                         SEQUENCE LISTING

<110>  CAPSIDA, INC.
 
<120>  AAV COMPOSITIONS WITH HIGH BRAIN EXPRESSION FOR TREATING 
       MUCOPOLYSACCHARIDOSIS II

<130>  CAPS-016/01WO 35847/64

<140>  PCT/US22/24641
<141>  2022-04-13

<150>  US 63/174,440
<151>  2021-04-13

<150>  US 63/255,801
<151>  2021-10-14

<160>  199   

<170>  PatentIn version 3.5

<210>  1
<211>  736
<212>  PRT
<213>  adeno-associated virus 9

<400>  1

Met Ala Ala Asp Gly Tyr Leu Pro Asp Trp Leu Glu Asp Asn Leu Ser 
1               5                   10                  15      


Glu Gly Ile Arg Glu Trp Trp Ala Leu Lys Pro Gly Ala Pro Gln Pro 
            20                  25                  30          


Lys Ala Asn Gln Gln His Gln Asp Asn Ala Arg Gly Leu Val Leu Pro 
        35                  40                  45              


Gly Tyr Lys Tyr Leu Gly Pro Gly Asn Gly Leu Asp Lys Gly Glu Pro 
    50                  55                  60                  


Val Asn Ala Ala Asp Ala Ala Ala Leu Glu His Asp Lys Ala Tyr Asp 
65                  70                  75                  80  


Gln Gln Leu Lys Ala Gly Asp Asn Pro Tyr Leu Lys Tyr Asn His Ala 
                85                  90                  95      


Asp Ala Glu Phe Gln Glu Arg Leu Lys Glu Asp Thr Ser Phe Gly Gly 
            100                 105                 110         


Asn Leu Gly Arg Ala Val Phe Gln Ala Lys Lys Arg Leu Leu Glu Pro 
        115                 120                 125             


Leu Gly Leu Val Glu Glu Ala Ala Lys Thr Ala Pro Gly Lys Lys Arg 
    130                 135                 140                 


Pro Val Glu Gln Ser Pro Gln Glu Pro Asp Ser Ser Ala Gly Ile Gly 
145                 150                 155                 160 


Lys Ser Gly Ala Gln Pro Ala Lys Lys Arg Leu Asn Phe Gly Gln Thr 
                165                 170                 175     


Gly Asp Thr Glu Ser Val Pro Asp Pro Gln Pro Ile Gly Glu Pro Pro 
            180                 185                 190         


Ala Ala Pro Ser Gly Val Gly Ser Leu Thr Met Ala Ser Gly Gly Gly 
        195                 200                 205             


Ala Pro Val Ala Asp Asn Asn Glu Gly Ala Asp Gly Val Gly Ser Ser 
    210                 215                 220                 


Ser Gly Asn Trp His Cys Asp Ser Gln Trp Leu Gly Asp Arg Val Ile 
225                 230                 235                 240 


Thr Thr Ser Thr Arg Thr Trp Ala Leu Pro Thr Tyr Asn Asn His Leu 
                245                 250                 255     


Tyr Lys Gln Ile Ser Asn Ser Thr Ser Gly Gly Ser Ser Asn Asp Asn 
            260                 265                 270         


Ala Tyr Phe Gly Tyr Ser Thr Pro Trp Gly Tyr Phe Asp Phe Asn Arg 
        275                 280                 285             


Phe His Cys His Phe Ser Pro Arg Asp Trp Gln Arg Leu Ile Asn Asn 
    290                 295                 300                 


Asn Trp Gly Phe Arg Pro Lys Arg Leu Asn Phe Lys Leu Phe Asn Ile 
305                 310                 315                 320 


Gln Val Lys Glu Val Thr Asp Asn Asn Gly Val Lys Thr Ile Ala Asn 
                325                 330                 335     


Asn Leu Thr Ser Thr Val Gln Val Phe Thr Asp Ser Asp Tyr Gln Leu 
            340                 345                 350         


Pro Tyr Val Leu Gly Ser Ala His Glu Gly Cys Leu Pro Pro Phe Pro 
        355                 360                 365             


Ala Asp Val Phe Met Ile Pro Gln Tyr Gly Tyr Leu Thr Leu Asn Asp 
    370                 375                 380                 


Gly Ser Gln Ala Val Gly Arg Ser Ser Phe Tyr Cys Leu Glu Tyr Phe 
385                 390                 395                 400 


Pro Ser Gln Met Leu Arg Thr Gly Asn Asn Phe Gln Phe Ser Tyr Glu 
                405                 410                 415     


Phe Glu Asn Val Pro Phe His Ser Ser Tyr Ala His Ser Gln Ser Leu 
            420                 425                 430         


Asp Arg Leu Met Asn Pro Leu Ile Asp Gln Tyr Leu Tyr Tyr Leu Ser 
        435                 440                 445             


Lys Thr Ile Asn Gly Ser Gly Gln Asn Gln Gln Thr Leu Lys Phe Ser 
    450                 455                 460                 


Val Ala Gly Pro Ser Asn Met Ala Val Gln Gly Arg Asn Tyr Ile Pro 
465                 470                 475                 480 


Gly Pro Ser Tyr Arg Gln Gln Arg Val Ser Thr Thr Val Thr Gln Asn 
                485                 490                 495     


Asn Asn Ser Glu Phe Ala Trp Pro Gly Ala Ser Ser Trp Ala Leu Asn 
            500                 505                 510         


Gly Arg Asn Ser Leu Met Asn Pro Gly Pro Ala Met Ala Ser His Lys 
        515                 520                 525             


Glu Gly Glu Asp Arg Phe Phe Pro Leu Ser Gly Ser Leu Ile Phe Gly 
    530                 535                 540                 


Lys Gln Gly Thr Gly Arg Asp Asn Val Asp Ala Asp Lys Val Met Ile 
545                 550                 555                 560 


Thr Asn Glu Glu Glu Ile Lys Thr Thr Asn Pro Val Ala Thr Glu Ser 
                565                 570                 575     


Tyr Gly Gln Val Ala Thr Asn His Gln Ser Ala Gln Ala Gln Ala Gln 
            580                 585                 590         


Thr Gly Trp Val Gln Asn Gln Gly Ile Leu Pro Gly Met Val Trp Gln 
        595                 600                 605             


Asp Arg Asp Val Tyr Leu Gln Gly Pro Ile Trp Ala Lys Ile Pro His 
    610                 615                 620                 


Thr Asp Gly Asn Phe His Pro Ser Pro Leu Met Gly Gly Phe Gly Met 
625                 630                 635                 640 


Lys His Pro Pro Pro Gln Ile Leu Ile Lys Asn Thr Pro Val Pro Ala 
                645                 650                 655     


Asp Pro Pro Thr Ala Phe Asn Lys Asp Lys Leu Asn Ser Phe Ile Thr 
            660                 665                 670         


Gln Tyr Ser Thr Gly Gln Val Ser Val Glu Ile Glu Trp Glu Leu Gln 
        675                 680                 685             


Lys Glu Asn Ser Lys Arg Trp Asn Pro Glu Ile Gln Tyr Thr Ser Asn 
    690                 695                 700                 


Tyr Tyr Lys Ser Asn Asn Val Glu Phe Ala Val Asn Thr Glu Gly Val 
705                 710                 715                 720 


Tyr Ser Glu Pro Arg Pro Ile Gly Thr Arg Tyr Leu Thr Arg Asn Leu 
                725                 730                 735     


<210>  2
<211>  11
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthesized

<400>  2

Ala Gln Leu Asn Thr Thr Lys Ser Val Met Gln 
1               5                   10      


<210>  3
<211>  11
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthesized

<400>  3

Ala Gln Leu Asn Thr Thr Lys Pro Thr Asp Arg 
1               5                   10      


<210>  4
<211>  11
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthesized

<400>  4

Ala Gln Leu Asn Thr Thr Lys Pro Thr Val Gly 
1               5                   10      


<210>  5
<211>  11
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthesized

<400>  5

Ala Gln Leu Asn Thr Thr Lys Pro Ser Pro Gly 
1               5                   10      


<210>  6
<211>  11
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthesized

<400>  6

Ala Gln Leu Asn Thr Thr Lys Pro Thr Gly Pro 
1               5                   10      


<210>  7
<211>  11
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthesized

<400>  7

Ala Gln Leu Asn Thr Thr Lys Pro Thr Ala Gly 
1               5                   10      


<210>  8
<211>  11
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthesized

<400>  8

Ala Gln Leu Asn Thr Thr Lys Pro Val Ala Gly 
1               5                   10      


<210>  9
<211>  11
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthesized

<400>  9

Ala Gln Leu Asn Thr Thr Lys Asn Ile Thr Gln 
1               5                   10      


<210>  10
<211>  11
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthesized

<400>  10

Ala Gln Leu Asn Thr Thr Lys Pro Thr Ser Phe 
1               5                   10      


<210>  11
<211>  11
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthesized

<400>  11

Ala Gln Leu Asn Thr Thr Lys Pro Thr Pro Ser 
1               5                   10      


<210>  12
<211>  11
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthesized

<400>  12

Met Ala Asn Asn Thr Thr Lys Pro Ile Ala Gln 
1               5                   10      


<210>  13
<211>  11
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthesized

<400>  13

Ala Gln Leu Asn Thr Thr Lys Pro Ile Ala Gln 
1               5                   10      


<210>  14
<211>  11
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthesized

<400>  14

Ala Gln Leu Asn Thr Thr Lys Pro Thr Ser Tyr 
1               5                   10      


<210>  15
<211>  11
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthesized

<400>  15

Ala Gln Leu Asn Thr Thr Lys Asn Met Thr Gln 
1               5                   10      


<210>  16
<211>  11
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthesized

<400>  16

Ala Gln Leu Asn Thr Thr Lys Pro Arg Asp Glu 
1               5                   10      


<210>  17
<211>  11
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthesized

<400>  17

Ala Gln Leu Asn Thr Thr Lys Pro Thr Ala Gln 
1               5                   10      


<210>  18
<211>  11
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthesized

<400>  18

Ala Gln Leu Asn Thr Thr Lys Asn Val Thr Gln 
1               5                   10      


<210>  19
<211>  11
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthesized

<400>  19

Gln Thr Asn Asn Thr Thr Lys Pro Ile Ala Gln 
1               5                   10      


<210>  20
<211>  11
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthesized

<400>  20

Ala Gln Leu Asn Thr Thr Lys Gln Met Asn Gln 
1               5                   10      


<210>  21
<211>  11
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthesized

<400>  21

Ala Gln Leu Asn Thr Thr Lys His Val Asp Gln 
1               5                   10      


<210>  22
<211>  11
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthesized

<400>  22

Ala Gln Leu Asn Thr Thr Lys Gln Ile Asp Gln 
1               5                   10      


<210>  23
<211>  11
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthesized

<400>  23

Val Ala Leu Asn Thr Thr Lys Pro Ile Ala Gln 
1               5                   10      


<210>  24
<211>  11
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthesized

<400>  24

Ala Met Thr Asn Thr Thr Lys Pro Ile Ala Gln 
1               5                   10      


<210>  25
<211>  11
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthesized

<400>  25

Ala Gln Leu Asn Thr Thr Lys Pro Ala Asn Gln 
1               5                   10      


<210>  26
<211>  11
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthesized

<400>  26

Ala Gln Leu Asn Thr Thr Lys Asn Val Asn Gln 
1               5                   10      


<210>  27
<211>  11
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthesized

<400>  27

Ala Gln Leu Asn Thr Thr Lys Pro Val Val Ala 
1               5                   10      


<210>  28
<211>  11
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthesized

<400>  28

Ala Gln Leu Asn Thr Thr Lys Pro Gln Asn Gln 
1               5                   10      


<210>  29
<211>  11
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthesized

<400>  29

Ala Gln Leu Asn Thr Thr Lys Pro Gln Leu Gln 
1               5                   10      


<210>  30
<211>  11
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthesized

<400>  30

Ala Gln Leu Asn Thr Thr Lys Ile Thr Asp Gln 
1               5                   10      


<210>  31
<211>  11
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthesized

<400>  31

Ala Gln Leu Asn Thr Thr Lys Leu His Asp Gln 
1               5                   10      


<210>  32
<211>  11
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthesized

<400>  32

Ala Gln Leu Asn Thr Thr Lys Asn Gly Tyr Gln 
1               5                   10      


<210>  33
<211>  11
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthesized

<400>  33

Ala Asn Val Asn Thr Thr Lys Pro Ile Ala Gln 
1               5                   10      


<210>  34
<211>  11
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthesized

<400>  34

Glu Gln Met Asn Thr Thr Lys Pro Ile Ala Gln 
1               5                   10      


<210>  35
<211>  11
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthesized

<400>  35

Ala Gln Leu Asn Thr Thr Lys Pro Leu Gln Phe 
1               5                   10      


<210>  36
<211>  11
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthesized

<400>  36

Ala Gln Leu Asn Thr Thr Lys Pro Ser Ser Gly 
1               5                   10      


<210>  37
<211>  11
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthesized

<400>  37

Ala Gln Leu Asn Thr Thr Lys Pro Val Met Gln 
1               5                   10      


<210>  38
<211>  11
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthesized

<400>  38

Ala Gln Leu Asn Thr Thr Lys Pro Leu Ala Gln 
1               5                   10      


<210>  39
<211>  11
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthesized

<400>  39

Thr Ile Thr Asn Thr Thr Lys Pro Ile Ala Gln 
1               5                   10      


<210>  40
<211>  11
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthesized

<400>  40

Ala Gln Leu Asn Thr Thr Lys Ser Phe Gly Gln 
1               5                   10      


<210>  41
<211>  7
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthesized

<400>  41

Leu Asn Thr Thr Lys Ser Val 
1               5           


<210>  42
<211>  7
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthesized

<400>  42

Leu Asn Thr Thr Lys Pro Thr 
1               5           


<210>  43
<211>  7
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthesized

<400>  43

Leu Asn Thr Thr Lys Pro Ser 
1               5           


<210>  44
<211>  7
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthesized

<400>  44

Leu Asn Thr Thr Lys Pro Val 
1               5           


<210>  45
<211>  7
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthesized

<400>  45

Leu Asn Thr Thr Lys Asn Ile 
1               5           


<210>  46
<211>  7
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthesized

<400>  46

Asn Asn Thr Thr Lys Pro Ile 
1               5           


<210>  47
<211>  7
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthesized

<400>  47

Leu Asn Thr Thr Lys Pro Ile 
1               5           


<210>  48
<211>  7
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthesized

<400>  48

Leu Asn Thr Thr Lys Asn Met 
1               5           


<210>  49
<211>  7
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthesized

<400>  49

Leu Asn Thr Thr Lys Pro Arg 
1               5           


<210>  50
<211>  7
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthesized

<400>  50

Leu Asn Thr Thr Lys Asn Val 
1               5           


<210>  51
<211>  7
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthesized

<400>  51

Leu Asn Thr Thr Lys Gln Met 
1               5           


<210>  52
<211>  7
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthesized

<400>  52

Leu Asn Thr Thr Lys Pro Gln 
1               5           


<210>  53
<211>  7
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthesized

<400>  53

Leu Asn Thr Thr Lys Ile Thr 
1               5           


<210>  54
<211>  7
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthesized

<400>  54

Leu Asn Thr Thr Lys Leu His 
1               5           


<210>  55
<211>  7
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthesized

<400>  55

Leu Asn Thr Thr Lys Asn Gly 
1               5           


<210>  56
<211>  7
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthesized

<400>  56

Val Asn Thr Thr Lys Pro Ile 
1               5           


<210>  57
<211>  7
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthesized

<400>  57

Met Asn Thr Thr Lys Pro Ile 
1               5           


<210>  58
<211>  7
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthesized

<400>  58

Leu Asn Thr Thr Lys Pro Leu 
1               5           


<210>  59
<211>  7
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthesized

<400>  59

Thr Asn Thr Thr Lys Pro Ile 
1               5           


<210>  60
<211>  7
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthesized

<400>  60

Leu Asn Thr Thr Lys Ser Phe 
1               5           


<210>  61
<211>  743
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthesized

<400>  61

Met Ala Ala Asp Gly Tyr Leu Pro Asp Trp Leu Glu Asp Asn Leu Ser 
1               5                   10                  15      


Glu Gly Ile Arg Glu Trp Trp Ala Leu Lys Pro Gly Ala Pro Gln Pro 
            20                  25                  30          


Lys Ala Asn Gln Gln His Gln Asp Asn Ala Arg Gly Leu Val Leu Pro 
        35                  40                  45              


Gly Tyr Lys Tyr Leu Gly Pro Gly Asn Gly Leu Asp Lys Gly Glu Pro 
    50                  55                  60                  


Val Asn Ala Ala Asp Ala Ala Ala Leu Glu His Asp Lys Ala Tyr Asp 
65                  70                  75                  80  


Gln Gln Leu Lys Ala Gly Asp Asn Pro Tyr Leu Lys Tyr Asn His Ala 
                85                  90                  95      


