly Ala Gly Pro Ala Leu Gln 
865                 870                 875                 880 


Ile Pro Phe Pro Met Gln Met Ala Tyr Arg Phe Asn Gly Ile Gly Val 
                885                 890                 895     


Thr Gln Asn Val Leu Tyr Glu Asn Gln Lys Leu Ile Ala Asn Gln Phe 
            900                 905                 910         


Asn Ser Ala Ile Gly Lys Ile Gln Asp Ser Leu Ser Ser Thr Pro Ser 
        915                 920                 925             


Ala Leu Gly Lys Leu Gln Asp Val Val Asn Gln Asn Ala Gln Ala Leu 
    930                 935                 940                 


Asn Thr Leu Val Lys Gln Leu Ser Ser Asn Phe Gly Ala Ile Ser Ser 
945                 950                 955                 960 


Val Leu Asn Asp Ile Leu Ser Arg Leu Asp Pro Pro Glu Ala Glu Val 
                965                 970                 975     


Gln Ile Asp Arg Leu Ile Thr Gly Arg Leu Gln Ser Leu Gln Thr Tyr 
            980                 985                 990         


Val Thr Gln Gln Leu Ile Arg Ala  Ala Glu Ile Arg Ala  Ser Ala Asn 
        995                 1000                 1005             


Leu Ala  Ala Thr Lys Met Ser  Glu Cys Val Leu Gly  Gln Ser Lys 
    1010                 1015                 1020             


Arg Val  Asp Phe Cys Gly Lys  Gly Tyr His Leu Met  Ser Phe Pro 
    1025                 1030                 1035             


Gln Ser  Ala Pro His Gly Val  Val Phe Leu His Val  Thr Tyr Val 
    1040                 1045                 1050             


Pro Ala  Gln Glu Lys Asn Phe  Thr Thr Ala Pro Ala  Ile Cys His 
    1055                 1060                 1065             


Asp Gly  Lys Ala His Phe Pro  Arg Glu Gly Val Phe  Val Ser Asn 
    1070                 1075                 1080             


Gly Thr  His Trp Phe Val Thr  Gln Arg Asn Phe Tyr  Glu Pro Gln 
    1085                 1090                 1095             


Ile Ile  Thr Thr Asp Asn Thr  Phe Val Ser Gly Asn  Cys Asp Val 
    1100                 1105                 1110             


Val Ile  Gly Ile Val Asn Asn  Thr Val Tyr Asp Pro  Leu Gln Pro 
    1115                 1120                 1125             


Glu Leu  Asp Ser Phe Lys Glu  
    1130                 1135 


<210>  25
<211>  669
<212>  PRT
<213>  SARS-CoV-2


<220>
<221>  misc_feature
<222>  (1)..(669)
<223>  Spike S1 D614G

<400>  25

Val Asn Leu Thr Thr Arg Thr Gln Leu Pro Pro Ala Tyr Thr Asn Ser 
1               5                   10                  15      


Phe Thr Arg Gly Val Tyr Tyr Pro Asp Lys Val Phe Arg Ser Ser Val 
            20                  25                  30          


Leu His Ser Thr Gln Asp Leu Phe Leu Pro Phe Phe Ser Asn Val Thr 
        35                  40                  45              


Trp Phe His Ala Ile His Val Ser Gly Thr Asn Gly Thr Lys Arg Phe 
    50                  55                  60                  


Asp Asn Pro Val Leu Pro Phe Asn Asp Gly Val Tyr Phe Ala Ser Thr 
65                  70                  75                  80  


Glu Lys Ser Asn Ile Ile Arg Gly Trp Ile Phe Gly Thr Thr Leu Asp 
                85                  90                  95      


Ser Lys Thr Gln Ser Leu Leu Ile Val Asn Asn Ala Thr Asn Val Val 
            100                 105                 110         


Ile Lys Val Cys Glu Phe Gln Phe Cys Asn Asp Pro Phe Leu Gly Val 
        115                 120                 125             


Tyr Tyr His Lys Asn Asn Lys Ser Trp Met Glu Ser Glu Phe Arg Val 
    130                 135                 140                 


Tyr Ser Ser Asn Asn Cys Thr Phe Glu Tyr Val Ser Gln Pro Phe Leu 
145                 150                 155                 160 


Met Asp Leu Glu Gly Lys Gln Gly Asn Phe Lys Asn Leu Arg Glu Phe 
                165                 170                 175     


Val Phe Lys Asn Ile Asp Gly Tyr Phe Lys Ile Tyr Ser Lys His Thr 
            180                 185                 190         


Pro Ile Asn Leu Val Arg Asp Leu Pro Gln Gly Phe Ser Ala Leu Glu 
        195                 200                 205             


Pro Leu Val Asp Leu Pro Ile Gly Ile Asn Ile Thr Arg Phe Gln Thr 
    210                 215                 220                 


Leu Leu Ala Leu His Arg Ser Tyr Leu Thr Pro Gly Asp Ser Ser Ser 
225                 230                 235                 240 


Gly Trp Thr Ala Gly Ala Ala Ala Tyr Tyr Val Gly Tyr Leu Gln Pro 
                245                 250                 255     


Arg Thr Phe Leu Leu Lys Tyr Asn Glu Asn Gly Thr Ile Thr Asp Ala 
            260                 265                 270         


Val Asp Cys Ala Leu Asp Pro Leu Ser Glu Thr Lys Cys Thr Leu Lys 
        275                 280                 285             


Ser Phe Thr Val Glu Lys Gly Ile Tyr Gln Thr Ser Asn Phe Arg Val 
    290                 295                 300                 


Gln Pro Thr Glu Ser Ile Val Arg Phe Pro Asn Ile Thr Asn Leu Cys 
305                 310                 315                 320 


Pro Phe Gly Glu Val Phe Asn Ala Thr Arg Phe Ala Ser Val Tyr Ala 
                325                 330                 335     


Trp Asn Arg Lys Arg Ile Ser Asn Cys Val Ala Asp Tyr Ser Val Leu 
            340                 345                 350         


Tyr Asn Ser Ala Ser Phe Ser Thr Phe Lys Cys Tyr Gly Val Ser Pro 
        355                 360                 365             


Thr Lys Leu Asn Asp Leu Cys Phe Thr Asn Val Tyr Ala Asp Ser Phe 
    370                 375                 380                 


Val Ile Arg Gly Asp Glu Val Arg Gln Ile Ala Pro Gly Gln Thr Gly 
385                 390                 395                 400 


Lys Ile Ala Asp Tyr Asn Tyr Lys Leu Pro Asp Asp Phe Thr Gly Cys 
                405                 410                 415     


Val Ile Ala Trp Asn Ser Asn Asn Leu Asp Ser Lys Val Gly Gly Asn 
            420                 425                 430         


Tyr Asn Tyr Leu Tyr Arg Leu Phe Arg Lys Ser Asn Leu Lys Pro Phe 
        435                 440                 445             


Glu Arg Asp Ile Ser Thr Glu Ile Tyr Gln Ala Gly Ser Thr Pro Cys 
    450                 455                 460                 


Asn Gly Val Glu Gly Phe Asn Cys Tyr Phe Pro Leu Gln Ser Tyr Gly 
465                 470                 475                 480 


Phe Gln Pro Thr Asn Gly Val Gly Tyr Gln Pro Tyr Arg Val Val Val 
                485                 490                 495     


Leu Ser Phe Glu Leu Leu His Ala Pro Ala Thr Val Cys Gly Pro Lys 
            500                 505                 510         


Lys Ser Thr Asn Leu Val Lys Asn Lys Cys Val Asn Phe Asn Phe Asn 
        515                 520                 525             


Gly Leu Thr Gly Thr Gly Val Leu Thr Glu Ser Asn Lys Lys Phe Leu 
    530                 535                 540                 


Pro Phe Gln Gln Phe Gly Arg Asp Ile Ala Asp Thr Thr Asp Ala Val 
545                 550                 555                 560 


Arg Asp Pro Gln Thr Leu Glu Ile Leu Asp Ile Thr Pro Cys Ser Phe 
                565                 570                 575     


Gly Gly Val Ser Val Ile Thr Pro Gly Thr Asn Thr Ser Asn Gln Val 
            580                 585                 590         


Ala Val Leu Tyr Gln Gly Val Asn Cys Thr Glu Val Pro Val Ala Ile 
        595                 600                 605             


His Ala Asp Gln Leu Thr Pro Thr Trp Arg Val Tyr Ser Thr Gly Ser 
    610                 615                 620                 


Asn Val Phe Gln Thr Arg Ala Gly Cys Leu Ile Gly Ala Glu His Val 
625                 630                 635                 640 


Asn Asn Ser Tyr Glu Cys Asp Ile Pro Ile Gly Ala Gly Ile Cys Ala 
                645                 650                 655     


Ser Tyr Gln Thr Gln Thr Asn Ser Pro Arg Arg Ala Arg 
            660                 665                 


<210>  26
<211>  223
<212>  PRT
<213>  SARS-CoV-2


<220>
<221>  misc_feature
<222>  (1)..(223)
<223>  Spike RBD N501Y

<400>  26

Arg Val Gln Pro Thr Glu Ser Ile Val Arg Phe Pro Asn Ile Thr Asn 
1               5                   10                  15      


Leu Cys Pro Phe Gly Glu Val Phe Asn Ala Thr Arg Phe Ala Ser Val 
            20                  25                  30          


Tyr Ala Trp Asn Arg Lys Arg Ile Ser Asn Cys Val Ala Asp Tyr Ser 
        35                  40                  45              


Val Leu Tyr Asn Ser Ala Ser Phe Ser Thr Phe Lys Cys Tyr Gly Val 
    50                  55                  60                  


Ser Pro Thr Lys Leu Asn Asp Leu Cys Phe Thr Asn Val Tyr Ala Asp 
65                  70                  75                  80  


Ser Phe Val Ile Arg Gly Asp Glu Val Arg Gln Ile Ala Pro Gly Gln 
                85                  90                  95      


Thr Gly Lys Ile Ala Asp Tyr Asn Tyr Lys Leu Pro Asp Asp Phe Thr 
            100                 105                 110         


Gly Cys Val Ile Ala Trp Asn Ser Asn Asn Leu Asp Ser Lys Val Gly 
        115                 120                 125             


Gly Asn Tyr Asn Tyr Leu Tyr Arg Leu Phe Arg Lys Ser Asn Leu Lys 
    130                 135                 140                 


Pro Phe Glu Arg Asp Ile Ser Thr Glu Ile Tyr Gln Ala Gly Ser Thr 
145                 150                 155                 160 


Pro Cys Asn Gly Val Glu Gly Phe Asn Cys Tyr Phe Pro Leu Gln Ser 
                165                 170                 175     


Tyr Gly Phe Gln Pro Thr Tyr Gly Val Gly Tyr Gln Pro Tyr Arg Val 
            180                 185                 190         


Val Val Leu Ser Phe Glu Leu Leu His Ala Pro Ala Thr Val Cys Gly 
        195                 200                 205             


Pro Lys Lys Ser Thr Asn Leu Val Lys Asn Lys Cys Val Asn Phe 
    210                 215                 220             


<210>  27
<211>  219
<212>  PRT
<213>  SARS-CoV-2


<220>
<221>  misc_feature
<222>  (1)..(219)
<223>  Spike RBD E484K

<400>  27

Arg Val Gln Pro Thr Glu Ser Ile Val Arg Phe Pro Asn Ile Thr Asn 
1               5                   10                  15      


Leu Cys Pro Phe Gly Glu Val Phe Asn Ala Thr Arg Phe Ala Ser Val 
            20                  25                  30          


Tyr Ala Trp Asn Arg Lys Arg Ile Ser Asn Cys Val Ala Asp Tyr Ser 
        35                  40                  45              


Val Leu Tyr Asn Ser Ala Ser Phe Ser Thr Phe Lys Cys Tyr Gly Val 
    50                  55                  60                  


Ser Pro Thr Lys Leu Asn Asp Leu Cys Phe Thr Asn Val Tyr Ala Asp 
65                  70                  75                  80  


Ser Phe Val Ile Arg Gly Asp Glu Val Arg Gln Ile Ala Pro Gly Gln 
                85                  90                  95      


Thr Gly Lys Ile Ala Asp Tyr Asn Tyr Lys Leu Pro Asp Asp Phe Thr 
            100                 105                 110         


Gly Cys Val Ile Ala Trp Asn Ser Asn Asn Leu Asp Ser Lys Val Gly 
        115                 120                 125             


Gly Asn Tyr Asn Tyr Leu Tyr Arg Leu Phe Arg Lys Ser Asn Leu Lys 
    130                 135                 140                 


Pro Phe Glu Arg Asp Ile Ser Thr Glu Ile Tyr Gln Ala Gly Ser Thr 
145                 150                 155                 160 


Pro Cys Asn Gly Val Lys Gly Phe Asn Cys Tyr Phe Pro Leu Gln Ser 
                165                 170                 175     


Tyr Gly Phe Gln Pro Thr Asn Gly Val Gly Tyr Gln Pro Tyr Arg Val 
            180                 185                 190         


Val Val Leu Ser Phe Glu Leu Leu His Ala Pro Ala Thr Val Cys Gly 
        195                 200                 205             


Pro Lys Lys Ser Thr Asn Leu Val Lys Asn Lys 
    210                 215                 


<210>  28
<211>  29
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Synthetic: 26874-29_46


<220>
<221>  misc_feature
<222>  (1)..(29)
<223>  Every n is a C-5 modified pyrimidine such as TyrdU, NapdC, ThdU, 
       O, MOEdU, 2NapdU, BTdU, POPdU, 2NEdU, iBudU, MBndU, BPEdU, FBndU,
       NapdU, TrpdU, BndU, PBndU, NEdU, PEdU, BFdU, or PPdU

<220>
<221>  misc_feature
<222>  (1)..(29)
<223>  See specification as filed for detailed description of 
       substitutions and preferred embodiments

<400>  28
ggganannan gngnnngann gnnnggang                                         29


<210>  29
<211>  29
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Synthetic: 26874-29_47


<220>
<221>  misc_feature
<222>  (1)..(29)
<223>  Every n is a C-5 modified pyrimidine such as TyrdU, NapdC, ThdU, 
       O, MOEdU, 2NapdU, BTdU, POPdU, 2NEdU, iBudU, MBndU, BPEdU, FBndU,
       NapdU, TrpdU, BndU, PBndU, NEdU, PEdU, BFdU, or PPdU

<220>
<221>  misc_feature
<222>  (1)..(29)
<223>  See specification as filed for detailed description of 
       substitutions and preferred embodiments

<400>  29
ggganannan gngnnngann gnnnggang                                         29


<210>  30
<211>  29
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Synthetic: 26874-29_48


<220>
<221>  misc_feature
<222>  (1)..(29)
<223>  Every n is a C-5 modified pyrimidine such as TyrdU, NapdC, ThdU, 
       O, MOEdU, 2NapdU, BTdU, POPdU, 2NEdU, iBudU, MBndU, BPEdU, FBndU,
       NapdU, TrpdU, BndU, PBndU, NEdU, PEdU, BFdU, or PPdU

<220>
<221>  misc_feature
<222>  (1)..(29)
<223>  See specification as filed for detailed description of 
       substitutions and preferred embodiments

<400>  30
ggganannan gngnnngann gnnnggang                                         29


<210>  31
<211>  29
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Synthetic: 26874-29_49


<220>
<221>  misc_feature
<222>  (1)..(29)
<223>  Every n is a C-5 modified pyrimidine such as TyrdU, NapdC, ThdU, 
       O, MOEdU, 2NapdU, BTdU, POPdU, 2NEdU, iBudU, MBndU, BPEdU, FBndU,
       NapdU, TrpdU, BndU, PBndU, NEdU, PEdU, BFdU, or PPdU

<220>
<221>  misc_feature
<222>  (1)..(29)
<223>  See specification as filed for detailed description of 
       substitutions and preferred embodiments

<400>  31
ggganannan gngnnngann gnnnggang                                         29


<210>  32
<211>  29
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Synthetic: 26874-29_50


<220>
<221>  misc_feature
<222>  (1)..(29)
<223>  Every n is a C-5 modified pyrimidine such as TyrdU, NapdC, ThdU, 
       O, MOEdU, 2NapdU, BTdU, POPdU, 2NEdU, iBudU, MBndU, BPEdU, FBndU,
       NapdU, TrpdU, BndU, PBndU, NEdU, PEdU, BFdU, or PPdU

<220>
<221>  misc_feature
<222>  (1)..(29)
<223>  See specification as filed for detailed description of 
       substitutions and preferred embodiments

<400>  32
ggganannan gngnnngann gnnnggang                                         29


<210>  33
<211>  29
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Synthetic: 26874-29_51


<220>
<221>  misc_feature
<222>  (1)..(29)
<223>  Every n is a C-5 modified pyrimidine such as TyrdU, NapdC, ThdU, 
       O, MOEdU, 2NapdU, BTdU, POPdU, 2NEdU, iBudU, MBndU, BPEdU, FBndU,
       NapdU, TrpdU, BndU, PBndU, NEdU, PEdU, BFdU, or PPdU

<220>
<221>  misc_feature
<222>  (1)..(29)
<223>  See specification as filed for detailed description of 
       substitutions and preferred embodiments

<400>  33
ggganannan gngnnngann gnnnggang                                         29


<210>  34
<211>  29
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Synthetic: 26874-29_52


<220>
<221>  misc_feature
<222>  (1)..(29)
<223>  Every n is a C-5 modified pyrimidine such as TyrdU, NapdC, ThdU, 
       O, MOEdU, 2NapdU, BTdU, POPdU, 2NEdU, iBudU, MBndU, BPEdU, FBndU,
       NapdU, TrpdU, BndU, PBndU, NEdU, PEdU, BFdU, or PPdU

<220>
<221>  misc_feature
<222>  (1)..(29)
<223>  See specification as filed for detailed description of 
       substitutions and preferred embodiments

<400>  34
ggganannan gngnnngann gnnnggang                                         29


<210>  35
<211>  29
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Synthetic: 26874-29_53


<220>
<221>  misc_feature
<222>  (1)..(29)
<223>  Every n is a C-5 modified pyrimidine such as TyrdU, NapdC, ThdU, 
       O, MOEdU, 2NapdU, BTdU, POPdU, 2NEdU, iBudU, MBndU, BPEdU, FBndU,
       NapdU, TrpdU, BndU, PBndU, NEdU, PEdU, BFdU, or PPdU

<220>
<221>  misc_feature
<222>  (1)..(29)
<223>  See specification as filed for detailed description of 
       substitutions and preferred embodiments

<400>  35
ggganannan gngnnngann gnnnggang                                         29


<210>  36
<211>  29
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Synthetic: 26874-29_54


<220>
<221>  misc_feature
<222>  (1)..(29)
<223>  Every n is a C-5 modified pyrimidine such as TyrdU, NapdC, ThdU, 
       O, MOEdU, 2NapdU, BTdU, POPdU, 2NEdU, iBudU, MBndU, BPEdU, FBndU,
       NapdU, TrpdU, BndU, PBndU, NEdU, PEdU, BFdU, or PPdU

<220>
<221>  misc_feature
<222>  (1)..(29)
<223>  See specification as filed for detailed description of 
       substitutions and preferred embodiments

<400>  36
ggganannan gngnnngann gnnnggang                                         29


<210>  37
<211>  29
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Synthetic: 26874-29_55


<220>
<221>  misc_feature
<222>  (1)..(29)
<223>  Every n is a C-5 modified pyrimidine such as TyrdU, NapdC, ThdU, 
       O, MOEdU, 2NapdU, BTdU, POPdU, 2NEdU, iBudU, MBndU, BPEdU, FBndU,
       NapdU, TrpdU, BndU, PBndU, NEdU, PEdU, BFdU, or PPdU

<220>
<221>  misc_feature
<222>  (1)..(29)
<223>  See specification as filed for detailed description of 
       substitutions and preferred embodiments

<400>  37
ggganannan gngnnngann gnnnggang                                         29


<210>  38
<211>  29
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Synthetic: 26874-29_56


<220>
<221>  misc_feature
<222>  (1)..(29)
<223>  Every n is a C-5 modified pyrimidine such as TyrdU, NapdC, ThdU, 
       O, MOEdU, 2NapdU, BTdU, POPdU, 2NEdU, iBudU, MBndU, BPEdU, FBndU,
       NapdU, TrpdU, BndU, PBndU, NEdU, PEdU, BFdU, or PPdU

<220>
<221>  misc_feature
<222>  (1)..(29)
<223>  See specification as filed for detailed description of 
       substitutions and preferred embodiments

<400>  38
ggganannan gngnnngann gnnnggang                                         29


<210>  39
<211>  29
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Synthetic: 26874-29_57


<220>
<221>  misc_feature
<222>  (1)..(29)
<223>  Every n is a C-5 modified pyrimidine such as TyrdU, NapdC, ThdU, 
       O, MOEdU, 2NapdU, BTdU, POPdU, 2NEdU, iBudU, MBndU, BPEdU, FBndU,
       NapdU, TrpdU, BndU, PBndU, NEdU, PEdU, BFdU, or PPdU

<220>
<221>  misc_feature
<222>  (1)..(29)
<223>  See specification as filed for detailed description of 
       substitutions and preferred embodiments

<400>  39
ggganannan gngnnngann gnnnggang                                         29


<210>  40
<211>  29
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Synthetic: 26874-29_58


<220>
<221>  misc_feature
<222>  (1)..(29)
<223>  Every n is a C-5 modified pyrimidine such as TyrdU, NapdC, ThdU, 
       O, MOEdU, 2NapdU, BTdU, POPdU, 2NEdU, iBudU, MBndU, BPEdU, FBndU,
       NapdU, TrpdU, BndU, PBndU, NEdU, PEdU, BFdU, or PPdU

<220>
<221>  misc_feature
<222>  (1)..(29)
<223>  See specification as filed for detailed description of 
       substitutions and preferred embodiments

<400>  40
ggganannan gngnnngann gnnnggang                                         29


<210>  41
<211>  29
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Synthetic: 26874-29_59


<220>
<221>  misc_feature
<222>  (1)..(29)
<223>  Every n is a C-5 modified pyrimidine such as TyrdU, NapdC, ThdU, 
       O, MOEdU, 2NapdU, BTdU, POPdU, 2NEdU, iBudU, MBndU, BPEdU, FBndU,
       NapdU, TrpdU, BndU, PBndU, NEdU, PEdU, BFdU, or PPdU

<220>
<221>  misc_feature
<222>  (1)..(29)
<223>  See specification as filed for detailed description of 
       substitutions and preferred embodiments

<400>  41
ggganannan gngnnngann gnnnggang                                         29


<210>  42
<211>  29
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Synthetic: 26874-29_60


<220>
<221>  misc_feature
<222>  (1)..(29)
<223>  Every n is a C-5 modified pyrimidine such as TyrdU, NapdC, ThdU, 
       O, MOEdU, 2NapdU, BTdU, POPdU, 2NEdU, iBudU, MBndU, BPEdU, FBndU,
       NapdU, TrpdU, BndU, PBndU, NEdU, PEdU, BFdU, or PPdU

<220>
<221>  misc_feature
<222>  (1)..(29)
<223>  See specification as filed for detailed description of 
       substitutions and preferred embodiments

<400>  42
ggganannan gngnnngann gnnnggang                                         29


<210>  43
<211>  29
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Synthetic: 26874-29_61


<220>
<221>  misc_feature
<222>  (1)..(29)
<223>  Every n is a C-5 modified pyrimidine such as TyrdU, NapdC, ThdU, 
       O, MOEdU, 2NapdU, BTdU, POPdU, 2NEdU, iBudU, MBndU, BPEdU, FBndU,
       NapdU, TrpdU, BndU, PBndU, NEdU, PEdU, BFdU, or PPdU

<220>
<221>  misc_feature
<222>  (1)..(29)
<223>  See specification as filed for detailed description of 
       substitutions and preferred embodiments

<400>  43
ggganannan gngnnngann gnnnggang                                         29


<210>  44
<211>  29
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Synthetic: 26874-29_62


<220>
<221>  misc_feature
<222>  (1)..(29)
<223>  Every n is a C-5 modified pyrimidine such as TyrdU, NapdC, ThdU, 
       O, MOEdU, 2NapdU, BTdU, POPdU, 2NEdU, iBudU, MBndU, BPEdU, FBndU,
       NapdU, TrpdU, BndU, PBndU, NEdU, PEdU, BFdU, or PPdU

<220>
<221>  misc_feature
<222>  (1)..(29)
<223>  See specification as filed for detailed description of 
       substitutions and preferred embodiments

<400>  44
ggganannan gngnnngann gnnnggang                                         29


<210>  45
<211>  29
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Synthetic: 26874-29_63


<220>
<221>  misc_feature
<222>  (1)..(29)
<223>  Every n is a C-5 modified pyrimidine such as TyrdU, NapdC, ThdU, 
       O, MOEdU, 2NapdU, BTdU, POPdU, 2NEdU, iBudU, MBndU, BPEdU, FBndU,
       NapdU, TrpdU, BndU, PBndU, NEdU, PEdU, BFdU, or PPdU

<220>
<221>  misc_feature
<222>  (1)..(29)
<223>  See specification as filed for detailed description of 
       substitutions and preferred embodiments

<400>  45
ggganannan gngnnngann gnnnggang                                         29


<210>  46
<211>  29
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Synthetic: 26874-29_64


<220>
<221>  misc_feature
<222>  (1)..(29)
<223>  Every n is a C-5 modified pyrimidine such as TyrdU, NapdC, ThdU, 
       O, MOEdU, 2NapdU, BTdU, POPdU, 2NEdU, iBudU, MBndU, BPEdU, FBndU,
       NapdU, TrpdU, BndU, PBndU, NEdU, PEdU, BFdU, or PPdU

<220>
<221>  misc_feature
<222>  (1)..(29)
<223>  See specification as filed for detailed description of 
       substitutions and preferred embodiments

<400>  46
ggganannan gngnnngann gnnnggang                                         29


<210>  47
<211>  29
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Synthetic: 26874-29_65


<220>
<221>  misc_feature
<222>  (1)..(29)
<223>  Every n is a C-5 modified pyrimidine such as TyrdU, NapdC, ThdU, 
       O, MOEdU, 2NapdU, BTdU, POPdU, 2NEdU, iBudU, MBndU, BPEdU, FBndU,
       NapdU, TrpdU, BndU, PBndU, NEdU, PEdU, BFdU, or PPdU

