                         SEQUENCE LISTING

<110>  Villaris Therapeutics, Inc.
 
<120>  ANTI-CD122 ANTIBODIES AND USES THEREOF

<130>  VLRS-001/02WO 338855-2003

<150>  US 63/279,762
<151>  2021-11-16

<150>  US 63/174,772
<151>  2021-04-14

<160>  163   

<170>  PatentIn version 3.5

<210>  1
<211>  119
<212>  PRT
<213>  Artificial Sequence

<220>  
<223>  heavy chain variable region

<400>  1

Glu Val Gln Leu Leu Glu Ser Gly Gly Gly Leu Val Gln Pro Gly Gly 
1               5                   10                  15      


Ser Leu Arg Leu Ser Cys Ala Ala Ser Gly Phe Thr Val Thr Ser Tyr 
            20                  25                  30          


Ala Val His Trp Val Arg Gln Ala Pro Gly Lys Gly Leu Glu Trp Leu 
        35                  40                  45              


Gly Val Ile Trp Ser Gly Gly Ser Thr Asp Tyr Asn Ala Ala Phe Ile 
    50                  55                  60                  


Ser Arg Leu Thr Ile Ser Lys Asp Asn Ser Lys Asn Thr Val Tyr Phe 
65                  70                  75                  80  


Gln Met Asn Ser Leu Arg Ala Glu Asp Thr Ala Val Tyr Tyr Cys Ala 
                85                  90                  95      


Arg Ala Gly Asp Ala Asn Tyr Asp Gly Phe Ala Tyr Trp Gly Gln Gly 
            100                 105                 110         


Thr Leu Val Thr Val Ser Ser 
        115                 


<210>  2
<211>  30
<212>  PRT
<213>  Artificial Sequence

<220>  
<223>  heavy chain FR1

<400>  2

Glu Val Gln Leu Leu Glu Ser Gly Gly Gly Leu Val Gln Pro Gly Gly 
1               5                   10                  15      


Ser Leu Arg Leu Ser Cys Ala Ala Ser Gly Phe Thr Val Thr 
            20                  25                  30  


<210>  3
<211>  5
<212>  PRT
<213>  Artificial Sequence

<220>  
<223>  anti-CD122 HCDR1

<400>  3

Ser Tyr Ala Val His 
1               5   


<210>  4
<211>  14
<212>  PRT
<213>  Artificial Sequence

<220>  
<223>  heavy chain FR2

<400>  4

Trp Val Arg Gln Ala Pro Gly Lys Gly Leu Glu Trp Leu Gly 
1               5                   10                  


<210>  5
<211>  16
<212>  PRT
<213>  Mus musculus

<400>  5

Val Ile Trp Ser Gly Gly Ser Thr Asp Tyr Asn Ala Ala Phe Ile Ser 
1               5                   10                  15      


<210>  6
<211>  32
<212>  PRT
<213>  Artificial Sequence

<220>  
<223>  heavy chain FR3

<400>  6

Arg Leu Thr Ile Ser Lys Asp Asn Ser Lys Asn Thr Val Tyr Phe Gln 
1               5                   10                  15      


Met Asn Ser Leu Arg Ala Glu Asp Thr Ala Val Tyr Tyr Cys Ala Arg 
            20                  25                  30          


<210>  7
<211>  11
<212>  PRT
<213>  Artificial Sequence

<220>  
<223>  HCDR3

<400>  7

Ala Gly Asp Ala Asn Tyr Asp Gly Phe Ala Tyr 
1               5                   10      


<210>  8
<211>  11
<212>  PRT
<213>  Artificial Sequence

<220>  
<223>  heavy chain FR4

<400>  8

Trp Gly Gln Gly Thr Leu Val Thr Val Ser Ser 
1               5                   10      


<210>  9
<211>  106
<212>  PRT
<213>  Artificial Sequence

<220>  
<223>  light chain variable region

<400>  9

Asp Ile Gln Met Thr Gln Ser Pro Ser Ser Leu Ser Ala Ser Val Gly 
1               5                   10                  15      


Asp Arg Val Thr Ile Thr Cys Gln Ala Ser Gln Ser Val Ser Phe Leu 
            20                  25                  30          


Tyr Trp Tyr Gln Gln Arg Pro Gly Lys Ala Pro Arg Leu Leu Ile Tyr 
        35                  40                  45              


Asp Thr Ser Asn Leu Ala Ser Gly Val Pro Ser Arg Phe Ser Gly Ser 
    50                  55                  60                  


Gly Ser Gly Thr Ser Tyr Thr Phe Thr Ile Ser Ser Leu Gln Pro Glu 
65                  70                  75                  80  


Asp Ile Ala Thr Tyr Tyr Cys Gln Gln Trp Ser Thr Tyr Pro Leu Thr 
                85                  90                  95      


Phe Gly Gln Gly Thr Lys Val Glu Ile Lys 
            100                 105     


<210>  10
<211>  23
<212>  PRT
<213>  Artificial Sequence

<220>  
<223>  light chain FR1

<400>  10

Asp Ile Gln Met Thr Gln Ser Pro Ser Ser Leu Ser Ala Ser Val Gly 
1               5                   10                  15      


Asp Arg Val Thr Ile Thr Cys 
            20              


<210>  11
<211>  10
<212>  PRT
<213>  Artificial Sequence

<220>  
<223>  LCDR1

<400>  11

Gln Ala Ser Gln Ser Val Ser Phe Leu Tyr 
1               5                   10  


<210>  12
<211>  15
<212>  PRT
<213>  Artificial Sequence

<220>  
<223>  light chain FR2

<400>  12

Trp Tyr Gln Gln Arg Pro Gly Lys Ala Pro Arg Leu Leu Ile Tyr 
1               5                   10                  15  


<210>  13
<211>  7
<212>  PRT
<213>  Mus musculus

<400>  13

Asp Thr Ser Asn Leu Ala Ser 
1               5           


<210>  14
<211>  32
<212>  PRT
<213>  Artificial Sequence

<220>  
<223>  light chain FR3

<400>  14

Gly Val Pro Ser Arg Phe Ser Gly Ser Gly Ser Gly Thr Ser Tyr Thr 
1               5                   10                  15      


Phe Thr Ile Ser Ser Leu Gln Pro Glu Asp Ile Ala Thr Tyr Tyr Cys 
            20                  25                  30          


<210>  15
<211>  9
<212>  PRT
<213>  Mus musculus

<400>  15

Gln Gln Trp Ser Thr Tyr Pro Leu Thr 
1               5                   


<210>  16
<211>  10
<212>  PRT
<213>  Artificial Sequence

<220>  
<223>  light chain FR4

<400>  16

Phe Gly Gln Gly Thr Lys Val Glu Ile Lys 
1               5                   10  


<210>  17
<211>  106
<212>  PRT
<213>  Artificial Sequence

<220>  
<223>  light chain variable region

<400>  17

Asp Ile Gln Met Thr Gln Ser Pro Ser Ser Leu Ser Ala Ser Val Gly 
1               5                   10                  15      


Asp Arg Val Thr Ile Thr Cys Gln Ala Ser Ser Ser Val Ser Phe Met 
            20                  25                  30          


Tyr Trp Tyr Gln Gln Arg Pro Gly Lys Ala Pro Arg Leu Leu Ile Tyr 
        35                  40                  45              


Asp Thr Ser Asn Leu Ala Ser Gly Val Pro Ser Arg Phe Ser Gly Ser 
    50                  55                  60                  


Gly Ser Gly Thr Ser Tyr Thr Phe Thr Ile Ser Ser Leu Gln Pro Glu 
65                  70                  75                  80  


Asp Ile Ala Thr Tyr Tyr Cys Gln Gln Trp Ser Thr Tyr Pro Leu Thr 
                85                  90                  95      


Phe Gly Gln Gly Thr Lys Val Glu Ile Lys 
            100                 105     


<210>  18
<211>  10
<212>  PRT
<213>  Artificial Sequence

<220>  
<223>  LCDR1

<400>  18

Gln Ala Ser Ser Ser Val Ser Phe Met Tyr 
1               5                   10  


<210>  19
<211>  551
<212>  PRT
<213>  Homo sapiens

<400>  19

Met Ala Ala Pro Ala Leu Ser Trp Arg Leu Pro Leu Leu Ile Leu Leu 
1               5                   10                  15      


Leu Pro Leu Ala Thr Ser Trp Ala Ser Ala Ala Val Asn Gly Thr Ser 
            20                  25                  30          


Gln Phe Thr Cys Phe Tyr Asn Ser Arg Ala Asn Ile Ser Cys Val Trp 
        35                  40                  45              


Ser Gln Asp Gly Ala Leu Gln Asp Thr Ser Cys Gln Val His Ala Trp 
    50                  55                  60                  


Pro Asp Arg Arg Arg Trp Asn Gln Thr Cys Glu Leu Leu Pro Val Ser 
65                  70                  75                  80  


Gln Ala Ser Trp Ala Cys Asn Leu Ile Leu Gly Ala Pro Asp Ser Gln 
                85                  90                  95      


Lys Leu Thr Thr Val Asp Ile Val Thr Leu Arg Val Leu Cys Arg Glu 
            100                 105                 110         


Gly Val Arg Trp Arg Val Met Ala Ile Gln Asp Phe Lys Pro Phe Glu 
        115                 120                 125             


Asn Leu Arg Leu Met Ala Pro Ile Ser Leu Gln Val Val His Val Glu 
    130                 135                 140                 


Thr His Arg Cys Asn Ile Ser Trp Glu Ile Ser Gln Ala Ser His Tyr 
145                 150                 155                 160 


Phe Glu Arg His Leu Glu Phe Glu Ala Arg Thr Leu Ser Pro Gly His 
                165                 170                 175     


Thr Trp Glu Glu Ala Pro Leu Leu Thr Leu Lys Gln Lys Gln Glu Trp 
            180                 185                 190         


Ile Cys Leu Glu Thr Leu Thr Pro Asp Thr Gln Tyr Glu Phe Gln Val 
        195                 200                 205             


Arg Val Lys Pro Leu Gln Gly Glu Phe Thr Thr Trp Ser Pro Trp Ser 
    210                 215                 220                 


Gln Pro Leu Ala Phe Arg Thr Lys Pro Ala Ala Leu Gly Lys Asp Thr 
225                 230                 235                 240 


Ile Pro Trp Leu Gly His Leu Leu Val Gly Leu Ser Gly Ala Phe Gly 
                245                 250                 255     


Phe Ile Ile Leu Val Tyr Leu Leu Ile Asn Cys Arg Asn Thr Gly Pro 
            260                 265                 270         


Trp Leu Lys Lys Val Leu Lys Cys Asn Thr Pro Asp Pro Ser Lys Phe 
        275                 280                 285             


Phe Ser Gln Leu Ser Ser Glu His Gly Gly Asp Val Gln Lys Trp Leu 
    290                 295                 300                 


Ser Ser Pro Phe Pro Ser Ser Ser Phe Ser Pro Gly Gly Leu Ala Pro 
305                 310                 315                 320 


Glu Ile Ser Pro Leu Glu Val Leu Glu Arg Asp Lys Val Thr Gln Leu 
                325                 330                 335     


Leu Leu Gln Gln Asp Lys Val Pro Glu Pro Ala Ser Leu Ser Ser Asn 
            340                 345                 350         


His Ser Leu Thr Ser Cys Phe Thr Asn Gln Gly Tyr Phe Phe Phe His 
        355                 360                 365             


Leu Pro Asp Ala Leu Glu Ile Glu Ala Cys Gln Val Tyr Phe Thr Tyr 
    370                 375                 380                 


Asp Pro Tyr Ser Glu Glu Asp Pro Asp Glu Gly Val Ala Gly Ala Pro 
385                 390                 395                 400 


Thr Gly Ser Ser Pro Gln Pro Leu Gln Pro Leu Ser Gly Glu Asp Asp 
                405                 410                 415     


Ala Tyr Cys Thr Phe Pro Ser Arg Asp Asp Leu Leu Leu Phe Ser Pro 
            420                 425                 430         


Ser Leu Leu Gly Gly Pro Ser Pro Pro Ser Thr Ala Pro Gly Gly Ser 
        435                 440                 445             


Gly Ala Gly Glu Glu Arg Met Pro Pro Ser Leu Gln Glu Arg Val Pro 
    450                 455                 460                 


