                         SEQUENCE LISTING

<110>  MEMORIAL SLOAN KETTERING CANCER CENTER
       Panjwani & Hsu
 
<120>  ENGINEERED HLA MOLECULES USEFUL FOR T CELL AND NK CELL ACTIVATION
        AND EXPANSION

<130>  MSKCC_053_WO1

<160>  50    

<170>  PatentIn version 3.5

<210>  1
<211>  361
<212>  PRT
<213>  Homo sapiens

<400>  1

Met Val Val Met Ala Pro Arg Thr Leu Phe Leu Leu Leu Ser Gly Ala 
1               5                   10                  15      


Leu Thr Leu Thr Glu Thr Trp Ala Gly Ser His Ser Leu Lys Tyr Phe 
            20                  25                  30          


His Thr Ser Val Ser Arg Pro Gly Arg Gly Glu Pro Arg Phe Ile Ser 
        35                  40                  45              


Val Gly Tyr Val Asp Asp Thr Gln Phe Val Arg Phe Asp Asn Asp Ala 
    50                  55                  60                  


Ala Ser Pro Arg Met Val Pro Arg Ala Pro Trp Met Glu Gln Glu Gly 
65                  70                  75                  80  


Ser Glu Tyr Trp Asp Arg Glu Thr Arg Ser Ala Arg Asp Thr Ala Gln 
                85                  90                  95      


Ile Phe Arg Val Asn Leu Arg Thr Leu Arg Gly Tyr Tyr Asn Gln Ser 
            100                 105                 110         


Glu Ala Gly Ser His Thr Leu Gln Trp Met His Gly Cys Glu Leu Gly 
        115                 120                 125             


Pro Asp Gly Arg Phe Leu Arg Gly Tyr Glu Gln Phe Ala Tyr Asp Gly 
    130                 135                 140                 


Lys Asp Tyr Leu Thr Leu Asn Glu Asp Leu Arg Ser Trp Thr Ala Val 
145                 150                 155                 160 


Asp Thr Ala Ala Gln Ile Ser Glu Gln Lys Ser Asn Asp Ala Ser Glu 
                165                 170                 175     


Ala Glu His Gln Arg Ala Tyr Leu Glu Asp Thr Cys Val Glu Trp Leu 
            180                 185                 190         


His Lys Tyr Leu Glu Lys Gly Lys Glu Thr Leu Leu His Leu Glu Pro 
        195                 200                 205             


Pro Lys Thr His Val Thr His His Pro Ile Ser Asp His Glu Ala Thr 
    210                 215                 220                 


Leu Arg Cys Trp Ala Leu Gly Phe Tyr Pro Ala Glu Ile Thr Leu Thr 
225                 230                 235                 240 


Trp Gln Gln Asp Gly Glu Gly His Thr Gln Asp Thr Glu Leu Val Glu 
                245                 250                 255     


Thr Arg Pro Ala Gly Asp Gly Thr Phe Gln Lys Trp Ala Ala Val Val 
            260                 265                 270         


Val Pro Ser Gly Glu Glu Gln Arg Tyr Thr Cys His Val Gln His Glu 
        275                 280                 285             


Gly Leu Pro Glu Pro Val Thr Leu Arg Trp Lys Pro Ala Ser Gln Pro 
    290                 295                 300                 


Thr Ile Pro Ile Val Gly Ile Ile Ala Gly Leu Val Leu Leu Gly Ser 
305                 310                 315                 320 


Val Val Ser Gly Ala Val Val Ala Ala Val Ile Trp Arg Lys Lys Ser 
                325                 330                 335     


Ser Gly Gly Lys Gly Gly Ser Tyr Ser Lys Ala Glu Trp Ser Asp Ser 
            340                 345                 350         


Ala Gln Gly Ser Glu Ser His Ser Leu 
        355                 360     


<210>  2
<211>  361
<212>  PRT
<213>  Homo sapiens

<400>  2

Met Ala Val Met Ala Pro Arg Thr Leu Leu Leu Leu Leu Ser Gly Ala 
1               5                   10                  15      


Leu Ala Leu Thr Gln Thr Trp Ala Gly Ser His Ser Leu Lys Tyr Phe 
            20                  25                  30          


His Thr Ser Val Ser Arg Pro Gly Arg Gly Glu Pro Arg Phe Ile Ser 
        35                  40                  45              


Val Gly Tyr Val Asp Asp Thr Gln Phe Val Arg Phe Asp Asn Asp Ala 
    50                  55                  60                  


Ala Ser Pro Arg Met Val Pro Arg Ala Pro Trp Met Glu Gln Glu Gly 
65                  70                  75                  80  


Ser Glu Tyr Trp Asp Arg Glu Thr Arg Ser Ala Arg Asp Thr Ala Gln 
                85                  90                  95      


Ile Phe Arg Val Asn Leu Arg Thr Leu Arg Gly Tyr Tyr Asn Gln Ser 
            100                 105                 110         


Glu Ala Gly Ser His Thr Leu Gln Trp Met His Gly Cys Glu Leu Gly 
        115                 120                 125             


Pro Asp Gly Arg Phe Leu Arg Gly Tyr Glu Gln Phe Ala Tyr Asp Gly 
    130                 135                 140                 


Lys Asp Tyr Leu Thr Leu Asn Glu Asp Leu Arg Ser Trp Thr Ala Val 
145                 150                 155                 160 


Asp Thr Ala Ala Gln Ile Ser Glu Gln Lys Ser Asn Asp Ala Ser Glu 
                165                 170                 175     


Ala Glu His Gln Arg Ala Tyr Leu Glu Asp Thr Cys Val Glu Trp Leu 
            180                 185                 190         


His Lys Tyr Leu Glu Lys Gly Lys Glu Thr Leu Leu His Leu Glu Pro 
        195                 200                 205             


Pro Lys Thr His Val Thr His His Pro Ile Ser Asp His Glu Ala Thr 
    210                 215                 220                 


Leu Arg Cys Trp Ala Leu Gly Phe Tyr Pro Ala Glu Ile Thr Leu Thr 
225                 230                 235                 240 


Trp Gln Gln Asp Gly Glu Gly His Thr Gln Asp Thr Glu Leu Val Glu 
                245                 250                 255     


Thr Arg Pro Ala Gly Asp Gly Thr Phe Gln Lys Trp Ala Ala Val Val 
            260                 265                 270         


Val Pro Ser Gly Glu Glu Gln Arg Tyr Thr Cys His Val Gln His Glu 
        275                 280                 285             


Gly Leu Pro Glu Pro Val Thr Leu Arg Trp Lys Pro Ala Ser Gln Pro 
    290                 295                 300                 


Thr Ile Pro Ile Val Gly Ile Ile Ala Gly Leu Val Leu Leu Gly Ser 
305                 310                 315                 320 


Val Val Ser Gly Ala Val Val Ala Ala Val Ile Trp Arg Lys Lys Ser 
                325                 330                 335     


Ser Gly Gly Lys Gly Gly Ser Tyr Ser Lys Ala Glu Trp Ser Asp Ser 
            340                 345                 350         


Ala Gln Gly Ser Glu Ser His Ser Leu 
        355                 360     


<210>  3
<211>  361
<212>  PRT
<213>  Homo sapiens

<400>  3

Met Ala Val Met Ala Pro Arg Thr Leu Val Leu Leu Leu Ser Gly Ala 
1               5                   10                  15      


Leu Ala Leu Thr Gln Thr Trp Ala Gly Ser His Ser Leu Lys Tyr Phe 
            20                  25                  30          


His Thr Ser Val Ser Arg Pro Gly Arg Gly Glu Pro Arg Phe Ile Ser 
        35                  40                  45              


Val Gly Tyr Val Asp Asp Thr Gln Phe Val Arg Phe Asp Asn Asp Ala 
    50                  55                  60                  


Ala Ser Pro Arg Met Val Pro Arg Ala Pro Trp Met Glu Gln Glu Gly 
65                  70                  75                  80  


Ser Glu Tyr Trp Asp Arg Glu Thr Arg Ser Ala Arg Asp Thr Ala Gln 
                85                  90                  95      


Ile Phe Arg Val Asn Leu Arg Thr Leu Arg Gly Tyr Tyr Asn Gln Ser 
            100                 105                 110         


Glu Ala Gly Ser His Thr Leu Gln Trp Met His Gly Cys Glu Leu Gly 
        115                 120                 125             


Pro Asp Gly Arg Phe Leu Arg Gly Tyr Glu Gln Phe Ala Tyr Asp Gly 
    130                 135                 140                 


Lys Asp Tyr Leu Thr Leu Asn Glu Asp Leu Arg Ser Trp Thr Ala Val 
145                 150                 155                 160 


Asp Thr Ala Ala Gln Ile Ser Glu Gln Lys Ser Asn Asp Ala Ser Glu 
                165                 170                 175     


Ala Glu His Gln Arg Ala Tyr Leu Glu Asp Thr Cys Val Glu Trp Leu 
            180                 185                 190         


His Lys Tyr Leu Glu Lys Gly Lys Glu Thr Leu Leu His Leu Glu Pro 
        195                 200                 205             


Pro Lys Thr His Val Thr His His Pro Ile Ser Asp His Glu Ala Thr 
    210                 215                 220                 


Leu Arg Cys Trp Ala Leu Gly Phe Tyr Pro Ala Glu Ile Thr Leu Thr 
225                 230                 235                 240 


Trp Gln Gln Asp Gly Glu Gly His Thr Gln Asp Thr Glu Leu Val Glu 
                245                 250                 255     


Thr Arg Pro Ala Gly Asp Gly Thr Phe Gln Lys Trp Ala Ala Val Val 
            260                 265                 270         


Val Pro Ser Gly Glu Glu Gln Arg Tyr Thr Cys His Val Gln His Glu 
        275                 280                 285             


Gly Leu Pro Glu Pro Val Thr Leu Arg Trp Lys Pro Ala Ser Gln Pro 
    290                 295                 300                 


Thr Ile Pro Ile Val Gly Ile Ile Ala Gly Leu Val Leu Leu Gly Ser 
305                 310                 315                 320 


Val Val Ser Gly Ala Val Val Ala Ala Val Ile Trp Arg Lys Lys Ser 
                325                 330                 335     


Ser Gly Gly Lys Gly Gly Ser Tyr Ser Lys Ala Glu Trp Ser Asp Ser 
            340                 345                 350         


Ala Gln Gly Ser Glu Ser His Ser Leu 
        355                 360     


<210>  4
<211>  361
<212>  PRT
<213>  Homo sapiens

<400>  4

Met Ala Val Met Ala Pro Arg Thr Leu Leu Leu Leu Leu Leu Gly Ala 
1               5                   10                  15      


Leu Ala Leu Thr Gln Thr Trp Ala Gly Ser His Ser Leu Lys Tyr Phe 
            20                  25                  30          


His Thr Ser Val Ser Arg Pro Gly Arg Gly Glu Pro Arg Phe Ile Ser 
        35                  40                  45              


Val Gly Tyr Val Asp Asp Thr Gln Phe Val Arg Phe Asp Asn Asp Ala 
    50                  55                  60                  


Ala Ser Pro Arg Met Val Pro Arg Ala Pro Trp Met Glu Gln Glu Gly 
65                  70                  75                  80  


Ser Glu Tyr Trp Asp Arg Glu Thr Arg Ser Ala Arg Asp Thr Ala Gln 
                85                  90                  95      


Ile Phe Arg Val Asn Leu Arg Thr Leu Arg Gly Tyr Tyr Asn Gln Ser 
            100                 105                 110         


Glu Ala Gly Ser His Thr Leu Gln Trp Met His Gly Cys Glu Leu Gly 
        115                 120                 125             


Pro Asp Gly Arg Phe Leu Arg Gly Tyr Glu Gln Phe Ala Tyr Asp Gly 
    130                 135                 140                 


Lys Asp Tyr Leu Thr Leu Asn Glu Asp Leu Arg Ser Trp Thr Ala Val 
145                 150                 155                 160 


Asp Thr Ala Ala Gln Ile Ser Glu Gln Lys Ser Asn Asp Ala Ser Glu 
                165                 170                 175     


Ala Glu His Gln Arg Ala Tyr Leu Glu Asp Thr Cys Val Glu Trp Leu 
            180                 185                 190         


His Lys Tyr Leu Glu Lys Gly Lys Glu Thr Leu Leu His Leu Glu Pro 
        195                 200                 205             


Pro Lys Thr His Val Thr His His Pro Ile Ser Asp His Glu Ala Thr 
    210                 215                 220                 


Leu Arg Cys Trp Ala Leu Gly Phe Tyr Pro Ala Glu Ile Thr Leu Thr 
225                 230                 235                 240 


Trp Gln Gln Asp Gly Glu Gly His Thr Gln Asp Thr Glu Leu Val Glu 
                245                 250                 255     


Thr Arg Pro Ala Gly Asp Gly Thr Phe Gln Lys Trp Ala Ala Val Val 
            260                 265                 270         


Val Pro Ser Gly Glu Glu Gln Arg Tyr Thr Cys His Val Gln His Glu 
        275                 280                 285             


Gly Leu Pro Glu Pro Val Thr Leu Arg Trp Lys Pro Ala Ser Gln Pro 
    290                 295                 300                 


Thr Ile Pro Ile Val Gly Ile Ile Ala Gly Leu Val Leu Leu Gly Ser 
305                 310                 315                 320 


Val Val Ser Gly Ala Val Val Ala Ala Val Ile Trp Arg Lys Lys Ser 
                325                 330                 335     


Ser Gly Gly Lys Gly Gly Ser Tyr Ser Lys Ala Glu Trp Ser Asp Ser 
            340                 345                 350         


Ala Gln Gly Ser Glu Ser His Ser Leu 
        355                 360     


<210>  5
<211>  361
<212>  PRT
<213>  Homo sapiens

<400>  5

Met Ala Ile Met Ala Pro Arg Thr Leu Val Leu Leu Leu Ser Gly Ala 
1               5                   10                  15      


Leu Ala Leu Thr Gln Thr Trp Ala Gly Ser His Ser Leu Lys Tyr Phe 
            20                  25                  30          


His Thr Ser Val Ser Arg Pro Gly Arg Gly Glu Pro Arg Phe Ile Ser 
        35                  40                  45              


Val Gly Tyr Val Asp Asp Thr Gln Phe Val Arg Phe Asp Asn Asp Ala 
    50                  55                  60                  


