                         SEQUENCE LISTING

<110>  The Trustees of the University of Pennsylvania
 
<120>  COMPOSITIONS USEFUL FOR TREATING SPINAL AND BULBAR MUSCULAR 
       ATROPHY (SBMA)

<130>  UPN-21-9557.PCT

<150>  US 63/173885
<151>  2021-04-12

<150>  US 63/187883
<151>  2021-05-12

<150>  US 63/293505
<151>  2021-12-23

<160>  27    

<170>  PatentIn version 3.5

<210>  1
<211>  21
<212>  DNA
<213>  Homo sapiens

<400>  1
gaactacatc aaggaactcg a                                                 21


<210>  2
<211>  21
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  constructed sequence

<400>  2
tcgagttcct tgatgtagtt c                                                 21


<210>  3
<211>  21
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  constructed sequence

<400>  3
cgatcgagtt ccttgatgta g                                                 21


<210>  4
<211>  64
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  constructed sequence

<400>  4
tgctgtcgag ttccttgatg tagttcgttt tggccactga ctgacgaact acaaaggaac       60

tcga                                                                    64


<210>  5
<211>  64
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  constructed sequence

<400>  5
tgctgcgatc gagttccttg atgtaggttt tggccactga ctgacctaca tcagaactcg       60

atcg                                                                    64


<210>  6
<211>  920
<212>  PRT
<213>  Homo sapiens

<400>  6

Met Glu Val Gln Leu Gly Leu Gly Arg Val Tyr Pro Arg Pro Pro Ser 
1               5                   10                  15      


Lys Thr Tyr Arg Gly Ala Phe Gln Asn Leu Phe Gln Ser Val Arg Glu 
            20                  25                  30          


Val Ile Gln Asn Pro Gly Pro Arg His Pro Glu Ala Ala Ser Ala Ala 
        35                  40                  45              


Pro Pro Gly Ala Ser Leu Leu Leu Leu Gln Gln Gln Gln Gln Gln Gln 
    50                  55                  60                  


Gln Gln Gln Gln Gln Gln Gln Gln Gln Gln Gln Gln Gln Gln Gln Gln 
65                  70                  75                  80  


Glu Thr Ser Pro Arg Gln Gln Gln Gln Gln Gln Gly Glu Asp Gly Ser 
                85                  90                  95      


Pro Gln Ala His Arg Arg Gly Pro Thr Gly Tyr Leu Val Leu Asp Glu 
            100                 105                 110         


Glu Gln Gln Pro Ser Gln Pro Gln Ser Ala Leu Glu Cys His Pro Glu 
        115                 120                 125             


Arg Gly Cys Val Pro Glu Pro Gly Ala Ala Val Ala Ala Ser Lys Gly 
    130                 135                 140                 


Leu Pro Gln Gln Leu Pro Ala Pro Pro Asp Glu Asp Asp Ser Ala Ala 
145                 150                 155                 160 


Pro Ser Thr Leu Ser Leu Leu Gly Pro Thr Phe Pro Gly Leu Ser Ser 
                165                 170                 175     


Cys Ser Ala Asp Leu Lys Asp Ile Leu Ser Glu Ala Ser Thr Met Gln 
            180                 185                 190         


Leu Leu Gln Gln Gln Gln Gln Glu Ala Val Ser Glu Gly Ser Ser Ser 
        195                 200                 205             


Gly Arg Ala Arg Glu Ala Ser Gly Ala Pro Thr Ser Ser Lys Asp Asn 
    210                 215                 220                 


Tyr Leu Gly Gly Thr Ser Thr Ile Ser Asp Asn Ala Lys Glu Leu Cys 
225                 230                 235                 240 


Lys Ala Val Ser Val Ser Met Gly Leu Gly Val Glu Ala Leu Glu His 
                245                 250                 255     


Leu Ser Pro Gly Glu Gln Leu Arg Gly Asp Cys Met Tyr Ala Pro Leu 
            260                 265                 270         


Leu Gly Val Pro Pro Ala Val Arg Pro Thr Pro Cys Ala Pro Leu Ala 
        275                 280                 285             


Glu Cys Lys Gly Ser Leu Leu Asp Asp Ser Ala Gly Lys Ser Thr Glu 
    290                 295                 300                 


Asp Thr Ala Glu Tyr Ser Pro Phe Lys Gly Gly Tyr Thr Lys Gly Leu 
305                 310                 315                 320 


Glu Gly Glu Ser Leu Gly Cys Ser Gly Ser Ala Ala Ala Gly Ser Ser 
                325                 330                 335     


Gly Thr Leu Glu Leu Pro Ser Thr Leu Ser Leu Tyr Lys Ser Gly Ala 
            340                 345                 350         


Leu Asp Glu Ala Ala Ala Tyr Gln Ser Arg Asp Tyr Tyr Asn Phe Pro 
        355                 360                 365             


Leu Ala Leu Ala Gly Pro Pro Pro Pro Pro Pro Pro Pro His Pro His 
    370                 375                 380                 


Ala Arg Ile Lys Leu Glu Asn Pro Leu Asp Tyr Gly Ser Ala Trp Ala 
385                 390                 395                 400 


Ala Ala Ala Ala Gln Cys Arg Tyr Gly Asp Leu Ala Ser Leu His Gly 
                405                 410                 415     


Ala Gly Ala Ala Gly Pro Gly Ser Gly Ser Pro Ser Ala Ala Ala Ser 
            420                 425                 430         


Ser Ser Trp His Thr Leu Phe Thr Ala Glu Glu Gly Gln Leu Tyr Gly 
        435                 440                 445             


Pro Cys Gly Gly Gly Gly Gly Gly Gly Gly Gly Gly Gly Gly Gly Gly 
    450                 455                 460                 


Gly Gly Gly Gly Gly Gly Gly Gly Gly Glu Ala Gly Ala Val Ala Pro 
465                 470                 475                 480 


Tyr Gly Tyr Thr Arg Pro Pro Gln Gly Leu Ala Gly Gln Glu Ser Asp 
                485                 490                 495     


Phe Thr Ala Pro Asp Val Trp Tyr Pro Gly Gly Met Val Ser Arg Val 
            500                 505                 510         


Pro Tyr Pro Ser Pro Thr Cys Val Lys Ser Glu Met Gly Pro Trp Met 
        515                 520                 525             


Asp Ser Tyr Ser Gly Pro Tyr Gly Asp Met Arg Leu Glu Thr Ala Arg 
    530                 535                 540                 


Asp His Val Leu Pro Ile Asp Tyr Tyr Phe Pro Pro Gln Lys Thr Cys 
545                 550                 555                 560 


Leu Ile Cys Gly Asp Glu Ala Ser Gly Cys His Tyr Gly Ala Leu Thr 
                565                 570                 575     


Cys Gly Ser Cys Lys Val Phe Phe Lys Arg Ala Ala Glu Gly Lys Gln 
            580                 585                 590         


Lys Tyr Leu Cys Ala Ser Arg Asn Asp Cys Thr Ile Asp Lys Phe Arg 
        595                 600                 605             


Arg Lys Asn Cys Pro Ser Cys Arg Leu Arg Lys Cys Tyr Glu Ala Gly 
    610                 615                 620                 


Met Thr Leu Gly Ala Arg Lys Leu Lys Lys Leu Gly Asn Leu Lys Leu 
625                 630                 635                 640 


Gln Glu Glu Gly Glu Ala Ser Ser Thr Thr Ser Pro Thr Glu Glu Thr 
                645                 650                 655     


Thr Gln Lys Leu Thr Val Ser His Ile Glu Gly Tyr Glu Cys Gln Pro 
            660                 665                 670         


Ile Phe Leu Asn Val Leu Glu Ala Ile Glu Pro Gly Val Val Cys Ala 
        675                 680                 685             


Gly His Asp Asn Asn Gln Pro Asp Ser Phe Ala Ala Leu Leu Ser Ser 
    690                 695                 700                 


Leu Asn Glu Leu Gly Glu Arg Gln Leu Val His Val Val Lys Trp Ala 
705                 710                 715                 720 


Lys Ala Leu Pro Gly Phe Arg Asn Leu His Val Asp Asp Gln Met Ala 
                725                 730                 735     


Val Ile Gln Tyr Ser Trp Met Gly Leu Met Val Phe Ala Met Gly Trp 
            740                 745                 750         


Arg Ser Phe Thr Asn Val Asn Ser Arg Met Leu Tyr Phe Ala Pro Asp 
        755                 760                 765             


Leu Val Phe Asn Glu Tyr Arg Met His Lys Ser Arg Met Tyr Ser Gln 
    770                 775                 780                 


Cys Val Arg Met Arg His Leu Ser Gln Glu Phe Gly Trp Leu Gln Ile 
785                 790                 795                 800 


Thr Pro Gln Glu Phe Leu Cys Met Lys Ala Leu Leu Leu Phe Ser Ile 
                805                 810                 815     


Ile Pro Val Asp Gly Leu Lys Asn Gln Lys Phe Phe Asp Glu Leu Arg 
            820                 825                 830         


Met Asn Tyr Ile Lys Glu Leu Asp Arg Ile Ile Ala Cys Lys Arg Lys 
        835                 840                 845             


Asn Pro Thr Ser Cys Ser Arg Arg Phe Tyr Gln Leu Thr Lys Leu Leu 
    850                 855                 860                 


Asp Ser Val Gln Pro Ile Ala Arg Glu Leu His Gln Phe Thr Phe Asp 
865                 870                 875                 880 


Leu Leu Ile Lys Ser His Met Val Ser Val Asp Phe Pro Glu Met Met 
                885                 890                 895     


Ala Glu Ile Ile Ser Val Gln Val Pro Lys Ile Leu Ser Gly Lys Val 
            900                 905                 910         


Lys Pro Ile Tyr Phe His Thr Gln 
        915                 920 


<210>  7
<211>  130
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  constructed sequence

<400>  7
ctgcgcgctc gctcgctcac tgaggccgcc cgggcaaagc ccgggcgtcg ggcgaccttt       60

ggtcgcccgg cctcagtgag cgagcgagcg cgcagagagg gagtggccaa ctccatcact      120

aggggttcct                                                             130


<210>  8
<211>  304
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  constructed sequence

<400>  8
cgttacataa cttacggtaa atggcccgcc tggctgaccg cccaacgacc cccgcccatt       60

gacgtcaata atgacgtatg ttcccatagt aacgccaata gggactttcc attgacgtca      120

atgggtggag tatttacggt aaactgccca cttggcagta catcaagtgt atcatatgcc      180

aagtacgccc cctattgacg tcaatgacgg taaatggccc gcctggcatt atgcccagta      240

catgacctta tgggactttc ctacttggca gtacatctac gtattagtca tcgctattac      300

catg                                                                   304


<210>  9
<211>  278
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  constructed sequence

<400>  9
tcgaggtgag ccccacgttc tgcttcactc tccccatctc ccccccctcc ccacccccaa       60

ttttgtattt atttattttt taattatttt gtgcagcgat gggggcgggg gggggggggg      120

ggcgcgcgcc aggcggggcg gggcggggcg aggggcgggg cggggcgagg cggagaggtg      180

cggcggcagc caatcagagc ggcgcgctcc gaaagtttcc ttttatggcg aggcggcggc      240

ggcggcggcc ctataaaaag cgaagcgcgc ggcgggcg                              278


<210>  10
<211>  973
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  constructed sequence

<400>  10
gtgagcgggc gggacggccc ttctcctccg ggctgtaatt agcgcttggt ttaatgacgg       60

cttgtttctt ttctgtggct gcgtgaaagc cttgaggggc tccgggaggg ccctttgtgc      120

ggggggagcg gctcgggggg tgcgtgcgtg tgtgtgtgcg tggggagcgc cgcgtgcggc      180

tccgcgctgc ccggcggctg tgagcgctgc gggcgcggcg cggggctttg tgcgctccgc      240

agtgtgcgcg aggggagcgc ggccgggggc ggtgccccgc ggtgcggggg gggctgcgag      300

gggaacaaag gctgcgtgcg gggtgtgtgc gtgggggggt gagcaggggg tgtgggcgcg      360

tcggtcgggc tgcaaccccc cctgcacccc cctccccgag ttgctgagca cggcccggct      420

tcgggtgcgg ggctccgtac ggggcgtggc gcggggctcg ccgtgccggg cggggggtgg      480

cggcaggtgg gggtgccggg cggggcgggg ccgcctcggg ccggggaggg ctcgggggag      540

gggcgcggcg gcccccggag cgccggcggc tgtcgaggcg cggcgagccg cagccattgc      600

cttttatggt aatcgtgcga gagggcgcag ggacttcctt tgtcccaaat ctgtgcggag      660

ccgaaatctg ggaggcgccg ccgcaccccc tctagcgggc gcggggcgaa gcggtgcggc      720

gccggcagga aggaaatggg cggggagggc cttcgtgcgt cgccgcgccg ccgtcccctt      780

ctccctctcc agcctcgggg ctgtccgcgg ggggacggct gccttcgggg gggacggggc      840

agggcggggt tcggcttctg gcgtgtgacc ggcggctcta gagcctctgc taaccatgtt      900

catgccttct tctttttcct acagctcctg ggcaacgtgc tggttattgt gctgtctcat      960

cattttggca aag                                                         973


<210>  11
<211>  131
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  constructed sequence