Arg Asp Trp Asp Pro Gln Pro Leu Gly Pro Pro Thr Pro Gly Val Pro 
465                 470                 475                 480 


Asp Leu Val Asp Phe Gln Pro Pro Pro Glu Leu Val Leu Arg Glu Ala 
                485                 490                 495     


Gly Glu Glu Val Pro Asp Ala Gly Pro Arg Glu Gly Val Ser Phe Pro 
            500                 505                 510         


Trp Ser Arg Pro Pro Gly Gln Gly Glu Phe Arg Ala Leu Asn Ala Arg 
        515                 520                 525             


Leu Pro Leu Asn Thr Asp Ala Tyr Leu Ser Leu Gln Glu Leu Gln Gly 
    530                 535                 540                 


Gln Asp Pro Thr His Leu Val 
545                 550     


<210>  20
<211>  551
<212>  PRT
<213>  Macaca fascicularis

<400>  20

Met Ala Thr Leu Ala Leu Ser Trp Cys Leu Pro Leu Leu Ile Leu Leu 
1               5                   10                  15      


Leu Pro Leu Ala Thr Ser Ser Ala Ser Ala Ala Val Asn Gly Thr Ser 
            20                  25                  30          


Arg Phe Thr Cys Phe Tyr Asn Ser Arg Ala Asn Ile Ser Cys Val Trp 
        35                  40                  45              


Ser Gln Asp Gly Ala Leu Gln Asp Thr Ser Cys Gln Val His Ala Trp 
    50                  55                  60                  


Pro Asp Arg Arg Arg Trp Asn Gln Thr Cys Glu Leu Leu Pro Val Ser 
65                  70                  75                  80  


Gln Ala Ser Trp Ala Cys Asn Leu Ile Leu Gly Thr Pro Asp Ser Gln 
                85                  90                  95      


Lys Leu Thr Ala Val Asp Ile Val Thr Leu Arg Val Met Cys Arg Glu 
            100                 105                 110         


Gly Val Arg Trp Arg Met Met Ala Ile Gln Asp Phe Lys Pro Phe Glu 
        115                 120                 125             


Asn Leu Arg Leu Met Ala Pro Ile Ser Leu Gln Val Val His Val Glu 
    130                 135                 140                 


Thr His Arg Cys Asn Ile Ser Trp Lys Ile Ser Gln Ala Ser His Tyr 
145                 150                 155                 160 


Phe Glu Arg His Leu Glu Phe Glu Ala Arg Thr Leu Ser Pro Gly His 
                165                 170                 175     


Thr Trp Glu Glu Ala Pro Leu Met Thr Leu Lys Gln Lys Gln Glu Trp 
            180                 185                 190         


Ile Cys Leu Glu Thr Leu Thr Pro Asp Thr Gln Tyr Glu Phe Gln Val 
        195                 200                 205             


Arg Val Lys Pro Leu Gln Gly Glu Phe Thr Thr Trp Ser Pro Trp Ser 
    210                 215                 220                 


Gln Pro Leu Ala Phe Arg Thr Lys Pro Ala Ala Leu Gly Lys Asp Thr 
225                 230                 235                 240 


Ile Pro Trp Leu Gly His Leu Leu Val Gly Leu Ser Gly Ala Phe Gly 
                245                 250                 255     


Phe Ile Ile Leu Val Tyr Leu Leu Ile Asn Cys Arg Asn Thr Gly Pro 
            260                 265                 270         


Trp Leu Lys Lys Val Leu Lys Cys His Thr Pro Asp Pro Ser Lys Phe 
        275                 280                 285             


Phe Ser Gln Leu Thr Ser Glu His Gly Gly Asp Val Gln Lys Trp Leu 
    290                 295                 300                 


Ser Ser Pro Phe Pro Ser Ser Ser Phe Ser Pro Gly Gly Leu Ala Pro 
305                 310                 315                 320 


Glu Ile Ser Pro Leu Glu Val Leu Glu Arg Asp Lys Val Thr Gln Leu 
                325                 330                 335     


Leu Leu Gln Gln Asp Lys Val Pro Glu Pro Ser Ser Leu Ser Ser Asn 
            340                 345                 350         


Arg Ser Leu Thr Ser Cys Phe Thr Asn Gln Gly Tyr Phe Phe Phe His 
        355                 360                 365             


Leu Pro Asp Ala Leu Glu Ile Glu Ala Cys Gln Val Tyr Phe Thr Tyr 
    370                 375                 380                 


Asp Pro Cys Ala Glu Glu Glu Pro Asp Glu Gly Gly Ala Asp Ala Pro 
385                 390                 395                 400 


Thr Gly Ser Ser Pro Gln Pro Leu Arg Pro Leu Ser Ala Glu Asp Asp 
                405                 410                 415     


Ala Tyr Cys Thr Phe Pro Ser Gly Asp Asp Leu Leu Leu Phe Ser Pro 
            420                 425                 430         


Ser Leu Leu Gly Gly Pro Ser Pro Pro Ser Thr Ala Pro Gly Gly Ser 
        435                 440                 445             


Gly Ala Gly Glu Glu Arg Leu Pro Pro Ser Leu Gln Glu Arg Val Pro 
    450                 455                 460                 


Arg Asp Trp Asp Pro Gln Pro Leu Gly Pro Pro Thr Pro Gly Val Pro 
465                 470                 475                 480 


Asp Leu Val Asp Phe Gln Pro Arg Pro Glu Leu Val Leu Arg Glu Ala 
                485                 490                 495     


Gly Glu Gln Val Pro Asp Pro Gly Pro Arg Glu Pro Phe Ser Phe Pro 
            500                 505                 510         


Trp Ala Arg Pro Pro Gly Gln Gly Glu Val Arg Ala Leu Asn Ala Arg 
        515                 520                 525             


Leu Pro Leu Asn Thr Asp Ala Tyr Leu Ser Leu Gln Glu Leu Gln Asp 
    530                 535                 540                 


Gln Asp Pro Thr His Leu Val 
545                 550     


<210>  21
<211>  628
<212>  PRT
<213>  Homo sapiens

<400>  21

Met Glu Pro Pro Asp Ala Pro Ala Gln Ala Arg Gly Ala Pro Arg Leu 
1               5                   10                  15      


Leu Leu Leu Ala Val Leu Leu Ala Ala His Pro Asp Ala Gln Ala Glu 
            20                  25                  30          


Val Arg Leu Ser Val Pro Pro Leu Val Glu Val Met Arg Gly Lys Ser 
        35                  40                  45              


Val Ile Leu Asp Cys Thr Pro Thr Gly Thr His Asp His Tyr Met Leu 
    50                  55                  60                  


Glu Trp Phe Leu Thr Asp Arg Ser Gly Ala Arg Pro Arg Leu Ala Ser 
65                  70                  75                  80  


Ala Glu Met Gln Gly Ser Glu Leu Gln Val Thr Met His Asp Thr Arg 
                85                  90                  95      


Gly Arg Ser Pro Pro Tyr Gln Leu Asp Ser Gln Gly Arg Leu Val Leu 
            100                 105                 110         


Ala Glu Ala Gln Val Gly Asp Glu Arg Asp Tyr Val Cys Val Val Arg 
        115                 120                 125             


Ala Gly Ala Ala Gly Thr Ala Glu Ala Thr Ala Arg Leu Asn Val Phe 
    130                 135                 140                 


Ala Lys Pro Glu Ala Thr Glu Val Ser Pro Asn Lys Gly Thr Leu Ser 
145                 150                 155                 160 


Val Met Glu Asp Ser Ala Gln Glu Ile Ala Thr Cys Asn Ser Arg Asn 
                165                 170                 175     


Gly Asn Pro Ala Pro Lys Ile Thr Trp Tyr Arg Asn Gly Gln Arg Leu 
            180                 185                 190         


Glu Val Pro Val Glu Met Asn Pro Glu Gly Tyr Met Thr Ser Arg Thr 
        195                 200                 205             


Val Arg Glu Ala Ser Gly Leu Leu Ser Leu Thr Ser Thr Leu Tyr Leu 
    210                 215                 220                 


Arg Leu Arg Lys Asp Asp Arg Asp Ala Ser Phe His Cys Ala Ala His 
225                 230                 235                 240 


Tyr Ser Leu Pro Glu Gly Arg His Gly Arg Leu Asp Ser Pro Thr Phe 
                245                 250                 255     


His Leu Thr Leu His Tyr Pro Thr Glu His Val Gln Phe Trp Val Gly 
            260                 265                 270         


Ser Pro Ser Thr Pro Ala Gly Trp Val Arg Glu Gly Asp Thr Val Gln 
        275                 280                 285             


Leu Leu Cys Arg Gly Asp Gly Ser Pro Ser Pro Glu Tyr Thr Leu Phe 
    290                 295                 300                 


Arg Leu Gln Asp Glu Gln Glu Glu Val Leu Asn Val Asn Leu Glu Gly 
305                 310                 315                 320 


Asn Leu Thr Leu Glu Gly Val Thr Arg Gly Gln Ser Gly Thr Tyr Gly 
                325                 330                 335     


Cys Arg Val Glu Asp Tyr Asp Ala Ala Asp Asp Val Gln Leu Ser Lys 
            340                 345                 350         


Thr Leu Glu Leu Arg Val Ala Tyr Leu Asp Pro Leu Glu Leu Ser Glu 
        355                 360                 365             


Gly Lys Val Leu Ser Leu Pro Leu Asn Ser Ser Ala Val Val Asn Cys 
    370                 375                 380                 


Ser Val His Gly Leu Pro Thr Pro Ala Leu Arg Trp Thr Lys Asp Ser 
385                 390                 395                 400 


Thr Pro Leu Gly Asp Gly Pro Met Leu Ser Leu Ser Ser Ile Thr Phe 
                405                 410                 415     


Asp Ser Asn Gly Thr Tyr Val Cys Glu Ala Ser Leu Pro Thr Val Pro 
            420                 425                 430         


Val Leu Ser Arg Thr Gln Asn Phe Thr Leu Leu Val Gln Gly Ser Pro 
        435                 440                 445             


Glu Leu Lys Thr Ala Glu Ile Glu Pro Lys Ala Asp Gly Ser Trp Arg 
    450                 455                 460                 


Glu Gly Asp Glu Val Thr Leu Ile Cys Ser Ala Arg Gly His Pro Asp 
465                 470                 475                 480 


Pro Lys Leu Ser Trp Ser Gln Leu Gly Gly Ser Pro Ala Glu Pro Ile 
                485                 490                 495     


Pro Gly Arg Gln Gly Trp Val Ser Ser Ser Leu Thr Leu Lys Val Thr 
            500                 505                 510         


Ser Ala Leu Ser Arg Asp Gly Ile Ser Cys Glu Ala Ser Asn Pro His 
        515                 520                 525             


Gly Asn Lys Arg His Val Phe His Phe Gly Thr Val Ser Pro Gln Thr 
    530                 535                 540                 


Ser Gln Ala Gly Val Ala Val Met Ala Val Ala Val Ser Val Gly Leu 
545                 550                 555                 560 


Leu Leu Leu Val Val Ala Val Phe Tyr Cys Val Arg Arg Lys Gly Gly 
                565                 570                 575     


Pro Cys Cys Arg Gln Arg Arg Glu Lys Gly Ala Pro Pro Pro Gly Glu 
            580                 585                 590         


Pro Gly Leu Ser His Ser Gly Ser Glu Gln Pro Glu Gln Thr Gly Leu 
        595                 600                 605             


Leu Met Gly Gly Ala Ser Gly Gly Ala Arg Gly Gly Ser Gly Gly Phe 
    610                 615                 620                 


Gly Asp Glu Cys 
625             


<210>  22
<211>  119
<212>  PRT
<213>  Artificial Sequence

<220>  
<223>  heavy chain variable region

<400>  22

Glu Val Gln Leu Leu Glu Ser Gly Gly Gly Leu Val Gln Pro Gly Gly 
1               5                   10                  15      


Ser Leu Arg Leu Ser Cys Ala Ala Ser Gly Phe Ser Val Thr Ser Tyr 
            20                  25                  30          


Gly Val His Trp Ile Arg Gln Ala Pro Gly Lys Gly Leu Glu Trp Leu 
        35                  40                  45              


Gly Val Ile Trp Ser Gly Gly Ser Thr Asp Tyr Asn Ala Ala Phe Ile 
    50                  55                  60                  


