                               SEQUENCE LISTING

<110> TSCAN THERAPEUTICS, INC.
 
<120> MAGEC2 IMMUNOGENIC PEPTIDES, BINDING PROTEINS RECOGNIZING MAGEC2
      IMMUNOGENIC PEPTIDES, AND USES THEREOF

<130> TTC-00825

<140> PCT/US2022/024728
<141> 2022-04-14

<150> 63/329,523
<151> 2022-04-11

<150> 63/174,808
<151> 2021-04-14

<160> 81    

<170> PatentIn version 3.5

<210> 1
<211> 9
<212> PRT
<213> Homo sapiens

<400> 1
Ala Leu Lys Asp Val Glu Glu Arg Val 
1               5                   


<210> 2
<211> 10
<212> PRT
<213> Homo sapiens

<400> 2
Leu Leu Phe Gly Leu Ala Leu Ile Glu Val 
1               5                   10  


<210> 3
<211> 9
<212> PRT
<213> Homo sapiens

<400> 3
Ser Glu Ser Ile Lys Lys Lys Val Leu 
1               5                   


<210> 4
<211> 9
<212> PRT
<213> Homo sapiens

<400> 4
Ala Ser Ser Thr Leu Tyr Leu Val Phe 
1               5                   


<210> 5
<211> 9
<212> PRT
<213> Homo sapiens

<400> 5
Arg Ala Arg Glu Phe Met Glu Leu Leu 
1               5                   


<210> 6
<211> 9
<212> PRT
<213> Homo sapiens

<400> 6
Val Gly Pro Asp His Phe Cys Val Phe 
1               5                   


<210> 7
<211> 8
<212> PRT
<213> Homo sapiens

<400> 7
Arg Ala Arg Glu Phe Met Glu Leu 
1               5               


<210> 8
<211> 10
<212> PRT
<213> Homo sapiens

<400> 8
Arg Ala Arg Glu Phe Met Glu Leu Leu Phe 
1               5                   10  


<210> 9
<211> 10
<212> PRT
<213> Homo sapiens

<400> 9
Leu Lys Arg Ala Arg Glu Phe Met Glu Leu 
1               5                   10  


<210> 10
<211> 9
<212> PRT
<213> Homo sapiens

<400> 10
Val Ile Leu Lys Arg Ala Arg Glu Phe 
1               5                   


<210> 11
<211> 9
<212> PRT
<213> Homo sapiens

<400> 11
Phe Pro Val Ile Leu Lys Arg Ala Arg 
1               5                   


<210> 12
<211> 9
<212> PRT
<213> Homo sapiens

<400> 12
Lys Arg Ala Arg Glu Phe Met Glu Leu 
1               5                   


<210> 13
<211> 10
<212> PRT
<213> Homo sapiens

<400> 13
Lys Arg Ala Arg Glu Phe Met Glu Leu Leu 
1               5                   10  


<210> 14
<211> 11
<212> PRT
<213> Homo sapiens

<400> 14
Leu Lys Arg Ala Arg Glu Phe Met Glu Leu Leu 
1               5                   10      


<210> 15
<211> 11
<212> PRT
<213> Homo sapiens

<400> 15
Arg Ala Arg Glu Phe Met Glu Leu Leu Phe Gly 
1               5                   10      


<210> 16
<211> 10
<212> PRT
<213> Homo sapiens

<400> 16
Val Gly Pro Asp His Phe Cys Val Phe Ala 
1               5                   10  


<210> 17
<211> 11
<212> PRT
<213> Homo sapiens

<400> 17
Val Gly Pro Asp His Phe Cys Val Phe Ala Asn 
1               5                   10      


<210> 18
<211> 8
<212> PRT
<213> Homo sapiens

<400> 18
Val Gly Pro Asp His Phe Cys Val 
1               5               


<210> 19
<211> 8
<212> PRT
<213> Homo sapiens

<400> 19
Gly Pro Asp His Phe Cys Val Phe 
1               5               


<210> 20
<211> 10
<212> PRT
<213> Homo sapiens

<400> 20
Glu Val Gly Pro Asp His Phe Cys Val Phe 
1               5                   10  


<210> 21
<211> 11
<212> PRT
<213> Homo sapiens

<400> 21
Ile Glu Val Gly Pro Asp His Phe Cys Val Phe 
1               5                   10      


<210> 22
<211> 828
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      polynucleotide

<400> 22
atggagaaga atcctttggc agccccactt cttatcctct ggtttcatct tgactgcgtg       60

agcagcattc tgaacgtgga acaaagtcct cagtcactgc atgttcagga gggagacagc      120

accaatttca cctgcagctt cccttccagc aatttttatg cccttcactg gtacagatgg      180

gaaactgcaa aaagccccga ggccttgttt gttatgactc ttaatgggga tgaaaagaag      240

aaaggacgca ttagtgccac tcttaatacc aaggagggtt acagctattt gtatatcaaa      300

ggatcccagc ctgaggactc agccacatac ctctgtgcct ccggaagtgg tggtgctaca      360

aacaagctca tctttggaac tggcactctg cttgctgtcc agccaaatat ccagaaccct      420

gaccctgccg tgtaccagct gagagactct aaatccagtg acaagtctgt ctgcctattc      480

accgattttg attctcaaac aaatgtgtca caaagtaagg attctgatgt gtatatcaca      540

gacaaaactg tgctagacat gaggtctatg gacttcaaga gcaacagtgc tgtggcctgg      600

agcaacaaat ctgactttgc atgtgcaaac gccttcaaca acagcattat tccagaagac      660

accttcttcc ccagcccaga aagttcctgt gatgtcaagc tggtcgagaa aagctttgaa      720

acagatacga acctaaactt tcaaaacctg tcagtgattg ggttccgaat cctcctcctg      780

aaagtggccg ggtttaatct gctcatgacg ctgcggctgt ggtccagc                   828


<210> 23
<211> 276
<212> PRT
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      polypeptide

<400> 23
Met Glu Lys Asn Pro Leu Ala Ala Pro Leu Leu Ile Leu Trp Phe His 
1               5                   10                  15      


Leu Asp Cys Val Ser Ser Ile Leu Asn Val Glu Gln Ser Pro Gln Ser 
            20                  25                  30          


Leu His Val Gln Glu Gly Asp Ser Thr Asn Phe Thr Cys Ser Phe Pro 
        35                  40                  45              


Ser Ser Asn Phe Tyr Ala Leu His Trp Tyr Arg Trp Glu Thr Ala Lys 
    50                  55                  60                  


Ser Pro Glu Ala Leu Phe Val Met Thr Leu Asn Gly Asp Glu Lys Lys 
65                  70                  75                  80  


Lys Gly Arg Ile Ser Ala Thr Leu Asn Thr Lys Glu Gly Tyr Ser Tyr 
                85                  90                  95      


Leu Tyr Ile Lys Gly Ser Gln Pro Glu Asp Ser Ala Thr Tyr Leu Cys 
            100                 105                 110         


Ala Ser Gly Ser Gly Gly Ala Thr Asn Lys Leu Ile Phe Gly Thr Gly 
        115                 120                 125             


Thr Leu Leu Ala Val Gln Pro Asn Ile Gln Asn Pro Asp Pro Ala Val 
    130                 135                 140                 


Tyr Gln Leu Arg Asp Ser Lys Ser Ser Asp Lys Ser Val Cys Leu Phe 
145                 150                 155                 160 


Thr Asp Phe Asp Ser Gln Thr Asn Val Ser Gln Ser Lys Asp Ser Asp 
                165                 170                 175     


Val Tyr Ile Thr Asp Lys Thr Val Leu Asp Met Arg Ser Met Asp Phe 
            180                 185                 190         


Lys Ser Asn Ser Ala Val Ala Trp Ser Asn Lys Ser Asp Phe Ala Cys 
        195                 200                 205             


Ala Asn Ala Phe Asn Asn Ser Ile Ile Pro Glu Asp Thr Phe Phe Pro 
    210                 215                 220                 


Ser Pro Glu Ser Ser Cys Asp Val Lys Leu Val Glu Lys Ser Phe Glu 
225                 230                 235                 240 


Thr Asp Thr Asn Leu Asn Phe Gln Asn Leu Ser Val Ile Gly Phe Arg 
                245                 250                 255     


Ile Leu Leu Leu Lys Val Ala Gly Phe Asn Leu Leu Met Thr Leu Arg 
            260                 265                 270         


Leu Trp Ser Ser 
        275     


<210> 24
<211> 936
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      polynucleotide

<400> 24
atgagcccaa ttttcacctg catcacaatc ctttgtctgc tggctgcagg ttctcctggt       60

gaagaagtcg cccagactcc aaaacatctt gtcagagggg aaggacagaa agcaaaactt      120

tattgtgccc caattaaagg acacagttat gttttctggt accaacaggt cctgaaaaac      180

gagttcaagt tcttgatttc cttccagaat gaaaatgtct ttgatgaaac aggtatgccc      240

aaggaaagat tttcagctaa gtgcctccca aattcaccct gtagccttga gatccaggct      300

actaagcttg aggattcagc agtgtatttt tgtgccagca gccaatcacg gagccttagg      360

ggcactgaag ctttctttgg acaaggcacc agactcacag ttgttgagga cctgaacaag      420

gtgttcccac ccgaggtcgc tgtgtttgag ccatcagaag cagagatctc ccacacccaa      480

aaggccacac tggtgtgcct ggccacaggc ttcttccctg accacgtgga gctgagctgg      540

tgggtgaatg ggaaggaggt gcacagtggg gtcagcacgg acccgcagcc cctcaaggag      600

cagcccgccc tcaatgactc cagatactgc ctgagcagcc gcctgagggt ctcggccacc      660

ttctggcaga acccccgcaa ccacttccgc tgtcaagtcc agttctacgg gctctcggag      720

aatgacgagt ggacccagga tagggccaaa cccgtcaccc agatcgtcag cgccgaggcc      780

tggggtagag cagactgtgg ctttacctcg gtgtcctacc agcaaggggt cctgtctgcc      840

accatcctct atgagatcct gctagggaag gccaccctgt atgctgtgct ggtcagcgcc      900

cttgtgttga tggccatggt caagagaaag gatttc                                936


<210> 25
<211> 312
<212> PRT
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      polypeptide

<400> 25
Met Ser Pro Ile Phe Thr Cys Ile Thr Ile Leu Cys Leu Leu Ala Ala 
1               5                   10                  15      


Gly Ser Pro Gly Glu Glu Val Ala Gln Thr Pro Lys His Leu Val Arg 
            20                  25                  30          


Gly Glu Gly Gln Lys Ala Lys Leu Tyr Cys Ala Pro Ile Lys Gly His 
        35                  40                  45              


Ser Tyr Val Phe Trp Tyr Gln Gln Val Leu Lys Asn Glu Phe Lys Phe 
    50                  55                  60                  


Leu Ile Ser Phe Gln Asn Glu Asn Val Phe Asp Glu Thr Gly Met Pro 
65                  70                  75                  80  


Lys Glu Arg Phe Ser Ala Lys Cys Leu Pro Asn Ser Pro Cys Ser Leu 
                85                  90                  95      


Glu Ile Gln Ala Thr Lys Leu Glu Asp Ser Ala Val Tyr Phe Cys Ala 
            100                 105                 110         


Ser Ser Gln Ser Arg Ser Leu Arg Gly Thr Glu Ala Phe Phe Gly Gln 
        115                 120                 125             


Gly Thr Arg Leu Thr Val Val Glu Asp Leu Asn Lys Val Phe Pro Pro 
    130                 135                 140                 


Glu Val Ala Val Phe Glu Pro Ser Glu Ala Glu Ile Ser His Thr Gln 
145                 150                 155                 160 


Lys Ala Thr Leu Val Cys Leu Ala Thr Gly Phe Phe Pro Asp His Val 
                165                 170                 175     


Glu Leu Ser Trp Trp Val Asn Gly Lys Glu Val His Ser Gly Val Ser 
            180                 185                 190         


Thr Asp Pro Gln Pro Leu Lys Glu Gln Pro Ala Leu Asn Asp Ser Arg 
        195                 200                 205             


Tyr Cys Leu Ser Ser Arg Leu Arg Val Ser Ala Thr Phe Trp Gln Asn 
    210                 215                 220                 


Pro Arg Asn His Phe Arg Cys Gln Val Gln Phe Tyr Gly Leu Ser Glu 
225                 230                 235                 240 


Asn Asp Glu Trp Thr Gln Asp Arg Ala Lys Pro Val Thr Gln Ile Val 
                245                 250                 255     


Ser Ala Glu Ala Trp Gly Arg Ala Asp Cys Gly Phe Thr Ser Val Ser 
            260                 265                 270         


Tyr Gln Gln Gly Val Leu Ser Ala Thr Ile Leu Tyr Glu Ile Leu Leu 
        275                 280                 285             


Gly Lys Ala Thr Leu Tyr Ala Val Leu Val Ser Ala Leu Val Leu Met 
    290                 295                 300                 


Ala Met Val Lys Arg Lys Asp Phe 
305                 310         


<210> 26
<211> 816
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      polynucleotide

<400> 26
atggagaaga atcctttggc agccccactt cttatcctct ggtttcatct tgactgcgtg       60

agcagcattc tgaacgtgga acaaagtcct cagtcactgc atgttcagga gggagacagc      120

accaatttca cctgcagctt cccttccagc aatttttatg cccttcactg gtacagatgg      180

gaaactgcaa aaagccccga ggccttgttt gttatgactc ttaatgggga tgaaaagaag      240

aaaggacgca ttagtgccac tcttaatacc aaggagggtt acagctattt gtatatcaaa      300

ggatcccagc ctgaggactc agccacatac ctctgtgcct ccggaagtgg tggtgctaca      360

aacaagctca tctttggaac tggcactctg cttgctgtcc agccaaacat tcaaaaccca      420

gaacccgccg tctaccagct gaaagacccg aggtctcaag actctacgtt gtgcttgttc      480

accgatttcg acagtcagat aaatgtgcct aagaccatgg agagtggcac tttcatcact      540

gacaaatgtg tgttggacat gaaggctatg gacagcaagt caaacggcgc gattgcttgg      600

tccaaccaaa cttctttcac gtgccaggac atcttcaagg agacaaacgc cacctatcca      660

tcctctgatg ttccgtgcga tgcgactctt accgagaaaa gcttcgagac ggacatgaac      720

ttgaacttcc aaaacctgct tgtgatggta ctgcgaatac ttcttcttaa ggtggcgggc      780

ttcaatttgc tcatgacact cagactttgg tctagc                                816


<210> 27
<211> 272
<212> PRT
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      polypeptide