Asp Ala Glu Phe Gln Glu Arg Leu Lys Glu Asp Thr Ser Phe Gly Gly 
            100                 105                 110         


Asn Leu Gly Arg Ala Val Phe Gln Ala Lys Lys Arg Leu Leu Glu Pro 
        115                 120                 125             


Leu Gly Leu Val Glu Glu Ala Ala Lys Thr Ala Pro Gly Lys Lys Arg 
    130                 135                 140                 


Pro Val Glu Gln Ser Pro Gln Glu Pro Asp Ser Ser Ala Gly Ile Gly 
145                 150                 155                 160 


Lys Ser Gly Ala Gln Pro Ala Lys Lys Arg Leu Asn Phe Gly Gln Thr 
                165                 170                 175     


Gly Asp Thr Glu Ser Val Pro Asp Pro Gln Pro Ile Gly Glu Pro Pro 
            180                 185                 190         


Ala Ala Pro Ser Gly Val Gly Ser Leu Thr Met Ala Ser Gly Gly Gly 
        195                 200                 205             


Ala Pro Val Ala Asp Asn Asn Glu Gly Ala Asp Gly Val Gly Ser Ser 
    210                 215                 220                 


Ser Gly Asn Trp His Cys Asp Ser Gln Trp Leu Gly Asp Arg Val Ile 
225                 230                 235                 240 


Thr Thr Ser Thr Arg Thr Trp Ala Leu Pro Thr Tyr Asn Asn His Leu 
                245                 250                 255     


Tyr Lys Gln Ile Ser Asn Ser Thr Ser Gly Gly Ser Ser Asn Asp Asn 
            260                 265                 270         


Ala Tyr Phe Gly Tyr Ser Thr Pro Trp Gly Tyr Phe Asp Phe Asn Arg 
        275                 280                 285             


Phe His Cys His Phe Ser Pro Arg Asp Trp Gln Arg Leu Ile Asn Asn 
    290                 295                 300                 


Asn Trp Gly Phe Arg Pro Lys Arg Leu Asn Phe Lys Leu Phe Asn Ile 
305                 310                 315                 320 


Gln Val Lys Glu Val Thr Asp Asn Asn Gly Val Lys Thr Ile Ala Asn 
                325                 330                 335     


Asn Leu Thr Ser Thr Val Gln Val Phe Thr Asp Ser Asp Tyr Gln Leu 
            340                 345                 350         


Pro Tyr Val Leu Gly Ser Ala His Glu Gly Cys Leu Pro Pro Phe Pro 
        355                 360                 365             


Ala Asp Val Phe Met Ile Pro Gln Tyr Gly Tyr Leu Thr Leu Asn Asp 
    370                 375                 380                 


Gly Ser Gln Ala Val Gly Arg Ser Ser Phe Tyr Cys Leu Glu Tyr Phe 
385                 390                 395                 400 


Pro Ser Gln Met Leu Arg Thr Gly Asn Asn Phe Gln Phe Ser Tyr Glu 
                405                 410                 415     


Phe Glu Asn Val Pro Phe His Ser Ser Tyr Ala His Ser Gln Ser Leu 
            420                 425                 430         


Asp Arg Leu Met Asn Pro Leu Ile Asp Gln Tyr Leu Tyr Tyr Leu Ser 
        435                 440                 445             


Arg Thr Ile Asn Gly Ser Gly Gln Asn Gln Gln Thr Leu Lys Phe Ser 
    450                 455                 460                 


Val Ala Gly Pro Ser Asn Met Ala Val Gln Gly Arg Asn Tyr Ile Pro 
465                 470                 475                 480 


Gly Pro Ser Tyr Arg Gln Gln Arg Val Ser Thr Thr Val Thr Gln Asn 
                485                 490                 495     


Asn Asn Ser Glu Phe Ala Trp Pro Gly Ala Ser Ser Trp Ala Leu Asn 
            500                 505                 510         


Gly Arg Asn Ser Leu Met Asn Pro Gly Pro Ala Met Ala Ser His Lys 
        515                 520                 525             


Glu Gly Glu Asp Arg Phe Phe Pro Leu Ser Gly Ser Leu Ile Phe Gly 
    530                 535                 540                 


Lys Gln Gly Thr Gly Arg Asp Asn Val Asp Ala Asp Lys Val Met Ile 
545                 550                 555                 560 


Thr Asn Glu Glu Glu Ile Lys Thr Thr Asn Pro Val Ala Thr Glu Ser 
                565                 570                 575     


Tyr Gly Gln Val Ala Thr Asn His Gln Ser Asp Gly Thr Leu Ala Val 
            580                 585                 590         


Pro Phe Lys Ala Gln Ala Gln Thr Gly Trp Val Gln Asn Gln Gly Ile 
        595                 600                 605             


Leu Pro Gly Met Val Trp Gln Asp Arg Asp Val Tyr Leu Gln Gly Pro 
    610                 615                 620                 


Ile Trp Ala Lys Ile Pro His Thr Asp Gly Asn Phe His Pro Ser Pro 
625                 630                 635                 640 


Leu Met Gly Gly Phe Gly Met Lys His Pro Pro Pro Gln Ile Leu Ile 
                645                 650                 655     


Lys Asn Thr Pro Val Pro Ala Asp Pro Pro Thr Ala Phe Asn Lys Asp 
            660                 665                 670         


Lys Leu Asn Ser Phe Ile Thr Gln Tyr Ser Thr Gly Gln Val Ser Val 
        675                 680                 685             


Glu Ile Glu Trp Glu Leu Gln Lys Glu Asn Ser Lys Arg Trp Asn Pro 
    690                 695                 700                 


Glu Ile Gln Tyr Thr Ser Asn Tyr Tyr Lys Ser Asn Asn Val Glu Phe 
705                 710                 715                 720 


Ala Val Asn Thr Glu Gly Val Tyr Ser Glu Pro Arg Pro Ile Gly Thr 
                725                 730                 735     


Arg Tyr Leu Thr Arg Asn Leu 
            740             


<210>  62
<211>  736
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthesized

<400>  62

Met Ala Ala Asp Gly Tyr Leu Pro Asp Trp Leu Glu Asp Asn Leu Ser 
1               5                   10                  15      


Glu Gly Ile Arg Glu Trp Trp Ala Leu Lys Pro Gly Ala Pro Gln Pro 
            20                  25                  30          


Lys Ala Asn Gln Gln His Gln Asp Asn Ala Arg Gly Leu Val Leu Pro 
        35                  40                  45              


Gly Tyr Lys Tyr Leu Gly Pro Gly Asn Gly Leu Asp Lys Gly Glu Pro 
    50                  55                  60                  


Val Asn Ala Ala Asp Ala Ala Ala Leu Glu His Asp Lys Ala Tyr Asp 
65                  70                  75                  80  


Gln Gln Leu Lys Ala Gly Asp Asn Pro Tyr Leu Lys Tyr Asn His Ala 
                85                  90                  95      


Asp Ala Glu Phe Gln Glu Arg Leu Lys Glu Asp Thr Ser Phe Gly Gly 
            100                 105                 110         


Asn Leu Gly Arg Ala Val Phe Gln Ala Lys Lys Arg Leu Leu Glu Pro 
        115                 120                 125             


Leu Gly Leu Val Glu Glu Ala Ala Lys Thr Ala Pro Gly Lys Lys Arg 
    130                 135                 140                 


Pro Val Glu Gln Ser Pro Gln Glu Pro Asp Ser Ser Ala Gly Ile Gly 
145                 150                 155                 160 


Lys Ser Gly Ala Gln Pro Ala Lys Lys Arg Leu Asn Phe Gly Gln Thr 
                165                 170                 175     


Gly Asp Thr Glu Ser Val Pro Asp Pro Gln Pro Ile Gly Glu Pro Pro 
            180                 185                 190         


Ala Ala Pro Ser Gly Val Gly Ser Leu Thr Met Ala Ser Gly Gly Gly 
        195                 200                 205             


Ala Pro Val Ala Asp Asn Asn Glu Gly Ala Asp Gly Val Gly Ser Ser 
    210                 215                 220                 


Ser Gly Asn Trp His Cys Asp Ser Gln Trp Leu Gly Asp Arg Val Ile 
225                 230                 235                 240 


Thr Thr Ser Thr Arg Thr Trp Ala Leu Pro Thr Tyr Asn Asn His Leu 
                245                 250                 255     


Tyr Lys Gln Ile Ser Asn Ser Thr Ser Gly Gly Ser Ser Asn Asp Asn 
            260                 265                 270         


Ala Tyr Phe Gly Tyr Ser Thr Pro Trp Gly Tyr Phe Asp Phe Asn Arg 
        275                 280                 285             


Phe His Cys His Phe Ser Pro Arg Asp Trp Gln Arg Leu Ile Asn Asn 
    290                 295                 300                 


Asn Trp Gly Phe Arg Pro Lys Arg Leu Asn Phe Lys Leu Phe Asn Ile 
305                 310                 315                 320 


Gln Val Lys Glu Val Thr Asp Asn Asn Gly Val Lys Thr Ile Ala Asn 
                325                 330                 335     


Asn Leu Thr Ser Thr Val Gln Val Phe Thr Asp Ser Asp Tyr Gln Leu 
            340                 345                 350         


Pro Tyr Val Leu Gly Ser Ala His Glu Gly Cys Leu Pro Pro Phe Pro 
        355                 360                 365             


Ala Asp Val Phe Met Ile Pro Gln Tyr Gly Tyr Leu Thr Leu Asn Asp 
    370                 375                 380                 


Gly Ser Gln Ala Val Gly Arg Ser Ser Phe Tyr Cys Leu Glu Tyr Phe 
385                 390                 395                 400 


Pro Ser Gln Met Leu Arg Thr Gly Asn Asn Phe Gln Phe Ser Tyr Glu 
                405                 410                 415     


Phe Glu Asn Val Pro Phe His Ser Ser Tyr Ala His Ser Gln Ser Leu 
            420                 425                 430         


Asp Arg Leu Met Asn Pro Leu Ile Asp Gln Tyr Leu Tyr Tyr Leu Ser 
        435                 440                 445             


Arg Thr Ile Lys Asp Asn Thr Pro Gly Arg Gln Thr Leu Lys Phe Ser 
    450                 455                 460                 


Val Ala Gly Pro Ser Asn Met Ala Val Gln Gly Arg Asn Tyr Ile Pro 
465                 470                 475                 480 


Gly Pro Ser Tyr Arg Gln Gln Arg Val Ser Thr Thr Val Thr Gln Asn 
                485                 490                 495     


Asn Asn Ser Glu Phe Ala Trp Pro Gly Ala Ser Ser Trp Ala Leu Asn 
            500                 505                 510         


Gly Arg Asn Ser Leu Met Asn Pro Gly Pro Ala Met Ala Ser His Lys 
        515                 520                 525             


Glu Gly Glu Asp Arg Phe Phe Pro Leu Ser Gly Ser Leu Ile Phe Gly 
    530                 535                 540                 


Lys Gln Gly Thr Gly Arg Asp Asn Val Asp Ala Asp Lys Val Met Ile 
545                 550                 555                 560 


Thr Asn Glu Glu Glu Ile Lys Thr Thr Asn Pro Val Ala Thr Glu Ser 
                565                 570                 575     


Tyr Gly Gln Val Ala Thr Asn His Gln Ser Ala Gln Ala Gln Ala Gln 
            580                 585                 590         


Thr Gly Trp Val Gln Asn Gln Gly Ile Leu Pro Gly Met Val Trp Gln 
        595                 600                 605             


Asp Arg Asp Val Tyr Leu Gln Gly Pro Ile Trp Ala Lys Ile Pro His 
    610                 615                 620                 


Thr Asp Gly Asn Phe His Pro Ser Pro Leu Met Gly Gly Phe Gly Met 
625                 630                 635                 640 


Lys His Pro Pro Pro Gln Ile Leu Ile Lys Asn Thr Pro Val Pro Ala 
                645                 650                 655     


Asp Pro Pro Thr Ala Phe Asn Lys Asp Lys Leu Asn Ser Phe Ile Thr 
            660                 665                 670         


Gln Tyr Ser Thr Gly Gln Val Ser Val Glu Ile Glu Trp Glu Leu Gln 
        675                 680                 685             


Lys Glu Asn Ser Lys Arg Trp Asn Pro Glu Ile Gln Tyr Thr Ser Asn 
    690                 695                 700                 


Tyr Tyr Lys Ser Asn Asn Val Glu Phe Ala Val Asn Thr Glu Gly Val 
705                 710                 715                 720 


Tyr Ser Glu Pro Arg Pro Ile Gly Thr Arg Tyr Leu Thr Arg Asn Leu 
                725                 730                 735     


<210>  63
<211>  743
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthesized

<400>  63

Met Ala Ala Asp Gly Tyr Leu Pro Asp Trp Leu Glu Asp Asn Leu Ser 
1               5                   10                  15      


Glu Gly Ile Arg Glu Trp Trp Ala Leu Lys Pro Gly Ala Pro Gln Pro 
            20                  25                  30          


Lys Ala Asn Gln Gln His Gln Asp Asn Ala Arg Gly Leu Val Leu Pro 
        35                  40                  45              


Gly Tyr Lys Tyr Leu Gly Pro Gly Asn Gly Leu Asp Lys Gly Glu Pro 
    50                  55                  60                  


Val Asn Ala Ala Asp Ala Ala Ala Leu Glu His Asp Lys Ala Tyr Asp 
65                  70                  75                  80  


Gln Gln Leu Lys Ala Gly Asp Asn Pro Tyr Leu Lys Tyr Asn His Ala 
                85                  90                  95      


Asp Ala Glu Phe Gln Glu Arg Leu Lys Glu Asp Thr Ser Phe Gly Gly 
            100                 105                 110         


Asn Leu Gly Arg Ala Val Phe Gln Ala Lys Lys Arg Leu Leu Glu Pro 
        115                 120                 125             


Leu Gly Leu Val Glu Glu Ala Ala Lys Thr Ala Pro Gly Lys Lys Arg 
    130                 135                 140                 


Pro Val Glu Gln Ser Pro Gln Glu Pro Asp Ser Ser Ala Gly Ile Gly 
145                 150                 155                 160 


Lys Ser Gly Ala Gln Pro Ala Lys Lys Arg Leu Asn Phe Gly Gln Thr 
                165                 170                 175     


Gly Asp Thr Glu Ser Val Pro Asp Pro Gln Pro Ile Gly Glu Pro Pro 
            180                 185                 190         


Ala Ala Pro Ser Gly Val Gly Ser Leu Thr Met Ala Ser Gly Gly Gly 
        195                 200                 205             


Ala Pro Val Ala Asp Asn Asn Glu Gly Ala Asp Gly Val Gly Ser Ser 
    210                 215                 220                 


Ser Gly Asn Trp His Cys Asp Ser Gln Trp Leu Gly Asp Arg Val Ile 
225                 230                 235                 240 


Thr Thr Ser Thr Arg Thr Trp Ala Leu Pro Thr Tyr Asn Asn His Leu 
                245                 250                 255     


Tyr Lys Gln Ile Ser Asn Ser Thr Ser Gly Gly Ser Ser Asn Asp Asn 
            260                 265                 270         


Ala Tyr Phe Gly Tyr Ser Thr Pro Trp Gly Tyr Phe Asp Phe Asn Arg 
        275                 280                 285             


Phe His Cys His Phe Ser Pro Arg Asp Trp Gln Arg Leu Ile Asn Asn 
    290                 295                 300                 


Asn Trp Gly Phe Arg Pro Lys Arg Leu Asn Phe Lys Leu Phe Asn Ile 
305                 310                 315                 320 


Gln Val Lys Glu Val Thr Asp Asn Asn Gly Val Lys Thr Ile Ala Asn 
                325                 330                 335     


Asn Leu Thr Ser Thr Val Gln Val Phe Thr Asp Ser Asp Tyr Gln Leu 
            340                 345                 350         


Pro Tyr Val Leu Gly Ser Ala His Glu Gly Cys Leu Pro Pro Phe Pro 
        355                 360                 365             


Ala Asp Val Phe Met Ile Pro Gln Tyr Gly Tyr Leu Thr Leu Asn Asp 
    370                 375                 380                 


Gly Ser Gln Ala Val Gly Arg Ser Ser Phe Tyr Cys Leu Glu Tyr Phe 
385                 390                 395                 400 


Pro Ser Gln Met Leu Arg Thr Gly Asn Asn Phe Gln Phe Ser Tyr Glu 
                405                 410                 415     


Phe Glu Asn Val Pro Phe His Ser Ser Tyr Ala His Ser Gln Ser Leu 
            420                 425                 430         


Asp Arg Leu Met Asn Pro Leu Ile Asp Gln Tyr Leu Tyr Tyr Leu Ser 
        435                 440                 445             


Arg Thr Ile Gln Gln Gly Lys Gln Ser Val Gln Thr Leu Lys Phe Ser 
    450                 455                 460                 