Ser Arg Leu Thr Ile Ser Lys Asp Asn Ser Lys Asn Thr Val Tyr Phe 
65                  70                  75                  80  


Gln Met Asn Ser Leu Gln Ala Glu Asp Thr Ala Ile Tyr Tyr Cys Ala 
                85                  90                  95      


Arg Ala Gly Asp Tyr Asn Tyr Asp Gly Phe Ala Tyr Trp Gly Gln Gly 
            100                 105                 110         


Thr Leu Val Thr Val Ser Ser 
        115                 


<210>  23
<211>  30
<212>  PRT
<213>  Artificial Sequence

<220>  
<223>  heavy chain FR1

<400>  23

Glu Val Gln Leu Leu Glu Ser Gly Gly Gly Leu Val Gln Pro Gly Gly 
1               5                   10                  15      


Ser Leu Arg Leu Ser Cys Ala Ala Ser Gly Phe Ser Val Thr 
            20                  25                  30  


<210>  24
<211>  5
<212>  PRT
<213>  Mus musculus

<400>  24

Ser Tyr Gly Val His 
1               5   


<210>  25
<211>  14
<212>  PRT
<213>  Artificial Sequence

<220>  
<223>  heavy chain FR2

<400>  25

Trp Ile Arg Gln Ala Pro Gly Lys Gly Leu Glu Trp Leu Gly 
1               5                   10                  


<210>  26
<211>  32
<212>  PRT
<213>  Artificial Sequence

<220>  
<223>  heavy chain FR3

<400>  26

Arg Leu Thr Ile Ser Lys Asp Asn Ser Lys Asn Thr Val Tyr Phe Gln 
1               5                   10                  15      


Met Asn Ser Leu Gln Ala Glu Asp Thr Ala Ile Tyr Tyr Cys Ala Arg 
            20                  25                  30          


<210>  27
<211>  11
<212>  PRT
<213>  Mus musculus

<400>  27

Ala Gly Asp Tyr Asn Tyr Asp Gly Phe Ala Tyr 
1               5                   10      


<210>  28
<211>  106
<212>  PRT
<213>  Artificial Sequence

<220>  
<223>  light chain variable region

<400>  28

Asp Ile Val Leu Thr Gln Ser Pro Ser Ser Leu Ser Ala Ser Val Gly 
1               5                   10                  15      


Asp Arg Val Thr Ile Thr Cys Ser Gly Ser Ser Ser Val Ser Phe Met 
            20                  25                  30          


Tyr Trp Tyr Gln Gln Arg Pro Gly Lys Ala Pro Arg Leu Leu Ile Tyr 
        35                  40                  45              


Asp Thr Ser Asn Leu Ala Ser Gly Val Pro Ser Arg Phe Ser Gly Ser 
    50                  55                  60                  


Gly Ser Gly Thr Ser Tyr Thr Phe Thr Ile Ser Ser Leu Gln Pro Glu 
65                  70                  75                  80  


Asp Ile Ala Thr Tyr Tyr Cys Gln Gln Trp Ser Thr Tyr Pro Leu Thr 
                85                  90                  95      


Phe Gly Gln Gly Thr Lys Val Glu Val Lys 
            100                 105     


<210>  29
<211>  23
<212>  PRT
<213>  Artificial Sequence

<220>  
<223>  light chain FR1

<400>  29

Asp Ile Val Leu Thr Gln Ser Pro Ser Ser Leu Ser Ala Ser Val Gly 
1               5                   10                  15      


Asp Arg Val Thr Ile Thr Cys 
            20              


<210>  30
<211>  10
<212>  PRT
<213>  Mus musculus

<400>  30

Ser Gly Ser Ser Ser Val Ser Phe Met Tyr 
1               5                   10  


<210>  31
<211>  10
<212>  PRT
<213>  Artificial Sequence

<220>  
<223>  light chain FR4

<400>  31

Phe Gly Gln Gly Thr Lys Val Glu Val Lys 
1               5                   10  


<210>  32
<211>  327
<212>  PRT
<213>  Homo sapiens

<400>  32

Ala Ser Thr Lys Gly Pro Ser Val Phe Pro Leu Ala Pro Cys Ser Arg 
1               5                   10                  15      


Ser Thr Ser Glu Ser Thr Ala Ala Leu Gly Cys Leu Val Lys Asp Tyr 
            20                  25                  30          


Phe Pro Glu Pro Val Thr Val Ser Trp Asn Ser Gly Ala Leu Thr Ser 
        35                  40                  45              


Gly Val His Thr Phe Pro Ala Val Leu Gln Ser Ser Gly Leu Tyr Ser 
    50                  55                  60                  


Leu Ser Ser Val Val Thr Val Pro Ser Ser Ser Leu Gly Thr Lys Thr 
65                  70                  75                  80  


Tyr Thr Cys Asn Val Asp His Lys Pro Ser Asn Thr Lys Val Asp Lys 
                85                  90                  95      


Arg Val Glu Ser Lys Tyr Gly Pro Pro Cys Pro Ser Cys Pro Ala Pro 
            100                 105                 110         


Glu Phe Leu Gly Gly Pro Ser Val Phe Leu Phe Pro Pro Lys Pro Lys 
        115                 120                 125             


Asp Thr Leu Met Ile Ser Arg Thr Pro Glu Val Thr Cys Val Val Val 
    130                 135                 140                 


Asp Val Ser Gln Glu Asp Pro Glu Val Gln Phe Asn Trp Tyr Val Asp 
145                 150                 155                 160 


Gly Val Glu Val His Asn Ala Lys Thr Lys Pro Arg Glu Glu Gln Phe 
                165                 170                 175     


Asn Ser Thr Tyr Arg Val Val Ser Val Leu Thr Val Leu His Gln Asp 
            180                 185                 190         


Trp Leu Asn Gly Lys Glu Tyr Lys Cys Lys Val Ser Asn Lys Gly Leu 
        195                 200                 205             


Pro Ser Ser Ile Glu Lys Thr Ile Ser Lys Ala Lys Gly Gln Pro Arg 
    210                 215                 220                 


Glu Pro Gln Val Tyr Thr Leu Pro Pro Ser Gln Glu Glu Met Thr Lys 
225                 230                 235                 240 


Asn Gln Val Ser Leu Thr Cys Leu Val Lys Gly Phe Tyr Pro Ser Asp 
                245                 250                 255     


Ile Ala Val Glu Trp Glu Ser Asn Gly Gln Pro Glu Asn Asn Tyr Lys 
            260                 265                 270         


Thr Thr Pro Pro Val Leu Asp Ser Asp Gly Ser Phe Phe Leu Tyr Ser 
        275                 280                 285             


Arg Leu Thr Val Asp Lys Ser Arg Trp Gln Glu Gly Asn Val Phe Ser 
    290                 295                 300                 


Cys Ser Val Met His Glu Ala Leu His Asn His Tyr Thr Gln Lys Ser 
305                 310                 315                 320 


Leu Ser Leu Ser Leu Gly Lys 
                325         


<210>  33
<211>  327
<212>  PRT
<213>  Artificial Sequence

<220>  
<223>  IgG4 (S228P)

<400>  33

Ala Ser Thr Lys Gly Pro Ser Val Phe Pro Leu Ala Pro Cys Ser Arg 
1               5                   10                  15      


Ser Thr Ser Glu Ser Thr Ala Ala Leu Gly Cys Leu Val Lys Asp Tyr 
            20                  25                  30          


Phe Pro Glu Pro Val Thr Val Ser Trp Asn Ser Gly Ala Leu Thr Ser 
        35                  40                  45              


Gly Val His Thr Phe Pro Ala Val Leu Gln Ser Ser Gly Leu Tyr Ser 
    50                  55                  60                  


Leu Ser Ser Val Val Thr Val Pro Ser Ser Ser Leu Gly Thr Lys Thr 
65                  70                  75                  80  


Tyr Thr Cys Asn Val Asp His Lys Pro Ser Asn Thr Lys Val Asp Lys 
                85                  90                  95      


Arg Val Glu Ser Lys Tyr Gly Pro Pro Cys Pro Pro Cys Pro Ala Pro 
            100                 105                 110         


Glu Phe Leu Gly Gly Pro Ser Val Phe Leu Phe Pro Pro Lys Pro Lys 
        115                 120                 125             


Asp Thr Leu Met Ile Ser Arg Thr Pro Glu Val Thr Cys Val Val Val 
    130                 135                 140                 


Asp Val Ser Gln Glu Asp Pro Glu Val Gln Phe Asn Trp Tyr Val Asp 
145                 150                 155                 160 


Gly Val Glu Val His Asn Ala Lys Thr Lys Pro Arg Glu Glu Gln Phe 
                165                 170                 175     


Asn Ser Thr Tyr Arg Val Val Ser Val Leu Thr Val Leu His Gln Asp 
            180                 185                 190         


Trp Leu Asn Gly Lys Glu Tyr Lys Cys Lys Val Ser Asn Lys Gly Leu 
        195                 200                 205             


Pro Ser Ser Ile Glu Lys Thr Ile Ser Lys Ala Lys Gly Gln Pro Arg 
    210                 215                 220                 


Glu Pro Gln Val Tyr Thr Leu Pro Pro Ser Gln Glu Glu Met Thr Lys 
225                 230                 235                 240 


Asn Gln Val Ser Leu Thr Cys Leu Val Lys Gly Phe Tyr Pro Ser Asp 
                245                 250                 255     


Ile Ala Val Glu Trp Glu Ser Asn Gly Gln Pro Glu Asn Asn Tyr Lys 
            260                 265                 270         


Thr Thr Pro Pro Val Leu Asp Ser Asp Gly Ser Phe Phe Leu Tyr Ser 
        275                 280                 285             


Arg Leu Thr Val Asp Lys Ser Arg Trp Gln Glu Gly Asn Val Phe Ser 
    290                 295                 300                 


Cys Ser Val Met His Glu Ala Leu His Asn His Tyr Thr Gln Lys Ser 
305                 310                 315                 320 


Leu Ser Leu Ser Leu Gly Lys 
                325         


<210>  34
<211>  330
<212>  PRT
<213>  Homo sapiens

<400>  34

Ala Ser Thr Lys Gly Pro Ser Val Phe Pro Leu Ala Pro Ser Ser Lys 
1               5                   10                  15      


Ser Thr Ser Gly Gly Thr Ala Ala Leu Gly Cys Leu Val Lys Asp Tyr 
            20                  25                  30          


Phe Pro Glu Pro Val Thr Val Ser Trp Asn Ser Gly Ala Leu Thr Ser 
        35                  40                  45              


Gly Val His Thr Phe Pro Ala Val Leu Gln Ser Ser Gly Leu Tyr Ser 
    50                  55                  60                  


Leu Ser Ser Val Val Thr Val Pro Ser Ser Ser Leu Gly Thr Gln Thr 
65                  70                  75                  80  


Tyr Ile Cys Asn Val Asn His Lys Pro Ser Asn Thr Lys Val Asp Lys 
                85                  90                  95      


Lys Val Glu Pro Lys Ser Cys Asp Lys Thr His Thr Cys Pro Pro Cys 
            100                 105                 110         


Pro Ala Pro Glu Leu Leu Gly Gly Pro Ser Val Phe Leu Phe Pro Pro 
        115                 120                 125             


Lys Pro Lys Asp Thr Leu Met Ile Ser Arg Thr Pro Glu Val Thr Cys 
    130                 135                 140                 


Val Val Val Asp Val Ser His Glu Asp Pro Glu Val Lys Phe Asn Trp 
145                 150                 155                 160 


Tyr Val Asp Gly Val Glu Val His Asn Ala Lys Thr Lys Pro Arg Glu 
                165                 170                 175     


Glu Gln Tyr Asn Ser Thr Tyr Arg Val Val Ser Val Leu Thr Val Leu 
            180                 185                 190         


His Gln Asp Trp Leu Asn Gly Lys Glu Tyr Lys Cys Lys Val Ser Asn 
        195                 200                 205             


Lys Ala Leu Pro Ala Pro Ile Glu Lys Thr Ile Ser Lys Ala Lys Gly 
    210                 215                 220                 


Gln Pro Arg Glu Pro Gln Val Tyr Thr Leu Pro Pro Ser Arg Asp Glu 
225                 230                 235                 240 


Leu Thr Lys Asn Gln Val Ser Leu Thr Cys Leu Val Lys Gly Phe Tyr 
                245                 250                 255     