<220>
<221>  misc_feature
<222>  (1)..(29)
<223>  See specification as filed for detailed description of 
       substitutions and preferred embodiments

<400>  47
ggganannan gngnnngann gnnnggang                                         29


<210>  48
<211>  29
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Synthetic: 26874-29_66


<220>
<221>  misc_feature
<222>  (1)..(29)
<223>  Every n is a C-5 modified pyrimidine such as TyrdU, NapdC, ThdU, 
       O, MOEdU, 2NapdU, BTdU, POPdU, 2NEdU, iBudU, MBndU, BPEdU, FBndU,
       NapdU, TrpdU, BndU, PBndU, NEdU, PEdU, BFdU, or PPdU

<220>
<221>  misc_feature
<222>  (1)..(29)
<223>  See specification as filed for detailed description of 
       substitutions and preferred embodiments

<400>  48
ggganannan gngnnngann gnnnggang                                         29


<210>  49
<211>  29
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Synthetic: 26874-29_68


<220>
<221>  misc_feature
<222>  (1)..(29)
<223>  Every n is a C-5 modified pyrimidine such as TyrdU, NapdC, ThdU, 
       O, MOEdU, 2NapdU, BTdU, POPdU, 2NEdU, iBudU, MBndU, BPEdU, FBndU,
       NapdU, TrpdU, BndU, PBndU, NEdU, PEdU, BFdU, or PPdU

<220>
<221>  misc_feature
<222>  (1)..(29)
<223>  See specification as filed for detailed description of 
       substitutions and preferred embodiments

<400>  49
ggganannan gngnnngann gnnnggang                                         29


<210>  50
<211>  29
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Synthetic: 26874-29_70


<220>
<221>  misc_feature
<222>  (1)..(29)
<223>  Every n is a C-5 modified pyrimidine such as TyrdU, NapdC, ThdU, 
       O, MOEdU, 2NapdU, BTdU, POPdU, 2NEdU, iBudU, MBndU, BPEdU, FBndU,
       NapdU, TrpdU, BndU, PBndU, NEdU, PEdU, BFdU, or PPdU

<220>
<221>  misc_feature
<222>  (1)..(29)
<223>  See specification as filed for detailed description of 
       substitutions and preferred embodiments

<400>  50
ggganannan gngnnngann gnnnggang                                         29


<210>  51
<211>  29
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Synthetic: 26874-29_72


<220>
<221>  misc_feature
<222>  (1)..(29)
<223>  Every n is a C-5 modified pyrimidine such as TyrdU, NapdC, ThdU, 
       O, MOEdU, 2NapdU, BTdU, POPdU, 2NEdU, iBudU, MBndU, BPEdU, FBndU,
       NapdU, TrpdU, BndU, PBndU, NEdU, PEdU, BFdU, or PPdU

<220>
<221>  misc_feature
<222>  (1)..(29)
<223>  See specification as filed for detailed description of 
       substitutions and preferred embodiments

<400>  51
ggganannan gngnnngann gnnnggang                                         29


<210>  52
<211>  29
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Synthetic: 26874-29_74


<220>
<221>  misc_feature
<222>  (1)..(29)
<223>  Every n is a C-5 modified pyrimidine such as TyrdU, NapdC, ThdU, 
       O, MOEdU, 2NapdU, BTdU, POPdU, 2NEdU, iBudU, MBndU, BPEdU, FBndU,
       NapdU, TrpdU, BndU, PBndU, NEdU, PEdU, BFdU, or PPdU

<220>
<221>  misc_feature
<222>  (1)..(29)
<223>  See specification as filed for detailed description of 
       substitutions and preferred embodiments

<400>  52
ggganannan gngnnngann gnnnggang                                         29


<210>  53
<211>  29
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Synthetic: 26874-29_76


<220>
<221>  misc_feature
<222>  (1)..(29)
<223>  Every n is a C-5 modified pyrimidine such as TyrdU, NapdC, ThdU, 
       O, MOEdU, 2NapdU, BTdU, POPdU, 2NEdU, iBudU, MBndU, BPEdU, FBndU,
       NapdU, TrpdU, BndU, PBndU, NEdU, PEdU, BFdU, or PPdU

<220>
<221>  misc_feature
<222>  (1)..(29)
<223>  See specification as filed for detailed description of 
       substitutions and preferred embodiments

<400>  53
ggganannan gngnnngann gnnnggang                                         29


<210>  54
<211>  29
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Synthetic: 26874-29_77


<220>
<221>  misc_feature
<222>  (1)..(29)
<223>  Every n is a C-5 modified pyrimidine such as TyrdU, NapdC, ThdU, 
       O, MOEdU, 2NapdU, BTdU, POPdU, 2NEdU, iBudU, MBndU, BPEdU, FBndU,
       NapdU, TrpdU, BndU, PBndU, NEdU, PEdU, BFdU, or PPdU

<220>
<221>  misc_feature
<222>  (1)..(29)
<223>  See specification as filed for detailed description of 
       substitutions and preferred embodiments

<400>  54
ggganannan gngnnngann gnnnggang                                         29


<210>  55
<211>  29
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Synthetic: 26874-29_78


<220>
<221>  misc_feature
<222>  (1)..(29)
<223>  Every n is a C-5 modified pyrimidine such as TyrdU, NapdC, ThdU, 
       O, MOEdU, 2NapdU, BTdU, POPdU, 2NEdU, iBudU, MBndU, BPEdU, FBndU,
       NapdU, TrpdU, BndU, PBndU, NEdU, PEdU, BFdU, or PPdU

<220>
<221>  misc_feature
<222>  (1)..(29)
<223>  See specification as filed for detailed description of 
       substitutions and preferred embodiments

<400>  55
ggganannan gngnnngann gnnnggang                                         29


<210>  56
<211>  29
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Synthetic: 26874-29_79


<220>
<221>  misc_feature
<222>  (1)..(29)
<223>  Every n is a C-5 modified pyrimidine such as TyrdU, NapdC, ThdU, 
       O, MOEdU, 2NapdU, BTdU, POPdU, 2NEdU, iBudU, MBndU, BPEdU, FBndU,
       NapdU, TrpdU, BndU, PBndU, NEdU, PEdU, BFdU, or PPdU

<220>
<221>  misc_feature
<222>  (1)..(29)
<223>  See specification as filed for detailed description of 
       substitutions and preferred embodiments

<400>  56
ggganannan gngnnngann gnnnggang                                         29


<210>  57
<211>  29
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Synthetic: 26874-29_80


<220>
<221>  misc_feature
<222>  (1)..(29)
<223>  Every n is a C-5 modified pyrimidine such as TyrdU, NapdC, ThdU, 
       O, MOEdU, 2NapdU, BTdU, POPdU, 2NEdU, iBudU, MBndU, BPEdU, FBndU,
       NapdU, TrpdU, BndU, PBndU, NEdU, PEdU, BFdU, or PPdU

<220>
<221>  misc_feature
<222>  (1)..(29)
<223>  See specification as filed for detailed description of 
       substitutions and preferred embodiments

<400>  57
ggganannan gngnnngann gnnnggang                                         29


<210>  58
<211>  29
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Synthetic: 26874-29_81


<220>
<221>  misc_feature
<222>  (1)..(29)
<223>  Every n is a C-5 modified pyrimidine such as TyrdU, NapdC, ThdU, 
       O, MOEdU, 2NapdU, BTdU, POPdU, 2NEdU, iBudU, MBndU, BPEdU, FBndU,
       NapdU, TrpdU, BndU, PBndU, NEdU, PEdU, BFdU, or PPdU

<220>
<221>  misc_feature
<222>  (1)..(29)
<223>  See specification as filed for detailed description of 
       substitutions and preferred embodiments

<400>  58
ggganannan gngnnngann gnnnggang                                         29


<210>  59
<211>  29
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Synthetic: 26874-29_82


<220>
<221>  misc_feature
<222>  (1)..(29)
<223>  Every n is a C-5 modified pyrimidine such as TyrdU, NapdC, ThdU, 
       O, MOEdU, 2NapdU, BTdU, POPdU, 2NEdU, iBudU, MBndU, BPEdU, FBndU,
       NapdU, TrpdU, BndU, PBndU, NEdU, PEdU, BFdU, or PPdU

<220>
<221>  misc_feature
<222>  (1)..(29)
<223>  See specification as filed for detailed description of 
       substitutions and preferred embodiments

<400>  59
ggganannan gngnnngann gnnnggang                                         29


<210>  60
<211>  29
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Synthetic: 26874-29_83


<220>
<221>  misc_feature
<222>  (1)..(29)
<223>  Every n is a C-5 modified pyrimidine such as TyrdU, NapdC, ThdU, 
       O, MOEdU, 2NapdU, BTdU, POPdU, 2NEdU, iBudU, MBndU, BPEdU, FBndU,
       NapdU, TrpdU, BndU, PBndU, NEdU, PEdU, BFdU, or PPdU

<220>
<221>  misc_feature
<222>  (1)..(29)
<223>  See specification as filed for detailed description of 
       substitutions and preferred embodiments

<400>  60
ggganannan gngnnngann gnnnggang                                         29


<210>  61
<211>  29
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Synthetic: 26874-29_84


<220>
<221>  misc_feature
<222>  (1)..(29)
<223>  Every n is a C-5 modified pyrimidine such as TyrdU, NapdC, ThdU, 
       O, MOEdU, 2NapdU, BTdU, POPdU, 2NEdU, iBudU, MBndU, BPEdU, FBndU,
       NapdU, TrpdU, BndU, PBndU, NEdU, PEdU, BFdU, or PPdU

<220>
<221>  misc_feature
<222>  (1)..(29)
<223>  See specification as filed for detailed description of 
       substitutions and preferred embodiments

<400>  61
ggganannan gngnnngann gnnnggang                                         29


<210>  62
<211>  29
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Synthetic: 26874-29_85


<220>
<221>  misc_feature
<222>  (1)..(29)
<223>  Every n is a C-5 modified pyrimidine such as TyrdU, NapdC, ThdU, 
       O, MOEdU, 2NapdU, BTdU, POPdU, 2NEdU, iBudU, MBndU, BPEdU, FBndU,
       NapdU, TrpdU, BndU, PBndU, NEdU, PEdU, BFdU, or PPdU

<220>
<221>  misc_feature
<222>  (1)..(29)
<223>  See specification as filed for detailed description of 
       substitutions and preferred embodiments

<400>  62
ggganannan gngnnngann gnnnggang                                         29


<210>  63
<211>  29
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Synthetic: 26874-29_86


<220>
<221>  misc_feature
<222>  (1)..(29)
<223>  Every n is a C-5 modified pyrimidine such as TyrdU, NapdC, ThdU, 
       O, MOEdU, 2NapdU, BTdU, POPdU, 2NEdU, iBudU, MBndU, BPEdU, FBndU,
       NapdU, TrpdU, BndU, PBndU, NEdU, PEdU, BFdU, or PPdU

<220>
<221>  misc_feature
<222>  (1)..(29)
<223>  See specification as filed for detailed description of 
       substitutions and preferred embodiments

<400>  63
ggganannan gngnnngann gnnnggang                                         29


<210>  64
<211>  29
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Synthetic: 26874-29_87


<220>
<221>  misc_feature
<222>  (1)..(29)
<223>  Every n is a C-5 modified pyrimidine such as TyrdU, NapdC, ThdU, 
       O, MOEdU, 2NapdU, BTdU, POPdU, 2NEdU, iBudU, MBndU, BPEdU, FBndU,
       NapdU, TrpdU, BndU, PBndU, NEdU, PEdU, BFdU, or PPdU

<220>
<221>  misc_feature
<222>  (1)..(29)
<223>  See specification as filed for detailed description of 
       substitutions and preferred embodiments

<400>  64
ggganannan gngnnngann gnnnggang                                         29


<210>  65
<211>  29
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Synthetic: 26874-29_88


<220>
<221>  misc_feature
<222>  (1)..(29)
<223>  Every n is a C-5 modified pyrimidine such as TyrdU, NapdC, ThdU, 
       O, MOEdU, 2NapdU, BTdU, POPdU, 2NEdU, iBudU, MBndU, BPEdU, FBndU,
       NapdU, TrpdU, BndU, PBndU, NEdU, PEdU, BFdU, or PPdU

<220>
<221>  misc_feature
<222>  (1)..(29)
<223>  See specification as filed for detailed description of 
       substitutions and preferred embodiments

<400>  65
ggganannan gngnnngann gnnnggang                                         29


<210>  66
<211>  29
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Synthetic: 26874-29_89


<220>
<221>  misc_feature
<222>  (1)..(29)
<223>  Every n is a C-5 modified pyrimidine such as TyrdU, NapdC, ThdU, 
       O, MOEdU, 2NapdU, BTdU, POPdU, 2NEdU, iBudU, MBndU, BPEdU, FBndU,
       NapdU, TrpdU, BndU, PBndU, NEdU, PEdU, BFdU, or PPdU

<220>
<221>  misc_feature
<222>  (1)..(29)
<223>  See specification as filed for detailed description of 
       substitutions and preferred embodiments

<400>  66
ggganannan gngnnngann gnnnggang                                         29


<210>  67
<211>  29
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Synthetic: 26874-29_90


<220>
<221>  misc_feature
<222>  (1)..(29)
<223>  Every n is a C-5 modified pyrimidine such as TyrdU, NapdC, ThdU, 
       O, MOEdU, 2NapdU, BTdU, POPdU, 2NEdU, iBudU, MBndU, BPEdU, FBndU,
       NapdU, TrpdU, BndU, PBndU, NEdU, PEdU, BFdU, or PPdU

<220>
<221>  misc_feature
<222>  (1)..(29)
<223>  See specification as filed for detailed description of 
       substitutions and preferred embodiments

<400>  67
ggganannan gngnnngann gnnnggang                                         29


<210>  68
<211>  29
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Synthetic: 26874-29_91


<220>
<221>  misc_feature
<222>  (1)..(29)
<223>  Every n is a C-5 modified pyrimidine such as TyrdU, NapdC, ThdU, 
       O, MOEdU, 2NapdU, BTdU, POPdU, 2NEdU, iBudU, MBndU, BPEdU, FBndU,
       NapdU, TrpdU, BndU, PBndU, NEdU, PEdU, BFdU, or PPdU

<220>
<221>  misc_feature
<222>  (1)..(29)
<223>  See specification as filed for detailed description of 
       substitutions and preferred embodiments

<400>  68
ggganannan gngnnngann gnnnggang                                         29


<210>  69
<211>  29
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Synthetic: 26874-29_92


<220>
<221>  misc_feature
<222>  (1)..(29)
<223>  Every n is a C-5 modified pyrimidine such as TyrdU, NapdC, ThdU, 
       O, MOEdU, 2NapdU, BTdU, POPdU, 2NEdU, iBudU, MBndU, BPEdU, FBndU,
       NapdU, TrpdU, BndU, PBndU, NEdU, PEdU, BFdU, or PPdU

<220>
<221>  misc_feature
<222>  (1)..(29)
<223>  See specification as filed for detailed description of 
       substitutions and preferred embodiments

<400>  69
ggganannan gngnnngann gnnnggang                                         29


<210>  70
<211>  29
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Synthetic: 26874-29_93


<220>
<221>  misc_feature
<222>  (1)..(29)
<223>  Every n is a C-5 modified pyrimidine such as TyrdU, NapdC, ThdU, 
       O, MOEdU, 2NapdU, BTdU, POPdU, 2NEdU, iBudU, MBndU, BPEdU, FBndU,
       NapdU, TrpdU, BndU, PBndU, NEdU, PEdU, BFdU, or PPdU

<220>
<221>  misc_feature
<222>  (1)..(29)
<223>  See specification as filed for detailed description of 
       substitutions and preferred embodiments

<400>  70
ggganannan gngnnngann gnnnggang                                         29


<210>  71
<211>  29
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Synthetic: 26874-29_94


<220>
<221>  misc_feature
<222>  (1)..(29)
<223>  Every n is a C-5 modified pyrimidine such as TyrdU, NapdC, ThdU, 
       O, MOEdU, 2NapdU, BTdU, POPdU, 2NEdU, iBudU, MBndU, BPEdU, FBndU,
       NapdU, TrpdU, BndU, PBndU, NEdU, PEdU, BFdU, or PPdU

<220>
<221>  misc_feature
<222>  (1)..(29)
<223>  See specification as filed for detailed description of 
       substitutions and preferred embodiments

<400>  71
ggganannan gngnnngann gnnnggang                                         29


<210>  72
<211>  29
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Synthetic: 26874-29_95


<220>
<221>  misc_feature
<222>  (1)..(29)
<223>  Every n is a C-5 modified pyrimidine such as TyrdU, NapdC, ThdU, 
       O, MOEdU, 2NapdU, BTdU, POPdU, 2NEdU, iBudU, MBndU, BPEdU, FBndU,
       NapdU, TrpdU, BndU, PBndU, NEdU, PEdU, BFdU, or PPdU

<220>
<221>  misc_feature
<222>  (1)..(29)
<223>  See specification as filed for detailed description of 
       substitutions and preferred embodiments

<400>  72
ggganannan gngnnngann gnnnggang                                         29


<210>  73
<211>  29
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Synthetic: 26874-29_96


<220>
<221>  misc_feature
<222>  (1)..(29)
<223>  Every n is a C-5 modified pyrimidine such as TyrdU, NapdC, ThdU, 
       O, MOEdU, 2NapdU, BTdU, POPdU, 2NEdU, iBudU, MBndU, BPEdU, FBndU,
       NapdU, TrpdU, BndU, PBndU, NEdU, PEdU, BFdU, or PPdU

<220>
<221>  misc_feature
<222>  (1)..(29)
<223>  See specification as filed for detailed description of 
       substitutions and preferred embodiments

<400>  73
gggahannan gngnnngann gnnnggang                                         29


<210>  74
<211>  29
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Synthetic: 26874-29_97


<220>
<221>  misc_feature
<222>  (1)..(29)
<223>  Every n is a C-5 modified pyrimidine such as TyrdU, NapdC, ThdU, 
       O, MOEdU, 2NapdU, BTdU, POPdU, 2NEdU, iBudU, MBndU, BPEdU, FBndU,
       NapdU, TrpdU, BndU, PBndU, NEdU, PEdU, BFdU, or PPdU

<220>
<221>  misc_feature
<222>  (1)..(29)
<223>  See specification as filed for detailed description of 
       substitutions and preferred embodiments

<400>  74
ggganannan gngnnngann gnnnggang                                         29


<210>  75
<211>  29
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Synthetic: 26874-29_98


<220>
<221>  misc_feature
<222>  (1)..(29)
<223>  Every n is a C-5 modified pyrimidine such as TyrdU, NapdC, ThdU, 
       O, MOEdU, 2NapdU, BTdU, POPdU, 2NEdU, iBudU, MBndU, BPEdU, FBndU,
       NapdU, TrpdU, BndU, PBndU, NEdU, PEdU, BFdU, or PPdU

<220>
<221>  misc_feature
<222>  (1)..(29)
<223>  See specification as filed for detailed description of 
       substitutions and preferred embodiments

<400>  75
gggananhan gngnnngann gnnnggang                                         29


<210>  76
<211>  29
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Synthetic: 26874-29_99


<220>
<221>  misc_feature
<222>  (1)..(29)
<223>  Every n is a C-5 modified pyrimidine such as TyrdU, NapdC, ThdU, 
       O, MOEdU, 2NapdU, BTdU, POPdU, 2NEdU, iBudU, MBndU, BPEdU, FBndU,
       NapdU, TrpdU, BndU, PBndU, NEdU, PEdU, BFdU, or PPdU

<220>
<221>  misc_feature
<222>  (1)..(29)
<223>  See specification as filed for detailed description of 
       substitutions and preferred embodiments

<400>  76
ggganannan gngnnngann gnnnggang                                         29


<210>  77
<211>  29
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Synthetic: 26874-29_100


<220>
<221>  misc_feature
<222>  (1)..(29)
<223>  Every n is a C-5 modified pyrimidine such as TyrdU, NapdC, ThdU, 
       O, MOEdU, 2NapdU, BTdU, POPdU, 2NEdU, iBudU, MBndU, BPEdU, FBndU,
       NapdU, TrpdU, BndU, PBndU, NEdU, PEdU, BFdU, or PPdU

<220>
<221>  misc_feature
<222>  (1)..(29)
<223>  See specification as filed for detailed description of 
       substitutions and preferred embodiments

<400>  77
ggganannan gnghnngann gnnnggang                                         29


<210>  78
<211>  29
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Synthetic: 26874-29_101


<220>
<221>  misc_feature
<222>  (1)..(29)
<223>  Every n is a C-5 modified pyrimidine such as TyrdU, NapdC, ThdU, 
       O, MOEdU, 2NapdU, BTdU, POPdU, 2NEdU, iBudU, MBndU, BPEdU, FBndU,
       NapdU, TrpdU, BndU, PBndU, NEdU, PEdU, BFdU, or PPdU

<220>
<221>  misc_feature
<222>  (1)..(29)
<223>  See specification as filed for detailed description of 
       substitutions and preferred embodiments

<400>  78
ggganannan gngnnngann gnnnggang                                         29


<210>  79
<211>  29
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Synthetic: 26874-29_102


<220>
<221>  misc_feature
<222>  (1)..(29)
<223>  Every n is a C-5 modified pyrimidine such as TyrdU, NapdC, ThdU, 
       O, MOEdU, 2NapdU, BTdU, POPdU, 2NEdU, iBudU, MBndU, BPEdU, FBndU,
       NapdU, TrpdU, BndU, PBndU, NEdU, PEdU, BFdU, or PPdU

<220>
<221>  misc_feature
<222>  (1)..(29)
<223>  See specification as filed for detailed description of 
       substitutions and preferred embodiments

<400>  79
ggganannan gnghnngann gnnnggang                                         29


<210>  80
<211>  29
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Synthetic: 26874-29_103


<220>
<221>  misc_feature
<222>  (1)..(29)
<223>  Every n is a C-5 modified pyrimidine such as TyrdU, NapdC, ThdU, 
       O, MOEdU, 2NapdU, BTdU, POPdU, 2NEdU, iBudU, MBndU, BPEdU, FBndU,
       NapdU, TrpdU, BndU, PBndU, NEdU, PEdU, BFdU, or PPdU

<220>
<221>  misc_feature
<222>  (1)..(29)
<223>  See specification as filed for detailed description of 
       substitutions and preferred embodiments

<400>  80
ggganannan gngnnngann gnnnggang                                         29


<210>  81
<211>  29
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Synthetic: 26874-29_104


<220>
<221>  misc_feature
<222>  (1)..(29)
<223>  Every n is a C-5 modified pyrimidine such as TyrdU, NapdC, ThdU, 
       O, MOEdU, 2NapdU, BTdU, POPdU, 2NEdU, iBudU, MBndU, BPEdU, FBndU,
       NapdU, TrpdU, BndU, PBndU, NEdU, PEdU, BFdU, or PPdU

<220>
<221>  misc_feature
<222>  (1)..(29)
<223>  See specification as filed for detailed description of 
       substitutions and preferred embodiments

<400>  81
ggganannan gngnnngann gnhnggang                                         29


<210>  82
<211>  29
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Synthetic: 26874-29_105


<220>
<221>  misc_feature
<222>  (1)..(29)
<223>  Every n is a C-5 modified pyrimidine such as TyrdU, NapdC, ThdU, 
       O, MOEdU, 2NapdU, BTdU, POPdU, 2NEdU, iBudU, MBndU, BPEdU, FBndU,
       NapdU, TrpdU, BndU, PBndU, NEdU, PEdU, BFdU, or PPdU

<220>
<221>  misc_feature
<222>  (1)..(29)
<223>  See specification as filed for detailed description of 
       substitutions and preferred embodiments

<400>  82
ggganannan gngnnngann gnnnggang                                         29


<210>  83
<211>  29
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Synthetic: 26874-29_106


<220>
<221>  misc_feature
<222>  (1)..(29)
<223>  Every n is a C-5 modified pyrimidine such as TyrdU, NapdC, ThdU, 
       O, MOEdU, 2NapdU, BTdU, POPdU, 2NEdU, iBudU, MBndU, BPEdU, FBndU,
       NapdU, TrpdU, BndU, PBndU, NEdU, PEdU, BFdU, or PPdU

<220>
<221>  misc_feature
<222>  (1)..(29)
<223>  See specification as filed for detailed description of 
       substitutions and preferred embodiments

<400>  83
ggganannan gngnnngann gnnnggang                                         29


<210>  84
<211>  29
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Synthetic: 26874-29_107


<220>
<221>  misc_feature
<222>  (1)..(29)
<223>  Every n is a C-5 modified pyrimidine such as TyrdU, NapdC, ThdU, 
       O, MOEdU, 2NapdU, BTdU, POPdU, 2NEdU, iBudU, MBndU, BPEdU, FBndU,
       NapdU, TrpdU, BndU, PBndU, NEdU, PEdU, BFdU, or PPdU

<220>
<221>  misc_feature
<222>  (1)..(29)
<223>  See specification as filed for detailed description of 
       substitutions and preferred embodiments

<400>  84
ggganannan gngnnngann gnnnggang                                         29


<210>  85
<211>  29
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Synthetic: 26874-29_108


<220>
<221>  misc_feature
<222>  (1)..(29)
<223>  Every n is a C-5 modified pyrimidine such as TyrdU, NapdC, ThdU, 
       O, MOEdU, 2NapdU, BTdU, POPdU, 2NEdU, iBudU, MBndU, BPEdU, FBndU,
       NapdU, TrpdU, BndU, PBndU, NEdU, PEdU, BFdU, or PPdU

<220>
<221>  misc_feature
<222>  (1)..(29)
<223>  See specification as filed for detailed description of 
       substitutions and preferred embodiments

<400>  85
ggganannan gngnnngann gnnnggang                                         29


<210>  86
<211>  29
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Synthetic: 26874-29_109


<220>
<221>  misc_feature
<222>  (1)..(29)
<223>  Every n is a C-5 modified pyrimidine such as TyrdU, NapdC, ThdU, 
       O, MOEdU, 2NapdU, BTdU, POPdU, 2NEdU, iBudU, MBndU, BPEdU, FBndU,
       NapdU, TrpdU, BndU, PBndU, NEdU, PEdU, BFdU, or PPdU