<400> 27
Met Glu Lys Asn Pro Leu Ala Ala Pro Leu Leu Ile Leu Trp Phe His 
1               5                   10                  15      


Leu Asp Cys Val Ser Ser Ile Leu Asn Val Glu Gln Ser Pro Gln Ser 
            20                  25                  30          


Leu His Val Gln Glu Gly Asp Ser Thr Asn Phe Thr Cys Ser Phe Pro 
        35                  40                  45              


Ser Ser Asn Phe Tyr Ala Leu His Trp Tyr Arg Trp Glu Thr Ala Lys 
    50                  55                  60                  


Ser Pro Glu Ala Leu Phe Val Met Thr Leu Asn Gly Asp Glu Lys Lys 
65                  70                  75                  80  


Lys Gly Arg Ile Ser Ala Thr Leu Asn Thr Lys Glu Gly Tyr Ser Tyr 
                85                  90                  95      


Leu Tyr Ile Lys Gly Ser Gln Pro Glu Asp Ser Ala Thr Tyr Leu Cys 
            100                 105                 110         


Ala Ser Gly Ser Gly Gly Ala Thr Asn Lys Leu Ile Phe Gly Thr Gly 
        115                 120                 125             


Thr Leu Leu Ala Val Gln Pro Asn Ile Gln Asn Pro Glu Pro Ala Val 
    130                 135                 140                 


Tyr Gln Leu Lys Asp Pro Arg Ser Gln Asp Ser Thr Leu Cys Leu Phe 
145                 150                 155                 160 


Thr Asp Phe Asp Ser Gln Ile Asn Val Pro Lys Thr Met Glu Ser Gly 
                165                 170                 175     


Thr Phe Ile Thr Asp Lys Cys Val Leu Asp Met Lys Ala Met Asp Ser 
            180                 185                 190         


Lys Ser Asn Gly Ala Ile Ala Trp Ser Asn Gln Thr Ser Phe Thr Cys 
        195                 200                 205             


Gln Asp Ile Phe Lys Glu Thr Asn Ala Thr Tyr Pro Ser Ser Asp Val 
    210                 215                 220                 


Pro Cys Asp Ala Thr Leu Thr Glu Lys Ser Phe Glu Thr Asp Met Asn 
225                 230                 235                 240 


Leu Asn Phe Gln Asn Leu Leu Val Met Val Leu Arg Ile Leu Leu Leu 
                245                 250                 255     


Lys Val Ala Gly Phe Asn Leu Leu Met Thr Leu Arg Leu Trp Ser Ser 
            260                 265                 270         


<210> 28
<211> 924
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      polynucleotide

<400> 28
atgagcccaa ttttcacctg catcacaatc ctttgtctgc tggctgcagg ttctcctggt       60

gaagaagtcg cccagactcc aaaacatctt gtcagagggg aaggacagaa agcaaaactt      120

tattgtgccc caattaaagg acacagttat gttttctggt accaacaggt cctgaaaaac      180

gagttcaagt tcttgatttc cttccagaat gaaaatgtct ttgatgaaac aggtatgccc      240

aaggaaagat tttcagctaa gtgcctccca aattcaccct gtagccttga gatccaggct      300

actaagcttg aggattcagc agtgtatttt tgtgccagca gccaatcacg gagccttagg      360

ggcactgaag ctttctttgg acaaggcacc agactcacag ttgttgaaga tcttcgaaac      420

gtaacccctc caaaagtgag tctctttgaa ccgagtaagg ctgagatcgc gaacaaacaa      480

aaggcgaccc tcgtctgtct tgcgcgagga ttttttcccg accacgtgga gttgtcttgg      540

tgggtaaacg gtaaggaagt acacagcggt gtttgcaccg accctcaagc ctacaaggaa      600

tctaactatt catactgcct ttcatcccga cttagggttt ctgctacctt ttggcacaat      660

ccgaggaatc actttaggtg tcaagtacag ttccacggat tgtcagagga ggataaatgg      720

ccggagggct ccccgaagcc ggttacgcag aacattagtg cggaagcctg gggacgagca      780

gactgcggta tcacgtctgc cagctatcag caaggcgttc tgtcagcgac aattctgtac      840

gaaatacttt tgggtaaggc tacattgtat gcggtattgg tgtctacgct ggtagtcatg      900

gccatggtga aacgaaaaaa ctca                                             924


<210> 29
<211> 308
<212> PRT
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      polypeptide

<400> 29
Met Ser Pro Ile Phe Thr Cys Ile Thr Ile Leu Cys Leu Leu Ala Ala 
1               5                   10                  15      


Gly Ser Pro Gly Glu Glu Val Ala Gln Thr Pro Lys His Leu Val Arg 
            20                  25                  30          


Gly Glu Gly Gln Lys Ala Lys Leu Tyr Cys Ala Pro Ile Lys Gly His 
        35                  40                  45              


Ser Tyr Val Phe Trp Tyr Gln Gln Val Leu Lys Asn Glu Phe Lys Phe 
    50                  55                  60                  


Leu Ile Ser Phe Gln Asn Glu Asn Val Phe Asp Glu Thr Gly Met Pro 
65                  70                  75                  80  


Lys Glu Arg Phe Ser Ala Lys Cys Leu Pro Asn Ser Pro Cys Ser Leu 
                85                  90                  95      


Glu Ile Gln Ala Thr Lys Leu Glu Asp Ser Ala Val Tyr Phe Cys Ala 
            100                 105                 110         


Ser Ser Gln Ser Arg Ser Leu Arg Gly Thr Glu Ala Phe Phe Gly Gln 
        115                 120                 125             


Gly Thr Arg Leu Thr Val Val Glu Asp Leu Arg Asn Val Thr Pro Pro 
    130                 135                 140                 


Lys Val Ser Leu Phe Glu Pro Ser Lys Ala Glu Ile Ala Asn Lys Gln 
145                 150                 155                 160 


Lys Ala Thr Leu Val Cys Leu Ala Arg Gly Phe Phe Pro Asp His Val 
                165                 170                 175     


Glu Leu Ser Trp Trp Val Asn Gly Lys Glu Val His Ser Gly Val Cys 
            180                 185                 190         


Thr Asp Pro Gln Ala Tyr Lys Glu Ser Asn Tyr Ser Tyr Cys Leu Ser 
        195                 200                 205             


Ser Arg Leu Arg Val Ser Ala Thr Phe Trp His Asn Pro Arg Asn His 
    210                 215                 220                 


Phe Arg Cys Gln Val Gln Phe His Gly Leu Ser Glu Glu Asp Lys Trp 
225                 230                 235                 240 


Pro Glu Gly Ser Pro Lys Pro Val Thr Gln Asn Ile Ser Ala Glu Ala 
                245                 250                 255     


Trp Gly Arg Ala Asp Cys Gly Ile Thr Ser Ala Ser Tyr Gln Gln Gly 
            260                 265                 270         


Val Leu Ser Ala Thr Ile Leu Tyr Glu Ile Leu Leu Gly Lys Ala Thr 
        275                 280                 285             


Leu Tyr Ala Val Leu Val Ser Thr Leu Val Val Met Ala Met Val Lys 
    290                 295                 300                 


Arg Lys Asn Ser 
305             


<210> 30
<211> 1821
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      polynucleotide

<400> 30
atgagcccaa ttttcacctg catcacaatc ctttgtctgc tggctgcagg ttctcctggt       60

gaagaagtcg cccagactcc aaaacatctt gtcagagggg aaggacagaa agcaaaactt      120

tattgtgccc caattaaagg acacagttat gttttctggt accaacaggt cctgaaaaac      180

gagttcaagt tcttgatttc cttccagaat gaaaatgtct ttgatgaaac aggtatgccc      240

aaggaaagat tttcagctaa gtgcctccca aattcaccct gtagccttga gatccaggct      300

actaagcttg aggattcagc agtgtatttt tgtgccagca gccaatcacg gagccttagg      360

ggcactgaag ctttctttgg acaaggcacc agactcacag ttgttgaaga tcttcgaaac      420

gtaacccctc caaaagtgag tctctttgaa ccgagtaagg ctgagatcgc gaacaaacaa      480

aaggcgaccc tcgtctgtct tgcgcgagga ttttttcccg accacgtgga gttgtcttgg      540

tgggtaaacg gtaaggaagt acacagcggt gtttgcaccg accctcaagc ctacaaggaa      600

tctaactatt catactgcct ttcatcccga cttagggttt ctgctacctt ttggcacaat      660

ccgaggaatc actttaggtg tcaagtacag ttccacggat tgtcagagga ggataaatgg      720

ccggagggct ccccgaagcc ggttacgcag aacattagtg cggaagcctg gggacgagca      780

gactgcggta tcacgtctgc cagctatcag caaggcgttc tgtcagcgac aattctgtac      840

gaaatacttt tgggtaaggc tacattgtat gcggtattgg tgtctacgct ggtagtcatg      900

gccatggtga aacgaaaaaa ctcaagagcc aaaagaagcg ggagcggtgc gacaaacttt      960

agcctgttga aacaagccgg cgacgttgaa gagaaccccg gacctatgga gaagaatcct     1020

ttggcagccc cacttcttat cctctggttt catcttgact gcgtgagcag cattctgaac     1080

gtggaacaaa gtcctcagtc actgcatgtt caggagggag acagcaccaa tttcacctgc     1140

agcttccctt ccagcaattt ttatgccctt cactggtaca gatgggaaac tgcaaaaagc     1200

cccgaggcct tgtttgttat gactcttaat ggggatgaaa agaagaaagg acgcattagt     1260

gccactctta ataccaagga gggttacagc tatttgtata tcaaaggatc ccagcctgag     1320

gactcagcca catacctctg tgcctccgga agtggtggtg ctacaaacaa gctcatcttt     1380

ggaactggca ctctgcttgc tgtccagcca aacattcaaa acccagaacc cgccgtctac     1440

cagctgaaag acccgaggtc tcaagactct acgttgtgct tgttcaccga tttcgacagt     1500

cagataaatg tgcctaagac catggagagt ggcactttca tcactgacaa atgtgtgttg     1560

gacatgaagg ctatggacag caagtcaaac ggcgcgattg cttggtccaa ccaaacttct     1620

ttcacgtgcc aggacatctt caaggagaca aacgccacct atccatcctc tgatgttccg     1680

tgcgatgcga ctcttaccga gaaaagcttc gagacggaca tgaacttgaa cttccaaaac     1740

ctgcttgtga tggtactgcg aatacttctt cttaaggtgg cgggcttcaa tttgctcatg     1800

acactcagac tttggtctag c                                               1821


<210> 31
<211> 607
<212> PRT
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      polypeptide

<400> 31
Met Ser Pro Ile Phe Thr Cys Ile Thr Ile Leu Cys Leu Leu Ala Ala 
1               5                   10                  15      


Gly Ser Pro Gly Glu Glu Val Ala Gln Thr Pro Lys His Leu Val Arg 
            20                  25                  30          


Gly Glu Gly Gln Lys Ala Lys Leu Tyr Cys Ala Pro Ile Lys Gly His 
        35                  40                  45              


Ser Tyr Val Phe Trp Tyr Gln Gln Val Leu Lys Asn Glu Phe Lys Phe 
    50                  55                  60                  


Leu Ile Ser Phe Gln Asn Glu Asn Val Phe Asp Glu Thr Gly Met Pro 
65                  70                  75                  80  


Lys Glu Arg Phe Ser Ala Lys Cys Leu Pro Asn Ser Pro Cys Ser Leu 
                85                  90                  95      


Glu Ile Gln Ala Thr Lys Leu Glu Asp Ser Ala Val Tyr Phe Cys Ala 
            100                 105                 110         


Ser Ser Gln Ser Arg Ser Leu Arg Gly Thr Glu Ala Phe Phe Gly Gln 
        115                 120                 125             


Gly Thr Arg Leu Thr Val Val Glu Asp Leu Arg Asn Val Thr Pro Pro 
    130                 135                 140                 


Lys Val Ser Leu Phe Glu Pro Ser Lys Ala Glu Ile Ala Asn Lys Gln 
145                 150                 155                 160 


Lys Ala Thr Leu Val Cys Leu Ala Arg Gly Phe Phe Pro Asp His Val 
                165                 170                 175     


Glu Leu Ser Trp Trp Val Asn Gly Lys Glu Val His Ser Gly Val Cys 
            180                 185                 190         


Thr Asp Pro Gln Ala Tyr Lys Glu Ser Asn Tyr Ser Tyr Cys Leu Ser 
        195                 200                 205             


Ser Arg Leu Arg Val Ser Ala Thr Phe Trp His Asn Pro Arg Asn His 
    210                 215                 220                 


Phe Arg Cys Gln Val Gln Phe His Gly Leu Ser Glu Glu Asp Lys Trp 
225                 230                 235                 240 


Pro Glu Gly Ser Pro Lys Pro Val Thr Gln Asn Ile Ser Ala Glu Ala 
                245                 250                 255     


Trp Gly Arg Ala Asp Cys Gly Ile Thr Ser Ala Ser Tyr Gln Gln Gly 
            260                 265                 270         


Val Leu Ser Ala Thr Ile Leu Tyr Glu Ile Leu Leu Gly Lys Ala Thr 
        275                 280                 285             


Leu Tyr Ala Val Leu Val Ser Thr Leu Val Val Met Ala Met Val Lys 
    290                 295                 300                 


Arg Lys Asn Ser Arg Ala Lys Arg Ser Gly Ser Gly Ala Thr Asn Phe 
305                 310                 315                 320 


Ser Leu Leu Lys Gln Ala Gly Asp Val Glu Glu Asn Pro Gly Pro Met 
                325                 330                 335     


Glu Lys Asn Pro Leu Ala Ala Pro Leu Leu Ile Leu Trp Phe His Leu 
            340                 345                 350         


Asp Cys Val Ser Ser Ile Leu Asn Val Glu Gln Ser Pro Gln Ser Leu 
        355                 360                 365             


His Val Gln Glu Gly Asp Ser Thr Asn Phe Thr Cys Ser Phe Pro Ser 
    370                 375                 380                 


Ser Asn Phe Tyr Ala Leu His Trp Tyr Arg Trp Glu Thr Ala Lys Ser 
385                 390                 395                 400 


Pro Glu Ala Leu Phe Val Met Thr Leu Asn Gly Asp Glu Lys Lys Lys 
                405                 410                 415     


