                         SEQUENCE LISTING

<110>  The Regents of the University of California, UCSD
       WELSBIE, Derek S.
       VU, Mai T.
       LEE, Cassidy D.
       PATEL, Amit K.
 
<120>  GENE THERAPY FOR NEUROPROTECTION

<130>  048537-644001WO

<140>  PCT/US22/24310
<141>  2022-04-11

<150>  63/190,132
<151>  2021-05-18

<150>  63/173,904
<151>  2021-04-12

<160>  14    

<170>  PatentIn version 3.5

<210>  1
<211>  892
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic Polypeptide

<400>  1

Met Ala Cys Leu His Glu Thr Arg Thr Pro Ser Pro Ser Phe Gly Gly 
1               5                   10                  15      


Phe Val Ser Thr Leu Ser Glu Ala Ser Met Arg Lys Leu Asp Pro Asp 
            20                  25                  30          


Thr Ser Asp Cys Thr Pro Glu Lys Asp Leu Thr Pro Thr Gln Cys Val 
        35                  40                  45              


Leu Arg Asp Val Val Pro Leu Gly Gly Gln Gly Gly Gly Gly Pro Ser 
    50                  55                  60                  


Pro Ser Pro Gly Gly Glu Pro Pro Pro Glu Pro Phe Ala Asn Ser Val 
65                  70                  75                  80  


Leu Gln Leu His Glu Gln Asp Ala Gly Gly Pro Gly Gly Ala Ala Gly 
                85                  90                  95      


Ser Pro Glu Ser Arg Ala Ser Arg Val Arg Ala Asp Glu Val Arg Leu 
            100                 105                 110         


Gln Cys Gln Ser Gly Ser Gly Phe Leu Glu Gly Leu Phe Gly Cys Leu 
        115                 120                 125             


Arg Pro Val Trp Thr Met Ile Gly Lys Ala Tyr Ser Thr Glu His Lys 
    130                 135                 140                 


Gln Gln Gln Glu Asp Leu Trp Glu Val Pro Phe Glu Glu Ile Leu Asp 
145                 150                 155                 160 


Leu Gln Trp Val Gly Ser Gly Ala Gln Gly Ala Val Phe Leu Gly Arg 
                165                 170                 175     


Phe His Gly Glu Glu Val Ala Val Lys Lys Val Arg Asp Leu Lys Glu 
            180                 185                 190         


Thr Asp Ile Lys His Leu Arg Lys Leu Lys His Pro Asn Ile Ile Thr 
        195                 200                 205             


Phe Lys Gly Val Cys Thr Gln Ala Pro Cys Tyr Cys Ile Leu Met Glu 
    210                 215                 220                 


Phe Cys Ala Gln Gly Gln Leu Tyr Glu Val Leu Arg Ala Gly Arg Pro 
225                 230                 235                 240 


Val Thr Pro Ser Leu Leu Val Asp Trp Ser Met Gly Ile Ala Gly Gly 
                245                 250                 255     


Met Asn Tyr Leu His Leu His Lys Ile Ile His Arg Asp Leu Lys Ser 
            260                 265                 270         


Pro Asn Met Leu Ile Thr Tyr Asp Asp Val Val Lys Ile Ser Asp Phe 
        275                 280                 285             


Gly Thr Ser Lys Glu Leu Ser Asp Lys Ser Thr Lys Met Ser Phe Ala 
    290                 295                 300                 


Gly Thr Val Ala Trp Met Ala Pro Glu Val Ile Arg Asn Glu Pro Val 
305                 310                 315                 320 


Ser Glu Lys Val Asp Ile Trp Ser Phe Gly Val Val Leu Trp Glu Leu 
                325                 330                 335     


Leu Thr Gly Glu Ile Pro Tyr Lys Asp Val Asp Ser Ser Ala Ile Ile 
            340                 345                 350         


Trp Gly Val Gly Ser Asn Ser Leu His Leu Pro Val Pro Ser Ser Cys 
        355                 360                 365             


Pro Asp Gly Phe Lys Ile Leu Leu Arg Gln Cys Trp Asn Ser Lys Pro 
    370                 375                 380                 


Arg Asn Arg Pro Ser Phe Arg Gln Ile Leu Leu His Leu Asp Ile Ala 
385                 390                 395                 400 


Ser Ala Asp Val Leu Ser Thr Pro Gln Glu Thr Tyr Phe Lys Ser Gln 
                405                 410                 415     


Ala Glu Trp Arg Glu Glu Val Lys Leu His Phe Glu Lys Ile Lys Ser 
            420                 425                 430         


Glu Gly Thr Cys Leu His Arg Leu Glu Glu Glu Leu Val Met Arg Arg 
        435                 440                 445             


Arg Glu Glu Leu Arg His Ala Leu Asp Ile Arg Glu His Tyr Glu Arg 
    450                 455                 460                 


Lys Leu Glu Arg Ala Asn Asn Leu Tyr Met Glu Leu Asn Ala Leu Met 
465                 470                 475                 480 


Leu Gln Leu Glu Leu Lys Glu Arg Glu Leu Leu Arg Arg Glu Gln Ala 
                485                 490                 495     


Leu Glu Arg Arg Cys Pro Gly Leu Leu Lys Pro His Pro Ser Arg Gly 
            500                 505                 510         


Leu Leu His Gly Asn Thr Met Glu Lys Leu Ile Lys Lys Arg Asn Val 
        515                 520                 525             


Pro Gln Lys Leu Ser Pro His Ser Lys Arg Pro Asp Ile Leu Lys Thr 
    530                 535                 540                 