<220>
<221>  misc_feature
<222>  (1)..(29)
<223>  See specification as filed for detailed description of 
       substitutions and preferred embodiments

<400>  86
ggganannan gngnnngann gnnnggang                                         29


<210>  87
<211>  29
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Synthetic: 26874-29_110


<220>
<221>  misc_feature
<222>  (1)..(29)
<223>  Every n is a C-5 modified pyrimidine such as TyrdU, NapdC, ThdU, 
       O, MOEdU, 2NapdU, BTdU, POPdU, 2NEdU, iBudU, MBndU, BPEdU, FBndU,
       NapdU, TrpdU, BndU, PBndU, NEdU, PEdU, BFdU, or PPdU

<220>
<221>  misc_feature
<222>  (1)..(29)
<223>  See specification as filed for detailed description of 
       substitutions and preferred embodiments

<400>  87
ggganannan gngnnngann gnnnggang                                         29


<210>  88
<211>  29
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Synthetic: 26874-29_112


<220>
<221>  misc_feature
<222>  (1)..(29)
<223>  Every n is a C-5 modified pyrimidine such as TyrdU, NapdC, ThdU, 
       O, MOEdU, 2NapdU, BTdU, POPdU, 2NEdU, iBudU, MBndU, BPEdU, FBndU,
       NapdU, TrpdU, BndU, PBndU, NEdU, PEdU, BFdU, or PPdU

<220>
<221>  misc_feature
<222>  (1)..(29)
<223>  See specification as filed for detailed description of 
       substitutions and preferred embodiments

<400>  88
ggganannan gngnnngann gnnnggang                                         29


<210>  89
<211>  29
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Synthetic: 26874-29_113


<220>
<221>  misc_feature
<222>  (1)..(29)
<223>  Every n is a C-5 modified pyrimidine such as TyrdU, NapdC, ThdU, 
       O, MOEdU, 2NapdU, BTdU, POPdU, 2NEdU, iBudU, MBndU, BPEdU, FBndU,
       NapdU, TrpdU, BndU, PBndU, NEdU, PEdU, BFdU, or PPdU

<220>
<221>  misc_feature
<222>  (1)..(29)
<223>  See specification as filed for detailed description of 
       substitutions and preferred embodiments

<400>  89
ggganannan gngnnngann gnnnggang                                         29


<210>  90
<211>  29
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Synthetic: 26874-29_114


<220>
<221>  misc_feature
<222>  (1)..(29)
<223>  Every n is a C-5 modified pyrimidine such as TyrdU, NapdC, ThdU, 
       O, MOEdU, 2NapdU, BTdU, POPdU, 2NEdU, iBudU, MBndU, BPEdU, FBndU,
       NapdU, TrpdU, BndU, PBndU, NEdU, PEdU, BFdU, or PPdU

<220>
<221>  misc_feature
<222>  (1)..(29)
<223>  See specification as filed for detailed description of 
       substitutions and preferred embodiments

<400>  90
ggganannan gngnnngann gnnnggang                                         29


<210>  91
<211>  29
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Synthetic: 26874-29_115


<220>
<221>  misc_feature
<222>  (1)..(29)
<223>  Every n is a C-5 modified pyrimidine such as TyrdU, NapdC, ThdU, 
       O, MOEdU, 2NapdU, BTdU, POPdU, 2NEdU, iBudU, MBndU, BPEdU, FBndU,
       NapdU, TrpdU, BndU, PBndU, NEdU, PEdU, BFdU, or PPdU

<220>
<221>  misc_feature
<222>  (1)..(29)
<223>  See specification as filed for detailed description of 
       substitutions and preferred embodiments

<400>  91
ggganannan gngnnngann gnnnggang                                         29


<210>  92
<211>  29
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Synthetic: 26874-29_116


<220>
<221>  misc_feature
<222>  (1)..(29)
<223>  Every n is a C-5 modified pyrimidine such as TyrdU, NapdC, ThdU, 
       O, MOEdU, 2NapdU, BTdU, POPdU, 2NEdU, iBudU, MBndU, BPEdU, FBndU,
       NapdU, TrpdU, BndU, PBndU, NEdU, PEdU, BFdU, or PPdU

<220>
<221>  misc_feature
<222>  (1)..(29)
<223>  See specification as filed for detailed description of 
       substitutions and preferred embodiments

<400>  92
ggganannan gngnnngann gnnnggang                                         29


<210>  93
<211>  29
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Synthetic: 26874-29_117


<220>
<221>  misc_feature
<222>  (1)..(29)
<223>  Every n is a C-5 modified pyrimidine such as TyrdU, NapdC, ThdU, 
       O, MOEdU, 2NapdU, BTdU, POPdU, 2NEdU, iBudU, MBndU, BPEdU, FBndU,
       NapdU, TrpdU, BndU, PBndU, NEdU, PEdU, BFdU, or PPdU

<220>
<221>  misc_feature
<222>  (1)..(29)
<223>  See specification as filed for detailed description of 
       substitutions and preferred embodiments

<400>  93
ggganannan gngnnngann gnnnggang                                         29


<210>  94
<211>  29
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Synthetic: 26874-29_118


<220>
<221>  misc_feature
<222>  (1)..(29)
<223>  Every n is a C-5 modified pyrimidine such as TyrdU, NapdC, ThdU, 
       O, MOEdU, 2NapdU, BTdU, POPdU, 2NEdU, iBudU, MBndU, BPEdU, FBndU,
       NapdU, TrpdU, BndU, PBndU, NEdU, PEdU, BFdU, or PPdU

<220>
<221>  misc_feature
<222>  (1)..(29)
<223>  See specification as filed for detailed description of 
       substitutions and preferred embodiments

<400>  94
ggganannan gngnnngann gnnnggang                                         29


<210>  95
<211>  29
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Synthetic: 26874-29_119


<220>
<221>  misc_feature
<222>  (1)..(29)
<223>  Every n is a C-5 modified pyrimidine such as TyrdU, NapdC, ThdU, 
       O, MOEdU, 2NapdU, BTdU, POPdU, 2NEdU, iBudU, MBndU, BPEdU, FBndU,
       NapdU, TrpdU, BndU, PBndU, NEdU, PEdU, BFdU, or PPdU

<220>
<221>  misc_feature
<222>  (1)..(29)
<223>  See specification as filed for detailed description of 
       substitutions and preferred embodiments

<400>  95
ggganannan gngnnngann gnnnggang                                         29


<210>  96
<211>  29
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Synthetic: 26874-29_120


<220>
<221>  misc_feature
<222>  (1)..(29)
<223>  Every n is a C-5 modified pyrimidine such as TyrdU, NapdC, ThdU, 
       O, MOEdU, 2NapdU, BTdU, POPdU, 2NEdU, iBudU, MBndU, BPEdU, FBndU,
       NapdU, TrpdU, BndU, PBndU, NEdU, PEdU, BFdU, or PPdU

<220>
<221>  misc_feature
<222>  (1)..(29)
<223>  See specification as filed for detailed description of 
       substitutions and preferred embodiments

<400>  96
ggganannan gngnnngann gnnnggang                                         29


<210>  97
<211>  29
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Synthetic: 26874-29_121


<220>
<221>  misc_feature
<222>  (1)..(29)
<223>  Every n is a C-5 modified pyrimidine such as TyrdU, NapdC, ThdU, 
       O, MOEdU, 2NapdU, BTdU, POPdU, 2NEdU, iBudU, MBndU, BPEdU, FBndU,
       NapdU, TrpdU, BndU, PBndU, NEdU, PEdU, BFdU, or PPdU

<220>
<221>  misc_feature
<222>  (1)..(29)
<223>  See specification as filed for detailed description of 
       substitutions and preferred embodiments

<400>  97
ggganannan gngnnngann gnnnggang                                         29


<210>  98
<211>  29
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Synthetic: 26874-29_122


<220>
<221>  misc_feature
<222>  (1)..(29)
<223>  Every n is a C-5 modified pyrimidine such as TyrdU, NapdC, ThdU, 
       O, MOEdU, 2NapdU, BTdU, POPdU, 2NEdU, iBudU, MBndU, BPEdU, FBndU,
       NapdU, TrpdU, BndU, PBndU, NEdU, PEdU, BFdU, or PPdU

<220>
<221>  misc_feature
<222>  (1)..(29)
<223>  See specification as filed for detailed description of 
       substitutions and preferred embodiments

<400>  98
ggganannan gngnnngann gnnnggang                                         29


<210>  99
<211>  29
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Synthetic: 26874-29_123


<220>
<221>  misc_feature
<222>  (1)..(29)
<223>  Every n is a C-5 modified pyrimidine such as TyrdU, NapdC, ThdU, 
       O, MOEdU, 2NapdU, BTdU, POPdU, 2NEdU, iBudU, MBndU, BPEdU, FBndU,
       NapdU, TrpdU, BndU, PBndU, NEdU, PEdU, BFdU, or PPdU

<220>
<221>  misc_feature
<222>  (1)..(29)
<223>  See specification as filed for detailed description of 
       substitutions and preferred embodiments

<400>  99
ggganannan gngnnngann gnnnggang                                         29


<210>  100
<211>  29
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Synthetic: 26874-29_124


<220>
<221>  misc_feature
<222>  (1)..(29)
<223>  Every n is a C-5 modified pyrimidine such as TyrdU, NapdC, ThdU, 
       O, MOEdU, 2NapdU, BTdU, POPdU, 2NEdU, iBudU, MBndU, BPEdU, FBndU,
       NapdU, TrpdU, BndU, PBndU, NEdU, PEdU, BFdU, or PPdU

<220>
<221>  misc_feature
<222>  (1)..(29)
<223>  See specification as filed for detailed description of 
       substitutions and preferred embodiments

<400>  100
ggganannan gngnnngann gnnnggang                                         29


<210>  101
<211>  29
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Synthetic: 26874-29_125


<220>
<221>  misc_feature
<222>  (1)..(29)
<223>  Every n is a C-5 modified pyrimidine such as TyrdU, NapdC, ThdU, 
       O, MOEdU, 2NapdU, BTdU, POPdU, 2NEdU, iBudU, MBndU, BPEdU, FBndU,
       NapdU, TrpdU, BndU, PBndU, NEdU, PEdU, BFdU, or PPdU

<220>
<221>  misc_feature
<222>  (1)..(29)
<223>  See specification as filed for detailed description of 
       substitutions and preferred embodiments

<400>  101
ggganannan gngnnngann gnnnggang                                         29


<210>  102
<211>  29
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Synthetic: 26874-29_126


<220>
<221>  misc_feature
<222>  (1)..(29)
<223>  Every n is a C-5 modified pyrimidine such as TyrdU, NapdC, ThdU, 
       O, MOEdU, 2NapdU, BTdU, POPdU, 2NEdU, iBudU, MBndU, BPEdU, FBndU,
       NapdU, TrpdU, BndU, PBndU, NEdU, PEdU, BFdU, or PPdU

<220>
<221>  misc_feature
<222>  (1)..(29)
<223>  See specification as filed for detailed description of 
       substitutions and preferred embodiments

<400>  102
ggganannan gngnnngann gnnnggang                                         29


<210>  103
<211>  29
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Synthetic: 26874-29_127


<220>
<221>  misc_feature
<222>  (1)..(29)
<223>  Every n is a C-5 modified pyrimidine such as TyrdU, NapdC, ThdU, 
       O, MOEdU, 2NapdU, BTdU, POPdU, 2NEdU, iBudU, MBndU, BPEdU, FBndU,
       NapdU, TrpdU, BndU, PBndU, NEdU, PEdU, BFdU, or PPdU

<220>
<221>  misc_feature
<222>  (1)..(29)
<223>  See specification as filed for detailed description of 
       substitutions and preferred embodiments

<400>  103
gggacannan gngnnngann gnnnggang                                         29


<210>  104
<211>  29
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Synthetic: 26874-29_128


<220>
<221>  misc_feature
<222>  (1)..(29)
<223>  Every n is a C-5 modified pyrimidine such as TyrdU, NapdC, ThdU, 
       O, MOEdU, 2NapdU, BTdU, POPdU, 2NEdU, iBudU, MBndU, BPEdU, FBndU,
       NapdU, TrpdU, BndU, PBndU, NEdU, PEdU, BFdU, or PPdU

<220>
<221>  misc_feature
<222>  (1)..(29)
<223>  See specification as filed for detailed description of 
       substitutions and preferred embodiments

<400>  104
ggganannan gngnnngann gnnnggang                                         29


<210>  105
<211>  29
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Synthetic: 26874-29_130


<220>
<221>  misc_feature
<222>  (1)..(29)
<223>  Every n is a C-5 modified pyrimidine such as TyrdU, NapdC, ThdU, 
       O, MOEdU, 2NapdU, BTdU, POPdU, 2NEdU, iBudU, MBndU, BPEdU, FBndU,
       NapdU, TrpdU, BndU, PBndU, NEdU, PEdU, BFdU, or PPdU

<220>
<221>  misc_feature
<222>  (1)..(29)
<223>  See specification as filed for detailed description of 
       substitutions and preferred embodiments

<400>  105
ggganannan gngnnngann gnnnggang                                         29


<210>  106
<211>  29
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Synthetic: 26874-29_132


<220>
<221>  misc_feature
<222>  (1)..(29)
<223>  Every n is a C-5 modified pyrimidine such as TyrdU, NapdC, ThdU, 
       O, MOEdU, 2NapdU, BTdU, POPdU, 2NEdU, iBudU, MBndU, BPEdU, FBndU,
       NapdU, TrpdU, BndU, PBndU, NEdU, PEdU, BFdU, or PPdU

<220>
<221>  misc_feature
<222>  (1)..(29)
<223>  See specification as filed for detailed description of 
       substitutions and preferred embodiments

<400>  106
ggganannan gngnnngann gnnnggang                                         29


<210>  107
<211>  29
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Synthetic: 26874-29_134


<220>
<221>  misc_feature
<222>  (1)..(29)
<223>  Every n is a C-5 modified pyrimidine such as TyrdU, NapdC, ThdU, 
       O, MOEdU, 2NapdU, BTdU, POPdU, 2NEdU, iBudU, MBndU, BPEdU, FBndU,
       NapdU, TrpdU, BndU, PBndU, NEdU, PEdU, BFdU, or PPdU

<220>
<221>  misc_feature
<222>  (1)..(29)
<223>  See specification as filed for detailed description of 
       substitutions and preferred embodiments

<400>  107
ggganannan gngnnngann gnnnggang                                         29


<210>  108
<211>  29
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Synthetic: 26874-29_136


<220>
<221>  misc_feature
<222>  (1)..(29)
<223>  Every n is a C-5 modified pyrimidine such as TyrdU, NapdC, ThdU, 
       O, MOEdU, 2NapdU, BTdU, POPdU, 2NEdU, iBudU, MBndU, BPEdU, FBndU,
       NapdU, TrpdU, BndU, PBndU, NEdU, PEdU, BFdU, or PPdU

<220>
<221>  misc_feature
<222>  (1)..(29)
<223>  See specification as filed for detailed description of 
       substitutions and preferred embodiments

<400>  108
ggganannan gngnnngann gnnnggang                                         29


<210>  109
<211>  29
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Synthetic: 26874-29_138


<220>
<221>  misc_feature
<222>  (1)..(29)
<223>  Every n is a C-5 modified pyrimidine such as TyrdU, NapdC, ThdU, 
       O, MOEdU, 2NapdU, BTdU, POPdU, 2NEdU, iBudU, MBndU, BPEdU, FBndU,
       NapdU, TrpdU, BndU, PBndU, NEdU, PEdU, BFdU, or PPdU

<220>
<221>  misc_feature
<222>  (1)..(29)
<223>  See specification as filed for detailed description of 
       substitutions and preferred embodiments

<400>  109
ggganannan gngnnngann gnnnggang                                         29


<210>  110
<211>  29
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Synthetic: 26874-29_140


<220>
<221>  misc_feature
<222>  (1)..(29)
<223>  Every n is a C-5 modified pyrimidine such as TyrdU, NapdC, ThdU, 
       O, MOEdU, 2NapdU, BTdU, POPdU, 2NEdU, iBudU, MBndU, BPEdU, FBndU,
       NapdU, TrpdU, BndU, PBndU, NEdU, PEdU, BFdU, or PPdU

<220>
<221>  misc_feature
<222>  (1)..(29)
<223>  See specification as filed for detailed description of 
       substitutions and preferred embodiments

<400>  110
ggganannan gngnnngann gnnnggang                                         29


<210>  111
<211>  29
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Synthetic: 26874-29_142


<220>
<221>  misc_feature
<222>  (1)..(29)
<223>  Every n is a C-5 modified pyrimidine such as TyrdU, NapdC, ThdU, 
       O, MOEdU, 2NapdU, BTdU, POPdU, 2NEdU, iBudU, MBndU, BPEdU, FBndU,
       NapdU, TrpdU, BndU, PBndU, NEdU, PEdU, BFdU, or PPdU

<220>
<221>  misc_feature
<222>  (1)..(29)
<223>  See specification as filed for detailed description of 
       substitutions and preferred embodiments

<400>  111
ggganannan gngnnngann gnnnggang                                         29


<210>  112
<211>  29
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Synthetic: 26874-29_144


<220>
<221>  misc_feature
<222>  (1)..(29)
<223>  Every n is a C-5 modified pyrimidine such as TyrdU, NapdC, ThdU, 
       O, MOEdU, 2NapdU, BTdU, POPdU, 2NEdU, iBudU, MBndU, BPEdU, FBndU,
       NapdU, TrpdU, BndU, PBndU, NEdU, PEdU, BFdU, or PPdU

<220>
<221>  misc_feature
<222>  (1)..(29)
<223>  See specification as filed for detailed description of 
       substitutions and preferred embodiments

<400>  112
ggganannan gngnnngann gnnnggang                                         29


<210>  113
<211>  29
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Synthetic: 26874-29_146


<220>
<221>  misc_feature
<222>  (1)..(29)
<223>  Every n is a C-5 modified pyrimidine such as TyrdU, NapdC, ThdU, 
       O, MOEdU, 2NapdU, BTdU, POPdU, 2NEdU, iBudU, MBndU, BPEdU, FBndU,
       NapdU, TrpdU, BndU, PBndU, NEdU, PEdU, BFdU, or PPdU

<220>
<221>  misc_feature
<222>  (1)..(29)
<223>  See specification as filed for detailed description of 
       substitutions and preferred embodiments

<400>  113
ggganannan gngnnngann gnnnggang                                         29


<210>  114
<211>  29
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Synthetic: 26874-29_147


<220>
<221>  misc_feature
<222>  (1)..(29)
<223>  Every n is a C-5 modified pyrimidine such as TyrdU, NapdC, ThdU, 
       O, MOEdU, 2NapdU, BTdU, POPdU, 2NEdU, iBudU, MBndU, BPEdU, FBndU,
       NapdU, TrpdU, BndU, PBndU, NEdU, PEdU, BFdU, or PPdU

<220>
<221>  misc_feature
<222>  (1)..(29)
<223>  See specification as filed for detailed description of 
       substitutions and preferred embodiments

<400>  114
ggganannan gngnnngann gnnnggang                                         29


<210>  115
<211>  29
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Synthetic: 26874-29_148


<220>
<221>  misc_feature
<222>  (1)..(29)
<223>  Every n is a C-5 modified pyrimidine such as TyrdU, NapdC, ThdU, 
       O, MOEdU, 2NapdU, BTdU, POPdU, 2NEdU, iBudU, MBndU, BPEdU, FBndU,
       NapdU, TrpdU, BndU, PBndU, NEdU, PEdU, BFdU, or PPdU

<220>
<221>  misc_feature
<222>  (1)..(29)
<223>  See specification as filed for detailed description of 
       substitutions and preferred embodiments

<400>  115
ggganannan gngnnngann gnnnggang                                         29


<210>  116
<211>  29
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Synthetic: 26874-29_149


<220>
<221>  misc_feature
<222>  (1)..(29)
<223>  Every n is a C-5 modified pyrimidine such as TyrdU, NapdC, ThdU, 
       O, MOEdU, 2NapdU, BTdU, POPdU, 2NEdU, iBudU, MBndU, BPEdU, FBndU,
       NapdU, TrpdU, BndU, PBndU, NEdU, PEdU, BFdU, or PPdU

<220>
<221>  misc_feature
<222>  (1)..(29)
<223>  See specification as filed for detailed description of 
       substitutions and preferred embodiments

<400>  116
ggganannan gngnnngann gnnnggang                                         29


<210>  117
<211>  29
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Synthetic: 26874-29_150


<220>
<221>  misc_feature
<222>  (1)..(29)
<223>  Every n is a C-5 modified pyrimidine such as TyrdU, NapdC, ThdU, 
       O, MOEdU, 2NapdU, BTdU, POPdU, 2NEdU, iBudU, MBndU, BPEdU, FBndU,
       NapdU, TrpdU, BndU, PBndU, NEdU, PEdU, BFdU, or PPdU

<220>
<221>  misc_feature
<222>  (1)..(29)
<223>  See specification as filed for detailed description of 
       substitutions and preferred embodiments

<400>  117
ggganannan gngnnngann gnnnggang                                         29


<210>  118
<211>  29
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Synthetic: 26874-29_151


<220>
<221>  misc_feature
<222>  (1)..(29)
<223>  Every n is a C-5 modified pyrimidine such as TyrdU, NapdC, ThdU, 
       O, MOEdU, 2NapdU, BTdU, POPdU, 2NEdU, iBudU, MBndU, BPEdU, FBndU,
       NapdU, TrpdU, BndU, PBndU, NEdU, PEdU, BFdU, or PPdU

<220>
<221>  misc_feature
<222>  (1)..(29)
<223>  See specification as filed for detailed description of 
       substitutions and preferred embodiments

<400>  118
ggganannan gngnnngann gnnnggang                                         29


<210>  119
<211>  29
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Synthetic: 26874-29_152


<220>
<221>  misc_feature
<222>  (1)..(29)
<223>  Every n is a C-5 modified pyrimidine such as TyrdU, NapdC, ThdU, 
       O, MOEdU, 2NapdU, BTdU, POPdU, 2NEdU, iBudU, MBndU, BPEdU, FBndU,
       NapdU, TrpdU, BndU, PBndU, NEdU, PEdU, BFdU, or PPdU

<220>
<221>  misc_feature
<222>  (1)..(29)
<223>  See specification as filed for detailed description of 
       substitutions and preferred embodiments

<400>  119
ggganannan gngnnngann gnnnggang                                         29


<210>  120
<211>  29
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Synthetic: 26874-29_153


<220>
<221>  misc_feature
<222>  (1)..(29)
<223>  Every n is a C-5 modified pyrimidine such as TyrdU, NapdC, ThdU, 
       O, MOEdU, 2NapdU, BTdU, POPdU, 2NEdU, iBudU, MBndU, BPEdU, FBndU,
       NapdU, TrpdU, BndU, PBndU, NEdU, PEdU, BFdU, or PPdU

<220>
<221>  misc_feature
<222>  (1)..(29)
<223>  See specification as filed for detailed description of 
       substitutions and preferred embodiments

<400>  120
ggganannan gngnnngann gnnnggang                                         29


<210>  121
<211>  29
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Synthetic: 26874-29_154


<220>
<221>  misc_feature
<222>  (1)..(29)
<223>  Every n is a C-5 modified pyrimidine such as TyrdU, NapdC, ThdU, 
       O, MOEdU, 2NapdU, BTdU, POPdU, 2NEdU, iBudU, MBndU, BPEdU, FBndU,
       NapdU, TrpdU, BndU, PBndU, NEdU, PEdU, BFdU, or PPdU

<220>
<221>  misc_feature
<222>  (1)..(29)
<223>  See specification as filed for detailed description of 
       substitutions and preferred embodiments

<400>  121
ggganannan gngnnngann gnnnggang                                         29


<210>  122
<211>  29
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Synthetic: 26874-29_155


<220>
<221>  misc_feature
<222>  (1)..(29)
<223>  Every n is a C-5 modified pyrimidine such as TyrdU, NapdC, ThdU, 
       O, MOEdU, 2NapdU, BTdU, POPdU, 2NEdU, iBudU, MBndU, BPEdU, FBndU,
       NapdU, TrpdU, BndU, PBndU, NEdU, PEdU, BFdU, or PPdU

<220>
<221>  misc_feature
<222>  (1)..(29)
<223>  See specification as filed for detailed description of 
       substitutions and preferred embodiments

<400>  122
ggganannan gngnnngann gnnnggang                                         29


<210>  123
<211>  1270
<212>  PRT
<213>  SARS-CoV-2


<220>
<221>  misc_feature
<222>  (1)..(1270)
<223>  Spike S1 & S2 ECD B1.1.7 variant (Alpha)

<400>  123

Met Phe Val Phe Leu Val Leu Leu Pro Leu Val Ser Ser Gln Cys Val 
1               5                   10                  15      


Asn Leu Thr Thr Arg Thr Gln Leu Pro Pro Ala Tyr Thr Asn Ser Phe 
            20                  25                  30          


Thr Arg Gly Val Tyr Tyr Pro Asp Lys Val Phe Arg Ser Ser Val Leu 
        35                  40                  45              


His Ser Thr Gln Asp Leu Phe Leu Pro Phe Phe Ser Asn Val Thr Trp 
    50                  55                  60                  


Phe His Ala Ile Ser Gly Thr Asn Gly Thr Lys Arg Phe Asp Asn Pro 
65                  70                  75                  80  


Val Leu Pro Phe Asn Asp Gly Val Tyr Phe Ala Ser Thr Glu Lys Ser 
                85                  90                  95      


Asn Ile Ile Arg Gly Trp Ile Phe Gly Thr Thr Leu Asp Ser Lys Thr 
            100                 105                 110         


Gln Ser Leu Leu Ile Val Asn Asn Ala Thr Asn Val Val Ile Lys Val 
        115                 120                 125             


Cys Glu Phe Gln Phe Cys Asn Asp Pro Phe Leu Gly Val Tyr His Lys 
    130                 135                 140                 


Asn Asn Lys Ser Trp Met Glu Ser Glu Phe Arg Val Tyr Ser Ser Ala 
145                 150                 155                 160 