Gly Arg Ile Ser Ala Thr Leu Asn Thr Lys Glu Gly Tyr Ser Tyr Leu 
            420                 425                 430         


Tyr Ile Lys Gly Ser Gln Pro Glu Asp Ser Ala Thr Tyr Leu Cys Ala 
        435                 440                 445             


Ser Gly Ser Gly Gly Ala Thr Asn Lys Leu Ile Phe Gly Thr Gly Thr 
    450                 455                 460                 


Leu Leu Ala Val Gln Pro Asn Ile Gln Asn Pro Glu Pro Ala Val Tyr 
465                 470                 475                 480 


Gln Leu Lys Asp Pro Arg Ser Gln Asp Ser Thr Leu Cys Leu Phe Thr 
                485                 490                 495     


Asp Phe Asp Ser Gln Ile Asn Val Pro Lys Thr Met Glu Ser Gly Thr 
            500                 505                 510         


Phe Ile Thr Asp Lys Cys Val Leu Asp Met Lys Ala Met Asp Ser Lys 
        515                 520                 525             


Ser Asn Gly Ala Ile Ala Trp Ser Asn Gln Thr Ser Phe Thr Cys Gln 
    530                 535                 540                 


Asp Ile Phe Lys Glu Thr Asn Ala Thr Tyr Pro Ser Ser Asp Val Pro 
545                 550                 555                 560 


Cys Asp Ala Thr Leu Thr Glu Lys Ser Phe Glu Thr Asp Met Asn Leu 
                565                 570                 575     


Asn Phe Gln Asn Leu Leu Val Met Val Leu Arg Ile Leu Leu Leu Lys 
            580                 585                 590         


Val Ala Gly Phe Asn Leu Leu Met Thr Leu Arg Leu Trp Ser Ser 
        595                 600                 605         


<210> 32
<211> 828
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      polynucleotide

<400> 32
atggagaaga atcctttggc agccccactt cttatcctct ggtttcatct tgactgcgtg       60

agcagcattc tgaacgtgga acaaagtcct cagtcactgc atgttcagga gggagacagc      120

accaatttca cctgcagctt cccttccagc aatttttatg cccttcactg gtacagatgg      180

gaaactgcaa aaagccccga ggccttgttt gttatgactc ttaatgggga tgaaaagaag      240

aaaggacgca ttagtgccac tcttaatacc aaggagggtt acagctattt gtatatcaaa      300

ggatcccagc ctgaggactc agccacatac ctctgtgcct ccggaagtgg tggtgctaca      360

aacaagctca tctttggaac tggcactctg cttgctgtcc agccaaacat ccagaacccc      420

gaccccgccg tgtaccagct gagggactcc aagtccagcg acaagagcgt gtgtctgttt      480

acggacttcg acagccagac caacgtgagt caaagcaagg acagcgacgt ctacataacg      540

gataagaccg tgctggacat gcggagcatg gacttcaaga gcaacagcgc cgtggcctgg      600

tccaacaaga gcgacttcgc ctgcgccaac gccttcaaca acagcatcat ccccgaggac      660

accttcttcc ccagcagcga cgtgccctgc gacgtgaaac tggtggagaa gtccttcgag      720

acagacacca atctgaactt tcagaacctg ctggtgatcg tgctgcggat tctgctgctg      780

aaagtggccg gcttcaatct gctgatgacc ctgcggctgt ggagcagc                   828


<210> 33
<211> 276
<212> PRT
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      polypeptide

<400> 33
Met Glu Lys Asn Pro Leu Ala Ala Pro Leu Leu Ile Leu Trp Phe His 
1               5                   10                  15      


Leu Asp Cys Val Ser Ser Ile Leu Asn Val Glu Gln Ser Pro Gln Ser 
            20                  25                  30          


Leu His Val Gln Glu Gly Asp Ser Thr Asn Phe Thr Cys Ser Phe Pro 
        35                  40                  45              


Ser Ser Asn Phe Tyr Ala Leu His Trp Tyr Arg Trp Glu Thr Ala Lys 
    50                  55                  60                  


Ser Pro Glu Ala Leu Phe Val Met Thr Leu Asn Gly Asp Glu Lys Lys 
65                  70                  75                  80  


Lys Gly Arg Ile Ser Ala Thr Leu Asn Thr Lys Glu Gly Tyr Ser Tyr 
                85                  90                  95      


Leu Tyr Ile Lys Gly Ser Gln Pro Glu Asp Ser Ala Thr Tyr Leu Cys 
            100                 105                 110         


Ala Ser Gly Ser Gly Gly Ala Thr Asn Lys Leu Ile Phe Gly Thr Gly 
        115                 120                 125             


Thr Leu Leu Ala Val Gln Pro Asn Ile Gln Asn Pro Asp Pro Ala Val 
    130                 135                 140                 


Tyr Gln Leu Arg Asp Ser Lys Ser Ser Asp Lys Ser Val Cys Leu Phe 
145                 150                 155                 160 


Thr Asp Phe Asp Ser Gln Thr Asn Val Ser Gln Ser Lys Asp Ser Asp 
                165                 170                 175     


Val Tyr Ile Thr Asp Lys Thr Val Leu Asp Met Arg Ser Met Asp Phe 
            180                 185                 190         


Lys Ser Asn Ser Ala Val Ala Trp Ser Asn Lys Ser Asp Phe Ala Cys 
        195                 200                 205             


Ala Asn Ala Phe Asn Asn Ser Ile Ile Pro Glu Asp Thr Phe Phe Pro 
    210                 215                 220                 


Ser Ser Asp Val Pro Cys Asp Val Lys Leu Val Glu Lys Ser Phe Glu 
225                 230                 235                 240 


Thr Asp Thr Asn Leu Asn Phe Gln Asn Leu Leu Val Ile Val Leu Arg 
                245                 250                 255     


Ile Leu Leu Leu Lys Val Ala Gly Phe Asn Leu Leu Met Thr Leu Arg 
            260                 265                 270         


Leu Trp Ser Ser 
        275     


<210> 34
<211> 936
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      polynucleotide

<400> 34
atgagcccaa ttttcacctg catcacaatc ctttgtctgc tggctgcagg ttctcctggt       60

gaagaagtcg cccagactcc aaaacatctt gtcagagggg aaggacagaa agcaaaactt      120

tattgtgccc caattaaagg acacagttat gttttctggt accaacaggt cctgaaaaac      180

gagttcaagt tcttgatttc cttccagaat gaaaatgtct ttgatgaaac aggtatgccc      240

aaggaaagat tttcagctaa gtgcctccca aattcaccct gtagccttga gatccaggct      300

actaagcttg aggattcagc agtgtatttt tgtgccagca gccaatcacg gagccttagg      360

ggcactgaag ctttctttgg acaaggcacc agactcacag ttgttgaaga tctgaacaag      420

gtgttccctc cagaggtggc cgtgttcgag ccttctaagg ccgagatcgc ccacacacaa      480

aaagccaccc tcgtgtgcct ggccaccggc tttttccccg accacgtgga actgtcttgg      540

tgggtcaacg gcaaagaggt gcactccggc gtgtcaacgg atccccagcc tctgaaagaa      600

cagcctgccc tgaacgacag ccggtactgc ctgagctcca gactgagagt gtccgccacc      660

ttctggcaga acccccggaa ccacttcaga tgccaggtgc agttttacgg cctgagcgag      720

aacgacgagt ggacccagga cagagccaag cccgtgacac aaatcgtgtc tgccgaagcc      780

tggggaagag ccgattgcgg catcaccagc gcctcctatc accagggcgt gctgagcgcc      840

acaatcctgt acgaaatcct gctgggcaag gccaccctgt acgccgtgct ggtgtctgct      900

ctggtgctga tggccatggt caagcggaag gacttt                                936


<210> 35
<211> 312
<212> PRT
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      polypeptide

<400> 35
Met Ser Pro Ile Phe Thr Cys Ile Thr Ile Leu Cys Leu Leu Ala Ala 
1               5                   10                  15      


Gly Ser Pro Gly Glu Glu Val Ala Gln Thr Pro Lys His Leu Val Arg 
            20                  25                  30          


Gly Glu Gly Gln Lys Ala Lys Leu Tyr Cys Ala Pro Ile Lys Gly His 
        35                  40                  45              


Ser Tyr Val Phe Trp Tyr Gln Gln Val Leu Lys Asn Glu Phe Lys Phe 
    50                  55                  60                  


Leu Ile Ser Phe Gln Asn Glu Asn Val Phe Asp Glu Thr Gly Met Pro 
65                  70                  75                  80  


Lys Glu Arg Phe Ser Ala Lys Cys Leu Pro Asn Ser Pro Cys Ser Leu 
                85                  90                  95      


Glu Ile Gln Ala Thr Lys Leu Glu Asp Ser Ala Val Tyr Phe Cys Ala 
            100                 105                 110         


Ser Ser Gln Ser Arg Ser Leu Arg Gly Thr Glu Ala Phe Phe Gly Gln 
        115                 120                 125             


Gly Thr Arg Leu Thr Val Val Glu Asp Leu Asn Lys Val Phe Pro Pro 
    130                 135                 140                 


Glu Val Ala Val Phe Glu Pro Ser Lys Ala Glu Ile Ala His Thr Gln 
145                 150                 155                 160 


Lys Ala Thr Leu Val Cys Leu Ala Thr Gly Phe Phe Pro Asp His Val 
                165                 170                 175     


Glu Leu Ser Trp Trp Val Asn Gly Lys Glu Val His Ser Gly Val Ser 
            180                 185                 190         


Thr Asp Pro Gln Pro Leu Lys Glu Gln Pro Ala Leu Asn Asp Ser Arg 
        195                 200                 205             


Tyr Cys Leu Ser Ser Arg Leu Arg Val Ser Ala Thr Phe Trp Gln Asn 
    210                 215                 220                 


Pro Arg Asn His Phe Arg Cys Gln Val Gln Phe Tyr Gly Leu Ser Glu 
225                 230                 235                 240 


Asn Asp Glu Trp Thr Gln Asp Arg Ala Lys Pro Val Thr Gln Ile Val 
                245                 250                 255     


Ser Ala Glu Ala Trp Gly Arg Ala Asp Cys Gly Ile Thr Ser Ala Ser 
            260                 265                 270         


Tyr His Gln Gly Val Leu Ser Ala Thr Ile Leu Tyr Glu Ile Leu Leu 
        275                 280                 285             


Gly Lys Ala Thr Leu Tyr Ala Val Leu Val Ser Ala Leu Val Leu Met 
    290                 295                 300                 


Ala Met Val Lys Arg Lys Asp Phe 
305                 310         


<210> 36
<211> 1854
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      polynucleotide

<400> 36
atgagcccaa ttttcacctg catcacaatc ctttgtctgc tggctgcagg ttctcctggt       60

gaagaagtcg cccagactcc aaaacatctt gtcagagggg aaggacagaa agcaaaactt      120

tattgtgccc caattaaagg acacagttat gttttctggt accaacaggt cctgaaaaac      180

gagttcaagt tcttgatttc cttccagaat gaaaatgtct ttgatgaaac aggtatgccc      240

aaggaaagat tttcagctaa gtgcctccca aattcaccct gtagccttga gatccaggct      300

actaagcttg aggattcagc agtgtatttt tgtgccagca gccaatcacg gagccttagg      360

ggcactgaag ctttctttgg acaaggcacc agactcacag ttgttgaaga tctgaacaag      420

gtgttccctc cagaggtggc cgtgttcgag ccttctaagg ccgagatcgc ccacacacaa      480

aaagccaccc tcgtgtgcct ggccaccggc tttttccccg accacgtgga actgtcttgg      540

tgggtcaacg gcaaagaggt gcactccggc gtgtcaacgg atccccagcc tctgaaagaa      600

cagcctgccc tgaacgacag ccggtactgc ctgagctcca gactgagagt gtccgccacc      660

ttctggcaga acccccggaa ccacttcaga tgccaggtgc agttttacgg cctgagcgag      720

aacgacgagt ggacccagga cagagccaag cccgtgacac aaatcgtgtc tgccgaagcc      780

tggggaagag ccgattgcgg catcaccagc gcctcctatc accagggcgt gctgagcgcc      840

acaatcctgt acgaaatcct gctgggcaag gccaccctgt acgccgtgct ggtgtctgct      900

ctggtgctga tggccatggt caagcggaag gactttggca gcggcagagc caaaagaagc      960

gggagcggtg cgacaaactt tagcctgttg aaacaagccg gcgacgttga agagaacccc     1020

ggacctatgg agaagaatcc tttggcagcc ccacttctta tcctctggtt tcatcttgac     1080

tgcgtgagca gcattctgaa cgtggaacaa agtcctcagt cactgcatgt tcaggaggga     1140

gacagcacca atttcacctg cagcttccct tccagcaatt tttatgccct tcactggtac     1200

agatgggaaa ctgcaaaaag ccccgaggcc ttgtttgtta tgactcttaa tggggatgaa     1260

aagaagaaag gacgcattag tgccactctt aataccaagg agggttacag ctatttgtat     1320

atcaaaggat cccagcctga ggactcagcc acatacctct gtgcctccgg aagtggtggt     1380

gctacaaaca agctcatctt tggaactggc actctgcttg ctgtccagcc aaacatccag     1440

aaccccgacc ccgccgtgta ccagctgagg gactccaagt ccagcgacaa gagcgtgtgt     1500

ctgtttacgg acttcgacag ccagaccaac gtgagtcaaa gcaaggacag cgacgtctac     1560

ataacggata agaccgtgct ggacatgcgg agcatggact tcaagagcaa cagcgccgtg     1620

gcctggtcca acaagagcga cttcgcctgc gccaacgcct tcaacaacag catcatcccc     1680

gaggacacct tcttccccag cagcgacgtg ccctgcgacg tgaaactggt ggagaagtcc     1740

ttcgagacag acaccaatct gaactttcag aacctgctgg tgatcgtgct gcggattctg     1800

ctgctgaaag tggccggctt caatctgctg atgaccctgc ggctgtggag cagc           1854


<210> 37
<211> 618
<212> PRT
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      polypeptide

<400> 37
Met Ser Pro Ile Phe Thr Cys Ile Thr Ile Leu Cys Leu Leu Ala Ala 
1               5                   10                  15      


Gly Ser Pro Gly Glu Glu Val Ala Gln Thr Pro Lys His Leu Val Arg 
            20                  25                  30          