Val Ala Gly Pro Ser Asn Met Ala Val Gln Gly Arg Asn Tyr Ile Pro 
465                 470                 475                 480 


Gly Pro Ser Tyr Arg Gln Gln Arg Val Ser Thr Thr Val Thr Gln Asn 
                485                 490                 495     


Asn Asn Ser Glu Phe Ala Trp Pro Gly Ala Ser Ser Trp Ala Leu Asn 
            500                 505                 510         


Gly Arg Asn Ser Leu Met Asn Pro Gly Pro Ala Met Ala Ser His Lys 
        515                 520                 525             


Glu Gly Glu Asp Arg Phe Phe Pro Leu Ser Gly Ser Leu Ile Phe Gly 
    530                 535                 540                 


Lys Gln Gly Thr Gly Arg Asp Asn Val Asp Ala Asp Lys Val Met Ile 
545                 550                 555                 560 


Thr Asn Glu Glu Glu Ile Lys Thr Thr Asn Pro Val Ala Thr Glu Ser 
                565                 570                 575     


Tyr Gly Gln Val Ala Thr Asn His Gln Ser Asp Gly Thr Leu Ala Val 
            580                 585                 590         


Pro Phe Lys Ala Gln Ala Gln Thr Gly Trp Val Gln Asn Gln Gly Ile 
        595                 600                 605             


Leu Pro Gly Met Val Trp Gln Asp Arg Asp Val Tyr Leu Gln Gly Pro 
    610                 615                 620                 


Ile Trp Ala Lys Ile Pro His Thr Asp Gly Asn Phe His Pro Ser Pro 
625                 630                 635                 640 


Leu Met Gly Gly Phe Gly Met Lys His Pro Pro Pro Gln Ile Leu Ile 
                645                 650                 655     


Lys Asn Thr Pro Val Pro Ala Asp Pro Pro Thr Ala Phe Asn Lys Asp 
            660                 665                 670         


Lys Leu Asn Ser Phe Ile Thr Gln Tyr Ser Thr Gly Gln Val Ser Val 
        675                 680                 685             


Glu Ile Glu Trp Glu Leu Gln Lys Glu Asn Ser Lys Arg Trp Asn Pro 
    690                 695                 700                 


Glu Ile Gln Tyr Thr Ser Asn Tyr Tyr Lys Ser Asn Asn Val Glu Phe 
705                 710                 715                 720 


Ala Val Asn Thr Glu Gly Val Tyr Ser Glu Pro Arg Pro Ile Gly Thr 
                725                 730                 735     


Arg Tyr Leu Thr Arg Asn Leu 
            740             


<210>  64
<211>  743
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthesized

<400>  64

Met Ala Ala Asp Gly Tyr Leu Pro Asp Trp Leu Glu Asp Asn Leu Ser 
1               5                   10                  15      


Glu Gly Ile Arg Glu Trp Trp Ala Leu Lys Pro Gly Ala Pro Gln Pro 
            20                  25                  30          


Lys Ala Asn Gln Gln His Gln Asp Asn Ala Arg Gly Leu Val Leu Pro 
        35                  40                  45              


Gly Tyr Lys Tyr Leu Gly Pro Gly Asn Gly Leu Asp Lys Gly Glu Pro 
    50                  55                  60                  


Val Asn Ala Ala Asp Ala Ala Ala Leu Glu His Asp Lys Ala Tyr Asp 
65                  70                  75                  80  


Gln Gln Leu Lys Ala Gly Asp Asn Pro Tyr Leu Lys Tyr Asn His Ala 
                85                  90                  95      


Asp Ala Glu Phe Gln Glu Arg Leu Lys Glu Asp Thr Ser Phe Gly Gly 
            100                 105                 110         


Asn Leu Gly Arg Ala Val Phe Gln Ala Lys Lys Arg Leu Leu Glu Pro 
        115                 120                 125             


Leu Gly Leu Val Glu Glu Ala Ala Lys Thr Ala Pro Gly Lys Lys Arg 
    130                 135                 140                 


Pro Val Glu Gln Ser Pro Gln Glu Pro Asp Ser Ser Ala Gly Ile Gly 
145                 150                 155                 160 


Lys Ser Gly Ala Gln Pro Ala Lys Lys Arg Leu Asn Phe Gly Gln Thr 
                165                 170                 175     


Gly Asp Thr Glu Ser Val Pro Asp Pro Gln Pro Ile Gly Glu Pro Pro 
            180                 185                 190         


Ala Ala Pro Ser Gly Val Gly Ser Leu Thr Met Ala Ser Gly Gly Gly 
        195                 200                 205             


Ala Pro Val Ala Asp Asn Asn Glu Gly Ala Asp Gly Val Gly Ser Ser 
    210                 215                 220                 


Ser Gly Asn Trp His Cys Asp Ser Gln Trp Leu Gly Asp Arg Val Ile 
225                 230                 235                 240 


Thr Thr Ser Thr Arg Thr Trp Ala Leu Pro Thr Tyr Asn Asn His Leu 
                245                 250                 255     


Tyr Lys Gln Ile Ser Asn Ser Thr Ser Gly Gly Ser Ser Asn Asp Asn 
            260                 265                 270         


Ala Tyr Phe Gly Tyr Ser Thr Pro Trp Gly Tyr Phe Asp Phe Asn Arg 
        275                 280                 285             


Phe His Cys His Phe Ser Pro Arg Asp Trp Gln Arg Leu Ile Asn Asn 
    290                 295                 300                 


Asn Trp Gly Phe Arg Pro Lys Arg Leu Asn Phe Lys Leu Phe Asn Ile 
305                 310                 315                 320 


Gln Val Lys Glu Val Thr Asp Asn Asn Gly Val Lys Thr Ile Ala Asn 
                325                 330                 335     


Asn Leu Thr Ser Thr Val Gln Val Phe Thr Asp Ser Asp Tyr Gln Leu 
            340                 345                 350         


Pro Tyr Val Leu Gly Ser Ala His Glu Gly Cys Leu Pro Pro Phe Pro 
        355                 360                 365             


Ala Asp Val Phe Met Ile Pro Gln Tyr Gly Tyr Leu Thr Leu Asn Asp 
    370                 375                 380                 


Gly Ser Gln Ala Val Gly Arg Ser Ser Phe Tyr Cys Leu Glu Tyr Phe 
385                 390                 395                 400 


Pro Ser Gln Met Leu Arg Thr Gly Asn Asn Phe Gln Phe Ser Tyr Glu 
                405                 410                 415     


Phe Glu Asn Val Pro Phe His Ser Ser Tyr Ala His Ser Gln Ser Leu 
            420                 425                 430         


Asp Arg Leu Met Asn Pro Leu Ile Asp Gln Tyr Leu Tyr Tyr Leu Ser 
        435                 440                 445             


Arg Thr Ile Asp Gly Ala Ala Thr Lys Asn Gln Thr Leu Lys Phe Ser 
    450                 455                 460                 


Val Ala Gly Pro Ser Asn Met Ala Val Gln Gly Arg Asn Tyr Ile Pro 
465                 470                 475                 480 


Gly Pro Ser Tyr Arg Gln Gln Arg Val Ser Thr Thr Val Thr Gln Asn 
                485                 490                 495     


Asn Asn Ser Glu Phe Ala Trp Pro Gly Ala Ser Ser Trp Ala Leu Asn 
            500                 505                 510         


Gly Arg Asn Ser Leu Met Asn Pro Gly Pro Ala Met Ala Ser His Lys 
        515                 520                 525             


Glu Gly Glu Asp Arg Phe Phe Pro Leu Ser Gly Ser Leu Ile Phe Gly 
    530                 535                 540                 


Lys Gln Gly Thr Gly Arg Asp Asn Val Asp Ala Asp Lys Val Met Ile 
545                 550                 555                 560 


Thr Asn Glu Glu Glu Ile Lys Thr Thr Asn Pro Val Ala Thr Glu Ser 
                565                 570                 575     


Tyr Gly Gln Val Ala Thr Asn His Gln Ser Asp Gly Thr Leu Ala Val 
            580                 585                 590         


Pro Phe Lys Ala Gln Ala Gln Thr Gly Trp Val Gln Asn Gln Gly Ile 
        595                 600                 605             


Leu Pro Gly Met Val Trp Gln Asp Arg Asp Val Tyr Leu Gln Gly Pro 
    610                 615                 620                 


Ile Trp Ala Lys Ile Pro His Thr Asp Gly Asn Phe His Pro Ser Pro 
625                 630                 635                 640 


Leu Met Gly Gly Phe Gly Met Lys His Pro Pro Pro Gln Ile Leu Ile 
                645                 650                 655     


Lys Asn Thr Pro Val Pro Ala Asp Pro Pro Thr Ala Phe Asn Lys Asp 
            660                 665                 670         


Lys Leu Asn Ser Phe Ile Thr Gln Tyr Ser Thr Gly Gln Val Ser Val 
        675                 680                 685             


Glu Ile Glu Trp Glu Leu Gln Lys Glu Asn Ser Lys Arg Trp Asn Pro 
    690                 695                 700                 


Glu Ile Gln Tyr Thr Ser Asn Tyr Tyr Lys Ser Asn Asn Val Glu Phe 
705                 710                 715                 720 


Ala Val Asn Thr Glu Gly Val Tyr Ser Glu Pro Arg Pro Ile Gly Thr 
                725                 730                 735     


Arg Tyr Leu Thr Arg Asn Leu 
            740             


<210>  65
<211>  743
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthesized

<400>  65

Met Ala Ala Asp Gly Tyr Leu Pro Asp Trp Leu Glu Asp Asn Leu Ser 
1               5                   10                  15      


Glu Gly Ile Arg Glu Trp Trp Ala Leu Lys Pro Gly Ala Pro Gln Pro 
            20                  25                  30          


Lys Ala Asn Gln Gln His Gln Asp Asn Ala Arg Gly Leu Val Leu Pro 
        35                  40                  45              


Gly Tyr Lys Tyr Leu Gly Pro Gly Asn Gly Leu Asp Lys Gly Glu Pro 
    50                  55                  60                  


Val Asn Ala Ala Asp Ala Ala Ala Leu Glu His Asp Lys Ala Tyr Asp 
65                  70                  75                  80  


Gln Gln Leu Lys Ala Gly Asp Asn Pro Tyr Leu Lys Tyr Asn His Ala 
                85                  90                  95      


Asp Ala Glu Phe Gln Glu Arg Leu Lys Glu Asp Thr Ser Phe Gly Gly 
            100                 105                 110         


Asn Leu Gly Arg Ala Val Phe Gln Ala Lys Lys Arg Leu Leu Glu Pro 
        115                 120                 125             


Leu Gly Leu Val Glu Glu Ala Ala Lys Thr Ala Pro Gly Lys Lys Arg 
    130                 135                 140                 


Pro Val Glu Gln Ser Pro Gln Glu Pro Asp Ser Ser Ala Gly Ile Gly 
145                 150                 155                 160 


Lys Ser Gly Ala Gln Pro Ala Lys Lys Arg Leu Asn Phe Gly Gln Thr 
                165                 170                 175     


Gly Asp Thr Glu Ser Val Pro Asp Pro Gln Pro Ile Gly Glu Pro Pro 
            180                 185                 190         


Ala Ala Pro Ser Gly Val Gly Ser Leu Thr Met Ala Ser Gly Gly Gly 
        195                 200                 205             


Ala Pro Val Ala Asp Asn Asn Glu Gly Ala Asp Gly Val Gly Ser Ser 
    210                 215                 220                 


Ser Gly Asn Trp His Cys Asp Ser Gln Trp Leu Gly Asp Arg Val Ile 
225                 230                 235                 240 


Thr Thr Ser Thr Arg Thr Trp Ala Leu Pro Thr Tyr Asn Asn His Leu 
                245                 250                 255     


Tyr Lys Gln Ile Ser Asn Ser Thr Ser Gly Gly Ser Ser Asn Asp Asn 
            260                 265                 270         


Ala Tyr Phe Gly Tyr Ser Thr Pro Trp Gly Tyr Phe Asp Phe Asn Arg 
        275                 280                 285             


Phe His Cys His Phe Ser Pro Arg Asp Trp Gln Arg Leu Ile Asn Asn 
    290                 295                 300                 


Asn Trp Gly Phe Arg Pro Lys Arg Leu Asn Phe Lys Leu Phe Asn Ile 
305                 310                 315                 320 


Gln Val Lys Glu Val Thr Asp Asn Asn Gly Val Lys Thr Ile Ala Asn 
                325                 330                 335     


Asn Leu Thr Ser Thr Val Gln Val Phe Thr Asp Ser Asp Tyr Gln Leu 
            340                 345                 350         


Pro Tyr Val Leu Gly Ser Ala His Glu Gly Cys Leu Pro Pro Phe Pro 
        355                 360                 365             


Ala Asp Val Phe Met Ile Pro Gln Tyr Gly Tyr Leu Thr Leu Asn Asp 
    370                 375                 380                 


Gly Ser Gln Ala Val Gly Arg Ser Ser Phe Tyr Cys Leu Glu Tyr Phe 
385                 390                 395                 400 


Pro Ser Gln Met Leu Arg Thr Gly Asn Asn Phe Gln Phe Ser Tyr Glu 
                405                 410                 415     


Phe Glu Asn Val Pro Phe His Ser Ser Tyr Ala His Ser Gln Ser Leu 
            420                 425                 430         


Asp Arg Leu Met Asn Pro Leu Ile Asp Gln Tyr Leu Tyr Tyr Leu Ser 
        435                 440                 445             


Arg Thr Ile Asp Gly Gln Ser Ser Lys Ser Gln Thr Leu Lys Phe Ser 
    450                 455                 460                 


Val Ala Gly Pro Ser Asn Met Ala Val Gln Gly Arg Asn Tyr Ile Pro 
465                 470                 475                 480 


Gly Pro Ser Tyr Arg Gln Gln Arg Val Ser Thr Thr Val Thr Gln Asn 
                485                 490                 495     


Asn Asn Ser Glu Phe Ala Trp Pro Gly Ala Ser Ser Trp Ala Leu Asn 
            500                 505                 510         


Gly Arg Asn Ser Leu Met Asn Pro Gly Pro Ala Met Ala Ser His Lys 
        515                 520                 525             


Glu Gly Glu Asp Arg Phe Phe Pro Leu Ser Gly Ser Leu Ile Phe Gly 
    530                 535                 540                 


Lys Gln Gly Thr Gly Arg Asp Asn Val Asp Ala Asp Lys Val Met Ile 
545                 550                 555                 560 


Thr Asn Glu Glu Glu Ile Lys Thr Thr Asn Pro Val Ala Thr Glu Ser 
                565                 570                 575     


Tyr Gly Gln Val Ala Thr Asn His Gln Ser Asp Gly Thr Leu Ala Val 
            580                 585                 590         


Pro Phe Lys Ala Gln Ala Gln Thr Gly Trp Val Gln Asn Gln Gly Ile 
        595                 600                 605             


Leu Pro Gly Met Val Trp Gln Asp Arg Asp Val Tyr Leu Gln Gly Pro 
    610                 615                 620                 


Ile Trp Ala Lys Ile Pro His Thr Asp Gly Asn Phe His Pro Ser Pro 
625                 630                 635                 640 


Leu Met Gly Gly Phe Gly Met Lys His Pro Pro Pro Gln Ile Leu Ile 
                645                 650                 655     


Lys Asn Thr Pro Val Pro Ala Asp Pro Pro Thr Ala Phe Asn Lys Asp 
            660                 665                 670         


Lys Leu Asn Ser Phe Ile Thr Gln Tyr Ser Thr Gly Gln Val Ser Val 
        675                 680                 685             


Glu Ile Glu Trp Glu Leu Gln Lys Glu Asn Ser Lys Arg Trp Asn Pro 
    690                 695                 700                 


Glu Ile Gln Tyr Thr Ser Asn Tyr Tyr Lys Ser Asn Asn Val Glu Phe 
705                 710                 715                 720 


Ala Val Asn Thr Glu Gly Val Tyr Ser Glu Pro Arg Pro Ile Gly Thr 
                725                 730                 735     


Arg Tyr Leu Thr Arg Asn Leu 
            740             


<210>  66
<211>  743
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthesized

<400>  66

Met Ala Ala Asp Gly Tyr Leu Pro Asp Trp Leu Glu Asp Asn Leu Ser 
1               5                   10                  15      


Glu Gly Ile Arg Glu Trp Trp Ala Leu Lys Pro Gly Ala Pro Gln Pro 
            20                  25                  30          


Lys Ala Asn Gln Gln His Gln Asp Asn Ala Arg Gly Leu Val Leu Pro 
        35                  40                  45              


Gly Tyr Lys Tyr Leu Gly Pro Gly Asn Gly Leu Asp Lys Gly Glu Pro 
    50                  55                  60                  


Val Asn Ala Ala Asp Ala Ala Ala Leu Glu His Asp Lys Ala Tyr Asp 
65                  70                  75                  80  