Asn Asn Cys Thr Phe Glu Tyr Val Ser Gln Pro Phe Leu Met Asp Leu 
                165                 170                 175     


Glu Gly Lys Gln Gly Asn Phe Lys Asn Leu Arg Glu Phe Val Phe Lys 
            180                 185                 190         


Asn Ile Asp Gly Tyr Phe Lys Ile Tyr Ser Lys His Thr Pro Ile Asn 
        195                 200                 205             


Leu Val Arg Asp Leu Pro Gln Gly Phe Ser Ala Leu Glu Pro Leu Val 
    210                 215                 220                 


Asp Leu Pro Ile Gly Ile Asn Ile Thr Arg Phe Gln Thr Leu Leu Ala 
225                 230                 235                 240 


Leu His Arg Ser Tyr Leu Thr Pro Gly Asp Ser Ser Ser Gly Trp Thr 
                245                 250                 255     


Ala Gly Ala Ala Ala Tyr Tyr Val Gly Tyr Leu Gln Pro Arg Thr Phe 
            260                 265                 270         


Leu Leu Lys Tyr Asn Glu Asn Gly Thr Ile Thr Asp Ala Val Asp Cys 
        275                 280                 285             


Ala Leu Asp Pro Leu Ser Glu Thr Lys Cys Thr Leu Lys Ser Phe Thr 
    290                 295                 300                 


Val Glu Lys Gly Ile Tyr Gln Thr Ser Asn Phe Arg Val Gln Pro Thr 
305                 310                 315                 320 


Glu Ser Ile Val Arg Phe Pro Asn Ile Thr Asn Leu Cys Pro Phe Gly 
                325                 330                 335     


Glu Val Phe Asn Ala Thr Arg Phe Ala Ser Val Tyr Ala Trp Asn Arg 
            340                 345                 350         


Lys Arg Ile Ser Asn Cys Val Ala Asp Tyr Ser Val Leu Tyr Asn Ser 
        355                 360                 365             


Ala Ser Phe Ser Thr Phe Lys Cys Tyr Gly Val Ser Pro Thr Lys Leu 
    370                 375                 380                 


Asn Asp Leu Cys Phe Thr Asn Val Tyr Ala Asp Ser Phe Val Ile Arg 
385                 390                 395                 400 


Gly Asp Glu Val Arg Gln Ile Ala Pro Gly Gln Thr Gly Lys Ile Ala 
                405                 410                 415     


Asp Tyr Asn Tyr Lys Leu Pro Asp Asp Phe Thr Gly Cys Val Ile Ala 
            420                 425                 430         


Trp Asn Ser Asn Asn Leu Asp Ser Lys Val Gly Gly Asn Tyr Asn Tyr 
        435                 440                 445             


Leu Tyr Arg Leu Phe Arg Lys Ser Asn Leu Lys Pro Phe Glu Arg Asp 
    450                 455                 460                 


Ile Ser Thr Glu Ile Tyr Gln Ala Gly Ser Thr Pro Cys Asn Gly Val 
465                 470                 475                 480 


Lys Gly Phe Asn Cys Tyr Phe Pro Leu Gln Pro Tyr Gly Phe Gln Pro 
                485                 490                 495     


Thr Tyr Gly Val Gly Tyr Gln Pro Tyr Arg Val Val Val Leu Ser Phe 
            500                 505                 510         


Glu Leu Leu His Ala Pro Ala Thr Val Cys Gly Pro Lys Lys Ser Thr 
        515                 520                 525             


Asn Leu Val Lys Asn Lys Cys Val Asn Phe Asn Phe Asn Gly Leu Thr 
    530                 535                 540                 


Gly Thr Gly Val Leu Thr Glu Ser Asn Lys Lys Phe Leu Pro Phe Gln 
545                 550                 555                 560 


Gln Phe Gly Arg Asp Ile Asp Asp Thr Thr Asp Ala Val Arg Asp Pro 
                565                 570                 575     


Gln Thr Leu Glu Ile Leu Asp Ile Thr Pro Cys Ser Phe Gly Gly Val 
            580                 585                 590         


Ser Val Ile Thr Pro Gly Thr Asn Thr Ser Asn Gln Val Ala Val Leu 
        595                 600                 605             


Tyr Gln Gly Val Asn Cys Thr Glu Val Pro Val Ala Ile His Ala Asp 
    610                 615                 620                 


Gln Leu Thr Pro Thr Trp Arg Val Tyr Ser Thr Gly Ser Asn Val Phe 
625                 630                 635                 640 


Gln Thr Arg Ala Gly Cys Leu Ile Gly Ala Glu His Val Asn Asn Ser 
                645                 650                 655     


Tyr Glu Cys Asp Ile Pro Ile Gly Ala Gly Ile Cys Ala Ser Tyr Gln 
            660                 665                 670         


Thr Gln Thr Asn Ser His Arg Arg Ala Arg Ser Val Ala Ser Gln Ser 
        675                 680                 685             


Ile Ile Ala Tyr Thr Met Ser Leu Gly Ala Glu Asn Ser Val Ala Tyr 
    690                 695                 700                 


Ser Asn Asn Ser Ile Ala Ile Pro Ile Asn Phe Thr Ile Ser Val Thr 
705                 710                 715                 720 


Thr Glu Ile Leu Pro Val Ser Met Thr Lys Thr Ser Val Asp Cys Thr 
                725                 730                 735     


Met Tyr Ile Cys Gly Asp Ser Thr Glu Cys Ser Asn Leu Leu Leu Gln 
            740                 745                 750         


Tyr Gly Ser Phe Cys Thr Gln Leu Asn Arg Ala Leu Thr Gly Ile Ala 
        755                 760                 765             


Val Glu Gln Asp Lys Asn Thr Gln Glu Val Phe Ala Gln Val Lys Gln 
    770                 775                 780                 


Ile Tyr Lys Thr Pro Pro Ile Lys Asp Phe Gly Gly Phe Asn Phe Ser 
785                 790                 795                 800 


Gln Ile Leu Pro Asp Pro Ser Lys Pro Ser Lys Arg Ser Phe Ile Glu 
                805                 810                 815     


Asp Leu Leu Phe Asn Lys Val Thr Leu Ala Asp Ala Gly Phe Ile Lys 
            820                 825                 830         


Gln Tyr Gly Asp Cys Leu Gly Asp Ile Ala Ala Arg Asp Leu Ile Cys 
        835                 840                 845             


Ala Gln Lys Phe Asn Gly Leu Thr Val Leu Pro Pro Leu Leu Thr Asp 
    850                 855                 860                 


Glu Met Ile Ala Gln Tyr Thr Ser Ala Leu Leu Ala Gly Thr Ile Thr 
865                 870                 875                 880 


Ser Gly Trp Thr Phe Gly Ala Gly Ala Ala Leu Gln Ile Pro Phe Ala 
                885                 890                 895     


Met Gln Met Ala Tyr Arg Phe Asn Gly Ile Gly Val Thr Gln Asn Val 
            900                 905                 910         


Leu Tyr Glu Asn Gln Lys Leu Ile Ala Asn Gln Phe Asn Ser Ala Ile 
        915                 920                 925             


Gly Lys Ile Gln Asp Ser Leu Ser Ser Thr Ala Ser Ala Leu Gly Lys 
    930                 935                 940                 


Leu Gln Asp Val Val Asn Gln Asn Ala Gln Ala Leu Asn Thr Leu Val 
945                 950                 955                 960 


Lys Gln Leu Ser Ser Asn Phe Gly Ala Ile Ser Ser Val Leu Asn Asp 
                965                 970                 975     


Ile Leu Ala Arg Leu Asp Lys Val Glu Ala Glu Val Gln Ile Asp Arg 
            980                 985                 990         


Leu Ile Thr Gly Arg Leu Gln Ser  Leu Gln Thr Tyr Val  Thr Gln Gln 
        995                 1000                 1005             


Leu Ile  Arg Ala Ala Glu Ile  Arg Ala Ser Ala Asn  Leu Ala Ala 
    1010                 1015                 1020             


Thr Lys  Met Ser Glu Cys Val  Leu Gly Gln Ser Lys  Arg Val Asp 
    1025                 1030                 1035             


Phe Cys  Gly Lys Gly Tyr His  Leu Met Ser Phe Pro  Gln Ser Ala 
    1040                 1045                 1050             


Pro His  Gly Val Val Phe Leu  His Val Thr Tyr Val  Pro Ala Gln 
    1055                 1060                 1065             


Glu Lys  Asn Phe Thr Thr Ala  Pro Ala Ile Cys His  Asp Gly Lys 
    1070                 1075                 1080             


Ala His  Phe Pro Arg Glu Gly  Val Phe Val Ser Asn  Gly Thr His 
    1085                 1090                 1095             


Trp Phe  Val Thr Gln Arg Asn  Phe Tyr Glu Pro Gln  Ile Ile Thr 
    1100                 1105                 1110             


Thr His  Asn Thr Phe Val Ser  Gly Asn Cys Asp Val  Val Ile Gly 
    1115                 1120                 1125             


Ile Val  Asn Asn Thr Val Tyr  Asp Pro Leu Gln Pro  Glu Leu Asp 
    1130                 1135                 1140             


Ser Phe  Lys Glu Glu Leu Asp  Lys Tyr Phe Lys Asn  His Thr Ser 
    1145                 1150                 1155             


Pro Asp  Val Asp Leu Gly Asp  Ile Ser Gly Ile Asn  Ala Ser Val 
    1160                 1165                 1170             


Val Asn  Ile Gln Lys Glu Ile  Asp Arg Leu Asn Glu  Val Ala Asn 
    1175                 1180                 1185             


Asn Leu  Asn Glu Ser Leu Ile  Asp Leu Gln Glu Leu  Gly Lys Tyr 
    1190                 1195                 1200             


Glu Gln  Tyr Ile Lys Trp Pro  Trp Tyr Ile Trp Leu  Gly Phe Ile 
    1205                 1210                 1215             


Ala Gly  Leu Ile Ala Ile Val  Met Val Thr Ile Met  Leu Cys Cys 
    1220                 1225                 1230             


Met Thr  Ser Cys Cys Ser Cys  Leu Lys Gly Cys Cys  Ser Cys Gly 
    1235                 1240                 1245             


Ser Cys  Cys Lys Phe Asp Glu  Asp Asp Ser Glu Pro  Val Leu Lys 
    1250                 1255                 1260             


Gly Val  Lys Leu His Tyr Thr  
    1265                 1270 


<210>  124
<211>  1270
<212>  PRT
<213>  SARS-CoV-2


<220>
<221>  misc_feature
<222>  (1)..(1270)
<223>  Spike S1 & S2 ECD B1.351 variant (Beta)

<400>  124

Met Phe Val Phe Leu Val Leu Leu Pro Leu Val Ser Ser Gln Cys Val 
1               5                   10                  15      


Asn Leu Thr Thr Arg Thr Gln Leu Pro Pro Ala Tyr Thr Asn Ser Phe 
            20                  25                  30          


Thr Arg Gly Val Tyr Tyr Pro Asp Lys Val Phe Arg Ser Ser Val Leu 
        35                  40                  45              


His Ser Thr Gln Asp Leu Phe Leu Pro Phe Phe Ser Asn Val Thr Trp 
    50                  55                  60                  


Phe His Ala Ile His Val Ser Gly Thr Asn Gly Thr Lys Arg Phe Ala 
65                  70                  75                  80  


Asn Pro Val Leu Pro Phe Asn Asp Gly Val Tyr Phe Ala Ser Thr Glu 
                85                  90                  95      


Lys Ser Asn Ile Ile Arg Gly Trp Ile Phe Gly Thr Thr Leu Asp Ser 
            100                 105                 110         


Lys Thr Gln Ser Leu Leu Ile Val Asn Asn Ala Thr Asn Val Val Ile 
        115                 120                 125             


Lys Val Cys Glu Phe Gln Phe Cys Asn Asp Pro Phe Leu Gly Val Tyr 
    130                 135                 140                 


Tyr His Lys Asn Asn Lys Ser Trp Met Glu Ser Glu Phe Arg Val Tyr 
145                 150                 155                 160 


Ser Ser Ala Asn Asn Cys Thr Phe Glu Tyr Val Ser Gln Pro Phe Leu 
                165                 170                 175     


Met Asp Leu Glu Gly Lys Gln Gly Asn Phe Lys Asn Leu Arg Glu Phe 
            180                 185                 190         


Val Phe Lys Asn Ile Asp Gly Tyr Phe Lys Ile Tyr Ser Lys His Thr 
        195                 200                 205             


Pro Ile Asn Leu Val Arg Gly Leu Pro Gln Gly Phe Ser Ala Leu Glu 
    210                 215                 220                 


Pro Leu Val Asp Leu Pro Ile Gly Ile Asn Ile Thr Arg Phe Gln Thr 
225                 230                 235                 240 


Leu His Arg Ser Tyr Leu Thr Pro Gly Asp Ser Ser Ser Gly Trp Thr 
                245                 250                 255     


Ala Gly Ala Ala Ala Tyr Tyr Val Gly Tyr Leu Gln Pro Arg Thr Phe 
            260                 265                 270         


Leu Leu Lys Tyr Asn Glu Asn Gly Thr Ile Thr Asp Ala Val Asp Cys 
        275                 280                 285             


Ala Leu Asp Pro Leu Ser Glu Thr Lys Cys Thr Leu Lys Ser Phe Thr 
    290                 295                 300                 


Val Glu Lys Gly Ile Tyr Gln Thr Ser Asn Phe Arg Val Gln Pro Thr 
305                 310                 315                 320 


Glu Ser Ile Val Arg Phe Pro Asn Ile Thr Asn Leu Cys Pro Phe Gly 
                325                 330                 335     


Glu Val Phe Asn Ala Thr Arg Phe Ala Ser Val Tyr Ala Trp Asn Arg 
            340                 345                 350         


Lys Arg Ile Ser Asn Cys Val Ala Asp Tyr Ser Val Leu Tyr Asn Ser 
        355                 360                 365             


Ala Ser Phe Ser Thr Phe Lys Cys Tyr Gly Val Ser Pro Thr Lys Leu 
    370                 375                 380                 


Asn Asp Leu Cys Phe Thr Asn Val Tyr Ala Asp Ser Phe Val Ile Arg 
385                 390                 395                 400 


Gly Asp Glu Val Arg Gln Ile Ala Pro Gly Gln Thr Gly Asn Ile Ala 
                405                 410                 415     


Asp Tyr Asn Tyr Lys Leu Pro Asp Asp Phe Thr Gly Cys Val Ile Ala 
            420                 425                 430         


Trp Asn Ser Asn Asn Leu Asp Ser Lys Val Gly Gly Asn Tyr Asn Tyr 
        435                 440                 445             


Leu Tyr Arg Leu Phe Arg Lys Ser Asn Leu Lys Pro Phe Glu Arg Asp 
    450                 455                 460                 


Ile Ser Thr Glu Ile Tyr Gln Ala Gly Ser Thr Pro Cys Asn Gly Val 
465                 470                 475                 480 


Lys Gly Phe Asn Cys Tyr Phe Pro Leu Gln Ser Tyr Gly Phe Gln Pro 
                485                 490                 495     


Thr Tyr Gly Val Gly Tyr Gln Pro Tyr Arg Val Val Val Leu Ser Phe 
            500                 505                 510         


Glu Leu Leu His Ala Pro Ala Thr Val Cys Gly Pro Lys Lys Ser Thr 
        515                 520                 525             


Asn Leu Val Lys Asn Lys Cys Val Asn Phe Asn Phe Asn Gly Leu Thr 
    530                 535                 540                 


Gly Thr Gly Val Leu Thr Glu Ser Asn Lys Lys Phe Leu Pro Phe Gln 
545                 550                 555                 560 


Gln Phe Gly Arg Asp Ile Ala Asp Thr Thr Asp Ala Val Arg Asp Pro 
                565                 570                 575     


Gln Thr Leu Glu Ile Leu Asp Ile Thr Pro Cys Ser Phe Gly Gly Val 
            580                 585                 590         


Ser Val Ile Thr Pro Gly Thr Asn Thr Ser Asn Gln Val Ala Val Leu 
        595                 600                 605             


Tyr Gln Gly Val Asn Cys Thr Glu Val Pro Val Ala Ile His Ala Asp 
    610                 615                 620                 


Gln Leu Thr Pro Thr Trp Arg Val Tyr Ser Thr Gly Ser Asn Val Phe 
625                 630                 635                 640 


Gln Thr Arg Ala Gly Cys Leu Ile Gly Ala Glu His Val Asn Asn Ser 
                645                 650                 655     


Tyr Glu Cys Asp Ile Pro Ile Gly Ala Gly Ile Cys Ala Ser Tyr Gln 
            660                 665                 670         


Thr Gln Thr Asn Ser Pro Arg Arg Ala Arg Ser Val Ala Ser Gln Ser 
        675                 680                 685             


Ile Ile Ala Tyr Thr Met Ser Leu Gly Val Glu Asn Ser Val Ala Tyr 
    690                 695                 700                 


Ser Asn Asn Ser Ile Ala Ile Pro Thr Asn Phe Thr Ile Ser Val Thr 
705                 710                 715                 720 


Thr Glu Ile Leu Pro Val Ser Met Thr Lys Thr Ser Val Asp Cys Thr 
                725                 730                 735     


Met Tyr Ile Cys Gly Asp Ser Thr Glu Cys Ser Asn Leu Leu Leu Gln 
            740                 745                 750         


Tyr Gly Ser Phe Cys Thr Gln Leu Asn Arg Ala Leu Thr Gly Ile Ala 
        755                 760                 765             


Val Glu Gln Asp Lys Asn Thr Gln Glu Val Phe Ala Gln Val Lys Gln 
    770                 775                 780                 


Ile Tyr Lys Thr Pro Pro Ile Lys Asp Phe Gly Gly Phe Asn Phe Ser 
785                 790                 795                 800 


Gln Ile Leu Pro Asp Pro Ser Lys Pro Ser Lys Arg Ser Phe Ile Glu 
                805                 810                 815     


Asp Leu Leu Phe Asn Lys Val Thr Leu Ala Asp Ala Gly Phe Ile Lys 
            820                 825                 830         


Gln Tyr Gly Asp Cys Leu Gly Asp Ile Ala Ala Arg Asp Leu Ile Cys 
        835                 840                 845             


Ala Gln Lys Phe Asn Gly Leu Thr Val Leu Pro Pro Leu Leu Thr Asp 
    850                 855                 860                 


Glu Met Ile Ala Gln Tyr Thr Ser Ala Leu Leu Ala Gly Thr Ile Thr 
865                 870                 875                 880 


Ser Gly Trp Thr Phe Gly Ala Gly Ala Ala Leu Gln Ile Pro Phe Ala 
                885                 890                 895     


Met Gln Met Ala Tyr Arg Phe Asn Gly Ile Gly Val Thr Gln Asn Val 
            900                 905                 910         


Leu Tyr Glu Asn Gln Lys Leu Ile Ala Asn Gln Phe Asn Ser Ala Ile 
        915                 920                 925             


Gly Lys Ile Gln Asp Ser Leu Ser Ser Thr Ala Ser Ala Leu Gly Lys 
    930                 935                 940                 


Leu Gln Asp Val Val Asn Gln Asn Ala Gln Ala Leu Asn Thr Leu Val 
945                 950                 955                 960 


Lys Gln Leu Ser Ser Asn Phe Gly Ala Ile Ser Ser Val Leu Asn Asp 
                965                 970                 975     


Ile Leu Ser Arg Leu Asp Lys Val Glu Ala Glu Val Gln Ile Asp Arg 
            980                 985                 990         


Leu Ile Thr Gly Arg Leu Gln Ser  Leu Gln Thr Tyr Val  Thr Gln Gln 
        995                 1000                 1005             


Leu Ile  Arg Ala Ala Glu Ile  Arg Ala Ser Ala Asn  Leu Ala Ala 
    1010                 1015                 1020             


Thr Lys  Met Ser Glu Cys Val  Leu Gly Gln Ser Lys  Arg Val Asp 
    1025                 1030                 1035             


Phe Cys  Gly Lys Gly Tyr His  Leu Met Ser Phe Pro  Gln Ser Ala 
    1040                 1045                 1050             


Pro His  Gly Val Val Phe Leu  His Val Thr Tyr Val  Pro Ala Gln 
    1055                 1060                 1065             


Glu Lys  Asn Phe Thr Thr Ala  Pro Ala Ile Cys His  Asp Gly Lys 
    1070                 1075                 1080             


Ala His  Phe Pro Arg Glu Gly  Val Phe Val Ser Asn  Gly Thr His 
    1085                 1090                 1095             


Trp Phe  Val Thr Gln Arg Asn  Phe Tyr Glu Pro Gln  Ile Ile Thr 
    1100                 1105                 1110             


Thr Asp  Asn Thr Phe Val Ser  Gly Asn Cys Asp Val  Val Ile Gly 
    1115                 1120                 1125             


Ile Val  Asn Asn Thr Val Tyr  Asp Pro Leu Gln Pro  Glu Leu Asp 
    1130                 1135                 1140             


Ser Phe  Lys Glu Glu Leu Asp  Lys Tyr Phe Lys Asn  His Thr Ser 
    1145                 1150                 1155             


Pro Asp  Val Asp Leu Gly Asp  Ile Ser Gly Ile Asn  Ala Ser Val 
    1160                 1165                 1170             


Val Asn  Ile Gln Lys Glu Ile  Asp Arg Leu Asn Glu  Val Ala Lys 
    1175                 1180                 1185             


Asn Leu  Asn Glu Ser Leu Ile  Asp Leu Gln Glu Leu  Gly Lys Tyr 
    1190                 1195                 1200             


Glu Gln  Tyr Ile Lys Trp Pro  Trp Tyr Ile Trp Leu  Gly Phe Ile 
    1205                 1210                 1215             


Ala Gly  Leu Ile Ala Ile Val  Met Val Thr Ile Met  Leu Cys Cys 
    1220                 1225                 1230             


Met Thr  Ser Cys Cys Ser Cys  Leu Lys Gly Cys Cys  Ser Cys Gly 
    1235                 1240                 1245             


Ser Cys  Cys Lys Phe Asp Glu  Asp Asp Ser Glu Pro  Val Leu Lys 
    1250                 1255                 1260             


Gly Val  Lys Leu His Tyr Thr  
    1265                 1270 


<210>  125
<211>  1273
<212>  PRT
<213>  SARS-CoV-2


<220>
<221>  misc_feature
<222>  (1)..(1273)
<223>  Spike S1 & S2 ECD P.1 variant (Gamma)

<400>  125

Met Phe Val Phe Leu Val Leu Leu Pro Leu Val Ser Ser Gln Cys Val 
1               5                   10                  15      


Asn Phe Thr Asn Arg Thr Gln Leu Pro Ser Ala Tyr Thr Asn Ser Phe 
            20                  25                  30          


Thr Arg Gly Val Tyr Tyr Pro Asp Lys Val Phe Arg Ser Ser Val Leu 
        35                  40                  45              


His Ser Thr Gln Asp Leu Phe Leu Pro Phe Phe Ser Asn Val Thr Trp 
    50                  55                  60                  


Phe His Ala Ile His Val Ser Gly Thr Asn Gly Thr Lys Arg Phe Asp 
65                  70                  75                  80  


Asn Pro Val Leu Pro Phe Asn Asp Gly Val Tyr Phe Ala Ser Thr Glu 
                85                  90                  95      


Lys Ser Asn Ile Ile Arg Gly Trp Ile Phe Gly Thr Thr Leu Asp Ser 
            100                 105                 110         


Lys Thr Gln Ser Leu Leu Ile Val Asn Asn Ala Thr Asn Val Val Ile 
        115                 120                 125             


Lys Val Cys Glu Phe Gln Phe Cys Asn Tyr Pro Phe Leu Gly Val Tyr 
    130                 135                 140                 


Tyr His Lys Asn Asn Lys Ser Trp Met Glu Ser Glu Phe Arg Val Tyr 
145                 150                 155                 160 


Ser Ser Ala Asn Asn Cys Thr Phe Glu Tyr Val Ser Gln Pro Phe Leu 
                165                 170                 175     


Met Asp Leu Glu Gly Lys Gln Gly Asn Phe Lys Asn Leu Ser Glu Phe 
            180                 185                 190         


Val Phe Lys Asn Ile Asp Gly Tyr Phe Lys Ile Tyr Ser Lys His Thr 
        195                 200                 205             


Pro Ile Asn Leu Val Arg Asp Leu Pro Gln Gly Phe Ser Ala Leu Glu 
    210                 215                 220                 


Pro Leu Val Asp Leu Pro Ile Gly Ile Asn Ile Thr Arg Phe Gln Thr 
225                 230                 235                 240 


Leu Leu Ala Leu His Arg Ser Tyr Leu Thr Pro Gly Asp Ser Ser Ser 
                245                 250                 255     


Gly Trp Thr Ala Gly Ala Ala Ala Tyr Tyr Val Gly Tyr Leu Gln Pro 
            260                 265                 270         


Arg Thr Phe Leu Leu Lys Tyr Asn Glu Asn Gly Thr Ile Thr Asp Ala 
        275                 280                 285             


Val Asp Cys Ala Leu Asp Pro Leu Ser Glu Thr Lys Cys Thr Leu Lys 
    290                 295                 300                 


Ser Phe Thr Val Glu Lys Gly Ile Tyr Gln Thr Ser Asn Phe Arg Val 
305                 310                 315                 320 


Gln Pro Thr Glu Ser Ile Val Arg Phe Pro Asn Ile Thr Asn Leu Cys 
                325                 330                 335     


Pro Phe Gly Glu Val Phe Asn Ala Thr Arg Phe Ala Ser Val Tyr Ala 
            340                 345                 350         


Trp Asn Arg Lys Arg Ile Ser Asn Cys Val Ala Asp Tyr Ser Val Leu 
        355                 360                 365             


Tyr Asn Ser Ala Ser Phe Ser Thr Phe Lys Cys Tyr Gly Val Ser Pro 
    370                 375                 380                 


Thr Lys Leu Asn Asp Leu Cys Phe Thr Asn Val Tyr Ala Asp Ser Phe 
385                 390                 395                 400 