Pro Ser Asp Ile Ala Val Glu Trp Glu Ser Asn Gly Gln Pro Glu Asn 
            260                 265                 270         


Asn Tyr Lys Thr Thr Pro Pro Val Leu Asp Ser Asp Gly Ser Phe Phe 
        275                 280                 285             


Leu Tyr Ser Lys Leu Thr Val Asp Lys Ser Arg Trp Gln Gln Gly Asn 
    290                 295                 300                 


Val Phe Ser Cys Ser Val Met His Glu Ala Leu His Asn His Tyr Thr 
305                 310                 315                 320 


Gln Lys Ser Leu Ser Leu Ser Pro Gly Lys 
                325                 330 


<210>  35
<211>  330
<212>  PRT
<213>  Artificial Sequence

<220>  
<223>  IgG1-3M

<400>  35

Ala Ser Thr Lys Gly Pro Ser Val Phe Pro Leu Ala Pro Ser Ser Lys 
1               5                   10                  15      


Ser Thr Ser Gly Gly Thr Ala Ala Leu Gly Cys Leu Val Lys Asp Tyr 
            20                  25                  30          


Phe Pro Glu Pro Val Thr Val Ser Trp Asn Ser Gly Ala Leu Thr Ser 
        35                  40                  45              


Gly Val His Thr Phe Pro Ala Val Leu Gln Ser Ser Gly Leu Tyr Ser 
    50                  55                  60                  


Leu Ser Ser Val Val Thr Val Pro Ser Ser Ser Leu Gly Thr Gln Thr 
65                  70                  75                  80  


Tyr Ile Cys Asn Val Asn His Lys Pro Ser Asn Thr Lys Val Asp Lys 
                85                  90                  95      


Lys Val Glu Pro Lys Ser Cys Asp Lys Thr His Thr Cys Pro Pro Cys 
            100                 105                 110         


Pro Ala Pro Glu Ala Ala Gly Ala Pro Ser Val Phe Leu Phe Pro Pro 
        115                 120                 125             


Lys Pro Lys Asp Thr Leu Met Ile Ser Arg Thr Pro Glu Val Thr Cys 
    130                 135                 140                 


Val Val Val Asp Val Ser His Glu Asp Pro Glu Val Lys Phe Asn Trp 
145                 150                 155                 160 


Tyr Val Asp Gly Val Glu Val His Asn Ala Lys Thr Lys Pro Arg Glu 
                165                 170                 175     


Glu Gln Tyr Asn Ser Thr Tyr Arg Val Val Ser Val Leu Thr Val Leu 
            180                 185                 190         


His Gln Asp Trp Leu Asn Gly Lys Glu Tyr Lys Cys Lys Val Ser Asn 
        195                 200                 205             


Lys Ala Leu Pro Ala Pro Ile Glu Lys Thr Ile Ser Lys Ala Lys Gly 
    210                 215                 220                 


Gln Pro Arg Glu Pro Gln Val Tyr Thr Leu Pro Pro Ser Arg Asp Glu 
225                 230                 235                 240 


Leu Thr Lys Asn Gln Val Ser Leu Thr Cys Leu Val Lys Gly Phe Tyr 
                245                 250                 255     


Pro Ser Asp Ile Ala Val Glu Trp Glu Ser Asn Gly Gln Pro Glu Asn 
            260                 265                 270         


Asn Tyr Lys Thr Thr Pro Pro Val Leu Asp Ser Asp Gly Ser Phe Phe 
        275                 280                 285             


Leu Tyr Ser Lys Leu Thr Val Asp Lys Ser Arg Trp Gln Gln Gly Asn 
    290                 295                 300                 


Val Phe Ser Cys Ser Val Met His Glu Ala Leu His Asn His Tyr Thr 
305                 310                 315                 320 


Gln Lys Ser Leu Ser Leu Ser Pro Gly Lys 
                325                 330 


<210>  36
<211>  326
<212>  PRT
<213>  Homo sapiens

<400>  36

Ala Ser Thr Lys Gly Pro Ser Val Phe Pro Leu Ala Pro Cys Ser Arg 
1               5                   10                  15      


Ser Thr Ser Glu Ser Thr Ala Ala Leu Gly Cys Leu Val Lys Asp Tyr 
            20                  25                  30          


Phe Pro Glu Pro Val Thr Val Ser Trp Asn Ser Gly Ala Leu Thr Ser 
        35                  40                  45              


Gly Val His Thr Phe Pro Ala Val Leu Gln Ser Ser Gly Leu Tyr Ser 
    50                  55                  60                  


Leu Ser Ser Val Val Thr Val Pro Ser Ser Asn Phe Gly Thr Gln Thr 
65                  70                  75                  80  


Tyr Thr Cys Asn Val Asp His Lys Pro Ser Asn Thr Lys Val Asp Lys 
                85                  90                  95      


Thr Val Glu Arg Lys Cys Cys Val Glu Cys Pro Pro Cys Pro Ala Pro 
            100                 105                 110         


Pro Val Ala Gly Pro Ser Val Phe Leu Phe Pro Pro Lys Pro Lys Asp 
        115                 120                 125             


Thr Leu Met Ile Ser Arg Thr Pro Glu Val Thr Cys Val Val Val Asp 
    130                 135                 140                 


Val Ser His Glu Asp Pro Glu Val Gln Phe Asn Trp Tyr Val Asp Gly 
145                 150                 155                 160 


Val Glu Val His Asn Ala Lys Thr Lys Pro Arg Glu Glu Gln Phe Asn 
                165                 170                 175     


Ser Thr Phe Arg Val Val Ser Val Leu Thr Val Val His Gln Asp Trp 
            180                 185                 190         


Leu Asn Gly Lys Glu Tyr Lys Cys Lys Val Ser Asn Lys Gly Leu Pro 
        195                 200                 205             


Ala Pro Ile Glu Lys Thr Ile Ser Lys Thr Lys Gly Gln Pro Arg Glu 
    210                 215                 220                 


Pro Gln Val Tyr Thr Leu Pro Pro Ser Arg Glu Glu Met Thr Lys Asn 
225                 230                 235                 240 


Gln Val Ser Leu Thr Cys Leu Val Lys Gly Phe Tyr Pro Ser Asp Ile 
                245                 250                 255     


Ser Val Glu Trp Glu Ser Asn Gly Gln Pro Glu Asn Asn Tyr Lys Thr 
            260                 265                 270         


Thr Pro Pro Met Leu Asp Ser Asp Gly Ser Phe Phe Leu Tyr Ser Lys 
        275                 280                 285             


Leu Thr Val Asp Lys Ser Arg Trp Gln Gln Gly Asn Val Phe Ser Cys 
    290                 295                 300                 


Ser Val Met His Glu Ala Leu His Asn His Tyr Thr Gln Lys Ser Leu 
305                 310                 315                 320 


Ser Leu Ser Pro Gly Lys 
                325     


<210>  37
<211>  330
<212>  PRT
<213>  Homo sapiens

<400>  37

Ala Ser Thr Lys Gly Pro Ser Val Phe Pro Leu Ala Pro Ser Ser Lys 
1               5                   10                  15      


Ser Thr Ser Gly Gly Thr Ala Ala Leu Gly Cys Leu Val Lys Asp Tyr 
            20                  25                  30          


Phe Pro Glu Pro Val Thr Val Ser Trp Asn Ser Gly Ala Leu Thr Ser 
        35                  40                  45              


Gly Val His Thr Phe Pro Ala Val Leu Gln Ser Ser Gly Leu Tyr Ser 
    50                  55                  60                  


Leu Ser Ser Val Val Thr Val Pro Ser Ser Ser Leu Gly Thr Gln Thr 
65                  70                  75                  80  


Tyr Ile Cys Asn Val Asn His Lys Pro Ser Asn Thr Lys Val Asp Lys 
                85                  90                  95      


Lys Val Glu Pro Lys Ser Cys Asp Lys Thr His Thr Cys Pro Pro Cys 
            100                 105                 110         


Pro Ala Pro Glu Leu Leu Gly Gly Pro Ser Val Phe Leu Phe Pro Pro 
        115                 120                 125             


Lys Pro Lys Asp Thr Leu Met Ile Ser Arg Thr Pro Glu Val Thr Cys 
    130                 135                 140                 


Val Val Val Asp Val Ser His Glu Asp Pro Glu Val Lys Phe Asn Trp 
145                 150                 155                 160 


Tyr Val Asp Gly Val Glu Val His Asn Ala Lys Thr Lys Pro Arg Glu 
                165                 170                 175     


Glu Gln Tyr Asn Ser Thr Tyr Arg Val Val Ser Val Leu Thr Val Leu 
            180                 185                 190         


His Gln Asp Trp Leu Asn Gly Lys Glu Tyr Lys Cys Lys Val Ser Asn 
        195                 200                 205             


Lys Ala Leu Pro Ala Pro Ile Glu Lys Thr Ile Ser Lys Ala Lys Gly 
    210                 215                 220                 


Gln Pro Arg Glu Pro Gln Val Tyr Thr Leu Pro Pro Ser Arg Glu Glu 
225                 230                 235                 240 


Met Thr Lys Asn Gln Val Ser Leu Thr Cys Leu Val Lys Gly Phe Tyr 
                245                 250                 255     


Pro Ser Asp Ile Ala Val Glu Trp Glu Ser Asn Gly Gln Pro Glu Asn 
            260                 265                 270         


Asn Tyr Lys Thr Thr Pro Pro Val Leu Asp Ser Asp Gly Ser Phe Phe 
        275                 280                 285             


Leu Tyr Ser Lys Leu Thr Val Asp Lys Ser Arg Trp Gln Gln Gly Asn 
    290                 295                 300                 


Val Phe Ser Cys Ser Val Met His Glu Ala Leu His Asn His Tyr Thr 
305                 310                 315                 320 


Gln Lys Ser Leu Ser Leu Ser Pro Gly Lys 
                325                 330 


<210>  38
<211>  329
<212>  PRT
<213>  Homo sapiens

<400>  38

Ala Ser Thr Lys Gly Pro Ser Val Phe Pro Leu Ala Pro Ser Ser Lys 
1               5                   10                  15      


Ser Thr Ser Gly Gly Thr Ala Ala Leu Gly Cys Leu Val Lys Asp Tyr 
            20                  25                  30          


Phe Pro Glu Pro Val Thr Val Ser Trp Asn Ser Gly Ala Leu Thr Ser 
        35                  40                  45              


Gly Val His Thr Phe Pro Ala Val Leu Gln Ser Ser Gly Leu Tyr Ser 
    50                  55                  60                  


Leu Ser Ser Val Val Thr Val Pro Ser Ser Ser Leu Gly Thr Gln Thr 
65                  70                  75                  80  


Tyr Ile Cys Asn Val Asn His Lys Pro Ser Asn Thr Lys Val Asp Lys 
                85                  90                  95      


Lys Val Glu Pro Lys Ser Cys Asp Lys Thr His Thr Cys Pro Pro Cys 
            100                 105                 110         


Pro Ala Pro Glu Ala Ala Gly Ala Pro Ser Val Phe Leu Phe Pro Pro 
        115                 120                 125             


Lys Pro Lys Asp Thr Leu Met Ile Ser Arg Thr Pro Glu Val Thr Cys 
    130                 135                 140                 


Val Val Val Asp Val Ser His Glu Asp Pro Glu Val Lys Phe Asn Trp 
145                 150                 155                 160 


Tyr Val Asp Gly Val Glu Val His Asn Ala Lys Thr Lys Pro Arg Glu 
                165                 170                 175     


Glu Gln Tyr Asn Ser Thr Tyr Arg Val Val Ser Val Leu Thr Val Leu 
            180                 185                 190         


His Gln Asp Trp Leu Asn Gly Lys Glu Tyr Lys Cys Lys Val Ser Asn 
        195                 200                 205             


Lys Ala Leu Pro Ala Pro Ile Glu Lys Thr Ile Ser Lys Ala Lys Gly 
    210                 215                 220                 


Gln Pro Arg Glu Pro Gln Val Tyr Thr Leu Pro Pro Ser Arg Glu Glu 
225                 230                 235                 240 


Met Lys Asn Gln Val Ser Leu Thr Cys Leu Val Lys Gly Phe Tyr Pro 
                245                 250                 255     