Gln Gln Leu Lys Ala Gly Asp Asn Pro Tyr Leu Lys Tyr Asn His Ala 
                85                  90                  95      


Asp Ala Glu Phe Gln Glu Arg Leu Lys Glu Asp Thr Ser Phe Gly Gly 
            100                 105                 110         


Asn Leu Gly Arg Ala Val Phe Gln Ala Lys Lys Arg Leu Leu Glu Pro 
        115                 120                 125             


Leu Gly Leu Val Glu Glu Ala Ala Lys Thr Ala Pro Gly Lys Lys Arg 
    130                 135                 140                 


Pro Val Glu Gln Ser Pro Gln Glu Pro Asp Ser Ser Ala Gly Ile Gly 
145                 150                 155                 160 


Lys Ser Gly Ala Gln Pro Ala Lys Lys Arg Leu Asn Phe Gly Gln Thr 
                165                 170                 175     


Gly Asp Thr Glu Ser Val Pro Asp Pro Gln Pro Ile Gly Glu Pro Pro 
            180                 185                 190         


Ala Ala Pro Ser Gly Val Gly Ser Leu Thr Met Ala Ser Gly Gly Gly 
        195                 200                 205             


Ala Pro Val Ala Asp Asn Asn Glu Gly Ala Asp Gly Val Gly Ser Ser 
    210                 215                 220                 


Ser Gly Asn Trp His Cys Asp Ser Gln Trp Leu Gly Asp Arg Val Ile 
225                 230                 235                 240 


Thr Thr Ser Thr Arg Thr Trp Ala Leu Pro Thr Tyr Asn Asn His Leu 
                245                 250                 255     


Tyr Lys Gln Ile Ser Asn Ser Thr Ser Gly Gly Ser Ser Asn Asp Asn 
            260                 265                 270         


Ala Tyr Phe Gly Tyr Ser Thr Pro Trp Gly Tyr Phe Asp Phe Asn Arg 
        275                 280                 285             


Phe His Cys His Phe Ser Pro Arg Asp Trp Gln Arg Leu Ile Asn Asn 
    290                 295                 300                 


Asn Trp Gly Phe Arg Pro Lys Arg Leu Asn Phe Lys Leu Phe Asn Ile 
305                 310                 315                 320 


Gln Val Lys Glu Val Thr Asp Asn Asn Gly Val Lys Thr Ile Ala Asn 
                325                 330                 335     


Asn Leu Thr Ser Thr Val Gln Val Phe Thr Asp Ser Asp Tyr Gln Leu 
            340                 345                 350         


Pro Tyr Val Leu Gly Ser Ala His Glu Gly Cys Leu Pro Pro Phe Pro 
        355                 360                 365             


Ala Asp Val Phe Met Ile Pro Gln Tyr Gly Tyr Leu Thr Leu Asn Asp 
    370                 375                 380                 


Gly Ser Gln Ala Val Gly Arg Ser Ser Phe Tyr Cys Leu Glu Tyr Phe 
385                 390                 395                 400 


Pro Ser Gln Met Leu Arg Thr Gly Asn Asn Phe Gln Phe Ser Tyr Glu 
                405                 410                 415     


Phe Glu Asn Val Pro Phe His Ser Ser Tyr Ala His Ser Gln Ser Leu 
            420                 425                 430         


Asp Arg Leu Met Asn Pro Leu Ile Asp Gln Tyr Leu Tyr Tyr Leu Ser 
        435                 440                 445             


Arg Thr Ile Asn Gly Ser Gly Gln Asn Gln Gln Thr Leu Lys Phe Ser 
    450                 455                 460                 


Val Ala Gly Pro Ser Asn Met Ala Val Gln Gly Arg Asn Tyr Ile Pro 
465                 470                 475                 480 


Gly Pro Ser Tyr Arg Gln Gln Arg Val Ser Thr Thr Val Thr Gln Asn 
                485                 490                 495     


Asn Asn Ser Glu Phe Ala Trp Pro Gly Ala Ser Ser Trp Ala Leu Asn 
            500                 505                 510         


Gly Arg Asn Ser Leu Met Asn Pro Gly Pro Ala Met Ala Ser His Lys 
        515                 520                 525             


Glu Gly Glu Asp Arg Phe Phe Pro Leu Ser Gly Ser Leu Ile Phe Gly 
    530                 535                 540                 


Lys Gln Gly Thr Gly Arg Asp Asn Val Asp Ala Asp Lys Val Met Ile 
545                 550                 555                 560 


Thr Asn Glu Glu Glu Ile Lys Thr Thr Asn Pro Val Ala Thr Glu Ser 
                565                 570                 575     


Tyr Gly Gln Val Ala Thr Asn His Gln Ser Ala Gln Leu Asn Thr Thr 
            580                 585                 590         


Lys Pro Thr Asp Arg Ala Gln Thr Gly Trp Val Gln Asn Gln Gly Ile 
        595                 600                 605             


Leu Pro Gly Met Val Trp Gln Asp Arg Asp Val Tyr Leu Gln Gly Pro 
    610                 615                 620                 


Ile Trp Ala Lys Ile Pro His Thr Asp Gly Asn Phe His Pro Ser Pro 
625                 630                 635                 640 


Leu Met Gly Gly Phe Gly Met Lys His Pro Pro Pro Gln Ile Leu Ile 
                645                 650                 655     


Lys Asn Thr Pro Val Pro Ala Asp Pro Pro Thr Ala Phe Asn Lys Asp 
            660                 665                 670         


Lys Leu Asn Ser Phe Ile Thr Gln Tyr Ser Thr Gly Gln Val Ser Val 
        675                 680                 685             


Glu Ile Glu Trp Glu Leu Gln Lys Glu Asn Ser Lys Arg Trp Asn Pro 
    690                 695                 700                 


Glu Ile Gln Tyr Thr Ser Asn Tyr Tyr Lys Ser Asn Asn Val Glu Phe 
705                 710                 715                 720 


Ala Val Asn Thr Glu Gly Val Tyr Ser Glu Pro Arg Pro Ile Gly Thr 
                725                 730                 735     


Arg Tyr Leu Thr Arg Asn Leu 
            740             


<210>  67
<211>  743
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthesized

<400>  67

Met Ala Ala Asp Gly Tyr Leu Pro Asp Trp Leu Glu Asp Asn Leu Ser 
1               5                   10                  15      


Glu Gly Ile Arg Glu Trp Trp Ala Leu Lys Pro Gly Ala Pro Gln Pro 
            20                  25                  30          


Lys Ala Asn Gln Gln His Gln Asp Asn Ala Arg Gly Leu Val Leu Pro 
        35                  40                  45              


Gly Tyr Lys Tyr Leu Gly Pro Gly Asn Gly Leu Asp Lys Gly Glu Pro 
    50                  55                  60                  


Val Asn Ala Ala Asp Ala Ala Ala Leu Glu His Asp Lys Ala Tyr Asp 
65                  70                  75                  80  


Gln Gln Leu Lys Ala Gly Asp Asn Pro Tyr Leu Lys Tyr Asn His Ala 
                85                  90                  95      


Asp Ala Glu Phe Gln Glu Arg Leu Lys Glu Asp Thr Ser Phe Gly Gly 
            100                 105                 110         


Asn Leu Gly Arg Ala Val Phe Gln Ala Lys Lys Arg Leu Leu Glu Pro 
        115                 120                 125             


Leu Gly Leu Val Glu Glu Ala Ala Lys Thr Ala Pro Gly Lys Lys Arg 
    130                 135                 140                 


Pro Val Glu Gln Ser Pro Gln Glu Pro Asp Ser Ser Ala Gly Ile Gly 
145                 150                 155                 160 


Lys Ser Gly Ala Gln Pro Ala Lys Lys Arg Leu Asn Phe Gly Gln Thr 
                165                 170                 175     


Gly Asp Thr Glu Ser Val Pro Asp Pro Gln Pro Ile Gly Glu Pro Pro 
            180                 185                 190         


Ala Ala Pro Ser Gly Val Gly Ser Leu Thr Met Ala Ser Gly Gly Gly 
        195                 200                 205             


Ala Pro Val Ala Asp Asn Asn Glu Gly Ala Asp Gly Val Gly Ser Ser 
    210                 215                 220                 


Ser Gly Asn Trp His Cys Asp Ser Gln Trp Leu Gly Asp Arg Val Ile 
225                 230                 235                 240 


Thr Thr Ser Thr Arg Thr Trp Ala Leu Pro Thr Tyr Asn Asn His Leu 
                245                 250                 255     


Tyr Lys Gln Ile Ser Asn Ser Thr Ser Gly Gly Ser Ser Asn Asp Asn 
            260                 265                 270         


Ala Tyr Phe Gly Tyr Ser Thr Pro Trp Gly Tyr Phe Asp Phe Asn Arg 
        275                 280                 285             


Phe His Cys His Phe Ser Pro Arg Asp Trp Gln Arg Leu Ile Asn Asn 
    290                 295                 300                 


Asn Trp Gly Phe Arg Pro Lys Arg Leu Asn Phe Lys Leu Phe Asn Ile 
305                 310                 315                 320 


Gln Val Lys Glu Val Thr Asp Asn Asn Gly Val Lys Thr Ile Ala Asn 
                325                 330                 335     


Asn Leu Thr Ser Thr Val Gln Val Phe Thr Asp Ser Asp Tyr Gln Leu 
            340                 345                 350         


Pro Tyr Val Leu Gly Ser Ala His Glu Gly Cys Leu Pro Pro Phe Pro 
        355                 360                 365             


Ala Asp Val Phe Met Ile Pro Gln Tyr Gly Tyr Leu Thr Leu Asn Asp 
    370                 375                 380                 


Gly Ser Gln Ala Val Gly Arg Ser Ser Phe Tyr Cys Leu Glu Tyr Phe 
385                 390                 395                 400 


Pro Ser Gln Met Leu Arg Thr Gly Asn Asn Phe Gln Phe Ser Tyr Glu 
                405                 410                 415     


Phe Glu Asn Val Pro Phe His Ser Ser Tyr Ala His Ser Gln Ser Leu 
            420                 425                 430         


Asp Arg Leu Met Asn Pro Leu Ile Asp Gln Tyr Leu Tyr Tyr Leu Ser 
        435                 440                 445             


Arg Thr Ile Asn Gly Ser Gly Gln Asn Gln Gln Thr Leu Lys Phe Ser 
    450                 455                 460                 


Val Ala Gly Pro Ser Asn Met Ala Val Gln Gly Arg Asn Tyr Ile Pro 
465                 470                 475                 480 


Gly Pro Ser Tyr Arg Gln Gln Arg Val Ser Thr Thr Val Thr Gln Asn 
                485                 490                 495     


Asn Asn Ser Glu Phe Ala Trp Pro Gly Ala Ser Ser Trp Ala Leu Asn 
            500                 505                 510         


Gly Arg Asn Ser Leu Met Asn Pro Gly Pro Ala Met Ala Ser His Lys 
        515                 520                 525             


Glu Gly Glu Asp Arg Phe Phe Pro Leu Ser Gly Ser Leu Ile Phe Gly 
    530                 535                 540                 


Lys Gln Gly Thr Gly Arg Asp Asn Val Asp Ala Asp Lys Val Met Ile 
545                 550                 555                 560 


Thr Asn Glu Glu Glu Ile Lys Thr Thr Asn Pro Val Ala Thr Glu Ser 
                565                 570                 575     


Tyr Gly Gln Val Ala Thr Asn His Gln Ser Ala Gln Leu Asn Thr Thr 
            580                 585                 590         


Lys Pro Thr Gly Pro Ala Gln Thr Gly Trp Val Gln Asn Gln Gly Ile 
        595                 600                 605             


Leu Pro Gly Met Val Trp Gln Asp Arg Asp Val Tyr Leu Gln Gly Pro 
    610                 615                 620                 


Ile Trp Ala Lys Ile Pro His Thr Asp Gly Asn Phe His Pro Ser Pro 
625                 630                 635                 640 


Leu Met Gly Gly Phe Gly Met Lys His Pro Pro Pro Gln Ile Leu Ile 
                645                 650                 655     


Lys Asn Thr Pro Val Pro Ala Asp Pro Pro Thr Ala Phe Asn Lys Asp 
            660                 665                 670         


Lys Leu Asn Ser Phe Ile Thr Gln Tyr Ser Thr Gly Gln Val Ser Val 
        675                 680                 685             


Glu Ile Glu Trp Glu Leu Gln Lys Glu Asn Ser Lys Arg Trp Asn Pro 
    690                 695                 700                 


Glu Ile Gln Tyr Thr Ser Asn Tyr Tyr Lys Ser Asn Asn Val Glu Phe 
705                 710                 715                 720 


Ala Val Asn Thr Glu Gly Val Tyr Ser Glu Pro Arg Pro Ile Gly Thr 
                725                 730                 735     


Arg Tyr Leu Thr Arg Asn Leu 
            740             


<210>  68
<211>  743
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthesized

<400>  68

Met Ala Ala Asp Gly Tyr Leu Pro Asp Trp Leu Glu Asp Asn Leu Ser 
1               5                   10                  15      


Glu Gly Ile Arg Glu Trp Trp Ala Leu Lys Pro Gly Ala Pro Gln Pro 
            20                  25                  30          


Lys Ala Asn Gln Gln His Gln Asp Asn Ala Arg Gly Leu Val Leu Pro 
        35                  40                  45              


Gly Tyr Lys Tyr Leu Gly Pro Gly Asn Gly Leu Asp Lys Gly Glu Pro 
    50                  55                  60                  


Val Asn Ala Ala Asp Ala Ala Ala Leu Glu His Asp Lys Ala Tyr Asp 
65                  70                  75                  80  


Gln Gln Leu Lys Ala Gly Asp Asn Pro Tyr Leu Lys Tyr Asn His Ala 
                85                  90                  95      


Asp Ala Glu Phe Gln Glu Arg Leu Lys Glu Asp Thr Ser Phe Gly Gly 
            100                 105                 110         


Asn Leu Gly Arg Ala Val Phe Gln Ala Lys Lys Arg Leu Leu Glu Pro 
        115                 120                 125             


Leu Gly Leu Val Glu Glu Ala Ala Lys Thr Ala Pro Gly Lys Lys Arg 
    130                 135                 140                 


Pro Val Glu Gln Ser Pro Gln Glu Pro Asp Ser Ser Ala Gly Ile Gly 
145                 150                 155                 160 


Lys Ser Gly Ala Gln Pro Ala Lys Lys Arg Leu Asn Phe Gly Gln Thr 
                165                 170                 175     


Gly Asp Thr Glu Ser Val Pro Asp Pro Gln Pro Ile Gly Glu Pro Pro 
            180                 185                 190         


Ala Ala Pro Ser Gly Val Gly Ser Leu Thr Met Ala Ser Gly Gly Gly 
        195                 200                 205             


Ala Pro Val Ala Asp Asn Asn Glu Gly Ala Asp Gly Val Gly Ser Ser 
    210                 215                 220                 


Ser Gly Asn Trp His Cys Asp Ser Gln Trp Leu Gly Asp Arg Val Ile 
225                 230                 235                 240 


Thr Thr Ser Thr Arg Thr Trp Ala Leu Pro Thr Tyr Asn Asn His Leu 
                245                 250                 255     


Tyr Lys Gln Ile Ser Asn Ser Thr Ser Gly Gly Ser Ser Asn Asp Asn 
            260                 265                 270         


Ala Tyr Phe Gly Tyr Ser Thr Pro Trp Gly Tyr Phe Asp Phe Asn Arg 
        275                 280                 285             


Phe His Cys His Phe Ser Pro Arg Asp Trp Gln Arg Leu Ile Asn Asn 
    290                 295                 300                 


Asn Trp Gly Phe Arg Pro Lys Arg Leu Asn Phe Lys Leu Phe Asn Ile 
305                 310                 315                 320 


Gln Val Lys Glu Val Thr Asp Asn Asn Gly Val Lys Thr Ile Ala Asn 
                325                 330                 335     


Asn Leu Thr Ser Thr Val Gln Val Phe Thr Asp Ser Asp Tyr Gln Leu 
            340                 345                 350         


Pro Tyr Val Leu Gly Ser Ala His Glu Gly Cys Leu Pro Pro Phe Pro 
        355                 360                 365             


Ala Asp Val Phe Met Ile Pro Gln Tyr Gly Tyr Leu Thr Leu Asn Asp 
    370                 375                 380                 


Gly Ser Gln Ala Val Gly Arg Ser Ser Phe Tyr Cys Leu Glu Tyr Phe 
385                 390                 395                 400 


Pro Ser Gln Met Leu Arg Thr Gly Asn Asn Phe Gln Phe Ser Tyr Glu 
                405                 410                 415     


Phe Glu Asn Val Pro Phe His Ser Ser Tyr Ala His Ser Gln Ser Leu 
            420                 425                 430         


Asp Arg Leu Met Asn Pro Leu Ile Asp Gln Tyr Leu Tyr Tyr Leu Ser 
        435                 440                 445             