Val Ile Arg Gly Asp Glu Val Arg Gln Ile Ala Pro Gly Gln Thr Gly 
                405                 410                 415     


Thr Ile Ala Asp Tyr Asn Tyr Lys Leu Pro Asp Asp Phe Thr Gly Cys 
            420                 425                 430         


Val Ile Ala Trp Asn Ser Asn Asn Leu Asp Ser Lys Val Gly Gly Asn 
        435                 440                 445             


Tyr Asn Tyr Leu Tyr Arg Leu Phe Arg Lys Ser Asn Leu Lys Pro Phe 
    450                 455                 460                 


Glu Arg Asp Ile Ser Thr Glu Ile Tyr Gln Ala Gly Ser Thr Pro Cys 
465                 470                 475                 480 


Asn Gly Val Lys Gly Phe Asn Cys Tyr Phe Pro Leu Gln Ser Tyr Gly 
                485                 490                 495     


Phe Gln Pro Thr Tyr Gly Val Gly Tyr Gln Pro Tyr Arg Val Val Val 
            500                 505                 510         


Leu Ser Phe Glu Leu Leu His Ala Pro Ala Thr Val Cys Gly Pro Lys 
        515                 520                 525             


Lys Ser Thr Asn Leu Val Lys Asn Lys Cys Val Asn Phe Asn Phe Asn 
    530                 535                 540                 


Gly Leu Thr Gly Thr Gly Val Leu Thr Glu Ser Asn Lys Lys Phe Leu 
545                 550                 555                 560 


Pro Phe Gln Gln Phe Gly Arg Asp Ile Ala Asp Thr Thr Asp Ala Val 
                565                 570                 575     


Arg Asp Pro Gln Thr Leu Glu Ile Leu Asp Ile Thr Pro Cys Ser Phe 
            580                 585                 590         


Gly Gly Val Ser Val Ile Thr Pro Gly Thr Asn Thr Ser Asn Gln Val 
        595                 600                 605             


Ala Val Leu Tyr Gln Gly Val Asn Cys Thr Glu Val Pro Val Ala Ile 
    610                 615                 620                 


His Ala Asp Gln Leu Thr Pro Thr Trp Arg Val Tyr Ser Thr Gly Ser 
625                 630                 635                 640 


Asn Val Phe Gln Thr Arg Ala Gly Cys Leu Ile Gly Ala Glu Tyr Val 
                645                 650                 655     


Asn Asn Ser Tyr Glu Cys Asp Ile Pro Ile Gly Ala Gly Ile Cys Ala 
            660                 665                 670         


Ser Tyr Gln Thr Gln Thr Asn Ser Pro Arg Arg Ala Arg Ser Val Ala 
        675                 680                 685             


Ser Gln Ser Ile Ile Ala Tyr Thr Met Ser Leu Gly Ala Glu Asn Ser 
    690                 695                 700                 


Val Ala Tyr Ser Asn Asn Ser Ile Ala Ile Pro Thr Asn Phe Thr Ile 
705                 710                 715                 720 


Ser Val Thr Thr Glu Ile Leu Pro Val Ser Met Thr Lys Thr Ser Val 
                725                 730                 735     


Asp Cys Thr Met Tyr Ile Cys Gly Asp Ser Thr Glu Cys Ser Asn Leu 
            740                 745                 750         


Leu Leu Gln Tyr Gly Ser Phe Cys Thr Gln Leu Asn Arg Ala Leu Thr 
        755                 760                 765             


Gly Ile Ala Val Glu Gln Asp Lys Asn Thr Gln Glu Val Phe Ala Gln 
    770                 775                 780                 


Val Lys Gln Ile Tyr Lys Thr Pro Pro Ile Lys Asp Phe Gly Gly Phe 
785                 790                 795                 800 


Asn Phe Ser Gln Ile Leu Pro Asp Pro Ser Lys Pro Ser Lys Arg Ser 
                805                 810                 815     


Phe Ile Glu Asp Leu Leu Phe Asn Lys Val Thr Leu Ala Asp Ala Gly 
            820                 825                 830         


Phe Ile Lys Gln Tyr Gly Asp Cys Leu Gly Asp Ile Ala Ala Arg Asp 
        835                 840                 845             


Leu Ile Cys Ala Gln Lys Phe Asn Gly Leu Thr Val Leu Pro Pro Leu 
    850                 855                 860                 


Leu Thr Asp Glu Met Ile Ala Gln Tyr Thr Ser Ala Leu Leu Ala Gly 
865                 870                 875                 880 


Thr Ile Thr Ser Gly Trp Thr Phe Gly Ala Gly Ala Ala Leu Gln Ile 
                885                 890                 895     


Pro Phe Ala Met Gln Met Ala Tyr Arg Phe Asn Gly Ile Gly Val Thr 
            900                 905                 910         


Gln Asn Val Leu Tyr Glu Asn Gln Lys Leu Ile Ala Asn Gln Phe Asn 
        915                 920                 925             


Ser Ala Ile Gly Lys Ile Gln Asp Ser Leu Ser Ser Thr Ala Ser Ala 
    930                 935                 940                 


Leu Gly Lys Leu Gln Asp Val Val Asn Gln Asn Ala Gln Ala Leu Asn 
945                 950                 955                 960 


Thr Leu Val Lys Gln Leu Ser Ser Asn Phe Gly Ala Ile Ser Ser Val 
                965                 970                 975     


Leu Asn Asp Ile Leu Ser Arg Leu Asp Lys Val Glu Ala Glu Val Gln 
            980                 985                 990         


Ile Asp Arg Leu Ile Thr Gly Arg  Leu Gln Ser Leu Gln  Thr Tyr Val 
        995                 1000                 1005             


Thr Gln  Gln Leu Ile Arg Ala  Ala Glu Ile Arg Ala  Ser Ala Asn 
    1010                 1015                 1020             


Leu Ala  Ala Ile Lys Met Ser  Glu Cys Val Leu Gly  Gln Ser Lys 
    1025                 1030                 1035             


Arg Val  Asp Phe Cys Gly Lys  Gly Tyr His Leu Met  Ser Phe Pro 
    1040                 1045                 1050             


Gln Ser  Ala Pro His Gly Val  Val Phe Leu His Val  Thr Tyr Val 
    1055                 1060                 1065             


Pro Ala  Gln Glu Lys Asn Phe  Thr Thr Ala Pro Ala  Ile Cys His 
    1070                 1075                 1080             


Asp Gly  Lys Ala His Phe Pro  Arg Glu Gly Val Phe  Val Ser Asn 
    1085                 1090                 1095             


Gly Thr  His Trp Phe Val Thr  Gln Arg Asn Phe Tyr  Glu Pro Gln 
    1100                 1105                 1110             


Ile Ile  Thr Thr Asp Asn Thr  Phe Val Ser Gly Asn  Cys Asp Val 
    1115                 1120                 1125             


Val Ile  Gly Ile Val Asn Asn  Thr Val Tyr Asp Pro  Leu Gln Pro 
    1130                 1135                 1140             


Glu Leu  Asp Ser Phe Lys Glu  Glu Leu Asp Lys Tyr  Phe Lys Asn 
    1145                 1150                 1155             


His Thr  Ser Pro Asp Val Asp  Leu Gly Asp Ile Ser  Gly Ile Asn 
    1160                 1165                 1170             


Ala Ser  Val Val Asn Ile Gln  Lys Glu Ile Asp Arg  Leu Asn Glu 
    1175                 1180                 1185             


Val Ala  Lys Asn Leu Asn Glu  Ser Leu Ile Asp Leu  Gln Glu Leu 
    1190                 1195                 1200             


Gly Lys  Tyr Glu Gln Tyr Ile  Lys Trp Pro Trp Tyr  Ile Trp Leu 
    1205                 1210                 1215             


Gly Phe  Ile Ala Gly Leu Ile  Ala Ile Val Met Val  Thr Ile Met 
    1220                 1225                 1230             


Leu Cys  Cys Met Thr Ser Cys  Cys Ser Cys Leu Lys  Gly Cys Cys 
    1235                 1240                 1245             


Ser Cys  Gly Ser Cys Cys Lys  Phe Asp Glu Asp Asp  Ser Glu Pro 
    1250                 1255                 1260             


Val Leu  Lys Gly Val Lys Leu  His Tyr Thr 
    1265                 1270             


<210>  126
<211>  1271
<212>  PRT
<213>  SARS-CoV-2


<220>
<221>  misc_feature
<222>  (1)..(1271)
<223>  Spike S1 & S2 ECD B.1.617.2 variant (Delta)

<400>  126

Met Phe Val Phe Leu Val Leu Leu Pro Leu Val Ser Ser Gln Cys Val 
1               5                   10                  15      


Asn Leu Arg Thr Arg Thr Gln Leu Pro Pro Ala Tyr Thr Asn Ser Phe 
            20                  25                  30          


Thr Arg Gly Val Tyr Tyr Pro Asp Lys Val Phe Arg Ser Ser Val Leu 
        35                  40                  45              


His Ser Thr Gln Asp Leu Phe Leu Pro Phe Phe Ser Asn Val Thr Trp 
    50                  55                  60                  


Phe His Ala Ile His Phe Ser Gly Thr Asn Gly Thr Lys Arg Phe Asp 
65                  70                  75                  80  


Asn Pro Val Leu Pro Phe Asn Asp Gly Val Tyr Phe Ala Ser Ile Glu 
                85                  90                  95      


Lys Ser Asn Ile Ile Arg Gly Trp Ile Phe Gly Thr Thr Leu Asp Ser 
            100                 105                 110         


Lys Thr Gln Ser Leu Leu Ile Val Asn Asn Ala Thr Asn Val Val Ile 
        115                 120                 125             


Lys Val Cys Glu Phe Gln Phe Cys Asn Asp Pro Phe Leu Asp Val Tyr 
    130                 135                 140                 


Tyr His Lys Asn Asn Lys Ser Trp Met Glu Ser Gly Val Tyr Ser Ser 
145                 150                 155                 160 


Ala Asn Asn Cys Thr Phe Glu Tyr Val Ser Gln Pro Phe Leu Met Asp 
                165                 170                 175     


Leu Glu Gly Lys Gln Gly Asn Phe Lys Asn Leu Arg Glu Phe Val Phe 
            180                 185                 190         


Lys Asn Ile Asp Gly Tyr Phe Lys Ile Tyr Ser Lys His Thr Pro Ile 
        195                 200                 205             


Asn Leu Val Arg Asp Leu Pro Gln Gly Phe Ser Val Leu Glu Pro Leu 
    210                 215                 220                 


Val Asp Leu Pro Ile Gly Ile Asn Ile Thr Arg Phe Gln Thr Leu Leu 
225                 230                 235                 240 


Ala Leu His Arg Ser Tyr Leu Thr Pro Gly Asp Ser Ser Ser Gly Leu 
                245                 250                 255     


Thr Ala Gly Ala Ala Ala Tyr Tyr Val Gly Tyr Leu Gln Pro Arg Thr 
            260                 265                 270         


Phe Leu Leu Lys Tyr Asn Glu Asn Gly Thr Ile Thr Asp Ala Val Asp 
        275                 280                 285             


Cys Ala Leu Asp Pro Leu Ser Glu Thr Lys Cys Thr Leu Lys Ser Phe 
    290                 295                 300                 


Thr Val Glu Lys Gly Ile Tyr Gln Thr Ser Asn Phe Arg Val Gln Pro 
305                 310                 315                 320 


Thr Glu Ser Ile Val Arg Phe Pro Asn Ile Thr Asn Leu Cys Pro Phe 
                325                 330                 335     


Gly Glu Val Phe Asn Ala Thr Arg Phe Ala Ser Val Tyr Ala Trp Asn 
            340                 345                 350         


Arg Lys Arg Ile Ser Asn Cys Val Ala Asp Tyr Ser Val Leu Tyr Asn 
        355                 360                 365             


Ser Ala Ser Phe Ser Thr Phe Lys Cys Tyr Gly Val Ser Pro Thr Lys 
    370                 375                 380                 


Leu Asn Asp Leu Cys Phe Thr Asn Val Tyr Ala Asp Ser Phe Val Ile 
385                 390                 395                 400 


Arg Gly Asp Glu Val Arg Gln Ile Ala Pro Gly Gln Thr Gly Asn Ile 
                405                 410                 415     


Ala Asp Tyr Asn Tyr Lys Leu Pro Asp Asp Phe Thr Gly Cys Val Ile 
            420                 425                 430         


Ala Trp Asn Ser Asn Asn Leu Asp Ser Lys Val Gly Gly Asn Tyr Asn 
        435                 440                 445             


Tyr Arg Tyr Arg Leu Phe Arg Lys Ser Asn Leu Lys Pro Phe Glu Arg 
    450                 455                 460                 


Asp Ile Ser Thr Glu Ile Tyr Gln Ala Gly Ser Lys Pro Cys Asn Gly 
465                 470                 475                 480 


Val Glu Gly Phe Asn Cys Tyr Phe Pro Leu Gln Ser Tyr Gly Phe Gln 
                485                 490                 495     


Pro Thr Asn Gly Val Gly Tyr Gln Pro Tyr Arg Val Val Val Leu Ser 
            500                 505                 510         


Phe Glu Leu Leu His Ala Pro Ala Thr Val Cys Gly Pro Lys Lys Ser 
        515                 520                 525             


Thr Asn Leu Val Lys Asn Lys Cys Val Asn Phe Asn Phe Asn Gly Leu 
    530                 535                 540                 


Thr Gly Thr Gly Val Leu Thr Glu Ser Asn Lys Lys Phe Leu Pro Phe 
545                 550                 555                 560 


Gln Gln Phe Gly Arg Asp Ile Ala Asp Thr Thr Asp Ala Val Arg Asp 
                565                 570                 575     


Pro Gln Thr Leu Glu Ile Leu Asp Ile Thr Pro Cys Ser Phe Gly Gly 
            580                 585                 590         


Val Ser Val Ile Thr Pro Gly Thr Asn Thr Ser Asn Gln Val Ala Val 
        595                 600                 605             


Leu Tyr Gln Gly Val Asn Cys Thr Glu Val Pro Val Ala Ile His Ala 
    610                 615                 620                 


Asp Gln Leu Thr Pro Thr Trp Arg Val Tyr Ser Thr Gly Ser Asn Val 
625                 630                 635                 640 


Phe Gln Thr Arg Ala Gly Cys Leu Ile Gly Ala Glu His Val Asn Asn 
                645                 650                 655     


Ser Tyr Glu Cys Asp Ile Pro Ile Gly Ala Gly Ile Cys Ala Ser Tyr 
            660                 665                 670         


Gln Thr Gln Thr Asn Ser Arg Arg Arg Ala Arg Ser Val Ala Ser Gln 
        675                 680                 685             


Ser Ile Ile Ala Tyr Thr Met Ser Leu Gly Ala Glu Asn Ser Val Ala 
    690                 695                 700                 


Tyr Ser Asn Asn Ser Ile Ala Ile Pro Thr Asn Phe Thr Ile Ser Val 
705                 710                 715                 720 


Thr Thr Glu Ile Leu Pro Val Ser Met Thr Lys Thr Ser Val Asp Cys 
                725                 730                 735     


Thr Met Tyr Ile Cys Gly Asp Ser Thr Glu Cys Ser Asn Leu Leu Leu 
            740                 745                 750         


Gln Tyr Gly Ser Phe Cys Thr Gln Leu Asn Arg Ala Leu Thr Gly Ile 
        755                 760                 765             


Ala Val Glu Gln Asp Lys Asn Thr Gln Glu Val Phe Ala Gln Val Lys 
    770                 775                 780                 


Gln Ile Tyr Lys Thr Pro Pro Ile Lys Asp Phe Gly Gly Phe Asn Phe 
785                 790                 795                 800 


Ser Gln Ile Leu Pro Asp Pro Ser Lys Pro Ser Lys Arg Ser Phe Ile 
                805                 810                 815     


Glu Asp Leu Leu Phe Asn Lys Val Thr Leu Ala Asp Ala Gly Phe Ile 
            820                 825                 830         


Lys Gln Tyr Gly Asp Cys Leu Gly Asp Ile Ala Ala Arg Asp Leu Ile 
        835                 840                 845             


Cys Ala Gln Lys Phe Asn Gly Leu Thr Val Leu Pro Pro Leu Leu Thr 
    850                 855                 860                 


Asp Glu Met Ile Ala Gln Tyr Thr Ser Ala Leu Leu Ala Gly Thr Ile 
865                 870                 875                 880 


Thr Ser Gly Trp Thr Phe Gly Ala Gly Ala Ala Leu Gln Ile Pro Phe 
                885                 890                 895     


Ala Met Gln Met Ala Tyr Arg Phe Asn Gly Ile Gly Val Thr Gln Asn 
            900                 905                 910         


Val Leu Tyr Glu Asn Gln Lys Leu Ile Ala Asn Gln Phe Asn Ser Ala 
        915                 920                 925             


Ile Gly Lys Ile Gln Asp Ser Leu Ser Ser Thr Ala Ser Ala Leu Gly 
    930                 935                 940                 


Lys Leu Gln Asn Val Val Asn Gln Asn Ala Gln Ala Leu Asn Thr Leu 
945                 950                 955                 960 


Val Lys Gln Leu Ser Ser Asn Phe Gly Ala Ile Ser Ser Val Leu Asn 
                965                 970                 975     


Asp Ile Leu Ser Arg Leu Asp Lys Val Glu Ala Glu Val Gln Ile Asp 
            980                 985                 990         


Arg Leu Ile Thr Gly Arg Leu Gln  Ser Leu Gln Thr Tyr  Val Thr Gln 
        995                 1000                 1005             


Gln Leu  Ile Arg Ala Ala Glu  Ile Arg Ala Ser Ala  Asn Leu Ala 
    1010                 1015                 1020             


Ala Thr  Lys Met Ser Glu Cys  Val Leu Gly Gln Ser  Lys Arg Val 
    1025                 1030                 1035             


Asp Phe  Cys Gly Lys Gly Tyr  His Leu Met Ser Phe  Pro Gln Ser 
    1040                 1045                 1050             


Ala Pro  His Gly Val Val Phe  Leu His Val Thr Tyr  Val Pro Ala 
    1055                 1060                 1065             


Gln Glu  Lys Asn Phe Thr Thr  Ala Pro Ala Ile Cys  His Asp Gly 
    1070                 1075                 1080             


Lys Ala  His Phe Pro Arg Glu  Gly Val Phe Val Ser  Asn Gly Thr 
    1085                 1090                 1095             


His Trp  Phe Val Thr Gln Arg  Asn Phe Tyr Glu Pro  Gln Ile Ile 
    1100                 1105                 1110             


Thr Thr  Asp Asn Thr Phe Val  Ser Gly Asn Cys Asp  Val Val Ile 
    1115                 1120                 1125             


Gly Ile  Val Asn Asn Thr Val  Tyr Asp Pro Leu Gln  Pro Glu Leu 
    1130                 1135                 1140             


Asp Ser  Phe Lys Glu Glu Leu  Asp Lys Tyr Phe Lys  Asn His Thr 
    1145                 1150                 1155             


Ser Pro  Asp Val Asp Leu Gly  Asp Ile Ser Gly Ile  Asn Ala Ser 
    1160                 1165                 1170             


Val Val  Asn Ile Gln Lys Glu  Ile Asp Arg Leu Asn  Glu Val Ala 
    1175                 1180                 1185             


Lys Asn  Leu Asn Glu Ser Leu  Ile Asp Leu Gln Glu  Leu Gly Lys 
    1190                 1195                 1200             


Tyr Glu  Gln Tyr Ile Lys Trp  Pro Trp Tyr Ile Trp  Leu Gly Phe 
    1205                 1210                 1215             


Ile Ala  Gly Leu Ile Ala Ile  Val Met Val Thr Ile  Met Leu Cys 
    1220                 1225                 1230             


Cys Met  Thr Ser Cys Cys Ser  Cys Leu Lys Gly Cys  Cys Ser Cys 
    1235                 1240                 1245             


Gly Ser  Cys Cys Lys Phe Asp  Glu Asp Asp Ser Glu  Pro Val Leu 
    1250                 1255                 1260             


Lys Gly  Val Lys Leu His Tyr  Thr 
    1265                 1270     


<210>  127
<211>  1269
<212>  PRT
<213>  SARS-CoV-2


<220>
<221>  misc_feature
<222>  (1)..(1269)
<223>  Spike S1 & S2 ECD B.1.1.529 variant (Omicron)

<400>  127

Met Phe Val Phe Leu Val Leu Leu Pro Leu Val Ser Ser Gln Cys Val 
1               5                   10                  15      


Asn Leu Thr Thr Arg Thr Gln Leu Pro Pro Ala Tyr Thr Asn Ser Phe 
            20                  25                  30          


Thr Arg Gly Val Tyr Tyr Pro Asp Lys Val Phe Arg Ser Ser Val Leu 
        35                  40                  45              


His Ser Thr Gln Asp Leu Phe Leu Pro Phe Phe Ser Asn Val Thr Trp 
    50                  55                  60                  


Phe His Val Ile Ser Gly Thr Asn Gly Thr Lys Arg Phe Asp Asn Pro 
65                  70                  75                  80  


Val Leu Pro Phe Asn Asp Gly Val Tyr Phe Ala Ser Ile Glu Lys Ser 
                85                  90                  95      


Asn Ile Ile Arg Gly Trp Ile Phe Gly Thr Thr Leu Asp Ser Lys Thr 
            100                 105                 110         


Gln Ser Leu Leu Ile Val Asn Asn Ala Thr Asn Val Val Ile Lys Val 
        115                 120                 125             


Cys Glu Phe Gln Phe Cys Asn Asp Pro Phe Leu His Lys Asn Asn Lys 
    130                 135                 140                 


Ser Trp Met Glu Ser Glu Phe Arg Val Tyr Ser Ser Ala Asn Asn Cys 
145                 150                 155                 160 


Thr Phe Glu Tyr Val Ser Gln Pro Phe Leu Met Asp Leu Glu Gly Lys 
                165                 170                 175     


Gln Gly Asn Phe Lys Asn Leu Arg Glu Phe Val Phe Lys Asn Ile Asp 
            180                 185                 190         


Gly Tyr Phe Lys Ile Tyr Ser Lys His Thr Pro Ile Ile Val Arg Glu 
        195                 200                 205             


Pro Glu Asp Leu Pro Gln Gly Phe Ser Ala Leu Glu Pro Leu Val Asp 
    210                 215                 220                 


Leu Pro Ile Gly Ile Asn Ile Thr Arg Phe Gln Thr Leu Leu Ala Leu 
225                 230                 235                 240 


His Arg Ser Tyr Leu Thr Pro Gly Asp Ser Ser Ser Gly Trp Thr Ala 
                245                 250                 255     


Gly Ala Ala Ala Tyr Tyr Val Gly Tyr Leu Gln Pro Arg Thr Phe Leu 
            260                 265                 270         


Leu Lys Tyr Asn Glu Asn Gly Thr Ile Thr Asp Ala Val Asp Cys Ala 
        275                 280                 285             


Leu Asp Pro Leu Ser Glu Thr Lys Cys Thr Leu Lys Ser Phe Thr Val 
    290                 295                 300                 


Glu Lys Gly Ile Tyr Gln Thr Ser Asn Phe Arg Val Gln Pro Thr Glu 
305                 310                 315                 320 


Ser Ile Val Arg Phe Pro Asn Ile Thr Asn Leu Cys Pro Phe Asp Glu 
                325                 330                 335     


Val Phe Asn Ala Thr Arg Phe Ala Ser Val Tyr Ala Trp Asn Arg Lys 
            340                 345                 350         


Arg Ile Ser Asn Cys Val Ala Asp Tyr Ser Val Leu Tyr Asn Leu Ala 
        355                 360                 365             


Pro Phe Phe Thr Phe Lys Cys Tyr Gly Val Ser Pro Thr Lys Leu Asn 
    370                 375                 380                 


Asp Leu Cys Phe Thr Asn Val Tyr Ala Asp Ser Phe Val Ile Arg Gly 
385                 390                 395                 400 


Asp Glu Val Arg Gln Ile Ala Pro Gly Gln Thr Gly Asn Ile Ala Asp 
                405                 410                 415     


Tyr Asn Tyr Lys Leu Pro Asp Asp Phe Thr Gly Cys Val Ile Ala Trp 
            420                 425                 430         


Asn Ser Asn Lys Leu Asp Ser Lys Val Ser Gly Asn Tyr Asn Tyr Leu 
        435                 440                 445             


Tyr Arg Leu Phe Arg Lys Ser Asn Leu Lys Pro Phe Glu Arg Asp Ile 
    450                 455                 460                 


Ser Thr Glu Ile Tyr Gln Ala Gly Asn Lys Pro Cys Asn Gly Val Ala 
465                 470                 475                 480 


Gly Phe Asn Cys Tyr Phe Pro Leu Arg Ser Tyr Ser Phe Arg Pro Thr 
                485                 490                 495     


Tyr Gly Val Gly His Gln Pro Tyr Arg Val Val Val Leu Ser Phe Glu 
            500                 505                 510         


Leu Leu His Ala Pro Ala Thr Val Cys Gly Pro Lys Lys Ser Thr Asn 
        515                 520                 525             


Leu Val Lys Asn Lys Cys Val Asn Phe Asn Phe Asn Gly Leu Lys Gly 
    530                 535                 540                 


Thr Gly Val Leu Thr Glu Ser Asn Lys Lys Phe Leu Pro Phe Gln Gln 
545                 550                 555                 560 


Phe Gly Arg Asp Ile Ala Asp Thr Thr Asp Ala Val Arg Asp Pro Gln 
                565                 570                 575     


Thr Leu Glu Ile Leu Asp Ile Thr Pro Cys Ser Phe Gly Gly Val Ser 
            580                 585                 590         


Val Ile Thr Pro Gly Thr Asn Thr Ser Asn Gln Val Ala Val Leu Tyr 
        595                 600                 605             


Gln Gly Val Asn Cys Thr Glu Val Pro Val Ala Ile His Ala Asp Gln 
    610                 615                 620                 


Leu Thr Pro Thr Trp Arg Val Tyr Ser Thr Gly Ser Asn Val Phe Gln 
625                 630                 635                 640 