Ala Ser Pro Arg Met Val Pro Arg Ala Pro Trp Met Glu Gln Glu Gly 
65                  70                  75                  80  


Ser Glu Tyr Trp Asp Arg Glu Thr Arg Ser Ala Arg Asp Thr Ala Gln 
                85                  90                  95      


Ile Phe Arg Val Asn Leu Arg Thr Leu Arg Gly Tyr Tyr Asn Gln Ser 
            100                 105                 110         


Glu Ala Gly Ser His Thr Leu Gln Trp Met His Gly Cys Glu Leu Gly 
        115                 120                 125             


Pro Asp Gly Arg Phe Leu Arg Gly Tyr Glu Gln Phe Ala Tyr Asp Gly 
    130                 135                 140                 


Lys Asp Tyr Leu Thr Leu Asn Glu Asp Leu Arg Ser Trp Thr Ala Val 
145                 150                 155                 160 


Asp Thr Ala Ala Gln Ile Ser Glu Gln Lys Ser Asn Asp Ala Ser Glu 
                165                 170                 175     


Ala Glu His Gln Arg Ala Tyr Leu Glu Asp Thr Cys Val Glu Trp Leu 
            180                 185                 190         


His Lys Tyr Leu Glu Lys Gly Lys Glu Thr Leu Leu His Leu Glu Pro 
        195                 200                 205             


Pro Lys Thr His Val Thr His His Pro Ile Ser Asp His Glu Ala Thr 
    210                 215                 220                 


Leu Arg Cys Trp Ala Leu Gly Phe Tyr Pro Ala Glu Ile Thr Leu Thr 
225                 230                 235                 240 


Trp Gln Gln Asp Gly Glu Gly His Thr Gln Asp Thr Glu Leu Val Glu 
                245                 250                 255     


Thr Arg Pro Ala Gly Asp Gly Thr Phe Gln Lys Trp Ala Ala Val Val 
            260                 265                 270         


Val Pro Ser Gly Glu Glu Gln Arg Tyr Thr Cys His Val Gln His Glu 
        275                 280                 285             


Gly Leu Pro Glu Pro Val Thr Leu Arg Trp Lys Pro Ala Ser Gln Pro 
    290                 295                 300                 


Thr Ile Pro Ile Val Gly Ile Ile Ala Gly Leu Val Leu Leu Gly Ser 
305                 310                 315                 320 


Val Val Ser Gly Ala Val Val Ala Ala Val Ile Trp Arg Lys Lys Ser 
                325                 330                 335     


Ser Gly Gly Lys Gly Gly Ser Tyr Ser Lys Ala Glu Trp Ser Asp Ser 
            340                 345                 350         


Ala Gln Gly Ser Glu Ser His Ser Leu 
        355                 360     


<210>  6
<211>  361
<212>  PRT
<213>  Homo sapiens

<400>  6

Met Leu Val Met Ala Pro Arg Thr Val Leu Leu Leu Leu Ser Ala Ala 
1               5                   10                  15      


Leu Ala Leu Thr Glu Thr Trp Ala Gly Ser His Ser Leu Lys Tyr Phe 
            20                  25                  30          


His Thr Ser Val Ser Arg Pro Gly Arg Gly Glu Pro Arg Phe Ile Ser 
        35                  40                  45              


Val Gly Tyr Val Asp Asp Thr Gln Phe Val Arg Phe Asp Asn Asp Ala 
    50                  55                  60                  


Ala Ser Pro Arg Met Val Pro Arg Ala Pro Trp Met Glu Gln Glu Gly 
65                  70                  75                  80  


Ser Glu Tyr Trp Asp Arg Glu Thr Arg Ser Ala Arg Asp Thr Ala Gln 
                85                  90                  95      


Ile Phe Arg Val Asn Leu Arg Thr Leu Arg Gly Tyr Tyr Asn Gln Ser 
            100                 105                 110         


Glu Ala Gly Ser His Thr Leu Gln Trp Met His Gly Cys Glu Leu Gly 
        115                 120                 125             


Pro Asp Gly Arg Phe Leu Arg Gly Tyr Glu Gln Phe Ala Tyr Asp Gly 
    130                 135                 140                 


Lys Asp Tyr Leu Thr Leu Asn Glu Asp Leu Arg Ser Trp Thr Ala Val 
145                 150                 155                 160 


Asp Thr Ala Ala Gln Ile Ser Glu Gln Lys Ser Asn Asp Ala Ser Glu 
                165                 170                 175     


Ala Glu His Gln Arg Ala Tyr Leu Glu Asp Thr Cys Val Glu Trp Leu 
            180                 185                 190         


His Lys Tyr Leu Glu Lys Gly Lys Glu Thr Leu Leu His Leu Glu Pro 
        195                 200                 205             


Pro Lys Thr His Val Thr His His Pro Ile Ser Asp His Glu Ala Thr 
    210                 215                 220                 


Leu Arg Cys Trp Ala Leu Gly Phe Tyr Pro Ala Glu Ile Thr Leu Thr 
225                 230                 235                 240 


Trp Gln Gln Asp Gly Glu Gly His Thr Gln Asp Thr Glu Leu Val Glu 
                245                 250                 255     


Thr Arg Pro Ala Gly Asp Gly Thr Phe Gln Lys Trp Ala Ala Val Val 
            260                 265                 270         


Val Pro Ser Gly Glu Glu Gln Arg Tyr Thr Cys His Val Gln His Glu 
        275                 280                 285             


Gly Leu Pro Glu Pro Val Thr Leu Arg Trp Lys Pro Ala Ser Gln Pro 
    290                 295                 300                 


Thr Ile Pro Ile Val Gly Ile Ile Ala Gly Leu Val Leu Leu Gly Ser 
305                 310                 315                 320 


Val Val Ser Gly Ala Val Val Ala Ala Val Ile Trp Arg Lys Lys Ser 
                325                 330                 335     


Ser Gly Gly Lys Gly Gly Ser Tyr Ser Lys Ala Glu Trp Ser Asp Ser 
            340                 345                 350         


Ala Gln Gly Ser Glu Ser His Ser Leu 
        355                 360     


<210>  7
<211>  361
<212>  PRT
<213>  Homo sapiens

<400>  7

Met Arg Val Thr Ala Pro Arg Thr Val Leu Leu Leu Leu Ser Gly Ala 
1               5                   10                  15      


Leu Ala Leu Thr Glu Thr Trp Ala Gly Ser His Ser Leu Lys Tyr Phe 
            20                  25                  30          


His Thr Ser Val Ser Arg Pro Gly Arg Gly Glu Pro Arg Phe Ile Ser 
        35                  40                  45              


Val Gly Tyr Val Asp Asp Thr Gln Phe Val Arg Phe Asp Asn Asp Ala 
    50                  55                  60                  


Ala Ser Pro Arg Met Val Pro Arg Ala Pro Trp Met Glu Gln Glu Gly 
65                  70                  75                  80  


Ser Glu Tyr Trp Asp Arg Glu Thr Arg Ser Ala Arg Asp Thr Ala Gln 
                85                  90                  95      


Ile Phe Arg Val Asn Leu Arg Thr Leu Arg Gly Tyr Tyr Asn Gln Ser 
            100                 105                 110         


Glu Ala Gly Ser His Thr Leu Gln Trp Met His Gly Cys Glu Leu Gly 
        115                 120                 125             


Pro Asp Gly Arg Phe Leu Arg Gly Tyr Glu Gln Phe Ala Tyr Asp Gly 
    130                 135                 140                 


Lys Asp Tyr Leu Thr Leu Asn Glu Asp Leu Arg Ser Trp Thr Ala Val 
145                 150                 155                 160 


Asp Thr Ala Ala Gln Ile Ser Glu Gln Lys Ser Asn Asp Ala Ser Glu 
                165                 170                 175     


Ala Glu His Gln Arg Ala Tyr Leu Glu Asp Thr Cys Val Glu Trp Leu 
            180                 185                 190         


His Lys Tyr Leu Glu Lys Gly Lys Glu Thr Leu Leu His Leu Glu Pro 
        195                 200                 205             


Pro Lys Thr His Val Thr His His Pro Ile Ser Asp His Glu Ala Thr 
    210                 215                 220                 


Leu Arg Cys Trp Ala Leu Gly Phe Tyr Pro Ala Glu Ile Thr Leu Thr 
225                 230                 235                 240 


Trp Gln Gln Asp Gly Glu Gly His Thr Gln Asp Thr Glu Leu Val Glu 
                245                 250                 255     


Thr Arg Pro Ala Gly Asp Gly Thr Phe Gln Lys Trp Ala Ala Val Val 
            260                 265                 270         


Val Pro Ser Gly Glu Glu Gln Arg Tyr Thr Cys His Val Gln His Glu 
        275                 280                 285             


Gly Leu Pro Glu Pro Val Thr Leu Arg Trp Lys Pro Ala Ser Gln Pro 
    290                 295                 300                 


Thr Ile Pro Ile Val Gly Ile Ile Ala Gly Leu Val Leu Leu Gly Ser 
305                 310                 315                 320 


Val Val Ser Gly Ala Val Val Ala Ala Val Ile Trp Arg Lys Lys Ser 
                325                 330                 335     


Ser Gly Gly Lys Gly Gly Ser Tyr Ser Lys Ala Glu Trp Ser Asp Ser 
            340                 345                 350         


Ala Gln Gly Ser Glu Ser His Ser Leu 
        355                 360     


<210>  8
<211>  361
<212>  PRT
<213>  Homo sapiens

<400>  8

Met Arg Val Thr Ala Pro Arg Thr Val Leu Leu Leu Leu Ser Ala Ala 
1               5                   10                  15      


Leu Ala Leu Thr Glu Thr Trp Ala Gly Ser His Ser Leu Lys Tyr Phe 
            20                  25                  30          


His Thr Ser Val Ser Arg Pro Gly Arg Gly Glu Pro Arg Phe Ile Ser 
        35                  40                  45              


Val Gly Tyr Val Asp Asp Thr Gln Phe Val Arg Phe Asp Asn Asp Ala 
    50                  55                  60                  


Ala Ser Pro Arg Met Val Pro Arg Ala Pro Trp Met Glu Gln Glu Gly 
65                  70                  75                  80  


Ser Glu Tyr Trp Asp Arg Glu Thr Arg Ser Ala Arg Asp Thr Ala Gln 
                85                  90                  95      


Ile Phe Arg Val Asn Leu Arg Thr Leu Arg Gly Tyr Tyr Asn Gln Ser 
            100                 105                 110         


Glu Ala Gly Ser His Thr Leu Gln Trp Met His Gly Cys Glu Leu Gly 
        115                 120                 125             


Pro Asp Gly Arg Phe Leu Arg Gly Tyr Glu Gln Phe Ala Tyr Asp Gly 
    130                 135                 140                 


Lys Asp Tyr Leu Thr Leu Asn Glu Asp Leu Arg Ser Trp Thr Ala Val 
145                 150                 155                 160 


Asp Thr Ala Ala Gln Ile Ser Glu Gln Lys Ser Asn Asp Ala Ser Glu 
                165                 170                 175     


Ala Glu His Gln Arg Ala Tyr Leu Glu Asp Thr Cys Val Glu Trp Leu 
            180                 185                 190         


His Lys Tyr Leu Glu Lys Gly Lys Glu Thr Leu Leu His Leu Glu Pro 
        195                 200                 205             


Pro Lys Thr His Val Thr His His Pro Ile Ser Asp His Glu Ala Thr 
    210                 215                 220                 


Leu Arg Cys Trp Ala Leu Gly Phe Tyr Pro Ala Glu Ile Thr Leu Thr 
225                 230                 235                 240 


Trp Gln Gln Asp Gly Glu Gly His Thr Gln Asp Thr Glu Leu Val Glu 
                245                 250                 255     


Thr Arg Pro Ala Gly Asp Gly Thr Phe Gln Lys Trp Ala Ala Val Val 
            260                 265                 270         


Val Pro Ser Gly Glu Glu Gln Arg Tyr Thr Cys His Val Gln His Glu 
        275                 280                 285             


Gly Leu Pro Glu Pro Val Thr Leu Arg Trp Lys Pro Ala Ser Gln Pro 
    290                 295                 300                 


Thr Ile Pro Ile Val Gly Ile Ile Ala Gly Leu Val Leu Leu Gly Ser 
305                 310                 315                 320 


Val Val Ser Gly Ala Val Val Ala Ala Val Ile Trp Arg Lys Lys Ser 
                325                 330                 335     


Ser Gly Gly Lys Gly Gly Ser Tyr Ser Lys Ala Glu Trp Ser Asp Ser 
            340                 345                 350         


Ala Gln Gly Ser Glu Ser His Ser Leu 
        355                 360     


<210>  9
<211>  361
<212>  PRT
<213>  Homo sapiens

<400>  9

Met Arg Val Thr Ala Pro Arg Thr Leu Leu Leu Leu Leu Trp Gly Ala 
1               5                   10                  15      


Val Ala Leu Thr Glu Thr Trp Ala Gly Ser His Ser Leu Lys Tyr Phe 
            20                  25                  30          


His Thr Ser Val Ser Arg Pro Gly Arg Gly Glu Pro Arg Phe Ile Ser 
        35                  40                  45              


Val Gly Tyr Val Asp Asp Thr Gln Phe Val Arg Phe Asp Asn Asp Ala 
    50                  55                  60                  


Ala Ser Pro Arg Met Val Pro Arg Ala Pro Trp Met Glu Gln Glu Gly 
65                  70                  75                  80  


Ser Glu Tyr Trp Asp Arg Glu Thr Arg Ser Ala Arg Asp Thr Ala Gln 
                85                  90                  95      


Ile Phe Arg Val Asn Leu Arg Thr Leu Arg Gly Tyr Tyr Asn Gln Ser 
            100                 105                 110         


Glu Ala Gly Ser His Thr Leu Gln Trp Met His Gly Cys Glu Leu Gly 
        115                 120                 125             


Pro Asp Gly Arg Phe Leu Arg Gly Tyr Glu Gln Phe Ala Tyr Asp Gly 
    130                 135                 140                 


Lys Asp Tyr Leu Thr Leu Asn Glu Asp Leu Arg Ser Trp Thr Ala Val 
145                 150                 155                 160 


Asp Thr Ala Ala Gln Ile Ser Glu Gln Lys Ser Asn Asp Ala Ser Glu 
                165                 170                 175     


