                         SEQUENCE LISTING

<110>  Research Institute at Nationwide Childrens Hospital
 
<120>  MATERIALS AND METHODS FOR NEUROFIBROMIN 2/MERLIN (NF2) GENE 
       THERAPY

<130>  28335/54446

<150>  US 63/174,803
<151>  2021-04-14

<160>  47    

<170>  PatentIn version 3.5

<210>  1
<211>  1888
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Synthetic


<220>
<221>  misc_feature
<223>  Neurofibromin 2/Merlin polynucleotide  - NF2 Construct

<400>  1
aaagggctca gagtgcaggc cgtggggcgc gagggtcccg ggcctgagcc ccgcgccatg       60

gccggggcca tcgcttcccg catgagcttc agctctctca agaggaagca acccaagacg      120

ttcaccgtga ggatcgtcac catggacgcc gagatggagt tcaattgcga gatgaagtgg      180

aaagggaagg acctctttga tttggtgtgc cggactctgg ggctccgaga aacctggttc      240

tttggactgc agtacacaat caaggacaca gtggcctggc tcaaaatgga caagaaggta      300

ctggatcatg atgtttcaaa ggaagaacca gtcacctttc acttcttggc caaattttat      360

cctgagaatg ctgaagagga gctggttcag gagatcacac aacatttatt cttcttacag      420

gtaaagaagc agattttaga tgaaaagatc tactgccctc ctgaggcttc tgtgctcctg      480

gcttcttacg ccgtccaggc caagtatggt gactacgacc ccagtgttca caagcgggga      540

tttttggccc aagaggaatt gcttccaaaa agggtaataa atctgtatca gatgactccg      600

gaaatgtggg aggagagaat tactgcttgg tacgcagagc accgaggccg agccagggat      660

gaagctgaaa tggaatatct gaagatagct caggacctgg agatgtacgg tgtgaactac      720

tttgcaatcc ggaataaaaa gggcacagag ctgctgcttg gagtggatgc cctggggctt      780

cacatttatg accctgagaa cagactgacc cccaagatct ccttcccgtg gaatgaaatc      840

cgaaacatct cgtacagtga caaggagttt actattaaac cactggataa gaaaattgat      900

gtcttcaagt ttaactcctc aaagcttcgt gttaataagc tgattctcca gctatgtatc      960

gggaaccatg atctatttat gaggagaagg aaagccgatt ctttggaagt tcagcagatg     1020

aaagcccagg ccagggagga gaaggctaga aagcagatgg agcggcagcg cctcgctcga     1080

gagaagcaga tgagggagga ggctgaacgc acgagggatg agttggagag gaggctgctg     1140

cagatgaaag aagaagcaac aatggccaac gaagcactga tgcggtctga ggagacagct     1200

gacctgttgg ctgaaaaggc ccagatcacc gaggaggagg caaaacttct ggcccagaag     1260

gccgcagagg ctgagcagga aatgcagcgc atcaaggcca cagcgattcg cacggaggag     1320

gagaagcgcc tgatggagca gaaggtgctg gaagccgagg tgctggcact gaagatggct     1380

gaggagtcag agaggagggc caaagaggca gatcagctga agcaggacct gcaggaagca     1440

cgcgaggcgg agcgaagagc caagcagaag ctcctggaga ttgccaccaa gcccacgtac     1500

ccgcccatga acccaattcc agcaccgttg cctcctgaca taccaagctt caacctcatt     1560

ggtgacagcc tgtctttcga cttcaaagat actgacatga agcggctttc catggagata     1620

gagaaagaaa aagtggaata catggaaaag agcaagcatc tgcaggagca gctcaatgaa     1680

ctcaagacag aaatcgaggc cttgaaactg aaagagaggg agacagctct ggatattctg     1740

cacaatgaga actccgacag gggtggcagc agcaagcaca ataccattaa aaagctcacc     1800

ttgcagagcg ccaagtcccg agtggccttc tttgaagagc tctagcaggt gacccagcca     1860

ccccaggacc tgccacttct cctgctac                                        1888


<210>  2
<211>  2301
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Synthetic


<220>
<221>  misc_feature
<223>  NF2-2.3kb promoter

<400>  2
cccggtgtca cgtattttta tcagcagcca tttgttgtcc ctgtggggag cccagaaaac       60

ccagcccggt tctcccacct gcggggaaga aatgaagcaa tgataatgaa gacactccca      120

tgccaagccc atactgccct gagcaatcag ttttggtggg gagaatttgc tagcagaagg      180

caggacataa agtccccaca gcagcctcac tgggtgtggc agcaaatcat tcctgaggcc      240

tggccggtgc taccaggcac agcaggggtc cgtgcagaag aactagattt attccattaa      300

tataccgtta cagcaacaat gtctgctgag tactccggaa ctgtaattca catttcctga      360

ggctgtagta gggagaattt ggaagcaggg cagcacagtg ctaaccagca ggctctgggt      420

gggacagacc tgggtttgag tcctagcttt gcctttcact atctgcatta tagtcagcga      480

gtggctctat catatctctc agtatcttca cctgtggagt tgggggggtg atgctaatgt      540

tagctaacat ttatggggtg attattgttg ttaaaactca gtacaccggg cgcggtggct      600

cacgcctgta atcccagcac tttgggaggc caaggtgggc agatcacctg aggtcagaag      660

tttgagacca gcctggctaa catggtgaaa ccccgtccct actaaaaata caaaaattag      720

ccgggcgtgg tggcgggtgc ctgtaatccc aactactggg gaggctgagg caggagaatt      780

gcttgaaccc gggaggcgga ggttgcagag agccgagacc gccccattgt actccagcct      840

gggcaacaag agcgaaactc tgtctcaaaa caaaaaacaa acgaaaaaac acagtaaatt      900

gtccctattt gactactaag agctatttta aaatagaatt tattatctaa gtacagaaag      960

gtgtaattat cccccctaca cccgttagaa cccttgatga cactaaataa ataatacatg     1020

aatacggttc aaaaatgggc atcatagagt ataaaataaa gaatgctttc attttcaacc     1080

caaattcagc aatttcatag gatgccaggc tcagctctaa agccttatat gtattcagtg     1140

cgctgaaatt caacaacctc acgaggtagg tataaccaat aataattcta ggcggggcgt     1200

ggtggctcac gcctgtaatc ctagcacttc gggaggccga ggcgggcgga tcacctgagg     1260

ttcgagacca gcctgacgaa catggagaaa ccccgtctct aataaaaata caaaattagc     1320

cgggcgtggt gacgcatacc tgtaatccca gctactcggg aggctgacgc cggaaaatcg     1380

cttgaacccg ggaggcggag gttgcagtga gccgagatcg cgccactgca ctccagcctg     1440

ggcaacaaga gcgaaactcc gtcccaataa taataataat taataataat aataataaca     1500

ataataataa taattctaaa gggaagcaga gggatctggc gggaaagtgc cagcaaacct     1560

aacaggcctc cacaagtgtc tttaaagttt cataggggtc ggtatatgtg attaactgcc     1620

aaagaagaat attcgccgtg tgtccgaaac gcagtcccct ggggcgccac actcggagcc     1680

tacttgaacc gaagagtccc tccctgggcc aacgaaggac ccaattcccc tcgccccgga     1740

tccagcctct aagtggtttc ccgggtaagg tcagcagagg tccgccgcct caaccagtct     1800

tgttagagta ggcacaaaag cattcagagt gactgccact gtagccactc aacgccgagc     1860

ctaggcctgc tttttttgca gttagagtga aactttccat tggtggagtc accccaaagg     1920

aggcgggacg gagcgggaaa gtcctgccta ccttggcctt cccagccaat cgcagcatct     1980

atgcgtcagc ctccggttcg gttgcgctgc gcgtagtggt ctgggcgacc tgagggcggg     2040

gccgggagca ggccccgggc tgtggggagg gtgcgcttcc cgcgggcgcg cggagtgagg     2100

acggtgacag ccacgcgcgc gcgtacgcgc ccgatgcagc gcggccccgt gaccctagtc     2160

ggccgctgag aggcgcgcgg agtctgggcc gctgccgtct aggggtcccg tcccgaggcg     2220

tccccggcat ctccggcccg aatcccggag tgccgggtcg cgcctgcacc gaaggtcccg     2280

gctcctgtgc cctccctgca g                                               2301


<210>  3
<211>  400
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Synthetic


<220>
<221>  misc_feature
<223>  NF2-400bp promoter

<400>  3
aagagtccct ccctgggcca acgaaggacc caattcccct cgccccggat ccagcctcta       60

agtggtttcc cgggtaaggt cagcagaggt ccgccgcctc aaccagtctt gttagagtag      120

gcacaaaagc attcagagtg actgccactg tagccactca acgccgagcc taggcctgct      180

ttttttgcag ttagagtgaa actttccatt ggtggagtca ccccaaagga ggcgggacgg      240

agcgggaaag tcctgcctac cttggccttc ccagccaatc gcagcatcta tgcgtcagcc      300

tccggttcgg ttgcgctgcg cgtagtggtc tgggcgacct gagggcgggg ccgggagcag      360

gccccgggct gtggggaggg tgcgcttccc gcgggcgcgc                            400


<210>  4
<211>  610
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Synthetic


<220>
<221>  misc_feature
<223>  NF2-610bp promoter

<400>  4
aagagtccct ccctgggcca acgaaggacc caattcccct cgccccggat ccagcctcta       60

agtggtttcc cgggtaaggt cagcagaggt ccgccgcctc aaccagtctt gttagagtag      120

gcacaaaagc attcagagtg actgccactg tagccactca acgccgagcc taggcctgct      180

ttttttgcag ttagagtgaa actttccatt ggtggagtca ccccaaagga ggcgggacgg      240

agcgggaaag tcctgcctac cttggccttc ccagccaatc gcagcatcta tgcgtcagcc      300

tccggttcgg ttgcgctgcg cgtagtggtc tgggcgacct gagggcgggg ccgggagcag      360

gccccgggct gtggggaggg tgcgcttccc gcgggcgcgc ggagtgagga cggtgacagc      420

cacgcgcgcg cgtacgcgcc cgatgcagcg cggccccgtg accctagtcg gccgctgaga      480

ggcgcgcgga gtctgggccg ctgccgtcta ggggtcccgt cccgaggcgt ccccggcatc      540

tccggcccga atcccggagt gccgggtcgc gcctgcaccg aaggtcccgg ctcctgtgcc      600

ctccctgcag                                                             610


<210>  5
<211>  2091
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Synthetic


<220>
<221>  misc_feature
<223>  NF2-2.1kb promoter

<400>  5
cccggtgtca cgtattttta tcagcagcca tttgttgtcc ctgtggggag cccagaaaac       60

ccagcccggt tctcccacct gcggggaaga aatgaagcaa tgataatgaa gacactccca      120

tgccaagccc atactgccct gagcaatcag ttttggtggg gagaatttgc tagcagaagg      180

caggacataa agtccccaca gcagcctcac tgggtgtggc agcaaatcat tcctgaggcc      240

tggccggtgc taccaggcac agcaggggtc cgtgcagaag aactagattt attccattaa      300

tataccgtta cagcaacaat gtctgctgag tactccggaa ctgtaattca catttcctga      360

ggctgtagta gggagaattt ggaagcaggg cagcacagtg ctaaccagca ggctctgggt      420

gggacagacc tgggtttgag tcctagcttt gcctttcact atctgcatta tagtcagcga      480

gtggctctat catatctctc agtatcttca cctgtggagt tgggggggtg atgctaatgt      540

tagctaacat ttatggggtg attattgttg ttaaaactca gtacaccggg cgcggtggct      600

cacgcctgta atcccagcac tttgggaggc caaggtgggc agatcacctg aggtcagaag      660

tttgagacca gcctggctaa catggtgaaa ccccgtccct actaaaaata caaaaattag      720

ccgggcgtgg tggcgggtgc ctgtaatccc aactactggg gaggctgagg caggagaatt      780

gcttgaaccc gggaggcgga ggttgcagag agccgagacc gccccattgt actccagcct      840

gggcaacaag agcgaaactc tgtctcaaaa caaaaaacaa acgaaaaaac acagtaaatt      900

gtccctattt gactactaag agctatttta aaatagaatt tattatctaa gtacagaaag      960

gtgtaattat cccccctaca cccgttagaa cccttgatga cactaaataa ataatacatg     1020

aatacggttc aaaaatgggc atcatagagt ataaaataaa gaatgctttc attttcaacc     1080

caaattcagc aatttcatag gatgccaggc tcagctctaa agccttatat gtattcagtg     1140

cgctgaaatt caacaacctc acgaggtagg tataaccaat aataattcta ggcggggcgt     1200

ggtggctcac gcctgtaatc ctagcacttc gggaggccga ggcgggcgga tcacctgagg     1260

ttcgagacca gcctgacgaa catggagaaa ccccgtctct aataaaaata caaaattagc     1320

cgggcgtggt gacgcatacc tgtaatccca gctactcggg aggctgacgc cggaaaatcg     1380

cttgaacccg ggaggcggag gttgcagtga gccgagatcg cgccactgca ctccagcctg     1440

ggcaacaaga gcgaaactcc gtcccaataa taataataat taataataat aataataaca     1500

ataataataa taattctaaa gggaagcaga gggatctggc gggaaagtgc cagcaaacct     1560

aacaggcctc cacaagtgtc tttaaagttt cataggggtc ggtatatgtg attaactgcc     1620

aaagaagaat attcgccgtg tgtccgaaac gcagtcccct ggggcgccac actcggagcc     1680

tacttgaacc gaagagtccc tccctgggcc aacgaaggac ccaattcccc tcgccccgga     1740

tccagcctct aagtggtttc ccgggtaagg tcagcagagg tccgccgcct caaccagtct     1800

tgttagagta ggcacaaaag cattcagagt gactgccact gtagccactc aacgccgagc     1860

ctaggcctgc tttttttgca gttagagtga aactttccat tggtggagtc accccaaagg     1920

aggcgggacg gagcgggaaa gtcctgccta ccttggcctt cccagccaat cgcagcatct     1980

atgcgtcagc ctccggttcg gttgcgctgc gcgtagtggt ctgggcgacc tgagggcggg     2040

gccgggagca ggccccgggc tgtggggagg gtgcgcttcc cgcgggcgcg c              2091


<210>  6
<211>  2483
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Synthetic