Ser Asp Ile Ala Val Glu Trp Glu Ser Asn Gly Gln Pro Glu Asn Asn 
            260                 265                 270         


Tyr Lys Thr Thr Pro Pro Val Leu Asp Ser Asp Gly Ser Phe Phe Leu 
        275                 280                 285             


Tyr Ser Lys Leu Thr Val Asp Lys Ser Arg Trp Gln Gln Gly Asn Val 
    290                 295                 300                 


Phe Ser Cys Ser Val Met His Glu Ala Leu His Asn His Tyr Thr Gln 
305                 310                 315                 320 


Lys Ser Leu Ser Leu Ser Pro Gly Lys 
                325                 


<210>  39
<211>  10
<212>  PRT
<213>  Artificial Sequence

<220>  
<223>  HCDR1


<220>
<221>  MISC_FEATURE
<222>  (8)..(8)
<223>  Xaa is Leu or any other amino acid

<400>  39

Gly Phe Thr Phe Ser Ser Tyr Xaa Met Ser 
1               5                   10  


<210>  40
<211>  19
<212>  PRT
<213>  Artificial Sequence

<220>  
<223>  HCDR2


<220>
<221>  MISC_FEATURE
<222>  (1)..(1)
<223>  Xaa is Val or a conservative substitution of Val

<220>
<221>  MISC_FEATURE
<222>  (3)..(3)
<223>  Xaa is Thr or Asn

<220>
<221>  MISC_FEATURE
<222>  (9)..(9)
<223>  Xaa is Ala or Ser

<220>
<221>  MISC_FEATURE
<222>  (10)..(10)
<223>  Xaa is Glu or Asn

<220>
<221>  MISC_FEATURE
<222>  (11)..(11)
<223>  Xaa is Thr or Lys

<220>
<221>  MISC_FEATURE
<222>  (14)..(14)
<223>  Xaa is Pro or Val

<400>  40

Xaa Ala Xaa Ile Ser Gly Gly Gly Xaa Xaa Xaa Tyr Tyr Xaa Asp Ser 
1               5                   10                  15      


Val Lys Gly 
            


<210>  41
<211>  119
<212>  PRT
<213>  Artificial Sequence

<220>  
<223>  MAB01-MAB15 IgG1 Designer variable domain sequence DVH1

<400>  41

Glu Val Gln Leu Leu Glu Ser Gly Gly Gly Leu Val Gln Pro Gly Gly 
1               5                   10                  15      


Ser Leu Arg Leu Ser Cys Ala Ala Ser Gly Phe Ser Val Ser Ser Tyr 
            20                  25                  30          


Gly Met His Trp Val Arg Gln Ala Pro Gly Lys Gly Leu Glu Trp Leu 
        35                  40                  45              


Gly Ala Ile Trp Ser Gly Gly Ser Thr Asp Tyr Ala Asp Ala Val Lys 
    50                  55                  60                  


Gly Arg Phe Thr Ile Ser Arg Asp Asn Ser Lys Asn Thr Leu Tyr Leu 
65                  70                  75                  80  


Gln Met Asn Ser Leu Arg Ala Glu Asp Thr Ala Val Tyr Tyr Cys Ala 
                85                  90                  95      


Arg Ala Gly Asp Lys Asn Tyr Asp Gly Phe Ala Tyr Trp Gly Gln Gly 
            100                 105                 110         


Thr Leu Val Thr Val Ser Ser 
        115                 


<210>  42
<211>  119
<212>  PRT
<213>  Artificial Sequence

<220>  
<223>  MAB01-MAB15 IgG1 Designer variable domain sequence DVH2

<400>  42

Glu Val Gln Leu Leu Glu Ser Gly Gly Gly Leu Val Gln Pro Gly Gly 
1               5                   10                  15      


Ser Leu Arg Leu Ser Cys Ala Ala Ser Gly Phe Ser Val Ser Ser Tyr 
            20                  25                  30          


Gly Met His Trp Val Arg Gln Ala Pro Gly Lys Gly Leu Glu Trp Leu 
        35                  40                  45              


Gly Val Ile Trp Ser Gly Gly Ser Thr Asp Tyr Ala Asp Ala Val Lys 
    50                  55                  60                  


Gly Arg Phe Thr Ile Ser Arg Asp Asn Ser Lys Asn Thr Leu Tyr Leu 
65                  70                  75                  80  


Gln Met Asn Ser Leu Arg Ala Glu Asp Thr Ala Val Tyr Tyr Cys Ala 
                85                  90                  95      


Arg Ala Gly Asp Lys Asn Tyr Asp Gly Phe Ala Tyr Trp Gly Gln Gly 
            100                 105                 110         


Thr Leu Val Thr Val Ser Ser 
        115                 


<210>  43
<211>  119
<212>  PRT
<213>  Artificial Sequence

<220>  
<223>  MAB01-MAB15 IgG1 Designer variable domain sequence DVH3

<400>  43

Glu Val Gln Leu Leu Glu Ser Gly Gly Gly Leu Val Gln Pro Gly Gly 
1               5                   10                  15      


Ser Leu Arg Leu Ser Cys Ala Ala Ser Gly Phe Ser Val Ser Ser Tyr 
            20                  25                  30          


Gly Met His Trp Val Arg Gln Ala Pro Gly Lys Gly Leu Glu Trp Leu 
        35                  40                  45              


Gly Ala Ile Trp Ser Gly Gly Ser Thr Asp Tyr Ala Asp Ala Val Lys 
    50                  55                  60                  


Gly Arg Phe Thr Ile Ser Arg Asp Asn Ser Lys Asn Thr Leu Tyr Leu 
65                  70                  75                  80  


Gln Met Asn Ser Leu Arg Ala Glu Asp Thr Ala Val Tyr Tyr Cys Ala 
                85                  90                  95      


Arg Ala Gly Asp His Asn Tyr Asp Gly Phe Ala Tyr Trp Gly Gln Gly 
            100                 105                 110         


Thr Leu Val Thr Val Ser Ser 
        115                 


<210>  44
<211>  119
<212>  PRT
<213>  Artificial Sequence

<220>  
<223>  MAB01-MAB15 IgG1 Designer variable domain sequence DVH4

<400>  44

Glu Val Gln Leu Leu Glu Ser Gly Gly Gly Leu Val Gln Pro Gly Gly 
1               5                   10                  15      


Ser Leu Arg Leu Ser Cys Ala Ala Ser Gly Phe Ser Val Ser Ser Tyr 
            20                  25                  30          


Gly Met His Trp Val Arg Gln Ala Pro Gly Lys Gly Leu Glu Trp Leu 
        35                  40                  45              


Gly Val Ile Trp Ser Gly Gly Ser Thr Asp Tyr Ala Asp Ala Val Lys 
    50                  55                  60                  


Gly Arg Phe Thr Ile Ser Arg Asp Asn Ser Lys Asn Thr Leu Tyr Leu 
65                  70                  75                  80  


Gln Met Asn Ser Leu Arg Ala Glu Asp Thr Ala Val Tyr Tyr Cys Ala 
                85                  90                  95      


Arg Ala Gly Asp His Asn Tyr Asp Gly Phe Ala Tyr Trp Gly Gln Gly 
            100                 105                 110         


Thr Leu Val Thr Val Ser Ser 
        115                 


<210>  45
<211>  119
<212>  PRT
<213>  Artificial Sequence

<220>  
<223>  MAB01-MAB15 IgG1 Designer variable domain sequence DVH5

<400>  45

Glu Val Gln Leu Leu Glu Ser Gly Gly Gly Leu Val Gln Pro Gly Gly 
1               5                   10                  15      


Ser Leu Arg Leu Ser Cys Ala Ala Ser Gly Phe Ser Val Ser Ser Tyr 
            20                  25                  30          


Gly Met His Trp Val Arg Gln Ala Pro Gly Lys Gly Leu Glu Trp Leu 
        35                  40                  45              


Gly Ala Ile Trp Ser Gly Gly Ser Thr Asp Tyr Asn Asp Ala Val Lys 
    50                  55                  60                  


Gly Arg Phe Thr Ile Ser Arg Asp Asn Ser Lys Asn Thr Leu Tyr Leu 
65                  70                  75                  80  


Gln Met Asn Ser Leu Arg Ala Glu Asp Thr Ala Val Tyr Tyr Cys Ala 
                85                  90                  95      


Arg Ala Gly Asp His Asn Tyr Asp Gly Phe Ala Tyr Trp Gly Gln Gly 
            100                 105                 110         


Thr Leu Val Thr Val Ser Ser 
        115                 


<210>  46
<211>  106
<212>  PRT
<213>  Artificial Sequence

<220>  
<223>  MAB01-MAB15 IgG1 Designer variable domain sequence DVL1

<400>  46

Asp Ile Gln Met Thr Gln Ser Pro Ser Ser Leu Ser Ala Ser Val Gly 
1               5                   10                  15      


Asp Arg Val Thr Ile Thr Cys Gln Ala Ser Gln Ser Ile Ser Tyr Met 
            20                  25                  30          


Tyr Trp Tyr Gln Gln Arg Pro Gly Lys Ala Pro Lys Leu Leu Ile Tyr 
        35                  40                  45              


Asp Thr Ser Asn Leu Ala Thr Gly Val Pro Ser Arg Phe Ser Gly Ser 
    50                  55                  60                  


Gly Ser Gly Thr Ser Tyr Thr Phe Thr Ile Ser Ser Leu Gln Pro Glu 
65                  70                  75                  80  


Asp Ile Ala Thr Tyr Tyr Cys Gln Gln Trp Asp Asn Tyr Pro Leu Thr 
                85                  90                  95      


Phe Gly Gly Gly Thr Lys Val Glu Ile Lys 
            100                 105     


<210>  47
<211>  106
<212>  PRT
<213>  Artificial Sequence

<220>  
<223>  MAB01-MAB15 IgG1 Designer variable domain sequence DVL2

<400>  47

Asp Ile Gln Met Thr Gln Ser Pro Ser Ser Leu Ser Ala Ser Val Gly 
1               5                   10                  15      


Asp Arg Val Thr Ile Thr Cys Gln Ala Ser Gln Asp Ile Ser Tyr Leu 
            20                  25                  30          


Tyr Trp Tyr Gln Gln Arg Pro Gly Lys Ala Pro Lys Leu Leu Ile Tyr 
        35                  40                  45              


Asp Ala Ser Asn Leu Ala Thr Gly Val Pro Ser Arg Phe Ser Gly Ser 
    50                  55                  60                  


Gly Ser Gly Thr Ser Tyr Thr Phe Thr Ile Ser Ser Leu Gln Pro Glu 
65                  70                  75                  80  


Asp Ile Ala Thr Tyr Tyr Cys Gln Gln Trp Asp Asn Tyr Pro Leu Thr 
                85                  90                  95      


Phe Gly Gly Gly Thr Lys Val Glu Ile Lys 
            100                 105     


<210>  48
<211>  106
<212>  PRT
<213>  Artificial Sequence

<220>  
<223>  MAB01-MAB15 IgG1 Designer variable domain sequence DVL3

<400>  48

Asp Ile Gln Met Thr Gln Ser Pro Ser Ser Leu Ser Ala Ser Val Gly 
1               5                   10                  15      


Asp Arg Val Thr Ile Thr Cys Gln Ala Ser Gln Asp Ile Ser Tyr Leu 
            20                  25                  30          


Tyr Trp Tyr Gln Gln Arg Pro Gly Lys Ala Pro Lys Leu Leu Ile Tyr 
        35                  40                  45              


Asp Ala Ser Asn Leu Glu Thr Gly Val Pro Ser Arg Phe Ser Gly Ser 
    50                  55                  60                  


Gly Ser Gly Thr Ser Tyr Thr Phe Thr Ile Ser Ser Leu Gln Pro Glu 
65                  70                  75                  80  


Asp Ile Ala Thr Tyr Tyr Cys Gln Gln Trp Asp Asn Tyr Pro Leu Thr 
                85                  90                  95      


Phe Gly Gly Gly Thr Lys Val Glu Ile Lys 
            100                 105     


<210>  49
<211>  119
<212>  PRT
<213>  Artificial Sequence

<220>  
<223>  06F11-V optimization variable domain VH sequence F11VH-1

<400>  49

Glu Val Gln Leu Leu Glu Ser Gly Gly Gly Leu Val Gln Pro Gly Gly 
1               5                   10                  15      