<400>  11
ctggaggctt gctgaaggct gtatgctgtc gagttccttg atgtagttcg ttttggccac       60

tgactgacga actacaaagg aactcgacag gacacaaggc ctgttactag cactcacatg      120

gaacaaatgg c                                                           131


<210>  12
<211>  131
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  constructed sequence

<400>  12
ctggaggctt gctgaaggct gtatgctgcg atcgagttcc ttgatgtagg ttttggccac       60

tgactgacct acatcagaac tcgatcgcag gacacaaggc ctgttactag cactcacatg      120

gaacaaatgg c                                                           131


<210>  13
<211>  589
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  constructed sequence

<400>  13
aatcaacctc tggattacaa aatttgtgaa agattgactg gtattcttaa ctatgttgct       60

ccttttacgc tatgtggata cgctgcttta atgcctttgt atcatgctat tgcttcccgt      120

atggctttca ttttctcctc cttgtataaa tcctggttgc tgtctcttta tgaggagttg      180

tggcccgttg tcaggcaacg tggcgtggtg tgcactgtgt ttgctgacgc aacccccact      240

ggttggggca ttgccaccac ctgtcagctc ctttccggga ctttcgcttt ccccctccct      300

attgccacgg cggaactcat cgccgcctgc cttgcccgct gctggacagg ggctcggctg      360

ttgggcactg acaattccgt ggtgttgtcg gggaaatcat cgtcctttcc ttggctgctc      420

gcctgtgttg ccacctggat tctgcgcggg acgcccttct gctacgtccc ttcggccctc      480

aatccagcgg accttccttc ccgcggcctg ctgccggctc tgcggcctct tccgcgtctt      540

cgccttcgcc ctcagacgag tcggatctcc ctttgggccg cctccccgc                  589


<210>  14
<211>  130
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  constructed sequence

<400>  14
aggaacccct agtgatggag ttggccactc cctctctgcg cgctcgctcg ctcactgagg       60

ccgggcgacc aaaggtcgcc cgacgcccgg gctttgcccg ggcggcctca gtgagcgagc      120

gagcgcgcag                                                             130


<210>  15
<211>  460
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  hSynapsin promoter

<400>  15
tcgagctgca gagggccctg cgtatgagtg caagtgggtt ttaggaccag gatgaggcgg       60

ggtgggggtg cctacctgac gaccgacccc gacccactgg acaagcaccc aacccccatt      120

ccccaaattg cgcatcccct atcagagagg gggaggggaa acaggatgcg gcgaggcgcg      180

tgcgcactgc cagcttcagc accgcggaca gtgccttcgc ccccgcctgg cggcgcgcgc      240

caccgccgcc tcagcactga aggcgcgctg acgtcactcg ccggtccccc gcaaactccc      300

cttcccggcc accttggtcg cgtccgcgcc gccgccggcc cagccggacc gcaccacgcg      360

aggcgcgaga taggggggca cgggcgcgac catctgcgct gcggcgccgg cgactcagcg      420

ctgcctcagt ctgcggtggg cagcggagga gtcgtgtcgt                            460


<210>  16
<211>  8030
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  production plasmid pAAV2hu68n.KanR


<220>
<221>  promoter
<222>  (1)..(36)
<223>  Truncated P5

<220>
<221>  misc_feature
<222>  (37)..(1899)
<223>  AAV2 Rep

<220>
<221>  CDS
<222>  (1919)..(4129)
<223>  AAVhu68 Cap

<220>
<221>  promoter
<222>  (4220)..(4350)
<223>  P5 promoter

<220>
<221>  promoter
<222>  (4398)..(4692)
<223>  LacZ promoter

<220>
<221>  misc_feature
<222>  (4875)..(5463)
<223>  Col E1 ori

<220>
<221>  misc_feature
<222>  (6160)..(6975)
<223>  KanR

<220>
<221>  misc_feature
<222>  (7195)..(7229)
<223>  KanR

<220>
<221>  misc_feature
<222>  (7325)..(7780)
<223>  f1 ori

<400>  16
ccattttgaa gcgggaggtt tgaacgcgca gccgccatgc cggggtttta cgagattgtg       60

attaaggtcc ccagcgacct tgacgagcat ctgcccggca tttctgacag ctttgtgaac      120

tgggtggccg agaaggaatg ggagttgccg ccagattctg acatggatct gaatctgatt      180

gagcaggcac ccctgaccgt ggccgagaag ctgcagcgcg actttctgac ggaatggcgc      240

cgtgtgagta aggccccgga ggctcttttc tttgtgcaat ttgagaaggg agagagctac      300

ttccacatgc acgtgctcgt ggaaaccacc ggggtgaaat ccatggtttt gggacgtttc      360

ctgagtcaga ttcgcgaaaa actgattcag agaatttacc gcgggatcga gccgactttg      420

ccaaactggt tcgcggtcac aaagaccaga aatggcgccg gaggcgggaa caaggtggtg      480

gatgagtgct acatccccaa ttacttgctc cccaaaaccc agcctgagct ccagtgggcg      540

tggactaata tggaacagta tttaagcgcc tgtttgaatc tcacggagcg taaacggttg      600

gtggcgcagc atctgacgca cgtgtcgcag acgcaggagc agaacaaaga gaatcagaat      660

cccaattctg atgcgccggt gatcagatca aaaacttcag ccaggtacat ggagctggtc      720

gggtggctcg tggacaaggg gattacctcg gagaagcagt ggatccagga ggaccaggcc      780

tcatacatct ccttcaatgc ggcctccaac tcgcggtccc aaatcaaggc tgccttggac      840

aatgcgggaa agattatgag cctgactaaa accgcccccg actacctggt gggccagcag      900

cccgtggagg acatttccag caatcggatt tataaaattt tggaactaaa cgggtacgat      960

ccccaatatg cggcttccgt ctttctggga tgggccacga aaaagttcgg caagaggaac     1020

accatctggc tgtttgggcc tgcaactacc gggaagacca acatcgcgga ggccatagcc     1080

cacactgtgc ccttctacgg gtgcgtaaac tggaccaatg agaactttcc cttcaacgac     1140

tgtgtcgaca agatggtgat ctggtgggag gaggggaaga tgaccgccaa ggtcgtggag     1200

tcggccaaag ccattctcgg aggaagcaag gtgcgcgtgg accagaaatg caagtcctcg     1260

gcccagatag acccgactcc cgtgatcgtc acctccaaca ccaacatgtg cgccgtgatt     1320

gacgggaact caacgacctt cgaacaccag cagccgttgc aagaccggat gttcaaattt     1380

gaactcaccc gccgtctgga tcatgacttt gggaaggtca ccaagcagga agtcaaagac     1440

tttttccggt gggcaaagga tcacgtggtt gaggtggagc atgaattcta cgtcaaaaag     1500

ggtggagcca agaaaagacc cgcccccagt gacgcagata taagtgagcc caaacgggtg     1560

cgcgagtcag ttgcgcagcc atcgacgtca gacgcggaag cttcgatcaa ctacgcagac     1620

aggtaccaaa acaaatgttc tcgtcacgtg ggcatgaatc tgatgctgtt tccctgcaga     1680

caatgcgaga gaatgaatca gaattcaaat atctgcttca ctcacggaca gaaagactgt     1740

ttagagtgct ttcccgtgtc agaatctcaa cccgtttctg tcgtcaaaaa ggcgtatcag     1800

aaactgtgct acattcatca tatcatggga aaggtgccag acgcttgcac tgcctgcgat     1860

ctggtcaatg tggatttgga tgactgcatc tttgaacaat aaatgattta aatcaggt       1918

atg gct gcc gat ggt tat ctt cca gat tgg ctc gag gac aac ctc agt       1966
Met Ala Ala Asp Gly Tyr Leu Pro Asp Trp Leu Glu Asp Asn Leu Ser           
1               5                   10                  15                

gaa ggc att cgc gag tgg tgg gct ttg aaa cct gga gcc cct caa ccc       2014
Glu Gly Ile Arg Glu Trp Trp Ala Leu Lys Pro Gly Ala Pro Gln Pro           
            20                  25                  30                    

aag gca aat caa caa cat caa gac aac gct cgg ggt ctt gtg ctt ccg       2062
Lys Ala Asn Gln Gln His Gln Asp Asn Ala Arg Gly Leu Val Leu Pro           
        35                  40                  45                        

ggt tac aaa tac ctt gga ccc ggc aac gga ctc gac aag ggg gag ccg       2110
Gly Tyr Lys Tyr Leu Gly Pro Gly Asn Gly Leu Asp Lys Gly Glu Pro           
    50                  55                  60                            

gtc aac gaa gca gac gcg gcg gcc ctc gag cac gac aag gcc tac gac       2158
Val Asn Glu Ala Asp Ala Ala Ala Leu Glu His Asp Lys Ala Tyr Asp           
65                  70                  75                  80            

cag cag ctc aag gcc gga gac aac ccg tac ctc aag tac aac cac gcc       2206
Gln Gln Leu Lys Ala Gly Asp Asn Pro Tyr Leu Lys Tyr Asn His Ala           
                85                  90                  95                

gac gcc gag ttc cag gag cgg ctc aaa gaa gat acg tct ttt ggg ggc       2254
Asp Ala Glu Phe Gln Glu Arg Leu Lys Glu Asp Thr Ser Phe Gly Gly           
            100                 105                 110                   

aac ctc ggg cga gca gtc ttc cag gcc aaa aag agg ctt ctt gaa cct       2302
Asn Leu Gly Arg Ala Val Phe Gln Ala Lys Lys Arg Leu Leu Glu Pro           
        115                 120                 125                       

ctt ggt ctg gtt gag gaa gcg gct aag acg gct cct gga aag aag agg       2350
Leu Gly Leu Val Glu Glu Ala Ala Lys Thr Ala Pro Gly Lys Lys Arg           
    130                 135                 140                           

cct gta gag cag tct cct cag gaa ccg gac tcc tcc gtg ggt att ggc       2398
Pro Val Glu Gln Ser Pro Gln Glu Pro Asp Ser Ser Val Gly Ile Gly           
145                 150                 155                 160           

aaa tcg ggt gca cag ccc gct aaa aag aga ctc aat ttc ggt cag act       2446
Lys Ser Gly Ala Gln Pro Ala Lys Lys Arg Leu Asn Phe Gly Gln Thr           
                165                 170                 175               

ggc gac aca gag tca gtc ccc gac cct caa cca atc gga gaa cct ccc       2494
Gly Asp Thr Glu Ser Val Pro Asp Pro Gln Pro Ile Gly Glu Pro Pro           
            180                 185                 190                   

gca gcc ccc tca ggt gtg gga tct ctt aca atg gct tca ggt ggt ggc       2542
Ala Ala Pro Ser Gly Val Gly Ser Leu Thr Met Ala Ser Gly Gly Gly           
        195                 200                 205                       

gca cca gtg gca gac aat aac gaa ggt gcc gat gga gtg ggt agt tcc       2590
Ala Pro Val Ala Asp Asn Asn Glu Gly Ala Asp Gly Val Gly Ser Ser           
    210                 215                 220                           

tcg gga aat tgg cat tgc gat tcc caa tgg ctg ggg gac aga gtc atc       2638
Ser Gly Asn Trp His Cys Asp Ser Gln Trp Leu Gly Asp Arg Val Ile           
225                 230                 235                 240           

acc acc agc acc cga acc tgg gcc ctg ccc acc tac aac aat cac ctc       2686
Thr Thr Ser Thr Arg Thr Trp Ala Leu Pro Thr Tyr Asn Asn His Leu           
                245                 250                 255               

tac aag caa atc tcc aac agc aca tct gga gga tct tca aat gac aac       2734
Tyr Lys Gln Ile Ser Asn Ser Thr Ser Gly Gly Ser Ser Asn Asp Asn           
            260                 265                 270                   

gcc tac ttc ggc tac agc acc ccc tgg ggg tat ttt gac ttc aac aga       2782
Ala Tyr Phe Gly Tyr Ser Thr Pro Trp Gly Tyr Phe Asp Phe Asn Arg           
        275                 280                 285                       

ttc cac tgc cac ttc tca cca cgt gac tgg caa aga ctc atc aac aac       2830
Phe His Cys His Phe Ser Pro Arg Asp Trp Gln Arg Leu Ile Asn Asn           
    290                 295                 300                           