Arg Thr Ile Asn Gly Ser Gly Gln Asn Gln Gln Thr Leu Lys Phe Ser 
    450                 455                 460                 


Val Ala Gly Pro Ser Asn Met Ala Val Gln Gly Arg Asn Tyr Ile Pro 
465                 470                 475                 480 


Gly Pro Ser Tyr Arg Gln Gln Arg Val Ser Thr Thr Val Thr Gln Asn 
                485                 490                 495     


Asn Asn Ser Glu Phe Ala Trp Pro Gly Ala Ser Ser Trp Ala Leu Asn 
            500                 505                 510         


Gly Arg Asn Ser Leu Met Asn Pro Gly Pro Ala Met Ala Ser His Lys 
        515                 520                 525             


Glu Gly Glu Asp Arg Phe Phe Pro Leu Ser Gly Ser Leu Ile Phe Gly 
    530                 535                 540                 


Lys Gln Gly Thr Gly Arg Asp Asn Val Asp Ala Asp Lys Val Met Ile 
545                 550                 555                 560 


Thr Asn Glu Glu Glu Ile Lys Thr Thr Asn Pro Val Ala Thr Glu Ser 
                565                 570                 575     


Tyr Gly Gln Val Ala Thr Asn His Gln Ser Ala Gln Leu Asn Thr Thr 
            580                 585                 590         


Lys Pro Ser Pro Gly Ala Gln Thr Gly Trp Val Gln Asn Gln Gly Ile 
        595                 600                 605             


Leu Pro Gly Met Val Trp Gln Asp Arg Asp Val Tyr Leu Gln Gly Pro 
    610                 615                 620                 


Ile Trp Ala Lys Ile Pro His Thr Asp Gly Asn Phe His Pro Ser Pro 
625                 630                 635                 640 


Leu Met Gly Gly Phe Gly Met Lys His Pro Pro Pro Gln Ile Leu Ile 
                645                 650                 655     


Lys Asn Thr Pro Val Pro Ala Asp Pro Pro Thr Ala Phe Asn Lys Asp 
            660                 665                 670         


Lys Leu Asn Ser Phe Ile Thr Gln Tyr Ser Thr Gly Gln Val Ser Val 
        675                 680                 685             


Glu Ile Glu Trp Glu Leu Gln Lys Glu Asn Ser Lys Arg Trp Asn Pro 
    690                 695                 700                 


Glu Ile Gln Tyr Thr Ser Asn Tyr Tyr Lys Ser Asn Asn Val Glu Phe 
705                 710                 715                 720 


Ala Val Asn Thr Glu Gly Val Tyr Ser Glu Pro Arg Pro Ile Gly Thr 
                725                 730                 735     


Arg Tyr Leu Thr Arg Asn Leu 
            740             


<210>  69
<211>  743
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthesized

<400>  69

Met Ala Ala Asp Gly Tyr Leu Pro Asp Trp Leu Glu Asp Asn Leu Ser 
1               5                   10                  15      


Glu Gly Ile Arg Glu Trp Trp Ala Leu Lys Pro Gly Ala Pro Gln Pro 
            20                  25                  30          


Lys Ala Asn Gln Gln His Gln Asp Asn Ala Arg Gly Leu Val Leu Pro 
        35                  40                  45              


Gly Tyr Lys Tyr Leu Gly Pro Gly Asn Gly Leu Asp Lys Gly Glu Pro 
    50                  55                  60                  


Val Asn Ala Ala Asp Ala Ala Ala Leu Glu His Asp Lys Ala Tyr Asp 
65                  70                  75                  80  


Gln Gln Leu Lys Ala Gly Asp Asn Pro Tyr Leu Lys Tyr Asn His Ala 
                85                  90                  95      


Asp Ala Glu Phe Gln Glu Arg Leu Lys Glu Asp Thr Ser Phe Gly Gly 
            100                 105                 110         


Asn Leu Gly Arg Ala Val Phe Gln Ala Lys Lys Arg Leu Leu Glu Pro 
        115                 120                 125             


Leu Gly Leu Val Glu Glu Ala Ala Lys Thr Ala Pro Gly Lys Lys Arg 
    130                 135                 140                 


Pro Val Glu Gln Ser Pro Gln Glu Pro Asp Ser Ser Ala Gly Ile Gly 
145                 150                 155                 160 


Lys Ser Gly Ala Gln Pro Ala Lys Lys Arg Leu Asn Phe Gly Gln Thr 
                165                 170                 175     


Gly Asp Thr Glu Ser Val Pro Asp Pro Gln Pro Ile Gly Glu Pro Pro 
            180                 185                 190         


Ala Ala Pro Ser Gly Val Gly Ser Leu Thr Met Ala Ser Gly Gly Gly 
        195                 200                 205             


Ala Pro Val Ala Asp Asn Asn Glu Gly Ala Asp Gly Val Gly Ser Ser 
    210                 215                 220                 


Ser Gly Asn Trp His Cys Asp Ser Gln Trp Leu Gly Asp Arg Val Ile 
225                 230                 235                 240 


Thr Thr Ser Thr Arg Thr Trp Ala Leu Pro Thr Tyr Asn Asn His Leu 
                245                 250                 255     


Tyr Lys Gln Ile Ser Asn Ser Thr Ser Gly Gly Ser Ser Asn Asp Asn 
            260                 265                 270         


Ala Tyr Phe Gly Tyr Ser Thr Pro Trp Gly Tyr Phe Asp Phe Asn Arg 
        275                 280                 285             


Phe His Cys His Phe Ser Pro Arg Asp Trp Gln Arg Leu Ile Asn Asn 
    290                 295                 300                 


Asn Trp Gly Phe Arg Pro Lys Arg Leu Asn Phe Lys Leu Phe Asn Ile 
305                 310                 315                 320 


Gln Val Lys Glu Val Thr Asp Asn Asn Gly Val Lys Thr Ile Ala Asn 
                325                 330                 335     


Asn Leu Thr Ser Thr Val Gln Val Phe Thr Asp Ser Asp Tyr Gln Leu 
            340                 345                 350         


Pro Tyr Val Leu Gly Ser Ala His Glu Gly Cys Leu Pro Pro Phe Pro 
        355                 360                 365             


Ala Asp Val Phe Met Ile Pro Gln Tyr Gly Tyr Leu Thr Leu Asn Asp 
    370                 375                 380                 


Gly Ser Gln Ala Val Gly Arg Ser Ser Phe Tyr Cys Leu Glu Tyr Phe 
385                 390                 395                 400 


Pro Ser Gln Met Leu Arg Thr Gly Asn Asn Phe Gln Phe Ser Tyr Glu 
                405                 410                 415     


Phe Glu Asn Val Pro Phe His Ser Ser Tyr Ala His Ser Gln Ser Leu 
            420                 425                 430         


Asp Arg Leu Met Asn Pro Leu Ile Asp Gln Tyr Leu Tyr Tyr Leu Ser 
        435                 440                 445             


Arg Thr Ile Asn Gly Ser Gly Gln Asn Gln Gln Thr Leu Lys Phe Ser 
    450                 455                 460                 


Val Ala Gly Pro Ser Asn Met Ala Val Gln Gly Arg Asn Tyr Ile Pro 
465                 470                 475                 480 


Gly Pro Ser Tyr Arg Gln Gln Arg Val Ser Thr Thr Val Thr Gln Asn 
                485                 490                 495     


Asn Asn Ser Glu Phe Ala Trp Pro Gly Ala Ser Ser Trp Ala Leu Asn 
            500                 505                 510         


Gly Arg Asn Ser Leu Met Asn Pro Gly Pro Ala Met Ala Ser His Lys 
        515                 520                 525             


Glu Gly Glu Asp Arg Phe Phe Pro Leu Ser Gly Ser Leu Ile Phe Gly 
    530                 535                 540                 


Lys Gln Gly Thr Gly Arg Asp Asn Val Asp Ala Asp Lys Val Met Ile 
545                 550                 555                 560 


Thr Asn Glu Glu Glu Ile Lys Thr Thr Asn Pro Val Ala Thr Glu Ser 
                565                 570                 575     


Tyr Gly Gln Val Ala Thr Asn His Gln Ser Ala Gln Leu Asn Thr Thr 
            580                 585                 590         


Lys Ser Val Met Gln Ala Gln Thr Gly Trp Val Gln Asn Gln Gly Ile 
        595                 600                 605             


Leu Pro Gly Met Val Trp Gln Asp Arg Asp Val Tyr Leu Gln Gly Pro 
    610                 615                 620                 


Ile Trp Ala Lys Ile Pro His Thr Asp Gly Asn Phe His Pro Ser Pro 
625                 630                 635                 640 


Leu Met Gly Gly Phe Gly Met Lys His Pro Pro Pro Gln Ile Leu Ile 
                645                 650                 655     


Lys Asn Thr Pro Val Pro Ala Asp Pro Pro Thr Ala Phe Asn Lys Asp 
            660                 665                 670         


Lys Leu Asn Ser Phe Ile Thr Gln Tyr Ser Thr Gly Gln Val Ser Val 
        675                 680                 685             


Glu Ile Glu Trp Glu Leu Gln Lys Glu Asn Ser Lys Arg Trp Asn Pro 
    690                 695                 700                 


Glu Ile Gln Tyr Thr Ser Asn Tyr Tyr Lys Ser Asn Asn Val Glu Phe 
705                 710                 715                 720 


Ala Val Asn Thr Glu Gly Val Tyr Ser Glu Pro Arg Pro Ile Gly Thr 
                725                 730                 735     


Arg Tyr Leu Thr Arg Asn Leu 
            740             


<210>  70
<211>  743
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthesized

<400>  70

Met Ala Ala Asp Gly Tyr Leu Pro Asp Trp Leu Glu Asp Asn Leu Ser 
1               5                   10                  15      


Glu Gly Ile Arg Glu Trp Trp Ala Leu Lys Pro Gly Ala Pro Gln Pro 
            20                  25                  30          


Lys Ala Asn Gln Gln His Gln Asp Asn Ala Arg Gly Leu Val Leu Pro 
        35                  40                  45              


Gly Tyr Lys Tyr Leu Gly Pro Gly Asn Gly Leu Asp Lys Gly Glu Pro 
    50                  55                  60                  


Val Asn Ala Ala Asp Ala Ala Ala Leu Glu His Asp Lys Ala Tyr Asp 
65                  70                  75                  80  


Gln Gln Leu Lys Ala Gly Asp Asn Pro Tyr Leu Lys Tyr Asn His Ala 
                85                  90                  95      


Asp Ala Glu Phe Gln Glu Arg Leu Lys Glu Asp Thr Ser Phe Gly Gly 
            100                 105                 110         


Asn Leu Gly Arg Ala Val Phe Gln Ala Lys Lys Arg Leu Leu Glu Pro 
        115                 120                 125             


Leu Gly Leu Val Glu Glu Ala Ala Lys Thr Ala Pro Gly Lys Lys Arg 
    130                 135                 140                 


Pro Val Glu Gln Ser Pro Gln Glu Pro Asp Ser Ser Ala Gly Ile Gly 
145                 150                 155                 160 


Lys Ser Gly Ala Gln Pro Ala Lys Lys Arg Leu Asn Phe Gly Gln Thr 
                165                 170                 175     


Gly Asp Thr Glu Ser Val Pro Asp Pro Gln Pro Ile Gly Glu Pro Pro 
            180                 185                 190         


Ala Ala Pro Ser Gly Val Gly Ser Leu Thr Met Ala Ser Gly Gly Gly 
        195                 200                 205             


Ala Pro Val Ala Asp Asn Asn Glu Gly Ala Asp Gly Val Gly Ser Ser 
    210                 215                 220                 


Ser Gly Asn Trp His Cys Asp Ser Gln Trp Leu Gly Asp Arg Val Ile 
225                 230                 235                 240 


Thr Thr Ser Thr Arg Thr Trp Ala Leu Pro Thr Tyr Asn Asn His Leu 
                245                 250                 255     


Tyr Lys Gln Ile Ser Asn Ser Thr Ser Gly Gly Ser Ser Asn Asp Asn 
            260                 265                 270         


Ala Tyr Phe Gly Tyr Ser Thr Pro Trp Gly Tyr Phe Asp Phe Asn Arg 
        275                 280                 285             


Phe His Cys His Phe Ser Pro Arg Asp Trp Gln Arg Leu Ile Asn Asn 
    290                 295                 300                 


Asn Trp Gly Phe Arg Pro Lys Arg Leu Asn Phe Lys Leu Phe Asn Ile 
305                 310                 315                 320 


Gln Val Lys Glu Val Thr Asp Asn Asn Gly Val Lys Thr Ile Ala Asn 
                325                 330                 335     


Asn Leu Thr Ser Thr Val Gln Val Phe Thr Asp Ser Asp Tyr Gln Leu 
            340                 345                 350         


Pro Tyr Val Leu Gly Ser Ala His Glu Gly Cys Leu Pro Pro Phe Pro 
        355                 360                 365             


Ala Asp Val Phe Met Ile Pro Gln Tyr Gly Tyr Leu Thr Leu Asn Asp 
    370                 375                 380                 


Gly Ser Gln Ala Val Gly Arg Ser Ser Phe Tyr Cys Leu Glu Tyr Phe 
385                 390                 395                 400 


Pro Ser Gln Met Leu Arg Thr Gly Asn Asn Phe Gln Phe Ser Tyr Glu 
                405                 410                 415     


Phe Glu Asn Val Pro Phe His Ser Ser Tyr Ala His Ser Gln Ser Leu 
            420                 425                 430         


Asp Arg Leu Met Asn Pro Leu Ile Asp Gln Tyr Leu Tyr Tyr Leu Ser 
        435                 440                 445             


Arg Thr Ile Asn Gly Ser Gly Gln Asn Gln Gln Thr Leu Lys Phe Ser 
    450                 455                 460                 


Val Ala Gly Pro Ser Asn Met Ala Val Gln Gly Arg Asn Tyr Ile Pro 
465                 470                 475                 480 


Gly Pro Ser Tyr Arg Gln Gln Arg Val Ser Thr Thr Val Thr Gln Asn 
                485                 490                 495     


Asn Asn Ser Glu Phe Ala Trp Pro Gly Ala Ser Ser Trp Ala Leu Asn 
            500                 505                 510         


Gly Arg Asn Ser Leu Met Asn Pro Gly Pro Ala Met Ala Ser His Lys 
        515                 520                 525             


Glu Gly Glu Asp Arg Phe Phe Pro Leu Ser Gly Ser Leu Ile Phe Gly 
    530                 535                 540                 


Lys Gln Gly Thr Gly Arg Asp Asn Val Asp Ala Asp Lys Val Met Ile 
545                 550                 555                 560 


Thr Asn Glu Glu Glu Ile Lys Thr Thr Asn Pro Val Ala Thr Glu Ser 
                565                 570                 575     


Tyr Gly Gln Val Ala Thr Asn His Gln Ser Ala Gln Leu Asn Thr Thr 
            580                 585                 590         


Lys Asn Val Thr Gln Ala Gln Thr Gly Trp Val Gln Asn Gln Gly Ile 
        595                 600                 605             


Leu Pro Gly Met Val Trp Gln Asp Arg Asp Val Tyr Leu Gln Gly Pro 
    610                 615                 620                 


Ile Trp Ala Lys Ile Pro His Thr Asp Gly Asn Phe His Pro Ser Pro 
625                 630                 635                 640 


Leu Met Gly Gly Phe Gly Met Lys His Pro Pro Pro Gln Ile Leu Ile 
                645                 650                 655     


Lys Asn Thr Pro Val Pro Ala Asp Pro Pro Thr Ala Phe Asn Lys Asp 
            660                 665                 670         


Lys Leu Asn Ser Phe Ile Thr Gln Tyr Ser Thr Gly Gln Val Ser Val 
        675                 680                 685             


Glu Ile Glu Trp Glu Leu Gln Lys Glu Asn Ser Lys Arg Trp Asn Pro 
    690                 695                 700                 


Glu Ile Gln Tyr Thr Ser Asn Tyr Tyr Lys Ser Asn Asn Val Glu Phe 
705                 710                 715                 720 


Ala Val Asn Thr Glu Gly Val Tyr Ser Glu Pro Arg Pro Ile Gly Thr 
                725                 730                 735     