Glu Ser Leu Leu Pro Lys Leu Asp Ala Ala Leu Ser Gly Val Gly Leu 
545                 550                 555                 560 


Pro Gly Cys Pro Lys Gly Pro Pro Ser Pro Gly Arg Ser Arg Arg Gly 
                565                 570                 575     


Lys Thr Arg His Arg Lys Ala Ser Ala Lys Gly Ser Cys Gly Asp Leu 
            580                 585                 590         


Pro Gly Leu Arg Thr Ala Val Pro Pro His Glu Pro Gly Gly Pro Gly 
        595                 600                 605             


Ser Pro Gly Gly Leu Gly Gly Gly Pro Ser Ala Trp Glu Ala Cys Pro 
    610                 615                 620                 


Pro Ala Leu Arg Gly Leu His His Asp Leu Leu Leu Arg Lys Met Ser 
625                 630                 635                 640 


Ser Ser Ser Pro Asp Leu Leu Ser Ala Ala Leu Gly Ser Arg Gly Arg 
                645                 650                 655     


Gly Ala Thr Gly Gly Ala Gly Asp Pro Gly Ser Pro Pro Pro Ala Arg 
            660                 665                 670         


Gly Asp Thr Pro Pro Ser Glu Gly Ser Ala Pro Gly Ser Thr Ser Pro 
        675                 680                 685             


Asp Ser Pro Gly Gly Ala Lys Gly Glu Pro Pro Pro Pro Val Gly Pro 
    690                 695                 700                 


Gly Glu Gly Val Gly Leu Leu Gly Thr Gly Arg Glu Gly Thr Ser Gly 
705                 710                 715                 720 


Arg Gly Gly Ser Arg Ala Gly Ser Gln His Leu Thr Pro Ala Ala Leu 
                725                 730                 735     


Leu Tyr Arg Ala Ala Val Thr Arg Ser Gln Lys Arg Gly Ile Ser Ser 
            740                 745                 750         


Glu Glu Glu Glu Gly Glu Val Asp Ser Glu Val Glu Leu Thr Ser Ser 
        755                 760                 765             


Gln Arg Trp Pro Gln Ser Leu Asn Met Arg Gln Ser Leu Ser Thr Phe 
    770                 775                 780                 


Ser Ser Glu Asn Pro Ser Asp Gly Glu Glu Gly Thr Ala Ser Glu Pro 
785                 790                 795                 800 


Ser Pro Ser Gly Thr Pro Glu Val Gly Ser Thr Asn Thr Asp Glu Arg 
                805                 810                 815     


Pro Asp Glu Arg Ser Asp Asp Met Cys Ser Gln Gly Ser Glu Ile Pro 
            820                 825                 830         


Leu Asp Pro Pro Pro Ser Glu Val Ile Pro Gly Pro Glu Pro Ser Ser 
        835                 840                 845             


Leu Pro Ile Pro His Gln Glu Leu Leu Arg Glu Arg Gly Pro Pro Asn 
    850                 855                 860                 


Ser Glu Asp Ser Asp Cys Asp Ser Thr Glu Leu Asp Asn Ser Asn Ser 
865                 870                 875                 880 


Val Asp Ala Leu Arg Pro Pro Ala Ser Leu Pro Pro 
                885                 890         


<210>  2
<211>  242
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic Polypeptide

<400>  2

Ile Leu Asp Leu Gln Trp Val Gly Ser Gly Ala Gln Gly Ala Val Phe 
1               5                   10                  15      


Leu Gly Arg Phe His Gly Glu Glu Val Ala Val Lys Lys Val Arg Asp 
            20                  25                  30          


Leu Lys Glu Thr Asp Ile Lys His Leu Arg Lys Leu Lys His Pro Asn 
        35                  40                  45              


Ile Ile Thr Phe Lys Gly Val Cys Thr Gln Ala Pro Cys Tyr Cys Ile 
    50                  55                  60                  


Leu Met Glu Phe Cys Ala Gln Gly Gln Leu Tyr Glu Val Leu Arg Ala 
65                  70                  75                  80  


Gly Arg Pro Val Thr Pro Ser Leu Leu Val Asp Trp Ser Met Gly Ile 
                85                  90                  95      


Ala Gly Gly Met Asn Tyr Leu His Leu His Lys Ile Ile His Arg Asp 
            100                 105                 110         


Leu Lys Ser Pro Asn Met Leu Ile Thr Tyr Asp Asp Val Val Lys Ile 
        115                 120                 125             


Ser Asp Phe Gly Thr Ser Lys Glu Leu Ser Asp Lys Ser Thr Lys Met 
    130                 135                 140                 


Ser Phe Ala Gly Thr Val Ala Trp Met Ala Pro Glu Val Ile Arg Asn 
145                 150                 155                 160 


Glu Pro Val Ser Glu Lys Val Asp Ile Trp Ser Phe Gly Val Val Leu 
                165                 170                 175     


Trp Glu Leu Leu Thr Gly Glu Ile Pro Tyr Lys Asp Val Asp Ser Ser 
            180                 185                 190         


Ala Ile Ile Trp Gly Val Gly Ser Asn Ser Leu His Leu Pro Val Pro 
        195                 200                 205             


Ser Ser Cys Pro Asp Gly Phe Lys Ile Leu Leu Arg Gln Cys Trp Asn 
    210                 215                 220                 


Ser Lys Pro Arg Asn Arg Pro Ser Phe Arg Gln Ile Leu Leu His Leu 
225                 230                 235                 240 