aac tgg gga ttc cgg cct aag cga ctc aac ttc aag ctc ttc aac att       2878
Asn Trp Gly Phe Arg Pro Lys Arg Leu Asn Phe Lys Leu Phe Asn Ile           
305                 310                 315                 320           

cag gtc aaa gag gtt acg gac aac aat gga gtc aag acc atc gct aat       2926
Gln Val Lys Glu Val Thr Asp Asn Asn Gly Val Lys Thr Ile Ala Asn           
                325                 330                 335               

aac ctt acc agc acg gtc cag gtc ttc acg gac tca gac tat cag ctc       2974
Asn Leu Thr Ser Thr Val Gln Val Phe Thr Asp Ser Asp Tyr Gln Leu           
            340                 345                 350                   

ccg tac gtg ctc ggg tcg gct cac gag ggc tgc ctc ccg ccg ttc cca       3022
Pro Tyr Val Leu Gly Ser Ala His Glu Gly Cys Leu Pro Pro Phe Pro           
        355                 360                 365                       

gcg gac gtt ttc atg att cct cag tac ggg tat cta acg ctt aat gat       3070
Ala Asp Val Phe Met Ile Pro Gln Tyr Gly Tyr Leu Thr Leu Asn Asp           
    370                 375                 380                           

gga agc caa gcc gtg ggt cgt tcg tcc ttt tac tgc ctg gaa tat ttc       3118
Gly Ser Gln Ala Val Gly Arg Ser Ser Phe Tyr Cys Leu Glu Tyr Phe           
385                 390                 395                 400           

ccg tcg caa atg cta aga acg ggt aac aac ttc cag ttc agc tac gag       3166
Pro Ser Gln Met Leu Arg Thr Gly Asn Asn Phe Gln Phe Ser Tyr Glu           
                405                 410                 415               

ttt gag aac gta cct ttc cat agc agc tat gct cac agc caa agc ctg       3214
Phe Glu Asn Val Pro Phe His Ser Ser Tyr Ala His Ser Gln Ser Leu           
            420                 425                 430                   

gac cga ctc atg aat cca ctc atc gac caa tac ttg tac tat ctc tca       3262
Asp Arg Leu Met Asn Pro Leu Ile Asp Gln Tyr Leu Tyr Tyr Leu Ser           
        435                 440                 445                       

aag act att aac ggt tct gga cag aat caa caa acg cta aaa ttc agt       3310
Lys Thr Ile Asn Gly Ser Gly Gln Asn Gln Gln Thr Leu Lys Phe Ser           
    450                 455                 460                           

gtg gcc gga ccc agc aac atg gct gtc cag gga aga aac tac ata cct       3358
Val Ala Gly Pro Ser Asn Met Ala Val Gln Gly Arg Asn Tyr Ile Pro           
465                 470                 475                 480           

gga ccc agc tac cga caa caa cgt gtc tca acc act gtg act caa aac       3406
Gly Pro Ser Tyr Arg Gln Gln Arg Val Ser Thr Thr Val Thr Gln Asn           
                485                 490                 495               

aac aac agc gaa ttt gct tgg cct gga gct tct tct tgg gct ctc aat       3454
Asn Asn Ser Glu Phe Ala Trp Pro Gly Ala Ser Ser Trp Ala Leu Asn           
            500                 505                 510                   

gga cgt aat agc ttg atg aat cct gga cct gct atg gcc agc cac aaa       3502
Gly Arg Asn Ser Leu Met Asn Pro Gly Pro Ala Met Ala Ser His Lys           
        515                 520                 525                       

gaa gga gag gac cgt ttc ttt cct ttg tct gga tct tta att ttt ggc       3550
Glu Gly Glu Asp Arg Phe Phe Pro Leu Ser Gly Ser Leu Ile Phe Gly           
    530                 535                 540                           

aaa caa gga act gga aga gac aac gtg gat gcg gac aaa gtc atg ata       3598
Lys Gln Gly Thr Gly Arg Asp Asn Val Asp Ala Asp Lys Val Met Ile           
545                 550                 555                 560           

acc aac gaa gaa gaa att aaa act acc aac cca gta gca acg gag tcc       3646
Thr Asn Glu Glu Glu Ile Lys Thr Thr Asn Pro Val Ala Thr Glu Ser           
                565                 570                 575               

tat gga caa gtg gcc aca aac cac cag agt gcc caa gca cag gcg cag       3694
Tyr Gly Gln Val Ala Thr Asn His Gln Ser Ala Gln Ala Gln Ala Gln           
            580                 585                 590                   

acc ggc tgg gtt caa aac caa gga ata ctt ccg ggt atg gtt tgg cag       3742
Thr Gly Trp Val Gln Asn Gln Gly Ile Leu Pro Gly Met Val Trp Gln           
        595                 600                 605                       

gac aga gat gtg tac ctg caa gga ccc att tgg gcc aaa att cct cac       3790
Asp Arg Asp Val Tyr Leu Gln Gly Pro Ile Trp Ala Lys Ile Pro His           
    610                 615                 620                           

acg gac ggc aac ttt cac cct tct ccg ctg atg gga ggg ttt gga atg       3838
Thr Asp Gly Asn Phe His Pro Ser Pro Leu Met Gly Gly Phe Gly Met           
625                 630                 635                 640           

aag cac ccg cct cct cag atc ctc atc aaa aac aca cct gta cct gcg       3886
Lys His Pro Pro Pro Gln Ile Leu Ile Lys Asn Thr Pro Val Pro Ala           
                645                 650                 655               

gat cct cca acg gct ttc aac aag gac aag ctg aac tct ttc atc acc       3934
Asp Pro Pro Thr Ala Phe Asn Lys Asp Lys Leu Asn Ser Phe Ile Thr           
            660                 665                 670                   

cag tat tct act ggc caa gtc agc gtg gag att gag tgg gag ctg cag       3982
Gln Tyr Ser Thr Gly Gln Val Ser Val Glu Ile Glu Trp Glu Leu Gln           
        675                 680                 685                       

aag gaa aac agc aag cgc tgg aac ccg gag atc cag tac act tcc aac       4030
Lys Glu Asn Ser Lys Arg Trp Asn Pro Glu Ile Gln Tyr Thr Ser Asn           
    690                 695                 700                           

tat tac aag tct aat aat gtt gaa ttt gct gtt aat act gaa ggt gtt       4078
Tyr Tyr Lys Ser Asn Asn Val Glu Phe Ala Val Asn Thr Glu Gly Val           
705                 710                 715                 720           

tat tct gaa ccc cgc ccc att ggc acc aga tac ctg act cgt aat ctg       4126
Tyr Ser Glu Pro Arg Pro Ile Gly Thr Arg Tyr Leu Thr Arg Asn Leu           
                725                 730                 735               

taa ttgcttgtta atcaataaac cgtttaattc gtttcagttg aactttggtc            4179

tctgcgaagg gcgaattcgt ttaaacctgc aggactagag gtcctgtatt agaggtcacg     4239

tgagtgtttt gcgacatttt gcgacaccat gtggtcacgc tgggtattta agcccgagtg     4299

agcacgcagg gtctccattt tgaagcggga ggtttgaacg cgcagccgcc aagccgaatt     4359

ctgcagatat ccatcacact ggcggccgct cgactagagc ggccgccacc gcggtggagc     4419

tccagctttt gttcccttta gtgagggtta attgcgcgct tggcgtaatc atggtcatag     4479

ctgtttcctg tgtgaaattg ttatccgctc acaattccac acaacatacg agccggaagc     4539

ataaagtgta aagcctgggg tgcctaatga gtgagctaac tcacattaat tgcgttgcgc     4599

tcactgcccg ctttccagtc gggaaacctg tcgtgccagc tgcattaatg aatcggccaa     4659

cgcgcgggga gaggcggttt gcgtattggg cgctcttccg cttcctcgct cactgactcg     4719

ctgcgctcgg tcgttcggct gcggcgagcg gtatcagctc actcaaaggc ggtaatacgg     4779

ttatccacag aatcagggga taacgcagga aagaacatgt gagcaaaagg ccagcaaaag     4839

gccaggaacc gtaaaaaggc cgcgttgctg gcgtttttcc ataggctccg cccccctgac     4899

gagcatcaca aaaatcgacg ctcaagtcag aggtggcgaa acccgacagg actataaaga     4959

taccaggcgt ttccccctgg aagctccctc gtgcgctctc ctgttccgac cctgccgctt     5019

accggatacc tgtccgcctt tctcccttcg ggaagcgtgg cgctttctca tagctcacgc     5079

tgtaggtatc tcagttcggt gtaggtcgtt cgctccaagc tgggctgtgt gcacgaaccc     5139

cccgttcagc ccgaccgctg cgccttatcc ggtaactatc gtcttgagtc caacccggta     5199

agacacgact tatcgccact ggcagcagcc actggtaaca ggattagcag agcgaggtat     5259

gtaggcggtg ctacagagtt cttgaagtgg tggcctaact acggctacac tagaagaaca     5319

gtatttggta tctgcgctct gctgaagcca gttaccttcg gaaaaagagt tggtagctct     5379

tgatccggca aacaaaccac cgctggtagc ggtggttttt ttgtttgcaa gcagcagatt     5439

acgcgcagaa aaaaaggatc tcaagaagat cctttgatct tttctacggg gtctgacgct     5499

cagtggaacg aaaactcacg ttaagggatt ttggtcatga gattatcaaa aaggatcttc     5559

acctagatcc ttttgatcct ccggcgttca gcctgtgcca cagccgacag gatggtgacc     5619

accatttgcc ccatatcacc gtcggtactg atcccgtcgt caataaaccg aaccgctaca     5679

ccctgagcat caaactcttt tatcagttgg atcatgtcgg cggtgtcgcg gccaagacgg     5739

tcgagcttct tcaccagaat gacatcacct tcctccacct tcatcctcag caaatccagc     5799

ccttcccgat ctgttgaact gccggatgcc ttgtcggtaa agatgcggtt agcttttacc     5859

cctgcatctt tgagcgctga ggtctgcctc gtgaagaagg tgttgctgac tcataccagg     5919

cctgaatcgc cccatcatcc agccagaaag tgagggagcc acggttgatg agagctttgt     5979

tgtaggtgga ccagttggtg attttgaact tttgctttgc cacggaacgg tctgcgttgt     6039

cgggaagatg cgtgatctga tccttcaact cagcaaaagt tcgatttatt caacaaagcc     6099

gccgtcccgt caagtcagcg taatgctctg ccagtgttac aaccaattaa ccaattctga     6159

ttagaaaaac tcatcgagca tcaaatgaaa ctgcaattta ttcatatcag gattatcaat     6219

accatatttt tgaaaaagcc gtttctgtaa tgaaggagaa aactcaccga ggcagttcca     6279

taggatggca agatcctggt atcggtctgc gattccgact cgtccaacat caatacaacc     6339

tattaatttc ccctcgtcaa aaataaggtt atcaagtgag aaatcaccat gagtgacgac     6399

tgaatccggt gagaatggca aaagcttatg catttctttc cagacttgtt caacaggcca     6459

gccattacgc tcgtcatcaa aatcactcgc atcaaccaaa ccgttattca ttcgtgattg     6519

cgcctgagcg agacgaaata cgcgatcgct gttaaaagga caattacaaa caggaatcga     6579

atgcaaccgg cgcaggaaca ctgccagcgc atcaacaata ttttcacctg aatcaggata     6639

ttcttctaat acctggaatg ctgttttccc ggggatcgca gtggtgagta accatgcatc     6699

atcaggagta cggataaaat gcttgatggt cggaagaggc ataaattccg tcagccagtt     6759

tagtctgacc atctcatctg taacatcatt ggcaacgcta cctttgccat gtttcagaaa     6819

caactctggc gcatcgggct tcccatacaa tcgatagatt gtcgcacctg attgcccgac     6879

attatcgcga gcccatttat acccatataa atcagcatcc atgttggaat ttaatcgcgg     6939

cctcgagcaa gacgtttccc gttgaatatg gctcataaca ccccttgtat tactgtttat     6999

gtaagcagac agttttattg ttcatgatga tatattttta tcttgtgcaa tgtaacatca     7059

gagattttga gacactgcac ccaactgatc ttcagcatct tttactttca ccagcgtttc     7119

tgggtgagca aaaacaggaa ggcaaaatgc cgcaaaaaag ggaataaggg cgacacggaa     7179

atgttgaata ctcatactct tcctttttca atattattga agcatttatc agggttattg     7239

tctcatgagc ggatacatat ttgaatgtat ttagaaaaat aaacaaatag gggttccgcg     7299

cacatttccc cgaaaagtgc cacctaaatt gtaagcgtta atattttgtt aaaattcgcg     7359

ttaaattttt gttaaatcag ctcatttttt aaccaatagg ccgaaatcgg caaaatccct     7419

tataaatcaa aagaatagac cgagataggg ttgagtgttg ttccagtttg gaacaagagt     7479

ccactattaa agaacgtgga ctccaacgtc aaagggcgaa aaaccgtcta tcagggcgat     7539

ggcccactac gtgaaccatc accctaatca agttttttgg ggtcgaggtg ccgtaaagca     7599

ctaaatcgga accctaaagg gagcccccga tttagagctt gacggggaaa gccggcgaac     7659

gtggcgagaa aggaagggaa gaaagcgaaa ggagcgggcg ctagggcgct ggcaagtgta     7719

gcggtcacgc tgcgcgtaac caccacaccc gccgcgctta atgcgccgct acagggcgcg     7779

tcccattcgc cattcaggct gcgcaactgt tgggaagggc gatcggtgcg ggcctcttcg     7839

ctattacgcc agctggcgaa agggggatgt gctgcaaggc gattaagttg ggtaacgcca     7899

gggttttccc agtcacgacg ttgtaaaacg acggccagtg agcgcgcgta atacgactca     7959

ctatagggcg aattgggtac cgggcccccc ctcgatcgag gtcgacggta tcgggggagc     8019

tcgcagggtc t                                                          8030


<210>  17
<211>  736
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic Construct