<220>
<221>  misc_feature
<223>  NF2-400bp- NF2 Expression cassette

<220>
<221>  misc_feature
<222>  (1)..(400)
<223>  NF2 400bp Promoter

<220>
<221>  misc_feature
<222>  (413)..(512)
<223>  SV40 Intron

<220>
<221>  misc_feature
<222>  (530)..(2417)
<223>  NF2

<220>
<221>  misc_feature
<222>  (2435)..(2483)
<223>  Poly A

<400>  6
aagagtccct ccctgggcca acgaaggacc caattcccct cgccccggat ccagcctcta       60

agtggtttcc cgggtaaggt cagcagaggt ccgccgcctc aaccagtctt gttagagtag      120

gcacaaaagc attcagagtg actgccactg tagccactca acgccgagcc taggcctgct      180

ttttttgcag ttagagtgaa actttccatt ggtggagtca ccccaaagga ggcgggacgg      240

agcgggaaag tcctgcctac cttggccttc ccagccaatc gcagcatcta tgcgtcagcc      300

tccggttcgg ttgcgctgcg cgtagtggtc tgggcgacct gagggcgggg ccgggagcag      360

gccccgggct gtggggaggg tgcgcttccc gcgggcgcgc ctgcagataa ctggtaagtt      420

tagtcttttt tgtcttttat ttcaggtccc ggatccggtg gtggtgcaaa tcaaagaact      480

gctcctcagt cgatgttgcc tttacttcta ggcctgtacg gaaaccggta aagggctcag      540

agtgcaggcc gtggggcgcg agggtcccgg gcctgagccc cgcgccatgg ccggggccat      600

cgcttcccgc atgagcttca gctctctcaa gaggaagcaa cccaagacgt tcaccgtgag      660

gatcgtcacc atggacgccg agatggagtt caattgcgag atgaagtgga aagggaagga      720

cctctttgat ttggtgtgcc ggactctggg gctccgagaa acctggttct ttggactgca      780

gtacacaatc aaggacacag tggcctggct caaaatggac aagaaggtac tggatcatga      840

tgtttcaaag gaagaaccag tcacctttca cttcttggcc aaattttatc ctgagaatgc      900

tgaagaggag ctggttcagg agatcacaca acatttattc ttcttacagg taaagaagca      960

gattttagat gaaaagatct actgccctcc tgaggcttct gtgctcctgg cttcttacgc     1020

cgtccaggcc aagtatggtg actacgaccc cagtgttcac aagcggggat ttttggccca     1080

agaggaattg cttccaaaaa gggtaataaa tctgtatcag atgactccgg aaatgtggga     1140

ggagagaatt actgcttggt acgcagagca ccgaggccga gccagggatg aagctgaaat     1200

ggaatatctg aagatagctc aggacctgga gatgtacggt gtgaactact ttgcaatccg     1260

gaataaaaag ggcacagagc tgctgcttgg agtggatgcc ctggggcttc acatttatga     1320

ccctgagaac agactgaccc ccaagatctc cttcccgtgg aatgaaatcc gaaacatctc     1380

gtacagtgac aaggagttta ctattaaacc actggataag aaaattgatg tcttcaagtt     1440

taactcctca aagcttcgtg ttaataagct gattctccag ctatgtatcg ggaaccatga     1500

tctatttatg aggagaagga aagccgattc tttggaagtt cagcagatga aagcccaggc     1560

cagggaggag aaggctagaa agcagatgga gcggcagcgc ctcgctcgag agaagcagat     1620

gagggaggag gctgaacgca cgagggatga gttggagagg aggctgctgc agatgaaaga     1680

agaagcaaca atggccaacg aagcactgat gcggtctgag gagacagctg acctgttggc     1740

tgaaaaggcc cagatcaccg aggaggaggc aaaacttctg gcccagaagg ccgcagaggc     1800

tgagcaggaa atgcagcgca tcaaggccac agcgattcgc acggaggagg agaagcgcct     1860

gatggagcag aaggtgctgg aagccgaggt gctggcactg aagatggctg aggagtcaga     1920

gaggagggcc aaagaggcag atcagctgaa gcaggacctg caggaagcac gcgaggcgga     1980

gcgaagagcc aagcagaagc tcctggagat tgccaccaag cccacgtacc cgcccatgaa     2040

cccaattcca gcaccgttgc ctcctgacat accaagcttc aacctcattg gtgacagcct     2100

gtctttcgac ttcaaagata ctgacatgaa gcggctttcc atggagatag agaaagaaaa     2160

agtggaatac atggaaaaga gcaagcatct gcaggagcag ctcaatgaac tcaagacaga     2220

aatcgaggcc ttgaaactga aagagaggga gacagctctg gatattctgc acaatgagaa     2280

ctccgacagg ggtggcagca gcaagcacaa taccattaaa aagctcacct tgcagagcgc     2340

caagtcccga gtggccttct ttgaagagct ctagcaggtg acccagccac cccaggacct     2400

gccacttctc ctgctactgt acaagtaaaa gcttaataaa agatctttat tttcattaga     2460

tctgtgtgtt ggttttttgt gtg                                             2483


<210>  7
<211>  2687
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Synthetic


<220>
<221>  misc_feature
<223>  NF2-610bp- NF2 Expression cassette

<220>
<221>  misc_feature
<222>  (1)..(610)
<223>  NF2 610bp Promoter

<220>
<221>  misc_feature
<222>  (617)..(716)
<223>  SV40 Intron

<220>
<221>  misc_feature
<222>  (734)..(2621)
<223>  NF2

<220>
<221>  misc_feature
<222>  (2639)..(2687)
<223>  Poly A

<400>  7
aagagtccct ccctgggcca acgaaggacc caattcccct cgccccggat ccagcctcta       60

agtggtttcc cgggtaaggt cagcagaggt ccgccgcctc aaccagtctt gttagagtag      120

gcacaaaagc attcagagtg actgccactg tagccactca acgccgagcc taggcctgct      180

ttttttgcag ttagagtgaa actttccatt ggtggagtca ccccaaagga ggcgggacgg      240

agcgggaaag tcctgcctac cttggccttc ccagccaatc gcagcatcta tgcgtcagcc      300

tccggttcgg ttgcgctgcg cgtagtggtc tgggcgacct gagggcgggg ccgggagcag      360

gccccgggct gtggggaggg tgcgcttccc gcgggcgcgc ggagtgagga cggtgacagc      420

cacgcgcgcg cgtacgcgcc cgatgcagcg cggccccgtg accctagtcg gccgctgaga      480

ggcgcgcgga gtctgggccg ctgccgtcta ggggtcccgt cccgaggcgt ccccggcatc      540

tccggcccga atcccggagt gccgggtcgc gcctgcaccg aaggtcccgg ctcctgtgcc      600

ctccctgcag ataactggta agtttagtct tttttgtctt ttatttcagg tcccggatcc      660

ggtggtggtg caaatcaaag aactgctcct cagtcgatgt tgcctttact tctaggcctg      720

tacggaaacc ggtaaagggc tcagagtgca ggccgtgggg cgcgagggtc ccgggcctga      780

gccccgcgcc atggccgggg ccatcgcttc ccgcatgagc ttcagctctc tcaagaggaa      840

gcaacccaag acgttcaccg tgaggatcgt caccatggac gccgagatgg agttcaattg      900

cgagatgaag tggaaaggga aggacctctt tgatttggtg tgccggactc tggggctccg      960

agaaacctgg ttctttggac tgcagtacac aatcaaggac acagtggcct ggctcaaaat     1020

ggacaagaag gtactggatc atgatgtttc aaaggaagaa ccagtcacct ttcacttctt     1080

ggccaaattt tatcctgaga atgctgaaga ggagctggtt caggagatca cacaacattt     1140

attcttctta caggtaaaga agcagatttt agatgaaaag atctactgcc ctcctgaggc     1200

ttctgtgctc ctggcttctt acgccgtcca ggccaagtat ggtgactacg accccagtgt     1260

tcacaagcgg ggatttttgg cccaagagga attgcttcca aaaagggtaa taaatctgta     1320

tcagatgact ccggaaatgt gggaggagag aattactgct tggtacgcag agcaccgagg     1380

ccgagccagg gatgaagctg aaatggaata tctgaagata gctcaggacc tggagatgta     1440

cggtgtgaac tactttgcaa tccggaataa aaagggcaca gagctgctgc ttggagtgga     1500

tgccctgggg cttcacattt atgaccctga gaacagactg acccccaaga tctccttccc     1560

gtggaatgaa atccgaaaca tctcgtacag tgacaaggag tttactatta aaccactgga     1620

taagaaaatt gatgtcttca agtttaactc ctcaaagctt cgtgttaata agctgattct     1680

ccagctatgt atcgggaacc atgatctatt tatgaggaga aggaaagccg attctttgga     1740

agttcagcag atgaaagccc aggccaggga ggagaaggct agaaagcaga tggagcggca     1800

gcgcctcgct cgagagaagc agatgaggga ggaggctgaa cgcacgaggg atgagttgga     1860

gaggaggctg ctgcagatga aagaagaagc aacaatggcc aacgaagcac tgatgcggtc     1920

tgaggagaca gctgacctgt tggctgaaaa ggcccagatc accgaggagg aggcaaaact     1980

tctggcccag aaggccgcag aggctgagca ggaaatgcag cgcatcaagg ccacagcgat     2040

tcgcacggag gaggagaagc gcctgatgga gcagaaggtg ctggaagccg aggtgctggc     2100

actgaagatg gctgaggagt cagagaggag ggccaaagag gcagatcagc tgaagcagga     2160

cctgcaggaa gcacgcgagg cggagcgaag agccaagcag aagctcctgg agattgccac     2220

caagcccacg tacccgccca tgaacccaat tccagcaccg ttgcctcctg acataccaag     2280

cttcaacctc attggtgaca gcctgtcttt cgacttcaaa gatactgaca tgaagcggct     2340

ttccatggag atagagaaag aaaaagtgga atacatggaa aagagcaagc atctgcagga     2400

gcagctcaat gaactcaaga cagaaatcga ggccttgaaa ctgaaagaga gggagacagc     2460

tctggatatt ctgcacaatg agaactccga caggggtggc agcagcaagc acaataccat     2520

taaaaagctc accttgcaga gcgccaagtc ccgagtggcc ttctttgaag agctctagca     2580

ggtgacccag ccaccccagg acctgccact tctcctgcta ctgtacaagt aaaagcttaa     2640

taaaagatct ttattttcat tagatctgtg tgttggtttt ttgtgtg                   2687


<210>  8
<211>  4174
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Synthetic