Asp Ile 
        


<210>  3
<211>  116
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic Polypeptide

<400>  3

Leu Ser Thr Pro Gln Glu Thr Tyr Phe Lys Ser Gln Ala Glu Trp Arg 
1               5                   10                  15      


Glu Glu Val Lys Leu His Phe Glu Lys Ile Lys Ser Glu Gly Thr Cys 
            20                  25                  30          


Leu His Arg Leu Glu Glu Glu Leu Val Met Arg Arg Arg Glu Glu Leu 
        35                  40                  45              


Arg His Ala Leu Asp Ile Arg Glu His Tyr Glu Arg Lys Leu Glu Arg 
    50                  55                  60                  


Ala Asn Asn Leu Tyr Met Glu Leu Asn Ala Leu Met Leu Gln Leu Glu 
65                  70                  75                  80  


Leu Lys Glu Arg Glu Leu Leu Arg Arg Glu Gln Ala Leu Glu Arg Arg 
                85                  90                  95      


Cys Pro Gly Leu Leu Lys Pro His Pro Ser Arg Gly Leu Leu His Gly 
            100                 105                 110         


Asn Thr Met Glu 
        115     


<210>  4
<211>  22
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic Polypeptide

<400>  4

Val Lys Leu His Phe Glu Lys Ile Lys Ser Glu Gly Thr Cys Leu His 
1               5                   10                  15      


Arg Leu Glu Glu Glu Leu 
            20          


<210>  5
<211>  22
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic Polypeptide

<400>  5

Leu Asn Ala Leu Met Leu Gln Leu Glu Leu Lys Glu Arg Glu Leu Leu 
1               5                   10                  15      


Arg Arg Glu Gln Ala Leu 
            20          


<210>  6
<211>  520
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic Polypeptide

<400>  6

Met Ala Cys Leu His Glu Thr Arg Thr Pro Ser Pro Ser Phe Gly Gly 
1               5                   10                  15      


Phe Val Ser Thr Leu Ser Glu Ala Ser Met Arg Lys Leu Asp Pro Asp 
            20                  25                  30          


Thr Ser Asp Cys Thr Pro Glu Lys Asp Leu Thr Pro Thr Gln Cys Val 
        35                  40                  45              


Leu Arg Asp Val Val Pro Leu Gly Gly Gln Gly Gly Gly Gly Pro Ser 
    50                  55                  60                  


Pro Ser Pro Gly Gly Glu Pro Pro Pro Glu Pro Phe Ala Asn Ser Val 
65                  70                  75                  80  


Leu Gln Leu His Glu Gln Asp Ala Gly Gly Pro Gly Gly Ala Ala Gly 
                85                  90                  95      


Ser Pro Glu Ser Arg Ala Ser Arg Val Arg Ala Asp Glu Val Arg Leu 
            100                 105                 110         


Gln Cys Gln Ser Gly Ser Gly Phe Leu Glu Gly Leu Phe Gly Cys Leu 
        115                 120                 125             


Arg Pro Val Trp Thr Met Ile Gly Lys Ala Tyr Ser Thr Glu His Lys 
    130                 135                 140                 


Gln Gln Gln Glu Asp Leu Trp Glu Val Pro Phe Glu Glu Ile Leu Asp 
145                 150                 155                 160 


Leu Gln Trp Val Gly Ser Gly Ala Gln Gly Ala Val Phe Leu Gly Arg 
                165                 170                 175     


Phe His Gly Glu Glu Val Ala Val Lys Lys Val Arg Asp Leu Lys Glu 
            180                 185                 190         


Thr Asp Ile Lys His Leu Arg Lys Leu Lys His Pro Asn Ile Ile Thr 
        195                 200                 205             


Phe Lys Gly Val Cys Thr Gln Ala Pro Cys Tyr Cys Ile Leu Met Glu 
    210                 215                 220                 


Phe Cys Ala Gln Gly Gln Leu Tyr Glu Val Leu Arg Ala Gly Arg Pro 
225                 230                 235                 240 


Val Thr Pro Ser Leu Leu Val Asp Trp Ser Met Gly Ile Ala Gly Gly 
                245                 250                 255     


Met Asn Tyr Leu His Leu His Lys Ile Ile His Arg Asp Leu Lys Ser 
            260                 265                 270         


Pro Asn Met Leu Ile Thr Tyr Asp Asp Val Val Lys Ile Ser Asp Phe 
        275                 280                 285             


Gly Thr Ser Lys Glu Leu Ser Asp Lys Ser Thr Lys Met Ala Phe Ala 
    290                 295                 300                 


Gly Thr Val Ala Trp Met Ala Pro Glu Val Ile Arg Asn Glu Pro Val 
305                 310                 315                 320 


Ser Glu Lys Val Asp Ile Trp Ser Phe Gly Val Val Leu Trp Glu Leu 
                325                 330                 335     


Leu Thr Gly Glu Ile Pro Tyr Lys Asp Val Asp Ser Ser Ala Ile Ile 
            340                 345                 350         


Trp Gly Val Gly Ser Asn Ser Leu His Leu Pro Val Pro Ser Ser Cys 
        355                 360                 365             


Pro Asp Gly Phe Lys Ile Leu Leu Arg Gln Cys Trp Asn Ser Lys Pro 
    370                 375                 380                 


Arg Asn Arg Pro Ser Phe Arg Gln Ile Leu Leu His Leu Asp Ile Ala 
385                 390                 395                 400 


Ser Ala Asp Val Leu Ser Thr Pro Gln Glu Thr Tyr Phe Lys Ser Gln 
                405                 410                 415     