Ala Glu His Gln Arg Ala Tyr Leu Glu Asp Thr Cys Val Glu Trp Leu 
            180                 185                 190         


His Lys Tyr Leu Glu Lys Gly Lys Glu Thr Leu Leu His Leu Glu Pro 
        195                 200                 205             


Pro Lys Thr His Val Thr His His Pro Ile Ser Asp His Glu Ala Thr 
    210                 215                 220                 


Leu Arg Cys Trp Ala Leu Gly Phe Tyr Pro Ala Glu Ile Thr Leu Thr 
225                 230                 235                 240 


Trp Gln Gln Asp Gly Glu Gly His Thr Gln Asp Thr Glu Leu Val Glu 
                245                 250                 255     


Thr Arg Pro Ala Gly Asp Gly Thr Phe Gln Lys Trp Ala Ala Val Val 
            260                 265                 270         


Val Pro Ser Gly Glu Glu Gln Arg Tyr Thr Cys His Val Gln His Glu 
        275                 280                 285             


Gly Leu Pro Glu Pro Val Thr Leu Arg Trp Lys Pro Ala Ser Gln Pro 
    290                 295                 300                 


Thr Ile Pro Ile Val Gly Ile Ile Ala Gly Leu Val Leu Leu Gly Ser 
305                 310                 315                 320 


Val Val Ser Gly Ala Val Val Ala Ala Val Ile Trp Arg Lys Lys Ser 
                325                 330                 335     


Ser Gly Gly Lys Gly Gly Ser Tyr Ser Lys Ala Glu Trp Ser Asp Ser 
            340                 345                 350         


Ala Gln Gly Ser Glu Ser His Ser Leu 
        355                 360     


<210>  10
<211>  361
<212>  PRT
<213>  Homo sapiens

<400>  10

Met Arg Val Thr Ala Pro Arg Thr Leu Leu Leu Leu Leu Trp Gly Ala 
1               5                   10                  15      


Leu Ala Leu Thr Glu Thr Trp Ala Gly Ser His Ser Leu Lys Tyr Phe 
            20                  25                  30          


His Thr Ser Val Ser Arg Pro Gly Arg Gly Glu Pro Arg Phe Ile Ser 
        35                  40                  45              


Val Gly Tyr Val Asp Asp Thr Gln Phe Val Arg Phe Asp Asn Asp Ala 
    50                  55                  60                  


Ala Ser Pro Arg Met Val Pro Arg Ala Pro Trp Met Glu Gln Glu Gly 
65                  70                  75                  80  


Ser Glu Tyr Trp Asp Arg Glu Thr Arg Ser Ala Arg Asp Thr Ala Gln 
                85                  90                  95      


Ile Phe Arg Val Asn Leu Arg Thr Leu Arg Gly Tyr Tyr Asn Gln Ser 
            100                 105                 110         


Glu Ala Gly Ser His Thr Leu Gln Trp Met His Gly Cys Glu Leu Gly 
        115                 120                 125             


Pro Asp Gly Arg Phe Leu Arg Gly Tyr Glu Gln Phe Ala Tyr Asp Gly 
    130                 135                 140                 


Lys Asp Tyr Leu Thr Leu Asn Glu Asp Leu Arg Ser Trp Thr Ala Val 
145                 150                 155                 160 


Asp Thr Ala Ala Gln Ile Ser Glu Gln Lys Ser Asn Asp Ala Ser Glu 
                165                 170                 175     


Ala Glu His Gln Arg Ala Tyr Leu Glu Asp Thr Cys Val Glu Trp Leu 
            180                 185                 190         


His Lys Tyr Leu Glu Lys Gly Lys Glu Thr Leu Leu His Leu Glu Pro 
        195                 200                 205             


Pro Lys Thr His Val Thr His His Pro Ile Ser Asp His Glu Ala Thr 
    210                 215                 220                 


Leu Arg Cys Trp Ala Leu Gly Phe Tyr Pro Ala Glu Ile Thr Leu Thr 
225                 230                 235                 240 


Trp Gln Gln Asp Gly Glu Gly His Thr Gln Asp Thr Glu Leu Val Glu 
                245                 250                 255     


Thr Arg Pro Ala Gly Asp Gly Thr Phe Gln Lys Trp Ala Ala Val Val 
            260                 265                 270         


Val Pro Ser Gly Glu Glu Gln Arg Tyr Thr Cys His Val Gln His Glu 
        275                 280                 285             


Gly Leu Pro Glu Pro Val Thr Leu Arg Trp Lys Pro Ala Ser Gln Pro 
    290                 295                 300                 


Thr Ile Pro Ile Val Gly Ile Ile Ala Gly Leu Val Leu Leu Gly Ser 
305                 310                 315                 320 


Val Val Ser Gly Ala Val Val Ala Ala Val Ile Trp Arg Lys Lys Ser 
                325                 330                 335     


Ser Gly Gly Lys Gly Gly Ser Tyr Ser Lys Ala Glu Trp Ser Asp Ser 
            340                 345                 350         


Ala Gln Gly Ser Glu Ser His Ser Leu 
        355                 360     


<210>  11
<211>  361
<212>  PRT
<213>  Homo sapiens

<400>  11

Met Arg Val Thr Ala Pro Arg Thr Val Leu Leu Leu Leu Trp Gly Ala 
1               5                   10                  15      


Val Ala Leu Thr Glu Thr Trp Ala Gly Ser His Ser Leu Lys Tyr Phe 
            20                  25                  30          


His Thr Ser Val Ser Arg Pro Gly Arg Gly Glu Pro Arg Phe Ile Ser 
        35                  40                  45              


Val Gly Tyr Val Asp Asp Thr Gln Phe Val Arg Phe Asp Asn Asp Ala 
    50                  55                  60                  


Ala Ser Pro Arg Met Val Pro Arg Ala Pro Trp Met Glu Gln Glu Gly 
65                  70                  75                  80  


Ser Glu Tyr Trp Asp Arg Glu Thr Arg Ser Ala Arg Asp Thr Ala Gln 
                85                  90                  95      


Ile Phe Arg Val Asn Leu Arg Thr Leu Arg Gly Tyr Tyr Asn Gln Ser 
            100                 105                 110         


Glu Ala Gly Ser His Thr Leu Gln Trp Met His Gly Cys Glu Leu Gly 
        115                 120                 125             


Pro Asp Gly Arg Phe Leu Arg Gly Tyr Glu Gln Phe Ala Tyr Asp Gly 
    130                 135                 140                 


Lys Asp Tyr Leu Thr Leu Asn Glu Asp Leu Arg Ser Trp Thr Ala Val 
145                 150                 155                 160 


Asp Thr Ala Ala Gln Ile Ser Glu Gln Lys Ser Asn Asp Ala Ser Glu 
                165                 170                 175     


Ala Glu His Gln Arg Ala Tyr Leu Glu Asp Thr Cys Val Glu Trp Leu 
            180                 185                 190         


His Lys Tyr Leu Glu Lys Gly Lys Glu Thr Leu Leu His Leu Glu Pro 
        195                 200                 205             


Pro Lys Thr His Val Thr His His Pro Ile Ser Asp His Glu Ala Thr 
    210                 215                 220                 


Leu Arg Cys Trp Ala Leu Gly Phe Tyr Pro Ala Glu Ile Thr Leu Thr 
225                 230                 235                 240 


Trp Gln Gln Asp Gly Glu Gly His Thr Gln Asp Thr Glu Leu Val Glu 
                245                 250                 255     


Thr Arg Pro Ala Gly Asp Gly Thr Phe Gln Lys Trp Ala Ala Val Val 
            260                 265                 270         


Val Pro Ser Gly Glu Glu Gln Arg Tyr Thr Cys His Val Gln His Glu 
        275                 280                 285             


Gly Leu Pro Glu Pro Val Thr Leu Arg Trp Lys Pro Ala Ser Gln Pro 
    290                 295                 300                 


Thr Ile Pro Ile Val Gly Ile Ile Ala Gly Leu Val Leu Leu Gly Ser 
305                 310                 315                 320 


Val Val Ser Gly Ala Val Val Ala Ala Val Ile Trp Arg Lys Lys Ser 
                325                 330                 335     


Ser Gly Gly Lys Gly Gly Ser Tyr Ser Lys Ala Glu Trp Ser Asp Ser 
            340                 345                 350         


Ala Gln Gly Ser Glu Ser His Ser Leu 
        355                 360     


<210>  12
<211>  361
<212>  PRT
<213>  Homo sapiens

<400>  12

Met Arg Val Met Ala Pro Arg Thr Leu Ile Leu Leu Leu Ser Gly Ala 
1               5                   10                  15      


Leu Ala Leu Thr Glu Thr Trp Ala Gly Ser His Ser Leu Lys Tyr Phe 
            20                  25                  30          


His Thr Ser Val Ser Arg Pro Gly Arg Gly Glu Pro Arg Phe Ile Ser 
        35                  40                  45              


Val Gly Tyr Val Asp Asp Thr Gln Phe Val Arg Phe Asp Asn Asp Ala 
    50                  55                  60                  


Ala Ser Pro Arg Met Val Pro Arg Ala Pro Trp Met Glu Gln Glu Gly 
65                  70                  75                  80  


Ser Glu Tyr Trp Asp Arg Glu Thr Arg Ser Ala Arg Asp Thr Ala Gln 
                85                  90                  95      


Ile Phe Arg Val Asn Leu Arg Thr Leu Arg Gly Tyr Tyr Asn Gln Ser 
            100                 105                 110         


Glu Ala Gly Ser His Thr Leu Gln Trp Met His Gly Cys Glu Leu Gly 
        115                 120                 125             


Pro Asp Gly Arg Phe Leu Arg Gly Tyr Glu Gln Phe Ala Tyr Asp Gly 
    130                 135                 140                 


Lys Asp Tyr Leu Thr Leu Asn Glu Asp Leu Arg Ser Trp Thr Ala Val 
145                 150                 155                 160 


Asp Thr Ala Ala Gln Ile Ser Glu Gln Lys Ser Asn Asp Ala Ser Glu 
                165                 170                 175     


Ala Glu His Gln Arg Ala Tyr Leu Glu Asp Thr Cys Val Glu Trp Leu 
            180                 185                 190         


His Lys Tyr Leu Glu Lys Gly Lys Glu Thr Leu Leu His Leu Glu Pro 
        195                 200                 205             


Pro Lys Thr His Val Thr His His Pro Ile Ser Asp His Glu Ala Thr 
    210                 215                 220                 


Leu Arg Cys Trp Ala Leu Gly Phe Tyr Pro Ala Glu Ile Thr Leu Thr 
225                 230                 235                 240 


Trp Gln Gln Asp Gly Glu Gly His Thr Gln Asp Thr Glu Leu Val Glu 
                245                 250                 255     


Thr Arg Pro Ala Gly Asp Gly Thr Phe Gln Lys Trp Ala Ala Val Val 
            260                 265                 270         


Val Pro Ser Gly Glu Glu Gln Arg Tyr Thr Cys His Val Gln His Glu 
        275                 280                 285             


Gly Leu Pro Glu Pro Val Thr Leu Arg Trp Lys Pro Ala Ser Gln Pro 
    290                 295                 300                 


Thr Ile Pro Ile Val Gly Ile Ile Ala Gly Leu Val Leu Leu Gly Ser 
305                 310                 315                 320 


Val Val Ser Gly Ala Val Val Ala Ala Val Ile Trp Arg Lys Lys Ser 
                325                 330                 335     


Ser Gly Gly Lys Gly Gly Ser Tyr Ser Lys Ala Glu Trp Ser Asp Ser 
            340                 345                 350         


Ala Gln Gly Ser Glu Ser His Ser Leu 
        355                 360     


<210>  13
<211>  361
<212>  PRT
<213>  Homo sapiens

<400>  13

Met Arg Val Met Ala Pro Arg Ala Leu Leu Leu Leu Leu Ser Gly Gly 
1               5                   10                  15      


Leu Ala Leu Thr Glu Thr Trp Ala Gly Ser His Ser Leu Lys Tyr Phe 
            20                  25                  30          


His Thr Ser Val Ser Arg Pro Gly Arg Gly Glu Pro Arg Phe Ile Ser 
        35                  40                  45              


Val Gly Tyr Val Asp Asp Thr Gln Phe Val Arg Phe Asp Asn Asp Ala 
    50                  55                  60                  


Ala Ser Pro Arg Met Val Pro Arg Ala Pro Trp Met Glu Gln Glu Gly 
65                  70                  75                  80  


Ser Glu Tyr Trp Asp Arg Glu Thr Arg Ser Ala Arg Asp Thr Ala Gln 
                85                  90                  95      


Ile Phe Arg Val Asn Leu Arg Thr Leu Arg Gly Tyr Tyr Asn Gln Ser 
            100                 105                 110         


Glu Ala Gly Ser His Thr Leu Gln Trp Met His Gly Cys Glu Leu Gly 
        115                 120                 125             


Pro Asp Gly Arg Phe Leu Arg Gly Tyr Glu Gln Phe Ala Tyr Asp Gly 
    130                 135                 140                 


Lys Asp Tyr Leu Thr Leu Asn Glu Asp Leu Arg Ser Trp Thr Ala Val 
145                 150                 155                 160 


Asp Thr Ala Ala Gln Ile Ser Glu Gln Lys Ser Asn Asp Ala Ser Glu 
                165                 170                 175     


Ala Glu His Gln Arg Ala Tyr Leu Glu Asp Thr Cys Val Glu Trp Leu 
            180                 185                 190         


His Lys Tyr Leu Glu Lys Gly Lys Glu Thr Leu Leu His Leu Glu Pro 
        195                 200                 205             


Pro Lys Thr His Val Thr His His Pro Ile Ser Asp His Glu Ala Thr 
    210                 215                 220                 


Leu Arg Cys Trp Ala Leu Gly Phe Tyr Pro Ala Glu Ile Thr Leu Thr 
225                 230                 235                 240 


Trp Gln Gln Asp Gly Glu Gly His Thr Gln Asp Thr Glu Leu Val Glu 
                245                 250                 255     


Thr Arg Pro Ala Gly Asp Gly Thr Phe Gln Lys Trp Ala Ala Val Val 
            260                 265                 270         


Val Pro Ser Gly Glu Glu Gln Arg Tyr Thr Cys His Val Gln His Glu 
        275                 280                 285             


Gly Leu Pro Glu Pro Val Thr Leu Arg Trp Lys Pro Ala Ser Gln Pro 
    290                 295                 300                 