<220>
<221>  misc_feature
<223>  NF2-2.1kb- NF2 Expression cassette

<220>
<221>  misc_feature
<222>  (1)..(2091)
<223>  NF2 2.1kb Promoter

<220>
<221>  misc_feature
<222>  (2104)..(2203)
<223>  SV40 Intron

<220>
<221>  misc_feature
<222>  (2221)..(4108)
<223>  NF2

<220>
<221>  misc_feature
<222>  (4126)..(4174)
<223>  Poly A

<400>  8
cccggtgtca cgtattttta tcagcagcca tttgttgtcc ctgtggggag cccagaaaac       60

ccagcccggt tctcccacct gcggggaaga aatgaagcaa tgataatgaa gacactccca      120

tgccaagccc atactgccct gagcaatcag ttttggtggg gagaatttgc tagcagaagg      180

caggacataa agtccccaca gcagcctcac tgggtgtggc agcaaatcat tcctgaggcc      240

tggccggtgc taccaggcac agcaggggtc cgtgcagaag aactagattt attccattaa      300

tataccgtta cagcaacaat gtctgctgag tactccggaa ctgtaattca catttcctga      360

ggctgtagta gggagaattt ggaagcaggg cagcacagtg ctaaccagca ggctctgggt      420

gggacagacc tgggtttgag tcctagcttt gcctttcact atctgcatta tagtcagcga      480

gtggctctat catatctctc agtatcttca cctgtggagt tgggggggtg atgctaatgt      540

tagctaacat ttatggggtg attattgttg ttaaaactca gtacaccggg cgcggtggct      600

cacgcctgta atcccagcac tttgggaggc caaggtgggc agatcacctg aggtcagaag      660

tttgagacca gcctggctaa catggtgaaa ccccgtccct actaaaaata caaaaattag      720

ccgggcgtgg tggcgggtgc ctgtaatccc aactactggg gaggctgagg caggagaatt      780

gcttgaaccc gggaggcgga ggttgcagag agccgagacc gccccattgt actccagcct      840

gggcaacaag agcgaaactc tgtctcaaaa caaaaaacaa acgaaaaaac acagtaaatt      900

gtccctattt gactactaag agctatttta aaatagaatt tattatctaa gtacagaaag      960

gtgtaattat cccccctaca cccgttagaa cccttgatga cactaaataa ataatacatg     1020

aatacggttc aaaaatgggc atcatagagt ataaaataaa gaatgctttc attttcaacc     1080

caaattcagc aatttcatag gatgccaggc tcagctctaa agccttatat gtattcagtg     1140

cgctgaaatt caacaacctc acgaggtagg tataaccaat aataattcta ggcggggcgt     1200

ggtggctcac gcctgtaatc ctagcacttc gggaggccga ggcgggcgga tcacctgagg     1260

ttcgagacca gcctgacgaa catggagaaa ccccgtctct aataaaaata caaaattagc     1320

cgggcgtggt gacgcatacc tgtaatccca gctactcggg aggctgacgc cggaaaatcg     1380

cttgaacccg ggaggcggag gttgcagtga gccgagatcg cgccactgca ctccagcctg     1440

ggcaacaaga gcgaaactcc gtcccaataa taataataat taataataat aataataaca     1500

ataataataa taattctaaa gggaagcaga gggatctggc gggaaagtgc cagcaaacct     1560

aacaggcctc cacaagtgtc tttaaagttt cataggggtc ggtatatgtg attaactgcc     1620

aaagaagaat attcgccgtg tgtccgaaac gcagtcccct ggggcgccac actcggagcc     1680

tacttgaacc gaagagtccc tccctgggcc aacgaaggac ccaattcccc tcgccccgga     1740

tccagcctct aagtggtttc ccgggtaagg tcagcagagg tccgccgcct caaccagtct     1800

tgttagagta ggcacaaaag cattcagagt gactgccact gtagccactc aacgccgagc     1860

ctaggcctgc tttttttgca gttagagtga aactttccat tggtggagtc accccaaagg     1920

aggcgggacg gagcgggaaa gtcctgccta ccttggcctt cccagccaat cgcagcatct     1980

atgcgtcagc ctccggttcg gttgcgctgc gcgtagtggt ctgggcgacc tgagggcggg     2040

gccgggagca ggccccgggc tgtggggagg gtgcgcttcc cgcgggcgcg cctgcagata     2100

actggtaagt ttagtctttt ttgtctttta tttcaggtcc cggatccggt ggtggtgcaa     2160

atcaaagaac tgctcctcag tcgatgttgc ctttacttct aggcctgtac ggaaaccggt     2220

aaagggctca gagtgcaggc cgtggggcgc gagggtcccg ggcctgagcc ccgcgccatg     2280

gccggggcca tcgcttcccg catgagcttc agctctctca agaggaagca acccaagacg     2340

ttcaccgtga ggatcgtcac catggacgcc gagatggagt tcaattgcga gatgaagtgg     2400

aaagggaagg acctctttga tttggtgtgc cggactctgg ggctccgaga aacctggttc     2460

tttggactgc agtacacaat caaggacaca gtggcctggc tcaaaatgga caagaaggta     2520

ctggatcatg atgtttcaaa ggaagaacca gtcacctttc acttcttggc caaattttat     2580

cctgagaatg ctgaagagga gctggttcag gagatcacac aacatttatt cttcttacag     2640

gtaaagaagc agattttaga tgaaaagatc tactgccctc ctgaggcttc tgtgctcctg     2700

gcttcttacg ccgtccaggc caagtatggt gactacgacc ccagtgttca caagcgggga     2760

tttttggccc aagaggaatt gcttccaaaa agggtaataa atctgtatca gatgactccg     2820

gaaatgtggg aggagagaat tactgcttgg tacgcagagc accgaggccg agccagggat     2880

gaagctgaaa tggaatatct gaagatagct caggacctgg agatgtacgg tgtgaactac     2940

tttgcaatcc ggaataaaaa gggcacagag ctgctgcttg gagtggatgc cctggggctt     3000

cacatttatg accctgagaa cagactgacc cccaagatct ccttcccgtg gaatgaaatc     3060

cgaaacatct cgtacagtga caaggagttt actattaaac cactggataa gaaaattgat     3120

gtcttcaagt ttaactcctc aaagcttcgt gttaataagc tgattctcca gctatgtatc     3180

gggaaccatg atctatttat gaggagaagg aaagccgatt ctttggaagt tcagcagatg     3240

aaagcccagg ccagggagga gaaggctaga aagcagatgg agcggcagcg cctcgctcga     3300

gagaagcaga tgagggagga ggctgaacgc acgagggatg agttggagag gaggctgctg     3360

cagatgaaag aagaagcaac aatggccaac gaagcactga tgcggtctga ggagacagct     3420

gacctgttgg ctgaaaaggc ccagatcacc gaggaggagg caaaacttct ggcccagaag     3480

gccgcagagg ctgagcagga aatgcagcgc atcaaggcca cagcgattcg cacggaggag     3540

gagaagcgcc tgatggagca gaaggtgctg gaagccgagg tgctggcact gaagatggct     3600

gaggagtcag agaggagggc caaagaggca gatcagctga agcaggacct gcaggaagca     3660

cgcgaggcgg agcgaagagc caagcagaag ctcctggaga ttgccaccaa gcccacgtac     3720

ccgcccatga acccaattcc agcaccgttg cctcctgaca taccaagctt caacctcatt     3780

ggtgacagcc tgtctttcga cttcaaagat actgacatga agcggctttc catggagata     3840

gagaaagaaa aagtggaata catggaaaag agcaagcatc tgcaggagca gctcaatgaa     3900

ctcaagacag aaatcgaggc cttgaaactg aaagagaggg agacagctct ggatattctg     3960

cacaatgaga actccgacag gggtggcagc agcaagcaca ataccattaa aaagctcacc     4020

ttgcagagcg ccaagtcccg agtggccttc tttgaagagc tctagcaggt gacccagcca     4080

ccccaggacc tgccacttct cctgctactg tacaagtaaa agcttaataa aagatcttta     4140

ttttcattag atctgtgtgt tggttttttg tgtg                                 4174


<210>  9
<211>  4378
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Synthetic


<220>
<221>  misc_feature
<223>  NF2-2.3kb-NF2 Expression cassette

<220>
<221>  misc_feature
<222>  (1)..(2295)
<223>  NF2 2.3kb Promoter

<220>
<221>  misc_feature
<222>  (2308)..(2407)
<223>  SV40 Intron

<220>
<221>  misc_feature
<222>  (2425)..(4312)
<223>  NF2

<220>
<221>  misc_feature
<222>  (4330)..(4378)
<223>  Poly A

<400>  9
cccggtgtca cgtattttta tcagcagcca tttgttgtcc ctgtggggag cccagaaaac       60