<400>  17

Met Ala Ala Asp Gly Tyr Leu Pro Asp Trp Leu Glu Asp Asn Leu Ser 
1               5                   10                  15      


Glu Gly Ile Arg Glu Trp Trp Ala Leu Lys Pro Gly Ala Pro Gln Pro 
            20                  25                  30          


Lys Ala Asn Gln Gln His Gln Asp Asn Ala Arg Gly Leu Val Leu Pro 
        35                  40                  45              


Gly Tyr Lys Tyr Leu Gly Pro Gly Asn Gly Leu Asp Lys Gly Glu Pro 
    50                  55                  60                  


Val Asn Glu Ala Asp Ala Ala Ala Leu Glu His Asp Lys Ala Tyr Asp 
65                  70                  75                  80  


Gln Gln Leu Lys Ala Gly Asp Asn Pro Tyr Leu Lys Tyr Asn His Ala 
                85                  90                  95      


Asp Ala Glu Phe Gln Glu Arg Leu Lys Glu Asp Thr Ser Phe Gly Gly 
            100                 105                 110         


Asn Leu Gly Arg Ala Val Phe Gln Ala Lys Lys Arg Leu Leu Glu Pro 
        115                 120                 125             


Leu Gly Leu Val Glu Glu Ala Ala Lys Thr Ala Pro Gly Lys Lys Arg 
    130                 135                 140                 


Pro Val Glu Gln Ser Pro Gln Glu Pro Asp Ser Ser Val Gly Ile Gly 
145                 150                 155                 160 


Lys Ser Gly Ala Gln Pro Ala Lys Lys Arg Leu Asn Phe Gly Gln Thr 
                165                 170                 175     


Gly Asp Thr Glu Ser Val Pro Asp Pro Gln Pro Ile Gly Glu Pro Pro 
            180                 185                 190         


Ala Ala Pro Ser Gly Val Gly Ser Leu Thr Met Ala Ser Gly Gly Gly 
        195                 200                 205             


Ala Pro Val Ala Asp Asn Asn Glu Gly Ala Asp Gly Val Gly Ser Ser 
    210                 215                 220                 


Ser Gly Asn Trp His Cys Asp Ser Gln Trp Leu Gly Asp Arg Val Ile 
225                 230                 235                 240 


Thr Thr Ser Thr Arg Thr Trp Ala Leu Pro Thr Tyr Asn Asn His Leu 
                245                 250                 255     


Tyr Lys Gln Ile Ser Asn Ser Thr Ser Gly Gly Ser Ser Asn Asp Asn 
            260                 265                 270         


Ala Tyr Phe Gly Tyr Ser Thr Pro Trp Gly Tyr Phe Asp Phe Asn Arg 
        275                 280                 285             


Phe His Cys His Phe Ser Pro Arg Asp Trp Gln Arg Leu Ile Asn Asn 
    290                 295                 300                 


Asn Trp Gly Phe Arg Pro Lys Arg Leu Asn Phe Lys Leu Phe Asn Ile 
305                 310                 315                 320 


Gln Val Lys Glu Val Thr Asp Asn Asn Gly Val Lys Thr Ile Ala Asn 
                325                 330                 335     


Asn Leu Thr Ser Thr Val Gln Val Phe Thr Asp Ser Asp Tyr Gln Leu 
            340                 345                 350         


Pro Tyr Val Leu Gly Ser Ala His Glu Gly Cys Leu Pro Pro Phe Pro 
        355                 360                 365             


Ala Asp Val Phe Met Ile Pro Gln Tyr Gly Tyr Leu Thr Leu Asn Asp 
    370                 375                 380                 


Gly Ser Gln Ala Val Gly Arg Ser Ser Phe Tyr Cys Leu Glu Tyr Phe 
385                 390                 395                 400 


Pro Ser Gln Met Leu Arg Thr Gly Asn Asn Phe Gln Phe Ser Tyr Glu 
                405                 410                 415     


Phe Glu Asn Val Pro Phe His Ser Ser Tyr Ala His Ser Gln Ser Leu 
            420                 425                 430         


Asp Arg Leu Met Asn Pro Leu Ile Asp Gln Tyr Leu Tyr Tyr Leu Ser 
        435                 440                 445             


Lys Thr Ile Asn Gly Ser Gly Gln Asn Gln Gln Thr Leu Lys Phe Ser 
    450                 455                 460                 


Val Ala Gly Pro Ser Asn Met Ala Val Gln Gly Arg Asn Tyr Ile Pro 
465                 470                 475                 480 


Gly Pro Ser Tyr Arg Gln Gln Arg Val Ser Thr Thr Val Thr Gln Asn 
                485                 490                 495     


Asn Asn Ser Glu Phe Ala Trp Pro Gly Ala Ser Ser Trp Ala Leu Asn 
            500                 505                 510         


Gly Arg Asn Ser Leu Met Asn Pro Gly Pro Ala Met Ala Ser His Lys 
        515                 520                 525             


Glu Gly Glu Asp Arg Phe Phe Pro Leu Ser Gly Ser Leu Ile Phe Gly 
    530                 535                 540                 


Lys Gln Gly Thr Gly Arg Asp Asn Val Asp Ala Asp Lys Val Met Ile 
545                 550                 555                 560 


Thr Asn Glu Glu Glu Ile Lys Thr Thr Asn Pro Val Ala Thr Glu Ser 
                565                 570                 575     


Tyr Gly Gln Val Ala Thr Asn His Gln Ser Ala Gln Ala Gln Ala Gln 
            580                 585                 590         


Thr Gly Trp Val Gln Asn Gln Gly Ile Leu Pro Gly Met Val Trp Gln 
        595                 600                 605             


Asp Arg Asp Val Tyr Leu Gln Gly Pro Ile Trp Ala Lys Ile Pro His 
    610                 615                 620                 


Thr Asp Gly Asn Phe His Pro Ser Pro Leu Met Gly Gly Phe Gly Met 
625                 630                 635                 640 


Lys His Pro Pro Pro Gln Ile Leu Ile Lys Asn Thr Pro Val Pro Ala 
                645                 650                 655     


Asp Pro Pro Thr Ala Phe Asn Lys Asp Lys Leu Asn Ser Phe Ile Thr 
            660                 665                 670         


Gln Tyr Ser Thr Gly Gln Val Ser Val Glu Ile Glu Trp Glu Leu Gln 
        675                 680                 685             


Lys Glu Asn Ser Lys Arg Trp Asn Pro Glu Ile Gln Tyr Thr Ser Asn 
    690                 695                 700                 


Tyr Tyr Lys Ser Asn Asn Val Glu Phe Ala Val Asn Thr Glu Gly Val 
705                 710                 715                 720 


Tyr Ser Glu Pro Arg Pro Ile Gly Thr Arg Tyr Leu Thr Arg Asn Leu 
                725                 730                 735     


<210>  18
<211>  2211
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  hu68

<400>  18
atggctgccg atggttatct tccagattgg ctcgaggaca acctcagtga aggcattcgc       60

gagtggtggg ctttgaaacc tggagcccct caacccaagg caaatcaaca acatcaagac      120

aacgctcggg gtcttgtgct tccgggttac aaataccttg gacccggcaa cggactcgac      180

aagggggagc cggtcaacga agcagacgcg gcggccctcg agcacgacaa ggcctacgac      240

cagcagctca aggccggaga caacccgtac ctcaagtaca accacgccga cgccgagttc      300

caggagcggc tcaaagaaga tacgtctttt gggggcaacc tcgggcgagc agtcttccag      360

gccaaaaaga ggcttcttga acctcttggt ctggttgagg aagcggctaa gacggctcct      420

ggaaagaaga ggcctgtaga gcagtctcct caggaaccgg actcctccgt gggtattggc      480

aaatcgggtg cacagcccgc taaaaagaga ctcaatttcg gtcagactgg cgacacagag      540

tcagtccccg accctcaacc aatcggagaa cctcccgcag ccccctcagg tgtgggatct      600

cttacaatgg cttcaggtgg tggcgcacca gtggcagaca ataacgaagg tgccgatgga      660

gtgggtagtt cctcgggaaa ttggcattgc gattcccaat ggctggggga cagagtcatc      720

accaccagca cccgaacctg ggccctgccc acctacaaca atcacctcta caagcaaatc      780

tccaacagca catctggagg atcttcaaat gacaacgcct acttcggcta cagcaccccc      840

tgggggtatt ttgacttcaa cagattccac tgccacttct caccacgtga ctggcaaaga      900

ctcatcaaca acaactgggg attccggcct aagcgactca acttcaagct cttcaacatt      960

caggtcaaag aggttacgga caacaatgga gtcaagacca tcgctaataa ccttaccagc     1020

acggtccagg tcttcacgga ctcagactat cagctcccgt acgtgctcgg gtcggctcac     1080

gagggctgcc tcccgccgtt cccagcggac gttttcatga ttcctcagta cgggtatcta     1140

acgcttaatg atggaagcca agccgtgggt cgttcgtcct tttactgcct ggaatatttc     1200

ccgtcgcaaa tgctaagaac gggtaacaac ttccagttca gctacgagtt tgagaacgta     1260

cctttccata gcagctatgc tcacagccaa agcctggacc gactcatgaa tccactcatc     1320

gaccaatact tgtactatct ctcaaagact attaacggtt ctggacagaa tcaacaaacg     1380

ctaaaattca gtgtggccgg acccagcaac atggctgtcc agggaagaaa ctacatacct     1440

ggacccagct accgacaaca acgtgtctca accactgtga ctcaaaacaa caacagcgaa     1500

tttgcttggc ctggagcttc ttcttgggct ctcaatggac gtaatagctt gatgaatcct     1560

ggacctgcta tggccagcca caaagaagga gaggaccgtt tctttccttt gtctggatct     1620

ttaatttttg gcaaacaagg aactggaaga gacaacgtgg atgcggacaa agtcatgata     1680

accaacgaag aagaaattaa aactaccaac ccagtagcaa cggagtccta tggacaagtg     1740

gccacaaacc accagagtgc ccaagcacag gcgcagaccg gctgggttca aaaccaagga     1800

atacttccgg gtatggtttg gcaggacaga gatgtgtacc tgcaaggacc catttgggcc     1860

aaaattcctc acacggacgg caactttcac ccttctccgc tgatgggagg gtttggaatg     1920

aagcacccgc ctcctcagat cctcatcaaa aacacacctg tacctgcgga tcctccaacg     1980

gctttcaaca aggacaagct gaactctttc atcacccagt attctactgg ccaagtcagc     2040

gtggagattg agtgggagct gcagaaggaa aacagcaagc gctggaaccc ggagatccag     2100

tacacttcca actattacaa gtctaataat gttgaatttg ctgttaatac tgaaggtgtt     2160

tattctgaac cccgccccat tggcaccaga tacctgactc gtaatctgta a              2211


<210>  19
<211>  2211
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  hu68 M191