Thr Arg Ala Gly Cys Leu Ile Gly Ala Glu Tyr Val Asn Asn Ser Tyr 
                645                 650                 655     


Glu Cys Asp Ile Pro Ile Gly Ala Gly Ile Cys Ala Ser Tyr Gln Thr 
            660                 665                 670         


Gln Thr Lys Ser His Arg Arg Ala Arg Ser Val Ala Ser Gln Ser Ile 
        675                 680                 685             


Ile Ala Tyr Thr Met Ser Leu Gly Ala Glu Asn Ser Val Ala Tyr Ser 
    690                 695                 700                 


Asn Asn Ser Ile Ala Ile Pro Thr Asn Phe Thr Ile Ser Val Thr Thr 
705                 710                 715                 720 


Glu Ile Leu Pro Val Ser Met Thr Lys Thr Ser Val Asp Cys Thr Met 
                725                 730                 735     


Tyr Ile Cys Gly Asp Ser Thr Glu Cys Ser Asn Leu Leu Leu Gln Tyr 
            740                 745                 750         


Gly Ser Phe Cys Thr Gln Leu Lys Arg Ala Leu Thr Gly Ile Ala Val 
        755                 760                 765             


Glu Gln Asp Lys Asn Thr Gln Glu Val Phe Ala Gln Val Lys Gln Ile 
    770                 775                 780                 


Tyr Lys Thr Pro Pro Ile Lys Tyr Phe Gly Gly Phe Asn Phe Ser Gln 
785                 790                 795                 800 


Ile Leu Pro Asp Pro Ser Lys Pro Ser Lys Arg Ser Phe Ile Glu Asp 
                805                 810                 815     


Leu Leu Phe Asn Lys Val Thr Leu Ala Asp Ala Gly Phe Ile Lys Gln 
            820                 825                 830         


Tyr Gly Asp Cys Leu Gly Asp Ile Ala Ala Arg Asp Leu Ile Cys Ala 
        835                 840                 845             


Gln Lys Phe Lys Gly Leu Thr Val Leu Pro Pro Leu Leu Thr Asp Glu 
    850                 855                 860                 


Met Ile Ala Gln Tyr Thr Ser Ala Leu Leu Ala Gly Thr Ile Thr Ser 
865                 870                 875                 880 


Gly Trp Thr Phe Gly Ala Gly Ala Ala Leu Gln Ile Pro Phe Ala Met 
                885                 890                 895     


Gln Met Ala Tyr Arg Phe Asn Gly Ile Gly Val Thr Gln Asn Val Leu 
            900                 905                 910         


Tyr Glu Asn Gln Lys Leu Ile Ala Asn Gln Phe Asn Ser Ala Ile Gly 
        915                 920                 925             


Lys Ile Gln Asp Ser Leu Ser Ser Thr Ala Ser Ala Leu Gly Lys Leu 
    930                 935                 940                 


Gln Asp Val Val Asn His Asn Ala Gln Ala Leu Asn Thr Leu Val Lys 
945                 950                 955                 960 


Gln Leu Ser Ser Lys Phe Gly Ala Ile Ser Ser Val Leu Asn Asp Ile 
                965                 970                 975     


Phe Ser Arg Leu Asp Lys Val Glu Ala Glu Val Gln Ile Asp Arg Leu 
            980                 985                 990         


Ile Thr Gly Arg Leu Gln Ser Leu  Gln Thr Tyr Val Thr  Gln Gln Leu 
        995                 1000                 1005             


Ile Arg  Ala Ala Glu Ile Arg  Ala Ser Ala Asn Leu  Ala Ala Thr 
    1010                 1015                 1020             


Lys Met  Ser Glu Cys Val Leu  Gly Gln Ser Lys Arg  Val Asp Phe 
    1025                 1030                 1035             


Cys Gly  Lys Gly Tyr His Leu  Met Ser Phe Pro Gln  Ser Ala Pro 
    1040                 1045                 1050             


His Gly  Val Val Phe Leu His  Val Thr Tyr Val Pro  Ala Gln Glu 
    1055                 1060                 1065             


Lys Asn  Phe Thr Thr Ala Pro  Ala Ile Cys His Asp  Gly Lys Ala 
    1070                 1075                 1080             


His Phe  Pro Arg Glu Gly Val  Phe Val Ser Asn Gly  Thr His Trp 
    1085                 1090                 1095             


Phe Val  Thr Gln Arg Asn Phe  Tyr Glu Pro Gln Ile  Ile Thr Thr 
    1100                 1105                 1110             


Asp Asn  Thr Phe Val Ser Gly  Asn Cys Asp Val Val  Ile Gly Ile 
    1115                 1120                 1125             


Val Asn  Asn Thr Val Tyr Asp  Pro Leu Gln Pro Glu  Leu Asp Ser 
    1130                 1135                 1140             


Phe Lys  Glu Glu Leu Asp Lys  Tyr Phe Lys Asn His  Thr Ser Pro 
    1145                 1150                 1155             


Asp Val  Asp Leu Gly Asp Ile  Ser Gly Ile Asn Ala  Ser Val Val 
    1160                 1165                 1170             


Asn Ile  Gln Lys Glu Ile Asp  Arg Leu Asn Glu Val  Ala Lys Asn 
    1175                 1180                 1185             


Leu Asn  Glu Ser Leu Ile Asp  Leu Gln Glu Leu Gly  Lys Tyr Glu 
    1190                 1195                 1200             


Gln Tyr  Ile Lys Trp Pro Trp  Tyr Ile Trp Leu Gly  Phe Ile Ala 
    1205                 1210                 1215             


Gly Leu  Ile Ala Ile Val Met  Val Thr Ile Met Leu  Cys Cys Met 
    1220                 1225                 1230             


Thr Ser  Cys Cys Ser Cys Leu  Lys Gly Cys Cys Ser  Cys Gly Ser 
    1235                 1240                 1245             


Cys Cys  Lys Phe Asp Glu Asp  Asp Ser Glu Pro Val  Leu Lys Gly 
    1250                 1255                 1260             


Val Lys  Leu His Tyr Thr 
    1265                 


<210>  128
<211>  29
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Synthetic: OH-26874-29_181


<220>
<221>  misc_feature
<222>  (1)..(29)
<223>  Every n is a C-5 modified pyrimidine such as Tyr-dU,  PP-dC, 
       Bn-dC,  Nap-dC,  2Nap-dC,  Tyr-dC,  PBn-dC,  DPP-dC,  and DCPE-dC

<220>
<221>  misc_feature
<222>  (1)..(29)
<223>  See specification as filed for detailed description of 
       substitutions and preferred embodiments

<400>  128
ggganannan gngnnngann gnnnggang                                         29


<210>  129
<211>  29
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Synthetic: OH-26874-29_182


<220>
<221>  misc_feature
<222>  (1)..(29)
<223>  Every n is a C-5 modified pyrimidine such as Tyr-dU,  PP-dC, 
       Bn-dC,  Nap-dC,  2Nap-dC,  Tyr-dC,  PBn-dC,  DPP-dC,  and DCPE-dC

<220>
<221>  misc_feature
<222>  (1)..(29)
<223>  See specification as filed for detailed description of 
       substitutions and preferred embodiments

<400>  129
ggganannan gngnnngann gnnnggang                                         29


<210>  130
<211>  29
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Synthetic: OH-26874-29_183


<220>
<221>  misc_feature
<222>  (1)..(29)
<223>  Every n is a C-5 modified pyrimidine such as Tyr-dU,  PP-dC, 
       Bn-dC,  Nap-dC,  2Nap-dC,  Tyr-dC,  PBn-dC,  DPP-dC,  and DCPE-dC

<220>
<221>  misc_feature
<222>  (1)..(29)
<223>  See specification as filed for detailed description of 
       substitutions and preferred embodiments

<400>  130
ggganannan gngnnngann gnnnggang                                         29


<210>  131
<211>  29
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Synthetic: OH-26874-29_184


<220>
<221>  misc_feature
<222>  (1)..(29)
<223>  Every n is a C-5 modified pyrimidine such as Tyr-dU,  PP-dC, 
       Bn-dC,  Nap-dC,  2Nap-dC,  Tyr-dC,  PBn-dC,  DPP-dC,  and DCPE-dC

<220>
<221>  misc_feature
<222>  (1)..(29)
<223>  See specification as filed for detailed description of 
       substitutions and preferred embodiments

<400>  131
ggganannan gngnnngann gnnnggang                                         29


<210>  132
<211>  29
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Synthetic: OH-26874-29_185


<220>
<221>  misc_feature
<222>  (1)..(29)
<223>  Every n is a C-5 modified pyrimidine such as Tyr-dU,  PP-dC, 
       Bn-dC,  Nap-dC,  2Nap-dC,  Tyr-dC,  PBn-dC,  DPP-dC,  and DCPE-dC

<220>
<221>  misc_feature
<222>  (1)..(29)
<223>  See specification as filed for detailed description of 
       substitutions and preferred embodiments

<400>  132
ggganannan gngnnngann gnnnggang                                         29


<210>  133
<211>  29
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Synthetic: OH-26874-29_186


<220>
<221>  misc_feature
<222>  (1)..(29)
<223>  Every n is a C-5 modified pyrimidine such as Tyr-dU,  PP-dC, 
       Bn-dC,  Nap-dC,  2Nap-dC,  Tyr-dC,  PBn-dC,  DPP-dC,  and DCPE-dC

<220>
<221>  misc_feature
<222>  (1)..(29)
<223>  See specification as filed for detailed description of 
       substitutions and preferred embodiments

<400>  133
ggganannan gngnnngann gnnnggang                                         29


<210>  134
<211>  29
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Synthetic: OH-26874-29_187


<220>
<221>  misc_feature
<222>  (1)..(29)
<223>  Every n is a C-5 modified pyrimidine such as Tyr-dU,  PP-dC, 
       Bn-dC,  Nap-dC,  2Nap-dC,  Tyr-dC,  PBn-dC,  DPP-dC,  and DCPE-dC

<220>
<221>  misc_feature
<222>  (1)..(29)
<223>  See specification as filed for detailed description of 
       substitutions and preferred embodiments

<400>  134
ggganannan gngnnngann gnnnggang                                         29


<210>  135
<211>  29
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Synthetic: OH-26874-29_188


<220>
<221>  misc_feature
<222>  (1)..(29)
<223>  Every n is a C-5 modified pyrimidine such as Tyr-dU,  PP-dC, 
       Bn-dC,  Nap-dC,  2Nap-dC,  Tyr-dC,  PBn-dC,  DPP-dC,  and DCPE-dC

<220>
<221>  misc_feature
<222>  (1)..(29)
<223>  See specification as filed for detailed description of 
       substitutions and preferred embodiments

<400>  135
ggganannan gngnnngann gnnnggang                                         29


<210>  136
<211>  29
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Synthetic: OH-26874-29_189


<220>
<221>  misc_feature
<222>  (1)..(29)
<223>  Every n is a C-5 modified pyrimidine such as Tyr-dU,  PP-dC, 
       Bn-dC,  Nap-dC,  2Nap-dC,  Tyr-dC,  PBn-dC,  DPP-dC,  and DCPE-dC

<220>
<221>  misc_feature
<222>  (1)..(29)
<223>  See specification as filed for detailed description of 
       substitutions and preferred embodiments

<400>  136
ggganannan gngnnngann gnnnggang                                         29


<210>  137
<211>  29
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Synthetic: OH-26874-29_190


<220>
<221>  misc_feature
<222>  (1)..(29)
<223>  Every n is a C-5 modified pyrimidine such as Tyr-dU,  PP-dC, 
       Bn-dC,  Nap-dC,  2Nap-dC,  Tyr-dC,  PBn-dC,  DPP-dC,  and DCPE-dC

<220>
<221>  misc_feature
<222>  (1)..(29)
<223>  See specification as filed for detailed description of 
       substitutions and preferred embodiments

<400>  137
ggganarnan gngnnngann gnnnggang                                         29


<210>  138
<211>  29
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Synthetic: OH-26874-29_191


<220>
<221>  misc_feature
<222>  (1)..(29)
<223>  Every n is a C-5 modified pyrimidine such as Tyr-dU,  PP-dC, 
       Bn-dC,  Nap-dC,  2Nap-dC,  Tyr-dC,  PBn-dC,  DPP-dC,  and DCPE-dC

<220>
<221>  misc_feature
<222>  (1)..(29)
<223>  See specification as filed for detailed description of 
       substitutions and preferred embodiments

<400>  138
ggganannan grgnnngann gnnnggang                                         29


<210>  139
<211>  29
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Synthetic: OH-26874-29_192


<220>
<221>  misc_feature
<222>  (1)..(29)
<223>  Every n is a C-5 modified pyrimidine such as Tyr-dU,  PP-dC, 
       Bn-dC,  Nap-dC,  2Nap-dC,  Tyr-dC,  PBn-dC,  DPP-dC,  and DCPE-dC

<220>
<221>  misc_feature
<222>  (1)..(29)
<223>  See specification as filed for detailed description of 
       substitutions and preferred embodiments

<400>  139
ggganannan gngnrngann gnnnggang                                         29


<210>  140
<211>  29
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Synthetic: OH-26874-29_193


<220>
<221>  misc_feature
<222>  (1)..(29)
<223>  Every n is a C-5 modified pyrimidine such as Tyr-dU,  PP-dC, 
       Bn-dC,  Nap-dC,  2Nap-dC,  Tyr-dC,  PBn-dC,  DPP-dC,  and DCPE-dC

<220>
<221>  misc_feature
<222>  (1)..(29)
<223>  See specification as filed for detailed description of 
       substitutions and preferred embodiments

<400>  140
ggganannan gngnnrgann gnnnggang                                         29


<210>  141
<211>  29
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Synthetic: OH-26874-29_194


<220>
<221>  misc_feature
<222>  (1)..(29)
<223>  Every n is a C-5 modified pyrimidine such as Tyr-dU,  PP-dC, 
       Bn-dC,  Nap-dC,  2Nap-dC,  Tyr-dC,  PBn-dC,  DPP-dC,  and DCPE-dC

<220>
<221>  misc_feature
<222>  (1)..(29)
<223>  See specification as filed for detailed description of 
       substitutions and preferred embodiments

<400>  141
ggganannan gngnnngarn gnnnggang                                         29


<210>  142
<211>  29
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Synthetic: OH-26874-29_195


<220>
<221>  misc_feature
<222>  (1)..(29)
<223>  Every n is a C-5 modified pyrimidine such as Tyr-dU,  PP-dC, 
       Bn-dC,  Nap-dC,  2Nap-dC,  Tyr-dC,  PBn-dC,  DPP-dC,  and DCPE-dC

<220>
<221>  misc_feature
<222>  (1)..(29)
<223>  See specification as filed for detailed description of 
       substitutions and preferred embodiments

<400>  142
ggganannan gngnnnganr gnnnggang                                         29


<210>  143
<211>  29
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Synthetic: OH-26874-29_196


<220>
<221>  misc_feature
<222>  (1)..(29)
<223>  Every n is a C-5 modified pyrimidine such as Tyr-dU,  PP-dC, 
       Bn-dC,  Nap-dC,  2Nap-dC,  Tyr-dC,  PBn-dC,  DPP-dC,  and DCPE-dC

<220>
<221>  misc_feature
<222>  (1)..(29)
<223>  See specification as filed for detailed description of 
       substitutions and preferred embodiments

<400>  143
ggganannan gngnnngann grnnggang                                         29


<210>  144
<211>  29
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Synthetic: OH-26874-29_197


<220>
<221>  misc_feature
<222>  (1)..(29)
<223>  Every n is a C-5 modified pyrimidine such as Tyr-dU,  PP-dC, 
       Bn-dC,  Nap-dC,  2Nap-dC,  Tyr-dC,  PBn-dC,  DPP-dC,  and DCPE-dC

<220>
<221>  misc_feature
<222>  (1)..(29)
<223>  See specification as filed for detailed description of 
       substitutions and preferred embodiments

<400>  144
ggganannan gngnnngann gnnrggang                                         29


<210>  145
<211>  29
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Synthetic: OH-26874-29_198


<220>
<221>  misc_feature
<222>  (1)..(29)
<223>  Every n is a C-5 modified pyrimidine such as Tyr-dU,  PP-dC, 
       Bn-dC,  Nap-dC,  2Nap-dC,  Tyr-dC,  PBn-dC,  DPP-dC,  and DCPE-dC

<220>
<221>  misc_feature
<222>  (1)..(29)
<223>  See specification as filed for detailed description of 
       substitutions and preferred embodiments

<400>  145
ggganannan gngnnngann gnnnggarg                                         29


<210>  146
<211>  29
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Synthetic: OH-26874-29_199


<220>
<221>  misc_feature
<222>  (1)..(29)
<223>  Every n is a C-5 modified pyrimidine such as Tyr-dU,  PP-dC, 
       Bn-dC,  Nap-dC,  2Nap-dC,  Tyr-dC,  PBn-dC,  DPP-dC,  and DCPE-dC

<220>
<221>  misc_feature
<222>  (1)..(29)
<223>  See specification as filed for detailed description of 
       substitutions and preferred embodiments

<400>  146
ggganannan gngnnngann gnnnggang                                         29


<210>  147
<211>  29
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Synthetic: OH-26874-29_200


<220>
<221>  misc_feature
<222>  (1)..(29)
<223>  Every n is a C-5 modified pyrimidine such as Tyr-dU,  PP-dC, 
       Bn-dC,  Nap-dC,  2Nap-dC,  Tyr-dC,  PBn-dC,  DPP-dC,  and DCPE-dC

<220>
<221>  misc_feature
<222>  (1)..(29)
<223>  See specification as filed for detailed description of 
       substitutions and preferred embodiments

<400>  147
ggganannan gngnnngann gnnnggang                                         29


<210>  148
<211>  29
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Synthetic: OH-26874-29_201


<220>
<221>  misc_feature
<222>  (1)..(29)
<223>  Every n is a C-5 modified pyrimidine such as Tyr-dU,  PP-dC, 
       Bn-dC,  Nap-dC,  2Nap-dC,  Tyr-dC,  PBn-dC,  DPP-dC,  and DCPE-dC

<220>
<221>  misc_feature
<222>  (1)..(29)
<223>  See specification as filed for detailed description of 
       substitutions and preferred embodiments

<400>  148
ggganannan gngnnngann gnnnggang                                         29


<210>  149
<211>  29
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Synthetic: OH-26874-29_202


<220>
<221>  misc_feature
<222>  (1)..(29)
<223>  Every n is a C-5 modified pyrimidine such as Tyr-dU,  PP-dC, 
       Bn-dC,  Nap-dC,  2Nap-dC,  Tyr-dC,  PBn-dC,  DPP-dC,  and DCPE-dC

<220>
<221>  misc_feature
<222>  (1)..(29)
<223>  See specification as filed for detailed description of 
       substitutions and preferred embodiments

<400>  149
ggganannan gngnnngann gnnnggang                                         29


<210>  150
<211>  29
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Synthetic: OH-26874-29_203


<220>
<221>  misc_feature
<222>  (1)..(29)
<223>  Every n is a C-5 modified pyrimidine such as Tyr-dU,  PP-dC, 
       Bn-dC,  Nap-dC,  2Nap-dC,  Tyr-dC,  PBn-dC,  DPP-dC,  and DCPE-dC

<220>
<221>  misc_feature
<222>  (1)..(29)
<223>  See specification as filed for detailed description of 
       substitutions and preferred embodiments

<400>  150
ggganannan gngnnngann gnnnggang                                         29


<210>  151
<211>  29
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Synthetic: OH-26874-29_204


<220>
<221>  misc_feature
<222>  (1)..(29)
<223>  Every n is a C-5 modified pyrimidine such as Tyr-dU,  PP-dC, 
       Bn-dC,  Nap-dC,  2Nap-dC,  Tyr-dC,  PBn-dC,  DPP-dC,  and DCPE-dC

<220>
<221>  misc_feature
<222>  (1)..(29)
<223>  See specification as filed for detailed description of 
       substitutions and preferred embodiments

<400>  151
ggganannan gngnnngann gnnnggang                                         29


<210>  152
<211>  29
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Synthetic: OH-26874-29_205


<220>
<221>  misc_feature
<222>  (1)..(29)
<223>  Every n is a C-5 modified pyrimidine such as Tyr-dU,  PP-dC, 
       Bn-dC,  Nap-dC,  2Nap-dC,  Tyr-dC,  PBn-dC,  DPP-dC,  and DCPE-dC

<220>
<221>  misc_feature
<222>  (1)..(29)
<223>  See specification as filed for detailed description of 
       substitutions and preferred embodiments

<400>  152
ggganannan gngnnngann gnnnggang                                         29


<210>  153
<211>  29
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Synthetic: OH-26874-29_206


<220>
<221>  misc_feature
<222>  (1)..(29)
<223>  Every n is a C-5 modified pyrimidine such as Tyr-dU,  PP-dC, 
       Bn-dC,  Nap-dC,  2Nap-dC,  Tyr-dC,  PBn-dC,  DPP-dC,  and DCPE-dC

<220>
<221>  misc_feature
<222>  (1)..(29)
<223>  See specification as filed for detailed description of 
       substitutions and preferred embodiments

<400>  153
ggganannan gngnnngann gnnnggang                                         29


<210>  154
<211>  29
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Synthetic: OH-26874-29_207


<220>
<221>  misc_feature
<222>  (1)..(29)
<223>  Every n is a C-5 modified pyrimidine such as Tyr-dU,  PP-dC, 
       Bn-dC,  Nap-dC,  2Nap-dC,  Tyr-dC,  PBn-dC,  DPP-dC,  and DCPE-dC

<220>
<221>  misc_feature
<222>  (1)..(29)
<223>  See specification as filed for detailed description of 
       substitutions and preferred embodiments

<400>  154
ggganannan gngnnngann gnnnggang                                         29


<210>  155
<211>  29
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Synthetic: OH-26874-29_208


<220>
<221>  misc_feature
<222>  (1)..(29)
<223>  Every n is a C-5 modified pyrimidine such as Tyr-dU,  PP-dC, 
       Bn-dC,  Nap-dC,  2Nap-dC,  Tyr-dC,  PBn-dC,  DPP-dC,  and DCPE-dC

<220>
<221>  misc_feature
<222>  (1)..(29)
<223>  See specification as filed for detailed description of 
       substitutions and preferred embodiments

<400>  155
ggganannan gngnnngann gnnnggang                                         29


<210>  156
<211>  29
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Synthetic: OH-26874-29_209


<220>
<221>  misc_feature
<222>  (1)..(29)
<223>  Every n is a C-5 modified pyrimidine such as Tyr-dU,  PP-dC, 
       Bn-dC,  Nap-dC,  2Nap-dC,  Tyr-dC,  PBn-dC,  DPP-dC,  and DCPE-dC

<220>
<221>  misc_feature
<222>  (1)..(29)
<223>  See specification as filed for detailed description of 
       substitutions and preferred embodiments

<400>  156
ggganannan gngnnngann gnnnggang                                         29


<210>  157
<211>  29
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Synthetic: OH-26874-29_210


<220>
<221>  misc_feature
<222>  (1)..(29)
<223>  Every n is a C-5 modified pyrimidine such as Tyr-dU,  PP-dC, 
       Bn-dC,  Nap-dC,  2Nap-dC,  Tyr-dC,  PBn-dC,  DPP-dC,  and DCPE-dC

<220>
<221>  misc_feature
<222>  (1)..(29)
<223>  See specification as filed for detailed description of 
       substitutions and preferred embodiments

<400>  157
ggganannan gngnnngann gnnnggang                                         29


<210>  158
<211>  29
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Synthetic: OH-26874-29_211


<220>
<221>  misc_feature
<222>  (1)..(29)
<223>  Every n is a C-5 modified pyrimidine such as Tyr-dU,  PP-dC, 
       Bn-dC,  Nap-dC,  2Nap-dC,  Tyr-dC,  PBn-dC,  DPP-dC,  and DCPE-dC

<220>
<221>  misc_feature
<222>  (1)..(29)
<223>  See specification as filed for detailed description of 
       substitutions and preferred embodiments

<400>  158
ggganannan gngnnngann gnnnggang                                         29


<210>  159
<211>  29
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Synthetic: OH-26874-29_212


<220>
<221>  misc_feature
<222>  (1)..(29)
<223>  Every n is a C-5 modified pyrimidine such as Tyr-dU,  PP-dC, 
       Bn-dC,  Nap-dC,  2Nap-dC,  Tyr-dC,  PBn-dC,  DPP-dC,  and DCPE-dC

<220>
<221>  misc_feature
<222>  (1)..(29)
<223>  See specification as filed for detailed description of 
       substitutions and preferred embodiments

<400>  159
ggganannan gngnnngann gnnnggang                                         29


<210>  160
<211>  29
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Synthetic: OH-26874-29_213


<220>
<221>  misc_feature
<222>  (1)..(29)
<223>  Every n is a C-5 modified pyrimidine such as Tyr-dU,  PP-dC, 
       Bn-dC,  Nap-dC,  2Nap-dC,  Tyr-dC,  PBn-dC,  DPP-dC,  and DCPE-dC

<220>
<221>  misc_feature
<222>  (1)..(29)
<223>  See specification as filed for detailed description of 
       substitutions and preferred embodiments

<400>  160
ggganannan gngnnngann gnnnggang                                         29


<210>  161
<211>  29
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Synthetic: OH-26874-29_214


<220>
<221>  misc_feature
<222>  (1)..(29)
<223>  Every n is a C-5 modified pyrimidine such as Tyr-dU,  PP-dC, 
       Bn-dC,  Nap-dC,  2Nap-dC,  Tyr-dC,  PBn-dC,  DPP-dC,  and DCPE-dC

<220>
<221>  misc_feature
<222>  (1)..(29)
<223>  See specification as filed for detailed description of 
       substitutions and preferred embodiments

<400>  161
ggganannan gngnnngann gnnnggang                                         29


<210>  162
<211>  29
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Synthetic: OH-26874-29_215


<220>
<221>  misc_feature
<222>  (1)..(29)
<223>  Every n is a C-5 modified pyrimidine such as Tyr-dU,  PP-dC, 
       Bn-dC,  Nap-dC,  2Nap-dC,  Tyr-dC,  PBn-dC,  DPP-dC,  and DCPE-dC

<220>
<221>  misc_feature
<222>  (1)..(29)
<223>  See specification as filed for detailed description of 
       substitutions and preferred embodiments