ccagcccggt tctcccacct gcggggaaga aatgaagcaa tgataatgaa gacactccca      120

tgccaagccc atactgccct gagcaatcag ttttggtggg gagaatttgc tagcagaagg      180

caggacataa agtccccaca gcagcctcac tgggtgtggc agcaaatcat tcctgaggcc      240

tggccggtgc taccaggcac agcaggggtc cgtgcagaag aactagattt attccattaa      300

tataccgtta cagcaacaat gtctgctgag tactccggaa ctgtaattca catttcctga      360

ggctgtagta gggagaattt ggaagcaggg cagcacagtg ctaaccagca ggctctgggt      420

gggacagacc tgggtttgag tcctagcttt gcctttcact atctgcatta tagtcagcga      480

gtggctctat catatctctc agtatcttca cctgtggagt tgggggggtg atgctaatgt      540

tagctaacat ttatggggtg attattgttg ttaaaactca gtacaccggg cgcggtggct      600

cacgcctgta atcccagcac tttgggaggc caaggtgggc agatcacctg aggtcagaag      660

tttgagacca gcctggctaa catggtgaaa ccccgtccct actaaaaata caaaaattag      720

ccgggcgtgg tggcgggtgc ctgtaatccc aactactggg gaggctgagg caggagaatt      780

gcttgaaccc gggaggcgga ggttgcagag agccgagacc gccccattgt actccagcct      840

gggcaacaag agcgaaactc tgtctcaaaa caaaaaacaa acgaaaaaac acagtaaatt      900

gtccctattt gactactaag agctatttta aaatagaatt tattatctaa gtacagaaag      960

gtgtaattat cccccctaca cccgttagaa cccttgatga cactaaataa ataatacatg     1020

aatacggttc aaaaatgggc atcatagagt ataaaataaa gaatgctttc attttcaacc     1080

caaattcagc aatttcatag gatgccaggc tcagctctaa agccttatat gtattcagtg     1140

cgctgaaatt caacaacctc acgaggtagg tataaccaat aataattcta ggcggggcgt     1200

ggtggctcac gcctgtaatc ctagcacttc gggaggccga ggcgggcgga tcacctgagg     1260

ttcgagacca gcctgacgaa catggagaaa ccccgtctct aataaaaata caaaattagc     1320

cgggcgtggt gacgcatacc tgtaatccca gctactcggg aggctgacgc cggaaaatcg     1380

cttgaacccg ggaggcggag gttgcagtga gccgagatcg cgccactgca ctccagcctg     1440

ggcaacaaga gcgaaactcc gtcccaataa taataataat taataataat aataataaca     1500

ataataataa taattctaaa gggaagcaga gggatctggc gggaaagtgc cagcaaacct     1560

aacaggcctc cacaagtgtc tttaaagttt cataggggtc ggtatatgtg attaactgcc     1620

aaagaagaat attcgccgtg tgtccgaaac gcagtcccct ggggcgccac actcggagcc     1680

tacttgaacc gaagagtccc tccctgggcc aacgaaggac ccaattcccc tcgccccgga     1740

tccagcctct aagtggtttc ccgggtaagg tcagcagagg tccgccgcct caaccagtct     1800

tgttagagta ggcacaaaag cattcagagt gactgccact gtagccactc aacgccgagc     1860

ctaggcctgc tttttttgca gttagagtga aactttccat tggtggagtc accccaaagg     1920

aggcgggacg gagcgggaaa gtcctgccta ccttggcctt cccagccaat cgcagcatct     1980

atgcgtcagc ctccggttcg gttgcgctgc gcgtagtggt ctgggcgacc tgagggcggg     2040

gccgggagca ggccccgggc tgtggggagg gtgcgcttcc cgcgggcgcg cggagtgagg     2100

acggtgacag ccacgcgcgc gcgtacgcgc ccgatgcagc gcggccccgt gaccctagtc     2160

ggccgctgag aggcgcgcgg agtctgggcc gctgccgtct aggggtcccg tcccgaggcg     2220

tccccggcat ctccggcccg aatcccggag tgccgggtcg cgcctgcacc gaaggtcccg     2280

gctcctgtgc cctccctgca gataactggt aagtttagtc ttttttgtct tttatttcag     2340

gtcccggatc cggtggtggt gcaaatcaaa gaactgctcc tcagtcgatg ttgcctttac     2400

ttctaggcct gtacggaaac cggtaaaggg ctcagagtgc aggccgtggg gcgcgagggt     2460

cccgggcctg agccccgcgc catggccggg gccatcgctt cccgcatgag cttcagctct     2520

ctcaagagga agcaacccaa gacgttcacc gtgaggatcg tcaccatgga cgccgagatg     2580

gagttcaatt gcgagatgaa gtggaaaggg aaggacctct ttgatttggt gtgccggact     2640

ctggggctcc gagaaacctg gttctttgga ctgcagtaca caatcaagga cacagtggcc     2700

tggctcaaaa tggacaagaa ggtactggat catgatgttt caaaggaaga accagtcacc     2760

tttcacttct tggccaaatt ttatcctgag aatgctgaag aggagctggt tcaggagatc     2820

acacaacatt tattcttctt acaggtaaag aagcagattt tagatgaaaa gatctactgc     2880

cctcctgagg cttctgtgct cctggcttct tacgccgtcc aggccaagta tggtgactac     2940

gaccccagtg ttcacaagcg gggatttttg gcccaagagg aattgcttcc aaaaagggta     3000

ataaatctgt atcagatgac tccggaaatg tgggaggaga gaattactgc ttggtacgca     3060

gagcaccgag gccgagccag ggatgaagct gaaatggaat atctgaagat agctcaggac     3120

ctggagatgt acggtgtgaa ctactttgca atccggaata aaaagggcac agagctgctg     3180

cttggagtgg atgccctggg gcttcacatt tatgaccctg agaacagact gacccccaag     3240

atctccttcc cgtggaatga aatccgaaac atctcgtaca gtgacaagga gtttactatt     3300

aaaccactgg ataagaaaat tgatgtcttc aagtttaact cctcaaagct tcgtgttaat     3360

aagctgattc tccagctatg tatcgggaac catgatctat ttatgaggag aaggaaagcc     3420

gattctttgg aagttcagca gatgaaagcc caggccaggg aggagaaggc tagaaagcag     3480

atggagcggc agcgcctcgc tcgagagaag cagatgaggg aggaggctga acgcacgagg     3540

gatgagttgg agaggaggct gctgcagatg aaagaagaag caacaatggc caacgaagca     3600

ctgatgcggt ctgaggagac agctgacctg ttggctgaaa aggcccagat caccgaggag     3660

gaggcaaaac ttctggccca gaaggccgca gaggctgagc aggaaatgca gcgcatcaag     3720

gccacagcga ttcgcacgga ggaggagaag cgcctgatgg agcagaaggt gctggaagcc     3780

gaggtgctgg cactgaagat ggctgaggag tcagagagga gggccaaaga ggcagatcag     3840

ctgaagcagg acctgcagga agcacgcgag gcggagcgaa gagccaagca gaagctcctg     3900

gagattgcca ccaagcccac gtacccgccc atgaacccaa ttccagcacc gttgcctcct     3960

gacataccaa gcttcaacct cattggtgac agcctgtctt tcgacttcaa agatactgac     4020

atgaagcggc tttccatgga gatagagaaa gaaaaagtgg aatacatgga aaagagcaag     4080

catctgcagg agcagctcaa tgaactcaag acagaaatcg aggccttgaa actgaaagag     4140

agggagacag ctctggatat tctgcacaat gagaactccg acaggggtgg cagcagcaag     4200

cacaatacca ttaaaaagct caccttgcag agcgccaagt cccgagtggc cttctttgaa     4260

gagctctagc aggtgaccca gccaccccag gacctgccac ttctcctgct actgtacaag     4320

taaaagctta ataaaagatc tttattttca ttagatctgt gtgttggttt tttgtgtg       4378


<210>  10
<211>  1312
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Synthetic


<220>
<221>  misc_feature
<223>  NF2-400bp- GFP Expression cassette

<220>
<221>  misc_feature
<222>  (1)..(400)
<223>  NF2 400bp Promoter

<220>
<221>  misc_feature
<222>  (413)..(512)
<223>  SV40 Intron

<220>
<221>  misc_feature
<222>  (538)..(1257)
<223>  GFP

<220>
<221>  misc_feature
<222>  (1264)..(1312)
<223>  Poly A

<400>  10
aagagtccct ccctgggcca acgaaggacc caattcccct cgccccggat ccagcctcta       60

agtggtttcc cgggtaaggt cagcagaggt ccgccgcctc aaccagtctt gttagagtag      120

gcacaaaagc attcagagtg actgccactg tagccactca acgccgagcc taggcctgct      180

ttttttgcag ttagagtgaa actttccatt ggtggagtca ccccaaagga ggcgggacgg      240

agcgggaaag tcctgcctac cttggccttc ccagccaatc gcagcatcta tgcgtcagcc      300

tccggttcgg ttgcgctgcg cgtagtggtc tgggcgacct gagggcgggg ccgggagcag      360

gccccgggct gtggggaggg tgcgcttccc gcgggcgcgc ctgcagataa ctggtaagtt      420

tagtcttttt tgtcttttat ttcaggtccc ggatccggtg gtggtgcaaa tcaaagaact      480

gctcctcagt cgatgttgcc tttacttcta ggcctgtacg gaaaccggtg tgttactatg      540

gtgagcaagg gcgaggagct gttcaccggg gtggtgccca tcctggtcga gctggacggc      600

gacgtaaacg gccacaagtt cagcgtgtcc ggcgagggcg agggcgatgc cacctacggc      660

aagctgaccc tgaagttcat ctgcaccacc ggcaagctgc ccgtgccctg gcccaccctc      720

gtgaccaccc tgacctacgg cgtgcagtgc ttcagccgct accccgacca catgaagcag      780

cacgacttct tcaagtccgc catgcccgaa ggctacgtcc aggagcgcac catcttcttc      840

aaggacgacg gcaactacaa gacccgcgcc gaggtgaagt tcgagggcga caccctggtg      900

aaccgcatcg agctgaaggg catcgacttc aaggaggacg gcaacatcct ggggcacaag      960

ctggagtaca actacaacag ccacaacgtc tatatcatgg ccgacaagca gaagaacggc     1020

atcaaggtga acttcaagat ccgccacaac atcgaggacg gcagcgtgca gctcgccgac     1080

cactaccagc agaacacccc catcggcgac ggccccgtgc tgctgcccga caaccactac     1140

ctgagcaccc agtccgccct gagcaaagac cccaacgaga agcgcgatca catggtcctg     1200

ctggagttcg tgaccgccgc cgggatcact ctcggcatgg acgagctgta caagtaaaag     1260

cttaataaaa gatctttatt ttcattagat ctgtgtgttg gttttttgtg tg             1312


<210>  11
<211>  1516
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Synthetic


<220>
<221>  misc_feature
<223>  NF2-610bp- GFP Expression cassette

<220>
<221>  misc_feature
<222>  (1)..(610)
<223>  NF2 610bp Promoter

<220>
<221>  misc_feature
<222>  (617)..(716)
<223>  SV40 Intron

<220>
<221>  misc_feature
<222>  (742)..(1461)
<223>  GFP

<220>
<221>  misc_feature
<222>  (1468)..(1516)
<223>  Poly A

<400>  11
aagagtccct ccctgggcca acgaaggacc caattcccct cgccccggat ccagcctcta       60

agtggtttcc cgggtaaggt cagcagaggt ccgccgcctc aaccagtctt gttagagtag      120

gcacaaaagc attcagagtg actgccactg tagccactca acgccgagcc taggcctgct      180

ttttttgcag ttagagtgaa actttccatt ggtggagtca ccccaaagga ggcgggacgg      240

agcgggaaag tcctgcctac cttggccttc ccagccaatc gcagcatcta tgcgtcagcc      300

tccggttcgg ttgcgctgcg cgtagtggtc tgggcgacct gagggcgggg ccgggagcag      360

gccccgggct gtggggaggg tgcgcttccc gcgggcgcgc ggagtgagga cggtgacagc      420

cacgcgcgcg cgtacgcgcc cgatgcagcg cggccccgtg accctagtcg gccgctgaga      480

ggcgcgcgga gtctgggccg ctgccgtcta ggggtcccgt cccgaggcgt ccccggcatc      540

tccggcccga atcccggagt gccgggtcgc gcctgcaccg aaggtcccgg ctcctgtgcc      600

ctccctgcag ataactggta agtttagtct tttttgtctt ttatttcagg tcccggatcc      660

ggtggtggtg caaatcaaag aactgctcct cagtcgatgt tgcctttact tctaggcctg      720

tacggaaacc ggtgtgttac tatggtgagc aagggcgagg agctgttcac cggggtggtg      780

cccatcctgg tcgagctgga cggcgacgta aacggccaca agttcagcgt gtccggcgag      840

ggcgagggcg atgccaccta cggcaagctg accctgaagt tcatctgcac caccggcaag      900

ctgcccgtgc cctggcccac cctcgtgacc accctgacct acggcgtgca gtgcttcagc      960

cgctaccccg accacatgaa gcagcacgac ttcttcaagt ccgccatgcc cgaaggctac     1020

gtccaggagc gcaccatctt cttcaaggac gacggcaact acaagacccg cgccgaggtg     1080

aagttcgagg gcgacaccct ggtgaaccgc atcgagctga agggcatcga cttcaaggag     1140

gacggcaaca tcctggggca caagctggag tacaactaca acagccacaa cgtctatatc     1200

atggccgaca agcagaagaa cggcatcaag gtgaacttca agatccgcca caacatcgag     1260

gacggcagcg tgcagctcgc cgaccactac cagcagaaca cccccatcgg cgacggcccc     1320

gtgctgctgc ccgacaacca ctacctgagc acccagtccg ccctgagcaa agaccccaac     1380

gagaagcgcg atcacatggt cctgctggag ttcgtgaccg ccgccgggat cactctcggc     1440

atggacgagc tgtacaagta aaagcttaat aaaagatctt tattttcatt agatctgtgt     1500

gttggttttt tgtgtg                                                     1516


<210>  12
<211>  3003
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Synthetic


<220>
<221>  misc_feature
<223>  NF2-2.1kb- GFP Expression cassette

<220>
<221>  misc_feature
<222>  (1)..(2091)
<223>  NF2 2.1kb Promoter

<220>
<221>  misc_feature
<222>  (2104)..(2203)
<223>  SV40 Intron

<220>
<221>  misc_feature
<222>  (2229)..(2948)
<223>  GFP

<220>
<221>  misc_feature
<222>  (2955)..(3003)
<223>  Poly A

<400>  12
cccggtgtca cgtattttta tcagcagcca tttgttgtcc ctgtggggag cccagaaaac       60