Gly Glu Gly Gln Lys Ala Lys Leu Tyr Cys Ala Pro Ile Lys Gly His 
        35                  40                  45              


Ser Tyr Val Phe Trp Tyr Gln Gln Val Leu Lys Asn Glu Phe Lys Phe 
    50                  55                  60                  


Leu Ile Ser Phe Gln Asn Glu Asn Val Phe Asp Glu Thr Gly Met Pro 
65                  70                  75                  80  


Lys Glu Arg Phe Ser Ala Lys Cys Leu Pro Asn Ser Pro Cys Ser Leu 
                85                  90                  95      


Glu Ile Gln Ala Thr Lys Leu Glu Asp Ser Ala Val Tyr Phe Cys Ala 
            100                 105                 110         


Ser Ser Gln Ser Arg Ser Leu Arg Gly Thr Glu Ala Phe Phe Gly Gln 
        115                 120                 125             


Gly Thr Arg Leu Thr Val Val Glu Asp Leu Asn Lys Val Phe Pro Pro 
    130                 135                 140                 


Glu Val Ala Val Phe Glu Pro Ser Lys Ala Glu Ile Ala His Thr Gln 
145                 150                 155                 160 


Lys Ala Thr Leu Val Cys Leu Ala Thr Gly Phe Phe Pro Asp His Val 
                165                 170                 175     


Glu Leu Ser Trp Trp Val Asn Gly Lys Glu Val His Ser Gly Val Ser 
            180                 185                 190         


Thr Asp Pro Gln Pro Leu Lys Glu Gln Pro Ala Leu Asn Asp Ser Arg 
        195                 200                 205             


Tyr Cys Leu Ser Ser Arg Leu Arg Val Ser Ala Thr Phe Trp Gln Asn 
    210                 215                 220                 


Pro Arg Asn His Phe Arg Cys Gln Val Gln Phe Tyr Gly Leu Ser Glu 
225                 230                 235                 240 


Asn Asp Glu Trp Thr Gln Asp Arg Ala Lys Pro Val Thr Gln Ile Val 
                245                 250                 255     


Ser Ala Glu Ala Trp Gly Arg Ala Asp Cys Gly Ile Thr Ser Ala Ser 
            260                 265                 270         


Tyr His Gln Gly Val Leu Ser Ala Thr Ile Leu Tyr Glu Ile Leu Leu 
        275                 280                 285             


Gly Lys Ala Thr Leu Tyr Ala Val Leu Val Ser Ala Leu Val Leu Met 
    290                 295                 300                 


Ala Met Val Lys Arg Lys Asp Phe Gly Ser Gly Arg Ala Lys Arg Ser 
305                 310                 315                 320 


Gly Ser Gly Ala Thr Asn Phe Ser Leu Leu Lys Gln Ala Gly Asp Val 
                325                 330                 335     


Glu Glu Asn Pro Gly Pro Met Glu Lys Asn Pro Leu Ala Ala Pro Leu 
            340                 345                 350         


Leu Ile Leu Trp Phe His Leu Asp Cys Val Ser Ser Ile Leu Asn Val 
        355                 360                 365             


Glu Gln Ser Pro Gln Ser Leu His Val Gln Glu Gly Asp Ser Thr Asn 
    370                 375                 380                 


Phe Thr Cys Ser Phe Pro Ser Ser Asn Phe Tyr Ala Leu His Trp Tyr 
385                 390                 395                 400 


Arg Trp Glu Thr Ala Lys Ser Pro Glu Ala Leu Phe Val Met Thr Leu 
                405                 410                 415     


Asn Gly Asp Glu Lys Lys Lys Gly Arg Ile Ser Ala Thr Leu Asn Thr 
            420                 425                 430         


Lys Glu Gly Tyr Ser Tyr Leu Tyr Ile Lys Gly Ser Gln Pro Glu Asp 
        435                 440                 445             


Ser Ala Thr Tyr Leu Cys Ala Ser Gly Ser Gly Gly Ala Thr Asn Lys 
    450                 455                 460                 


Leu Ile Phe Gly Thr Gly Thr Leu Leu Ala Val Gln Pro Asn Ile Gln 
465                 470                 475                 480 


Asn Pro Asp Pro Ala Val Tyr Gln Leu Arg Asp Ser Lys Ser Ser Asp 
                485                 490                 495     


Lys Ser Val Cys Leu Phe Thr Asp Phe Asp Ser Gln Thr Asn Val Ser 
            500                 505                 510         


Gln Ser Lys Asp Ser Asp Val Tyr Ile Thr Asp Lys Thr Val Leu Asp 
        515                 520                 525             


Met Arg Ser Met Asp Phe Lys Ser Asn Ser Ala Val Ala Trp Ser Asn 
    530                 535                 540                 


Lys Ser Asp Phe Ala Cys Ala Asn Ala Phe Asn Asn Ser Ile Ile Pro 
545                 550                 555                 560 


Glu Asp Thr Phe Phe Pro Ser Ser Asp Val Pro Cys Asp Val Lys Leu 
                565                 570                 575     


Val Glu Lys Ser Phe Glu Thr Asp Thr Asn Leu Asn Phe Gln Asn Leu 
            580                 585                 590         


Leu Val Ile Val Leu Arg Ile Leu Leu Leu Lys Val Ala Gly Phe Asn 
        595                 600                 605             


Leu Leu Met Thr Leu Arg Leu Trp Ser Ser 
    610                 615             


<210> 38
<211> 825
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      polynucleotide

<400> 38
atgaaaaagc atctgacgac cttcttggtg attttgtggc tttattttta tagggggaat       60

ggcaaaaacc aagtggagca gagtcctcag tccctgatca tcctggaggg aaagaactgc      120

actcttcaat gcaattatac agtgagcccc ttcagcaact taaggtggta taagcaagat      180

acggggagag gtcctgtttc cctgacaatc atgactttca gtgagaacac aaagtcgaac      240

ggaagatata cagcaactct ggatgcagac acaaagcaaa gctctctgca catcacagcc      300

tcccagctca gcgattcagc ctcctacatc tgcgtcgtgt ctgcccgcaa cgcaggtaac      360

atgcttacat tcggaggggg aacaaggtta atggtcaaac cccatatcca gaaccctgac      420

cctgccgtgt accagctgag agactctaaa tccagtgaca agtctgtctg cctattcacc      480

gattttgatt ctcaaacaaa tgtgtcacaa agtaaggatt ctgatgtgta tatcacagac      540

aaaactgtgc tagacatgag gtctatggac ttcaagagca acagtgctgt ggcctggagc      600

aacaaatctg actttgcatg tgcaaacgcc ttcaacaaca gcattattcc agaagacacc      660

ttcttcccca gcccagaaag ttcctgtgat gtcaagctgg tcgagaaaag ctttgaaaca      720

gatacgaacc taaactttca aaacctgtca gtgattgggt tccgaatcct cctcctgaaa      780

gtggccgggt ttaatctgct catgacgctg cggctgtggt ccagc                      825


<210> 39
<211> 275
<212> PRT
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      polypeptide

<400> 39
Met Lys Lys His Leu Thr Thr Phe Leu Val Ile Leu Trp Leu Tyr Phe 
1               5                   10                  15      


Tyr Arg Gly Asn Gly Lys Asn Gln Val Glu Gln Ser Pro Gln Ser Leu 
            20                  25                  30          


Ile Ile Leu Glu Gly Lys Asn Cys Thr Leu Gln Cys Asn Tyr Thr Val 
        35                  40                  45              


Ser Pro Phe Ser Asn Leu Arg Trp Tyr Lys Gln Asp Thr Gly Arg Gly 
    50                  55                  60                  


Pro Val Ser Leu Thr Ile Met Thr Phe Ser Glu Asn Thr Lys Ser Asn 
65                  70                  75                  80  


Gly Arg Tyr Thr Ala Thr Leu Asp Ala Asp Thr Lys Gln Ser Ser Leu 
                85                  90                  95      


His Ile Thr Ala Ser Gln Leu Ser Asp Ser Ala Ser Tyr Ile Cys Val 
            100                 105                 110         


Val Ser Ala Arg Asn Ala Gly Asn Met Leu Thr Phe Gly Gly Gly Thr 
        115                 120                 125             


Arg Leu Met Val Lys Pro His Ile Gln Asn Pro Asp Pro Ala Val Tyr 
    130                 135                 140                 


Gln Leu Arg Asp Ser Lys Ser Ser Asp Lys Ser Val Cys Leu Phe Thr 
145                 150                 155                 160 


Asp Phe Asp Ser Gln Thr Asn Val Ser Gln Ser Lys Asp Ser Asp Val 
                165                 170                 175     


Tyr Ile Thr Asp Lys Thr Val Leu Asp Met Arg Ser Met Asp Phe Lys 
            180                 185                 190         


Ser Asn Ser Ala Val Ala Trp Ser Asn Lys Ser Asp Phe Ala Cys Ala 
        195                 200                 205             


Asn Ala Phe Asn Asn Ser Ile Ile Pro Glu Asp Thr Phe Phe Pro Ser 
    210                 215                 220                 


Pro Glu Ser Ser Cys Asp Val Lys Leu Val Glu Lys Ser Phe Glu Thr 
225                 230                 235                 240 


Asp Thr Asn Leu Asn Phe Gln Asn Leu Ser Val Ile Gly Phe Arg Ile 
                245                 250                 255     


Leu Leu Leu Lys Val Ala Gly Phe Asn Leu Leu Met Thr Leu Arg Leu 
            260                 265                 270         


Trp Ser Ser 
        275 


<210> 40
<211> 936
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      polynucleotide

<400> 40
atgggccccc agctccttgg ctatgtggtc ctttgccttc taggagcagg ccccctggaa       60

gcccaagtga cccagaaccc aagatacctc atcacagtga ctggaaagaa gttaacagtg      120

acttgttctc agaatatgaa ccatgagtat atgtcctggt atcgacaaga cccagggctg      180

ggcttaaggc agatctacta ttcaatgaat gttgaggtga ctgataaggg agatgttcct      240

gaagggtaca aagtctctcg aaaagagaag aggaatttcc ccctgatcct ggagtcgccc      300

agccccaacc agacctctct gtacttctgt gcctgcgcta gtagcttcgg caccagcggt      360

cgcggtgaac agtttttcgg gccagggaca cggctcaccg tgctagagga cctgaacaag      420

gtgttcccac ccgaggtcgc tgtgtttgag ccatcagaag cagagatctc ccacacccaa      480

aaggccacac tggtgtgcct ggccacaggc ttcttccctg accacgtgga gctgagctgg      540

tgggtgaatg ggaaggaggt gcacagtggg gtcagcacgg acccgcagcc cctcaaggag      600

cagcccgccc tcaatgactc cagatactgc ctgagcagcc gcctgagggt ctcggccacc      660

ttctggcaga acccccgcaa ccacttccgc tgtcaagtcc agttctacgg gctctcggag      720

aatgacgagt ggacccagga tagggccaaa cccgtcaccc agatcgtcag cgccgaggcc      780

tggggtagag cagactgtgg ctttacctcg gtgtcctacc agcaaggggt cctgtctgcc      840

accatcctct atgagatcct gctagggaag gccaccctgt atgctgtgct ggtcagcgcc      900

cttgtgttga tggccatggt caagagaaag gatttc                                936


<210> 41
<211> 312
<212> PRT
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      polypeptide

<400> 41
Met Gly Pro Gln Leu Leu Gly Tyr Val Val Leu Cys Leu Leu Gly Ala 
1               5                   10                  15      


Gly Pro Leu Glu Ala Gln Val Thr Gln Asn Pro Arg Tyr Leu Ile Thr 
            20                  25                  30          


Val Thr Gly Lys Lys Leu Thr Val Thr Cys Ser Gln Asn Met Asn His 
        35                  40                  45              


Glu Tyr Met Ser Trp Tyr Arg Gln Asp Pro Gly Leu Gly Leu Arg Gln 
    50                  55                  60                  


Ile Tyr Tyr Ser Met Asn Val Glu Val Thr Asp Lys Gly Asp Val Pro 
65                  70                  75                  80  


Glu Gly Tyr Lys Val Ser Arg Lys Glu Lys Arg Asn Phe Pro Leu Ile 
                85                  90                  95      


Leu Glu Ser Pro Ser Pro Asn Gln Thr Ser Leu Tyr Phe Cys Ala Cys 
            100                 105                 110         


Ala Ser Ser Phe Gly Thr Ser Gly Arg Gly Glu Gln Phe Phe Gly Pro 
        115                 120                 125             


Gly Thr Arg Leu Thr Val Leu Glu Asp Leu Asn Lys Val Phe Pro Pro 
    130                 135                 140                 


Glu Val Ala Val Phe Glu Pro Ser Glu Ala Glu Ile Ser His Thr Gln 
145                 150                 155                 160 


Lys Ala Thr Leu Val Cys Leu Ala Thr Gly Phe Phe Pro Asp His Val 
                165                 170                 175     


Glu Leu Ser Trp Trp Val Asn Gly Lys Glu Val His Ser Gly Val Ser 
            180                 185                 190         


Thr Asp Pro Gln Pro Leu Lys Glu Gln Pro Ala Leu Asn Asp Ser Arg 
        195                 200                 205             


Tyr Cys Leu Ser Ser Arg Leu Arg Val Ser Ala Thr Phe Trp Gln Asn 
    210                 215                 220                 


Pro Arg Asn His Phe Arg Cys Gln Val Gln Phe Tyr Gly Leu Ser Glu 
225                 230                 235                 240 


Asn Asp Glu Trp Thr Gln Asp Arg Ala Lys Pro Val Thr Gln Ile Val 
                245                 250                 255     


Ser Ala Glu Ala Trp Gly Arg Ala Asp Cys Gly Phe Thr Ser Val Ser 
            260                 265                 270         


Tyr Gln Gln Gly Val Leu Ser Ala Thr Ile Leu Tyr Glu Ile Leu Leu 
        275                 280                 285             


Gly Lys Ala Thr Leu Tyr Ala Val Leu Val Ser Ala Leu Val Leu Met 
    290                 295                 300                 


Ala Met Val Lys Arg Lys Asp Phe 
305                 310         


<210> 42
<211> 813
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      polynucleotide