<400>  19
atggctgccg atggttatct tccagattgg ctcgaggaca acctcagtga aggcattcgc       60

gagtggtggg ctttgaaacc tggagcccct caacccaagg caaatcaaca acatcaagac      120

aacgctcggg gtcttgtgct tccgggttac aaataccttg gacccggcaa cggactcgac      180

aagggggagc cggtcaacga agcagacgcg gcggccctcg agcacgacaa ggcctacgac      240

cagcagctca aggccggaga caacccgtac ctcaagtaca accacgccga cgccgagttc      300

caggagcggc tcaaagaaga tacgtctttt gggggcaacc tcgggcgagc agtcttccag      360

gccaaaaaga ggcttcttga acctcttggt ctggttgagg aagcggctaa gacggctcct      420

ggaaagaaga ggcctgtaga gcagtctcct caggaaccgg actcctccgt gggtattggc      480

aaatcgggtg cacagcccgc taaaaagaga ctcaatttcg gtcagactgg cgacacagag      540

tcagtccccg accctcaacc aatcggagaa cctcccgcag ccccctcagg tgtgggatct      600

cttacaatgg cttcaggtgg tggcgcacca gtggcagaca ataacgaagg tgccgatgga      660

gtgggtagtt cctcgggaaa ttggcattgc gattcccaat ggctggggga cagagtcatc      720

accaccagca cccgaacctg ggccctgccc acctacaaca atcacctcta caagcaaatc      780

tccaacagca catctggagg atcttcaaat gacaacgcct acttcggcta cagcaccccc      840

tgggggtatt ttgacttcaa cagattccac tgccacttct caccacgtga ctggcaaaga      900

ctcatcaaca acaactgggg attccggcct aagcgactca acttcaagct cttcaacatt      960

caggtcaaag aggttacgga caacaatgga gtcaagacca tcgctaataa ccttaccagc     1020

acggtccagg tcttcacgga ctcagactat cagctcccgt acgtgctcgg gtcggctcac     1080

gagggctgcc tcccgccgtt cccagcggac gttttcatga ttcctcagta tggatacctc     1140

accctgaacg acggcagtca ggcggtgggc cgctcatcct tctactgcct ggagtacttc     1200

ccttcgcaga tgctgaggac tggcaacaac ttccagttca gctacgagtt cgagaacgtc     1260

cctttccaca gcagctacgc ccacagccag agtttggacc gcttgatgaa ccctctgatc     1320

gaccagtacc tgtactacct gtcaaagacg atcaacggtt ctggccagaa ccagcagacg     1380

ctgaagttca gcgtggccgg gcctagcaac atggccgtcc agggcagaaa ctacatccct     1440

gggcccagct accggcagca gagagtctca accactgtga ctcagaacaa caacagtgag     1500

ttcgcctggc ctggcgccag ctcttgggcc ctcaacggcc gcaactcgct gatgaaccca     1560

ggcccagcca tggccagtca caaggagggc gaggaccgtt tcttcccttt gtctggctct     1620

ctgatcttcg gcaagcaggg gaccggcaga gacaacgtgg acgcggacaa ggtcatgatc     1680

acgaacgagg aggagatcaa gaccaccaac cctgtggcaa ccgagtccta cggccaggtg     1740

gcaaccaacc accagagcgc ccaggcacag gcgcagactg gctgggtcca gaaccagggg     1800

atcctgcctg gcatggtgtg gcaggaccgt gacgtgtacc tgcagggccc tatctgggca     1860

aagatccctc acacggacgg caacttccac ccttctcctc tgatgggcgg cttcggcatg     1920

aagcacccgc ctcctcagat cctcatcaag aacactccgg tcccggcaga ccctccgacg     1980

gccttcaaca aggacaagct gaactcattc atcactcagt actccactgg ccaggtcagc     2040

gtggagatcg agtgggagct gcagaaggag aacagcaagc gttggaaccc agagatccag     2100

tacacttcca actactacaa gtctaacaac gtggagttcg ccgtcaacac tgagggtgtg     2160

tacagtgagc ctcgccctat cggcacccgg tacctcaccc gaaacttgtg a              2211


<210>  20
<211>  8543
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  production plasmid pAAV-PHP.eB


<220>
<221>  promoter
<222>  (140)..(158)
<223>  T7 promoter

<220>
<221>  misc_feature
<222>  (239)..(2104)
<223>  AAV2 Rep

<220>
<221>  misc_feature
<222>  (648)..(657)
<223>  p19 SRE

<220>
<221>  misc_feature
<222>  (663)..(683)
<223>  p19 SP1 and GGT

<220>
<221>  misc_feature
<222>  (737)..(745)
<223>  SP1 binding

<220>
<221>  misc_feature
<222>  (761)..(767)
<223>  p19 TATA

<220>
<221>  misc_feature
<222>  (1618)..(1772)
<223>  p40

<220>
<221>  misc_feature
<222>  (2121)..(2867)
<223>  rtTA2S-M2

<220>
<221>  misc_feature
<222>  (2748)..(2858)
<223>  VP48

<220>
<221>  misc_feature
<222>  (2897)..(2915)
<223>  SP6 promoter

<220>
<221>  polyA_signal
<222>  (2941)..(3165)
<223>  bGH poly(A) signal

<220>
<221>  protein_bind
<222>  (3264)..(3282)
<223>  tet operator

<220>
<221>  protein_bind
<222>  (3301)..(3319)
<223>  tet operator

<220>
<221>  protein_bind
<222>  (3338)..(3356)
<223>  tet operator

<220>
<221>  protein_bind
<222>  (3375)..(3393)
<223>  tet operator

<220>
<221>  protein_bind
<222>  (3412)..(3430)
<223>  tet operator

<220>
<221>  protein_bind
<222>  (3449)..(3467)
<223>  tet operator

<220>
<221>  protein_bind
<222>  (3486)..(3504)
<223>  tet operator

<220>
<221>  misc_feature
<222>  (3533)..(3825)
<223>  AAV5 rep22 sequence

<220>
<221>  misc_feature
<222>  (3826)..(3827)
<223>  AAV5 rep sequence

<220>
<221>  misc_feature
<222>  (3826)..(3827)
<223>  p41

<220>
<221>  misc_feature
<222>  (3828)..(4131)
<223>  AAV2 rep sequence

<220>
<221>  misc_feature
<222>  (3851)..(3852)
<223>  Splice donor

<220>
<221>  misc_feature
<222>  (4143)..(4146)
<223>  minor VP1 aceptor

<220>
<221>  CDS
<222>  (4148)..(6376)
<223>  AAVPHP.eB Cap

<220>
<221>  misc_feature
<222>  (4559)..(4561)
<223>  VP2

<220>
<221>  misc_feature
<222>  (4674)..(5264)
<223>  AAP

<220>
<221>  misc_feature
<222>  (4754)..(4756)
<223>  VP3 start

<220>
<221>  misc_feature
<222>  (5907)..(5911)
<223>  AAV-PHP.B

<220>
<221>  misc_feature
<222>  (5912)..(5932)
<223>  PHP.B

<220>
<221>  misc_feature
<222>  (6386)..(6441)
<223>  AAV2 sequence

<400>  20
ccaatgatac gcgtcggtgc gggcctcttc gctattacgc cagctggcga aagggggatg       60

tgctgcaagg cgattaagtt gggtaacgcc agggttttcc cagtcacgac gttgtaaaac      120

gacggccagt gagcgcgcgt aatacgactc actatagggc gaattgggta catcgacggt      180

atcgggggag ctcgcagggt ctccattttg aagcgggagg tttgaacgcg cagccgccat      240

gccggggttt tacgagattg tgattaaggt ccccagcgac cttgacgagc atctgcccgg      300

catttctgac agctttgtga actgggtggc cgagaaggaa tgggagttgc cgccagattc      360

tgacatggat ctgaatctga ttgagcaggc acccctgacc gtggccgaga agctgcagcg      420

cgactttctg acggaatggc gccgtgtgag taaggccccg gaggctcttt tctttgtgca      480

atttgagaag ggagagagct acttccacat gcacgtgctc gtggaaacca ccggggtgaa      540

atccatggtt ttgggacgtt tcctgagtca gattcgcgaa aaactgattc agagaattta      600

ccgcgggatc gagccgactt tgccaaactg gttcgcggtc acaaagacca gaaatggcgc      660

cggaggcggg aacaaggtgg tggatgagtg ctacatcccc aattacttgc tccccaaaac      720

ccagcctgag ctccagtggg cgtggactaa tatggaacag tatttaagcg cctgtttgaa      780

tctcacggag cgtaaacggt tggtggcgca gcatctgacg cacgtgtcgc agacgcagga      840

gcagaacaaa gagaatcaga atcccaattc tgatgcgccg gtgatcagat caaaaacttc      900

agccaggtac atggagctgg tcgggtggct cgtggacaag gggattacct cggagaagca      960

gtggatccag gaggaccagg cctcatacat ctccttcaat gcggcctcca actcgcggtc     1020

ccaaatcaag gctgccttgg acaatgcggg aaagattatg agcctgacta aaaccgcccc     1080

cgactacctg gtgggccagc agcccgtgga ggacatttcc agcaatcgga tttataaaat     1140

tttggaacta aacgggtacg atccccaata tgcggcttcc gtctttctgg gatgggccac     1200

gaaaaagttc ggcaagagga acaccatctg gctgtttggg cctgcaacta ccgggaagac     1260

caacatcgcg gaggccatag cccacactgt gcccttctac gggtgcgtaa actggaccaa     1320

tgagaacttt cccttcaacg actgtgtgga caagatggtg atctggtggg aggaggggaa     1380

gatgaccgcc aaggtcgtgg agtcggccaa agccattctc ggaggaagca aggtgcgcgt     1440

ggaccagaaa tgcaagtcct cggcccagat agacccgact cccgtgatcg tcacctccaa     1500

caccaatatg tgcgccgtga ttgacgggaa ctcaacgacc ttcgaacacc agcagccgtt     1560

gcaagaccgg atgttcaaat ttgaactcac ccgccgtctg gatcatgact ttgggaaggt     1620

caccaagcag gaagtcaaag actttttccg gtgggcaaag gatcacgtgg ttgaggtgga     1680

gcatgaattc tacgtcaaaa agggtggagc caagaaaaga cccgccccca gtgacgcaga     1740

tataagtgag cccaaacggg tgcgcgagtc agttgcgcag ccatcgacgt cagacgcgga     1800

agcttcgatc aactacgcgg acaggtacca aaacaaatgt tctcgtcacg tgggcatgaa     1860

tctgatgctg tttccctgca gacaatgcga gagactgaat cagaattcaa atatctgctt     1920

cactcacggt gtcaaagact gtttagagtg ctttcccgtg tcagaatctc aacccgtttc     1980

tgtcgtcaaa aaggcgtatc agaaactgtg ctacattcat cacatcatgg gaaaggtgcc     2040

agacgcttgc actgcttgcg acctggtcaa tgtggacttg gatgactgtg tttctgaaca     2100

ataaatgact taaaccaggt atgagtcggc tggataaatc taaagtcata aacggcgctc     2160

tggaattact caatgaagtc ggtatcgaag gcctgacgac aaggaaactc gctcaaaagc     2220

tgggagttga gcagcctacc ctgtactggc acgtgaagaa caagcgggcc ctgctcgatg     2280

ccctggccat cgagatgctg gacaggcatc atacccactt ctgccccctg gaaggcgagt     2340

catggcaaga ctttctgcgg aacaacgcca agtcattccg ctgtgctctc ctctcacatc     2400

gcgacggggc taaagtgcat ctcggcaccc gcccaacaga gaaacagtac gaaaccctgg     2460

aaaatcagct cgcgttcctg tgtcagcaag gcttctccct ggagaacgca ctgtacgctc     2520

tgtccgccgt gggccacttt acactgggct gcgtattgga ggaacaggag catcaagtag     2580

caaaagagga aagagagaca cctaccaccg attctatgcc cccacttctg agacaagcaa     2640

ttgagctgtt cgaccggcag ggagccgaac ctgccttcct tttcggcctg gaactaatca     2700

tatgtggcct ggagaaacag ctaaagtgcg aaagcggcgg gccggccgac gcccttgacg     2760

attttgactt agacatgctc ccagccgatg cccttgacga ctttgacctt gatatgctgc     2820

ctgctgacgc tcttgacgat tttgaccttg acatgctccc cgggtaaatg catgaattcg     2880

atctagaggg ccctattcta tagtgtcacc taaatgctag agctcgctga tcagcctcga     2940

ctgtgccttc tagttgccag ccatctgttg tttgcccctc ccccgtgcct tccttgaccc     3000

tggaaggtgc cactcccact gtcctttcct aataaaatga ggaaattgca tcgcattgtc     3060

tgagtaggtg tcattctatt ctggggggtg gggtggggca ggacagcaag ggggaggatt     3120

gggaagacaa tagcaggcat gctggggatg cggtgggctc tatggcttct gaggcggaaa     3180

gaaccagctg gggctcgaat caagctatca agtgccacct gacgtctccc tatcagtgat     3240

agagaagtcg acacgtctcg agctccctat cagtgataga gaaggtacgt ctagaacgtc     3300

tccctatcag tgatagagaa gtcgacacgt ctcgagctcc ctatcagtga tagagaaggt     3360

acgtctagaa cgtctcccta tcagtgatag agaagtcgac acgtctcgag ctccctatca     3420

gtgatagaga aggtacgtct agaacgtctc cctatcagtg atagagaagt cgacacgtct     3480

cgagctccct atcagtgata gagaaggtac cccctatata agcagagaga tctgttcaaa     3540

tttgaactga ctaagcggct cccgccagat tttggcaaga ttactaagca ggaagtcaag     3600

gacttttttg cttgggcaaa ggtcaatcag gtgccggtga ctcacgagtt taaagttccc     3660

agggaattgg cgggaactaa aggggcggag aaatctctaa aacgcccact gggtgacgtc     3720

accaatacta gctataaaag tctggagaag cgggccaggc tctcatttgt tcccgagacg     3780

cctcgcagtt cagacgtgac tgttgatccc gctcctctgc gaccgctagc ttcgatcaac     3840

tacgcagaca ggtaccaaaa caagtgttct cgtcacgtgg gcattaatct gattctgttt     3900

ccctgcagac aatgcgagag aatgaatcag aactcaaata tctgcttcac tcacggacag     3960

aaagactgtt tagagtgctt tcccgtgtca gaatctcaac ccgtttctgt cgtcaaaaag     4020

gcgtatcaga aactgtgcta cattcatcat atcatgggaa aggtgccaga cgcttgcact     4080

gcctgcgatc tggtcaatgt ggatttggat gactgcatct ttgaacaata aatgacttaa     4140

gccaggt atg gct gcc gat ggt tat ctt cca gat tgg ctc gag gac aac       4189
        Met Ala Ala Asp Gly Tyr Leu Pro Asp Trp Leu Glu Asp Asn           
        1               5                   10                            