ccagcccggt tctcccacct gcggggaaga aatgaagcaa tgataatgaa gacactccca      120

tgccaagccc atactgccct gagcaatcag ttttggtggg gagaatttgc tagcagaagg      180

caggacataa agtccccaca gcagcctcac tgggtgtggc agcaaatcat tcctgaggcc      240

tggccggtgc taccaggcac agcaggggtc cgtgcagaag aactagattt attccattaa      300

tataccgtta cagcaacaat gtctgctgag tactccggaa ctgtaattca catttcctga      360

ggctgtagta gggagaattt ggaagcaggg cagcacagtg ctaaccagca ggctctgggt      420

gggacagacc tgggtttgag tcctagcttt gcctttcact atctgcatta tagtcagcga      480

gtggctctat catatctctc agtatcttca cctgtggagt tgggggggtg atgctaatgt      540

tagctaacat ttatggggtg attattgttg ttaaaactca gtacaccggg cgcggtggct      600

cacgcctgta atcccagcac tttgggaggc caaggtgggc agatcacctg aggtcagaag      660

tttgagacca gcctggctaa catggtgaaa ccccgtccct actaaaaata caaaaattag      720

ccgggcgtgg tggcgggtgc ctgtaatccc aactactggg gaggctgagg caggagaatt      780

gcttgaaccc gggaggcgga ggttgcagag agccgagacc gccccattgt actccagcct      840

gggcaacaag agcgaaactc tgtctcaaaa caaaaaacaa acgaaaaaac acagtaaatt      900

gtccctattt gactactaag agctatttta aaatagaatt tattatctaa gtacagaaag      960

gtgtaattat cccccctaca cccgttagaa cccttgatga cactaaataa ataatacatg     1020

aatacggttc aaaaatgggc atcatagagt ataaaataaa gaatgctttc attttcaacc     1080

caaattcagc aatttcatag gatgccaggc tcagctctaa agccttatat gtattcagtg     1140

cgctgaaatt caacaacctc acgaggtagg tataaccaat aataattcta ggcggggcgt     1200

ggtggctcac gcctgtaatc ctagcacttc gggaggccga ggcgggcgga tcacctgagg     1260

ttcgagacca gcctgacgaa catggagaaa ccccgtctct aataaaaata caaaattagc     1320

cgggcgtggt gacgcatacc tgtaatccca gctactcggg aggctgacgc cggaaaatcg     1380

cttgaacccg ggaggcggag gttgcagtga gccgagatcg cgccactgca ctccagcctg     1440

ggcaacaaga gcgaaactcc gtcccaataa taataataat taataataat aataataaca     1500

ataataataa taattctaaa gggaagcaga gggatctggc gggaaagtgc cagcaaacct     1560

aacaggcctc cacaagtgtc tttaaagttt cataggggtc ggtatatgtg attaactgcc     1620

aaagaagaat attcgccgtg tgtccgaaac gcagtcccct ggggcgccac actcggagcc     1680

tacttgaacc gaagagtccc tccctgggcc aacgaaggac ccaattcccc tcgccccgga     1740

tccagcctct aagtggtttc ccgggtaagg tcagcagagg tccgccgcct caaccagtct     1800

tgttagagta ggcacaaaag cattcagagt gactgccact gtagccactc aacgccgagc     1860

ctaggcctgc tttttttgca gttagagtga aactttccat tggtggagtc accccaaagg     1920

aggcgggacg gagcgggaaa gtcctgccta ccttggcctt cccagccaat cgcagcatct     1980

atgcgtcagc ctccggttcg gttgcgctgc gcgtagtggt ctgggcgacc tgagggcggg     2040

gccgggagca ggccccgggc tgtggggagg gtgcgcttcc cgcgggcgcg cctgcagata     2100

actggtaagt ttagtctttt ttgtctttta tttcaggtcc cggatccggt ggtggtgcaa     2160

atcaaagaac tgctcctcag tcgatgttgc ctttacttct aggcctgtac ggaaaccggt     2220

gtgttactat ggtgagcaag ggcgaggagc tgttcaccgg ggtggtgccc atcctggtcg     2280

agctggacgg cgacgtaaac ggccacaagt tcagcgtgtc cggcgagggc gagggcgatg     2340

ccacctacgg caagctgacc ctgaagttca tctgcaccac cggcaagctg cccgtgccct     2400

ggcccaccct cgtgaccacc ctgacctacg gcgtgcagtg cttcagccgc taccccgacc     2460

acatgaagca gcacgacttc ttcaagtccg ccatgcccga aggctacgtc caggagcgca     2520

ccatcttctt caaggacgac ggcaactaca agacccgcgc cgaggtgaag ttcgagggcg     2580

acaccctggt gaaccgcatc gagctgaagg gcatcgactt caaggaggac ggcaacatcc     2640

tggggcacaa gctggagtac aactacaaca gccacaacgt ctatatcatg gccgacaagc     2700

agaagaacgg catcaaggtg aacttcaaga tccgccacaa catcgaggac ggcagcgtgc     2760

agctcgccga ccactaccag cagaacaccc ccatcggcga cggccccgtg ctgctgcccg     2820

acaaccacta cctgagcacc cagtccgccc tgagcaaaga ccccaacgag aagcgcgatc     2880

acatggtcct gctggagttc gtgaccgccg ccgggatcac tctcggcatg gacgagctgt     2940

acaagtaaaa gcttaataaa agatctttat tttcattaga tctgtgtgtt ggttttttgt     3000

gtg                                                                   3003


<210>  13
<211>  3207
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Synthetic


<220>
<221>  misc_feature
<223>  NF2-2.3kb-GFP Expression cassette

<220>
<221>  misc_feature
<222>  (1)..(2301)
<223>  NF2 2.3kb Promoter

<220>
<221>  misc_feature
<222>  (2308)..(2407)
<223>  SV40 Intron

<220>
<221>  misc_feature
<222>  (2433)..(3152)
<223>  GFP

<220>
<221>  misc_feature
<222>  (3159)..(3207)
<223>  GFP CDS

<400>  13
cccggtgtca cgtattttta tcagcagcca tttgttgtcc ctgtggggag cccagaaaac       60

ccagcccggt tctcccacct gcggggaaga aatgaagcaa tgataatgaa gacactccca      120

tgccaagccc atactgccct gagcaatcag ttttggtggg gagaatttgc tagcagaagg      180

caggacataa agtccccaca gcagcctcac tgggtgtggc agcaaatcat tcctgaggcc      240

tggccggtgc taccaggcac agcaggggtc cgtgcagaag aactagattt attccattaa      300

tataccgtta cagcaacaat gtctgctgag tactccggaa ctgtaattca catttcctga      360

ggctgtagta gggagaattt ggaagcaggg cagcacagtg ctaaccagca ggctctgggt      420

gggacagacc tgggtttgag tcctagcttt gcctttcact atctgcatta tagtcagcga      480

gtggctctat catatctctc agtatcttca cctgtggagt tgggggggtg atgctaatgt      540

tagctaacat ttatggggtg attattgttg ttaaaactca gtacaccggg cgcggtggct      600

cacgcctgta atcccagcac tttgggaggc caaggtgggc agatcacctg aggtcagaag      660

tttgagacca gcctggctaa catggtgaaa ccccgtccct actaaaaata caaaaattag      720

ccgggcgtgg tggcgggtgc ctgtaatccc aactactggg gaggctgagg caggagaatt      780

gcttgaaccc gggaggcgga ggttgcagag agccgagacc gccccattgt actccagcct      840

gggcaacaag agcgaaactc tgtctcaaaa caaaaaacaa acgaaaaaac acagtaaatt      900

gtccctattt gactactaag agctatttta aaatagaatt tattatctaa gtacagaaag      960

gtgtaattat cccccctaca cccgttagaa cccttgatga cactaaataa ataatacatg     1020

aatacggttc aaaaatgggc atcatagagt ataaaataaa gaatgctttc attttcaacc     1080

caaattcagc aatttcatag gatgccaggc tcagctctaa agccttatat gtattcagtg     1140

cgctgaaatt caacaacctc acgaggtagg tataaccaat aataattcta ggcggggcgt     1200

ggtggctcac gcctgtaatc ctagcacttc gggaggccga ggcgggcgga tcacctgagg     1260

ttcgagacca gcctgacgaa catggagaaa ccccgtctct aataaaaata caaaattagc     1320

cgggcgtggt gacgcatacc tgtaatccca gctactcggg aggctgacgc cggaaaatcg     1380

cttgaacccg ggaggcggag gttgcagtga gccgagatcg cgccactgca ctccagcctg     1440

ggcaacaaga gcgaaactcc gtcccaataa taataataat taataataat aataataaca     1500

ataataataa taattctaaa gggaagcaga gggatctggc gggaaagtgc cagcaaacct     1560

aacaggcctc cacaagtgtc tttaaagttt cataggggtc ggtatatgtg attaactgcc     1620

aaagaagaat attcgccgtg tgtccgaaac gcagtcccct ggggcgccac actcggagcc     1680

tacttgaacc gaagagtccc tccctgggcc aacgaaggac ccaattcccc tcgccccgga     1740

tccagcctct aagtggtttc ccgggtaagg tcagcagagg tccgccgcct caaccagtct     1800

tgttagagta ggcacaaaag cattcagagt gactgccact gtagccactc aacgccgagc     1860

ctaggcctgc tttttttgca gttagagtga aactttccat tggtggagtc accccaaagg     1920

aggcgggacg gagcgggaaa gtcctgccta ccttggcctt cccagccaat cgcagcatct     1980

atgcgtcagc ctccggttcg gttgcgctgc gcgtagtggt ctgggcgacc tgagggcggg     2040

gccgggagca ggccccgggc tgtggggagg gtgcgcttcc cgcgggcgcg cggagtgagg     2100

acggtgacag ccacgcgcgc gcgtacgcgc ccgatgcagc gcggccccgt gaccctagtc     2160

ggccgctgag aggcgcgcgg agtctgggcc gctgccgtct aggggtcccg tcccgaggcg     2220

tccccggcat ctccggcccg aatcccggag tgccgggtcg cgcctgcacc gaaggtcccg     2280

gctcctgtgc cctccctgca gataactggt aagtttagtc ttttttgtct tttatttcag     2340

gtcccggatc cggtggtggt gcaaatcaaa gaactgctcc tcagtcgatg ttgcctttac     2400

ttctaggcct gtacggaaac cggtgtgtta ctatggtgag caagggcgag gagctgttca     2460

ccggggtggt gcccatcctg gtcgagctgg acggcgacgt aaacggccac aagttcagcg     2520

tgtccggcga gggcgagggc gatgccacct acggcaagct gaccctgaag ttcatctgca     2580

ccaccggcaa gctgcccgtg ccctggccca ccctcgtgac caccctgacc tacggcgtgc     2640

agtgcttcag ccgctacccc gaccacatga agcagcacga cttcttcaag tccgccatgc     2700

ccgaaggcta cgtccaggag cgcaccatct tcttcaagga cgacggcaac tacaagaccc     2760

gcgccgaggt gaagttcgag ggcgacaccc tggtgaaccg catcgagctg aagggcatcg     2820

acttcaagga ggacggcaac atcctggggc acaagctgga gtacaactac aacagccaca     2880

acgtctatat catggccgac aagcagaaga acggcatcaa ggtgaacttc aagatccgcc     2940

acaacatcga ggacggcagc gtgcagctcg ccgaccacta ccagcagaac acccccatcg     3000

gcgacggccc cgtgctgctg cccgacaacc actacctgag cacccagtcc gccctgagca     3060

aagaccccaa cgagaagcgc gatcacatgg tcctgctgga gttcgtgacc gccgccggga     3120

tcactctcgg catggacgag ctgtacaagt aaaagcttaa taaaagatct ttattttcat     3180

tagatctgtg tgttggtttt ttgtgtg                                         3207


<210>  14
<211>  720
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Synethetic


<220>
<221>  misc_feature
<223>  GFP

<400>  14
atggtgagca agggcgagga gctgttcacc ggggtggtgc ccatcctggt cgagctggac       60

ggcgacgtaa acggccacaa gttcagcgtg tccggcgagg gcgagggcga tgccacctac      120

ggcaagctga ccctgaagtt catctgcacc accggcaagc tgcccgtgcc ctggcccacc      180

ctcgtgacca ccctgaccta cggcgtgcag tgcttcagcc gctaccccga ccacatgaag      240

cagcacgact tcttcaagtc cgccatgccc gaaggctacg tccaggagcg caccatcttc      300

ttcaaggacg acggcaacta caagacccgc gccgaggtga agttcgaggg cgacaccctg      360

gtgaaccgca tcgagctgaa gggcatcgac ttcaaggagg acggcaacat cctggggcac      420

aagctggagt acaactacaa cagccacaac gtctatatca tggccgacaa gcagaagaac      480

ggcatcaagg tgaacttcaa gatccgccac aacatcgagg acggcagcgt gcagctcgcc      540

gaccactacc agcagaacac ccccatcggc gacggccccg tgctgctgcc cgacaaccac      600

tacctgagca cccagtccgc cctgagcaaa gaccccaacg agaagcgcga tcacatggtc      660

ctgctggagt tcgtgaccgc cgccgggatc actctcggca tggacgagct gtacaagtaa      720


<210>  15
<211>  595
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic


<220>
<221>  MISC_FEATURE
<223>  Merlin protein

<400>  15

Met Ala Gly Ala Ile Ala Ser Arg Met Ser Phe Ser Ser Leu Lys Arg 
1               5                   10                  15      


Lys Gln Pro Lys Thr Phe Thr Val Arg Ile Val Thr Met Asp Ala Glu 
            20                  25                  30          


Met Glu Phe Asn Cys Glu Met Lys Trp Lys Gly Lys Asp Leu Phe Asp 
        35                  40                  45              


Leu Val Cys Arg Thr Leu Gly Leu Arg Glu Thr Trp Phe Phe Gly Leu 
    50                  55                  60                  


Gln Tyr Thr Ile Lys Asp Thr Val Ala Trp Leu Lys Met Asp Lys Lys 
65                  70                  75                  80  


Val Leu Asp His Asp Val Ser Lys Glu Glu Pro Val Thr Phe His Phe 
                85                  90                  95      


Leu Ala Lys Phe Tyr Pro Glu Asn Ala Glu Glu Glu Leu Val Gln Glu 
            100                 105                 110         


Ile Thr Gln His Leu Phe Phe Leu Gln Val Lys Lys Gln Ile Leu Asp 
        115                 120                 125             


Glu Lys Ile Tyr Cys Pro Pro Glu Ala Ser Val Leu Leu Ala Ser Tyr 
    130                 135                 140                 


Ala Val Gln Ala Lys Tyr Gly Asp Tyr Asp Pro Ser Val His Lys Arg 
145                 150                 155                 160 


Gly Phe Leu Ala Gln Glu Glu Leu Leu Pro Lys Arg Val Ile Asn Leu 
                165                 170                 175     


Tyr Gln Met Thr Pro Glu Met Trp Glu Glu Arg Ile Thr Ala Trp Tyr 
            180                 185                 190         


Ala Glu His Arg Gly Arg Ala Arg Asp Glu Ala Glu Met Glu Tyr Leu 
        195                 200                 205             


Lys Ile Ala Gln Asp Leu Glu Met Tyr Gly Val Asn Tyr Phe Ala Ile 
    210                 215                 220                 


Arg Asn Lys Lys Gly Thr Glu Leu Leu Leu Gly Val Asp Ala Leu Gly 
225                 230                 235                 240 


Leu His Ile Tyr Asp Pro Glu Asn Arg Leu Thr Pro Lys Ile Ser Phe 
                245                 250                 255     


Pro Trp Asn Glu Ile Arg Asn Ile Ser Tyr Ser Asp Lys Glu Phe Thr 
            260                 265                 270         


Ile Lys Pro Leu Asp Lys Lys Ile Asp Val Phe Lys Phe Asn Ser Ser 
        275                 280                 285             


Lys Leu Arg Val Asn Lys Leu Ile Leu Gln Leu Cys Ile Gly Asn His 
    290                 295                 300                 