<400> 42
atgaaaaagc atctgacgac cttcttggtg attttgtggc tttattttta tagggggaat       60

ggcaaaaacc aagtggagca gagtcctcag tccctgatca tcctggaggg aaagaactgc      120

actcttcaat gcaattatac agtgagcccc ttcagcaact taaggtggta taagcaagat      180

acggggagag gtcctgtttc cctgacaatc atgactttca gtgagaacac aaagtcgaac      240

ggaagatata cagcaactct ggatgcagac acaaagcaaa gctctctgca catcacagcc      300

tcccagctca gcgattcagc ctcctacatc tgcgtcgtgt ctgcccgcaa cgcaggtaac      360

atgcttacat tcggaggggg aacaaggtta atggtcaaac cccatattca aaacccagaa      420

cccgccgtct accagctgaa agacccgagg tctcaagact ctacgttgtg cttgttcacc      480

gatttcgaca gtcagataaa tgtgcctaag accatggaga gtggcacttt catcactgac      540

aaatgtgtgt tggacatgaa ggctatggac agcaagtcaa acggcgcgat tgcttggtcc      600

aaccaaactt ctttcacgtg ccaggacatc ttcaaggaga caaacgccac ctatccatcc      660

tctgatgttc cgtgcgatgc gactcttacc gagaaaagct tcgagacgga catgaacttg      720

aacttccaaa acctgcttgt gatggtactg cgaatacttc ttcttaaggt ggcgggcttc      780

aatttgctca tgacactcag actttggtct agc                                   813


<210> 43
<211> 271
<212> PRT
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      polypeptide

<400> 43
Met Lys Lys His Leu Thr Thr Phe Leu Val Ile Leu Trp Leu Tyr Phe 
1               5                   10                  15      


Tyr Arg Gly Asn Gly Lys Asn Gln Val Glu Gln Ser Pro Gln Ser Leu 
            20                  25                  30          


Ile Ile Leu Glu Gly Lys Asn Cys Thr Leu Gln Cys Asn Tyr Thr Val 
        35                  40                  45              


Ser Pro Phe Ser Asn Leu Arg Trp Tyr Lys Gln Asp Thr Gly Arg Gly 
    50                  55                  60                  


Pro Val Ser Leu Thr Ile Met Thr Phe Ser Glu Asn Thr Lys Ser Asn 
65                  70                  75                  80  


Gly Arg Tyr Thr Ala Thr Leu Asp Ala Asp Thr Lys Gln Ser Ser Leu 
                85                  90                  95      


His Ile Thr Ala Ser Gln Leu Ser Asp Ser Ala Ser Tyr Ile Cys Val 
            100                 105                 110         


Val Ser Ala Arg Asn Ala Gly Asn Met Leu Thr Phe Gly Gly Gly Thr 
        115                 120                 125             


Arg Leu Met Val Lys Pro His Ile Gln Asn Pro Glu Pro Ala Val Tyr 
    130                 135                 140                 


Gln Leu Lys Asp Pro Arg Ser Gln Asp Ser Thr Leu Cys Leu Phe Thr 
145                 150                 155                 160 


Asp Phe Asp Ser Gln Ile Asn Val Pro Lys Thr Met Glu Ser Gly Thr 
                165                 170                 175     


Phe Ile Thr Asp Lys Cys Val Leu Asp Met Lys Ala Met Asp Ser Lys 
            180                 185                 190         


Ser Asn Gly Ala Ile Ala Trp Ser Asn Gln Thr Ser Phe Thr Cys Gln 
        195                 200                 205             


Asp Ile Phe Lys Glu Thr Asn Ala Thr Tyr Pro Ser Ser Asp Val Pro 
    210                 215                 220                 


Cys Asp Ala Thr Leu Thr Glu Lys Ser Phe Glu Thr Asp Met Asn Leu 
225                 230                 235                 240 


Asn Phe Gln Asn Leu Leu Val Met Val Leu Arg Ile Leu Leu Leu Lys 
                245                 250                 255     


Val Ala Gly Phe Asn Leu Leu Met Thr Leu Arg Leu Trp Ser Ser 
            260                 265                 270     


<210> 44
<211> 924
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      polynucleotide

<400> 44
atgggccccc agctccttgg ctatgtggtc ctttgccttc taggagcagg ccccctggaa       60

gcccaagtga cccagaaccc aagatacctc atcacagtga ctggaaagaa gttaacagtg      120

acttgttctc agaatatgaa ccatgagtat atgtcctggt atcgacaaga cccagggctg      180

ggcttaaggc agatctacta ttcaatgaat gttgaggtga ctgataaggg agatgttcct      240

gaagggtaca aagtctctcg aaaagagaag aggaatttcc ccctgatcct ggagtcgccc      300

agccccaacc agacctctct gtacttctgt gcctgcgcta gtagcttcgg caccagcggt      360

cgcggtgaac agtttttcgg gccagggaca cggctcaccg tgctagaaga tcttcgaaac      420

gtaacccctc caaaagtgag tctctttgaa ccgagtaagg ctgagatcgc gaacaaacaa      480

aaggcgaccc tcgtctgtct tgcgcgagga ttttttcccg accacgtgga gttgtcttgg      540

tgggtaaacg gtaaggaagt acacagcggt gtttgcaccg accctcaagc ctacaaggaa      600

tctaactatt catactgcct ttcatcccga cttagggttt ctgctacctt ttggcacaat      660

ccgaggaatc actttaggtg tcaagtacag ttccacggat tgtcagagga ggataaatgg      720

ccggagggct ccccgaagcc ggttacgcag aacattagtg cggaagcctg gggacgagca      780

gactgcggta tcacgtctgc cagctatcag caaggcgttc tgtcagcgac aattctgtac      840

gaaatacttt tgggtaaggc tacattgtat gcggtattgg tgtctacgct ggtagtcatg      900

gccatggtga aacgaaaaaa ctca                                             924


<210> 45
<211> 308
<212> PRT
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      polypeptide

<400> 45
Met Gly Pro Gln Leu Leu Gly Tyr Val Val Leu Cys Leu Leu Gly Ala 
1               5                   10                  15      


Gly Pro Leu Glu Ala Gln Val Thr Gln Asn Pro Arg Tyr Leu Ile Thr 
            20                  25                  30          


Val Thr Gly Lys Lys Leu Thr Val Thr Cys Ser Gln Asn Met Asn His 
        35                  40                  45              


Glu Tyr Met Ser Trp Tyr Arg Gln Asp Pro Gly Leu Gly Leu Arg Gln 
    50                  55                  60                  


Ile Tyr Tyr Ser Met Asn Val Glu Val Thr Asp Lys Gly Asp Val Pro 
65                  70                  75                  80  


Glu Gly Tyr Lys Val Ser Arg Lys Glu Lys Arg Asn Phe Pro Leu Ile 
                85                  90                  95      


Leu Glu Ser Pro Ser Pro Asn Gln Thr Ser Leu Tyr Phe Cys Ala Cys 
            100                 105                 110         


Ala Ser Ser Phe Gly Thr Ser Gly Arg Gly Glu Gln Phe Phe Gly Pro 
        115                 120                 125             


Gly Thr Arg Leu Thr Val Leu Glu Asp Leu Arg Asn Val Thr Pro Pro 
    130                 135                 140                 


Lys Val Ser Leu Phe Glu Pro Ser Lys Ala Glu Ile Ala Asn Lys Gln 
145                 150                 155                 160 


Lys Ala Thr Leu Val Cys Leu Ala Arg Gly Phe Phe Pro Asp His Val 
                165                 170                 175     


Glu Leu Ser Trp Trp Val Asn Gly Lys Glu Val His Ser Gly Val Cys 
            180                 185                 190         


Thr Asp Pro Gln Ala Tyr Lys Glu Ser Asn Tyr Ser Tyr Cys Leu Ser 
        195                 200                 205             


Ser Arg Leu Arg Val Ser Ala Thr Phe Trp His Asn Pro Arg Asn His 
    210                 215                 220                 


Phe Arg Cys Gln Val Gln Phe His Gly Leu Ser Glu Glu Asp Lys Trp 
225                 230                 235                 240 


Pro Glu Gly Ser Pro Lys Pro Val Thr Gln Asn Ile Ser Ala Glu Ala 
                245                 250                 255     


Trp Gly Arg Ala Asp Cys Gly Ile Thr Ser Ala Ser Tyr Gln Gln Gly 
            260                 265                 270         


Val Leu Ser Ala Thr Ile Leu Tyr Glu Ile Leu Leu Gly Lys Ala Thr 
        275                 280                 285             


Leu Tyr Ala Val Leu Val Ser Thr Leu Val Val Met Ala Met Val Lys 
    290                 295                 300                 


Arg Lys Asn Ser 
305             


<210> 46
<211> 1818
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      polynucleotide

<400> 46
atgggccccc agctccttgg ctatgtggtc ctttgccttc taggagcagg ccccctggaa       60

gcccaagtga cccagaaccc aagatacctc atcacagtga ctggaaagaa gttaacagtg      120

acttgttctc agaatatgaa ccatgagtat atgtcctggt atcgacaaga cccagggctg      180

ggcttaaggc agatctacta ttcaatgaat gttgaggtga ctgataaggg agatgttcct      240

gaagggtaca aagtctctcg aaaagagaag aggaatttcc ccctgatcct ggagtcgccc      300

agccccaacc agacctctct gtacttctgt gcctgcgcta gtagcttcgg caccagcggt      360

cgcggtgaac agtttttcgg gccagggaca cggctcaccg tgctagaaga tcttcgaaac      420

gtaacccctc caaaagtgag tctctttgaa ccgagtaagg ctgagatcgc gaacaaacaa      480

aaggcgaccc tcgtctgtct tgcgcgagga ttttttcccg accacgtgga gttgtcttgg      540

tgggtaaacg gtaaggaagt acacagcggt gtttgcaccg accctcaagc ctacaaggaa      600

tctaactatt catactgcct ttcatcccga cttagggttt ctgctacctt ttggcacaat      660

ccgaggaatc actttaggtg tcaagtacag ttccacggat tgtcagagga ggataaatgg      720

ccggagggct ccccgaagcc ggttacgcag aacattagtg cggaagcctg gggacgagca      780

gactgcggta tcacgtctgc cagctatcag caaggcgttc tgtcagcgac aattctgtac      840

gaaatacttt tgggtaaggc tacattgtat gcggtattgg tgtctacgct ggtagtcatg      900

gccatggtga aacgaaaaaa ctcaagagcc aaaagaagcg ggagcggtgc gacaaacttt      960

agcctgttga aacaagccgg cgacgttgaa gagaaccccg gacctatgaa aaagcatctg     1020

acgaccttct tggtgatttt gtggctttat ttttataggg ggaatggcaa aaaccaagtg     1080

gagcagagtc ctcagtccct gatcatcctg gagggaaaga actgcactct tcaatgcaat     1140

tatacagtga gccccttcag caacttaagg tggtataagc aagatacggg gagaggtcct     1200

gtttccctga caatcatgac tttcagtgag aacacaaagt cgaacggaag atatacagca     1260

actctggatg cagacacaaa gcaaagctct ctgcacatca cagcctccca gctcagcgat     1320

tcagcctcct acatctgcgt cgtgtctgcc cgcaacgcag gtaacatgct tacattcgga     1380

gggggaacaa ggttaatggt caaaccccat attcaaaacc cagaacccgc cgtctaccag     1440

ctgaaagacc cgaggtctca agactctacg ttgtgcttgt tcaccgattt cgacagtcag     1500

ataaatgtgc ctaagaccat ggagagtggc actttcatca ctgacaaatg tgtgttggac     1560

atgaaggcta tggacagcaa gtcaaacggc gcgattgctt ggtccaacca aacttctttc     1620

acgtgccagg acatcttcaa ggagacaaac gccacctatc catcctctga tgttccgtgc     1680

gatgcgactc ttaccgagaa aagcttcgag acggacatga acttgaactt ccaaaacctg     1740

cttgtgatgg tactgcgaat acttcttctt aaggtggcgg gcttcaattt gctcatgaca     1800

ctcagacttt ggtctagc                                                   1818


<210> 47
<211> 606
<212> PRT
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      polypeptide

<400> 47
Met Gly Pro Gln Leu Leu Gly Tyr Val Val Leu Cys Leu Leu Gly Ala 
1               5                   10                  15      


Gly Pro Leu Glu Ala Gln Val Thr Gln Asn Pro Arg Tyr Leu Ile Thr 
            20                  25                  30          


Val Thr Gly Lys Lys Leu Thr Val Thr Cys Ser Gln Asn Met Asn His 
        35                  40                  45              


Glu Tyr Met Ser Trp Tyr Arg Gln Asp Pro Gly Leu Gly Leu Arg Gln 
    50                  55                  60                  


Ile Tyr Tyr Ser Met Asn Val Glu Val Thr Asp Lys Gly Asp Val Pro 
65                  70                  75                  80  


Glu Gly Tyr Lys Val Ser Arg Lys Glu Lys Arg Asn Phe Pro Leu Ile 
                85                  90                  95      


Leu Glu Ser Pro Ser Pro Asn Gln Thr Ser Leu Tyr Phe Cys Ala Cys 
            100                 105                 110         


Ala Ser Ser Phe Gly Thr Ser Gly Arg Gly Glu Gln Phe Phe Gly Pro 
        115                 120                 125             


Gly Thr Arg Leu Thr Val Leu Glu Asp Leu Arg Asn Val Thr Pro Pro 
    130                 135                 140                 


Lys Val Ser Leu Phe Glu Pro Ser Lys Ala Glu Ile Ala Asn Lys Gln 
145                 150                 155                 160 


Lys Ala Thr Leu Val Cys Leu Ala Arg Gly Phe Phe Pro Asp His Val 
                165                 170                 175     


Glu Leu Ser Trp Trp Val Asn Gly Lys Glu Val His Ser Gly Val Cys 
            180                 185                 190         


Thr Asp Pro Gln Ala Tyr Lys Glu Ser Asn Tyr Ser Tyr Cys Leu Ser 
        195                 200                 205             


Ser Arg Leu Arg Val Ser Ala Thr Phe Trp His Asn Pro Arg Asn His 
    210                 215                 220                 


Phe Arg Cys Gln Val Gln Phe His Gly Leu Ser Glu Glu Asp Lys Trp 
225                 230                 235                 240 


Pro Glu Gly Ser Pro Lys Pro Val Thr Gln Asn Ile Ser Ala Glu Ala 
                245                 250                 255     


Trp Gly Arg Ala Asp Cys Gly Ile Thr Ser Ala Ser Tyr Gln Gln Gly 
            260                 265                 270         


Val Leu Ser Ala Thr Ile Leu Tyr Glu Ile Leu Leu Gly Lys Ala Thr 
        275                 280                 285             