Ser Leu Arg Leu Ser Cys Ala Ala Ser Gly Phe Ser Val Thr Ser Tyr 
            20                  25                  30          


Gly Val His Trp Ile Arg Gln Ala Pro Gly Lys Gly Leu Glu Trp Leu 
        35                  40                  45              


Gly Ala Ile Trp Ser Gly Gly Ser Thr Gln Tyr Asn Ala Ala Val Lys 
    50                  55                  60                  


Gly Arg Phe Thr Ile Ser Arg Asp Asn Ser Lys Asn Thr Leu Tyr Leu 
65                  70                  75                  80  


Gln Met Asn Ser Leu Arg Ala Glu Asp Thr Ala Val Tyr Tyr Cys Ala 
                85                  90                  95      


Arg Ala Gly Asp Ala Asn Tyr Asp Gly Phe Ala Tyr Trp Gly Gln Gly 
            100                 105                 110         


Thr Leu Val Thr Val Ser Ser 
        115                 


<210>  50
<211>  119
<212>  PRT
<213>  Artificial Sequence

<220>  
<223>  06F11-V optimization variable domain VH sequence F11VH-13

<400>  50

Glu Val Gln Leu Leu Glu Ser Gly Gly Gly Leu Val Gln Pro Gly Gly 
1               5                   10                  15      


Ser Leu Arg Leu Ser Cys Ala Ala Ser Gly Phe Ser Val Thr Ser Tyr 
            20                  25                  30          


Gly Val His Trp Ile Arg Gln Ala Pro Gly Lys Gly Leu Glu Trp Leu 
        35                  40                  45              


Gly Ala Ile Trp Ser Gly Gly Ser Thr Gln Tyr Asn Ala Ala Val Lys 
    50                  55                  60                  


Gly Arg Phe Thr Ile Ser Arg Asp Asn Ser Lys Asn Thr Leu Tyr Leu 
65                  70                  75                  80  


Gln Met Asn Ser Leu Arg Ala Glu Asp Thr Ala Val Tyr Tyr Cys Ala 
                85                  90                  95      


Arg Ala Gly Asp Tyr Asn Tyr Asp Gly Phe Ala Tyr Trp Gly Gln Gly 
            100                 105                 110         


Thr Leu Val Thr Val Ser Ser 
        115                 


<210>  51
<211>  119
<212>  PRT
<213>  Artificial Sequence

<220>  
<223>  06F11-V optimization variable domain VH sequence F11VH-23

<400>  51

Glu Val Gln Leu Leu Glu Ser Gly Gly Gly Leu Val Gln Pro Gly Gly 
1               5                   10                  15      


Ser Leu Arg Leu Ser Cys Ala Ala Ser Gly Phe Thr Val Thr Ser Tyr 
            20                  25                  30          


Ala Val His Trp Val Arg Gln Ala Pro Gly Lys Gly Leu Glu Trp Leu 
        35                  40                  45              


Gly Val Ile Trp Ser Gly Gly Ser Thr Asp Tyr Asn Ala Ala Phe Ile 
    50                  55                  60                  


Ser Arg Leu Thr Ile Ser Lys Asp Asn Ser Lys Asn Thr Val Tyr Phe 
65                  70                  75                  80  


Gln Met Asn Ser Leu Arg Ala Glu Asp Thr Ala Val Tyr Tyr Cys Ala 
                85                  90                  95      


Arg Ala Gly Asp Tyr Asn Tyr Asp Gly Phe Ala Tyr Trp Gly Gln Gly 
            100                 105                 110         


Thr Leu Val Thr Val Ser Ser 
        115                 


<210>  52
<211>  119
<212>  PRT
<213>  Artificial Sequence

<220>  
<223>  06F11-V optimization variable domain VH sequence F11VH-12

<400>  52

Glu Val Gln Leu Leu Glu Ser Gly Gly Gly Leu Val Gln Pro Gly Gly 
1               5                   10                  15      


Ser Leu Arg Leu Ser Cys Ala Ala Ser Gly Phe Ser Val Thr Ser Tyr 
            20                  25                  30          


Gly Val His Trp Ile Arg Gln Ala Pro Gly Lys Gly Leu Glu Trp Leu 
        35                  40                  45              


Gly Val Ile Trp Ser Gly Gly Ser Thr Asp Tyr Asn Ala Ala Phe Ile 
    50                  55                  60                  


Ser Arg Leu Thr Ile Ser Lys Asp Asn Ser Lys Asn Thr Val Tyr Phe 
65                  70                  75                  80  


Gln Met Asn Ser Leu Arg Ala Glu Asp Thr Ala Val Tyr Tyr Cys Ala 
                85                  90                  95      


Arg Ala Gly Asp Ala Asn Tyr Asp Gly Phe Ala Tyr Trp Gly Gln Gly 
            100                 105                 110         


Thr Leu Val Thr Val Ser Ser 
        115                 


<210>  53
<211>  119
<212>  PRT
<213>  Artificial Sequence

<220>  
<223>  06F11-V optimization variable domain VH sequence F11VH-123

<400>  53

Glu Val Gln Leu Leu Glu Ser Gly Gly Gly Leu Val Gln Pro Gly Gly 
1               5                   10                  15      


Ser Leu Arg Leu Ser Cys Ala Ala Ser Gly Phe Ser Val Thr Ser Tyr 
            20                  25                  30          


Gly Val His Trp Ile Arg Gln Ala Pro Gly Lys Gly Leu Glu Trp Leu 
        35                  40                  45              


Gly Val Ile Trp Ser Gly Gly Ser Thr Asp Tyr Asn Ala Ala Phe Ile 
    50                  55                  60                  


Ser Arg Leu Thr Ile Ser Lys Asp Asn Ser Lys Asn Thr Val Tyr Phe 
65                  70                  75                  80  


Gln Met Asn Ser Leu Arg Ala Glu Asp Thr Ala Val Tyr Tyr Cys Ala 
                85                  90                  95      


Arg Ala Gly Asp Tyr Asn Tyr Asp Gly Phe Ala Tyr Trp Gly Gln Gly 
            100                 105                 110         


Thr Leu Val Thr Val Ser Ser 
        115                 


<210>  54
<211>  106
<212>  PRT
<213>  Artificial Sequence

<220>  
<223>  06F11-V optimization variable domain VK sequence F11VK-12

<400>  54

Asp Ile Gln Met Thr Gln Ser Pro Ser Ser Leu Ser Ala Ser Val Gly 
1               5                   10                  15      


Asp Arg Val Thr Ile Thr Cys Gln Ala Ser Ser Ser Val Ser Phe Met 
            20                  25                  30          


Tyr Trp Tyr Gln Gln Arg Pro Gly Lys Ala Pro Arg Leu Leu Ile Tyr 
        35                  40                  45              


Asp Thr Ser Asn Leu Ala Ser Gly Val Pro Ser Arg Phe Ser Gly Ser 
    50                  55                  60                  


Gly Ser Gly Thr Ser Tyr Thr Phe Thr Ile Ser Ser Leu Gln Pro Glu 
65                  70                  75                  80  


Asp Ile Ala Thr Tyr Tyr Cys Gln Gln Trp Asp Thr Tyr Pro Leu Thr 
                85                  90                  95      


Phe Gly Gly Gly Thr Lys Val Glu Ile Lys 
            100                 105     


<210>  55
<211>  106
<212>  PRT
<213>  Artificial Sequence

<220>  
<223>  06F11-V optimization variable domain VK sequence F11VK-123

<400>  55

Asp Ile Gln Met Thr Gln Ser Pro Ser Ser Leu Ser Ala Ser Val Gly 
1               5                   10                  15      


Asp Arg Val Thr Ile Thr Cys Gln Ala Ser Ser Ser Val Ser Phe Met 
            20                  25                  30          


Tyr Trp Tyr Gln Gln Arg Pro Gly Lys Ala Pro Arg Leu Leu Ile Tyr 
        35                  40                  45              


Asp Thr Ser Asn Leu Ala Ser Gly Val Pro Ser Arg Phe Ser Gly Ser 
    50                  55                  60                  


Gly Ser Gly Thr Ser Tyr Thr Phe Thr Ile Ser Ser Leu Gln Pro Glu 
65                  70                  75                  80  


Asp Ile Ala Thr Tyr Tyr Cys Gln Gln Trp Asp Thr Tyr Pro Leu Thr 
                85                  90                  95      


Phe Gly Gln Gly Thr Lys Val Glu Ile Lys 
            100                 105     


<210>  56
<211>  5
<212>  PRT
<213>  Artificial Sequence

<220>  
<223>  HCDR1

<400>  56

Ser Tyr Ala Met His 
1               5   


<210>  57
<211>  5
<212>  PRT
<213>  Artificial Sequence

<220>  
<223>  HCDR1

<400>  57

Ser Tyr Gly Met His 
1               5   


<210>  58
<211>  16
<212>  PRT
<213>  Artificial Sequence

<220>  
<223>  HCDR2

<400>  58

Ala Ile Trp Ser Gly Gly Ser Thr Asp Tyr Ala Ala Ser Val Lys Gly 
1               5                   10                  15      


<210>  59
<211>  16
<212>  PRT
<213>  Artificial Sequence

<220>  
<223>  HCDR2

<400>  59

Ala Ile Trp Ser Gly Gly Ser Thr Asp Tyr Ala Asp Ala Val Lys Gly 
1               5                   10                  15      


<210>  60
<211>  16
<212>  PRT
<213>  Artificial Sequence

<220>  
<223>  HCDR2

<400>  60

Val Ile Trp Ser Gly Gly Ser Thr Asp Tyr Ala Asp Ser Val Lys Gly 
1               5                   10                  15      


<210>  61
<211>  16
<212>  PRT
<213>  Artificial Sequence

<220>  
<223>  HCDR2

<400>  61

Val Ile Trp Ser Gly Gly Ser Thr Asp Tyr Ala Asp Ala Val Lys Gly 
1               5                   10                  15      


<210>  62
<211>  16
<212>  PRT
<213>  Artificial Sequence

<220>  
<223>  HCDR2

<400>  62

Val Ile Trp Ser Gly Gly Ser Thr Asp Tyr Asn Asp Ala Val Lys Gly 
1               5                   10                  15      


<210>  63
<211>  16
<212>  PRT
<213>  Artificial Sequence

<220>  
<223>  HCDR2

<400>  63

Ala Ile Trp Ser Gly Gly Ser Thr Asp Tyr Ala Ala Ala Val Lys Gly 
1               5                   10                  15      


<210>  64
<211>  16
<212>  PRT
<213>  Artificial Sequence

<220>  
<223>  HCDR2

<400>  64

Ala Ile Trp Ser Gly Gly Ser Thr Asp Tyr Ala Ala Thr Val Lys Gly 
1               5                   10                  15      


<210>  65
<211>  16
<212>  PRT
<213>  Artificial Sequence

<220>  
<223>  HCDR2

<400>  65

Ala Ile Trp Ser Gly Gly Ser Thr Asp Tyr Ala Asp Ser Val Lys Gly 
1               5                   10                  15      


<210>  66
<211>  16
<212>  PRT
<213>  Artificial Sequence

<220>  
<223>  HCDR2

<400>  66

Ala Ile Trp Ser Gly Gly Ser Thr Asp Tyr Asn Ala Ala Val Lys Gly 
1               5                   10                  15      


<210>  67
<211>  16
<212>  PRT
<213>  Artificial Sequence

<220>  
<223>  HCDR2

<400>  67

Ala Ile Trp Ser Gly Gly Ser Thr Asp Tyr Asn Ala Ser Val Lys Gly 
1               5                   10                  15      


<210>  68
<211>  16
<212>  PRT
<213>  Artificial Sequence

<220>  
<223>  HCDR2

<400>  68

Ala Ile Trp Ser Gly Gly Ser Thr Asp Tyr Asn Asp Ala Val Lys Gly 
1               5                   10                  15      


<210>  69
<211>  16
<212>  PRT
<213>  Artificial Sequence

<220>  
<223>  HCDR2

<400>  69

Ala Ile Trp Ser Gly Gly Ser Thr Asp Tyr Asn Asp Ser Val Lys Gly 
1               5                   10                  15      


<210>  70
<211>  16
<212>  PRT
<213>  Artificial Sequence

<220>  
<223>  HCDR2

<400>  70

Ala Ile Trp Ser Gly Gly Ser Thr Gln Tyr Asn Ala Ala Val Lys Gly 
1               5                   10                  15      