Asp Leu Phe Met Arg Arg Arg Lys Ala Asp Ser Leu Glu Val Gln Gln 
305                 310                 315                 320 


Met Lys Ala Gln Ala Arg Glu Glu Lys Ala Arg Lys Gln Met Glu Arg 
                325                 330                 335     


Gln Arg Leu Ala Arg Glu Lys Gln Met Arg Glu Glu Ala Glu Arg Thr 
            340                 345                 350         


Arg Asp Glu Leu Glu Arg Arg Leu Leu Gln Met Lys Glu Glu Ala Thr 
        355                 360                 365             


Met Ala Asn Glu Ala Leu Met Arg Ser Glu Glu Thr Ala Asp Leu Leu 
    370                 375                 380                 


Ala Glu Lys Ala Gln Ile Thr Glu Glu Glu Ala Lys Leu Leu Ala Gln 
385                 390                 395                 400 


Lys Ala Ala Glu Ala Glu Gln Glu Met Gln Arg Ile Lys Ala Thr Ala 
                405                 410                 415     


Ile Arg Thr Glu Glu Glu Lys Arg Leu Met Glu Gln Lys Val Leu Glu 
            420                 425                 430         


Ala Glu Val Leu Ala Leu Lys Met Ala Glu Glu Ser Glu Arg Arg Ala 
        435                 440                 445             


Lys Glu Ala Asp Gln Leu Lys Gln Asp Leu Gln Glu Ala Arg Glu Ala 
    450                 455                 460                 


Glu Arg Arg Ala Lys Gln Lys Leu Leu Glu Ile Ala Thr Lys Pro Thr 
465                 470                 475                 480 


Tyr Pro Pro Met Asn Pro Ile Pro Ala Pro Leu Pro Pro Asp Ile Pro 
                485                 490                 495     


Ser Phe Asn Leu Ile Gly Asp Ser Leu Ser Phe Asp Phe Lys Asp Thr 
            500                 505                 510         


Asp Met Lys Arg Leu Ser Met Glu Ile Glu Lys Glu Lys Val Glu Tyr 
        515                 520                 525             


Met Glu Lys Ser Lys His Leu Gln Glu Gln Leu Asn Glu Leu Lys Thr 
    530                 535                 540                 


Glu Ile Glu Ala Leu Lys Leu Lys Glu Arg Glu Thr Ala Leu Asp Ile 
545                 550                 555                 560 


Leu His Asn Glu Asn Ser Asp Arg Gly Gly Ser Ser Lys His Asn Thr 
                565                 570                 575     


Ile Lys Lys Leu Thr Leu Gln Ser Ala Lys Ser Arg Val Ala Phe Phe 
            580                 585                 590         


Glu Glu Leu 
        595 


<210>  16
<211>  1888
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Synthetic


<220>
<221>  misc_feature
<223>  NF2-S518A Construct

<400>  16
aaagggctca gagtgcaggc cgtggggcgc gagggtcccg ggcctgagcc ccgcgccatg       60

gccggggcca tcgcttcccg catgagcttc agctctctca agaggaagca acccaagacg      120

ttcaccgtga ggatcgtcac catggacgcc gagatggagt tcaattgcga gatgaagtgg      180

aaagggaagg acctctttga tttggtgtgc cggactctgg ggctccgaga aacctggttc      240

tttggactgc agtacacaat caaggacaca gtggcctggc tcaaaatgga caagaaggta      300

ctggatcatg atgtttcaaa ggaagaacca gtcacctttc acttcttggc caaattttat      360

cctgagaatg ctgaagagga gctggttcag gagatcacac aacatttatt cttcttacag      420

gtaaagaagc agattttaga tgaaaagatc tactgccctc ctgaggcttc tgtgctcctg      480

gcttcttacg ccgtccaggc caagtatggt gactacgacc ccagtgttca caagcgggga      540

tttttggccc aagaggaatt gcttccaaaa agggtaataa atctgtatca gatgactccg      600

gaaatgtggg aggagagaat tactgcttgg tacgcagagc accgaggccg agccagggat      660

gaagctgaaa tggaatatct gaagatagct caggacctgg agatgtacgg tgtgaactac      720

tttgcaatcc ggaataaaaa gggcacagag ctgctgcttg gagtggatgc cctggggctt      780

cacatttatg accctgagaa cagactgacc cccaagatct ccttcccgtg gaatgaaatc      840

cgaaacatct cgtacagtga caaggagttt actattaaac cactggataa gaaaattgat      900

gtcttcaagt ttaactcctc aaagcttcgt gttaataagc tgattctcca gctatgtatc      960

gggaaccatg atctatttat gaggagaagg aaagccgatt ctttggaagt tcagcagatg     1020

aaagcccagg ccagggagga gaaggctaga aagcagatgg agcggcagcg cctcgctcga     1080

gagaagcaga tgagggagga ggctgaacgc acgagggatg agttggagag gaggctgctg     1140

cagatgaaag aagaagcaac aatggccaac gaagcactga tgcggtctga ggagacagct     1200

gacctgttgg ctgaaaaggc ccagatcacc gaggaggagg caaaacttct ggcccagaag     1260

gccgcagagg ctgagcagga aatgcagcgc atcaaggcca cagcgattcg cacggaggag     1320

gagaagcgcc tgatggagca gaaggtgctg gaagccgagg tgctggcact gaagatggct     1380

gaggagtcag agaggagggc caaagaggca gatcagctga agcaggacct gcaggaagca     1440

cgcgaggcgg agcgaagagc caagcagaag ctcctggaga ttgccaccaa gcccacgtac     1500

ccgcccatga acccaattcc agcaccgttg cctcctgaca taccaagctt caacctcatt     1560

ggtgacagcc tgtctttcga cttcaaagat actgacatga agcggcttgc catggagata     1620

gagaaagaaa aagtggaata catggaaaag agcaagcatc tgcaggagca gctcaatgaa     1680

ctcaagacag aaatcgaggc cttgaaactg aaagagaggg agacagctct ggatattctg     1740

cacaatgaga actccgacag gggtggcagc agcaagcaca ataccattaa aaagctcacc     1800

ttgcagagcg ccaagtcccg agtggccttc tttgaagagc tctagcaggt gacccagcca     1860

ccccaggacc tgccacttct cctgctac                                        1888


<210>  17
<211>  2483
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Synthetic


<220>
<221>  misc_feature
<223>  NF2-400bp- NF2S518A Expression cassette

<220>
<221>  misc_feature
<222>  (1)..(400)
<223>  NF2 400bp Promoter

<220>
<221>  misc_feature
<222>  (413)..(512)
<223>  SV40 Intron

<220>
<221>  misc_feature
<222>  (530)..(2137)
<223>  NF2S518A

<220>
<221>  misc_feature
<222>  (2139)..(2417)
<223>  NF2S518A

<220>
<221>  misc_feature
<222>  (2435)..(2483)
<223>  Poly A

<400>  17
aagagtccct ccctgggcca acgaaggacc caattcccct cgccccggat ccagcctcta       60

agtggtttcc cgggtaaggt cagcagaggt ccgccgcctc aaccagtctt gttagagtag      120

gcacaaaagc attcagagtg actgccactg tagccactca acgccgagcc taggcctgct      180

ttttttgcag ttagagtgaa actttccatt ggtggagtca ccccaaagga ggcgggacgg      240

agcgggaaag tcctgcctac cttggccttc ccagccaatc gcagcatcta tgcgtcagcc      300

tccggttcgg ttgcgctgcg cgtagtggtc tgggcgacct gagggcgggg ccgggagcag      360

gccccgggct gtggggaggg tgcgcttccc gcgggcgcgc ctgcagataa ctggtaagtt      420

tagtcttttt tgtcttttat ttcaggtccc ggatccggtg gtggtgcaaa tcaaagaact      480

gctcctcagt cgatgttgcc tttacttcta ggcctgtacg gaaaccggta aagggctcag      540

agtgcaggcc gtggggcgcg agggtcccgg gcctgagccc cgcgccatgg ccggggccat      600

cgcttcccgc atgagcttca gctctctcaa gaggaagcaa cccaagacgt tcaccgtgag      660

gatcgtcacc atggacgccg agatggagtt caattgcgag atgaagtgga aagggaagga      720

cctctttgat ttggtgtgcc ggactctggg gctccgagaa acctggttct ttggactgca      780

gtacacaatc aaggacacag tggcctggct caaaatggac aagaaggtac tggatcatga      840

tgtttcaaag gaagaaccag tcacctttca cttcttggcc aaattttatc ctgagaatgc      900

tgaagaggag ctggttcagg agatcacaca acatttattc ttcttacagg taaagaagca      960

gattttagat gaaaagatct actgccctcc tgaggcttct gtgctcctgg cttcttacgc     1020

cgtccaggcc aagtatggtg actacgaccc cagtgttcac aagcggggat ttttggccca     1080

agaggaattg cttccaaaaa gggtaataaa tctgtatcag atgactccgg aaatgtggga     1140

ggagagaatt actgcttggt acgcagagca ccgaggccga gccagggatg aagctgaaat     1200

ggaatatctg aagatagctc aggacctgga gatgtacggt gtgaactact ttgcaatccg     1260

gaataaaaag ggcacagagc tgctgcttgg agtggatgcc ctggggcttc acatttatga     1320

ccctgagaac agactgaccc ccaagatctc cttcccgtgg aatgaaatcc gaaacatctc     1380

gtacagtgac aaggagttta ctattaaacc actggataag aaaattgatg tcttcaagtt     1440

taactcctca aagcttcgtg ttaataagct gattctccag ctatgtatcg ggaaccatga     1500

tctatttatg aggagaagga aagccgattc tttggaagtt cagcagatga aagcccaggc     1560

cagggaggag aaggctagaa agcagatgga gcggcagcgc ctcgctcgag agaagcagat     1620

gagggaggag gctgaacgca cgagggatga gttggagagg aggctgctgc agatgaaaga     1680

agaagcaaca atggccaacg aagcactgat gcggtctgag gagacagctg acctgttggc     1740

tgaaaaggcc cagatcaccg aggaggaggc aaaacttctg gcccagaagg ccgcagaggc     1800

tgagcaggaa atgcagcgca tcaaggccac agcgattcgc acggaggagg agaagcgcct     1860

gatggagcag aaggtgctgg aagccgaggt gctggcactg aagatggctg aggagtcaga     1920

gaggagggcc aaagaggcag atcagctgaa gcaggacctg caggaagcac gcgaggcgga     1980

gcgaagagcc aagcagaagc tcctggagat tgccaccaag cccacgtacc cgcccatgaa     2040

cccaattcca gcaccgttgc ctcctgacat accaagcttc aacctcattg gtgacagcct     2100

gtctttcgac ttcaaagata ctgacatgaa gcggcttgcc atggagatag agaaagaaaa     2160

agtggaatac atggaaaaga gcaagcatct gcaggagcag ctcaatgaac tcaagacaga     2220

aatcgaggcc ttgaaactga aagagaggga gacagctctg gatattctgc acaatgagaa     2280

ctccgacagg ggtggcagca gcaagcacaa taccattaaa aagctcacct tgcagagcgc     2340

caagtcccga gtggccttct ttgaagagct ctagcaggtg acccagccac cccaggacct     2400

gccacttctc ctgctactgt acaagtaaaa gcttaataaa agatctttat tttcattaga     2460

tctgtgtgtt ggttttttgt gtg                                             2483


<210>  18
<211>  2687
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Synthetic