Thr Ile Pro Ile Val Gly Ile Ile Ala Gly Leu Val Leu Leu Gly Ser 
305                 310                 315                 320 


Val Val Ser Gly Ala Val Val Ala Ala Val Ile Trp Arg Lys Lys Ser 
                325                 330                 335     


Ser Gly Gly Lys Gly Gly Ser Tyr Ser Lys Ala Glu Trp Ser Asp Ser 
            340                 345                 350         


Ala Gln Gly Ser Glu Ser His Ser Leu 
        355                 360     


<210>  14
<211>  361
<212>  PRT
<213>  Homo sapiens

<400>  14

Met Arg Val Met Ala Pro Arg Thr Leu Leu Leu Leu Leu Ser Gly Ala 
1               5                   10                  15      


Leu Ala Leu Thr Glu Thr Trp Ala Gly Ser His Ser Leu Lys Tyr Phe 
            20                  25                  30          


His Thr Ser Val Ser Arg Pro Gly Arg Gly Glu Pro Arg Phe Ile Ser 
        35                  40                  45              


Val Gly Tyr Val Asp Asp Thr Gln Phe Val Arg Phe Asp Asn Asp Ala 
    50                  55                  60                  


Ala Ser Pro Arg Met Val Pro Arg Ala Pro Trp Met Glu Gln Glu Gly 
65                  70                  75                  80  


Ser Glu Tyr Trp Asp Arg Glu Thr Arg Ser Ala Arg Asp Thr Ala Gln 
                85                  90                  95      


Ile Phe Arg Val Asn Leu Arg Thr Leu Arg Gly Tyr Tyr Asn Gln Ser 
            100                 105                 110         


Glu Ala Gly Ser His Thr Leu Gln Trp Met His Gly Cys Glu Leu Gly 
        115                 120                 125             


Pro Asp Gly Arg Phe Leu Arg Gly Tyr Glu Gln Phe Ala Tyr Asp Gly 
    130                 135                 140                 


Lys Asp Tyr Leu Thr Leu Asn Glu Asp Leu Arg Ser Trp Thr Ala Val 
145                 150                 155                 160 


Asp Thr Ala Ala Gln Ile Ser Glu Gln Lys Ser Asn Asp Ala Ser Glu 
                165                 170                 175     


Ala Glu His Gln Arg Ala Tyr Leu Glu Asp Thr Cys Val Glu Trp Leu 
            180                 185                 190         


His Lys Tyr Leu Glu Lys Gly Lys Glu Thr Leu Leu His Leu Glu Pro 
        195                 200                 205             


Pro Lys Thr His Val Thr His His Pro Ile Ser Asp His Glu Ala Thr 
    210                 215                 220                 


Leu Arg Cys Trp Ala Leu Gly Phe Tyr Pro Ala Glu Ile Thr Leu Thr 
225                 230                 235                 240 


Trp Gln Gln Asp Gly Glu Gly His Thr Gln Asp Thr Glu Leu Val Glu 
                245                 250                 255     


Thr Arg Pro Ala Gly Asp Gly Thr Phe Gln Lys Trp Ala Ala Val Val 
            260                 265                 270         


Val Pro Ser Gly Glu Glu Gln Arg Tyr Thr Cys His Val Gln His Glu 
        275                 280                 285             


Gly Leu Pro Glu Pro Val Thr Leu Arg Trp Lys Pro Ala Ser Gln Pro 
    290                 295                 300                 


Thr Ile Pro Ile Val Gly Ile Ile Ala Gly Leu Val Leu Leu Gly Ser 
305                 310                 315                 320 


Val Val Ser Gly Ala Val Val Ala Ala Val Ile Trp Arg Lys Lys Ser 
                325                 330                 335     


Ser Gly Gly Lys Gly Gly Ser Tyr Ser Lys Ala Glu Trp Ser Asp Ser 
            340                 345                 350         


Ala Gln Gly Ser Glu Ser His Ser Leu 
        355                 360     


<210>  15
<211>  361
<212>  PRT
<213>  Homo sapiens

<400>  15

Met Arg Val Met Ala Pro Gln Ala Leu Leu Leu Leu Leu Ser Gly Ala 
1               5                   10                  15      


Leu Ala Leu Ile Glu Thr Trp Ala Gly Ser His Ser Leu Lys Tyr Phe 
            20                  25                  30          


His Thr Ser Val Ser Arg Pro Gly Arg Gly Glu Pro Arg Phe Ile Ser 
        35                  40                  45              


Val Gly Tyr Val Asp Asp Thr Gln Phe Val Arg Phe Asp Asn Asp Ala 
    50                  55                  60                  


Ala Ser Pro Arg Met Val Pro Arg Ala Pro Trp Met Glu Gln Glu Gly 
65                  70                  75                  80  


Ser Glu Tyr Trp Asp Arg Glu Thr Arg Ser Ala Arg Asp Thr Ala Gln 
                85                  90                  95      


Ile Phe Arg Val Asn Leu Arg Thr Leu Arg Gly Tyr Tyr Asn Gln Ser 
            100                 105                 110         


Glu Ala Gly Ser His Thr Leu Gln Trp Met His Gly Cys Glu Leu Gly 
        115                 120                 125             


Pro Asp Gly Arg Phe Leu Arg Gly Tyr Glu Gln Phe Ala Tyr Asp Gly 
    130                 135                 140                 


Lys Asp Tyr Leu Thr Leu Asn Glu Asp Leu Arg Ser Trp Thr Ala Val 
145                 150                 155                 160 


Asp Thr Ala Ala Gln Ile Ser Glu Gln Lys Ser Asn Asp Ala Ser Glu 
                165                 170                 175     


Ala Glu His Gln Arg Ala Tyr Leu Glu Asp Thr Cys Val Glu Trp Leu 
            180                 185                 190         


His Lys Tyr Leu Glu Lys Gly Lys Glu Thr Leu Leu His Leu Glu Pro 
        195                 200                 205             


Pro Lys Thr His Val Thr His His Pro Ile Ser Asp His Glu Ala Thr 
    210                 215                 220                 


Leu Arg Cys Trp Ala Leu Gly Phe Tyr Pro Ala Glu Ile Thr Leu Thr 
225                 230                 235                 240 


Trp Gln Gln Asp Gly Glu Gly His Thr Gln Asp Thr Glu Leu Val Glu 
                245                 250                 255     


Thr Arg Pro Ala Gly Asp Gly Thr Phe Gln Lys Trp Ala Ala Val Val 
            260                 265                 270         


Val Pro Ser Gly Glu Glu Gln Arg Tyr Thr Cys His Val Gln His Glu 
        275                 280                 285             


Gly Leu Pro Glu Pro Val Thr Leu Arg Trp Lys Pro Ala Ser Gln Pro 
    290                 295                 300                 


Thr Ile Pro Ile Val Gly Ile Ile Ala Gly Leu Val Leu Leu Gly Ser 
305                 310                 315                 320 


Val Val Ser Gly Ala Val Val Ala Ala Val Ile Trp Arg Lys Lys Ser 
                325                 330                 335     


Ser Gly Gly Lys Gly Gly Ser Tyr Ser Lys Ala Glu Trp Ser Asp Ser 
            340                 345                 350         


Ala Gln Gly Ser Glu Ser His Ser Leu 
        355                 360     


<210>  16
<211>  361
<212>  PRT
<213>  Homo sapiens

<400>  16

Met Val Val Met Ala Pro Arg Thr Leu Phe Leu Leu Leu Ser Gly Ala 
1               5                   10                  15      


Leu Thr Leu Thr Glu Thr Trp Ala Gly Ser His Ser Leu Lys Tyr Phe 
            20                  25                  30          


His Thr Ser Val Ser Arg Pro Gly Arg Gly Glu Pro Arg Phe Ile Ser 
        35                  40                  45              


Val Gly Tyr Val Asp Asp Thr Gln Phe Val Arg Phe Asp Asn Asp Ala 
    50                  55                  60                  


Ala Ser Pro Arg Met Val Pro Arg Ala Pro Trp Met Glu Gln Glu Gly 
65                  70                  75                  80  


Ser Glu Tyr Trp Asp Arg Glu Thr Arg Ser Ala Arg Asp Thr Ala Gln 
                85                  90                  95      


Ile Phe Arg Val Asn Leu Arg Thr Leu Arg Gly Tyr Tyr Asn Gln Ser 
            100                 105                 110         


Glu Ala Gly Ser His Thr Leu Gln Trp Met His Gly Cys Glu Leu Gly 
        115                 120                 125             


Pro Asp Arg Arg Phe Leu Arg Gly Tyr Glu Gln Phe Ala Tyr Asp Gly 
    130                 135                 140                 


Lys Asp Tyr Leu Thr Leu Asn Glu Asp Leu Arg Ser Trp Thr Ala Val 
145                 150                 155                 160 


Asp Thr Ala Ala Gln Ile Ser Glu Gln Lys Ser Asn Asp Ala Ser Glu 
                165                 170                 175     


Ala Glu His Gln Arg Ala Tyr Leu Glu Asp Thr Cys Val Glu Trp Leu 
            180                 185                 190         


His Lys Tyr Leu Glu Lys Gly Lys Glu Thr Leu Leu His Leu Glu Pro 
        195                 200                 205             


Pro Lys Thr His Val Thr His His Pro Ile Ser Asp His Glu Ala Thr 
    210                 215                 220                 


Leu Arg Cys Trp Ala Leu Gly Phe Tyr Pro Ala Glu Ile Thr Leu Thr 
225                 230                 235                 240 


Trp Gln Gln Asp Gly Glu Gly His Thr Gln Asp Thr Glu Leu Val Glu 
                245                 250                 255     


Thr Arg Pro Ala Gly Asp Gly Thr Phe Gln Lys Trp Ala Ala Val Val 
            260                 265                 270         


Val Pro Ser Gly Glu Glu Gln Arg Tyr Thr Cys His Val Gln His Glu 
        275                 280                 285             


Gly Leu Pro Glu Pro Val Thr Leu Arg Trp Lys Pro Ala Ser Gln Pro 
    290                 295                 300                 


Thr Ile Pro Ile Val Gly Ile Ile Ala Gly Leu Val Leu Leu Gly Ser 
305                 310                 315                 320 


Val Val Ser Gly Ala Val Val Ala Ala Val Ile Trp Arg Lys Lys Ser 
                325                 330                 335     


Ser Gly Gly Lys Gly Gly Ser Tyr Ser Lys Ala Glu Trp Ser Asp Ser 
            340                 345                 350         


Ala Gln Gly Ser Glu Ser His Ser Leu 
        355                 360     


<210>  17
<211>  361
<212>  PRT
<213>  Homo sapiens

<400>  17

Met Ala Val Met Ala Pro Arg Thr Leu Leu Leu Leu Leu Ser Gly Ala 
1               5                   10                  15      


Leu Ala Leu Thr Gln Thr Trp Ala Gly Ser His Ser Leu Lys Tyr Phe 
            20                  25                  30          


His Thr Ser Val Ser Arg Pro Gly Arg Gly Glu Pro Arg Phe Ile Ser 
        35                  40                  45              


Val Gly Tyr Val Asp Asp Thr Gln Phe Val Arg Phe Asp Asn Asp Ala 
    50                  55                  60                  


Ala Ser Pro Arg Met Val Pro Arg Ala Pro Trp Met Glu Gln Glu Gly 
65                  70                  75                  80  


Ser Glu Tyr Trp Asp Arg Glu Thr Arg Ser Ala Arg Asp Thr Ala Gln 
                85                  90                  95      


Ile Phe Arg Val Asn Leu Arg Thr Leu Arg Gly Tyr Tyr Asn Gln Ser 
            100                 105                 110         


Glu Ala Gly Ser His Thr Leu Gln Trp Met His Gly Cys Glu Leu Gly 
        115                 120                 125             


Pro Asp Arg Arg Phe Leu Arg Gly Tyr Glu Gln Phe Ala Tyr Asp Gly 
    130                 135                 140                 


Lys Asp Tyr Leu Thr Leu Asn Glu Asp Leu Arg Ser Trp Thr Ala Val 
145                 150                 155                 160 


Asp Thr Ala Ala Gln Ile Ser Glu Gln Lys Ser Asn Asp Ala Ser Glu 
                165                 170                 175     


Ala Glu His Gln Arg Ala Tyr Leu Glu Asp Thr Cys Val Glu Trp Leu 
            180                 185                 190         


His Lys Tyr Leu Glu Lys Gly Lys Glu Thr Leu Leu His Leu Glu Pro 
        195                 200                 205             


Pro Lys Thr His Val Thr His His Pro Ile Ser Asp His Glu Ala Thr 
    210                 215                 220                 


Leu Arg Cys Trp Ala Leu Gly Phe Tyr Pro Ala Glu Ile Thr Leu Thr 
225                 230                 235                 240 


Trp Gln Gln Asp Gly Glu Gly His Thr Gln Asp Thr Glu Leu Val Glu 
                245                 250                 255     


Thr Arg Pro Ala Gly Asp Gly Thr Phe Gln Lys Trp Ala Ala Val Val 
            260                 265                 270         


Val Pro Ser Gly Glu Glu Gln Arg Tyr Thr Cys His Val Gln His Glu 
        275                 280                 285             


Gly Leu Pro Glu Pro Val Thr Leu Arg Trp Lys Pro Ala Ser Gln Pro 
    290                 295                 300                 


Thr Ile Pro Ile Val Gly Ile Ile Ala Gly Leu Val Leu Leu Gly Ser 
305                 310                 315                 320 


Val Val Ser Gly Ala Val Val Ala Ala Val Ile Trp Arg Lys Lys Ser 
                325                 330                 335     


Ser Gly Gly Lys Gly Gly Ser Tyr Ser Lys Ala Glu Trp Ser Asp Ser 
            340                 345                 350         


Ala Gln Gly Ser Glu Ser His Ser Leu 
        355                 360     


<210>  18
<211>  361
<212>  PRT
<213>  Homo sapiens

<400>  18

Met Ala Val Met Ala Pro Arg Thr Leu Val Leu Leu Leu Ser Gly Ala 
1               5                   10                  15      


Leu Ala Leu Thr Gln Thr Trp Ala Gly Ser His Ser Leu Lys Tyr Phe 
            20                  25                  30          


His Thr Ser Val Ser Arg Pro Gly Arg Gly Glu Pro Arg Phe Ile Ser 
        35                  40                  45              