Ala Glu Trp Arg Glu Glu Val Lys Leu His Phe Glu Lys Ile Lys Ser 
            420                 425                 430         


Glu Gly Thr Cys Leu His Arg Leu Glu Glu Glu Leu Val Met Arg Arg 
        435                 440                 445             


Arg Glu Glu Leu Arg His Ala Leu Asp Ile Arg Glu His Tyr Glu Arg 
    450                 455                 460                 


Lys Leu Glu Arg Ala Asn Asn Leu Tyr Met Glu Leu Asn Ala Leu Met 
465                 470                 475                 480 


Leu Gln Leu Glu Leu Lys Glu Arg Glu Leu Leu Arg Arg Glu Gln Ala 
                485                 490                 495     


Leu Glu Arg Arg Cys Pro Gly Leu Leu Lys Pro His Pro Ser Arg Gly 
            500                 505                 510         


Leu Leu His Gly Asn Thr Met Glu 
        515                 520 


<210>  7
<211>  520
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic Polypeptide

<400>  7

Met Ala Cys Leu His Glu Thr Arg Thr Pro Ser Pro Ser Phe Gly Gly 
1               5                   10                  15      


Phe Val Ser Thr Leu Ser Glu Ala Ser Met Arg Lys Leu Asp Pro Asp 
            20                  25                  30          


Thr Ser Asp Cys Thr Pro Glu Lys Asp Leu Glu Pro Thr Gln Cys Val 
        35                  40                  45              


Leu Arg Asp Val Val Pro Leu Gly Gly Gln Gly Gly Gly Gly Pro Ser 
    50                  55                  60                  


Pro Ser Pro Gly Gly Glu Pro Pro Pro Glu Pro Phe Ala Asn Ser Val 
65                  70                  75                  80  


Leu Gln Leu His Glu Gln Asp Ala Gly Gly Pro Gly Gly Ala Ala Gly 
                85                  90                  95      


Ser Pro Glu Ser Arg Ala Ser Arg Val Arg Ala Asp Glu Val Arg Leu 
            100                 105                 110         


Gln Cys Gln Ser Gly Ser Gly Phe Leu Glu Gly Leu Phe Gly Cys Leu 
        115                 120                 125             


Arg Pro Val Trp Thr Met Ile Gly Lys Ala Tyr Ser Thr Glu His Lys 
    130                 135                 140                 


Gln Gln Gln Glu Asp Leu Trp Glu Val Pro Phe Glu Glu Ile Leu Asp 
145                 150                 155                 160 


Leu Gln Trp Val Gly Ser Gly Ala Gln Gly Ala Val Phe Leu Gly Arg 
                165                 170                 175     


Phe His Gly Glu Glu Val Ala Val Lys Lys Val Arg Asp Leu Lys Glu 
            180                 185                 190         


Thr Asp Ile Lys His Leu Arg Lys Leu Lys His Pro Asn Ile Ile Thr 
        195                 200                 205             


Phe Lys Gly Val Cys Thr Gln Ala Pro Cys Tyr Cys Ile Leu Met Glu 
    210                 215                 220                 


Phe Cys Ala Gln Gly Gln Leu Tyr Glu Val Leu Arg Ala Gly Arg Pro 
225                 230                 235                 240 


Val Thr Pro Ser Leu Leu Val Asp Trp Ser Met Gly Ile Ala Gly Gly 
                245                 250                 255     


Met Asn Tyr Leu His Leu His Lys Ile Ile His Arg Asp Leu Lys Ser 
            260                 265                 270         


Pro Asn Met Leu Ile Thr Tyr Asp Asp Val Val Lys Ile Ser Asp Phe 
        275                 280                 285             


Gly Thr Ser Lys Glu Leu Ser Asp Lys Ser Thr Lys Met Ala Phe Ala 
    290                 295                 300                 


Gly Thr Val Ala Trp Met Ala Pro Glu Val Ile Arg Asn Glu Pro Val 
305                 310                 315                 320 


Ser Glu Lys Val Asp Ile Trp Ser Phe Gly Val Val Leu Trp Glu Leu 
                325                 330                 335     


Leu Thr Gly Glu Ile Pro Tyr Lys Asp Val Asp Ser Ser Ala Ile Ile 
            340                 345                 350         


Trp Gly Val Gly Ser Asn Ser Leu His Leu Pro Val Pro Ser Ser Cys 
        355                 360                 365             


Pro Asp Gly Phe Lys Ile Leu Leu Arg Gln Cys Trp Asn Ser Lys Pro 
    370                 375                 380                 


Arg Asn Arg Pro Ser Phe Arg Gln Ile Leu Leu His Leu Asp Ile Ala 
385                 390                 395                 400 


Ser Ala Asp Val Leu Ser Thr Pro Gln Glu Thr Tyr Phe Lys Ser Gln 
                405                 410                 415     


Ala Glu Trp Arg Glu Glu Val Lys Leu His Phe Glu Lys Ile Lys Ser 
            420                 425                 430         


Glu Gly Thr Cys Leu His Arg Leu Glu Glu Glu Leu Val Met Arg Arg 
        435                 440                 445             


Arg Glu Glu Leu Arg His Ala Leu Asp Ile Arg Glu His Tyr Glu Arg 
    450                 455                 460                 


Lys Leu Glu Arg Ala Asn Asn Leu Tyr Met Glu Leu Asn Ala Leu Met 
465                 470                 475                 480 


Leu Gln Leu Glu Leu Lys Glu Arg Glu Leu Leu Arg Arg Glu Gln Ala 
                485                 490                 495     