<220>
<221>  misc_feature
<223>  NF2-610bp- NF2S518A Expression cassette

<220>
<221>  misc_feature
<222>  (1)..(610)
<223>  NF2 610bp Promoter

<220>
<221>  misc_feature
<222>  (617)..(716)
<223>  SV40 Intron

<220>
<221>  misc_feature
<222>  (734)..(2341)
<223>  NF2S518A

<220>
<221>  misc_feature
<222>  (2343)..(2621)
<223>  NF2S518A

<220>
<221>  misc_feature
<222>  (2639)..(2687)
<223>  Poly A

<400>  18
aagagtccct ccctgggcca acgaaggacc caattcccct cgccccggat ccagcctcta       60

agtggtttcc cgggtaaggt cagcagaggt ccgccgcctc aaccagtctt gttagagtag      120

gcacaaaagc attcagagtg actgccactg tagccactca acgccgagcc taggcctgct      180

ttttttgcag ttagagtgaa actttccatt ggtggagtca ccccaaagga ggcgggacgg      240

agcgggaaag tcctgcctac cttggccttc ccagccaatc gcagcatcta tgcgtcagcc      300

tccggttcgg ttgcgctgcg cgtagtggtc tgggcgacct gagggcgggg ccgggagcag      360

gccccgggct gtggggaggg tgcgcttccc gcgggcgcgc ggagtgagga cggtgacagc      420

cacgcgcgcg cgtacgcgcc cgatgcagcg cggccccgtg accctagtcg gccgctgaga      480

ggcgcgcgga gtctgggccg ctgccgtcta ggggtcccgt cccgaggcgt ccccggcatc      540

tccggcccga atcccggagt gccgggtcgc gcctgcaccg aaggtcccgg ctcctgtgcc      600

ctccctgcag ataactggta agtttagtct tttttgtctt ttatttcagg tcccggatcc      660

ggtggtggtg caaatcaaag aactgctcct cagtcgatgt tgcctttact tctaggcctg      720

tacggaaacc ggtaaagggc tcagagtgca ggccgtgggg cgcgagggtc ccgggcctga      780

gccccgcgcc atggccgggg ccatcgcttc ccgcatgagc ttcagctctc tcaagaggaa      840

gcaacccaag acgttcaccg tgaggatcgt caccatggac gccgagatgg agttcaattg      900

cgagatgaag tggaaaggga aggacctctt tgatttggtg tgccggactc tggggctccg      960

agaaacctgg ttctttggac tgcagtacac aatcaaggac acagtggcct ggctcaaaat     1020

ggacaagaag gtactggatc atgatgtttc aaaggaagaa ccagtcacct ttcacttctt     1080

ggccaaattt tatcctgaga atgctgaaga ggagctggtt caggagatca cacaacattt     1140

attcttctta caggtaaaga agcagatttt agatgaaaag atctactgcc ctcctgaggc     1200

ttctgtgctc ctggcttctt acgccgtcca ggccaagtat ggtgactacg accccagtgt     1260

tcacaagcgg ggatttttgg cccaagagga attgcttcca aaaagggtaa taaatctgta     1320

tcagatgact ccggaaatgt gggaggagag aattactgct tggtacgcag agcaccgagg     1380

ccgagccagg gatgaagctg aaatggaata tctgaagata gctcaggacc tggagatgta     1440

cggtgtgaac tactttgcaa tccggaataa aaagggcaca gagctgctgc ttggagtgga     1500

tgccctgggg cttcacattt atgaccctga gaacagactg acccccaaga tctccttccc     1560

gtggaatgaa atccgaaaca tctcgtacag tgacaaggag tttactatta aaccactgga     1620

taagaaaatt gatgtcttca agtttaactc ctcaaagctt cgtgttaata agctgattct     1680

ccagctatgt atcgggaacc atgatctatt tatgaggaga aggaaagccg attctttgga     1740

agttcagcag atgaaagccc aggccaggga ggagaaggct agaaagcaga tggagcggca     1800

gcgcctcgct cgagagaagc agatgaggga ggaggctgaa cgcacgaggg atgagttgga     1860

gaggaggctg ctgcagatga aagaagaagc aacaatggcc aacgaagcac tgatgcggtc     1920

tgaggagaca gctgacctgt tggctgaaaa ggcccagatc accgaggagg aggcaaaact     1980

tctggcccag aaggccgcag aggctgagca ggaaatgcag cgcatcaagg ccacagcgat     2040

tcgcacggag gaggagaagc gcctgatgga gcagaaggtg ctggaagccg aggtgctggc     2100

actgaagatg gctgaggagt cagagaggag ggccaaagag gcagatcagc tgaagcagga     2160

cctgcaggaa gcacgcgagg cggagcgaag agccaagcag aagctcctgg agattgccac     2220

caagcccacg tacccgccca tgaacccaat tccagcaccg ttgcctcctg acataccaag     2280

cttcaacctc attggtgaca gcctgtcttt cgacttcaaa gatactgaca tgaagcggct     2340

tgccatggag atagagaaag aaaaagtgga atacatggaa aagagcaagc atctgcagga     2400

gcagctcaat gaactcaaga cagaaatcga ggccttgaaa ctgaaagaga gggagacagc     2460

tctggatatt ctgcacaatg agaactccga caggggtggc agcagcaagc acaataccat     2520

taaaaagctc accttgcaga gcgccaagtc ccgagtggcc ttctttgaag agctctagca     2580

ggtgacccag ccaccccagg acctgccact tctcctgcta ctgtacaagt aaaagcttaa     2640

taaaagatct ttattttcat tagatctgtg tgttggtttt ttgtgtg                   2687


<210>  19
<211>  4174
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Synthetic


<220>
<221>  misc_feature
<223>  NF2-2.1kb- NF2S518A Expression cassette

<220>
<221>  misc_feature
<222>  (1)..(2091)
<223>  NF2 2.1kb Promoter

<220>
<221>  misc_feature
<222>  (2104)..(2203)
<223>  SV40 Intron

<220>
<221>  misc_feature
<222>  (2221)..(3828)
<223>  NF2S518A

<220>
<221>  misc_feature
<222>  (3830)..(4108)
<223>  NF2S518A

<220>
<221>  misc_feature
<222>  (4126)..(4174)
<223>  Poly A

<400>  19
cccggtgtca cgtattttta tcagcagcca tttgttgtcc ctgtggggag cccagaaaac       60

ccagcccggt tctcccacct gcggggaaga aatgaagcaa tgataatgaa gacactccca      120

tgccaagccc atactgccct gagcaatcag ttttggtggg gagaatttgc tagcagaagg      180

caggacataa agtccccaca gcagcctcac tgggtgtggc agcaaatcat tcctgaggcc      240

tggccggtgc taccaggcac agcaggggtc cgtgcagaag aactagattt attccattaa      300

tataccgtta cagcaacaat gtctgctgag tactccggaa ctgtaattca catttcctga      360

ggctgtagta gggagaattt ggaagcaggg cagcacagtg ctaaccagca ggctctgggt      420

gggacagacc tgggtttgag tcctagcttt gcctttcact atctgcatta tagtcagcga      480

gtggctctat catatctctc agtatcttca cctgtggagt tgggggggtg atgctaatgt      540

tagctaacat ttatggggtg attattgttg ttaaaactca gtacaccggg cgcggtggct      600

cacgcctgta atcccagcac tttgggaggc caaggtgggc agatcacctg aggtcagaag      660

tttgagacca gcctggctaa catggtgaaa ccccgtccct actaaaaata caaaaattag      720

ccgggcgtgg tggcgggtgc ctgtaatccc aactactggg gaggctgagg caggagaatt      780

gcttgaaccc gggaggcgga ggttgcagag agccgagacc gccccattgt actccagcct      840

gggcaacaag agcgaaactc tgtctcaaaa caaaaaacaa acgaaaaaac acagtaaatt      900

gtccctattt gactactaag agctatttta aaatagaatt tattatctaa gtacagaaag      960

gtgtaattat cccccctaca cccgttagaa cccttgatga cactaaataa ataatacatg     1020

aatacggttc aaaaatgggc atcatagagt ataaaataaa gaatgctttc attttcaacc     1080

caaattcagc aatttcatag gatgccaggc tcagctctaa agccttatat gtattcagtg     1140

cgctgaaatt caacaacctc acgaggtagg tataaccaat aataattcta ggcggggcgt     1200

ggtggctcac gcctgtaatc ctagcacttc gggaggccga ggcgggcgga tcacctgagg     1260

ttcgagacca gcctgacgaa catggagaaa ccccgtctct aataaaaata caaaattagc     1320

cgggcgtggt gacgcatacc tgtaatccca gctactcggg aggctgacgc cggaaaatcg     1380

cttgaacccg ggaggcggag gttgcagtga gccgagatcg cgccactgca ctccagcctg     1440

ggcaacaaga gcgaaactcc gtcccaataa taataataat taataataat aataataaca     1500

ataataataa taattctaaa gggaagcaga gggatctggc gggaaagtgc cagcaaacct     1560

aacaggcctc cacaagtgtc tttaaagttt cataggggtc ggtatatgtg attaactgcc     1620

aaagaagaat attcgccgtg tgtccgaaac gcagtcccct ggggcgccac actcggagcc     1680

tacttgaacc gaagagtccc tccctgggcc aacgaaggac ccaattcccc tcgccccgga     1740

tccagcctct aagtggtttc ccgggtaagg tcagcagagg tccgccgcct caaccagtct     1800

tgttagagta ggcacaaaag cattcagagt gactgccact gtagccactc aacgccgagc     1860

ctaggcctgc tttttttgca gttagagtga aactttccat tggtggagtc accccaaagg     1920

aggcgggacg gagcgggaaa gtcctgccta ccttggcctt cccagccaat cgcagcatct     1980

atgcgtcagc ctccggttcg gttgcgctgc gcgtagtggt ctgggcgacc tgagggcggg     2040

gccgggagca ggccccgggc tgtggggagg gtgcgcttcc cgcgggcgcg cctgcagata     2100

actggtaagt ttagtctttt ttgtctttta tttcaggtcc cggatccggt ggtggtgcaa     2160

atcaaagaac tgctcctcag tcgatgttgc ctttacttct aggcctgtac ggaaaccggt     2220

aaagggctca gagtgcaggc cgtggggcgc gagggtcccg ggcctgagcc ccgcgccatg     2280

gccggggcca tcgcttcccg catgagcttc agctctctca agaggaagca acccaagacg     2340

ttcaccgtga ggatcgtcac catggacgcc gagatggagt tcaattgcga gatgaagtgg     2400

aaagggaagg acctctttga tttggtgtgc cggactctgg ggctccgaga aacctggttc     2460

tttggactgc agtacacaat caaggacaca gtggcctggc tcaaaatgga caagaaggta     2520

ctggatcatg atgtttcaaa ggaagaacca gtcacctttc acttcttggc caaattttat     2580

cctgagaatg ctgaagagga gctggttcag gagatcacac aacatttatt cttcttacag     2640

gtaaagaagc agattttaga tgaaaagatc tactgccctc ctgaggcttc tgtgctcctg     2700

gcttcttacg ccgtccaggc caagtatggt gactacgacc ccagtgttca caagcgggga     2760

tttttggccc aagaggaatt gcttccaaaa agggtaataa atctgtatca gatgactccg     2820

gaaatgtggg aggagagaat tactgcttgg tacgcagagc accgaggccg agccagggat     2880

gaagctgaaa tggaatatct gaagatagct caggacctgg agatgtacgg tgtgaactac     2940

tttgcaatcc ggaataaaaa gggcacagag ctgctgcttg gagtggatgc cctggggctt     3000

cacatttatg accctgagaa cagactgacc cccaagatct ccttcccgtg gaatgaaatc     3060

cgaaacatct cgtacagtga caaggagttt actattaaac cactggataa gaaaattgat     3120

gtcttcaagt ttaactcctc aaagcttcgt gttaataagc tgattctcca gctatgtatc     3180

gggaaccatg atctatttat gaggagaagg aaagccgatt ctttggaagt tcagcagatg     3240

aaagcccagg ccagggagga gaaggctaga aagcagatgg agcggcagcg cctcgctcga     3300

gagaagcaga tgagggagga ggctgaacgc acgagggatg agttggagag gaggctgctg     3360

cagatgaaag aagaagcaac aatggccaac gaagcactga tgcggtctga ggagacagct     3420

gacctgttgg ctgaaaaggc ccagatcacc gaggaggagg caaaacttct ggcccagaag     3480

gccgcagagg ctgagcagga aatgcagcgc atcaaggcca cagcgattcg cacggaggag     3540

gagaagcgcc tgatggagca gaaggtgctg gaagccgagg tgctggcact gaagatggct     3600

gaggagtcag agaggagggc caaagaggca gatcagctga agcaggacct gcaggaagca     3660

cgcgaggcgg agcgaagagc caagcagaag ctcctggaga ttgccaccaa gcccacgtac     3720

ccgcccatga acccaattcc agcaccgttg cctcctgaca taccaagctt caacctcatt     3780

ggtgacagcc tgtctttcga cttcaaagat actgacatga agcggcttgc catggagata     3840

gagaaagaaa aagtggaata catggaaaag agcaagcatc tgcaggagca gctcaatgaa     3900

ctcaagacag aaatcgaggc cttgaaactg aaagagaggg agacagctct ggatattctg     3960

cacaatgaga actccgacag gggtggcagc agcaagcaca ataccattaa aaagctcacc     4020

ttgcagagcg ccaagtcccg agtggccttc tttgaagagc tctagcaggt gacccagcca     4080

ccccaggacc tgccacttct cctgctactg tacaagtaaa agcttaataa aagatcttta     4140

ttttcattag atctgtgtgt tggttttttg tgtg                                 4174


<210>  20
<211>  4378
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Synthetic