ctt agt gaa gga att cgc gag tgg tgg gct ttg aaa cct gga gcc cct       4237
Leu Ser Glu Gly Ile Arg Glu Trp Trp Ala Leu Lys Pro Gly Ala Pro           
15                  20                  25                  30            

caa ccc aag gca aat caa caa cat caa gac aac gct aga ggt ctt gtg       4285
Gln Pro Lys Ala Asn Gln Gln His Gln Asp Asn Ala Arg Gly Leu Val           
                35                  40                  45                

ctt ccg ggt tac aaa tac ctt gga ccc ggc aac gga ctc gac aag ggg       4333
Leu Pro Gly Tyr Lys Tyr Leu Gly Pro Gly Asn Gly Leu Asp Lys Gly           
            50                  55                  60                    

gag ccg gtc aac gca gca gac gcg gcg gcc ctc gag cac gac aaa gcc       4381
Glu Pro Val Asn Ala Ala Asp Ala Ala Ala Leu Glu His Asp Lys Ala           
        65                  70                  75                        

tac gac cag cag ctc aag gcc gga gac aac ccg tac ctc aag tac aac       4429
Tyr Asp Gln Gln Leu Lys Ala Gly Asp Asn Pro Tyr Leu Lys Tyr Asn           
    80                  85                  90                            

cac gcc gac gcc gag ttc cag gag cgg ctc aaa gaa gat acg tct ttt       4477
His Ala Asp Ala Glu Phe Gln Glu Arg Leu Lys Glu Asp Thr Ser Phe           
95                  100                 105                 110           

ggg ggc aac ctc ggg cga gca gtc ttc cag gcc aaa aag agg ctt ctt       4525
Gly Gly Asn Leu Gly Arg Ala Val Phe Gln Ala Lys Lys Arg Leu Leu           
                115                 120                 125               

gaa cct ctt ggt ctg gtt gag gaa gcg gct aag acg gct cct gga aag       4573
Glu Pro Leu Gly Leu Val Glu Glu Ala Ala Lys Thr Ala Pro Gly Lys           
            130                 135                 140                   

aag agg cct gta gag cag tct cct cag gaa ccg gac tcc tcc gcg ggt       4621
Lys Arg Pro Val Glu Gln Ser Pro Gln Glu Pro Asp Ser Ser Ala Gly           
        145                 150                 155                       

att ggc aaa tcg ggt gca cag ccc gct aaa aag aga ctc aat ttc ggt       4669
Ile Gly Lys Ser Gly Ala Gln Pro Ala Lys Lys Arg Leu Asn Phe Gly           
    160                 165                 170                           

cag act ggc gac aca gag tca gtc cca gac cct caa cca atc gga gaa       4717
Gln Thr Gly Asp Thr Glu Ser Val Pro Asp Pro Gln Pro Ile Gly Glu           
175                 180                 185                 190           

cct ccc gca gcc ccc tca ggt gtg gga tct ctt aca atg gct tca ggt       4765
Pro Pro Ala Ala Pro Ser Gly Val Gly Ser Leu Thr Met Ala Ser Gly           
                195                 200                 205               

ggt ggc gca cca gtg gca gac aat aac gaa ggt gcc gat gga gtg ggt       4813
Gly Gly Ala Pro Val Ala Asp Asn Asn Glu Gly Ala Asp Gly Val Gly           
            210                 215                 220                   

agt tcc tcg gga aat tgg cat tgc gat tcc caa tgg ctg ggg gac aga       4861
Ser Ser Ser Gly Asn Trp His Cys Asp Ser Gln Trp Leu Gly Asp Arg           
        225                 230                 235                       

gtc atc acc acc agc acc cga acc tgg gcc ctg ccc acc tac aac aat       4909
Val Ile Thr Thr Ser Thr Arg Thr Trp Ala Leu Pro Thr Tyr Asn Asn           
    240                 245                 250                           

cac ctc tac aag caa atc tcc aac agc aca tct gga gga tct tca aat       4957
His Leu Tyr Lys Gln Ile Ser Asn Ser Thr Ser Gly Gly Ser Ser Asn           
255                 260                 265                 270           

gac aac gcc tac ttc ggc tac agc acc ccc tgg ggg tat ttt gac ttc       5005
Asp Asn Ala Tyr Phe Gly Tyr Ser Thr Pro Trp Gly Tyr Phe Asp Phe           
                275                 280                 285               

aac aga ttc cac tgc cac ttc tca cca cgt gac tgg cag cga ctc atc       5053
Asn Arg Phe His Cys His Phe Ser Pro Arg Asp Trp Gln Arg Leu Ile           
            290                 295                 300                   

aac aac aac tgg gga ttc cgg cct aag cga ctc aac ttc aag ctc ttt       5101
Asn Asn Asn Trp Gly Phe Arg Pro Lys Arg Leu Asn Phe Lys Leu Phe           
        305                 310                 315                       

aac att cag gtc aaa gag gtt acg gac aac aat gga gtc aag acc atc       5149
Asn Ile Gln Val Lys Glu Val Thr Asp Asn Asn Gly Val Lys Thr Ile           
    320                 325                 330                           

gcc aat aac ctt acc agc acg gtc cag gtc ttc acg gac tca gac tat       5197
Ala Asn Asn Leu Thr Ser Thr Val Gln Val Phe Thr Asp Ser Asp Tyr           
335                 340                 345                 350           

cag ctc ccg tac gtg ctc ggg tcg gct cac gag ggc tgc ctc ccg ccg       5245
Gln Leu Pro Tyr Val Leu Gly Ser Ala His Glu Gly Cys Leu Pro Pro           
                355                 360                 365               

ttc cca gcg gac gtt ttc atg att cct cag tac ggg tat ctg acg ctt       5293
Phe Pro Ala Asp Val Phe Met Ile Pro Gln Tyr Gly Tyr Leu Thr Leu           
            370                 375                 380                   

aat gat gga agc cag gcc gtg ggt cgt tcg tcc ttt tac tgc ctg gaa       5341
Asn Asp Gly Ser Gln Ala Val Gly Arg Ser Ser Phe Tyr Cys Leu Glu           
        385                 390                 395                       

tat ttc ccg tcg caa atg cta aga acg ggt aac aac ttc cag ttc agc       5389
Tyr Phe Pro Ser Gln Met Leu Arg Thr Gly Asn Asn Phe Gln Phe Ser           
    400                 405                 410                           

tac gag ttt gag aac gta cct ttc cat agc agc tac gct cac agc caa       5437
Tyr Glu Phe Glu Asn Val Pro Phe His Ser Ser Tyr Ala His Ser Gln           
415                 420                 425                 430           

agc ctg gac cga cta atg aat cca ctc atc gac caa tac ttg tac tat       5485
Ser Leu Asp Arg Leu Met Asn Pro Leu Ile Asp Gln Tyr Leu Tyr Tyr           
                435                 440                 445               

ctc tct aga act att aac ggt tct gga cag aat caa caa acg cta aaa       5533
Leu Ser Arg Thr Ile Asn Gly Ser Gly Gln Asn Gln Gln Thr Leu Lys           
            450                 455                 460                   

ttc agt gtg gcc gga ccc agc aac atg gct gtc cag gga aga aac tac       5581
Phe Ser Val Ala Gly Pro Ser Asn Met Ala Val Gln Gly Arg Asn Tyr           
        465                 470                 475                       

ata cct gga ccc agc tac cga caa caa cgt gtc tca acc act gtg act       5629
Ile Pro Gly Pro Ser Tyr Arg Gln Gln Arg Val Ser Thr Thr Val Thr           
    480                 485                 490                           

caa aac aac aac agc gaa ttt gct tgg cct gga gct tct tct tgg gct       5677
Gln Asn Asn Asn Ser Glu Phe Ala Trp Pro Gly Ala Ser Ser Trp Ala           
495                 500                 505                 510           

ctc aat gga cgt aat agc ttg atg aat cct gga cct gct atg gcc tct       5725
Leu Asn Gly Arg Asn Ser Leu Met Asn Pro Gly Pro Ala Met Ala Ser           
                515                 520                 525               

cac aaa gaa gga gag gac cgt ttc ttt cct ttg tct gga tct tta att       5773
His Lys Glu Gly Glu Asp Arg Phe Phe Pro Leu Ser Gly Ser Leu Ile           
            530                 535                 540                   

ttt ggc aaa caa ggt act ggc aga gac aac gtg gat gcg gac aaa gtc       5821
Phe Gly Lys Gln Gly Thr Gly Arg Asp Asn Val Asp Ala Asp Lys Val           
        545                 550                 555                       

atg ata acc aac gaa gaa gaa att aaa act act aac ccg gta gca acg       5869
Met Ile Thr Asn Glu Glu Glu Ile Lys Thr Thr Asn Pro Val Ala Thr           
    560                 565                 570                           

gag tcc tat gga caa gtg gcc aca aac cac cag agt gat ggg act ttg       5917
Glu Ser Tyr Gly Gln Val Ala Thr Asn His Gln Ser Asp Gly Thr Leu           
575                 580                 585                 590           

gcg gtg cct ttt aag gca cag gcg cag acc ggt tgg gtt caa aac caa       5965
Ala Val Pro Phe Lys Ala Gln Ala Gln Thr Gly Trp Val Gln Asn Gln           
                595                 600                 605               

gga ata ctt ccg ggt atg gtt tgg cag gac aga gat gtg tac ctg caa       6013
Gly Ile Leu Pro Gly Met Val Trp Gln Asp Arg Asp Val Tyr Leu Gln           
            610                 615                 620                   

gga ccc att tgg gcc aaa att cct cac acg gac ggc aac ttt cac cct       6061
Gly Pro Ile Trp Ala Lys Ile Pro His Thr Asp Gly Asn Phe His Pro           
        625                 630                 635                       

tct ccg ctg atg gga ggg ttt gga atg aag cac ccg cct cct cag atc       6109
Ser Pro Leu Met Gly Gly Phe Gly Met Lys His Pro Pro Pro Gln Ile           
    640                 645                 650                           

ctc atc aaa aac aca cct gta cct gcg gat cct cca acg gcc ttc aac       6157
Leu Ile Lys Asn Thr Pro Val Pro Ala Asp Pro Pro Thr Ala Phe Asn           
655                 660                 665                 670           

aag gac aag ctg aac tct ttc atc acc cag tat tct act ggt caa gtc       6205
Lys Asp Lys Leu Asn Ser Phe Ile Thr Gln Tyr Ser Thr Gly Gln Val           
                675                 680                 685               

agc gtg gag atc gag tgg gag ctg cag aag gaa aac agc aag cgc tgg       6253
Ser Val Glu Ile Glu Trp Glu Leu Gln Lys Glu Asn Ser Lys Arg Trp           
            690                 695                 700                   

aac ccg gag atc cag tac act tcc aac tat tac aag tct aat aat gtt       6301
Asn Pro Glu Ile Gln Tyr Thr Ser Asn Tyr Tyr Lys Ser Asn Asn Val           
        705                 710                 715                       

gaa ttt gct gtt aat act gaa ggt gta tat agt gaa ccc cgc ccc att       6349
Glu Phe Ala Val Asn Thr Glu Gly Val Tyr Ser Glu Pro Arg Pro Ile           
    720                 725                 730                           