Leu Glu Arg Arg Cys Pro Gly Leu Leu Lys Pro His Pro Ser Arg Gly 
            500                 505                 510         


Leu Leu His Gly Asn Thr Met Glu 
        515                 520 


<210>  8
<211>  116
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic Polypeptide

<400>  8

Leu Ala Thr Pro Gln Glu Thr Tyr Phe Lys Ser Gln Ala Glu Trp Arg 
1               5                   10                  15      


Glu Glu Val Lys Lys His Phe Glu Lys Ile Lys Ser Glu Gly Thr Cys 
            20                  25                  30          


Ile His Arg Leu Asp Glu Glu Leu Ile Arg Arg Arg Arg Glu Glu Leu 
        35                  40                  45              


Arg His Ala Leu Asp Ile Arg Glu His Tyr Glu Arg Lys Leu Glu Arg 
    50                  55                  60                  


Ala Asn Asn Leu Tyr Met Glu Leu Ser Ala Ile Met Leu Gln Leu Glu 
65                  70                  75                  80  


Met Arg Glu Lys Glu Leu Ile Lys Arg Glu Gln Ala Val Glu Lys Lys 
                85                  90                  95      


Tyr Pro Gly Thr Tyr Lys Arg His Pro Val Arg Pro Ile Ile His Pro 
            100                 105                 110         


Asn Ala Met Glu 
        115     


<210>  9
<211>  2680
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Synthetic Polynucleotide

<400>  9
atggcttgcc tccatgagac ccgaacaccc tctccttcct ttgggggctt tgtgtctacc       60