Val Gly Tyr Val Asp Asp Thr Gln Phe Val Arg Phe Asp Asn Asp Ala 
    50                  55                  60                  


Ala Ser Pro Arg Met Val Pro Arg Ala Pro Trp Met Glu Gln Glu Gly 
65                  70                  75                  80  


Ser Glu Tyr Trp Asp Arg Glu Thr Arg Ser Ala Arg Asp Thr Ala Gln 
                85                  90                  95      


Ile Phe Arg Val Asn Leu Arg Thr Leu Arg Gly Tyr Tyr Asn Gln Ser 
            100                 105                 110         


Glu Ala Gly Ser His Thr Leu Gln Trp Met His Gly Cys Glu Leu Gly 
        115                 120                 125             


Pro Asp Arg Arg Phe Leu Arg Gly Tyr Glu Gln Phe Ala Tyr Asp Gly 
    130                 135                 140                 


Lys Asp Tyr Leu Thr Leu Asn Glu Asp Leu Arg Ser Trp Thr Ala Val 
145                 150                 155                 160 


Asp Thr Ala Ala Gln Ile Ser Glu Gln Lys Ser Asn Asp Ala Ser Glu 
                165                 170                 175     


Ala Glu His Gln Arg Ala Tyr Leu Glu Asp Thr Cys Val Glu Trp Leu 
            180                 185                 190         


His Lys Tyr Leu Glu Lys Gly Lys Glu Thr Leu Leu His Leu Glu Pro 
        195                 200                 205             


Pro Lys Thr His Val Thr His His Pro Ile Ser Asp His Glu Ala Thr 
    210                 215                 220                 


Leu Arg Cys Trp Ala Leu Gly Phe Tyr Pro Ala Glu Ile Thr Leu Thr 
225                 230                 235                 240 


Trp Gln Gln Asp Gly Glu Gly His Thr Gln Asp Thr Glu Leu Val Glu 
                245                 250                 255     


Thr Arg Pro Ala Gly Asp Gly Thr Phe Gln Lys Trp Ala Ala Val Val 
            260                 265                 270         


Val Pro Ser Gly Glu Glu Gln Arg Tyr Thr Cys His Val Gln His Glu 
        275                 280                 285             


Gly Leu Pro Glu Pro Val Thr Leu Arg Trp Lys Pro Ala Ser Gln Pro 
    290                 295                 300                 


Thr Ile Pro Ile Val Gly Ile Ile Ala Gly Leu Val Leu Leu Gly Ser 
305                 310                 315                 320 


Val Val Ser Gly Ala Val Val Ala Ala Val Ile Trp Arg Lys Lys Ser 
                325                 330                 335     


Ser Gly Gly Lys Gly Gly Ser Tyr Ser Lys Ala Glu Trp Ser Asp Ser 
            340                 345                 350         


Ala Gln Gly Ser Glu Ser His Ser Leu 
        355                 360     


<210>  19
<211>  361
<212>  PRT
<213>  Homo sapiens

<400>  19

Met Ala Val Met Ala Pro Arg Thr Leu Leu Leu Leu Leu Leu Gly Ala 
1               5                   10                  15      


Leu Ala Leu Thr Gln Thr Trp Ala Gly Ser His Ser Leu Lys Tyr Phe 
            20                  25                  30          


His Thr Ser Val Ser Arg Pro Gly Arg Gly Glu Pro Arg Phe Ile Ser 
        35                  40                  45              


Val Gly Tyr Val Asp Asp Thr Gln Phe Val Arg Phe Asp Asn Asp Ala 
    50                  55                  60                  


Ala Ser Pro Arg Met Val Pro Arg Ala Pro Trp Met Glu Gln Glu Gly 
65                  70                  75                  80  


Ser Glu Tyr Trp Asp Arg Glu Thr Arg Ser Ala Arg Asp Thr Ala Gln 
                85                  90                  95      


Ile Phe Arg Val Asn Leu Arg Thr Leu Arg Gly Tyr Tyr Asn Gln Ser 
            100                 105                 110         


Glu Ala Gly Ser His Thr Leu Gln Trp Met His Gly Cys Glu Leu Gly 
        115                 120                 125             


Pro Asp Arg Arg Phe Leu Arg Gly Tyr Glu Gln Phe Ala Tyr Asp Gly 
    130                 135                 140                 


Lys Asp Tyr Leu Thr Leu Asn Glu Asp Leu Arg Ser Trp Thr Ala Val 
145                 150                 155                 160 


Asp Thr Ala Ala Gln Ile Ser Glu Gln Lys Ser Asn Asp Ala Ser Glu 
                165                 170                 175     


Ala Glu His Gln Arg Ala Tyr Leu Glu Asp Thr Cys Val Glu Trp Leu 
            180                 185                 190         


His Lys Tyr Leu Glu Lys Gly Lys Glu Thr Leu Leu His Leu Glu Pro 
        195                 200                 205             


Pro Lys Thr His Val Thr His His Pro Ile Ser Asp His Glu Ala Thr 
    210                 215                 220                 


Leu Arg Cys Trp Ala Leu Gly Phe Tyr Pro Ala Glu Ile Thr Leu Thr 
225                 230                 235                 240 


Trp Gln Gln Asp Gly Glu Gly His Thr Gln Asp Thr Glu Leu Val Glu 
                245                 250                 255     


Thr Arg Pro Ala Gly Asp Gly Thr Phe Gln Lys Trp Ala Ala Val Val 
            260                 265                 270         


Val Pro Ser Gly Glu Glu Gln Arg Tyr Thr Cys His Val Gln His Glu 
        275                 280                 285             


Gly Leu Pro Glu Pro Val Thr Leu Arg Trp Lys Pro Ala Ser Gln Pro 
    290                 295                 300                 


Thr Ile Pro Ile Val Gly Ile Ile Ala Gly Leu Val Leu Leu Gly Ser 
305                 310                 315                 320 


Val Val Ser Gly Ala Val Val Ala Ala Val Ile Trp Arg Lys Lys Ser 
                325                 330                 335     


Ser Gly Gly Lys Gly Gly Ser Tyr Ser Lys Ala Glu Trp Ser Asp Ser 
            340                 345                 350         


Ala Gln Gly Ser Glu Ser His Ser Leu 
        355                 360     


<210>  20
<211>  361
<212>  PRT
<213>  Homo sapiens

<400>  20

Met Ala Ile Met Ala Pro Arg Thr Leu Val Leu Leu Leu Ser Gly Ala 
1               5                   10                  15      


Leu Ala Leu Thr Gln Thr Trp Ala Gly Ser His Ser Leu Lys Tyr Phe 
            20                  25                  30          


His Thr Ser Val Ser Arg Pro Gly Arg Gly Glu Pro Arg Phe Ile Ser 
        35                  40                  45              


Val Gly Tyr Val Asp Asp Thr Gln Phe Val Arg Phe Asp Asn Asp Ala 
    50                  55                  60                  


Ala Ser Pro Arg Met Val Pro Arg Ala Pro Trp Met Glu Gln Glu Gly 
65                  70                  75                  80  


Ser Glu Tyr Trp Asp Arg Glu Thr Arg Ser Ala Arg Asp Thr Ala Gln 
                85                  90                  95      


Ile Phe Arg Val Asn Leu Arg Thr Leu Arg Gly Tyr Tyr Asn Gln Ser 
            100                 105                 110         


Glu Ala Gly Ser His Thr Leu Gln Trp Met His Gly Cys Glu Leu Gly 
        115                 120                 125             


Pro Asp Arg Arg Phe Leu Arg Gly Tyr Glu Gln Phe Ala Tyr Asp Gly 
    130                 135                 140                 


Lys Asp Tyr Leu Thr Leu Asn Glu Asp Leu Arg Ser Trp Thr Ala Val 
145                 150                 155                 160 


Asp Thr Ala Ala Gln Ile Ser Glu Gln Lys Ser Asn Asp Ala Ser Glu 
                165                 170                 175     


Ala Glu His Gln Arg Ala Tyr Leu Glu Asp Thr Cys Val Glu Trp Leu 
            180                 185                 190         


His Lys Tyr Leu Glu Lys Gly Lys Glu Thr Leu Leu His Leu Glu Pro 
        195                 200                 205             


Pro Lys Thr His Val Thr His His Pro Ile Ser Asp His Glu Ala Thr 
    210                 215                 220                 


Leu Arg Cys Trp Ala Leu Gly Phe Tyr Pro Ala Glu Ile Thr Leu Thr 
225                 230                 235                 240 


Trp Gln Gln Asp Gly Glu Gly His Thr Gln Asp Thr Glu Leu Val Glu 
                245                 250                 255     


Thr Arg Pro Ala Gly Asp Gly Thr Phe Gln Lys Trp Ala Ala Val Val 
            260                 265                 270         


Val Pro Ser Gly Glu Glu Gln Arg Tyr Thr Cys His Val Gln His Glu 
        275                 280                 285             


Gly Leu Pro Glu Pro Val Thr Leu Arg Trp Lys Pro Ala Ser Gln Pro 
    290                 295                 300                 


Thr Ile Pro Ile Val Gly Ile Ile Ala Gly Leu Val Leu Leu Gly Ser 
305                 310                 315                 320 


Val Val Ser Gly Ala Val Val Ala Ala Val Ile Trp Arg Lys Lys Ser 
                325                 330                 335     


Ser Gly Gly Lys Gly Gly Ser Tyr Ser Lys Ala Glu Trp Ser Asp Ser 
            340                 345                 350         


Ala Gln Gly Ser Glu Ser His Ser Leu 
        355                 360     


<210>  21
<211>  361
<212>  PRT
<213>  Homo sapiens

<400>  21

Met Leu Val Met Ala Pro Arg Thr Val Leu Leu Leu Leu Ser Ala Ala 
1               5                   10                  15      


Leu Ala Leu Thr Glu Thr Trp Ala Gly Ser His Ser Leu Lys Tyr Phe 
            20                  25                  30          


His Thr Ser Val Ser Arg Pro Gly Arg Gly Glu Pro Arg Phe Ile Ser 
        35                  40                  45              


Val Gly Tyr Val Asp Asp Thr Gln Phe Val Arg Phe Asp Asn Asp Ala 
    50                  55                  60                  


Ala Ser Pro Arg Met Val Pro Arg Ala Pro Trp Met Glu Gln Glu Gly 
65                  70                  75                  80  


Ser Glu Tyr Trp Asp Arg Glu Thr Arg Ser Ala Arg Asp Thr Ala Gln 
                85                  90                  95      


Ile Phe Arg Val Asn Leu Arg Thr Leu Arg Gly Tyr Tyr Asn Gln Ser 
            100                 105                 110         


Glu Ala Gly Ser His Thr Leu Gln Trp Met His Gly Cys Glu Leu Gly 
        115                 120                 125             


Pro Asp Arg Arg Phe Leu Arg Gly Tyr Glu Gln Phe Ala Tyr Asp Gly 
    130                 135                 140                 


Lys Asp Tyr Leu Thr Leu Asn Glu Asp Leu Arg Ser Trp Thr Ala Val 
145                 150                 155                 160 


Asp Thr Ala Ala Gln Ile Ser Glu Gln Lys Ser Asn Asp Ala Ser Glu 
                165                 170                 175     


Ala Glu His Gln Arg Ala Tyr Leu Glu Asp Thr Cys Val Glu Trp Leu 
            180                 185                 190         


His Lys Tyr Leu Glu Lys Gly Lys Glu Thr Leu Leu His Leu Glu Pro 
        195                 200                 205             


Pro Lys Thr His Val Thr His His Pro Ile Ser Asp His Glu Ala Thr 
    210                 215                 220                 


Leu Arg Cys Trp Ala Leu Gly Phe Tyr Pro Ala Glu Ile Thr Leu Thr 
225                 230                 235                 240 


Trp Gln Gln Asp Gly Glu Gly His Thr Gln Asp Thr Glu Leu Val Glu 
                245                 250                 255     


Thr Arg Pro Ala Gly Asp Gly Thr Phe Gln Lys Trp Ala Ala Val Val 
            260                 265                 270         


Val Pro Ser Gly Glu Glu Gln Arg Tyr Thr Cys His Val Gln His Glu 
        275                 280                 285             


Gly Leu Pro Glu Pro Val Thr Leu Arg Trp Lys Pro Ala Ser Gln Pro 
    290                 295                 300                 


Thr Ile Pro Ile Val Gly Ile Ile Ala Gly Leu Val Leu Leu Gly Ser 
305                 310                 315                 320 


Val Val Ser Gly Ala Val Val Ala Ala Val Ile Trp Arg Lys Lys Ser 
                325                 330                 335     


Ser Gly Gly Lys Gly Gly Ser Tyr Ser Lys Ala Glu Trp Ser Asp Ser 
            340                 345                 350         


Ala Gln Gly Ser Glu Ser His Ser Leu 
        355                 360     


<210>  22
<211>  361
<212>  PRT
<213>  Homo sapiens

<400>  22

Met Arg Val Thr Ala Pro Arg Thr Val Leu Leu Leu Leu Ser Gly Ala 
1               5                   10                  15      


Leu Ala Leu Thr Glu Thr Trp Ala Gly Ser His Ser Leu Lys Tyr Phe 
            20                  25                  30          


His Thr Ser Val Ser Arg Pro Gly Arg Gly Glu Pro Arg Phe Ile Ser 
        35                  40                  45              


Val Gly Tyr Val Asp Asp Thr Gln Phe Val Arg Phe Asp Asn Asp Ala 
    50                  55                  60                  


Ala Ser Pro Arg Met Val Pro Arg Ala Pro Trp Met Glu Gln Glu Gly 
65                  70                  75                  80  


Ser Glu Tyr Trp Asp Arg Glu Thr Arg Ser Ala Arg Asp Thr Ala Gln 
                85                  90                  95      


Ile Phe Arg Val Asn Leu Arg Thr Leu Arg Gly Tyr Tyr Asn Gln Ser 
            100                 105                 110         


Glu Ala Gly Ser His Thr Leu Gln Trp Met His Gly Cys Glu Leu Gly 
        115                 120                 125             


Pro Asp Arg Arg Phe Leu Arg Gly Tyr Glu Gln Phe Ala Tyr Asp Gly 
    130                 135                 140                 


Lys Asp Tyr Leu Thr Leu Asn Glu Asp Leu Arg Ser Trp Thr Ala Val 
145                 150                 155                 160 


