                         SEQUENCE LISTING

<110>  President and Fellows of Harvard College
 
<120>  E3 LIGASE BINDERS AND USES THEREOF

<130>  H0824.70375WO00

<140>  Not Yet Assigned
<141>  2022-04-13

<150>  US 63/303,364
<151>  2022-01-26

<150>  US 63/174,389
<151>  2021-04-13

<160>  63    

<170>  PatentIn version 3.5

<210>  1
<211>  17
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic


<220>
<221>  MOD_RES
<222>  (17)..(17)
<223>  aspartimide

<400>  1

Phe Phe Glu Ser Phe Gly Asp Leu Ser Thr Pro Asp Ala Val Met Gly 
1               5                   10                  15      


Asn 
    


<210>  2
<211>  4
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic

<400>  2

Cys Lys Gln Cys 
1               


<210>  3
<211>  9
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic

<400>  3

His Ser Trp Phe Pro Gly Tyr Ala Trp 
1               5                   


<210>  4
<211>  4
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic

<400>  4

Cys Lys Ile Cys 
1               


<210>  5
<211>  5
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic

<400>  5

Leu Pro Glu Thr Gly 
1               5   


<210>  6
<211>  8
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic


<220>
<221>  MISC_FEATURE
<222>  (8)..(8)
<223>  Xaa may be FcQMe, FcQ, FcN, FQ, FN

<400>  6

Leu Pro Glu Thr Gly Gly Gly Xaa 
1               5               


<210>  7
<211>  8
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic


<220>
<221>  MISC_FEATURE
<222>  (8)..(8)
<223>  Xaa may be FcQ, FcN, FQMe

<400>  7

Leu Pro Glu Thr Gly Gly Gly Xaa 
1               5               


<210>  8
<211>  5
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic


<220>
<221>  MOD_RES
<222>  (5)..(5)
<223>  glutarimide

<400>  8

Gly Gly Gly Phe Gln 
1               5   


<210>  9
<211>  5
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic


<220>
<221>  MOD_RES
<222>  (5)..(5)
<223>  aspartimide

<400>  9

Gly Gly Gly Phe Asn 
1               5   


<210>  10
<211>  17
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic


<220>
<221>  MOD_RES
<222>  (17)..(17)
<223>  aspartimide

<400>  10

Val Ala Asp Ala Leu Thr Asn Ala Val Ala His Val Asp Asp Met Pro 
1               5                   10                  15      


Asn 
    


<210>  11
<211>  14
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic


<220>
<221>  MOD_RES
<222>  (14)..(14)
<223>  aspartimide

<400>  11

Val Leu Gly Ala Phe Ser Asp Gly Leu Ala His Leu Asp Asn 
1               5                   10                  


<210>  12
<211>  9
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic


<220>
<221>  MOD_RES
<222>  (9)..(9)
<223>  cyclic imide modified alanine

<400>  12

Lys Lys Val Ala Asp Ala Leu Thr Ala 
1               5                   


<210>  13
<211>  8
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic


<220>
<221>  MOD_RES
<222>  (8)..(8)
<223>  cyclic imide modified alanine

<400>  13

Lys Val Ala Asp Ala Leu Thr Ala 
1               5               


<210>  14
<211>  19
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic


<220>
<221>  MOD_RES
<222>  (19)..(19)
<223>  cyclic imide modified alanine

<400>  14

Lys Lys Val Ala Asp Ala Leu Thr Asn Ala Val Ala His Val Asp Asp 
1               5                   10                  15      


Met Pro Ala 
            


<210>  15
<211>  18
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic


<220>
<221>  MOD_RES
<222>  (18)..(18)
<223>  cyclic imide modified alanine

<400>  15

Lys Val Ala Asp Ala Leu Thr Asn Ala Val Ala His Val Asp Asp Met 
1               5                   10                  15      


Pro Ala 
        


<210>  16
<211>  15
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic


<220>
<221>  MOD_RES
<222>  (15)..(15)
<223>  cyclic imide modified valine

<400>  16

Lys Thr Tyr Phe Pro His Phe Asp Leu Ser His Gly Ser Ala Val 
1               5                   10                  15  