Arg Tyr Leu Thr Arg Asn Leu 
            740             


<210>  71
<211>  2211
<212>  DNA
<213>  adeno-associated virus 9

<400>  71
atggctgccg atggttatct tccagattgg ctcgaggaca accttagtga aggaattcgc       60

gagtggtggg ctttgaaacc tggagcccct caacccaagg caaatcaaca acatcaagac      120

aacgctcgag gtcttgtgct tccgggttac aaataccttg gacccggcaa cggactcgac      180

aagggggagc cggtcaacgc agcagacgcg gcggccctcg agcacgacaa ggcctacgac      240

cagcagctca aggccggaga caacccgtac ctcaagtaca accacgccga cgccgagttc      300

caggagcggc tcaaagaaga tacgtctttt gggggcaacc tcgggcgagc agtcttccag      360

gccaaaaaga ggcttcttga acctcttggt ctggttgagg aagcggctaa gacggctcct      420

ggaaagaaga ggcctgtaga gcagtctcct caggaaccgg actcctccgc gggtattggc      480

aaatcgggtg cacagcccgc taaaaagaga ctcaatttcg gtcagactgg cgacacagag      540

tcagtcccag accctcaacc aatcggagaa cctcccgcag ccccctcagg tgtgggatct      600

cttacaatgg cttcaggtgg tggcgcacca gtggcagaca ataacgaagg tgccgatgga      660

gtgggtagtt cctcgggaaa ttggcattgc gattcccaat ggctggggga cagagtcatc      720

accaccagca cccgaacctg ggccctgccc acctacaaca atcacctcta caagcaaatc      780

tccaacagca catctggagg atcttcaaat gacaacgcct acttcggcta cagcaccccc      840

tgggggtatt ttgacttcaa cagattccac tgccacttct caccacgtga ctggcagcga      900

ctcatcaaca acaactgggg attccggcct aagcgactca acttcaagct cttcaacatt      960

caggtcaaag aggttacgga caacaatgga gtcaagacca tcgccaataa ccttaccagc     1020

acggtccagg tcttcacgga ctcagactat cagctcccgt acgtgctcgg gtcggctcac     1080

gagggctgcc tcccgccgtt cccagcggac gttttcatga ttcctcagta cgggtatctg     1140

acgcttaatg atggaagcca ggccgtgggt cgttcgtcct tttactgcct ggaatatttc     1200

ccgtcgcaaa tgctaagaac gggtaacaac ttccagttca gctacgagtt tgagaacgta     1260

cctttccata gcagctacgc tcacagccaa agcctggacc gactaatgaa tccactcatc     1320

gaccaatact tgtactatct ctcaaagact attaacggtt ctggacagaa tcaacaaacg     1380

ctaaaattca gtgtggccgg acccagcaac atggctgtcc agggaagaaa ctacatacct     1440

ggacccagct accgacaaca acgtgtctca accactgtga ctcaaaacaa caacagcgaa     1500

tttgcttggc ctggagcttc ttcttgggct ctcaatggac gtaatagctt gatgaatcct     1560

ggacctgcta tggccagcca caaagaagga gaggaccgtt tctttccttt gtctggatct     1620

ttaatttttg gcaaacaagg aactggaaga gacaacgtgg atgcggacaa agtcatgata     1680

accaacgaag aagaaattaa aactactaac ccggtagcaa cggagtccta tggacaagtg     1740

gccacaaacc accagagtgc ccaagcacag gcgcagaccg gctgggttca aaaccaagga     1800

atacttccgg gtatggtttg gcaggacaga gatgtgtacc tgcaaggacc catttgggcc     1860

aaaattcctc acacggacgg caactttcac ccttctccgc tgatgggagg gtttggaatg     1920

aagcacccgc ctcctcagat cctcatcaaa aacacacctg tacctgcgga tcctccaacg     1980

gccttcaaca aggacaagct gaactctttc atcacccagt attctactgg ccaagtcagc     2040

gtggagatcg agtgggagct gcagaaggaa aacagcaagc gctggaaccc ggagatccag     2100

tacacttcca actattacaa gtctaataat gttgaatttg ctgttaatac tgaaggtgta     2160

tatagtgaac cccgccccat tggcaccaga tacctgactc gtaatctgta a              2211


<210>  72
<211>  33
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Synthesized

<400>  72
gctcagttga atactactaa gtctgttatg cag                                    33


<210>  73
<211>  33
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Synthesized

<400>  73
gctcagttga atactactaa gcctactgat cgt                                    33


<210>  74
<211>  33
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Synthesized

<400>  74
gctcagttga atactactaa gcctactgtt ggt                                    33


<210>  75
<211>  33
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Synthesized

<400>  75
gctcagttga atactactaa gccttctcct ggt                                    33


<210>  76
<211>  33
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Synthesized

<400>  76
gctcagttga atactactaa gcctactggt cct                                    33


<210>  77
<211>  33
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Synthesized

<400>  77
gctcagttga atactactaa gcctactgct ggt                                    33


<210>  78
<211>  33
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Synthesized

<400>  78
gctcagttga atactactaa gcctgttgct ggt                                    33


<210>  79
<211>  33
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Synthesized

<400>  79
gctcagttga atactactaa gaatattact cag                                    33


<210>  80
<211>  33
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Synthesized

<400>  80
gctcagttga atactactaa gcctacttct ttt                                    33


<210>  81
<211>  33
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Synthesized

<400>  81
gctcagttga atactactaa gcctactcct tct                                    33


<210>  82
<211>  33
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Synthesized

<400>  82
atggctaata atactactaa gcctattgct cag                                    33


<210>  83
<211>  33
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Synthesized

<400>  83
gctcagttga atactactaa gcctattgct cag                                    33


<210>  84
<211>  33
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Synthesized

<400>  84
gctcagttga atactactaa gcctacttct tat                                    33


<210>  85
<211>  33
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Synthesized

<400>  85
gctcagttga atactactaa gaatatgact cag                                    33


<210>  86
<211>  33
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Synthesized

<400>  86
gctcagttga atactactaa gcctcgtgat gag                                    33


<210>  87
<211>  33
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Synthesized

<400>  87
gctcagttga atactactaa gcctactgct cag                                    33


<210>  88
<211>  33
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Synthesized

<400>  88
gctcagttga atactactaa gaatgttact cag                                    33


<210>  89
<211>  33
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Synthesized

<400>  89
cagactaata atactactaa gcctattgct cag                                    33


<210>  90
<211>  33
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Synthesized

<400>  90
gctcagttga atactactaa gcagatgaat cag                                    33


<210>  91
<211>  33
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Synthesized

<400>  91
gctcagttga atactactaa gcatgttgat cag                                    33


<210>  92
<211>  33
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Synthesized

<400>  92
gctcagttga atactactaa gcagattgat cag                                    33


<210>  93
<211>  33
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Synthesized

<400>  93
gttgctttga atactactaa gcctattgct cag                                    33


<210>  94
<211>  33
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Synthesized

<400>  94
gctatgacta atactactaa gcctattgct cag                                    33


<210>  95
<211>  33
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Synthesized

<400>  95
gctcagttga atactactaa gcctgctaat cag                                    33


<210>  96
<211>  33
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Synthesized

<400>  96
gctcagttga atactactaa gaatgttaat cag                                    33


<210>  97
<211>  33
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Synthesized

<400>  97
gctcagttga atactactaa gcctgttgtt gct                                    33


<210>  98
<211>  33
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Synthesized

<400>  98
gctcagttga atactactaa gcctcagaat cag                                    33


<210>  99
<211>  33
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Synthesized

<400>  99
gctcagttga atactactaa gcctcagttg cag                                    33


<210>  100
<211>  33
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Synthesized

<400>  100
gctcagttga atactactaa gattactgat cag                                    33


<210>  101
<211>  33
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Synthesized

<400>  101
gctcagttga atactactaa gttgcatgat cag                                    33


<210>  102
<211>  33
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Synthesized

<400>  102
gctcagttga atactactaa gaatggttat cag                                    33


<210>  103
<211>  33
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Synthesized

<400>  103
gctaatgtta atactactaa gcctattgct cag                                    33


<210>  104
<211>  33
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Synthesized

<400>  104
gagcagatga atactactaa gcctattgct cag                                    33


<210>  105
<211>  33
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Synthesized

<400>  105
gctcagttga atactactaa gcctttgcag ttt                                    33


<210>  106
<211>  33
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Synthesized

<400>  106
gctcagttga atactactaa gccttcttct ggt                                    33


<210>  107
<211>  33
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Synthesized

<400>  107
gctcagttga atactactaa gcctgttatg cag                                    33


<210>  108
<211>  33
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Synthesized

<400>  108
gctcagttga atactactaa gcctttggct cag                                    33


<210>  109
<211>  33
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Synthesized

<400>  109
actattacta atactactaa gcctattgct cag                                    33


<210>  110
<211>  33
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Synthesized

<400>  110
gctcagttga atactactaa gtcttttggt cag                                    33


<210>  111
<211>  11
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthesized


<220>
<221>  MISC_FEATURE
<222>  (1)..(1)
<223>  A, E, Q, T or V

<220>
<221>  MISC_FEATURE
<222>  (2)..(2)
<223>  Q, I, M, A, P, or V

<220>
<221>  MISC_FEATURE
<222>  (3)..(3)
<223>  L, S, Q, M or T

<220>
<221>  MISC_FEATURE
<222>  (7)..(7)
<223>  K or R

<220>
<221>  MISC_FEATURE
<222>  (8)..(8)
<223>  P, I, N, A, Q, H, I, V, S or L

<220>
<221>  MISC_FEATURE
<222>  (9)..(9)
<223>  T, I, V, A, Q, S, L, M, G, H or R

<220>
<221>  MISC_FEATURE
<222>  (10)..(10)
<223>  A, D, N, S, T, M, P, Q, E, G, V, I or W

<220>
<221>  MISC_FEATURE
<222>  (11)..(11)
<223>  Q, G, F, A, S, D, E, M, P, R, T or Y

<400>  111

Xaa Xaa Xaa Asn Thr Thr Xaa Xaa Xaa Xaa Xaa 
1               5                   10      


<210>  112
<211>  11
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthesized

<400>  112

Ala Gln Leu Asn Thr Thr Lys Asp Val His Gln 
1               5                   10      


<210>  113
<211>  11
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthesized

<400>  113

Ala Gln Leu Asn Thr Thr Lys Asn Gly Thr Gln 
1               5                   10      


<210>  114
<211>  7
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthesized

<400>  114

Leu Ala Leu Pro Lys Pro Ile 
1               5           


<210>  115
<211>  11
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthesized

<400>  115

Ala Gln Leu Asn Thr Thr Lys Pro Leu Asn Pro 
1               5                   10      


<210>  116
<211>  11
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthesized

<400>  116

Ala Gln Leu Ala Leu Pro Lys Pro Ile Ala Gln 
1               5                   10      


<210>  117
<211>  11
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthesized

<400>  117

Ala Gln Leu Asn Thr Thr Lys Pro Thr Thr Ser 
1               5                   10      


<210>  118
<211>  1653
<212>  DNA
<213>  homo sapiens

<400>  118
atgccgccac cccggaccgg ccgaggcctt ctctggctgg gtctggttct gagctccgtc       60

tgcgtcgccc tcggatccga aacgcaggcc aactcgacca cagatgctct gaacgttctt      120

ctcatcatcg tggatgacct gcgcccctcc ctgggctgtt atggggataa gctggtgagg      180

tccccaaata ttgaccaact ggcatcccac agcctcctct tccagaatgc ctttgcgcag      240

caagcagtgt gcgccccgag ccgcgtttct ttcctcactg gcaggagacc tgacaccacc      300

cgcctgtacg acttcaactc ctactggagg gtgcacgctg gaaacttctc caccatcccc      360

cagtacttca aggagaatgg ctatgtgacc atgtcggtgg gaaaagtctt tcaccctggg      420

atatcttcta accataccga tgattctccg tatagctggt cttttccacc ttatcatcct      480

tcctctgaga agtatgaaaa cactaagaca tgtcgagggc cagatggaga actccatgcc      540

aacctgcttt gccctgtgga tgtgctggat gttcccgagg gcaccttgcc tgacaaacag      600

agcactgagc aagccataca gttgttggaa aagatgaaaa cgtcagccag tcctttcttc      660

ctggccgttg ggtatcataa gccacacatc cccttcagat accccaagga atttcagaag      720

ttgtatccct tggagaacat caccctggcc cccgatcccg aggtccctga tggcctaccc      780

cctgtggcct acaacccctg gatggacatc aggcaacggg aagacgtcca agccttaaac      840

atcagtgtgc cgtatggtcc aattcctgtg gactttcagc ggaaaatccg ccagagctac      900

tttgcctctg tgtcatattt ggatacacag gtcggccgcc tcttgagtgc tttggacgat      960

cttcagctgg ccaacagcac catcattgca tttacctcgg atcatgggtg ggctctaggt     1020

gaacatggag aatgggccaa atacagcaat tttgatgttg ctacccatgt tcccctgata     1080

ttctatgttc ctggaaggac ggcttcactt ccggaggcag gcgagaagct tttcccttac     1140

ctcgaccctt ttgattccgc ctcacagttg atggagccag gcaggcaatc catggacctt     1200

gtggaacttg tgtctctttt tcccacgctg gctggacttg caggactgca ggttccacct     1260

cgctgccccg ttccttcatt tcacgttgag ctgtgcagag aaggcaagaa ccttctgaag     1320

cattttcgat tccgtgactt ggaagaggat ccgtacctcc ctggtaatcc ccgtgaactg     1380

attgcctata gccagtatcc ccggccttca gacatccctc agtggaattc tgacaagccg     1440

agtttaaaag atataaagat catgggctat tccatacgca ccatagacta taggtatact     1500

gtgtgggttg gcttcaatcc tgatgaattt ctagctaact tttctgacat ccatgcaggg     1560

gaactgtatt ttgtggattc tgacccattg caggatcaca atatgtataa tgattcccaa     1620

ggtggagatc ttttccagtt gttgatgcct tga                                  1653


<210>  119
<211>  1100
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Synthesized

<400>  119
ttattaatag taatcaatta cggggtcatt agttcatagc ccatatatgg agttccgcgt       60

tacataactt acggtaaatg gcccgcctgg ctgaccgccc aacgaccccc gcccattgac      120

gtcaataatg acgtatgttc ccatagtaac gccaataggg actttccatt gacgtcaatg      180

ggtggagtat ttacggtaaa ctgcccactt ggcagtacat caagtgtatc atatgccaag      240

tacgccccct attgacgtca atgacggtaa atggcccgcc tggcattatg cccagtacat      300

gaccttatgg gactttccta cttggcagta catctacgta ttagtcatcg ctattaccat      360

ggtcgaggtg agccccacgt tctgcttcac tctccccatc tcccccccct ccccaccccc      420

aattttgtat ttatttattt tttaattatt ttgtgcagcg atgggggcgg gggggggggg      480

ggggcgcgcg ccaggcgggg cggggcgggg cgaggggcgg ggcggggcga ggcggagagg      540

tgcggcggca gccaatcaga gcggcgcgct ccgaaagttt ccttttatgg cgaggcggcg      600

gcggcggcgg ccctataaaa agcgaagcgc gcggcgggcg ggagtcgctg cgcgctgcct      660

tcgccccgtg ccccgctccg ccgccgcctc gcgccgcccg ccccggctct gactgaccgc      720

gttactccca caggtgagcg ggcgggacgg cccttctcct ccgggctgta attagcgctt      780

ggtttaatga cggcttgttt cttttctgtg gctgcgtgaa agccttgagg ggctccggga      840

gcgccggcag gaaggaaatg ggcggggagg gccttcgtgc gtcgccgcgc cgccgtcccc      900

ttctccctct ccagcctcgg ggctgtccgc ggggggacgg ctgccttcgg gggggacggg      960

gcagggcggg gttcggcttc tggcgtgtga ccggcggctc tagagcctct gctaaccatg     1020

ttcatgcctt cttctttttc ctacagctcc tgggcaacgt gctggttatt gtgctgtctc     1080

atcattttgg caaagaattg                                                 1100


<210>  120
<211>  793
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Synthesized