Asp Thr Ala Ala Gln Ile Ser Glu Gln Lys Ser Asn Asp Ala Ser Glu 
                165                 170                 175     


Ala Glu His Gln Arg Ala Tyr Leu Glu Asp Thr Cys Val Glu Trp Leu 
            180                 185                 190         


His Lys Tyr Leu Glu Lys Gly Lys Glu Thr Leu Leu His Leu Glu Pro 
        195                 200                 205             


Pro Lys Thr His Val Thr His His Pro Ile Ser Asp His Glu Ala Thr 
    210                 215                 220                 


Leu Arg Cys Trp Ala Leu Gly Phe Tyr Pro Ala Glu Ile Thr Leu Thr 
225                 230                 235                 240 


Trp Gln Gln Asp Gly Glu Gly His Thr Gln Asp Thr Glu Leu Val Glu 
                245                 250                 255     


Thr Arg Pro Ala Gly Asp Gly Thr Phe Gln Lys Trp Ala Ala Val Val 
            260                 265                 270         


Val Pro Ser Gly Glu Glu Gln Arg Tyr Thr Cys His Val Gln His Glu 
        275                 280                 285             


Gly Leu Pro Glu Pro Val Thr Leu Arg Trp Lys Pro Ala Ser Gln Pro 
    290                 295                 300                 


Thr Ile Pro Ile Val Gly Ile Ile Ala Gly Leu Val Leu Leu Gly Ser 
305                 310                 315                 320 


Val Val Ser Gly Ala Val Val Ala Ala Val Ile Trp Arg Lys Lys Ser 
                325                 330                 335     


Ser Gly Gly Lys Gly Gly Ser Tyr Ser Lys Ala Glu Trp Ser Asp Ser 
            340                 345                 350         


Ala Gln Gly Ser Glu Ser His Ser Leu 
        355                 360     


<210>  23
<211>  361
<212>  PRT
<213>  Homo sapiens

<400>  23

Met Arg Val Thr Ala Pro Arg Thr Val Leu Leu Leu Leu Ser Ala Ala 
1               5                   10                  15      


Leu Ala Leu Thr Glu Thr Trp Ala Gly Ser His Ser Leu Lys Tyr Phe 
            20                  25                  30          


His Thr Ser Val Ser Arg Pro Gly Arg Gly Glu Pro Arg Phe Ile Ser 
        35                  40                  45              


Val Gly Tyr Val Asp Asp Thr Gln Phe Val Arg Phe Asp Asn Asp Ala 
    50                  55                  60                  


Ala Ser Pro Arg Met Val Pro Arg Ala Pro Trp Met Glu Gln Glu Gly 
65                  70                  75                  80  


Ser Glu Tyr Trp Asp Arg Glu Thr Arg Ser Ala Arg Asp Thr Ala Gln 
                85                  90                  95      


Ile Phe Arg Val Asn Leu Arg Thr Leu Arg Gly Tyr Tyr Asn Gln Ser 
            100                 105                 110         


Glu Ala Gly Ser His Thr Leu Gln Trp Met His Gly Cys Glu Leu Gly 
        115                 120                 125             


Pro Asp Arg Arg Phe Leu Arg Gly Tyr Glu Gln Phe Ala Tyr Asp Gly 
    130                 135                 140                 


Lys Asp Tyr Leu Thr Leu Asn Glu Asp Leu Arg Ser Trp Thr Ala Val 
145                 150                 155                 160 


Asp Thr Ala Ala Gln Ile Ser Glu Gln Lys Ser Asn Asp Ala Ser Glu 
                165                 170                 175     


Ala Glu His Gln Arg Ala Tyr Leu Glu Asp Thr Cys Val Glu Trp Leu 
            180                 185                 190         


His Lys Tyr Leu Glu Lys Gly Lys Glu Thr Leu Leu His Leu Glu Pro 
        195                 200                 205             


Pro Lys Thr His Val Thr His His Pro Ile Ser Asp His Glu Ala Thr 
    210                 215                 220                 


Leu Arg Cys Trp Ala Leu Gly Phe Tyr Pro Ala Glu Ile Thr Leu Thr 
225                 230                 235                 240 


Trp Gln Gln Asp Gly Glu Gly His Thr Gln Asp Thr Glu Leu Val Glu 
                245                 250                 255     


Thr Arg Pro Ala Gly Asp Gly Thr Phe Gln Lys Trp Ala Ala Val Val 
            260                 265                 270         


Val Pro Ser Gly Glu Glu Gln Arg Tyr Thr Cys His Val Gln His Glu 
        275                 280                 285             


Gly Leu Pro Glu Pro Val Thr Leu Arg Trp Lys Pro Ala Ser Gln Pro 
    290                 295                 300                 


Thr Ile Pro Ile Val Gly Ile Ile Ala Gly Leu Val Leu Leu Gly Ser 
305                 310                 315                 320 


Val Val Ser Gly Ala Val Val Ala Ala Val Ile Trp Arg Lys Lys Ser 
                325                 330                 335     


Ser Gly Gly Lys Gly Gly Ser Tyr Ser Lys Ala Glu Trp Ser Asp Ser 
            340                 345                 350         


Ala Gln Gly Ser Glu Ser His Ser Leu 
        355                 360     


<210>  24
<211>  361
<212>  PRT
<213>  Homo sapiens

<400>  24

Met Arg Val Thr Ala Pro Arg Thr Leu Leu Leu Leu Leu Trp Gly Ala 
1               5                   10                  15      


Val Ala Leu Thr Glu Thr Trp Ala Gly Ser His Ser Leu Lys Tyr Phe 
            20                  25                  30          


His Thr Ser Val Ser Arg Pro Gly Arg Gly Glu Pro Arg Phe Ile Ser 
        35                  40                  45              


Val Gly Tyr Val Asp Asp Thr Gln Phe Val Arg Phe Asp Asn Asp Ala 
    50                  55                  60                  


Ala Ser Pro Arg Met Val Pro Arg Ala Pro Trp Met Glu Gln Glu Gly 
65                  70                  75                  80  


Ser Glu Tyr Trp Asp Arg Glu Thr Arg Ser Ala Arg Asp Thr Ala Gln 
                85                  90                  95      


Ile Phe Arg Val Asn Leu Arg Thr Leu Arg Gly Tyr Tyr Asn Gln Ser 
            100                 105                 110         


Glu Ala Gly Ser His Thr Leu Gln Trp Met His Gly Cys Glu Leu Gly 
        115                 120                 125             


Pro Asp Arg Arg Phe Leu Arg Gly Tyr Glu Gln Phe Ala Tyr Asp Gly 
    130                 135                 140                 


Lys Asp Tyr Leu Thr Leu Asn Glu Asp Leu Arg Ser Trp Thr Ala Val 
145                 150                 155                 160 


Asp Thr Ala Ala Gln Ile Ser Glu Gln Lys Ser Asn Asp Ala Ser Glu 
                165                 170                 175     


Ala Glu His Gln Arg Ala Tyr Leu Glu Asp Thr Cys Val Glu Trp Leu 
            180                 185                 190         


His Lys Tyr Leu Glu Lys Gly Lys Glu Thr Leu Leu His Leu Glu Pro 
        195                 200                 205             


Pro Lys Thr His Val Thr His His Pro Ile Ser Asp His Glu Ala Thr 
    210                 215                 220                 


Leu Arg Cys Trp Ala Leu Gly Phe Tyr Pro Ala Glu Ile Thr Leu Thr 
225                 230                 235                 240 


Trp Gln Gln Asp Gly Glu Gly His Thr Gln Asp Thr Glu Leu Val Glu 
                245                 250                 255     


Thr Arg Pro Ala Gly Asp Gly Thr Phe Gln Lys Trp Ala Ala Val Val 
            260                 265                 270         


Val Pro Ser Gly Glu Glu Gln Arg Tyr Thr Cys His Val Gln His Glu 
        275                 280                 285             


Gly Leu Pro Glu Pro Val Thr Leu Arg Trp Lys Pro Ala Ser Gln Pro 
    290                 295                 300                 


Thr Ile Pro Ile Val Gly Ile Ile Ala Gly Leu Val Leu Leu Gly Ser 
305                 310                 315                 320 


Val Val Ser Gly Ala Val Val Ala Ala Val Ile Trp Arg Lys Lys Ser 
                325                 330                 335     


Ser Gly Gly Lys Gly Gly Ser Tyr Ser Lys Ala Glu Trp Ser Asp Ser 
            340                 345                 350         


Ala Gln Gly Ser Glu Ser His Ser Leu 
        355                 360     


<210>  25
<211>  361
<212>  PRT
<213>  Homo sapiens

<400>  25

Met Arg Val Thr Ala Pro Arg Thr Leu Leu Leu Leu Leu Trp Gly Ala 
1               5                   10                  15      


Leu Ala Leu Thr Glu Thr Trp Ala Gly Ser His Ser Leu Lys Tyr Phe 
            20                  25                  30          


His Thr Ser Val Ser Arg Pro Gly Arg Gly Glu Pro Arg Phe Ile Ser 
        35                  40                  45              


Val Gly Tyr Val Asp Asp Thr Gln Phe Val Arg Phe Asp Asn Asp Ala 
    50                  55                  60                  


Ala Ser Pro Arg Met Val Pro Arg Ala Pro Trp Met Glu Gln Glu Gly 
65                  70                  75                  80  


Ser Glu Tyr Trp Asp Arg Glu Thr Arg Ser Ala Arg Asp Thr Ala Gln 
                85                  90                  95      


Ile Phe Arg Val Asn Leu Arg Thr Leu Arg Gly Tyr Tyr Asn Gln Ser 
            100                 105                 110         


Glu Ala Gly Ser His Thr Leu Gln Trp Met His Gly Cys Glu Leu Gly 
        115                 120                 125             


Pro Asp Arg Arg Phe Leu Arg Gly Tyr Glu Gln Phe Ala Tyr Asp Gly 
    130                 135                 140                 


Lys Asp Tyr Leu Thr Leu Asn Glu Asp Leu Arg Ser Trp Thr Ala Val 
145                 150                 155                 160 


Asp Thr Ala Ala Gln Ile Ser Glu Gln Lys Ser Asn Asp Ala Ser Glu 
                165                 170                 175     


Ala Glu His Gln Arg Ala Tyr Leu Glu Asp Thr Cys Val Glu Trp Leu 
            180                 185                 190         


His Lys Tyr Leu Glu Lys Gly Lys Glu Thr Leu Leu His Leu Glu Pro 
        195                 200                 205             


Pro Lys Thr His Val Thr His His Pro Ile Ser Asp His Glu Ala Thr 
    210                 215                 220                 


Leu Arg Cys Trp Ala Leu Gly Phe Tyr Pro Ala Glu Ile Thr Leu Thr 
225                 230                 235                 240 


Trp Gln Gln Asp Gly Glu Gly His Thr Gln Asp Thr Glu Leu Val Glu 
                245                 250                 255     


Thr Arg Pro Ala Gly Asp Gly Thr Phe Gln Lys Trp Ala Ala Val Val 
            260                 265                 270         


Val Pro Ser Gly Glu Glu Gln Arg Tyr Thr Cys His Val Gln His Glu 
        275                 280                 285             


Gly Leu Pro Glu Pro Val Thr Leu Arg Trp Lys Pro Ala Ser Gln Pro 
    290                 295                 300                 


Thr Ile Pro Ile Val Gly Ile Ile Ala Gly Leu Val Leu Leu Gly Ser 
305                 310                 315                 320 


Val Val Ser Gly Ala Val Val Ala Ala Val Ile Trp Arg Lys Lys Ser 
                325                 330                 335     


Ser Gly Gly Lys Gly Gly Ser Tyr Ser Lys Ala Glu Trp Ser Asp Ser 
            340                 345                 350         


Ala Gln Gly Ser Glu Ser His Ser Leu 
        355                 360     


<210>  26
<211>  361
<212>  PRT
<213>  Homo sapiens

<400>  26

Met Arg Val Thr Ala Pro Arg Thr Val Leu Leu Leu Leu Trp Gly Ala 
1               5                   10                  15      


Val Ala Leu Thr Glu Thr Trp Ala Gly Ser His Ser Leu Lys Tyr Phe 
            20                  25                  30          


His Thr Ser Val Ser Arg Pro Gly Arg Gly Glu Pro Arg Phe Ile Ser 
        35                  40                  45              


Val Gly Tyr Val Asp Asp Thr Gln Phe Val Arg Phe Asp Asn Asp Ala 
    50                  55                  60                  


Ala Ser Pro Arg Met Val Pro Arg Ala Pro Trp Met Glu Gln Glu Gly 
65                  70                  75                  80  


Ser Glu Tyr Trp Asp Arg Glu Thr Arg Ser Ala Arg Asp Thr Ala Gln 
                85                  90                  95      


Ile Phe Arg Val Asn Leu Arg Thr Leu Arg Gly Tyr Tyr Asn Gln Ser 
            100                 105                 110         


Glu Ala Gly Ser His Thr Leu Gln Trp Met His Gly Cys Glu Leu Gly 
        115                 120                 125             


Pro Asp Arg Arg Phe Leu Arg Gly Tyr Glu Gln Phe Ala Tyr Asp Gly 
    130                 135                 140                 


Lys Asp Tyr Leu Thr Leu Asn Glu Asp Leu Arg Ser Trp Thr Ala Val 
145                 150                 155                 160 


Asp Thr Ala Ala Gln Ile Ser Glu Gln Lys Ser Asn Asp Ala Ser Glu 
                165                 170                 175     


Ala Glu His Gln Arg Ala Tyr Leu Glu Asp Thr Cys Val Glu Trp Leu 
            180                 185                 190         


His Lys Tyr Leu Glu Lys Gly Lys Glu Thr Leu Leu His Leu Glu Pro 
        195                 200                 205             


Pro Lys Thr His Val Thr His His Pro Ile Ser Asp His Glu Ala Thr 
    210                 215                 220                 


Leu Arg Cys Trp Ala Leu Gly Phe Tyr Pro Ala Glu Ile Thr Leu Thr 
225                 230                 235                 240 


Trp Gln Gln Asp Gly Glu Gly His Thr Gln Asp Thr Glu Leu Val Glu 
                245                 250                 255     


Thr Arg Pro Ala Gly Asp Gly Thr Phe Gln Lys Trp Ala Ala Val Val 
            260                 265                 270         