Leu Tyr Ala Val Leu Val Ser Thr Leu Val Val Met Ala Met Val Lys 
    290                 295                 300                 


Arg Lys Asn Ser Arg Ala Lys Arg Ser Gly Ser Gly Ala Thr Asn Phe 
305                 310                 315                 320 


Ser Leu Leu Lys Gln Ala Gly Asp Val Glu Glu Asn Pro Gly Pro Met 
                325                 330                 335     


Lys Lys His Leu Thr Thr Phe Leu Val Ile Leu Trp Leu Tyr Phe Tyr 
            340                 345                 350         


Arg Gly Asn Gly Lys Asn Gln Val Glu Gln Ser Pro Gln Ser Leu Ile 
        355                 360                 365             


Ile Leu Glu Gly Lys Asn Cys Thr Leu Gln Cys Asn Tyr Thr Val Ser 
    370                 375                 380                 


Pro Phe Ser Asn Leu Arg Trp Tyr Lys Gln Asp Thr Gly Arg Gly Pro 
385                 390                 395                 400 


Val Ser Leu Thr Ile Met Thr Phe Ser Glu Asn Thr Lys Ser Asn Gly 
                405                 410                 415     


Arg Tyr Thr Ala Thr Leu Asp Ala Asp Thr Lys Gln Ser Ser Leu His 
            420                 425                 430         


Ile Thr Ala Ser Gln Leu Ser Asp Ser Ala Ser Tyr Ile Cys Val Val 
        435                 440                 445             


Ser Ala Arg Asn Ala Gly Asn Met Leu Thr Phe Gly Gly Gly Thr Arg 
    450                 455                 460                 


Leu Met Val Lys Pro His Ile Gln Asn Pro Glu Pro Ala Val Tyr Gln 
465                 470                 475                 480 


Leu Lys Asp Pro Arg Ser Gln Asp Ser Thr Leu Cys Leu Phe Thr Asp 
                485                 490                 495     


Phe Asp Ser Gln Ile Asn Val Pro Lys Thr Met Glu Ser Gly Thr Phe 
            500                 505                 510         


Ile Thr Asp Lys Cys Val Leu Asp Met Lys Ala Met Asp Ser Lys Ser 
        515                 520                 525             


Asn Gly Ala Ile Ala Trp Ser Asn Gln Thr Ser Phe Thr Cys Gln Asp 
    530                 535                 540                 


Ile Phe Lys Glu Thr Asn Ala Thr Tyr Pro Ser Ser Asp Val Pro Cys 
545                 550                 555                 560 


Asp Ala Thr Leu Thr Glu Lys Ser Phe Glu Thr Asp Met Asn Leu Asn 
                565                 570                 575     


Phe Gln Asn Leu Leu Val Met Val Leu Arg Ile Leu Leu Leu Lys Val 
            580                 585                 590         


Ala Gly Phe Asn Leu Leu Met Thr Leu Arg Leu Trp Ser Ser 
        595                 600                 605     


<210> 48
<211> 825
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      polynucleotide

<400> 48
atgaaaaagc atctgacgac cttcttggtg attttgtggc tttattttta tagggggaat       60

ggcaaaaacc aagtggagca gagtcctcag tccctgatca tcctggaggg aaagaactgc      120

actcttcaat gcaattatac agtgagcccc ttcagcaact taaggtggta taagcaagat      180

acggggagag gtcctgtttc cctgacaatc atgactttca gtgagaacac aaagtcgaac      240

ggaagatata cagcaactct ggatgcagac acaaagcaaa gctctctgca catcacagcc      300

tcccagctca gcgattcagc ctcctacatc tgcgtcgtgt ctgcccgcaa cgcaggtaac      360

atgcttacat tcggaggggg aacaaggtta atggtcaaac cccatatcca gaaccccgac      420

cccgccgtgt accagctgag ggactccaag tccagcgaca agagcgtgtg tctgtttacg      480

gacttcgaca gccagaccaa cgtgagtcaa agcaaggaca gcgacgtcta cataacggat      540

aagaccgtgc tggacatgcg gagcatggac ttcaagagca acagcgccgt ggcctggtcc      600

aacaagagcg acttcgcctg cgccaacgcc ttcaacaaca gcatcatccc cgaggacacc      660

ttcttcccca gcagcgacgt gccctgcgac gtgaaactgg tggagaagtc cttcgagaca      720

gacaccaatc tgaactttca gaacctgctg gtgatcgtgc tgcggattct gctgctgaaa      780

gtggccggct tcaatctgct gatgaccctg cggctgtgga gcagc                      825


<210> 49
<211> 275
<212> PRT
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      polypeptide

<400> 49
Met Lys Lys His Leu Thr Thr Phe Leu Val Ile Leu Trp Leu Tyr Phe 
1               5                   10                  15      


Tyr Arg Gly Asn Gly Lys Asn Gln Val Glu Gln Ser Pro Gln Ser Leu 
            20                  25                  30          


Ile Ile Leu Glu Gly Lys Asn Cys Thr Leu Gln Cys Asn Tyr Thr Val 
        35                  40                  45              


Ser Pro Phe Ser Asn Leu Arg Trp Tyr Lys Gln Asp Thr Gly Arg Gly 
    50                  55                  60                  


Pro Val Ser Leu Thr Ile Met Thr Phe Ser Glu Asn Thr Lys Ser Asn 
65                  70                  75                  80  


Gly Arg Tyr Thr Ala Thr Leu Asp Ala Asp Thr Lys Gln Ser Ser Leu 
                85                  90                  95      


His Ile Thr Ala Ser Gln Leu Ser Asp Ser Ala Ser Tyr Ile Cys Val 
            100                 105                 110         


Val Ser Ala Arg Asn Ala Gly Asn Met Leu Thr Phe Gly Gly Gly Thr 
        115                 120                 125             


Arg Leu Met Val Lys Pro His Ile Gln Asn Pro Asp Pro Ala Val Tyr 
    130                 135                 140                 


Gln Leu Arg Asp Ser Lys Ser Ser Asp Lys Ser Val Cys Leu Phe Thr 
145                 150                 155                 160 


Asp Phe Asp Ser Gln Thr Asn Val Ser Gln Ser Lys Asp Ser Asp Val 
                165                 170                 175     


Tyr Ile Thr Asp Lys Thr Val Leu Asp Met Arg Ser Met Asp Phe Lys 
            180                 185                 190         


Ser Asn Ser Ala Val Ala Trp Ser Asn Lys Ser Asp Phe Ala Cys Ala 
        195                 200                 205             


Asn Ala Phe Asn Asn Ser Ile Ile Pro Glu Asp Thr Phe Phe Pro Ser 
    210                 215                 220                 


Ser Asp Val Pro Cys Asp Val Lys Leu Val Glu Lys Ser Phe Glu Thr 
225                 230                 235                 240 


Asp Thr Asn Leu Asn Phe Gln Asn Leu Leu Val Ile Val Leu Arg Ile 
                245                 250                 255     


Leu Leu Leu Lys Val Ala Gly Phe Asn Leu Leu Met Thr Leu Arg Leu 
            260                 265                 270         


Trp Ser Ser 
        275 


<210> 50
<211> 936
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      polynucleotide

<400> 50
atgggccccc agctccttgg ctatgtggtc ctttgccttc taggagcagg ccccctggaa       60

gcccaagtga cccagaaccc aagatacctc atcacagtga ctggaaagaa gttaacagtg      120

acttgttctc agaatatgaa ccatgagtat atgtcctggt atcgacaaga cccagggctg      180

ggcttaaggc agatctacta ttcaatgaat gttgaggtga ctgataaggg agatgttcct      240

gaagggtaca aagtctctcg aaaagagaag aggaatttcc ccctgatcct ggagtcgccc      300

agccccaacc agacctctct gtacttctgt gcctgcgcta gtagcttcgg caccagcggt      360

cgcggtgaac agtttttcgg gccagggaca cggctcaccg tgctagaaga tctgaacaag      420

gtgttccctc cagaggtggc cgtgttcgag ccttctaagg ccgagatcgc ccacacacaa      480

aaagccaccc tcgtgtgcct ggccaccggc tttttccccg accacgtgga actgtcttgg      540

tgggtcaacg gcaaagaggt gcactccggc gtgtcaacgg atccccagcc tctgaaagaa      600

cagcctgccc tgaacgacag ccggtactgc ctgagctcca gactgagagt gtccgccacc      660

ttctggcaga acccccggaa ccacttcaga tgccaggtgc agttttacgg cctgagcgag      720

aacgacgagt ggacccagga cagagccaag cccgtgacac aaatcgtgtc tgccgaagcc      780

tggggaagag ccgattgcgg catcaccagc gcctcctatc accagggcgt gctgagcgcc      840

acaatcctgt acgaaatcct gctgggcaag gccaccctgt acgccgtgct ggtgtctgct      900

ctggtgctga tggccatggt caagcggaag gacttt                                936


<210> 51
<211> 312
<212> PRT
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      polypeptide

<400> 51
Met Gly Pro Gln Leu Leu Gly Tyr Val Val Leu Cys Leu Leu Gly Ala 
1               5                   10                  15      


Gly Pro Leu Glu Ala Gln Val Thr Gln Asn Pro Arg Tyr Leu Ile Thr 
            20                  25                  30          


Val Thr Gly Lys Lys Leu Thr Val Thr Cys Ser Gln Asn Met Asn His 
        35                  40                  45              


Glu Tyr Met Ser Trp Tyr Arg Gln Asp Pro Gly Leu Gly Leu Arg Gln 
    50                  55                  60                  


Ile Tyr Tyr Ser Met Asn Val Glu Val Thr Asp Lys Gly Asp Val Pro 
65                  70                  75                  80  


Glu Gly Tyr Lys Val Ser Arg Lys Glu Lys Arg Asn Phe Pro Leu Ile 
                85                  90                  95      


Leu Glu Ser Pro Ser Pro Asn Gln Thr Ser Leu Tyr Phe Cys Ala Cys 
            100                 105                 110         


Ala Ser Ser Phe Gly Thr Ser Gly Arg Gly Glu Gln Phe Phe Gly Pro 
        115                 120                 125             


Gly Thr Arg Leu Thr Val Leu Glu Asp Leu Asn Lys Val Phe Pro Pro 
    130                 135                 140                 


Glu Val Ala Val Phe Glu Pro Ser Lys Ala Glu Ile Ala His Thr Gln 
145                 150                 155                 160 


Lys Ala Thr Leu Val Cys Leu Ala Thr Gly Phe Phe Pro Asp His Val 
                165                 170                 175     


Glu Leu Ser Trp Trp Val Asn Gly Lys Glu Val His Ser Gly Val Ser 
            180                 185                 190         


Thr Asp Pro Gln Pro Leu Lys Glu Gln Pro Ala Leu Asn Asp Ser Arg 
        195                 200                 205             


Tyr Cys Leu Ser Ser Arg Leu Arg Val Ser Ala Thr Phe Trp Gln Asn 
    210                 215                 220                 


Pro Arg Asn His Phe Arg Cys Gln Val Gln Phe Tyr Gly Leu Ser Glu 
225                 230                 235                 240 


Asn Asp Glu Trp Thr Gln Asp Arg Ala Lys Pro Val Thr Gln Ile Val 
                245                 250                 255     


Ser Ala Glu Ala Trp Gly Arg Ala Asp Cys Gly Ile Thr Ser Ala Ser 
            260                 265                 270         


Tyr His Gln Gly Val Leu Ser Ala Thr Ile Leu Tyr Glu Ile Leu Leu 
        275                 280                 285             


Gly Lys Ala Thr Leu Tyr Ala Val Leu Val Ser Ala Leu Val Leu Met 
    290                 295                 300                 


Ala Met Val Lys Arg Lys Asp Phe 
305                 310         


<210> 52
<211> 1851
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      polynucleotide

<400> 52
atgggccccc agctccttgg ctatgtggtc ctttgccttc taggagcagg ccccctggaa       60

gcccaagtga cccagaaccc aagatacctc atcacagtga ctggaaagaa gttaacagtg      120

acttgttctc agaatatgaa ccatgagtat atgtcctggt atcgacaaga cccagggctg      180

ggcttaaggc agatctacta ttcaatgaat gttgaggtga ctgataaggg agatgttcct      240

gaagggtaca aagtctctcg aaaagagaag aggaatttcc ccctgatcct ggagtcgccc      300

agccccaacc agacctctct gtacttctgt gcctgcgcta gtagcttcgg caccagcggt      360

cgcggtgaac agtttttcgg gccagggaca cggctcaccg tgctagaaga tctgaacaag      420

gtgttccctc cagaggtggc cgtgttcgag ccttctaagg ccgagatcgc ccacacacaa      480

aaagccaccc tcgtgtgcct ggccaccggc tttttccccg accacgtgga actgtcttgg      540

tgggtcaacg gcaaagaggt gcactccggc gtgtcaacgg atccccagcc tctgaaagaa      600

cagcctgccc tgaacgacag ccggtactgc ctgagctcca gactgagagt gtccgccacc      660

ttctggcaga acccccggaa ccacttcaga tgccaggtgc agttttacgg cctgagcgag      720

aacgacgagt ggacccagga cagagccaag cccgtgacac aaatcgtgtc tgccgaagcc      780

tggggaagag ccgattgcgg catcaccagc gcctcctatc accagggcgt gctgagcgcc      840

acaatcctgt acgaaatcct gctgggcaag gccaccctgt acgccgtgct ggtgtctgct      900

ctggtgctga tggccatggt caagcggaag gactttggca gcggcagagc caaaagaagc      960

gggagcggtg cgacaaactt tagcctgttg aaacaagccg gcgacgttga agagaacccc     1020

ggacctatga aaaagcatct gacgaccttc ttggtgattt tgtggcttta tttttatagg     1080

gggaatggca aaaaccaagt ggagcagagt cctcagtccc tgatcatcct ggagggaaag     1140

aactgcactc ttcaatgcaa ttatacagtg agccccttca gcaacttaag gtggtataag     1200

caagatacgg ggagaggtcc tgtttccctg acaatcatga ctttcagtga gaacacaaag     1260

tcgaacggaa gatatacagc aactctggat gcagacacaa agcaaagctc tctgcacatc     1320

acagcctccc agctcagcga ttcagcctcc tacatctgcg tcgtgtctgc ccgcaacgca     1380

ggtaacatgc ttacattcgg agggggaaca aggttaatgg tcaaacccca tatccagaac     1440

cccgaccccg ccgtgtacca gctgagggac tccaagtcca gcgacaagag cgtgtgtctg     1500

tttacggact tcgacagcca gaccaacgtg agtcaaagca aggacagcga cgtctacata     1560

acggataaga ccgtgctgga catgcggagc atggacttca agagcaacag cgccgtggcc     1620

tggtccaaca agagcgactt cgcctgcgcc aacgccttca acaacagcat catccccgag     1680

gacaccttct tccccagcag cgacgtgccc tgcgacgtga aactggtgga gaagtccttc     1740

gagacagaca ccaatctgaa ctttcagaac ctgctggtga tcgtgctgcg gattctgctg     1800

ctgaaagtgg ccggcttcaa tctgctgatg accctgcggc tgtggagcag c              1851


<210> 53
<211> 617
<212> PRT
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      polypeptide