<400>  120
cgttacataa cttacggtaa atggcccgcc tggctgaccg cccaacgacc cccgcccatt       60

gacgtcaata gtaacgccaa tagggacttt ccattgacgt caatgggtgg agtatttacg      120

gtaaactgcc cacttggcag tacatcaagt gtatcatatg ccaagtacgc cccctattga      180

cgtcaatgac ggtaaatggc ccgcctggca ttgtgcccag tacatgacct tatgggactt      240

tcctacttgg cagtacatct acgtattagt catcgctatt accatggtcg aggtgagccc      300

cacgttctgc ttcactctcc ccatctcccc cccctcccca cccccaattt tgtatttatt      360

tattttttaa ttattttgtg cagcgatggg ggcggggggg gggggggggc gcgcgccagg      420

cggggcgggg cggggcgagg ggcggggcgg ggcgaggcgg agaggtgcgg cggcagccaa      480

tcagagcggc gcgctccgaa agtttccttt tatggcgagg cggcggcggc ggcggcccta      540

taaaaagcga agcgcgcggc gggcgggagt cgctgcgcgc tgccttcgcc ccgtgccccg      600

ctccgccgcc gcctcgcgcc gcccgccccg gctctgactg accgcgttac tcccacaggt      660

gagcgggcgg gacggccctt ctcctccggg ctgtaattag ctgagcaaga ggtaagggtt      720

taagggatgg ttggttggtg gggtattaat gtttaattac ctggagcacc tgcctgaaat      780

cacttttttt cag                                                         793


<210>  121
<211>  469
<212>  DNA
<213>  homo sapiens

<400>  121
ctgcagaggg ccctgcgtat gagtgcaagt gggttttagg accaggatga ggcggggtgg       60

gggtgcctac ctgacgaccg accccgaccc actggacaag cacccaaccc ccattcccca      120

aattgcgcat cccctatcag agagggggag gggaaacagg atgcggcgag gcgcgtgcgc      180

actgccagct tcagcaccgc ggacagtgcc ttcgcccccg cctggcggcg cgcgccaccg      240

ccgcctcagc actgaaggcg cgctgacgtc actcgccggt cccccgcaaa ctccccttcc      300

cggccacctt ggtcgcgtcc gcgccgccgc cggcccagcc ggaccgcacc acgcgaggcg      360

cgagataggg gggcacgggc gcgaccatct gcgctgcggc gccggcgact cagcgctgcc      420

tcagtctgcg gtgggcagcg gaggagtcgt gtcgtgcctg agagcgcag                  469


<210>  122
<211>  617
<212>  DNA
<213>  Woodchuck hepatitis B virus

<400>  122
gatatcaagc ttatcgataa tcaacctctg gattacaaaa tttgtgaaag attgactggt       60

attcttaact atgttgctcc ttttacgcta tgtggatacg ctgctttaat gcctttgtat      120

catgctattg cttcccgtat ggctttcatt ttctcctcct tgtataaatc ctggttgctg      180

tctctttatg aggagttgtg gcccgttgtc aggcaacgtg gcgtggtgtg cactgtgttt      240

gctgacgcaa cccccactgg ttggggcatt gccaccacct gtcagctcct ttccgggact      300

ttcgctttcc ccctccctat tgccacggcg gaactcatcg ccgcctgcct tgcccgctgc      360

tggacagggg ctcggctgtt gggcactgac aattccgtgg tgttgtcggg gaaatcatcg      420

tcctttcctt ggctgctcgc ctgtgttgcc acctggattc tgcgcgggac gtccttctgc      480

tacgtccctt cggccctcaa tccagcggac cttccttccc gcggcctgct gccggctctg      540

cggcctcttc cgcgtcttcg ccttcgccct cagacgagtc ggatctccct ttgggccgcc      600

tccccgcatc gataccg                                                     617


<210>  123
<211>  479
<212>  DNA
<213>  homo sapiens

<400>  123
acgggtggca tccctgtgac ccctccccag tgcctctcct ggccctggaa gttgccactc       60

cagtgcccac cagccttgtc ctaataaaat taagttgcat cattttgtct gactaggtgt      120

ccttctataa tattatgggg tggagggggg tggtatggag caaggggcaa gttgggaaga      180

caacctgtag ggcctgcggg gtctattggg aaccaagctg gagtgcagtg gcacaatctt      240

ggctcactgc aatctccgcc tcctgggttc aagcgattct cctgcctcag cctcccgagt      300

tgttgggatt ccaggcatgc atgaccaggc tcagctaatt tttgtttttt tggtagagac      360

ggggtttcac catattggcc aggctggtct ccaactccta atctcaggtg atctacccac      420

cttggcctcc caaattgctg ggattacagg cgtgaaccac tgctcccttc cctgtcctt       479


<210>  124
<211>  233
<212>  DNA
<213>  Simian virus 40

<400>  124
ttcgagcaga catgataaga tacattgatg agtttggaca aaccacaact agaatgcagt       60

gaaaaaaatg ctttatttgt gaaatttgtg atgctattgc tttatttgta accattataa      120

gctgcaataa acaagttaac aacaacaatt gcattcattt tatgtttcag gttcaggggg      180

agatgtggga ggttttttaa agcaagtaaa acctctacaa atgtggtaaa atc             233


<210>  125
<211>  7
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthesized

<400>  125

Lys Asp Asn Thr Pro Gly Arg 
1               5           


<210>  126
<211>  7
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthesized

<400>  126

Asp Gly Ala Ala Thr Lys Asn 
1               5           


<210>  127
<211>  743
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthesized

<400>  127

Met Ala Ala Asp Gly Tyr Leu Pro Asp Trp Leu Glu Asp Asn Leu Ser 
1               5                   10                  15      


Glu Gly Ile Arg Glu Trp Trp Ala Leu Lys Pro Gly Ala Pro Gln Pro 
            20                  25                  30          


Lys Ala Asn Gln Gln His Gln Asp Asn Ala Arg Gly Leu Val Leu Pro 
        35                  40                  45              


Gly Tyr Lys Tyr Leu Gly Pro Gly Asn Gly Leu Asp Lys Gly Glu Pro 
    50                  55                  60                  


Val Asn Ala Ala Asp Ala Ala Ala Leu Glu His Asp Lys Ala Tyr Asp 
65                  70                  75                  80  


Gln Gln Leu Lys Ala Gly Asp Asn Pro Tyr Leu Lys Tyr Asn His Ala 
                85                  90                  95      


Asp Ala Glu Phe Gln Glu Arg Leu Lys Glu Asp Thr Ser Phe Gly Gly 
            100                 105                 110         


Asn Leu Gly Arg Ala Val Phe Gln Ala Lys Lys Arg Leu Leu Glu Pro 
        115                 120                 125             


Leu Gly Leu Val Glu Glu Ala Ala Lys Thr Ala Pro Gly Lys Lys Arg 
    130                 135                 140                 


Pro Val Glu Gln Ser Pro Gln Glu Pro Asp Ser Ser Ala Gly Ile Gly 
145                 150                 155                 160 


Lys Ser Gly Ala Gln Pro Ala Lys Lys Arg Leu Asn Phe Gly Gln Thr 
                165                 170                 175     


Gly Asp Thr Glu Ser Val Pro Asp Pro Gln Pro Ile Gly Glu Pro Pro 
            180                 185                 190         


Ala Ala Pro Ser Gly Val Gly Ser Leu Thr Met Ala Ser Gly Gly Gly 
        195                 200                 205             


Ala Pro Val Ala Asp Asn Asn Glu Gly Ala Asp Gly Val Gly Ser Ser 
    210                 215                 220                 


Ser Gly Asn Trp His Cys Asp Ser Gln Trp Leu Gly Asp Arg Val Ile 
225                 230                 235                 240 


Thr Thr Ser Thr Arg Thr Trp Ala Leu Pro Thr Tyr Asn Asn His Leu 
                245                 250                 255     


Tyr Lys Gln Ile Ser Asn Ser Thr Ser Gly Gly Ser Ser Asn Asp Asn 
            260                 265                 270         


Ala Tyr Phe Gly Tyr Ser Thr Pro Trp Gly Tyr Phe Asp Phe Asn Arg 
        275                 280                 285             


Phe His Cys His Phe Ser Pro Arg Asp Trp Gln Arg Leu Ile Asn Asn 
    290                 295                 300                 


Asn Trp Gly Phe Arg Pro Lys Arg Leu Asn Phe Lys Leu Phe Asn Ile 
305                 310                 315                 320 


Gln Val Lys Glu Val Thr Asp Asn Asn Gly Val Lys Thr Ile Ala Asn 
                325                 330                 335     


Asn Leu Thr Ser Thr Val Gln Val Phe Thr Asp Ser Asp Tyr Gln Leu 
            340                 345                 350         


Pro Tyr Val Leu Gly Ser Ala His Glu Gly Cys Leu Pro Pro Phe Pro 
        355                 360                 365             


Ala Asp Val Phe Met Ile Pro Gln Tyr Gly Tyr Leu Thr Leu Asn Asp 
    370                 375                 380                 


Gly Ser Gln Ala Val Gly Arg Ser Ser Phe Tyr Cys Leu Glu Tyr Phe 
385                 390                 395                 400 


Pro Ser Gln Met Leu Arg Thr Gly Asn Asn Phe Gln Phe Ser Tyr Glu 
                405                 410                 415     


Phe Glu Asn Val Pro Phe His Ser Ser Tyr Ala His Ser Gln Ser Leu 
            420                 425                 430         


Asp Arg Leu Met Asn Pro Leu Ile Asp Gln Tyr Leu Tyr Tyr Leu Ser 
        435                 440                 445             


Arg Thr Ile Asn Gly Ser Gly Gln Asn Gln Gln Thr Leu Lys Phe Ser 
    450                 455                 460                 


Val Ala Gly Pro Ser Asn Met Ala Val Gln Gly Arg Asn Tyr Ile Pro 
465                 470                 475                 480 


Gly Pro Ser Tyr Arg Gln Gln Arg Val Ser Thr Thr Val Thr Gln Asn 
                485                 490                 495     


Asn Asn Ser Glu Phe Ala Trp Pro Gly Ala Ser Ser Trp Ala Leu Asn 
            500                 505                 510         


Gly Arg Asn Ser Leu Met Asn Pro Gly Pro Ala Met Ala Ser His Lys 
        515                 520                 525             


Glu Gly Glu Asp Arg Phe Phe Pro Leu Ser Gly Ser Leu Ile Phe Gly 
    530                 535                 540                 


Lys Gln Gly Thr Gly Arg Asp Asn Val Asp Ala Asp Lys Val Met Ile 
545                 550                 555                 560 


Thr Asn Glu Glu Glu Ile Lys Thr Thr Asn Pro Val Ala Thr Glu Ser 
                565                 570                 575     


Tyr Gly Gln Val Ala Thr Asn His Gln Ser Ala Gln Leu Ala Leu Pro 
            580                 585                 590         


Lys Pro Ile Ala Gln Ala Gln Thr Gly Trp Val Gln Asn Gln Gly Ile 
        595                 600                 605             


Leu Pro Gly Met Val Trp Gln Asp Arg Asp Val Tyr Leu Gln Gly Pro 
    610                 615                 620                 


Ile Trp Ala Lys Ile Pro His Thr Asp Gly Asn Phe His Pro Ser Pro 
625                 630                 635                 640 


Leu Met Gly Gly Phe Gly Met Lys His Pro Pro Pro Gln Ile Leu Ile 
                645                 650                 655     


Lys Asn Thr Pro Val Pro Ala Asp Pro Pro Thr Ala Phe Asn Lys Asp 
            660                 665                 670         


Lys Leu Asn Ser Phe Ile Thr Gln Tyr Ser Thr Gly Gln Val Ser Val 
        675                 680                 685             


Glu Ile Glu Trp Glu Leu Gln Lys Glu Asn Ser Lys Arg Trp Asn Pro 
    690                 695                 700                 


Glu Ile Gln Tyr Thr Ser Asn Tyr Tyr Lys Ser Asn Asn Val Glu Phe 
705                 710                 715                 720 


Ala Val Asn Thr Glu Gly Val Tyr Ser Glu Pro Arg Pro Ile Gly Thr 
                725                 730                 735     


Arg Tyr Leu Thr Arg Asn Leu 
            740             


<210>  128
<211>  743
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthesized

<400>  128

Met Ala Ala Asp Gly Tyr Leu Pro Asp Trp Leu Glu Asp Asn Leu Ser 
1               5                   10                  15      


Glu Gly Ile Arg Glu Trp Trp Ala Leu Lys Pro Gly Ala Pro Gln Pro 
            20                  25                  30          


Lys Ala Asn Gln Gln His Gln Asp Asn Ala Arg Gly Leu Val Leu Pro 
        35                  40                  45              


Gly Tyr Lys Tyr Leu Gly Pro Gly Asn Gly Leu Asp Lys Gly Glu Pro 
    50                  55                  60                  


Val Asn Ala Ala Asp Ala Ala Ala Leu Glu His Asp Lys Ala Tyr Asp 
65                  70                  75                  80  


Gln Gln Leu Lys Ala Gly Asp Asn Pro Tyr Leu Lys Tyr Asn His Ala 
                85                  90                  95      


Asp Ala Glu Phe Gln Glu Arg Leu Lys Glu Asp Thr Ser Phe Gly Gly 
            100                 105                 110         


Asn Leu Gly Arg Ala Val Phe Gln Ala Lys Lys Arg Leu Leu Glu Pro 
        115                 120                 125             


Leu Gly Leu Val Glu Glu Ala Ala Lys Thr Ala Pro Gly Lys Lys Arg 
    130                 135                 140                 


Pro Val Glu Gln Ser Pro Gln Glu Pro Asp Ser Ser Ala Gly Ile Gly 
145                 150                 155                 160 


Lys Ser Gly Ala Gln Pro Ala Lys Lys Arg Leu Asn Phe Gly Gln Thr 
                165                 170                 175     


Gly Asp Thr Glu Ser Val Pro Asp Pro Gln Pro Ile Gly Glu Pro Pro 
            180                 185                 190         


Ala Ala Pro Ser Gly Val Gly Ser Leu Thr Met Ala Ser Gly Gly Gly 
        195                 200                 205             


Ala Pro Val Ala Asp Asn Asn Glu Gly Ala Asp Gly Val Gly Ser Ser 
    210                 215                 220                 


Ser Gly Asn Trp His Cys Asp Ser Gln Trp Leu Gly Asp Arg Val Ile 
225                 230                 235                 240 


Thr Thr Ser Thr Arg Thr Trp Ala Leu Pro Thr Tyr Asn Asn His Leu 
                245                 250                 255     


Tyr Lys Gln Ile Ser Asn Ser Thr Ser Gly Gly Ser Ser Asn Asp Asn 
            260                 265                 270         


Ala Tyr Phe Gly Tyr Ser Thr Pro Trp Gly Tyr Phe Asp Phe Asn Arg 
        275                 280                 285             


Phe His Cys His Phe Ser Pro Arg Asp Trp Gln Arg Leu Ile Asn Asn 
    290                 295                 300                 


Asn Trp Gly Phe Arg Pro Lys Arg Leu Asn Phe Lys Leu Phe Asn Ile 
305                 310                 315                 320 


Gln Val Lys Glu Val Thr Asp Asn Asn Gly Val Lys Thr Ile Ala Asn 
                325                 330                 335     


Asn Leu Thr Ser Thr Val Gln Val Phe Thr Asp Ser Asp Tyr Gln Leu 
            340                 345                 350         


Pro Tyr Val Leu Gly Ser Ala His Glu Gly Cys Leu Pro Pro Phe Pro 
        355                 360                 365             


Ala Asp Val Phe Met Ile Pro Gln Tyr Gly Tyr Leu Thr Leu Asn Asp 
    370                 375                 380                 


Gly Ser Gln Ala Val Gly Arg Ser Ser Phe Tyr Cys Leu Glu Tyr Phe 
385                 390                 395                 400 


Pro Ser Gln Met Leu Arg Thr Gly Asn Asn Phe Gln Phe Ser Tyr Glu 
                405                 410                 415     


Phe Glu Asn Val Pro Phe His Ser Ser Tyr Ala His Ser Gln Ser Leu 
            420                 425                 430         


Asp Arg Leu Met Asn Pro Leu Ile Asp Gln Tyr Leu Tyr Tyr Leu Ser 
        435                 440                 445             


Arg Thr Ile Asn Gly Ser Gly Gln Asn Gln Gln Thr Leu Lys Phe Ser 
    450                 455                 460                 


Val Ala Gly Pro Ser Asn Met Ala Val Gln Gly Arg Asn Tyr Ile Pro 
465                 470                 475                 480 


Gly Pro Ser Tyr Arg Gln Gln Arg Val Ser Thr Thr Val Thr Gln Asn 
                485                 490                 495     


Asn Asn Ser Glu Phe Ala Trp Pro Gly Ala Ser Ser Trp Ala Leu Asn 
            500                 505                 510         


Gly Arg Asn Ser Leu Met Asn Pro Gly Pro Ala Met Ala Ser His Lys 
        515                 520                 525             


Glu Gly Glu Asp Arg Phe Phe Pro Leu Ser Gly Ser Leu Ile Phe Gly 
    530                 535                 540                 


Lys Gln Gly Thr Gly Arg Asp Asn Val Asp Ala Asp Lys Val Met Ile 
545                 550                 555                 560 


Thr Asn Glu Glu Glu Ile Lys Thr Thr Asn Pro Val Ala Thr Glu Ser 
                565                 570                 575     


Tyr Gly Gln Val Ala Thr Asn His Gln Ser Ala Gln Leu Asn Thr Thr 
            580                 585                 590         


Lys Pro Thr Thr Ser Ala Gln Thr Gly Trp Val Gln Asn Gln Gly Ile 
        595                 600                 605             


Leu Pro Gly Met Val Trp Gln Asp Arg Asp Val Tyr Leu Gln Gly Pro 
    610                 615                 620                 


Ile Trp Ala Lys Ile Pro His Thr Asp Gly Asn Phe His Pro Ser Pro 
625                 630                 635                 640 


Leu Met Gly Gly Phe Gly Met Lys His Pro Pro Pro Gln Ile Leu Ile 
                645                 650                 655     


Lys Asn Thr Pro Val Pro Ala Asp Pro Pro Thr Ala Phe Asn Lys Asp 
            660                 665                 670         


Lys Leu Asn Ser Phe Ile Thr Gln Tyr Ser Thr Gly Gln Val Ser Val 
        675                 680                 685             