Val Pro Ser Gly Glu Glu Gln Arg Tyr Thr Cys His Val Gln His Glu 
        275                 280                 285             


Gly Leu Pro Glu Pro Val Thr Leu Arg Trp Lys Pro Ala Ser Gln Pro 
    290                 295                 300                 


Thr Ile Pro Ile Val Gly Ile Ile Ala Gly Leu Val Leu Leu Gly Ser 
305                 310                 315                 320 


Val Val Ser Gly Ala Val Val Ala Ala Val Ile Trp Arg Lys Lys Ser 
                325                 330                 335     


Ser Gly Gly Lys Gly Gly Ser Tyr Ser Lys Ala Glu Trp Ser Asp Ser 
            340                 345                 350         


Ala Gln Gly Ser Glu Ser His Ser Leu 
        355                 360     


<210>  27
<211>  361
<212>  PRT
<213>  Homo sapiens

<400>  27

Met Arg Val Met Ala Pro Arg Thr Leu Ile Leu Leu Leu Ser Gly Ala 
1               5                   10                  15      


Leu Ala Leu Thr Glu Thr Trp Ala Gly Ser His Ser Leu Lys Tyr Phe 
            20                  25                  30          


His Thr Ser Val Ser Arg Pro Gly Arg Gly Glu Pro Arg Phe Ile Ser 
        35                  40                  45              


Val Gly Tyr Val Asp Asp Thr Gln Phe Val Arg Phe Asp Asn Asp Ala 
    50                  55                  60                  


Ala Ser Pro Arg Met Val Pro Arg Ala Pro Trp Met Glu Gln Glu Gly 
65                  70                  75                  80  


Ser Glu Tyr Trp Asp Arg Glu Thr Arg Ser Ala Arg Asp Thr Ala Gln 
                85                  90                  95      


Ile Phe Arg Val Asn Leu Arg Thr Leu Arg Gly Tyr Tyr Asn Gln Ser 
            100                 105                 110         


Glu Ala Gly Ser His Thr Leu Gln Trp Met His Gly Cys Glu Leu Gly 
        115                 120                 125             


Pro Asp Arg Arg Phe Leu Arg Gly Tyr Glu Gln Phe Ala Tyr Asp Gly 
    130                 135                 140                 


Lys Asp Tyr Leu Thr Leu Asn Glu Asp Leu Arg Ser Trp Thr Ala Val 
145                 150                 155                 160 


Asp Thr Ala Ala Gln Ile Ser Glu Gln Lys Ser Asn Asp Ala Ser Glu 
                165                 170                 175     


Ala Glu His Gln Arg Ala Tyr Leu Glu Asp Thr Cys Val Glu Trp Leu 
            180                 185                 190         


His Lys Tyr Leu Glu Lys Gly Lys Glu Thr Leu Leu His Leu Glu Pro 
        195                 200                 205             


Pro Lys Thr His Val Thr His His Pro Ile Ser Asp His Glu Ala Thr 
    210                 215                 220                 


Leu Arg Cys Trp Ala Leu Gly Phe Tyr Pro Ala Glu Ile Thr Leu Thr 
225                 230                 235                 240 


Trp Gln Gln Asp Gly Glu Gly His Thr Gln Asp Thr Glu Leu Val Glu 
                245                 250                 255     


Thr Arg Pro Ala Gly Asp Gly Thr Phe Gln Lys Trp Ala Ala Val Val 
            260                 265                 270         


Val Pro Ser Gly Glu Glu Gln Arg Tyr Thr Cys His Val Gln His Glu 
        275                 280                 285             


Gly Leu Pro Glu Pro Val Thr Leu Arg Trp Lys Pro Ala Ser Gln Pro 
    290                 295                 300                 


Thr Ile Pro Ile Val Gly Ile Ile Ala Gly Leu Val Leu Leu Gly Ser 
305                 310                 315                 320 


Val Val Ser Gly Ala Val Val Ala Ala Val Ile Trp Arg Lys Lys Ser 
                325                 330                 335     


Ser Gly Gly Lys Gly Gly Ser Tyr Ser Lys Ala Glu Trp Ser Asp Ser 
            340                 345                 350         


Ala Gln Gly Ser Glu Ser His Ser Leu 
        355                 360     


<210>  28
<211>  361
<212>  PRT
<213>  Homo sapiens

<400>  28

Met Arg Val Met Ala Pro Arg Ala Leu Leu Leu Leu Leu Ser Gly Gly 
1               5                   10                  15      


Leu Ala Leu Thr Glu Thr Trp Ala Gly Ser His Ser Leu Lys Tyr Phe 
            20                  25                  30          


His Thr Ser Val Ser Arg Pro Gly Arg Gly Glu Pro Arg Phe Ile Ser 
        35                  40                  45              


Val Gly Tyr Val Asp Asp Thr Gln Phe Val Arg Phe Asp Asn Asp Ala 
    50                  55                  60                  


Ala Ser Pro Arg Met Val Pro Arg Ala Pro Trp Met Glu Gln Glu Gly 
65                  70                  75                  80  


Ser Glu Tyr Trp Asp Arg Glu Thr Arg Ser Ala Arg Asp Thr Ala Gln 
                85                  90                  95      


Ile Phe Arg Val Asn Leu Arg Thr Leu Arg Gly Tyr Tyr Asn Gln Ser 
            100                 105                 110         


Glu Ala Gly Ser His Thr Leu Gln Trp Met His Gly Cys Glu Leu Gly 
        115                 120                 125             


Pro Asp Arg Arg Phe Leu Arg Gly Tyr Glu Gln Phe Ala Tyr Asp Gly 
    130                 135                 140                 


Lys Asp Tyr Leu Thr Leu Asn Glu Asp Leu Arg Ser Trp Thr Ala Val 
145                 150                 155                 160 


Asp Thr Ala Ala Gln Ile Ser Glu Gln Lys Ser Asn Asp Ala Ser Glu 
                165                 170                 175     


Ala Glu His Gln Arg Ala Tyr Leu Glu Asp Thr Cys Val Glu Trp Leu 
            180                 185                 190         


His Lys Tyr Leu Glu Lys Gly Lys Glu Thr Leu Leu His Leu Glu Pro 
        195                 200                 205             


Pro Lys Thr His Val Thr His His Pro Ile Ser Asp His Glu Ala Thr 
    210                 215                 220                 


Leu Arg Cys Trp Ala Leu Gly Phe Tyr Pro Ala Glu Ile Thr Leu Thr 
225                 230                 235                 240 


Trp Gln Gln Asp Gly Glu Gly His Thr Gln Asp Thr Glu Leu Val Glu 
                245                 250                 255     


Thr Arg Pro Ala Gly Asp Gly Thr Phe Gln Lys Trp Ala Ala Val Val 
            260                 265                 270         


Val Pro Ser Gly Glu Glu Gln Arg Tyr Thr Cys His Val Gln His Glu 
        275                 280                 285             


Gly Leu Pro Glu Pro Val Thr Leu Arg Trp Lys Pro Ala Ser Gln Pro 
    290                 295                 300                 


Thr Ile Pro Ile Val Gly Ile Ile Ala Gly Leu Val Leu Leu Gly Ser 
305                 310                 315                 320 


Val Val Ser Gly Ala Val Val Ala Ala Val Ile Trp Arg Lys Lys Ser 
                325                 330                 335     


Ser Gly Gly Lys Gly Gly Ser Tyr Ser Lys Ala Glu Trp Ser Asp Ser 
            340                 345                 350         


Ala Gln Gly Ser Glu Ser His Ser Leu 
        355                 360     


<210>  29
<211>  361
<212>  PRT
<213>  Homo sapiens

<400>  29

Met Arg Val Met Ala Pro Arg Thr Leu Leu Leu Leu Leu Ser Gly Ala 
1               5                   10                  15      


Leu Ala Leu Thr Glu Thr Trp Ala Gly Ser His Ser Leu Lys Tyr Phe 
            20                  25                  30          


His Thr Ser Val Ser Arg Pro Gly Arg Gly Glu Pro Arg Phe Ile Ser 
        35                  40                  45              


Val Gly Tyr Val Asp Asp Thr Gln Phe Val Arg Phe Asp Asn Asp Ala 
    50                  55                  60                  


Ala Ser Pro Arg Met Val Pro Arg Ala Pro Trp Met Glu Gln Glu Gly 
65                  70                  75                  80  


Ser Glu Tyr Trp Asp Arg Glu Thr Arg Ser Ala Arg Asp Thr Ala Gln 
                85                  90                  95      


Ile Phe Arg Val Asn Leu Arg Thr Leu Arg Gly Tyr Tyr Asn Gln Ser 
            100                 105                 110         


Glu Ala Gly Ser His Thr Leu Gln Trp Met His Gly Cys Glu Leu Gly 
        115                 120                 125             


Pro Asp Arg Arg Phe Leu Arg Gly Tyr Glu Gln Phe Ala Tyr Asp Gly 
    130                 135                 140                 


Lys Asp Tyr Leu Thr Leu Asn Glu Asp Leu Arg Ser Trp Thr Ala Val 
145                 150                 155                 160 


Asp Thr Ala Ala Gln Ile Ser Glu Gln Lys Ser Asn Asp Ala Ser Glu 
                165                 170                 175     


Ala Glu His Gln Arg Ala Tyr Leu Glu Asp Thr Cys Val Glu Trp Leu 
            180                 185                 190         


His Lys Tyr Leu Glu Lys Gly Lys Glu Thr Leu Leu His Leu Glu Pro 
        195                 200                 205             


Pro Lys Thr His Val Thr His His Pro Ile Ser Asp His Glu Ala Thr 
    210                 215                 220                 


Leu Arg Cys Trp Ala Leu Gly Phe Tyr Pro Ala Glu Ile Thr Leu Thr 
225                 230                 235                 240 


Trp Gln Gln Asp Gly Glu Gly His Thr Gln Asp Thr Glu Leu Val Glu 
                245                 250                 255     


Thr Arg Pro Ala Gly Asp Gly Thr Phe Gln Lys Trp Ala Ala Val Val 
            260                 265                 270         


Val Pro Ser Gly Glu Glu Gln Arg Tyr Thr Cys His Val Gln His Glu 
        275                 280                 285             


Gly Leu Pro Glu Pro Val Thr Leu Arg Trp Lys Pro Ala Ser Gln Pro 
    290                 295                 300                 


Thr Ile Pro Ile Val Gly Ile Ile Ala Gly Leu Val Leu Leu Gly Ser 
305                 310                 315                 320 


Val Val Ser Gly Ala Val Val Ala Ala Val Ile Trp Arg Lys Lys Ser 
                325                 330                 335     


Ser Gly Gly Lys Gly Gly Ser Tyr Ser Lys Ala Glu Trp Ser Asp Ser 
            340                 345                 350         


Ala Gln Gly Ser Glu Ser His Ser Leu 
        355                 360     


<210>  30
<211>  361
<212>  PRT
<213>  Homo sapiens

<400>  30

Met Arg Val Met Ala Pro Gln Ala Leu Leu Leu Leu Leu Ser Gly Ala 
1               5                   10                  15      


Leu Ala Leu Ile Glu Thr Trp Ala Gly Ser His Ser Leu Lys Tyr Phe 
            20                  25                  30          


His Thr Ser Val Ser Arg Pro Gly Arg Gly Glu Pro Arg Phe Ile Ser 
        35                  40                  45              


Val Gly Tyr Val Asp Asp Thr Gln Phe Val Arg Phe Asp Asn Asp Ala 
    50                  55                  60                  


Ala Ser Pro Arg Met Val Pro Arg Ala Pro Trp Met Glu Gln Glu Gly 
65                  70                  75                  80  


Ser Glu Tyr Trp Asp Arg Glu Thr Arg Ser Ala Arg Asp Thr Ala Gln 
                85                  90                  95      


Ile Phe Arg Val Asn Leu Arg Thr Leu Arg Gly Tyr Tyr Asn Gln Ser 
            100                 105                 110         


Glu Ala Gly Ser His Thr Leu Gln Trp Met His Gly Cys Glu Leu Gly 
        115                 120                 125             


Pro Asp Arg Arg Phe Leu Arg Gly Tyr Glu Gln Phe Ala Tyr Asp Gly 
    130                 135                 140                 


Lys Asp Tyr Leu Thr Leu Asn Glu Asp Leu Arg Ser Trp Thr Ala Val 
145                 150                 155                 160 


Asp Thr Ala Ala Gln Ile Ser Glu Gln Lys Ser Asn Asp Ala Ser Glu 
                165                 170                 175     


Ala Glu His Gln Arg Ala Tyr Leu Glu Asp Thr Cys Val Glu Trp Leu 
            180                 185                 190         


His Lys Tyr Leu Glu Lys Gly Lys Glu Thr Leu Leu His Leu Glu Pro 
        195                 200                 205             


Pro Lys Thr His Val Thr His His Pro Ile Ser Asp His Glu Ala Thr 
    210                 215                 220                 


Leu Arg Cys Trp Ala Leu Gly Phe Tyr Pro Ala Glu Ile Thr Leu Thr 
225                 230                 235                 240 


Trp Gln Gln Asp Gly Glu Gly His Thr Gln Asp Thr Glu Leu Val Glu 
                245                 250                 255     


Thr Arg Pro Ala Gly Asp Gly Thr Phe Gln Lys Trp Ala Ala Val Val 
            260                 265                 270         


Val Pro Ser Gly Glu Glu Gln Arg Tyr Thr Cys His Val Gln His Glu 
        275                 280                 285             


Gly Leu Pro Glu Pro Val Thr Leu Arg Trp Lys Pro Ala Ser Gln Pro 
    290                 295                 300                 


Thr Ile Pro Ile Val Gly Ile Ile Ala Gly Leu Val Leu Leu Gly Ser 
305                 310                 315                 320 


Val Val Ser Gly Ala Val Val Ala Ala Val Ile Trp Arg Lys Lys Ser 
                325                 330                 335     


Ser Gly Gly Lys Gly Gly Ser Tyr Ser Lys Ala Glu Trp Ser Asp Ser 
            340                 345                 350         


Ala Gln Gly Ser Glu Ser His Ser Leu 
        355                 360     


<210>  31
<211>  358
<212>  PRT
<213>  Homo sapiens

<400>  31

Met Val Asp Gly Thr Leu Leu Leu Leu Leu Ser Glu Ala Leu Ala Leu 
1               5                   10                  15      