<400> 53
Met Gly Pro Gln Leu Leu Gly Tyr Val Val Leu Cys Leu Leu Gly Ala 
1               5                   10                  15      


Gly Pro Leu Glu Ala Gln Val Thr Gln Asn Pro Arg Tyr Leu Ile Thr 
            20                  25                  30          


Val Thr Gly Lys Lys Leu Thr Val Thr Cys Ser Gln Asn Met Asn His 
        35                  40                  45              


Glu Tyr Met Ser Trp Tyr Arg Gln Asp Pro Gly Leu Gly Leu Arg Gln 
    50                  55                  60                  


Ile Tyr Tyr Ser Met Asn Val Glu Val Thr Asp Lys Gly Asp Val Pro 
65                  70                  75                  80  


Glu Gly Tyr Lys Val Ser Arg Lys Glu Lys Arg Asn Phe Pro Leu Ile 
                85                  90                  95      


Leu Glu Ser Pro Ser Pro Asn Gln Thr Ser Leu Tyr Phe Cys Ala Cys 
            100                 105                 110         


Ala Ser Ser Phe Gly Thr Ser Gly Arg Gly Glu Gln Phe Phe Gly Pro 
        115                 120                 125             


Gly Thr Arg Leu Thr Val Leu Glu Asp Leu Asn Lys Val Phe Pro Pro 
    130                 135                 140                 


Glu Val Ala Val Phe Glu Pro Ser Lys Ala Glu Ile Ala His Thr Gln 
145                 150                 155                 160 


Lys Ala Thr Leu Val Cys Leu Ala Thr Gly Phe Phe Pro Asp His Val 
                165                 170                 175     


Glu Leu Ser Trp Trp Val Asn Gly Lys Glu Val His Ser Gly Val Ser 
            180                 185                 190         


Thr Asp Pro Gln Pro Leu Lys Glu Gln Pro Ala Leu Asn Asp Ser Arg 
        195                 200                 205             


Tyr Cys Leu Ser Ser Arg Leu Arg Val Ser Ala Thr Phe Trp Gln Asn 
    210                 215                 220                 


Pro Arg Asn His Phe Arg Cys Gln Val Gln Phe Tyr Gly Leu Ser Glu 
225                 230                 235                 240 


Asn Asp Glu Trp Thr Gln Asp Arg Ala Lys Pro Val Thr Gln Ile Val 
                245                 250                 255     


Ser Ala Glu Ala Trp Gly Arg Ala Asp Cys Gly Ile Thr Ser Ala Ser 
            260                 265                 270         


Tyr His Gln Gly Val Leu Ser Ala Thr Ile Leu Tyr Glu Ile Leu Leu 
        275                 280                 285             


Gly Lys Ala Thr Leu Tyr Ala Val Leu Val Ser Ala Leu Val Leu Met 
    290                 295                 300                 


Ala Met Val Lys Arg Lys Asp Phe Gly Ser Gly Arg Ala Lys Arg Ser 
305                 310                 315                 320 


Gly Ser Gly Ala Thr Asn Phe Ser Leu Leu Lys Gln Ala Gly Asp Val 
                325                 330                 335     


Glu Glu Asn Pro Gly Pro Met Lys Lys His Leu Thr Thr Phe Leu Val 
            340                 345                 350         


Ile Leu Trp Leu Tyr Phe Tyr Arg Gly Asn Gly Lys Asn Gln Val Glu 
        355                 360                 365             


Gln Ser Pro Gln Ser Leu Ile Ile Leu Glu Gly Lys Asn Cys Thr Leu 
    370                 375                 380                 


Gln Cys Asn Tyr Thr Val Ser Pro Phe Ser Asn Leu Arg Trp Tyr Lys 
385                 390                 395                 400 


Gln Asp Thr Gly Arg Gly Pro Val Ser Leu Thr Ile Met Thr Phe Ser 
                405                 410                 415     


Glu Asn Thr Lys Ser Asn Gly Arg Tyr Thr Ala Thr Leu Asp Ala Asp 
            420                 425                 430         


Thr Lys Gln Ser Ser Leu His Ile Thr Ala Ser Gln Leu Ser Asp Ser 
        435                 440                 445             


Ala Ser Tyr Ile Cys Val Val Ser Ala Arg Asn Ala Gly Asn Met Leu 
    450                 455                 460                 


Thr Phe Gly Gly Gly Thr Arg Leu Met Val Lys Pro His Ile Gln Asn 
465                 470                 475                 480 


Pro Asp Pro Ala Val Tyr Gln Leu Arg Asp Ser Lys Ser Ser Asp Lys 
                485                 490                 495     


Ser Val Cys Leu Phe Thr Asp Phe Asp Ser Gln Thr Asn Val Ser Gln 
            500                 505                 510         


Ser Lys Asp Ser Asp Val Tyr Ile Thr Asp Lys Thr Val Leu Asp Met 
        515                 520                 525             


Arg Ser Met Asp Phe Lys Ser Asn Ser Ala Val Ala Trp Ser Asn Lys 
    530                 535                 540                 


Ser Asp Phe Ala Cys Ala Asn Ala Phe Asn Asn Ser Ile Ile Pro Glu 
545                 550                 555                 560 


Asp Thr Phe Phe Pro Ser Ser Asp Val Pro Cys Asp Val Lys Leu Val 
                565                 570                 575     


Glu Lys Ser Phe Glu Thr Asp Thr Asn Leu Asn Phe Gln Asn Leu Leu 
            580                 585                 590         


Val Ile Val Leu Arg Ile Leu Leu Leu Lys Val Ala Gly Phe Asn Leu 
        595                 600                 605             


Leu Met Thr Leu Arg Leu Trp Ser Ser 
    610                 615         


<210> 54
<211> 1122
<212> DNA
<213> Homo sapiens

<400> 54
atgcctcccg ttccaggcgt tccattccgc aacgttgaca acgactcccc gacctcagtt       60

gagttagaag actgggtaga tgcacagcat cccacagatg aggaagagga ggaagcctcc      120

tccgcctctt ccactttgta cttagtattt tccccctctt ctttctccac atcctcttct      180

ctgattcttg gtggtcctga ggaggaggag gtgccctctg gtgtgatacc aaatcttacc      240

gagagcattc ccagtagtcc tccacagggt cctccacagg gtccttccca gagtcctctg      300

agctcctgct gctcctcttt ttcatggagc tcattcagtg aggagtccag cagccagaaa      360

ggggaggata caggcacctg tcagggcctg ccagacagtg agtcctcttt cacatataca      420

ctagatgaaa aggtggccga gttagtggag ttcctgctcc tcaaatacga agcagaggag      480

cctgtaacag aggcagagat gctgatgatt gtcatcaagt acaaagatta ctttcctgtg      540

atactcaaga gagcccgtga gttcatggag cttctttttg gccttgccct gatagaagtg      600

ggccctgacc acttctgtgt gtttgcaaac acagtaggcc tcaccgatga gggtagtgat      660

gatgagggca tgcccgagaa cagcctcctg attattattc tgagtgtgat cttcataaag      720

ggcaactgtg cctctgagga ggtcatctgg gaagtgctga atgcagtagg ggtatatgct      780

gggagggagc acttcgtcta tggggagcct agggagctcc tcactaaagt ttgggtgcag      840

ggacattacc tggagtatcg ggaggtgccc cacagttctc ctccatatta tgaattcctg      900

tggggtccga gagcccattc agaaagcatc aagaagaaag tactagagtt tttagccaag      960

ctgaacaaca ctgttcctag ttcctttcca tcctggtaca aggatgcttt gaaagatgtg     1020

gaagagagag tccaggccac aattgatacc gcagatgatg ccactgtcat ggccagtgaa     1080

agcctcagtg tcatgtccag caacgtctcc ttttctgagt ga                        1122


<210> 55
<211> 373
<212> PRT
<213> Homo sapiens

<400> 55
Met Pro Pro Val Pro Gly Val Pro Phe Arg Asn Val Asp Asn Asp Ser 
1               5                   10                  15      


Pro Thr Ser Val Glu Leu Glu Asp Trp Val Asp Ala Gln His Pro Thr 
            20                  25                  30          


Asp Glu Glu Glu Glu Glu Ala Ser Ser Ala Ser Ser Thr Leu Tyr Leu 
        35                  40                  45              


Val Phe Ser Pro Ser Ser Phe Ser Thr Ser Ser Ser Leu Ile Leu Gly 
    50                  55                  60                  


Gly Pro Glu Glu Glu Glu Val Pro Ser Gly Val Ile Pro Asn Leu Thr 
65                  70                  75                  80  


Glu Ser Ile Pro Ser Ser Pro Pro Gln Gly Pro Pro Gln Gly Pro Ser 
                85                  90                  95      


Gln Ser Pro Leu Ser Ser Cys Cys Ser Ser Phe Ser Trp Ser Ser Phe 
            100                 105                 110         


Ser Glu Glu Ser Ser Ser Gln Lys Gly Glu Asp Thr Gly Thr Cys Gln 
        115                 120                 125             


Gly Leu Pro Asp Ser Glu Ser Ser Phe Thr Tyr Thr Leu Asp Glu Lys 
    130                 135                 140                 


Val Ala Glu Leu Val Glu Phe Leu Leu Leu Lys Tyr Glu Ala Glu Glu 
145                 150                 155                 160 


Pro Val Thr Glu Ala Glu Met Leu Met Ile Val Ile Lys Tyr Lys Asp 
                165                 170                 175     


Tyr Phe Pro Val Ile Leu Lys Arg Ala Arg Glu Phe Met Glu Leu Leu 
            180                 185                 190         


Phe Gly Leu Ala Leu Ile Glu Val Gly Pro Asp His Phe Cys Val Phe 
        195                 200                 205             


Ala Asn Thr Val Gly Leu Thr Asp Glu Gly Ser Asp Asp Glu Gly Met 
    210                 215                 220                 


Pro Glu Asn Ser Leu Leu Ile Ile Ile Leu Ser Val Ile Phe Ile Lys 
225                 230                 235                 240 


Gly Asn Cys Ala Ser Glu Glu Val Ile Trp Glu Val Leu Asn Ala Val 
                245                 250                 255     


Gly Val Tyr Ala Gly Arg Glu His Phe Val Tyr Gly Glu Pro Arg Glu 
            260                 265                 270         


Leu Leu Thr Lys Val Trp Val Gln Gly His Tyr Leu Glu Tyr Arg Glu 
        275                 280                 285             


Val Pro His Ser Ser Pro Pro Tyr Tyr Glu Phe Leu Trp Gly Pro Arg 
    290                 295                 300                 


Ala His Ser Glu Ser Ile Lys Lys Lys Val Leu Glu Phe Leu Ala Lys 
305                 310                 315                 320 


Leu Asn Asn Thr Val Pro Ser Ser Phe Pro Ser Trp Tyr Lys Asp Ala 
                325                 330                 335     


Leu Lys Asp Val Glu Glu Arg Val Gln Ala Thr Ile Asp Thr Ala Asp 
            340                 345                 350         


Asp Ala Thr Val Met Ala Ser Glu Ser Leu Ser Val Met Ser Ser Asn 
        355                 360                 365             


Val Ser Phe Ser Glu 
    370             


<210> 56
<211> 1089
<212> DNA
<213> Homo sapiens

<400> 56
atgctggtca tggcgccccg aaccgtcctc ctgctgctct cggcggccct ggccctgacc       60

gagacctggg ccggctccca ctccatgagg tatttctaca cctccgtgtc ccggcccggc      120

cgcggggagc cccgcttcat ctcagtgggc tacgtggacg acacccagtt cgtgaggttc      180

gacagcgacg ccgcgagtcc gagagaggag ccgcgggcgc cgtggataga gcaggagggg      240

ccggagtatt gggaccggaa cacacagatc tacaaggccc aggcacagac tgaccgagag      300

agcctgcgga acctgcgcgg ctactacaac cagagcgagg ccgggtctca caccctccag      360

agcatgtacg gctgcgacgt ggggccggac gggcgcctcc tccgcgggca tgaccagtac      420

gcctacgacg gcaaggatta catcgccctg aacgaggacc tgcgctcctg gaccgccgcg      480

gacacggcgg ctcagatcac ccagcgcaag tgggaggcgg cccgtgaggc ggagcagcgg      540

agagcctacc tggagggcga gtgcgtggag tggctccgca gatacctgga gaacgggaag      600

gacaagctgg agcgcgctga ccccccaaag acacacgtga cccaccaccc catctctgac      660

catgaggcca ccctgaggtg ctgggccctg ggtttctacc ctgcggagat cacactgacc      720

tggcagcggg atggcgagga ccaaactcag gacactgagc ttgtggagac cagaccagca      780

ggagatagaa ccttccagaa gtgggcagct gtggtggtgc cttctggaga agagcagaga      840

tacacatgcc atgtacagca tgaggggctg ccgaagcccc tcaccctgag atgggagccg      900

tcttcccagt ccaccgtccc catcgtgggc attgttgctg gcctggctgt cctagcagtt      960

gtggtcatcg gagctgtggt cgctgctgtg atgtgtagga ggaagagttc aggtggaaaa     1020

ggagggagct actctcaggc tgcgtgcagc gacagtgccc agggctctga tgtgtctctc     1080

acagcttga                                                             1089


<210> 57
<211> 362
<212> PRT
<213> Homo sapiens

<400> 57
Met Leu Val Met Ala Pro Arg Thr Val Leu Leu Leu Leu Ser Ala Ala 
1               5                   10                  15      


Leu Ala Leu Thr Glu Thr Trp Ala Gly Ser His Ser Met Arg Tyr Phe 
            20                  25                  30          


Tyr Thr Ser Val Ser Arg Pro Gly Arg Gly Glu Pro Arg Phe Ile Ser 
        35                  40                  45              