Glu Ile Glu Trp Glu Leu Gln Lys Glu Asn Ser Lys Arg Trp Asn Pro 
    690                 695                 700                 


Glu Ile Gln Tyr Thr Ser Asn Tyr Tyr Lys Ser Asn Asn Val Glu Phe 
705                 710                 715                 720 


Ala Val Asn Thr Glu Gly Val Tyr Ser Glu Pro Arg Pro Ile Gly Thr 
                725                 730                 735     


Arg Tyr Leu Thr Arg Asn Leu 
            740             


<210>  129
<211>  110
<212>  DNA
<213>  homo sapiens

<400>  129
ccgcagagtg tgactcctgt tctgtgtatg gcactggtag aattcactgt gaacagtctc       60

agtcagtgaa ttaccgaagg gccataaaca gagcagagac agatccacga                 110


<210>  130
<211>  550
<212>  PRT
<213>  homo sapiens

<400>  130

Met Pro Pro Pro Arg Thr Gly Arg Gly Leu Leu Trp Leu Gly Leu Val 
1               5                   10                  15      


Leu Ser Ser Val Cys Val Ala Leu Gly Ser Glu Thr Gln Ala Asn Ser 
            20                  25                  30          


Thr Thr Asp Ala Leu Asn Val Leu Leu Ile Ile Val Asp Asp Leu Arg 
        35                  40                  45              


Pro Ser Leu Gly Cys Tyr Gly Asp Lys Leu Val Arg Ser Pro Asn Ile 
    50                  55                  60                  


Asp Gln Leu Ala Ser His Ser Leu Leu Phe Gln Asn Ala Phe Ala Gln 
65                  70                  75                  80  


Gln Ala Val Cys Ala Pro Ser Arg Val Ser Phe Leu Thr Gly Arg Arg 
                85                  90                  95      


Pro Asp Thr Thr Arg Leu Tyr Asp Phe Asn Ser Tyr Trp Arg Val His 
            100                 105                 110         


Ala Gly Asn Phe Ser Thr Ile Pro Gln Tyr Phe Lys Glu Asn Gly Tyr 
        115                 120                 125             


Val Thr Met Ser Val Gly Lys Val Phe His Pro Gly Ile Ser Ser Asn 
    130                 135                 140                 


His Thr Asp Asp Ser Pro Tyr Ser Trp Ser Phe Pro Pro Tyr His Pro 
145                 150                 155                 160 


Ser Ser Glu Lys Tyr Glu Asn Thr Lys Thr Cys Arg Gly Pro Asp Gly 
                165                 170                 175     


Glu Leu His Ala Asn Leu Leu Cys Pro Val Asp Val Leu Asp Val Pro 
            180                 185                 190         


Glu Gly Thr Leu Pro Asp Lys Gln Ser Thr Glu Gln Ala Ile Gln Leu 
        195                 200                 205             


Leu Glu Lys Met Lys Thr Ser Ala Ser Pro Phe Phe Leu Ala Val Gly 
    210                 215                 220                 


Tyr His Lys Pro His Ile Pro Phe Arg Tyr Pro Lys Glu Phe Gln Lys 
225                 230                 235                 240 


Leu Tyr Pro Leu Glu Asn Ile Thr Leu Ala Pro Asp Pro Glu Val Pro 
                245                 250                 255     


Asp Gly Leu Pro Pro Val Ala Tyr Asn Pro Trp Met Asp Ile Arg Gln 
            260                 265                 270         


Arg Glu Asp Val Gln Ala Leu Asn Ile Ser Val Pro Tyr Gly Pro Ile 
        275                 280                 285             


Pro Val Asp Phe Gln Arg Lys Ile Arg Gln Ser Tyr Phe Ala Ser Val 
    290                 295                 300                 


Ser Tyr Leu Asp Thr Gln Val Gly Arg Leu Leu Ser Ala Leu Asp Asp 
305                 310                 315                 320 


Leu Gln Leu Ala Asn Ser Thr Ile Ile Ala Phe Thr Ser Asp His Gly 
                325                 330                 335     


Trp Ala Leu Gly Glu His Gly Glu Trp Ala Lys Tyr Ser Asn Phe Asp 
            340                 345                 350         


Val Ala Thr His Val Pro Leu Ile Phe Tyr Val Pro Gly Arg Thr Ala 
        355                 360                 365             


Ser Leu Pro Glu Ala Gly Glu Lys Leu Phe Pro Tyr Leu Asp Pro Phe 
    370                 375                 380                 


Asp Ser Ala Ser Gln Leu Met Glu Pro Gly Arg Gln Ser Met Asp Leu 
385                 390                 395                 400 


Val Glu Leu Val Ser Leu Phe Pro Thr Leu Ala Gly Leu Ala Gly Leu 
                405                 410                 415     


Gln Val Pro Pro Arg Cys Pro Val Pro Ser Phe His Val Glu Leu Cys 
            420                 425                 430         


Arg Glu Gly Lys Asn Leu Leu Lys His Phe Arg Phe Arg Asp Leu Glu 
        435                 440                 445             


Glu Asp Pro Tyr Leu Pro Gly Asn Pro Arg Glu Leu Ile Ala Tyr Ser 
    450                 455                 460                 


Gln Tyr Pro Arg Pro Ser Asp Ile Pro Gln Trp Asn Ser Asp Lys Pro 
465                 470                 475                 480 


Ser Leu Lys Asp Ile Lys Ile Met Gly Tyr Ser Ile Arg Thr Ile Asp 
                485                 490                 495     


Tyr Arg Tyr Thr Val Trp Val Gly Phe Asn Pro Asp Glu Phe Leu Ala 
            500                 505                 510         


Asn Phe Ser Asp Ile His Ala Gly Glu Leu Tyr Phe Val Asp Ser Asp 
        515                 520                 525             


Pro Leu Gln Asp His Asn Met Tyr Asn Asp Ser Gln Gly Gly Asp Leu 
    530                 535                 540                 


Phe Gln Leu Leu Met Pro 
545                 550 


<210>  131
<211>  11
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthesized

<400>  131

Ala Gln Leu Asn Thr Thr Lys Pro Tyr Glu Ser 
1               5                   10      


<210>  132
<211>  11
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthesized

<400>  132

Ala Gln Leu Asn Thr Thr Lys Pro Leu Val Gln 
1               5                   10      


<210>  133
<211>  11
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthesized

<400>  133

Ala Gln Leu Asn Thr Thr Lys Gln Leu Asp Gln 
1               5                   10      


<210>  134
<211>  11
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthesized

<400>  134

Ala Gln Leu Asn Thr Thr Lys Pro Ser Asp Arg 
1               5                   10      


<210>  135
<211>  11
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthesized

<400>  135

Ala Gln Leu Asn Thr Thr Lys Pro Phe Glu Gln 
1               5                   10      


<210>  136
<211>  11
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthesized

<400>  136

Ala Gln Leu Asn Thr Thr Lys Pro Thr Met Ala 
1               5                   10      


<210>  137
<211>  11
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthesized

<400>  137

Ala Gln Leu Asn Thr Thr Lys Ser Phe Pro Gln 
1               5                   10      


<210>  138
<211>  11
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthesized

<400>  138

Ala Gln Leu Asn Thr Thr Lys Pro Glu Gly Gln 
1               5                   10      


<210>  139
<211>  11
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthesized

<400>  139

Ala Gln Leu Asn Thr Thr Lys Asn Ile Gly Gln 
1               5                   10      


<210>  140
<211>  11
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthesized

<400>  140

Ala Gln Leu Asn Thr Thr Lys Gln Thr Met Gln 
1               5                   10      


<210>  141
<211>  11
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthesized

<400>  141

Ala Gln Leu Asn Thr Thr Lys Thr Ser Asp Gln 
1               5                   10      


<210>  142
<211>  11
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthesized

<400>  142

Glu Leu Lys Asn Thr Thr Lys Pro Ile Ala Gln 
1               5                   10      


<210>  143
<211>  11
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthesized

<400>  143

Ala Gln Leu Asn Thr Thr Lys Pro Gly Ile Ile 
1               5                   10      


<210>  144
<211>  11
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthesized

<400>  144

Ala Asn Phe Asn Thr Thr Lys Pro Ile Ala Gln 
1               5                   10      


<210>  145
<211>  11
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthesized

<400>  145

Ala Gln Leu Asn Thr Thr Lys Ala Tyr Thr Gln 
1               5                   10      


<210>  146
<211>  11
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthesized

<400>  146

Ala Gln Leu Asn Thr Thr Lys Pro Thr Ala Thr 
1               5                   10      


<210>  147
<211>  11
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthesized

<400>  147

Ala Gln Leu Asn Thr Thr Lys Val Ala Asn Gln 
1               5                   10      


<210>  148
<211>  11
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthesized

<400>  148

Ala Gln Leu Asn Thr Thr Lys Pro Ala Pro Ala 
1               5                   10      


<210>  149
<211>  11
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthesized

<400>  149

Ala Gln Leu Asn Thr Thr Lys Pro Ser Trp Gln 
1               5                   10      


<210>  150
<211>  11
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthesized

<400>  150

Ala Gln Leu Asn Thr Thr Lys Pro Gly Gly Gln 
1               5                   10      


<210>  151
<211>  11
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthesized

<400>  151

Pro Thr Ser Asn Thr Thr Lys Pro Ile Ala Gln 
1               5                   10      


<210>  152
<211>  11
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthesized

<400>  152

Gln Pro Leu Asn Thr Thr Lys Pro Ile Ala Gln 
1               5                   10      


<210>  153
<211>  11
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthesized

<400>  153

Ala Gln Leu Asn Thr Thr Lys Pro Thr Ile Gly 
1               5                   10      


<210>  154
<211>  11
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthesized

<400>  154

Ala Leu Asn Asn Thr Thr Lys Pro Ile Ala Gln 
1               5                   10      


<210>  155
<211>  11
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthesized

<400>  155

Ala Gln Leu Asn Thr Thr Lys Ala Ile Gln Gln 
1               5                   10      


<210>  156
<211>  11
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthesized

<400>  156

Ala Gln Leu Asn Thr Thr Lys Pro Thr Glu Gln 
1               5                   10      


<210>  157
<211>  11
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthesized

<400>  157

Asp Met Thr Asn Thr Thr Lys Pro Ile Ala Gln 
1               5                   10      


<210>  158
<211>  11
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthesized

<400>  158

Ala Gln Leu Asn Thr Thr Lys Pro Leu Asn Phe 
1               5                   10      


<210>  159
<211>  11
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthesized

<400>  159

Ala Gln Leu Asn Thr Thr Lys Pro Met Ser Gln 
1               5                   10      


<210>  160
<211>  11
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthesized

<400>  160

Ala Gln Leu Asn Thr Thr Lys Ala Val Ser Gln 
1               5                   10      


<210>  161
<211>  11
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthesized

<400>  161

Leu Ala Leu Asn Thr Thr Lys Pro Ile Ala Gln 
1               5                   10      


<210>  162
<211>  11
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthesized

<400>  162

Ala Gln Leu Asn Thr Thr Lys Ala Val Thr Gln 
1               5                   10      


<210>  163
<211>  11
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthesized

<400>  163

Ala Gln Leu Asn Thr Thr Lys Pro Val Asp Trp 
1               5                   10      


<210>  164
<211>  11
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthesized

<400>  164

Ala Gln Leu Asn Thr Thr Lys Pro Gln Asp Gln 
1               5                   10      


<210>  165
<211>  11
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthesized

<400>  165

Glu Val Thr Asn Thr Thr Lys Pro Ile Ala Gln 
1               5                   10      


<210>  166
<211>  11
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthesized

<400>  166

Gln Ile Ser Asn Thr Thr Lys Pro Ile Ala Gln 
1               5                   10      


<210>  167
<211>  11
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthesized

<400>  167

Ala Gln Leu Asn Thr Thr Lys Gln Met Thr Gln 
1               5                   10      


<210>  168
<211>  11
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthesized

<400>  168

Ala Met Gln Asn Thr Thr Lys Pro Ile Ala Gln 
1               5                   10      


<210>  169
<211>  11
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthesized

<400>  169

Ala Gln Leu Asn Thr Thr Lys Pro Val Ser Met 
1               5                   10      


<210>  170
<211>  11
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthesized

<400>  170

Ala Gln Ala Asn Thr Thr Lys Pro Ile Ala Gln 
1               5                   10      


<210>  171
<211>  11
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthesized

<400>  171

Ala Gln Leu Asn Thr Thr Lys Gln Thr Glu Gln 
1               5                   10      


<210>  172
<211>  11
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthesized

<400>  172

Ala Ser Glu Asn Thr Thr Lys Pro Ile Ala Gln 
1               5                   10      


<210>  173
<211>  11
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthesized

<400>  173

Ala Gln Leu Asn Thr Thr Lys Pro Phe Glu Gly 
1               5                   10      


<210>  174
<211>  11
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthesized

<400>  174

Ala Gln Leu Asn Thr Thr Lys Pro Ser Asp His 
1               5                   10      


<210>  175
<211>  11
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthesized

<400>  175

Ala Gln Leu Asn Thr Thr Arg Asn Gln Ala Gln 
1               5                   10      


<210>  176
<211>  11
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthesized

<400>  176

Val Leu Ser Asn Thr Thr Lys Pro Ile Ala Gln 
1               5                   10      


<210>  177
<211>  11
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthesized

<400>  177

Ala Gln Leu Asn Thr Thr Lys Gln Ile Pro Gln 
1               5                   10      


<210>  178
<211>  11
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthesized

<400>  178

Ala Gln Leu Asn Thr Thr Lys Pro Val Ser Asp 
1               5                   10      


<210>  179
<211>  11
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthesized

<400>  179

Ala Gln Leu Asn Thr Thr Lys Pro Thr Met Ser 
1               5                   10      


<210>  180
<211>  11
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthesized

<400>  180

Ala Gln Leu Asn Thr Thr Lys Asn Ser Gln Gln 
1               5                   10      


<210>  181
<211>  11
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthesized

<400>  181

Ala Gln Leu Asn Thr Thr Lys Pro Asp Phe Gly 
1               5                   10      


<210>  182
<211>  11
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthesized

<400>  182

Ala Gln Leu Asn Thr Thr Lys Pro Val Gly Tyr 
1               5                   10      


<210>  183
<211>  11
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthesized

<400>  183

Ala Gln Ser Asn Thr Thr Lys Pro Ile Ala Gln 
1               5                   10      


<210>  184
<211>  11
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthesized

<400>  184

Ala Ser Val Asn Thr Thr Lys Pro Ile Ala Gln 
1               5                   10      


<210>  185
<211>  11
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthesized

<400>  185

Ala Gln Leu Asn Thr Thr Lys Leu Thr Gln Gln 
1               5                   10      


<210>  186
<211>  11
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthesized

<400>  186

Val Ser Ser Asn Thr Thr Lys Pro Ile Ala Gln 
1               5                   10      


<210>  187
<211>  11
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthesized

<400>  187

Ala Gln Leu Asn Thr Thr Lys Pro Phe Ala Gln 
1               5                   10      


<210>  188
<211>  11
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthesized

<400>  188

Ala Val Met Asn Thr Thr Lys Pro Ile Ala Gln 
1               5                   10      


<210>  189
<211>  11
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthesized

<400>  189

Ala Ile Glu Asn Thr Thr Lys Pro Ile Ala Gln 
1               5                   10      


<210>  190
<211>  11
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthesized

<400>  190

Ala Gln Leu Asn Thr Thr Lys Leu His Glu Gln 
1               5                   10      


<210>  191
<211>  11
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthesized

<400>  191

Ala Gln Leu Asn Thr Thr Lys Pro Asp Asn Asn 
1               5                   10      


<210>  192
<211>  11
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthesized

<400>  192

Ala Gln Leu Asn Thr Thr Lys Pro Gln Pro Val 
1               5                   10      


<210>  193
<211>  11
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthesized

<400>  193

Pro Gly Leu Asn Thr Thr Lys Pro Ile Ala Gln 
1               5                   10      


<210>  194
<211>  11
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthesized

<400>  194

Ala Gln Leu Asn Thr Thr Lys Gln Ile Ala Gln 
1               5                   10      


<210>  195
<211>  11
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthesized

<400>  195

Glu Thr Ser Asn Thr Thr Lys Pro Ile Ala Gln 
1               5                   10      


<210>  196
<211>  11
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthesized

<400>  196

Ala Gln Leu Asn Thr Thr Lys Pro Met Asp Gln 
1               5                   10      


<210>  197
<211>  11
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthesized

<400>  197

Ala Gln Leu Asn Thr Thr Lys Pro Ser Leu Asp 
1               5                   10      


<210>  198
<211>  11
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthesized

<400>  198

Ala Gln Leu Asn Thr Thr Lys Thr Phe Glu Gln 
1               5                   10      


<210>  199
<211>  11
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthesized

<400>  199

Thr Thr Asn Asn Thr Thr Lys Pro Ile Ala Gln 
1               5                   10      