ggc acc aga tac ctg act cgt aat ctg taagtcgact tgcttgttaa             6396
Gly Thr Arg Tyr Leu Thr Arg Asn Leu                                       
735                 740                                                   

tcaataaacc gtttaattcg tttcagttga actttggtct ctgcgaaggg caattcgttt     6456

aaacctgcag gactagaggt cctgtattag aggtcacgtg agtgttttgc gacattttgc     6516

gacaccatgt ggtcacgctg ggtatttaag cccgagtgag cacgcagggt ctccattttg     6576

aagcgggagg tttgaacgcg cagccgccaa gccgaattct gcagatatca catgtcctag     6636

gaactatcga tccatcacac tggcggccgc tcgactagag cggccgccac cgcggtggag     6696

ctccagcttt tgcggaccga atcggaaaga acatgtgagc aaaaggccag caaaaggcca     6756

ggaaccgtaa aaaggccgcg ttgctggcgt ttttccatag gctccgcccc cctgacgagc     6816

atcacaaaaa tcgacgctca agtcagaggt ggcgaaaccc gacaggacta taaagatacc     6876

aggcgtttcc ccctggaagc tccctcgtgc gctctcctgt tccgaccctg ccgcttaccg     6936

gatacctgtc cgcctttctc ccttcgggaa gcgtggcgct ttctcatagc tcacgctgta     6996

ggtatctcag ttcggtgtag gtcgttcgct ccaagctggg ctgtgtgcac gaaccccccg     7056

ttcagcccga ccgctgcgcc ttatccggta actatcgtct tgagtccaac ccggtaagac     7116

acgacttatc gccactggca gcagccactg gtaacaggat tagcagagcg aggtatgtag     7176

gcggtgctac agagttcttg aagtggtggc ctaactacgg ctacactaga agaacagtat     7236

ttggtatctg cgctctgctg aagccagtta ccttcggaaa aagagttggt agctcttgat     7296

ccggcaaaca aaccaccgct ggtagcggtg gtttttttgt ttgcaagcag cagattacgc     7356

gcagaaaaaa aggatctcaa gaagatcctt tgatcttttc tacggggtct gacgctcagt     7416

ggaacgaaaa ctcacgttaa gggattttgg tcatgagatt atcaaaaagg atcttcacct     7476

agatcctttt aaattaaaaa tgaagtttta aatcaatcta aagtatatat gagtaaactt     7536

ggtctgacag ttaccaatgc ttaatcagtg aggcacctat ctcagcgatc tgtctatttc     7596

gttcatccat agttgcctga ctccccgtcg tgtagataac tacgatacgg gagggcttac     7656

catctggccc cagtgctgca atgataccgc gagacccacg ctcaccggct ccagatttat     7716

cagcaataaa ccagccagcc ggaagggccg agcgcagaag tggtcctgca actttatccg     7776

cctccatcca gtctattaat tgttgccggg aagctagagt aagtagttcg ccagttaata     7836

gtttgcgcaa cgttgttgcc attgctacag gcatcgtggt gtcacgctcg tcgtttggta     7896

tggcttcatt cagctccggt tcccaacgat caaggcgagt tacatgatcc cccatgttgt     7956

gcaaaaaagc ggttagctcc ttcggtcctc cgatcgttgt cagaagtaag ttggccgcag     8016

tgttatcact catggttatg gcagcactgc ataattctct tactgtcatg ccatccgtaa     8076

gatgcttttc tgtgactggt gagtactcaa ccaagtcatt ctgagaatag tgtatgcggc     8136

gaccgagttg ctcttgcccg gcgtcaatac gggataatac cgcgccacat agcagaactt     8196

taaaagtgct catcattgga aaacgttctt cggggcgaaa actctcaagg atcttaccgc     8256

tgttgagatc cagttcgatg taacccactc gtgcacccaa ctgatcttca gcatctttta     8316

ctttcaccag cgtttctggg tgagcaaaaa caggaaggca aaatgccgca aaaaagggaa     8376

taagggcgac acggaaatgt tgaatactca tactcttcct ttttcaatat tattgaagca     8436

tttatcaggg ttattgtctc atgagcggat acatatttga atgtatttag aaaaataaac     8496

aaataggggt tccgcgcaca tttccccgaa aagtgccacc tgacgtc                   8543


<210>  21
<211>  743
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic Construct

<400>  21

Met Ala Ala Asp Gly Tyr Leu Pro Asp Trp Leu Glu Asp Asn Leu Ser 
1               5                   10                  15      


Glu Gly Ile Arg Glu Trp Trp Ala Leu Lys Pro Gly Ala Pro Gln Pro 
            20                  25                  30          


Lys Ala Asn Gln Gln His Gln Asp Asn Ala Arg Gly Leu Val Leu Pro 
        35                  40                  45              


Gly Tyr Lys Tyr Leu Gly Pro Gly Asn Gly Leu Asp Lys Gly Glu Pro 
    50                  55                  60                  


Val Asn Ala Ala Asp Ala Ala Ala Leu Glu His Asp Lys Ala Tyr Asp 
65                  70                  75                  80  


Gln Gln Leu Lys Ala Gly Asp Asn Pro Tyr Leu Lys Tyr Asn His Ala 
                85                  90                  95      


Asp Ala Glu Phe Gln Glu Arg Leu Lys Glu Asp Thr Ser Phe Gly Gly 
            100                 105                 110         


Asn Leu Gly Arg Ala Val Phe Gln Ala Lys Lys Arg Leu Leu Glu Pro 
        115                 120                 125             


Leu Gly Leu Val Glu Glu Ala Ala Lys Thr Ala Pro Gly Lys Lys Arg 
    130                 135                 140                 


Pro Val Glu Gln Ser Pro Gln Glu Pro Asp Ser Ser Ala Gly Ile Gly 
145                 150                 155                 160 


Lys Ser Gly Ala Gln Pro Ala Lys Lys Arg Leu Asn Phe Gly Gln Thr 
                165                 170                 175     


Gly Asp Thr Glu Ser Val Pro Asp Pro Gln Pro Ile Gly Glu Pro Pro 
            180                 185                 190         


Ala Ala Pro Ser Gly Val Gly Ser Leu Thr Met Ala Ser Gly Gly Gly 
        195                 200                 205             


Ala Pro Val Ala Asp Asn Asn Glu Gly Ala Asp Gly Val Gly Ser Ser 
    210                 215                 220                 


Ser Gly Asn Trp His Cys Asp Ser Gln Trp Leu Gly Asp Arg Val Ile 
225                 230                 235                 240 


Thr Thr Ser Thr Arg Thr Trp Ala Leu Pro Thr Tyr Asn Asn His Leu 
                245                 250                 255     


Tyr Lys Gln Ile Ser Asn Ser Thr Ser Gly Gly Ser Ser Asn Asp Asn 
            260                 265                 270         


Ala Tyr Phe Gly Tyr Ser Thr Pro Trp Gly Tyr Phe Asp Phe Asn Arg 
        275                 280                 285             


Phe His Cys His Phe Ser Pro Arg Asp Trp Gln Arg Leu Ile Asn Asn 
    290                 295                 300                 


Asn Trp Gly Phe Arg Pro Lys Arg Leu Asn Phe Lys Leu Phe Asn Ile 
305                 310                 315                 320 


Gln Val Lys Glu Val Thr Asp Asn Asn Gly Val Lys Thr Ile Ala Asn 
                325                 330                 335     


Asn Leu Thr Ser Thr Val Gln Val Phe Thr Asp Ser Asp Tyr Gln Leu 
            340                 345                 350         


Pro Tyr Val Leu Gly Ser Ala His Glu Gly Cys Leu Pro Pro Phe Pro 
        355                 360                 365             


Ala Asp Val Phe Met Ile Pro Gln Tyr Gly Tyr Leu Thr Leu Asn Asp 
    370                 375                 380                 


Gly Ser Gln Ala Val Gly Arg Ser Ser Phe Tyr Cys Leu Glu Tyr Phe 
385                 390                 395                 400 


Pro Ser Gln Met Leu Arg Thr Gly Asn Asn Phe Gln Phe Ser Tyr Glu 
                405                 410                 415     


Phe Glu Asn Val Pro Phe His Ser Ser Tyr Ala His Ser Gln Ser Leu 
            420                 425                 430         


Asp Arg Leu Met Asn Pro Leu Ile Asp Gln Tyr Leu Tyr Tyr Leu Ser 
        435                 440                 445             


Arg Thr Ile Asn Gly Ser Gly Gln Asn Gln Gln Thr Leu Lys Phe Ser 
    450                 455                 460                 


Val Ala Gly Pro Ser Asn Met Ala Val Gln Gly Arg Asn Tyr Ile Pro 
465                 470                 475                 480 


Gly Pro Ser Tyr Arg Gln Gln Arg Val Ser Thr Thr Val Thr Gln Asn 
                485                 490                 495     


Asn Asn Ser Glu Phe Ala Trp Pro Gly Ala Ser Ser Trp Ala Leu Asn 
            500                 505                 510         


Gly Arg Asn Ser Leu Met Asn Pro Gly Pro Ala Met Ala Ser His Lys 
        515                 520                 525             


Glu Gly Glu Asp Arg Phe Phe Pro Leu Ser Gly Ser Leu Ile Phe Gly 
    530                 535                 540                 


Lys Gln Gly Thr Gly Arg Asp Asn Val Asp Ala Asp Lys Val Met Ile 
545                 550                 555                 560 


Thr Asn Glu Glu Glu Ile Lys Thr Thr Asn Pro Val Ala Thr Glu Ser 
                565                 570                 575     


Tyr Gly Gln Val Ala Thr Asn His Gln Ser Asp Gly Thr Leu Ala Val 
            580                 585                 590         


Pro Phe Lys Ala Gln Ala Gln Thr Gly Trp Val Gln Asn Gln Gly Ile 
        595                 600                 605             


Leu Pro Gly Met Val Trp Gln Asp Arg Asp Val Tyr Leu Gln Gly Pro 
    610                 615                 620                 


Ile Trp Ala Lys Ile Pro His Thr Asp Gly Asn Phe His Pro Ser Pro 
625                 630                 635                 640 


Leu Met Gly Gly Phe Gly Met Lys His Pro Pro Pro Gln Ile Leu Ile 
                645                 650                 655     


Lys Asn Thr Pro Val Pro Ala Asp Pro Pro Thr Ala Phe Asn Lys Asp 
            660                 665                 670         


Lys Leu Asn Ser Phe Ile Thr Gln Tyr Ser Thr Gly Gln Val Ser Val 
        675                 680                 685             


Glu Ile Glu Trp Glu Leu Gln Lys Glu Asn Ser Lys Arg Trp Asn Pro 
    690                 695                 700                 


Glu Ile Gln Tyr Thr Ser Asn Tyr Tyr Lys Ser Asn Asn Val Glu Phe 
705                 710                 715                 720 


Ala Val Asn Thr Glu Gly Val Tyr Ser Glu Pro Arg Pro Ile Gly Thr 
                725                 730                 735     


Arg Tyr Leu Thr Arg Asn Leu 
            740             


<210>  22
<211>  2229
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  constructed sequence