<400>  162
ggganannan gngnnngann gnnnggang                                         29


<210>  163
<211>  29
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Synthetic: OH-26874-29_216


<220>
<221>  misc_feature
<222>  (1)..(29)
<223>  Every n is a C-5 modified pyrimidine such as Tyr-dU,  PP-dC, 
       Bn-dC,  Nap-dC,  2Nap-dC,  Tyr-dC,  PBn-dC,  DPP-dC,  and DCPE-dC

<220>
<221>  misc_feature
<222>  (1)..(29)
<223>  See specification as filed for detailed description of 
       substitutions and preferred embodiments

<400>  163
ggganannan gngnnngann gnnnggang                                         29


<210>  164
<211>  29
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Synthetic: OH-26874-29_314


<220>
<221>  misc_feature
<222>  (1)..(29)
<223>  Every n is a C-5 modified pyrimidine such as Tyr-dU,  PP-dC, 
       Bn-dC,  Nap-dC,  2Nap-dC,  Tyr-dC,  PBn-dC,  DPP-dC,  and DCPE-dC

<220>
<221>  misc_feature
<222>  (1)..(29)
<223>  See specification as filed for detailed description of 
       substitutions and preferred embodiments

<400>  164
ggganannan gngnnngann gnnnggang                                         29


<210>  165
<211>  29
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Synthetic: OH-26874-29_315


<220>
<221>  misc_feature
<222>  (1)..(29)
<223>  Every n is a C-5 modified pyrimidine such as Tyr-dU,  PP-dC, 
       Bn-dC,  Nap-dC,  2Nap-dC,  Tyr-dC,  PBn-dC,  DPP-dC,  and DCPE-dC

<220>
<221>  misc_feature
<222>  (1)..(29)
<223>  See specification as filed for detailed description of 
       substitutions and preferred embodiments

<400>  165
ggganannan gngnnngann gnnnggang                                         29


<210>  166
<211>  29
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Synthetic: OH-26874-29_316


<220>
<221>  misc_feature
<222>  (1)..(29)
<223>  Every n is a C-5 modified pyrimidine such as Tyr-dU,  PP-dC, 
       Bn-dC,  Nap-dC,  2Nap-dC,  Tyr-dC,  PBn-dC,  DPP-dC,  and DCPE-dC

<220>
<221>  misc_feature
<222>  (1)..(29)
<223>  See specification as filed for detailed description of 
       substitutions and preferred embodiments

<400>  166
ggganannan gngnnngann gnnnggang                                         29


<210>  167
<211>  29
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Synthetic: OH-26874-29_317


<220>
<221>  misc_feature
<222>  (1)..(29)
<223>  Every n is a C-5 modified pyrimidine such as Tyr-dU,  PP-dC, 
       Bn-dC,  Nap-dC,  2Nap-dC,  Tyr-dC,  PBn-dC,  DPP-dC,  and DCPE-dC

<220>
<221>  misc_feature
<222>  (1)..(29)
<223>  See specification as filed for detailed description of 
       substitutions and preferred embodiments

<400>  167
ggganannan gngnnngann gnnnggang                                         29


<210>  168
<211>  29
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Synthetic: OH-26874-29_318


<220>
<221>  misc_feature
<222>  (1)..(29)
<223>  Every n is a C-5 modified pyrimidine such as Tyr-dU,  PP-dC, 
       Bn-dC,  Nap-dC,  2Nap-dC,  Tyr-dC,  PBn-dC,  DPP-dC,  and DCPE-dC

<220>
<221>  misc_feature
<222>  (1)..(29)
<223>  See specification as filed for detailed description of 
       substitutions and preferred embodiments

<400>  168
ggganannan gngnnngann gnnnggang                                         29


<210>  169
<211>  30
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Synthetic: OH-26874-29_319


<220>
<221>  misc_feature
<222>  (1)..(30)
<223>  Every n is a C-5 modified pyrimidine such as Tyr-dU,  PP-dC, 
       Bn-dC,  Nap-dC,  2Nap-dC,  Tyr-dC,  PBn-dC,  DPP-dC,  and DCPE-dC

<220>
<221>  misc_feature
<222>  (1)..(30)
<223>  See specification as filed for detailed description of 
       substitutions and preferred embodiments

<400>  169
ggganannan gngnnngann ngnnnggang                                        30


<210>  170
<211>  29
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Synthetic: OH-26874-29_320


<220>
<221>  misc_feature
<222>  (1)..(29)
<223>  Every n is a C-5 modified pyrimidine such as Tyr-dU,  PP-dC, 
       Bn-dC,  Nap-dC,  2Nap-dC,  Tyr-dC,  PBn-dC,  DPP-dC,  and DCPE-dC

<220>
<221>  misc_feature
<222>  (1)..(29)
<223>  See specification as filed for detailed description of 
       substitutions and preferred embodiments

<400>  170
ggganannan gngnnngann gnnnggang                                         29


<210>  171
<211>  29
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Synthetic: OH-26874-29_321


<220>
<221>  misc_feature
<222>  (1)..(29)
<223>  Every n is a C-5 modified pyrimidine such as Tyr-dU,  PP-dC, 
       Bn-dC,  Nap-dC,  2Nap-dC,  Tyr-dC,  PBn-dC,  DPP-dC,  and DCPE-dC

<220>
<221>  misc_feature
<222>  (1)..(29)
<223>  See specification as filed for detailed description of 
       substitutions and preferred embodiments

<400>  171
ggganannan gngnnngann gnnnggang                                         29


<210>  172
<211>  29
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Synthetic: OH-26874-29_322


<220>
<221>  misc_feature
<222>  (1)..(29)
<223>  Every n is a C-5 modified pyrimidine such as Tyr-dU,  PP-dC, 
       Bn-dC,  Nap-dC,  2Nap-dC,  Tyr-dC,  PBn-dC,  DPP-dC,  and DCPE-dC

<220>
<221>  misc_feature
<222>  (1)..(29)
<223>  See specification as filed for detailed description of 
       substitutions and preferred embodiments

<400>  172
ggganannan gngnnngann gnnnggang                                         29


<210>  173
<211>  29
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Synthetic: OH-26874-29_323


<220>
<221>  misc_feature
<222>  (1)..(29)
<223>  Every n is a C-5 modified pyrimidine such as Tyr-dU,  PP-dC, 
       Bn-dC,  Nap-dC,  2Nap-dC,  Tyr-dC,  PBn-dC,  DPP-dC,  and DCPE-dC

<220>
<221>  misc_feature
<222>  (1)..(29)
<223>  See specification as filed for detailed description of 
       substitutions and preferred embodiments

<400>  173
ggganannan gngnnngann gnnnggang                                         29


<210>  174
<211>  29
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Synthetic: OH-26874-29_324


<220>
<221>  misc_feature
<222>  (1)..(29)
<223>  Every n is a C-5 modified pyrimidine such as Tyr-dU,  PP-dC, 
       Bn-dC,  Nap-dC,  2Nap-dC,  Tyr-dC,  PBn-dC,  DPP-dC,  and DCPE-dC

<220>
<221>  misc_feature
<222>  (1)..(29)
<223>  See specification as filed for detailed description of 
       substitutions and preferred embodiments

<400>  174
ggganannan gngnnngann gnnnggang                                         29


<210>  175
<211>  29
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Synthetic: OH-26874-29_325


<220>
<221>  misc_feature
<222>  (1)..(29)
<223>  Every n is a C-5 modified pyrimidine such as Tyr-dU,  PP-dC, 
       Bn-dC,  Nap-dC,  2Nap-dC,  Tyr-dC,  PBn-dC,  DPP-dC,  and DCPE-dC

<220>
<221>  misc_feature
<222>  (1)..(29)
<223>  See specification as filed for detailed description of 
       substitutions and preferred embodiments

<400>  175
ggganannan gngnnngann gnnnggang                                         29


<210>  176
<211>  29
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Synthetic: OH-26874-29_326


<220>
<221>  misc_feature
<222>  (1)..(29)
<223>  Every n is a C-5 modified pyrimidine such as Tyr-dU,  PP-dC, 
       Bn-dC,  Nap-dC,  2Nap-dC,  Tyr-dC,  PBn-dC,  DPP-dC,  and DCPE-dC

<220>
<221>  misc_feature
<222>  (1)..(29)
<223>  See specification as filed for detailed description of 
       substitutions and preferred embodiments

<400>  176
ggganannan gngnnngann gnnnggang                                         29


<210>  177
<211>  29
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Synthetic: OH-26874-29_327


<220>
<221>  misc_feature
<222>  (1)..(29)
<223>  Every n is a C-5 modified pyrimidine such as Tyr-dU,  PP-dC, 
       Bn-dC,  Nap-dC,  2Nap-dC,  Tyr-dC,  PBn-dC,  DPP-dC,  and DCPE-dC

<220>
<221>  misc_feature
<222>  (1)..(29)
<223>  See specification as filed for detailed description of 
       substitutions and preferred embodiments

<400>  177
ggganannan gngnnngann gnnnggang                                         29


<210>  178
<211>  29
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Synthetic: OH-26874-29_328


<220>
<221>  misc_feature
<222>  (1)..(29)
<223>  Every n is a C-5 modified pyrimidine such as Tyr-dU,  PP-dC, 
       Bn-dC,  Nap-dC,  2Nap-dC,  Tyr-dC,  PBn-dC,  DPP-dC,  and DCPE-dC

<220>
<221>  misc_feature
<222>  (1)..(29)
<223>  See specification as filed for detailed description of 
       substitutions and preferred embodiments

<400>  178
ggganannan gngnnngann gnnnggang                                         29


<210>  179
<211>  29
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Synthetic: OH-26874-29_329


<220>
<221>  misc_feature
<222>  (1)..(29)
<223>  Every n is a C-5 modified pyrimidine such as Tyr-dU,  PP-dC, 
       Bn-dC,  Nap-dC,  2Nap-dC,  Tyr-dC,  PBn-dC,  DPP-dC,  and DCPE-dC

<220>
<221>  misc_feature
<222>  (1)..(29)
<223>  See specification as filed for detailed description of 
       substitutions and preferred embodiments

<400>  179
ggganannan gngnnngann gnnnggang                                         29


<210>  180
<211>  29
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Synthetic: OH-26874-29_330


<220>
<221>  misc_feature
<222>  (1)..(29)
<223>  Every n is a C-5 modified pyrimidine such as Tyr-dU,  PP-dC, 
       Bn-dC,  Nap-dC,  2Nap-dC,  Tyr-dC,  PBn-dC,  DPP-dC,  and DCPE-dC

<220>
<221>  misc_feature
<222>  (1)..(29)
<223>  See specification as filed for detailed description of 
       substitutions and preferred embodiments

<400>  180
ggganannan gngnnngann gnnnggang                                         29


<210>  181
<211>  29
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Synthetic: OH-26874-29_331


<220>
<221>  misc_feature
<222>  (1)..(29)
<223>  Every n is a C-5 modified pyrimidine such as Tyr-dU,  PP-dC, 
       Bn-dC,  Nap-dC,  2Nap-dC,  Tyr-dC,  PBn-dC,  DPP-dC,  and DCPE-dC

<220>
<221>  misc_feature
<222>  (1)..(29)
<223>  See specification as filed for detailed description of 
       substitutions and preferred embodiments

<400>  181
ggganannan gngnnngann gnnnggang                                         29


<210>  182
<211>  29
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Synthetic: OH-26874-29_332


<220>
<221>  misc_feature
<222>  (1)..(29)
<223>  Every n is a C-5 modified pyrimidine such as Tyr-dU,  PP-dC, 
       Bn-dC,  Nap-dC,  2Nap-dC,  Tyr-dC,  PBn-dC,  DPP-dC,  and DCPE-dC

<220>
<221>  misc_feature
<222>  (1)..(29)
<223>  See specification as filed for detailed description of 
       substitutions and preferred embodiments

<400>  182
ggganannan gngnnngann gnnnggang                                         29


<210>  183
<211>  29
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Synthetic: OH-26874-29_333


<220>
<221>  misc_feature
<222>  (1)..(29)
<223>  Every n is a C-5 modified pyrimidine such as Tyr-dU,  PP-dC, 
       Bn-dC,  Nap-dC,  2Nap-dC,  Tyr-dC,  PBn-dC,  DPP-dC,  and DCPE-dC

<220>
<221>  misc_feature
<222>  (1)..(29)
<223>  See specification as filed for detailed description of 
       substitutions and preferred embodiments

<400>  183
ggganannan gngnnngann gnnnggang                                         29


<210>  184
<211>  29
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Synthetic: OH-26874-29_334


<220>
<221>  misc_feature
<222>  (1)..(29)
<223>  Every n is a C-5 modified pyrimidine such as Tyr-dU,  PP-dC, 
       Bn-dC,  Nap-dC,  2Nap-dC,  Tyr-dC,  PBn-dC,  DPP-dC,  and DCPE-dC

<220>
<221>  misc_feature
<222>  (1)..(29)
<223>  See specification as filed for detailed description of 
       substitutions and preferred embodiments

<400>  184
ggganannan gngnnngann gnnnggang                                         29


<210>  185
<211>  29
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Synthetic: OH-26874-29_335


<220>
<221>  misc_feature
<222>  (1)..(29)
<223>  Every n is a C-5 modified pyrimidine such as Tyr-dU,  PP-dC, 
       Bn-dC,  Nap-dC,  2Nap-dC,  Tyr-dC,  PBn-dC,  DPP-dC,  and DCPE-dC

<220>
<221>  misc_feature
<222>  (1)..(29)
<223>  See specification as filed for detailed description of 
       substitutions and preferred embodiments

<400>  185
ggganannan gngnnngann gnnnggang                                         29


<210>  186
<211>  29
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Synthetic: OH-26874-29_336


<220>
<221>  misc_feature
<222>  (1)..(29)
<223>  Every n is a C-5 modified pyrimidine such as Tyr-dU,  PP-dC, 
       Bn-dC,  Nap-dC,  2Nap-dC,  Tyr-dC,  PBn-dC,  DPP-dC,  and DCPE-dC

<220>
<221>  misc_feature
<222>  (1)..(29)
<223>  See specification as filed for detailed description of 
       substitutions and preferred embodiments

<400>  186
ggganannan gngnnngann gnnnggang                                         29


<210>  187
<211>  29
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Synthetic: OH-26874-29_337


<220>
<221>  misc_feature
<222>  (1)..(29)
<223>  Every n is a C-5 modified pyrimidine such as Tyr-dU,  PP-dC, 
       Bn-dC,  Nap-dC,  2Nap-dC,  Tyr-dC,  PBn-dC,  DPP-dC,  and DCPE-dC

<220>
<221>  misc_feature
<222>  (1)..(29)
<223>  See specification as filed for detailed description of 
       substitutions and preferred embodiments

<400>  187
ggganannan gngnnngann gnnnggang                                         29


<210>  188
<211>  29
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Synthetic: OH-26874-29_338


<220>
<221>  misc_feature
<222>  (1)..(29)
<223>  Every n is a C-5 modified pyrimidine such as Tyr-dU,  PP-dC, 
       Bn-dC,  Nap-dC,  2Nap-dC,  Tyr-dC,  PBn-dC,  DPP-dC,  and DCPE-dC

<220>
<221>  misc_feature
<222>  (1)..(29)
<223>  See specification as filed for detailed description of 
       substitutions and preferred embodiments

<400>  188
ggganannan gngnnngann gnnnggang                                         29


<210>  189
<211>  29
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Synthetic: OH-26874-29_339


<220>
<221>  misc_feature
<222>  (1)..(29)
<223>  Every n is a C-5 modified pyrimidine such as Tyr-dU,  PP-dC, 
       Bn-dC,  Nap-dC,  2Nap-dC,  Tyr-dC,  PBn-dC,  DPP-dC,  and DCPE-dC

<220>
<221>  misc_feature
<222>  (1)..(29)
<223>  See specification as filed for detailed description of 
       substitutions and preferred embodiments

<400>  189
ggganannan gngnnngann gnnnggang                                         29


<210>  190
<211>  29
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Synthetic: OH-26874-29_340


<220>
<221>  misc_feature
<222>  (1)..(29)
<223>  Every n is a C-5 modified pyrimidine such as Tyr-dU,  PP-dC, 
       Bn-dC,  Nap-dC,  2Nap-dC,  Tyr-dC,  PBn-dC,  DPP-dC,  and DCPE-dC

<220>
<221>  misc_feature
<222>  (1)..(29)
<223>  See specification as filed for detailed description of 
       substitutions and preferred embodiments

<400>  190
ggganannan gngnnngann gnnnggang                                         29


<210>  191
<211>  29
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Synthetic: OH-26874-29_354


<220>
<221>  misc_feature
<222>  (1)..(29)
<223>  Every n is a C-5 modified pyrimidine such as Tyr-dU,  PP-dC, 
       Bn-dC,  Nap-dC,  2Nap-dC,  Tyr-dC,  PBn-dC,  DPP-dC,  and DCPE-dC

<220>
<221>  misc_feature
<222>  (1)..(29)
<223>  See specification as filed for detailed description of 
       substitutions and preferred embodiments

<400>  191
gggauacuau gcguccgacc gcucggacg                                         29


<210>  192
<211>  50
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Synthetic: 26860-16_3


<220>
<221>  misc_feature
<222>  (1)..(50)
<223>  Every n is a C-5 modified pyrimidine such as Tyr-dU or Nap-dC - 
       see specification as filed for detailed description of 
       substitutions and preferred embodiments

<400>  192
gcatcggaan gaangncngc cnngcacngg ngcggnccga nngngaggga                  50


<210>  193
<211>  48
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Synthetic: 26860-16_5


<220>
<221>  misc_feature
<222>  (1)..(48)
<223>  Every n is a C-5 modified pyrimidine such as Tyr-dU or Nap-dC - 
       see specification as filed for detailed description of 
       substitutions and preferred embodiments

<400>  193
atcggaanga angncngccn ngcacnggng cggnccgann gngaggga                    48


<210>  194
<211>  46
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Synthetic: 26860-16_6


<220>
<221>  misc_feature
<222>  (1)..(46)
<223>  Every n is a C-5 modified pyrimidine such as Tyr-dU or Nap-dC - 
       see specification as filed for detailed description of 
       substitutions and preferred embodiments

<400>  194
cggaangaan gncngccnng cacnggngcg gnccganngn gaggga                      46


<210>  195
<211>  44
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Synthetic: 26860-16_7


<220>
<221>  misc_feature
<222>  (1)..(44)
<223>  Every n is a C-5 modified pyrimidine such as Tyr-dU or Nap-dC - 
       see specification as filed for detailed description of 
       substitutions and preferred embodiments

<400>  195
gaangaangn cngccnngca cnggngcggn ccganngnga ggga                        44


<210>  196
<211>  46
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Synthetic: 26860-16_11


<220>
<221>  misc_feature
<222>  (1)..(46)
<223>  Every n is a C-5 modified pyrimidine such as Tyr-dU or Nap-dC - 
       see specification as filed for detailed description of 
       substitutions and preferred embodiments

<400>  196
gcatcggaan gaangncngc cnngcacngg ngcggnccga nngnga                      46


<210>  197
<211>  44
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Synthetic: 26860-16_12


<220>
<221>  misc_feature
<222>  (1)..(44)
<223>  Every n is a C-5 modified pyrimidine such as Tyr-dU or Nap-dC - 
       see specification as filed for detailed description of 
       substitutions and preferred embodiments

<400>  197
gcatcggaan gaangncngc cnngcacngg ngcggnccga nngn                        44


<210>  198
<211>  42
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Synthetic: 26860-16_13


<220>
<221>  misc_feature
<222>  (1)..(42)
<223>  Every n is a C-5 modified pyrimidine such as Tyr-dU or Nap-dC - 
       see specification as filed for detailed description of 
       substitutions and preferred embodiments

<400>  198
gcatcggaan gaangncngc cnngcacngg ngcggnccga nn                          42


<210>  199
<211>  40
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Synthetic: 26860-16_14


<220>
<221>  misc_feature
<222>  (1)..(40)
<223>  Every n is a C-5 modified pyrimidine such as Tyr-dU or Nap-dC - 
       see specification as filed for detailed description of 
       substitutions and preferred embodiments

<400>  199
gcatcggaan gaangncngc cnngcacngg ngcggnccga                             40


<210>  200
<211>  38
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Synthetic: 26860-16_15


<220>
<221>  misc_feature
<222>  (1)..(38)
<223>  Every n is a C-5 modified pyrimidine such as Tyr-dU or Nap-dC - 
       see specification as filed for detailed description of 
       substitutions and preferred embodiments

<400>  200
atcggaanga angncngccn ngcacnggng cggnccga                               38


<210>  201
<211>  37
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Synthetic: 26860-16_16


<220>
<221>  misc_feature
<222>  (1)..(37)
<223>  Every n is a C-5 modified pyrimidine such as Tyr-dU or Nap-dC - 
       see specification as filed for detailed description of 
       substitutions and preferred embodiments

<400>  201
tcggaangaa ngncngccnn gcacnggngc ggnccga                                37


<210>  202
<211>  36
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Synthetic: 26860-16_17


<220>
<221>  misc_feature
<222>  (1)..(36)
<223>  Every n is a C-5 modified pyrimidine such as Tyr-dU or Nap-dC - 
       see specification as filed for detailed description of 
       substitutions and preferred embodiments

<400>  202
atcggaanga angncngccn ngcacnggng cggncc                                 36


<210>  203
<211>  35
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Synthetic: 26860-16_18


<220>
<221>  misc_feature
<222>  (1)..(35)
<223>  Every n is a C-5 modified pyrimidine such as Tyr-dU or Nap-dC - 
       see specification as filed for detailed description of 
       substitutions and preferred embodiments

<400>  203
tcggaangaa ngncngccnn gcacnggngc ggncc                                  35


<210>  204
<211>  34
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Synthetic: 26860-16_19


<220>
<221>  misc_feature
<222>  (1)..(34)
<223>  Every n is a C-5 modified pyrimidine such as Tyr-dU or Nap-dC - 
       see specification as filed for detailed description of 
       substitutions and preferred embodiments

<400>  204
atcggaanga angncngccn ngcacnggng cggn                                   34


<210>  205
<211>  33
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Synthetic: 26860-16_20


<220>
<221>  misc_feature
<222>  (1)..(33)
<223>  Every n is a C-5 modified pyrimidine such as Tyr-dU or Nap-dC - 
       see specification as filed for detailed description of 
       substitutions and preferred embodiments

<400>  205
tcggaangaa ngncngccnn gcacnggngc ggn                                    33


<210>  206
<211>  35
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Synthetic: 26860-16_28


<220>
<221>  misc_feature
<222>  (1)..(35)
<223>  Every n is a C-5 modified pyrimidine such as Tyr-dU or Nap-dC - 
       see specification as filed for detailed description of 
       substitutions and preferred embodiments

<400>  206
tcggaatgaa tgtctgcctt gcactggtgc ggtcc                                  35


<210>  207
<211>  50
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Synthetic: 26860-75_3


<220>
<221>  misc_feature
<222>  (1)..(50)
<223>  Every n is a C-5 modified pyrimidine such as Tyr-dU or Nap-dC - 
       see specification as filed for detailed description of 
       substitutions and preferred embodiments

<400>  207
gcatcancnc ccagcnaang agngncngaa nnggacnggn ccncngggga                  50


<210>  208
<211>  48
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Synthetic: 26860-75_5


<220>
<221>  misc_feature
<222>  (1)..(48)
<223>  Every n is a C-5 modified pyrimidine such as Tyr-dU or Nap-dC - 
       see specification as filed for detailed description of 
       substitutions and preferred embodiments

<400>  208
atcancnccc agcnaangag ngncngaann ggacnggncc ncngggga                    48


<210>  209
<211>  46
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Synthetic: 26860-75_6


<220>
<221>  misc_feature
<222>  (1)..(46)
<223>  Every n is a C-5 modified pyrimidine such as Tyr-dU or Nap-dC - 
       see specification as filed for detailed description of 
       substitutions and preferred embodiments

<400>  209
cancncccag cnaangagng ncngaanngg acnggnccnc ngggga                      46


<210>  210
<211>  44
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Synthetic: 26860-75_7


<220>
<221>  misc_feature
<222>  (1)..(44)
<223>  Every n is a C-5 modified pyrimidine such as Tyr-dU or Nap-dC - 
       see specification as filed for detailed description of 
       substitutions and preferred embodiments

<400>  210
ncncccagcn aangagngnc ngaannggac nggnccncng ggga                        44


<210>  211
<211>  42
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Synthetic: 26860-75_8


<220>
<221>  misc_feature
<222>  (1)..(42)
<223>  Every n is a C-5 modified pyrimidine such as Tyr-dU or Nap-dC - 
       see specification as filed for detailed description of 
       substitutions and preferred embodiments

<400>  211
ncccagcnaa ngagngncng aannggacng gnccncnggg ga                          42


<210>  212
<211>  40
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Synthetic: 26860-75_9


<220>
<221>  misc_feature
<222>  (1)..(40)
<223>  Every n is a C-5 modified pyrimidine such as Tyr-dU or Nap-dC - 
       see specification as filed for detailed description of 
       substitutions and preferred embodiments

<400>  212
ccagcnaang agngncngaa nnggacnggn ccncngggga                             40


<210>  213
<211>  48
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Synthetic: 26860-75_10


<220>
<221>  misc_feature
<222>  (1)..(48)
<223>  Every n is a C-5 modified pyrimidine such as Tyr-dU or Nap-dC - 
       see specification as filed for detailed description of 
       substitutions and preferred embodiments

<400>  213
gcatcancnc ccagcnaang agngncngaa nnggacnggn ccncnggg                    48


<210>  214
<211>  46
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Synthetic: 26860-75_11


<220>
<221>  misc_feature
<222>  (1)..(46)
<223>  Every n is a C-5 modified pyrimidine such as Tyr-dU or Nap-dC - 
       see specification as filed for detailed description of 
       substitutions and preferred embodiments

<400>  214
gcatcancnc ccagcnaang agngncngaa nnggacnggn ccncng                      46


<210>  215
<211>  40
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Synthetic: 26860-75_14