ctaagtgagg catccatgcg caagctggac ccagacactt ctgactgcac tcccgagaag      120

gacctgacgc ctacccagtg tgtacttcga gatgtggtac cccttggtgg gcagggtggg      180

ggagggccca gcccctcccc aggtggagag ccgccccctg agccttttgc caacagtgtc      240

ctgcagctac atgagcagga tgcagggggc ccagggggag cagctgggtc acctgagagt      300

cgggcatcca gagttcgagc tgacgaggtg cgactgcagt gccagagtgg cagtggcttc      360

cttgagggcc tctttggctg cctgcgccct gtctggacca tgattggcaa agcctactcc      420

actgagcaca agcagcagca ggaagacctt tgggaggtcc cctttgagga aatcctggac      480

ctgcagtggg tgggctcagg ggcccagggt gctgtcttcc tggggcgctt ccacggggag      540

gaggtggctg tgaagaaggt gcgagacctc aaagaawacc gacatcaagc acttgcgaaa      600

gctgaagcac cccaacatca tcactttcaa gggtgtgtgc acccaggctc cctgctactg      660

catcctcatg gagttctgcg cccagggcca gctgtatgag gtactgcggg ctggccgccc      720

tgtcaccccc tccttactgg ttgactggtc catgggcatc gctggtggca tgaactacct      780

gcacctgcac aagattatcc acagggatct caagtcaccc aacatgctaa tcacctacga      840

cgatgtggtg aagatctcag attttggcac ttccaaggag ctgagtgaca agagcaccaa      900

gatgtccttt gcagggacag tagcctggat ggcccctgag gtgatccgca atgaacctgt      960

gtctgagaag gtcgacatct ggtcctttgg cgtggtgcta tgggaactgc tgactggtga     1020

gatcccctac aaagacgtag attcctcagc cattatctgg ggtgtgggaa gcaacagtct     1080

ccatctgccc gtgccctcca gttgcccaga tggtttcaag atcctgcttc gccagtgctg     1140

gaatagcaaa ccacgaaatc gcccatcatt ccgacagatc ctgctgcatc tggacattgc     1200

ctcagctgat gtactctcca caccccagga gacttacttt aagtcccagg cagagtggcg     1260

ggaagaagta aaactgcact ttgaaaagat taagtcagaa gggacctgtc tgcaccgcct     1320

agaagaggaa ctggtgatga ggaggaggga ggagctcaga cacgccctgg acatcaggga     1380

gcactatgaa aggaagctgg agagagccaa caacctgtat atggaactta atgccctcat     1440

gttgcagctg gaactcaagg agagggagct gctcaggcga gagcaagctt tagagcggag     1500

gtgcccaggc ctgctgaagc cacacccttc ccggggcctc ctgcatggaa acacaatgga     1560

gaagcttatc aagaagagga atgtgccaca gaagctgtca ccccatagca aaaggccaga     1620

tatcctcaag acggagtctt tgctccctaa actagatgca gccctgagtg gggtggggct     1680

tcctgggtgt cctaagggcc ccccctcacc aggacggagt cgccgtggca agacccgtca     1740

ccgcaaggcc agcgccaagg ggagctgtgg ggacctgcct gggcttcgta cagctgtgcc     1800

accccatgaa cctggaggac caggaagccc agggggccta ggagggggac cctcagcctg     1860

ggaggcctgc cctcccgccc tccgtgggct tcatcatgac ctcctgctcc gcaaaatgtc     1920

ttcatcgtcc ccagacctgc tgtcagcagc actagggtcc cggggccggg gggccacagg     1980

cggagctggg gatcctggct caccacctcc ggcccggggt gacaccccac caagtgaggg     2040

ctcagcccct ggctccacca gcccagattc acctggggga gccaaagggg aaccacctcc     2100

tccagtaggg cctggtgaag gtgtggggct tctgggaact ggaagggaag ggacctcagg     2160

ccggggagga agccgggctg ggtcccagca cttgacccca gctgcactgc tgtacagggc     2220

tgccgtcacc cgaagtcaga aacgtggcat ctcatcggaa gaggaggaag gagaggtaga     2280

cagtgaagta gagctgacat caagccagag gtggcctcag agcctgaaca tgcgccagtc     2340

actatctacc ttcagctcag agaatccatc agatggggag gaaggcacag ctagtgaacc     2400

ttcccccagt ggcacacctg aagttggcag caccaacact gatgagcggc cagatgagcg     2460

gtctgatgac atgtgctccc agggctcaga aatcccactg gacccacctc cttcagaggt     2520

catccctggc cctgaaccca gctccctgcc cattccacac caggaacttc tcagagagcg     2580

gggccctccc aattctgagg actcagactg tgacagcact gaattggaca actccaacag     2640

cgttgatgcc ttgcggcccc cagcttccct ccctccatga                           2680


<210>  10
<211>  1563
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Synthetic Polynucleotide

<400>  10
atggcttgcc tccatgagac ccgaacaccc tctccttcct ttgggggctt tgtgtctacc       60

ctaagtgagg catccatgcg caagctggac ccagacactt ctgactgcac tcccgagaag      120

gacctgacgc ctacccagtg tgtacttcga gatgtggtac cccttggtgg gcagggtggg      180

ggagggccca gcccctcccc aggtggagag ccgccccctg agccttttgc caacagtgtc      240

ctgcagctac atgagcagga tgcagggggc ccagggggag cagctgggtc acctgagagt      300

cgggcatcca gagttcgagc tgacgaggtg cgactgcagt gccagagtgg cagtggcttc      360

cttgagggcc tctttggctg cctgcgccct gtctggacca tgattggcaa agcctactcc      420

actgagcaca agcagcagca ggaagacctt tgggaggtcc cctttgagga aatcctggac      480

ctgcagtggg tgggctcagg ggcccagggt gctgtcttcc tggggcgctt ccacggggag      540

gaggtggctg tgaagaaggt gcgagacctc aaagaaaccg acatcaagca cttgcgaaag      600

ctgaagcacc ccaacatcat cactttcaag ggtgtgtgca cccaggctcc ctgctactgc      660

atcctcatgg agttctgcgc ccagggccag ctgtatgagg tactgcgggc tggccgccct      720

gtcaccccct ccttactggt tgactggtcc atgggcatcg ctggtggcat gaactacctg      780

cacctgcaca agattatcca cagggatctc aagtcaccca acatgctaat cacctacgac      840

gatgtggtga agatctcaga ttttggcact tccaaggagc tgagtgacaa gagcaccaag      900

atggcctttg cagggacagt agcctggatg gcccctgagg tgatccgcaa tgaacctgtg      960

tctgagaagg tcgacatctg gtcctttggc gtggtgctat gggaactgct gactggtgag     1020

atcccctaca aagacgtaga ttcctcagcc attatctggg gtgtgggaag caacagtctc     1080

catctgcccg tgccctccag ttgcccagat ggtttcaaga tcctgcttcg ccagtgctgg     1140

aatagcaaac cacgaaatcg cccatcattc cgacagatcc tgctgcatct ggacattgcc     1200

tcagctgatg tactctccac accccaggag acttacttta agtcccaggc agagtggcgg     1260

gaagaagtaa aactgcactt tgaaaagatt aagtcagaag ggacctgtct gcaccgccta     1320

gaagaggaac tggtgatgag gaggagggag gagctcagac acgccctgga catcagggag     1380

cactatgaaa ggaagctgga gagagccaac aacctgtata tggaacttaa tgccctcatg     1440

ttgcagctgg aactcaagga gagggagctg ctcaggcgag agcaagcttt agagcggagg     1500

tgcccaggcc tgctgaagcc acacccttcc cggggcctcc tgcatggaaa cacaatggag     1560

tag                                                                   1563


<210>  11
<211>  1563
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Synthetic Polynucleotide

<400>  11
atggcttgcc tccatgagac ccgaacaccc tctccttcct ttgggggctt tgtgtctacc       60