<400>  22
atggctgccg atggttatct tccagattgg ctcgaggaca accttagtga aggaattcgc       60

gagtggtggg ctttgaaacc tggagcccct caacccaagg caaatcaaca acatcaagac      120

aacgctagag gtcttgtgct tccgggttac aaataccttg gacccggcaa cggactcgac      180

aagggggagc cggtcaacgc agcagacgcg gcggccctcg agcacgacaa agcctacgac      240

cagcagctca aggccggaga caacccgtac ctcaagtaca accacgccga cgccgagttc      300

caggagcggc tcaaagaaga tacgtctttt gggggcaacc tcgggcgagc agtcttccag      360

gccaaaaaga ggcttcttga acctcttggt ctggttgagg aagcggctaa gacggctcct      420

ggaaagaaga ggcctgtaga gcagtctcct caggaaccgg actcctccgc gggtattggc      480

aaatcgggtg cacagcccgc taaaaagaga ctcaatttcg gtcagactgg cgacacagag      540

tcagtcccag accctcaacc aatcggagaa cctcccgcag ccccctcagg tgtgggatct      600

cttacaatgg cttcaggtgg tggcgcacca gtggcagaca ataacgaagg tgccgatgga      660

gtgggtagtt cctcgggaaa ttggcattgc gattcccaat ggctggggga cagagtcatc      720

accaccagca cccgaacctg ggccctgccc acctacaaca atcacctcta caagcaaatc      780

tccaacagca catctggagg atcttcaaat gacaacgcct acttcggcta cagcaccccc      840

tgggggtatt ttgacttcaa cagattccac tgccacttct caccacgtga ctggcagcga      900

ctcatcaaca acaactgggg attccggcct aagcgactca acttcaagct ctttaacatt      960

caggtcaaag aggttacgga caacaatgga gtcaagacca tcgccaataa ccttaccagc     1020

acggtccagg tcttcacgga ctcagactat cagctcccgt acgtgctcgg gtcggctcac     1080

gagggctgcc tcccgccgtt cccagcggac gttttcatga ttcctcagta cgggtatctg     1140

acgcttaatg atggaagcca ggccgtgggt cgttcgtcct tttactgcct ggaatatttc     1200

ccgtcgcaaa tgctaagaac gggtaacaac ttccagttca gctacgagtt tgagaacgta     1260

cctttccata gcagctacgc tcacagccaa agcctggacc gactaatgaa tccactcatc     1320

gaccaatact tgtactatct ctctagaact attaacggtt ctggacagaa tcaacaaacg     1380

ctaaaattca gtgtggccgg acccagcaac atggctgtcc agggaagaaa ctacatacct     1440

ggacccagct accgacaaca acgtgtctca accactgtga ctcaaaacaa caacagcgaa     1500

tttgcttggc ctggagcttc ttcttgggct ctcaatggac gtaatagctt gatgaatcct     1560

ggacctgcta tggcctctca caaagaagga gaggaccgtt tctttccttt gtctggatct     1620

ttaatttttg gcaaacaagg tactggcaga gacaacgtgg atgcggacaa agtcatgata     1680

accaacgaag aagaaattaa aactactaac ccggtagcaa cggagtccta tggacaagtg     1740

gccacaaacc accagagtga tgggactttg gcggtgcctt ttaaggcaca ggcgcagacc     1800

ggttgggttc aaaaccaagg aatacttccg ggtatggttt ggcaggacag agatgtgtac     1860

ctgcaaggac ccatttgggc caaaattcct cacacggacg gcaactttca cccttctccg     1920

ctgatgggag ggtttggaat gaagcacccg cctcctcaga tcctcatcaa aaacacacct     1980

gtacctgcgg atcctccaac ggccttcaac aaggacaagc tgaactcttt catcacccag     2040

tattctactg gtcaagtcag cgtggagatc gagtgggagc tgcagaagga aaacagcaag     2100

cgctggaacc cggagatcca gtacacttcc aactattaca agtctaataa tgttgaattt     2160

gctgttaata ctgaaggtgt atatagtgaa ccccgcccca ttggcaccag atacctgact     2220

cgtaatctg                                                             2229


<210>  23
<211>  841
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  CB7 Promoter with CMV enhancer

<400>  23
ccattgacgt caataatgac gtatgttccc atagtaacgc caatagggac tttccattga       60

cgtcaatggg tggagtattt acggtaaact gcccacttgg cagtacatca agtgtatcat      120

atgccaagta cgccccctat tgacgtcaat gacggtaaat ggcccgcctg gcattatgcc      180

cagtacatga ccttatggga ctttcctact tggcagtaca tctacgtatt agtcatcgct      240

attaccatgg tcgaggtgag ccccacgttc tgcttcactc tccccatctc ccccccctcc      300

ccacccccaa ttttgtattt atttattttt taattatttt gtgcagcgat gggggcgggg      360

gggggggggg ggcgcgcgcc aggcggggcg gggcggggcg aggggcgggg cggggcgagg      420

cggagaggtg cggcggcagc caatcagagc ggcgcgctcc gaaagtttcc ttttatggcg      480

aggcggcggc ggcggcggcc ctataaaaag cgaagcgcgc ggcgggcggg agtcgctgcg      540

cgctgccttc gccccgtgcc ccgctccgcc gccgcctcgc gccgcccgcc ccggctctga      600

ctgaccgcgt tactcccaca ggtgagcggg cgggacggcc cttctcctcc gggctgtaat      660

tagcgcttgg tttaatgacg gcttgtttct tttctgtggc tgcgtgaaag ccttgagggg      720

ctccgggagg gccctttgtg cggggggagc ggctcggggc tgtccgcggg gggacggctg      780

ccttcggggg ggacggggca gggcggggtt cggcttctgg cgtgtgaccg gcggctctag      840

a                                                                      841


<210>  24
<211>  1649
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  CAG promoter

<400>  24
cgttacataa cttacggtaa atggcccgcc tggctgaccg cccaacgacc cccgcccatt       60

gacgtcaata atgacgtatg ttcccatagt aacgccaata gggactttcc attgacgtca      120

atgggtggag tatttacggt aaactgccca cttggcagta catcaagtgt atcatatgcc      180

aagtacgccc cctattgacg tcaatgacgg taaatggccc gcctggcatt atgcccagta      240

catgacctta tgggactttc ctacttggca gtacatctac gtattagtca tcgctattac      300

catggtcgag gtgagcccca cgttctgctt cactctcccc atctcccccc cctccccacc      360

cccaattttg tatttattta ttttttaatt attttgtgca gcgatggggg cggggggggg      420

gggggggcgc gcgccaggcg gggcggggcg gggcgagggg cggggcgggg cgaggcggag      480

aggtgcggcg gcagccaatc agagcggcgc gctccgaaag tttcctttta tggcgaggcg      540

gcggcggcgg cggccctata aaaagcgaag cgcgcggcgg gcgggagtcg ctgcgcgctg      600

ccttcgcccc gtgccccgct ccgccgccgc ctcgcgccgc ccgccccggc tctgactgac      660

cgcgttactc ccacaggtga gcgggcggga cggcccttct cctccgggct gtaattagcg      720

cttggtttaa tgacggcttg tttcttttct gtggctgcgt gaaagccttg aggggctccg      780

ggagggccct ttgtgcgggg ggagcggctc ggggggtgcg tgcgtgtgtg tgtgcgtggg      840

gagcgccgcg tgcggctccg cgctgcccgg cggctgtgag cgctgcgggc gcggcgcggg      900

gctttgtgcg ctccgcagtg tgcgcgaggg gagcgcggcc gggggcggtg ccccgcggtg      960

cggggggggc tgcgagggga acaaaggctg cgtgcggggt gtgtgcgtgg gggggtgagc     1020

agggggtgtg ggcgcgtcgg tcgggctgca accccccctg cacccccctc cccgagttgc     1080

tgagcacggc ccggcttcgg gtgcggggct ccgtacgggg cgtggcgcgg ggctcgccgt     1140

gccgggcggg gggtggcggc aggtgggggt gccgggcggg gcggggccgc ctcgggccgg     1200

ggagggctcg ggggaggggc gcggcggccc ccggagcgcc ggcggctgtc gaggcgcggc     1260

gagccgcagc cattgccttt tatggtaatc gtgcgagagg gcgcagggac ttcctttgtc     1320

ccaaatctgt gcggagccga aatctgggag gcgccgccgc accccctcta gcgggcgcgg     1380

ggcgaagcgg tgcggcgccg gcaggaagga aatgggcggg gagggccttc gtgcgtcgcc     1440

gcgccgccgt ccccttctcc ctctccagcc tcggggctgt ccgcgggggg acggctgcct     1500

tcggggggga cggggcaggg cggggttcgg cttctggcgt gtgaccggcg gctctagagc     1560

ctctgctaac catgttcatg ccttcttctt tttcctacag ctcctgggca acgtgctggt     1620

tattgtgctg tctcatcatt ttggcaaag                                       1649


<210>  25
<211>  127
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  rabbit beta-globin

<400>  25
gatctttttc cctctgccaa aaattatggg gacatcatga agccccttga gcatctgact       60

tctggctaat aaaggaaatt tattttcatt gcaatagtgt gttggaattt tttgtgtctc      120

tcactcg                                                                127


<210>  26
<211>  2701
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Constructed sequence

<400>  26
cgttacataa cttacggtaa atggcccgcc tggctgaccg cccaacgacc cccgcccatt       60

gacgtcaata atgacgtatg ttcccatagt aacgccaata gggactttcc attgacgtca      120

atgggtggag tatttacggt aaactgccca cttggcagta catcaagtgt atcatatgcc      180

aagtacgccc cctattgacg tcaatgacgg taaatggccc gcctggcatt atgcccagta      240

catgacctta tgggactttc ctacttggca gtacatctac gtattagtca tcgctattac      300

catggtcgag gtgagcccca cgttctgctt cactctcccc atctcccccc cctccccacc      360

cccaattttg tatttattta ttttttaatt attttgtgca gcgatggggg cggggggggg      420

gggggggcgc gcgccaggcg gggcggggcg gggcgagggg cggggcgggg cgaggcggag      480

aggtgcggcg gcagccaatc agagcggcgc gctccgaaag tttcctttta tggcgaggcg      540

gcggcggcgg cggccctata aaaagcgaag cgcgcggcgg gcgggagtcg ctgcgcgctg      600

ccttcgcccc gtgccccgct ccgccgccgc ctcgcgccgc ccgccccggc tctgactgac      660

cgcgttactc ccacaggtga gcgggcggga cggcccttct cctccgggct gtaattagcg      720

cttggtttaa tgacggcttg tttcttttct gtggctgcgt gaaagccttg aggggctccg      780

ggagggccct ttgtgcgggg ggagcggctc ggggggtgcg tgcgtgtgtg tgtgcgtggg      840

gagcgccgcg tgcggctccg cgctgcccgg cggctgtgag cgctgcgggc gcggcgcggg      900

gctttgtgcg ctccgcagtg tgcgcgaggg gagcgcggcc gggggcggtg ccccgcggtg      960

cggggggggc tgcgagggga acaaaggctg cgtgcggggt gtgtgcgtgg gggggtgagc     1020

agggggtgtg ggcgcgtcgg tcgggctgca accccccctg cacccccctc cccgagttgc     1080

tgagcacggc ccggcttcgg gtgcggggct ccgtacgggg cgtggcgcgg ggctcgccgt     1140

gccgggcggg gggtggcggc aggtgggggt gccgggcggg gcggggccgc ctcgggccgg     1200

ggagggctcg ggggaggggc gcggcggccc ccggagcgcc ggcggctgtc gaggcgcggc     1260

gagccgcagc cattgccttt tatggtaatc gtgcgagagg gcgcagggac ttcctttgtc     1320

ccaaatctgt gcggagccga aatctgggag gcgccgccgc accccctcta gcgggcgcgg     1380

ggcgaagcgg tgcggcgccg gcaggaagga aatgggcggg gagggccttc gtgcgtcgcc     1440

gcgccgccgt ccccttctcc ctctccagcc tcggggctgt ccgcgggggg acggctgcct     1500

tcggggggga cggggcaggg cggggttcgg cttctggcgt gtgaccggcg gctctagagc     1560

ctctgctaac catgttcatg ccttcttctt tttcctacag ctcctgggca acgtgctggt     1620

tattgtgctg tctcatcatt ttggcaaaga attcacgcgt gctagctctg gaggcttgct     1680

gaaggctgta tgctgtcgag ttccttgatg tagttcgttt tggccactga ctgacgaact     1740

acaaaggaac tcgacaggac acaaggcctg ttactagcac tcacatggaa caaatggccc     1800

agatctaggg tggggccacc tgccggtagg tgtgcggtag gcttttctcc gtcgcaggac     1860

gcagggttcg ggcctagctt atcgataatc aacctctgga ttacaaaatt tgtgaaagat     1920

tgactggtat tcttaactat gttgctcctt ttacgctatg tggatacgct gctttaatgc     1980

ctttgtatca tgctattgct tcccgtatgg ctttcatttt ctcctccttg tataaatcct     2040

ggttgctgtc tctttatgag gagttgtggc ccgttgtcag gcaacgtggc gtggtgtgca     2100

ctgtgtttgc tgacgcaacc cccactggtt ggggcattgc caccacctgt cagctccttt     2160

ccgggacttt cgctttcccc ctccctattg ccacggcgga actcatcgcc gcctgccttg     2220

cccgctgctg gacaggggct cggctgttgg gcactgacaa ttccgtggtg ttgtcgggga     2280

aatcatcgtc ctttccttgg ctgctcgcct gtgttgccac ctggattctg cgcgggacgc     2340

ccttctgcta cgtcccttcg gccctcaatc cagcggacct tccttcccgc ggcctgctgc     2400

cggctctgcg gcctcttccg cgtcttcgcc ttcgccctca gacgagtcgg atctcccttt     2460

gggccgcctc cccgcctgct gatcgccctg agcctggccc tggtgaccaa cagccaggtg     2520

caattgaagc tttctagagt cgacccgggc ggcggcggcc gcctaaggct cgaggatctt     2580

tttccctctg ccaaaaatta tggggacatc atgaagcccc ttgagcatct gacttctggc     2640

taataaagga aatttatttt cattgcaata gtgtgttgga attttttgtg tctctcactc     2700

g                                                                     2701


<210>  27
<211>  21
<212>  DNA
<213>  Homo sapiens

<400>  27
ctacatcaag gaactcgatc g                                                 21