<210>  17
<211>  18
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic


<220>
<221>  MOD_RES
<222>  (18)..(18)
<223>  cyclic imide modified proline

<400>  17

Arg Phe Phe Glu Ser Phe Gly Asp Leu Ser Thr Pro Asp Ala Val Met 
1               5                   10                  15      


Gly Pro 
        


<210>  18
<211>  8
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic


<220>
<221>  MOD_RES
<222>  (8)..(8)
<223>  cyclic imide modified alanine

<400>  18

Lys Glu Phe Thr Pro Pro Val Ala 
1               5               


<210>  19
<211>  12
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic


<220>
<221>  MOD_RES
<222>  (12)..(12)
<223>  cyclic imide modified lysine

<400>  19

Lys Glu Phe Thr Pro Pro Val Gln Ala Ala Tyr Lys 
1               5                   10          


<210>  20
<211>  15
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic


<220>
<221>  MOD_RES
<222>  (15)..(15)
<223>  cyclic imide modified lysine

<400>  20

Lys Val Leu Gly Ala Phe Ser Asp Gly Leu Ala His Leu Asp Lys 
1               5                   10                  15  


<210>  21
<211>  142
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic


<220>
<221>  MOD_RES
<222>  (55)..(55)
<223>  glutarimide

<220>
<221>  MOD_RES
<222>  (69)..(69)
<223>  aspartimide

<220>
<221>  MOD_RES
<222>  (79)..(79)
<223>  aspartimide

<400>  21

Met Val Leu Ser Pro Ala Asp Lys Thr Asn Val Lys Ala Ala Trp Gly 
1               5                   10                  15      


Lys Val Gly Ala His Ala Gly Glu Tyr Gly Ala Glu Ala Leu Glu Arg 
            20                  25                  30          


Met Phe Leu Ser Phe Pro Thr Thr Lys Thr Tyr Phe Pro His Phe Asp 
        35                  40                  45              


Leu Ser His Gly Ser Ala Gln Val Lys Gly His Gly Lys Lys Val Ala 
    50                  55                  60                  


Asp Ala Leu Thr Asn Ala Val Ala His Val Asp Asp Met Pro Asn Ala 
65                  70                  75                  80  


Leu Ser Ala Leu Ser Asp Leu His Ala His Lys Leu Arg Val Asp Pro 
                85                  90                  95      


Val Asn Phe Lys Leu Leu Ser His Cys Leu Leu Val Thr Leu Ala Ala 
            100                 105                 110         


His Leu Pro Ala Glu Phe Thr Pro Ala Val His Ala Ser Leu Asp Lys 
        115                 120                 125             


Phe Leu Ala Ser Val Ser Thr Val Leu Thr Ser Lys Tyr Arg 
    130                 135                 140         


<210>  22
<211>  147
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic


<220>
<221>  MOD_RES
<222>  (58)..(58)
<223>  aspartimide

<220>
<221>  MOD_RES
<222>  (81)..(81)
<223>  aspartimide

<220>
<221>  MOD_RES
<222>  (128)..(128)
<223>  glutarimide

<220>
<221>  MOD_RES
<222>  (132)..(132)
<223>  glutarimide

<400>  22

Met Val His Leu Thr Pro Glu Glu Lys Ser Ala Val Thr Ala Leu Trp 
1               5                   10                  15      


Gly Lys Val Asn Val Asp Glu Val Gly Gly Glu Ala Leu Gly Arg Leu 
            20                  25                  30          


Leu Val Val Tyr Pro Trp Thr Gln Arg Phe Phe Glu Ser Phe Gly Asp 
        35                  40                  45              


Leu Ser Thr Pro Asp Ala Val Met Gly Asn Pro Lys Val Lys Ala His 
    50                  55                  60                  


Gly Lys Lys Val Leu Gly Ala Phe Ser Asp Gly Leu Ala His Leu Asp 
65                  70                  75                  80  


Asn Leu Lys Gly Thr Phe Ala Thr Leu Ser Glu Leu His Cys Asp Lys 
                85                  90                  95      


Leu His Val Asp Pro Glu Asn Phe Arg Leu Leu Gly Asn Val Leu Val 
            100                 105                 110         


Cys Val Leu Ala His His Phe Gly Lys Glu Phe Thr Pro Pro Val Gln 
        115                 120                 125             