ctaagtgagg catccatgcg caagctggac ccagacactt ctgactgcac tcccgagaag      120

gacctggagc ctacccagtg tgtacttcga gatgtggtac cccttggtgg gcagggtggg      180

ggagggccca gcccctcccc aggtggagag ccgccccctg agccttttgc caacagtgtc      240

ctgcagctac atgagcagga tgcagggggc ccagggggag cagctgggtc acctgagagt      300

cgggcatcca gagttcgagc tgacgaggtg cgactgcagt gccagagtgg cagtggcttc      360

cttgagggcc tctttggctg cctgcgccct gtctggacca tgattggcaa agcctactcc      420

actgagcaca agcagcagca ggaagacctt tgggaggtcc cctttgagga aatcctggac      480

ctgcagtggg tgggctcagg ggcccagggt gctgtcttcc tggggcgctt ccacggggag      540

gaggtggctg tgaagaaggt gcgagacctc aaagaaaccg acatcaagca cttgcgaaag      600

ctgaagcacc ccaacatcat cactttcaag ggtgtgtgca cccaggctcc ctgctactgc      660

atcctcatgg agttctgcgc ccagggccag ctgtatgagg tactgcgggc tggccgccct      720

gtcaccccct ccttactggt tgactggtcc atgggcatcg ctggtggcat gaactacctg      780

cacctgcaca agattatcca cagggatctc aagtcaccca acatgctaat cacctacgac      840

gatgtggtga agatctcaga ttttggcact tccaaggagc tgagtgacaa gagcaccaag      900

atggcctttg cagggacagt agcctggatg gcccctgagg tgatccgcaa tgaacctgtg      960

tctgagaagg tcgacatctg gtcctttggc gtggtgctat gggaactgct gactggtgag     1020

atcccctaca aagacgtaga ttcctcagcc attatctggg gtgtgggaag caacagtctc     1080

catctgcccg tgccctccag ttgcccagat ggtttcaaga tcctgcttcg ccagtgctgg     1140

aatagcaaac cacgaaatcg cccatcattc cgacagatcc tgctgcatct ggacattgcc     1200

tcagctgatg tactctccac accccaggag acttacttta agtcccaggc agagtggcgg     1260

gaagaagtaa aactgcactt tgaaaagatt aagtcagaag ggacctgtct gcaccgccta     1320

gaagaggaac tggtgatgag gaggagggag gagctcagac acgccctgga catcagggag     1380

cactatgaaa ggaagctgga gagagccaac aacctgtata tggaacttaa tgccctcatg     1440

ttgcagctgg aactcaagga gagggagctg ctcaggcgag agcaagcttt agagcggagg     1500

tgcccaggcc tgctgaagcc acacccttcc cggggcctcc tgcatggaaa cacaatggag     1560

tag                                                                   1563


<210>  12
<211>  354
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Synthetic Polynucleotide

<400>  12
atgcttgcca ccccacaaga aacttacttc aagtctcagg ctgaatggag agaagaagtg       60

aaaaaacatt ttgagaagat caaaagtgaa ggaacttgta tacaccggtt agatgaagaa      120

ctgattcgaa ggcgcagaga agagctcagg catgcgctgg atattcgtga acactatgag      180

cggaagcttg agcgggcgaa taatttatac atggaattga gtgccatcat gctgcagcta      240

gaaatgcggg agaaggagct cattaagcgt gagcaagcag tggaaaagaa gtatcctggg      300

acctacaaac gacaccctgt tcgtcctatc atccatccca atgccatgga gtga            354


<210>  13
<211>  859
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic Polypeptide

<400>  13

Met Ala Cys Leu His Glu Thr Arg Thr Pro Ser Pro Ser Phe Gly Gly 
1               5                   10                  15      


Phe Val Ser Thr Leu Ser Glu Ala Ser Met Arg Lys Leu Asp Pro Asp 
            20                  25                  30          


Thr Ser Asp Cys Thr Pro Glu Lys Asp Leu Thr Pro Thr His Val Leu 
        35                  40                  45              


Gln Leu His Glu Gln Asp Ala Gly Gly Pro Gly Gly Ala Ala Gly Ser 
    50                  55                  60                  


Pro Glu Ser Arg Ala Ser Arg Val Arg Ala Asp Glu Val Arg Leu Gln 
65                  70                  75                  80  


Cys Gln Ser Gly Ser Gly Phe Leu Glu Gly Leu Phe Gly Cys Leu Arg 
                85                  90                  95      


Pro Val Trp Thr Met Ile Gly Lys Ala Tyr Ser Thr Glu His Lys Gln 
            100                 105                 110         


Gln Gln Glu Asp Leu Trp Glu Val Pro Phe Glu Glu Ile Leu Asp Leu 
        115                 120                 125             


Gln Trp Val Gly Ser Gly Ala Gln Gly Ala Val Phe Leu Gly Arg Phe 
    130                 135                 140                 


His Gly Glu Glu Val Ala Val Lys Lys Val Arg Asp Leu Lys Glu Thr 
145                 150                 155                 160 


Asp Ile Lys His Leu Arg Lys Leu Lys His Pro Asn Ile Ile Thr Phe 
                165                 170                 175     


Lys Gly Val Cys Thr Gln Ala Pro Cys Tyr Cys Ile Leu Met Glu Phe 
            180                 185                 190         


Cys Ala Gln Gly Gln Leu Tyr Glu Val Leu Arg Ala Gly Arg Pro Val 
        195                 200                 205             


Thr Pro Ser Leu Leu Val Asp Trp Ser Met Gly Ile Ala Gly Gly Met 
    210                 215                 220                 


Asn Tyr Leu His Leu His Lys Ile Ile His Arg Asp Leu Lys Ser Pro 
225                 230                 235                 240 


Asn Met Leu Ile Thr Tyr Asp Asp Val Val Lys Ile Ser Asp Phe Gly 
                245                 250                 255     


Thr Ser Lys Glu Leu Ser Asp Lys Ser Thr Lys Met Ser Phe Ala Gly 
            260                 265                 270         


Thr Val Ala Trp Met Ala Pro Glu Val Ile Arg Asn Glu Pro Val Ser 
        275                 280                 285             


Glu Lys Val Asp Ile Trp Ser Phe Gly Val Val Leu Trp Glu Leu Leu 
    290                 295                 300                 


Thr Gly Glu Ile Pro Tyr Lys Asp Val Asp Ser Ser Ala Ile Ile Trp 
305                 310                 315                 320 


Gly Val Gly Ser Asn Ser Leu His Leu Pro Val Pro Ser Ser Cys Pro 
                325                 330                 335     


Asp Gly Phe Lys Ile Leu Leu Arg Gln Cys Trp Asn Ser Lys Pro Arg 
            340                 345                 350         


Asn Arg Pro Ser Phe Arg Gln Ile Leu Leu His Leu Asp Ile Ala Ser 
        355                 360                 365             


Ala Asp Val Leu Ser Thr Pro Gln Glu Thr Tyr Phe Lys Ser Gln Ala 
    370                 375                 380                 