<220>
<221>  misc_feature
<223>  2.3kb-NF2S518A Expression cassette

<220>
<221>  misc_feature
<222>  (1)..(2301)
<223>  NF2 2.3kb Promoter

<220>
<221>  misc_feature
<222>  (2308)..(2407)
<223>  SV40 Intron

<220>
<221>  misc_feature
<222>  (2425)..(4032)
<223>  NF2S518A

<220>
<221>  misc_feature
<222>  (4034)..(4312)
<223>  NF2S518A

<220>
<221>  misc_feature
<222>  (4330)..(4378)
<223>  Poly A

<400>  20
cccggtgtca cgtattttta tcagcagcca tttgttgtcc ctgtggggag cccagaaaac       60

ccagcccggt tctcccacct gcggggaaga aatgaagcaa tgataatgaa gacactccca      120

tgccaagccc atactgccct gagcaatcag ttttggtggg gagaatttgc tagcagaagg      180

caggacataa agtccccaca gcagcctcac tgggtgtggc agcaaatcat tcctgaggcc      240

tggccggtgc taccaggcac agcaggggtc cgtgcagaag aactagattt attccattaa      300

tataccgtta cagcaacaat gtctgctgag tactccggaa ctgtaattca catttcctga      360

ggctgtagta gggagaattt ggaagcaggg cagcacagtg ctaaccagca ggctctgggt      420

gggacagacc tgggtttgag tcctagcttt gcctttcact atctgcatta tagtcagcga      480

gtggctctat catatctctc agtatcttca cctgtggagt tgggggggtg atgctaatgt      540

tagctaacat ttatggggtg attattgttg ttaaaactca gtacaccggg cgcggtggct      600

cacgcctgta atcccagcac tttgggaggc caaggtgggc agatcacctg aggtcagaag      660

tttgagacca gcctggctaa catggtgaaa ccccgtccct actaaaaata caaaaattag      720

ccgggcgtgg tggcgggtgc ctgtaatccc aactactggg gaggctgagg caggagaatt      780

gcttgaaccc gggaggcgga ggttgcagag agccgagacc gccccattgt actccagcct      840

gggcaacaag agcgaaactc tgtctcaaaa caaaaaacaa acgaaaaaac acagtaaatt      900

gtccctattt gactactaag agctatttta aaatagaatt tattatctaa gtacagaaag      960

gtgtaattat cccccctaca cccgttagaa cccttgatga cactaaataa ataatacatg     1020

aatacggttc aaaaatgggc atcatagagt ataaaataaa gaatgctttc attttcaacc     1080

caaattcagc aatttcatag gatgccaggc tcagctctaa agccttatat gtattcagtg     1140

cgctgaaatt caacaacctc acgaggtagg tataaccaat aataattcta ggcggggcgt     1200

ggtggctcac gcctgtaatc ctagcacttc gggaggccga ggcgggcgga tcacctgagg     1260

ttcgagacca gcctgacgaa catggagaaa ccccgtctct aataaaaata caaaattagc     1320

cgggcgtggt gacgcatacc tgtaatccca gctactcggg aggctgacgc cggaaaatcg     1380

cttgaacccg ggaggcggag gttgcagtga gccgagatcg cgccactgca ctccagcctg     1440

ggcaacaaga gcgaaactcc gtcccaataa taataataat taataataat aataataaca     1500

ataataataa taattctaaa gggaagcaga gggatctggc gggaaagtgc cagcaaacct     1560

aacaggcctc cacaagtgtc tttaaagttt cataggggtc ggtatatgtg attaactgcc     1620

aaagaagaat attcgccgtg tgtccgaaac gcagtcccct ggggcgccac actcggagcc     1680

tacttgaacc gaagagtccc tccctgggcc aacgaaggac ccaattcccc tcgccccgga     1740

tccagcctct aagtggtttc ccgggtaagg tcagcagagg tccgccgcct caaccagtct     1800

tgttagagta ggcacaaaag cattcagagt gactgccact gtagccactc aacgccgagc     1860

ctaggcctgc tttttttgca gttagagtga aactttccat tggtggagtc accccaaagg     1920

aggcgggacg gagcgggaaa gtcctgccta ccttggcctt cccagccaat cgcagcatct     1980

atgcgtcagc ctccggttcg gttgcgctgc gcgtagtggt ctgggcgacc tgagggcggg     2040

gccgggagca ggccccgggc tgtggggagg gtgcgcttcc cgcgggcgcg cggagtgagg     2100

acggtgacag ccacgcgcgc gcgtacgcgc ccgatgcagc gcggccccgt gaccctagtc     2160

ggccgctgag aggcgcgcgg agtctgggcc gctgccgtct aggggtcccg tcccgaggcg     2220

tccccggcat ctccggcccg aatcccggag tgccgggtcg cgcctgcacc gaaggtcccg     2280

gctcctgtgc cctccctgca gataactggt aagtttagtc ttttttgtct tttatttcag     2340

gtcccggatc cggtggtggt gcaaatcaaa gaactgctcc tcagtcgatg ttgcctttac     2400

ttctaggcct gtacggaaac cggtaaaggg ctcagagtgc aggccgtggg gcgcgagggt     2460

cccgggcctg agccccgcgc catggccggg gccatcgctt cccgcatgag cttcagctct     2520

ctcaagagga agcaacccaa gacgttcacc gtgaggatcg tcaccatgga cgccgagatg     2580

gagttcaatt gcgagatgaa gtggaaaggg aaggacctct ttgatttggt gtgccggact     2640

ctggggctcc gagaaacctg gttctttgga ctgcagtaca caatcaagga cacagtggcc     2700

tggctcaaaa tggacaagaa ggtactggat catgatgttt caaaggaaga accagtcacc     2760

tttcacttct tggccaaatt ttatcctgag aatgctgaag aggagctggt tcaggagatc     2820

acacaacatt tattcttctt acaggtaaag aagcagattt tagatgaaaa gatctactgc     2880

cctcctgagg cttctgtgct cctggcttct tacgccgtcc aggccaagta tggtgactac     2940

gaccccagtg ttcacaagcg gggatttttg gcccaagagg aattgcttcc aaaaagggta     3000

ataaatctgt atcagatgac tccggaaatg tgggaggaga gaattactgc ttggtacgca     3060

gagcaccgag gccgagccag ggatgaagct gaaatggaat atctgaagat agctcaggac     3120

ctggagatgt acggtgtgaa ctactttgca atccggaata aaaagggcac agagctgctg     3180

cttggagtgg atgccctggg gcttcacatt tatgaccctg agaacagact gacccccaag     3240

atctccttcc cgtggaatga aatccgaaac atctcgtaca gtgacaagga gtttactatt     3300

aaaccactgg ataagaaaat tgatgtcttc aagtttaact cctcaaagct tcgtgttaat     3360

aagctgattc tccagctatg tatcgggaac catgatctat ttatgaggag aaggaaagcc     3420

gattctttgg aagttcagca gatgaaagcc caggccaggg aggagaaggc tagaaagcag     3480

atggagcggc agcgcctcgc tcgagagaag cagatgaggg aggaggctga acgcacgagg     3540

gatgagttgg agaggaggct gctgcagatg aaagaagaag caacaatggc caacgaagca     3600

ctgatgcggt ctgaggagac agctgacctg ttggctgaaa aggcccagat caccgaggag     3660

gaggcaaaac ttctggccca gaaggccgca gaggctgagc aggaaatgca gcgcatcaag     3720

gccacagcga ttcgcacgga ggaggagaag cgcctgatgg agcagaaggt gctggaagcc     3780

gaggtgctgg cactgaagat ggctgaggag tcagagagga gggccaaaga ggcagatcag     3840

ctgaagcagg acctgcagga agcacgcgag gcggagcgaa gagccaagca gaagctcctg     3900

gagattgcca ccaagcccac gtacccgccc atgaacccaa ttccagcacc gttgcctcct     3960

gacataccaa gcttcaacct cattggtgac agcctgtctt tcgacttcaa agatactgac     4020

atgaagcggc ttgccatgga gatagagaaa gaaaaagtgg aatacatgga aaagagcaag     4080

catctgcagg agcagctcaa tgaactcaag acagaaatcg aggccttgaa actgaaagag     4140

agggagacag ctctggatat tctgcacaat gagaactccg acaggggtgg cagcagcaag     4200

cacaatacca ttaaaaagct caccttgcag agcgccaagt cccgagtggc cttctttgaa     4260

gagctctagc aggtgaccca gccaccccag gacctgccac ttctcctgct actgtacaag     4320

taaaagctta ataaaagatc tttattttca ttagatctgt gtgttggttt tttgtgtg       4378


<210>  21
<211>  34
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Synthetic


<220>
<221>  misc_feature
<223>  NF2 2381 Fw KpnI

<400>  21
ttttttggta cccccggtgt cacgtatttt tatc                                   34


<210>  22
<211>  30
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Synthetic


<220>
<221>  misc_feature
<223>  NF2 2381 Rv PstI

<400>  22
ttttttctgc agctgcgcgg gtccccagcg                                        30


<210>  23
<211>  34
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Synthetic


<220>
<221>  misc_feature
<223>  NF2 400 Fw KpnI

<400>  23
ttttttggta ccaagagtcc ctccctgggc caac                                   34


<210>  24
<211>  30
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Synthetic


<220>
<221>  misc_feature
<223>  NF2 400 Rv PstI

<400>  24
ttttttctgc aggcgcgccc gcgggaagcg                                        30


<210>  25
<211>  31
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Synthetic


<220>
<221>  misc_feature
<223>  NF2-cDNA-AgeI-Fwd

<400>  25
tttttaccgg ttaaagggct cagagtgcag g                                      31


<210>  26
<211>  31
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Synthetic


<220>
<221>  misc_feature
<223>  NF2-cDNA-BsrGI-Rev

<400>  26
ttttttgtac agtagcagga gaagtggcag g                                      31


<210>  27
<211>  20
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Synthetic


<220>
<221>  misc_feature
<223>  Total NF2-Fwd

<400>  27
tgcgagatga agtggaaagg                                                   20


<210>  28
<211>  20
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Synthetic


<220>
<221>  misc_feature
<223>  Total NF2-Rev

<400>  28
gccaagaagt gaaaggtgac                                                   20


<210>  29
<211>  20
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Synthetic


<220>
<221>  misc_feature
<223>  NF2 isoform 1-Fwd

<400>  29
ccttgaaact gaaagagagg                                                   20


<210>  30
<211>  20
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Synthetic


<220>
<221>  misc_feature
<223>  NF2 isoform 1-Rev

<400>  30
caaggtgagc tttttaatgg                                                   20


<210>  31
<211>  20
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Synthetic


<220>
<221>  misc_feature
<223>  Vector-specific NF2-Fwd

<400>  31
tggtggtgca aatcaaagaa                                                   20


<210>  32
<211>  18
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Synthetic


<220>
<221>  misc_feature
<223>  Vector-specific NF2-Rev

<400>  32
cgatcctcac ggtgaacg                                                     18


<210>  33
<211>  19
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Synthetic


<220>
<221>  misc_feature
<223>  FN1-Fwd

<400>  33
caagccagat gtcagaagc                                                    19


<210>  34
<211>  19
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Synthetic


<220>
<221>  misc_feature
<223>  FN1-Rev

<400>  34
ggatggtgca tcaatggca                                                    19


<210>  35
<211>  19
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Synthetic


<220>
<221>  misc_feature
<223>  Col3a1-Fwd

<400>  35
ccctggatct ccaggatac                                                    19


<210>  36
<211>  19
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Synthetic


<220>
<221>  misc_feature
<223>  Col3a1-Rev

<400>  36
gtccgggtct acctgattc                                                    19


<210>  37
<211>  24
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Synthetic


<220>
<221>  misc_feature
<223>  KROX20-Fwd

<400>  37
caccagctgt ctgacaacat ctac                                              24


<210>  38
<211>  20
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Synthetic


<220>
<221>  misc_feature
<223>  KROX20-Rev

<400>  38
cctgcacagc cagaataagg                                                   20


<210>  39
<211>  23
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Synthetic


<220>
<221>  misc_feature
<223>  MBP-Fwd

<400>  39
ttaagctggg aggaagagat agt                                               23


<210>  40
<211>  20
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Synthetic


<220>
<221>  misc_feature
<223>  MBP-Rev

<400>  40
gggaggggtc atctgctcta                                                   20


<210>  41
<211>  23
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Synthetic


<220>
<221>  misc_feature
<223>  GAPDH-Fwd

<400>  41
caactttggt atcgtggaag gac                                               23


<210>  42
<211>  21
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Synthetic


<220>
<221>  misc_feature
<223>  GAPDH-Rev

<400>  42
acagtcttct ggatggcagt g                                                 21


<210>  43
<211>  23
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Synthetic


<220>
<221>  misc_feature
<223>  RPL13A-Fwd

<400>  43
cctggaggag aagaggaaag aga                                               23


<210>  44
<211>  25
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Synthetic


<220>
<221>  misc_feature
<223>  RPL13A-Rev

<400>  44
ttgaggacct ctgtgtattt gtcaa                                             25


<210>  45
<211>  23
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Synthetic


<220>
<221>  misc_feature
<223>  RPL13A-Fwd

<400>  45
cctggaggag aagaggaaag aga                                               23


<210>  46
<211>  25
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Synthetic


<220>
<221>  misc_feature
<223>  RPL13A-Rev

<400>  46
ttgaggacct ctgtgtattt gtcaa                                             25


<210>  47
<211>  21
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Synthetic


<220>
<221>  misc_feature
<223>  Target sequence in NF2 gene

<400>  47
ggatgaagct gaaatggaat a                                                 21