Ala Ala Tyr Gln Lys Val Val Ala Gly Val Ala Asn Ala Leu Ala His 
    130                 135                 140                 


Lys Tyr His 
145         


<210>  23
<211>  19
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic

<400>  23

Phe Phe Glu Ser Phe Gly Asp Leu Ser Thr Pro Asp Ala Val Met Gly 
1               5                   10                  15      


Asn Pro Lys 
            


<210>  24
<211>  15
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic

<400>  24

Val Leu Gly Ala Phe Ser Asp Gly Leu Ala His Leu Asp Leu Lys 
1               5                   10                  15  


<210>  25
<211>  9
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic


<220>
<221>  MOD_RES
<222>  (8)..(8)
<223>  aspartimide

<400>  25

Lys Val Ala Asp Ala Leu Thr Asn Ala 
1               5                   


<210>  26
<211>  19
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic


<220>
<221>  MOD_RES
<222>  (18)..(18)
<223>  aspartimide

<400>  26

Lys Val Ala Asp Ala Leu Thr Asn Ala Val Ala His Val Asp Asp Met 
1               5                   10                  15      


Pro Asn Ala 
            


<210>  27
<211>  16
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic


<220>
<221>  MOD_RES
<222>  (15)..(15)
<223>  glutarimide

<400>  27

Lys Thr Tyr Phe Pro His Phe Asp Leu Ser His Gly Ser Ala Gln Val 
1               5                   10                  15      


<210>  28
<211>  19
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic


<220>
<221>  MOD_RES
<222>  (18)..(18)
<223>  aspartimide

<400>  28

Arg Phe Phe Glu Ser Phe Gly Asp Leu Ser Thr Pro Asp Ala Val Met 
1               5                   10                  15      


Gly Asn Pro 
            


<210>  29
<211>  16
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic


<220>
<221>  MOD_RES
<222>  (15)..(15)
<223>  aspartimide

<400>  29

Lys Val Leu Gly Ala Phe Ser Asp Gly Leu Ala His Leu Asp Asn Leu 
1               5                   10                  15      


<210>  30
<211>  9
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic


<220>
<221>  MOD_RES
<222>  (8)..(8)
<223>  glutarimide

<400>  30

Lys Glu Phe Thr Pro Pro Val Gln Ala 
1               5                   


<210>  31
<211>  13
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic


<220>
<221>  MOD_RES
<222>  (12)..(12)
<223>  glutarimide

<400>  31

Lys Glu Phe Thr Pro Pro Val Gln Ala Ala Tyr Gln Lys 
1               5                   10              


<210>  32
<211>  18
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic


<220>
<221>  MOD_RES
<222>  (17)..(17)
<223>  aspartimide

<400>  32

Arg Val Ala Pro Glu Glu His Pro Val Leu Leu Thr Glu Ala Pro Leu 
1               5                   10                  15      


Asn Pro 
        


<210>  33
<211>  5
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic


<220>
<221>  MOD_RES
<222>  (5)..(5)
<223>  glutarimide

<400>  33

Gly Gly Gly Leu Gln 
1               5   


<210>  34
<211>  23
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic

<400>  34

Phe Phe Glu Ser Phe Phe Glu Ser Phe Gly Asp Leu Ser Thr Pro Asp 
1               5                   10                  15      


Ala Val Met Gly Asn Pro Lys 
            20              


<210>  35
<211>  21
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic


<220>
<221>  MOD_RES
<222>  (21)..(21)
<223>  aspartimide

<400>  35

Phe Phe Glu Ser Phe Phe Glu Ser Phe Gly Asp Leu Ser Thr Pro Asp 
1               5                   10                  15      


Ala Val Met Gly Asn 
            20      


<210>  36
<211>  21
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic

<400>  36

Phe Phe Glu Ser Phe Phe Glu Ser Phe Gly Asp Leu Ser Thr Pro Asp 
1               5                   10                  15      


Ala Val Met Gly Asn 
            20      


<210>  37
<211>  18
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic

<400>  37

Val Ala Pro Glu Glu His Pro Val Leu Leu Thr Glu Ala Pro Leu Asn 
1               5                   10                  15      