Glu Trp Arg Glu Glu Val Lys Leu His Phe Glu Lys Ile Lys Ser Glu 
385                 390                 395                 400 


Gly Thr Cys Leu His Arg Leu Glu Glu Glu Leu Val Met Arg Arg Arg 
                405                 410                 415     


Glu Glu Leu Arg His Ala Leu Asp Ile Arg Glu His Tyr Glu Arg Lys 
            420                 425                 430         


Leu Glu Arg Ala Asn Asn Leu Tyr Met Glu Leu Asn Ala Leu Met Leu 
        435                 440                 445             


Gln Leu Glu Leu Lys Glu Arg Glu Leu Leu Arg Arg Glu Gln Ala Leu 
    450                 455                 460                 


Glu Arg Arg Cys Pro Gly Leu Leu Lys Pro His Pro Ser Arg Gly Leu 
465                 470                 475                 480 


Leu His Gly Asn Thr Met Glu Lys Leu Ile Lys Lys Arg Asn Val Pro 
                485                 490                 495     


Gln Lys Leu Ser Pro His Ser Lys Arg Pro Asp Ile Leu Lys Thr Glu 
            500                 505                 510         


Ser Leu Leu Pro Lys Leu Asp Ala Ala Leu Ser Gly Val Gly Leu Pro 
        515                 520                 525             


Gly Cys Pro Lys Gly Pro Pro Ser Pro Gly Arg Ser Arg Arg Gly Lys 
    530                 535                 540                 


Thr Arg His Arg Lys Ala Ser Ala Lys Gly Ser Cys Gly Asp Leu Pro 
545                 550                 555                 560 


Gly Leu Arg Thr Ala Val Pro Pro His Glu Pro Gly Gly Pro Gly Ser 
                565                 570                 575     


Pro Gly Gly Leu Gly Gly Gly Pro Ser Ala Trp Glu Ala Cys Pro Pro 
            580                 585                 590         


Ala Leu Arg Gly Leu His His Asp Leu Leu Leu Arg Lys Met Ser Ser 
        595                 600                 605             


Ser Ser Pro Asp Leu Leu Ser Ala Ala Leu Gly Ser Arg Gly Arg Gly 
    610                 615                 620                 


Ala Thr Gly Gly Ala Gly Asp Pro Gly Ser Pro Pro Pro Ala Arg Gly 
625                 630                 635                 640 


Asp Thr Pro Pro Ser Glu Gly Ser Ala Pro Gly Ser Thr Ser Pro Asp 
                645                 650                 655     


Ser Pro Gly Gly Ala Lys Gly Glu Pro Pro Pro Pro Val Gly Pro Gly 
            660                 665                 670         


Glu Gly Val Gly Leu Leu Gly Thr Gly Arg Glu Gly Thr Ser Gly Arg 
        675                 680                 685             


Gly Gly Ser Arg Ala Gly Ser Gln His Leu Thr Pro Ala Ala Leu Leu 
    690                 695                 700                 


Tyr Arg Ala Ala Val Thr Arg Ser Gln Lys Arg Gly Ile Ser Ser Glu 
705                 710                 715                 720 


Glu Glu Glu Gly Glu Val Asp Ser Glu Val Glu Leu Thr Ser Ser Gln 
                725                 730                 735     


Arg Trp Pro Gln Ser Leu Asn Met Arg Gln Ser Leu Ser Thr Phe Ser 
            740                 745                 750         


Ser Glu Asn Pro Ser Asp Gly Glu Glu Gly Thr Ala Ser Glu Pro Ser 
        755                 760                 765             


Pro Ser Gly Thr Pro Glu Val Gly Ser Thr Asn Thr Asp Glu Arg Pro 
    770                 775                 780                 


Asp Glu Arg Ser Asp Asp Met Cys Ser Gln Gly Ser Glu Ile Pro Leu 
785                 790                 795                 800 


Asp Pro Pro Pro Ser Glu Val Ile Pro Gly Pro Glu Pro Ser Ser Leu 
                805                 810                 815     


Pro Ile Pro His Gln Glu Leu Leu Arg Glu Arg Gly Pro Pro Asn Ser 
            820                 825                 830         


Glu Asp Ser Asp Cys Asp Ser Thr Glu Leu Asp Asn Ser Asn Ser Val 
        835                 840                 845             


Asp Ala Leu Arg Pro Pro Ala Ser Leu Pro Pro 
    850                 855                 


<210>  14
<211>  591
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Synthetic Polynucleotide

<400>  14
atcaacctct ggattacaaa atttgtgaaa gattgactga tattcttaac tatgttgctc       60

cttttacgct gtgtggatat gctgctttaa tgcctctgta tcatgctatt gcttcccgta      120

cggctttcgt tttctcctcc ttgtataaat cctggttgct gtctctttat gaggagttgt      180

ggcccgttgt ccgtcaacgt ggcgtggtgt gctctgtgtt tgctgacgca acccccactg      240

gctggggcat tgccaccacc tgtcaactcc tttctgggac tttcgctttc cccctcccga      300

tcgccacggc agaactcatc gccgcctgcc ttgcccgctg ctggacaggg gctaggttgc      360

tgggcactga taattccgtg gtgttgtcgg ggaaatcatc gtcctttcct tggctgctcg      420

cctgtgttgc caactggatc ctgcgcggga cgtccttctg ctacgtccct tcggctctca      480

atccagcgga cctcccttcc cgaggccttc tgccggttct gcggcctctc ccgcgtcttc      540

gctttcggcc tccgacgagt cggatctccc tttgggccgc ctccccgcct g               591