<210>  71
<211>  16
<212>  PRT
<213>  Artificial Sequence

<220>  
<223>  HCDR2

<400>  71

Ala Ile Trp Ser Gly Gly Ser Thr Tyr Tyr Ala Asp Ala Val Lys Gly 
1               5                   10                  15      


<210>  72
<211>  16
<212>  PRT
<213>  Artificial Sequence

<220>  
<223>  HCDR2

<400>  72

Ala Ile Trp Ser Gly Gly Ser Thr Tyr Tyr Asn Ala Ala Val Lys Gly 
1               5                   10                  15      


<210>  73
<211>  16
<212>  PRT
<213>  Artificial Sequence

<220>  
<223>  HCDR2

<400>  73

Ala Ile Trp Ser Gly Gly Ser Thr Tyr Tyr Asn Ala Ser Val Lys Gly 
1               5                   10                  15      


<210>  74
<211>  16
<212>  PRT
<213>  Artificial Sequence

<220>  
<223>  HCDR2

<400>  74

Ala Ile Trp Ser Gly Gly Ser Thr Tyr Tyr Asn Asp Ala Val Lys Gly 
1               5                   10                  15      


<210>  75
<211>  16
<212>  PRT
<213>  Artificial Sequence

<220>  
<223>  HCDR2

<400>  75

Ala Ile Tyr Ser Gly Gly Ser Thr Asp Tyr Ala Ala Ala Val Lys Gly 
1               5                   10                  15      


<210>  76
<211>  16
<212>  PRT
<213>  Artificial Sequence

<220>  
<223>  HCDR2

<400>  76

Ala Ile Tyr Ser Gly Gly Ser Thr Asp Tyr Ala Asp Ala Val Lys Gly 
1               5                   10                  15      


<210>  77
<211>  16
<212>  PRT
<213>  Artificial Sequence

<220>  
<223>  HCDR2

<400>  77

Ala Ile Tyr Ser Gly Gly Ser Thr Asp Tyr Asn Ala Ala Val Lys Gly 
1               5                   10                  15      


<210>  78
<211>  16
<212>  PRT
<213>  Artificial Sequence

<220>  
<223>  HCDR2

<400>  78

Ala Ile Tyr Ser Gly Gly Ser Thr Asp Tyr Asn Asp Ala Val Lys Gly 
1               5                   10                  15      


<210>  79
<211>  16
<212>  PRT
<213>  Artificial Sequence

<220>  
<223>  HCDR2

<400>  79

Ala Ile Tyr Ser Gly Gly Ser Thr Tyr Tyr Ala Ala Ser Val Lys Gly 
1               5                   10                  15      


<210>  80
<211>  16
<212>  PRT
<213>  Artificial Sequence

<220>  
<223>  HCDR2

<400>  80

Ala Ile Tyr Ser Gly Gly Ser Thr Tyr Tyr Ala Asp Ala Val Lys Gly 
1               5                   10                  15      


<210>  81
<211>  16
<212>  PRT
<213>  Artificial Sequence

<220>  
<223>  HCDR2

<400>  81

Ala Ile Tyr Ser Gly Gly Ser Thr Tyr Tyr Asn Asp Ala Val Lys Gly 
1               5                   10                  15      


<210>  82
<211>  16
<212>  PRT
<213>  Artificial Sequence

<220>  
<223>  HCDR2

<400>  82

Val Ile Trp Ser Gly Gly Ser Thr Asp Tyr Ala Ala Ala Val Lys Gly 
1               5                   10                  15      


<210>  83
<211>  16
<212>  PRT
<213>  Artificial Sequence

<220>  
<223>  HCDR2

<400>  83

Val Ile Trp Ser Gly Gly Ser Thr Asp Tyr Ala Ala Ser Val Lys Gly 
1               5                   10                  15      


<210>  84
<211>  16
<212>  PRT
<213>  Artificial Sequence

<220>  
<223>  HCDR2

<400>  84

Val Ile Trp Ser Gly Gly Ser Thr Asp Tyr Asn Ala Ala Val Lys Gly 
1               5                   10                  15      


<210>  85
<211>  16
<212>  PRT
<213>  Artificial Sequence

<220>  
<223>  HCDR2

<400>  85

Val Ile Trp Ser Gly Gly Ser Thr Asp Tyr Asn Ala Ser Val Lys Gly 
1               5                   10                  15      


<210>  86
<211>  16
<212>  PRT
<213>  Artificial Sequence

<220>  
<223>  HCDR2

<400>  86

Val Ile Trp Ser Gly Gly Ser Thr Asp Tyr Asn Asp Ser Val Lys Gly 
1               5                   10                  15      


<210>  87
<211>  16
<212>  PRT
<213>  Artificial Sequence

<220>  
<223>  HCDR2

<400>  87

Val Ile Trp Ser Gly Gly Ser Thr Tyr Tyr Asn Asp Ala Val Lys Gly 
1               5                   10                  15      


<210>  88
<211>  16
<212>  PRT
<213>  Artificial Sequence

<220>  
<223>  HCDR2

<400>  88

Val Ile Tyr Ser Gly Gly Ser Thr Asp Tyr Ala Ala Ser Val Lys Gly 
1               5                   10                  15      


<210>  89
<211>  16
<212>  PRT
<213>  Artificial Sequence

<220>  
<223>  HCDR2

<400>  89

Val Ile Tyr Ser Gly Gly Ser Thr Asp Tyr Ala Asp Ser Val Lys Gly 
1               5                   10                  15      


<210>  90
<211>  16
<212>  PRT
<213>  Artificial Sequence

<220>  
<223>  HCDR2

<400>  90

Val Ile Tyr Ser Gly Gly Ser Thr Asp Tyr Asn Asp Ala Val Lys Gly 
1               5                   10                  15      


<210>  91
<211>  16
<212>  PRT
<213>  Artificial Sequence

<220>  
<223>  HCDR2

<400>  91

Val Ile Tyr Ser Gly Gly Ser Thr Tyr Tyr Asn Ala Ala Val Lys Gly 
1               5                   10                  15      


<210>  92
<211>  11
<212>  PRT
<213>  Artificial Sequence

<220>  
<223>  HCDR3

<400>  92

Ala Gly Asp Tyr Glu Tyr Asp Gly Phe Ala Tyr 
1               5                   10      


<210>  93
<211>  11
<212>  PRT
<213>  Artificial Sequence

<220>  
<223>  HCDR3

<400>  93

Ala Gly Asp Lys Asn Tyr Asp Gly Phe Ala Tyr 
1               5                   10      


<210>  94
<211>  11
<212>  PRT
<213>  Artificial Sequence

<220>  
<223>  HCDR3

<400>  94

Ala Gly Asp Gln Asn Tyr Asp Gly Phe Ala Tyr 
1               5                   10      


<210>  95
<211>  11
<212>  PRT
<213>  Artificial Sequence

<220>  
<223>  HCDR3

<400>  95

Ala Gly Asp Glu Asn Tyr Asp Gly Phe Ala Tyr 
1               5                   10      


<210>  96
<211>  11
<212>  PRT
<213>  Artificial Sequence

<220>  
<223>  HCDR3

<400>  96

Ala Gly Asp His Asn Tyr Asp Gly Phe Ala Tyr 
1               5                   10      


<210>  97
<211>  11
<212>  PRT
<213>  Artificial Sequence

<220>  
<223>  HCDR3

<400>  97

Ala Gly Asp Met Asn Tyr Asp Gly Phe Ala Tyr 
1               5                   10      


<210>  98
<211>  11
<212>  PRT
<213>  Artificial Sequence

<220>  
<223>  HCDR3

<400>  98

Ala Gly Asp Asn Asn Tyr Asp Gly Phe Ala Tyr 
1               5                   10      


<210>  99
<211>  11
<212>  PRT
<213>  Artificial Sequence

<220>  
<223>  HCDR3

<400>  99

Ala Gly Asp Asn Asn Tyr Asp Gly Phe Glu Tyr 
1               5                   10      


<210>  100
<211>  11
<212>  PRT
<213>  Artificial Sequence

<220>  
<223>  HCDR3

<400>  100

Ala Gly Asp Tyr Asp Tyr Asp Gly Phe Ala Tyr 
1               5                   10      


<210>  101
<211>  11
<212>  PRT
<213>  Artificial Sequence

<220>  
<223>  HCDR3

<400>  101

Ala Gly Asp Tyr Asn Leu Asp Gly Phe Ala Tyr 
1               5                   10      


<210>  102
<211>  11
<212>  PRT
<213>  Artificial Sequence

<220>  
<223>  HCDR3

<400>  102

Ala Gly Asp Tyr Asn Trp Asp Gly Phe Ala Tyr 
1               5                   10      


<210>  103
<211>  11
<212>  PRT
<213>  Artificial Sequence

<220>  
<223>  HCDR3

<400>  103

Ala Gly Asp Tyr Asn Tyr Asp Gly Phe Ala Ile 
1               5                   10      


<210>  104
<211>  11
<212>  PRT
<213>  Artificial Sequence

<220>  
<223>  HCDR3

<400>  104

Ala Gly Asp Tyr Asn Tyr Asp Gly Phe Ala Met 
1               5                   10      


<210>  105
<211>  11
<212>  PRT
<213>  Artificial Sequence

<220>  
<223>  HCDR3

<400>  105

Ala Gly Asp Tyr Asn Tyr Asp Gly Phe Ala Asn 
1               5                   10      


<210>  106
<211>  11
<212>  PRT
<213>  Artificial Sequence

<220>  
<223>  HCDR3

<400>  106

Ala Gly Asp Tyr Asn Tyr Asp Gly Phe Ala Trp 
1               5                   10      


<210>  107
<211>  11
<212>  PRT
<213>  Artificial Sequence

<220>  
<223>  HCDR3

<400>  107

Ala Gly Asp Tyr Asn Tyr Asp Gly Phe Arg Tyr 
1               5                   10      


<210>  108
<211>  11
<212>  PRT
<213>  Artificial Sequence

<220>  
<223>  HCDR3

<400>  108

Ala Gly Asp Tyr Asn Tyr Asp Gly Leu Ala Tyr 
1               5                   10      


<210>  109
<211>  11
<212>  PRT
<213>  Artificial Sequence

<220>  
<223>  HCDR3

<400>  109

Ala Gly Asn Tyr Asn Tyr Asp Gly Phe Ala Tyr 
1               5                   10      


<210>  110
<211>  11
<212>  PRT
<213>  Artificial Sequence

<220>  
<223>  HCDR3

<400>  110

Ala Gly Pro Tyr Asn Tyr Asp Gly Phe Ala Tyr 
1               5                   10      


<210>  111
<211>  11
<212>  PRT
<213>  Artificial Sequence

<220>  
<223>  HCDR3

<400>  111

Ala Gly Thr Tyr Asn Tyr Asp Gly Phe Ala Tyr 
1               5                   10      