Pro Lys 
        


<210>  38
<211>  16
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic


<220>
<221>  MOD_RES
<222>  (16)..(16)
<223>  aspartimide

<400>  38

Val Ala Pro Glu Glu His Pro Val Leu Leu Thr Glu Ala Pro Leu Asn 
1               5                   10                  15      


<210>  39
<211>  16
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic

<400>  39

Val Ala Pro Glu Glu His Pro Val Leu Leu Thr Glu Ala Pro Leu Asn 
1               5                   10                  15      


<210>  40
<211>  29
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic

<400>  40

Val Ala Asp Ala Leu Thr Asn Ala Val Ala His Val Asp Asp Met Pro 
1               5                   10                  15      


Asn Ala Leu Ser Ala Leu Ser Asp Leu His Ala His Lys 
            20                  25                  


<210>  41
<211>  17
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic

<400>  41

Val Ala Asp Ala Leu Thr Asn Ala Val Ala His Val Asp Asp Met Pro 
1               5                   10                  15      


Asn 
    


<210>  42
<211>  7
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic


<220>
<221>  MOD_RES
<222>  (7)..(7)
<223>  aspartimide

<400>  42

Val Ala Asp Ala Leu Thr Asn 
1               5           


<210>  43
<211>  7
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic

<400>  43

Val Ala Asp Ala Leu Thr Asn 
1               5           


<210>  44
<211>  19
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic

<400>  44

Phe Phe Glu Ser Phe Gly Asp Leu Ser Thr Pro Asp Ala Val Met Gly 
1               5                   10                  15      


Asn Pro Lys 
            


<210>  45
<211>  18
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Synthetic

<400>  45
caccaccacc accaccac                                                     18


<210>  46
<211>  47
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Synthetic

<400>  46
accggtttcc gggaggctac caccggtctt gtacagctcg tccatgc                     47


<210>  47
<211>  29
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Synthetic

<400>  47
ggcggcagcg gagtgcaggt ggaaaccat                                         29


<210>  48
<211>  20
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Synthetic

<400>  48
ttttggagga tggtcgccac                                                   20


<210>  49
<211>  49
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Synthetic

<400>  49
ggccaccatc accatcacca ctaaactaga attcatcgtg actgactga                   49


<210>  50
<211>  50
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Synthetic

<400>  50
gcccgtctca ggtaacgagc ctccagtcag atcctcttct gagatgagtt                  50


<210>  51
<211>  21
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Synthetic

<400>  51
catgtacgtt gctatccagg c                                                 21


<210>  52
<211>  21
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Synthetic

<400>  52
ctccttaatg tcacgcacga t                                                 21


<210>  53
<211>  21
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Synthetic

<400>  53
aatggcacaa acgctggaaa a                                                 21


<210>  54
<211>  19
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Synthetic

<400>  54
cactggtaac actgccctg                                                    19


<210>  55
<211>  21
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Synthetic

<400>  55
gagctaccca cagaagaaac c                                                 21


<210>  56
<211>  22
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Synthetic

<400>  56
gagtcgatgc ttgagttgtg tt                                                22


<210>  57
<211>  21
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Synthetic

<400>  57
ttccgtgatc cttttgagtg c                                                 21


<210>  58
<211>  19
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Synthetic

<400>  58
ctcgcgttat gtgcgacga                                                    19


<210>  59
<211>  9
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic

<400>  59

Thr Gly Gly Ser Leu Pro Glu Thr Gly 
1               5                   


<210>  60
<211>  5
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic


<220>
<221>  MOD_RES
<222>  (5)..(5)
<223>  methylated glutarimide

<400>  60

Gly Gly Gly Phe Gln 
1               5   


<210>  61
<211>  5
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic


<220>
<221>  MOD_RES
<222>  (5)..(5)
<223>  glutarimide

<400>  61

Gly Gly Gly Pro Gln 
1               5   


<210>  62
<211>  5
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic


<220>
<221>  MOD_RES
<222>  (5)..(5)
<223>  aspartimide

<400>  62

Gly Gly Gly Leu Asn 
1               5   


<210>  63
<211>  5
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic


<220>
<221>  MOD_RES
<222>  (5)..(5)
<223>  any cyclized amino acid

<220>
<221>  MOD_RES
<222>  (5)..(5)
<223>  Xaa is any cyclized amino acid

<400>  63

Gly Gly Gly Phe Xaa 
1               5   