Thr Gln Thr Trp Ala Gly Ser His Ser Leu Lys Tyr Phe His Thr Ser 
            20                  25                  30          


Val Ser Arg Pro Gly Arg Gly Glu Pro Arg Phe Ile Ser Val Gly Tyr 
        35                  40                  45              


Val Asp Asp Thr Gln Phe Val Arg Phe Asp Asn Asp Ala Ala Ser Pro 
    50                  55                  60                  


Arg Met Val Pro Arg Ala Pro Trp Met Glu Gln Glu Gly Ser Glu Tyr 
65                  70                  75                  80  


Trp Asp Arg Glu Thr Arg Ser Ala Arg Asp Thr Ala Gln Ile Phe Arg 
                85                  90                  95      


Val Asn Leu Arg Thr Leu Arg Gly Tyr Tyr Asn Gln Ser Glu Ala Gly 
            100                 105                 110         


Ser His Thr Leu Gln Trp Met His Gly Cys Glu Leu Gly Pro Asp Gly 
        115                 120                 125             


Arg Phe Leu Arg Gly Tyr Glu Gln Phe Ala Tyr Asp Gly Lys Asp Tyr 
    130                 135                 140                 


Leu Thr Leu Asn Glu Asp Leu Arg Ser Trp Thr Ala Val Asp Thr Ala 
145                 150                 155                 160 


Ala Gln Ile Ser Glu Gln Lys Ser Asn Asp Ala Ser Glu Ala Glu His 
                165                 170                 175     


Gln Arg Ala Tyr Leu Glu Asp Thr Cys Val Glu Trp Leu His Lys Tyr 
            180                 185                 190         


Leu Glu Lys Gly Lys Glu Thr Leu Leu His Leu Glu Pro Pro Lys Thr 
        195                 200                 205             


His Val Thr His His Pro Ile Ser Asp His Glu Ala Thr Leu Arg Cys 
    210                 215                 220                 


Trp Ala Leu Gly Phe Tyr Pro Ala Glu Ile Thr Leu Thr Trp Gln Gln 
225                 230                 235                 240 


Asp Gly Glu Gly His Thr Gln Asp Thr Glu Leu Val Glu Thr Arg Pro 
                245                 250                 255     


Ala Gly Asp Gly Thr Phe Gln Lys Trp Ala Ala Val Val Val Pro Ser 
            260                 265                 270         


Gly Glu Glu Gln Arg Tyr Thr Cys His Val Gln His Glu Gly Leu Pro 
        275                 280                 285             


Glu Pro Val Thr Leu Arg Trp Lys Pro Ala Ser Gln Pro Thr Ile Pro 
    290                 295                 300                 


Ile Val Gly Ile Ile Ala Gly Leu Val Leu Leu Gly Ser Val Val Ser 
305                 310                 315                 320 


Gly Ala Val Val Ala Ala Val Ile Trp Arg Lys Lys Ser Ser Gly Gly 
                325                 330                 335     


Lys Gly Gly Ser Tyr Ser Lys Ala Glu Trp Ser Asp Ser Ala Gln Gly 
            340                 345                 350         


Ser Glu Ser His Ser Leu 
        355             


<210>  32
<211>  358
<212>  PRT
<213>  Homo sapiens

<400>  32

Met Val Asp Gly Thr Leu Leu Leu Leu Leu Ser Glu Ala Leu Ala Leu 
1               5                   10                  15      


Thr Gln Thr Trp Ala Gly Ser His Ser Leu Lys Tyr Phe His Thr Ser 
            20                  25                  30          


Val Ser Arg Pro Gly Arg Gly Glu Pro Arg Phe Ile Ser Val Gly Tyr 
        35                  40                  45              


Val Asp Asp Thr Gln Phe Val Arg Phe Asp Asn Asp Ala Ala Ser Pro 
    50                  55                  60                  


Arg Met Val Pro Arg Ala Pro Trp Met Glu Gln Glu Gly Ser Glu Tyr 
65                  70                  75                  80  


Trp Asp Arg Glu Thr Arg Ser Ala Arg Asp Thr Ala Gln Ile Phe Arg 
                85                  90                  95      


Val Asn Leu Arg Thr Leu Arg Gly Tyr Tyr Asn Gln Ser Glu Ala Gly 
            100                 105                 110         


Ser His Thr Leu Gln Trp Met His Gly Cys Glu Leu Gly Pro Asp Arg 
        115                 120                 125             


Arg Phe Leu Arg Gly Tyr Glu Gln Phe Ala Tyr Asp Gly Lys Asp Tyr 
    130                 135                 140                 


Leu Thr Leu Asn Glu Asp Leu Arg Ser Trp Thr Ala Val Asp Thr Ala 
145                 150                 155                 160 


Ala Gln Ile Ser Glu Gln Lys Ser Asn Asp Ala Ser Glu Ala Glu His 
                165                 170                 175     


Gln Arg Ala Tyr Leu Glu Asp Thr Cys Val Glu Trp Leu His Lys Tyr 
            180                 185                 190         


Leu Glu Lys Gly Lys Glu Thr Leu Leu His Leu Glu Pro Pro Lys Thr 
        195                 200                 205             


His Val Thr His His Pro Ile Ser Asp His Glu Ala Thr Leu Arg Cys 
    210                 215                 220                 


Trp Ala Leu Gly Phe Tyr Pro Ala Glu Ile Thr Leu Thr Trp Gln Gln 
225                 230                 235                 240 


Asp Gly Glu Gly His Thr Gln Asp Thr Glu Leu Val Glu Thr Arg Pro 
                245                 250                 255     


Ala Gly Asp Gly Thr Phe Gln Lys Trp Ala Ala Val Val Val Pro Ser 
            260                 265                 270         


Gly Glu Glu Gln Arg Tyr Thr Cys His Val Gln His Glu Gly Leu Pro 
        275                 280                 285             


Glu Pro Val Thr Leu Arg Trp Lys Pro Ala Ser Gln Pro Thr Ile Pro 
    290                 295                 300                 


Ile Val Gly Ile Ile Ala Gly Leu Val Leu Leu Gly Ser Val Val Ser 
305                 310                 315                 320 


Gly Ala Val Val Ala Ala Val Ile Trp Arg Lys Lys Ser Ser Gly Gly 
                325                 330                 335     


Lys Gly Gly Ser Tyr Ser Lys Ala Glu Trp Ser Asp Ser Ala Gln Gly 
            340                 345                 350         


Ser Glu Ser His Ser Leu 
        355             


<210>  33
<211>  24
<212>  PRT
<213>  Homo sapiens

<400>  33

Met Val Val Met Ala Pro Arg Thr Leu Phe Leu Leu Leu Ser Gly Ala 
1               5                   10                  15      


Leu Thr Leu Thr Glu Thr Trp Ala 
            20                  


<210>  34
<211>  24
<212>  PRT
<213>  Homo sapiens

<400>  34

Met Ala Val Met Ala Pro Arg Thr Leu Leu Leu Leu Leu Ser Gly Ala 
1               5                   10                  15      


Leu Ala Leu Thr Gln Thr Trp Ala 
            20                  


<210>  35
<211>  24
<212>  PRT
<213>  Homo sapiens

<400>  35

Met Ala Val Met Ala Pro Arg Thr Leu Val Leu Leu Leu Ser Gly Ala 
1               5                   10                  15      


Leu Ala Leu Thr Gln Thr Trp Ala 
            20                  


<210>  36
<211>  24
<212>  PRT
<213>  Homo sapiens

<400>  36

Met Ala Val Met Ala Pro Arg Thr Leu Leu Leu Leu Leu Leu Gly Ala 
1               5                   10                  15      


Leu Ala Leu Thr Gln Thr Trp Ala 
            20                  


<210>  37
<211>  24
<212>  PRT
<213>  Homo sapiens

<400>  37

Met Ala Ile Met Ala Pro Arg Thr Leu Val Leu Leu Leu Ser Gly Ala 
1               5                   10                  15      


Leu Ala Leu Thr Gln Thr Trp Ala 
            20                  


<210>  38
<211>  24
<212>  PRT
<213>  Homo sapiens

<400>  38

Met Leu Val Met Ala Pro Arg Thr Val Leu Leu Leu Leu Ser Ala Ala 
1               5                   10                  15      


Leu Ala Leu Thr Glu Thr Trp Ala 
            20                  


<210>  39
<211>  24
<212>  PRT
<213>  Homo sapiens

<400>  39

Met Arg Val Thr Ala Pro Arg Thr Val Leu Leu Leu Leu Ser Gly Ala 
1               5                   10                  15      


Leu Ala Leu Thr Glu Thr Trp Ala 
            20                  


<210>  40
<211>  24
<212>  PRT
<213>  Homo sapiens

<400>  40

Met Arg Val Thr Ala Pro Arg Thr Val Leu Leu Leu Leu Ser Ala Ala 
1               5                   10                  15      


Leu Ala Leu Thr Glu Thr Trp Ala 
            20                  


<210>  41
<211>  24
<212>  PRT
<213>  Homo sapiens

<400>  41

Met Arg Val Thr Ala Pro Arg Thr Leu Leu Leu Leu Leu Trp Gly Ala 
1               5                   10                  15      


Val Ala Leu Thr Glu Thr Trp Ala 
            20                  


<210>  42
<211>  24
<212>  PRT
<213>  Homo sapiens

<400>  42

Met Arg Val Thr Ala Pro Arg Thr Leu Leu Leu Leu Leu Trp Gly Ala 
1               5                   10                  15      


Leu Ala Leu Thr Glu Thr Trp Ala 
            20                  


<210>  43
<211>  24
<212>  PRT
<213>  Homo sapiens

<400>  43

Met Arg Val Thr Ala Pro Arg Thr Val Leu Leu Leu Leu Trp Gly Ala 
1               5                   10                  15      


Val Ala Leu Thr Glu Thr Trp Ala 
            20                  


<210>  44
<211>  24
<212>  PRT
<213>  Homo sapiens

<400>  44

Met Arg Val Met Ala Pro Arg Thr Leu Ile Leu Leu Leu Ser Gly Ala 
1               5                   10                  15      


Leu Ala Leu Thr Glu Thr Trp Ala 
            20                  


<210>  45
<211>  24
<212>  PRT
<213>  Homo sapiens

<400>  45

Met Arg Val Met Ala Pro Arg Ala Leu Leu Leu Leu Leu Ser Gly Gly 
1               5                   10                  15      


Leu Ala Leu Thr Glu Thr Trp Ala 
            20                  


<210>  46
<211>  24
<212>  PRT
<213>  Homo sapiens

<400>  46

Met Arg Val Met Ala Pro Arg Thr Leu Leu Leu Leu Leu Ser Gly Ala 
1               5                   10                  15      


Leu Ala Leu Thr Glu Thr Trp Ala 
            20                  


<210>  47
<211>  24
<212>  PRT
<213>  Homo sapiens

<400>  47

Met Arg Val Met Ala Pro Gln Ala Leu Leu Leu Leu Leu Ser Gly Ala 
1               5                   10                  15      


Leu Ala Leu Ile Glu Thr Trp Ala 
            20                  


<210>  48
<211>  338
<212>  PRT
<213>  Homo sapiens

<400>  48

Met Val Val Met Ala Pro Arg Thr Leu Phe Leu Leu Leu Ser Gly Ala 
1               5                   10                  15      


Leu Thr Leu Thr Glu Thr Trp Ala Gly Ser His Ser Met Arg Tyr Phe 
            20                  25                  30          


Ser Ala Ala Val Ser Arg Pro Gly Arg Gly Glu Pro Arg Phe Ile Ala 
        35                  40                  45              


Met Gly Tyr Val Asp Asp Thr Gln Phe Val Arg Phe Asp Ser Asp Ser 
    50                  55                  60                  


Ala Cys Pro Arg Met Glu Pro Arg Ala Pro Trp Val Glu Gln Glu Gly 
65                  70                  75                  80  


Pro Glu Tyr Trp Glu Glu Glu Thr Arg Asn Thr Lys Ala His Ala Gln 
                85                  90                  95      


Thr Asp Arg Met Asn Leu Gln Thr Leu Arg Gly Tyr Tyr Asn Gln Ser 
            100                 105                 110         


Glu Ala Ser Ser His Thr Leu Gln Trp Met Ile Gly Cys Asp Leu Gly 
        115                 120                 125             


Ser Asp Gly Arg Leu Leu Arg Gly Tyr Glu Gln Tyr Ala Tyr Asp Gly 
    130                 135                 140                 


Lys Asp Tyr Leu Ala Leu Asn Glu Asp Leu Arg Ser Trp Thr Ala Ala 
145                 150                 155                 160 


Asp Thr Ala Ala Gln Ile Ser Lys Arg Lys Cys Glu Ala Ala Asn Val 
                165                 170                 175     


Ala Glu Gln Arg Arg Ala Tyr Leu Glu Gly Thr Cys Val Glu Trp Leu 
            180                 185                 190         


His Arg Tyr Leu Glu Asn Gly Lys Glu Met Leu Gln Arg Ala Asp Pro 
        195                 200                 205             


Pro Lys Thr His Val Thr His His Pro Val Phe Asp Tyr Glu Ala Thr 
    210                 215                 220                 


Leu Arg Cys Trp Ala Leu Gly Phe Tyr Pro Ala Glu Ile Ile Leu Thr 
225                 230                 235                 240 


Trp Gln Arg Asp Gly Glu Asp Gln Thr Gln Asp Val Glu Leu Val Glu 
                245                 250                 255     


Thr Arg Pro Ala Gly Asp Gly Thr Phe Gln Lys Trp Ala Ala Val Val 
            260                 265                 270         


Val Pro Ser Gly Glu Glu Gln Arg Tyr Thr Cys His Val Gln His Glu 
        275                 280                 285             


Gly Leu Pro Glu Pro Leu Met Leu Arg Trp Lys Gln Ser Ser Leu Pro 
    290                 295                 300                 


Thr Ile Pro Ile Met Gly Ile Val Ala Gly Leu Val Val Leu Ala Ala 
305                 310                 315                 320 


Val Val Thr Gly Ala Ala Val Ala Ala Val Leu Trp Arg Lys Lys Ser 
                325                 330                 335     


Ser Asp 
        


<210>  49
<211>  22
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Forward primer

<400>  49
gggaccagac gggagattcc tg                                                22


<210>  50
<211>  18
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Reverse primer

<400>  50
agctcgcatc cgtgcatc                                                     18