Val Gly Tyr Val Asp Asp Thr Gln Phe Val Arg Phe Asp Ser Asp Ala 
    50                  55                  60                  


Ala Ser Pro Arg Glu Glu Pro Arg Ala Pro Trp Ile Glu Gln Glu Gly 
65                  70                  75                  80  


Pro Glu Tyr Trp Asp Arg Asn Thr Gln Ile Tyr Lys Ala Gln Ala Gln 
                85                  90                  95      


Thr Asp Arg Glu Ser Leu Arg Asn Leu Arg Gly Tyr Tyr Asn Gln Ser 
            100                 105                 110         


Glu Ala Gly Ser His Thr Leu Gln Ser Met Tyr Gly Cys Asp Val Gly 
        115                 120                 125             


Pro Asp Gly Arg Leu Leu Arg Gly His Asp Gln Tyr Ala Tyr Asp Gly 
    130                 135                 140                 


Lys Asp Tyr Ile Ala Leu Asn Glu Asp Leu Arg Ser Trp Thr Ala Ala 
145                 150                 155                 160 


Asp Thr Ala Ala Gln Ile Thr Gln Arg Lys Trp Glu Ala Ala Arg Glu 
                165                 170                 175     


Ala Glu Gln Arg Arg Ala Tyr Leu Glu Gly Glu Cys Val Glu Trp Leu 
            180                 185                 190         


Arg Arg Tyr Leu Glu Asn Gly Lys Asp Lys Leu Glu Arg Ala Asp Pro 
        195                 200                 205             


Pro Lys Thr His Val Thr His His Pro Ile Ser Asp His Glu Ala Thr 
    210                 215                 220                 


Leu Arg Cys Trp Ala Leu Gly Phe Tyr Pro Ala Glu Ile Thr Leu Thr 
225                 230                 235                 240 


Trp Gln Arg Asp Gly Glu Asp Gln Thr Gln Asp Thr Glu Leu Val Glu 
                245                 250                 255     


Thr Arg Pro Ala Gly Asp Arg Thr Phe Gln Lys Trp Ala Ala Val Val 
            260                 265                 270         


Val Pro Ser Gly Glu Glu Gln Arg Tyr Thr Cys His Val Gln His Glu 
        275                 280                 285             


Gly Leu Pro Lys Pro Leu Thr Leu Arg Trp Glu Pro Ser Ser Gln Ser 
    290                 295                 300                 


Thr Val Pro Ile Val Gly Ile Val Ala Gly Leu Ala Val Leu Ala Val 
305                 310                 315                 320 


Val Val Ile Gly Ala Val Val Ala Ala Val Met Cys Arg Arg Lys Ser 
                325                 330                 335     


Ser Gly Gly Lys Gly Gly Ser Tyr Ser Gln Ala Ala Cys Ser Asp Ser 
            340                 345                 350         


Ala Gln Gly Ser Asp Val Ser Leu Thr Ala 
        355                 360         


<210> 58
<211> 1098
<212> DNA
<213> Homo sapiens

<400> 58
atggccgtca tggcgccccg aaccctcgtc ctgctactct cgggggccct ggccctgacc       60

cagacctggg caggctccca ctccatgagg tatttctcca catccgtgtc ccggcccggc      120

cgcggggagc cccgcttcat cgccgtgggc tacgtggacg acacgcagtt cgtgcggttc      180

gacagcgacg ccgcgagcca gaggatggag ccgcgggcgc cgtggataga gcaggagggg      240

ccggagtatt gggacgagga gacagggaaa gtgaaggccc actcacagac tgaccgagag      300

aacctgcgga tcgcgctccg ctactacaac cagagcgagg ccggttctca caccctccag      360

atgatgtttg gctgcgacgt ggggtcggac gggcgcttcc tccgcgggta ccaccagtac      420

gcctacgacg gcaaggatta catcgccctg aaagaggacc tgcgctcttg gaccgcggcg      480

gacatggcag ctcagatcac caagcgcaag tgggaggcgg cccatgtggc ggagcagcag      540

agagcctacc tggagggcac gtgcgtggac gggctccgca gatacctgga gaacgggaag      600

gagacgctgc agcgcacgga cccccccaag acacatatga cccaccaccc catctctgac      660

catgaggcca ctctgagatg ctgggccctg ggcttctacc ctgcggagat cacactgacc      720

tggcagcggg atggggagga ccagacccag gacacggagc ttgtggagac caggcctgca      780

ggggatggaa ccttccagaa gtgggcagct gtggtggtac cttctggaga ggagcagaga      840

tacacctgcc atgtgcagca tgagggtctg cccaagcccc tcaccctgag atgggagcca      900

tcttcccagc ccaccgtccc catcgtgggc atcattgctg gcctggttct ccttggagct      960

gtgatcactg gagctgtggt cgctgctgtg atgtggagga ggaacagctc agatagaaaa     1020

ggagggagct actctcaggc tgcaagcagt gacagtgccc agggctctga tgtgtctctc     1080

acagcttgta aagtgtga                                                   1098


<210> 59
<211> 365
<212> PRT
<213> Homo sapiens

<400> 59
Met Ala Val Met Ala Pro Arg Thr Leu Val Leu Leu Leu Ser Gly Ala 
1               5                   10                  15      


Leu Ala Leu Thr Gln Thr Trp Ala Gly Ser His Ser Met Arg Tyr Phe 
            20                  25                  30          


Ser Thr Ser Val Ser Arg Pro Gly Arg Gly Glu Pro Arg Phe Ile Ala 
        35                  40                  45              


Val Gly Tyr Val Asp Asp Thr Gln Phe Val Arg Phe Asp Ser Asp Ala 
    50                  55                  60                  


Ala Ser Gln Arg Met Glu Pro Arg Ala Pro Trp Ile Glu Gln Glu Gly 
65                  70                  75                  80  


Pro Glu Tyr Trp Asp Glu Glu Thr Gly Lys Val Lys Ala His Ser Gln 
                85                  90                  95      


Thr Asp Arg Glu Asn Leu Arg Ile Ala Leu Arg Tyr Tyr Asn Gln Ser 
            100                 105                 110         


Glu Ala Gly Ser His Thr Leu Gln Met Met Phe Gly Cys Asp Val Gly 
        115                 120                 125             


Ser Asp Gly Arg Phe Leu Arg Gly Tyr His Gln Tyr Ala Tyr Asp Gly 
    130                 135                 140                 


Lys Asp Tyr Ile Ala Leu Lys Glu Asp Leu Arg Ser Trp Thr Ala Ala 
145                 150                 155                 160 


Asp Met Ala Ala Gln Ile Thr Lys Arg Lys Trp Glu Ala Ala His Val 
                165                 170                 175     


Ala Glu Gln Gln Arg Ala Tyr Leu Glu Gly Thr Cys Val Asp Gly Leu 
            180                 185                 190         


Arg Arg Tyr Leu Glu Asn Gly Lys Glu Thr Leu Gln Arg Thr Asp Pro 
        195                 200                 205             


Pro Lys Thr His Met Thr His His Pro Ile Ser Asp His Glu Ala Thr 
    210                 215                 220                 


Leu Arg Cys Trp Ala Leu Gly Phe Tyr Pro Ala Glu Ile Thr Leu Thr 
225                 230                 235                 240 


Trp Gln Arg Asp Gly Glu Asp Gln Thr Gln Asp Thr Glu Leu Val Glu 
                245                 250                 255     


Thr Arg Pro Ala Gly Asp Gly Thr Phe Gln Lys Trp Ala Ala Val Val 
            260                 265                 270         


Val Pro Ser Gly Glu Glu Gln Arg Tyr Thr Cys His Val Gln His Glu 
        275                 280                 285             


Gly Leu Pro Lys Pro Leu Thr Leu Arg Trp Glu Pro Ser Ser Gln Pro 
    290                 295                 300                 


Thr Val Pro Ile Val Gly Ile Ile Ala Gly Leu Val Leu Leu Gly Ala 
305                 310                 315                 320 


Val Ile Thr Gly Ala Val Val Ala Ala Val Met Trp Arg Arg Asn Ser 
                325                 330                 335     


Ser Asp Arg Lys Gly Gly Ser Tyr Ser Gln Ala Ala Ser Ser Asp Ser 
            340                 345                 350         


Ala Gln Gly Ser Asp Val Ser Leu Thr Ala Cys Lys Val 
        355                 360                 365 


<210> 60
<211> 20
<212> PRT
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      peptide


<220>
<221> SITE
<222> (1)..(10)
<223> This region may encompass 0-10 residues

<220>
<221> SITE
<222> (11)..(20)
<223> This region may encompass 0-10 residues

<400> 60
Gly Gly Gly Gly Gly Gly Gly Gly Gly Gly Ser Ser Ser Ser Ser Ser 
1               5                   10                  15      


Ser Ser Ser Ser 
            20  


<210> 61
<211> 10
<212> PRT
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      peptide

<400> 61
Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser 
1               5                   10  


<210> 62
<211> 8
<212> PRT
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      peptide

<400> 62
Gly Gly Gly Ser Gly Gly Gly Ser 
1               5               


<210> 63
<211> 11
<212> PRT
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      peptide

<400> 63
Gly Gly Gly Ser Gly Gly Gly Ser Gly Gly Ser 
1               5                   10      


<210> 64
<211> 9
<212> PRT
<213> Unknown

<220>
<223> Description of Unknown: 
      "LAGLIDADG" family peptide motif sequence

<400> 64
Leu Ala Gly Leu Ile Asp Ala Asp Gly 
1               5                   


<210> 65
<211> 66
<212> PRT
<213> Homo sapiens

<400> 65
Ser Glu Ser Ser Phe Thr Tyr Thr Leu Asp Glu Lys Val Ala Glu Leu 
1               5                   10                  15      


Val Glu Phe Leu Leu Leu Lys Tyr Glu Ala Glu Glu Pro Val Thr Glu 
            20                  25                  30          


Ala Glu Met Leu Met Ile Val Ile Lys Tyr Lys Asp Tyr Phe Pro Val 
        35                  40                  45              


Ile Leu Lys Arg Ala Arg Glu Phe Met Glu Leu Leu Phe Gly Leu Ala 
    50                  55                  60                  


Leu Ile 
65      


<210> 66
<211> 66
<212> PRT
<213> Homo sapiens

<400> 66
Lys Tyr Glu Ala Glu Glu Pro Val Thr Glu Ala Glu Met Leu Met Ile 
1               5                   10                  15      


Val Ile Lys Tyr Lys Asp Tyr Phe Pro Val Ile Leu Lys Arg Ala Arg 
            20                  25                  30          


Glu Phe Met Glu Leu Leu Phe Gly Leu Ala Leu Ile Glu Val Gly Pro 
        35                  40                  45              


Asp His Phe Cys Val Phe Ala Asn Thr Val Gly Leu Thr Asp Glu Gly 
    50                  55                  60                  


Ser Asp 
65      


<210> 67
<211> 66
<212> PRT
<213> Homo sapiens

<400> 67
Tyr Phe Pro Val Ile Leu Lys Arg Ala Arg Glu Phe Met Glu Leu Leu 
1               5                   10                  15      


Phe Gly Leu Ala Leu Ile Glu Val Gly Pro Asp His Phe Cys Val Phe 
            20                  25                  30          


Ala Asn Thr Val Gly Leu Thr Asp Glu Gly Ser Asp Asp Glu Gly Met 
        35                  40                  45              


Pro Glu Asn Ser Leu Leu Ile Ile Ile Leu Ser Val Ile Phe Ile Lys 
    50                  55                  60                  


Gly Asn 
65      


<210> 68
<211> 66
<212> PRT
<213> Homo sapiens

<400> 68
Glu Val Gly Pro Asp His Phe Cys Val Phe Ala Asn Thr Val Gly Leu 
1               5                   10                  15      


Thr Asp Glu Gly Ser Asp Asp Glu Gly Met Pro Glu Asn Ser Leu Leu 
            20                  25                  30          


Ile Ile Ile Leu Ser Val Ile Phe Ile Lys Gly Asn Cys Ala Ser Glu 
        35                  40                  45              


Glu Val Ile Trp Glu Val Leu Asn Ala Val Gly Val Tyr Ala Gly Arg 
    50                  55                  60                  


Glu His 
65      


<210> 69
<211> 9
<212> PRT
<213> Homo sapiens

<400> 69
Val Gly Leu Thr Asp Glu Gly Ser Asp 
1               5                   


<210> 70
<211> 9
<212> PRT
<213> Homo sapiens

<400> 70
Thr Val Gly Leu Thr Asp Glu Gly Ser 
1               5                   


<210> 71
<211> 9
<212> PRT
<213> Homo sapiens

<400> 71
Asn Thr Val Gly Leu Thr Asp Glu Gly 
1               5                   


<210> 72
<211> 9
<212> PRT
<213> Homo sapiens

<400> 72
Ala Asn Thr Val Gly Leu Thr Asp Glu 
1               5                   


<210> 73
<211> 9
<212> PRT
<213> Homo sapiens

<400> 73
Phe Ala Asn Thr Val Gly Leu Thr Asp 
1               5                   


<210> 74
<211> 9
<212> PRT
<213> Homo sapiens

<400> 74
Val Phe Ala Asn Thr Val Gly Leu Thr 
1               5                   


<210> 75
<211> 9
<212> PRT
<213> Homo sapiens

<400> 75
Cys Val Phe Ala Asn Thr Val Gly Leu 
1               5                   


<210> 76
<211> 9
<212> PRT
<213> Homo sapiens

<400> 76
Phe Cys Val Phe Ala Asn Thr Val Gly 
1               5                   


<210> 77
<211> 9
<212> PRT
<213> Homo sapiens

<400> 77
His Phe Cys Val Phe Ala Asn Thr Val 
1               5                   


<210> 78
<211> 9
<212> PRT
<213> Homo sapiens

<400> 78
Asp His Phe Cys Val Phe Ala Asn Thr 
1               5                   


<210> 79
<211> 9
<212> PRT
<213> Homo sapiens

<400> 79
Pro Asp His Phe Cys Val Phe Ala Asn 
1               5                   


<210> 80
<211> 9
<212> PRT
<213> Homo sapiens

<400> 80
Gly Pro Asp His Phe Cys Val Phe Ala 
1               5                   


<210> 81
<211> 9
<212> PRT
<213> Homo sapiens

<400> 81
Glu Val Gly Pro Asp His Phe Cys Val 
1               5                   