<220>
<221>  misc_feature
<222>  (1)..(40)
<223>  Every n is a C-5 modified pyrimidine such as Tyr-dU or Nap-dC - 
       see specification as filed for detailed description of 
       substitutions and preferred embodiments

<400>  215
gcatcancnc ccagcnaang agngncngaa nnggacnggn                             40


<210>  216
<211>  46
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Synthetic: 26860-75_15


<220>
<221>  misc_feature
<222>  (1)..(46)
<223>  Every n is a C-5 modified pyrimidine such as Tyr-dU or Nap-dC - 
       see specification as filed for detailed description of 
       substitutions and preferred embodiments

<400>  216
atcancnccc agcnaangag ngncngaann ggacnggncc ncnggg                      46


<210>  217
<211>  45
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Synthetic: 26860-75_16


<220>
<221>  misc_feature
<222>  (1)..(45)
<223>  Every n is a C-5 modified pyrimidine such as Tyr-dU or Nap-dC - 
       see specification as filed for detailed description of 
       substitutions and preferred embodiments

<400>  217
tcancnccca gcnaangagn gncngaanng gacnggnccn cnggg                       45


<210>  218
<211>  45
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Synthetic: 26860-75_17


<220>
<221>  misc_feature
<222>  (1)..(45)
<223>  Every n is a C-5 modified pyrimidine such as Tyr-dU or Nap-dC - 
       see specification as filed for detailed description of 
       substitutions and preferred embodiments

<400>  218
atcancnccc agcnaangag ngncngaann ggacnggncc ncngg                       45


<210>  219
<211>  44
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Synthetic: 26860-75_18


<220>
<221>  misc_feature
<222>  (1)..(44)
<223>  Every n is a C-5 modified pyrimidine such as Tyr-dU or Nap-dC - 
       see specification as filed for detailed description of 
       substitutions and preferred embodiments

<400>  219
tcancnccca gcnaangagn gncngaanng gacnggnccn cngg                        44


<210>  220
<211>  44
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Synthetic: 26860-75_26


<220>
<221>  misc_feature
<222>  (1)..(44)
<223>  Every n is a C-5 modified pyrimidine such as Tyr-dU or Nap-dC - 
       see specification as filed for detailed description of 
       substitutions and preferred embodiments

<400>  220
tcatctccca gctaatgagt gtctgaattg gactggtcct ctgg                        44


<210>  221
<211>  40
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Synthetic: 26876-3_4


<220>
<221>  misc_feature
<222>  (1)..(40)
<223>  Every n is a C-5 modified pyrimidine such as Tyr-dU or Nap-dC - 
       see specification as filed for detailed description of 
       substitutions and preferred embodiments

<400>  221
ccttgnaggn ggnananggn annnnanann gagnggaagg                             40


<210>  222
<211>  38
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Synthetic: 26876-3_5


<220>
<221>  misc_feature
<222>  (1)..(38)
<223>  Every n is a C-5 modified pyrimidine such as Tyr-dU or Nap-dC - 
       see specification as filed for detailed description of 
       substitutions and preferred embodiments

<400>  222
ttgnaggngg nananggnan nnnanannga gnggaagg                               38


<210>  223
<211>  36
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Synthetic: 26876-3_6


<220>
<221>  misc_feature
<222>  (1)..(36)
<223>  Every n is a C-5 modified pyrimidine such as Tyr-dU or Nap-dC - 
       see specification as filed for detailed description of 
       substitutions and preferred embodiments

<400>  223
gnaggnggna nanggnannn nananngagn ggaagg                                 36


<210>  224
<211>  34
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Synthetic: 26876-3_7


<220>
<221>  misc_feature
<222>  (1)..(34)
<223>  Every n is a C-5 modified pyrimidine such as Tyr-dU or Nap-dC - 
       see specification as filed for detailed description of 
       substitutions and preferred embodiments

<400>  224
aggnggnana nggnannnna nanngagngg aagg                                   34


<210>  225
<211>  32
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Synthetic: 26876-3_8


<220>
<221>  misc_feature
<222>  (1)..(32)
<223>  Every n is a C-5 modified pyrimidine such as Tyr-dU or Nap-dC - 
       see specification as filed for detailed description of 
       substitutions and preferred embodiments

<400>  225
gnggnanang gnannnnana nngagnggaa gg                                     32


<210>  226
<211>  30
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Synthetic: 26876-3_9


<220>
<221>  misc_feature
<222>  (1)..(30)
<223>  Every n is a C-5 modified pyrimidine such as Tyr-dU or Nap-dC - 
       see specification as filed for detailed description of 
       substitutions and preferred embodiments

<400>  226
ggnananggn annnnanann gagnggaagg                                        30


<210>  227
<211>  38
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Synthetic: 26876-3_10


<220>
<221>  misc_feature
<222>  (1)..(38)
<223>  Every n is a C-5 modified pyrimidine such as Tyr-dU or Nap-dC - 
       see specification as filed for detailed description of 
       substitutions and preferred embodiments

<400>  227
ccttgnaggn ggnananggn annnnanann gagnggaa                               38


<210>  228
<211>  36
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Synthetic: 26876-3_11


<220>
<221>  misc_feature
<222>  (1)..(36)
<223>  Every n is a C-5 modified pyrimidine such as Tyr-dU or Nap-dC - 
       see specification as filed for detailed description of 
       substitutions and preferred embodiments

<400>  228
ccttgnaggn ggnananggn annnnanann gagngg                                 36


<210>  229
<211>  34
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Synthetic: 26876-3_12


<220>
<221>  misc_feature
<222>  (1)..(34)
<223>  Every n is a C-5 modified pyrimidine such as Tyr-dU or Nap-dC - 
       see specification as filed for detailed description of 
       substitutions and preferred embodiments

<400>  229
ccttgnaggn ggnananggn annnnanann gagn                                   34


<210>  230
<211>  32
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Synthetic: 26876-3_13


<220>
<221>  misc_feature
<222>  (1)..(32)
<223>  Every n is a C-5 modified pyrimidine such as Tyr-dU or Nap-dC - 
       see specification as filed for detailed description of 
       substitutions and preferred embodiments

<400>  230
ccttgnaggn ggnananggn annnnanann ga                                     32


<210>  231
<211>  30
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Synthetic: 26876-3_14


<220>
<221>  misc_feature
<222>  (1)..(30)
<223>  Every n is a C-5 modified pyrimidine such as Tyr-dU or Nap-dC - 
       see specification as filed for detailed description of 
       substitutions and preferred embodiments

<400>  231
ccttgnaggn ggnananggn annnnanann                                        30


<210>  232
<211>  30
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Synthetic: 26876-3_15


<220>
<221>  misc_feature
<222>  (1)..(30)
<223>  Every n is a C-5 modified pyrimidine such as Tyr-dU or Nap-dC - 
       see specification as filed for detailed description of 
       substitutions and preferred embodiments

<400>  232
aggnggnana nggnannnna nanngagngg                                        30


<210>  233
<211>  29
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Synthetic: 26876-3_16


<220>
<221>  misc_feature
<222>  (1)..(29)
<223>  Every n is a C-5 modified pyrimidine such as Tyr-dU or Nap-dC - 
       see specification as filed for detailed description of 
       substitutions and preferred embodiments

<400>  233
aggnggnana nggnannnna nanngagng                                         29


<210>  234
<211>  29
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Synthetic: 26876-3_17


<220>
<221>  misc_feature
<222>  (1)..(29)
<223>  Every n is a C-5 modified pyrimidine such as Tyr-dU or Nap-dC - 
       see specification as filed for detailed description of 
       substitutions and preferred embodiments

<400>  234
ggnggnanan ggnannnnan anngagngg                                         29


<210>  235
<211>  28
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Synthetic: 26876-3_18


<220>
<221>  misc_feature
<222>  (1)..(28)
<223>  Every n is a C-5 modified pyrimidine such as Tyr-dU or Nap-dC - 
       see specification as filed for detailed description of 
       substitutions and preferred embodiments

<400>  235
ggnggnanan ggnannnnan anngagng                                          28


<210>  236
<211>  27
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Synthetic: 26876-3_20


<220>
<221>  misc_feature
<222>  (1)..(27)
<223>  Every n is a C-5 modified pyrimidine such as Tyr-dU or Nap-dC - 
       see specification as filed for detailed description of 
       substitutions and preferred embodiments

<400>  236
ggnggnanan ggnannnnan anngagn                                           27


<210>  237
<211>  26
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Synthetic: 26876-3_21


<220>
<221>  misc_feature
<222>  (1)..(26)
<223>  Every n is a C-5 modified pyrimidine such as Tyr-dU or Nap-dC - 
       see specification as filed for detailed description of 
       substitutions and preferred embodiments

<400>  237
gnggnanang gnannnnana nngagn                                            26


<210>  238
<211>  28
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Synthetic: 26876-3_36


<220>
<221>  misc_feature
<222>  (1)..(28)
<223>  Every n is a C-5 modified pyrimidine such as Tyr-dU or Nap-dC - 
       see specification as filed for detailed description of 
       substitutions and preferred embodiments

<400>  238
ggcggcacat ggcacttcat atcgagcg                                          28


<210>  239
<211>  40
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Synthetic: 26876-13_4


<220>
<221>  misc_feature
<222>  (1)..(40)
<223>  Every n is a C-5 modified pyrimidine such as Tyr-dU or Nap-dC - 
       see specification as filed for detailed description of 
       substitutions and preferred embodiments

<400>  239
ccttgngnaa ngnannnnan nnggnnngaa ngngagaagg                             40


<210>  240
<211>  38
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Synthetic: 26876-13_5


<220>
<221>  misc_feature
<222>  (1)..(38)
<223>  Every n is a C-5 modified pyrimidine such as Tyr-dU or Nap-dC - 
       see specification as filed for detailed description of 
       substitutions and preferred embodiments

<400>  240
ttgngnaang nannnnannn ggnnngaang ngagaagg                               38


<210>  241
<211>  36
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Synthetic: 26876-13_6


<220>
<221>  misc_feature
<222>  (1)..(36)
<223>  Every n is a C-5 modified pyrimidine such as Tyr-dU or Nap-dC - 
       see specification as filed for detailed description of 
       substitutions and preferred embodiments

<400>  241
gngnaangna nnnnannngg nnngaangng agaagg                                 36


<210>  242
<211>  38
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Synthetic: 26876-13_10


<220>
<221>  misc_feature
<222>  (1)..(38)
<223>  Every n is a C-5 modified pyrimidine such as Tyr-dU or Nap-dC - 
       see specification as filed for detailed description of 
       substitutions and preferred embodiments

<400>  242
ccttgngnaa ngnannnnan nnggnnngaa ngngagaa                               38


<210>  243
<211>  36
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Synthetic: 26876-13_11


<220>
<221>  misc_feature
<222>  (1)..(36)
<223>  Every n is a C-5 modified pyrimidine such as Tyr-dU or Nap-dC - 
       see specification as filed for detailed description of 
       substitutions and preferred embodiments

<400>  243
ccttgngnaa ngnannnnan nnggnnngaa ngngag                                 36


<210>  244
<211>  34
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Synthetic: 26876-13_12


<220>
<221>  misc_feature
<222>  (1)..(34)
<223>  Every n is a C-5 modified pyrimidine such as Tyr-dU or Nap-dC - 
       see specification as filed for detailed description of 
       substitutions and preferred embodiments

<400>  244
ccttgngnaa ngnannnnan nnggnnngaa ngng                                   34


<210>  245
<211>  32
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Synthetic: 26876-13_13


<220>
<221>  misc_feature
<222>  (1)..(32)
<223>  Every n is a C-5 modified pyrimidine such as Tyr-dU or Nap-dC - 
       see specification as filed for detailed description of 
       substitutions and preferred embodiments

<400>  245
ccttgngnaa ngnannnnan nnggnnngaa ng                                     32


<210>  246
<211>  30
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Synthetic: 26876-13_14


<220>
<221>  misc_feature
<222>  (1)..(30)
<223>  Every n is a C-5 modified pyrimidine such as Tyr-dU or Nap-dC - 
       see specification as filed for detailed description of 
       substitutions and preferred embodiments

<400>  246
ccttgngnaa ngnannnnan nnggnnngaa                                        30


<210>  247
<211>  30
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Synthetic: 26876-13_15


<220>
<221>  misc_feature
<222>  (1)..(30)
<223>  Every n is a C-5 modified pyrimidine such as Tyr-dU or Nap-dC - 
       see specification as filed for detailed description of 
       substitutions and preferred embodiments

<400>  247
gngnaangna nnnnannngg nnngaangng                                        30


<210>  248
<211>  29
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Synthetic: 26876-13_16


<220>
<221>  misc_feature
<222>  (1)..(29)
<223>  Every n is a C-5 modified pyrimidine such as Tyr-dU or Nap-dC - 
       see specification as filed for detailed description of 
       substitutions and preferred embodiments

<400>  248
ngnaangnan nnnannnggn nngaangng                                         29


<210>  249
<211>  29
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Synthetic: 26876-13_17


<220>
<221>  misc_feature
<222>  (1)..(29)
<223>  Every n is a C-5 modified pyrimidine such as Tyr-dU or Nap-dC - 
       see specification as filed for detailed description of 
       substitutions and preferred embodiments

<400>  249
gngnaangna nnnnannngg nnngaangn                                         29


<210>  250
<211>  28
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Synthetic: 26876-13_18


<220>
<221>  misc_feature
<222>  (1)..(28)
<223>  Every n is a C-5 modified pyrimidine such as Tyr-dU or Nap-dC - 
       see specification as filed for detailed description of 
       substitutions and preferred embodiments

<400>  250
ngnaangnan nnnannnggn nngaangn                                          28


<210>  251
<211>  28
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Synthetic: 26876-13_26


<220>
<221>  misc_feature
<222>  (1)..(28)
<223>  Every n is a C-5 modified pyrimidine such as Tyr-dU or Nap-dC - 
       see specification as filed for detailed description of 
       substitutions and preferred embodiments

<400>  251
tgcaacgcac cttattcggc ttgaatgt                                          28


<210>  252
<211>  28
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Synthetic: aptamer

<400>  252
ggcggcacat ggcacttcat atcgagcg                                          28


<210>  253
<211>  28
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Synthetic: aptamer


<220>
<221>  misc_feature
<223>  See specification as filed for detailed description of 
       substitutions and preferred embodiments

<220>
<221>  misc_feature
<222>  (1)..(1)
<223>  n is dA, dG or a C-5 modified pyrimidine nucleoside

<220>
<221>  misc_feature
<222>  (3)..(3)
<223>  n is dA or a C-5 modified pyrimidine nucleoside

<220>
<221>  misc_feature
<222>  (6)..(6)
<223>  n is a C-5 modified pyrimidine nucleoside

<220>
<221>  misc_feature
<222>  (7)..(7)
<223>  n is is dA or the C-5 modified pyrimidine Tyr-dU

<220>
<221>  misc_feature
<222>  (8)..(8)
<223>  n is a C-5 modified pyrimidine nucleoside

<220>
<221>  misc_feature
<222>  (9)..(9)
<223>  n is is dA or the C-5 modified pyrimidine Tyr-dU

<220>
<221>  misc_feature
<222>  (10)..(10)
<223>  n is a C-5 modified pyrimidine nucleoside

<220>
<221>  misc_feature
<222>  (13)..(13)
<223>  n is a C-5 modified pyrimidine nucleoside

<220>
<221>  misc_feature
<222>  (14)..(14)
<223>  n is is dA or the C-5 modified pyrimidine Tyr-dU

<220>
<221>  misc_feature
<222>  (15)..(15)
<223>  n is a C-5 modified pyrimidine nucleoside

<220>
<221>  misc_feature
<222>  (16)..(16)
<223>  n is a C-5 modified pyrimidine nucleoside

<220>
<221>  misc_feature
<222>  (17)..(17)
<223>  n is a C-5 modified pyrimidine nucleoside

<220>
<221>  misc_feature
<222>  (18)..(18)
<223>  n is a C-5 modified pyrimidine nucleoside

<220>
<221>  misc_feature
<222>  (19)..(19)
<223>  n is dA, dG or a C-5 modified pyrimidine nucleoside

<220>
<221>  misc_feature
<222>  (20)..(20)
<223>  n is is dA or the C-5 modified pyrimidine Tyr-dU

<220>
<221>  misc_feature
<222>  (21)..(21)
<223>  n is dA, dG or a C-5 modified pyrimidine nucleoside

<220>
<221>  misc_feature
<222>  (22)..(22)
<223>  n is a C-5 modified pyrimidine nucleoside

<220>
<221>  misc_feature
<222>  (23)..(23)
<223>  n is a C-5 modified pyrimidine nucleoside

<220>
<221>  misc_feature
<222>  (27)..(27)
<223>  n is dA or a C-5 modified pyrimidine nucleoside

<400>  253
nrnrrnnnnn grnnnnnnnn nnnrarnr                                          28


<210>  254
<211>  28
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Synthetic: aptamer

<400>  254
tgcaacgcac cttattcggc ttgaatgt                                          28


<210>  255
<211>  28
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Synthetic: aptamer


<220>
<221>  misc_feature
<223>  See specification as filed for detailed description of 
       substitutions and preferred embodiments

<220>
<221>  misc_feature
<222>  (1)..(1)
<223>  n is Tyr-dU

<220>
<221>  misc_feature
<222>  (3)..(3)
<223>  n is Nap-dC or Tyr-dU

<220>
<221>  misc_feature
<222>  (4)..(4)
<223>  n is dA, dG or Tyr-dU

<220>
<221>  misc_feature
<222>  (6)..(6)
<223>  n is Nap-dC or Tyr-dU

<220>
<221>  misc_feature
<222>  (8)..(8)
<223>  n is Nap-dC or Tyr-dU

<220>
<221>  misc_feature
<222>  (9)..(9)
<223>  n is dA or Tyr-dU

<220>
<221>  misc_feature
<222>  (10)..(10)
<223>  n is Nap-dC or Tyr-dU

<220>
<221>  misc_feature
<222>  (11)..(11)
<223>  n is Nap-dC or Tyr-dU

<220>
<221>  misc_feature
<222>  (12)..(12)
<223>  n is dA or Tyr-dU

<220>
<221>  misc_feature
<222>  (13)..(13)
<223>  n is Tyr-dU

<220>
<221>  misc_feature
<222>  (14)..(14)
<223>  n is dA or Tyr-dU

<220>
<221>  misc_feature
<222>  (15)..(15)
<223>  n is Tyr-dU

<220>
<221>  misc_feature
<222>  (16)..(16)
<223>  n is Tyr-dU

<220>
<221>  misc_feature
<222>  (17)..(17)
<223>  n is dA, Nap-dC or Tyr-dU

<220>
<221>  misc_feature
<222>  (20)..(20)
<223>  n is Nap-dC or Tyr-dU

<220>
<221>  misc_feature
<222>  (21)..(21)
<223>  n is dA, Nap-dC or Tyr-dU

<220>
<221>  misc_feature
<222>  (22)..(22)
<223>  n is Tyr-dU

<220>
<221>  misc_feature
<222>  (26)..(26)
<223>  n is dA, Nap-dC, dG or Tyr-dU

<220>
<221>  misc_feature
<222>  (27)..(27)
<223>  n is dA, dG or Tyr-dU

<220>
<221>  misc_feature
<222>  (28)..(28)
<223>  n is Nap-dC, dG or Tyr-dU

<400>  255
nrnnrnrnnn nnnnnnnrrn nnrrrnnn                                          28


<210>  256
<211>  44
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Synthetic: aptamer

<400>  256
tcatctccca gctaatgagt gtctgaattg gactggtcct ctgg                        44


<210>  257
<211>  44
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Synthetic: aptamer


<220>
<221>  misc_feature
<223>  See specification as filed for detailed description of 
       substitutions and preferred embodiments

<220>
<221>  misc_feature
<222>  (1)..(1)
<223>  n is Nap-dU

<220>
<221>  misc_feature
<222>  (3)..(3)
<223>  n is dA, dG or Nap-dU

<220>
<221>  misc_feature
<222>  (4)..(4)
<223>  n is dA, dC or Nap-dU

<220>
<221>  misc_feature
<222>  (6)..(6)
<223>  n is dA, dC or Nap-dU

<220>
<221>  misc_feature
<222>  (7)..(7)
<223>  n is dC or Nap-dU

<220>
<221>  misc_feature
<222>  (9)..(9)
<223>  n is dC or Nap-dU

<220>
<221>  misc_feature
<222>  (10)..(10)
<223>  n is dA or Nap-dU

<220>
<221>  misc_feature
<222>  (12)..(12)
<223>  n is dC or Nap-dU

<220>
<221>  misc_feature
<222>  (13)..(13)
<223>  n is Nap-dU

<220>
<221>  misc_feature
<222>  (16)..(16)
<223>  n is dC or Nap-dU

<220>
<221>  misc_feature
<222>  (20)..(20)
<223>  n is Nap-dU

<220>
<221>  misc_feature
<222>  (22)..(22)
<223>  n is Nap-dU

<220>
<221>  misc_feature
<222>  (24)..(24)
<223>  n is Nap-dU

<220>
<221>  misc_feature
<222>  (27)..(27)
<223>  n is dA, dG or Nap-dU

<220>
<221>  misc_feature
<222>  (28)..(28)
<223>  n is Nap-dU

<220>
<221>  misc_feature
<222>  (29)..(29)
<223>  n is Nap-dU

<220>
<221>  misc_feature
<222>  (33)..(33)
<223>  n is dC or Nap-dU

<220>
<221>  misc_feature
<222>  (34)..(34)
<223>  n is dC or Nap-dU

<220>
<221>  misc_feature
<222>  (37)..(37)
<223>  n is Nap-dU

<220>
<221>  misc_feature
<222>  (39)..(39)
<223>  n is dC or Nap-dU

<220>
<221>  misc_feature
<222>  (40)..(40)
<223>  n is Nap-dU

<220>
<221>  misc_feature
<222>  (42)..(42)
<223>  n is dC or Nap-dU

<400>  257
ncnncnncnn rnnarnrarn rncnrannng gannrrncnn mngg                        44


<210>  258
<211>  35
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Synthetic: aptamer

<400>  258
atctaatgaa tgtctgcctt gcactggtgc gttcc                                  35


<210>  259
<211>  35
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Synthetic: aptamer


<220>
<221>  misc_feature
<223>  See specification as filed for detailed description of 
       substitutions and preferred embodiments

<220>
<221>  misc_feature
<222>  (1)..(1)
<223>  n is dA, dC or Nap-dU

<220>
<221>  misc_feature
<222>  (2)..(2)
<223>  n is dC or Nap-dU

<220>
<221>  misc_feature
<222>  (3)..(3)
<223>  n is dC, dG or Nap-dU

<220>
<221>  misc_feature
<222>  (4)..(4)
<223>  n is dA or Nap-dU

<220>
<221>  misc_feature
<222>  (5)..(5)
<223>  n is dA, dG or Nap-dU

<220>
<221>  misc_feature
<222>  (6)..(6)
<223>  n is dA or Nap-dU

<220>
<221>  misc_feature
<222>  (7)..(7)
<223>  n is dA or Nap-dU

<220>
<221>  misc_feature
<222>  (11)..(11)
<223>  n is Nap-dU

<220>
<221>  misc_feature
<222>  (13)..(13)
<223>  n is Nap-dU

<220>
<221>  misc_feature
<222>  (15)..(15)
<223>  n is Nap-dU

<220>
<221>  misc_feature
<222>  (17)..(17)
<223>  n is dA, dC, dG or Nap-dU

<220>
<221>  misc_feature
<222>  (18)..(18)
<223>  n is dC or Nap-dU

<220>
<221>  misc_feature
<222>  (19)..(19)
<223>  n is Nap-dU

<220>
<221>  misc_feature
<222>  (20)..(20)
<223>  n is Nap-dU

<220>
<221>  misc_feature
<222>  (24)..(24)
<223>  n is dC or Nap-dU

<220>
<221>  misc_feature
<222>  (25)..(25)
<223>  n is Nap-dU

<220>
<221>  misc_feature
<222>  (28)..(28)
<223>  n is Nap-dU

<220>
<221>  misc_feature
<222>  (30)..(30)
<223>  n is dC or Nap-dU

<220>
<221>  misc_feature
<222>  (31)..(31)
<223>  n is dC, dG or Nap-dU

<220>
<221>  misc_feature
<222>  (32)..(32)
<223>  n is dA, dG or Nap-dU

<220>
<221>  misc_feature
<222>  (33)..(33)
<223>  n is dC or Nap-dU

<220>
<221>  misc_feature
<222>  (34)..(34)
<223>  n is dA, dC, dG or Nap-dU

<220>
<221>  misc_feature
<222>  (35)..(35)
<223>  n is dA, dC, dG or Nap-dU

<400>  259
nnnnnnnrar ngncnvnnnn gcannvgngn nnnnn                                  35


<210>  260
<211>  20
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Synthetic: primer

<400>  260
ggtcgggcac actacgcatc                                                   20


<210>  261
<211>  21
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Synthetic: primer

<400>  261
gggaagagaa aggagaagaa g                                                 21


<210>  262
<211>  20
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Synthetic: primer

<400>  262
ggtcgggcac actacgcatc                                                   20


<210>  263
<211>  21
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Synthetic: primer

<400>  263
gggaagagaa aggagaagaa g                                                 21


<210>  264
<211>  13
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic: amino acid

<400>  264

Lys Cys Tyr Gly Val Ser Pro Thr Lys Leu Asn Asp Leu 
1               5                   10              


<210>  265
<211>  11
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic: amino acid

<400>  265

Asp Ser Lys Val Gly Gly Asn Tyr Asn Tyr Leu 
1               5                   10      


<210>  266
<211>  17
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic: amino acid

<400>  266

Glu Ile Tyr Gln Ala Gly Ser Thr Pro Cys Asn Gly Val Glu Gly Phe 
1               5                   10                  15      


Asn 
    


<210>  267
<211>  18
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic: amino acid

<400>  267

Tyr Gly Phe Gln Pro Thr Asn Gly Val Gly Tyr Gln Pro Tyr Arg Val 
1               5                   10                  15      


Val Val 
        


<210>  268
<211>  19
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic: amino acid

<400>  268

Phe Glu Leu Leu His Ala Pro Ala Thr Val Cys Gly Pro Lys Lys Ser 
1               5                   10                  15      


Thr Asn Leu 
            