<210>  112
<211>  10
<212>  PRT
<213>  Artificial Sequence

<220>  
<223>  LCDR1

<400>  112

Gln Ala Ser Gln Asp Ile Ser Phe Met Tyr 
1               5                   10  


<210>  113
<211>  10
<212>  PRT
<213>  Artificial Sequence

<220>  
<223>  LCDR1

<400>  113

Gln Ala Ser Gln Ser Val Ser His Leu Tyr 
1               5                   10  


<210>  114
<211>  10
<212>  PRT
<213>  Artificial Sequence

<220>  
<223>  LCDR1

<400>  114

Gln Ala Ser Gln Ser Val Ser Tyr Met Tyr 
1               5                   10  


<210>  115
<211>  10
<212>  PRT
<213>  Artificial Sequence

<220>  
<223>  LCDR1

<400>  115

Gln Ala Ser Ser Ser Ile Ser Phe Met Tyr 
1               5                   10  


<210>  116
<211>  10
<212>  PRT
<213>  Artificial Sequence

<220>  
<223>  LCDR1

<400>  116

Gln Ala Ser Ser Ser Ile Ser Tyr Met Tyr 
1               5                   10  


<210>  117
<211>  10
<212>  PRT
<213>  Artificial Sequence

<220>  
<223>  LCDR1

<400>  117

Gln Ala Ser Ser Ser Val Ser His Met Tyr 
1               5                   10  


<210>  118
<211>  10
<212>  PRT
<213>  Artificial Sequence

<220>  
<223>  LCDR1

<400>  118

Gln Ala Ser Gln Ser Ile Ser Phe Leu Tyr 
1               5                   10  


<210>  119
<211>  10
<212>  PRT
<213>  Artificial Sequence

<220>  
<223>  LCDR1

<400>  119

Gln Ala Ser Gln Ser Ile Ser His Leu Tyr 
1               5                   10  


<210>  120
<211>  10
<212>  PRT
<213>  Artificial Sequence

<220>  
<223>  LCDR1

<400>  120

Gln Ala Ser Gln Ser Ile Ser His Met Tyr 
1               5                   10  


<210>  121
<211>  10
<212>  PRT
<213>  Artificial Sequence

<220>  
<223>  LCDR1

<400>  121

Gln Ala Ser Ser Asp Ile Ser His Leu Tyr 
1               5                   10  


<210>  122
<211>  10
<212>  PRT
<213>  Artificial Sequence

<220>  
<223>  LCDR1

<400>  122

Gln Ala Ser Ser Ser Val Ser His Leu Tyr 
1               5                   10  


<210>  123
<211>  10
<212>  PRT
<213>  Artificial Sequence

<220>  
<223>  LCDR1

<400>  123

Gln Ala Ser Gln Ser Ile Ser Tyr Met Tyr 
1               5                   10  


<210>  124
<211>  10
<212>  PRT
<213>  Artificial Sequence

<220>  
<223>  LCDR1

<400>  124

Gln Ala Ser Gln Asp Ile Ser His Leu Tyr 
1               5                   10  


<210>  125
<211>  10
<212>  PRT
<213>  Artificial Sequence

<220>  
<223>  LCDR1

<400>  125

Gln Ala Ser Gln Asp Ile Ser Tyr Leu Tyr 
1               5                   10  


<210>  126
<211>  10
<212>  PRT
<213>  Artificial Sequence

<220>  
<223>  LCDR1

<400>  126

Gln Ala Ser Gln Asp Ile Ser Tyr Met Tyr 
1               5                   10  


<210>  127
<211>  10
<212>  PRT
<213>  Artificial Sequence

<220>  
<223>  LCDR1

<400>  127

Gln Ala Ser Gln Asp Val Ser Phe Leu Tyr 
1               5                   10  


<210>  128
<211>  10
<212>  PRT
<213>  Artificial Sequence

<220>  
<223>  LCDR1

<400>  128

Gln Ala Ser Gln Asp Val Ser His Leu Asn 
1               5                   10  


<210>  129
<211>  10
<212>  PRT
<213>  Artificial Sequence

<220>  
<223>  LCDR1

<400>  129

Gln Ala Ser Gln Asp Val Ser His Leu Tyr 
1               5                   10  


<210>  130
<211>  10
<212>  PRT
<213>  Artificial Sequence

<220>  
<223>  LCDR1

<400>  130

Gln Ala Ser Gln Asp Val Ser His Met Tyr 
1               5                   10  


<210>  131
<211>  10
<212>  PRT
<213>  Artificial Sequence

<220>  
<223>  LCDR1

<400>  131

Gln Ala Ser Gln Asp Val Ser Tyr Leu Tyr 
1               5                   10  


<210>  132
<211>  10
<212>  PRT
<213>  Artificial Sequence

<220>  
<223>  LCDR1

<400>  132

Gln Ala Ser Gln Asp Val Ser Tyr Met Tyr 
1               5                   10  


<210>  133
<211>  10
<212>  PRT
<213>  Artificial Sequence

<220>  
<223>  LCDR1

<400>  133

Gln Ala Ser Gln Ser Ile Ser Phe Met Tyr 
1               5                   10  


<210>  134
<211>  10
<212>  PRT
<213>  Artificial Sequence

<220>  
<223>  LCDR1

<400>  134

Gln Ala Ser Gln Ser Val Arg His Met Tyr 
1               5                   10  


<210>  135
<211>  10
<212>  PRT
<213>  Artificial Sequence

<220>  
<223>  LCDR1

<400>  135

Gln Ala Ser Gln Ser Val Ser Phe Met Tyr 
1               5                   10  


<210>  136
<211>  10
<212>  PRT
<213>  Artificial Sequence

<220>  
<223>  LCDR1

<400>  136

Gln Ala Ser Gln Ser Val Ser His Met Tyr 
1               5                   10  


<210>  137
<211>  10
<212>  PRT
<213>  Artificial Sequence

<220>  
<223>  LCDR1

<400>  137

Gln Ala Ser Gln Ser Val Ser Tyr Leu Tyr 
1               5                   10  


<210>  138
<211>  10
<212>  PRT
<213>  Artificial Sequence

<220>  
<223>  LCDR1

<400>  138

Gln Ala Ser Ser Asp Ile Ser Phe Met Tyr 
1               5                   10  


<210>  139
<211>  10
<212>  PRT
<213>  Artificial Sequence

<220>  
<223>  LCDR1

<400>  139

Gln Ala Ser Ser Asp Ile Ser Tyr Met Tyr 
1               5                   10  


<210>  140
<211>  10
<212>  PRT
<213>  Artificial Sequence

<220>  
<223>  LCDR1

<400>  140

Gln Ala Ser Ser Asp Val Ser Phe Leu Tyr 
1               5                   10  


<210>  141
<211>  10
<212>  PRT
<213>  Artificial Sequence

<220>  
<223>  LCDR1

<400>  141

Gln Ala Ser Ser Asp Val Ser Phe Met Tyr 
1               5                   10  


<210>  142
<211>  10
<212>  PRT
<213>  Artificial Sequence

<220>  
<223>  LCDR1

<400>  142

Gln Ala Ser Ser Asp Val Ser His Leu Tyr 
1               5                   10  


<210>  143
<211>  10
<212>  PRT
<213>  Artificial Sequence

<220>  
<223>  LCDR1

<400>  143

Gln Ala Ser Ser Asp Val Ser His Met Tyr 
1               5                   10  


<210>  144
<211>  10
<212>  PRT
<213>  Artificial Sequence

<220>  
<223>  LCDR1

<400>  144

Gln Ala Ser Ser Asp Val Ser Tyr Met Tyr 
1               5                   10  


<210>  145
<211>  10
<212>  PRT
<213>  Artificial Sequence

<220>  
<223>  LCDR1

<400>  145

Gln Ala Ser Ser Ser Ile Ser Phe Leu Tyr 
1               5                   10  


<210>  146
<211>  10
<212>  PRT
<213>  Artificial Sequence

<220>  
<223>  LCDR1

<400>  146

Gln Ala Ser Ser Ser Ile Ser His Leu Tyr 
1               5                   10  


<210>  147
<211>  10
<212>  PRT
<213>  Artificial Sequence

<220>  
<223>  LCDR1

<400>  147

Gln Ala Ser Ser Ser Ile Ser Tyr Leu Tyr 
1               5                   10  


<210>  148
<211>  10
<212>  PRT
<213>  Artificial Sequence

<220>  
<223>  LCDR1

<400>  148

Gln Ala Ser Ser Ser Val Ser Tyr Met Tyr 
1               5                   10  


<210>  149
<211>  7
<212>  PRT
<213>  Artificial Sequence

<220>  
<223>  LCDR2

<400>  149

Asp Ala Ser Asn Leu Ala Thr 
1               5           


<210>  150
<211>  7
<212>  PRT
<213>  Artificial Sequence

<220>  
<223>  LCDR2

<400>  150

Asp Thr Ser Asn Leu Ala Thr 
1               5           


<210>  151
<211>  7
<212>  PRT
<213>  Artificial Sequence

<220>  
<223>  LCDR2

<400>  151

Asp Thr Ser Asn Leu Glu Thr 
1               5           


<210>  152
<211>  7
<212>  PRT
<213>  Artificial Sequence

<220>  
<223>  LCDR2

<400>  152

Asp Ala Ser Asn Leu Glu Thr 
1               5           


<210>  153
<211>  9
<212>  PRT
<213>  Artificial Sequence

<220>  
<223>  LCDR3

<400>  153

Gln Gln Trp Asp Asn Tyr Pro Leu Thr 
1               5                   


<210>  154
<211>  9
<212>  PRT
<213>  Artificial Sequence

<220>  
<223>  LCDR3

<400>  154

Gln Gln Trp Asp Thr Tyr Pro Leu Thr 
1               5                   


<210>  155
<211>  9
<212>  PRT
<213>  Artificial Sequence

<220>  
<223>  LCDR3

<400>  155

Gln Gln Trp Ser Asn Tyr Pro Leu Thr 
1               5                   


<210>  156
<211>  9
<212>  PRT
<213>  Artificial Sequence

<220>  
<223>  LCDR3

<400>  156

Gln Gln Trp Asp Asn Leu Pro Leu Thr 
1               5                   


<210>  157
<211>  9
<212>  PRT
<213>  Artificial Sequence

<220>  
<223>  LCDR3

<400>  157

Gln Gln Trp Asp Thr Leu Pro Leu Thr 
1               5                   


<210>  158
<211>  9
<212>  PRT
<213>  Artificial Sequence

<220>  
<223>  LCDR3

<400>  158

Gln Gln Trp Ser Asn Leu Pro Leu Thr 
1               5                   


<210>  159
<211>  9
<212>  PRT
<213>  Artificial Sequence

<220>  
<223>  LCDR3

<400>  159

Gln Gln Trp Ser Thr Leu Pro Leu Thr 
1               5                   


<210>  160
<211>  7
<212>  PRT
<213>  Artificial Sequence

<220>  
<223>  HCDR3


<220>
<221>  MISC_FEATURE
<222>  (1)..(1)
<223>  Xaa is Gln or any other amino acid

<220>
<221>  MISC_FEATURE
<222>  (2)..(2)
<223>  Xaa is Leu or any other amino acid

<220>
<221>  MISC_FEATURE
<222>  (3)..(3)
<223>  Xaa is Tyr or a conservative substitution or Tyr

<220>
<221>  MISC_FEATURE
<222>  (4)..(4)
<223>  Xaa is Tyr or any other amino acid

<220>
<221>  MISC_FEATURE
<222>  (5)..(5)
<223>  Xaa is Phe or any other amino acid

<400>  160

Xaa Xaa Xaa Xaa Xaa Asp Tyr 
1               5           


<210>  161
<211>  11
<212>  PRT
<213>  Artificial Sequence

<220>  
<223>  LCDR1


<220>
<221>  MISC_FEATURE
<222>  (7)..(8)
<223>  Xaa is Ser or a conservative substitution of Ser

<220>
<221>  MISC_FEATURE
<222>  (9)..(9)
<223>  Xaa is Tyr or a conservative substitution of Tyr

<220>
<221>  MISC_FEATURE
<222>  (10)..(10)
<223>  Xaa is Leu or a conservative substitution of Leu

<220>
<221>  MISC_FEATURE
<222>  (11)..(11)
<223>  Xaa is Asn or Thr or a conservative substitution of Asn or Thr

<400>  161

Arg Ala Ser Gln Ser Ile Xaa Xaa Xaa Xaa Xaa 
1               5                   10      


<210>  162
<211>  7
<212>  PRT
<213>  Artificial Sequence

<220>  
<223>  LCDR2


<220>
<221>  MISC_FEATURE
<222>  (1)..(1)
<223>  Xaa is Ala or Thr or a conservative substitution of Ala or Thr

<220>
<221>  MISC_FEATURE
<222>  (3)..(3)
<223>  Xaa is Ser or a conservative substitution of Ser

<220>
<221>  MISC_FEATURE
<222>  (6)..(6)
<223>  Xaa is Gln or any other amino acid

<220>
<221>  MISC_FEATURE
<222>  (7)..(7)
<223>  Xaa is Ser or any other amino acid

<400>  162

Xaa Ala Xaa Ser Leu Xaa Xaa 
1               5           


<210>  163
<211>  9
<212>  PRT
<213>  Artificial Sequence

<220>  
<223>  LCDR3


<220>
<221>  MISC_FEATURE
<222>  (3)..(3)
<223>  Xaa is Ser or any other amino acid

<220>
<221>  MISC_FEATURE
<222>  (6)..(6)
<223>  Xaa is Thr or any other amino acid

<220>
<221>  MISC_FEATURE
<222>  (8)..(8)
<223>  Xaa is Trp or any other amino acid

<400>  163

Gln Gln Xaa Tyr Ser Xaa Pro Xaa Thr 
1               5                   


